WO2000009525A2 - Low adenosine anti-sense oligonucleotide agent, composition, kit and treatments - Google Patents

Abstract

A composition comprises a nucleic acid comprising an oligo anti-sense to a target such as polypeptide(s) associated with an ailment afflicting lung airways, genes and mRNAs encoding them, genomic and mRNA flanking regions, intron and exon borders and all regulatory and functionally related segments of the genes and mRNAs encoding the polypeptides, their salts and mixtures. Various formulations contain a requisite carrier, and optionally other additives and biologically active agents. The agent of the invention may be prepared by selecting a target gene(s), genomic flanking region(s), RNA(s) and/or polypeptide(s) associated with a disease(s) or condition(s) afflicting lung airways, obtaining the sequence of the mRNA(s) corresponding to the target gene(s) and/or genomic flanking region(s), and/or RNAs encoding the target polypeptide(s), selecting at least one segment of the mRNA which may be up to 60 % free of thymidine (T) and synthesizing one or more anti-sense oligonucleotide(s) to the mRNA segments which are free of adenosine (A) by substituting a universal base for A when present in the oligonucleotide. The agent may be prepared by selection of target nucleic acid sequences with GC running stretches, which have low T content, and by optionally replacing A in the anti-sense oligonucleotides with a AUniversal base@. The agent, composition and formulations are used for prophylactic, preventive and therapeutic treatment of ailments associated with impaired respiration, allergy(ies) and/or inflammation, such as pulmonary vasoconstriction, inflammation, allergies, asthma, impeded respiration, lung pain, cystic fibrosis, bronchoconstriction, pulmonary hypertension and bronchoconstriction, chronic bronchitis, emphysema, chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome (ARDS), ischemic conditions including ischemia itself, and cancers such as leukemias, lymphomas, carcinomas, and the like, e.g. colon cancer, breast cancer, pancreatic cancer, lung cancer, hepatocellular carcinoma, kidney cancer, melanoma, hepatic metastasis, etc., as well as all types of cancers with may metastasize or have metastasized to the lung(s), including breast and prostate cancer. The present treatment is suitable for administration in combination with other treatments, e.g. before, during and after other treatments, including radiation, chemotherapy, antibody therapy and surgery, among others. The present agent is effectively administered preventatively, prophylactically or therapeutically by itself for conditions without known therapies, or as a substitute for, or in conjunction with, other therapies exhibiting undesirable side effects. The treatment of this invention may be administered directly into the respiratory system of a subject, so that the agent has direct access to the airways and the lungs.

Description

EPI-109

LOW ADENOSINE ANTI-SENSE OLIGONUCLEOTIDE AGENT, COMPOSITION, KIT & TREATMENTS

BACKGROUND OF THE INVENTION Field of the Invention

This application relates to an agent comprising anti-sense oligonucleotides of low or no adenosme content These agents are suitable for the treatment of diseases associated with ιnflamrfiatιon_> impaired airways^', including lung disease and diseases whose secondary effects afflict the lungs of a subject Examples of these diseases are allergies, asthma, impeded respiration, pain, cystic fibrosis, and cancers such as leukemias, e g colon cancer, and the like The present agent may be administered prophylactically or therapeutically in conjunction with other therapies or may be utilized as a substitute for therapies that have significant, negative side effects

Background of the Invention

Respiratory ailments, associated with a variety ot diseases and conditions, are extremely common in the general population, and more so in certain ethnic groups, such as African Americans In some cases they are accompanied by inflammation which aggravates the condition of the lungs Asthma, for example, is one ot the most common diseases in industrialized countries In the United States it accounts tor about 1 % of all health care costs An alarming increase in both the prevalence and mortaht\ of asthma over the past decade has been reported, and asthma is predicted to be the preeminent occupational lung disease m the next decade While the increasing mortality of asthma in industrialized countries could be attributable to the increased reliance upon beta agonists in the treatment of this disease, the underlying causes of asthma remain poorly understood

Anti-sense oligonucleotides have received considerable theoretical consideration as potential useful pharmacological agents in human disease Their practical application in actual models ot human disease, however, has been somewhat elusive One important impediment to their effective application has been a difficulty in findmg an appropriate route of admmistration to deliver them to their site of action Many in vivo experiments were conducted by administering anti-sense oligonucleotides directly to specific regions of the brain These applications, however, necessarily have limited clinical utility due to their invasive nature

The systemic administration of anti-sense oligonucleotides also presents significant problems, not the least being an inherent difficulty targeting disease-involved tissues In contrast, the lung is an excellent target tor the direct administration of anti-sense oligonucleotides and provides a non invasive and a tissue specific route The delivery ot anti-sense agents to the lung has been relatn elv undeveloped

Adenosme may constitute an important mediator in the lung tor various diseases, including bronchial asthma Its potential role was suggested by the finding that asthmatics respond favorably to aerosolized adenosme with marked bronchoconstriction whereas normal individuals do not An asthmatic rabbit animal model, the dust mite allergic rabbit model for human asthma, responded in a similar fashion to aerosolized adenosme with marked bronchoconstriction whereas non-asthmatic rabbits showed no response More recent work with this animal model suggested that adenosine-induced bronchoconstriction and bronchial hyperresponsiveness in asthma may be mediated primarily through the stimulation of adenosme receptors Adenosme has also been shown to cause adverse effects, including death, when administered therapeutically for other diseases and conditions in subjects with previously undiagnosed hyper reactive airways

A handful of medicaments have been available for the treatment of respiratory diseases and conditions, although in general they all have limitations Theophyllme, an important drug in the treatment of asthma, is a known adenosme receptor antagonist which was reported to eliminate adenosme-mediated bronchoconstriction in asthmatic rabbits A selective adenosme A_! receptor antagonist, 8-cycloρentyl-l , 3-dιpropylxanthιne (DPCPX) was also reported to inhibit adenosme-mediated bronchoconstriction and bronchial hyperresponsiveness in allergic rabbits The therapeutic and preventative applications of currently available adenosme A, receptor-specific antagonists are, nevertheless, limited by their toxicity Theophyllme, for example, has been widely used in the treatment ot asthma, but is associated with frequent, significant toxicity resulting from its narrow therapeutic dose range DPCPX is tar too toxic to be useful clinically The fact that despite decades ot extensive research, no specific adenosme receptor antagonist is available tor clinical use attests to the general toxicity of these agents

Anti-sense oligonucleotides have received considerable theoretical consideration for their potential use as pharmacological agents in human disease Finding practical and effective applications of these agents in actual models of human disease, however, have been few and far between, particularly because they had to be administered in large doses Another important consideration in the pharmacologic application of these molecules is their route of admmistration Many in vivo applications have mvolved the direct admmistration of anti-sense oligonucleotides to limited regions of the bram Such applications, however, have limited clinical utility due to their invasive nature

The systemic admmistration of anti-sense oligonucleotides as pharmacological agents has been found to have also significant problems, not the least ot which being a difficulty in targeting disease- involved tissues That is, the necessary dilution of the anti-sense oligonucleotide m the circulatory system makes extremely difficult to attain a therapeutic dose at the target tissue by intravenous or oral administration The bioavailabi ty of orally administered anti-sense oligonucleotides is very low, of the order of less than about 5%

There are presently no effective therapies for treating these ailments, or at least no therapies which are effective and devoid of significant detrimental side effects Accordingly, there is still a need for an agent for the treatment of ailments afflicting the lung airways, including respiratory problems and inflammation, which is highly effective and producing minimal, or entirely devoid of, side effects

SUMMARY OF THE INVENTION

This invention relates to an agent which comprises an oligonucleotide (oligo) consisting essentially of less than about 15 % adenosme (A), which is selected from the group consisting ot anti-sense oligonucleotides to mRNAs corresponding to target genes, to genomic flanking regions selected from the group consisting of intron and exon borders, such as the 5' end, the 3' end and the juxta-section between coding and non-coding regions, and to all segments of mRNAs encoding polypeptides associated with ailments afflicting lung airways, combinations thereof, pharmaceutically acceptable salts thereof, and mixtures thereof The mRNA(s), tor example, encode polypeptιde(s) such as transcription factors, stimulating and activating factors, interleukins, mterleukin receptors, chemokines, chemokme receptors, endogenously produced specific and non-specific enzymes, immunoglobulins, antibody receptors, central nervous system (CNS) and peripheral nervous and non- nervous system receptors, CNS and peripheral nervous and non-nervous system peptide transmitters, adhesion molecules, defensines, growth factors, vasoactive peptides and receptors, and binding proteins, or those mRNA which correspond to an oncogene The agents is are provided in the form of specific compositions and formulations, with a carrier, and optionally with other therapeutic agents and additives which are typically used for administration by a specific route, e g into the respiratory system The agent is also provided as a capsule or cartridge, and in the form of a kit

This agent is suitable tor the treatment of diseases and conditions associated with impaired respiration and inflammation, including lung diseases, ailments and conditions that have a negative effect on the lungs ot a subject Examples of diseases and conditions, which may be treated preventively, prophylactically and therapeutically with the agent ot this invention, are pulmonary vasoconstπction, inflammation, allergies, asthma, impeded respiration, respiratory distress syndrome, pain, cystic fibrosis, pulmonary hypertension, pulmonary vasoconstπction, emphysema, chronic obstructive pulmonary disease (COPD), and cancers such as leukemias, lymphomas, carcinomas, and the like, e g colon cancer, breast cancer, lung cancer, pancreatic cancer, hepatocellular carcinoma, kidney cancer, melanoma, hepatic metastases, etc , as well as all types of cancers which may metastasize or have metastasized to the lung(s), includmg breast and prostate cancer The present agent(s) is (are) also suitable for administration before, during and after other treatments, including radiation, chemotherapy, antibodv therapy, phototherapy and cancer, and other types of surgery Alternatively, the present agent may be effectively administered preventively, prophylactically or therapeutically, and in conjunction with other therapies, or by itself for conditions without known therapies or as a substitute for therapies that have significant negative side effects

The composition of this invention may be administered by transdermal or systemic routes, including by, but not exclusively, oral, mtracavitary, intranasal, intraanal, mtravagmal, transdermal, intradermal, mtrabuccal, intravenous, subcutaneous, intramuscular, intratumor, mtraglandular, by inhalation, intraarterial, lntravascular in general, into the ear, lntracramal, mtrathecal, mtraorgan including via a shunt to, for example, the liver or other organs by implantation and intraocular administration to a human or any other animal, including vertebrates such as mammals In a preferred embodiment, the present agents are administered directly into the respirator) system of a subject, so that the agent has direct access to the lungs, in an amount effective to reduce or inhibit the effect in the lung of the targeted diseases or conditions.

Also part of this mvention is a method of producing an anti-sense oligonucleotide consistmg essentially of less than about 15% adenosme (A), by selectmg a target includmg genes, genomic flankmg regions, RNAs and polypeptide associated with an ailment afflicting the lung airways, obtaming the sequence of a mRNA(s) corresponding to the target gene(s) and/or their genomic flankmg regιon(s) and/or the juxta-membrane regions thereof, and mRNA(s) encoding the target polypeptιde(s), selecting at least one segment of the mRNA(s), and synthesizing one or more anti-sense ohgonucleotιde(s) to the selected mRNA segment(s), and substituting, if necessary , a universal base(s) for one or more A to reduce the proportion of A present in the oligonucleotide to less than 15%.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

This invention arose from a desire by the inventor to improve on his own prior discovery that anti-sense oligonucleotides (oligos) may be utilized therapeutically in the treatment of diseases or conditions which impair respiration, cause inflammation, constrict bronchial tissue or the lung airways, or otherwise impede normal breathing The inventor reasoned that he could improve on his prior discovery that anti-sense oligos targeted to genes associated with such ailments could effectively treat and prevent the effects and symptomatology ot such dιsease(s) or condιtιon(s) The present invention is premised on the recent discovery by the inventor that oligonucleotides are metabolized in vivo to their deoxynucleotides In the case of adenosme (A)-contammg oligonucleotides, there is break down with release of deoxyadenosine which, in turn, activates adenosme receptors causing bronchoconstriction, inflammation and the like.

The present technology relies on the design of anti-sense oligos targeted to mRNAs associated with ailments involving lung airway pathology(ιes), and on their modification to reduce the occurrence of undesirable side effects caused by their release of adenosme upon breakdown, while preserving their activity and efficacy tor their intended purpose In this manner, the inventor targets a specific gene to design one or more anti-sense olιgonucleotιde(s) (oligos) that selectively bmd(s) to the corresponding mRNA, and then reduces, if necessary, their content of adenosme via substitution with universal base or an adenosme analog incapable of activating adenosme A, A_2bor A₃ receptors. Based on his prior experience in the field, the inventor reasoned that in addition to Adownregulatmg® specific genes, he could increase the effect of the agent(s) administered by either selecting segments of RNA that are devoid, or have a low content, of thymidine (T) or, alternatively, substitute one or more adenosme(s) present m the designed ohgonucleotιde(s) with other nucleotide bases, so called universal bases, which bind to thymidine but lack the ability to activate adenosme receptors and otherwise exercise the constricting effect of adenosme m the lungs, etc Given that adenosme (A) is a nucleotide base complementary to thymidine (T), when a T appears in the RNA, the anti-sense oligo will have an A at the same position For consistency's sake, all RNAs and oligonucleotides are represented in this patent by a single strand in the 5' to 3' direction, when read from left to right, although their complementary sequence(s) is (are) also encompassed within the tour corners of the invention. In addition, all nucleotide bases and amino acids are represented utilizing the recommendations of the IUPAC-IUB Biochemical Nomenclature Commission, or by the known 3-letter code (for amino acids).

The method of the present invention may be used to treat ailments associated with reduced airway function m a subject, whatever its cause. The adenosme content of the anti-sense agent(s) of the invention have a reduced A content to prevent its liberation upon in vivo degradation of the agent(s) Examples of airway diseases that may be treated by the method of the present invention mclude cystic fibrosis, asthma, pulmonary hypertension and vasoconstπction, chronic obstructive pulmonary disease (COPD), chronic bronchitis, respiratory distress syndrome, lung cancer and lung metastatic cancers and other airway diseases, including those with inflammatory response

Anti-sense oligos to the adenosme A,, A_2a, A_2b, and A₃ receptors, CCR3 (chemokme receptors), bradykimn 2B, CAM (vascular cell adhesion molecule), and eosinophil receptors, among others, have been shown to be effective in down-regulating the expression of their genes Some of these act to alleviate the symptoms or reduce respiratory ailments and/or inflammation, for example, by Adown regulation® ot the adenosme A,, A_2a, A_2b, and/or A₃ receptors and CCR3, bradykimn 2B, VCAM (vascular cell adhesion molecule) and eosinophil receptors These agents are preferably administered directly into the respiratory system, e g , b\ EPI-109 4 inhalation or other means, so that they may reach the lungs without widespread systemic dissemination This permits the use of substantially lower doses of the agent of the mvention as compared with those admmistered by the prior art, systemically or by other generalized routes and, consequently, reduce undesirable side effects resulting from the agent's widespread distribution in the body. The agent(s) of this mvention has (have) been shown to reduce the amount of receptor protein expressed by the tissue These agents, thus, rather than merely interacting with their targets, e g a receptor, lower the number of target protems that other drugs may interact with In this manner, the present agent(s) afford(s) extremely high efficacy with low toxicity

The adenosme receptors discussed above are mere examples of the high power of the inventor's technology In fact, a large number of genes may be targeted in a similar manner by the present agent(s), to reduce or down-regulate protein expression By means of example, if the target disease or condition is one associated with impeded or reduced breathing, bronchoconstriction, chronic bronchitis, pulmonary bronchoconstriction and/or hypertension, chronic obstructive pulmonary disease (COPD), allergy, asthma, cystic fibrosis, respiratory distress syndrome, cancers, which either directly or by metastasis afflict the lung, the present method may be applied to a list of potential target mRNAs, which includes the targets listed in Table 1 below, among others

Table 1: Pulmonary Disease or Condition (Asthma/Inflammation) Targets

Nf6B Transcription Factor Interleukm-8 Receptor (IL-8 R)

Interleukm-5 Receptor (IL-5R) Interleukιn-4 Receptor (IL-4R)

Interleukιn-3 Receptor (IL-3R) Interleukm- 1 beta (IL-lbeta)

Interleukm- 1 β Receptor (IL- lbeta R) Eotaxin

Tryptase Major Basic Protem β2-adrenergιc Receptor Kinase Endothehn Receptor A

Endothehn Receptor B Preproendothelin

Bradykimn B2 Receptor (B2BR) IgE (High Affinity Receptor)

Interleukm- 1 (IL-1) Interleukm 1 Receptor (IL-1 R)

Interleukm-9 (IL-9) Interleukm-9 Receptor (IL-9 R)

Interleukm- 11 (IL-11) Interleukm- 11 Receptor (IL-11 R)

Inducible Nitric Oxide Synthase Cyclooxygenase (COX)

Intracellular Adhesion Molecule 1 (ICAM 1) Vascular Cellular Adhesion Molecule (VCAM)

Rantes Endothelial Leukocyte Adhesion Molecule (ELAM- 1 )

Cyclooxygenase-2 (COX-2) GM-CSF, Endothehn- 1

Monocyte Activating Factor Neutrophil Chemotactic Factor

Neutrophil Elastase Defensm 1,2,3

Muscaπnic Acetylchohne Receptors Platelet Activating Factor

Tumor Necrosis Factor 5-hpoxygenase

Phosphodiesterase IV Substance P

Substance P Receptor Histamine Receptor

Chymase CCR-1 CC Chemokme Receptor

Interleukm-2 (IL-2) Interleukm-4 (IL-4)

Interleukm- 12 (IL-12) Interleukm-5 (IL-5)

Interleukιn-6 (IL-6) Interleukm-7 (IL-7)

Interleukιn-8 (IL-8) Interleukm- 12 Receptor (IL-12R)

Interleukιn-7 Receptor (IL-7R) Interleukm- 1 (IL-1)

Interleukm- 14 Receptor (IL-14R) Interleukm- 14

CCR-2 CC Chemokme Receptor CCR-3 CC Chemokme Receptor

CCR-4 CC Chemokme Receptor CCR-5 CC Chemokme Receptor

Prostanoid Receptors GATA-3 Transcription Factor

Neutrophil Adherence Receptor MAP Kinase

Interleukιn-15 (IL-15) Interleukm- 15 Receptor (IL-15R)

Interleukm- 11 (IL-11) Interleukm- 11 Receptor (IL-11R)

NFAT Transcription Factors STAT 4

MlP-lα MCP-2

MCP-3 MCP-4

Cyclophillin (A, B, etc ) Phospholφase A2

Basic Fibroblast Growth Factor Metalloproteinase EPI-109

CSBP/p38 MAP Kinase Tryptase Receptor

PDG2 Interleukm-3 (IL-3)

Interleukm- 10 (IL-10) Cyclosporm A - Binding Protein

FK506-Bmdmg Protein α4βl Selectm

Fibronectm α4β7 Selectm cMad CAM-1 LFA-1 (CD 11 a/CD 18)

PEC AM- 1 LFA-1 Selectm

C3bι PSGL-1

E-Selectm P-Selectm

CD-34 L-Selectm pl50,95 Mac-1 (CDl lb/CDlδ)

Fucosyl transferase VLA-4

CD-18/CDl la CDl lb/CD18

ICAM2 and ICAM3 C5a

CCR3 (Eotaxin Receptor) CCR1 , CCR2, CCR4, CCR5

LTB-4 AP-1 Transcription Factor

Protem kinase C Cystemyl Leukotπene Receptor

Tachykinnen Receptors (tach R) IκB Kinase 1 & 2

Interleukιn-2 Receptor (IL-2R) (e.g., Substance P, NK-1 & NK-3 Receptors)

STAT 6 c-mas

NF-Interleukιn-6 (NF-IL-6) Interleukm- 10 Receptor (IL-1 OR)

Interleukιn-3 (IL-3) Interleukιn-2 Receptor (IL-2R)

Interleukm- 13 (IL-13) Interleukm- 12 Receptor (IL-12R)

Interleukm- 14 (IL-14) Interleukm-6 Receptor (IL-6R)

Interleukm- 16 (IL-16) Interleukm- 13 Receptor (IL-13R)

Medullasm Interleukm- 16 Receptor (IL-16R)

Adenosme A, Receptor (A, R) Tryptase-I

Adenosme A_2b Receptor (A_2b R) Adenosme A₃ Receptor (A₃ R) β Tryptase

Adenosme A_2a Receptor (A^ R) IgE Receptor β Subumt (IgE R β)

Fc-epsilon receptor CD23 antigen IgE Receptor Subumt (IgE R α)

IgE Receptor Fc Epsilon Receptor (IgERFc ζ R) Substance P Receptor

Histidine decarboxylase Tryptase- 1

Prostaglandm D Synthase Eosmophil Cationic Protem

Eosinophil Derived Neurotoxin Eosinophil Peroxidase

Endothelial Nitric Oxide Synthase Endothelial Monocyte Activating Factor

Neutrophil Oxidase Factor Cathepsin G

Macrophage Inflammatory Prote - 1- Interleukιn-8 Receptor α Subumt (IL-8 R )

Alpha/Rantes Receptor Substance P Endothehn Receptor ET-B Endothelin ETA Receptor

Examples ot other targets are 5-lιpoxygenase, α-Rantes receptor, Cathepsin G, CCR-1 CC Chemokme receptor, CCR-1 CC Chemokme receptor, CCCR-5 CC Chemokme receptor,, CD-11-CDl la, c-Mas, Endothelial Nitric Oxide Synthase, Endothelial receptor ET B, Endothelin 1 , Eosmophil Cationic Proetin, Eosinophil Derived Neurotoxin, Fc-e receptor II (CD 23 Antigen), Histidine Decarboxylase, Interleukm 10 (IL- 10), IL-10 receptor, IL-11 receptor, IL-12, IL-12 receptor, IL-13, IL-13 receptor, IL-14 and its receptor, IL-15 and its receptor, IL-16 and its receptor, IL-6 and its receptor, IL-7 and its receptor, Intracellular Adhesion Molecule -2 (ICAM-2), ICAM-3, Medullasm, Neurokιnιn-3 receptor (NK-3 R), Neutrophil Oxidase Factor, Platelet Activating Factor receptor, Prostaglandm D Synthase, Protein Kinase c, P-Selectin Glycoprotein Ligand 1 (PSGL-1), Tryptase Activated receptor, IL-2 and its receptor, IL-3 and its receptor, IL-4 and its receptor, IL-5 and its receptor, IL-8 and its receptor, IL-9 and its receptor, Intracellular adhesion Molecule- 1 , Leukocyte Adhesion Glycoprotein, Leukotπene C-4 Synthase, Major Basic Protem, MCP-3, Monocyte Asctuatmg Factor, Muscaπnic Acetylcholme receptors, Neurokmιn-1 Receptor, Neutrophil Chemotactic Factor, Neutrophil Elastase, NfKB, Phosphodiesterase IV Prostaglandm Receptor, P-selectin, Rantes, Stat-1 , Stat-2, Stat 3, Substance P and its receptor, Tryptase, Tumor Necrosis Factor A, Vascular Cellular Adhesion Molecule, AP-1 Transcription Factor, Basic Fibroblast Growth Factor, C5a, CCR-2 CC Chemokme Receptor, CSBP-p38 MAP Kinase, EPI-109 6

Cyclooxygenase-2 (COX-2), Cyclophilin (A, B, C, and the rest), Cyclosporin A Binding Protein, Cysteinyl Leukotriene Receptor, E-Selectin, Fibronectin, Fusosyl Transferase, GATAS-3 Transcription Factor, Granulocyte-Macrophage Stimulating Factor (GM-CSF), Histamine Receptor, 1KB Kinase 1 and 2, nterleukin 7, L-Selectin, Mac-1 (CDl lb and CD18), Mad CAM-1, Map Kinase, MCP-4, Metalloproteinase, MlP-la, Neutrophil Adherence Receptors, NFAT Transcription Factors, NF-Interleukin-6 (NF-IL-6), Pecam- l.Phospholipase A2, Prostanoid Receptors, Stat-4, Stat-6, VLA-4, and others.

The oligos of this invention may be obtained by first selecting fragments of a target nucleic acid having at least 4 contiguous nucleic acids selected from the group consisting of G and C, and then obtaining a first oligonucleotide 4 to 60 nucleotides long which comprises the selected fragment and has a C and G nucleic acid content of up to and including about 15% . The latter step may be conducted by obtaining a second oligonucleotide 4 to 60 nucleotides long comprising a sequence which is anti-sense to the selected fragment, the second oligonucleotide having an adenosine base content of up to and including about 15%. This method may also comprise, when the selected fragment comprises at least one thymidine base, substituting an adenosine base in the corresponding nucleotide of the anti-sense fragment with a universal base selected from the group consisting of heteroaromatic bases which bind to a thymidine base but have antagonist activity and less than about 0.3 of the adenosine base agonist activity at the adenosine A,, A_2b and A₃ receptors, and heteroaromatic bases which have no activity or have an agonist activity at the adenosine A_2a receptor. The analogue heteroaromatic bases may be selected from all pyrimidines and purines, which may be substituted by O, halo, NH₂, SH, SO, S0₂, S0₃, COOH and branched and fused primary and secondary amino, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkoxy, alkenoxy, acyl, cycloacyl, arylacyl, alkynoxy, cycloalkoxy, aroyl, arylthio, arylsulfoxyl, halocycloalkyl, alky ley cloalkyl, alkenylcycloalkyl, alkynylcycloalkyl, haloaryl, alkylaryl, alkenylaryl, alkynylaryl, arylalkyl, arylalkenyl, arylalkynyl, arylcycloalkyl, which may be further substituted by O, halo, NH₂, primary, secondary and tertiary amine, SH, SO, S0₂, S0₃, cycloalkyl, heterocycloalkyl and heteroaryl. The pyrimidines and purines may be substituted at all positions as is known in the art, but preferred are those which are substituted at positions 1, 2, 3, 4, 7 and/or 8. More preferred are pyrimidines and purines such as theophylline, caffeine, dyphylline, etophylline, acephylline piperazine, bamifylline, enprofylline and xantine having the chemical formula

O ^" H I I I

l ' I I ft

wherein R¹ and R² are independently H, alkyl, alkenyl or alkynyl and R³ is H, aryl, dicycloalkyl, dicycloalkenyl, dicycloalkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, O-cycloalkyl, O-cycIoalkenyl, O-cycloalkynyl, NH₂- alkylamino-ketoxyalkyloxy-aryl, mono and dialkylaminoalkyl-N-alkylamino-S0₂ aryl, among others.

The inventor reduced the adenosine content of the anti-sense oligos corresponding to the thymidines (T) present in the target RNA to less than about 15%, or fully eliminated A from the oligonucleotide sequence as a means for preventing their breakdown products from freeing adenosine into the lung tissue environment and, thereby, aggravating the subject's ailment and/or countering the beneficial effect of the administered agent.

By means of example, the Nf6B transcription factor may be selected as a target, and its mRNA or DNA searched for low thymidine (T) or desthymidine (desT) fragments. Only desT segments of the mRNA or DNA are selected which, in turn, will produce desA anti-sense as their complementary strand. When a number of RNA desT segments are found, the sequence of the anti-sense segments may be deduced. Typically, about 10 to 30 and even larger numbers of desA anti-sense sequences may be obtained. These anti-sense sequences may include some or all desA anti-sense oligonucleotide sequences corresponding to desT segments of the mRNA of the target, such as anyone of those shown in Table 1 above or Table 2 below. When this occurs, the anti-sense oligonucleotides found are said to be 100% A-free. For each of the original desA anti-sense oligonucleotide sequences corresponding to the target gene, e.g. the NF6B transcription factor, typically about 10 to 30 sequences EPI-109 7 may be found within the target gene or RNA which have a low content of thymidine (RNA) In accordance with this invention, the selected fragment sequences may also contam a small number of thymidine (RNA) nucleotides within the secondary or tertiary or quaternary sequences In some cases, a large adenosme content may suffice to render the anti-sense oligonucleotide less active or even mactive agamst the target. In accordance with this invention, these so called A non-fully desA sequences may preferably have a content of adenosine of less than about 15% , more preferably less than about 10%, and still more preferably less than 5%, and some even less than 2% adenosine. In some instances a higher content of adenosme is acceptable and the oligonucleotides are still active, particularly where the adenosme nucleotide may be Afixed® or replaced with a AUniversal® base that may base-pair with similar or equal affinity to two or more of the four nucleotide present m natural DNA A, G,

C, and T. A universal base is defined m this patent as any compound, more commonly an adenosine analogue, having the capacity to hybridize to thymidine, preferably having substantially reduced, or substantially lackmg, ability to bind adenosine receptors. Alternatively, adenosine analogs which do not activate adenosine receptors, such as the adenosme A,, A_{2 b} and/or A₃ receptors, most preferably A, receptors, may be used. One example of a universal base is α-deoxyπbofuranosol-(5-nιtroιndole), and an artisan will know how to select others This Afixmg® step generates a further novel sequence, different from the one found in nature, that permits the anti- sense oligonucleotide to bind, preferably equally well, with the target RNA An example of a universal base is 2- deoxyπbosyl-(5-nιtromdole) Other examples of universal bases are 3-nιtropyrrole-2'-deoxynucleosιde, 5-nιtro- mdole, 2-deoxyπbosyl-(5-mtroιndole), 2-deoxyπbofuranosyl-(5-nιtroιndole), 2'-deoxyιnosιne, 2'- deoxynebulaπne, 6H, 8H-3,4-dιhydropyπmιdo [4,5-c] oxazιne-7-one and 2-amιno-6-methoxyamιnopuπne In addition to the above, Universal bases which may be substituted tor any other base although with somewhat reduced hybridization potential, include 3-nιtropyrrole 2'-deoxynucleosιde 2-deoxyπbofuranosyl-(5-nιtroιndole), 2'-deoxyιnosme and 2 '-deoxynebularme (Glen Research, Sterling, VA). More specific mismatch repairs may be made using "P" nucleotide, 6H, 8H-3, 4-dthydropyπmιdo[4,5-c] [1 ,2] oxazm-7-one, which base pairs with either guanine (G) or adenine (A) and "K" nucleotide, 2-amιno-6-methoxyamιnopuπne, which base pairs with either cytidine (C) or thymidine (T), among others Others which are known m the art are also suitable See, for example, Loakes, D. and Brown, D. M., Nucl .Acids Res. 22:4039-4043 (1994), Ohtsuka, E. et al , J. Biol. Chem.260(5).2605-2608 (1985); Lin, P.K.T. and Brown, D. M., Nucleic Acids Res. 20(19).5149-5152 (1992, Nichols, R. et al., Nature 369(6480): 492-493 (1994), Rahmon , M S. and Humayun, N. Z., Mutation Research 377 (2). 263-8 (1997); Amosova, O., et al., Nucleic Acids Res. 25 (!0). 1930-1934 (1997); Loakes D & Brown,

D. M , Nucleic Acids Res. 22 (20) 4039-4043 (1994), the entire sections relatmg to universal bases and their preparation and use in nucleic acid bmdmg is inceorporated herein by reference.

When non-fully desT sequences are found in the naturally occurring target, they typically are selected so that about 1 to 3 universal base substitutions will suffice to obtain a 100% AdesA® anti-sense oligonucleotide Thus, the present method provides either anti-sense oligonucleotides to different targets which are low in, or devoid of, A content, as well as anti-sense oligonucleotides where one or more adenosme nucleotides, e g about 1 to 3, or more, may be Afixed® by replacement with a AUniversal® base. Universal bases are known in the art and need not be listed herein. An artisan will know which bases may act as universal bases, and replace them tor A.

The present approach to the design of anti-sense oligonucleotide approach is also applicable to a variety of other diseases or conditions, including other inflammatory diseases, such as cystic fibrosis, chronic obstructive pulmonary disease, chronic bronchitis, pulmonary hypertension, cancers, including those which metastasize to the lung, such as breast cancer, colon cancer, respiratory distress syndrome, prostate cancer, pancreatic cancer, kidney cancer, lymphomas, melanomas, hepatocellular carcinomas, etc

As used herein, the term "treat" or "treating" asthma or other respiratory and inflammatory conditions or diseases refers to a treatment which decreases the likelihood that the subject admmistered such treatment will manifest symptoms of a respiratory or inflammatory lung disease or other lung conditions The term "down- regulate" refers to mducmg a decrease m production, secretion or availability (and thus a decrease in concentration) of the targeted intracellular protem.

The present mvention is concerned primarily with the treatment of vertebrates, and within this group, of mammals, including human and non-human simians, wild and domesticated animals, marme and land animals, household pets, and zoo animals, for example, felmes, canines, equines, pachiderms, cetaceans, and still more preferably to human subjects. One particularly suitable application of this technology is for veterinary purposes, EPI-109 8 and includes all types of small and large animals in the care of a veterinarian, including wild animals, marine animals, household animals, zoo animals, and the like Targeted genes and proteins are preferably mammalian, and the sequences targeted are preferably of the same species as the subject being treated Although in many instances, targets of a different species are also suitable, particularly those segments of the target RNA or gene that display greater than about 45% homology, preferably greater than about 85% homology, still more preferably greater than about 95% homology, with the recipient's sequence A preferable group of agents is composed of des-A anti-sense oligos Another preferred group is composed of non-fully desA oligonucleotides, where one or more adenosme bases are replaced with universal bases

The terms "anti-sense" oligonucleotides generally refers to small, synthetic oligonucleotides, resemblmg single-stranded DNA, which m this patent are applied to the inhibition of gene expression by inhibition of a target messenger RNA (mRNA) See, Milhgan, J F et al , J Med Chem 36(14), 1923-1937 (1993), the relevant portion of which is hereby incorporated in its entirety by reference The present agents inhibit gene expression of target genes, such as those of the adenosine A, A_2a, A_2b, or A₃ receptors, CCR3 (chemical receptor 320, also known as the eotaxm receptor), VCAM (vascular cell adhesion molecule), eonophil receptor, bradykimn 2B receptor, and many others listed in Table 1 above This is generally attained by hybridization of the anti-sense oligonucleotides to coding (sense) sequences ot a targeted messenger RNA (mRNA), as is known in the art The exogenously administered agents of the invention decrease the levels of mRNA and protein encoded by the target gene and/or cause changes m the growth characteristics or shapes of the thus treated cells See, Milhgan et al (1993), Helene C and Toulme, J Biochim Biophys Acta 1049, 99 125 (1990), Cohen, J S D , Ed , Ohgodeoxynucleotides as Anti sense Inhibitors of Gene Expression, CRC Press Boca Raton, FL (1987), the relevant portion of which is hereby incorporated in its entirety by reference As used herein, anti-sense oligonucleotide" is generally a short sequence of synthetic nucleotide that (1) hybridizes to any segment of a mRNA encodmg a targeted protein under appropriate hybridization conditions, and which (2) upon hybridization causes a decrease in gene expression of the targeted protem

The terms Ades-adenosme® (desA) and Ades-thymidme® (desT) refer to oligonucleotides substantially lackmg either adenosme (desA) or thymidine (desT) In some instances, the des T sequences are naturally occurring, and in others they may result from substitution of an undesirable nucleotide (A) by another one lacking its undesirable activity In the present context, the substitution is generally accomplished by substitution of A with a Auniversal base®, as is known in the art

The mRNA sequence of the targeted protem may be derived from the nucleotide sequence of the gene expressing the protein For example, the sequence of the genomic human adenosine A, receptor and that of the rat and human adenosine A₃ receptors are known See, US Pat No 5,320,962, Zhou, F , et al , Proc Nat' l Acad Sci (USA) 89 7432 (1992), Jacobson, M A , et al , U K Pat Appl No 9304582 1 The sequence of the adenosine A,_b receptor gene is also known See, Salvatore, C A , Luneau, C J , Johnson, R G and Jacobson, M , Genomics (1995), the relevant portion of which is hereby incorporated m its entirety by reference The sequences of many of the exemplary target genes are also known See, GenBank, NIH The sequences of those genes whose sequences are not yet available may be obtained by isolating the target segments applying technology known in the art Once the sequence of the gene, its RNA and/or the protein are known, an anti-sense oligonucleotides may be produced according to this invention as described above to reduce the production of the targeted protein in accordance with standard techniques

In one aspect of this invention, the anti-sense oligonucleotide has a sequence which specifically binds to a portion or segment of an mRNA molecule which encodes a protem associated with a disease or condition associated with impeded breathing, lung inflammation, airway obstruction, bronchitis, and the like One effect of this binding is to reduce or even prevent the translation of the correspondmg mRNA and, thereby, reduce the available amount of target protem in the subject's lung

In one preferred embodiment of this invention, the phosphodiester residues of the anti-sense oligonucleotide are modified or substituted Chemical analogs of oligonucleotides with modified or substituted phosphodiester residues, e g , to the methylphosphonate, the phosphotπester, the phosphorothioate, the phosphorodithioate, or the phosphoramidate, which increase the m vivo stability of the oligonucleotide are particularly preferred The naturally occurrmg phosphodiester linkages of oligonucleotides are susceptible to some degree of degradation bv cellular nucleases Many of the residues proposed herein, on the contrary are highly resistant to nuclease degradation See Milhgan et al , and Cohen, J S D , supra In another preferred EPI-109 9 embodiment of the invention, the oligonucleotides may be protected from degradation bv adding a ' 3' end cap' by which nuclease-resistant linkages are substituted for phosphodiester linkages at the 3' end of the oligonucleotide See, Tidd, D M and Warenius, H M , Be J Cancer 60 343-350 (1989), Shaw, J P et al , Nucleic Acids Res 19 747-750 (1991), the relevant section of which are incorporated m their entireties herein by reference Phosphoramidates, phosphorothioates, and methylphosphonate linkages all function adequately in this manner for the purposes of this invention The more extensive the modification of the phosphodiester backbone the more stable the resulting agent, and in many instances the higher their RNA affinity and cellular permeation See Milhgan, et al , supra Thus, the number of residues which may be modified or substituted will vary depending on the need, target, and route of admmistration, and may be from 1 to all the residues, to any number m between Many different methods for replacing the entire phosphodiester backbone with novel linkages are known See, Millikan et al, supra Preferred backbone analogue residues mclude phosphorothioate, methylphosphonate, phosphotπester, thioformacetal, phosphorodithioate, phosphoramidate, formacetal boranophosphate, 3 '-thioformacetal, 5'-thioether, carbonate, 5'-N-carbamate, sulfate, sulfonate, sulfamate, sulfonamide, sulfone, sulfite , 2'-0 methyl, sulfoxide, sulfide, hydroxy lamine, methylene(methylimmo) (MMI), and methyleneoxy(methylιmιno) (MOMI) residues Phosphorothioate and methylphosphonate-modified oligonucleotides are particularly preferred due to their availability through automated oligonucleotide synthesis See, Millikan et al, supra Where appropπate, the agent of this invention may be administered in the form of their pharmaceutically acceptable salts, or as a mixture of the anti-sense oligonucleotide and its salt In another embodiment of this invention a mixture of different anti-sense oligonucleotides or their pharmaceutically acceptable slats is administered

The agents ot this invention have the capacity to attenuate the expression of one target mRNA and/or to enhance or attenuate the activit) of one pathway By means of example, the present method may be practiced by identifying all possible deoxyπbonucleotide segments which are low in thymidine (T) or deoxynucleotide segments low in adenosine (A) of about 7 or more mononucleotides, preferably up to about 60 mononucleotides, more preferably about 10 to about 36 mononucleotides, and still more preferably about 12 to about 21 mononucleotides, m a target mRNA or a gene, respectively This may be attamed by searching for mononucleotide segments within a target sequence which are low in, or lack thymidine (RNA), a nucleotide which is complementary to adenosine, or that are low in adenosine (gene), that are 7 or more nucleotides long In most cases, this search typically results in about 10 to 30 such sequences, I e naturally lackmg or having less than about 40% adenosine, anti-sense oligonucleotides of varying lengths for a typical target mRNA of average length, l e , about 1800 nucleotides long Those with high content of T or A, respectively, may be fixed by substitution of a universal base for one or more As

The agent(s) of this invention may be of any suitable length, including but not limited to, about 7 to about 60 nucleotides long, preferably about 12 to about 45, more preferably up to about 30 nucleotides long, and still more preferably up to about 21 , although they may be of other lengths as well, depending on the particular target and the mode of delivery The agent(s) of the invention may be directed to any and all segments of a target RNA One preferred group of agent(s) includes those directed to an mRNA region containing a junction between an intron and an exon Where the agent is directed to an intron/exon junction, it may either entirely overlie the junction or it may be sufficiently close to the junction to inhibit the splicmg-out of the intervenmg exon during processing of precursor mRNA to mature mRNA, e g with the 3' or 5' terminus of the anti-sense oligonucleotide being positioned within about, for example, within about 2 to 10, preferably about 3 to 5, nucleotide of the intron/exon junction Also preferred are anti-sense oligonucleotides which overlap the initiation codon, and those near the 5' and 3' termini of the coding region

Table 2 below provides a selected number of targets to which the agents of the invention are effectively applied Others, however, may also be targeted EPI-109 10

Table 2: Cancer Targets

Transforming Therapy

Oncogenes Targets ras thymidylate synthetase src thymidylate synthetase myc dihydrofolate reductase bcl-2 thymidine kinase deoxycytidrne kinase πbonucleotide reductase

A group of preferred targets for the treatment of cancer are genes associated with any of different types of cancers, or those generally known to be associated with malignancies, whether they are regulatory or involved in the production of RNA and/or proteins Examples are transforming oncogenes, including, but not limited to, ras, src, myc, and bcl 2, among others Other targets are those to which present cancer chemotherapeutic agents are directed to, such as various enzymes, primarily, although not exclusively, thymidylate synthetase dihydrofolate reductase, thymidine kinase, deoxycytidrne kinase, πbonucleotide reductase, and the like

The present technology is particularly useful in the treatment of cancer ailments given that traditional cancer therapies are fraught with the unresolved problem of selectively killing cancer cells while preserving normal living cells from the devastating effects of treatments such as chemotherapy, radiotherapy, and the like The present technology provides the ability ot selectively attenuating or enhancing a desired pathway or target This approach provides a significant advantage over standard treatments of cancer because it sermits the selection of a pathway, includmg primary, secondary and possibly tertiary targets, which are not generally expressed simultaneously m normal cells Thus, the present agent may be admmistered to a subject to cause a selective mcrease m toxicity within tumor cells that, for instance, express all three targets while normal cells that may expresses only one or two of the targets will be significantly less affected or even spared

A group of preferred targets for the treatment of cancers are genes associated with different types of cancers, or those generally known to be associated with malignancies, whether they are regulatory or involved in the production of RNA and/or proteins Examples are transforming oncogenes, including, but not limited to, ras, src, myc, and bcl 2, among others Other targets are those to which present cancer chemotherapeutic agents are directed to, such as various enzymes, primarily although not exclusively, thymidylate synthetase, dihydrofolate reductase, thymidine kinase, deoxycytidrne kinase, πbonucleotide reductase, and the like

In one embodiment, at least one of the mRNAs to which the MTA oligo of the mvention is targeted encodes a protein such as transcription factors, stimulating and activatmg factors, intracellular and extracellular receptors and peptide transmitters in general, interleukins, interleukm receptors, chemokmes, chemokme receptors, endogenously produced specific and non-specific enzymes, immunoglobulins, antibody receptors, central nervous system (CNS) and peripheral nervous and non-nervous system receptors, CNS and peripheral nervous and non-nervous system peptide transmitters, adhesion molecules, defensmes, growth factors, vasoactive peptides and receptors, and binding proteins, among others, or the mRNA is correspondmg to an oncogene and other genes associated with various diseases or conditions

Examples of target protems are eotaxin, major basic protein, preproendothehn, eosinophil cationic protein, P-selectm, ST AT 4, MlP-lα, MCP-2, MCP-3, MCP-4, STAT 6, c-mas, NF-IL-6, cyclophil ns, PDG2, cyclospoπn A-bmding protein, FK5-bιndmg protem, fibronectin, LFA-1 (CDl la/CD18), PECAM-1 , C3bι, PSGL-l ,CD-34, substance P, pl50,95, Mac-1 (CDllb/CD18), VLA-4, CD-18/CDl la, CDl lb/CD18, C5a, CCR1 , CCR2, CCR4, CCR5, and LTB-4, among others Others are, however, suitable, as well

In another embodiment, at least one of the mRNAs to which the MTA oligo is targeted encodes intracellular and extracellular receptors and peptide transmitters such as sympathomimetic receptors, parasympathetic receptors, GABA receptors, adenosine receptors, bradykimn receptors, insulin receptors, glucagon receptors, prostaglandm receptors, thyroid receptors, androgen receptors, anabolic receptors estrogen receptors, progesterone receptors, receptors associated with the coagulation cascade, adenohypophyseal receptors, EPI-109 1 1 adenohypophyseal peptide transmitters, and histamme receptors (HisR), among others However others are also contemplated

The encoded sympathomimetic receptors and parasympathomimetic receptors include acetylcholmesterase receptors (AcChaseR) acetylcholine receptors (AcChR), atropine receptors, muscarmic receptors, epmephπne receptors (EpiR), dopamine receptors (DOPAR), and norepinephrme receptors (NEpiR), among others Further examples of encoded receptors are adenosme A, receptor, adenosine A₂B receptor, adenosine A₃ receptor, endothelin receptor A, endothellin receptor B, IgE high affinity receptor, muscarmic acetylcholine receptors, substance P receptor, histamme receptor, CCR-1 CC chemokme receptor, CCR-2 CC chemokme receptor, CCR-3 CC chemokme receptor (Eotaxm Receptor), mterleukin-lβ receptor (IL-lβR), ιnterleukm-1 receptor (IL-1R), interleukin-lβ receptor (IL-lβR), ιnterleukιn-3 receptor (IL-3R), CCR-4 CC chemokme receptor, cysteinyl leukotπene receptors, prostanoid receptors, GATA-3 transcription factor receptor, ιnterleukm-1 receptor (IL-1R), ιnterleukιn-4 receptor (IL-4R), mterleukm-5 receptor (IL-5R), ιnterleukιn-8 receptor (IL-8R), mterleukιn-9 receptor (IL-9R), ιnterleukιn-11 receptor (IL-11R), bradykimn B2 receptor, sympathomimetic receptors, parasympathomimetic receptors, GAB A receptors, adenosine receptors, bradykimn receptors, insulin receptors, glucagon receptors, prostaglandm receptors, thyroid receptors, androgen receptors, anabolic receptors, estrogen receptors, progesterone receptors, receptors associated with the coagulation cascade, adenohypophyseal receptors, and histamme receptors (HisR) Others are also contemplated even though not listed herein

The encoded enzymes for development of the MTA oligos of the invention include synthetases, kinases, oxidases, phosphatases, reductases, poly saccharide, tπglyceπde, and protem hydrolases, esterases, elastases, and , poly saccharide, tπglyceπde, lipid, and protem synthases, among others Examples of target enzymes are tryptase, inducible nitric oxide synthase, cyclooxygenase (Cox), MAP kinase, eosmophil peroxidase, β2- adrenergic receptor kinase, leukotπene c-4 synthase, 5-lιpooxygenase, phosphodiesterase IV, metalloproteinase, tryptase, CSBP/p38 MAP k ase, neutrophil elastase, phospholipase A2, cyclooxygenase 2 (Cox-2), fucosyl transferase, chymase, protein kinase C, thymidylate synthetase, dihydrofolate reductase, thymidine kmase, deoxycytidrne kinase, and ribonucleotide reductase, among others Any enzyme associated with a disease or condition , however, is suitable as a target for this invention.

Suitable encoded factors for application of this mvention are, among others, Nf6B transcription factor, granulocyte macrophage colony stimulating factor (GM-CSF), AP-1 transcription factor, GATA-3 transcription factor, monocyte activating factor, neutrophil chemotactic factor, granulocyte/macrophage colony-stimulatmg- tactor (G-CSF), NFAT transcription factors, platelet activating factor, tumor necrosis factor α (TNF α), and basic fibroblast growth factor (BFGF) Additional factors are also withm the invention even though not specifically mentioned

Suitable adhesion molecules for use with this invention include intracellular adhesion molecules 1 (ICAM-1), 2 (ICAM-2) and 3 (ICAM-3), vascular cellular adhesion molecule (VCAM), endothelial leukocyte adhesion molecule- 1 (ELAM-1), neutrophil adherence receptor, mad CAM-1 , and the like Other known and unknown factors (at this time) may also be targeted herein

Among the cytokmes, lymphokines and chemokines preferred are interleukin- 1 (IL-1), interleukm- lβ (IL-l)mterleukιn-3 (IL-3), ιnterleukιn-4 (IL-4), mterleukm-5 (IL-5), mterleukιn-8 (IL-8), ιnterleukιn-9 (IL-9), interleukm- 11 (IL-l l),CCR-5 CC chemokme, and Rantes Others, however, may also be targeted, as they are known to be involved in specific diseases or conditions to be treated, or for their generic activities, such as inflammation

Examples of defensins tor the practice of this invention are defensm 1 , defensm 2, and defensin 3, and of selectms are α4βl selectm, 4β7 selectm, LFA-1 selectm, E-selectm, P-selectm, and L-selectm Examples of oncogenes, although not an all inclusive list, are ras, src, myc, and bcl-2 Others, however, are also suitable for use with this invention.

In another preferred embodiment, the composition and formulations further comprise one or more surfactants Suitable surfactants or surfactant components for enhancing the uptake of the anti-sense oligonucleotides of the invention mclude synthetic and natural as well as full and truncated forms of surfactant protem A, surfactant protein B, surfactant protein C, surfactant protem D and surfactant Protem E, di-saturated phosphatidylcho ne (other than dipalmitoyl), dipalmitoylphosphatidylcholine, phosphatidvlcholme phosphatidylglycerol, phosphatidylinositol, phosphatidylethanolamine, phosphatidylseπne, phosphatidic acid, EPI-109 12 ubiqumones , lysophosphatidy lethanolamme , lysophosphatidylcholine , palmitoy 1-lysophosphatιdylcholme , dehydroepiandrosterone, dohchols, sulfatidic acid, glycerol-3-phosphate, dmydroxyacetone phosphate, glycerol, glycero-3-phosphochohne, dihydroxy acetone, palrmtate, cytidine diphosphate (CDP) diacylglycerol, CDP choline, chohne, chohne phosphate, as well as natural and artificial lamelar bodies which are the natural carrier vehicles for the components of surfactant omega-3 fatty acids, polyenic acid, polyenoic acid, lecithin, palmitmic acid, non-ionic block copolymers of ethylene or propylene oxides, polyoxypropylene, monomeric and polymeric, polyoxyefhylene, monomeric and polymeric, poly (vinyl amine) with dextran and/or alkanoyl side chains, Bπj 35, Triton X-100 and synthetic surfactants ALEC, Exosurf, Survan and Atovaquone, among others However, others may also be employed These surfactants may be useed either as single or part of a multiple component surfactant in a formulation, or as covalently bound additions to the 5' and/or 3' ends ofthe anti-sense oligonucleotides (oligos)

The agents admmistered m accordance with this invention are preferably designed to be anti-sense to target genes and/or mRNAs related m origin to the species to which it is to be admmistered When treating humans, the agents are preferably designed to be anti-sense to a human gene or RNA The agents of the invention encompass oligonucleotides which are anti-sense to naturally occurring DNA and/or RNA sequences, fragments thereof of up to a length of one (1) base less than the targeted sequence, preferably at least about 7 nucleotides long, oligos having only over about 0 02% , more preferably over about 0 1 % , still more preferably over about 1 % , and even more preferably over about 4% adenosine nucleotides, and up to about 30%, more preferably up to about 15%, still more preferably up to about 10% and even more preferably up to about 5%, adenosine nucleotide, or lacking adenosine altogether and oligos in which one or more of the adenosine nucleotides have been replaced with so-called universal bases, which may pair up with thymidine nucleotides but fail to substantially trigger adenosine receptor activity Examples of human sequences and fragments, which are not limiting, of anti-sense oligonucleotide of the invention are the following fragments as well as shorter segments of the fragments and of the full gene or mRNA coding sequences, exons and mtron-exon junctions encompassing preferably 7, 10, 15, 18 to 21, 24, 27, 30, n-1 nucleotides for each sequence, where n is the sequence's total number of nucleotides These fragments may be selected from any portion of the longer oligo, for example, from the middle, 5'- end, 3'- end or starting at any other site of the original sequence Of particular importance are fragments of low adenosine nucleotide content, that is, those fragments containing less than or about 30%, preferably less than or about 15% , more preferably less than or about 10%, and even more preferably less than or about 5%, and most preferably those devoid of adenosine nucleotide, either by choice or by replacement with a universal base in accordance with this invention The agent of the invention includes as a most preferred group sequences and their fragments where one or more adenosines present m the sequence have been replaced by a universal base (B), as exemplified here Similarly, also encompassed are all shorter fragments of the B-containing fragments designed by substitution of B(s) for adenosιne(s) (A(s)) contamed in the sequences, fragments thereof or segments thereof, as described above A limited list of sequences and fragments is provided below

Some of the examples of anti-sense oligonucleotide sequence fragments target the initiation codon of the respective gene, and in some cases adenosine is substituted with a universal base adenosine analogue denoted as "B", which lacks ability to bind to the adenosine A, and/or A₃ receptors In fact, such replacement nucleotide acts as a "spacer" In fact, in all examples provided, whether it is an A or a B written m, either one of these may be substituted In fact, what this means is that if an A is present A denotes adenosine or any universal base which may substitute for it, and id B is written it also signifies adenosine or any universal base Many of the examples shown below provide one such sequence and many fragments overlappmg the initiation codon, preferably wherein the number of nucleotides n is about 7, about 10, about 12, about 15, about 18, about 21 and up to about 28, about 35, about 40, about 50, about 60 It may also be generally said that for the exemplary sequences B is adenosine or a universal base as well as an adenosine A2a receptor agonist, or adenosme Al , A2b or A3 receptor antagonist Human Receptor-related Antisense Polynucleotide

5 GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGGCTGGG C TGCTTTTCT TTTCTGGGCC TCTGTGGTCT GTTTTTTTCT GGCCCTGCTG GGGCGCTCTC CGCCGCCCGC CTGGCTCCCG GBGCCCBTGB TGGGCBTGCC GTGGTTCTTG CCCTCCTTTG GCTGCCGTGC CCGCTCCCCG GCCTCCTGGC GGGTGGCCGT TGGGCCCGTG TTCCCCTGGG GCCTGGGGCT CCCTTCTCTC GCCCTTCTTG CTGGGCCTCT GCTGCTGCTG GTGCTGTGGC CCCCGTACA CCGAGGAGCC CATGATGGGC ATGCCACAGA CGACAGGCGT BCBCCGBGGB GCCCBTGBTG GGCBTGCCBC BGBCGBCBGG C GGC GCC GTG CCG CGT CTT GGT GGC GGC GG GTT CGC GCC CGC GCG GGG CCC CTC CGG TCC GTT CGC GCC CGC GCG GGG CCC EPI-109 13

CTC CGG TCC CGG GTC GGG GCC CCC CGC GGC C GCC TCG GGG CTG GGG CGC TGG TGG CCG GG CCG CGC CTC CGC CTG CCG CTT CTG GCT GGG CCC CGG GCG CCC CCT CCC CTC TTG CTC GGG TCC CCG TG ACA GCG CGT CCT GTG TCT CCA GCA GCA TGG CCG GGC CAG CTG GGC CCC BCB GCG CGT CCT GTG TCT CCB GCB GCB TGG CCG GGC CBG CTG GGC CCC ACA GAG CAG TGC TGT TGT TGG GCA TCT TGC CTT CCC AGG G BCB GBG CB TGC TGT TGT TGG GCB TCT TGC CTT CCC BGG GCC CTT TTC TGG TGG GGT GGT GCT GTT GTT GGG CTT TCT TCT GTT CCC BCB GBG CBG TGC TGT TGT TGG GCB TCT TGC CTT CCC BGG GCC CTT TTC TGG TGG GGT GGT GCT GTT GTT GGG C TTT CTT CTG TTC CC TTT CCC CTG GGT CTT CC CTC CTG CTC TTT TTT C ATT TGC TCT CCT ATT ACT TTC TGT GTC CAT TTT TTC ATT AAC CGA GCT GT BTT TGC TCT CCT BTT BCT TTC TGT GTC CBT TTT TTC BTT BBC CGB GCT GT GCC TGT GTC TGT CCT CCT GCT TCG TTC CTC TCG TTC CTG CTT GGT GCC CTT GCC G GTC CTG CTC CTC CGG GCT GTG G GTC GTG GCC CTG GCT CCG GCT GGT GGG CTC CCC TGG CCT TCG CTG GCT GGC GGC GTG C GGG TCT TGC TCT GGG CCT GGC TGT GGC CGT GGT TGG GGG TCT TC GCT GCC TCC GTT TGG GTG GC TCT CTG AAT ATT GAC CTT CCT CCA TGG CGG TCC TGC TTG GAT TCT CCC GA TCT CTG BBT BTT GBC CTT CCT CCB TGG CGG TCC TGC TTG GBT TCT CCC GB GCC TTT CCT GGT TCT CTT GTT GTT TTT GGG GTT TGG CTT ACA GTA GAG TAG GGG ATT CCA TGG CAG GAG CCA TCT TCT TCA TGG ACT CC TTC AAG GAG ACC TTA GGT TTC TGA GGG ACT GCT AAC ACG CCA TCT GGA GC BCB GTB GBG TBG GGG BTT CCB TGG CBG GBG CCB TCT TCT TCB TGG BCT CC TTC BBG GBG BCC TTB GGT TTC TGB GGG BCT GCT BBC BCG CCB TCT GGB GC GTT GTT TTT GGG GTT TGG CTT GCC TTT CCT GGT TCT CTT BCB GTB GBG TBG GGG BTT CCB TGG CBG GBG CCB TCT TCT TCB TGG BCT CC TTC BBG GBG BCC TTB GGT TTC TGB GGG BCT GCT BBC BCG CCB TCT GGB GC GCC TGT GTC TGT CCT CCT GCT TCG TTC CTC TCG TTC CTG CTT GGT GCC CTT GCC G GTC CTG CTC CTC CGG GCT GTG G GTC CTC GCC CTG GCT CCG GCT GGT GGG CTC CCC TGG CCT TCG CTG GCT GGC GGC GTG C CCC BGB BCG BGB CCC GGB CCG BCB GGC CGT GGT TGG GGG TCT TC GCT GCC TCC GTT TGG GTG GC GAT CTC TGA ATA TTGA CCT TCC ATG GCG GTC CTG CTT GGA GBT CTC TGB BTB TTGB CCT TCC BTG GCG GTC CTG CTT GGB TCT GGG GTG TCC TGG CCT TCG TGG TTC CTC TTC CTT CGT TTG CCG TCC GCG GGG GCC CCC GGG CCT GGC TGC GCT CCT GCC CCG CCT CTT TCC CGG GCT CTT GCG CTG GGG GGT GCT CC CGT GTG TTT GCG CCC TC CTC CTG GTC GCG CTT GTC GTT TTG GGG CCG GCT TTG CCC GCC TCC CGG CGC CTG GCC CGG CC TTC CTG GGC TGC GTG CGC GTT CTG TTC TTC TTC CTG GCT CTG GGG TGT CCT GGC CTT CGT GGT TCC TCT TCC TTC GTT TGC CGT CCG CGG GGG CCC CCG GGC CT GGC TGC GCT CCT GCC CCG CCT CTT TCC CGG GCT CTT GCG CTG GGG GGT GCT CCC GTG TGT TTG CGC CCT CCT CCT GGT CGC GCT TGT CGT TTT GG GGC CGG CTT TGC CCG CCT CCC GGC GCC TGG CCC GGC CTT CCT GGG CTG CGT GCG CGT TCT GTT CTT CTT CCT GGC GCA GGA GAC AGG GCA GGG CGA TCA GGA GCA GCG TGA GCC AAA GGA GGA CCA TCG GGA ACG CAG CTC CGG AAC GCA GGA CAG AGG TGC C GC BGG BGB CBG GGC BGG GCG BTC BGG BGC BGC GTG BGC CBB BGG BGG BCC BTC GGG BBC GCB GCT CCG GBB CGC BGG BCB GBG GTG CC TCT GCC CTG TCC GCC GGC TCT TCG GTG GCT CGG CCC CGC TCC TTG TCT TGC CGC GGG TTG GTT CCT GGG CCT GGT TCT TGC GGG CGT TTC GGT CTG CTG GCT GGT CTG GGC CCG CGG TGC GGC GGG TGG CTT GCT GTT CTG CCT GGG CTC TCC CCT CTC CTC CTT TTC TCC CTT CCT CTG TCT TGC CTC CTT CCT CTG GGT CCT CTT GGC CTG GGC GCT CTT CCC CTC GGG CGG CTG CGG GCG CTC GTG CTG CCT GGT CCG CTC CCT GGG GGT GCT CCT TCC CTT TCC CCG CTC GTG GGG TTT GCG GGG CTG GGC TGC CCT GGG GGG TCT GGG CCT TTT GGG GTC GGC TGG CTG CTG CTT CGG GCC GCC TGG GCT TCC CTG TGC CCC TTT CCT CTG CTG GGT CCC CCT CCC GTT CCA AGC TGC ACC GCA CAG ACC GGC GCT ACA GGA CAG AGC CAG GCA AGC ACC CAT GGG GAT CCA GGC CCA GCT GTT CCB BGC TGC BCC GCB CBG BCC GGC GCT BCB GGB CBG BGC CBG GCB BGC BCC CBT GGG GBT CCB GGC CCB GCT G CTCAGTGGCC CCCAAAAGGA TGAGTAATAC ATGCGCCACG ATGATCATAT CCTTTTTACT ATGAGGCCGT GTCTGTCGTG TCTTTCCTTT GCTCTTGGTG TGTCTTTGCT GTGCCCTGCC TCTCTGCCCG TGTCTGTCGT GTCTTTCCTT TGCTCTTGGT GTGTCTTTGC TGTGCCCTGC CTCTCTGCC CGTGTCTGTC GTGTCTTTCC TTTGCTCTTG GTGTGTCTTT GCTGTGCCCT GCCTCTCTGC GGGGGTGGCT TCCTGCCGCG TCTCTGGGCC GTCCCGTCCC TCGGCCCCGC GCCGCGCTCG GCTCCTCTCC CTCTGGCCCG GCTCGGGGCG GGGCGGGGCG GTGGGCGGGC GGCGCTGCCC TGCGCGCGGC GCTGGCCCCT GCTGGCCGTC GGCTGCGCGC TGCTGGCTGC CCTGCTGGCC GCGCCGGGGC CTGTCCGCCT CTGCGGGCGC TGTCTCCTGG CTTGTCTTCC GGCTCTTCTG CTGGGGTGGG GCTGGGCGGC CGGCCCGGTG CTGGGGCTCC TCGGGGGGGG GGGCTCTTCC GGGCTGTCTC CCTCCGGGGC GGGGGTTTCT GGCCGTGGGG GTCTTGCCTG GCCTCCGGGC TCCTGCTTGT CTTGCCTTCC TTCTCTGGTC GGTTGTGGCT CGGGGCTCCG TGGGTCCCTG GCGCCCGTTT GTGTTTTGTC TTTTCCCCTG GCGTCCCTGT GCCCCTCTCC TCTCCTTCCT CTGCTTCTCG CTCTCCTTTG TGGGGCCCTC CCTGCTGCTC TTGGTTTTGG GCTTTTTTTC TCTTCCTCCT TTTTCGTGCG TGGGCCTCC GCACGCCTCT TGCCACCTCC TGCGCAGGGC AGCGCCTTGG GGCCAGCGCC GCTCCCGGCG CGGCCAGCAG GGCAGCCAGC AGCGCGCAGC CGACGGCCAG CATGCTTCCT CCTCGGCTAC CACTCCATGG TCCCGCAGAG GCGGACAGGC GCBCGCCTC TTGCCBCCTC CTGCGCBGGG CBGCGCCTTG GGGCCBGCGC CGCTCCCGGC GCGGCCBGCB GGGCBGCCBG CBGCGCGCBG CCGBCGGCCB GCBTGCTTCC TCCTCGGCTB CCBCTCCBTG GTCCCGCBGB GGCGGBCBGG C GCTGCCCGGC GGGGTGTGCG CTTGGCGCTC CCGTGCTCGG TTCTCTGTCT CCCGGTCCCC CTTGCCTGGC GTCTCGGGCC TTCGTCCTCT TCCTCTTCTT CCTTCCGCTC CGTGGGGGCT GCTTGGTGGG GGCCTGTGCCT CGGGGTCCCG GGGCTTCTGG CCCTTGCCGT TCATGGTGGC TAGGTGGGGC GTTCBTGGTG GCTBGGTGGG GC GGG GTG GGT BGG CCG TGT CTG GGGGTT GGC CBT GTT GGT TGC CTCT TGG TGG TGC GCC GGG CGCG TCT TGG CTT TCT TCT CCT TCG GGC CCT CGG GCC GGT GCT TGT GGGCT CCT CCC GGG CGG CCT CCC CGG GCG GGG GCT TCT TGGCG CTG GCG GGG GGG CCT CCTGCT CTG TGG CTG GGC GTT CCT TGG TGT TCT GGG TGGTGG CGG GCG TGG TGG CCT CTG TGGGGG CCC GCG GCT GCB GGG GTTG CCT GTC TGC TTC GTCCTT TGC GCT CCC GGG CCG CCGGG GTG GGT AGG CCG TGT CTG GGGGTT GGC CAT GTT GGT TGC CGGG CCC GCG GCT GCA GGG G ACAGGGGCTG TAATCTTCATC EPI-109 14

TGCAGGTGGC ATGCCAGTGA AATTTAGATC ATCAAAATCC CACATCTGTG GATCTGTAAT ATTTGACATG TCCTCTTCAG TTTCAGCAAT GGTTTGATCT AACTGAAGCA CCGGCCAGGB CBGGGGCTGT BBTCTTCBTC TGCBGGTGGC BTGCCBGTGB BBTTTBGBTC BTCBBBBTCC CBCBTCTGTG GBTCTGTBBT BTTTGBCBTG TCCTCTTCBG TTTCBGCBB TGGTTTGBTC TBBCTGBBGC BCCGGCCBGG TGGCTCGGTG CTTCTGCCCC TGTTGTTGCG GCGCTCGGTT GGTGTGGCCC CTGTGGTGCT TCGTTTCCCC CTCTTTCTCT TTGTTCGGGG GTTCTTGTGG CGGGCTGCTT GTCTCGTTCC GCCCTGTCGG GCGGGAAGCC TCTCTCCTCT CCCCAGATC CGCGACAGGC CGCAGGCAAG AACCAGCGCA ACCAGGGCGC GTCCGCACAG ACTTGGAGGC GGCTGCATGC TGCTACCTGC TCCAGAAGCG TCCGGTGGCC GCCGCGCC CTGTCGGGCG GGBBGCCTCT CTCCTCTCCC CBGBTCCGCG BCBGGCCGCB GGCBBGBBCC BGCGCBBCCB GGGCGCGTCC GCBCBGBCTT GGBGGCGGCT GCBTGCTGCT BCCTGCTCGGGCG GGBBGCCTCCG GTGGCCGCCG CGCGTCCGGT GGCCGCCGCG CCTCTCTCCT CTCCCCGTGG CCCTGTCGGG CGGGTCCTGC CGTCCTGTCT CCTTTTCTTT TGCTGTCTTG TCTTCCCGTC TCTGCTTT GTCTGTCCTC CCCGTCTCCT CCCACTGCTT CTCCCGGGGG CTTCCCCGGC TTCGGGTGGC CGGTGTCCCG GGCTCCGGCG CGGCGGCGGC TTCGGCTGCG GGTGGGTGGC GCGGGCTGCC GGGTCCGCGC GGCGCCTGGG CCCTTGTGCT GCTTTTTGCT TGTTCCGTTC TGGCTGCTCC GGTCTGTGTT GTGGTTGTTT TGTTTCTTCT TGGGTGTGGG CCTTGCGGTT TTGGCTGTGG GCCCTTTGGG GCCTTGGCTT CTGGCTCGTC TGTCCTCCCC GTCTCCTCCC ACTGCTTCT CCCGGGGGCT TCCCCGGCTT CGGGTGGCCG GTGTCCCGGG CTCCGGCGCG GCGGCGGCTT CGGCTGCGGG TGGGTGGCGC GGGCTGCCGG GTCCGCGCGG CGCCTGGGCC CTTGTGCTGC TTTTTGCTTG TTCCGTTCTG GCTGCTCCGG TCTGTGTTGT GGTTGTTTTG TTTCTTCTTG GGTGTGGGCC TTGCGGTTTT GGCTGTGGGC CCTTTGGGGC CTTGGCTTCT GGCTCCAT CCACATGATT GCTTAGATTT GTGCTGTATC TCTCAGGATT ATCACTGATT ACACATCCAA CCAGTGCCAG CCAAAAGGAT GCCCTGAGGC AAAGGGTTTC CATCTTGAGG CAAATTTGAG GACBTCCBC BTGBTTGCTT BGBTTTGTGC TGTBTCTCTC BGGBTTBTCB CTGBTTBCBC BTCCBBCCBG TGCCBGCCBB BBGGBTGCCC TGBGGCBBBG GGTTTCCBTC TTGBGGCBBB TTTGBGGBGGGCTBBGBT GBTCCBCBTC BCTBCCBCGT TGCCCBCCBC BGBGGTCBCC BCBBTGBCCG TGTBGGCBGC TGCCCBBBGG BCBBTTTGCC BGGCTGGTTG CBCGBBCTGB TTGGGTTCCG BGGTGTTBGT GGBGBTGTTT GGGGBGBGGT CTGBGTCCBC CGGGBGGBCG TTBTCCBTTT CGBBGCTBGG CGGTBBBGCC CTBCTBTCTG TBCBCBBCCC CCCTCTGCBG CBGBGTCCTG TCGTGGCGCC TGGGGCTCBG GGTCCGGGC TAAGATGATC CACATCACTA CCACGTTGCC CACCACAGAG GTCACCACAA TGACCGTGTA GGCAGCTGCC CAAAGGACAA TTTGCCAGGC TGGTTGCACG AACTGATTGG GTTCCGAGGT GTTAGTGGAG ATGTTTGGGG AGAGGTCTGA GTCCACCGGG AGGACGTTAT CCATTTCGAA GCTAGGCGGT AAAGCCCTAC TATCTGTACA CAACCCCCCT CTGCAGCAGA GTCCTGTCGT GGCGCCTGGG GCTCAGGGTC CGTCCTGTCG TGGCGCCTGG GGCTCTTCTT TTGTGGGCTC TTTGGTGGCT GTGGCTGTGG TCTCTGTGGT TGCTGCCCTG GGTCTGGGGG TGTGGCCTTG GGGCCGTCCT CTGGCTCCTC CTCGTGGGCC CCC GGTGBCBTTG BGCBTGTCGG CGCGGTCCCG TTBBGBGTGG GCCCGCCAGC CCAGCCACTC CACTTGGGGG CGGGTGGCCA GCACGAACAG CACCCAGAGG AAGGGGGGCG GCCCAGAAGG GCAGCCCGCA GGCCAGGATC AGGTCTGCTG CGGCCGGAGA TAATGGCATT CACCACGCGG CGGCCCAGCG CACGCCGCGC ATCCGGCCCG GGTTCTGACC TGCAGCCCCC GTCTCCTTGG CATTCCTGGG CCCCAGTCAC TCCTCTCCCT GCCCCCCTTG CTGGGGCAGG GACGGGGTG BCBTTGBGCB TGTCGGCGCG GTCCCGTTBB GBGTGGGCCC GCCAGCCCAG CCACTCCACT TGGGGGCGGG TGGCCAGCAC GAACAGCACC CAGAGGAAGG GGGGCGGCCC AGAAGGGCAG CCCGCAGGCC AGGATCAGGT CTGCTGCGGC CGGAGATAAT GGCATTCACC ACGCGGCGGC CCAGCGCACG CCGCGCATCC GGCCCGGGTT CTGACCTGCA GCCCCCGTCT CCTTGGCATT CCTGGGCCCC AGTCACTCCT CTCCCTGCCC CCCTTGCTGG GGCAGGGACG GCCGTGTTGT CBGTGGTGCT GCCCGTTTGB GGTBTGGCGC TCCBCCBBTT CCCTTTTCTC CTTGTTTTCC GTTTCTCTTG CCGTCTGTGG TT ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTTCTGCTT CATCGTCTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG CCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCCTCTTTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA G ATGAGTGTCA GAAGTGTGAA GGGTGCCTGT TCTGAATCCC AGAGCCTCCT CTCCCTCTGT GAGGCTGGCA GGTGAGGAAG GGTTTAACCT CACTGGAAGG AATCCCTGGA GCTAGCGGCT GCTGAAGGCG TCGAGGTGTG GGGGCACTTG GACAGAACAG TCAGGCAGCC GGGAGCTCTG CCAGCTTTGG TGACCTTGGG CCGGGCTGGG AGCGCTGCGG CGGGAGCCGG AGGACTATGA GCTGCCGCGC GTTGTCCAGA GCCCAGCCCA GCCCTACGCG CGCGGCCCGG AGCTCTGTTC CCTGGAACTT TGGGCACTGC CTCTGGGACC CCTGCCGGCC AGCAGGCAGG ATGGTGCTTG CCTCGTGCCC CTTGGTGCCC GTCTGCTGAT GTGCCCAGCC TGTGCCCGCC ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTTCTGCTT CATCGTGTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT EPI-109 15

CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCCTCTTTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA GACCCCGCCT TCCGCTCCCA CCAGCCCACA TCCAGTGGGG TCTCAGTCCA GTCCTCACAT GCCCGCTGTC CCAGGGGTCT CCCTGAGCCT GCCCCAGCTG GGCTGTTGGC TGGGGGCATG GGGGAGGCTC TGAAGAGATA CCCACAGAGT GTGGTCCCTC CACTAGGAGT TAACTACCCT ACACCTCTGG GCCCTGCAGG AGGCCTGGGA GGGCAAGGGT CCTACGGAGG GACCAGGTGT CTAGAGGCAA CAGTGTTCTG AGCCCCCACC TGCCTGACCA TCCCATGAGC AGTCCAGCGC TTCAGGGCTG GGCAGGTCCT GGGGAGGCTG AGACTGCAGA GGAGCCACCT GGGCTGGGAG AAGGTGCTTG GGCTTCTGCG GTGAGGCAGG GGAGTCTGCT TGTCTTAGAT GTTGGTGGTG CAGCCCCAGG ACCAAGCTTA AGGAGAGGAG AGCATCTGCT CTGAGACGGA TGGAAGGAGA GAGGTTGAGG ATGCACTGGC CTGTTCTGTA GGAGAGACTG GCCAGAGGCA GCTAAGGGGC AGGAATCAAG GAGCCTCCGT TCCCACCTCT GAGGACTCTG GACCCCAGGC CATACCAGGT GCTAGGGTGC CTGCTCTCCT TGCCCTGGGC CAGCCCAGGA TTGTACGTGG GAGAGGCAGA AAGGGTAGGT TCAGTAATCA TTTCTGATGA TTTGCTGGAG TGCTGGCTCC ACGCCCTGGG GAGTGAGCTT GGTGCGGTAG GTGCTGGCCT CAAACAGCCA CGAGGTGGTA GCTCTGAGCC CTCCTTCTTG CCCTGAGCTT TCCGGGGAGG AGCCTGGAGT GTAATTACCT GTCATCTGGG CCACCAGCTC CACTGGCCCC CGTTGCCGGG CCTGGACTGT CCTAGGTGAC CCCATCTCTG CTGCTTCTGG GCCTGATGGA GAGGAGAACA CTAGACATGC CAACTCGGGA GCATTCTGCC TGCCTGGGAA CGGGGTGGAC GAGGGAGTGT CTGTAAGGAC TCAGTGTTGA CTGTAGGCGC CCCTGGGGTG GGTTTAGCAG GCTGCAGCAG GCAGAGGAGG AGTACCCCCC TGAGAGCATG TGGGGGAAGG CCTTGCTGTC ATGTGAATCC CTCAATACCC CTAGTATCTG GCTGGGTTTT CAGGGGCTTT GGAAGCTCTG TTGCAGGTGT CCGGGGGTCT AGGACTTTAG GGATCTGGGA TCTGGGGAAG GACCAACCCA TGCCCTGCCA AGCCTGGAGC CCCTGTGTTG GGGGGCAAGG TGGGGGAGCC TGGAGCCCCT GTGTGGGAGG GCGAGGCGGG GGAGCCTGGA GCCCCTGTGT GGGAGGGCGA GGCGGGGGAT CCTGGAGCCC CTGTGTCGGG GGGCGAGGGA GGGGAGGTGG CCGTCGGTTG ACCTTCTGAA CATGAGTGTC AACTCCAGGA CTTGCTTCCA AGCCCTTCCC TCTGTTGGAA ATTGGGTGTG CCCTGGCTCC CAAGGGAGGC CCATGTGACT AATAAAAAAC TGTGAACCCT CGCATTTGTG TTTTAATAAA AGAATCTGGA AGATAAATAG TCTTGAAGAG AGACAAAGGA AGGAAAATTT AAATCCTTAG ATTCAAGCAG AAGAATTCCA TGTGGAAGGT TTGGGTTGTT GTTGTTGTTG TTTGGTGTGT TTTTTGTTTT TTTGTTTTTT TGTTTTTTTT TGAGATGGAG TCTCGCTGTG TTACCGGGAG CGACAGAGCC GCACGGCCGA GTCGAGTCCC AGCCAGCTAC CATCCCTCTG GAGCTTACCG GCCGGCCTTG GCTTCCCCAG GAATCCCTGG AGCTAGCGGC TGCTGAAGGC GTCGAGGTGT GGGGGCACTT GGACAGAACA GTCAGGCAGC CGGGAGCTCT GCCAGCTTTG GTGACCTTGG GTGCTTGCCT CGTGCCCCTT GGTGCCCGTC TGCTGATGTG CCCAGCCTGT GCCCGCCATG CCGCCCTCCA TCTCAGCTTT CCAGGCCGCC TACATCGGCA TCGAGGTGCT CATCGCCCTG GTCTCTGTGC CCGGGAACGT GCTGGTGATC TGGGCGGTGA AGGTGAACCA GGCGCTGCGG GATGCCACCT TCTGCTTCAT CGTGTCGCTG GCGGTGGCTG ATGTGGCCGT GGGTGCCCTG GTCATCCCCC TCGCCATCCT CATCAACATT GGGCCACAGA CCTACTTCCA CACCTGCCTC ATGGTTGCCT GTCCGGTCCT CATCCTCACC CAGAGCTCCA TCCTGGCCCT GCTGGCAATT GCTGTGGACC GCTACCTCCG GGTCAAGATC CCTCTCCGGT ACAAGATGGT GGTGACCCCC CGGAGGGCGG CGGTGGCCAT AGCCGGCTGC TGGATCCTCT CCTTCGTGGT GGGACTGACC CCTATGTTTG GCTGGAACAA TCTGAGTGCG GTGGAGCGGG CCTGGGCAGC CAACGGCAGC ATGGGGGAGC CCGTGATCAA GTGCGAGTTC GAGAAGGTCA TCAGCATGGA GTACATGGTC TACTTCAACT TCTTTGTGTG GGTGCTGCCC CCGCTTCTCC TCATGGTCCT CATCTACCTG GAGGTCTTCT ACCTAATCCG CAAGCAGCTC AACAAGAAGG TGTCGGCCTC CTCCGGCGAC CCGCAGAAGT ACTATGGGAA GGAGCTGAAG ATCGCCAAGT CGCTGGCCCT CATCCTCTTC CTCTTTGCCC TCAGCTGGCT GCCTTTGCAC ATCCTCAACT GCATCACCCT CTTCTGCCCG TCCTGCCACA AGCCCAGCAT CCTTACCTAC ATTGCCATCT TCCTCACGCA CGGCAACTCG GCCATGAACC CCATTGTCTA TGCCTTCCGC ATCCAGAAGT TCCGCGTCAC CTTCCTTAAG ATTTGGAATG ACCATTTCCG CTGCCAGCCT GCACCTCCCA TTGACGAGGA TCTCCCAGAA GAGAGGCCTG ATGACTAGAC CCCGCCTTCC GCTCCCACCG CCCACATCCA GTGGGGTCTC AGTCCAGTCC TCACATGCCC GCTGTCCCAG GGGTCTCCCT GAGCCTGCCC CAGCTGGGCT GTTGGCTGGG GGCATGGGGG AGGCTCTGAA GAGATACCCA CAGAGTGTGG TCCCTCCACT AGGAGTTAAC TACCCTACAC CTCTGGGCCC TGCAGGAGGC CTGGGAGGGC AAGGGTCCTA CGGAGGGACC AGGTGTCTAG AGGCAACAGT GTTCTGAGCC CCCACCTGCC TGACCATCCC ATGAGCAGTC CAGAGCTTCA GGGCTGGGCA GGTCCTGGGG AGGCTGAGAC TGCAGAGGAG CCACCTGGGC TGGGAGAAGG TGCTTGGGCT TCTGCGGTGA GGCAGGGGAG TCTGCTTGTC TTAGATGTTG GTGGTGCAGC CCCAGGACCA AGCTTAAGGA GAGGAGAGCA TCTGCTCTGA GACGGATGGA AGGAGAGAGG TTGAGGATGC ACTGGCCTGT TCTGTAGGAG AGACTGGCCA GA CCCAGCCCCG AGGCTCAGAA GCGGCAGGCG GAGGCGCGGT

CCGGGCGCTA TGGCCATGCC CGGCGGGTCT CACGCGGCTG CCCCTCGCCC GGCGCGCCTT CGGTAGGGGG CGCCCGGGGC CCAGCTGGCC CGGCCATGCT GCTGGAGACA CAGGACGCGC TGTACGTGGC GCTGGAGCTG GTCATCGCCG CGCTTTCGGT GGCGGGCAAC GTGCTGGTGT GCGCCGCGGT GGGCACGGCG AACACTCTGC AGACGCCCAC CAACTACTTC CTGGTGTCCC TGGCTGCGGC CGACGTGGCC GTGGGGCTCT TCGCCATCCC CTTTGCCATC ACCATCAGCC TGGGCTTCTG CACTGACTTC TACGGCTGCC TCTTCCTCGC CTGCTTCGTG CTGGTGCTCA CGCAGAGCTC CATCTTCAGC CTTCTGGCCG TGGCAGTCGA CAGATACCTG GCCATCTGTG TCCCGCTCAG GTATAAAAGT TTGGTCACGG GGACCCGAGC AAGAGGGGTC ATTGCTGTCC TCTGGGTCCT TGCCTTTGGC ATCGGATTGA CTCCATTCCT GGGGTGGAAC AGTAAAGACA GTGCCACCAA CAACTGCACA EPI-109 16

GAACCCTGGG ATGGAACCAC GAATGAAAGC TGCTGCCTTG TGAAGTGTCT CTTTGAGAAT GTGGTCCCCA TGAGCTACAT GGTATATTTC AATTTCTTTG GGTGTGTTCT GCCCCCACTG CTTATAATGC TGGTGATCTA CATTAAGATC TTCCTGGTGG CCTGCAGGCA GCTTCAGCGC ACTGAGCTGA TGGACCACTC GAGGACCACC CTCCAGCGGG AGATCCATGC AGCCAAGTCA CTGGCCATGA TTGTGGGGAT TTTTGCCCTG TGCTGGTTAC CTGTGCATGC TGTTAACTGT GTCACTCTTT TCCAGCCAGC TCAGGGTAAA AATAAGCCCA AGTGGGCAAT GAATATGGCC ATTCTTCTGT CACATGCCAA TTCAGTTGTC AATCCCATTG TCTATGCTTA CCGGAACCGA GACTTCCGCT ACACTTTTCA CAAAATTATC TCCAGGTATC TTCTCTGCCA AGCAGATGTC AAGAGTGGGA ATGGTCAGGC TGGGGTACAG CCTGCTCTCG GTGTGGGCCT ATGATCTAGG CTCTCGCCTC TTCCAGGAGA AGATACAAAT CCACAAGAAA CAAAGAGGAC ACGGCTGGTT TTCATTGTGA AAGATAGCTA CACCTCACAA GGAAATGGAC TGCCTCTCTT GAGCACTTCC CTGGAGCTAC CACGTATCTA GCTAATATGT ATGTGTCAGT AGTAGCACCA AGGATTGACA AATATATTTA TGATCTATTC AGCTGCTTTT ACTGTGTGGA TTATGCCAAC AGCTTGAATG GATTCTAACA GACTCTTTTG TTTTTAAAAG TCTGCCTTGT TTATGGTGGA AAATTACTGA AACTATTTTA CTGTGAAACA GTGTGAACTA TTATAATGCA AATACTTTTT AACTTAGAGG CAATGGAAAA ATAAAAGTTG ACTGTACTAA AAATGTATAC TTGTTGCCAG GAAGGTGACC TCAAAAATTA AAAGTATAAT TATTCGGCCG GGCATGGTGG CTCACACCTG TAATTCCAGC ACTTTGGGAG GCCAAGGCAG GCGGATCACG AGGTCAGGAG TTCAAAACCA GCCTGTCCAA TATAGTG GGGCAATTTG TTAGTTATCC GCCGCCACCA AGACGCGGCA CGGCGCCTGG ACCGGAGGGG CCCCGCGCGG GCGCGAACTT TGGGCTCGGG CGAGTGGGTG GTGCTCCGCC CAGCCCGAGA CGGGCGGGCG CGCGGGCCAA TGGGTGCCGC CTCTTGGCCG CGGGGGGCCC CGACCCGTGG GTCCCGGCCA CCAGCGCCCC AGCCCCGAGG CTCAGAAGCG GCAGGCGGAG GCGCGGTCCG GGCGCTATGG CCATGCCCGG CGGGTCTCAC GCGGCTGCCC CTCGCCCGGC GCGCCTTCGG TAGGGGGCGC CCGGGGCCCA GCTGGCCCGG CCATGCTGCT GGAGACACAG GACGCGCTGT ACGTGGCGCT GGAGCTGGTC ATCGCCGCGC TTTCGGTGGC GGGCAACGTG CTGGTGTGCG CCGCGGTGGG CACGGCGAAC ACTCTGCAGA CGCCCACCAA CTACTTCCTG GTGTCCCTGG CTGCGGCCGA CGTGGCCGTG GGGCTCTTCG CCATCCCCTT TGCCATCACC ATCAGCCTGG GCTTCTGCAC TGACTTCTAC GGCTGCCTCT TCCTCGCCTG CTTCGTGCTG GTGCTCACGC AGAGCTCCAT CTTCAGCCTT CTGGCCGTGG CAGTCGACAG ATACCTGGCC ATCTGTGTCC CGCTCAGGTA TAAAAGTTTG GTCACGGGGA CCCGAGCAAG AGGGGTCATT GCTGTCCTCT GGGTCCTTGC CTTTGGCATC GGATTGACTC CATTCCTGGG GTGGAACAGT AAAGACAGTG CCACCAACAA CTGCACAGAA CCCTGGGATG GAACCACGAA TGAAAGCTGC TGCCTTGTGA AGTGTCTCTT TGAGAATGTG GTCCCCATGA GCTACATGGT ATATTTCAAT TTCTTTGGGT GTGTTCTGCC CCCACTGCTT ATAATGCTGG TGATCTACAT TAAGATCTTC CTGGTGGCCT GCAGGCAGCT TCAGCGCACT GAGCTGATGG ACCACTCGAG GACCACCCTC CAGCGGGAGA TCCATGCAGC CAAGTCACTG GCCATGATTG TGGGGATTTT TGCCCTGTGC TGGTTACCTG TGCATGCTGT TAACTGTGTC ACTCTTTTCC AGCCAGCTCA GGGTAAAAAT AAGCCCAAGT GGGCAATGAA TATGGCCATT CTTCTGTCAC ATGCCAATTC AGTTGTCAAT CCCATTGTCT ATGCTTACCG GAACCGAGAC TTCCGCTACA CTTTTCACAA AATTATCTCC AGGTATCTTC TCTGCCAAGC AGATGTCAAG AGTGGGAATG GTCAGGCTGG GGTACAGCCT GCTCTCGGTG TGGGCCTATG ATCTAGGCTC TCGCCTCTTC CAGGAGAAGA TACAAATCCA CAAGAAACAA AGAGGACACG GCTGGTTTTC ATTGTGAAAG ATAGCTACAC CTCACAAGGA AATGGACTGC CTCTCTTGAG CACTTCCCTG GAGCTACCAC GTATCTAGCT AATATGTATG TGTCAGTAGT AGGCTCCAAG GATTGACAAA TATATTTATG ATCTATTCAG CTGCTTTTAC TGTGTGGATT ATGCCAACAG CTTGAATGGA TTCTAACAGA CTCTTTTGTT TTTAAAAGTC TGCCTTGTTT ATGGTGGAAA ATTACTGAAA CTATTTTACT GTGAAACAGT GTGAACTATT ATAATGCAAA TACTTTTTAA CTTAGAGGCA ATGGAAAAAT AAAAGTTGAC TGTACTAAAA ATG GAATTCCCAG ATGGGCAGAG GTGGCTGGGC TGGTGACCCT AAGTGTGTCT CCTGCCTTTA TTCTCTCTAG TGGGTTATTC TTTCATGTGG TATCTTGCCT ACAGCATGCT GTGTTTGGAC ACAAACCCCT TTCCTTGGTT TCTCTGACCC AGCTGAGATG GACTGATTCC AAAAGAACTC ACCTATGTAC TGGGGTAGGG GAGGGAGGGT TTTTTGCAGT ATTTAACTAA GGTTCAAAGA GTGCTATATA GTGAGAAAGG CΠTCTTTTTT TTTITTTTTT TTTTTTGGCA GAGTGCTGCC TCCTAGAAAT TTCTCTTGGT AACTTCCTTC TCTGAAGCAC AGATAAAGAA AACAATTACA GTAGAAACAT TTATGAGGGA CACATTGGAG GCCGATGAAG CTTTTCAAGT TCCAGCAGTG CAGGGATGTG GGCAGAACTG ACATTGGAAA ATACTAGAAT GATGGAAATT CAGTTGGAGA GGACTGCCCT TTTTAATGTC TGGGGAGTCT GCTCAGGGAG AAATGACAAG TCTGGCGGGG ACAAGTATGG GATTTGGTAA GACTTGGATC AACTTGGGAT ACAGGGTGGG GGTCGGGAGT GGAATCAATG AATGATGCCA GAGCAGATCA ACTAACAAGA GGACCCTGAT GAGCCCCAGG CAGAGGCGTC TCCCTTATGC CCCACTCTGA AGTGTTTGTT AGTAAACACC AGAACGCCAT TGTTGTTACT GCTGAATTTT ATTTTGGGCT GTACATATTT AGATGCTTAA GGTAAAAATG ATAAAGCCCT CAAGCCACTG TGTGGGTTTG GGTCCAAGTG TTCCTTCTTG CTGCCTCTCT AACACGCCTG GTTAAAATAA TCCCTTTGGA TGGTGCTGAG AAGCACCTGA ACCAAGTGGG TCCCCAAATA ACAATGGCGT GCAAGTGTCT GGTTCCCAGA AGTTGGTGAC TAGGTAAGCA GCTTCAGGGA GAGGGGGCTG ATTCCCAGAC AGTCGCCTGT TCCTGCGGGG ATGGGGCTGA GGCTTGGGGA ATGTGGGCAG GAGGATATGC CATTTGATTC TGTTGCACAC GTTCTTTTCC CTTCTTTCTG TATGTCTGGT CATTCTGCTA TTCTGTCGTT CCTCACATAG GTTGGACATT GGCCGGCTGC CAGCATAAGT GCCAGTGTGA TTTTGCTAGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG TTTTTGCCCT TCTGAGCAGG GAATCTTTGC TTATCCCTTT GACCAAGGAT CTTTGCTGCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGGTTAGGA GGCTGCCACC AAAGTCTCTT TTTTGTTCCT CTGCTTCTCC CGTTTGCCTC CTTATCATGA GATCTTTTTG CTAAGCTGGC AGAAAGATTG CATAGTCAGT GCTTCCAGCT CTGCTCCCAC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC GAGCCTTCTC TATGCCACTC ATGGCTCCTC TTCTGCTCTT TCCATCTTTT TGCTGAGAGT TCTGAGCTCT GTACTTCCTC TTGGCCCATC TCACTTCCTG AAACACCCCT GAAGAGGGTT GCTTATCTTG ATGGAACTCA AAAAGCCAAA AAGCTGCAGG CAGAGGCGTT GAGGACATCT GTTTGGGGAA CTAAGAGCAG CAGCACTTTC AGATTCAGTC CATATAGAGC TGTCCTACAG CATTCTGGAA ACTTGAGGAT GTGCGGTGCA TAAAGGGGCT GGAAGTGACC CACCTGTGAT GAGCCCTTTC TAAGGAGAAG GGTTTCCAAG EPI-109 17

AGATCACCCC ACCAGAAAAG GGTAGGAATG AGCAAGTTGG GAATTTTAGA CTGTCACTGC ACATGGACCT CTGGGAAGAC GTCTGGCGAG AGCTAGGCCC ACTGGCCCTA CAGACGGATC TTGCTGGCTC ACCTGTCCCT GTGGAGGTTC CCCTGGGAAG GCAAGATGCC CAACAACAGC ACTGCTCTGT CATTGGCCAA TGTTACCTAC ATCACCATGG AAATTTTCAT TGGACTCTGC GCCATAGTGG GCAACGTGCT GGTCATCTGC GTGGTCAAGC TGAACCCCAG CCTGCAGACC ACCACCTTCT ATTTCATTGT CTCTCTAGCC CTGGCTGACA TTGCTGTTGG GGTGCTGGTC ATGCCTTTGG CCATTGTTGT CAGCCTGGGC ATCACAATCC ACTTCTACAG CTGCCTTTTT ATGACTTGCC TACTGCTTAT CTTTACCCAC GCCTCCATCA TGTCCTTGCT GGCCATCGCT GTGGACCGAT ACTTGCGGGT CAAGCTTACC GTCAGGTAGC CTGCGGCGTG GGGTGGGCAG CAATTGAGGC AGCTGGGAAA TGAGGCTACA AAGCCAGAGC CTGCTGAATT TTATTTTGGA CTGTACATAT TTAGATGCTT AAGGTAAAAA TGATAAAGCC CTCAAGCCAC TGTGTGGGTT GGGTCCAAGT GTTCCTTGCT GCTGCCTCTC TAACACGCCT GGTTAAAATA ATCCCTTTGG ATGGTGCTGA GAAGCACCTG AACCAAGTGG GTCCCCAAAT AACTATGGCG TGCAAGTGTC TGGTTCCCAG AAGTTGGTGA CTAGGTAAGC GACTCAGGGA GAGGGGCTGA TTCCCAGACA GTCGCCTGTT CCTGCTGGGA TGGGGCTGAG GCTTGGGGAA TGTGGGCAGG AGGATATGCC ATTTGATTCT GTTGCACACG TTCTTTTCCC TTCTTTCTGT ATGTCTGGTC ATTCTGCTAT TCTGTCGTTC CTCACATAGG TTGGACATTG GCCGGCTGCC AGCATAAGTG CCAGTGTGAT TTTGCTAGGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG TTTTTGCCCT TCTGAGCAGG GAATCTTTGC TTATCCCTTT GACCAAGGAT CTTTGCTCCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGGTTAGGA GGCTGCCACC AAAGTCTCTT TTTTGTTCCT CTGCTTCTCC CGTTTGCCTC CTTATCATGA GATCTTTTTG CTAAGCTGGC AGAAAGATTG CATAATCAGT GCTTCCAGCT CCGCTCCCAC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC GAGCCTTCTC TATGCCACTC ATGGCTCCTC TTCTGCTCTT TCCATCTTTT TGCTGAGAGT TACTGAGCTC TGTACTTCCT CTTGGCCCAT CTCACTTCCT GAAACACCCC TGAAGAGGGT TGCTTATCTT GATGGAACTC AAAAAGCCAA AAAGCTGCAG GCAGAGGCGT TGAGGACATC TGTTTGGGGA ACTAAGAGCA GCAGCACTTT CAGATTCAGT CCATATAGAG CTGTCCTACA GCATTCTGGA AACTTGAGGA TGTGCGGTGC ATAAAGGGGC TGGAAGTGAC CCACCTGTGA TGAGCCCTTT CTAAGGAGAA GGGTTTCCAA GAGATCACCC CACCAGAAAA GGGTAGGAAT GAGCAAGTTG GGAATTTTAG ACTGTCACTG CACATGGACC TCTGGGAAGA CGTCTGGCGA GAGCTAGGCC CACTGGCCCT ACAGACGGAT CTTGCTGGCT CACCTGTCCC TGTGGAGGTT CCCCTGGGAA GGCAAGATGC CCAACAACAG CACTGCTCTG CGAATTCGGG GGACATCTGT TTGGGGAACT AAGAGCAGCA GCACTTTCAG ATTCAGTCCA TATAGAGCTG TCCTACAGCA TTCTGGAAAC TTGAGGATGT GCGGTGCATA AACGGGCTGG AAGTGACCCA CCTGTGATGA GCCCTTTCTA AGGAGAAGGG TTTCCAAGAG ATCACCCCAC CAGAAAAGGG TAGGAATGAG CAAGTTGGGA ATTTTAGACT GTCACTGCAC ATGGACCTCT GGGAAGACGT CTGGCGAGAG CTAGGCCCAC TGGCCCTACA GACGGATCTT GCTGGCTCAC CTGTCCCTGT GGAGGTTCCC CTGGGAAGGC AAGATGCCCA ACAACAGCAC TGCTCTGTCA TTGGCCAATG TTACCTACAT CACCATGGAA ATTTTCATTG GACTCTGCGC CATAGTGGGC AACGTGCTGG TCATCTGCGT GGTCAAGCTG AACCCCAGCC TGCAGACCAC CACCTTCTAT TTCATTGTCT CTCTAGCCCT GGCTGACATT GCTGTTGGGG TGCTGGTCAT GCCTTTGGCC ATTGTTGTCA GCCTGGGCAT CACAATCCAC TTCTACAGCT GCCTTTTTAT GACTTGCCTA CTGCTTATCT TTACCCACGC CTCCATCATG TCCTTGCTGG CCATCGCTGT GGACCGATAC TTGCGGGTCA AGCTTACCGT CAGATACAAG AGGGTCACCA CTCACAGAAG AATATGGCTG GCCCTGGGCC TTTGCTGGCT GGTGTCATTC CTGGTGGGAT TGACCCCCAT GTTTGGCTGG AACATGAAAC TGACCTCAGA GTACCACAGA AATGTCACCT TCCTTTCATG CCAATTTGTT TCCGTCATGA GGATGGACTA CATGGTATAC TTCAGCTTCC TCACCTGGAT TTTCATCCCC CTGGTTGTCA TGTGCGCCAT CTATCTTGAC ATCTTTTACA TCATTCGGAA CAAACTCAGT CTGAACTTAT CTAACTCCAA AGAGACAGGT GCATTTTATG GACGGGAGTT CAAGACGGCT AAGTCCTTGT TTCTGGTTCT TTTCTTGTTT GCTCTGTCAT GGCTGCCTTT ATCTCTCATC AACTGCATCA TCTACTTTAA TGGTGAGGTA CCACAGCTTG TGCTGTACAT GGGCATCCTG CTGTCCCATG CCAACTCCAT GATGAACCCT ATCGTCTATG CCTATAAAAT AAAGAAGTTC AAGGAAACCT ACCTTTTGAT CCTCAAAGCC TGTGTGGTCT GCCATCCCTC TGATTCTTTG GACACAAGCA TTGAGAAGAA TTCTGAGTAG TTATCCATCA GAGATGACTC TGTCTCATTG ACCTTCAGAT TCCCCATCAA CAAACACTTG AGGGCCTGTA TGCCTGGGCC AAGGGATTTT TACATCCTTG ATTACTTCCA CTGAGGTGGG AGCATCTCCA GTGCTCCCCA ATTATATCTC CCCCACTCCA CTACTCTCTT CCTCCACTTC ATTTTTCCTT TGTCCTTTCT CTCTAATTCA GTGTTTTGGA GGCCTGACTT GGGGACAACG TATTATTGAT ATTATTGTCT GTTTTCCTTC TTCCCAATAG AAGAATAAGT CATGGAGCCT GAAGGGTGCC TAGTTGACTT ACTGACAAAA GGCTCTAGTT GGGCTGAACA TGTGTGTGGT GGTGACTCAT TTCCATGCCA TTGTGGAATT GAGCAGAGAA CCTGCTCTCG GAGGATGCCT AGGAGATGTT GGGAACAGAA GAAATAAACT GAGTTTAAGG GGGACTTAAA CTGCTGAATT C CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT GCCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAGCTTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT CTTTAATCTA TTCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA TTGAGCACTT GCTGTATATG CAGTATTGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCTTGAAGG AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTT TTATGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT EPI-109 18

ACTATAAGGA AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC GGTGTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTT CCACCTGTCA TTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCATTTGGAG AGAAGGCCAT GTCTTCAAAG TCTGATTTGT GATGAGGCAG AGGAAGATAT TTCTAATCGG TCTTGCCCAG AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG GCCTGCTCAG GGACTGTTCC TGTCTCAGCA ACCAAGGGAT TGTTCCTGTC AATCAATGGT TTATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGTGT TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT AAATGAATAT TTATTAGCTG GTTGGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA ACCTAGAAGG GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGTTA GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATTTACAT GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAAT TTTAAAGCAA AAGCGTGAAA AAAAAGATTC CCTCCTTACC CCCAACCCAC TCTTTTTTCC CACCACCCAC TCTCCTCTGC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATTTAGTATT AGTATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC TGTGTTTTGT CACACAGGGC AGTCATTCAG CACCAGAGCA CGTGATGGTC TGAGACTCTC TTAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC TGTCCTGTGA AAGACTCAAT GAGCTGTTAT GTTGTAAACA GGAAGCATTT CACATCCAAA CGAGAAAATC ATGTAAACAT GTGTCTTTTC TGTAGAGCAT AATAAATGGA TGAGGTTTTT GCAAAAAAAA AAAAAAAAA ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTTCTGCTT CATCGTCTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCCTCTTTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA G ATGAGTGTCA GAAGTGTGAA GGGTGCCTGT TCTGAATCCC AGAGCCTCCT CTCCCTCTGT GAGGCTGGCA GGTGAGGAAG GGTTTAACCT CACTGGAAGG AATCCCTGGA GCTAGCGGCT GCTGAAGGCG TCGAGGTGTG GGGGCACTTG GACAGAACAG TCAGGCAGCC GGGAGCTCTG CCAGCTTTGG TGACCTTGGG CCGGGCTGGG AGCGCTGCGG CGGGAGCCGG AGGACTATGA GCTGCCGCGC GTTGTCCAGA GCCCAGCCCA GCCCTACGCG CGCGGCCCGG AGCTCTGTTC CCTGGAACTT TGGGCACTGC CTCTGGGACC CCTGCCGGCC AGCAGGCAGG ATGGTGCTTG CCTCGTGCCC CTTGGTGCCC GTCTGCTGAT GTGCCCAGCC TGTGCCCGCC ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTTCTGCTT CATCGTGTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCCTCTTTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA GACCCCGCCT TCCGCTCCCA CCAGCCCACA TCCAGTGGGG TCTCAGTCCA GTCCTCACAT GCCCGCTGTC CCAGGGGTCT CCCTGAGCCT GCCCCAGCTG GGCTGTTGGC TGGGGGCATG GGGGAGGCTC TGAAGAGATA CCCACAGAGT GTGGTCCCTC CACTAGGAGT TAACTACCCT ACACCTCTGG GCCCTGCAGG AGGCCTGGGA GGGCAAGGGT CCTACGGAGG GACCAGGTGT CTAGAGGCAA CAGTGTTCTG AGCCCCCACC TGCCTGACCA TCCCATGAGC AGTCCAGCGC TTCAGGGCTG GGCAGGTCCT GGGGAGGCTG AGACTGCAGA GGAGCCACCT GGGCTGGGAG AAGGTGCTTG GGCTTCTGCG GTGAGGCAGG GGAGTCTGCT TGTCTTAGAT GTTGGTGGTG CAGCCCCAGG ACCAAGCTTA AGGAGAGGAG AGCATCTGCT CTGAGACGGA TGGAAGGAGA GAGGTTGAGG ATGCACTGGC CTGTTCTGTA GGAGAGACTG GCCAGAGGCA GCTAAGGGGC AGGAATCAAG GAGCCTCCGT TCCCACCTCT GAGGACTCTG GACCCCAGGC CATACCAGGT GCTAGGGTGC CTGCTCTCCT TGCCCTGGGC CAGCCCAGGA TTGTACGTGG GAGAGGCAGA AAGGGTAGGT TCAGTAATCA TTTCTGATGA TTTGCTGGAG TGCTGGCTCC ACGCCCTGGG GAGTGAGCTT GGTGCGGTAG GTGCTGGCCT CAAACAGCCA EPI-109 19

CGAGGTGGTA GCTCTGAGCC CTCCTTCTTG CCCTGAGCTT TCCGGGGAGG AGCCTGGAGT GTAATTACCT GTCATCTGGG CCACCAGCTC CACTGGCCCC CGTTGCCGGG CCTGGACTGT CCTAGGTGAC CCCATCTCTG CTGCTTCTGG GCCTGATGGA GAGGAGAACA CTAGACATGC CAACTCGGGA GCATTCTGCC TGCCTGGGAA CGGGGTGGAC GAGGGAGTGT CTGTAAGGAC TCAGTGTTGA CTGTAGGCGC CCCTGGGGTG GGTTTAGCAG GCTGCAGCAG GCAGAGGAGG AGTACCCCCC TGAGAGCATG TGGGGGAAGG CCTTGCTGTC ATGTGAATCC CTCAATACCC CTAGTATCTG GCTGGGTTTT CAGGGGCTTT GGAAGCTCTG TTGCAGGTGT CCGGGGGTCT AGGACTTTAG GGATCTGGGA TCTGGGGAAG GACCAACCCA TGCCCTGCCA AGCCTGGAGC CCCTGTGTTG GGGGGCAAGG TGGGGGAGCC TGGAGCCCCT GTGTGGGAGG GCGAGGCGGG GGAGCCTGGA GCCCCTGTGT GGGAGGGCGA GGCGGGGGAT CCTGGAGCCC CTGTGTCGGG GGGCGAGGGA GGGGAGGTGG CCGTCGGTTG ACCTTCTGAA CATGAGTGTC AACTCCAGGA CTTGCTTCCA AGCCCTTCCC TCTGTTGGAA ATTGGGTGTG CCCTGGCTCC CAAGGGAGGC CCATGTGACT AATAAAAAAC TGTGAACCCT CGCATTTGTG TTTTAATAAA AGAATCTGGA AGATAAATAG TCTTGAAGAG AGACAAAGGA AGGAAAATTT AAATCCTTAG ATTCAAGCAG AAGAATTCCA TGTGGAAGGT TTGGGTTGTT GTTGTTGTTG TTTGGTGTGT TTTTTGTTTT TTTGTTTTTT TGTTTTTTTT TGAGATGGAG TCTCGCTGTG TTACCGGGAG CGACAGAGCC GCACGGCCGA GTCGAGTCCC AGCCAGCTAC CATCCCTCTG GAGCTTACCG GCCGGCCTTG GCTTCCCCAG GAATCCCTGG AGCTAGCGGC TGCTGAAGGC GTCGAGGTGT GGGGGCACTT GGACAGAACA GTCAGGCAGC CGGGAGCTCT GCCAGCTTTG GTGACCTTGG GTGCTTGCCT CGTGCCCCTT GGTGCCCGTC TGCTGATGTG CCCAGCCTGT GCCCGCCATG CCGCCCTCCA TCTCAGCTTT CCAGGCCGCC TACATCGGCA TCGAGGTGCT CATCGCCCTG GTCTCTGTGC CCGGGAACGT GCTGGTGATC TGGGCGGTGA AGGTGAACCA GGCGCTGCGG GATGCCACCT TCTGCTTCAT CGTGTCGCTG GCGGTGGCTG ATGTGGCCGT GGGTGCCCTG GTCATCCCCC TCGCCATCCT CATCAACATT GGGCCACAGA CCTACTTCCA CACCTGCCTC ATGGTTGCCT GTCCGGTCCT CATCCTCACC CAGAGCTCCA TCCTGGCCCT GCTGGCAATT GCTGTGGACC GCTACCTCCG GGTCAAGATC CCTCTCCGGT ACAAGATGGT GGTGACCCCC CGGAGGGCGG CGGTGGCCAT AGCCGGCTGC TGGATCCTCT CCTTCGTGGT GGGACTGACC CCTATGTTTG GCTGGAACAA TCTGAGTGCG GTGGAGCGGG CCTGGGCAGC CAACGGCAGC ATGGGGGAGC CCGTGATCAA GTGCGAGTTC GAGAAGGTCA TCAGCATGGA GTACATGGTC TACTTCAACT TCTTTGTGTG GGTGCTGCCC CCGCTTCTCC TCATGGTCCT CATCTACCTG GAGGTCTTCT ACCTAATCCG CAAGCAGCTC AACAAGAAGG TGTCGGCCTC CTCCGGCGAC CCGCAGAAGT ACTATGGGAA GGAGCTGAAG ATCGCCAAGT CGCTGGCCCT CATCCTCTTC CTCTTTGCCC TCAGCTGGCT GCCTTTGCAC ATCCTCAACT GCATCACCCT CTTCTGCCCG TCCTGCCACA AGCCCAGCAT CCTTACCTAC ATTGCCATCT TCCTCACGCA CGGCAACTCG GCCATGAACC CCATTGTCTA TGCCTTCCGC ATCCAGAAGT TCCGCGTCAC CTTCCTTAAG ATTTGGAATG ACCATTTCCG CTGCCAGCCT GCACCTCCCA TTGACGAGGA TCTCCCAGAA GAGAGGCCTG ATGACTAGAC CCCGCCTTCC GCTCCCACCG CCCACATCCA GTGGGGTCTC AGTCCAGTCC TCACATGCCC GCTGTCCCAG GGGTCTCCCT GAGCCTGCCC CAGCTGGGCT GTTGGCTGGG GGCATGGGGG AGGCTCTGAA GAGATACCCA CAGAGTGTGG TCCCTCCACT AGGAGTTAAC TACCCTACAC CTCTGGGCCC TGCAGGAGGC CTGGGAGGGC AAGGGTCCTA CGGAGGGACC AGGTGTCTAG AGGCAACAGT GTTCTGAGCC CCCACCTGCC TGACCATCCC ATGAGCAGTC CAGAGCTTCA GGGCTGGGCA GGTCCTGGGG AGGCTGAGAC TGCAGAGGAG CCACCTGGGC TGGGAGAAGG TGCTTGGGCT TCTGCGGTGA GGCAGGGGAG TCTGCTTGTC TTAGATGTTG GTGGTGCAGC CCCAGGACCA AGCTTAAGGA GAGGAGAGCA TCTGCTCTGA GACGGATGGA AGGAGAGAGG TTGAGGATGC ACTGGCCTGT TCTGTAGGAG AGACTGGCCA GA CCCAGCCCCG AGGCTCAGAA GCGGCAGGCG GAGGCGCGGT CCGGGCGCTA TGGCCATGCC CGGCGGGTCT CACGCGGCTG CCCCTCGCCC GGCGCGCCTT CGGTAGGGGG CGCCCGGGGC CCAGCTGGCC CGGCCATGCT GCTGGAGACA CAGGACGCGC TGTACGTGGC GCTGGAGCTG GTCATCGCCG CGCTTTCGGT GGCGGGCAAC GTGCTGGTGT GCGCCGCGGT GGGCACGGCG AACACTCTGC AGACGCCCAC CAACTACTTC CTGGTGTCCC TGGCTGCGGC CGACGTGGCC GTGGGGCTCT TCGCCATCCC CTTTGCCATC ACCATCAGCC TGGGCTTCTG CACTGACTTC TACGGCTGCC TCTTCCTCGC CTGCTTCGTG CTGGTGCTCA CGCAGAGCTC CATCTTCAGC CTTCTGGCCG TGGCAGTCGA CAGATACCTG GCCATCTGTG TCCCGCTCAG GTATAAAAGT TTGGTCACGG GGACCCGAGC AAGAGGGGTC ATTGCTGTCC TCTGGGTCCT TGCCTTTGGC ATCGGATTGA CTCCATTCCT GGGGTGGAAC AGTAAAGACA GTGCCACCAA CAACTGCACA GAACCCTGGG ATGGAACCAC GAATGAAAGC TGCTGCCTTG TGAAGTGTCT CTTTGAGAAT GTGGTCCCCA TGAGCTACAT GGTATATTTC AATTTCTTTG GGTGTGTTCT GCCCCCACTG CTTATAATGC TGGTGATCTA CATTAAGATC TTCCTGGTGG CCTGCAGGCA GCTTCAGCGC ACTGAGCTGA TGGACCACTC GAGGACCACC CTCCAGCGGG AGATCCATGC AGCCAAGTCA CTGGCCATGA TTGTGGGGAT TTTTGCCCTG TGCTGGTTAC CTGTGCATGC TGTTAACTGT GTCACTCTTT TCCAGCCAGC TCAGGGTAAA AATAAGCCCA AGTGGGCAAT GAATATGGCC ATTCTTCTGT CACATGCCAA TTCAGTTGTC AATCCCATTG TCTATGCTTA CCGGAACCGA GACTTCCGCT ACACTTTTCA CAAAATTATC TCCAGGTATC TTCTCTGCCA AGCAGATGTC AAGAGTGGGA ATGGTCAGGC TGGGGTACAG CCTGCTCTCG GTGTGGGCCT ATGATCTAGG CTCTCGCCTC TTCCAGGAGA AGATACAAAT CCACAAGAAA CAAAGAGGAC ACGGCTGGTT TTCATTGTGA AAGATAGCTA CACCTCACAA GGAAATGGAC TGCCTCTCTT GAGCACTTCC CTGGAGCTAC CACGTATCTA GCTAATATGT ATGTGTCAGT AGTAGCACCA AGGATTGACA AATATATTTA TGATCTATTC AGCTGCTTTT ACTGTGTGGA TTATGCCAAC AGCTTGAATG GATTCTAACA GACTCTTTTG TTTTTAAAAG TCTGCCTTGT TTATGGTGGA AAATTACTGA AACTATTTTA CTGTGAAACA GTGTGAACTA TTATAATGCA AATACTTTTT AACTTAGAGG CAATGGAAAA ATAAAAGTTG ACTGTACTAA AAATGTATAC TTGTTGCCAG GAAGGTGACC TCAAAAATTA AAAGTATAAT TATTCGGCCG GGCATGGTGG CTCACACCTG TAATTCCAGC ACTTTGGGAG GCCAAGGCAG GCGGATCACG AGGTCAGGAG TTCAAAACCA GCCTGTCCAA TATAGTG GGGCAATTTG TTAGTTATCC GCCGCCACCA AGACGCGGCA CGGCGCCTGG ACCGGAGGGG CCCCGCGCGG GCGCGAACTT TGGGCTCGGG CGAGTGGGTG GTGCTCCGCC CAGCCCGAGA CGGGCGGGCG CGCGGGCCAA TGGGTGCCGC CTCTTGGCCG CGGGGGGCCC CGACCCGTGG GTCCCGGCCA CCAGCGCCCC AGCCCCGAGG CTCAGAAGCG GCAGGCGGAG GCGCGGTCCG GGCGCTATGG CCATGCCCGG CGGGTCTCAC GCGGCTGCCC CTCGCCCGGC GCGCCTTCGG TAGGGGGCGC CCGGGGCCCA GCTGGCCCGG EPI-109 20

CCATGCTGCT GGAGACACAG GACGCGCTGT ACGTGGCGCT GGAGCTGGTC ATCGCCGCGC TTTCGGTGGC GGGCAACGTG CTGGTGTGCG CCGCGGTGGG CACGGCGAAC ACTCTGCAGA CGCCCACCAA CTACTTCCTG GTGTCCCTGG CTGCGGCCGA CGTGGCCGTG GGGCTCTTCG CCATCCCCTT TGCCATCACC ATCAGCCTGG GCTTCTGCAC TGACTTCTAC GGCTGCCTCT TCCTCGCCTG CTTCGTGCTG GTGCTCACGC AGAGCTCCAT CTTCAGCCTT CTGGCCGTGG CAGTCGACAG ATACCTGGCC ATCTGTGTCC CGCTCAGGTA TAAAAGTTTG GTCACGGGGA CCCGAGCAAG AGGGGTCATT GCTGTCCTCT GGGTCCTTGC CTTTGGCATC GGATTGACTC CATTCCTGGG GTGGAACAGT AAAGACAGTG CCACCAACAA CTGCACAGAA CCCTGGGATG GAACCACGAA TGAAAGCTGC TGCCTTGTGA AGTGTCTCTT TGAGAATGTG GTCCCCATGA GCTACATGGT ATATTTCAAT TTCTTTGGGT GTGTTCTGCC CCCACTGCTT ATAATGCTGG TGATCTACAT TAAGATCTTC CTGGTGGCCT GCAGGCAGCT TCAGCGCACT GAGCTGATGG ACCACTCGAG GACCACCCTC CAGCGGGAGA TCCATGCAGC CAAGTCACTG GCCATGATTG TGGGGATTTT TGCCCTGTGC TGGTTACCTG TGCATGCTGT TAACTGTGTC ACTCTTTTCC AGCCAGCTCA GGGTAAAAAT AAGCCCAAGT GGGCAATGAA TATGGCCATT CTTCTGTCAC ATGCCAATTC AGTTGTCAAT CCCATTGTCT ATGCTTACCG GAACCGAGAC TTCCGCTACA CTTTTCACAA AATTATCTCC AGGTATCTTC TCTGCCAAGC AGATGTCAAG AGTGGGAATG GTCAGGCTGG GGTACAGCCT GCTCTCGGTG TGGGCCTATG ATCTAGGCTC TCGCCTCTTC CAGGAGAAGA TACAAATCCA CAAGAAACAA AGAGGACACG GCTGGTTTTC ATTGTGAAAG ATAGCTACAC CTCACAAGGA AATGGACTGC CTCTCTTGAG CACTTCCCTG GAGCTACCAC GTATCTAGCT AATATGTATG TGTCAGTAGT AGGCTCCAAG GATTGACAAA TATATTTATG ATCTATTCAG CTGCTTTTAC TGTGTGGATT ATGCCAACAG CTTGAATGGA TTCTAACAGA CTCTTTTGTT TTTAAAAGTC TGCCTTGTTT ATGGTGGAAA ATTACTGAAA CTATTTTACT GTGAAACAGT GTGAACTATT ATAATGCAAA TACTTTTTAA CTTAGAGGCA ATGGAAAAAT AAAAGTTGAC TGTACTAAAA ATG GAATTCCCAG ATGGGCAGAG GTGGCTGGGC TGGTGACCCT AAGTGTGTCT CCTGCCTTTA TTCTCTCTAG TGGGTTATTC TTTCATGTGG TATCTTGCCT ACAGCATGCT GTGTTTGGAC ACAAACCCCT TTCCTTGGTT TCTCTGACCC AGCTGAGATG GACTGATTCC AAAAGAACTC ACCTATGTAC TGGGGTAGGG GAGGGAGGGT TTTTTGCAGT ATTTAACTAA GGTTCAAAGA GTGCTATATA GTGAGAAAGG CTTCTTTTTT TTTTTTTTTT TTTTTTGGCA GAGTGCTGCC TCCTAGAAAT TTCTCTTGGT AACTTCCTTC TCTGAAGCAC AGATAAAGAA AACAATTACA GTAGAAACAT TTATGAGGGA CACATTGGAG GCCGATGAAG CTTTTCAAGT TCCAGCAGTG CAGGGATGTG GGCAGAACTG ACATTGGAAA ATACTAGAAT GATGGAAATT CAGTTGGAGA GGACTGCCCT TTTTAATGTC TGGGGAGTCT GCTCAGGGAG AAATGACAAG TCTGGCGGGG ACAAGTATGG GATTTGGTAA GACTTGGATC AACTTGGGAT ACAGGGTGGG GGTCGGGAGT GGAATCAATG AATGATGCCA GAGCAGATCA ACTAACAAGA GGACCCTGAT GAGCCCCAGG CAGAGGCGTC TCCCTTATGC CCCACTCTGA AGTGTTTGTT AGTAAACACC AGAACGCCAT TGTTGTTACT GCTGAATTTT ATTTTGGGCT GTACATATTT AGATGCTTAA GGTAAAAATG ATAAAGCCCT CAAGCCACTG TGTGGGTTTG GGTCCAAGTG TTCCTTCTTG CTGCCTCTCT AACACGCCTG GTTAAAATAA TCCCTTTGGA TGGTGCTGAG AAGCACCTGA ACCAAGTGGG TCCCCAAATA ACAATGGCGT GCAAGTGTCT GGTTCCCAGA AGTTGGTGAC TAGGTAAGCA GCTTCAGGGA GAGGGGGCTG ATTCCCAGAC AGTCGCCTGT TCCTGCGGGG ATGGGGCTGA GGCTTGGGGA ATGTGGGCAG GAGGATATGC CATTTGATTC TGTTGCACAC GTTCTTTTCC CTTCTTTCTG TATGTCTGGT CATTCTGCTA TTCTGTCGTT CCTCACATAG GTTGGACATT GGCCGGCTGC CAGCATAAGT GCCAGTGTGA TTTTGCTAGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG TTTTTGCCCT TCTGAGCAGG GAATCTTTGC TTATCCCTTT GACCAAGGAT CTTTGCTGCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGGTTAGGA GGCTGCCACC AAAGTCTCTT TTTTGTTCCT CTGCTTCTCC CGTTTGCCTC CTTATCATGA GATCTTTTTG CTAAGCTGGC AGAAAGATTG CATAGTCAGT GCTTCCAGCT CTGCTCCCAC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC GAGCCTTCTC TATGCCACTC ATGGCTCCTC TTCTGCTCTT TCCATCTTTT TGCTGAGAGT TCTGAGCTCT GTACTTCCTC TTGGCCCATC TCACTTCCTG AAACACCCCT GAAGAGGGTT GCTTATCTTG ATGGAACTCA AAAAGCCAAA AAGCTGCAGG CAGAGGCGTT GAGGACATCT GTTTGGGGAA CTAAGAGCAG CAGCACTTTC AGATTCAGTC CATATAGAGC TGTCCTACAG CATTCTGGAA ACTTGAGGAT GTGCGGTGCA TAAAGGGGCT GGAAGTGACC CACCTGTGAT GAGCCCTTTC TAAGGAGAAG GGTTTCCAAG AGATCACCCC ACCAGAAAAG GGTAGGAATG AGCAAGTTGG GAATTTTAGA CTGTCACTGC ACATGGACCT CTGGGAAGAC GTCTGGCGAG AGCTAGGCCC ACTGGCCCTA CAGACGGATC TTGCTGGCTC ACCTGTCCCT GTGGAGGTTC CCCTGGGAAG GCAAGATGCC CAACAACAGC ACTGCTCTGT CATTGGCCAA TGTTACCTAC ATCACCATGG AAATTTTCAT TGGACTCTGC GCCATAGTGG GCAACGTGCT GGTCATCTGC GTGGTCAAGC TGAACCCCAG CCTGCAGACC ACCACCTTCT ATTTCATTGT CTCTCTAGCC CTGGCTGACA TTGCTGTTGG GGTGCTGGTC ATGCCTTTGG CCATTGTTGT CAGCCTGGGC ATCACAATCC ACTTCTACAG CTGCCTTTTT ATGACTTGCC TACTGCTTAT CTTTACCCAC GCCTCCATCA TGTCCTTGCT GGCCATCGCT GTGGACCGAT ACTTGCGGGT CAAGCTTACC GTCAGGTAGC CTGCGGCGTG GGGTGGGCAG CAATTGAGGC AGCTGGGAAA TGAGGCTACA AAGCCAGAGCS CTGCTGAATT TTATTTTGGA CTGTACATAT TTAGATGCTT AAGGTAAAAA TGATAAAGCC CTCAAGCCAC TGTGTGGGTT GGGTCCAAGT GTTCCTTGCT GCTGCCTCTC TAACACGCCT GGTTAAAATA ATCCCTTTGG ATGGTGCTGA GAAGCACCTG AACCAAGTGG GTCCCCAAAT AACTATGGCG TGCAAGTGTC TGGTTCCCAG AAGTTGGTGA CTAGGTAAGC GACTCAGGGA GAGGGGCTGA TTCCCAGACA GTCGCCTGTT CCTGCTGGGA TGGGGCTGAG GCTTGGGGAA TGTGGGCAGG AGGATATGCC ATTTGATTCT GTTGCACACG TTCTTTTCCC TTCTTTCTGT ATGTCTGGTC ATTCTGCTAT TCTGTCGTTC CTCACATAGG TTGGACATTG GCCGGCTGCC AGCATAAGTG CCAGTGTGAT TTTGCTAGGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG TTTTTGCCCT TCTGAGCAGG GAATCTTTGC TTATCCCTTT GACCAAGGAT CTTTGCTCCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGGTTAGGA GGCTGCCACC AAAGTCTCTT TTTTGTTCCT CTGCTTCTCC CGTTTGCCTC CTTATCATGA GATCTTTTTG CTAAGCTGGC AGAAAGATTG CATAATCAGT GCTTCCAGCT CCGCTCCCAC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC GAGCCTTCTC EPI-109 21

TATGCCACTC ATGGCTCCTC TTCTGCTCTT TCCATCTTTT TGCTGAGAGT TACTGAGCTC TGTACTTCCT CTTGGCCCAT CTCACTTCCT GAAACACCCC TGAAGAGGGT TGCTTATCTT GATGGAACTC AAAAAGCCAA AAAGCTGCAG GCAGAGGCGT TGAGGACATC TGTTTGGGGA ACTAAGAGCA GCAGCACTTT CAGATTCAGT CCATATAGAG CTGTCCTACA GCATTCTGGA AACTTGAGGA TGTGCGGTGC ATAAAGGGGC TGGAAGTGAC CCACCTGTGA TGAGCCCTTT CTAAGGAGAA GGGTTTCCAA GAGATCACCC CACCAGAAAA GGGTAGGAAT GAGCAAGTTG GGAATTTTAG ACTGTCACTG CACATGGACC TCTGGGAAGA CGTCTGGCGA GAGCTAGGCC CACTGGCCCT ACAGACGGAT CTTGCTGGCT CACCTGTCCC TGTGGAGGTT CCCCTGGGAA GGCAAGATGC CCAACAACAG CACTGCTCTG CGAATTCGGG GGACATCTGT TTGGGGAACT AAGAGCAGCA GCACTTTCAG ATTCAGTCCA TATAGAGCTG TCCTACAGCA TTCTGGAAAC TTGAGGATGT GCGGTGCATA AACGGGCTGG AAGTGACCCA CCTGTGATGA GCCCTTTCTA AGGAGAAGGG TTTCCAAGAG ATCACCCCAC CAGAAAAGGG TAGGAATGAG CAAGTTGGGA ATTTTAGACT GTCACTGCAC ATGGACCTCT GGGAAGACGT CTGGCGAGAG CTAGGCCCAC TGGCCCTACA GACGGATCTT GCTGGCTCAC CTGTCCCTGT GGAGGTTCCC CTGGGAAGGC AAGATGCCCA ACAACAGCAC TGCTCTGTCA TTGGCCAATG TTACCTACAT CACCATGGAA ATTTTCATTG GACTCTGCGC CATAGTGGGC AACGTGCTGG TCATCTGCGT GGTCAAGCTG AACCCCAGCC TGCAGACCAC CACCTTCTAT TTCATTGTCT CTCTAGCCCT GGCTGACATT GCTGTTGGGG TGCTGGTCAT GCCTTTGGCC ATTGTTGTCA GCCTGGGCAT CACAATCCAC TTCTACAGCT GCCTTTTTAT GACTTGCCTA CTGCTTATCT TTACCCACGC CTCCATCATG TCCTTGCTGG CCATCGCTGT GGACCGATAC TTGCGGGTCA AGCTTACCGT CAGATACAAG AGGGTCACCA CTCACAGAAG AATATGGCTG GCCCTGGGCC TTTGCTGGCT GGTGTCATTC CTGGTGGGAT TGACCCCCAT GTTTGGCTGG AACATGAAAC TGACCTCAGA GTACCACAGA AATGTCACCT TCCTTTCATG CCAATTTGTT TCCGTCATGA GGATGGACTA CATGGTATAC TTCAGCTTCC TCACCTGGAT TTTCATCCCC CTGGTTGTCA TGTGCGCCAT CTATCTTGAC ATCTTTTACA TCATTCGGAA CAAACTCAGT CTGAACTTAT CTAACTCCAA AGAGACAGGT GCATTTTATG GACGGGAGTT CAAGACGGCT AAGTCCTTGT TTCTGGTTCT TTTCTTGTTT GCTCTGTCAT GGCTGCCTTT ATCTCTCATC AACTGCATCA TCTACTTTAA TGGTGAGGTA CCACAGCTTG TGCTGTACAT GGGCATCCTG CTGTCCCATG CCAACTCCAT GATGAACCCT ATCGTCTATG CCTATAAAAT AAAGAAGTTC AAGGAAACCT ACCTTTTGAT CCTCAAAGCC TGTGTGGTCT GCCATCCCTC TGATTCTTTG GACACAAGCA TTGAGAAGAA TTCTGAGTAG TTATCCATCA GAGATGACTC TGTCTCATTG ACCTTCAGAT TCCCCATCAA CAAACACTTG AGGGCCTGTA TGCCTGGGCC AAGGGATTTT TACATCCTTG ATTACTTCCA CTGAGGTGGG AGCATCTCCA GTGCTCCCCA ATTATATCTC CCCCACTCCA CTACTCTCTT CCTCCACTTC ATTTTTCCTT TGTCCTTTCT CTCTAATTCA GTGTTTTGGA GGCCTGACTT GGGGACAACG TATTATTGAT ATTATTGTCT GTTTTCCTTC TTCCCAATAG AAGAATAAGT CATGGAGCCT GAAGGGTGCC TAGTTGACTT ACTGACAAAA GGCTCTAGTT GGGCTGAACA TGTGTGTGGT GGTGACTCAT TTCCATGCCA TTGTGGAATT GAGCAGAGAA CCTGCTCTCG GAGGATGCCT AGGAGATGTT GGGAACAGAA GAAATAAACT GAGTTTAAGG GGGACTTAAA CTGCTGAATT C AAATGATAGA CCGTCAATAA TTTGTTAAAT GCTTTTTAAA ATGAATGCTT TAAGCCGGGT GCAGTGCCTC ACATCTGTAA TCCCAGCACT TTGGAGCCGA GCGGGTGGAT TGTGTGAGGT CAGGAGTTCG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCTCTACC AAAAATACAA AAATTAGCCA GGCATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG GAGAATCGCT TGAACCCGGG AGGCAAGGTT GCAGTGAGCC AAGATTACGC CATTGTACTC CAGCCTGGGT GACAGAGAGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATTAC GCTTCAAACA CATGATCTCT CACCACTGTT GAATTTTCTT TCTATGAGCC CAGGAGGGCC TCTCAGAGAG GAAAGCTCCT AGGTCTTCCT TTCCCTCTGC AAACTCCCTG CCTTGAAGGT TCAGAAGGAC TGTGCGTGCT CGTTGCATCC TTTGCAAGTG TCCAAACCCT GATCCCAGCT GTGCTTAGGG GTTCCTGCAA ACCTTTTCCA GGTGTTAATT ACCTCCCACT TCATTTCCTG TTTACCAACT CAGCTTTTTG TTTTAGTGTG TTTGAATTCC CTGAACTGAC CGTTGTCTGA TCTCCACCTC CCAACTGAAT TAGGGGAGCT GGGCTTCTGG AAACCCAGGT GCCGGGTGTT GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACACACAC ACCCACATAC CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TTGGACATGC ATAGACCACA GCTTTCCACA CCCTTCCTAG ACAGGGGTCA CTTGGTATCC TGGAGAGAGT GTGAAGTCCT GGAATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA CAAGTCACCA CCAACCCATC TGCGCCTTGT TTACCTCCTC TGTGAGGCAA GCACAGAGCC CATGCCTGCC CCCCTGGATG GGAGTGATGT GAAACTTGAA GGGCGGTCAG AGCAAGGGTC GGGAATGGAA GGCCCTTGGG AAAAAAGGCC CTTTCAACTA GGGGCACAGA GGAGGCCCTG GGCTGAGAAC TTGACAGCAC CTTGTAATTG GTAAGCCAAG CCCGAAGGGA CTGGAAATAC TCAGATGTGT CTGTCTCCCT TATTAGGTTC AAAGTCCCTC AAGACCCTGT CTCCATCACA GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGACCCAA CCAGCCCTAT GGGGTCGCAT CCCCACCTGC CTGGAATTCT CCAAAGAACC TCCCCTTTAA CAGTTCCAGC CTTTAACAGT TCCAGTCTAA ACACATGACC TTTCTCCTCT AAATCAGCCC CCCATCTCTG CCTTTGCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC CCATCCATGT CCAATCAAGC ACTAGGCATG TCAGGTTTAC CCTCTAAACT CCTCTGGAAT CCAGTCTCTC AGTCTCCATC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCTTGCTTC CACTCTACCC CCACTGCAGT CCTGACTTCC TGAGCAGCAG CCAGGGCCTA ATCGATATTC ACACCAAGCG CCAACCTGAC TGAGATATCC TCCTGCACCA TCATCCCTCC ACCCTGTTTA GTTCTGCTCA CCCTCAGTGT TCTCATCAAT AATCCACTCC CCTCACAGGC GCGTTTGGGA CCCCATGTTC TATGCTCTCA CAGGACCTTT TGCTTGATTT TTCACTGTAC TTAGGTCAGT TTGCAGTTAT TAAGTGACTG AGCAATGTCT GGCTTCTCCA GTAGACTGTC AGCTCCTAGC CATTGTATAC CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG AGTCAGGGAC TCAGCAGTCT CCATTTCTCC GCCCTGCTGG AGAATGCGTG TATTTGGCAA TCCCCAGCCC CTGTGCCATC TAACCATCTT TTCTTCTCTG TTCAGCCCAG GTGTGGCCTC ACTCACATCC CACTCTGAGT CCAAATGTTC TCTCCCTGGA AGATATCAAT GTTTCTGTCT GTTCGTGAGG ACTCCGTGCC CACCACGGCC TCTTTCAGGT GAGTCAAAGG GATTCCTCAG TTCACTAGTT AGGGGAGGTG GGCAGACACC CTGGAGAACT CCCTGGAAAG CTCAACTCTC ATGCCCCGGA CAACAGTTGA AGGAACCATG GTGATGTTAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGTTG GAATCTTGGG AGCAGAGGGA ATGTTCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA AGGGCACATT CCTGGTTGTT ATATGTTTCT ATCTATCCCA EPI-109 22

GATGAACTTG GAAGTGAAGG GAAGAGAGTT AAACATTAAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC CTTGGAAACA AAATATCTCC AACACATGGC TGACATTTGG TGGGAGATCA GAACACCCTA AAGAGAGAAT TTAAGGGGAG GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC AGAGGATAGG GAGATCTGTT CTTGGGGACA GCATTTGCAA GAAACAAGGC TGAGGGGTCC ACTCCAACCT CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGGCCAT CTCAGCTGGG GCCACAGTGC ACTGGACCTA TAGTTTCCAA TTCCGCACTC AGCAGGCATC TTTCTGATGA TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCTTGGCT ACTGTCTTGC TGAGAAATTT ATAAGCAGCA TCTGGTGCTA TACTTTGGTC TCTAGTGAGT TAGCTCATGA AAGATGATAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GGTTTTCTGT AGCTACAGAA ATGGGGTTGA GGGTTGGACC AAGGGACTAC CCAGGGGAAG TCTTACCTTC AGAGGACTCT GGAAAGGAGG CTGCAAGTTT TCATGGGTCA AGAATTCAGA GCCCAGTAGA GACAGCTTAT CTCTGTTCCA AGATGTCTGG GGCCTTGGTT GGAAGATTCA AAGGCTAGGA AACCAGGAGC CACCAAAAGC GTAACTGGGG CCAGAGGATC CACTTTCAAG GTGGCAAGTT GGTTCCCCCC ATGTGGCTGC TTGAGTATCC TCACATGGCG GCTCACATCC TTCCAAGTAA GCAATGCAAA AGGCCAAGAA AGATGCTGCA AAGATGTTAT GACCTAGCCT CAGAAATCAC ACACCATCCC TGCCACCATT AGTAAGAAGT CCAGCCCACG TCCAGGAGAA GAGGAAGCAG ATTCCTCCTT TTGAAATGAA GAATATCAAG TAATTCGGGG GGCATATGAA AGCCACCACA CACCACAGGG ATCTTTTTAG AGCATACTTC TTATACCATC ACTGTAGTTC CTTAAGACTC AGGGGCAAAG CCTCACTTCC TTAGCACCCA GTGAAGACCA CGCTTACTCC CTCACTCAAC CTCTTGCTAC TTCCCACCTC TCCTGTCCAA CATCTAGTGT CACTTTCCAG AACATACCAA CAGCTTCCCC AGTTCTGTGC CTCTGCTCAG GCTGTTCCCC CTGCCTGGTC CACTTGTCCT CCTTCTTGTC CGGTCAAAAT GCTTCTTATC CTTCAAGACC CAGCTCTAGA GTCACCTCCA ACCCCTTACC CACCAGCCCC CTCTCCAAGT CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC CACCCTCTGG GCCACAGTTG TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG GTGTCTTCTT TGTGTTCTTG CACTCAGGGC AGAGCTCAGC ACAGAGCAGA CGCTCAAAAA ACATTTAAAG GATAGAAGCA TTGATTTGTG GGTCCCCCAG TCTGGCTCCA GGATGCCAGC CAGCTGCTCC TAGAAGCAAA CGGACTTTTC CTGGGAAATC CCAGAGGTGA TGATCAGTAA TCTCTCCCGT GACTCGTAGT TCAGCTCTTC CTCCATGAGC CTGACTATCA GTGGACCTTC CAGAAAGAGC CCCTTTTCCT TCTCTCACCC ACAGCACAGG GCACTGGGAA AATGCCCAAT GAGTCCTGCC TCTGGGTTGT GCTTTGGACT TTTCAGTGTG TCTCGCATCC ACTCTTCAAC TTGAATGTTG CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATTCAGGATG AGAGCAATAC CCTACTCCAA AGAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAATTTGC CCAAGACCAC ACAGCTAGGA GTGGAACTCA TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GGTAGAGATG AATTACAGCA ACAAGTCTAG AAAGGTGCCT GCCCTATGGT CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA GCCAGTGGGT TAAAGATGAG GTCACCAACA ACGGTGGTGT TGGAGTTTAC CACTGATAAT AAGGGTGCAA AATGTAAATT ACTAATGTTT ATTGAGCCTA GTGCAGTGCG TGGGGCATTT TGCACATTGT CTCTGATCCC TATGACAACC CTGAGAGGTA GTGGTTTTAA CTGCCATGTT ACAGGTGAGG TCATTGTGGT TCAAGGACGT TAAGTAACTT CCCCAGCGTG ACACGGCTTA TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT GGCTGCAAAG TCCCCACCCC CCTCGCCATC TGTATCCTCC AATCACTTCA GTGCTTTGCT GCATAGAAGG TAACGGAAAT CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCTC CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATT TTTCTCTTTT AATAAATTAA CTCACCCACC ACACGGCTTT GAGAGGCTCA AAGTTGACCA ACTCCCTTGG GAGGGCCCCG GTTGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC TTCAAGGAGG TCAAGGGTCC AACACTTGAG ATTGTTAGTG CTGTTGGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC CTCGAGATGA AGAACATGAG GCCCCCGTTT AGAACCAAGG ATCAGAGGGG GCTCTGTAAG ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT CGGCTTCTCC TTGTCCTGGC TGGTTGTCCT TAACCCCTGT CTCCTTCTGG ACCAGTTTTT GTCCTTCCCT TGTGACCGCT GAGGGGTAAC AGCCTCTTTC CACTTTCTTT CAGCGCCGAC ATGCTCAATG TCACCTTGCA AGGGCCCACT CTTAACGGGA CCTTTGCCCA GAGCAAATGC CCCCAAGTGG AGTGGCTGGG CTGGCTCAAC ACCATCCAGC CCCCCTTCCT CTGGGTGCTG TTCGTGCTGG CCACCCTAGA GAACATCTTT GTCCTCAGCG TCTTCTGCCT GCACAAGAGC AGCTGCACGG TGGCAGAGAT CTACCTGGGG AACCTGGCCG CAGCAGACCT GATCCTGGCC TGCGGGCTGC CCTTCTGGGC CATCACCATC TCCAACAACT TCGACTGGCT CTTTGGGGAG ACGCTCTGCC GCGTGGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG CATCTGTTTC CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG ATGCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTGGGGGTG TACGCTGCTC CTGAGCTCAC CCATGCTGGT GTTCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC GTCACCGCTT GTGTCATCAG CTACCCATCC CTCATCTGGG AAGTGTTCAC CAACATGCTC CTGAATGTCG TGGGCTTCCT GCTGCCCCTG AGTGTCATCA CCTTCTGCAC GATGCAGATC ATGCAGGTGC TGCGGAACAA CGAGATGCAG AAGTTCAAGG AGATCCAGAC GGAGAGGAGG GCCACGGTGC TAGTCCTGGT TGTGCTGCTG CTATTCATCA TCTGCTGGCT GCCCTTCCAG ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGGCATCC TCTCCAGCTG CCAGGACGAG CGCATCATCG ATGTAATCAC ACAGATCGCC TCCTTCATGG CCTACAGCAA CAGCTGCCTC AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTTCCGAA AGAAGTCTTG GGAGGTGTAC CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA TTCAGATGGA GAACTCCATG GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTGCA GGACTGGGCA GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA ATTTGTGTAA GGATTGAGGG ACAGTTGCTT TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG AAATGAGTTG ATGTCTCCGG TAAAACACCG GAGACTAATT CCTGCCCTGC CCAATTTTGC AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA ACAGCATTAC TGTTCTTATT TGCTGCCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGTG GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA CTGAGCTTCC CTCCCGTGTG TTCTCCGTCC CTGCCCCAGC AAGACAACTT AGATCTCCAG GAGAACTGCC ATCCAGCTTT GGTGCAATGG CTGAGTGCAC AAGTGAGTTG TTGCCCTGGG TTTCTTTAAT CTATTCAGCT AGAACTTTGA AGGACAATTT CTTGCATTAA TAAAGGTTAA GCCCTGAGGG GTCCCTGATA ACAACCTGGA GACCAGGATT TTATGGCTCC CCTCACTGAT GGACAAGGAG GTCTGTGCCA AAGAAGAATC CAATAAGCAC ATATTGAGCA CTTGCTGTAT ATGCAGTATT GAGCACTGTA GGCAAGAGGG AAGAAAGAGA AGGAGCCATC EPI-109 23

TCCATCTTGA AGGAACTCAA AGACTCAAGT GGGAACGACT GGGCACTGCC ACCACCAGAA AGCTGTTCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA TATGGACAGC AGAAGGGGGA GCCAGGTTCC AGCTCACCAA TACTATTGCA CACCACCTGT CCTGCCTC GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGCCC ATGCCGCTTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTTTCCCTG TGGTCGTGGG GAGTT GAGCTCTTCA ATATTTTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA CACACCTTTT CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA CTGGCAAGTC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGTTTCC CTGTCTCCAT GATGATGGGA TCAGGCTTGA TTGCTGGTTT GTAGGCTTGT TATGAATCAA GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTTCC CCAGATCCAC TGGGCCCACT CTTATCTGTT CTCTTCTGAA GGAAGGGTTT TAAGGCTTCA AAAAAAAATG TTTTGAAAGT CCCTGCCCTT TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAAAC TGAGAAAGCC AGCCTGAGCC TTGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGCC ACTGTCGCCC TTGGGAGCCG TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTTTA CACCTTCCGC GTAAACGCCC ACTGTTTACA TCCAAAACTC AGACACAAAA TAACCACCTC AAGAAGATAA ATAATGATAA GAAATAAATG TTACGCGAGG CAAATTTATT CACATGGGGC TTCCCAGGCC ACTTTGTGGT CAGCCGGGAG GGACGTTTTT GCCGTCCCAC GACTCCAACG GGCAGCCGGG CCTACGCAAA CATGGAAATC TTCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCTT CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCTTCAAAG ATGAGCTGTT CCCGCCGCCA CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGAGAAG GTGGGTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AGTTGGGAAA AGTTCCCTTC CTTCCGGAGG GAGG CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT GCCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAGCTTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT CTTTAATCTA TTCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA TTGAGCACTT GCTGTATATG CAGTATTGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCTTGAAGG AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTT TTATGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC GGTGTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTT CCACCTGTCA TTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCATTTGGAG AGAAGGCCAT GTCTTCAAAG TCTGATTTGT GATGAGGCAG AGGAAGATAT TTCTAATCGG TCTTGCCCAG AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG GCCTGCTCAG GGACTGTTCC TGTCTCAGCA ACCAAGGGAT TGTTCCTGTC AATCAATGGT TTATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGTGT TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT AAATGAATAT TTATTAGCTG GTTGGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA ACCTAGAAGG GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGTTA GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATTTACAT GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAAT TTTAAAGCAA AAGCGTGAAA AAAAAGATTC CCTCCTTACC CCCAACCCAC TCTTTTTTCC CACCACCCAC TCTCCTCTGC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATTTAGTATT AGTATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC TGTGTTTTGT CACACAGGGC AGTCATTCAG CACCAGAGCA CGTGATGGTC TGAGACTCTC TTAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC TGTCCTGTGA AAGACTCAAT GAGCTGTTAT GTTGTAAACA GGAAGCATTT CACATCCAAA CGAGAAAATC ATGTAAACAT GTGTCTTTTC TGTAGAGCAT AATAAATGGA TGAGGTTTTT GCAAAAAAAA AAAAAAAAA AAATGATAGA CCGTCAATAA TTTGTTAAAT GCTTTTTAAA ATGAATGCTT TAAGCCGGGT GCAGTGCCTC ACATCTGTAA TCCCAGCACT TTGGAGCCGA GCGGGTGGAT TGTGTGAGGT CAGGAGTTCG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCTCTACC AAAAATACAA AAATTAGCCA GGCATGGTGG EPI-109 24

CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG GAGAATCGCT TGAACCCGGG AGGCAAGGTT GCAGTGAGCC AAGATTACGC CATTGTACTC CAGCCTGGGT GACAGAGAGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATTAC GCTTCAAACA CATGATCTCT CACCACTGTT GAATTTTCTT TCTATGAGCC CAGGAGGGCC TCTCAGAGAG GAAAGCTCCT AGGTCTTCCT TTCCCTCTGC AAACTCCCTG CCTTGAAGGT TCAGAAGGAC TGTGCGTGCT CGTTGCATCC TTTGCAAGTG TCCAAACCCT GATCCCAGCT GTGCTTAGGG GTTCCTGCAA ACCTTTTCCA GGTGTTAATT ACCTCCCACT TCATTTCCTG TTTACCAACT CAGCTTTTTG TTTTAGTGTG TTTGAATTCC CTGAACTGAC CGTTGTCTGA TCTCCACCTC CCAACTGAAT TAGGGGAGCT GGGCTTCTGG AAACCCAGGT GCCGGGTGTT GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACACACAC ACCCACATAC CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TTGGACATGC ATAGACCACA GCTTTCCACA CCCTTCCTAG ACAGGGGTCA CTTGGTATCC TGGAGAGAGT GTGAAGTCCT GGAATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA CAAGTCACCA CCAACCCATC TGCGCCTTGT TTACCTCCTC TGTGAGGCAA GCACAGAGCC CATGCCTGCC CCCCTGGATG GGAGTGATGT GAAACTTGAA GGGCGGTCAG AGCAAGGGTC GGGAATGGAA GGCCCTTGGG AAAAAAGGCC CTTTCAACTA GGGGCACAGA GGAGGCCCTG GGCTGAGAAC TTGACAGCAC CTTGTAATTG GTAAGCCAAG CCCGAAGGGA CTGGAAATAC TCAGATGTGT CTGTCTCCCT TATTAGGTTC AAAGTCCCTC AAGACCCTGT CTCCATCACA GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGACCCAA CCAGCCCTAT GGGGTCGCAT CCCCACCTGC CTGGAATTCT CCAAAGAACC TCCCCTTTAA CAGTTCCAGC CTTTAACAGT TCCAGTCTAA ACACATGACC TTTCTCCTCT AAATCAGCCC CCCATCTCTG CCTTTGCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC CCATCCATGT CCAATCAAGC ACTAGGCATG TCAGGTTTAC CCTCTAAACT CCTCTGGAAT CCAGTCTCTC AGTCTCCATC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCTTGCTTC CACTCTACCC CCACTGCAGT CCTGACTTCC TGAGCAGCAG CCAGGGCCTA ATCGATATTC ACACCAAGCG CCAACCTGAC TGAGATATCC TCCTGCACCA TCATCCCTCC ACCCTGTTTA GTTCTGCTCA CCCTCAGTGT TCTCATCAAT AATCCACTCC CCTCACAGGC GCGTTTGGGA CCCCATGTTC TATGCTCTCA CAGGACCTTT TGCTTGATTT TTCACTGTAC TTAGGTCAGT TTGCAGTTAT TAAGTGACTG AGCAATGTCT GGCTTCTCCA GTAGACTGTC AGCTCCTAGC CATTGTATAC CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG AGTCAGGGAC TCAGCAGTCT CCATTTCTCC GCCCTGCTGG AGAATGCGTG TATTTGGCAA TCCCCAGCCC CTGTGCCATC TAACCATCTT TTCTTCTCTG TTCAGCCCAG GTGTGGCCTC ACTCACATCC CACTCTGAGT CCAAATGTTC TCTCCCTGGA AGATATCAAT GTTTCTGTCT GTTCGTGAGG ACTCCGTGCC CACCACGGCC TCTTTCAGGT GAGTCAAAGG GATTCCTCAG TTCACTAGTT AGGGGAGGTG GGCAGACACC CTGGAGAACT CCCTGGAAAG CTCAACTCTC ATGCCCCGGA CAACAGTTGA AGGAACCATG GTGATGTTAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGTTG GAATCTTGGG AGCAGAGGGA ATGTTCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA AGGGCACATT CCTGGTTGTT ATATGTTTCT ATCTATCCCA GATGAACTTG GAAGTGAAGG GAAGAGAGTT AAACATTAAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC CTTGGAAACA AAATATCTCC AACACATGGC TGACATTTGG TGGGAGATCA GAACACCCTA AAGAGAGAAT TTAAGGGGAG GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC AGAGGATAGG GAGATCTGTT CTTGGGGACA GCATTTGCAA GAAACAAGGC TGAGGGGTCC ACTCCAACCT CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGGCCAT CTCAGCTGGG GCCACAGTGC ACTGGACCTA TAGTTTCCAA TTCCGCACTC AGCAGGCATC TTTCTGATGA TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCTTGGCT ACTGTCTTGC TGAGAAATTT ATAAGCAGCA TCTGGTGCTA TACTTTGGTC TCTAGTGAGT TAGCTCATGA AAGATGATAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GGTTTTCTGT AGCTACAGAA ATGGGGTTGA GGGTTGGACC AAGGGACTAC CCAGGGGAAG TCTTACCTTC AGAGGACTCT GGAAAGGAGG CTGCAAGTTT TCATGGGTCA AGAATTCAGA GCCCAGTAGA GACAGCTTAT CTCTGTTCCA AGATGTCTGG GGCCTTGGTT GGAAGATTCA AAGGCTAGGA AACCAGGAGC CACCAAAAGC GTAACTGGGG CCAGAGGATC CACTTTCAAG GTGGCAAGTT GGTTCCCCCC ATGTGGCTGC TTGAGTATCC TCACATGGCG GCTCACATCC TTCCAAGTAA GCAATGCAAA AGGCCAAGAA AGATGCTGCA AAGATGTTAT GACCTAGCCT CAGAAATCAC ACACCATCCC TGCCACCATT AGTAAGAAGT CCAGCCCACG TCCAGGAGAA GAGGAAGCAG ATTCCTCCTT TTGAAATGAA GAATATCAAG TAATTCGGGG GGCATATGAA AGCCACCACA CACCACAGGG ATCTTTTTAG AGCATACTTC TTATACCATC ACTGTAGTTC CTTAAGACTC AGGGGCAAAG CCTCACTTCC TTAGCACCCA GTGAAGACCA CGCTTACTCC CTCACTCAAC CTCTTGCTAC TTCCCACCTC TCCTGTCCAA CATCTAGTGT CACTTTCCAG AACATACCAA CAGCTTCCCC AGTTCTGTGC CTCTGCTCAG GCTGTTCCCC CTGCCTGGTC CACTTGTCCT CCTTCTTGTC CGGTCAAAAT GCTTCTTATC CTTCAAGACC CAGCTCTAGA GTCACCTCCA ACCCCTTACC CACCAGCCCC CTCTCCAAGT CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC CACCCTCTGG GCCACAGTTG TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG GTGTCTTCTT TGTGTTCTTG CACTCAGGGC AGAGCTCAGC ACAGAGCAGA CGCTCAAAAA ACATTTAAAG GATAGAAGCA TTGATTTGTG GGTCCCCCAG TCTGGCTCCA GGATGCCAGC CAGCTGCTCC TAGAAGCAAA CGGACTTTTC CTGGGAAATC CCAGAGGTGA TGATCAGTAA TCTCTCCCGT GACTCGTAGT TCAGCTCTTC CTCCATGAGC CTGACTATCA GTGGACCTTC CAGAAAGAGC CCCTTTTCCT TCTCTCACCC ACAGCACAGG GCACTGGGAA AATGCCCAAT GAGTCCTGCC TCTGGGTTGT GCTTTGGACT TTTCAGTGTG TCTCGCATCC ACTCTTCAAC TTGAATGTTG CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATTCAGGATG AGAGCAATAC CCTACTCCAA AGAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAATTTGC CCAAGACCAC ACAGCTAGGA GTGGAACTCA TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GGTAGAGATG AATTACAGCA ACAAGTCTAG AAAGGTGCCT GCCCTATGGT CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA GCCAGTGGGT TAAAGATGAG GTCACCAACA ACGGTGGTGT TGGAGTTTAC CACTGATAAT AAGGGTGCAA AATGTAAATT ACTAATGTTT ATTGAGCCTA GTGCAGTGCG TGGGGCATTT TGCACATTGT CTCTGATCCC TATGACAACC CTGAGAGGTA GTGGTTTTAA CTGCCATGTT ACAGGTGAGG TCATTGTGGT TCAAGGACGT TAAGTAACTT CCCCAGCGTG ACACGGCTTA TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT GGCTGCAAAG TCCCCACCCC CCTCGCCATC TGTATCCTCC AATCACTTCA GTGCTTTGCT GCATAGAAGG TAACGGAAAT CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCTC CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATT TTTCTCTTTT AATAAATTAA CTCACCCACC ACACGGCTTT GAGAGGCTCA AAGTTGACCA ACTCCCTTGG GAGGGCCCCG GTTGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC TTCAAGGAGG TCAAGGGTCC AACACTTGAG ATTGTTAGTG CTGTTGGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC CTCGAGATGA AGAACATGAG GCCCCCGTTT AGAACCAAGG ATCAGAGGGG GCTCTGTAAG ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT CGGCTTCTCC TTGTCCTGGC TGGTTGTCCT TAACCCCTGT CTCCTTCTGG ACCAGTTTTT GTCCTTCCCT TGTGACCGCT GAGGGGTAAC AGCCTCTTTC CACTTTCTTT CAGCGCCGAC ATGCTCAATG TCACCTTGCA AGGGCCCACT CTTAACGGGA CCTTTGCCCA GAGCAAATGC CCCCAAGTGG AGTGGCTGGG CTGGCTCAAC ACCATCCAGC CCCCCTTCCT CTGGGTGCTG TTCGTGCTGG CCACCCTAGA GAACATCTTT GTCCTCAGCG TCTTCTGCCT GCACAAGAGC AGCTGCACGG TGGCAGAGAT CTACCTGGGG AACCTGGCCG CAGCAGACCT GATCCTGGCC TGCGGGCTGC CCTTCTGGGC CATCACCATC TCCAACAACT TCGACTGGCT CTTTGGGGAG ACGCTCTGCC GCGTGGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG CATCTGTTTC CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG ATGCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTGGGGGTG TACGCTGCTC CTGAGCTCAC CCATGCTGGT GTTCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC GTCACCGCTT GTGTCATCAG CTACCCATCC CTCATCTGGG AAGTGTTCAC CAACATGCTC CTGAATGTCG TGGGCTTCCT GCTGCCCCTG AGTGTCATCA CCTTCTGCAC GATGCAGATC ATGCAGGTGC TGCGGAACAA CGAGATGCAG AAGTTCAAGG AGATCCAGAC GGAGAGGAGG GCCACGGTGC TAGTCCTGGT TGTGCTGCTG CTATTCATCA TCTGCTGGCT GCCCTTCCAG ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGGCATCC TCTCCAGCTG CCAGGACGAG CGCATCATCG ATGTAATCAC ACAGATCGCC TCCTTCATGG CCTACAGCAA CAGCTGCCTC AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTTCCGAA AGAAGTCTTG GGAGGTGTAC CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA TTCAGATGGA GAACTCCATG GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTGCA GGACTGGGCA GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA ATTTGTGTAA GGATTGAGGG ACAGTTGCTT TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG AAATGAGTTG ATGTCTCCGG TAAAACACCG GAGACTAATT CCTGCCCTGC CCAATTTTGC AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA ACAGCATTAC TGTTCTTATT TGCTGCCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGTG GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA CTGAGCTTCC CTCCCGTGTG TTCTCCGTCC CTGCCCCAGC AAGACAACTT AGATCTCCAG GAGAACTGCC ATCCAGCTTT GGTGCAATGG CTGAGTGCAC AAGTGAGTTG TTGCCCTGGG TTTCTTTAAT CTATTCAGCT AGAACTTTGA AGGACAATTT CTTGCATTAA TAAAGGTTAA GCCCTGAGGG GTCCCTGATA ACAACCTGGA GACCAGGATT TTATGGCTCC CCTCACTGAT GGACAAGGAG GTCTGTGCCA AAGAAGAATC CAATAAGCAC ATATTGAGCA CTTGCTGTAT ATGCAGTATT GAGCACTGTA GGCAAGAGGG AAGAAAGAGA AGGAGCCATC TCCATCTTGA AGGAACTCAA AGACTCAAGT GGGAACGACT GGGCACTGCC ACCACCAGAA AGCTGTTCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA TATGGACAGC AGAAGGGGGA GCCAGGTTCC AGCTCACCAA TACTATTGCA CACCACCTGT CCTGCCTC CTGCAGAAAA CAGCCTGAGC TCCACCTCGG CTTCTCCTTG CCCTGGCTGG TTGTCCTTAA CCCCTGTCTC CTTCTGGACC AGTTTTTGTC CTTCCCTTGT GACCCTGAGG GGTAACAGCC TCTTTTCCAC TTTCTTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTT AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCCCC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTTTGTC CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC AACAACTTCG ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA TTCATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC TTCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT GNCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGCAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAGCTTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT CTTTAATCTA TTCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA CAAGGGAGGT CTGTGCCAAA GAAGAATCCA ATAAGCACAT ATTGAGCACT TGCTGTATAT GCAGTATTGA GCACTGTAGG CAAGAGGGAA GAAAGAGAAG GAGCCATCTC CATCTTGAAG GAACTCAAAG ACTCAAGTGG GAACGACTGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTC TTCTGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG AGGTCTAGA TGATCCTATC ACAACCTGAG AGTAGTTTTT ACTCCATTTA CAGGTGAGGT CATTGTGGTT CAAGGACGTT EPI-109 26

AAGTAACTTC CCCAGCTCAC ACGGCTTATA AGTAAGGCAG CCAGGATGTG AACCCAGTAG GACTATCTGG CTGCAAAGTC CCCACCCTCC CTCGCCATCT GTATCCTCCA ATCATCTTCA GTGCTTTGCT GATAGAAGGT ACGGAAATAC GATGCCACAG ACTGTCCAGG AAGACAGAAA CTAGGCAGAT GGGCTGGCCA TGGTCTCCAA GCCAGACTGG AATCTCCAGG TCTGGAATGA TATCATTTTT CTCTTTTAAT AAATTAACTC ACCCACCACA CGGCTTTGAG AGGCTCAAAG GTGACCAACT CCCTTGGGAG GGCCCCGGTT GATAAGGAAG GAATGTGAAT CCTCCCATCA CGGAAGCTTC AAGGAGGTCA AGGGTCCAAC ACTTGAGATT GTTAGTGCTG TTGGTGGATA CTGCAGAATA TCCAGTGGAG CCTCAGATGA AGAACATGAG GCCCCGTTTA GATCCAAGGA TCAGAGGGGG CTCTGTAAGA CCCAGGGGAG TCAGGTGCAC TGGAGCGCGG GCTGCAGAAA ACAGCCTGAG CTCCACCTCG GCTTCTCCTT GCCCTGGCTG GTTGTCCTTA ACCCCTGTCT CCTTCTGGAC CAGTTTTTGT CCTTCCCTTG TGACCTGAGG GGTAACAGCC TCTTTTCCAC TTTCTTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTT AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCCCC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTTTGTC CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC AACAACTTCG ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA TTCATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC TTCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTGTTGA TGTCTCCGGT AAAACACCGG AGACTAATTC CTGCCCTGCC CAATTTTCGA GGGAGCATGG CTGTGAGGAT GGGGTGAACT CACGCACAGC CAAGGACTCC AAAATCACAA CAGCATTACT GTTCTTATTT GCTGCCACAC CTGAGCCAGC CTGCTCCTTC CCAGGAGTGG AGGAGGCCTG GGGGAGGGAG AGGAGTGACT GAGCTTCCCT CCCGTGTGTT CTCCGTCCCT GCCCCAGCAA GACAACTTAG ATCTCCAGGA GAACTGCCAT CCACGTTTGG TGCAATGGCT GAGTGCACAA GTGAGTTGTT GCCCTGGGTT TCTTTAATCT ATCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTTGATAAC AACCTGGAGA CCAGGATTTT ATGGCTCCCC TCACTGATGG ACAAGGAGGT CTGTGCCAAA GAAGAATCAA TAAGCACATA TGAGCACTTC TGTATATCAG TATTGAGCAC TGTAGGCA ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTT GTGAGGACTC CGTGCCCACC ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG ACCTTTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TCTTTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTGGC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AATTTGTGTA AGGATTGAGG GACAGTTGCT T ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTC GTGAGGACTC CGTGCCCACC ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG ACCTTTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TCTTTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTGGC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AATTTGTGTA AGGATTGAGG GACAGTTGCT T GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGGGAC ATCAGGCTGC CCCGCAGTAC CAGGGAGCGA CTGAAGTGCC CATGCCGCTT GCTCCGGAGA AGGTGGGTGC CGGGCAGGGG CTGCTCCAGC CGCCTCACCT CTGCTGGGAG GACAAACTGT CCCAGCACAG AGGGAGGGAG GGAGGGCAGG CAGCGGGGAG AAGTTTCCCT GTGGTCGTGG GGAGTT GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGCCC ATGCCGCTTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTTTCCCTG TGGTCGTGGG GAGTT GAGCTCTTCA ATATTTTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA CACACCTTTT CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA CTGGCAAGTC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGTTTCC CTGTCTCCAT GATGATGGGA TCAGGCTTGA TTGCTGGTTT GTAGGCTTGT TATGAATCAA GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTTCC CCAGATCCAC TGGGCCCACT CTTATCTGTT CTCTTCTGAA GGAAGGGTTT TAAGGCTTCA AAAAAAAATG TTTTGAAAGT CCCTGCCCTT TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAAAC TGAGAAAGCC AGCCTGAGCC TTGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGCC ACTGTCGCCC TTGGGAGCCG TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTTTA CACCTTCCGC GTAAACGCCC ACTGTTTACA TCCAAAACTC AGACACAAAA TAACCACCTC AAGAAGATAA ATAATGATAA GAAATAAATG TTACGCGAGG CAAATTTATT CACATGGGGC TTCCCAGGCC ACTTTGTGGT CAGCCGGGAG GGACGTTTTT GCCGTCCCAC GACTCCAACG GGCAGCCGGG CCTACGCAAA CATGGAAATC TTCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCTT CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCTTCAAAG ATGAGCTGTT CCCGCCGCCA CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGAGAAG GTGGGTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AGTTGGGAAA AGTTCCCTTC CTTCCGGAGG GAGG CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT GCCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAGCTTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT CTTTAATCTA TTCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA TTGAGCACTT GCTGTATATG CAGTATTGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCTTGAAGG AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTT TTATGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC GGTGTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTT CCACCTGTCA TTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCATTTGGAG AGAAGGCCAT GTCTTCAAAG TCTGATTTGT GATGAGGCAG AGGAAGATAT TTCTAATCGG TCTTGCCCAG AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG GCCTGCTCAG GGACTGTTCC TGTCTCAGCA ACCAAGGGAT TGTTCCTGTC AATCAATGGT TTATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGTGT TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT AAATGAATAT TTATTAGCTG GTTGGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA ACCTAGAAGG GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGTTA GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATTTACAT GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAAT TTTAAAGCAA AAGCGTGAAA AAAAAGATTC CCTCCTTACC CCCAACCCAC TCTTTTTTCC CACCACCCAC TCTCCTCTGC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATTTAGTATT AGTATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC TGTGTTTTGT CACACAGGGC AGTCATTCAG CACCAGAGCA CGTGATGGTC TGAGACTCTC TTAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC TGTCCTGTGA AAGACTCAAT GAGCTGTTAT GTTGTAAACA GGAAGCATTT CACATCCAAA CGAGAAAATC ATGTAAACAT EPI-109 28

GTGTCTTTTC TGTAGAGCAT AATAAATGGA TGAGGTTTTT GCAAAAAAAA AAAAAAAAA AAATGATAGA CCGTCAATAA TTTGTTAAAT GCTTTTTAAA ATGAATGCTT TAAGCCGGGT GCAGTGCCTC ACATCTGTAA TCCCAGCACT TTGGAGCCGA GCGGGTGGAT TGTGTGAGGT CAGGAGTTCG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCTCTACC AAAAATACAA AAATTAGCCA GGCATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG GAGAATCGCT TGAACCCGGG AGGCAAGGTT GCAGTGAGCC AAGATTACGC CATTGTACTC CAGCCTGGGT GACAGAGAGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATTAC GCTTCAAACA CATGATCTCT CACCACTGTT GAATTTTCTT TCTATGAGCC CAGGAGGGCC TCTCAGAGAG GAAAGCTCCT AGGTCTTCCT TTCCCTCTGC AAACTCCCTG CCTTGAAGGT TCAGAAGGAC TGTGCGTGCT CGTTGCATCC TTTGCAAGTG TCCAAACCCT GATCCCAGCT GTGCTTAGGG GTTCCTGCAA ACCTTTTCCA GGTGTTAATT ACCTCCCACT TCATTTCCTG TTTACCAACT CAGCTTTTTG TTTTAGTGTG TTTGAATTCC CTGAACTGAC CGTTGTCTGA TCTCCACCTC CCAACTGAAT TAGGGGAGCT GGGCTTCTGG AAACCCAGGT GCCGGGTGTT GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACACACAC ACCCACATAC CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TTGGACATGC ATAGACCACA GCTTTCCACA CCCTTCCTAG ACAGGGGTCA CTTGGTATCC TGGAGAGAGT GTGAAGTCCT GGAATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA CAAGTCACCA CCAACCCATC TGCGCCTTGT TTACCTCCTC TGTGAGGCAA GCACAGAGCC CATGCCTGCC CCCCTGGATG GGAGTGATGT GAAACTTGAA GGGCGGTCAG AGCAAGGGTC GGGAATGGAA GGCCCTTGGG AAAAAAGGCC CTTTCAACTA GGGGCACAGA GGAGGCCCTG GGCTGAGAAC TTGACAGCAC CTTGTAATTG GTAAGCCAAG CCCGAAGGGA CTGGAAATAC TCAGATGTGT CTGTCTCCCT TATTAGGTTC AAAGTCCCTC AAGACCCTGT CTCCATCACA GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGACCCAA CCAGCCCTAT GGGGTCGCAT CCCCACCTGC CTGGAATTCT CCAAAGAACC TCCCCTTTAA CAGTTCCAGC CTTTAACAGT TCCAGTCTAA ACACATGACC TTTCTCCTCT AAATCAGCCC CCCATCTCTG CCTTTGCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC CCATCCATGT CCAATCAAGC ACTAGGCATG TCAGGTTTAC CCTCTAAACT CCTCTGGAAT CCAGTCTCTC AGTCTCCATC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCTTGCTTC CACTCTACCC CCACTGCAGT CCTGACTTCC TGAGCAGCAG CCAGGGCCTA ATCGATATTC ACACCAAGCG CCAACCTGAC TGAGATATCC TCCTGCACCA TCATCCCTCC ACCCTGTTTA GTTCTGCTCA CCCTCAGTGT TCTCATCAAT AATCCACTCC CCTCACAGGC GCGTTTGGGA CCCCATGTTC TATGCTCTCA CAGGACCTTT TGCTTGATTT TTCACTGTAC TTAGGTCAGT TTGCAGTTAT TAAGTGACTG AGCAATGTCT GGCTTCTCCA GTAGACTGTC AGCTCCTAGC CATTGTATAC CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG AGTCAGGGAC TCAGCAGTCT CCATTTCTCC GCCCTGCTGG AGAATGCGTG TATTTGGCAA TCCCCAGCCC CTGTGCCATC TAACCATCTT TTCTTCTCTG TTCAGCCCAG GTGTGGCCTC ACTCACATCC CACTCTGAGT CCAAATGTTC TCTCCCTGGA AGATATCAAT GTTTCTGTCT GTTCGTGAGG ACTCCGTGCC CACCACGGCC TCTTTCAGGT GAGTCAAAGG GATTCCTCAG TTCACTAGTT AGGGGAGGTG GGCAGACACC CTGGAGAACT CCCTGGAAAG CTCAACTCTC ATGCCCCGGA CAACAGTTGA AGGAACCATG GTGATGTTAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGTTG GAATCTTGGG AGCAGAGGGA ATGTTCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA AGGGCACATT CCTGGTTGTT ATATGTTTCT ATCTATCCCA GATGAACTTG GAAGTGAAGG GAAGAGAGTT AAACATTAAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC CTTGGAAACA AAATATCTCC AACACATGGC TGACATTTGG TGGGAGATCA GAACACCCTA AAGAGAGAAT TTAAGGGGAG GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC AGAGGATAGG GAGATCTGTT CTTGGGGACA GCATTTGCAA GAAACAAGGC TGAGGGGTCC ACTCCAACCT CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGGCCAT CTCAGCTGGG GCCACAGTGC ACTGGACCTA TAGTTTCCAA TTCCGCACTC AGCAGGCATC TTTCTGATGA TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCTTGGCT ACTGTCTTGC TGAGAAATTT ATAAGCAGCA TCTGGTGCTA TACTTTGGTC TCTAGTGAGT TAGCTCATGA AAGATGATAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GGTTTTCTGT AGCTACAGAA ATGGGGTTGA GGGTTGGACC AAGGGACTAC CCAGGGGAAG TCTTACCTTC AGAGGACTCT GGAAAGGAGG CTGCAAGTTT TCATGGGTCA AGAATTCAGA GCCCAGTAGA GACAGCTTAT CTCTGTTCCA AGATGTCTGG GGCCTTGGTT GGAAGATTCA AAGGCTAGGA AACCAGGAGC CACCAAAAGC GTAACTGGGG CCAGAGGATC CACTTTCAAG GTGGCAAGTT GGTTCCCCCC ATGTGGCTGC TTGAGTATCC TCACATGGCG GCTCACATCC TTCCAAGTAA GCAATGCAAA AGGCCAAGAA AGATGCTGCA AAGATGTTAT GACCTAGCCT CAGAAATCAC ACACCATCCC TGCCACCATT AGTAAGAAGT CCAGCCCACG TCCAGGAGAA GAGGAAGCAG ATTCCTCCTT TTGAAATGAA GAATATCAAG TAATTCGGGG GGCATATGAA AGCCACCACA CACCACAGGG ATCTTTTTAG AGCATACTTC TTATACCATC ACTGTAGTTC CTTAAGACTC AGGGGCAAAG CCTCACTTCC TTAGCACCCA GTGAAGACCA CGCTTACTCC CTCACTCAAC CTCTTGCTAC TTCCCACCTC TCCTGTCCAA CATCTAGTGT CACTTTCCAG AACATACCAA CAGCTTCCCC AGTTCTGTGC CTCTGCTCAG GCTGTTCCCC CTGCCTGGTC CACTTGTCCT CCTTCTTGTC CGGTCAAAAT GCTTCTTATC CTTCAAGACC CAGCTCTAGA GTCACCTCCA ACCCCTTACC CACCAGCCCC CTCTCCAAGT CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC CACCCTCTGG GCCACAGTTG TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG GTGTCTTCTT TGTGTTCTTG CACTCAGGGC AGAGCTCAGC ACAGAGCAGA CGCTCAAAAA ACATTTAAAG GATAGAAGCA TTGATTTGTG GGTCCCCCAG TCTGGCTCCA GGATGCCAGC CAGCTGCTCC TAGAAGCAAA CGGACTTTTC CTGGGAAATC CCAGAGGTGA TGATCAGTAA TCTCTCCCGT GACTCGTAGT TCAGCTCTTC CTCCATGAGC CTGACTATCA GTGGACCTTC CAGAAAGAGC CCCTTTTCCT TCTCTCACCC ACAGCACAGG GCACTGGGAA AATGCCCAAT GAGTCCTGCC TCTGGGTTGT GCTTTGGACT TTTCAGTGTG TCTCGCATCC ACTCTTCAAC TTGAATGTTG CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATTCAGGATG AGAGCAATAC CCTACTCCAA AGAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAATTTGC CCAAGACCAC ACAGCTAGGA GTGGAACTCA TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GGTAGAGATG AATTACAGCA ACAAGTCTAG AAAGGTGCCT GCCCTATGGT CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA GCCAGTGGGT TAAAGATGAG GTCACCAACA ACGGTGGTGT TGGAGTTTAC CACTGATAAT AAGGGTGCAA AATGTAAATT ACTAATGTTT ATTGAGCCTA GTGCAGTGCG TGGGGCATTT TGCACATTGT CTCTGATCCC TATGACAACC EPI-109 29

CTGAGAGGTA GTGGTTTTAA CTGCCATGTT ACAGGTGAGG TCATTGTGGT TCAAGGACGT TAAGTAACTT CCCCAGCGTG ACACGGCTTA TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT GGCTGCAAAG TCCCCACCCC CCTCGCCATC TGTATCCTCC AATCACTTCA GTGCTTTGCT GCATAGAAGG TAACGGAAAT CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCTC CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATT TTTCTCTTTT AATAAATTAA CTCACCCACC ACACGGCTTT GAGAGGCTCA AAGTTGACCA ACTCCCTTGG GAGGGCCCCG GTTGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC TTCAAGGAGG TCAAGGGTCC AACACTTGAG ATTGTTAGTG CTGTTGGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC CTCGAGATGA AGAACATGAG GCCCCCGTTT AGAACCAAGG ATCAGAGGGG GCTCTGTAAG ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT CGGCTTCTCC TTGTCCTGGC TGGTTGTCCT TAACCCCTGT CTCCTTCTGG ACCAGTTTTT GTCCTTCCCT TGTGACCGCT GAGGGGTAAC AGCCTCTTTC CACTTTCTTT CAGCGCCGAC ATGCTCAATG TCACCTTGCA AGGGCCCACT CTTAACGGGA CCTTTGCCCA GAGCAAATGC CCCCAAGTGG AGTGGCTGGG CTGGCTCAAC ACCATCCAGC CCCCCTTCCT CTGGGTGCTG TTCGTGCTGG CCACCCTAGA GAACATCTTT GTCCTCAGCG TCTTCTGCCT GCACAAGAGC AGCTGCACGG TGGCAGAGAT CTACCTGGGG AACCTGGCCG CAGCAGACCT GATCCTGGCC TGCGGGCTGC CCTTCTGGGC CATCACCATC TCCAACAACT TCGACTGGCT CTTTGGGGAG ACGCTCTGCC GCGTGGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG CATCTGTTTC CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG ATGCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTGGGGGTG TACGCTGCTC CTGAGCTCAC CCATGCTGGT GTTCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC GTCACCGCTT GTGTCATCAG CTACCCATCC CTCATCTGGG AAGTGTTCAC CAACATGCTC CTGAATGTCG TGGGCTTCCT GCTGCCCCTG AGTGTCATCA CCTTCTGCAC GATGCAGATC ATGCAGGTGC TGCGGAACAA CGAGATGCAG AAGTTCAAGG AGATCCAGAC GGAGAGGAGG GCCACGGTGC TAGTCCTGGT TGTGCTGCTG CTATTCATCA TCTGCTGGCT GCCCTTCCAG ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGGCATCC TCTCCAGCTG CCAGGACGAG CGCATCATCG ATGTAATCAC ACAGATCGCC TCCTTCATGG CCTACAGCAA CAGCTGCCTC AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTTCCGAA AGAAGTCTTG GGAGGTGTAC CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA TTCAGATGGA GAACTCCATG GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTGCA GGACTGGGCA GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA ATTTGTGTAA GGATTGAGGG ACAGTTGCTT TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG AAATGAGTTG ATGTCTCCGG TAAAACACCG GAGACTAATT CCTGCCCTGC CCAATTTTGC AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA ACAGCATTAC TGTTCTTATT TGCTGCCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGTG GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA CTGAGCTTCC CTCCCGTGTG TTCTCCGTCC CTGCCCCAGC AAGACAACTT AGATCTCCAG GAGAACTGCC ATCCAGCTTT GGTGCAATGG CTGAGTGCAC AAGTGAGTTG TTGCCCTGGG TTTCTTTAAT CTATTCAGCT AGAACTTTGA AGGACAATTT CTTGCATTAA TAAAGGTTAA GCCCTGAGGG GTCCCTGATA ACAACCTGGA GACCAGGATT TTATGGCTCC CCTCACTGAT GGACAAGGAG GTCTGTGCCA AAGAAGAATC CAATAAGCAC ATATTGAGCA CTTGCTGTAT ATGCAGTATT GAGCACTGTA GGCAAGAGGG AAGAAAGAGA AGGAGCCATC TCCATCTTGA AGGAACTCAA AGACTCAAGT GGGAACGACT GGGCACTGCC ACCACCAGAA AGCTGTTCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA TATGGACAGC AGAAGGGGGA GCCAGGTTCC AGCTCACCAA TACTATTGCA CACCACCTGT CCTGCCTC CTGCAGAAAA CAGCCTGAGC TCCACCTCGG CTTCTCCTTG CCCTGGCTGG TTGTCCTTAA CCCCTGTCTC CTTCTGGACC AGTTTTTGTC CTTCCCTTGT GACCCTGAGG GGTAACAGCC TCTTTTCCAC TTTCTTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTT AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCCCC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTTTGTC CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC AACAACTTCG ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA TTCATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC TTCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT GNCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGCAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAGCTTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT CTTTAATCTA TTCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA CAAGGGAGGT CTGTGCCAAA GAAGAATCCA ATAAGCACAT ATTGAGCACT TGCTGTATAT GCAGTATTGA GCACTGTAGG CAAGAGGGAA GAAAGAGAAG GAGCCATCTC CATCTTGAAG GAACTCAAAG ACTCAAGTGG GAACGACTGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA EPI-109 30

GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTC TTCTGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG AGGTCTAGA TGATCCTATC ACAACCTGAG AGTAGTTTTT ACTCCATTTA CAGGTGAGGT CATTGTGGTT CAAGGACGTT AAGTAACTTC CCCAGCTCAC ACGGCTTATA AGTAAGGCAG CCAGGATGTG AACCCAGTAG GACTATCTGG CTGCAAAGTC CCCACCCTCC CTCGCCATCT GTATCCTCCA ATCATCTTCA GTGCTTTGCT GATAGAAGGT ACGGAAATAC GATGCCACAG ACTGTCCAGG AAGACAGAAA CTAGGCAGAT GGGCTGGCCA TGGTCTCCAA GCCAGACTGG AATCTCCAGG TCTGGAATGA TATCATTTTT CTCTTTTAAT AAATTAACTC ACCCACCACA CGGCTTTGAG AGGCTCAAAG GTGACCAACT CCCTTGGGAG GGCCCCGGTT GATAAGGAAG GAATGTGAAT CCTCCCATCA CGGAAGCTTC AAGGAGGTCA AGGGTCCAAC ACTTGAGATT GTTAGTGCTG TTGGTGGATA CTGCAGAATA TCCAGTGGAG CCTCAGATGA AGAACATGAG GCCCCGTTTA GATCCAAGGA TCAGAGGGGG CTCTGTAAGA CCCAGGGGAG TCAGGTGCAC TGGAGCGCGG GCTGCAGAAA ACAGCCTGAG CTCCACCTCG GCTTCTCCTT GCCCTGGCTG GTTGTCCTTA ACCCCTGTCT CCTTCTGGAC CAGTTTTTGT CCTTCCCTTG TGACCTGAGG GGTAACAGCC TCTTTTCCAC TTTCTTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTT AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCCCC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTTTGTC CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC AACAACTTCG ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA TTCATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC TTCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTGTTGA TGTCTCCGGT AAAACACCGG AGACTAATTC CTGCCCTGCC CAATTTTCGA GGGAGCATGG CTGTGAGGAT GGGGTGAACT CACGCACAGC CAAGGACTCC AAAATCACAA CAGCATTACT GTTCTTATTT GCTGCCACAC CTGAGCCAGC CTGCTCCTTC CCAGGAGTGG AGGAGGCCTG GGGGAGGGAG AGGAGTGACT GAGCTTCCCT CCCGTGTGTT CTCCGTCCCT GCCCCAGCAA GACAACTTAG ATCTCCAGGA GAACTGCCAT CCACGTTTGG TGCAATGGCT GAGTGCACAA GTGAGTTGTT GCCCTGGGTT TCTTTAATCT ATCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTTGATAAC AACCTGGAGA CCAGGATTTT ATGGCTCCCC TCACTGATGG ACAAGGAGGT CTGTGCCAAA GAAGAATCAA TAAGCACATA TGAGCACTTC TGTATATCAG TATTGAGCAC TGTAGGCA ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTT GTGAGGACTC CGTGCCCACC ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG ACCTTTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TCTTTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTGGC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AATTTGTGTA AGGATTGAGG GACAGTTGCT T ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTC GTGAGGACTC CGTGCCCACC ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG ACCTTTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TCTTTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG GAGATCCAGA CGGAGAGGAG EPI-109 31

GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTGGC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AATTTGTGTA AGGATTGAGG GACAGTTGCT T GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGGGAC ATCAGGCTGC CCCGCAGTAC CAGGGAGCGA CTGAAGTGCC CATGCCGCTT GCTCCGGAGA AGGTGGGTGC CGGGCAGGGG CTGCTCCAGC CGCCTCACCT CTGCTGGGAG GACAAACTGT CCCAGCACAG AGGGAGGGAG GGAGGGCAGG CAGCGGGGAG AAGTTTCCCT GTGGTCGTGG GGAGTT GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGCCC ATGCCGCTTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTTTCCCTG TGGTCGTGGG GAGTT GAGCTCTTCA ATATTTTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA CACACCTTTT CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA CTGGCAAGTC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGTTTCC CTGTCTCCAT GATGATGGGA TCAGGCTTGA TTGCTGGTTT GTAGGCTTGT TATGAATCAA GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTTCC CCAGATCCAC TGGGCCCACT CTTATCTGTT CTCTTCTGAA GGAAGGGTTT TAAGGCTTCA AAAAAAAATG TTTTGAAAGT CCCTGCCCTT TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAAAC TGAGAAAGCC AGCCTGAGCC TTGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGCC ACTGTCGCCC TTGGGAGCCG TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTTTA CACCTTCCGC GTAAACGCCC ACTGTTTACA TCCAAAACTC AGACACAAAA TAACCACCTC AAGAAGATAA ATAATGATAA GAAATAAATG TTACGCGAGG CAAATTTATT CACATGGGGC TTCCCAGGCC ACTTTGTGGT CAGCCGGGAG GGACGTTTTT GCCGTCCCAC GACTCCAACG GGCAGCCGGG CCTACGCAAA CATGGAAATC TTCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCTT CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCTTCAAAG ATGAGCTGTT CCCGCCGCCA CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGAGAAG GTGGGTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AGTTGGGAAA AGTTCCCTTC CTTCCGGAGG GAGG GAATTCGGGA AAAAGTGAAG GTGTAAAAGC AGCACAAGTG CAATAAGAGA TATTTCCTCA AATTTGCCTC AAGATGGAAA CCCTTTGCCT CAGGGCATCC TTTTGGCTGG CACTGGTTGG ATGTGTAATC AGTGATAATC CTGAGAGATA CAGCACAAAT CTAAGCAATC ATGTGGATGA TTTCACCACT TTTCGTGGCA CAGAGCTCAG CTTCCTGGTT ACCACTCATC AACCCACTAA TTTGGTCCTA CCCAGCAATG GCTCAATGCA CAACTATTGC CCACAGCAGA CTAAAATTAC TTCAGCTTTC AAATACATTA ACACTGTGAT ATCTTGTACT ATTTTCATCG TGGGAATGGT GGGGAATGCA ACTCTGCTCA GGATCATTTA CCAGAACAAA TGTATGAGGA ATGGCCCCAA CGCGCTGATA GCCAGTCTTG CCCTTGGAGA CCTTATCTAT GTGGTCATTG ATCTCCCTAT CAATGTATTT AAGCTGCTGG CTGGGCGCTG GCCTTTTGAT CACAATGACT TTGGCGTATT TCTTTGCAAG CTGTTCCCCT TTTTGCAGAA GTCCTCGGTG GGGATCACCG TCCTCAACCT CTGCGCTCTT AGTGTTGACA GGTACAGAGC AGTTGCCTCC TGGAGTCGTG TTCAGGGAAT TGGGATTCCT TTGGTAACTG CCATTGAAAT TGTCTCCATC TGGATCCTGT CCTTTATCCT GGCCATTCCT GAAGCGATTG GCTTCGTCAT GGTACCCTTT GAATATAGGG GTGAACAGCA TAAAACCTGT ATGCTCAATG CCACATCAAA ATTCATGGAG TTCTACCAAG ATGTAAAGGA CTGGTGGCTC TTCGGGTTCT ATTTCTGTAT GCCCTTGGTG TGCACTGCGA TCTTCTACAC CCTCATGACT TGTGAGATGT TGAACAGAAG GAATGGCAGC TTGAGAATTG CCCTCAGTGA ACATCTTAAG CAGCGTCGAG AAGTGGCAAA AACAGTTTTC TGCTTGGTTG TAATTTTTGC TCTTTGCTGG TTCCCTCTTC ATTTAAGCCG TATATTGAAG AAAACTGTGT ATAACGAGAT GGACAAGAAC CGATGTGAAT TACTTAGTTT CTTACTGCTC ATGGATTACA TCGGTATTAA CTTGGCAACC ATGAATTCAT GTATAAACCC CATAGCTCTG TATTTTGTGA GCAAGAAATT TAAAAATTGT TTCCAGTCAT GCCTCTGCTG CTGCTGTTAC CAGTCCAAAA GTCTGATGAC CTCGGTCCCC ATGAACGGAA CAAGCATCCA GTGGAAGAAC CACGATCAAA ACAACCACAA CACAGACCGG AGCAGCCATA AGGACAGCAT GAACTGACCA CCCTTAGAAG CACTCCTCGG TACTCCCATA ATCCTCTCGG AGAAAAAAAT CACAAGGCAA CTGTGAGTCC GGGAATCTCT TCTCTGATCC TTCTTCCTTA ATTCACTCCC ACACCCAAGA AGAAATGCTT TCCAAAACCG CAAGGGTAGA CTGGTTTATC CACCCACAAC ATCTACGAAT CGTACTTCTT TAATTGATCT AATTTACATA TTCTGCGTGT TGTATTCAGC ACTAAAAAAT GGTGGGAGCT GGGGGAGAAT GAAGACTGTT AAATGAAACC AGAAGGATAT TTACTACTTT TGCATGAAAA TAGAGCTTTC AAGTACATGG CTAGCTTTTA TGGCAGTTCT GGTGAATGTT CAATGGGAAC TGGTCACCAT GAAACTTTAG AGATTAACGA CAAGATTTTC TA<_TTTTTTT AAGTGATTTT TTTGTCCTTC AGCCAAACAC AATATGGGCT CAAGTCACTT TTATTTGAAA TGTCATTTGG TGCCAGTATC CCGAATTC GCCACCATGG AAACCCTTTG CCTCAGGGCA TCCTTTTGGC TGGCACTGGT TGGATGTGTA ATCAGTGATA ATCCTGAGAG ATACAGCACA AATCTAAGCA ATCATGTGGA TGATTTCACC ACTTTTCGTG GCACAGAGCT CAGCTTCCTG GTTACCACTC ATCAACCCAC TAATTTGGTC CTACCCAGCA ATGGCTCAAT GCACAACTAT TGCCCACAGC AGACTAAAAT TACTTCAGCT TTCAAATACA TTAACACTGT GATATCTTGT ACTATTTTCA TCGTGGGAAT GGTGGGGAAT GCAACTCTGC TCAGGATCAT TTACCAGAAC AAATGTATGA GGAATGGCCC CAACGCGCTG ATAGCCAGTC TTGCCCTTGG AGACCTTATC TATGTGGTCA EPI-109 32

TTGATCTCCC TATCAATGTA TTTAAGCTGC TGGCTGGGCG CTGGCCTTTT GATCACAATG ACTTTGGCGT ATTTCTTTGC AAGCTGTTCC CCTTTTTGCA GAAGTCCTCG GTGGGGATCA CCGTCCTCAA CCTCTGCGCT CTTAGTGTTG ACAGGTACAG AGCAGTTGCC TCCTGGAGTC GTGTTCAGGG AATTGGGATT CCTTTGGTAA CTGCCATTGA AATTGCCTCC ATCTGGATCC TGTCCTTTAT CCTGGCCATT CCTGAAGCGA TTGGCTTCGT CATGGTACCC TTTGAATATA GGGGTGGACA GCATAAAACC TGTATGCTCA ATGCCACATC AAAATTCATG GAGTTCTACC AAGATGTAAA GGACTGGTGG CTCTTCGGGT TCTATTTCTG TATGCCCTTG GTGTGCACTG CGATCTTCTA CACCCTCATG ACTGGTGAGA TGTTGAACAG AAGGAATGGC AGCTTGAGAA TTGCCCTCAG TGAACATCTT AAGCAGCGTC GAGAAGTGGC AAAAACAGTT TTCTGCTTGG TTGTAATTTT TGCTCTTTGC TGGTTCCCTC TTCATTTAAG CCGTATATTG AAGAAAACTG TGTATAACGA GATGGACAAG AACCGATGTG AATTACTTAG TTTCTTACTG CTCATGGATT ACATCGGTAT TAACTTGGCA ACCATGAATT CATGTATAAA CCCCATAGCT CTGTATTTTG TGAGCAAGAA ATTTAAAAAT TGTTTCCAGT CATGCCTCTG CTGCTGCTGT TACCAGTCCA AAAGTCTGAT GACCTCGGTC CCCATGAACG GAACAAGCAT CCAGTGGAAG AACCACGATC AAAACAACCA CAACACAGAC CGGAGCAGCC ATAAGGACAG CATGAACTGA CCACCCTTAG AAGCACTCCT GAATTCGGGA AAAAGTGAAG GTGTAAAAGC AGCACAAGTG CAATAAGAGA TATTTCCTCA AATTTGCCTC AAGATGGAAA CCCTTTGCCT CAGGGCATCC TTTTGGCTGG CACTGGTTGG ATGTGTAATC AGTGATAATC CTGAGAGATA CAGCACAAAT CTAAGCAATC ATGTGGATGA TTTCACCACT TTTCGTGGCA CAGAGCTCAG CTTCCTGGTT ACCACTCATC AACCCACTAA TTTGGTCCTA CCCAGCAATG GCTCAATGCA CAACTATTGC CCACAGCAGA CTAAAATTAC TTCAGCTTTC AAATACATTA ACACTGTGAT ATCTTGTACT ATTTTCATCG TGGGAATGGT GGGGAATGCA ACTCTGCTCA GGATCATTTA CCAGAACAAA TGTATGAGGA ATGGCCCCAA CGCGCTGATA GCCAGTCTTG CCCTTGGAGA CCTTATCTAT GTGGTCATTG ATCTCCCTAT CAATGTATTT AAGCTGCTGG CTGGGCGCTG GCCTTTTGAT CACAATGACT TTGGCGTATT TCTTTGCAAG CTGTTCCCCT TTTTGCAGAA GTCCTCGGTG GGGATCACCG TCCTCAACCT CTGCGCTCTT AGTGTTGACA GGTACAGAGC AGTTGCCTCC TGGAGTCGTG TTCAGGGAAT TGGGATTCCT TTGGTAACTG CCATTGAAAT TGTCTCCATC TGGATCCTGT CCTTTATCCT GGCCATTCCT GAAGCGATTG GCTTCGTCAT GGTACCCTTT GAATATAGGG GTGAACAGCA TAAAACCTGT ATGCTCAATG CCACATCAAA ATTCATGGAG TTCTACCAAG ATGTAAAGGA CTGGTGGCTC TTCGGGTTCT ATTTCTGTAT GCCCTTGGTG TGCACTGCGA TCTTCTACAC CCTCATGACT TGTGAGATGT TGAACAGAAG GAATGGCAGC TTGAGAATTG CCCTCAGTGA ACATCTTAAG CAGCGTCGAG AAGTGGCAAA AACAGTTTTC TGCTTGGTTG TAATTTTTGC TCTTTGCTGG TTCCCTCTTC ATTTAAGCCG TATATTGAAG AAAACTGTGT ATAACGAGAT GGACAAGAAC CGATGTGAAT TACTTAGTTT CTTACTGCTC ATGGATTACA TCGGTATTAA CTTGGCAACC ATGAATTCAT GTATAAACCC CATAGCTCTG TATTTTGTGA GCAAGAAATT TAAAAATTGT TTCCAGTCAT GCCTCTGCTG CTGCTGTTAC CAGTCCAAAA GTCTGATGAC CTCGGTCCCC ATGAACGGAA CAAGCATCCA GTGGAAGAAC CACGATCAAA ACAACCACAA CACAGACCGG AGCAGCCATA AGGACAGCAT GAACTGACCA CCCTTAGAAG CACTCCTCGG TACTCCCATA ATCCTCTCGG AGAAAAAAAT CACAAGGCAA CTGTGAGTCC GGGAATCTCT TCTCTGATCC TTCTTCCTTA ATTCACTCCC ACACCCAAGA AGAAATGCTT TCCAAAACCG CAAGGGTAGA CTGGTTTATC CACCCACAAC ATCTACGAAT CGTACTTCTT TAATTGATCT AATTTACATA TTCTGCGTGT TGTATTCAGC ACTAAAAAAT GGTGGGAGCT GGGGGAGAAT GAAGACTGTT AAATGAAACC AGAAGGATAT TTACTACTTT TGCATGAAAA TAGAGCTTTC AAGTACATGG CTAGCTTTTA TGGCAGTTCT GGTGAATGTT CAATGGGAAC TGGTCACCAT GAAACTTTAG AGATTAACGA CAAGATTTTC TACTTTTTTT AAGTGATTTT TTTGTCCTTC AGCCAAACAC AATATGGGCT CAAGTCACTT TTATTTGAAA TGTCATTTGG TGCCAGTATC CCGAATTC AACAAGAAAA GCGTTGGTAG CTCTGGTGAA TCCCAAAAGA ATGTGGCAGT TGCTAGCCAT GCTCCTGAAT ATGTATAAAC AGTACATCAT ATGACTAAGA GTTTGACTTA GGGGTTAGAT TTTATGTGTT TGAACCCCAA ATTAGTTATT TAATAGTTGG CACCCCAAAA CAAGTTACTT AACCTCACTA AGGTTCAGTT TTCCTGTTTA TAAAATGTAG ATAGTGATAG TATGTACTTT ATAGGATTAT TGTGAAAAAT AAATGAAATA TCAGATTTAT TTAGGATAAC ACCTGGCATA TGTTTGGTAT TCAGAATTAG TTGCTGCTGT TTTATTCTGC TCTCCCTTGC ATCCCACTTT TCTAAGTTGT AAACTAAATA GTTGTACACA GATTGACAGA TTAAGAAAGG CTTGTGATTG TGCTAGACCT ATGCCTATGC CTCTGTCTCA CCAGATTCCA GGTGTATATG TGGAGGTGGG ATAGGGAGTG GAGTAAGTGG GTAAATATTA AATTGCCCAG TTGGGCACCA TCCTGAATAT TATCTCTAAA GAAAGAAGCA AAACCAGGCA CAGCTGATGG GTTAACCAGA TATGATACAG AAAACATTTC CTTCTGCTTT TTGGTTTTAA GCCTATATTT GAAGCCTTAG ATCTCTCCAG CACAGTAAGC ACCAGGAGTC CATGAAGAAG ATG GATCTTCATG TGGAATGACT GGTTTCATTC AATAGACTTA

ATTCAGCAGT CTGTGGGGAA GAGCAAGGTA TGATAGAATG GTTCCTCAAG TGCTTCAGAT GTGAAGTGGG TTTAAATATA CTGTCCCTGT CTTCTTCAGA GTTTTGGTAA AGATAAAATA GGACACTCAT TTAAAAGCAA TCTTTGCAAA TGACAAGCCA CTATAGACAT TAATAGAGTT TTCATTTCCA GTATTATCAT TAATATCAGA TCCTGGAAGA AGGTTGAGCC TTGACCTAGA GCAAAAAAAC AGAAGAATTA GTAAAGGAAT CCTGGAGAAA GCCCCTGCTG TGTATTTAAA GGAGAAAGGG AGATCATGTT GGGAAATTAT AATATTAAAA GTAAACAAAA GCTAGGAAGT AAAATAAAAT AAATTATATG GCCTAGATCC CCATAAGTAA TGGTTTAACT TCTGCCTTCC TGTGTTCTGA GCCAGATTAG GGCACAGTAG AGAAAGAGGA GTCTCTGAAA ATGTTTCCAA TTTCGCTGGT CAGACAGCGG ATCATCAGTG AATCAGATGA AAATTTGTGG ATTTATGCAC TAACTGATCA GCAGGAAATT AAACAAGAAA AGCGTTGGTA GCTCTGGTGA ATCCCAAAAG AATTTGGCAG TTGCTAGCCA TGCTCCTGAA TATGTATAAA CAGTACATCA TATGACTAAG AGTTTGACTT AGGGGTTAGA TTTTATGTGT TTGAACCCCA AATTAGTTAT TTAATAGTTG GCACCCCAAA ACAAGTTACT TAACCTCACT AAGATTCAGT TTTCCTGTTT ATAAAATGTA GATAGTGATA GTATGTACTT TATAGGATTA TTGTGAAAAA TAAATGAAAT ATCAGATTTA TTTAGGATAA CACCTGGCAT ATGTTTGGTA TTCAGTAATT AGTTGCTGCT GTTTTATTCT GCTCTCCCTT GCATCCCACT TTTCTAAGTT GTAAACTAAA TAGTTGTACA CAGATTGACA GATTAAGAAA GGCTTGTGAT TGTGCTAGAC CTATGCCTCT CTCTCACCAG ATTCCAGGTG TATATGTGGA GGTGGGATAG GGAGTGGAGT AAGTGGGTAA ATATTAAATT GCCCAGTTGG GCACCATCCT GAATATTATC TCTAAAGAAA GAAGCAAAAC CAGGCACAGC TGATGGGTTA ACCAGATATG ATACAGAAAA CATTTCCTTC TGCTTTTTGG TTTTAAGCCT ATATTTGAAG EPI-109 33

CCTTAGATCT CTCCAGCACA GTAAGCACCA GGAGTCCATG AAGAAGATGG CTCCTGCCAT GGAATCCCCT ACTCTACTGT GTGTAGCCTT ACTGTTCTTC GGTAAGTAGA GATTCAATTA CCCCTCCCAG GGAGGCCCAA ATGAATTTGG GGAGCAGCTG GGGTAGGAAC CTTTACTGTG GGTGGTGACT TTTTCTAGGA CATGTGCAAA CTATTGGGCA TTTCCCAGGG ACTCTGTAGT GGAGCCAAGC TAGAAAGCAG AGGCAAGTGG GCTGAGCAAC ACCTAAGGAG GAAGCCAGAC TGAAAGCTTG GTTCCTTGCA TTTGCTCTGG CATCTTCCAG AGTGCAAATT TCCTACCAAG GTAATGAGGG TAGAGGAGAG AAAGAAGCTC TTTCTTCCCC TGATTCTCAT TCCTGAAAAG ACGGTTGGTC CTTAAAATTC CATGGATGTA GATCTTATCC CCACACCCAG ATTCTAGTCC TCTGGAGATA AAGAAGACTG CTGGACACTA ATGTATCCTC TCTGGACTTT TGCAGCTCCA GATGGCGTGT TAGCAGGTGA GTCCTCTGTT CTTGTTCCCT TGGTGTATCA ACATGTCTGG GCATTGCTTT CCTCTCACTA TTTTCTTCGT CCCATCACTT CTGCTTTCTA ATGAGCATGA ATCTGTTCCT TGGCCAGACT ACTTTCCCTC TCCACCTTGC CTTGTCTTTC TTTTTTTCCC TGATTCATTG CATTCTCTCA AGTCATTCTC TCCTCTGTTT TAGTCAATAA CCATGTCTGT TGCACATATA CATGTCTCAT TCTCTCTCCT AGACACTTTG GCATGATCTC GCTCAATAAT TACATTATTA TTATTATTGC CATTTTATAA TTGAGGATGC TGAAACTCAG TGATTTTCTG GTGGTTACAT GGCTAAGGAA CTGGATTTCA ACGTAAGTTC CTTGGATCTA AGTCCAGTTC TCTTCTGACT ATATCACCCT TTTGTTATCA CCATGTATCT ACTTCTTTGG TCTCTGTTCA AATTTGCACT ACATCCCCTT GTTCCAGGAA GCCATTCAAG ACTGACTTTC TTAGTGCCTC TCACTACTTT CTGGAACTGA CATATGTTTT TCACTCTGTA TATACTTACA ATTAAATAGT CATAAATATT CAGAGCTTGG AGAAACCTTA TATTTCATCC AGTCCAGTAA ATTTATCCAT CCATAATTCA CTCATTCATT CACATAATAA ATATTTAATG TAACAATGGT TGAACATGGC AGACAGTGTT TCTACCTCAA AAGAGATTGC AGTCCTCATT TACAGATACT GAATTGAAAT TAACAGAAGT AGAGTGAGTC AGCTCAAATC ACATAGTGAA TTGGTTTCTT TGTTTTTAAA TCTCCTGCAT ATGTGTCCTG TCTTTCTCCC TGTGTTGGGC GTTCCCTGGG GCACCAATAC TAATTTCTCC TTCCCCTAGA AATCAAAACA GGGTCTTATC ACCAACAGAA TAAGGACAGG TTGACCACTG ATTGTCAGAA TATTGCTTCG TTTGTACTTT TAAGCCTAGA CAGTTTTCAA TGACTTTTTT TCTCTCTACA TGTCTTTTCA TATTTTTATC TTCTTGAAGT CCCTCAGAAA CCTAAGGTCT CCTTGAACCC TCCATGGAAT AGAATATTTA AAGGAGAGAA TGTGACTCTT ACATGTAATG GGAACAATTT CTTTGAAGTC AGTTCCACCA AATGGTTCCA CAATGGCAGC CTTTCAGAAG AGACAAATTC AAGTTTGAAT ATTGTGAATG CCAAATTTGA AGACAGTGGA GAATACAAAT GTCAGCACCA ACAAGTTAAT GAGAGTGAAC CTGTGTACCT GGAAGTCTTC AGTGGTAAGT TCCAGGGATA TGGAAATACA GATCTCTCAT GTGAGGGATG GCTCATCTGA AGATGGGAAA AAACAGGTTA TTCCAAGGGT TAGGACACCA GAGTGGGATT CAAGGCCTCT CATTTTTAAG ACCCCTGCAT TGGCTGGGCA CAGTGGCTCA CGCCTGTAAT CCCAGCACTT TGGGAGGCTG AGGCAGGTGG ATCACGAGGT CAGGAGATCG AGACCATCCG GCTAACATGG TGAAACCCCA TCTCTGCTAA AAAATATATA TATATAAAAT TAGCCGGGCG TAGTGGTGGG CACCTGTAGT CCCAGGTACT CGGGAGGCTG AGGCAGGAGA ATGGTGTGAA CCCAGGAGGT GGAGGTTGCA GTGAGCTGAG ATCACGCCAC TGCCCTCCAG CCTGGGCTAC AGAGCAAGAC TCCGTCTCAA AAAATAAATA AATAAATAAA AAAGACCCCT GCATCTCTTT TCTTCTACCC CCTTCCCTTT TGATTACTTG TATGCCTTCT TTCAATATTC TAGTCATCTC TCAATATTAT TCCTCCACCC TATTTTCCTC TATCTTTTCT GCCTAGATTC AGGTATATAT TATGTGGTCA AACAGCATGA CATATATGTG AACATTTCAA AGAGCTGTGT ATCTGGAATA GGATCAAAAG GTTTGACTTA AAGTTTTGCT CTGCATAATC CATATGGCAG GACCTGAATA TTAGGTTGTA CTCTTCGTTA TGAAACATAT CTGGGTACAT TTCCTTATGT CCTCTGTTGT TACTTAAGAA CACATATTTC ATGCTTGTTT CATTTTTATC ACTCCTACTG CCAACAAATA GCATAGCATG CTTAGGCACA TGTGGCTTAA TTAGCAAATG TTGAATAAAC AAATTAATGA TTTTGAATAG TGACCAATAG GTCTCTTTTA TACTCTATAT TTTTCTCTTG AGTGAAAAAA AATGTTTCAA CCTCCATATG TAAATTCCAA ACACAAACTA AAGCAATGTA GAATAGCTTC TTTATTCCCT GGAGTAGGTT CTAGAGAAGT CCTAAAGGAT TGGTCCTAAA TTAATTATGC TTATTATGCT AGCGATATTT CCTTTCAAAA TTCTCCTTTA ATGAATGCTT TTTAATTTTT ACAAAAGCAT TAACCATAGA ATGTGATTCT TGTCTTTCAC TGACTCATTA GTGACAAATA TTTGTTGAGT ACCTACCAAC TCCTAAGTAT TGCTACCAAC TCCTAAATAC TGTGTTGGGC ATTCAGAATA GAATGTAGAA CTAGACAGGG TCCCTGACTT CTTGGAGCAC AGAGCAGTAT GGGAAGAGGA CATTAAATAA AGAATTACAT AAGTAATTAA TTTAAATTAT ACATGTTTTG AAGAAGTTTT TTTTTGACAA CTATAATTAA CACTAGAACT GGGAAGTTTC TATAAGGTAA GAGAGGACAA AATAGACACT CTCCTAAGCT AAAATTCCCA AGAAAGACTG TTTATTTTCC CCTAACTAAC TAGAACTAGC AACAGAAGAT CTGAAAGGAA TTCTGGCTTT CAAGTGTTCC ATGTATGGAC TCATCAGGGA GGTCCGAGAG GCTTTGTGGC CCCAGACTGA CTTTTCAGGA GGGGAAAGGA TTTATCAATA CACAAGACAG GCTCTAAGCA TTATTTTGTG CCCTTTAAAA ATCCACTTTA TGAGCCAAAA AGTGAGTTAA TGATAATTCA TAGTTTCTGA CACATGCTCT ATGCGTGGCT CTCTTTTCTC TATTCATTCT CTCTCTCTTC ATTTATTGTT AAATAAATAA TGTAATGAAT GTTCTTCAGA CTGGCTGCTC CTTCAGGCCT CTGCTGAGGT GGTGATGGAG GGCCAGCCCC TCTTCCTCAG GTGCCATGGT TGGAGGAACT GGGATGTGTA CAAGGTGATC TATTATAAGG ATGGTGAAGC TCTCAAGTAC TGGTATGAGA ACCACAACAT CTCCATTACA AATGCCACAG TTGAAGACAG TGGAACCTAC TACTGTACGG GCAAAGTGTG GCAGCTGGAC TATGAGTCTG AGCCCCTCAA CATTACTGTA ATAAAAGGTG AGTTGGTAAA GGAAAGGAAA AGCATCCATA GCAGGGGAAG GAAGAGAGAA CTTCTGAGCC TGAGCAGTTG CAGCTTGTAG AAGGGGGGCA CCTGTGATAC ACTGGAAAGC CTACCAGACT TGCAATGAGG AGACCTGGGT GATAGTATAT ATCTCAATCT CTGTTTCAAA GCCTTGACTT GTTAAATGGT GATAGTAATA CCTGCTTGCA CTATGAAATT TTTATGAAGA TTAATGTGGT AATATTTGTG AAATGACTTT GTAAACTGTT AAGCACTACC CAAGCATAAC AGATTGTGAT TACTATTTTG ATCTCAAAGT CATCTGTTGC TCCTGGGGGA ACACTTATAT TTATCAAATT GAAAAAAAGT TTCAAAGTTG AATGAAGAAA GGATATAAAG AGCTTGAGGA GCCCATTCCA GCTTAGGAGG GCTGGGAAAG GAAACCAGCA AGTCAGTAAG CTGTGTGCCT GTGTATTGAG GGAGGAGGGA ATGGACTTGA TATGGAGAGG GTAGGGAGGT GGACTGCCTC TATGGCCTGT AAGAAAAACT GCTCTCTCCA AACTCTTTAT AAGAGAGGGA GCCTGTGAAG TATTCACTTT TGAAGGAGAA AGTTAGACTT TTCCTTCACA CACTTTGTAC ATAATAATGT TTAAAAAAGC ATGAGGTCAA AATACATAAT TAAGTCCTAG CAGTTCTCTG TTAACTAATT TGAGACTGAA GTGCTATGTA CTTGTCTCTA GGCTTCCAGT ATCTTCATCT GTAAAACAGA ATATTTGGTC TAGATTCCAT EPI-109 34

TAGAATCATT TGATAACTTA AAAAATATAT TGATGCTCAT GTCTCATTTC TTGAGATTCT GATTTAATTG GTTTGGGGTG CAGCCTGGGT ATACGTATTT TTCATAGGTC TTTCACATAA TGGTAATGGG TAGCCAATAT TGAGAATCAC TTGTCTAGGT GATCTTTAAA TGATTTCTGG ATGTAATATT CTGAGGCTCT ATAATTTGAG ACTAATCACA AAAATCGGTA CAGTTTATAA ACAGACTAAC AGAACCACAA AATAATAGAA TTGGAAGGCA ATTTAACTAG TGCAATTTCT TCATTTTGCC TAACAGGCAT GTAAGAAATG ATGATTGATT GAGTAATAGG CATTGATGAC CCCTGTCCTC ACTTTGTCCC CTTTCCACCC CTTAATTATA TGTGAATTCT GGTCTTGTCA TTTCGAATAA GGGGTTTATC TTTCCTATTG TCTTCCCCTC TGGGCACGGC ACACTGGCTA CTGGAGTTAA GAGGAAATGC TTAGGACTCC CTGTGGCTCC AGGGAGCACC AACAGAGCAA CTCAACCTAG TGTTAATCTG AGTGTTTTCT CTGTGCTTCT GGATGCCACA TCACGCTAAA AATGAAGGAC AAAGCTTGGT CTTTCTCTTA GGGAGGATGA AACTCTGAAC CTCATTTTTC AGTTCCCAAG ATGAATTATG TTTCTCATTG CATCTGTGTT CCACTACAGC TCCGCGTGAG AAGTACTGGC TACAATTTTT TATCCCATTG TTGGTGGTGA TTCTGTTTGC TGTGGACACA GGATTATTTA TCTCAACTCA GCAGCAGGTC ACATTTCTCT TGAAGATTAA GAGAACCAGG AAAGGCTTCA GACTTCTGAA CCCACATCCT AAGCCAAACC CCAAAAACAA CTGATATAAT TACTCAAGAA ATATTTGCAA CATTAGTTTT TTTCCAGCAT CAGCAATTGC TACTCAATTG TCAAACACAG CTTGCAATAT ACATAGAAAC GTCTGTGCTC AAGGATTTAT AGAAATGCTT CATTAAACTG AGTGAAACTG GTTAAGTGGC ATGTAATAGT AAGTGCTCAA TTAACATTGG TTGAATAAAT GAGAGAATGA ATAGATTCAT TTATTAGCAT TTGTAAAAGA GATGTTCAAT TTCAATAAAA TAAATATAAA ACCATGTAAC AGAATGCTTC TGAGTATTCA AGGCTTGCTA GTTTGTTTGT TTGTTTTCTA CTAAAGGCAA GGACCATGAA GTTCTAGATT GGAAATGTCC TCTCTTGACT ATTGCAAGTG CGATCTAGGA ATGAAAAGAC ATAGGAGGAT GCCAGTGAGG TGGATCATTT TTATGCTTCT TCTTCAGCTT ACTAAATATG AACTTTCAGT TCTTGGCAGA ATCAGGGACA GTCTCAAGAC ATAGGACTCT CAGGATGAAG TAGAGTCCAG GATTCCTCTG TGATTGTTTT GCCCCTCCCA AATTTATATC TTGAACTTAT GTCTTGTATC TTTATACAGC ACCTGAACCA AGCATTTTGG AGAAATTCCA GCTAATAATA ATAACCAAAA CCTTCGGCTC TGAAAACAGT CCAGGACTGA ATAAGATCTT GGGCAAAAGA ACTAGACAGT TTTGGTTTAT TTTCCCTTTC ATTTTATGTC TTCATCATAG TCATTGGAGG CTCATTCTTC TTGTCATGGA GTAAATGGGA TTAAAGTTC TACTAAGAGT CTCCAGCATC CTCCACCTGT CTACCACCGA GCATGGGCCT ATATTTGAAG CCTTAGATCT CTCCAGCACA GTAAGCACCA GGAGTCCATG AAGAAGATGG CTCCTGCCAT GGAATCCCCT ACTCTACTGT GTGTAGCCTT ACTGTTCTTC GCTCCAGATG GCGTGTTAGC AGTCCCTCAG AAACCTAAGG TCTCCTTGAA CCCTCCATGG AATAGAATAT TTAAAGGAGA GAATGTGACT CTTACATGTA ATGGGAACAA TTTCTTTGAA GTCAGTTCCA CCAAATGGTT CCACAATGGC AGCCTTTCAG AAGAGACAAA TTCAAGTTTG AATATTGTGA ATGCCAAATT TGAAGACAGT GGAGAATACA AATGTCAGCA CCAACAAGTT AATGAGAGTG AACCTGTGTA CCTGGAAGTC TTCAGTGACT GGCTGCTCCT TCAGGCCTCT GCTGAGGTGG TGATGGAGGG CCAGCCCCTC TTCCTCAGGT GCCATGGTTG GAGGAACTGG GATGTGTACA AGGTGATCTA TTATAAGGAT GGTGAAGCTC TCAAGTACTG GTATGAGAAC CACAACATCT CCATTACAAA TGCCACAGTT GAAGACAGTG GAACCTACTA CTGTACGGGC AAAGTGTGGC AGCTGGACTA TGAGTCTGAG CCCCTCAACA TTACTGTAAT AAAAGCTCCG CGTGAGAAGT ACTGGCTACA ATTTTTTATC CCATTGTTGG TGGTGATTCT GTTTGCTGTG GACACAGGAT TATTTATCTC AACTCAGCAG CAGGTCACAT TTCTCTTGAA GATTAAGAGA ACCAGGAAAG GCTTCAGACT TCTGAACCCA CATCCTAAGC CAAACCCCAA AAACAACTGA TATAATTACT CAAGAAATAT TTGCAACATT AGTTTTTTTC CAGCATCAGC AATTGCTACT CAATTGTCAA ACACAGCTTG CAATATACAT AGAAACGTCT GTGCTCAAGG ATTTATAGAA ATGCTTCATT AAACTGAGTG AAACTGGTTA AGTGGCATGT AATAGTAAGT GCTCAATTAA CATTGGTTGA ATAAATGAGA GAATGAATAG ATTCATTTAT TAGCATTTGT AAAAGAGATG TTCAATTTCA ATAAAATAAA TATAAAACCA TGTAACAGAA TGCTTCTGAG TAAAAAAAAA AAAAAAAAAA AAAAAAAA TCTCAATATA ATAATATTCT TTATTCCTGG ACAGCTCGGT TAATGAAAAA ATGGACACAG AAAGTAATAG GAGAGCAAAT CTTGCTCTCC CACAGGAGCC TTCCAGTGTG CCTGCATTTG AAGTCTTGGA AATATCTCCC CAGGAAGTAT CTTCAGGCAG ACTATTGAAG TCGGCCTCAT CCCCACCACT GCATACATGG CTGACAGTTT TGAAAAAAGA GCAGGAGTTC CTGGGGGTAA CACAAATTCT GACTGCTATG ATATGCCTTT GTTTTGGAAC AGTTGTCTGC TCTGTACTTG ATATTTCACA CATTGAGGGA GACATTTTTT CATCATTTAA AGCAGGTTAT CCATTCTGGG GAGCCATATT TTTTTCTATT TCTGGAATGT TGTCAATTAT ATCTGAAAGG AGAAATGCAA CATATCTGGT GAGAGGAAGC CTGGGAGCAA ACACTGCCAG CAGCATAGCT GGGGGAACGG GAATTACCAT CCTGATCATC AACCTGAAGA AGAGCTTGGC CTATATCCAC ATCCACAGTT GCCAGAAATT TTTTGAGACC AAGTGCTTTA TGGCTTCCTT TTCCACTGAA ATTGTAGTGA TGATGCTGTT TCTCACCATT CTGGGACTTG GTAGTGCTGT GTCACTCACA ATCTGTGGAG CTGGGGAAGA ACTCAAAGGA AACAAGGTTC CAGAGGATCG TGTTTATGAA GAATTAAACA TATATTCAGC TACTTACAGT GAGTTGGAAG ACCCAGGGGA AATGTCTCCT CCCATTGATT TATAAGAATC ACGTGTCCAG AACACTCTGA TTCACAGCCA AGGATCCAGA AGGCCAAGGT CTTGTTAAGG GGCTACTGGA AAAATTTCTA TTCTCTCCAC AGCCTGCTGG TTTT AAGCTTTTCA AAGGTGCAAT TGGATAACTT CTGCCATGAG

AAATGGCTGA ATTGGGACAC AAGTGGGGAC AATTCCAGAA GAAGGGCACA TCTCTTTCTT TTCTGCAGTT CTTTCTCACC TTCTCAACTC CTACTAAAAT GTCTCATTTT CAGGTTCTGT AAATCCTGCT AGTCTCAGGC AAAATTATGC TCCAGGAGTC TCAAATTTTC TTATTTCATA TTAGTCTTTA TTTAGTAGAC TTCTCAATTT TTCTATTCAT CACAAGTAAA AGCCTGTTGA TCTTAATCAG CCAAGAAACT TATCTGTCTG GCAAATGACT TATGTATAAA GAGAATCATC AATGTCATGA GGTAACCCAT TTCAACTGCC TATTCAGAGC ATGCAGTAAG AGGAAATCCA CCAAGTCTCA ATATAATAAT ATTCTTTATT CCTGGACAGC TCGGTTAATG AAAAAATGGA CACAGAAAGT AATAGGAGAG CAAATCTTGC TCTCCCACAG GAGCCTTCCA GGTAGGTACA AGGTATTATT TTTTTCTACC CTCAGTCACT TGTGGCAGGG GAAGTCATAG TCACGGTGCT TAGGAGATGA AACTTTATTG ATTTAGGCAT GGATCCATCT AGTTTAATTA ATATATTGGG TATGAGGAAG CTACTTGCTG TACTTTCCAT GTGGTTCTCT CTCCCTGGAG AGGAACATTT TTACTCAGCT TGCAAACTGG AAATAGATTT TCTCACATTA GAAGCTCATT TTCTGGGTAT GAGACAGGAG AGTTCATACT GTGTATGTAG ATCTCTGGCT TCTGGGTCTG ACATGTGCTG AGGGACACAT ATCCTTCACA CATGCTTTTA TAAATACTTG ATAAAGTAAC CTGCTTCTTG ATTGGTCTTT ATAATCCATA AGCTGTGGGA TGCTTCTCTG EPI-109 35

AAGATGAAAA TAGTAATAGA GTCCCATCTA GCTATTCAAA GCCATTCCTT CATTGTATTC TGTGCACATG AAGTTGGGGT TTGTTACTGA CAAAATATAT TCAGATACAT TTCTATGTTA AAAGGATTGT GAGATGCATA GGTAAATGTG TTTATTTTCA GTTTTACTTG TCAACATAGA TGAATGAGAA AGAACTTGAA AGTAACACTG GATTAAGAAT AGGAAAATTT GGCATGGATT TTGCTCCATT TTGTCCCATC TAATCACTTG GATAGTGTTC AGGTGTTCTT GGTCAGTTAC TTGGATGCTC TGAGCTTTAG TTTCTTGGTG ATTACAATGA AGATTTGAAT TACAGGATGG CTTTGAAAAA ATAAACAAAA CTCCCCTTTC TGTCTGTCGA GAATGTTGCA CAGGGAGTTA CAGAATGTTC TCATGACTGA ATTGCTTTTA AATTTCACAG TGTGCCTGCA TTTGAAGTCT TGGAAATATC TCCCCAGGAA GTATCTTCAG GCAGACTATT GAAGTCGGCC TCATCCCCAC CACTGCATAC ATGGCTGACA GTTTTGAAAA AAGAGCAGGA GTTCCTGGGG GTGAGTGAGC CTCCTCCAAC TTTGACTAGA GTAAGGGTTG GGTCTAGAAA AGAATATTGA GTTGCATCAA CTGTTTTCCC ACTTGGATTC ATGAGAGGTG TTAGGTCCTT TAAAAAACAT GGTAGATAAA GAGTTGACAC TAACTGGGTC CTTTTGGGAA GAGCCAGAAG CATTTCCTCA TAAAGACTTT AAATTGCTAG GACGAGAATG GCCAACAGGA GTGAAGGATT CATAACTTTA TCTTTACTTA GATGTAAAGA ACAATTACTG ATGTTCAACA TGACTACATA CATAAAGGCG CATGGAGAAA AGTATTGGCC TTCCATGCAT TAGGTAGTGC TTGTATCAAT TCTTATAGTG GCTAGGGTAT CCTGGAAAAT CTTACGTGTG GATCATTTCT CAGGACAGTC TAGGACACTA ACGCAGTTTC TCATGTTTGG CTTCTATTAT TAAAAAATGA TACAATCTCG GGAAAATTTT TTTGATTTTC ATGAAATTCA TGTGTTTTTC TATAGGTAAC ACAAATTCTG ACTGCTATGA TATGCCTTTG TTTTGGAACA GTTGTCTGCT CTGTACTTGA TATTTCACAC ATTGAGGGAG ACATTTTTTC ATCATTTAAA GCAGGTTATC CATTCTGGGG AGCCATATTT GTGAGTATAT ATCTATAATT GTTTCTGAAA TAACACTGAA CATAGGTTTT TCTCTTTCTC AGATCTAACC AGTTGTTTAT TCCCAGTATT AAGATGATAT TTATAATTCT TAATTATAAA TATATGTGAG CATATATAAC ATAGATATGC TCATTAACAA CAACAAAAGA TTCTTTTTAC AATTAACGGT GGGTTAAACA TTTAGCCCAC AGTTTTATCC CATGAGAAAC CTGAATCTAA TACAAGTTAA ATGACTTGCC TAAGGGCCAC TTGACTAATA GTAATTGAAC CTAAACTTTC AGAATCCAAC TCCAGGAACA TACTTCTAGC ACTATTCATC AATAAAGTTA TATGATAAAT ACATACAACT TTATCTGTCA ACTAAAAATA ACAACAGAGG CTGGGCATGG TGGCTCACAC CCGTAATCCC AGCACTTTGG GAGGCTGAGG CAGGTGGATC ACCTGAGGTC AGGAGTTTGA GACCAGCCTG ACCAACATGG TGAAACCTCA TCTCTACTAA ATATAAAAAA TTAGCTGAGT GTGATAGTGC ATACCTGTAA TCCAGCTACT TAAGAGGCTG AGGCAGGAGG CTTGTTTGAA CCTGGAAGGC AGAGGTTGCA GTGAGCTGAG ATTGTGCCAT TGCACTCCAG CCTGGGCAAT AAGTGCGAAC TCTGTCTCAA AATAATAATA ATAATAATAG AAAATAAAGT TGTCTTCATG AAAAATGAGG AAAGAGATTG CTGGGGTGAG AAACATTAAG ATCAATGGGC ATATGGTGAC CTTCTATGCC CTAGAAACTC TTTTANGGTA TTTTCTCCTG GTATCTCTTT TACNCATCGT TCTATCTGGA AAAATAGGTG GATGAGTGAG ATAATAACGG TATATACTTT TTAAAGGTCT AATTGACATA TATAAATTGC AAGTATTTCA GATGTCAATT TGCTAACCTT GACACACATA GACACACATG AAAACATCAC CACATTAATA CAATGTATGT ATCCATCATT CCAAAAGCTT CCCTGTGTAT CTTTGTAACT CTTTCTTCCT CCCTCCACTC CTTGTCCTCT CGTTCCCAAG AAAACATTGA TCTGCTTCCT GTGAATATAA ATTAACTTAC ATTTTTTAGA GCTTTATATA AGTATGTTCT CTTTACTGTT TGTCTTCCTT CGCTGCACAG TTATTTTGAG ATTCTTCAAG TTTTTTCTTT ATATCGATAC TTCATTCACA AGAATATATT TTAATTCTAG ACTATGTCAC ATTGACTTTG TCGTCTGCTA AATCCTTAGT GCTCAGATGA CTTGTTCAGG ACTCTCCTTG AACCTGTACC TCTGTTANAT TGAAACTTGT CTCTACTGTC TTTTTATTTC AAACACAGCT TATTAGGTGT CTCTCAACCC ATCAAACNCA CAATCTGAGT CTTTAGGAGA TTGCTTTGAA TTTGTGCTAT TGACTTATAT NTATATNAAA TNTGTAAATG TTTGGTAAAA ATATCATCAT GTACNTTTTC ATAATTACGC TATNTNCACA TGATATATGT CAGACTCTGG AAATATGCAT GCCACAGACA CGTGTTTCTT GCCTAAAGGG GCTGATGGAA GACNCACATA CNAATAGACG ATTGCAGTAG AATGAGAGTG GTGGTCTAAN CAGTACATGT CCTGATGTTG CTCGGACAGT TACTACNCCA AGAGTACCCC CTGCATTGTC AGGGTTAGCA TCTCCTGGAA GCCTCATGTA AATGAAGAAT TTCATGCTCC ATCCAGGACC TAATGAATAA GAATCTGCAT TTTAGCAAGA CCCTCATATG ATTCATATAC ACTrrTTTTT TTTTTTTTTA GATGGAGTCT CACTCTTGTC GCCCAGGCTG GAGTGCAATG GCATGATCTT GGCTCACTGC AACCTCTGCC TCCCGGGTTC AAGTGATTCT CCTGTCTCAG CCTCCCTAGT AGCTGGGACT ACAGGTGCAT GCCACAGTGG CTGGCTAATT TTTGTATTTT TAGTAGAGAC AGGGTTTCAC CATTTTGGTC AGGCTGGTCT TGAACTCATG ACCTCCGGTG ATTCCCCCGC CTCGGCTTCC CAAAGTGCTG GGATTACAGA CATGAGCCAC CACACCCGCC TTATTCGTAT ACNCATTTAA TTCTGAGAAG CACTCTATAG AAAATAAGAA TAAGAAAATA TTGGGCTCAC AGGTGACATT AATAAGTAAC TTTATCGAGT ACCCCAAATT TTACCTATGT TTGGAAGATG GGGTTAAAAG GACACATTGA AAACAAGAAC TCATTGTGGC TTTTTTTTCC TCCTTTTTGA ACAGTTTTCT ATTTCTGGAA TGTTGTCAAT TATATCTGAA AGGAGAAATG CAACATATCT GGTGAGTTGC CCGTTTCTGT CTTTGTCCAT CCTTGAAAAG ATAAGAAGAA CAGAGTTTTA AGAGTCTTAA GGGAAACACA TCTTTGTCTC CTATATTACT TGTGAATGTG GATATATGAT TTTGTTTCAA TCTATTTTGT GTCCTAAGGC TTTTTGCAAC AGAAGTTGGA TATATCATTA GAAACATAAA TTGTACCATT TAACATACAT GAAGTTTATG TTTACCTTGA CGTTCTTCTA AAAAGTGTCC TACACCGGCA TTGTCCTTGT AGGCATATTC ACATGATCAA ATAAAATAAT TAGTTTTCAA TTAAGGAGAA TATTTGAGGA AAGACCGTAC GTGTTCATGT GGTTCCTGAA GGCAGTCCAG TGAGAAAGTA ATATATGCTT CATTAAACAA TGCGGACATT TTCAGGGTTT CCCTTTTTAA CCAAAATTTG GAAGCAATGT GGAATTTACT GGATGCATCC AGCCCTGAAA TGAAGATAGG TTTATTGAAT GTGCCAGCAA GTGCAGGCCC AGGTCTGAGT GTTCTTCATT ATTATCAGGT GAGAGGAAGC CTGGGAGCAA ACACTGCCAG CAGCATAGCT GGGGGAACGG GAATTACCAT CCTGATCATC AACCTGAAGA AGAGCTTGGC CTATATCCAC ATCCACAGTT GCCAGAAATT TTTTGAGACC AAGTGCTTTA TGGCTTCCTT TTCCACTGTA TGTATTTTTT TTTGTGTGGG AAGACTAAGA TTCTGGGTCC TAATGTAAGT AAGAAGCCCT CTTCTCCTGT TCCATGAACA CCATCCTTTT CTGTAACTTC TATTACACAG TATAGTGGTT CTGTAAGTTC ACACAGCCCA GGGAGATGCT GGCTGCCCAC TCCCCTCAAC CCAGGCAAAT TCCTCGGGGT TAAAGTTATC TACTGCAAGT GACGATCTCT GGGTTTTTCT GTGCCTGTGT TTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTATGTGTCA CTTTAAAAGG ACTGGTCAGA TGGTAGGGAG ATGAAAACAG GAGATGCTAT AAGAAAATAA ACTTTTGGGG CGAATACCAA TGTGACTCTT TTTGTTTGTC ATTTGTTGCT GTTCAATAGG EPI-109 36

AAATTGTAGT GATGATGCTG TTTCTCACCA TTCTGGGACT TGGTAGTGCT GTGTCACTCA CAATCTGTGG AGCTGGGGAA GAACTCAAAG GAAACAAGGT AGATAGAAGC CCGATATAAA ATCTTGAATG ACAGGTTAAC GAATTGGAGC TTTATTCCTT AAAATATGGC CTGGGTTTTC TGAAACATTT CTTCCAGAAA ATAGTTTCTC CAAGTTTTAT TACTTTGGTT TACAAATCTC ACATTTAAAT CACATTTTAT ACCATAAGTA GCACACATTT CATAATATTC CTCTGAATGA GGGTTGGGAT AATAGGACTG ATATGTTAGA AATGCCTTAA AGTGTGTGGA GCATGAGAGA TGGATGTACA GAAGGCTTGT GAGGAAACCA CCCAGGTATC TGGCCTTGTT TTCTGCCCCA GAACTAGCCG CCTATTCCTG TTTCTGTTTT ATTCCTTTGT TTCTTGACTT TTCCTTTCCA ACTTGCTCTA AAACCTCAGT TTTCTTTCCT TTCTGATTCA TGACTACCAA ATGTTTTCAC TTGCCTCACC CGTCCATTAC ACCTTTGATA AGAACCACCA GACCTTGTGC TCATGTACTT GCCCATGTCT GATGGAAGAA ACATACTCTC TCCATCTGTC CACTTTCCTG AGGCATTCAA GTCTAGCCAC CTTTTAAAAT CACTCTCCTC CAGGCTGGGC ACGGTGTCAC GCCTGTAATC TCAGCACTTT GTGAGGCTGA GGAGGGCGGA TCACTTGAAG TCAGGAGTTC AAAACCAGCC TGGCCAAATG GCAAAACCAA ATCTTCTTCA ATTATAACCA AATCTTAAAC CAAATCTCTA CTAAAAAATA CAACAAAACA AAACAACAAC AACAAAAACA GAAAAGGAAA CATTAGCCCA GCGTGGTGGC AGGTACCTGA GGTTCCAGAT ACTTGGGAGG CTGAAGCAGG AGAATCGCTT GAGCCCAAGA GATGGAGGTT GCAGTGAGCC GAGATCATGC CACTGCACCA CAGCCAGGGT GACAGAGCCA TACTTCCCAG CACATTGGGA GGCCAAAGCT GAAGAATAAT TTGAGGTGAG GATTTGGAGA CCAGCCTGGC CAACATGGTG AAACTCCGTC TGTACTAAAA ATATAAAACT TAGTGGGGCA TGGGGGCACA CACCTGTAAT TTCAGCTACT TAGGAGGCTG AGGCAGGAGA ATTGCTTGAA CCCGGGAGGC GGAAGTTGCA GTGAGCCAAG ATCGTGGCCA CTGCACTCCA GCCTGGGTGA CATAGTGAGA TTCTGTCTCA AAAAAAATAA AAGAAATTTA AAAAATCACT CTCTTCCAAA GATAGATAAA TAAGACAGCA GATATACTAA GGAATAACCT CACCAACTTG TCATTGACTG ACATGATTTC TTTTGGCCCA CTTGGCCAGC TAGTCTGGTT TGGTTTTCTG GAAATGAAAG AAATAATCAG AGTTTAATGA CAGAGAGCGT GAGACCCAGA AAGACAAAAG TAGATGAGGT AAGTCTCTTG AGCGAGACTT CTAGGGATGG GAAATTTGTG GTGATTGATA TGAAATGATT TTTCCCTTAT CAGGTTCCAG AGGATCGTGT TTATGAAGAA TTAAACATAT ATTCAGCTAC TTACAGTGAG TTGGAAGACC CAGGGGAAAT GTCTCCTCCC ATTGATTTAT AAGAATCACG TGTCCAGAAC ACTCTGATTC ACAGCCAAGG ATCCAGAAGG CCAAGGTTTT GTTAAGGGGC TACTGGAAAA ATTTCTATTC TCTCCACAGC CTGCTGGTTT TACATTAGAT TTATTCGCCT GATAAGAATA TTTTGTTTCT GCTGCTTCTG TCCACCTTAA TATGCTCCTT CTATTTGTAG ATATGATAGA CTCCTATTTT TCTTGTTTTA TATTATGACC ACACACATCT CTGCTGGAAA GTCAACATGT AGTAAGCAAG ATTTAACTGT TTGATTATAA CTGTGCAAAT ACAGAAAAAA AGAAGGCTGG CTGAAAGTTG AGTTAAACTT TGACAGTTTG ATAATATTTG GTTCTTAGGG TTTTTTTTTT TTTTAGCATT CTTAATAGTT ACAGTTGGGC ATGATTTGTA CCATCCACCC ATACCCACAC AGTCACAGTC ACACACACAT ATGTATTACT TACACTATAT ATAACTTCCT ATGCAAATAT TTTACCACCA GTCAATAATA CATTTTTGCC AAGACATGAA GTTTTATAAA GATCTGTATA ATTGCCTGAA TCACCAGCAC ATTCACTGAC ATGATATTAT TTGCAGATTG ACAAGTAGGA AGTGGGGAAC TTTTATTAAG TTACTCGTTG TCTGGGGAGG TAAATAGGTT AAAAACAGGG AAATTATAAG TGCAGAGATT AACATTTCAC AAATGTTTAG TGAAACATTT GTGAAAAAAG AAGACTAAAT TAAGACCTGA GCTGAAATAA AGTGACGTGG AAATGGAAAT AATGGTTATA TCTAAAACAT GTAGAAAAAG AGTAACTGGT AGATTTTGTT AACAAATTAA AGAATAAAGT TAGACAAGCA ACTGGTTGAC TAATACATTA AGCGTTTGAG TCTAAGATGA AAGGAGAACA CTGGTTATGT TGATAGAATG ATAAAAAGGG TCGGGCGCGG AGGCTCACGC CTGTAATCCC AGCCCTTTGG GAGGCCGAGG TGGGCAGATC ACGAAGTCAG TAGTTTGAGA CCAGCCTGGC CAACATAGTG AAACCCCGTC TCTACTAAAA ATACAAAAAA AAAATTAGCT GGGTGTGGTG GCAGTCACCT GTAGTCCCAG CTACTTGGGA GGATGAGGCA GGAGAATCGC TTGAACCTGG GAGGCGGAGG TTGCAGTGAG CCGAGATCGC ACCAGTGCAC TCCAGCCTTG GTGACAATGG GAGACTCCAT CTCAAAAAAA AAAAAAAAAA AAAAAAGATA AAAAGTCAGA AATCTGAAAA GTGGAGGAAG AGTACAAATA GACCTAAATT AAGTCTCATT TTTTGGCTTT GATTTTGGGG AGACAAAGGG AAATGCAGCC ATAGAGGGCC TGATGACATC CAATACATGA GTTCTGGTAA AGATAAAATT TGATACACGG TTTGGTGTCA TTATAAGAGA AATCATTATT AAATGAAGCA AGTTAACACT CTAAGAGAAT TATTTTGAGA TAGAAGTGAA GCTAAGCTAA ACTTCACATG CCTATAATTG GAGGGAAAAA CTAAGGATAA AATCTAGCCT AGAAGATACA ATAATTAGTC ATAAACATGC ATTGTGAAAC TGTAGAGAGC AGGTAGCCCA AAATAGAGAA AGATTAGATA AAGAGAAAAT AAGTATCCAT CAGAGACAGT ATCTCTAGGC TTGGGCAAGA GAAAAGTCCA CAGTGATAAG CAACTCCACC TAAGGCATGA ATATGCGGCA GAGAAAACAG CAATAGTGAA TGAATGCAAA AGGTGCTGAG CAAATTCCAC ACATGAGTAT TGTGCATGAG TAAATGAATA AAACATTTGC AAAGACCTTT AGAGAAAGAG AATGGGAGCA TATGTGCGAA ATAAGATAGT TGATTATGAA TAGAAGGTAG TGAAGAAAAG CAAGCTAAGA AAAAATTCTG TTTATAAAAG AAGGAAAAGA TAGTTTATGT TTTTAGCCTA AGTATAAGAG TCCTACAGAT GGACTGAAAA AAATCAGTCT GAGAGTATTA GTCACAATTA ATGAAATAAT TACATTTTAT GTATTGAGGA TGCCAAGATT AAAAGGTGAC AGGTAGATGT TAATTTCCCT AGATTGTGAA AGTGATCACG ACAATCACAC AACAAATAAT TAAGTGACTT GGTATGCTTT ATTTAATTGT AGGGCCTGAG GTTTTCCATT CTCATTTTTC TAAAATACAA TTTTGTTTCT CCAAATTTGA CAGCAGAATA AAAACCCTAC CCTTTCACTG TGTATCATGC TAAGCTGCAT CTCTACTCTT GATCATCTGT AGGTATTAAT CACATCACTT CCATGGCATG GATGTTCACA TACAGACTCT TAACCCTGGT TTACCAGGAC CTCTAGGAGT GGATCCAATC TATATCTTTA CAGTTGTATA GTATATGATA TCTCTTTTAT TTCACTCAAT TTATATTTTC ATCATTGACT ACATATTTCT TATACACAAC ACACAATTTA TGAATTTTTT CTCAAGATCA TTCTGAGAGT TGCCCCACCC TACCTGCCTT TTATAGTACG CCCACCTCAG GCAGACACAG AGCACAATGC TGGGGTTCTC TTCACACTAT CACTGCCCCA AATTGTCTTT CTAAATTTCA ACTTCAATGT CATCTTCTCC ATGAAGACCA CTGAATGAAC ACCTTTTCAT CCAGCCTTAA TTTCTTGCTC CATAACTACT CTATCCCACG ATGCAGTATT GTATCATTAA TTATTAGTGT GCTTGTGACC TCCTTATGTA TTCTCAATTA CCTGTATTTG TGCAATAAAT TGGAATAATG TAACTTGATT TCTTATCTGT GTTTGTGTTG GCATGCAAGA TTTAGGTACT TATCAAGATA ATGGGGAATT AAGGCATCAA TAAAATGATG CCAAAGACCA AGAGCAGTTT CTGAAGTCCT CCTTTTCATC AGCTCTTTAT CAAACAGAAC ACTCTATAAA CAACCCATAG CCAGAAAACA GGATGTAGGA ACAATCACCA GCACACTCTA TAAACAACCC ATAGCCAGAA EPI-109 37

AACAGAATGT AAGGACAATC ACCAGCCATC TTTTGTCAAT AATTGATGGA ATAGAGTTGA AAGGAACTGG AGCATGAGTC ATATTTGACC AGTCAGTCCT CACTCTTATT TACTTGCTAT GTAAACTTGA GAAAGCTTTT TTCTCTTTGT GAACCTCAGG TTTTACATCT GAAAATGAGA AATTTGGAAC AAAAGATTCC TAACTGGTCT TTCTGTTCCC ATATTCTGTG ATTTTTCAAT ATTTAGGATT TTTGGTAATC ACAATTACTT AGTTTGTGGT TGAGATAGCA ACACGAATCA GAACTATTTG GTGGACATAT TTTCAAAGGA GTAGCTCTCC ACTTTGGGTA AAGAAGTGAT GCNGGTCGTG GTGGCTCACG CCTGTAATCC CAGCACTTTA GGGAGGCCAA GGCGGGTGGA TCACGAGGTC AGGAGATCGA GACCATCCTG GCTAACACGG TGAAACCCCG TCTCTACTAA AAAATACAAA AAATTAGCCA GGCGTGGTGG CGGGCGCCTG TAGTCCCACG TACTCGGGAG GCTGAGGCAG GAGAATGGCA TGAACCAGGG AGGCGGAGCT TGCCGTGAGC CGAGATAGCG CCACTGCAGT CCCTCCTGGG CAAAAGAGCA AGACTGCGTC TCAAAAAAAA AAAAAAAAAA AAAAAAAGAA GTGTGTGGAG TAGCAGGACA CCTGCAACAA TAATATTTTT CTAAATCCCT CTGAAAAATG CTAATCAAAG GGTTTTTTTC CTAAAAATTG TCTTAGAAAT AAAATTTCCC CTTTGGGAGA CCGAGGCTGG CAGATCACGA GGTCAGGAGA TAGAGACCAC GGTGAAACCC CGTCTCTACT AAAAATACTA AAAATTAGCC GGGGNGTGGT GGTGGGTACA CCTGTAGTCC CAGCTACTTG GAGGCTGAGG CTGGAGAATC ACGTGAAC GCCACGTGCT GCTGGGTCTC AGTCCTCCAC TTCCCGTGTC CTCTGGAAGT TGTCAGGAGC AATGTTGCGC TTGTACGTGT TGGTAATGGG AGTTTCTGCC TTCACCCTTC AGCCTGCGGC ACACACAGGG GCTGCCAGAA GCTGCCGGTT TCGTGGGAGG CATTACAAGC GGGAGTTCAG GCTGGAAGGG GAGCCTGTAG CCCTGAGGTG CCCCCAGGTG CCCTACTGGT TGTGGGCCTC TGTCAGCCCC CGCATCAACC TGACATGGCA TAAAAATGAC TCTGCTAGGA CGGTCCCAGG AGAAGAAGAG ACACGGATGT GGGCCCAGGA CGGTGCTCTG TGGCTTCTGC CAGCCTTGCA GGAGGACTCT GGCACCTACG TCTGCACTAC TAGAAATGCT TCTTACTGTG ACAAAATGTC CATTGAGCTC AGAGTTTTTG AGAATACAGA TGCTTTCCTG CCGTTCATCT CATACCCGCA AATTTTAACC TTGTCAACCT CTGGGGTATT AGTATGCCCT GACCTGAGTG AATTCACCCG TGACAAAACT GACGTGAAGA TTCAATGGTA CAAGGATTCT CTTCTTTTGG ATAAAGACAA TGAGAAATTT CTAAGTGTGA GGGGGACCAC TCACTTACTC GTACACGATG TGGCCCTGGA AGATGCTGGC TATTACCGCT GTGTCCTGAC ATTTGCCCAT GAAGGCCAGC AATACAACAT CACTAGGAGT ATTGAGCTAC GCATCAAGAA AAAAAAAGAA GAGACCATTC CTGTGATCAT TTCCCCCCTC AAGACCATAT CAGCTTCTCT GGGGTCAAGA CTGACAATCC CGTGTAAGGT GTTTCTGGGA ACCGGCACAC CCTTAACCAC CATGCTGTGG TGGACGGCCA ATGACACCCA CATAGAGAGC GCCTACCCGG GAGGCCGCGT GACCGAGGGG CCACGCCAGG AATATTCAGA AAATAATGAG AACTACATTG AAGTGCCATT GATTTTTGAT CCTGTCACAA GAGAGGATTT GCACATGGAT TTTAAATGTG TTGTCCATAA TACCCTGAGT TTTCAGACAC TACGCACCAC AGTCAAGGAA GCCTCCTCCA CGTTCTCCTG GGGCATTGTG CTGGCCCCAC TTTCACTGGC CTTCTTGGTT TTGGGGGGAA TATGGATGCA CAGACGGTGC AAACACAGAA CTGGAAAAGC AGATGGTCTG ACTGTGCTAT GGCCTCATCA TCAAGACTTT CAATCCTATC CCAAGTGAAA TAAATGGAAT GAAATAATTC AAACACAAAA AAAAAAAAAA AAAAAAAA GCCGGAGCCG ACTCGGAGCG CGCGGCGCGG CCGGGAGGAG CCGAGCGCGC CGGGCGCGGC GTGGGGGCGC CGGCTGCCCC GCGCGCCCAG GGAGCGGCAG GAATGTGACA ATCGCGCGCC CGCACCGTAG CACTCCTCGC TCGGCTCCTA GGGCTCTCGC CCTCTGAGCT GAGCCGGGTT CCGCCCGGGC TGGGATCCCA TCACCCTCCA CGGCCGTCCG TCCAGGTAGA CGCACCCTCT GAAGATGGTG ACTCCCTCCT GAGAAGCTGG ACCCCTTGGT AAAAGACAAG GCCTTCTCCA AGAAGAATAT GAAAGTGTTA CTCAGACTTA TTTGTTTCAT AGCTCTACTG ATTTCTTCTC TGGAGGCTGA TAAATGCAAG GAACGTGAAG AAAAAATAAT TTTAGTGTCA TCTGCAAATG AAATTGATGT TCGTCCCTGT CCTCTTAACC CAAATGAACA CAAAGGCACT ATAACTTGGT ATAAAGATGA CAGCAAGACA CCTGTATCTA CAGAACAAGC CTCCAGGATT CATCAACACA AAGAGAAACT TTGGTTTGTT CCTGCTAAGG TGGAGGATTC AGGACATTAC TATTGCGTGG TAAGAAATTC ATCTTACTGC CTCAGAATTA AAATAAGTGC AAAATTTGTG GAGAATGAGC CTAACTTATG TTATAATGCA CAAGCCATAT TTAAGCAGAA ACTACCCGTT GCAGGAGACG GAGGACTTGT GTGCCCTTAT ATGGAGTTTT TTAAAAATGA AAATAATGAG TTACCTAAAT TACAGTGGTA TAAGGATTGC AAACCTCTAC TTCTTGACAA TATACACTTT AGTGGAGTCA AAGATAGGCT CATCGTGATG AATGTGGCTG AAAAGCATAG AGGGAACTAT ACTTGTCATG CATCCTACAC ATACTTGGGC AAGCAATATC CTATTACCCG GGTAATAGAA TTTATTACTC TAGAGGAAAA CAAACCCACA AGGCCTGTGA TTGTGAGCCC AGCTAATGAG ACAATGGAAG TAGACTTGGG ATCCCAGATA CAATTGATCT GTAATGTCAC CGGCCAGTTG AGTGACATTG CTTACTGGAA GTGGAATGGG TCAGTAATTG ATGAAGATGA CCCAGTGCTA GGGGAAGACT ATTACAGTGT GGAAAATCCT GCAAACAAAA GAAGGAGTAC CCTCATCACA GTGCTTAATA TATCGGAAAT TGAAAGTAGA TTTTATAAAC ATCCATTTAC CTGTTTTGCC AAGAATACAC ATGGTATAGA TGCAGCATAT ATCCAGTTAA TATATCCAGT CACTAATTTC CAGAAGCACA TGATTGGTAT ATGTGTCACG TTGACAGTCA TAATTGTGTG TTCTGTTTTC ATCTATAAAA TCTTCAAGAT TGACATTGTG CTTTGGTACA GGGATTCCTG CTATGATTTT CTCCCAATAA AAGCTTCAGA TGGAAAGACC TATGACGCAT ATATACTGTA TCCAAAGACT GTTGGGGAAG GGTCTACCTC TGACTGTGAT ATTTTTGTGT TTAAAGTCTT GCCTGAGGTC TTGGAAAAAC AGTGTGGATA TAAGCTGTTC ATTTATGGAA GGGATGACTA CGTTGGGGAA GACATTGTTG AGGTCATTAA TGAAAACGTA AAGAAAAGCA GAAGACTGAT TATCATTTTA GTCAGAGAAA CATCAGGCTT CAGCTGGCTG GGTGGTTCAT CTGAAGAGCA AATAGCCATG TATAATGCTC TTGTTCAGGA TGGAATTAAA GTTGTCCTGC TTGAGCTGGA GAAAATCCAA GACTATGAGA AAATGCCAGA ATCGATTAAA TTCATTAAGC AGAAACATGG GGCTATCCGC TGGTCAGGGG ACTTTACACA GGGACCACAG TCTGCAAAGA CAAGGTTCTG GAAGAATGTC AGGTACCACA TGCCAGTCCA GCGACGGTCA CCTTCATCTA AACACCAGTT ACTGTCACCA GCCACTAAGG AGAAACTGCA AAGAGAGGCT CACGTGCCTC TCGGGTAGCA TGGAGAAGTT GCCAAGAGTT CTTTAGGTGC CTCCTGTCTT ATGGCGTTGC AGGCCAGGTT ATGCCTCATG CTGACTTGCA GAGTTCATGG AATGTAACTA TATCATCCTT TATCCCTGAG GTCACCAGGA ATCAGG-3'(SEQ.ID Nθ:2409)

Human Enzvme-related Antisense Polynucleotide

₅'-CTT GCT CCT GGG GGC CTC CTG GTC CCT CTG GCT G TT CCC GGC CCT GGB CTG GGG CBG GGG CCG CGT BGG CGC EPI-109 38

GGC TCG CCB GGB CGG GCB GCG CCB GCB GCB GCB GGC TCB GCB TCC TGG CCB CGG BBT TCC GGT GTG CGG GGC CTG GTG CC CCT GGG CCT CGG GTG CTG CCT GT GCG CTG CCT TCT TCT CCT GG GTC CTC GCC GGG GCC CTT GCT GCC CTG GCT GT GCC CTG GGG GTC TGG GTT CGG CTG T CCC CBG CBG GBC CBG TCC CBT CCB CBG CGT GTG BTG BGT BGC CBT TCT CCT GCB GCC GBG GGG CGC GGG CGB GCB TCG C TTT GGG CTT TTC TCC TTT GGT T TGB GCG CCB GGB CCG CGC BCB GCB GCB GGG CGC GGG CGB GCB TCG CBG CGG CGG GCB GGG GGGCTCCCGC CGCGBGBGGT TBTGGGCTCC CBGGBCCBCC CGCBCCGCGC GGBCGTTTBC BTTCGCCBCG CBGTGCGCGG CCGBCBTGBC GBBGTTGGGC GCBBTCBGGG TGGCGCCGCB GBBGTGGCCT CCGCGCBGCT GCBGGGBCBC CBTGBBGGGC CBCGCGTGGG GCCGCGCTCG CCGGCCCCCC BCBBTCTCCG BGGCCBGCGC GGTGCCCCCC BGCBGCBBGG CCGGCBGGBC BCBGGCGBGG BGBCBCGCGB GTCGGCGGCC GBGGGTCBTG GTGGGGCTGG GGCTCCGGGG TCTCTGCCCC TCCGTGCTGG TGGGGCTGGG GCTCCGGGG TCTCTGCCCC TCCGTGCCGC GTGGGGCCGC GCTCGCCGGC CCCCCCCTGC CGGGTGGGCT CCCGCCGCGC GCCGGCCTGC CGGCCCCTCG TGGGTCCTGC TGGCCGGGTC CGGGTCCCGG GGGTGGGGCG CGBGTCGGCG GCCGBGGGTC CCCTCCBCBT CTGCTCTGBC CTGCTGGBCT CTGGBTCTGB BGBTBCGCCB TGTBGGGGCG GGBGTGGGGC CTGCTCTCCC GGCCTCCGBT GBTCTCCCCT GCCTCBGCCC CBGTGGGTBG GBGBBBGGCC BGCBGBBGCB GGBGTGGCTG CBTCTTTCCT GGTGGGGCCT GCTCTCCCGG CCTCCGTGTG TTGCTGGGTG TTTTCCCGTC TCTGGTCTGC CTTCGGGGGT CGT CCGGGGCTGC BGCBBCCTCB TCBGCTCTTG CCTGGBGTGG CTCBGCCTGG GCCTGCBGGG CCBCCBGGBG BBTGGCBGCB BGGBTGGCGB GGGTCCTCBT GGCTGGGGTC BCBGBTCCTC TBGCTBGGCB GGGTGBCCBG BGBGGGC GGG TCC TCB TGG CTG GGG GCC TGG GCC TGC BGG GCC GCT CTT GCC TGG BGT GGC TC GCC CBG BGT CTT CCC TGG T CGCTGCBBTC TGCTCCGGGG CTGCBGCBBC CTCBTCBGCTC TTGCCTGGBGTG GCTCBGCCTGG GCCTGCBGGG CCBCCBGGBGB BTGGCBGCBBG GBTGGCGBGGG TCCTCBTGGC TGGGGTCBCCT GGBGGBGGGB GBGCBGGGGG TCCTCBTGGC TGGGGTCCCT CTCTCCCGTC CT CGG TTT CCT TTG CGG TC TTG GCC CGG GCT CCG GGT G CCC GCC CGC CCG CCG GCC GCC GC CCC GCC GGG CTG TCC CCG CCC CGC CCC GGC CCG GGG CGC GGG GG CGG CCC TCC CGC CCC TCT GG GCC GGC GCG GGC GTC GG CCG CTC GCG CCT GGG GTT CCC TCT CCT CCC CCT GTG C GCC TGC CTC TTG CTC TTCTGC GTC CGC TGC CTT CTC CC CTC TCC TCG GCC GTT GCC TGT GC TGT CCG TCC TGT CGC CCT TCC GTG GTG C TGT TGT CTC TTC TGC CCT C GGT GTG CTG GTG CTG GTG GTG GTG CCT CTG CCC GTG CTC GCCCTG CCT GGG CTG GCC TCT TCG GGT GTG GCT TTG GGG CTC TCT TGG TTG CCC TTT CTT CTC GTG GTG CCT CTC CTC CCT GGC TTG GTC GT TGT CTG GGG TGG TGC TCC TCT CCC TTT CCC TGC TGG CCG TTT GT CCT GTT TTC TGT CTT CCT CT TTC CTC CTG TTT CTC CGT TTG GCT TGC TGC TTG CGG GGC TGT CTC C CTT GCC CCT GTG GGC TTT CCC TGG TCC GGT CTT CTC CTT GGG GGT C GCC CTT CTT GGT GGG CTGGCT CGT CTG TCT TTT TCC TTC C TGG GGG TGG CCG TTG TGG GCG GTG TGG TCC GCC T TGC CTC TGC TGG TCT TTC CTCGGTBGBC GCGCTCGBBC TCGGGTGGGC CGGTGGTGBG CGGCGGCGBCB CGCGGBBGGC CCTGCGCGCC GBGBTCBCCTG CBGGGBGBBG TBGGCTTGCB GCBGGBCTCC CBGGBGGGTG BCBGCBGCCB GTBGBGCTBC CTCGTCCTTC BTGGTBCCGT CGGTGTGGTG GCBCGGGCTG TGTGTGBBGG CGBGCTGGGC CCCGTCTGCT GCTCCTCGTG CCGCCTCGTC CTTCA TGG TA CCGTCGGTGT GGTGGCCTCG GGTGGGCCGG TGGTGGGGCG CGCGCGCTCG CGTGGCTCCG GCTCTTCTTT CCCGGCTCCGT CGGCCCGGGG GCCTTGGTCT CCCTCGTCCT TCBTGGTBCC G BCCGGCGGBG CCGCCBGGGT GGBCTGGGBG TGGGTTTCTC CCCGCCGTTC TCBCCCBCCG CGCTGBGCTC BGCGCCTBBG BCTGCTGTTT CTGGBGCTCC TTGGCBBGCC BCBBBCBGCB GBGBGBBBBT CBTGBGCBBB TBBTCCBTTC TGBBBBBBBG GGBTCBBBBB CCTCCCGTTC CCCGTTCGCC TGGCGCGCGC TGCGGGTTCC TCGTGGGTTT CTCCCCGCCG TTCTCCGGTC TGTTGCCTTT GTGGGCTTCT TGTCTTTTTG GCTGTTCTTT TCCTGCTTGG CGTCTTTTCC TTTCTTTGTG CTCGGTTGTG GGTCCGCTGG TCCTTTGCCC TGTGTGTTTC TGCTGCCCGT TCGCCTGGCG CGCGCTGCGG GTTCCTCGTG GGTTTCTCCC CGCCGTTCTC CGGTCTGTTG CCTTTGTGGG CTTCTTGTCT TTTTGGCTGT TCTTTTCCTG CTTGGCGTCT TTTCCTTTCT TTGTGCTCGG TTGTGGGTCC GCTGGTCCTT TGCCCTGTGT GTTTCTGCTG GGBGCTGBTB CTGCBGATTT CBGBGGGBBG BBCCCTGBTB CTCBCCBGCT TCBGCTCTGG BGCBCBBGBG BBBGBGCBGC BGGGGGBGBG GBBGBBGCBG CBTCTTCCCB GBGBGGCTGC CTGBGCBBBT GCTGGTTTTC CTTTCCBGTC TTGGGTTTTB TBBCTCCCBG BBGGCBBGBG BGGGGCBBGG CGTTTTCTTC TCTCGCTGGT TTTCCTTTCC TGGCAGTGGG TGGGGGTGGG GGTGGGGTGG CTTCCTTGTT CCTGGGGGTG TCCTCTTGCT CTGGGCTTTT CTCCCCTTTT CCTTCCTGTC TGTTTTCCTG GGGCTCTCCT CTGTCTCTGT GTCCTTGCCC TGGCCCTCTT CCCTCTCCTG TCTCCTGTCC CTGTGTTCCG CCCGTCTTCC CTCTCCTGAC CTCCTTTTCC TCCGCTGGGT GGGGCCCTGC CTGTTCTCTG CTCCCTGGCT TGGGGTTTCT TCTGTGTGTC TTCTTCCTCT GTTGGCTGGC TTTCTCCTTC TTTTGTCTTC CTGGGTGCCC CTTCTTCCTT TCTTGGGTCC TTGGTGCTTG GGCTGGG GCGTCTTGGG GTGCBGGGCC CBTCCTGCTG CGCCTGGGCG CTGCTGTGCG TCCGTCTGCT GGGGGGCCGG GGTGGCTGGG CCCTGCTTGC CGCACGACCC CGGGCCGACC CGAGGCTCGG GGGGCTGTGT TCTGGCGCTG GTGGGCTTGG GCCCCTCTGG GGGCTGGGTT TCCTGCTGCG CCTGGGCGCT GGCGTCTTGG GGTGCGGGGC CGGGGGGCCG GGGGGCCGCT GTTCGTGGGC CTGGGGGTGC CTGTGGCTGC CGGTTGCCCC GGTTGGTGGC GCCGTCCTGC TGCCGGTCGT TGGCTGGGTC CCCCCGCCCG TTTCCTGGGG TCCGCGTGGG GTGCTCCGGT TCCTCGTGCC GCTGCTGCCT TGTCTTTCCG GCCGTGGCGG CGTGGTGGTC CGCCCCCCCT GGCCTTCTGC TCGGGGTCTG GCTGGTTGCC GGTGCCCTTG GCGGCGGTCT TCTTCCTGGT GGCTCTGGGC CCGGCCGGTC TCGGGCGTCT CGTGTTCGCT CTTGTGCTGT TCGGGCCGCT CCTTCCTCTT CCGCCGCCGC CGCTCCCCGC CCGCTCGTCG CCCTGGCCCG GCCTCCTCCT GGCCGCTGTC TCGGGCGGCG GCCTTGGCGC TCCGTTTGGG GCTGCCTCTG GCGCTTCCGG CCCTCGGCCT GGGCGCTCTC TTCCGCCTGT GCTGGTGGCC CTCGTGGGCC CCTCCTGGCC TCCGGTGTCC TGTGGTCCCC CGGCTGGTGG CCGGGCCGGT TGGGCGGGCG TGGGCGCCGG CGGGTCCTCC GGGCTGCCCT TCTCCGCCGG GGGTCCCGCG CTCCTGCTGT TCCCTGGGCT CTTCTGCCTC TCTCCTGGGT GGGTGCTGGG TGCCGGGGTC TCCGGGCTTG CCCCGCGCTG CTGGGCGTTC TGCGGTCTTG GGGTTGTCTG TGGCCCCGCT CGTGTCGCCC TCCGTCGCCC GTCGCCGGCC TCGTCCCCTC CTGGGTGCGC GGCGGGCTGG TCCTGGCGTT TTGCTCCTTC CTGGGCGTCT TGGGGTGCBG GGCCCBTCCT GCTGCGCCTG GGCGCTGCTG TGCGTCCGTC TGCTGGGGGG CCGGGGTGGC TGGGCCCTGC TTGCCGCACG ACCCCGGGCC GACCCGAGGC TCGGGGGGCT GTGTTCTGGC GCTGGTGGGC TTGGGCCCCT CTGGGGGCTG GGTTTCCTGC TGCGCCTGGG CGCTGGCGTC TTGGGGTGCG GGGCCGGGGG GCCGGGGGGC CGCTGTTCGT GGGCCTGGGG GTGCCTGTGG CTGCCGGTTG CCCCGGTTGG TGGCGCCGTC CTGCTGCCGG TCGTTGGCTG GGTCCCCCCG CCCGTTTCCT GGGGTCCGCG TGGGGTGCTC CGGTTCCTCG TGCCGCTGCT GCCTTGTCTT TCCGGCCGTG GCGGCGTGGT GGTCCGCCCC CCCTGGCCTT CTGCTCGGGG TCTGGCTGGT TGCCGGTGCC CTTGGCGGCG GTCTTCTTCC TGGTGGCTCT GGGCCCGGCC GGTCTCGGGC GTCTCGTGTT CGCTCTTGTG CTGTTCCGGC CGCTCCTTCC TCTTCCGCCG CCGCCGCTCC CCGCCCGCTC GTCGCCCTGG CCCGGCCTCC TCCTGGCCGC TGTCTCGGGC GGCGGCCTTG GCGCTCCGTT TGGGGCTGCC TCTGGCGCTT CCGGCCCTCG GCCTGGGCGC TCTCTTCCGC CTGTGCTGGT GGCCCTCGTG GGCCCCTCCT GGCCTCCGGT GTCCTGTGGT CCCCCGGCTG GTGGCCGGGC CGGTTGGGCG GGCGTGGGCG CCGGCGGGTC CTCCGGGCTG EPI-109 39

CCCTTCTCCG CCGGGGGTCC CGCGCTCCTG CTGTTCCCTG GGCTCTTCTG CCTCTCTCCT GGGTGGGTGC TGGGTGCCGG GGTCTCCGGG CTTGCCCCGC GCTGCTGGGC GTTCTGCGGT CTTGGGGTTG TCTGTGGCCC CGCTCGTGTC GCCCTCCGTC GCCCGTCGCC GGCCTCGTCC CCTCCTGGGT GCGCGGCGGG CTGGTCCTGG CGTTTTGCTC CTTCCTGG CTGCCCCBGT TTTTGBTCCT CBCBTGCCGT GGGGBGGBCB BTGGCTGCCT CCCCGGGGTT TCTGCTGCTT GCTGCTTCTT TCCCGTCTCC CTTCTTTCCC GTCTCCTTTT TGCCTCTTTG GGTTCCTGTT GTTTCTGGCC TGCTTGGTGG CGGCTTGTGC GTTTCCTCTC TCTTCTCTTG GGTCTCCGCT TCTCGTCCTG CCTTTTCCTG TCTCTGTCGC GCCGTTCCTC CTCCGGCGTC CTCCTGCCCT GTGCTGTTTG CCTCGGGTGG TGCGGGTCCC GGTGCTCCCC CGGCGGGCCG GCTGGTTGCC TGGGCCTGTC TGGTGGGGTG TGGGGCCGCT GGGTTGGGGG TGTGGTGGGC TCTTCTGTGG CCTGTGGGGC TGTTGGTGTC TCTGTGGGCG TGTGCTGGGT CTTGGGGCTT CCTCCCTTGT GCTGGGTGCG GCCTCCCCGC CCCCCTTCTG GGCCGGTGGC CTGGCTCCTT GTGGGCGCTT CTGGCTCTTG CCCTGTCCTT CTTCGCCTCG TGGCTGCTGG GCTGC GCCGCCGCCG CCAAGATGGC GGACCTGGAG GCGGTGCTGG CCGACGTGAG CTACCTGATG GCCATGGAGA AGAGCAAGGC CACGCCGGCC GCGCGCGCCA GCAAGAAGAT ACTGCTGCCC GAGCCCAGCA TCCGCAGTGT CATGCAGAAG TACCTGGAGG ACCGGGGCGA GGTGACCTTT GAGAAGATCT TTTCCCAGAA GCTGGGGTAC CTGCTCTTCC GAGACTTCTG CCTGAACCAC CTGGAGGAGG CCAGGCCCTT GGTGGAATTC TATGAGGAGA TCAAGAAGTA CGAGAAGCTG GAGACGGAGG AGGAGCGTGT GGCCCGCAGC CGGGAGATCT TCGACTCATA CATCATGAAG GAGCTGCTGG CCTGCTCGCA TCCCTTCTCG AAGAGTGCCA CTGAGCATGT CCAAGGCCAC CTGGGGAAGA AGCAGGTGCC TCCGGATCTC TTCCAGCCAT ACATCGAAGA GATTTGTCAA AACCTCCGAG GGGACGTGTT CCAGAAATTC ATTGAGAGCG ATAAGTTCAC ACGGTTTTGC CAGTGGAAGA ATGTGGAGCT CAACATCCAC CTGACCATGA ATGACTTCAG CGTGCATCGC ATCATTGGGC GCGGGGGCTT TGGCGAGGTC TATGGGTGCC GGAAGGCTGA CACAGGCAAG ATGTACGCCA TGAAGTGCCT GGACAAAAAG CGCATCAAGA TGAAGCAGGG GGAGACCCTG GCCCTGAACG AGCGCATCAT GCTCTCGCTC GTCAGCACTG GGGACTGCCC ATTCATTGTC TGCATGTCAT ACGCGTTCCA CACGCCAGAC AAGCTCAGCT TCATCCTGGA CCTCATGAAC GGTGGGGACC TGCACTACCA CCTCTCCCAG CACGGGGTCT TCTCAGAGGC TGACATGCGC TTCTATGCGG CCGAGATCAT CCTGGGCCTG GAGCACATGC ACAACCGCTT CGTGGTCTAC CGGGACCTGA AGCCAGCCAA CATCCTTCTG GACGAGCATG GCCACGTGCG GATCTCGGAC CTGGGCCTGG CCTGTGACTT CTCCAAGAAG AAGCCCCATG CCAGCGTGGG CACCCACGGG TACATGGCTC CGGAGGTCCT GCAGAAGGGC GTGGCCTACG ACAGCAGTGC CGACTGGTTC TCTCTGGGGT GCATGCTCTT CAAGTTGCTG CGGGGGCACA GCCCCTTCCG GCAGCACAAG ACCAAAGACA AGCATGAGAT CGACCGCATG ACGCTGACGA TGGCCGTGGA GCTGCCCGAC TCCTTCTCCC CTGAACTACG CTCCCTGCTG GAGGGGTTGC TGCAGAGGGA TGTCAACCGG AGATTGGGCT GCCTGGGCCG AGGGGCTCAG GAGGTGAAAG AGAGCCCCTT TTTCCGCTCC CTGGACTGGC AGATGGTCTT CTTGCAGAAG TACCCTCCCC CGCTGATCCC CCCACGAGGG GAGGTGAACG CGGCCGACGC CTTCGACATT GGCTCCTTCG ATGAGGAGGA CACAAAAGGA ATCAAGTTAC TGGACAGTGA TCAGGAGCTC TACCGCAACT TCCCCCTCAC CATCTCGGAG CGGTGGCAGC AGGAGGTGGC AGAGACTGTC TTCGACACCA TCAACGCTGA GACAGACCGG CTGGAGGCTC GCAAGAAAGC CAAGAACAAG CAGCTGGGCC ATGAGGAAGA CTACGCCCTG GGCAAGGACT GCATCATGCA TGGCTACATG TCCAAGATGG GCAACCCCTT CCTGACCCAG TGGCAGCGGC GGTACTTCTA CCTGTTCCCC AACCGCCTCG AGTGGCGGGG CGAGGGCGAG GCCCCGCAGA GCCTGCTGAC CATGGAGGAG ATCCAGTCGG TGGAGGAGAC GCAGATCAAG GAGCGCAAGT GCCTGCTCCT CAAGATCCGC GGTGGGAAAC AGTTCATTTT GCAGTGCGAT AGCGACCCTG AGCTGGTGCA GTGGAAGAAG GAGCTGCGCG ACGCCTACCG CGAGGCCCAG CAGCTGGTGC AGCGGGTGCC CAAGATGAAG AACAAGCCGC GCTCGCCCGT GGTGGAGCTG AGCAAGGTGC CGCTGGTCCA GCGCGGCAGT GCCAACGGCC TCTGACCCGC CCACCCGCCT CCAGGAAGCT ACCTGGAGGA GGTGAGTCTT AGCGGATGAG TAGGAGTTGT CCACGGAGGA AGGTACACAG AAGGGCTTCC AGGCCCAGGA AACAGCAGAG GCACAGAAGT GAGAATGGGT GGGTGAGTTG GTGGGGAAAC TCCAGGTGCA GAGGATGGTA GCGAAACAAA CTGGAGCATT AAGGTCCAAG TCCTCCAAGA TCTTGACTTG CAGATTAAGG AGTTTGTTCA CCTAATCTGC TTTGGGCAGA GTGTGGTGAG TCCTAGAGAC CCCTCTAGGT CTCTCCTCTC AGTAGCCCCA GAAGGCCTGG AGAGCTGCTT CTGGGTGCCA AGCAGGCAGT GACTCCATCA GATCTAGATT TGGGAAAAGC ATCCCTGGTC AGGGCCTGCA TCAGGGCAGT GGCTGGCCAT GAGGACCCTG AGAAGTAGAC AGATTCACGG AGATTCTCAG GAGGCCAGAC AGGAGACTAT GGTGACAAAT TAGATTAGAG AAGGGGAGAG AATGAAGGAG CAGTTGGGGT AAAAGAAAAC TGAGGCTGAC ATGGGTATAT GGGTGGCGAG TGACTCACCA CCCACTGAGA GGAGAACCTC ACAAGCTCTG ACATGCTCTG GTTCCAGGTT CTGTTGGGGC TGATCCAAGA TGGTAGCCTA GAGGTGCACA GAGATGGGGG CCTTGCTTTG CAAAAGGATG CTGGCTGCTG GCCCACAGCA TGGTAATGAG ATTTGAGCTT TATGTGCCCA GGGCTGGGAG GAGGGTCCTG TCACTTTGAA AGCAAAGAGA GGCTCTAGAG AGGGGCATGT TGAGATAGGA ATGCTGCCTT GAGACACCTG GCTTTCCCCA CTCTGGGTGG CTCTCAGCAG GGTGGGTTTC CCCTGCCAGG CAGCACTGAA CCTCTGTGCG CTTCCGGCTG GGAGAGTTTT TACCGTAACT ACATGTGGAA CCATCCTGAA GGAACATCTG GATGGGATGG GGTACAGGGA AGGGAGCTGC CAAGAGTGCT GGCCAGGGAC CTGGGTCTAT GAGCTGGTTG GGGGGTGGGG TTGGGTGCAG GGTACTTGAT CCTGAGTGGG CCTTCTGCGG CCAGGATTGG TTCTAGAGTA GGAGGGGTGG GATCGGGGAT GGGGGAAGCC TGTAACTGCG CTGCAGTTGT CAGGTCCCAG GTTCTGGGTG ACCTACTAAG GATTCTGGGT CCAGTGTGGG TCCCAGGTTA GACGTCCTAG TCCTGAGTCC GTGTCCACAG TTCTGGGTGT TGAGTCTAGG ACAGTGATCT GGAGTTGACA GTCCAATCTA GGTCTGAGTC CTGACCCCAA GTCTAGAGTT CAGGGTCATG GTAGTAGCCT AGGGTCAGAA TCAAGGTTGG GGTCAGTAAC CAGGATGGGA TCGAGGTCAT GGTCCAAAAT CTGGATCTGG GGACCTGTTG GGGGTCTGAG GTGAGTGTCG CAGTCTGGGT ATGGCGTTGG AGACCCAGGG CTGTGATCTG AGGTCATGGT TAGAGTCTCA GGTGGTGGGC CAAGGTTTGA GTCTGGGGTC CTGTTTGGAG TCTGGTGTCA GGTCGTGGAC TGCGTCCAAG GTCAGGGAGT CCGGGGTTAT AGCCAGGGTC TGAGATGAAA GTCCCAGATG GTGTTCAGAG GTCTGAATCT GTGTCTTGGT GAGCGTCCAG GTTCCCTGTG ATCACGTTTG GTGTCAGGGC TGCGGCCCGA CTGGGGAGCC TGGGATCCAG AGATGTGACC CGAGGTTGTG GTCAGAGAAT GGGTCTCGGG TCGTCTTCGT GCCGGGTCCC TGTCGTGTTC CAGGCCCGGG TCTCCGTCCA GCATCGAGGG CCGAGGTCAC GGCCAGGGTC TGAGCCCGCG GTCGCAGGTC TGGTTCGGGG TCAGATTCCG CGCGGCCTCC AGGGGGCGCC GTCGCCGCCC GGCTCGGCCC CTCGCGGGCT CGCTGGCGTT GTGCGCGGCA GGCGGGGCCG GAGGCGGCGG CGGCTCCGGG GGCGCGGGCC GGGCGGCGGC GGCGGCGGCG CCCCGACTGC AGTCCCGGCG GGAGCGGAGC GCGAAGCGCG GGGCCGGGCC CGGAGCCGGC GCCATGGGGC GGCGCCGCCT GTGAGCGGCG GCGAGCGGAG CCGCGGGCGC CGAGCAGGGC CAGGCGGGAG CGTCGGCGCC CGAGGCCGAG CGAGCCGCGG CCGGGCCGGG CCGAGCGCCG AGCGAGCAGG AGCGGCGGCG GCGGCGGCGG CGGCGGGAGG AGGCAGCGCC GCCGCCAAGA TGGCGGACCT GGAGGCGGTG CTGGCCGACG TGAGCTACCT GATGGCCATG GAGAAGAGCA AGGCCACGCC GGCCGCGCGC GCCAGCAAGA AGATACTGCT GCCCGAGCCC AGGTGAGGAG AAGCT TCCCAGTTAA TACATAATCA ATATGCAATT TATTAATACA TCTCTCCATG TCCACTCCCC CTGTATCTTG CCATTCTTGA CCTGCATTTC CATCCTCCTT ACCTTCCCTA GAGGCCAACT CATTTTCTTT GAAAAACCTG GCATTTCCCA GAAAAAAAAG TGAAGGGCTG GGAGCTGTCC GTTGTCCTGA TTTGCTCCCT CTGCCCTTGC TTCCAAATGT GGTTGGAAAG AAGCACTATT GAAAAATCCC EPI-109 40

TAAACGCACC CCTGCAGGGT TGGCTCTACC CTGTAGCCAT GGACACATGC TGTTGATACC ACCTGCCTCA TGAGTCTCAC ATAATTTGCC CTTTCACACT ATCTACCCCA TCAGCCTTAC CAAAACCATA CCTGCATCCT GGGCAGCATC TGCCCTTCAA GAGACTAAGG AATCTCCTTG CAACCAAGAA TGACTAGACC AATGAGACAC CCTTTAAGGC CCCAGCACAA TATAGAAATC CCACAATATG GTAATCCCAG TAAGGAGCTA TCAAGCCATT GCAGGACCAT CTAGAATACA ACTAGAGTAT AGTTCCTTTC AATCCAGGAA CTATACTCTA ACAGCTTGGC TCACAGGAAC CAGAAGTGAA GATGATGAGG ATCAGGGCTG AGCCTGTGAG CACCAGCTCC ACCACTGACA CCAACCACAG ATTAAACAAG CATCTTGTGG ACCCCTGGGA TGGAAAGAAT AGTTGTTGCC TTATCAACCT CCCCCACAGC CCACACAGAA AAGATAAAAT CATCATGGCT ACAGTGTTAC AGAAGATGAT GACCCAAGGA GTAGGCCTGC CTGAGTGAAT GCTGAGAGTG ATAATGGGAG CAGTAGCATC TCAGAGACTA CAGCAGAAAC CATCCACATA AAGAGCTTTG CCCAAACTTA TGATAAAGGG CACCCTCAGA GACTCTCCCT ACTTTAATAT TAGCCCATTG CAGAAATGGT GAGTGGAAAG AGAAATCTTA GGAAGAACCC CTTAAAAAAG CAAAATGCTT TTTAGGTTTG TGCTGAAGAG CCTGGAAAAG AAATAAGGAC ACACACGCTG AGAAATCTTC CTCCTGCCCC AACACTGGGA TAATCTCCAA GGATCTCTCC ATATCTCATT CTCCTGGATA CACTGTCCAC TCAGAAATAT TGTGCAGAGT GCAGTAATTC AAAAGTGAGC TATTGTGTTA GGAGTGAAGG CAAGAGTATC GTAAAATAAA TCAAATTTGA AATGAATTCT CTTAAATTGC TTTATAGATG TTTAATGTAA GCCAGCAGCT ATTAAACGAT AAACCTTAAA TTCGAGAAAA ACTTGGTCAT TCAGAAACTA TAGAAACAGG CAGGACTTAT TGCGAGGGCA AACACAGAGT GAGCTCCAGC CTGCTTCAGG AAAATCTGCC AGTGCCATGA AGGATGTACT CTGTCTGCTC CACTGCACTA CTGCTCAGTA TGAGCCCATG CCATCAGCTG TCCCTGACCC ACAGGAGTTC TTTAGAAGAG ACTGGTCAAC AAAAGTTTCT AGGGTGTTTT ATACCTGCCA ACTCGAGGGT TAAAACAAGT TGCATAGAAA TGCTCAATCA AGAAAGACAC AGTCATTACT CAGAGAATAA TAAACAGCCT GGCAGCACAT GAATGAATAG AAAAAAGATG TTACATGCAA AGCATGAAAT AACCAAATTC CATAACAGAT GTTAATCTGT AATGTGTTTA GGAGAATTTA GAGGAAGTAT AAGATTTATT CTTTCATCAA AAAAATTATA GCCAATGAGG ATATATCTAT CAATTATCCA TCAAGTGGTG ATATGGCAGC ACAAGGTAAA ACACAAAGGA ATAAAACCAA CGTTTATTAA GAACCAATCA TGTGGCATTT CACATTGAGC ATCATATTTA ATTCTGAAAA AAATCCTTGT ACTGTATCAT TCTTCATATT TTATGGATGC AGTAACTAAG GCTGAGAACT TTAAAATTTT TCCTAAGTTC AGACACATAG CTAAGTGGCA GAACCAAGAT TCAAACTCAC CCCATCTAAC TGCAGAGCAA ACTGCATGCC TTAAATGTCA AAGTGAATAC TAGCACAGTT AATACAATGT TTGGAAACTC AGAGAAGGAA TGATCCCTCT GCATTATAGT TACTAAGGAA TCATTGCCAT TATTTAAATG CCAGTGCTTC TACATCAGGC CCAAATTTTC TGTCCTACTA ACTGTGAATC AAGACTTGAT TCAACCTCTA CTTGAGTATC TGCCGCAATG AGAAATCACT TACCTCCACT AACCACACAT TTATTTTATA ACAACAGATT GTTAGTAAGT CCTTTCTTAT ACATACTCAA CAGCTGCTTC CCAAGATGCT GTAGGATTAT GTCTAGAGTC AAACTAGCCA GAAGCAATGT CCAAAATACA CCATAACACT GTGCAGCAAA GGTCCTACTA CCACTTGTTT GGCCCAAACA TTCTAGGCAG CACTGGATAT CTGAATCATC AATTATTTCC ACAAACACTG ACCCCTCTAC CAGTCACCCT CACTAGAAGA ATTAATTCCA CATGATAATA GCTCCCTCAT GTTACTCCCT TCTAAGTCAA ATTGTACACC CCTTTATCTG ATTAACAGAG TCTAAGTCAC ATGACCTAAA TGCAAGAGAA CTGGGAATGG ACGTTTGTGG ATTCTACCTT AGTAAGGCAA AGTTATCATT GGGAATTCCT CTAATACAGG AAGGGTGTTC CAGAGACATT AAGGAGCCAT ATAAATGGAA AATGTCCACT ACAATCCATC ACTTGGTTGC CCCACATCAA CATTCATTCT TTTGCCACAC TTAAAGTTTC CAAGAACAAA AATTATCCCA CTGAACATAA TCTTTACTAT CTTTTATATA AAGGAAAATT AGACTTGACT CAGCAGAACT GAAATAACCC AGCTCTAACA GTTACTGCTT TTAACTTCAA GTACTGTGTC TCTAGGTGAT ACCTGCTCCA ACAATAGTTT GGTCACATTT TCAATTTGAT ATTCTCTAGT CTCCCAACTT GATAACTGTA CCCTAAACCA TAAAGTTCAC TACCAACATG CTATATATAA AATAACCAAA GGGGGAAGAA GAAAGAGAAA AAGGAAATCT CTTAAAATAC ACAGGTATAC ATATGACAAA GCAAAGAAGG AAATGTGAGC AGATAGTGCA GTCCTCGTTT CTGAAATTGG TCCCCTGACT GGGGCTATAC CTATTCCATT TCCTCACCCT CAGCCAGGCA GGTGGAGCAA AAACTTAAGT CTTGGTGGAT CTGAATCTTG ATGCTGTGGA GCTGTCTTAC TAGCCCCAGA CTACCTGCCT CTCAATTTCT AATTATATCA GTGAAAGCAA ACAGCTTTGA TTTGTTTAAG CCTCTGATTT TTTGGTCTAA CTGATGTAAG ACCACAAGGA CAAGAGTTCT CCAGCTCCGG ATTCTCTTCT GTTCTGTTAA TGGTGAAATG CCCGAGAGAA GAGTTGCCAA CTTTGGCAAA TAAAAAATAC AGGATTCCAG TTAAATTCAA ATTTAGATAA ACAACAATTT TTTAGTATTA GTGTGTCCCA TTCAATATTT GGACATACTT AACTAAAAAA TGATTTGTTG TTCATCTGAA ATACAAATTT AACTGGGCAT TCTGAATATT CTCTGGCAAC CCCCGAGAGA GTGAAGAAAG TGGTACAAGG ACACTTAAGA AGACCAGATT TGAAAAGACA TTACGGATGT GTTTAAATGT CTTATTCTAG AGAGAGTTAG AGCTGTAGGT AGAACTTGGG AAATTAAGTT AAAAGCAGAC ACAGAGACCT GGCCAATATA TACTAAGGAG TGGATCACTC TGGTCACAAG CCCAACCTGA GACCAAGGGC ATAGTGAGAT GATTTGGGAA AGGCACTTAT ACACTACTCA TCCCCGTCTT TGAACTAAAT GCCTTATAAA TCTCCAAGAG AAATGACAGT CCACCATGTG GACTGCTTTC TGTAAGTCCA GGGAAAATAA AAGCTATGTG CTTGAAACCC ACTTCTGATA TTATAAGGTG TGTGATCTTT GTCATGTTAA TGGGTCTGAG TATCAATTCT ACAATTGTAA AGTGACAGTA ATGGTGTGTC CCCAGGTTGT TGTGGAAAGC TTGATTCTTA ATGCAACAGT AGGAAACCCC AGCCTCTCTG GAGCAAACAC CCTTCTACAT CTTTACTTCC CCTGCACATT GGCAGGACTC TATTCCTCTA TTTCTCTCTA GTGCTAGAGC AGAAAGGGAC CTTGATTTGA TATCAGGAAA ATCTATTTCT GAACCATAAG CTATGATAGC TGATTTAAAA AATTGACTAT CATGACATGA TAATGATCAT AATGGTAATA CATATTGATA GGGTTGCCGT GAAAGTAATA ATATATCTAA GAGTTGTGAC AATATATGAT ACGCCTAGAC TCTCAGAAAA TGCTAATTCC AATCCCAATT GCTCTTTGCA TAAAGTTCTG TCCTAGGGTC TGTTCTTTTC CCACATCTAC CCTCCTTGGA TCTCTCTTCT GTCTTTTTCA TGTGGTTCAG AGGAGGAGAG AGATCCAGGT CAATGTTTTT CAAATTACAA GGAATTATCA TTTAAATGGG GAAGAAGCTC AAGTTTTGAC GTGTAGTGGA ATTGGAGTGG AGTGGAGTGG AATGGAAACT AACAGGAAGA CACTGCACAT GGTTAAGATA AAGATTGTTT CCTGAAACCT TTAATTTGTG CTTACATACT CACACATACA TATGTGCATG CACTGGGACT CTGCAATATG CATTTCTGAC TATGGAACAT AGCCATAAAA GTCTTTGCAC TGAACGTTCA GTGGGCCTTT CACAAGCTGC CCTAATTGGG AAAGAAAAAC ATGGTCCCTC CATTTCCTGC CCCCAACTCC AGAAAAGTCA CCATAGTTGA GGGTACATCT GAGAAGCCAG CACTTGGGAG TTCAGGGCTC AAGTTCCTTT CTAGAAAAAC ACTGGGTGAT TCTAGGGGAA CTTCCGATCA GAAACAGCCA ATTCAGAGTG AGAGAAGAAA ACGTGACCAT GCAGTTCCTG TGGTTACCAG CCTTGCCCCT CTCTTGCCTT CTGGGAGTTA TAAAACCCAA GACTGGAAAG GAAAACCAGC ATTTGCTCAG GCAGCCTCTC TGGGAAGATG CTGCTTCTTC CTCTCCCCCT GCTGCTCTTT CTCTTGTGCT CCAGAGCTGA AGCTGGTGAG TATCAGGGTT CTTCCCTCTG AAATCTGCAG TATCAGCTCC TGAAACAAAG ATGTTTAGTC TGAAATAGCT GACTCCTAAA CAGGGTTCCA AGATCTCTCT TCAAGAGTCC CACAGAGGAA ATTTCCACTT GGGATGTGTG CCACCCCACC CCCACCCCCA CCCACTGCCA TTCTCTACAG CCTAGGACAC CCCCAGGAAC AAGGAATTTC ACCTCAATTG TAGAAAAGCC CAGAGCAAGT GGAAGGAAAA GGGGTATCCC CAGGAAAACA GACATGTCCT CTTAATCTTC TGAGCATCAG GGCTACCCAT TACTTTGTGA CTTTCTCACT CTGTGACCAT GCTCAAGAGC TATGGAGAAA TCTAAAACAG GAACCTGGAC AGTGGGTCCT ACACAGAGAC AGAGGAGAGT GGGCCAGGGC AAGGTGGGAG TGGGAGAAGT CTGAGATGAA AACATCAGAA TGGAGCAGAG GCAAGAATGA GATTTCACCT GGGAGGTTAT GGGTGGGGAA AGATACGAAA TACAGGAGAC EPI-109 41

AGGAGAGGGA AGATGGGCGG AACACAGGGT GAGAATGAGA TTCCAGGGAA GCCTAGCTCA GCTTTAACCC AATTTGTCCA TTCATTGGAG AGAGTATCTA TGGCCGTGTT CAAACCCTGG GGTGCTCTGT TCCAGGGGAG ATCATCGGGG GCACAGAATG CAAGCCACAT TCCCGCCCCT ACATGGCCTA CCTGGAAATT GTAACTTCCA ACGGTCCCTC AAAATTTTGT GGTGGTTTCC TTATAAGACG GAACTTTGTG CTGACGGCTG CTCATTGTGC AGGAAGGTGA GACAACAGGG TCTATTTATC TCCAAATGGG AGATGAACAA CCAGAGTAGC ATCCAGGAAT ACACCTGCAC TGGGGACTGA AGAGGGGGTC CTGGGTCTTG TCAACTTTCA GGAGAGGGAA GACTTTGGGC TGAAAGACTT TAGTCTGTGT TTGAATAGTT CCTTGAGCCT CAGTCACTGA GCTAAGCTCC CTTCGGAGGA AAAGGAGGTC CTGTCCGAAG GTCCCTCTTG TTGCAGTAGC ACCCCTCACC CCTACCCAAC TCAAGACACA CGGCTCACTT TTCAGGGCCC CACCCAGTCT CAGGGCCACT TCCTCTATGG CCTTTTCAAG AACACTGGCT CTAGTTCTCA GGGTCCTGAA CCCATCATTT TATGGGAGCA GAGAACAGGT CTACATAAGA CCCCCACTTT CCCGTTTTAA CTGATATCTC CTGCTTCAGG GGCTGGCCCT CATGCAGGGT TCCCTGAATT AGGAAGTGTG AACCCTGTCC CCTGAGTCCT CCCTGGCCTG TTCAGTCCCC AGCAATTCCA GGGGTCGTAG AAATTGTGTC TGTTTCCTGA GAAAGCTCTT TCATGAGTTA AGCCTGAGCC CTCAAATGCC ACAAGTGGCC CATGAAAAGG GAGATGGGTA GAGTCCGGCN ACCCAGTGAC AGAGTTTAGT CCTCTTTTCT CAGAATGAGC TCACCTCAGA AGAAACCCCA AGCCATCACT GTCGCCTCCT TTTCCTTCCT TCTTCCTCAC AGCAGGTCTA TAACAGTCAC CCTTGGAGCC CATAACATAA CAGAGGAAGA AGACACATGG CAGAAGCTTG AGGTTATAAA GCAATTCCGT CATCCAAAAT ATAACACTTC TACTCTTCAC CACGATATCA TGTTACTAAA GGTGACAACA CCTCTCTTCT CCCTTTCCAC TTCCCATTCT CCTAAGCTTC TCCTTCAGGT CCTCATTGCC CTGAATTTTT CTTAGGACTT GGCTATAACA TGAAGCTACT CACCCTGTCC CTCCCTGATC ACCTCCAACT GTCCAGAGCC CATTTCGAGG ACTGACAGTC CTTCATTCCC TTCACAGTTG AAGGAGAAAG CCAGCCTGAC CCTGGCTGTG GGGACACTCC CCTTCCCATC ACAATTCAAC TTTGTCCCAC CTGGGAGAAT GTGCCGGGTG GCTGGCTGGG GAAGAACAGG TGTGTTGAAG CCGGGCTCAG ACACTCTGCA AGAGGTGAAG CTGAGACTCA TGGATCCCCA GGCCTGCAGC CACTTCAGAG ACTTTGACCA CAATCTTCAG CTGTGTGTGG GCAATCCCAG GAAGACAAAA TCTGCATTTA AGGTGATCCT CCAACTAGGT TTCCTCTCCA AAACTCACTG TTCAGGGACC TGAATGCTCT TAGAAGGAGA TGGGGTCAGC AGGTTGTCAG TCAGGTGACA GGGTGAGCAT CACAGGAATT GCTGTCCTCC CGTGGTCCAA GACAGCCTCT GACCATCCAT TCCAGTCTAC TGCACTGGGG GCATGGGGTG ACTGTGGAGA ATGTGGATGA CGGTCCCAAG AAAGGAAGAA GGGGCATCAG AACTAGATGT ATAAGTGAGG AGCTCCACCT CCTGGGTCTG ACTTTAGGTC TCACTGTGAC TCCAAGCTGG CTGGCAGACA GGAGTGGAGG ACTTCCCGGG CTCACCTTCT TCTCTCTCTC CTCCCCCTAC AGGGAGACTC TGGGGGCCCT CTTCTGTGTG CTGGGGTGGC CCAGGGCATC GTATCCTATG GACGGTCGGA TGCAAAGCCC CCTGCTGTCT TCACCCGAAT CTCCCATTAC CGGCCCTGGA TCAACCAGAT CCTGCAGGCA AATTAATCCT GGATCCTGAG CCAGCCTGAA GGGAAGCTGG AACTGGACCT TAGCAGCAAA GTGTGTGCAA CTCATTCTGG TTCTACCCTT GGTTCCCTCA GCCACAACCC TAAGCCTCCA AGAGGTCTCC TACAGGTAAC AGAACTTTCA ATAAACTTCA GTGAAGACAC AGCTTCTAGT CGTGAGTGTG TGTCCCTCTC TGCTGCTCTC TTCTCCTGCA CATGTGACCT GATTCCCAGC CCAAGCACCA AGGA CACCGCTCCT GTCAGCCAAC AAATATCCAT TGAGCGACAC CTGTGTCCCA GGTGCTGCTC TGGGCCCTGG GAGAAGTGCA TCAGTGGGCT TGGTAGTAGA GGGTAGGGAT GGAGTGAAGG GTAGGCAGGA AGAATGTCCC CAGGCTGGTA GGAGGTGGGG TGGGGGGTTT CAGTCTCAAA ACTCCCATGA AAACCAGAGA GAAGTTTCAG AACTCCACCC AAGAGGCTGG GTTTCTAGGG CCCAGAGCTG CCCTCCCCCA CCCTAGAATG GGCTATAAAA GTCCCTTCCC AGCTACGTCC AGAGAAGAGC TGGAGGAAGT GAGAGGTCGG CTGGGGGTCC TCAAAGTGAG AGGGGAGCAG AGGATCCTCC CGTGCAGGCT GTGGATGTCA CTCACTTCCC AGCTGGTGAA GCCTCGCTGC AGAGATGCAT CTGCTCCCAG CCCTGGCAGG GGTCCTGGCC ACACTCGTCC TCGCCCAGCC CTGTGAGGGC ACTGACCCAG GTAATAGTCC CCTAGACAGG CAAGGAGGAG GGAGGGGAAA TGGAAGGGGA AGCACTTGGG TCTTGGAGGG GGTCTTGTGG CTTGCTGAAC CCTGAGTCCC CATCTCTTTG AACAGCCTCC CCTGGGGCAG TGGAGACCTC GGTCCTGCGA GACTGCATAG CAGAGGCCAA GTTGCTGGTG GATGCTGCCT ACAATTGGAC CCAGAAGAGG TGGACTTGGG TCTGGGGGCT GCATGGGCCT GGGAGGATCA GT TAATACCTTG TGGGGTCAGG GAGCCCATGT CCCGTGCTGA TGTTATTTCC CCACCAGGTC CGGGCTGTCT CCAACCAGAT TGTGCGCTTC CCCAATGAGA GACTGACCTC CGACCGTGGC CGAGCCCTCA TGTTCATGCA GTGGGGCCAG TTCATTGACC ATGACCTGGA CTTCTCCCCG GAGTCCCCGG CCAGAGTGGC CTTCACTGCA GGCGTTGACT GTGAGAGGAC CTGCGCCCAG CTGCCCCCCT GCTTTCCCAT CAAGGTACCT ACCCTCAGCC AATCTCCCAT GCCCTTGTGT GGCCTCCCCC AAAGGCAAGG TGCTGGGGGT GGGGATCTGG AAGACTGGAG CACCATCCTT AAGGAGCTGC CTGTGGAGCT AGGGTATGAG ACAGAGACAC AAG CACTGTCTCC TCTTCCATCT CAGATCCCAC CCAATGACCC CCGCATCAAG AACCAGCGTG ACTGCATCCC TTTCTTCCGC TCGGCACCCT CATGCCCCCA AAACAAGAAC AGAGTCCGCA ACCAGATCAA CGCGCTCACC TCCTTTGTGG ACGCCAGCAT GGTGTATGGC AGTGAGGTCT CCCTCTCGCT GCGGCTCCGC AACCGGACCA ACTACCTGGG GCTGCTGGCC ATCAACCAGC GCTTTCAAGA CAACGGCCGG GCCCTGCTGC CCTTCGACAA CCTGCACGAT GACCCCTGTC TCCTCACCAA CCGCTCGGCG CGCATCCCCT GCTTCCTGGC AGGTCAGACA GGGAGGAAGG TGGTGTCTTC CCAGGAAACA GCCATCCCTG GGGTCCCAAC TGGGAAGCAA TGGTGGGATG TGGTGAAGGT ACATGGTTTG GGACCTCAGT ATTAGGCACA CCATAAGCAT GGATCTGTGC AC TGAAGAGATG GAGGTCCAGT GAGGGCCAGG AGTTTGGCCC ACCCCGTCTC TCCCATCCCC AGCCCTGGGT CTACCCTGGT AGAAAGACAT TTCTCTGGGA AAGGCTGCAG TAAATCTGAG CTTGGGGTTT TCAAGGTGAC ACCCGATCAA CGGAAACCCC CAAACTGGCA GCCATGCACA CCCTCTTTAT GCGAGAGCAC AACCGGCTGG CCACCGAGCT GAGACGCCTG AATCCCCGGT GGAATGGAGA CAAACTGTAC AATGAGGCTC GGAAGATCAT GGGGGCCATG GTCCAGGTAA GGAGCTCTGC ATCCCAGCAT CCCCC CTTTGTATCT CCACCCACCA ATAGTAAATT AATGTTGTCA CATTTGACGT GATGACAATA AAGAATATGT CTGAGCCACC CTTTGAAAAG GCAAGGGTAT GGGTGAGTAG CCTCTGGGGA ATGTTCCTCC TGTCTTCCCT TCCAGATCAT CACCTACCGA GACTTTCTGC CCCTGGTTCT GGGCAAGGCC CGGGCCAGGA GAACCCTGGG GCACTACAGG GGGTACTGCT CCAATGTGGA CCCACGGGTG GCCAATGTCT TCACCCTGGC CTTCCGCTTT GGCCACACAA TGCTCCAGCC CTTCATGTTC CGCTTGGACA GTCAGTACCG GGCCTCCGCA CCCAACTCGC ATGTCCCACT TAGCTCTGCC TTCTTTGCCA GCTGGCGGAT CGTGTATGAA GGTGACCAGG TTTTCCAGGG GGCAAATGGG GGTGAGGGTG GGGAGCATGC CCTCCCCTAG GTGG TCCAGCTGCT TCATGTCTCT CCAGAACTCT GTTTCCTGAC AAACGTTACT AACATACCCG ACTGGCTTGT CCAGCTCTGG GCTAGCTTGG CATCATGTGA TAACCCAAGT AGCTTCCCAG AGGCTGGTCC AATCTGTGCT GCTCACATTC CCTGCCACCA GGGGGCATCG ACCCCATCCT CCGGGGCCTC ATGGCCACCC CTGCCAAGCT GAACCGTCAG GATGCCATGT TAGTGGATGA GCTCCGGGAC CGGCTGTTTC GGCAAGTGAG GAGGATTGGG CTGGACCTGG CAGCTCTCAA CATGCAACGA AGCCGGGACC ACGGCCTTCC AGGTGAGGGG GCTGTCCACC TCTTCTCCCA GCTTTGCTCG GGCCAGGCTG CTCAAGGGGT TCTGGGAAGA CCCTGGTACC CGACTGCCTG GTAGGTTCTG GTGGCAGAAA CGAGGTGTTT TCACCAAAAG ACAGCGCAAG GCCCTGAGCA GAATTTCCTT GTCTCGAATT ATATGTGACA ATACCGGTAT CACCACGGTT TCAAGGGACA TCTTCAGAGC CAACATCTAC CCTCGGGGCT TTGTGAACTG CAGCCGTATC CCCAGGTTGA ACCTATCAGC CTGGCGAGGG ACATGAGGCT TCTGCAGGTA AGGGGAGGCC ACCTCCAGCA CCCTGGGCTG GTTAAGCCTC hPl-109 42

ACATCCTTCC CTGGATGGAT GGCTGAGTCC TCTTAGGTCT CTAAGCAGAG AAAACAGAAC TTGTCACTAG GTACTCTTTC CAAGTGGCTT CCCAATGTGC TAGTTTCTGG GCTGACAGTC AATTCCAGGC CCTAGGACTT TGGGGGGAAA TTAGGAGCAT CCAACTA GAATTCCGTG GCCAGGACCC CTGCCAGGGC ACTGACCCAG CCTCCCCTGG GGCAGTGGAG ACCTCGGTCC TGCGAGACTG CATAGCAGAG GCCAAGTTGC TGGTGGATGC TGCCTACAAT TGGACCCAGA AGAGCATCAA GCAGCGGCTT CGCAGCGGTT CAGCCAGCCC CATGGACCTC CTGTCCTACT TCAAACAACC GGTAGCAGCC ACCAGGACAG TTGTTCGGGC CGCAGATTAT ATGCATGTGG CTTTGGGGCT GCTTGAAGAG AAGTTACAAC CCCAGCGGTC CGGACCCTTC ATTGTCACTG ATGTGCTAAC AGAACCACAG CTGCGGCTGC TGTCCCAGGC CAGTGGCTGT GCTCTCCGGG ACCAGGCCGA GCGCTGCAGC GACAAGTACC GCACCATCAC TGGACGGTGC AACAACAAGA GGAGACCCTT GCTAGGGGCC TCCAACCAGG CTCTGGCTCG CTGGCTGCCC GCCGAGTATG AGGATGGGCT GTCGCTCCCC TTCGGCTGGA CCCCCAGCAG GAGGCGCAAT GGCTTCCTTC TCCCTCTTGT CCGGGCTGTC TCCAACCAGA TTGTGCGCTT CCCCAATGAG AGACTGACCT CCGACCGTGG CCGAGCCCTC ATGTTCATGC AGTGGGGCCA GTTCATTGAC CATGACCTGG ACTTCTCCCC GGAGTCCCCG GCCAGAGTGG CCTTCACTGC AGGCGTTGAC TGTGAGAGGA CCTGCGCCCA GCTGCCCCCC TGCTTTCCCA TCAAGATCCC ACCCAATGAC CCCCGCATCA AGAACCAGCG TGACTGCATC CCTTTCTTCC GCTCGGCACC CTCATGCCCC CAAAACAAGA ACAGAGTCCG CAACCAGATC AACGCGCTCA CCTCCTTTGT GGACGCCAGC ATGGTGTATG GCAGTGAGGT CTCCCTCTCG CTGCGGCTCC GCAACCGGAC CAACTACCTG GGGCTGCTGG CCATCAACCA GCGCTTTCAA GACAACGGCC GGGCCCTGCT GCCCTTCGAC AACCTGCACG ATGACCCCTG TCTCCTCACC AACCGCTCGG CGCGCATCCC CTGCTTCCTG GCAGGTGACA CCCGATCAAC GGAAACCCCC AAACTGGCAG CCATGCACAC CCTCTTTATG CGAGAGCACA ACCGGCTGGC CACCGAGCTG AGACGCCTGA ATCCCCGGTG GAATGGAGAC AAACTGTACA ATGAGGCTCG GAAGATCATG GGGGCCATGG TCCAGATCAT CACCTACCGA GACTTTCTGC CCCTGGTTCT GGGCAAGGCC CGGGCCAGGA GAACCCTGGG GCACTACAGG GGGTACTGCT CCAATGTGGA CCCACGGGTG GCCAATGTCT TCACCCTGGC CTTCCGCTTT GGCCACACAA TGCTCCAGCC CTTCATGTTC CGCTTGGACA GTCAGTACCG GGCCTCCGCA CCCAACTCGC ATGTCCCACT TAGCTCTGCC TTCTTTGCCA GCTGGCGGAT CGTGTATGAA GGGGGCATCG ACCCCATCCT CCGGGGCCTC ATGGCCACCC CTGCCAAGCT GAACCGTCAG GATGCCATGT TAGTGGATGA GCTCCGGGAC CGGCTGTTTC GGCAAGTGAG GAGGATTGGG CTGGACCTGG CAGCTCTCAA CATGCAACGA AGCCGGGACC ACGGCCTTCC AGGGTACAAT GCTTGGAGGC GCTTCTGTGG GCTCTCCCAG CCCCGGAATT TGGCACAGCT TAGCCGGGTG CTGAAAAACC AGGACTTGGC AAGGAAGTTC CTGAATTTGT ATGGAACACC TGACAACATT GACATCTGGA TTGGGGCCAT CGCTGAGCCT CTTTTGCCGG GGGCTCGAGT GGGGCCTCTT CTGGCTTGTC TGTTCGAGAA CCAGTTCAGA AGAGCCGAGA CGGAGACAGG TTCTGGTGGC AGAACGAGGT GTTTTCACCA AAGACAGCGC AAGGCCCTGA GCAGAATTTC CTTGTCTCGA ATTATATGTG ACAATACCGG TATCACCACG GTTTCAAGGG ACATCTTCAG AGCCAACATC TACCCTCGGG GCTTTGTGAA CTGCAGCCGT ATCCCCAGGT TGAACCTATC AGCCTGGCGA GGGACATGAG GCTTCTGCAG GAGTCTATCC CAAGTCTCCA ACTTTTGGAG ACAAGGGGAA GGGGAGGACC ATGAGGCTGC CTTGTCTCCC TGGAGCAAGT GCAGGCTCGT GACGCTTCTG CTGGCTACAG CTCAGAGCTG GGTTCCCCAG CCAGGAGTGA AGGCTGGGGG CTCCTATCAG CAATGGACCT TCCGCCTTGG GAGCCTCTTA GGTATTAGGC TATGAATCAG CGCCACGTGC AAAGGCTTGG GAGCCAAGCC ATGTGGTCTT GCACCCCAGG CAAGAAAAGT CAGCTGGAGG GTTTACAGCA CTTTCTACTG TTTCCCAGCC CTCCCTCCCC TCCCTCACCA TGACTAAGAG ACCACTCGGT CCTAGCCTCC AGACACCCCA CAATACTCCT CTGAGCCTGA GGCCAGGCAG CATGCTCTGC TTCTACCAAT AAAGCACTGC CGGAATTC CATATGTATG GGAATACTGT ATTTCAGGCA TTATAAGGAA TGAAATTATA GGCCGGGCAT

TGTGGCTAAC CCTTGTAATC CTAGCACTTT GAGAGGCTGA AGTGGGCAGA TCACTTGAGC TTCAGAGTTC

GAGACCAGCA TGGACAACAT GGTGAAACCC AGTCTCTACC AAAAACACAA AAATATTAGC TGGGTGTGGT

GGTGCATGCC TGTAGTCCCA GCTACTCAGG AGGCTGAGGT GGGAGGATCG CTTGAGCCTG GGAGGCAGAA

GTTGCAATGA GCAGAGATCG TGCCACTCCG CTCCAGTCTT GGTGACAGAA TGAGACTCCA TCTCAAAAAT

AAATAAATAA ATAAATAAAA TAAATGAAAT GAAATTATAA GAAATTACCA CTTTTTCATG TAAGAAGTGA

TCATTTCCAT TATAAGGGAA GGAATTTAAT CCTACCTGCC ATTCCACCAA AGCTTACCTA GTGCTAAAGG

ATGAGGTGTT AGTAAGACCA ACATCTCAGA GGCCTCTCTG TGCCAATAGC CTTCCTTCCT TTCCCTTCCA

AAAACCTCAA GTGACTAGTT CAGAGGCCTG TCTGGAATAA TGGCATCATC TAATATCACT GGCCTTCTGG

AACCTGGGCA TTTTCCAGTG TGTTCCATAC TGTCAATATT CCCCCAGCTT CCTGGACTCC TGTCACAAGC

TGGAAAAGTG AGAGGATGGA CAGGGATTAA CCAGAGAGCT CCCTGCTGAG GAAAAAATCT CCCAGATGCT

GAAAGTGAGG CCATGTGGCT TGGCCAAATA AAACCTGGCT CCGTGGTGCC TCTGTCTTAG CAGCCACCCT

GCTGATGAAC TGCCACCTTG GACTTGGGAC CAGAAAGAGG TGGGTTGGGT GAAGAGGCAC CACACAGAGT

GATGTAACAG CAAGATCAGG TCACCCACAG GCCCTGGCAG TCACAGTCAT AAATTAGCTA ACTGTACACA

AGCTGGGGAC ACTCCCTTTG GAAACCAAAA AAAAAAAAAA AAAAAAGAGA CCTTTATGCA AAAACAACTC

TCTGGATGGC ATGGGGTGAG TATAAATACT TCTTGGCTGC CAGTGTGTTC ATAACTTTGT AGCGAGTCGA

AAACTGAGGC TCCGGCCGCA GAGAACTCAG CCTCATTCCT GCTTTAAAAT CTCTCGGCCA CCTTTGATGA

GGGGACTGGG CAGTTCTAGA CAGTCCCGAA GTTCTCAAGG CACAGGTCTC TTCCTGGTTT GACTGTCCTT

ACCCCGGGGA GGCAGTGCAG CCAGCTGCAA GGTGAGTTGC C CATATGTATG GGAATACTGT ATTTCAGGCA TTATAAGGAA TGAAATTATA GGCCGGGCAT TGTGGCTAAC CCTTGTAATC CTAGCACTTT GAGAGGCTGA

AGTGGGCAGA TCACTTGAGC TTCAGAGTTC GAGACCAGCA TGGACAACAT GGTGAAACCC AGTCTCTACC

AAAAACACAA AAATATTAGC TGGGTGTGGT GGTGCATGCC TGTAGTCCCA GCTACTCAGG AGGCTGAGGT

GGGAGGATCG CTTGAGCCTG GGAGGCAGAA GTTGCAATGA GCAGAGATCG TGCCACTCCG CTCCAGTCTT

GGTGACAGAA TGAGACTCCA TCTCAAAAAT AAATAAATAA ATAAATAAAA TAAATGAAAT GAAATTATAA

GAAATTACCA CTTTTTCATG TAAGAAGTGA TCATTTCCAT TATAAGGGAA GGAATTTAAT CCTACCTGCC

ATTCCACCAA AGCTTACCTA GTGCTAAAGG ATGAGGTGTT AGTAAGACCA ACATCTCAGA GGCCTCTCTG

TGCCAATAGC CTTCCTTCCT TTCCCTTCCA AAAACCTCAA GTGACTAGTT CAGAGGCCTG TCTGGAATAA

TGGCATCATC TAATATCACT GGCCTTCTGG AACCTGGGCA TTTTCCAGTG TGTTCCATAC TGTCAATATT

CCCCCAGCTT CCTGGACTCC TGTCACAAGC TGGAAAAGTG AGAGGATGGA CAGGGATTAA CCAGAGAGCT

CCCTGCTGAG GAAAAAATCT CCCAGATGCT GAAAGTGAGG CCATGTGGCT TGGCCAAATA AAACCTGGCT

CCGTGGTGCC TCTGTCTTAG CAGCCACCCT GCTGATGAAC TGCCACCTTG GACTTGGGAC CAGAAAGAGG

TGGGTTGGGT GAAGAGGCAC CACACAGAGT GATGTAACAG CAAGATCAGG TCACCCACAG GCCCTGGCAG

TCACAGTCAT AAATTAGCTA ACTGTACACA AGCTGGGGAC ACTCCCTTTG GAAACCAAAA AAAAAAAAAA

AAAAAAGAGA CCTTTATGCA AAAACAACTC TCTGGATGGC ATGGGGTGAG TATAAATACT TCTTGGCTGC

CAGTGTGTTC ATAACTTTGT AGCGAGTCGA AAACTGAGGC TCCGGCCGCA GAGAACTCAG CCTCATTCCT bPl-109 43

GCTTTAAAAT CTCTCGGCCA CCTTTGATGA GGGGACTGGG CAGTTCTAGA CAGTCCCGAA GTTCTCAAGG CACAGGTCTC TTCCTGGTTT GACTGTCCTT ACCCCGGGGA GGCAGTGCAG CCAGCTGCAA GGTGAGTTGC C

CTGCTTTAAA ATCTCTCGGC CACCTTTGAT GAGGGGACTG GGCAGTTCTA GACAGTCCCG AAGTTCTCAA GGCACAGGTC TCTTCCTGGT TTGACTGTCC TTACCCCGGG GAGGCAGTGC AGCCAGCTGC AAGCCCCACA GTGAAGAACA TCTGAGCTCA AATCCAGATA AGTGACATAA GTGACCTGCT TTGTAAAGCC ATAGAGATGG CCTGTCCTTG GAAATTTCTG TTCAAGACCA AATTCCACCA GTATGCAATG AATGGGGAAA AAGACATCAA CAACAATGTG GAGAAAGCCC CCTGTGCCAC CTCCAGTCCA GTGACACAGG ATGACCTTCA GTATCACAAC CTCAGCAAGC AGCAGAATGA GTCCCCGCAG CCCCTCGTGG AGACGGGAAA GAAGTCTCCA GAATCTCTGG TCAAGCTGGA TGCAACCCCA TTGTCCTCCC CACGGCATGT GAGGATCAAA AACTGGGGCA GCGGGATGAC TTTCCAAGAC ACACTTCACC ATAAGGCCAA AGGGATTTTA ACTTGCAGGT CCAAATCTTG CCTGGGGTCC ATTATGACTC CCAAAAGTTT GACCAGAGGA CCCAGGGACA AGCCTACCCC TCCAGATGAG CTTCTACCTC AAGCTATCGA ATTTGTCAAC CAATATTACG GCTCCTTCAA AGAGGCAAAA ATAGAGGAAC ATCTGGCCAG GGTGGAAGCG GTAACAAAGG AGATAGAAAC AACAGGAACC TACCAACTGA CGGGAGATGA GCTCATCTTC GCCACCAAGC AGGCCTGGCG CAATGCCCCA CGCTGCATTG GGAGGATCCA GTGGTCCAAC CTGCAGGTCT TCGATGCCCG CAGCTGTTCC ACTGCCCGGG AAATGTTTGA ACACATCTGC AGACACGTGC GTTACTCCAC CAACAATGGC AACATCAGGT CGGCCATCAC CGTGTTCCCC CAGCGGAGTG ATGGCAAGCA CGACTTCCGG GTGTGGAATG CTCAGCTCAT CCGCTATGCT GGCTACCAGA TGCCAGATGG CAGCATCAGA GGGGACCCTG CCAACGTGGA ATTCACTCAG CTGTGCATCG ACCTGGGCTG GAAGCCCAAG TACGGCCGCT TCGATGTGGT CCCCCTGGTC CTGCAGGCCA ATGGCCGTGA CCCTGAGCTC TTCGAAATCC CACCTGACCT TGTGCTTGAG GTGGCCATGG AACATCCCAA ATACGAGTGG TTTCGGGAAC TGGAGCTAAA GTGGTACGCC CTGCCTGCAG TGGCCAACAT GCTGCTTGAG GTGGGCGGCC TGGAGTTCCC AGGGTGCCCC TTCAATGGCT GGTACATGGG CACAGAGATC GGAGTCCGGG ACTTCTGTGA CGTCCAGCGC TACAACATCC TGGAGGAAGT GGGCAGGAGA ATGGGCCTGG AAACGCACAA GCTGGCCTCG CTCTGGAAAG ACCAGGCTGT CGTTGAGATC AACATTGCTG TGATCCATAG TTTTCAGAAG CAGAATGTGA CCATCATGGA CCACCACTCG GCTGCAGAAT CCTTCATGAA GTACATGCAG AATGAATACC GGTCCCGTGG GGGCTGCCCG GCAGACTGGA TTTGGCTGGT CCCTCCCATG TCTGGGAGCA TCACCCCCGT GTTTCACCAG GAGATGCTGA ACTACGTCCT GTCCCCTTTC TACTACTATC AGGTAGAGGC CTGGAAAACC CATGTCTGGC AGGACGAGAA GCGGAGACCC AAGAGAAGAG AGATTCCATT GAAAGTCTTG GTCAAAGCTG TGCTCTTTGC CTGTATGCTG ATGCGCAAGA CAATGGCGTC CCGAGTCAGA GTCACCATCC TCTTTGCGAC AGAGACAGGA AAATCAGAGG CGCTGGCCTG GGACCTGGGG GCCTTATTCA GCTGTGCCTT CAACCCCAAG GTTGTCTGCA TGGATAAGTA CAGGCTGAGC TGCCTGGAGG AGGAACGGCT GCTGTTGGTG GTGACCAGTA CGTTTGGCAA TGGAGACTGC CCTGGCAATG GAGAGAAACT GAAGAAATCG CTCTTCATGC TGAAAGAGCT CAACAACAAA TTCAGGTACG CTGTGTTTGG CCTCGGCTCC AGCATGTACC CTCGGTTCTG CGCCTTTGCT CATGACATTG ATCAGAAGCT GTCCCACCTG GGGGCCTCTC AGCTCACCCC GATGGGAGAA GGGGATGAGC TCAGTGGGCA GGAGGACGCC TTCCGCAGCT GGGCCGTGCA AACCTTCAAG GCAGCCTGTG AGACGTTTGA TGTCCGAGGC AAACAGCACA TTCAGATCCC CAAGCTCTAC ACCTCCAATG TGACCTGGGA CCCGCACCAC TACAGGCTCG TGCAGGACTC ACAGCCTTTG GACCTCAGCA AAGCCCTCAG CAGCATGCAT GCCAAGAACG TGTTCACCAT GAGGCTCAAA TCTCGGCAGA ATCTACAAAG TCCGACATCC AGCCGTGCCA CCATCCTGGT GGAACTCTCC TGTGAGGATG GCCAAGGCCT GAACTACCTG CCGGGGGAGC ACCTTGGGGT TTGCCCAGGC AACCAGCCGG CCCTGGTCCA AGGCATCCTG GAGCGAGTGG TGGATGGCCC CACACCCCAC CAGACAGTGC GCCTGGAGGA CCTGGATGAG AGTGGCAGCT ACTGGGTCAG TGACAAGAGG CTGCCCCCCT GCTCACTCAG CCAGGCCCTC ACCTACTCCC CGGACATCAC CACACCCCCA ACCCAGCTGC TGCTCCAAAA GCTGGCCCAG GTGGCCACAG AAGAGCCTGA GAGACAGAGG CTGGAGGCCC TGTGCCAGCC CTCAGAGTAC AGCAAGTGGA AGTTCACCAA CAGCCCCACA TTCCTGGAGG TGCTAGAGGA GTTCCCGTCC CTGCGGGTGT CTGCTGGCTT CCTGCTTTCC CAGCTCCCCA TTCTGAAGCC CAGGTTCTAC TCCATCAGCT CCTCCCGGGA TCACACGCCC ACGGAGATCC ACCTGACTGT GGCCGTGGTC ACCTACCACA CCGGAGATGG CCAGGGTCCC CTGCACCACG GTGTCTGCAG CACATGGCTC AACAGCCTGA AGCCCCAAGA CCCAGTGCCC TGCTTTGTGC GGAATGCCAG CGCCTTCCAC CTCCCCGAGG ATCCCTCCCA TCCTTGCATC CTCATCGGGC CTGGCACAGG CATCGTGCCC TTCCGCAGTT TCTGGCAGCA ACGGCTCCAT GACTCCCAGC ACAAGGGAGT GCGGGGAGGC CGCATGACCT TGGTGTTTGG GTGCCGCCGC CCAGATGAGG ACCACATCTA CCAGGAGGAG ATGCTGGAGA TGGCCCAGAA GGGGGTGCTG CATGCGGTGC ACACAGCCTA TTCCCGCCTG CCTGGCAAGC CCAAGGTCTA TGTTCAGGAC ATCCTGCGGC AGCAGCTGGC CAGCGAGGTG CTCCGTGTGC TCCACAAGGA GCCAGGCCAC CTCTATGTTT GCGGGGATGT GCGCATGGCC CGGGACGTGG CCCACACCCT GAAGCAGCTG GTGGCTGCCA AGCTGAAATT GAATGAGGAG CAGGTCGAGG ACTATTTCTT TCAGCTCAAG AGCCAGAAGC GCTATCACGA AGATATCTTC GGTGCTGTAT TTCCTTACGA GGCGAAGAAG GACAGGGTGG CGGTGCAGCC CAGCAGCCTG GAGATGTCAG CGCTCTGAGG GCCTACAGGA GGGGTTAAAG CTGCCGGCAC AGAACTTAAG GATGGAGCCA GCTCTGCATT ATCTGAGGTC ACAGGGCCTG GGGAGATGGA GGAAAGTGAT ATCCCCCAGC CTCAAGTCTT ATTTCCTCAA CGTTGCTCCC CATCAAGCCC TTTACTTGAC CTCCTAACAA GTAGCACCCT GGATTGATCG GAGCCTCCTC TCTCAAACTG GGGCCTCCCT GGTCCCTTGG AGACAAAATC TTAAATGCCA GGCCTGGCGA GTGGGTGAAA GATGGAACTT GCTGCTGAGT GCACCACTTC AAGTGACCAC CAGGAGGTGC TATCGCACCA CTGTGTATTT AACTGCCTTG TGTACAGTTA TTTATGCCTC TGTATTTAAA AAACTAACAC CCAGTCTGTT CCCCATGGCC ACTTGGGTCT TCCCTGTATG ATTCCTTGAT GGAGATATTT ACATGAATTG CATTTTACTT TAATC GAATTCCCAC

TCTGCTGCCT GCTCCAGCAG ACGGACGCAC AGTAACATGG GCAACTTGAA GAGCGTGGCC CAGGAGCCTG GGCCACCCTG CGGCCTGGGG CTGGGGCTGG GCCTTGGGCT GTGCGGCAAG CAGGGCCCAG CCACCCCGGC CCCTGAGCCC AGCCGGGCCC CAGCATCCCT ACTCCCACCA GCGCCAGAAC ACAGCCCCCC GAGCTCCCCG CTAACCCAGC CCCCAGAGGG GCCCAAGTTC CCTCGTGTGA AGAACTGGGA GGTGGGGAGC ATCACCTATG ACACCCTCAG CGCCCAGGCG CAGCAGGATG GGCCCTGCAC CCCAAGACGC TGCCTGGGCT CCCTGGTATT TCCACGGAAA CTACAGGGCC GGCCCTCCCC CGGCCCCCCG GCCCCTGAGC AGCTGCTGAG TCAGGCCCGG GACTTCATCA ACCAGTACTA CAGCTCCATT AAGAGGAGCG GCTCCCAGGC CCACGAACAG CGGCTTCAAG AGGTGGAAGC CGAGGTGGCA GCCACAGGCA CCTACCAGCT TAGGGAGAGC GAGCTGGTGT TCGGGGCTAA GCAGGCCTGG CGCAACGCTC CCCGCTGCGT GGGCCGGATC CAGTGGGGGA AGCTGCAGGT GTTCGATGCC CGGGACTGCA GGTCTGCACA GGAAATGTTC ACCTACATCT GCAACCACAT CAAGTATGCC ACCAACCGGG GCAACCTTCG CTCGGCCATC ACAGTGTTCC CGCAGCGCTG CCCTGGCCGA GGAGACTTCC GAATCTGGAA CAGCCAGCTG GTGCGCTACG CGGGCTACCG GCAGCAGGAC GGCTCTGTGC GGGGGGACCC AGCCAACGTG GAGATCACCG AGCTCTGCAT TCAGCACGGC TGGACCCCAG GAAACGGTCG CTTCGACGTG CTGCCCCTGC TGCTGCAGGC CCCAGATGAG CCCCCAGAAC TCTTCCTTCT GCCCCCCGAG CTGGTCCTTG AGGTGCCCCT GGAGCACCCC ACGCTGGAGT GGTTTGCAGC CCTGGGCCTG CGCTGGTACG CCCTCCCGGC AGTGTCCAAC ATGCTGCTGG AAATTGGGGG CCTGGAGTTC CCCGCAGCCC CCTTCAGTGG CTGGTACATG AGCACTGAGA TCGGCACGAG GAACCTGTGT GACCCTCACC GCTACAACAT CCTGGAGGAT GTGGCTGTCT GCATGGACCT GGATACCCGG EPI-109 44

ACCACCTCGT CCCTGTGGAA AGACAAGGCA GCAGTGGAAA TCAACGTGGC CGTGCTGCAC AGTTACCAGC TAGCCAAAGT CACCATCGTG GACCACCACG CCGCCACGGC CTCTTTCATG AAGCACCTGG AGAATGAGCA GAAGGCCAGG GGGGGCTGCC CTGCAGACTG GGCCTGGATC GTGCCCCCCA TCTCGGGCAG CCTCACTCCT GTTTTCCATC AGGAGATGGT CAACTATTTC CTGTCCCCGG CCTTCCGCTA CCAGCCAGAC CCCTGGAAGG GGAGTGCCGC CAAGGGCACC GGCATCACCA GGAAGAAGAC CTTTAAAGAA GTGGCCAACG CCGTGAAGAT CTCCGCCTCG CTCATGGGCA CGGTGATGGC GAAGCGAGTG AAGGCGACAA TCCTGTATGG CTCCGAGACC GGCCGGGCCC AGAGCTACGC ACAGCAGCTG GGGAGACTCT TCCGGAAGGC TTTTGATCCC CGGGTCCTGT GTATGGATGA GTATGACGTG GTGTCCCTCG AACACGAGAC GCTGGTGCTG GTGGTAACCA GCACATTTGG GAATGGGGAT CCCCCGGAGA ATGGAGAGAG CTTTGCAGCT GCCCTGATGG AGATGTCCGG CCCCTACAAC AGCTCCCCTC GGCCGGAACA GCACAAGAGT TATAAGATCC GCTTCAACAG CATCTCCTGC TCAGACCCAC TGGTGTCCTC TTGGCGGCGG AAGAGGAAGG AGTCCAGTAA CACAGACAGT GCAGGGGCCC TGGGCACCCT CAGGTTCTGT GTGTTCGGGC TCGGCTCCCG GGCATACCCC CACTTCTGCG CCTTTGCTCG TGCCGTGGAC ACACGGCTGG AGGAACTGGG CGGGGAGCGG CTGCTGCAGC TGGGCCAGGG CGACGAGCTG TGCGGCCAGG AGGAGGCCTT CCGAGGCTGG GCCCAGGCTG CCTTCCAGGC CGCCTGTGAG ACCTTCTGTG TGGGAGAGGA TGCCAAGGCC GCCGCCCGAG ACATCTTCAG CCCCAAACGG AGCTGGAAGC GCCAGAGGTA CCGGCTGAGC GCCCAGGCCG AGGGCCTGCA GTTGCTGCCA GGTCTGATCC ACGTGCACAG GCGGAAGATG TTCCAGGCTA CAATCCGCTC AGTGGAAAAC CTGCAAAGCA GCAAGTCCAC GAGGGCCACC ATCCTGGTGC GCCTGGACAC CGGAGGCCAG GAGGGGCTGC AGTACCAGCC GGGGGACCAC ATAGGTGTCT GCCCGCCCAA CCGGCCCGGC CTTGTGGAGG CGCTGCTGAG CCGCGTGGAG GACCCGCCGG CGCCCACTGA GCCCGTGGCA GTAGAGCAGC TGGAGAAGGG CAGCCCTGGT GGCCCTCCCC CCGGCTGGGT GCGGGACCCC CGGCTGCCCC CGTGCACGCT GCGCCAGGCT CTCACCTTCT TCCTGGACAT CACCTCCCCA CCCAGCCCTC AGCTCTTGCG GCTGCTCAGC ACCTTGGCAG AAGAGCCCAG GGAACAGCAG GAGCTGGAGG CCCTCAGCCA GGATCCCCGA CGCTACGAGG AGTGGAAGTG GTTCCGCTGC CCCACGCTGC TGGAGGTGCT GGAGCAGTTC CCGTCGGTGG CGCTGCCTGC CCCACTGCTC CTCACCCAGC TGCCTCTGCT CCAGCCCCGG TACTACTCAG TCAGCTCGGC ACCCAGCACC CACCCAGGAG AGATCCACCT CACTGTAGCT GTGCTGGCAT ACAGGACTCA GGATGGGCTG GGCCCCCTGC ACTATGGAGT CTGCTCCACG TGGCTAAGCC AGCTCAAGCC CGGAGACCCT GTGCCCTGCT TCATCCGGGG GGCTCCCTCC TTCCGGCTGC CACCCGATCC CAGCTTGCCC TGCATCCTGG TGGGTCCAGG CACTGGCATT GCCCCCTTCC GGGGATTCTG GCAGGAGCGG CTGCATGACA TTGAGAGCAA AGGGCTGCAG CCCACTCCCA TGACTTTGGT GTTCGGCTGC CGATGCTCCC AACTTGACCA TCTCTACCGC GACGAGGTGC AGAACGCCCA GCAGCGCGGG GTGTTTGGCC GAGTCCTCAC CGCCTTCTCC CGGGAACCTG ACAACCCCAA GACCTACGTG CAGGACATCC TGAGGACGGA GCTGGCTGCG GAGGTGCACC GCGTGCTGTG CCTCGAGCGG GGCCACATGT TTGTCTGCGG CGATGTTACC ATGGCAACCA ACGTCCTGCA GACCGTGCAG CGCATCCTGG CGACGGAGGG CGACATGGAG CTGGACGAGG CCGGCGACGT CATCGGCGTG CTGCGGGATC AGCAACGCTA CCACGAAGAC ATTTTCGGGC TCACGCTGCG CACCCAGGAG GTGACAAGCC GCATACGCAC CCAGAGCTTT TCCTTGCAGG AGCGTCAGTT GCGGGGCGCA GTGCCCTGGG CGTTCGACCC TCCCGGCTCA GACACCAACA GCCCCTGAGA GCCGCCTGGC TTTCCCTTCC AGTTCCGGGA GAGCGGCTGC CCGACTCAGG TCCGCCCGAC CAGGATCAGC CCCGCTCCTC CCCTCTTGAG GTGGTGCCTT CTCACATCTG TCCAGAGGCT GCAAGGATTC AGCATTATTC CTCCAGGAAG GAGCAAAACG CCTCTTTTCC CTCTCTAGGC CTGTTGCCTC GGGCCTGGGT CCGCCTTAAT CTGGAAGGCC CCTCCCAGCA GCGGTACCCC AGGGCCTACT GCCACCCGCT TCCTGTTTCT TAGTCCGAAT GTTAGATTCC TCTTGCCTCT CTCAGGAGTA TCTTACCTGT AAAGTCTAAT CTCTAAATCA AGTATTTATT ATTGAAGATT TACCATAAGG GACTGTGCCA GATGTTAGGA GAACTACTAA AGTGCCTACC CCAGCTC-3' (SEQ. ID NO:2410)

Human Factor Related Anti-sense Oligonucleotide

5'-CCT CCT TCC TGG TCT GTC TGC CBG BCB BBT TTG GGB BGT GBB CBG TTT TGG BBC CBT GTT TCC CBG TCT CTG BGC TGT GGC GCC CTG CTG CTC TTT CTG CT TCC CTT GGT GGG TTG GGC C GCT GGT TGT TCT GGG GTT C TTG CTG CCC CTT CTG TCC C TGT TTG CTG GTG TCT GCG C CCC CBB CBG BBG BBG CBG BCB BBT TTG GGB BGT GBB CBG TTT TGG BBC CBT GTT TCC TGT GCG CTC GGC CTG GTC CCG G GGG TCT CCT CTT GTT GTT GC TTG CGC CTC CTG CTG GGG GT CC CTC TGT TCT TGT TTT GGG GGC GGG CCC GGC CGT TGT CTT G GTT TGG GGG TTT CCG TTG GGG TTC TCC TGG CCC GGG CCT TGC CC GGC CGT GGT CCC GGC TTC GTTCCT GTC TCC GTC TCG GCT CTT CTG GGG CCT TGC GCT GTC TTT GGT G GCB CCG TCC BGT GBT GGT GCG GTB CTT GTC GCT GCB GCG CTC GGC CTG GTC CCG GBG BGC GCG CGG GCC GGG GGC TGC TGG G GGT TGG CCC GGG GTG CCC C GCC GCT GGG TGC CCT CGT CCT CTG CGG TC GTG TCT CCT GGC TCT GGT TCC CC GCT GCG CCC GTT GTC CTC TGG GGT GGC CTT C GCT CCC GGG TCT GGT TCT TGT GT TGG GGG TCC CTT TTT GGG CCT GTT GT GGC GTG GCT TGT GTG TTC GGT TTC TGC CCT GTC CTC CGG CGT CCC CGG BGC CTC CCC GGG GCB GGB TGB CTT TTG BGG GGG BCB CBG BTG TCT GGG CBT TGC CBG GTC CTG GGB BCB GBG CCC CGB GCB GGB CCB GGB GTG CGG GCB GCG CGG GCC GGG GGC TGC TGG GBG CCB TBG CGB GGC TGB G CCT CTT TTC TGT TTT TCC C CTC TGC CTT TGT TTG GGT TCG CTT CCT TTC TGC TTC TTC C CTG TGT CTC CTG TCT CCG CTT TTT TCT TC GTC TTT GTT GTT TTC TCT TCC TTG CTG BGC BBG BTB TCT BGB TTC TGG GGT GGT CTC GBT TTT BBBB GCT TGB GBB GCT GCB BBC BTT BTC CBB BGT BTB TTT GBG GCT CCB BGG BTC BCG BCC BTC TTC CCB GGC BTT TTB BGT TGC TGT CGT BBG TGB GBG CTG BGB GBB BCT GTG BBG CBB TCB TGB CTT CBB GBG TTC TTT TCB CCC GTT CTT GGC TTC TTC TGT C CGT TGG CTT CTC GTT GTC CC TGT GGG CTT CTC GTT GTC CC CCC TTC GGG GGC TGG TGG GGC CGT CCT TGC CTG CTG G GTT CTT GGC TTC TTC TGT CCG T TGG CTT CTC GTT GTC CC TGT GGG CTT CTC GTT GTC CC CCC TTC GGG GGC TGG TGG GGC CGT CCT TGC CTG CTG G TTT TCT CTT TCG CTT TCT TTT CGT CTC CTG TTC CTC CTT TT TTG CTG TTT TTT CTC CTT CTT CTC TCC TTT CTT TTC TTT TCT CTT TCG CTT TCT TTT CGT CTC CTG TTC CTC CTT TT TTG CTG TTT TTT CTC CTT CTT CTC TCC TTT CTT TTC CTC TGT CTT GTT CTG GTC CTT CGT GGG GCT CTG TGT CGC GTG G GTG CGG CCG TGG CC GGC GGB CCB GGB GTT GGB GCB GGB GCB GGB CGG GCB GGC GGC TCB TGT TTG GBT CGG CBG GBG GCB CTC CTC TGG TTG GCT TCC TTC GCC GGC BCB TGC TBG CBG GBB GBB CBG BGG GGG BBG CBG TTG GGB GGT GBG BCC CBT TBB TBG GTG TCG B TCCCTGTTTC CCCCCTTTCG TTCTGCGTTT GCCTTTGGCG TTTTTTGTTT GTTTTCTCTC TCCGTCTTTC TTCTCCCCT GTGGGBBTTT CTGTGGGGBT GGCBTBCBCG TBGGCBGCTC CBBGBGCTBG CBBBCTCBBB TGCBGBBGCB TCCTCBTGGC TCTGBBBCGG TGGGAATTTC TGTGGGGBTG GCATACACGT AGGCAGCTCC AAGAGCTAGC AAACTCAAAT GCAGAAGCATC CTCATGGCTC TGAAACG GGGGGTGGCT TCCTGCCGCG TCTCTGGGCC GTCCCGTCCC TCGGCCCCGC GCCGCGCTCG GCTCCTCTCC CTCTGGCCCG GCTCGGGGCG GGGCGGGGCG GTGGGCGGGC GGCGCTGCCC TGCGCGCGGC GCTGGCCCCT GCTGGCCGTC GGCTGCGCGC TGCTGGCTGC CCTGCTGGCC GCGCCGGGGC CTGTCCGCCT CTGCGGGCGC TGTCTCCTGG CTTGTCTTCC GGCTCTTCTG CTGGGGTGGG GCTGGGCGGC t i-109 45

CGGCCCGGTG CTGGGGCTCC TCGGGGGGGG GGGCTCTTCC GGGCTGTCTC CCTCCGGGGC GGGGGTTTCT GGCCGTGGGG GTCTTGCCTG GCCTCCGGGC TCCTGCTTGT CTTGCCTTCC TTCTCTGGTC GGTTGTGGCT CGGGGCTCCG TGGGTCCCTG GCGCCCGTTT GTGTTTTGTC TTTTCCCCTG GCGTCCCTGT GCCCCTCTCC TCTCCTTCCT CTGCTTCTCG CTCTCCTTTG TGGGGCCCTC CCTGCTGCTC TTGGTTTTGG GCTTTTTTTC TCTTCCTCCT TTTTCGTGCG TGGGCCTCC GCACGCCTCT TGCCACCTCC TGCGCAGGGC AGCGCCTTGG GGCCAGCGCC GCTCCCGGCG CGGCCAGCAG GGCAGCCAGC AGCGCGCAGC CGACGGCCAG CATGCTTCCT CCTCGGCTAC CACTCCATGG TCCCGCAGAG GCGGACAGGC GCBCGCCTC TTGCCBCCTC CTGCGCBGGG CBGCGCCTTG GGGCCBGCGC CGCTCCCGGC GCGGCCBGCB GGGCBGCCBG CBGCGCGCBG CCGBCGGCCB GCBTGCTTCC TCCTCGGCTB CCBCTCCBTG GTCCCGCBGB GGCGGBCBGG C GGGGTGGBBB GGTTTGGBGT BTGTCTTTBT GCBCTGBCBT CTBBGTTCTT TBGCBCTCCT TGGCBBBBCT GCBCCTTCBC BCBGBGCTGC BGBBBTCBGG BBGGCTGCCB BGBGBGCCBC GGCCBGCTTG GBBGTCBTGT TTBCBCBCBG TGBGBTGGTT CCTTCCGGGC TTGTGTGCTC TGCTGTCTCT TGGTTCCTTC CGGTGGTTTC TTCCTGGCTC TTGTCCTTTC TCTTGG CCCT TGGC CGGGBGTGGG GGTCCTGGBC GGCBCTGBBG GCBTCCBGGG CTCCCTTCCB GTCCTTCTTG TCCGCTGCCB GCBCCCCTTC BTTCCBGBGG CTGBTGGCCT CCBCCBGGGB CBTGBTTBGG TBGBBBCTBG GBGGCCGGCC TCCBCCBGGG BCBTGGTCCT TCTTGTCCGC TGCCTCTCTG GGGTTTTCGG TCTGGGTGGG CTTTCCTCCT GGGGCTGCTG CTGGGCTCTT CTTTTTGTTT CTGGCCTGGT GCTCTCTCGT GCCCTTTCCC TTGGGTGTCT TGTTTTTGTG GCCTCCBCCB GGGBCBTG GTCTTTGTTT CTGGGCTCGT GCCCCBTCCC GGCTTCTCTC TGGTTCCGTC CTCTGTGGTG TTTGGCCCTG CTTCCTTTTG CCTGTTGAGG GGGCAGCAGT TGGGCCCCAA AGGCCCTCTC GTTCACCTTC TGGCACGGAGTT GCATCCCCATA GTCAAACTCT GTGGTCGTGT CATAGTCCTC TGTGGTGTTT GGAGTTTCCA TCCCGGCTTC TCTCTGGTTC CAAGGGAGB GGGGGCBGCB GTTGGGCCCC BBBGGCCCTC TCGTTCBCCT TCTGGCBCGG BGTTGCBTCC CCBTBGTCBB BCTCTGTGGT CGTGTCBTBG TCCTCTGTGG TGTTTGGBGT TTCCBTCCCG GCTTCTCTCT GGTTCCBBGG GB GGGCBCGGGG CBGTGGGCGG GCBBTGTBGG CBBBGCBGCB GGGTGTGGTG TCCGBGGBBT BTGGGGBGGC BGBTGCBGGB GCGCBGBGGG CBGTBGCBBT GBGGBTGBCB GCGBGGCGTG CCGCGGBGBC CTTCBTGGTB CCTGTGGBGB GGCTGTCGGB GGGGGTGTGG TGTCCGCTTG GCGGTTCTTT CGGGTGTTTC TTCTCTGGGT TGGCCTGCTG CTCGTCGTGGT CGCTCCGCTC CCGGGTTCGT CTCGCTCTGT CGCCCCTTCC TTCCTTGTCG TGTTCCTCCC TTCCTTGCCT CT GBTGTTTGTT BCCBBBGCBT CBBGBBTBGC TTTGCTBTCT BBGGBTCBCB TTTBGBCBTB GGBBBBCGCT GTBGGTCBGBB BGBTGTGCTT BCCTTCBCBC BGBGCTGCBG BBBTCBGGBBGG CTGCCBBGBGBG CCBCGGCCBGC TTGGBGTCBT GTTTBCBCBC BGTGBGGTGC TCCGGTGGCT TTTTGCTTGT GTGCTCTGCT GTCTCTG TTC CTTCCGGTGG TTTCTTCCTG GCTCTTGTCC TTTCTCTTGG CCCTTGGCCC CTTGBGCBGG BBGCTCTGGG GCBGGGBGCT GGCBGGGCCC BGGGGGGTGG CTTCCTGCBC TGTCCBGBGT GCBCTGTGCC BCBGCBGCBG CTGCBGGGCC BTCBGCTTCB TGGGGCTCTG GGTGGCBGGT CCBGCCBTGG GTCTGGGTGG GGCTGGGCTG CBGGCTCCGG GCGGTCCBGCCBTGGGTCTG GGGGCTGGG CTGCBGGCTC CGGGCGGGCG GGTGCGGGCT GCGTGCTGGG GGCTGCCCCG CAGGCCCTGC GGTCCBGCCB TGGGTCTGGG GGCTGGGCTG CBGGCTCCGG GCGGGCGGGT GCGGGCTGCG TGCTGGGGGC TGCCCCGCAG GCCCTGC GCBCCGCCTG GBGCCCTGGG GCCCCCCTGT CTTCTTGGGG BGCGCCTCCT CGGCCBGCTC CBCGTCCCGG BTCBTGCTTT CBGTGCTCBT GGTGTCCTTT CCBGGGGBGB GBGGGGCTGG TCCTCTGCTG TCCTTGCTGG TGCTCBTGGT GTCCTTTCCG CCCTGGGGCC CCCCTGTCTT CTTGGGGCCT CTTCCCTCTG GGGGCCGTCT CTCTCCCTCT CTTGCGTCTC TCTCTTTCTC TCTCTCTCTT CCCCTTTCCC GCTCTTTCTG TCTCGGTGTC TGGTTTTCTC TCTCCGCTGG CTGCCTGTCT GGCCTGCGCT CTTGGCCTGT GCTGTTCCTC CTCCGGTTCC TGTCCTCTCT GTCTGTCGCC CCCTCTGGGG TCTCCCTCTG GGTGGTGGTC TTGTTGCTTG GGCTGGGCTC CGTGTCTCCB GTGCTCBTGG TGTCCGCTGB GGGBGCGTCT GCTGGCGCTG GTCCTCTGCTGTC CTTGCTGGTG CTCBTGGTGT CCTTTCCGCC CTGGGGCCCC CCTGTCTTCT TGGGGCCTCT TCCCTCTGGG GGCCGTCTC TCTCCCTCTC TTGCGTCTCT CTCTTTCTCT CTCTCTCTTC CCCTTTCCCG CTCTTTCTGT CTCGGTGTCT GGTTTTCTCT CTCCGCTGGC TGCCTGTCTG GCCTGCGCTC TTGGCCTGTG CTGTTCCTCC TCCGGTTCCT GTCCTCTCTG TCTGTCGCCC CCTCTGGGGT CTCCCTCTGG CGTGGTGGTC TTGTTGCTTG GGCTGGGCTC CGTGTCTCCB GTGCTCBTGG TGTCCGCTGB GGGBGCGTCT GCTGGC CTGCTGBGGC TTGGGTCTCC GGGCGBTTCT CTGCBGBBGB TGCTCBBBGG GCTCCGGCBG TTCCTCCTTG BTCTGGTCGCT GTCGTBCCBG TCGGBCCBGT BBTTCBGBTC BTCBTTGGCT CCTBTTTCTT CTGCBBBCBG CTGBGTGGBG BCBBGBBBBB BGBCTGCCBB GGCCBCGBGG BTTTTCBTGT TGGBTTTTGC GBCGGBCBGT CCCGCGGGGT GCTGAGTTTC TCTGGTTCCT CCGBGCGCBC GTGGTCGCTC CGCGTTTCTC TGGTTCCTCC GGTCCCGCGG GGTGCTGTCT GGTCGCTGTC GTGGCTTGGG TCTCCGGGCG GTTTCCTTCC TTTTCCGC CGGCCCTTCT CACTGGAGGC ACCGGGCAGT CCTCCATGGG AGGGTTGGGC TTGGCCGGGG CTGCCCGGTG CCTCCTCTTG GCTGGTCCCT CGTTGTCCTT GGGCCCCGC TCCCGCTGCT CGGCCTCCGT GTTCTTTGGC CTCTTGCTCC GCCTGCTGTC TTGTCCCGTC CCCTCCTCGC TTGCGTTTCC CTCTTCCTTG TCTTCCAGGC CTTCCTCCGC TTCCGCTGCT GGGGCCCGCG CCGGGGGGGC GCTCGGCTCC GCGGCTTCCT CCCCGGCTGG GGGGTCCTGG TCTCCGGGGC CTGCGGCTCG CGGGCTCGGG GCTGCGTGCG CCGCGCGCGG CGTCCGCGGT GGGTGGCGCT GTCCCGCCGT GGTGTGTCTC CGTTCTCGTC CTGCGCCGTC CTGGTCTGCC CGTGGGGTCC TGGGCGTGGT GGGGGGCGTC TGGTGCCTCG TCTGCCCCGT GGGGCTTCGG GCTCGGGGCT GTTCGTCCCC CCTGCCGCTC TGTGGCCTCC GGGGCTCCTC GTTTTCGCTG CTTCGGGTGT CCTTCTCGGC GTGTGGCCCC GGGTCCCGGC CCTGCTGGGC TGGGCGGGGT CGCTGCCCTG GGCTTCTGGC CCGTCTGGTT GTCTGTCGGT GCTTGTCTCG GGTTTCTGGC CTCTGTGCTG GGCGCTTCTC TGCCTCCTGC TCCGCCCTCC TGGTGGCTCG GCTGGGGGTG CCCGTGCGGG GGTGGGTGTG GGGTGTTTTC GGGGTCCTCC CCTTCCC GTT TCA TCT TGG CTT TAT CCTCT CCC CTT GTT CCT CCC CTCT CCT GCT CTG GRG TCT CCT C TTC CCT CCC TCC CCT GCC GTG TTG TCT GTG GGT GTC GTT TCG CTC TTG TTG CCC TGG GCC CTT CCC TGC TGG GGG GGA GTT TCA TCT TGG GTT TCB TCT TGG CTT TBT CCTCT CCC CTT GTT CCT CCC CTCT CCT GCT CTG GRG TCT CCT C TTC CCT CCC TCC CCT GCC GTG TTG TCT GTG GGT GTC GTT TCG CTC TTG TTG CCC TGG GCC CTT CCC TGC TGG GGG GGB GTT TCB TCT TGG GGG GGB GTT TCB TCT TGG CTT T CCGTGTTGTC BGTGGTGCTG CCCGTTTGBG GTBTGGCGCT CCBCCBBTTC CCTTTTCTCC TTGTTTTCCG TTTCTCTTGC CGTCTGTGGT T GCTCAGCCTC CAAAGGAGCC AGCCTCTCCC CAGTTCCTGA AATCCTGAGT GTTGCCTGCC AGTCGCCATG AGAACTTCCT ACCTTCTGCT GTTTACTCTC TGCTTACTTT TGTCTGAGAT GGCCTCAGGT GGTAACTTTC TCACAGGCCT TGGCCACAGA TCTGATCATT ACAATTGCGT CAGCAGTGGA GGGCAATGTC TCTATTCTGC CTGCCCGATC TTTACCAAAA TTCAAGGCAC CTGTTACAGA GGGAAGGCCA AGTGCTGCAA GTGAGCTGGG AGTGACCAGA AGAAATGACG CAGAAGTGAA ATGAACTTTT TATAAGCATT CTTTTAATAA AGGAAAATTG CTTTTGAAGT AT ATCCTTTAAG TCAATGGACT TTGCATCAGT CACACCATCT TTTGTTACTT TGGACTTCCC CAGCTATGTT CAATAATTAC TGTTCTTCCC TTGGGCCCCA TTGTAATGGC TACAGCCTCG ACAAAAAGTC TACACTTTGA AGCATTAAGG CTCGGACATC AGCACCAAAT TTTACATCTT TACCATCACT TCAAGTGAGG TGAGGAGCCA GTAGCCTGGA CACTGGTCTC ATCTGGTGAA AGACTGTGGG TAATGGAAGC ATTTCTGTGG GGTGCTGGCA GGACATGTGC ATGGCGAGGC AGGTCATCAG EPI-109 46

CAGCAAGTGA GAGCTGCCTC TTACTTTCTA AAGGTGACAT AGCAAATATA CAAAAAAAAA TAAATAAATT ATTAATTTAG GTAGAGCACA TAAAGGCTTT ATTTCATATT CCATTTCTCT GTATGCTTTC TTCACCAGGA AGAAATAGTT TTAGTGTCAG GAATGAATGA GTCTGCCCCT CAATTCCAGC CTGCTCAACA CACAAGGAAA CAAAGCCCTG ACAATCAGAG TGACTCCCTG GTGACTAAGC TCCCAGTCCT GGATGCATAT TTGTTTAGCA GTTCTGACAG CATTTGACCC AGCCCTCTCT CTGCATATCC CATCAGAACC TTCTTTTTTT TTTTTTTCTT TGAGACTGAG TCTTGCTCTG TCGGAAGCGA CTCCTGTGCC TCAGCCTCCC AAATACCTGG AATTATAGGC GTAAGCCATC ATGCCTGGCT AATTTTTGTA TTTTTCATGG AGATGGGGTT TTGCCATGTT GGTCAAATTG GTCTCACACT CCTGACCTCA TGTGATCCAC CTGCCTCAGC CTCCCAAACT GCTGGGATGA CAGGTGTAAG CCACCATGCT AGGCTCAGAA ATTTCCTTTT ATAAAAATGT CATTAAGGAT CTTGGCTGCA CAATATCGTT ACCAGCTTCC TTTAAATCCA CTTCTGGCCT GCCAGGAATC AGGTTCTTCA GAACCTGACA TTTTAAATGA AGAGGTCAGG CAGTTCATGA GGAAAGCCTC ATTGTCCCCA TGTCTCTGTC ACTGCTGCAC CCCTGAGACA TCACAGACAT GGACACTGGG GCCTGCTTGT TTCTCAAACT GCCCTTAGAT CGAAAGAGGG AGGAACCAGG ATGAATGCCA CTCATTTTCC CAAGAAAGGC CCTCTCCTGA GTGCCCGGGA TGGGGCTCTG TCCATTGCCT GGGGCCGCCA ATTGCTACTC TGGGTTACGG AGGAAGGACA GGGTCCTGAG AGACACCAGA GACCTCACAC AGCCCTGAAA ACATGGGGCT CCTTCATAAG TGTTTCCCAT CACCAACAGG GAGACCACGT GGAGGCCTTG CAGCCCCACT CGGTGCTTCT CCACCAAATC CCAAGGGCAG TGACGCTGAC GTCTGTGGAA AGCAGAGAAA GCCCTGGCTC CCAAAGCCCT GAAGTCCCTG TGGAGCTGAC ATTCCCTGAG TGACGGTGTG AATGGAAGGA ACTCAAGTGC GGGTGGTAGG CCACCTCCTG GCCCAGGCCT GGGTGAACTC TGAGGGGACA CATGTAGTCA CAATCCCATC CTCCCATTCT CCTTCTCAGA GGAAGGAAGT GGGCATCCAT CTGCCTCATC TCTCTCCCGT GGGGAAGATG GGGAGTTTCA GGGGAACTTT CACATAAATT TCACCAGCTC AGATCTCCTG TGAGGATGGG GCCCACCATG CTCCCGGTGC TGCCAGAGGC CCTGAGCCCC TCCCAGGGTC CCTGGGTTTG AGCCAGCCCT GTATCATCCC CAGGAGCTGA ATGTCAGAGC AATGGATAGA ATTAGATGGA AAGAGCTCTC AATTTGACCT GAGACTGTCC CCAGATACTC AGGAAAAACA GGACGTCGCA CAGAGTGGGC AGCAGGTGAG TGGCAGGTTA TAGGTCCTGA GTTTGAGTTT GTTCTCACGT GAGACAGACC CAGCCCCTCA CTCCATTCAC ACACTGGGTT TTAAATGGTG CAAGATAGGA GCAATTTTCT GGTCCCAAGA GCAGGAGGAA GGGATTTTCT GGGGTTTCCT GAGTCCAGAT TTGCATAAGA TCTCCTGAGT GTGCATTGTT CTTTGAGGAC CATTCTCTGA CTCACCAGGT AAGTGGCTGA ATTCTAACCT CTGTAATGAG CATTGCACCC AATACCAGTT CTGAACTCTA CCTGGTGACC AGGGACCAGG ACCTTTATAA GGTGGAAGGC TTGATGTCCT CCCCAGACTC AGCTCCTGGT GAAGCTCCCA GCCATCAGCC ATGAGGGTCT TGTATCTCCT CTTCTCGTTC CTCTTCATAT TCCTGATGCC TCTTCCAGGT GAGATGGGCC AGGGAAATAG GAGGGTTGGC CAAATGGAAG AATGGCGTAG AAGTTCTCTG TCTCCTCTCA TTCCCCTCCA CCTATCTCTC CCTCATCCCT CTCTCTCCTT CCTCTCTCTG TGTGTCCCCT CCATCCTTTT CTCCTGCTTC TCTCTCTTCT TCCCTCTCTC TCTTTTTTCT GTCTTTCTTT TTCCTCTCTC CCTAGAGCAT GTCTTTCTTT CTTTCTCTTT CCTTTCTTCT ACCCACACTT TTAGACTGAA TGCCCTATTT AATTGAACAA AGCATTGCTT CCTTCAATAG AAAAGGAGTT TGAGAACCCA ATGGACACCT CACTCGTTCT TCTAAGCCAA TATGAAGGAG CCCAGTAGCT TGTAAATATC ATCTCTTCAC TGCTTTCCAT GCTACAACTG CTGAGACTAT GGTTGAAACC TGTTAGGTGA CTTTTTAAAT AAAAGGCAGA AATTTTGATT TTATCTAAAG AAAGTAGTAT AGAATGTCAT TTTCTAAATT TTTATATTTA AAGGGTAGAT ACTGCAACCT AGAGAATTCC AGATAATCTT AAGGCCCAGC CTATACTGTG AGAACTACTG CAGCAAGACA CTCTGCCTCC AGGACTTTTC TGATCAGAGG CCCTGAGAAC AGTCCCTGCC ACTAGGCCAC TGCAGGTTCA CAGGACAGGG TACAGCCCAT TGAAACCTAC TTTTAAACCT GGATGCCTAA CCTTCATTTT CTCCTTGATA TTATGAAAAT AAAATAAAAA CCATGAAAGG ATAAAAGAGG GAGAGTGGAA GGGAAGGATG GAGAAAGGGA AAAAGAAAAT TTGAGAGTAA ATCCTAAAAC AATTAATCTA ATAGATATCA TCTTGTGAAA TCCTCATTTT ACCAATCTTA TTTATGAGTC CTGGGTTTTG TGAGAACAAT GGGGTTCTGA GAGGCACCAG AGACCTCATG TTTTCCAAAA CCTAGAACAG TATAATGAAG GAAGGCGGGG AGGCAGGGAG GCAGGGAGGC AGGGAGGCAG GGAGGCGGGC AGGTGGGGAG GGAGGGACGG AAGGAGGGAG GGAGGGAGGG AGGGAGGGAG GGAGGGATAA AAAAAGAAGA ATGAGGTTGA AACCAGGACT TAGATATTAG AAACAAGCCA TTACAAAATT TATTTCTATG GTTAATTGTG GTTTTCAACT GTAAGTTACT TGGTGTTAAT TTCCTATTAA ACAATTTCAG TAAGTTGCAT CTTTTTATCC CATCTCAGGT CAAATACTTA ACAGACTAAA TGATTTGAAA AAGCAAAAGT TTACTGGCTT GTGTGTGTTA AAATGGAGGT ATGGTGGCTT TGATATTATC TTCTTGTGGT GGAGCTGAAT TCACAAGAGA TCGTTGCTGA GCTCCTACCA GACCCCACCT GGAGGCCCCA GTCACTCAGG AGAGATCAGG GTCTTTCACA ATCAGGTTCT ACAAAAATAA ACATCCCCCC AACCACAGCA GTGCCAGTTT CCATGTCAGA AACTTAGATC CAAATGACTG ACTCGCGTCT CATTATCATG ATGGAAAAGC CCAGGCTTGA GAAAGAAGCC CGCTGCGGAT TTACTCAAGG CGATACTGAC ACAGGGTTTG TGTTTTTCCA ACATGAGTTT TGAGTTCTTA CACGCTGTTT GCTCTTTTTG TGTGTTTTTT CCCTGTTAGG TGTTTTTGGT GGTATAGGCG ATCCTGTTAC CTGCCTTAAG AGTGGAGCCA TATGTCATCC AGTCTTTTGC CCTAGAAGGT ATAAACAAAT TGGCACCTGT GGTCTCCCTG GAACAAAATG CTGCAAAAAG CCATGAGGAG GCCAAGAAGC TGCTGTGGCT GATGCGGATT CAGAAAGGGC TCCCTCATCA GAGACGTGCG ACATGTAAAC CAAATTAAAC TATGGTGTCC AAAGATACGC AATCTTTATC CTAGTAATTG TGGTCATTGG GTGATGTTGG TTTGGGCAGG CCATCTCTAA TATCCTTGAA ACACCTTTTT CTGCTCTCCA GGAAGGGGTC AGGGCTGCCA CAGCGGGGCT TGGAGTGCTT TCCAGGGTCA CAGGCATCTG TATTCTTTGG ATTCCTTGAC CTTCCCCATT TATTCCCGGC ATTTTCCTAA AACGTGTGCT TTGCTCCTCC TGCATCCTCC CCTTGCATGC CCTCACCTAC CCCACATCTT CCCTAAAAAA AGCAAGCCCA ACTCAAAGAC CAGTTCCCTC ATGGAATCAT AGTGGATCTG CCAAGGGAGG GGATGCCCAG TCCTCTGTTC TTCACAAGAC TCCCTTCTTC TGGCTAAGGT TTCTTATGCA ATTAT CTGCAGTGGT AAAAAGATTC TATATCTGCT GTTTGATGAA TGCAGCACCC ACTAGCCACA TAGTGCTCGT GAGCACTTGC AATGCGGCTA GGGTGATTTC AATTAACCTA AAAGAGAACA GCCACAGGGA GCATGTGGCT GCCATATTGG ATGGTGCTGC TTTGAGAACA AAATGAGAGA AATGAAGCCT CTATTTACCT TGGTTGGCGG AACACATTGA AGGGACTCTG TATTGATACC AGGCTTCAAA CTTTGGGAAG TGTACTGGCC AACTTAAACA CATCCACAGG AGAATGAAGA GGTTTGGGAA GGGACCAGAA ACCAGGCATT GAGGACAATG AGAAGAGTTT TTCAAAAGTG GAATTACTGC AAAAAGTGGA AAAATAGCCT TTGGATGGAA GTTACTGATG AGACAATTTC CATCGGTGTG AAAGCCATCT TTCCAACAGA GATCTGCAAC ATGAGAATGT ACTGTCTCCT AGGGTAGCGA TGGCCTCTTG TATTAGTCCG CTCAGGCTAC CAGATTTATC GTTTAAACTG CCCATAAACA GACCAGGCAG TTTAAACAAC AGAAATTTAT TTCCTCGCAG TCCTGGAGGC AGGAAGTCTG CGATCAAGGT GGAAGCAGGG TTGGCTTCTT CTCAGGTGTC TGTCCTTGGC TGGTAGATGA CCGCCGCCTC CCTGGGTCCT CACATGGTCT TTCCTCTGTG TGTGTCTGTC CCAATCTCTT CTTATAAGGA TGCAAGTCTT ATGGATCAGA GCACACCCCA ATGACCGTGT TTAACTTGAA TCACCTCTTT AAAGTTTCTC TCTCCAAATA CAATCACCTC CTGAGGCACT GTTAGGGCTT CGACACAGGA ATTCTTTTCC TAGGGGATTC AGTTCAGTCC AAAACGCCTA CCAGTGGAGA CTTGCAACAT GGCGGCCTGC TGGTCCCTCG CCAGGAATAT CACAGGCGAC TGTTCCCTGT TGCATGGAAT AGAAGGCTAT TCCAGAGTAC TGTCTCTATT TATCAGATCT GGGATACTGG GAGAAGGGCA AAATAAAGTC CAAGTAGAAA AAAAAACTAT GAAAGTTTTA GAGAGTAACC ATAATTTCAG CCCGATGTGA AACGATCCTA GATTTCAGCT GAAATAGTGA TGTGGGAAGT EPI-109 47

GAGGGGGCCG GGATTCAAGG CAGAGGGAAC AGCGTAACTG AAGGCATGGA AGGAGGGAAG TGTAGGCTGT GTTTGAAGAG TGGCAGCTGC TTCCACATTT CTAAAACACA GGATGTGATT TTGGGGTGTG TTGAGACAAG GCAGAAAACT TGTTTGGAAA AATAACTTGA ATTCCCTGCA CATTTAAAAT CTCTCAGCAG AAGAAAACCC CACTCAGAAC CCCACTGTTC ATTCCTTGGC TTGTATTTGG SCACAGCTGG CATAGCCCCA GACTGAGTAA GCTCTTCAGA CACCTCATTT CATGAGTAGC CCCAAAGATC AATCATGGGC CAATTTCTTG GAAGAGAAGA CTCTCCGGTG TTTTGCAGTT ATTTGTTCTG CTTTCGCGAG ATGTTCTCAA ATCGTTGCAG CTACAAGCCA TGAGTCTGAA GTGTTTGTGT TCCCTCCTTA CAGGTGGTAA CTTTCTCACA GGCCTTGGCC ACAGATCTGA TCATTACAAT TGCGTCAGCA GTGGAGGGCA ATGTCTCTAT TCTGCCTGCC CGATCTTTAC CAAAATTCAA GGCACCTGTT ACAGAGGGAA GGCCAAGTGC TGCAAGTGAG CTGAGAGTGA CCAGAAGAAA TGACGCAGAA GTGAAATGAA CTTTTTATAA GCATTCTTTT AATAAAGGAA AATTGCTTTT GAAGTATACC TCCTTTGGGC CAAAATGAAT CTTGTGTCTC AATTGGAAGA GGTAAAGAAG TAGGGGGTTA GGGTGCATGG GTTGGAACGT GAGACAGGTC GAACCACAAA GCCTGCCTGG AAAAGGGGAG TGACGTCCTA GGCTTCAGTG ATGTCACCTC CACTTTGTTT GATCCACAAA CCAACAGGTG ACTGATTTTG GTCAGCTCAG CCTCCAAAGG AGCCAGCCTC TCCCCAGTTC CTGAAATCCT GAGTGTTGCC TGCCAGTCGC CATGAGAACT TCCTACCTTC TGCTGTTTAC TCTCTGCTTA CTTTTGTCTG AGATGGCCTC AGGTGGTAAC TTTCTCACAG GCCTTGGCCA CAGATCTGAT CATTACAATT GCGTCAGCAG TGGAGGGCAA TGTCTCTATT CTGCCTGCCC GATCTTTACC AAAATTCAAG GCACCTGTTA CAGAGGGAAG GCCAAGTGCT GCAAGTGAGC TGGGAGTGAC CAGAAGAAAT GACGCAGAAG TGAAATGAAC TT GAATTCACAT TTCTCACCTT TTGATGTATT AAGAAAGTAT GGAGAAATAT ATCCTCTATC AAATTTTCAT GCCTTCAATA ATTTCTAATT CATCAGTCAG TGTTTTTCCA TCCTTTACTG TGATGATGCC CTTTCTTCCA AACTTTTTCA TTGCATCAGA GATGATGTTA CCAATTTCTT TGTCTCCATT TGCAGAAATT GTAGCAACCT GTGCAATTTC TTCAGGTTTG GTCACAGGTT TAGACTGCTT TTTAAGTTCA GCAATTACAG CATCAACAGC TAACATCACA CCTCTCTTGA TTTCCACTGG ATTAGCACCT TTGCTAACCT TCTGGAAGGC TTATTTGGAA ATAGAGCATA CCAGTACAGC AGCAGTGATA GTGCCATCCC CCAGTCTCTC CATTTGTGTT ATTGGCAACA TCTTGGACAA GTTTAGCTCC AATGCTTTTA TATTTATCCT TTAAGTCAAT TGACTTTGCA TCAGTCACAC CATCTTTTGT TACTTTGGGA CTTCCCCAGC TATGTTCAAT AATTACTGTT CTTCCCTTTG GCCCCATTGT AATGGCTACA GCATCGACAA AAAGTCTACA CTTTGAAGCA TTAAGGCTCA GACATCAGCA CCAAATTTTA CATCTTTACC ATCACTTCAA GTGAGGTGAG GAGCCAGTAG CCTGGACACT GGTCTCATCT GGTGAAAGAC TGTGGGTAAT GGAAGCATTT CTGTGGGGTG GTGGCAGGAC ATGTGCATGG TGAGGCAGGT CATCAGCAGC AAGTGAGAGC TGCCTCTTAC TTTCTAAAGG TGACATAGCA AGTATACAAA AAAAAATAAA ATATTAATTT AGGCAGAGCA CATAAAGGCT TTATTTCATA TTCCATTTCT CTGTATGCTT TCTTCACCAG GAAGAAATAG TTTTAGTGTC AGGAATGAAT GAGTCTGCCC CTCAATTCCA GCCTGCTCAG CACACAAGGA AACAAAGCCC TGACAATCAG AGTGACTCCC TGGTGACTAA GCTCCAGTCC TGGATGCATA TTTGTTTAGC AGTTCTGACA GCATCTGACC CAGCCCTCTC TTTGCATACC CCACCAGAAC CTTCTTTTTT TTTTTTTTTC TTTGAGACTG AGTCTTGCTC TGTCGGAAGC GATTCCCGTG CCTCAGCCTC CCAAATACCT GGAATTATAG GCGTAAGCCA TCATGCCTGG CTAATTTTTG TATTTTTCAT GGAGATGGGG TTTTGCCATG TTGGTCAAAT TGGTCTCACA CTCCTGACCT CATGTGATCC ACCTGCCTCA GCCTCCCAAA GTGCTGGGAT GACAGGTGTA AGCCACCATG CTAGGCTCAG AAATTTCCTT TTATAAAAAT GTCATTAAGG ATCTTGGCTG CACAATATCG TTACCAGCTT CCTTTAAATC CACCTCTGGC CTGCCAGGAA TCAGGGTTCT TCAGAACCTG ACATTTTAAA TGAAGAGGTC AGGCAGGTCA TGAGGAAAGC CTCATTGTCC CCATGTCTCT GTCACTGCTG CACCCCTGAG ACATCACAGA CATGGACACT GGGGCCTGCT TGTTTCTCAA ACTGCCCTTA GATCGAAAGA GGGAGGAACC AGGATGAATG CCACTCATTT TCCCAAGAAA GGCCCTCTCC TGAGTGCCCG GGATGGGGCT CTGTCCATTG CCTGGGGCCG CCAATTGCTA CTCTGGGTTA CGGAAGAAGG ACAGGGTCCT GAGAGACACC AGAGACCTCA CACAGCCCTG AAAACATGGG GCTCCTTCAT AAGTGTTTCC CATCACCAAC AGGGAGACCA CGTGGAGGCC TTGCAGCCCT ACTCGGTGCT TCTCCACCAA ATCCCAAGGG CAGTGACGCT GACGTCTGTG GAAAGCAGAG AAAGCCCTGG CTCCCAAAGC CCTGAAGTCC TGTGGAGCTG ACATTCCCTG AGTGACGGTG TGAATGGAAG GAACTCAAGT GCGGGTGGTA GGCCACCTCC TGGCCCAGGC CTGGGTGAAC TCTGAGGGGA CACATGTAGT CACAATCCCA TCCTCCCATT CTCCTTCTCA GAGGAAGGAA GTGGGCATCC ATCTGCCTCA TCTCTCTCCC GTGGGGAAGA TGGGGAGTTT CAGGGGAACT TTCACATAAA TTTCACCAGC TCAGATCTCC TGTGAGGATG GGGCCCACCA TGCTCCCGGT GCTGCCAGAG GCCCTGAGCC CCTCCAGGGT CCCTGGGTTT GAGCCAGCCC TGTATCATCC CCAGGAGCTG AATGTCCGAA CAATGGATAG AATTAGATGG AAAGAGCTCT CAATTTGGCC TGAGACTGTC CCCAGATACT CAGGAAAAAC AGGACGTCGC ACAGAGTGGG CAGCAGGTGA GTGGCAGGTT ATAGGTCCTG AGTTTGAGTT TGTTCTCACG TGAGACAGAC CCAGCCCCTC ACTCCATTCA CACACTGGGT TTTAAATGGT GCAAGATAGG AGGAATTTTC TGGTCCCAAG AGCAGGAGGA AGGGATTTTC TGGGGTTTCC TGAGTCCAGA TTTGCATAAG ATCTCCTGAG TGTGCATTGT TCTTTGAGGA CCATTCTCTG ACTCACCAGG TAAGTGGCTG AATTCTAACC TCTGTAATGA GCATTGCACC CAATACCAGT TCTGAACTCT ACCTGGTGAC CAGGGACCAG GACCTTTATA AGGTGGAAGG CTTGATGTCC TCCCCAGACT CAGCTCCTGG TGAAGCTCCC AGCCATCAGC CATGAGGGTC TTGTATCTCC TCTTCTCGTT CCTCTTCATA TTCCTGATGC CTCTTCCAGG TGAGATGGGC CAGGGAAATA GGAGGGTTGG CCAAATGGAA GAATGGCGTA GAAGTTCTCT GTCTCCTCTC ATTCCCCTCC ACCTATCTCT CCCTCATCCC TCTCTCTCCT TCCTCTCTCT GTGTGTCCCC TCCATCCTTT TCTCCTGCTT CTCTCTCTTC TTCCCTCTCT

CTC ΠTTTT CTGTCTTTCT TTTTCCTCTC TCCCTAGAGC ATGTCTTTCT TTCTTTCTCT TTCCTTTCTT CTACCCACAC TΠTAGACTG AGTAGACTGA ATGCCCTATT TAATTGAACC AAGCATTGCT TCCTTCAATA GAAAAGGAGT TTGAGAACCC AATGGACAAC TCACTCGTTC TTCTAAGCCA ATATGAAGGA GCCCAGTAGT TTGTAAATAT CATCTCTTCA CTGCTTTCCA TGCTACAACT GCTGAGACTA TGGTTGAAAC CTGTTAGGTG ACTTTTTAAA TAAAAGGCAG AAATTTTGAT TTTATCTAAA GAAAGTAGTA TAGAATGTCA TTTTCTAAAT TTTTATATTT AAAGAGTAGA TACTGCAACC TAGAGAATTC CAGATAATCT TAAGGCCCAG CCTATACTGT GAGAACTACT GCAGCAGACA CTCTGCCCCC AGGACTTTTC TGATCAGAGG CCCTGAGAAC AGTCCCTGCC ACTAGGCCAC TGCAGGTTCA CAGGACAGGG ACAGCCCATT GAAACCAACT TTTAAACCTG GATGCCTAAC CTTCATTTTC TCCTTGATAT TATGAAAATA AAATAAAAAC CATGAAAGGA TAAAAGAGGG AGAGTGGAAG GGAAGGATGG AGAAAGGGAA AAAGAAAATT TGAGAGTAAA TCCTAAAACA ATTAATCTAA TAGATATCAT CTTGTGAAAT CCTCATTTTA CCAATCTTAT TTATGAGTCC TGGGTTTTGT GAGAACAATG GGGTTCTGAG AGGCACCAGA GACCTCATAT TTTCCAAAAC CTAGAACAGT ATAATGAAGG AAGGAGGGAA GGAGGGAGGG AGGGAGGGAA GGAGGGAAGG AGGGAGGGAG GGAGGGAAAC AAAAAGAAGA ATGAGGTTGA AACCAGGACT TAGATATTAG AAACAAGCCA TTACAAAATT TATTTCTATG GTTAATTGTG GTTTTCAACT GTAAGTTACT TGGTGTTAAT TTCCTATTAA ACAATTTCAG TAAGTTGCAT CTTTTTTATC CCATCTCAGA TCAAATACTT AACAGACTAA ATGATTTGAA AAAGCAAAAG TTTACTGGCT TGTGTGTGTT AAAATGGAGG TATGGTGGCT TTGATATTAT CTTCTTGTGG TGGAGCTGAA TTCACAAGAG ATCGTTGCTG AGCTCCTGCC AGACCCCACC TGGAGGCCCC AGTCACTCAG GAGAGATCAG GGTCTTTCAC AATCAGGTTC TACAAAAATA AACATCCCCC AAACCACAGC AGTGCCAGTT TCCATGTCAG AAACTTAGAT CCAAATGACT GACTCGCGTC TCATTATCAT GATGGAAAAG CCCAGGCTTG EPI-109 48

AGAAAGAAGC CCGCTGCGGA TTTACTCAAG GCGATACTGA CACAGGGTTT GTGTTTTTCC AACATGAGTT TTGAGTTCTT ACACGCTGTT TGCTCTTTTT GTGTGTTTTT TCCCTGTTAG GTGTTTTTGG TGGTATAGGC GATCCTGTTA CCTGCCTTAA GAGTGGAGCC ATATGTCATC CAGTCTTTTG CCCTAGAAGG TATAAACAAA TTGGCACCTG TGGTCTCCCT GGAACAAAAT GCTGCAAAAA GCCATGAGGA GGCCAAGAAG CTGCTGTGGC TGATGCGGAT TCAGAAAGGG CTCCCTCATC AGAGACGTGC GACATGTAAA CCAAATTAAA CTATGGTGTC CAAAGATACG CAATCTTTAT CCTAGTAATT GTGGTCATTG GGTGATGTTG GTTTGGGCAG GCCATCTCTA ATATCCTTGA AACACCTTTT TCTGCTCTCC AGGAAGGGGT CAGGGCTGCC ACAGCGGGGC TTGGAGTGC GAATTCCCTG TAAGCCCTGT TACAGGGGCT GCACCCCAGA TACAACCTGA CCTGTGTCCA AGGCGGGCAA CTCAACCCTT AGATATTGAA TGGGTCCCAT GGCACCAATG CTTAAACACC AGCAGCCCTC ACAACCACAG ATCGTGTTTT AAGGATGAGG AGGTAGTTCT CTGGATGCAC AGGCTTCAAT CCAAATGGGC TCATGACGCC GCAGCACACA CCCAGTCTGC AGCCTGAAGA GTTGGAGCAT TGCATTCACA GAAAGCATCC AGACATGATC ATGGGCTCAG GGATACACCT GTTCTCCGAT GTGTACCAGT GAAGGATGGA AACTCCTATG CCTCCCAGAA AGCACCACTC AAGCTTTTGC TGAATGCTTC TCTGAAGGCC CACAAGGCTG AGAGGCTGTG CAACACCAGC AGTAAAGTGA ATGCCCAGAC TCCCACCTCC TTTCTTGGGT GGCCATCTGG AAAGGCCACT CCCACCCTGA TGGCTAATGC CTCAGACCAG TTCTTGGCCC AGATGATCCT AGACAATTGT TTAAGCTTAA ACTGTTCATT GGCCAAGCAA ACAGGTGATA GTACCTCTGG GGAACCACAT GCCGCGTGTA CATCCAGATC TCAGGAGAAC CCAAAAATGT CTGTTCCACA TAGCAACAGA AGCCCAGGTA GCACTCAGTC TCACCTGGGT GTTCTCCAAC ATCCCAGCTC AGCCAAATGG CTTTCATTAG TTTTTATGGT TAGACCCCAG GTCCTCGGGA CACTGCTTTA GAAACACATT CCAAATCCTC CTCTGTGTGC AGGTGGCATT CCTATCCCAA TCTCTTTGCA GGGCGTATAC TGTGATACGC AGCCAGGCTG TCCCAGAGGC CTTAAATATT CCCTTGGTGC AGGTAGTTCA GCTTAGCCAC AGCCAATGCA TCACAGGGTC AACTGTGTTA GGAGCCATTG AGAATCCATA GTTGGTTGCT GCCTGGGCCT GGCCAGGGCT GACCAAGGTA GATGAGAGGT TCCTCTGTGG AGTTCTACTT TAACCTCACC TTCCCACCAA ATTTCTCAAC TGTCCTTGCC ACCACAATTA TTTAATGGAC CCAACAGAAA GTAACCCCGG AAATTAGGAC ACCTCATCCC AAAAGACCTT TAAATAGGGG AAGTCCACTT GTGCACGGCT GCTCCTTGCT ATAGAAGACC TGGGACAGAG GACTGCTGTC TGCCCTCTCT GGTCACCCTG CCTAGCTAGA GGATCTGTAA GTACTACAAA ACTTAAACTT TACACTGAGT TTTCATCATT GAAGCTATGC CTCCAATCTG ACCTCTGACT GTGGGGCCGC CCCAGAGGGA CCCAGCGGGT GAATCCCTGC TAGGAACGTC TGTCCGGACC TCTGGTGACT GCTGGGGACG ATGGCTTCCA GCTAACTTAA TAGAGAAACT CAAGCAGTTT CCTTCTAAAT ACACATGTCA CATGTCCTGG TTGACATGTC CAGTAAGAAG ACTATCACAG GTCTTTGGAA CATTCTTTTG AGAGAAACCT ATTTAGGTCC TTGGTCTGTT TTTCAATCAG GTTGTTTGAT TTTTGCTATT GAGTTGTTGG AATTCCTTAT GTATTCAGAT ATTTGCCCCT TCTGCCATGT AGGTTTTGCA AATATTTTCT CTCATTTTCT GGGTTATCTT TTCACTCGGT TGATTGTTTC CTTTGCTGTG CAGATGCTTT AGCGTTAAAT GAAGCCACAC TTGTCTATTT TCCCTTTTAT TGCCTGTGCC TTTGGTGTCA TAGCCAAGAA ATCATTACCT ACATCAATGT CAAAAGCTTT ATCCTTCTAT ACACTTCTAG TAGTTTATGG TTTCAGTTGT TACATTTAGG TTTTCAATTC ATTCTGAGTT GATGTTCCTA CATGGTGTGA GATAAAGATT TAAATACATA CATATATAAA ATCATGAGGT AGTGTACACT ATAAATATAC AATTGTTAAT TGTTACTCAA GTCTAAGTAG AGGTGGAAAT AATAAACTTT CTTTTTTTTA CTTAAACCAC TCTGTGTCAC TGAGCTGATT TCACCTTTAG CCTGATAAAA TCATTGTCCT CTCCACCCTG ATTCCTACAG GAGACTACTC ACCCCATAAC CTCAAAAACC TCTTCATGAG GATGGTAAGT CACCTGAATC CTGAAGTGAA TTACTCGCTA TTCCATTGGA ACTCATATAG GACACCAGAA TCTAGACCTC CAGAGAACAG CAGGACCCAT CTTCAGAAAA TAAGAAGCAT TTGTTCCCTG AGCCTGTTGA ATCAAAGTGC AATTTCTATT CTTTTTGGAA TGTTAAAAAG TGAATCATAA TATTTAAGCA GGTGAACCCA CGAGTAACAT AGCAGGGTCT TTCTTGTCAT TATTAGCTCC AACCTAGCAC AGACATTAAA GGTACAGATG TATACTAGCA TGAAACTGGG AGAACAGGAG CATTCGAGCA ACCTTGAGAC CAATGGGCCT CTCTTATAAA ATGCACACCT CCTCTCACTG AGATTGAGGA AGGTTTCTTG TCTCCGAGCC TTCTCCCAGT AGAGCTATAA ATCCAGGCTG GCTCCTCCCT CCCCACACAG CTGCTCCTGC TCTCCCTCCT CCAGGTGACC CCAGCCATGA GGACCCTCGC CATCCTTGCT GCCATTCTCC TGGTGGCCCT GCAGGCCCAG GCTGAGCCAC TCCAGGCAAG AGCTGATGAG GTTGCTGCAG CCCCGGAGCA GATTGCAGCG GACATCCCAG AAGTGGTTGT TTCCCTTGCA TGGGACGAAA GCTTGGCTCC AAAGCATCCA GGTGAGAGAG GCAGGCATGC AGAGCTGCTA AGTCTAGAGG GAAGGACGGG AGAGAGGTTC CAGAGTTGGG TCTCAGCAGT CTATGTCACT GAGGTGGCTT CACTTAGAAT CTCTGGGCAT TGATTTTCTC ATCTAGAAAT TGAACAGAGA GCCAAATAAA CCTGAGAAAC TTTATTTCTC CAAAGACTTG ATTCCAAGAA ACATCTGTGA AATTCACTAA GTTTAAGATA TGAAGAGACA GACTAGTTAT TTCTGGATCT AAACAAGTAG ACTTAGTTGT AAAGAGAACA TTTTACTCTA TCTACAGAAG AGCTTTTAAA AACTGCAGCC AAGCCTGAGG GTAAGTTCAG GTGTGTGTGT GATGGGGCAG GAATGCAAAA ATGAGAGCAA AGGAGAATGA GTCTCAAATT CTGTGTGACA AGCACTGCTC TGCGTGTTTA TTCCTATCGA CTGAGGTTGT TCGTGCTACC GGCTGCAATG CAGCCAGCAT CACCTGTCAG CTAGCATGTG ACTTCCCCGA GATTCTTTTT CTTACCCACT GCTAACTCCA TACTCAATTT CTCATGCTCT CCCTGTCCCA GGCTCAAGGA AAAACATGGA CTGCTATTGC AGAATACCAG CGTGCATTGC AGGAGAACGT CGCTATGGAA CCTGCATCTA CCAGGGAAGA CTCTGGGCAT TCTGCTGCTG AGCTTGCAGA AAAAGAAAAA TGAGCTCAAA ATTTGCTTTG AGAGCTACAG GGAATTGCTA TTACTCCTGT ACCTTCTGCT CAATTTCCTT TCCTCATCTC AAATAAATGC CTTGTTACAA GATTTCTGTG TTTCCACCTC TTTAATGTGT GATATGTGTC TGTGTCAAGA CACTTGGGAT ACACGTACCA AAACGCAAAA TCAAATTTTT GAACAATATA CCTACCTTGC TATAGAAGAC CTGGGACAGA GGACTGCTGT CTGCCCTCTC TGGTCACCCT GCCTAGCTAG AGGATCTGTG ACCCCAGCCA TGAGGACCCT CGCCATCCTT GCTGCCATTC TCCTGGTGGC CCTGCAGGCC CAGGCTGAGC CACTCCAGGC AAGAGCTGAT GAGGTTGCTG CAGCCCCGGA GCAGATTGCA GCGGACATCC CAGAAGTGGT TGTTTCCCTT GCATGGGACG AAAGCTTGGC TCCAAAGCAT CCAGGCTCAA GGAAAAACAT GGACTGCTAT TGCAGAATAC CAGCGTGCAT TGCAGGAGAA CGTCGCTATG GAACCTGCAT CTACCAGGGA AGACTCTGGG CATTCTGCTG CTGAGCTTGC AGAAAAAGAA AAATGAGCTC AAAATTTGCT TTGAGAGCTA CAGGGAATTG CTATTACTCC TGTACCTTCT GCTCAATTTC CTTT GATCAAAATT TTTACCTATT ATGCATTTGA TATATAAATA AGTATATAAA TGCACACACA GACACAGCAA TGATGGTGAA CAGTCTTCAT ACAATTATAT GGATGAATCT CATAAAATGC TGAGTTAAAG AAATCAGACC AAAGAACATA TACTGAAAGA TTCTCTCTAT ATACAAAGTT CAAAAATAGG TGGACCAATT CATGGTGGTG TTAGAAATCA GAAGAGAGGC TACCTTTGTG GGGAGGGGAC AGTTTAATGC CCAGAAGCGG TAAATAAGGA ATCCTCTGGG GAGTGGTAAT GATCTGGATG CTGGCTACAG GATGTGTTGG TTGTAAAAAT GCATTTTTTT ATATCTAGCT TTTTCCATGT GTATATTATA CTTCAAAGAA GTTCAGTTAA TAATTTCTCA TGTCACTGTA GAGTAGCTCA GTTAGCCCCA GCAAGCCTCT GGCTTAATCT TGTTTTACCT TAAGCCATCA GTCATTTACA AGTAGGAAAA TTCACAGGGA AAGTTAGAGT ATAAAATCCA GAATGAAGGT TTACTGGGTA AGAGTCTCTC CATTTTCCAA AGCCCGTTTA TTTCTTGATT CCAGTTCTTA AGAAGTCTCA GCATTGTGTC TTTTTCATGT ATCTTACAAG AAGACAGCAT GTGCTTCTAA CACCTGATAC ATTGTATCTA CCAGCACTTG GTAAACAGAA AAGAACCACA TTTTTCTTGT AGGAGAAATT TGGTGCCTAT TTCCTACCAG GCACCAATAA GTGGGACCAA TAGGTGGGAT TAAAGATACA GTAGAAAGTA TTTAAAACTT GCCAGGGGGC AATAGTCTGA AAATAAGTAA ATTGGTGCTA EPI-109 49

TAGAATGGAA GTTACAGGCT TCTTTCTTTT TTCCCACAAG ATCTGCTCCT TGAGCCCCTA GAGACTTTTC TGTCTGTTAC TGTTTCTTCA TTCCTCATCT GCAGAGCCAG CCCTGAGAAG TGCAGACCAA AGCCAGGGAA GGCTCTGCAA AGATGTACAA ATGGAAGTCA CCTTAATAAC CTCTGACTGC TGCGCATAAT ACATTTCACT CAAAAGAGGG GTTAAACAAT GGAACAGAAT ACAGAGGCCA GAAATAATGC TGAACACTGA CAACCATCTG ATCTTTGACA AAATCCACAA AAACAAGCAA TGGAGAAAGG ACTCCCTATT CCATAATGGT GCTGGGATAA CTGTCTAGCT ATATACAGAA GATTGAACCT GGGCCCCTTC CTTACATCAT ATACAAAAAA TAACTCAAGA TGGAGTAAAG ACTTAAATCT AAAACCAAAC ACTATAAAAA CCCTGGAAGA TAGCCTGGGA AATACCATTC TGGACATAGG ACCTGGCAAA GACTTCATGA CAAGACACCA AAAGCAATAG CAACAAAAAC CAAATTGACT AATGAAACTA ATGAAACTCT TTAGTTGTAC AACAGATAGT TTATCTGTAC AACAAAATAA ACTATCAACA GAGTAAACAA CCTACAGAAT GGAAAAATTT TTTGCAAACT ATGCATCTGA CAAAGGTCTA ATATCCAGAA TCTATAAGGA ATTTAAACAA ATTTACAAGC AAAAAAATGA CCTCATTAAA AAGTGGGCAA AGGACATGAA CAGATGCTTT TCAAAATAAG ACATTCACAC ATCCAACAAC CATATGAAAA GATGTTTAAC ATCACTAATC ATTAGAGGAA TACAAATCAA AAGCATAATA AGATACCATC TAATACCAGT AGGAATGACT ACTATTAAAA AGTCAGACAA TAACAGATGC TGGTGAAGGT TGTGGAGAAA AGGGAATGTT TATGCACTGC TAGTGGGAAT GTAAACTAGT TCAGCCATTG TGGAAGAGAG TGTGGTGATT CCTCAAAGAA TGTAAAACCG AACTGCCTTT CAATCCAGCA ATCCCATTAT TGGATATACA CCAAAAGGAA TAGAAATTGT TTTACCGTAA AGGCGCATGC ATGCATATGT TCATTACAGC ACTATTTACG ATAGCAAAGA CATGGAATCG TCTAAATGCC CATCAGTGGT AGACTAGCTA AAAAAAAAAA AATGTGGTAC ATATACATCA CAGAATAGTA TGCAGCCATA AAAATGAACA AGATCATCAT GTCCTTTGCA GCAACATGGA TGTAGTTGGA GGCCATTATC CTAAGCAAAT TAATGCAGGA ACAGAAAGCC AAATACCACA TGTTCTCATT TATAAGTGAC AGCTAAATAT TGAGTACACA TGGACACAAA GAAGGGAACA ATAGACATGG GACCTACTTG AGAATAGAGG GTGGGAGGAG GGTGAGGATC AAAAAGTACC CATAGGACAC TGTGCTTATT ACCTGGGTGA TGAAATAATT TGCACACCAA ACCCCTGTGA CACACAATTT ACCTATATAG AAAACCTGTG CATGTACCCC TGAACCTAAA AGTTAATGGT GGGGGGGTGG GGTTAAGCTA CTTTGTGGTA TAAATCTGAG CATTCATATT AAAATAAAAT ATTTACCTCA TTAGAGTAAT TAACATTTAT TAAGCAAAGA GCCAAGTACC TTACACACAT GATGTTTAAT CTCACAATGA TCTTTAATCT CATAACAACC GTCCATTGTA TGTACATATG TGGAAATTGA GCCTTGGAGA GATTAAATGC ATGGGGCATG CCATTTGACT AGAAACTGGA AGCATCAGGA TTTAAACTCA GTTCTGAATG GTTTTGTAGG CTTTGTTTTT TCCACATTAT AGCATGGCCT GCCATGAAGA ACAGGTCCTT TCTGGTGTTT GTCTTGTTTG GTTTAAGTGA AGCAAATATT TATTTAAATA TTCAAGATAT GCTGTTAAAT TTTTACTCAA AAATTTGAGT ACAGTATGGA TCTTCTGAAG CCAAATAACT CTTATTCAAT GCTTAGTTGA GAAATTTTAT GGAGTAGTTC TCAATTTTTA TGTAGTTCCA CTGCAAAGGT AAGTCTTATG GAAAGATTCA CTGTAATTTT TTTTCCTCAT TTGGACATCA GCTTTTTCTT TTCCTCAGAC CCGCTGAAAG ATAATTTTTA AAATAAAAAC CTTGTTTTTA TATCAAGTGG GGACATTTTT TCCAAATGAA AACCGTGTAT TCATTTTATA TGATAAAATC AATGTTATTA TTTTTAAAAT TTTGATTTAA AAATCATTAA AAATAAATTT TCAGATATTA CCTGAAATTC TACCATCCAG AGATAATAGT GCTTAAAGAT TTGATATATA GACACACACA CATATATACA TATATATCAT CCTAAACTTC TTTGTATAAA TGTATATAAA GTTTTTAATA AAAACTAGGA GATTAATGCC CTTTGAATGA AAATAAATAC AATGTGTATG CTTTAACATC TTGCCTTTAC TTTATAACAT TTATCACAGC AGTCATGAGA TAATGATTTA CATGGTCATT GTTAGTAAGC TAATAGCTAA GTGCATGAAC TCTGGAGCTA GCCTCCCTGG ATTTTAATCC CAGATCTGTC ACTGACCAGC TGAGCAATAC TAGGTAAATT GCTCTTGTTC CTTAGTTTCT TCATCTGTAA AATAGAGATA AAAATAATAT CCACCTCATA GGATTGGTGT GAGCATTAAA TGAGCATACG TATGTAGGCC ACTTAACAAC AATGCCTTCA CATACTGAAC ACAAATATAC GAGCTGTTGT CTTATTGGGC TCATGTTTTT CCTACCACTA AGCCGCATGC ATGCAAGGAC CATGTTGGTT TTGTTCCACA TTGCATCCCC AACCTGGTAT ACAGTGTGCA TTCAATAGTT GTTGACTATT ATTACTAGTG GCATTTAACA AATATCTGTT AAATGAGTGA AGAAATACCC ATTTACTGCA AGTGTGTCTA ATATTGATGG CATAATGGGG GAAACTCAAA CTCTGGAGTC AAACAGGTTT TAAAACCTTA TTCCCTCATC CTCAGTTATT GACGTTTTTT TTTTGGCAGG TGTGTGTGTG GGACAACTTA TTGAACTTTT CTGAATTTCC AGCTTCGCAT ATATAAAATA GAGATAGTGA TTCATTCTTG CAATGTATGG ATTTGAGACA ATTGTGTAAG TTTATCAATA AATAGTAGCT ATTTTTGTAT AAGTATTACA TATAATATCC AGGCCACTGC TTTGCATAAC CCAAAAGGGG CACCATTCAT GCAGAATACA ACATAAATGG TGTCCCTGGA GCAGTGCAGT ATAGGAACCC TGAGGGGACC TACAGTATAC TTTATAGTTC ATAGATTACA AATTATCCCT TTATCAGAGT CTCTCAAGGT TGGATGTATT TGAGGTCCAT AAGAGCAATT TAGGATTAAC AGTAGCTGCA GAAACCATCT GCAGTGATAT TCTCATTTTA AATCCGCGGG AAAGAAGACA GCTATAAACT TGGGACCTGG GTTTAAGCAT TTTAAATGCC AAGTTCACCA TTTTCTAAAA CACAACAAAT ACCCAGTGAG AGAGGGAGAA GGGAAGTAAA TGCCTCTGAA TAAGCAAGTT AATGTCAGTA GTTGTACTGT ATGCATATTG ATGAACAATA GAGGAACCAA TGTCCAATCA GATGAGCAGG ATATTTGGCA ATAACAAGTT GCCTTTGAGG AAAAATGATT TTCTTGGCAA GTTCTTTATC AGCATTACAA AGCTAAAAGC TACGCTTATC ATCACTTATA CTAGCATACC CTGTTGTGCA AATGCTGTCT GTGTTTGCAT CTGCTATTGT TGATGCCTGG TGCATGAATC AGGACTCCAG CCCACAAGTT TTCCCAGAAC TTTCTTATGG CCATCATCTT TAAGTGTCTG GTGAACAGTC ATAGTTTGGT ACACAAAAGG GTCAACCTGG GGGATGGCTA GGGTTTGACT CAGTCGTTAC ATTTCAATAG AGCAGGAAGG GGAAATGGTG GCCTGTAACC TCAGGGAATT TTGCCAGTTG GTCCACCCCA CTCTCTCTCT CCTGCTCTGA GGAAGTGGCA CAGCCTAGAA CAGCACCACA GGTGAGAGAA ATGCAAACCC TAACCAGAGA AGCAGACTCT TTGCCAGTAG TAATAGTTCA GGACCACCAC CAGCTTTTAT TAAAATTTTT AATAACACTC AAGTATTGGC AGAAAGAAAT AATCTTGGGT TAACTATAAC TAGAATATTG ACTCTTCCTC TGTGGAAGAA TCAGCCAATC ACATTTGTTT ACATCAGTTC CCCTGAAGAA GAAAAATACA CTGATGTTGC AGCAAGACAA ATTTAAGCTA GATGTAAATA ACTTCCTTTA GCCTGTAATG CTAGGCTAAT TACATATTGG AACTATTTTT TCAGGGAAGA ATTGTGTAGG GTTTCAGGGA AGAATTCTGA AGAAAATATA GAGCTGAAAT GATCTTGCAG CTCACTGAAA CTGCAGGGTT TAGATCCACA CTGATACTCG TTCTATTATC ACTGTAATGA AGGCTGATGG AATAAGTAAA AATGTTTTGT ATTAGTATGT TTTTACACTT ATTTGCAAGG CATAAATAGG TTAGGTTTTG ATCTTAATTT AATTCTAACA TGTATTGTGC ACAAGCTGTG AGCAGTTTTC AGGAGTTAGG TATCTGGCCA TGACTGATTT TTCAGGAGTT AATCATCTGG TAGAAGGGTC ATACACAATA GGAAGATGTG TGTGACAGGT TGTGATCATT ACTATAATCA CACAGAGAGC TGTAGAATTT TAGGCTGGCA GGGTGGCTCA CGCCTGTAAT CCCAGCACTT TGGGAGGCCA AGGCAGGCGG ATCAAGAGGT CAGGAGATGG AGACCATCCT GGCTAACACG GTGAAACCCC GTCTGTACTA AAAATACAAA AAAAAAAAAA AGCCAGGCGT GGTGGTGGGC GCCTGTAGTC CCAGCTACTT GGGAGGCTGA GGCAGGAGAA TGGCGTGAAC CCGGGAGGTG GAGCTTGCAG TGAGCCGAGA TCGCATCACT GCAATCCAAC CTGGGCGACA GAGGGAGACT CAGTCTCAAA AAAAAAAAAA AAAAAAAGTC ATGTTAGATC CAGAGGGGTA GCAACTGGGG CTGGGCTGTC AGTCAACTCA GTCAACTCAG TCAACTCTGC TCCCCCACAG GAGATGCCAG TGATGCATTT TCATGGCCAA CATTGTCAGT CAGCATCATT GAATTACTCC TGATTATAGA GACACAGCTG CAAACGATTC CCCATTAAAT ATGATGTTTC TTGCAATGTT TGGAAGGTAC TCCTTTTTAG TAAGGGAAAT CCCCTCTTCT GGCTTGCTGA AAGTTTTTTC TTTCCATTTT AAAAATCGTG AATTCCTTTT TGCAATATTG AGGTGGTTAT ATGGTTTCTC TTCTCTAATC TGTTAATATG GTGATTTAAT GGTTAGAAAT EPI-109 50

TTTCTAATGT AAATTCCACT CATATTGCAG AAATAAACCT AAACTGAGCA TGAGGCTATA TTTTTTATTT GCTTCTATAT TTGGTTGCTA TACAGTATTA TGTTTAAGAT TTGTTCACAT ATATTTGTGA ATGGGATTGG ACTATTTTTC CTTCTTGCCG ATTTTTATCT GGTTTTTAAA TTAAGGATAT TTTAGACTTA TGAAATATTT GGCAAACAAT CCTTGGCAAG TAATTTTTTG GGGAATTTGT TTTGGCTATT TTGAGTATTA CCCAATATAT TTTAATTAAG TTATTCTTAA TGTTTTCTTA ATTAAAAAAA TTACCTACTC TAGAGATATT CTTTATGTAC TCCAGATTTT GTCTATTTAT ACCACTTTTC TTTTTTCCTC GATGAGTGTC ATAGATGTTC ATCTATTTTT TTATCTTCTT TGATCTTCTC TTATTCCTTG TTTCTATTAA CTTCTGAAGT TTATTATTTT CTTTTTTCCA CTTCCTTATG GTTTATTCTT TCAATTTTTC TCTAACTTCT TAAGTTGGGT GTTTAATTTT TAGCTTGCTT TGCTTTTTTA GGATAAGCAT TAAAACTACA AATTTTCCTT GTTATTCTTT TGCTGCACCC CAAATTGTTG ATATTTCTAT TGTCTAATTT CTATTCAATT AGAATACTTT AAAGTTTCTT TTTGGTTTTT AAAAACTAAC TTTTTAAATT GACAAATAAA AATTGTGTAT ATTTATTGTG CACAGCATAT GGCTTTGAAA TATATGTACA TTGTGGAATG GCTAAATTTA GCTTATTAAT GTATGCATTA TCTCACATAC TTATCATTTT TTGTGGTGAG AGCTATGTGA CTTTTGAACT TATGAGTTAT TTAAATATTT TTAAATTATT AAGCATATTG GGATTTTAAG TAATTTACCT TTTTATTATT AACTTATAAC AAGTAGAACA GTTAACCTGT ATGATTCTAC ATCATTGAAA TTTATTGACA TTTGCTTCAT AGTCTATTAT ATGGTCTACT TTTGTTCATG TTACATCTGT AGTAGAATTG GCTAATAGTT GAGTAAAGTA CACATATGTC TATGAAATCA AGTGTAATCC AGAGAAAAAG AGAAATTTAC TGAATATATT GTTCTAGGTG CTATTATATG TTGTCATGTT TAATCCTCAC CACAATTGTA TGAGGCAGCC ATAATTAATT CCACTTTACA CATGAGGAGC CTGAGGGTTA AAAAAAAAGC TAGCTCTACT ATTTGTAAAG AATGAAGCAA AGATACAAAT GAAGGCCCAC ATATCCTATA ACTAGATATT TAAGCATTTT AATTCAAGCT TTAAAACTGC TAAATAAAAT GTGCTCCAAT TTCTATATTG ACAGACATAC CTTCCTAATG AGCTGGGGTT CGAATTTAGA AATCTTTGAT GCTTCAGAGT CCACACTGAA ATGTGGAGGC ACATAGTGAG TTGGTCCCCA GCCTTCAGTC CACCCACCTT CTCTTTACTA AATCACCTTT CACATACATG TATGAACACC CCAGCCTCCA AGTCCAAACC CTAAACAAAA TGGGACACCC TTGTGCATAC ACAGAGACAC AGCCCATCCT CAGGAAAACC TGGAAAAGTC CATACAAGTT CTGGAAGCAA GCTTGGGACG GTTTCAGTAG TGTGGTCTAT AAGGGAGGCC TCAGAAGACA GGTTTTCTTA ATTCTGTGAA CTTCTCCCAC AGTAGAAAGG GTGCTGGAGG AGGGTCAGAG TGAGGACTTC TAAAGCATGG GTCCTGAGTA GGGGCCACTC TTGCCCAAGT CTAAGAAGGG TACTAGAATA GCACACTACT ACTAGATACT AGAACCCAGA TACAAGCACA GGTCTTCTGA AATTAATAAT AATAATAACT ATTACCATTA TTATACCAGT AGCTGTCATT TATTTAGTGC TTATTATTTG CCAGTCACTG TTCTAAATTC TTTACATGTA TTATACAACT GCCATATAAC TGCCATATGA GGGATGTACC CTCATTGTCA CCATTTTACC GATGAGAAAA CTGGCATAAA ACGTTTAAGT AACTTGTCCA AGTTACAGAG CTTAGTGAAG CCACAATGTT GCTCAATTTG CTCTCAAACT TCAAAGGGAT GGGAAGGACA CCTAAGTCAT AGAGTCTTTA AGAATCAGAG CTAGAAGGAA TCTTAGATGT TATCTAGTCA GCCTCCTCCC ATTACAGTCC AAGAGAAGAT GGCCCTGAGT TACTTGTAGC TATTTTTGCA TGTGAATTGC AAGTGAATAT ACATTCTACT GAAGATAAAA GATATTTAAA GATATCGCTG GATATAGGAA CAGTGGTTTT AAATCTCTAG GCTTTAACTT TTCTCAGAAC AAGAAATCCT TTTTGGTTTT AATCTATATG CACATCTGTA TTTTTCTCAA TTATCGGGTA GTAAAATATA ACTTTTCTTC TGTAATATTT TTTAACTTTA ATGAGTGTTC CTCATAATAG AAAAGTTTGG AAACCATTGC TATGGGTATA TACTTTCTAA AGGGATAGTA ATTTCTCTAG AATATTCATT TAATGCTCCA GAAGTAATTA GCACAATTGT GCAAGTCTGT GCATCATCAA CTATACATTC TGCCTGTTTA CTCCAAATCC ACATGAAACT GATTATACAG TCAAAGGCGA GCCCAGTGGA GAGGCATTTT TGGAGACTTC CTGGTACATT GAGACAGGGT CGGCCAGTCT GCGTTAGGGT CTTGGTCAAA ACTGCATTTC TGAAACTAAA CTCAGATTGC TTTCTTTTAA GGGGTCAGAA CTGATTCAAA TCTACATTTT TAAAAGCCTT AGATGTGGGG CTTTTCCTAT TCCCAGTCTC CGCTATTGGT CTTTGTGAAT CCACAGGCAA TTTGGCCACA TCCTTGACTC TCTCTTATAT TAAGAATTAA ACAGCTAAGT TCATGCAGAG GAAATATAAC AAAGGAGGGA CTTTCCTACA AGATCTTTGA AAAATGGAAC ATTTGCATAA GTCATATTTA GCCAGAACTG TTGTTTTATA TTTTCCTTTC TGAATACTTT GTTACACCTC CTCCCAGCCA ACCCCCCCCC TCCCTGACCC CAACTAGTCA GAGACCAAAG CCTTCACAAT GGTTTACACT TGAACCTTCC TGGCCCCACC CTCATCATCA CGCCTGAATA ATTACATTCA CTGACTGGTC TCCCCTGCTT CCGTTTATCT CCACTCCTAA ACCCTCTGAC ACCTTAATCT TCCCAGAATA CCATTGTGAT CCTGTTCCAC TCTTGCTCAA GTTTTCCCAG AAACTAGAGT ACAAACTTTA TAAGCTTTAG AGTTGAAAGC CACTCTATCT CTTTTTCATC CCCAGGTCTC TGCCAAGGCA GTATAACCTG TCCAACATCT CTAACTTCAA TACCTTTGTC TTAGATACTA GACTCTCCTC CTGGTTTCTA ATTAAACCTG ATCTAGGATC TAATTTTGCC TCTGAATTCT GTTGCCCTTT GCCAAGTGAT CTCTTCCTCC TCTGAGCCGC AGCATCTCTG AGCTTGCACA CTTAGCATAG CCATAGCACA CACAGCCTTA GCTTGCAGTT CAGGGTGTTT ACCTTCCCTC CCCTTCCAGA TGCTGGATCC CCAGGGATAG GAACTCTGCC CTTATGTGTC CATAGCCCCT GGTAGTATGT CTTGCAGTCG TACATTTTCA GCAAATGTTT AATTGGTTAA TTGAAGACAA CTGTCCCATG CCTTAAGCCT CTCTTTTTGC TAAACATGCC TGTGTCCTTT GTCATTGAAC AACTATTTTG ATCTATTTTC TTCCTGACAT AGGGGTCAGT TCCGAGGATG CTGAAATCAA GAGACATAGC TTATTCTCTC AAAATTGCTT TCAAGAGTGA TTTTGTTGTG AATTGAGAAC TGGCTGCCTA CTTTTGGACT ACCCACTTCA GCAAGAGTGT TTGAAACCAA ATCTATTCTA AGTAATTTTT TATTCCCTTT TCTCTATGGC ATTAGACACA CAGCTCTTTT AAACTACCTT TCGTTATCTA TTAAACAGAC ATTCAGTAAC TCTATAGACA CTGTCTAGCT ATATGAACTT AGACAAACTA ATATCTCTGA GCTTCAGTTT CTTAAAATTT AAAATGAGGA CAATACCATC TATGGCCGGG GATTAAATGC TATGAGGAAT GTAAACCAGA TGTCAGGTAC CATCTCTCTA AAATCCAGAT AAAATGAATT AAAAATACTG GCCGCAAACC CTCTCTAAGA GTTCTCAAAA TTCTCAGAGA GCTTAATTTT CATGCTCACC ATAGCACCGA TTTTCTTCTA AATATTTTGT TTCTACCAAA ATATTTTGTC CCAATTTTGC CTTTTATGGC TATTTCTTCA TATCCACTTT CCCAAACTAA AGAAGCAGCC CCTTCACCTT AAACTCCTCC TTCAAAGCAA CCTAAATACA GGTCTGGGTT TGTATTCCTA GTGGGATGTT ACAGAGGTTA GTGTGATGCA GAGGAGGAGT CATGCTGTTT AAATCCATAC TAGTCCCCAG AGGCCAGGCT GCTTCTGCCA CCCCTACCCC TCCCGCCACA GAGCTCTTCA GCTTCTCACA TTTCTAGTTC TTCTCTCTCT ACTTTCATTA CCTTCTCTCT TTTTTTTTTT CTTCTCATGT GCTCACGGGA GCAGAGAAAA TTAACTCCTC TAAGTTTTCT TAACACAGAG TGCCTTAATT ACATATTACT ATTGTTTGAG TTCCTGCCAA CACTACGTCT GTAGGGTCAC ACCTGCTATA TTAGAGGCTT ATCAAAAAAA GATAGCTTTC TCCTAAAAAG GGATTTGGAT GCCTACTAAG ATAACTGGAT GCCAAGATAA GTTTAACCTA ACAAACTTTA TTATTATTAT TATTATTATT ATTAGAGATA GGTACTTATT CTGTCACCCA GACTGCAGTG CAGGGATGCA ATAATAGCTC ACTGCAGCCT CAAAGTCCTG AGTTCATGCA ATCCTTCTGC TTCAGCTCCC TGAGTAGCTA GGACTACAGG CATATGCTAC TCTGCCCAGC TACTTTTAAA AAAATAATTA GGGATGGGGT CTTGTTGTAT TGCCCAGGCT CGTCTCAAAC TTCTGGTTTC AAGCAATCCT CCTGCCTTTT ACCTCCCTAA TTGTTGGAGT TACAGGCATG AGCCACAGCA CTCAACCAAG ATTTAAAAAC TTTTAAAAGA AATCACATTA CTTACTGTTA TCATCATTAT GGTTACTACC AGTGTTAAAA CAATTGGTAT TGAAAACACC ACTACCAGAT CAAGCTTCAA ACCAAGATGT CAAGTAAATA TTATTGTCAG ACCTCTGAGC CCAAGCCTGC AGGTATACAC CCAGATGGCC TGAAGCAAGT GAAGAATCAC AAAAGAACTG AAAATGGCCG GTTCCTGCCT TAACTGATGA CATTCCACCA TTGTGATTTG TTCCTGCCCC ACCTTGACTG AGGGATTAAC CTTGTGAAAT TCCTTCCCCT GGCTCAGAAG CTCCCCGACT EPI-109 51

GAGTACCTTG TGACCCCCAC CCCTGCCCAC AAGTGAAAAA CCCCCTTTGA CTGTAATTTT CCACTACCCA CCCAAATCCT ATAAAACAGC CTCACCCCTA TCTCCCTTCG CTGACTCTCT TTTCAGACTC AACCTGCCTG CACCTAGGTG ATTCAAAAGC TTTATTGCTC ACACAAAGCC TGTTTGGTGG TCTCTTCACA CAGACCATGT GACATTTGGT GCCGTAACTC AGATCGGGGA ACCTCCCTTG GGAGATCAGT CCCCTGTCAT CCTGCTCTTT GCTCCATGAG AAAGATCCAC CTATGACCTC TGGTCCTCAG ACCAACCAGC CCAAGGAACA TCTCACCAAT TTTAAATTGG GTAAGTGGCC TCTTTTTACT CTCTTCTCCA GCCTCTCTCA CTATCCCTCA ACATCTTTCT CCTTTCAATC TTGGCACCAC GCTTCAATCT CTCCCTTCCC TTAATTTCAG TTCCTTTCTT TTTCTGGTAG AGACAGAGGA AACGTGTTCT ATCTGTGAAC CCAAAACTCC AGCACTGGTC ATGGACTTGG AAAGACAGTC TTCCCTTGAT GTTTAATCAC TGCAGGGATG CCTGCCTGAT TATTCACCCA CATTTCAGAG CTGTCTGATC ACTGCAGGGA CGCCTGCCTG GATCCTTCAC CTTAGTGGCA AGTACCACTT TGCCTGGGTG GCAAGCACCA CCTCTCCTGG GGGGCAAGCA CCACCTCTCC TGGGGGGCAA GTACCCCCCA ACCCCTTCTC TCCATGTCTC CACCCTCTCT TCTCTGGGCT TGCCTCCTTC ACTATGGGCC ACCTTCCACC CTCCATTCCT CCCTTTTCTC CCTTAGCCTG TGTTCTCAAG AACTTAAAAC CTCTTCAACT CACGTCTGAC CTAAAACCTA AATGCCTTAC TTTCTTCTGC AATACCGCTT GACCCCAATA CAAACTCAAC AATGGTTCCA AATAGCCTGA AAACGGCACT TTCAATTTCT CCATCCCACA AGATCTAAAT AATTCTTGTC GTAAAATGGA CAAATGGTCT GAGGTGCCTG ACATCTGGGC ATTCTTTTAC ACGTCGGTCC CTCCCTAGTC TCTGTTCCCA ATGCAACTCA TCCCAAATCC TCCTTCTTTC CCTCCTGCCT GTCCCCTCAG TCCCAACCCC AAGTGTCGCT GAGTCTTTCC AATCTTCCTT TTCTACTGAC CCATCTGACC TCTCCCCTCT TCCCCAGACT GCTCCTCCTC AGGTCGCTCC CCGCCAGGCT GAATCAGGCT CCAATTCTTC CTCAGCGTCC GCTCCTCCAC CCTATAATCC TTCTATCACC TCCCCTCCTC ACACCTGGTC CAGCTTACAG TTTCATTCTG TGACTAGCCC TCCCCCACCT GCCCAACAAT TTCCTCTTAA AGAGGTGGCT GGAGCTAAAG GCATAGTCAA GGTTAATGCT CCTTTTTCTT TATCCAACCT CTCCCATCTC AGTTAGTATT TAGGCTTTTT TTCATCAAAT ATGAATACCT AGCCCACTCC ATGGCTCATT TGGCAGCAAC TCCTAGACAT TTTACAGCCT TGGACCCAGA GGGGCCAGAA GGTCATCTTA TTCTCAATAT GCATTTTATT ACCCAATCCA CTCCCAACAT TAGAAAAAGC TCCAAAAGTT AGACTCCGGC CCTCAAACCC CACAACAGGA CTTAATTAAC CTTGCCTTCA AAGCGTACAA TAATAGAGTA GAGGCAGCCA AGTAGCAACA TATTTCTGAG TTGCAATTCC TTGCCTCCAC TGTGAGAGAA ACCCCAGCCA CATCTCCAGT ACACAAGAAC TTCAAAATGC CTAAGCCACA GTGGTCAAGC ATTCCTACAG GACCTCCTCC ATCAGGATCT TGCTTCAAGT GCCAGAAATC TGGCCACTGG GCCAAGGAAT GCCCTCAGCC TGGGATTCCT CCTAAGCCAT GTTCCATCTG TGTGGGACCC CACTGGAAAT CGGACTGTCC AACTTGCCCA GCACCCACTC CCAGAGCCCC TGGAACTCTG GCCCAAGGCT CTCTGACTGA CTCCTTCCCA GATCTTCTTG GCTTAGTGGC TGAAGACTGA TGCTGCCTGA TCGCCTCAGA AGCCTCCTGG ACCATCACAG ATGCTTTTGG TAACTCTTAC AGTGGAGGGT AAGTCCGTCC CCTTCTTAAT CAATGCAGAG GCTACCCACT CCACATTACC TTCTCTTCAA GGTCCTGTTT CCCTTGTCTT CATAAATGTT GTGGGTATTG ATGGCCAGGC TTCTAAACCC CTTAAAACTC CCCAACTCTG GTGCCGATTT AAACAACATT CTTTTATACA CTTCTTTTTA GTTATCCCCA CCTGCCCAGT TCCCTTATTA GGCTGAGACA TTTTAACCAA ATTATTTGCT TCCCTGACTA TTCCTGGACT ACAGCCACAT CTCATTGCTG CCCTTCTTCC CAACCCAAAA GTGGCAACTC CTTTGCCACT TCCTCTCATA TCCCCCTACC TTAACCCACA GGTATGGGAC ACCTCTACTC CCTCCCTGGC AACAAATCAC ACCCTCATTA CTATCCCATT AAAACCTAAT CACCCTTACC TGGGTCAACG CCAGTATCCC ATCCCACAAC AGGCTTTAAA GGGATTAAAG CCTGTTATCA CTTGCCTGTT ACAACATGTC CTTTTAAAGC CTGTAAACTC TCCTTACAAT TCCCCCATTT TACCTGTCCA AAAACTGGAC ATGCCTTACA GGTTAGTTCA GGATCTGTGC CTTATCAACC AAATTGTCTT GCCTATCCAC GCCATGGTGC CAAACCCATA TACTCTCCTA TCCTCAATAC CTCCCTCCAA AACCCCTCCA TAACCCTTAT TCTGTTCTGG ATCTCAAAAC ATGCTTTCTT TACTATTCAT TTGCACCCTT CATCCCAGCC TCTCTTCACT TTCACTTGGA CTGACCCTGA CACCCATCAG CCTCAGCAAC TTACCTGGGC TGTACTGCCG CAAGGCTTCA TGGACAGCCC CCATTACCTC AGTCAACCCA AATTTCTTCT TCATCCATTA CCTATCCAGG CATAGTTCTT CATGAAAACA CACGTGCTCT CCCTGCTGAT CATGTCCAGC TAATCTCCCC AACCCCAGGA CTGGCAAATT GACTTTACTC ACATGCCCCA AATCAGGACA CTAAAGTACC TCTTGGTCTG GGTAGACACT TTCACTGGAT AGGTAGATGC CTTTCCCACA GGGCCTAAGA AGGCCACCGT GGTCATTTCT TCCCTTCTGT CAGACATAAT TCCTTGGTTT GGCCTTCCCA CCTCTATACA GTCTGATAAT GGACAAGCCT TTACTAGTCA AAGCACGCAA GCAGTTTCTC AGGCTCTTGG TATTCAGTGA AACCTTCATA CCCCTTACCG TCCTCAATCC TTAGGAAAGG TAGAACTGAT TAATGGTCTT TTAAAAACAC ACCTCACCAA GCTCAGCCTC CAACTTAAAA AGGACTGGAC AGTACTTTTA CCACTTGCCA TTCTCAGAAT TCGGGCCTGT CCTCGAAATG CTACAAGGTA CAGCCCATTT AAGATTCTGT ATGGACGCTC CTTTTTATTA GGCCCCAGTC TCATTCCAGA CACCAGCCCA ACTTGAACTG TGCCCCAAAA ACTTGTCATC CCTACAATCT TCTGTCTAGT CATACTCCTA TTCACCATTC TCAACTACTT GTAAATGCCC TGCCCTTTTT TACAGTGCTG ATTTATACTT TTCCTCCAAA CCATCATAAC TGATATCTCC TGGTTTTACC TCAAACCGCC ACCCTTAAGT CTCTCTTAAA GTGGATAGAA GATCTTCAGT GACAAGGTAC ACTCCAATAC TTTCACCCTA ATAAAGCCCT ATTCTTTACT TTTATATTCA CTCTTATTCT TGTTCCCATT CTTATGCCAC TCTCTACCTC TCCCCAGCTA TCTCCACCAC ACTATCAATC TCACTCACTC TCTCCTAGCC ATTTCTAATC CTTCTTTAAC AAACAATTGC TGGCTTTACA ATTTCTCTTT CCTCCAAAAT CACCGAGTCC TCAATTTACT CACTGCTAAA AAAGGGGACT CTGCATATTT TTAAATGAAG AGTGTTGTTT TTACCTAAAT CAATCTGGCC TGGTATATGA CAACATAAAA AAAACTCAAG GATAGAGCCA AAAACCTTGC CAACCAAGCA AGTAATTATG CTGAACCCCC TTGGGCACTC TAATTAGATG TCCTGGGTTC TCCCGATTCT TAATCCTTTA ATACCTGTTT TTCTCCTTCT CTTATGCAGA CCTTGTGTCT TCCATTTAGT TTCTCAATTC ATACAAAACC GTATCCAGGC CATCACCAAT CATTCTATAC GACAAATGTT TTAAGGGAGG AGACCACCCC TCATATTGTC TTATGCCCAA TTTCTGCCTC CAAAGAAAGA AGTAAAAATG AAAAGGCAGA AATGAAATCC ACAGGCAGAC AGCCTGATGC CACACCCTGG GCCTGGTGGT TAAGATCAAC CCCTGACCTA ATCAGTTATG TTATCTATAG ATTACAGACA TTGTATGGAA AAGCACTGTG AAAATCCCTG TCTTGTTCTG TTCCTCTAAT TACCAGTACA CGCAGCCCCT AGTCATGTAC CCCCTGCTTG CTCCCCCTGC TTGCTCAATC AGTCATGACC CTCTCACGCA GACCCCCTTA GAGTTGTAAG CCCTTAAGAG GAAAAGGAAT TGTTCACTCG GAGAGCTCGG TTTTTGAGAC ATGAGTCTTG CCAATGCTCC CAGCTGAATA AAGCCCTTCC TTCTTTAACT CAGTGTCTGA GGGGTTTTGT CTGTGTCTTG TCCTGCTACA GTTTCATCTA ACAACCCCAT AATATCACCC CTTACCACAA AATCTTCCTT CAGCTTAATC TCTCCCACTC TAGGTTCTCA CGCCACCCCT AATCCTGCTC GAAGCAGCCC TGAGAAACAT CGCCCGTTAT CTCTCCACAC CACCCCCAAA AATTTTCACT GCCCCAACAC TTTACCACTA TTTCGTTTTA TTTTTCTTAT TAATATAAGA AGATAGAAAT GTCAGGCCTC TGAGCCCAAG CCTGCACGTA TACATCCACA TGGCCTGAAG CAAGTGAAGA ATCACAAAAG AAGTGAAAAT GGCTGGTTCC TGCCTTAACT GATGATATTC CACCATTGTG ATTTGTTCCT GCGCCACCTT GACTGAGGGA TTAACCTTGT GAAATTCCTT CCCCTGGCTC AGAAGCTCCC CCACTGAGCA CCTTGTGACC CCCACCCCTA CCCACAAGTG AAAAACCCCC TTTGACTGTA ATTTTCCACT ACCCACCCAA ATCCTATAAA ACAGCCCCAC CCCATCTCCC TTTGCTGACT CTATTTTTGG ACTCAGCCCA CCTGCACCCA GGTGATTCAA AAGCTTCATT GCTCACACAA AGCCTGTTTG GTGGTCTCTT CACACCGACA CGCGTGATAA TTATTATATT ACTTTTAACT AAAACCCTTT CAGAGTCTCG CAGGGAAGGC TGTATATATC EPI-109 52

TCATAAAATG TTGGGGCCCA CTGGATCAGA CAAGGCCACA AAGGCCAAAG GGAAGTAAAG ATCTCATTAT TTCTCCTAAT AATTTCCCTG TCCTTTGTCA TAAATGGTGG GTAGGCTGTT ATGGTGATGG CAGATTTTCT TTCCATAAAA TGTCCATAAT AGGACATTTG AACAGAAGGG AAAAATCAAA TTGCTGAAGT TGAAAGAGGG CAATGCAAAG AACTTTGGAG AAAGAACTGT ACAGAGAAGT CAACTGGCAG ATGGGAGGAA GTTTAAGGGG AAAAATATAG ATGTCTAAAG AATACATTTA TTCATTTTCC ACAGTGCAAT TTGGACAAGA AGCCTCTTTC TTGCTTCTTT CTATTCTCAT TAAATCATTA GAGCTCAAGC AATCCTTCTG CCTCAGCTTC CCGACTAGCT AGGACTACAG GTATGTGCTA CTATGCCCAG CTAATTTTTT AAAAATTAGA TTTTAATTTG GTGAACTATT TCTGTAGGAA ACTACAATAA TACAGCCCAG GCACATTGAT CTTGGGTGAA CAAATCAGAA GGAATGAATA ATTCTGTGTT CCTGGGACTC TGACAATTTC ATGAACTTGG TACTCTGAGT AAAGCATAGG AGGAGTTATT TCATAAAATG TGGAGCACAA TCATGTGACA AAGATAATGG GATCCCCATT TCATAAATAA ATCTGAAGTT CAGAGAGAGT AACAACTGGC CAGGGTCACA TCACGGAGAC AGAGGCAGGG TTCCCACTGA TGCCTCTGAC TCCCTGTCCC AGGCCCTTCC TCCTCCCGCA AGCAGAAGTG CAGGGGGCAG AGCTGACCCT GTGCAGTGAA AATCTGAGGG CTGAGTTCCT ATTGGAACAC AAGTGAAAGA CTTCCTGGCT TCTAATCTCA GGATAAGGAC TCAGAGCTCC ATCTGTTCCA GCCTTAGGAT AAGAACCAGA ATCTTACACC ATGAAAGCAT GAAAGGTAAG ATTTGAGTGA GGAAAAAAAA AAAAAAAGTC TGTGTTTCAG ATTCAGTTCA CAAAGCAGTT TCATACTTAA GGTACCATCA CAATAACCCT GTGGGGTAAG CAAGGCAAAT TTCATTCTTG TTTTATGGGC ATAGGAAGTA AGTCTCAGGG AGGTTAAGAC CAAGGTTTCT GGAGAATTTT ATATTATGAA TCTTGATTTA TGGGATTACT ATTATGTAAT TCCTAAGATC ATATAGGAAT CCTAGAGCTT GAATATAGAA CTTTATTTTT AAATCTATAT ACATCATAAT TACAAGGAGT AGTGTCCATT TGGGTTCCTT GGCCCTGATG TGTTAGTGGA ATAAACATTT TTGTCAGGGT TGCCATGTGT GTCTGTGCAC GTGTGCACTG TACACCTCCA GGGGATGTAC CCTAAACCAC ATGAATGTGA TTTGCACATC CAAGATTTAC AGTGTACTAT AGGGAGAATC TTTTGCAACA GCTTTTGCTA TAATACAGAA TCTGAGATGT CTTTGAGAAA GAAAAGTGTA ATCATTACCA AAAAATTATT CTCATAATGT GTGCAAATTT GTATGAAATC TATATTGGCC ATGGGACAAG GAGGTATTTC CAGCTAGCTT CTGAAAGGGC TCTATTCTCT CATAAGAATT CAGCTGTTGA CATTAGGTGA TATCTGCCCA GGTCATCAGA TGCCATAGAG AAAGAGGGTT TGCTGAAACT TATATCAGCA GTGCACTGTA TGCTCTTTCT GATTTATTTG AACATTCATT TATTGAGTGT CAAGTAATGC ACTAGATACT CCAGGGATCT GACACAAACT CTGCCCTGAA GGAGCATGTA ATCTCACTGG GGAGAAAACA AAACATATGA TAATTTCAAA ATAACAAACT AGGCAAACTA GTTAACACTT AAAAAGCAGG CTTTATTCAA ATGCAAAATT GCATGTTACA GGGTAACCTT TCAGTAAGAA GCCAGGAAGA GGAGCTCATC ATGGGTTGGA TTAGTAAAGG ACTAGTTATA AAAGAAGTGG TGGGGTTGAG GGAGGCCTGA GATGAAATTT AAAGAATATG TAGAATCTAG GTAAGTGGAT AAAAGGTCTG GGGGCAGGGG AAAGGAGAGC ATTTCATTGT GAATCAAGGA ATTTCTCCAC CTGTTTTAAC TCTTCCATAT GACATCAAAG AGATGTCACT TGCAGCTAGC ATTTCAGTGA TGTTTTCTTA CTAATAATAT CGTGATAAAA GAAACATTGA CTATAAGAAA TAGGAATGGG TCTCATAAAA GGAAACAGCA AAACCCCCAA ACTAAAAAAC AGCGCAGGCT ATTTCTCTCT TCTCTCCTTT TGCTTGGCAC TCATGAGATG CTAGGTGTGG AAGTCAGCCA ACTGAAAAAG AGAGGTGGCT GAAGAAGGTG GGGAGGCTGA AGCCAGTTAA ATAGGATGGT CCAATTCACA GACGGCGAGG CTACAGTGCA AATAGGACTC TTTCAACTTG AGCAGGACCC CATTACTTCA CTGGAGTTAG AAAGAAAGGA GAGCGTAGAC TTTTTGAACT TTCTATAAGA GTGTACCTCC ACAGTATACA GAAGACGACG TGAAATTTGA TCTGCAAGAA AACTGAGTCC ATATTCACAT ATGTATCAAA TTTGCACTTC ATTTAGAAGT GTCTGTCATC AAGTACAGCA CTGAATTGAA ACTGAAAACA AGAGTCAAGA AAGAGCAAAG TCAGCCATCT TTATATTCCA CATGAATCCT TTCCCTTTAT GGTCTTATTT GTTTCTCCTC AGAAAAGACA AAAAGCTGAG CTGTATAAAC ACCTGTGGGC TGGGGGTTGA GGGATAAATG AGGGGCGAAA TGGAAGCTGA AGGAACTGTT GGTCAGGTAG AAATCTTCCC AGATGCACTG AAGGAAACAC ACTTCATGTT TGACGTAGGA GGTGCCACCA CACAAAACGT TTCATGGAAG GATTTAAAGG ATCTCATGAT TTTTAGTATT CCAAGAATTT TCTTTCACCA AGGGCGATTT AATATGGGTC ATTCATACTG AAAGAAAAAC AAAAGATAAT AAGAGTTTAA AAATTGCAAA ACTTGGAGTG TTAGTAGTAA AGGTAAATAT TCATT AGAGA TGAGAAGAGG AGCAAGGAAA TGCTTTCAGC TGGAAATCTC AGACAAGAGG CCAGGCTTTA GGAACCTCTG AAGATGAACA AATGTAAGCA AACCCTAGTA GCAGCACTTC TCAGATTTTC ATGTGCTTAC CACTCAGAGA TGGTGTTAAA ATGCAGACTC TGATTCAGTA GGTCTGAGTG GAGCCTGAGA TTCTGCACCC CTAACAAGCT CTTTAGTGAT GCTTATGCCA CTGGCGCACA GACCCCACTT GGAGAAATTT TTGTGGTGCA TACGGTCTTT GTCTCCAGAT CTAATGAGTC TGAAGGACAG TGTAGATTGA TTTTTTAAAT TTATGTTTAT TTTAATTTAA TTTAATTTAA TTTATTTATT TATTTATTTT TGAGATGGAG TCTCACTCTG TTGCCCAGTC CGGAGTGCAG TGGCACGGAG GCAGCTCATG CAACCACGGC CTCCTGGGTT CAAGCGATTC TTCCGCCTCA ACTTCCTGAG TAGCTGGGAA TACAGGCACG TGCCAGCACA CCCAGCTAAT TTTTGTATTT TTAGTAGAGA TGGGGTTTCA CCACATTGGC CAAGCTAATC TCAAACTCCT GACCTCATGA TCCACCTGCC ACGGCCTCCG AAAGTGCTGG GATTACAGGC GTGAGCCACC GAGCCCAGCT GTAGATTGAT TTTGAGCAGT GGAAAGTCAA GGAATTAGAA GGCATGCTTA AATGGAAAGT GAAATTGGAG AAAATTTAAA CTCATGAAAT AGTGGTGGTT ATAAACTCGT GATAAATTAT ATCCTGGGAT ATAATTTAAT GAGATGGTAA CACATTTAGT TTAAAGAAAT AAGTGACACT TTTTTTGTGT GACACAACTG TCTTATTCTT GGAAAGGACA AGGAGAGAAT GAAATATGGT ATGTCTTCAC AGCACCTTTC AAAGGGAGAA CCAGATTCTG AGGAGCTGGT CTCATGATGA ACTGTCAGGG TAAACCACAG TTCAGCAGCT GCAAATGTGC TTGCCAAAAT AGAGACAAAA AAATGTTTCT GAAAACAAAA TTTCACATAT GCCCTCCTCT GAGGTTGGCA TCATATCTTC CTGTGTATCT TGGGTGTAGC TTCTATCCTG CCAGAATTTA GACAGTAGAA ACCAAATGAG GTGATAAACA GAGTCATTTT GCAGAAGAGT CAAAATAACC CAGCAAGAAA TGAAACCACA AATGCCCAAG GAGTCATTCA TTCACCATTC AAAAGCTAAT AGAAATGAAC ACAAACTACT ATGAAAATTC ACCCAAGAAC TTAAAAAAAA AAAAAAAGGC TCATGGTGTT TAGTGTGATA GTATTCATTT TACCTTTGAC TTGTTCTAAA AACACACCAT ACTTCTACCC CACCCTTCCT CAGTGCCGTC ACACAATGGT TTCAGTGTGA AAAAAAAAAC CACGTTACTG GAAAAGGAGG GTGCCTGGGA CTTGCCACTC TAAGCTGGTA GTCAAGGGTC TTGAGTTCTA AAAGCATACG CGTTAAGAGC ATGATTCCTG GATCCAAATG AGTATGGATC TCAGCATTGC CATTTATTGT GACCTCAGGC TATTTTATTT CTCTGTGCCT GTTTCTTTAT CAGTAATGAA GATGTTCATA GACCCTTCTC CCACAGACTT AAAGGCATAT TTCATGATTT AAGACATGTA AACCATTCAT AACAGTATAC AACATGGAAT TAATATTTGA TAAAGGTTTA TGATTATTGT AACTAACTCT GTCACTTGCT CAAGGCCTAT AGAAAACTTA CTTAATTAGT TCAACTACAA AAAGAGTTTG AATGTGATAT CCACCAAGAT CATATTCAGA CCTAGAATTC TGTGATTCTT ATGAATTAAT ACAGCCTTGG TCAATAAATG AGAGCTGGGC AAATAATTCT TCTTTGCTAG GCCTTTCTAG ACCATCTGGT GAAGCATTCA AGACTTATGT TATTGGGGCC AGCCTTCCTT TCCAACTTCA ACTCCACAAC TCCTCAATAA GCCATGGGCT CAAGAAAGTT CTGCTCAGTG GCCCCTGAAA AATGCTTTCA TAGTCTCACT ACCATACCAC TGCTTACACA ATTTCCTTCC TACAGACTGC CTTCCTTTCC TGCTTTTCTC CATATACCTA AATCCTATCT ATTCTTCATA AGCAACCTTC TTTATAACAT TTTCTATAAC CACCAAGCCA AATGACCTTT TCCTTCTTAA ATATAGCACC CATTGGCCAT TACCATGCTC TGCCTTGTAT TTTTCTGATT TTTTTCTTTC TATATTCCTG TCTTAACTCC CCAGCTAGGT AATAATTTTC CTGAAATCAG GGACCAGGCT GACTCCTCTT GCTGTCTCAA GAAAGCTTAG CAGTTTCCAA CACAAAAATG TTCAATAAAC AACTATTAAT TGACTGATTA TAAAAAATCA EPI-109 53

GTGAACCATT AAACTTAATA TAGCAATTTG CTTAGCATGG TAATTAGCTT TTTGCTAATA TTCTTCCAGC CAGTCTCTCC TCCTGTGCCT CAAGGACATC TTAAAAAAAA AAAATCTAGT TGATCTGCTT CCATCTAGTG GCAATTAAAA CAGGTGGTTC CGGTAGCCAG AAAACAGCTC TGGGTAGATT GTGCCAGAAA ATACTTTCAC TCAGTAGGTG CGAGTTTGAA AGAAATCTTC ACATCTGTGG GTTTCCTGCC ACAGACATAG GGAGACCAGC CCAGAGAAAG AAGCCTTTCC TCACTAGACT CCATTTGCAC TAGTAAAGAG AAGACAGAGT AATTAAAAAG AATAAAAAGA ACCTCCACTG ATCGTACATC CTCATCCAGT TACCCCTGCC CCACTTCTCC TTCACAGCCA AACATTTTAA AAGAGATGAC TGCTTGTTCT GTCTCTACTT TCTCATCCTC AGTAATGCTC AATGCTTGGC CGTCTGACCT CTGTCTTGAT GTCTGCACTG CAAATAGTCT CCCCACTGAC ACCCTTGTTG CATCCAGGGG ATACTTACTG GTTCTCTTGG CAATGTTTGA AACCGTTCCC CTTTCTTTGT TTCCTTGGCA TTCATTACCC CACACTCTTT CTCCTCTTCC TTCTCCCTGC CTGGCAACAT CTTTTCATTT CTCTTTCCCT TAGGTGACTT ATTAGATAAT GATGTTCCTC TGGCTCCCAT ACTCTCTCCC AGGTCCTCTT CCATTCTTAA AGCACTCACA CCCTCCCTGG ATGATAGTAC CCACTCCTGA GATGGCAGTT ACCTCCTGAA ATGTGAGGGA CCCAAATCCA CTTCTCCTGC CATAGCCTCT GTGCTTTGGA TAGGTCCAAT GAGCCACAGT GAATGATGTG CATACACCCA AAGCTCAGTA CAAAACTGAA CCCATGATCT TTACCTCCAA AACCTCTCAT TCTTTTATGT TCCCTTCTCA GAAGTAAACA GGACTACCAT CCGCCAGTTT CCAGGTGAGA AAGATGATAA TTTGATTCTT CTCTCTCACT TTTAGCCAAT TAACAGACAC ATTCAGTTAA TATCACCTCC TCTTATTTCA TGAACCCATT CTTACTACTA GTTCCCTAGA CAGGCGCCAT CGGTTTTAAT CTAATAACTG CAAATGCCTC CAAAACAAGT CTCTTTGAAT CCAGGCTCAC CTGTCTCCCA CACTTGCCAT ACTGCTCTGC AGGGTGACCT TATAAGATGC CAGAGGTAAG GCTACTCACT GTTTAAACCC CTTTAGTGAT ATCCCAAAAG ACCTCAAGAT AAAGCCCATA TCACATGGCT TATACATTAG TTTATGATCT GGCTTCTGGT GCCTCATTTT TCCCCACTTT TTCCTTTGCA TTCTAAGCAA TGGCCCATAC TAAGTTTGTG ATTGGTAGGA TGGTTGCCCA AACCAGCATC CAATCCCTTC AGAAATCATC TCACTTCATT TCTAGCATTT TAAAGGAAGC TCAGTTGTCC AGCTGGGTAC TGAATATGTC ACCAAAGTCC TCCTTTCATA GTTTATTTTA CTTAAACTCT CCTTCCTAAA ATTCCAGAGC AAGTCACTAA ACCCTAGATA CTGAGAAATA TTTTTCCATC TTCATTTCTG CCAGGTGGGC CATCAACTTT CACATGTCTG CATCTCCTCC CACTGTGCTA TTTCTCCAGT AGAAGAAATT TGAGCTTCAA GACCAAACTG AAAAATACTT GCCTCCTTGG GGAAGCTGTA GGTAGAATTC ATGCTCCCTA TCTTTCCCAC ATTTCTGAAG GACAATGCCT GTTAGAGCAA TTGAATGCAA ATAGTCAATT GAATAAGCAT TTATTCATTT CTCAATAAGT GCTTGTTCAA TTGAATATTT CTTAAATAAT ATATTTAAGA ACAAGAAGAA CACACCACAA TGTTTTTAAC CCTCAGAAAA AATTCTGAGG TAATCAGAAA AATCTCCCTT TACATAAACT GCCCTTTTCT AATAGGGATT ACTTGTTCGT TCATTCATTC ATTCAGCTCC ACTAGCACCA AAAAGCACAG CTCTGAAAGG AAGCTAGTAG ATTTATCACC TTATCTGGTC ATTTGGATGA GGACCCCAGG TAAATAAACT ACTATGGGGT TAATGTGTCT AGCTAGAGCA GGAAGTAACT TAAGGAAGTA GAGAATGAAT CAGCAGATGT GGAAACTCCT CGCCACTAAT AAAACTTACC TTCTCTTGGA TTTCTTGCCT GAAAATAGAA AATAGAGAAA AGGCATTAGC AAAAATTAGA CAATTTAAAG TTTTTCAAGT AAGGGAGAAG GAAGACTCCC ACTCTCAAAA CTGTCTTTTG AAGTATATTA GGTATTTGTT AGGTGGACCC TATCTGTGTC AAAGGAGATT TGAGGAACTG GCTTAATAAA CAGTGGTAGA CACTAATACA GAACAGACAT GTTGATGCAG ATGCCTCCTG AGGTTCCATT CCATTCTCCG TGCTACTCAA GAAGACAGAA 2₅441 TTGCTAAATT GCCTGGTGGC AAGACCCAAT ATGTCCATTC AAGTGTTTAT CCCTTCCCAA TCTGCCATCT CATCCTACCT GCAGATTCTT CCCTTGAGGG ACAGCTGCTA ATACTGTAAA ACTATGTGCC ATTACAGCTC ACAGCATCAT CTCTATGAGA ATCCACAAGA GAATTTCACT TTGGTCTTGT TGGTAGGAAT TGTGCAGCCT CATCTGAGTA ACTAATGTGT TTTTATCTTA CAAACACAAG GAATATCACA TGGTTCTCCT TTGACTGGCT GTAAGGAAAC TCAGAGCTAG ATCTGAGACC CTCTCCTACC AAGTATATAA AACTTTGTGA CATACATTTT TGTGCCATAA CTTCAACCTT GGTTCCAAAT GATTTTTGTA CCCTAAGTTT AAATTTGGCT TTCTTTTTTT TTTTTTTGTA CTCAATAAAA CATCAAGCTC ATTTATTATT GCGAAGAGCG AAACAACAAA GCTTCCACAG CGTGGAAGGG GACCCGAGTG GGTTGCCCAA ATTGGCTTCT TTTTCTTACT TTTTAATTAA TTTTAATTTG CTATACTGAA CACATTTTGT ACTGTTCTCA CATTCTTTTT GAAAAAAGCA GAATATAAAT AAGTAGATAA CTTAAAAAAA ACTCTTTGAG CAGAAAGAAT CATTTGGGAG GCAATATATT TCAGTGGCTG TAAAGTGGCA TTCTAGAATC ATCCTACCCA GGTGAAAGCC CTATTTTGCC ACCTGTAGTG TAGTGTGTAT TTGAACAGCT ACTTTCTTTT CTAAACTACA ATTTCTTCAT CTGTTAAAGA GGCATAATAA TTGTATCATC CTCATTGGGT TGATAAAATA AAATATTTCC AAGTATTTAG TTCAGGTCCT AGCACGTAGA CAGTGTTGCA TTACTGTTTT AATCCTTTAA AGTATTAAAG ACTACTATTT GAAATCTTTT CTTCTAAAAT TCAGCCTGCT GATGACCAAG TGCACTTGAG CAGGGGGAAT CAAATCTGAA TTAATTTCAG ATTCTGGTTA GCTTCACATA AATATTTTTT TTAGGGATGA TGAACCTAAC AGCAATAGAT GAGTAAGAAT CTGTTCCTAC TGAGAGAGTT TCATTTTGAA GAAAAAGGAA CTAAGGGGGC ATGTGTTCAG TTTCATGCCC TGGTCTAACC CTGTGTGTTG GTTCTGGTGG GAAATTCTTC CAACCGAGGA AAAAACCAGT TCACAAATCT GAAGACCAGT GATTTTAGAA GATGTATCTG GACTGGAGTC TAATCTCTGA CTCTGGGTCC TGCTGATATG GTATTTTTGA GATTTGGCCT AAAACATCAT TGCCCTGGTT TCCTTATTTA CCAAACAGGG CCAATGGTAG TGACTAATCA GAAAATGATA ATGCCTGGTG CACAAAATGT GTCTAGATGA GCCCATGCAC AAGGACACAT GTTTCTGGAA CTGTTCCTTA TTCCTTTCCT AAAAGAAAGG AGGGAAAGTC TCCATACTAA GACTACTAGG GCAGGGGACA AAGTGCTAGA GTCAGAAGAT TCATCTGAGG ACAGAAGAAT AGGGGTGAAG GCTCTAGTCA CTTCATTGGC TACCATGCTC TAAATAGTTA CCTGTGCCCT TTTTCTAACT ATTAGAACCC AAAAAGCCTA TAAATTCTCT CTCTCTCTCT CTCTCTCTCT GTGTATATAT ATACATATAC ACACACACAT AGACACACAC ACACACCTAA ACACACACAT AGAGATTTAT GACTTTTTAC TTTTATCCTT GTAAATGCCA TTAACTATAT TTTGTCTTAG ATTTAGCCTG GGAATGTAGC CATTATTTCT ACCATTGCCT CCATAGGAAA AATACTCTTC ATGTTTTAAA GGACCAACCT ACAACTAAAA TCTTTGGAAA GCAGAATCAT TTGTAAGTTG GTGAAAATGG AAGATGTTGT TTTATAAATG AAGACTTTTT TTTTTTTTTT TTTTGAGACA GGGCCTCACT CTGTTGTGGA GTGCAGTGGT GCTGTCATGG CTTACTGCAG CCTTGACCTC CTGGGTTCAA GTGATCCTCC CACCTCAGTC TCCTGGGTAG CTGGGACTAC ATGTGCATGC TACCATGCCT GACTAATTTT TTGTATTTTT GTAGAGATGT GGTTTCGCCA TGTTGCCCAG GCTGGTCTTG AACTCGTGGG CTCAAGTAAT CCTCCTGCCT CAGCCTCCAA AAGTGCTGGG ATTAGAGGTG ACAGCCAAGG TGCCTGGCCC ACAGATGAAG ACTATTTAAT GTTATCTTAA AGATACCCTA AGCTTCCTAC CAAGCCAGTG ATCTTTTGGG GCTTCTGTTT TCTTTGTTGG CATAACTGTA ACTAGCCTAA CTGCCCGTTA TCTGTTTCCT GTTTGCCCCA CACTGATTCC CACAGCAGTT TTCAAGTTAT CGGTTTGAGA TCTTGTACAG AAATGACTCC AAGGTAAAAA ATTTAAAAAC AACCCCTCTA ATTTTTTTAC CCTTGCTTAT AAAACAGCCT TAGCCAGCTA ACCCCTCACT ACATGCAAAT GAGTTTGATT CTATTCTTTT GATTCTACAA ACACTTATTA AAAGATTTTA GAATTCGGAA ATAAATAGCT TCCTTATTAA GGTGACTTAC AGCCCCAAAG TCCTTAAAAT TATTTAGACA ATAGCCACCT TATCCCAGGG GGCAGTGTGT AATAACCCAC CCTGTTCTCT ATCCGTCAGT TCTGCCATCA TCGCCCAAGG TAGGAAGAAA GACAGGACAA CCGGGGTCAA GATTTGAAGT CTCAATGGAA AGAATAATCA GTGGTTGGAG AAAACTGTCA TTCTTCTTTT GCCTTAATGC AGTACTTGAT ACTTATACTT AGTACTGTAT AGTACTTAGT ACTGTATAAT ACTATAAGAT AGTGAGATTC AATCAGCACA GAATTTCTAA TAGCAAGGGC AGAGACATTT TAACTGCTCA GTGCTCTCAG GTTATACATA GCTAATGAAG TTCTTGCATA

TCAACAATCC CCACCCCCCT CACACACTTT GTCTTTCTGG ATTGGTTAGA AAACTTACCT AGCGCCCACT ATTCTCAAAT TTAAATGAAA GATAAGATCA GAGTGGCACG CAATTAGGGA CTGATAAATA ATATTTTTGT AATTGCCAGT GTAAATGGAC AGGGGGCAAC CTTTACATAC CATATTCAGT GAACAGAATA CGTACTAACT AATTTGATGG AAGGAAAATT AAAATGACAA TCAACTGAGC CCACAGAAAG GCAACACAGA GCAGTTGGTT AGCAATTGTT TCGAGATCAT CCCTGAACTT GAAACAGGTA TATCTTTTTT TTTTTTTTTT TTGAGACAGA GTCTCACTCT GTCACCAGGC TGGAGTGCAA TGGTGCGGTC TCAGCTCACT GCAACCTCCG CCTCCCGGGT TCAAGTGATT CTTCTGTCTC AGCCTCCCGA GTAGCTGGGA TTACAGGTGC CCGCCACCAC GCCTGGCTAA TTTTTGTATT TTTAGTAGAG ACAGGGTTTC ACCATGTTGG CCAGGCTGGT CTTGAACTGC TGAGCTCATG ATCCGCCCGC CTCGGCCTCC CAAAGTGCTG GGATTACAGG CATGAGCCAC CACACCTGGC CAAAACAGGT ATATCTTAAA AGCTGCCCAA TGTCCATGAA TGTTACAGCC TTGAATGGTT CTTCCAGGTG AGTTTGGCCA AATGTGGCAC CATACACCCA AGGCCTGCTG CAGGCTAGTG GGTTGCTCAC ACTTTAAAGC TGAGACACAC TCATGCCTTA AGGTAAAGGG AGTGATAATC TGGGCAGCAG ATGTTAACTT CTCAAGGCAG TCCTCCTTCT CTTTTCCTCT CCAGTGACGG ATGGTTGGAA AGCATATATG GTGCATTTGG TTAGAGCTGT GGCCTTGGTG AATAGATACT TGGGAGAATA CATGGGAATT TCTCCCAGGG TTAATGCAAT GCCCATGTGT TGGGAACCAG GTGACTCTTG AAGAGGTCAG GTATTTGGGA GCAGTGCCTT GAAACCTTAG TGGACATTAG ACCCACTTCC TAGTGGAATT GTAGCATTGA AATCCAAGGC ATGTAGGCTC TTAGAGGACA GAGATAGTGT GTCATTTTTT CAGAATTAAT TAAGAGCAGG CCAGGCGTGG TGGCTCACAC CTGTAATCCA AGCCCTTTGG GAGGCCAAGG CAGGCAGATC ACGAGGTCAG GAGATCGAGA CCACTCTGGC TAACACAGTG AAACCCCGTG TCTACTAAAA ATACAAAAAA TTAGCTGGGC ATGGTGGCAC GCTCCTGTAG TCCCAGCTAC TTGGGAGGCT GAGGTGGGAG AATAGCTTGA ACCCAGAAGG CGGAGGTTGC AGTGAGCTGA AATTGCACCA CTGCACTCTA GCCTGGTGAC AGAGTGAGGC TCTGTCTCAA AAAAAAAAAA GTATTAAAGA ATTACATAAG AGCAAAGAAC CATTAGAATA TCTCACTTAG TTGTTATCAG CCTAGCAAGC TGCCTTGAAG GTAATAGACA TTTTTAAAAG TTTATCAGAT GAAAAGCGAA AATCAGCCAA CCTGTTTTAA TGAAGGTGTG TCCTGGGCTG ATTTACATGT CTCCAGGGAC TGATGGCTCT AGAATGTAAA GCTTGGCATC CTGCTTGTGT TGAATCTATC ACATTTAATT TCCTGTGGGT TTCTTTTTTT TTTCTTTTTC ACTTTAAAGT TGTGTTCTTT TCATGTGAAG TTAAACTCAC ATACCTTTTT TTAATCTCCT TGCCAGCCAA ATGATAAATG CCAACCCAGA GAATGCAGTA ACCATGACTG CCACTGGAAT GAAGAGGGGG TTATAATCAC CCTCCTTAAT CATTGAGAAA CTTTTGTCCA ATTCTGAAAG AGAAATCAGT AAGGCACATA GCATGAGACC ACCAGCATTA TTTCCTTAGT CTATCTCATG ATATTTGACT TTTTTCCTCC TTACATCTCC CAGTAGTAGC CCATTTGATG CCATTTGACA GATGAGGAAA CTGGCATGGG AAGGCCCCTG ATGAGTCTAC AGCATAGGCA AAGACTGGAC CAGCCTTGCT AGTCTAATGC CTACAGAATC TCAATGCCCA GATTTGTGGT TCATAGAGTT CCTGAAAATG CACCTAAAAA TGTTGGCAAG AATGGTCATC GTTGTATTTA GCTCCATGGA CTTGTTCAAT GACTGGAACT CTGAAACACA GAGAAGAGCT AAAAGCCTAA TACAACTTCA GGAAAAATAA AAGCCAATGA TCTGAACTGG ATAATTCACC AGTCAAAGGA AATCATTAAT GCTTTTACTT TAAAGCAGTT GTGCAAAAAT AAGCACTTGA TTTTTACATG CCAAGGACCT GCACTAATTT CTTTCCAATG CAGTAGTTAC CACTTCCCTC TACTTCCTTC ACGAATAAGT AAAAGGGCAT GTTTAGAGAT ACTCTTGTAA GTGTAAACTA AGTTCATTTG GGAGCCTCTA TTTGAAAATA CTGGTATAAA AAAAAATCTG TCTCCTGATA CTAACATTTG AAGGAATCTA CTTTTTTACA TATTGGCAGA GGGTCTGATT CTATCCTTAG TTCTTCCCAT TACTTTGATG AACCTTTTCA AGGTGATTTG ATCCCCACAC CCAAATATAT GATTGAGAGA AGGCTCAAGT TCCCAGGAGC TCCAGACAGA AGGTACCTGT TGGCTTGATG AAGATGAGGA GGAAATGAAC ACTAGCTAGG CCTTAAAGGG AAATGTCTCT GATAGGCCTA ATACACAGTC CTCTGCTAAA GGCCTCCCTG CCTCTCTCTG CTCATCCACT CTACTCCCTG GCCCTGGGCA CGCAGCACAC AGAGATCAGC ATTTCTGACA GCTTCTGTAG ATCCTACCAT TTAAAGACTT TTGTCATCCA TGCAGATAGT CTCAGGAGCA GACACAGGTA GCTATTCTTT CACATGCTAG CTTAACATGC ATTTGCTTTA GCACCTATTG CCAGGCACTG TGTCAGGTGG AGGGTATACA AAGATGAACA AGACATGATT CTTCTCATAT ACAGATAGAT TTTGGAGGCA TTAGCTTAGT GATGATTCAG GAGTATCCAT TATTTGGGGA AGTAGGTGGT CATTAGTGAC CTTTTACAGG CATTTCAATG GGCTAACAGA GATGTTAGAT TGTAGTGGAA TAGAAGAATG GGTAAAAAGT AAATCAGTGA GTTCAGATTT TAGGAGTTAA GATGGCAAGA GGTGAGAACA AAAAAAGGAA ATGATTGTCA TTAAAGGAGG AGGAAAGACC AGCCAAAGAT TTTACAGTGA GTTAAGCATA CAAATTTATT TCTAGGCCAC ATATTCTTAG CAAAACAACA TGTAAATGTT TATGTATGTC TTTCCTCATA TCTGCTCATC CATCAGCTCC ATCGTTAAGA TTTCAGTTTT CCAGGACAAA CTTACTCACT TTGACATATT GGACTAGGAT TTGACCAGAT TCCAGATGAT TCACAAATGG TTTTCTTCTT CCCAATTAAC TCAGTTCCTT CTGAGCAGAT GAAGGTACAT GCAGAGGTAA AGCTGAAGCT GGCCAGGGGA TGGCTACAGT TCATGATCCC CAAATCTGGT GCTGATAGAG GCTCACACTG AATCACTTCA ATGAAAAAGA AAAAAAAAAA AAAGACAAAA CAGTATTTCT GAGTAGAGAC CCTCCCTTGA GCAAAGGATT TTTAGCCAAA GCTGCCTGAC TACATTACTT GTGATATTGC TTCCAGGCTT TATTTTCTTG AGAATGATGG TGGGTGGTGA ATGAGAGATG AAGGCAAGGA AGCATTGAAA GCTGTGGGGA GAGGAGTAGC TACTCCAGGC TGCTGCCCTA GCTAAGGTGA CCCTCCCCTT CTGCTGGAAG TACCATGCCA TATGGCCTCT GCATCAAGGG CTCTTATGGG ATATTCTCAG AGAATCTCTG CCGTTTCATC TGTTCTGATA TCTACCCAAG CATTTTGAAA AACATCCCAA TTCACTGAAG CAAGTCCAAC TTCCGTAAAT TCCAGTAGGT GGGTTGACAG TTTTATAATT TCAATAAGGG ATTTTGATAG CACTTCTAAG AATTAAACTA CTTAAACTAA TGCATCAGGA GCATACTTGT AGAAAAGTTA ACCAAAACTT CGTAAGTTCA GATGACATTG GTTTTCTCCC ATATGGAGAT AAGGTTGGCA GTTAAAAATG AAAAAAAAAA AAAAACCTAC CTTATTTCAA ACTTGAAAAG ATCAAGAGAT TGTGTTTTTG TTTTTCAGTT GTTATTCTCC TAAAAGTTTA TGCATGAGGA AAAGTAAAAG TGATTTTAAG AATAAGCCAA ATAAAACAAC CAAGAAAGAC CTCCACTACC CTGGGAAGGA AACTGGTTGG TATTAAGTAG GACACCACAT AAAACAGGTG TTATTGAGAG GAGAAGAACC AAAATGTAAC TGAGGTTCAA CAAGACATTA TTTATGCAAT GGCAATGAGA AAAATAAAAA ACACAGTATA ACCATGCTGT ATTGCTATAA GTCATGTTAC ACACTGGGAG ATGGCTTCAG GGGTATTTGG TTTTTACTTT TTGTTTGGGA GGTTTTTCAA AAAAATTTAG TTAGAATAAG TCCTTTGAGA AACATCACAG TAGGTTAAAC AAAGTTAGGT TAAATTAGGC TCCTAAGTTT GACTTCTCAG CAAACTTCTA CTGAATGTTC TGACTGTAAG CCCAGGATTG CATGACAAAA CCTCTAGTCT GAAGTTACTC ACCTTGACAG GTTGGTTCTG GAGATGACCA GTTTCCAAAT GGTCCACAGG TGGTTTCTTC AATCCCAGTT AAGTTTGTTC CTTCAGAGCA GCTGAAGGCA CACTGTGAGC TGAAGCTGAA GTTTCCCAAA GGGTGAGTAC AGTCCATGGT ACCCAGCTCT GGGGCCTCCA AAGGCTCACA CTGAATCACT TCAATAGGGA AAGAAACAGT ATGGGGAAGA GTTAAGAGGA ACTGACGCCT GGATTTGAAT CCTAGCCCTG CCACTTGATA ACCATGTGCC TTTAAACAAG GTTACTTGAA CCCTCCAACT TCAGTTTCTT CATCTATATA AGAGGAATAA TGAAATTGTG TTATCTTTAT CAAATTGATA TGGAAACTAA ATGTAATTCA ATTAGCATAA GTCAAGGACC TTAGAACAAA GCCTGACTCA TCAGAAATTC TAAGTAAACA TTAGCTAGTC TTCATATTAT TATCTTCAGC ATTATCTGTA GTGAGAATCC TTAAAGCCAA ATAGGTGTAA CTGGGAATGA CCAGCTTAGT CGGGAAATAA CTATCACATC AGAGCCCCTG AGTCTACTAG AGTATTGGGA GCAAGATGTT CAGAGAAAGA GTGGGTCTCC ATAATAAGCC TTCTTTGCAA GGAGAGAATA TAAAAGTCTA GGAAGCATTT TGACCTCAAT TCTGTCTTCT ATTCTAGCTC AGTTCCAGAA TTTTAACTCT TTTGATTTTG ACAACCCTCT CCAGAAACTG TATCTATTTC CCTGTTCTGA

TTGGTGGTAC AATAGGTAAA TTTAAGACTT GGAAATCAAA GTTTTCACAT TTTAGACCCT GCCATGCCAT TTAGTAAACA GTACAACTTT CATGTCTTAT TCCTCATCTG TCAAATTTAA GCCATTATTG CTACCTTGCT CTAGAGACTT CAAGGAAGAA TGGACTCAAG GAATCAGAAG AATTTTTGTA TTTGGAAACT ATATGAGATG AGATTAGGGA GAAACATGGG AACTAAGAGA AAATGTTATC TTTTTTCATT GATTTAAAGA GTATCTATTA TATATCAAGC ATTACTCTGG GGCTTGAAGA GCTTAGATTT CACCCTGTAG GACAAAATGG TAGGTAGAAA TTAATGGGTG GATTGTCATG TATGTGTGAT GTGTTTTAAT TGCTTTTAAT TGATCAGTCT CCCTGTAGTA TGAATAATGT ATTTGAGGGG AGCTAATTTA AAATTGTGGA ACTCATCTAA TAAACTATTG CAAGAATCTA GAAGAAAGAT AATGACGGCA ATGGTAGTAG AGTTGACAAG TGGAAGACAA ATTAGAAAAA CACTAAGTTG TAAAAATTGG TAGAATGTTA CCCTGCATAA ATGTTGGGGG AGTTAAGAGA GTCTCATACC AGGGTGCCCA TGTAAATGGT GATTCCACAT ACTGAGATAA GAAATACGAA GAGAAAAGCT GACTGGGAAC AATTGGTTTT ATAGTCTTTT AAACATCCCA AAGGACATCC TTAGCATATT TGAGTTCAGA GCTGGAGATA GGCTTATCAG TCCAAAGATC ACATAGATTT GTGAGTCCGC AAAAGTCAGT AAGTTTGACC AAAGGATACA TGTAGATTAG AGTCAGAAGA GCAATATACA AAAGACAAAA GCTGAGAAAT TATAGTAGTT TATGGTCCTG GATAAGTGCT CATGAAGGAT CTCAGGAGAA ATGATCACAG GTAGAAAGAA TGAGAAAAGA GTGATATGAG AGAAACCAAG ACAAAGAAAA GTAAAATGTT AAAAATGAGT GAAATAGGCA TACCAATAAT TAAAAATGAG TAAAATAGGC ATACCAATAA CATAAGGGTT AAAAAATAGA GTTCAAAAAT GGGGTGAGGG TAAAGTATTA GGAAGGAGTC ATGGCCCAGG GATCAAGTGA AATGAGTTAG ATCTATAGAT CTATTTCAGT TGGTTGACAT TTAAATGTAT TTTGGTTTTA ATTCTTTATT GTTTACAAAC ATTGCTTTTT TAAAAAATTA AATTGTCCAA TTCAATTCAG GCTCACAAGC AAGTGCCTCA TATATACAGG CATTTTGTGG ATCCCAAAGA TGCAATGATA AATAGGACAC TTACTGATCT CAAGAAGTTT TCAGTACCAG AGGAGACGGA CAAGTGAACA GATGACTTCA ACATAAGTGG GAGAAATGAG GAAGAAATAT GTGGAGCTAT CAGAACTAAG AAAGCTTCCT AGAAGAAACT GTCTTTGAAC AATGTCTTAA AGATGACATG TTTTTTGGCC ATGTGCAAAA TGAGAGAGAA GGCCACCAGC AAAGTCAGTG TGCTACAGAG CACATGTGTT AAGTGTGGAG AACTGCAAGA AGGAAAGGAA CTACTAGAAG GAAAAAGCAA GATACTTTCT GGGTAACTCA GCCTCCTAAT GATAAATGGC ATAGTTTCTT CCAGACCTTA GAGTTCTAAT TAATCTAACA AGCTCATTAG ATCGTGAGCT TCTTGAGAGC GGGAATCTAC CATGCTAATT CCTTATGGTA ACCCTGACAG CTTTTATCCC AACACTGTGC TTCTTGTGGT ACTCAAAAAG ACTTGTTGAG AAGTGAGTCG AAACTTCATG CTGACTTATG AAATCTTTAC GGAAAGGTAA CAATATTGTG AAAGCAGAGC TTTCTGATCA AAACTTCCCA TTTCTCAGAG TGGCTAGTAT CATTTTGTTC CAACCAGCTT CATGATAAGC TATAATGATT CCTGTGACTT TACCTAAGAA GAAGCAAAGA AAGGAAAGAG ACTTACCAAA CTGACACTGG GGCCCATAGT ACCCCACATC ACAGTTGCAG GTGTAATTAT TGATGATTTC TACACATTCT CCATGGCCAC TGCATGACCA GGGCTGGCAA GAAGCTTTAA GGAGGTCAGA AAAAAAATAT TTTAATGTGA TTACATTTTA GTACTCAAAG TCATTTCTTT AGACATAGAT AACCTTTTGT CTGAGATGAT TTAAATAATC AGGAAAGGTT TATTTGTAAA TTCATAGCAT AAAAATCATA TGCTAAAATT TTTACGTATA AAATACACTA AGCATATAGT CATAGGCATT TATTTGCTTT TGGAATGAAA TTACCAATAC TAATATTCTG TAACACTTAT AGGAAACTTA GTGGCATACC TTGAAACTCT TGAAATTACT TGTTTTTAAT GAGTGAGAAG GTTAAATGAT GACCTGACCT CAATCATTTC TGCATGCAAT TATTTCTTGG CAATCCCTTT CTTTATAGAA ATCAAAGATT AAAAAGTCCA AATTTGCTAA AACGGTAGAG TCCAATTTAT AAGAGACCAA ATTAACTATG GTTCATTATT AAAACATCAC TTGGAAAATG CTGGCTGTTT TGGAATTGTA GAAGATTTTA CAGAAATATT CATACACCAA AGATAGTGCA ATTTTTATAT AAAATTATAT AAGGTTAGAC CAAGAAGGAA GCACGCAGCA CCACACTCTC TACTTCACAA TGTGAAAACT GAGGTGATGT GAGCCTAAGT TTCCAACTGG CCCCAGCTGT CAGCTTCTCC TCCCCTGCCT TATTATCAAA GGCACTGATT GTCTAGCTCT TCCTCTGTAC TTCCTACGTA GATCTATCAT TTTGATGTAA CTTGATTTAG GGGTATAGCT TTTGTGCACA GGGACAAATC TTACACACCA AAAATTCTTA GGAGTGACAC GATGCAAGAT TATATAGAGG GCTAGATGTA TTTTAGAATG AACCAGAAGC TGTTCTCATC CCCCCACCTT TCCATGGGGT AAATCTGAGT ATTCTCTTAA CCGTGGCCCT TCCTGAGTCT GAGGCAGCAT AGCCGTCTTG TCACTCCCTA CCTGTGTAAC AGAGGGCTGC CTTTAGTTTG TGGCAGGCGT CATCGTTCCA TTTGCCTGCA TCTTTGTTTC TCTTGATATA GATCTCCACG CAGTCCTCCT TGTTCTTCTT GTTGTTGGGC TCACCATCTC CCCAGTTCTC TGCTTCTTCA GTAAGAGATT TGTTGGTTCC CACCCACGTC CATATTCCTC CTATCTTCCG GATTCCTATC CAGTAGTAAG AACGACTGAA AGGCAGAGTC TTCTCCAGAT ACTCAATTTC CGCCTTGTTT TGTATGGCAA CTAAATCTGT GTAATTGTCT CGGCAGAATC TTCTAGCCCT TTGCCAGTTC ATGGGTT TT CAGAATAATG GTAAGTCCAG CAGTCGGTTC CATGATGTGC CAGGAAATCT GCAAGACATC AGTGTGACCT ATGCAGACTT ACATAATGTT ACAGCTAAAA AGAACCTAGC ACTACTCCAG GCTGAGCTAG ACACTTAGAG ATGAGGAAAC AGAGCCTAAG AGTGTATGTG ACCATCTCAG GATCACAGAA TAGTTGTTTG CAGATTTGAA GTAGAACCTA GACCTTCTGG CTTGAATATA AGATGCTTTT ATCTAAGGTT CTATTTGAAA CAAATTTAGT GGTTTTCTAG GTTTATTTTC TTATTAATTT TTTTCTCAAA ATTATTTCAG GTGAAATTTA ACCAACATAT TTTAGACATT CATATTTCTT TTTCTTTGTA GCTGTTAATG ATTTACAACT AATTACCGTG TAATATCATA TAACTATACA ATTTACGTAT ACTTTTTAAT CCTGGAATCA TTTCTTGAAG GCCAACACAT ATGTACCTAT GGGAGAAGCA TAATAAGGAC AGGAAGAACA GTGACATACT TTTAAGTAAC CTCTTTTACA TAAAAAACAT TTTATTTTAC CATAGGAAGA ACTGCTTCTG GAAAAGCCCA ATATACCACT CAACTCTTAT ATATCTAACT GTATAATTTT TAAAAAGAAC AATTTACAAA GCCAAATGGT ATAGGATTAT GAAATTCATT AGATCATGTT CTATACACAA AGAGACTCAA CTGATGATGT TTAATAAACA TATGGACCCA TCAAATATGA GGGCTTTGAA GATATCTAAT TAAACACATA ATTACACAAT GACTTCATAA TAATATATGG CATTCTAAGC ATGGTATGAT CTACATGAAT CACTATTTAA TACAGTAAAG AAACAGATAT AATTGATGGT AAAGAGCATC ATAAAATAAA CATTTTGAAC AGAGTTTTGA ATGAGCATTC CACTAGAATG CAAGTTCTAA GAGGGAAAAA ACTGTTGTGT CCACTGCTGT ATCCTTAGTG CCTAGCATAA ATTTCACACA TTGTAGGGAC TCAGAAAATA CCTGTTGTAT GAAAAGAGCA CTAAGTTTCT ATGTGACACA GTGCAGACAT GGCATAAGGA ATGTGTGAAC GGGAGAGTTA GCATGTTTGC TTGGCTAGAG CTGAAAATCC AGGCTAGGGA GAAAGAAGAC ATTAGTTTAC TTAGGAAATG AAAAACCAAG TTCAAAGCTA TTGCTGGAGA GTCTTCAAGA ATCAGATATA AAATTTGTCA CAACAATGGG AGAAGGACCA AAAAATGATA AACCCCCGTC CCTTAATAAG CTCGTATTGT AATTGTAGAA ATGACATTAA TGTACACTGA ACTATGAATA AAAAATAGAA AATGAGGTGC TAAATATTTG GTACAGATTG TAAGTACCTT AACAGAGATT TCTTAATTAA CATTATTCCT TTATAATTGA GGGATTTTGT GGGGTTATTG GGATTTGAAC TCTACAGCAT GGGCTATTAT AGGTTAAAAA TAGTGTTCAG GAGTTTCTGG GGAAGAACTA AAGGTAAGAA GAAAAGAGAT GTTTACAGAA GGGATAGAAT TAACAGCTCT GTGAAATAAT TTTCCCTTAG ACTATGTATA ACTAGTGGAT ATTTAAGAAA AATGAATATA AGTAAAATAG ACTTAGCGAT ATATAAATAT CATAACATAC CACAACAGAG CATTGTCCAC CCCCACAACT TGAAGATGTT CCATAAGTCC CTCTGGGTGC TCTGACATTT CCATGGAAAT ATCTGCAAAT GAAATACAAA ATTATATTTA GATGTATACT CTTAAACCAC ACATTTATAG CCTTTGAGGT GGTGCTTACA ACTTTCTTAA TAATCAGAAT AAAACACATA TGTCTACTAA CCCTGTCTGA GGTAACAGGT TTCTCAGACA TAGATGAAAA ATTACTTCAA ATTTACATCA GAACTGATGC ACAGTTTTGT TTTGTTCTAT TTTATTTTTA CGCTTTAGTC TCAAGTTGCT AATCGGTACT GCCCTGAATT TTTTCTATGG TTTGGTAATT TTTATACCTG CTTTTCTGCT GAGCTATTAG ATAAAACTAT TTAATATTTA CTATGTATAT hPl-109 56

TTTTTAAAGT ATTGTTGCTG CTTAATTAAC TATTGATGCT TATATTTAAT GTTATAGCCT CACTCTTGAT CATAATGGGT CAATGCCTCA AATACCTAAA AAAAAAAAAA ATTAGATAGC CAGACACCAG GAAAGAAAAG TATTTCTTTT TTTAATAAAA AGAAATACCT TTTTGAGCAA CTGAAATGAC AAAGTCACAA ATTTCCTGCA CACCTTAAAA TATACTTAAT GTAAATGACG AGTTAATGGG TGCAGCACAC CAACATGGCA CATGTATACA TGTGTGACAA ACCTGTATGT TGTGCACATG TACCCTAGAA CTTAAAGTAT AATTTTAAAA AAATTCTATC TTCCAAAGCA TATCACTTCT CAGGTAGACA CAGTGTTTAT TGCAAAAGAT CTGATTTCAA TAGTATTTCT TCAAGAGTCT CCCCAGAGAC AAAGTCAAGA AGAGGAAATC AGCATATCTG AGAAGAAAGA TTTCAGGATC ACTTTTTTTG AGGGTCTGAG AAAATGTTTA GTTTCTATAT TATTTAAAAC CAGAATTGAA ATGGGGTGAT TCCTATCCTT GCCACCTGCC TCTACAACCC CAAGAGTTTC TATCTGAGCA TCTAAACGTC TTTTAGGCTG AAAGGCTCAC CATGGCTTTG CTTGGTCCTT CTCTAGTTCT TCTGCAGCCC ATTGAGCCTC TTGACTTAGC ACAAGGGTCT CAGGTCCTTG CCCAAAGGGA GTGTGCTGTG CTGCAGGTAG ACTGCACTGA ATGTCAACAG AAAGCCTTGC TTTCTTTCAT TTCTCTAACC CAGTCTCACA TCCTCCTCCT CCTCCCCTTT TCCCTCCCCT TCCTCCTGCA CTTCTCTTTC CTCTTTCCCC ACCCCTTTCC TAGACTGGCC TCTATTGCCT CCCACTGAGA CAAAAATGAA CTGCTGATCA GAAAGTAATG TGACTAGATT CTCTCTTCCT TCCCTCCTTT CTATCCTTCC TTCCATTCTC CTATGCATCT TTCCTTACCC TCCTCCTCCT TCACTCATTG TTGTTGCTGT TCTTCTTCCT CTTCTTTTTC CTCCTGCTCC TCTTCTTCTA CTTGTTCTTG TTCTTGTTTT TGTTTGGTTC TTGTTCTCCT CTTCCTCCTT CTCTCTCTCC TCCTCCTCCT TCTTTTCCAC CACCCTCCCC TATCTTTTTC ATAAATGCTA AACTAACTCT TGGCTACCTG TGGTAAATGG CCCTTGGAAA TTGCAAATAC TACAAATCAA AACTGCATTT CAGACATATT TATGATGTTT GCAAAACTTC AGTAGAGCTA AGCAGTGGAC TTGACTCGTT TCGGTTCCTT CACCTCCGTC TTTCCTTGCT CACCACCTAG TGGACGTCCT TGTTAGTGGC ACTTCCTGAA GTTAACCCCT GAAGAGAGCC CATGCTCTCT AGCTTTTCAC CGTGTAGGTT TGGGAGCCTA CAAGTACCTT TAATATTCTT GGACTATAAA ATGAGATGGT TTTATAAGAC TGCATGTGAA ATTAGGACCC ATATGATGAA GGACAATAAA AAGGAAGACC CACTGATGTG AGTCAATGAG TCAAATGCAA ATCAGATTTG CATTTTTAGG AAAATAATAA TAACAACAAC AAAAACTCTG AAGCTCAGCG CCCCATATTT ATTATATTGT TTAATCTTTA TAACAGCTCT CTGCTATAGA TATGATTATT ATCCCCATTC TAAAGAGTCT CAAAGAGGTT AAGAAACAAA TTCAAAAACT AGCGAAAGAC AAGAAATAAC TAAGATCAGA GCAGAACCAT AGGAGGTAGA GACACGAAAA AGCCTTCAAA AAATCAATAA ATCCAGGAGC TGCATTTTGA AAAGATTAAC AAAATAGATG GACCACTAGC TAGACTAATA AGAAAGAAGA ATCAATAGAC ACAATAAAAA ATGGTAAAGG GGATATTACC ACTGATCCCG TAGAAATACA AACTACCATC AGAGATTACT ATAAACATCT TTACACAAAT AAACTAGAAA ATCTAGAAGA AATGGATAAA TTCCTGGACA CATACACCCT CCCAAGACTA AACCAGGAAG AAGTCAAATC CCTGAATAGA CTAATAACAA GTTCTGAAAT TAAGGCAGCA ATTAATAGCC TACCAACTAA AAAAAGCCCA GGACCAGATG GATTCACAGC CAAATTCTAC CAGAGGTACA AAGAGGTGCT GGTACCATTC CTTCTGAAAC TATTCCAGAG AATAGAAAAA GAGGAACTCC TCCCTCACTC ATTTTATGAG GCCAGCATCA TCCTGATACT AAAACCTGGC AGAGACACAA CAAAAAAAGA AAATTTCAGG CCAATATCCC TGATGAACAT CATTGCGAAA ATACTCAATA AAATACGGCA AACTGAATCC AGCAGCACAT CAAAAAGCTT ATCAACCACA ATCAAGTTGG CTTCATCCCT GGAATGCAAG GCTGGTTCAA CATACACAAA TCAATAAACA GAATCCATTA CGTAAACAGA ACCAATCACA AAAACCACGT GATTATCTCA ATAGATGCAG AAAAGGCCTT GGATAAAATT CAACACCCCT TCATGCTAAA AACTCTCAAT AAACTAGGTA TTGATGGAAC GTATCTCAAA ATAATAAGAG CTATTTATGA CAAACCCACA GCCAATAGCA TACTGAATGG GCAAAAACTG AAAGCGTTCC CTTTAAAAAC TGGCACAAGA CAAGTATGCC TCTCTCACCA CTCCTGTTCA ACATAGTATT GGAAGTTCTG GCCAGGGCAA TCAGGCAAGA GAAAGAAATA AAGTGTATTC AAATAGAAGA GAGGAAGTCA AATTGTGTCT GTTTGCAGAT GACATGATTG TATATTTAGA AAATCCCATT GTCTCAGCCC AAAATCTCCT TAAACTGATC AGCAACTTCA GCAAAGTCTC AGGTTACAAA ATCAATGTGA AAAAATCACA AGAATTCCTA TACAGCAATA ATAGACAAAC AGAGAGCCAA ATCATGAGTG AACTCCCATT CACGATTGCT ACAAAGAGAA TAAAATACCT AGGAATCCAA CTTACAAGGA ATGTGAAGGA CCTATTCAAG GAGAACTACA AACCACTGCT CAAGGAAATA AGAGAGGACA CAAATGAATG GAAAAACATT CCATGCTCAT GGGTAGGAAG AATCAATATC ATGAAAATGA CCATACTGCC CAAGGTAATT TATAGATTCA GTGCTATCCC CATCAAGCTA CTACTGACTT TTTTCACAGA ATTAGAAAAA AACTACTTTA AATTTCATAT GGAACCAAAA AAGAGCTTGT ATAGCCAAGA CAATCCTAAG CAAAAAGAAC AAAGCTGGAG GCATCATGCT ACCTGACTTC AAACTATACT ACAAGGCTAT AGTAACCAAA ACAGCATGGT GCTGGTACAA AAACAGATAT ATGGACCAAC GGAACAGAAC AGAGGCATCA GAAATAACAC CACACATCTA CAACCATCTG ATCTTTGACA AAGCTGACAA AAAGAAGCAA TTGGGAAAGG ATTCCCCATT TAATAAATGA TGTTGGGAAA ACTGGCTAGC CATATGCAGA AAACTGAAAC TGGATCCCTT CCTTACACCT TATATAAAAA TTAACTCAAG ATGGATTAAA GACTTAAATG GAAGACCTAA AACCATAAAA ATTCTAGGAG AAAACCTAGG CAATACCATT CAGGACGTAG GTATGGGCAA AGACTTCATG ACTAAAACAC CAAAAGCAAC AGCAACAAAA GCCAAAATTG ACAAATGGGA TCTAATTAAA CTAAAGAGCT TCTGCACAGT AGAAAAAAAA AAACTATCAT CAAAGTGAAC AGGAAACCTA CAGAATGGGA GAAAATTTTT GCAATCTATT CACCTGACAA AGGGCTAATA TCCAAAATCT ACAAGAAACT TAAACAAATT TACAAGAAAA AACAAACAAC ACCATCAAAA AGTGAGTGAA GGATATGAAC AGATGCTTCT CAAAAGAAGA AGTTTATGCA GTCAACAAAC ATATGAAAAA AAGCTCATCA TCACTGGTCA TTAGAGAAAT GCAAATCAAA ACCACAATGA GATGCCATCT CATGCCAGTT AGAATGGCGA TTATTAAAAA GTCAGGAAAC AACAGATGCT GGAGAGGATG TGGAGAAATA AGAATGCTTT TTACAGTGTT GGTGGAAGTG TAAATTAGTT CAATCATTGT GGAAGACAAT GTGGCGATTT CTCAAGGATC TATAACTAGA AAAACCATTT GACCCAGCAA TCCCATTACT GGGTATATAC CCAAAGGATT ATAAATCATT CTACGATAAA GACACATGCA CACTTATGTT TATTGAGGCA CTATTCACAA CAGCAAAGAG TTGGAACCAA CCCAAATGCC CACCAATGAT AAACTGGATA AAGATGATGT GGCACATATA CATCATGGAA TACTATACAG CCATAAAAAA GGATGAGTTC ATGTCCTTTG CAGGGACATG GATGAAGCTG GAAACCGTCA TTCTCAGCAA ACTAACACTG GAACAGAAAA CCAAACATTA CCCATTCTCA CTCATAAGTG GGAGTTGAAC AATGAGAACA CATGGACACA GGGAGGGGAA CATCACACAC TGGGGCATGT CAGGGGATGT GGGGCTAGGG GAGGAACAGC ATTAGGAGAA ATACCTAATG TAGATGACAG GTTGATGAAT GCAGCAAACC ACCATGGCAC ATGTATACCT ATGTAACAAA CCTGCACGTT CTGCTCATGT ATCCCAGAAA TTAAAGTATA ATTTAAAAAA AGTTTAAAAA AAGAAAGTTG CCTTAGTCAC ATAACTAGTA AGAGACATGG TTGGGAATTT GAACAGAGGC CAATCAGTTC CAAATCCATG CTCTTGATCA TTAAGCTGAA CTTATGGCAG GAACTTGGAA GACATGGTAA AATGGGGAAA AACGTGGAGC CAGGGAGACT TGTGAAAGTG CCAGTGCTCC CACTATACCC TGAAAGAAGT ATCTAGACTT ACTTTTTTCT AAGTCCTCTC CTCTAATTCT CTCAATCTCT CTCTCTCTTT CTCTAAGAGA TGGGAATGCT GCTCTGTCAC TCAGGCTAGA GTGCAGTGGT GCGATCATAG CTCATTGCAC TCAAGGAATC CTAGGGTCTA GTGCCCCTTC TCCCTCAGCC TCCCATGTAG CTAAGACTAC AGGCACATGC CCCAACCCTC GACTAATTTT TTTATTTTTT ATTTTTGTAG AGACAGGATC TCACTATGTT GCTCAGGCTG TAATTCTGTC TTGAAGCTTG TCCAATCAGG CTTTCAGCCA CACCAATTCC CTGAGACTGC TCTCACCAAG GTCCTACACT TCACTAACAC AAACAGCCTA TTCTCCATCC TCATCTTACT TCACCAGGGA GCTCCTGGTT TTCCTCCTAC TTCACTGGCT ATTTCTTCTG TATCATGTGT TGATTCTCCC TCATCTCCCC AACCTCCAAA CCCTTGGAGT ACTCCAGAGA TCACCGCTTT GCTCTTCTGT GTCTAACCTC bHl-109 57

ACTAACTTGG TGGTCCAATT CACACTCTTG ACTTTGAATA CCATTTAAAT GCGAACGAAT TCTAAATTCT GTACAACCAG AACCATTCTC CTGTAGCCAA ATGCCTACTC AACATCTCCA TCCCCAAACA AATTTAGTTG TTCAATAAGC CTCTCATATT TTACATATCC CAAACTGAAC TTCTGAATTT CTCCTCCAAT CTGTAGGGCT CTTCCCACAG CCTTTCCATC TCAGTGGATT ATAACTCCAT CCTTCCAGTT ACTCAGACCA AAACTTTTGG AGTTAACTGA GACACCTCTC TTTTTTTTCA CAAGTCATAT CCAATGTGTC AACAAATTTT GGTAGTGGAA ATATTGCGGG ATTTTTTAAG AAATCAGAGA GACCGATGGG GTTCAGGAGG ATATTTATTA TTTAGGTGCA CTGGCCAAGT CAGATTAACA TCCAAAGGAC TGAGCCCTGA ACAAAGAGTT AAGTTACCTT TTAAGCATTT TGTGGGGTGG GAGAGAGGGG TATCTGTGCA GGGGGAAGCA TACTACAGAA GTGAGAAATA AAGACAGTTA TTCAATTAAT TGAGACATGC ATTACATCAT TTCTTACTTT TCAAGAAGAA ACATGTTTTG CGACTTGAGT TTATCTGTCT AGTGACCTTG CAGCTGCACA GCTAGAGAAA CAGGGTCTTC ACAATGCCTG GGAAAGGAGG AGAGGTAAGT CTCACTAGCC ACAGAAAAAC AGGCAGTTAA TTTTTAAAGG GCTCCAGCTC TTTCTCTTTC TCAGGGGGAG TTGGGTTTTG TTACATACAA CTGAGTTTCC GCTTACACAT TATTTAATTT CTTTTAATTC CTGTTCCAAA AGAAGCCAGA TACAAAAGGT TACATGTTGT CTGATTCCAT TTATATGAAA CATATAGAAG AGGTAAATCC ATAGAGACAG AAAGTAGATT AGAGGTTCCC AGGGGCTGAG GAAGAAATGG GGACTAACTG CTTATAGGGT ACAGAGTTTT CTTCTGATAA AAATATTTTG GAACTAGATA GACATTTTGT TAGGCCATTC TTGCATTGTT ATAAAGAATT ACCTGAGACT TGGTAATTTA TAAAGAAAAG ATGTTTAATT GGCTTACACT TCTGCAAGCT TTACAGGAAG CATGGTGCCG ATATCTGCTC AGCTTCTGGT AAGGCCTCAG GAAGCTTACA ATCATGGCAG AAGGTGAAAG GGGAGCAGGC ATATCACATA GCAAAAGCAG GAGCAAGAGA GGGATGTGGG GAGGTGACAG TCACTTTTAA ACAGCCAGAT CTTGTGAGAA CTCATTCACT ATCATGAAGA CAGTACCAAG AGGATGGTAC TAAATCATTC ATGAGAAACC CCACCCTCAT GATCAAATCA CCTCCCACCA GGCCCCACCT CCAACACTGG GGATTACAAT TTGACATGAG ATTTGAGTGA GAACACGGAT CCAAACCATA TCAGAGATGG TGGTTATACA ATGCGATAAA CGTCACTGGA TTGTACACTT TAAGATGGTT GTTTTATGTT GTGTGAACTT CACCTCAATA AAAAAAAATA TTTAATGTAC ATTCAGCCAA AAGAAGATTT GGAATAGGAA AGGTCATGGA GATATATTAA CAGCCATTTG ATGGGTGGTA AGGAAAAGAG TGGTTATTAG ACTGTTTTGT GGCCCTCAAA AGGTAGAACT AGATCGAGTT GGTGAGCATT ATAAAACCAT CACAAAACCC TGGAGAGAGG ACCCAGTGCT GAAGAACCGT TTGCCTGCCA TGAGACATGA GGGAAGTACC AGTGAATGCC ATTGAAAGCA GCATCCCTGG GTCCAAGGGA TGGTCAAAGG ACCACTACCC AACCCTTCCC TAGCCTACGC CTCCATTACA GATGACCGCA AGATTTATTT GCTCATTGCT GCCAACCAAG GCTGCACTCA CTGCAGTTGC TATCAGTTTA TCATGGGTAA AAGGAATGTG CAGTAGAGAA CTAACTAACT GCCCACCTAC CTCCACAATC CTATCAGGAC AAATCACCAT GGCTCACATT TCCTTACATT TGGCATGTAA GCCCCTCTTA CTGTCTGTCA TCTATCTCCT ACACAGTTCA CCTAAACTGT TCTCTCCTGA CCCAACCTTG ATTTTCATCC CAAATGCTTC CTTGCCATCT CTGGGATTCC TGTCTTCACC ATCACCAAAC TCCCCTCAAT CTTCCAGTTT CCTGTTCAAA CTTTTCTCCT ACCTCCTTGC TTTGTCATTA GCCCGACTGC CTCCCTAGGA CATCACTTCC CCTGCAGATC TCTCAAGATG ACAATATTTA TTCTCCACAC AGCACATACT TCAGGGTTGG AAGGCAGGGG CAATCTTCTC CTTTATAATG AGTGCCTCTT ATATATGTTT ATTCATCTGC CCTCTTGTAA AACACACACA CACACACACA CAAAGAAGAA ATAAAATAAC TCTGCTTCTT TGAAGCTTGT GACACTGAGA TAAACCATCT CACTGTCCTC ATTGTAGTGA CCTCTCAACT CCTCATGCAA GATTGGCTTT GGCACCTAGT TCCTGATCTT CCTTTCCCTG TAAGCACTTC TCATAGTCTT ACGGGACTTC ACCATCCATG GCACAACCAA TACCACAGCC CAGATCCTCA GCTCTCCAAT GACATTTTCC TCCACTAGAC TTGAGCTACC TCCTTCCCTA GGCACAGCCT CAACCTCGAC AACACCTAAG ACTGTACCGT CTCTAAAGTC ACATGTTCAA ACACTTCACT CTTTAACCAC TGTCTCCTAT TCTTGCAAGT GTATTGCTCA AGTATCTCAT TGCAATGCTT TTTACTTCTA CCTCATTGAA CCTCCAGGCC ATTAAACATT TCCTTATTTC TAACCATCAG GTTTCTCCTT ACTTGTTTGT TTGTTTATTT GTTTCTTTTT TTTTTTTTTT TTTGAGACAG GGTCTCACTC TGTTGCCCAG GCTGGAGTGC AGTGGTATGA TCTCGGCTCA CTGCAGCCTC CATCTCCCTG GTTCAAGTGA TTCTCATGTC TCAGCCTCCC GAGTAGCTGG GACTACAGGT GCATGCCACT ACGCCTGGCT AAGATTTTGT ATTTTTATTA GAGAAGGGGT TTTGCCATGT TGGCCAAGCT GGTCTCGAAC TCCTAACCTC AGGTGATCCA CCTGCCTCAG CCTCCCAAAG TGCTGAGATT ATAGGCATGA GCCACTATGC CCCACCTGGT TTCTCCTTAT TTATTTCAAG TCTATGCTGC ACTATTAAAA CTGCCTTGAC AAAAATTATA ATAGTGAGAA AATTATGACA GTGAAAGAGA TCTGAAATAA TCAACCCCCA TCTTGCCTTT ACCTTCCAGA CTGCCCTTAA TAATTCCTGA GCTTGGGCCA AGCTATCTTT GGCAGAAATT TAGTTTATAG TTTAAATGAT AATAGCCCTT CTCCAAAACT AAACTGCCTT TGTAAAACTA ATAAAAGACC ACCAATGAAA GGTTAGGAGG ATGAGAGGAG CCTGAATTCT GCTAAGGTGT AGATGTAAAC AATTACCAAC TGTTATTCCG GAGGTCACAA GATTTGCAAC ATCGCCAATT ACTCCTGCAG ATAACAGCAC TATCATAGAA TCTGATTGGC CTTTTGAGAT GTCTTTTCAG ATTCTTACAT TTCAACTGGT GGCTCTACCT GGACCCATCA ACAAGTCCTG TGGCTCCACC CAGAAGCAGA CTTAACATGC ACAAGGACCA TTTTCCACAC CGCTATGATT GCATCCCAAC CAATCAGCAG CAACCATTCC TCTGCCTGCC AAATTATCCT TGAAAAATCT TAGCCTTAGA ATTTTGGGGG AGGCTGATTT CAGTAATAAC AAAACCCCGG TCTCCCATTT GGCTGGCTCT GCATGAATTA AATTCTTTCT CTATTGCAGT TCCCATCTTG ATAAATCACC TTTATCTGGG CAGCAAACAA AAGGAACCCA TTGGACAGTT ACACTGTTGG CAGATATATC TTGCTTCCAA AATTGGATTT TTGTTTAATG AATTTATTCT GTTTTCTTGA TATTTACAAC TGTGAATGTT GTGTCTGAAT TCTCTTTATT TCTTGTTGAA AAGAACTATA TTGCTACAGC CAGTACATAC AGATGGATAG CTAATTACTC AACACGGGGG GATGTGACCA TCACCGCACT GTGCAAATGA ATGTTACCCA TTGTCCACTT TTCCCAAACT ACATAGTGTT ATATGGTATA TGACCCAATC AACGGTGGCA AAGCTCCAGA AATACCACAT AGACATCAGG GACACTTTAA ACTAATCAGC CTATAGTCCT TTTTCAGTAA TTTCCAAACC TGGTTGTGCA TCCAAATCAC TTGGTAACAT TAAAAAAACA AAAAAATATA CACGCAACAT TCGCTCCCAA TCCTACTGAA TCAGAATATT TTGGGTTGGT TCAGGAACAT TCAGGAGTTT TTCAGGGTCC AAGGTTTATA TAATTTGAGG TCTCTCTTTG AGAAAAGGAA CGTAAAAGCG TCTTGCTTTT ATAGATCTTA CAAAGATGTA TTACCATGTA AACACATTCC TAGGACCCAG GCCCTTGTAA TTTAAAGGTT TATCTAAGTA ATGGGCCCTG AAGCTTAATT TTCATTATCT TCAGGGCAAA TTACCTGTGG GTTAGGGTTT AGGAATATAT CTCTCTGTGT ATGTGTGTGC ACATTAGCAT GTACGCTTGT GTGGATTTTT TTTTTTTTTT TTTTTTTTTC TGAGACAGAG TCTCGCTCTG TCGCCAGGCT GGAGTGCAGT GGCGTGATCT CTGCTCACTG CAAACTCCGC CTCCCAGGCT CAAGCGATTC TTCTGCCTCA GCCTCTTGAG TAGCTGGGAC TATAGGCACG CACCACTATG CCCAGCTAAT TTTTGTATTT TTAGTAGAGT TGGGGTTTCG CCATGTTGGC CAGGATGGTC TTGATCTCTT GACCTCGTGA TCCACCCGCC TCCACCTCCC AAAGTGCTGG GATTACAGGC GTGAGTCACC ATGCCCAGCA CTTGTGTGGA TGTTTTAAGC TCCCAGGTGA GTGAATACAA AACTAGATCT TTCCCTTCTG TAGCATCTGT ACTGTTTACT CTATGCATCT CAATATTTTT TCTTTTAGTA TCTTTCCTTT TTCTCTCTTA TTACTTCCTC TTGTGCTATT TTTACACCTC CTTTTTTAAA AAATTTTTTC CCTTTTATTT CTATTGACCT TTAGCCCTCA CAATGATTCC TACAAGCCCC ATTTCTGTAA ATGGGGATTG AAATAATTGC TGGACTTTTG AGAGATAGAT ATATTAAATT GCAAACTGGC AGTAGTGGGG GCAGTTGATA CATAACTAGG TTTTAAAGTC TAGCCTTCTG AGACCACTCA TTCCATTTGT GAAAAGTGAT TCTACTTCTT ATTATGAGCC AAAATATGCA TTCATTCACC CATGCATTGA TTTATTCATT CAATAAATAT TTGTTGGATG TCCACTCTGT ATCAGGAATG TGCTAGGTTC TGGGAATACA EPI-109 58

GCAATGAACA AGGTAATTTT TCCCTACCCC TAAGGAACTT AGAGTTTAGT GGGGAAGACA GACATTAAAC AAACAATTGT GCAAGTAATA ATCTATAATT ATTTATTACA ATTAAAGGAA GGAAGAGACA TATGGATTAT GAGGGCATTA AAGAGGAGAC CTAGTGTAAG TAGCCAGTTC TCGTGAAGGG ACATGTATTA GTTGGAGTTC TCCAGAGAAA CAGAACCAAT GGTGTGTGTG TGTGTGTGTG CGTGTGTGCG TGTGTGTGTT GGGGTGTGGG GGTGTGGTAT TTTTTATAGA AATTGTCTCA CACAATTATG GAAGCTGAGA AGTCCCATGG CCTGCTGTCT ACGAGCTGAG AACCAGGAAA GCCAGTGGAA TACTTCAAAG TCCAAAGGCC CTGGAACCAA GAGTGCCAGT GTTGGAAGGC AGGAGAAGAT GGGTGTCCCA GCTTAAAAAG ACAGTGAATT CACTCTTTTT GCTCTACATA GGGCCTCAAT GGGTTGGATC ATGGCCACCC ACATTGGTGA AGGCAATCCT CTTAGTCTAC CAATTAAATA CTAATCTCTT TGGAAATACT CTCACAGACA CACTGAGAAA TAATGTTTTA TCAGGGTGAT AGAAATCTTC TGGAGTTAAA CAATGGTGAT AGCTGTACAA TCACATACAT TTTTAAAGGG TGCGTTTTAT GGAAAGTGAG TTTTATCTAA ATAAAATTTC TAAGAAAGAG ACTTAACACA GAGATAAACA TAAGCACATT TATTGTCAAC CTTTATAGTG TTATGTCAAA TAGGTCTGAC ATAAGCTTAA ATAAATATAT ACTTTAAAAA TTATAAAATA TTTTAAGTTA TAATTTAAAA TTCTCAATAA AACTCAAACA CAAACCACAC TGGTATTTCA CACAGCTAAT TTCTAATGCA GTTTACATAA ATATTTACAA CACTTAAACA ATTTCAAAGA AAATAACACT GTATTCCATA CATAGCCTGA TCACAGTAGT TGTTCTCTCT TATTTCCCAG AGTTTTTCTG CCCCTTTAAA AGAACCTCTG CTGTTCTGAT CCTTATCACA TCTCTGTTTT GACTGTTGGC TTTGTTGTTG CCAGTGTTCA GCCAGAACTT CTCTGAAACT TTTTTTTCAA CACATGCTAA GTTAATGGAA GTGTAGGAGA GTTTTGATTC TCACACTCCT CAAGGCTAGA GCAGCTTTGG CAATTACTGA CTGAGAATTT TTCATTGCCA GTGATCAACT GAAAACTGGA GATTCCTTTG GAATTGTTAA ATCTGCTTAT AAATAAACAT AAATGCTTGC TCACACAGGC ATTCCTCTCT TCCAGAGCAC CCTAACATAC AGAAGAAAAC AAATAGGGAA TAACTATTAG ACATCTTCAT TCGTTAAAAA TCTACCAGAT GACTCTTTTA CATGGTGAGT TTCTATTGTG AATTTAAAAT CTTCCATAAT ATACAAGAAT TATGTTTACA TATCATATCT GACAAACATC TTTGTAGGAA TGCAAAGCAC ATCCATCTTT CTGTATTCTT TTCCAACAAA GACATTCATA AAATTATACC TTTGTGTGTT TGCATTTATG CTTTTATTAG TTCAAAACGT TTGGCCTCAT GGAAGTTTTT CATCGTGGAA ACCACATATT TCTGAAAAAA TATCTGACAA TATACAAACC TTCCATTCAG TTTTTACTCT CCAATTCTAC CATGTTTTCA AAAAACAACT GTAGTAAAAA CACTCAGAAC TTTATTCTGG TTAACATCAT GCCTTGCTAG GGGACAATAG TTTCCCTTTT TGAAATAAAT TTAAAACAGA TGTAACATAA TTTGTTAATA AACAATGAGG GGGTAATCTA GAATAAGTAA CTTTTACCAT ATCATAGTTG ACAGCATTTA CAAGTTTTTT AAGTCCCTAC CACACTTGTA TTGAATGAAG AAGTATGGAA GATTATAATA TATTCAATGC AAGTAAAAAT ATCACAATCC TTAAGAACTC TTTAAGAAGC ACTGAATCCC ATAGGGATGA AAGTGATTAA ATTGTGCATA GTAACCCTCG CACAGAGCAT TCAGTAGGAT TTGCACCATT AACAACCCTC CATGCATTTG CCTGTGGGCA TTCAACATCT GTCATTTTTT TAAGTTATAA TATTTTTAGT CATTTTTTTC CTCTAAACTC TGGATAATTA TTATTCATTC TTATGACAGC AACTGTGTAA TCAGCTGTCG AAACACTGTG AAGGGCAAAA GAAAGAAAGC CACAAAATAT TGTGTTTCTG TGCCAAGATT TTACAGCGAG CAAGGGAGAG TTAGAAAAGG AATTCTGAGA TTTCAGAGTC TTGGTCTCTT CACCTTTGCT TGGAAGAAAA TATCCTTTCC CTTCATTAGC CAACACTTTC TTGATCCTGA GAGTAGGAAA GGGAACACTG AGTCTTTTCA GTTGAAGGCC GTCCTTGCCT GCTGGACTTT GATCTATTGA AGTGGTGATG GGTGTTGCGG TTTCAGCCAT AAAGGCATCT GGCATAGTAG GCAAGAAGGG CCAGAGACCC GAGGAGAGTT ATCTGTCTCT GTTAACTTCA GTGTATCCCT CTAGTTCCCC AGATGCACCT GTTTCTGTAA ATATAAACAT GCATGTCATC AGAACACTTA ATATTCTGCA TACTGATCAT GACAACAAAA TGTACCTTCT AACACAGACA CTCTCACTAG GATAGACCAT GTAGGAACAT CGAATTCTAT TCAGTTAGGA CAGTGATGAT GTCTACATAT TATACCTCTG TCAAAACCTA CAGAATATAC AACACAGCAC AGAGTGAATT CTAATGTAGC CTGTGGACAT TAATGAATAA TAATGTATCA ATATTGGCCC ATCAGTTGTA ACACTAATAT AAGATGTTAA TAACAGGGGG AATTGAAGGG GTGGTGGGGA GATATGTTGG AACTCTTTGT GCTTTCTGCT CAATTTTTCT GTAAACTTAA AACCGCACAC ACAAAAAAAG TTATTTTAAT TTTTTAAAAA GTATTCAGAG GGACTTGACC TTTCCAAATT CTCTCAAAGC AGGTCGGAGT AGTTAAGAAC ACAAATTTTA GAACCAGACT GCCAGAGTTT GAATCCTGGC TACACCACTT ACTAGCTTTG AGATTTCAGA CAATTTACTT AACTTCTCTG TCTCATTTTC TTCATCTGTG TGATAAGAAA TAAAGTAACA GGCCAGGCCC AGTGGCTCAC GCCTGTAATC CCAGCACTTT GAGAGGCCAA GGCGGGTGGA TCAGGAGTTC AAGATCAGCC TGGCCAACAT GACGAAAAAA TACAAAATCT CTACTAAAAA TACAAAAATT AGCTGGGTGT GGTGGCAGGC ACCTGTAATC CCAGCTACTC AGGAGGCTGA GGCAGGAGAA TTGCTTGAAC GCAGGAGGTG GAGGTTGCAG TGAGCCAAGA TCATGCCACT GCACTCCAGT CTAGGCAACA GAATGAGACT CCATCTCAAA ATTAAAAAAA AAAAAAGTAA AAAGAAAAGA TAAGAAATAT AGTACCAGCC CCTATCTCAG AGTTCCTAGC TTAGAAAAAT TCCCAGAATA TAATAAGTGC AATGTAAGGG TCAGCTATCT TCATTATTAT TATCTATCAT AAATGAAATT ACACAATAAA GCTAGATCCG TTTCTTTCCT CTCCTTCTAC AAAAAATAAA GCAACTTTCC AGAACAATAC CCAGGTGATG ATTTCTCCCC TGCTCCCTCC CTAAGATATT GGCAAGTTTG GAGGGTTCAA GGAGAAACAG AGCATGTAGA GAAGATACCT CTCTCATAAC CATTTGTGAT TTACAAGTCT TACCTGATTC TTTTGAACTT AAAGGATGTA AGAAGGCTTT TGGTAGCTTC CATCTGATTC AAGGCTTTGG CAGCTGCTGT GGAATACATG AGAACACTAG GTAAAGCACT GTCTTCCAAC ATGAAGAGAG AAAAATATGT GGAATGTTCA ATGGCATGCT TTGTATAAGA ATGCAACTTA CCTGGCAGGA ACAAATTTCT TTGCTGCAAA AGAAAAGACA AACAACCATT AATTCAGACT AAATGACTTT TAAGGATATA TTAAATCCAG ATACAATATG ACTTAATTCA TCAAGTGTTG CAAACTCGAT GCTTCAGGGC CTCTGTAATA ATCAGAGCAC AAGCATGGCT CTGTGGCATC TAGGGTAAAA TGCAAAGTGC ACAGCCATCC AAAGGGCATA GCAGCTTCCT AATGCCAGCA AATAGCTACG GGGTCATCTT GCCCAATTCA GCTCCCAATT TTTCATGAGA AGTCCAAAGT CTTAATTTAA ATGTGAGATT TCCTATTTTG TAAACGTCAG AACTTAACTC AAAAATGTTT TAAGTACTCT TAAACATGTA AGCCAAACAA ACCATGAGTG TAGTCAGATG TGCTTCCATA TTCCTTATGA GAGACTCTCA AATTTAAGCC TGTACTCCAA ATAAATCTCC TTAGGAAGAA TTTTATCCAT TTTCCTTAGA GTGCTCATCA TGGCAGTTCC ATTGCACAAT TCCGGGAGGC ATCATATAAT TCAACATGAA TAGCACCCCC TGGAGTTGTA CAATATTAGG CACGACTAAC ATTTTTATTT CCTGAAACAC TTCCCACACT GAGTTGTACT ACTAACTCTT TTCTTAATAC TTCTGCTTAA TTATACTGCA TTTTATCCAG ATTCTAATTA TTGTTTAAAT CAGTAAGCAA GACCATGACT TATCAATGAG AAAGAAATGT ATTTTCAAAA ACATTTTTGA AGTACATTCA TAAACTTCCT CACCTTTCCG TAAGCATTTC CGAAGCCAGA GGAGAAATGG TGCTAATGTC AGGAGGGAGA GTCCAGCAGC AGAAAGTCCA GCTACCAAGG GAATGTTGGA CTCAGTGGGA GCTAAGGAAG TAAGAGACGA AGAAAGGTCA TGAGGAAGAA TTGATGTTAA AGTCTCTCCG TCCTGTCCCT TTGGCCTTTT TTCTGTACAT TCATTACTAG GAGCAGAAGA GCTATCTAGT TTAATACAAG AAGCAGAGAT GTGGCATTAC AGGCCTTTGA GATCTGCTCC AAGCCACCTT TGAAGCTATT TCCACCATTG GCAGGCAGAA CTCTAACTTG CCAAGCTCGT TCACAATACC ACACCACACC TTGGTTAATA AACACTGCAC TTGCTTGCTC TCTTGCTCTC ACTCCCTCTT GTTTTCCATT TCCCCTTTCT CCTCTCCTCT CTCTGTCTCC TTTTTCCAGT TGTCAGAATT CTACCCTTTC CATCAACATG CAACTTCTGT TTTTTCTCTA TCCCCATACA ACTTAATATT CACAACTTGT CAACCTGGGC GAACTTTCTG GTTTGGATAT AATGAATAGT TGATTACTGT AACAAGATAG CTCCCCCTTT TTCTTTTTAA TCACCAGACA ACCACCATCA ATCAATGCAT CACCTTCACA GGTAGGTAGC AGGCCAGACC AGTGTCCTGT GGCTCCACAT GTCCGAGCTG CAGAGCCATT bPI-109 59

GAGCGTCCAT CCTTCAGGAC AGGCGAACTT GCACACAGTG CCAAACACGG GCTCCCCACT GCAGCTCATG TTσATCTTTC CCGGAACTGC CAGGCTTGAA CATTTTACCA CTGCAAATGT TAGGTACACA GGCAGAGTTT CAGAAAAATC TACTGGAAAA CTTCCAAAAC TTGCTTAAAA GTCAACAATG AATGTAAAGT GTAAGCGCTA CTTAGTTTTC AGCATGTAGG AAATTAGGAC CAAACCCCTT TGGGGCAATC TAGGTTCAGA AACTTTATGA AGTATTTGAC CTGTACCCTA AAAAAGTCTG CACTCAATTC TACCTTGGCA GGAAGGAACC TCTTCTGTCC ATTGTCCCTG AGATGTGCAC TCAAGTTGAG TTGATCCATG TAATTCAAAT CCCTCCTCAC AGCTGAAGGC ACAAGAGGAC TTGTAGGTGA ATTCTCCAAT AGGGGAATGA GCACACCTCA CCAAACCCTT CGGGGGCTGG TGGACAGCAT CGCATCTCAC AGCTGGAACA CACGAGAGAG CACTTTAGAA GTTTGTTTGC ATCTCCAGCA ATACGTTTCC CAAGGTAACC AAGTTCCCAA GCTCTTCAAT AGTTCTTTTT ATCTTAAAAT AAAATAAAAA CAAAGACTGT ACCTTCACAT GTGGGCTTCT CGTTGTCCCA CTCCCCTGTG GGGCCACATT GGAGCCTTTT GGATCCCTTC AACACAAAAC CCTGCTCACA GGAGAACTCA CAGCTGGACC CATAACGGAA ACTGCCAGAA GCACTAGGAA GACAATTCAT GTAGCCTCGC TCGGGGTTGG ACAAGGCTGT GCACTGGAAA GCTGAGACAT CAAAATGATG GTCAGAAAAT ATTGCAGTGG AACTAGAGAG TACTTGGCGT TTGTTGAGTG AACCCAGTTC ATTCAAGCAA CACTTGGAGA ACTGAAGATT CTTTATAATT CCCTGGACAA ATGGGAAGAT GGCTGTGTTT TCTTTGAATT TCAGCCCCCT CACTGATCAT GGCACTAATT AAAAGACTAA TTAATCAGAA CATTAGTTCC TGAGCACTGT TCTTCTAACA CACAAAATAA ATTATGGTCC AAGGAAAGAT TTCACGCAGT CTGAGGACAA CATATGGGTC ATGGATGTTT ATAGATGGTG CCAAAAAGAA AGAAAAGAAA GCACCCCTAT AAAATTTGTC TGTTTTGCAG TTTGGTTTTT GTGTTATGTT TTGCTACTGG AAATCATTCT GTGCTGGCTT TGGCTAGGAC AAGGCCAGTG CCTGATAGTA AAAACTGCTT GTTTTCAATA TCCTTGCTCT CACTTTAAAG TGAATTAAAA TTTACTGCTT ATATATGCAT CAATACTATC TCTGTAGCTG ACACCATGCT TGAAACAGTC TCATCACTGC TAATTATGAG CCATTTCAGA AGACAGGTGT GATGAGAGTT TTACATTCAA ATCATGTTCT CATTATTCTG CTTTCCGAAT TTTCTAATAT GATTCCTTTA GATTAAGAAT TCTGTCTATT CCATGCTAAT GTCTACAAAG TTTTATCAGC ACATCACAGT TAAAAAAAAA CAGCAAAGAA TTCATTCTTA ACACATATGA TCCTTTCCCT GGCCAAACAT TAGTTCTTTT AAATGAATCT CAAAGATACG AGGGTTGCTC ATCAAATCTG ATTTCTATAG TTAAAGTGGG TATTGGTTTT TTTTTTCACT GTCCAAGTTT GAAGATGGTT GTTCTTTAAG AAAGTATAAA TCGAAGGATC TCAAGCTTAC CTTCACAAAC TGGGATTTGC TGTGTCCACT GCCCTTGAGT GGTGCATTCA ACCTGGGCTG GTCCCTGCAA CATGAAGCCT TCCTCACAGG TGAAGTTGCA GGATGATTTG AAGGTGAACT CTCCAGCAGG GGAATGGCTG CACCTCACAG AGCCATTCTG AGGCTGGCGG ACGGCCCTGC ATGTCACAGC TGTAACAAAT ATACGCATTG ATATTAGCAC GGCCTAGAAT TAGCTTGCCC ATTTCCAGTA TGGGTTGAGA GAAAGAATGT TCACAGTAAG TCTCCATGTG GAACAACTCT ACCTTTACAC GTTGGCTTCT CGTTGTCCCA ATTCCCAGAT GAGGTACACT GAAGGCTCTG GGCTCCCATT AGTTCAAATC CTTCTTCACA GTCAAATGTA CAGGTTGTGT TCCATGGGAA GCTTCCAGGG TTTTGGAAAC ATTCCACGAA CCCATTGGCT GGATTTGTCA CAGCATCACA CTCAACCACT GAGGATTTTA AAGAGCACCA TGAATTTTAC AGAAGAATGA TCTTTTCACT TCCTATTGAG CTGGGTGCCT AACAGAGTGA GGAAGCTGCC TTCAAAGGGT AGATCCCAAA GTCCTATGTC AATTCTTAGG GACATGCACA GCCAGAATAA AAGCTTTTAT TCTTTTTCAT GGATATTCTA TCTTTTCTGA TTTCCACTTT GCCTATGCTG AGTGGTCTCT AATCTATGTT ATCATTTACG TGAGGTAAAA ATTTAAAAAA AATAGATTCC AGATTAGGAG TTATGACTAG TACTGACATA CGTAGGCTAT TCATTTATTT TAGCCCATCA GAGCCTGAAG AACTGATTTT TCTTTTTTTG GCCTCTGGTT CAGAAAGATA AAATTAAGAG AGAAAAAGAG ATACTAAGAC TGCTTGACTA TCATGGTCTT AAGTTAGTCC CATGGCTTGG AAAAGTTAAA CAGGGAAACA AGATGAGAAA TCCATTGAGA TTTCTAGAGC TTTATTGTTT TATGGTCTCC CTTACAAATC ACCAGAGCCT CAGAAACACC CATTTCAAGC ATAGAATAAA AAAACCTCTC TCAACCCAAG CAGGTACTGG GTTGGCAATA TACATTGGCT GAGAGAACAA ATTGTATTAA AAACAAAAAC AAAAAAAAAA CTTTCCCTGA AGTTTTGAAA ATGTAAGTTG AATCAAAAAA CAGAAGCAAT GAGGGATGAG TTACAGAACG TTCTGTGCAT TCTCAGAGGG ATTTACCATT GCAGGCTGGA ATAGGAGCAC TCCATTCTCC AGAGGACATA CACTGCATGG TCTCCATGCT GCTTGGCAGG TAACCCCTAT CACAGCTGAT AGAGCAGGAA GAATTGTAGC TGAAGTTTCC CAGTGGGTGA CTGCAAACCA GGCTTCCATG CTCAGGGGAT TCCAGGGCTG TACAGTTCAC AACTGAAAAA GAAACCCAAA TCAGTTCTGC TCATCTCTCA CCTTTAACAG ATAAGAACAC TGGAAACTAG AACTACAGTT TGGTTTTTTT TTTTTTTAGT TTAAAAATTT ATAAAATTTC TAATGGAATT TGTAAAATTG ACTGTAATTC TACCCCTTTT CTTTTATTCA AGAAAATGCT GATCCATAAC AACAACAACA AAAAAGCAGT GATGACAACC ATAAAAAAGA AATATTGAGT GATATGGGGA GAGTAGTGTA ATTGTGTTTA CCTCAAAACT GTTCAAATTA TATGAACAAA CACAGCAAAC TTAGGTACCA CAACAAATTT CTTGTTACTT TTCTCACAAC TGCTAAAAAT ACTACAGTAA GCTTCCAACC AGGATGAGAA CCATTCACAA AGCTATATTT CAAATTTAAG TACTAGAATA CATTACAAAT TTTAAAACCC TAATGCTGCA CTGTCTACTA TAGTAGCCAC TATCTGTGTG GCTACTCAAA TTTAAACTTG AATTCGTTGA AATCAAATAA CATTTAAAAT TCAGTTCCTC AGTGTCACCA GCCACATTTC AAGTACTCAA TAACCACATG TGGCTCATAG GTACACACTG GAAAACACAG CTATGGAACA TTTCCATTAT CACAAAAGCT CTACTGCACA ACGCTGTGCT AAGGAATCTT GGAGAGAAGC TCATCTAACT CTCTTAATGT ACAAATTTAG GAACTGAGAC CTCATTTCAT TCAAGTGACT TGCTCCATGC TACACGGCTA GTCATTACAG AGCCAGAGGC CAGAGCATGA ACCAAGATAC CCTGGACTCT GTAACTCACT CATTTCTACT GCAACGTCTT GTTACCACCT AGATGAGGTG AGTACATGTT CCTCGCAGGG ACACAGAATT ACAGTTTATT GAATGTGTCC TGTGTGCCAG GCACCATGTA ACCATGAGCC TATGAAGTTC ACACTATTAT TATCCTCATT TTACAATGAG AAAACTGACA TAGAGAGTTA AACTATCTTG TCAAGGTGCC AAAATAAATA ACTGGTGAAT CTAGGACTCA AACCCAGCAG GGTCTGACTT CATAGTCTCA GCTCACGATC ACCATATGAC ACCATCTGCA CCAGGGAAGG GAAGGCATGC AGACCTGACT CTAATGCCAG CTAGGACGTG AGATGGTGCT ACCATCTCAA GTGAAGAAAG AGGCAAGAAC CAGACTTACT TTGCTCACAC TTGAGTCCAC TGAAGCCAGG GTCACACTTG CAAGTGTAAT TATTGATGGT CTCTACACAT TCACCGTGGC CACTGCAGGA TGTATTGGTA CAGGCAGCTA CGGAAAATAC AAAGCATGAT GAGGAGGACT ATTACTGTGC TTATACTGAG TGCCTTTGAT TTTAGAATCA ACAGTGTGCA ACAGAGACAT CAGCAGTCCT ACAGAGTGCC ATAGACTTTA ACTGAAGTGT TTTACAAAGT TCCAAATCTG AGTTTCAGGC CCACCTATCC TAAACCTTGA TGCTAATGTA TAGCTGTGGC TGGCACCTAC CGTAGAAAAT TTACTTCTTC ACAAACTCTG AAGACAGTTC CCCTACCACA AATAAACAAG TAATTAAAAT ATGTATTGTG TGTGTGCATT TTTATATGTA AAGAACTACA TATTTGCCTA CAGTATTTAT ATATATTTTA TATATATACA TACACACATA TATGTGTGTA TATGTGTGTA TGTATATATA TAAAATGTAT ATAAATGCTG TAGGCTATAT ATATATACAC ACACACATAT ATGTGTGTGT GTATATATGT GTGTGTGTGT ATATATATAC ATATCCACAT ATTCTTGCCC ACATTCACAC AAAACAGCAA AAGAGAGAAA CTTTAGCAGT TAAACAGAAT CTTTTGGAAC ATAAAATGAC CACAATAGAG AGCAGTTTTT GCATGCTGTA AATTTGCCAA GATGCCCACA CACTGAAACT ACCTCCCACT GCTGCCGCAA ACTCCCTACC TGTGTAGCAT AGGGCAAGCT TCTTCTTGCT GCACCTCTCA TCATTCCACA TGCCCACATC TTTTTCTCTC TTGATGTAGA TCTCCACGCA GTCCTCATCT TTTTGCCTAT TGTTGGGTTC ACCTGGAGCC CAGTTCTTGG CTTCTTCTGT CAGAGGTTTC TGGGTTCCTA CCCAGACCCA CACATTGTTG ACTTTTCTGA TTCCAATCCA GTAATAACTT GGTGAATAGC TCAATATGGA GTTTAGGTAC TCAATCTCTT CTTTGTTTTG AATTGCAACC AGGTGTGTGT ACCTTTGCTG ACAATAAGCA CTGGCCTCAT EPI-109 60

CATAAGTCAT AGCTTCCGTG GAGGTGTTGT AAGACCAGGC TCCACTCTCT TTAATGAGAA GCACTAGTGG GAGAAAAAGA AAAGAAATGG TAGAGTTTGG TACTGTTGTG GTTTAACTCT GACAACTGTG CTTTTTATTG TCTTATTTTT GGCAATGTTT GTGACATGGC CCAGACTTTT CTCATCTTTT CAAAAGTAAG AAGTACGTAT GAAGAAACAG CGACTTATTG TTTATCTCTT TTGTGACTGC CACCCACTAG GTACCTTATC CACACTCACT CACAACATTA TAGTATACCC ATTTTGTAGT AGAATAATAA TCAGAATAAC TAAGCTTTAT TGAGCACTTA GTATGCACCA AGAAGCACTG TATGAGGTAC TTTCCATGAA CCATGCTATT GAATCCTCAC AATGCATCTG GGAAATAGGT CATTATGATC CACACTTTAC ACTTAAGGAA AGGGAGACAC CAAGAGGTAA AGTAAATGAC CCCAAGCCCA GGGAAGAACA CATTGCAGGT AGAGGTCAAG GATGCTGCCA GATATCCTGT GCAGGACAGC CCCAGACAAG CAAGGATATT TCAGTCTGAA ATATCTATAG TGCGAGAATG AGAAATCTTG GTCTAATGGC ACTGACTTAC CCAAAGTGAG AGCTGAGAGA AACTGTGAAG CAATCATGAC TTCAAGAGTT CTTTTCACCC AAAGGTTTAG GCTTGAAATA CTTTCCTGGG GAGATAAAAC ACAAAATGAA TTAAAGAAGG AAATCGTGGG TAGCTAGTTA CATTATTCTA CCATGATGTT TAAGGCAGCA TCCTAAGATT TTGGGCAAAG GACACTAGTG CAATAATCTT TATTTCAGAG TTTAATCAAA TAAATAAACA AATTTTAAGA CTTTCATTAT TTAGGTCAAA GAGAAAAGAC AGGTTTTAGC TACAATACAA TAAGAGCTTG TACAGATGTG GTTTTTATTA GAAGGCCTTT TGCATATCTG TGTTTCATGG CCCGAGGCTG CCCTTATAAA GCGTTCTGCA CTTACCGTTT TGGGAAGCAG TTGTTCAAAC ACAGGATCTC TCAGGTGGGT ATCACTGCTG CCTCTGTCTC AGGTCAGTAT AGGAGTTTTG ATGTGAAGTC AGCCAAGAAC AGCTGAACAC TACTTCGGCT GAGGCCCTTT TATAGGAGGG ATTGCTTCCT GTGAATAATA GGAGGATATT GTCCACATCC AGTAAAGAGG AAATCCCCAA TGGCATCCAA AAACTTTCCC GGGAATATCC ACGATGCTTA AAATTACAAT GATGTCAGAA ACTCTGTCTC TTGAAGCTAC TTCACCTTTG TCCATGCCTT TATATCGTAT ATGCAATTTT ATTAATATGA CAAAAATGCA TGATTTTTAA TTATAATAAC ATAAAGTCTA TGTCTTTAAA AAGTTGTAAA ACTTTGCTTG TTAGTAGTGT CTCTCATGTA GTTGTGGTAG TAATTAGAAT TTCAGAAACA GAAGGAAACC AAGAATAGGT TTGTCATCCA TAGTCTACTA CCTTCAATTT CTCATTCATA GCTGTGGATA ACCAATCACT ACTCATTTTT TCTTCCTTTT TCACCTGCCA ATTCAACATA TTTAACATGC ACTGTCTCAC AGAGGAATGA CTCACAAGGT AGATATTAAT CTTCAGATTT TGCACGGCAG TTATGCCTAA ATTAAAATAT TATCTAAAAA TAATATCTAA CACTCAAATG GTTAAAATAA TGCCTTATTT TAAAAAAAGA AAAATGGGAA ATAGATATTT ACATCTGGGA AAGTTTCATG GTTTGTTCAG TGAAAAAAAT AAAAAGGAGG CCAGGCACAG TGGCTCACGC CTGTAATCCC ACCACTTTGG GAGGCCGAGG CAGGCGGATC ACCTGAGGCC GGGAGTTCAA GACCAGCCTG ACCAACATGG AGAAACGCCA TCTCTACTAA AAATACAAAA TTAGCTGGGC ATGGTGGCGC ATGCCTGTAA TCCCAGCTAC TCGGGAGGCT GAGGCAGGAG AATCGCTTGA ACCCGGGAAG TGGAGGTTGC AGTGAGCCAA GATCACGCCA GTGCACTCCA GCCTGGGAAA CGAGTGAAAC TCTGTCTTAA AAAAAAAAAA AAAAAAAGAA AAGAAAAGAA AAAAAATAAA ACGGAAAACT ATATATATAT ATTTAATTGG TCAAAATTTT GTTTAAAATT TTTGAAATGT TAATGTGCAA AGAATAAAAA TTCTTCCACA ATGTTAACAG TGACTAACTC TGGATGGCAG GATTTGGGAT AATTTTTATA TCCTTCATTA TTATTTTCAG GATTTTAAAG TTTTTTTCAA TTTCCCTTTT TTTCACCTTT ATAGTAACAA GAATACAGTT TAAAGAAACT TGTCTCTAGG CCAGGCATGA TGGCTCATGC CTGTAATCCC AGCACTTTGG GAGGCTGAGG TGGGTGGATC ACCTGAGGTC AGGAGTTCCA GACCAGCGTG GCCAATATGG TGAAACCCTG TCTCTACTAA AAATACAAAA ATTAGCCGGG GTGTAGTGGC GCATGCCTGT AATCCCAGCT ACTGGGGAGC CTGATGCAAG AGAATCGCTT GAACCCAGGA GGCAGAGGTT GCAGTGAGCT GAAATCACAC CATTGCACTC CAGCCTGGGC GACAGAGCAA GACTCCATCT CAAAAAAAAA GAAAAAAAGA AAAAGAAAAG AAAAGAAATT TGTTTCCAAA TGCAACAGAA GGAGATGTAT GTGGTATCCT ATATTCCTGC TCTTCATTTT GACATTTCTT CTGGGTGATT GTATACATTC CCCATCTCTG CATCTTACCC TATCTAAATG ATGGTAACAG TAAATGGGGA TCATTTTAAT TTCCATATTC TGTAGGTTTT CAGAGCTCAA GTCAAGCTAA TATTCTATAT CTACAGCCTT TCAAAATAGG AGGTCTATCT AAAAATGTAC TGTCAGCAGA CCTGAACGAG TAGTGGTAAA AGCCTCGTTT TTCTCTTTAC TTGTTAGCAC TGGTCTTTCT GTGTTCATAA AGATGTCAAG ACCCAAAAAA AAAACAAGAA AAGAGAAGAA AAATTCCAAA AAAGACAACT GATTAGAAAA AAATAACTTA ATTAACGAAT TTAATTCAAC CCCTATCAAA AAGCATAGAA TTTATTCCCT CCACCTTACC ACTCTCTTAC ATGATCCAGA TACTGACATT ATTCCAATTC TTTATCCCAC TTTACTTAGC TCAATGTGGT TGTTGCTTCA ATAAATTCAG AAGAGTAATC ACTCATATAG TGTTTATTTA GATTTTAGGG CAGAATGTCA AGTTGGGTTA ATACATTATC TGTATGTATT TTATTTTTAA TAAAGTATGA ATACATAATC TGCTATTTTT AAAAAGCATG GTCAAATGTA TAGAGTAGCC AAATCTTAAA AAACAATTTA TCTTCGATAT CAATAAAGTA CCTAATAATT ATATTGCTAA TAGAAATTAG TCGTTAACAT CCCTAGATAA CTAACTTTAT TATTGCGAAT TTTTCATAAC TAAGTTTATA GTTTATCTCT TCCCCTTTTT AAAATTAGTT CAAAGATATC TAAAAATAGC CCCAGTGGTG ATGAAGTTTC TATTTTACTT ACATATATAT GTCCTGGACC CCCAATTATA ATCTCTAACA TTTATTGAGT GCTTACTATG TGCCAGGCCA TATTCTGAGC ATTTTGTATG TTCACCTATT GATTATTCAA TCCGTACAAC AGCCTATGAA ATAGGTACTC CTATTATCCC CATTTTACAG ATGAGGAAAT TGAGAATCTG GGGATTTTAT CTCATTCAAA AGCACAGAGC TAAGGGTTGA AACCAGGCAG TTGATATCCA GAGCCCACTC CCTTACCTGC TACTCCAAAC CATGATTTCT TTTGTTGTTA TGCCCCGAGA TTCCTTGTTC TACCCAAGTT TCCTGTACTC TTCTTGCCCT CTTCTTCCTG AGACATCCTT GACCATCACA GCTCTCCACT GAGATAACTG TGTCCTGGGT TCTGAGACAT GGGGGCTGGA AGGGACCCCA GGGACAGTGA GCAGTAGGGA GAGGATGCAG TGAGAACAGA CCCTGGATCC CCGGTGCATA GGCAGGGAGA AAGTGGACAA AGGAAAAAAC AAGCAAGGCA GGTGGAGCCA TGCCTAGGTA AAGTTGATCC CTAAGCCACA GTTCCCAGAA GTTCCTGATT CAAAAGCAAA TTTTCTCTAA GGTCAAAGGG CAAACTGATT ATTCTAAATT CTAAACTGAT TATTTCTAAA TTGAGAAAGC TTCAGGGAGA GATCCCAATA TTCGAAGGAT AAGAGAAATG AGGAGTGGAA GAGATAGGTG AGTAACAGTA ACTTAAATGT AGACTATATA TAATATATAA TATATGTAGA GTATATATAT ATAATTACAA TATATTATAT ATGTGGAATA TATATATTAT TTATATATAT TTATATATTT TATATATATA GATATTTTTA TATTTTATAT ATAAATATAG ATATTTTTAT ATTTTATATA TAAATATAGA TATTTTTATA TATATTATAT ATAAATATAT GTAAAATACT GTGAAAGAAG AATAGAATCT TGAGACCTCA AATTCACTAT GCCAAAGGGA AAGTTAAGCT TGGGAAATGA GTCATGCAAA AACTGCCTTC CTTTTGTTCC CAAATACCTG TAATTTCACA TGCTTACTTT ATCTTATATA AAATGTAGAT GTACTGAGCA TGAGATCCAT GCATAATTTC CCTCTAGTCC CTTCTTTTTA CATGTAAAGT GTAGACTCAC TGAGTGTTAC AGAGCCTTGC CACAATGTAA ACACTTGTCT CATTGCCAAC CCATCTTTCG TTTATTTTCT TCCCCTCCTG CTTGCTCTTT CCCCTCTAAA GATGGAAGTT CCCAAAACTC TCTTTGGAAA AAGCGCAGGT CACAGATCCT ACAGTGATTT GTGTTTCTTT TACCTGGGAC AAAATAAACC TCTAATCTGT TGAGATATGC TTCAGTTACT TTTTGGTTTA CAATATGTAC ATGTATGTAT ATAATTTATA TGTATATAAT ATATGTACTT GTTTTAACCA GAGGTATGTT ATTCAAAATC CATTCATCCT TACAATTACC TGCATTCTCC CACAGTATTT TCTGTGTCCC TGCCCCCGAG GTTGTCACTG CAAATCAGGT ACATGGATAC TGGGAGCTGA TGGGCTCCCC TCTGGCTACC TGGGCTGCTG AAGGGGCCAT AGACAGACCC AGCTTTCCTC TCGTGGAGAG GCCCTGGGCC AGCGCTGCGT GGGAGTGGGA TTACAACCAG ACTATAGCTT CTTCACCTGC TTTTTCCTAT CAGGATTTCA TAAGAGGCAA TTGCTTGTTT TTTGAGGGTG GGGGCAAATC AGGGGGAGTT GAAGAGGAAA TTGGGTAAGA TTTGAATAGT TGGGCATGTT GAATATTATG AATATCATCT CCCTCTTCAA ATAATCCAAA EPI-109 61

ATATACCCCC AAGAAACAGG CTGATTAGAG GTGCTTCAAG GCTCCACTGA ATCTCCCAAG CTCTGAAGAT GTAGCTAGCT GTTACCGGAT TGCCGGTTTT CAAGCCTCGC CTCACATGGA CCCTCTTGGC AGTTTCTCGC ATGGGGGAAG CATCCGCTAC ATAGATGGGA ATGAAAAGAG GAAAGAAGAC GGTGCAAACT CAGGCACACC CCGGTGTCTG CCACCAGTGC TATTTAATCT CTGAGGTGTC ACCCTTCCTG GCTTTATTGT CTCTTCCTGG AAGTCTCTTG TCCTCTCCTC CACACCCTTT AATCAGGCAT CAAAGACTTT AACCAGTTTT GCTGTGTGCC CAGGCCCACT CATTCTCACT TTTATGGCAA AGGGAGTGGG AGACAGAGAG ATAGCCAGAA AGAAGAGATT GGGGACCCCA AGACAAATGT TAGAATTTTA ACCAAGGCCA CCCTGTGGAC AGGAGATTAT TGGGTTTAGT GGAAAGCAGC ACTGGCCACA ACCACACGTG GCAAAAGCAT CTATCGAGGA GTGAAGTTAT ATTTGGTGAA TGTGACCGGG AAGCAGGGGC AGTGGTGTCC TCCTGCCTTC CTGAGGCACT CTGTTCCCTT ACCTCTGCGA AGGCTTATTT TACCCCTGAG TGCTTAGTTT TGAAAGCCTT AGTTCCCTCT CTCCCATAAA AAAGCTCTAC TCTGCTAACA TCTAAGTTAC CTTTGCAGAG TCTTAGGTAG AGGGAGGAAA TCCCAATAAA GATTCCACCC TATCTGCAAA ATACAAACAT GGTATTTCTT GCATTCCCAA AATTGTGAAA GAAAATGTGT ATCACCACAG TAGAGAATGG CATTTTTTGT TTGATCAAAA CCTAAATATA TTTGATGAAA ATGTGTCTGG TTCTAAGTTT ATTTCCCAGA AAGCCATGTT TACTCACTTG GAATTTATAG ACATCTTATA ATATCTGAGT CGAGTAGGAG CTCCGGGCTC TACCTCACTC TTTTCTCCCA CACCCAGGGG GAAGTGTAGG GTTCTCAGAC TTTAGAATAA AGAGGAATCA CCTGGACAAC TCACCTAAAA TGCACATCTT CAGGTCTCAT ACTCAGAGGC TCTGACTCAA CAGGTCTGGG TGGCGCCCAA GAATTTGGGC TTTAAATGAG TATCTCAGAT GATTCTAATA CAGAATGTGT AAGATGACCA GATCCTATCA CACTTAGATG TATTGGCCTA GGGCCACCTA ACTTGGAGAA AATGTTAGTA AGACCCCGTG GTTGGTGCTC AGCTATAGGT ACCAGAATTT TGATCAAAAT TTACTATCAT TGTGACACTT CTCTTCGGAA CTGGAAGGCC AGAACCCCAC TTGTAAAGTG CTGGGAAAAT ACAAGGAAAA TTTAGGGTGA GTAGCATTTT GAATTCTTAC ACATGGAAAG TAAATGTATA AGAATTCTTA CCAATAAAAA AAAAGCAAGA GAGAATAGCT GCTAAAGAAT TAACACAAAT ATGTATATAT TAGTTATTCT CTITTCTCCT CTGATTCCAG AGGACTTTGT AATTCCACTA ATTCTTCTTG AGCTTCCAGG ATGATCTGAG ACTTGAATTT TTCATGTGCT TTTTGCTTCC TATTTGGCAG CATCTTATCT TGAAGTTTCC GCTTTCTGCT TGGGGACCTA AAAACTAACT AATGGGAATT TCTTCAAAAT GAGCAAACTC TGGTGAATTC CCAAAGCGGA AGAAACAAGT GAGGATCGGG CTGGTTAATT AAGAGAACTT TTCCTGAATG TAGCCAGACT GTTTGCCGAC TGTTGTTAAC ATGAGGGAAG AAATACCCCT GGATTTTAGA AGAGCCCCTT GTTTGTTTTC CTTGGCCATT TGTGCTGCTT GTTTTGTAAG TCAGAAATTT CCTGAAGGAC TATTATTAGC TTTGTTCTCA CGTCAGAAAA CTTCTGCTCT GGCCACTTTT AAACATATAA CTTGGATTTT ACTGTATTAG AAAATGTAAC AATTACAGAC AGCACTAAAA GGACACCAAA GGGCAAAGAA AATGGGTAAC TTTTTTTTCT TCCCCAAATC TAAAATAGGT GATTTTGGAG AAGTAGGAGA AAAACCTGGA TTTTCTAGAT CTCTTTAGAG CTCAACAACT GATATAGTTA ATTATGTAAG TCTTTGATAT TTGGAAATGA TTGGATTAAC CGGATAACAA TGAATATTTA AATACAGTGA TTTGGCCAGG AGCAGTGGCT CATGCCTGTA ATCCCAGCAT TTGGGGAGGC TGAGGCGGGT GGATCACCTA AGGCCGGGAG TTCCAGACCA GCCTGGCCAA CATGGTGAAA CCCCATCTCT ACTAAAAATA CAAAATTAGC CAGGCGTGGT GGTGCAAGAC TGTAATCCCA GCAACTCGGG AGGCTGAGGC AGGAGAATTG CTTGAACCCG GGAGGCAGAG GTTGCAGTGA GCCAAGATCA CGCCATTGCA CTCCAGCCTG GGCAACAAGA GCGAAATTCC ATCTCAATAA ATAAATAAAT AAATACAGTG ATTTAACACA AGAGATTTCT ATTTCACACT AATGAGCTCT GTCACTGGGG CAAGCTTCTT TGCCTCATTA AGTCTCAGAT TTCCCGAGAG CTTATTTATT TATACCAAGA GTGCTTTACT ACCGTCTCTG CTAGCTGTGA CATAATATGA CAAAAGGTAT AAATATGGGA AAAGGCACTA ATTTATATCA AAGCGTTCTT CGTTTTTCCT TGCTGTGAAG TTTTTAGCTA ATAATTCATA AGAATATACC ATATTTAGAG TGTTTACTAT GCATGGGCCT GGCACTTCAC ATACATTGCT TCTTACAAAT TTTACAAAGT GAAAGGTAGA TATTAATCTC ATTTTATGGA GGACAAGATA GAGATCTGGA GAGGTTACAT AACTTGCCAG TGTTTTTTCA GTTAATAAAT GGTAGGGTGG AGATTCAATC TGTGTTACTC TAAAGTCCGT GTCCTTTTTA TTGGCTCCAT GCCTACTCAG ATTTAAATCT CAGCAGGGAA GTAAACCTTA GTTTTTACAT GAGAAAATGT TACAGCAGCC TTCTCGGCTT CCTTTACCCC CATCCCAGTT TCACGAGCTT AGTGCCTTAG ATCGGGTTCC TTTAGAAGCA GACCTCGAAA TAAGGATGTG GGTGCCAGTC ATTTATTGAA AAGATGATCC CAAGAAAGCC TAGTAGGAGA GTGAGGAAGT GAGATGGGGA AAGGAAGAAA CTCCACAAGA AGTGTGTTAA TAAGCAGGTT ACCGCTGTGG GCAGCCATGG GGCTCAGCTG CACTAACAAA CTCTGTCTAG TACAGAAAAC CTCAGGGTCT CCCCAAGGAG GGGCAAGAAG TCTGCCTAGG GTATATATCC GCCAACTCAG TCACTGGCTG AGAGCTGATC CTGGGAGGGC ATGGTTAATT CCTCTGCACT TTCAAGTGGA TTCCTGTGGT CAGAAAAAGC CCTCTACAAT GAATTCCAGA TGCTTGTATT TAAATCTGAC ATGATCTGAA TGCTGTGTTG GGACAGGGTG GGCGTTATTA GTTTTCTGTC ATTACTGTAA CAGATTACTA CAAACCTGAT GGCTGCAAAC AACACATATT TATTATGTCA TAGTTTGTGT GGGTCAGAAG TACAGGTTAG CTCAACTAGT TTCTCTGCTC TAGGTTTCAC ATTGCCAATA TCAAGGTGTC ATCCAGTTGG GCTCTTCTTG GGAGGCTTGG GGATGAATCC ACTTTCAAGC TCATTCAGAT TGTTGGCAGA ATCCAGTTCC TTGTGGTTGC AGGACCAAGG TCCCTGTTGC CTTGCTGGCT GTTGGCCAGG AGTCATTCTT AGCTTCTAGA GACTACCTGT ACTCTCTGAC TCGTGTCTCC ACTTCACCTT TCAAACCAGC AGCGGCTAGT CGAGTCCCTC TCTTCAAATG TCTCCAACTG TGCCTTCACC TCATTTCTCC TCTGTGTACC ATGTCTGCCT CTACTGCTTG TAAGGGCTCA TGGGATTACA TTGGATTTAT TCAATCCAGG ATAATCTCCA TATTTTAAGG CTAGCTGACT AGTGATCTTA ATTCCATCTA CAAAGTCCCT TCCAATAGTA CTGTATTAGT CCATTTTCAT GCTACTGATA AAGACATACC CAAGACTGGG CAATTCACAA AAGAAAGAGG TTTAATTAGA TTTACAGTTC CACATGGCTG GGGAAGCCTC ACAATCATGG CAGAAGTCAA GGAAGAGCAA GTCATGTCTT ACATAGATGG CAGCAGGCAA AGAGAGAGAG CTTGTGCAGG GAACTCCTCT TTTTAAAACC ATCAGATCTC ATAATACTTA TTCACTATCA CAAGAACAGC ATGGGAAAGT CTTGCCCCCA TGATTCAATT ACTCCCACCA GGTCCCTCCC ACAACATGCA GGAATTCAAG ATGAGATTTG TGTGGGGACA CAGCCAAACC ATATCAAGTA CCTAGATTCA TGTTTGATTA AACAACCAGG GAGCAGAAAT CTTCAGGAGT GGGGGGCATC TTTAGAATTC TGCCCACCAA GGCTGGGCGC GGTGGCTCAC ACCTGTAATC CCAGCACTTT GGGAGGCCAA GGTGGGTGGA TCATGAGGTC AAGAGATCGA GACCACCCTG GCCATGGTGA AACCCCATTT CTACTAAAAA TACAAAAATT AGCCAGGTAT GGTGGTGGGC ACCTGTAGTC CCAGCTACTC AGGAGGCTGA GGTAGGAGAA TCACTTGAAC CCAGGAAGCG GAGGTTGCAG TGAGCCAAGA TTGCGCCGCT GCACTCCAGC CTGGGAGACA GAGCAAGACT GTCTCAAAAA AAAAGAATTC TGCCCATCAT AGTAGGCTGT CCTACAGAGA CATAACCCAG GAATTAGGTG AATGGCTAAC CTAAATTAGC ACTGTGATGT GTTTTCTGAC TTGGTCCTTA TAGCTCCTCT GCTTAGATGT GGAACTAATC CATGAATGCA AGGGTTTGTC TAGAGTTTTA AGTGGGAGTT AAATATCCAA AGTACAGGAG ATATTATGGG TGCCTCATCC ATGTCCCCTT GGCATTTATC TTTCTTGGAT AACCCAACTC TATTAGTTTT TATATCTCAC TTGTTCCTAT ACTCTGTGAA CTGATGTCCC ATAAATAGAC ATTTCATTTT GCCAGTCTTC TTGAACAATA ATTACGATTA TTAATCTAGC AGTTATCATT AATTGGCCAC TTCACATTAG ACACAGCACT TAGGACTTAA GAATACCATG TCATTTGATC ATCATAATAT GGTCAGGAAT TAAGTATTGC TATCCAAATT TTACAAAGAA GGCACTGAGG GTTAGAGTTT AAATAACTTG CTTAAGATGT CATAGCCTGT AAGTGACAAA ACTAGGACTC AAATACAGGT CCATCTGACT CCAAAGTCTA TGTTCTTGGC TACCACACTG CCTCTCCTAC AAGTGACCTG TGGTTTTACT ACTATATTCA CACTCTACTA ACTTTACCAT CTCCCATGAG TCTGTCTAGA GGAGGGCACA EPI-109 62

CACAGCACAG AAAACACATG AATGCAAAAT AAGGAAGGGC CTACTTACTA CACAGAGCCA TTCTAATACC TGATGTTTGC TCTAATCCAG TTTTACTATT AATTAGTTGC TGGTGCCCAA GTTTTTACTG AGAAATGGGG ATAATTTTGG AAGTCATAAT GATGCCTTCT TCTCATAGGG TATTTTATTT GTTGTTGTAT CTCCAGGCCC CAACACAGCC TGGCTTTTAG TAAATGATCA AAAATACCTG TTGAATGAAT AAATGGAGTC ACCTGAAACA TGTTAAACAT TTGTTCATGT GTCCTAATCG TGGATTTCAG GATAGTAAGC ATCCTAAAAG GAAAGCATGC ACACTGTTCT TGCTACATTA ATTTCTCACA ATATAAAAAA AGAAAAGCAT CTGAAAAAAG CTGCCAGCCG CTGTGTCTCC TAATATCAAA CTGAGCACAG ATATGGAGAA GCTAAGGGAG AGGGATGATG GGCCATGCCT CTAACCTCAT CATGGCAAAA GTCCTGGGGG TCAGACCCGA GGAGAGCAGG AAGTGTCTTT TGAGGGATAC ATTTCCACAG TGGAAATAAT GAGACTTAAA TAAATATTAT ATACACAGTT CAACTGTTTT TATGTGTAAA GGTAGTAGGT TTTCACAGTA AGGAAGCACT TCTTTTTTTT TTTGTTTGAG ACAGAGTCTC GCTCTGTCTC CCAGCCTGGA GTACAGTGGT GCTATCTCGG CTCACTGCAA TCTCTGCCTC CTGGATTCAA GTGATTCTCC TGCCTCAGCC TCCCGAGTAG CTGGGACAAC AGGTGTGTGC CATTACACCT GGCTAATTTT TGTATTTTTA GCAGAGATGC GGTTTCACCA TGTTGGCCAG GCTGATCTCG AACTCCTGAC CTCAGGTGTT CTGCCCGCCT CTGCCTCCCA ATGTGCTGGG ATTACAGGCA TGAGCCACTG CACTCACCAA GCACTTCTAC TGATAGCATT TACAAACCCT TCTTAGAATA TTTAAAAATT CTAAGAGAAG AGTAAATTGA GCCTTCCCAA CTAATACTAG GAGGTTATAA CCTTCATACC AAAACTGGAC AATGCTTGCA CAAAAGAAGG AAGCCAATGA GGCCACCTAG AAGGAAGACT GGGCATTGGG CCCAGTGAGT CCTGGAAACC TCATCTGTGC CAGCCACCCC GGCATGGCCT GTATGAGTGG ATGAGGGTGA CTTGTCCACA GACAATAGCC ATCTAGCTGT GATAAAGGAG TCAAGGTAGT CAGCTGCATC TCTTTCACCT GTTTGCCAAT GTTACACAGG TTGAAAAGCT AAGGTTTATG TAAAGCAAGC ATCAAAGATG ATGAAATGAT CAACCTGACA ATGAGTACTA TGCTGCATTG TCCAGAAAGG AACTGTGGAA GATTTTGGGC TGAATTTCAA AACAGAATTT CCTCACTCTC TGGATGTTGG CTTACTTGGC CTTTGATGTT CAGAGGTGGT GCCTTTGTGT TGTTGAACAA TGTTGATTTT GGAGAGAAAA CAGAGTTGAA AAACCCACAA GTCATTCCCT GGGGAGTATT ACCGGAATAC AGAGGATAAT TTCAGCAAGC CAGCAAGGCC TCATCTCTGC TTCTAATAGA TAGGAAGAAA GGAAGAGAGG AACAATACTT TTTTAAGAAG CTCAGCTTTA TCGCCTTATC TCATAGAAAG ATGCCTCCAG TCTGTCTGGC TAAAGGTAAT TGGCATGGGA AAGTCTTTAT CTGTGATTCT AACAAGTGGA ATGTTTCCCT TCATTAAGAG AGCCTTGTCT GGCTTGGGGA AATGAAACAC TTTCTCCGAT ATGAGTGGGC TGTAACCCCT GCTACTAAAT ACTCAGAAGA AATAAGGCGG TTGTGGAGCA GTCAGGAATG AGTCACTTGC CTCCCTGGAA TATTCAGAAA ACTGAATCAA AAGTACATTC TTCTGGGTTT TCTTAGTCTA ATAGACTAAG GGTCTCTACT TTGTTAAATT TCTGGGAAAC AGCATAGAAT GGGAGAAAAA ACTGGTCACT GTAGTCATGC AAATCTGCAA AACAAACAAA AAAGTCTGGG TATTGCTGCT AACTAGCTAT GTGACCTTAA GCAAGGTATT AACTCTCTCT GAATTTCAGG TTCTTCATCT GTTAAATAGC ATATCTGTAA AATGGGAATT ATTTTCATAT CATAATGCTG TAGCTTTAAA AAATAAAATA AAATGGATGA GATAATCAGA ATTAAAGAGC CTGGGATATA TAGTTAATAT ATAGCAGCAT GTAAAGATCC TGTTAGAAAT GCTAATTTTA CAGTTAACCA TTTGGAGATG ATCCGCCAAA GCTGCTAGTG TAGAGGCAAC TGAGAATTTG CCTGTCCTTC AGAATATGAA TAAATAACTG TCAATGATGT CTCAAGCCTA GAAAAACCTA TCCATCTGGA TGGGTGGGAA ATTTCTAGGC TAGTATTGAG AAGCCCATTT CTTGGGAAAT AGGTCCTGGA CTGAGTGAAG GAAAAGAAAC AGTAAAACCC ATGGTAAAGC AGCAAGGCTC TCTAGAGGCT CTGGAGAGGA TGAATTGAAT TCTAGAAGAT GAAGTAGGGA AGACGCTTTA CCTTCTTGTG AAATGGATTC AAAGATTCAA AGACCTTCGG GAATCTCCAA TTGTATAAAT GGCACCATAG CTGTATGTTC CATGGAACAC TACTTCCCAG AGATGCCCAG TGAAAAAAGA ATGCCACAGT CAAATAAGTT TGGAAACACT CCATTATGTG GCCACCTCCT TGAAGACTCT AATGCACATT AGCATGTTAA ACAGTCTTGA GAAGTCCTGC AGAGCAGAAA TTGCTTCACA TCTGCTAAGC CGGCAGTTTC CCAATATACT TGATTATGGA TAGTTTTTTC CTTACAACAC CATTCTCTGA TATGCTTCCA ATGACATGAA ATAAATATAT ATGCATGAGG TTCTTCATTA GGGCATACTT TTTAATAGAA AATATTGAGA ATAATCTAAA TATAAATGCA CAGCATTTAC CTTTTCTGCA TAAACTATAT ACAGGCATAC CTTGGAGATA CTATGGGTTT GGTTCCCACA ATATCTCCAA AACCACATTC GGTTTTATGA CCACTGCCAT AAAACCAGCC ACATGAATTT TTTGGTTTCC CAATGTATAT CAAAGTTACA TTTTTACTAT ACCATAGTCT ATTATATATA CAATAGCATT ATATCTAAAA AACAACGTAA ACACCTTAAT TTAAGGCTGT GGCTGGTTTG ATTTTCTACC CAGACCACTA AAACTTTCTT CATATCAGCA ATAAGGCTGT TTCACTTTCT TACTATTTTT TGTGATAGCA CTTTTCCTTT CCTTCAAGAA TTTTTCCTTT CTATTCACAA TTTGTTTGAT ACAAGAGGAC TAGATTTTAG CTTATCTCAG TTTAAGGTGT TTACATTGTT AGCTAAAAAT GCTAATGATC ATCTGAGACT TCAGCAAGTC ATAATCTTTT GCTGGTGGAA GGTCTTGCCT CAGTGTTGAT GTCTGCTGAC TGGGTGGCTT TGGCAATTTC TTAAAGTAAG ACAACAATCA AGTTTGACAT ATCAATTGAC CCTTCCTGTC ATAAATGATT TTTTTTTTCT CTGTAGCCTG CAATGCTCTT TGATAGCATT TTACCCACAG TAGAATTTTC AAAATTGGAG TCAATCCTTT CAAACTCTGG TGCTGTTTTA TCAACTAAGT TTATGGAGTA TTAGAAATCC CTTGTTGTCA TTTCAACAAT GTTCACACCA TCTTCCCCAG GAGTATATTC TACCTCAAGA AACCACTTTC TTTGCTCATC TATAAGAAGC AGCTCCTCAT CCACTAAAGT TTTATCCTGA GATTGCAACA ATTCAGTTAC ATCTTCAGGC TCTACTTCTA ATTCTAGTTC TCTTGCTGTT TCTATCTCAT TTGTGCTTAC TTTCTCCGCT GAAGTCTTGA ACCCCTTAAA GTCACTCATG AGGGTTGGAA TCAACTTCTT ACAAACTCCT GTTGATGTTG ATATTTTGAC CTGCTCCCAT GATTCATGGG TATTCTTAAT GGCATCTAGA ATGGTGAACG TTTTCAGAAG GTTTTCAGTT GGCTTTGCCC GGATCCATCA GACGAATCCC TATCTATGGA AGCTATAGAT TTATAAAATG TATTTCTTTT TTTGTGGGGG CATAGCGTCT CACCCTGTCA CCCAACCTGG AATGCAGTGG CACAGTCATA ACTCACTGAA GACTCAAACT CCTGGGCTCA AGTGATTCTT CCACCTTGGC CTCCCAAAAC ACTGGATTAC AAGCTTGAGC CACTGTGTCT AGCCCAAAAT GTATATCATA ACTAATGAGG CTTGAAAGTC AAAGTGACTC CTTGATCCAT GGGCTACAGA ATGGACGCTG GGTTACCAGA CATGAAAACA ATACTCATCT CCTCATACAT CTCCTTCAGA GCTCCTGGGT GAGCAGGCCC ATTGTCAAAT GAGCAGTAGT ATCTTGAAAG AAATTTTTTT TCTGAGCAGT AGATCTCCAC AGTGGACTTA AAATAGTCAG TAAACTATGC TGTAAACAGA AGTGCTGTCA TCCAAGCTCT GTTTTTCCAC TGATAGGGCA AAAGCAGAGT AGATTTGGCA TAATTCTCTA GGGCCTTAGG ATTTTTGGAA TGGCAAATTG AGCATTGGCT TCAACTTTTT TTTTTTTTTT TTTTTTTGAG ACAGAGTCTT GGTCTGTCAC CCAGGCTGGA GTGCAGTGGT GCAATCTCGG CCCACTGCAA GCTCTGCCTC CTAGGTTCAC ACCATTCTCC TGCCTCTGCC TCCTGAGTAG CTGGGACTAC AGGCACCCGC CACCATGCCC GGCTAATTTT TTGTATTTTA GTACAGACGG GGTTTCGCCA TGTTAGCCAG GATGGTCTCG ATCTCCTGAC CTCGTGATCC ACCCGCCTCG GCCTCCCAAA GTGCTGGGAT TACAGGCGTG AGCCACAGCG CCCAGCCTGT CTTCAACTTA AAGTCGCCAG CTGTGTTAGC CTCTAATAAG AGAGTCTGCC TGTCCTTTCA AGCTTTGAAG CCAGGCATCA TTCTCTTCTC TAGCTATGAA AATCTTAGAT AGCATCTTCT CCCAATAGGA AGCCATTTTT TATGCCCTAA AAATCTGTCG TTTGGTGTAG CCACCTTCAT CATTGATCTT ACCTAGATCC GCTGGATAAC TTACCACAGT GTCTACATCA TTACTTCTGC TTCACCTTGC ACTTTTATGT TATGGGGATG GCTCCTTTCC TCTAACCTCA TAAACTAACC TCCACTAGCC TCACATTCTT CTTTTACAGC TTCCTCGCCT CTCTCAGAGT TCACAGAATT GAAGAATGTT GGGCCTTGGA TTACACTTTG GTTTAAGGGA ATGCTGTGGC TGGTTTGATT TTCTATCCAG AACACTAAAA CTTTCTTCAT ATCAGCAATA AGACTGTTTC ACTTTCTTAC TATTTTTTGT GATAGCACTT TTCCTTTCCT TCAAGAATTT TTCCTTTCTA EPI-109 63

TTCACAATTT GACCGTTTGA TATGAGAGGC CTAGATTTTA GCCAATCTCA GTTTACACCA TGCCTTTTTC ACTAAGCTTC ATCATTTTAG CTTTTTATTT AAAGTAAGAT GTGTGACCCT TCCTTTCATT TGAACACTTA CATGATGATG CCTGGCTTCA AAGCTTGAAA GGACAGGCAG ACTCTCTTAT TAGGGGCTAA CACAGCTGGC GACTTTTAAG TTGAAGCCAA TGCTCAATTT GCCATTAGAA GCCATTGTAG GGTTAATTAA TTTGCCTAAT TTTAATATTA TGGTGTCTCA GGGAATAAGG AGGCCTGAGT AGAGGGAGGG AGATGGGGAA ACAGCCAGTC ATCAGAGCAC ACACAACATT TATCAATTAA GTTTATCACC TTGAGGGCAC AGGTCATGAT ACTTCAAAAC AATTACAATA ATAAAATAAA AAATCATTGA TCGCAGATCA CCATAACAGA TATAATGATA ATGAAAAATT TGAAGTATTG TGAGAATTAC CAAAACGTGA CACACAGACA CAAAGTGAGC ACATGTCATT GGAAAAGTGG TGCTGATAGA CTTACTTCAT GCAGGGTTGC CACAAATACT CAATCTGTAA AAAATTCAAT TATCTACATA GTACCATAAA AACAAGGTAT ACCTGTTTAT ATAATCAAGA CCAACAGAAC CCTAGAGAAA ATAGCTCACT CCCTAGCTCG GAGACATTCT AACCAACATA CACTTACCTT TCTTTTTGCT GTGTACAGAA TTCAAATCCC TGTCTCAGCA AAATTGCAAA GTATCAAATG TCATGTCCAT CTAATACTCA AAACTGCAAA TGTTAAGTCT TGTAAGCCCA GAGACCACTG TATATACAAG TGTTGCTATA AGCATTAGTT CTTCTCCAAA GAAAATAGTC CACTTGGTAG AAACAAACAA AAAGAAAAAA AAAGAAAGAA AAAACATTTT TTACAAGAAG ATTCAGTCTC TTACCTACAT AAGCAAAAAT ATGAGATGTT CTCTTATCAT TTTTCCATCT ATCTTATAAT CTTTGGTGCT GACTTAGACA CTCATTTTCC TTTTTGTACG TGACCATGTA AAAGTTCAAG TCAAGAAAAA CTTGTTTTGA CATTTGTTTT GCTGAGTGAT GGGTCCCTAA AAGAAATTTG GCTTTGCTTT TGAAAAGTTC AGCATGATAT TGTGTGAATT TTTCATGGCT AATGATTTTT AGAACAGTTG TGATGTGTTT AGGTGTTTTA AGAATATGAA GCATTCAGTG GTTTAAGTTG GTTGTTATAA AATGAAAGAA TATGAAGGAA AGCCTTCTTG TCTTAGAACA CACTGATTCA CAAATAAGCA GCTTCTCTCA AAATGTTGTA ATTACAAAAA TTCCAAGGCA AATATAATAA ACTCCTTGTC GGTGCTATGT CTAGAAACTT AACAGCCCCA AAGAAAGTCC TGACAAGGCA AAAAATATAT ATATATATAC AAATTGTGGA AGCAGGGTGT TGAAAGAAGA ATAAAGACTA TATAAGGACA AACTGTTTAA AAGGGAGGGT ATCCTTGAAA GCTTGACACT TGACTCTTTT GACGAGGCTG AGGGAAAACA CTCAGTTTCA TAGATTGCTG GTACGGATGT AAAATAGTGA CATCCCTATA GAGAGGAATT TGGCAATATC TAGCAAAAGT GCTTATGCAT TTATTCTTTG ACCTAGTAAT CCCGCTTCTA GGATTAGTGG TGAAGATACA CCTCAACAAT AAAAATATAT ATACATTAGG TTATTAGTTA TGGTTTAATT TTTAATAGCA AAATATTTAA AACAACCTAC ATGAACAAAT AGGAGACTTA CTGAATAAAC TATGGTATAT CTGTACAATA AAGTGCAATT CACTTATGTT GTTAATTTGT TCCAAAAATC CAGAGCCAAA GAGTATTTGT TATGCTCTCT TTAGTATAAG AAAGGGGAAA TAAGATATGT GTGCATCTGT TTATTTTTGT GAAAATAAGT ACAGAAAGGA TAAGTAAGAA ACTAGTAAAA CTAGTTATCT CCTAGTGTTA GTAGAAATAG AATGAAAGTG AATTAGGCTT CTTTGAGTAT ATGTTTATAT ATAGTTTTGA CTTTTGAATT ATGTTTATGT TTACATAGTC AAAAATATAA ATTAATCAAC AGAAATAACA AAAAAAGAAG AAATCACAAG CTTTAAAATT TAATACAAAC AGAAATAATT GAATCTAACA GTATATCAAA GTGATAACGT AAACTCAGAA GAAAAAAACA TAATCCAACA TACCAGTGGA ACACAATATT CTAACTGTAT ACATTCAGTG GTTATAGTCT AAGGACAAGA AAAATTGCAA AAATATCTTG AACTTTAGCT TGTAGGATTT TTATTGGTAG CAATACTAAT GTACTAATTC TGAAATTAAT GTTCGTGTAT TATAGAATTG AGTAAATGAA TAAATATGTT GATGTTATTG GGAACTAAAA TTATCATTCT GGGAGTAGAG AAATATAAAT ATGGACTTGG CAAATGAAAC AAAGACCTGC AGAGAGATAA CCATATAAAC TCATTATTTT AAAAATTATA AGTGTCCTAG CTCTGTTACT GAAAAGGCCT AGATTCAATC TTATCTTGAT AGACAGGAGG GCACCCCTTT CTCAGAACAT GGTTTCCAAA TGCCATTCTC CATTAAAAGG AACAAGGTCT TCTTGGAGAA AAGACTGATT CTAGGTCTGG ATTAGGTAAA GTACAACGTT AGTCTGGAAT TTCTTGCTGA ATCAGAAGTA AGAAAGTGCT CAAAAACATG GGAACATGTC ACAAACACAC GTGAGGCAAC TTGAATCCTC ACTGGCCATA TTTAGGACAA TCGAGCATCA AAAAAAAAAA AAATGTTGAG AATAATGGAT TCTAACACTT AAAACAAAAA ATAATCCATA GCCCACAGAA GGGGAAGAGA GGGGGAGCTC TTATTTACAG ATGAATATCA AATAGCAAAG ACAGAAGAAA TGACAGAATT AGAGAAACAT CATTTTGCAA AACACCACTG TAATAATCAA TTCAGGCAAG TATTATTAAT GGATGTATTA CTATTGCGTA AAACCAGTTG GGGAACAGGA TATTCATACA GTCTGAAGGT GTCACCCTAA ACATAACTTA TTACAAGTGG AAAATGGTGC CTTTACAATG AAGAAATCTA GCAGAAACCA TCTTAATCTA GTGATCAAAC TTAGTATCAC CAATAATGGA TCATACTGAG TCATGTGTCT CCTAATATGA TGCACCAGGA AGGATGCAAC GTCATGAACG TTGTATTCTT TTGTATTCAA CAGACCACCC AGGGTAAAGG CAGCTTTCTC ACTTACTAAT CAGAATTGTT GGTTTTAATT CATTTTGGAT TTTAAGATTT CTTACTTTCT TGTCAGCTCA GAAATTTATT TAAGATGATT TTTATCTTTT ATTCAATACT TTAGCTTGGA GAACCATTCA GAGTTTCTAA CTCATTGTAT TGCCAAAAAT AGAAAACAGC ATGGTTTCTT TTGAAAATGT CTAACTTTAA AGTTACTTGT GTGTGTCACT CAGATTCACA TAGCTTTTTT GCCTAGTAAT GTAGTATCAT GTGGCAAGGC TATAAAAATG TTTACAATCT TTTATTTAAT ATGACTCTTG AGAGTTTATT CTAAGGAAAT AATTGAATAG TAACAAAACA CTATTAACAC AAAGCATAGC AATTTGATTT GGGCAACCAA ACACTGGAAA CAACCTAAAT GTCCATTACA GGAATCATTT ATGAAGCAAA CACTAAAATA TTTATTGTGA AGATTATGAG AACATAGAAG ACAGTTATGA GAGTAAATTT GAAAACCTGA ACACAAAACT TACATATACT CCAATTGTAA CTTATAAAAA ATACGTGCAT ATAAGGATAA AACAGTACAA ACAAAAAAAT AGTTGCGTTA GATTGGTAGA ATTATGGCTC CTTTTGCTGT CTTAATTTTT TCCTTTTACA TTTTGATACA TTATTTTAAT TTTAATTTTA AAATTCAAAA GAATTTGCCA CTCATCTTTG CCACTTCAAG GAAAAAAGAA ATGTGTTCGA TTATTCTGTT CTTAGTATAG TTTTGGCAAT TTCCTCACGT GTAAAAAGAG AATACTATTA ATAATTTCAG TATCTATAAG ACAATATAAA ATTAAAGAAT CTAGCCCAGT AACTGGTACA TGGAACGTAA TTAATAAATC ATTATGGACT TTTTTTCTCA CACCCAAGTA GGGAGGAATC AGTGGTCCCC TAGAGGCCCA GTGTAGAGGT GGCAGCACCA ATCCCTAGGG GAGAAGATCT TGGTGATGAT AATTCCTGAG CAGACAGTTA GCTGAGAATT CAAGAGCAGA AAAGTAAGAA AGAAACAACT TCTTGCTAAC ACCTTTCCAC CCACGTTTCC CTGTTCTGTT GTACTCTGCT TACCCTTTCA TGGATGGAGG CAGAGGAAAG AGAACCAAGT TTGCTCTTAG TCATTCACTA TGTTGTTTAA TCTGCCTTCC ATCTTTCTTA TCAGTTCAAA TTAGAATGTA GACCTGAATT TAAATCCCCG TTCTGTCAGT TATAATGTGA CCCTAGACAA AACACATTCT CTGAACCTCA GAGAACATTC TTCATTTGTA GAATGGGAAG ATTAATCTAT ATTCCACTTG GATGGCAAGT CTTTTATAAA CTTTATAACC TAAACATGTG TGAGTTGCTA GTATCATTAT GTTGGTAAAG TTATTCTGAG ATATGATAAC AGAACTGTTT TGTCTAACTC CACTAGCATG GTTCAGGTTT AGAGAGTGTG GAATTAAAAG GCTTTATCCT CAAATATGAC TTAAATCCGA TTTTTCTCAT CCACTTTCCT CCACAAACAA ATCCTCAGGA AATGACAAAC TTTACATGGT TAAACATCAG TTTTGTTTAG TCTTTGACAT CCACATGGTT AAATCATACA TTTGAAAACT GCTTATATTT GTGTTGTCTA TGTCTAAATT GAAAAGACTT ATTGAGGAAT AGAAGACTAC ACATTTTTCA GCAAACACTG CACGTTTTGC AGAATTTCCC CAGGCACCAG TCTCCAGGAA TTTATTGGCT ACTAACAATA CTAAGATATG GATGAATGAG GAAATCAAAA TGGAGATCTT GCAAGTTTTG TGAGAATGGG TGAATGGTCC AAATGAAGAG ATAAGTTGTG AAATATTAGT ACAAGTAAAA ATTATTTACA ATGAAAGACA TTTTGTCAAT AGCTATGAGA ATTTTACCAT TGACCCAGAA ATTCCATTTC TTTCTTCAGA AATACCCACG TAGGTATACA TATAAAAAGT TATTCATTAC AGTATCGTTT TTCATAGGAA AAAGTTTTAA AAATCAGAAG CTATCTAAAC TATGGTATAT CTAGGTCATA GAAATCAAAT GACTAAAAAT GTTAATATAA GCATATGTTT TTAAATTAAC TTGGCTTGGG TCTTCAGCAA AATTGGCTTC TTAACATTGC ACTCCAGAGT EPI-109 64

TAGACTTACC CACTCAGTCA CTTATCATGC AGGAGCAGAC TCCTAATACC ACATATCATA GAGCAGAGTA GGACACAGGT TCTCTGCAGG CAGGCAAATC CCAAAGAGAA GGGAGGAAAG GGCTGAGACA CTGCATGGTC AATTTCTTCT GAACTCTGCA ATGTACGGAG GTGGACAGTG TCCACAAAGA TTGCTCCCCT GGACCCACCA TCATAATAAC ACAACGGCTT TGTTTTGTTT TTGTTTTTGT TTTTTGACAC GGAGTTTTGC TCTTGTTGTC CAGGCTGGAG TGCAATGGTG TGATCTCGAC TCACCACAAC CTCCACTTCC TGGGTTCAAG TGATTCTCCT GCCTCAGCCT CCTGAGTGGA TGGGATTACA GGCATGCACC ACCATGCCCA GCTAATTTTG TATTTTTAGT AGAGACGAGG TTTCTCCACG TTGGCCAGGC TGGTCTCAAA CTCTTAACCT CAGGTGATCC ACCCGTCTTG GCCTCCCAAA GTGCTGCGAT TACAGGTGTG AGCCACCGCG CCCAGCCCAC AATGGCCTTT TGTTTACATC TCTAGTGCAG CACTCATTTC ATGTTCTTTC AAGAAGAATA CATATTTCAT CTTTTTATTT TATACAGCAA TTAGCACAGT GCCTGGCATA AGGAAAATGA TCATTAAAAG CTGGGTGAAA AACCTAATAA AGCTACTGAG GATAGGAACT GCAGACCAGC ATGGAAAGAA AACTATGAGC CAGATATTGA CATCATCCTG AAAGGCAGAA GATTTAGTAT AGGCAAGAAG TATGCTTTTG GAATATAGAA AATCTGGATT ATGATAAGAA AAGAATCATA TTTGTCTTAT CTTACCTACT CACTTCTCAG TTCCACATGT TTCTGAGGCT GTTTGTCCTT ACrTTCTTTT CTGTTTTATC CACTCTTTCT GTTCTTTAGA TTGGATCATT CCTATTGAGC TGACATCAAG TTAACTGACC TTTTATTTTG TCCAAACTGC TGTTAAATGC ATCCAGTGAA TTTTTAACTT TATATAGTAT ATCTTTTAGT CCTAGAATTT CCACATGAGT TTTTTAAGTT TCCATTTCTC TGCTGAGATC TCCTATTTGT TCATTCATTA TGACCATATT TTTCTCTACA TTATTGAGCA TAATTATAAC AGCTCTTCTA AAATTCTTGT CTGCACATTC TAACACCTGA ATTATTCTGG GGTCAGTCTC TGTTACATTG CCTTATTACA AAAACAGTAT AAGTCACATT GCCTTGTTTC TTAATATGCA AAATGATTTT TGATTGCAGA CTAGACATTT TGAATTAAAC ATTATAGAGA TTCTGGATTC TCGAGAGAGT ATTGACTTGT TTTTTCCATC AGGCAGGTAA CTTGACTGGA CTCAAACTCC AAACTCTAGG TCCTCTGTAA TGGGCAACTG CAGTAATCTT TGTTTAGTTC TTTAAGACTT ATTGGCCAGG CACGGGGGCT CATGCCTGCA ATCCCAGCAC TGTGGGAGGC CAAGGTGGGA GGATCACCTG AGGTCAGGAG TTCGAGACCA GCCTGGCCCA CATGGTGAAA CCCTGCCTCT ACTAAAAATA CAAAAATTAG CCGGGTGTGG TGGTGGGCGC CTGTAGTCCC AGCTACTCAG AAGGCTAAGG CAGAAGAATC ACTTGAACCT GGAAGGCAGA GGTTGCAGTG AGCCGAGATT GTGCCACTAT ACTCCAGCCT GGGTGACAAA AGCGAGACTC CCTCTCAAAA AAAAATTTAT TGGCACTGCT TGGCATCTGC TATGAATACA TGAAGTTCAT GGGTCAGCTA TAGATCTGGG CACGTTATAC ACAGAATTTG GGTCTCCCTT TCTCTGGATT TCTCCTTTTC TGGATTTCTT TTCTCATTTT CCAGCAGCTG TGGTTGCCCT AAACTCGGTC CTCTGTTTCT TTACGGCAGT AAGATTTGGG AACTTTTAGG TTTTACCTGC CTCTCAGACA AAATAAAAAA TAATTTTCAT CTTGATGCTA CTCCTTTCTT CCAGATGTAG ACACCTCTCT AATTTCCAGT TGCTTTTTAT TGCTCTCCAG AGTCTAAAGA TTATCATTGT TTTCTGTGGG AGAGTTGGTC TGATAAAAAC TACTCCCCCA AAACTGGAAG CTGGAAGCTT GTAATTATGA ATAGACTTTG AGTAGTATTC TTCTTTGGAA AAGGATTTTA ACTACTCCCT ATGTACTTCT TTATTTCCTG TTTTTCTCAT CCGTAATCTT TTTATTTTCA TACTTCCTAA GTCAGACAAT TTTCCTACTT GAAGATTCAG TGACTGCTAT CAAATGACCC CCATATTACT AAATACAATA TCCCCAACTG CATTTATAAA AAGAAAATTT ACTGTTTATT AGTAAACAAT GTTGTAGAAT AGTAAAATAT TGCTGGGCTT TGGAGCCAGA TAATCAAGGT TAGAATCCCA GATTCTAACT TACTAGCTGG TGTATTAGTC CTTTCTCATG CTGCTAATAA AGACATACCC CAGACTGGGA GACTGGGTAA TTTATGAAGA AAAGAGGTTT AATTGACTCA CAGTTCAGCA TGGCTGGGGA GGCCTTAGGA AACTTACAGT CATGGTGGCA GCAAGGAGAA GTTCCAAGCA AAGAGGGAAA AGCCCCTTAT AAAACCATCT GATCTTATGA GAACTCACTC ACTATCACGA GAACAGCATG AGGGTAACTG CCCTCACGTT TAATTACCTT CCACCAGTTC CCCCCCATGA CACATGGGGA TTATGAAAGC TATAATTCAA GATGAGATTT GGGTGGAGAA ATAGCCAAAC CATATAATTC CACCCCTGGC CCCTCTCAAA TCTCATGTCC TCACATTTCA AAACTCAATC ATGCCCTCCC AACTGTCCCC CAAGGTCTTA ACTCATTCCA GCATTAAGTC AAAAATCCAA GTTCAAAGTC TCATCTGAGA CAAGGCAAGT CCCTTCTGCC TATGAGCCTA TAAAATCAAA AGCATGTTAG TTACTTCCTA GATACAGTGG GGGTACAGGC GTTGGGTAAA TACACTGATT CCAAATGGGA GAAATTGCCA AAACAAAAGA GTTACAGACC CCATGCAAGT CCAAAACCCA ATAGGGCAGT CATTAACATT AAAGTTCCAA AATGATCTCC TTTGACTTCA TGTCTCACAT CCAGGTCACA CTGATGCAAG AGGTGGGCTT CCAATGGCCT TGGGCAGCTC TGCCCCTGTG GCTTTGCAGG GTATAGCCTG CTTCCTGTTT GCTTTTTCAC AGGCTGACAT TGAGTGTCTG TGGCTTTTCC ATGAGTATGG TGCAAGCTGT TGGTGGATTT ACCATTCTGG GGTCTGGGCC AGGTGCAGTG GCTCATGCCT GTAATCCCAG CACTTTGGGA GGCTGAGGTG GGGGATCACA AGGTCAGGAG ATCGAGACCA TCCTGGCTAA CACGGTAAAA CCCAGTCTCT GCTTAAAAAA TACAAAAAAT TAGCCAGGCG TGGTGGTGGG TGCCTGTAGT CCCAGATACT TGGGAGGCTG AGGCAGGAGA ATGGCGTGAA CCCAGGAGGT GGAGCTTGCA GCGAGCTGAG ATTGTGCCAC TGCACTCCAG CCTGGGCGAC AGAGCAAGAC TCCATCAAAA AAAAAAACAA AAAAACCATT CTGGGGTCTG GAGAATGGTA GCCCTTACAG CACCACCAGG CAGTGCCCCA GTGGGGACTC TGTGTGGGGG CTCTGACCCC ACATTTCCCT TCTGCACGGC CCTAGTAGAG GTTCTCCATG AGGGTTCTAC CCCTGCAGCA AACTTCTGCC TGGACATCCA GGCATTTCCA TACATCCTCG GAAATCTAAG CCGCGGAGGT TCCCAAACTT CAATTCTTGA CTCCTGTGCA CCCACAGGCT CAATACCACA TGTAAGCCAC CAATGCTTGG TCAGGGCTTG AACCCTCTGA AGCAATGGCC TGAGCTGTAC GTTGACACCT TTTAGCCTAG ACATCTAGGA CACAGGGCAC CATGACCCGA AGCTTCATAA AGTGGGAGGG CCTTGGGACT AGCTGAGGAA ACCATTTTTC CATCCTAGGC CTCCAGGCCT GTGATGGGAA GGGCAGCCAT GAAGGTGCCT GACATGCCCT GGAGACGTTT TCCCCATTGT CTTGGTAACT AACATTCAGC TCCGTGTGCA GCACCAACTT ACTTATGCAA ATTTCTGTCA CTGGTTTGAA TTTCTCCCCA GAAAACAGGA TTTTTCTTTT CTATTGCATC ATCATGCTGC AAATTTTCAA ACTTTTATGC TATGCTTCCT GTTGAAGACT TTGCGGCTTA GAAATTTCTT CCCCCAGATA CCCAAAATTA TCTCTCTCAA GTTCAAAGTT CCACAGATAT CTAGGGGACA AAATGTTGCC AGTCTCTTTG CATAGCAAGA GTGACCTTTA CTCCAGTTCC CAACAAGTTT CTCATCTCCA TATGAGACCA TCTCAGCTTG GACTTAGTTG TCCATGTTAC TATCAACATT TTGGTCAAAG CCATTCAACA AGTCTCTATG AAGTTTCAAA CTTCCCCATG TTTTCCTGTC TTCTAATAGC CCTCCAAATT TTTCCAACCT CTGTCTGTTA CCCAGTTCTA AAGTCACTTC TACATTTTTG GGTATCTTTA CAGCAGTGGC ACTCCCCATG GTACTAATTT ACTGTATTAG TCTGTTCTCA TGCTGCTAAT AAAGACTTAC TCGAGACTGG GTAATTTATA AAGAACAGAG GTTCAACTGG CTCACAGTTC AGCATGGCTG GGAGGCCTCA GGAAACTTAC AAACATGGTG GCAGCAAAGA GAAGTTCCAA GCAAAGAGGG AAAAGCCCCT TATAAAACCA TCAGATCTTG TGAGAATTCA CTATCATGAA AATAGCATGA GGGTAACTGC CCCCATGATT AATTTACCTC CCACAGGGTC CCTCCCATGA CAGGTGGGGA TTATGGGAAC TACAATTCAA GATGAGATTT GGGTGGGGAC ACAGCCATAC CATGCCAGCT AGAGAGCCTT AAGAAAGTCA CCTAATCTCC ACAAATAAAA GGTTTCCTAT TTGTTCAACA AAAATAATGA CACCCCTTTT ATGGGATTTC TGTGAGGACA AATGATAACT AACATAGCCT TGCATAGTGT CTGGCACAAA ATAGCTACTC AAAAAATAAT AGAAACAACA TTTAAAAAAT GTAGACTTTA TTTTTTAGAG TTTTATGTAC AAAGCAAAAT TGAGCAGAAT GTACAGAGAG TTTCCGTATA GCACTCCCTA CCCCCAAGCA CAGATAGCCT CCCCCAGTAT CAGCATCCCG CACCAGAGTG GTACATTTAT TATAACTGAT GAATCTATAT TGACGTGTCA TTTTCATCCA AAATCCATAG TTTATATTAG GGATGCCTCT TGGTGTTGTA CCTTCTATGG GTTTTGACAA ATGTATAATG ACATGTATTC ACCATTACAG TATCATAAAG AATAGTTTCA CTGTCCTAAA AATCTTTGAT CTTCTTCCTA TTCATCACTC EPI-109 65

CCTCCCCATT AATCCCTGAC AACTACTGCT AATTTTCCTG TCTCCATTGT TTTGTCTTTT CCTGAATGTC ATATAGTTTA AATATACAGT ATGTAGGATT TTCAAACTGG TTTATTTCAC TTAGTAATAT GCATTTGATG TTCTTCCATA TCTTTTCAAA GCTTCATAGT TCAATATTTA TAGAATTGAA TAATATTCCA TTGTCTGGAT GTACTACAGT TTATGTATTC ATTCACCTAT CAAAGAACAC CTTGGTTGCT TCCAAGTTTC AACAATCATG AGTAAAGCTG CTATAAACAT CTATGTACAT GTITTITIGT GAATTGAACA TTTTCAGCTT TTTTAGCTCC ATTCCTAGGA GTGCAATTGC TGGATTGTAT GATAAGGGTA TGTTTAGTGT TGTAAGAAAC TGCCACGCTC TTCCTAACTG GATGTACTGT TTTGCATTCT CACCAGCAAT GAAAGAGTTC CTGTTGCTCC ACATACTCAC CAGCATTTGG TGTCGTCAAT GTTTTGAGCA ATAGCATTTT GATCTAACTT TTCCTAGGTA TTCTTTTTGA AGGAAATAAT ATGACAGATA ATAGAGAAAG GATATACGAG GACAGTTCTG TCCTTTATTT ATAGTCCATC ATTTAATGAA GGACTCTGTC CACACTTGGT ATTTTTAACT CTGATCCTCC TCTCCCATGA ACTCTGACAA TCTCCTAAAT CCCTGTTGCT GGCACACATG GTTGTGTATC AGGCCCCCTG TGGTCTGTCT GAAGCATGGC TTTTTTTTTT TTTTTTTTTT TTTTTTTGAG ACGGAGTCTC GCTCTGTCGC CCAGGCTGGA GTGCAGTGGC GCGATCTCGG CTCACTGCAA GCTCCGCCTC CCGGGTTCAC GCCATTCTCC TGCCTCAGCC TCCCGAGTAG CTGGGACTAC AGGCGCCCGC CACCACGCCT GGCTAATTTT TTGTATTTTT AGTAGAGGCG GGGTTTCACT GTGTTAGCCA GGATGGTCTC GATCTCCTGA CCTTGTGATC CGCCCGCCTC TGCCTCCCAA AGTGCTGGGA TTACAGGCGT GAGCCACCGC GCCCGGCCTT TTπTTTTTT TTTTTTTTTT TTTGAGATGG AGTCTGTCAC TCTGTCACCC AGGCTGGTGC AGTGATGCAA TCTTGGCTCA CTACAACCTC CATCTTTCAG GTTCAAGTGA TTCTGCCACC TCAGCCTCCC AAGTACCTGG GATTACAGGT GCCCGCCACC ACACCCAGCT ATTTTTTTGT ATTTTTAGTA GAGACGTAGT TTCACCATGT TGGCCAGGCT GGTCTCATTC CTGACCTTGA GTGATCCACC TGCCTTGGCC TCCCAAAGTG CTGGGATTAC AGGCATGGGT CATCACATGT GGCCTGAAGC ATGACTGTTG CTTTAATCAT ATGAAATACT GCTCTGTATT GTTATCTATT TGAAATGCCA CACCTCCTGA GCTAAATTGC AAGCTTTTAT GGAGCACAAA CCATATTTAT ATATATTAGC ATGATACCAT GACACATATC AAAAGCTGTT ATATATTGTT ACGTGAATTG ATTCTTTCTC AGTTAAGAGG ACCTCTGTAG TAGCACTTTC ATACCGTTAA TTTTTCATTT TGTGCCCAGC CCCTACTCTG TGAAAAATGA AATGAATCCT GTTATCATTT CCCTCCCAGG CCTTTTCTCC TTGTGGACAA TGTGTGGCTC AAGAGAAAAT TCAGTCAGTA AATTTGTTCA GTGCACAAAC TCTTTATCAC CTCTCACTGT TCTCAAGTGA GATAGAACAG AACATCCATC CAGTGTCTTA CAAATTGTCT GGTATATAGT AGGCACTCAA TAAATGTTTT TTGAATAAAT GCATACATGA ATCCTATTCC TATATATAGT ATGGTAGACA GATCATTGAT ACCCAAAGAT GCCCAAATGC TGATCCCCAG AACTTGTGAA TATGTTACAT TTCATGTCAA AAGGGACTTT GCTAATGTGA TTAAGGATTC AGACCCTTGG ATTGTAAGAT TATCCCGGAT TAACCAGGGC CAATCTAATC ACATGAGACC TTAAAAAAGC AGAAAACATT TCCCAGCTGG GTTAGAGAGA GATGAGACAG AGTAAAAAGG AAAGAGATTC AGGGCATGAA AATGACTCTA CCCACTGTTG CTGGCTTTGA AGATAGAGGA ACTAGGCCAC AAAACAAGGA GTATGAGTGG CCTTAAGAAA TAGGAAAAAG CCCTCATCTG ACAGCCAGCT AGAAAGCAGT CCTCTGACCA CAAGAAATTG GATTCTGCCA ACCACTCAAA TGAGCAAGGA AATGGATTCT CCCCTAGAAC CTCCAGAAAG GAACACAGCT CTGTAATGCC TTGATTTTAG CCAGGTGAGA CCTGTTTCAG ACTTTTGACC TATGGAAATA TAAGATAATA AAGTTTTATT GTATGCTGCT AAATTTGCGG TAGTTTATTA CTGAAGCAAT GGAAAGCCAA TACAGACAGA ATATACAGAG AGAAAGAGAA TGAGTTCTTT CCTGATAATT TGTAAATATT TGGGTCTTCA CTGGACAAGC TTCACAGAGG ATTCACTGGT TCCCTAGCAA ACCAGCATGT CCAGTCCTGC AGCCTCCCTT TCTTAGGCCC AGCATATGTC AGCTGTGTGC ATAGAAAAAT CAAAGCAGGA CCCTGAGTAG TTGGAAAGAA AAGATGGTTG GAAATGGGTT GCACTTCAAG TGAGGAAACA AGAGGTAGGA GACCGGCATC TCTTTCTCAT ATGTCCCAGG CTGACTCTTG TGAGTTGTTT TCCCTTGGAG GCTATCGATG ACAGTCACAG TAACCTGATG GAACCTGGAT CATGATGAAA GAAGTAAGTG TCAATGGCTC CGACTTCCAA GGACTCTGAT GTCCCACAGC ACTAGCTAAA CAAAGCCAGT TGGAAATGAG CTTAAATGGG GAATTTCCTG AATATATTCC CTATTGTTAG GAAGCCAGGT TGGCTTCCTT GCCTACAATT ATGCCAAGCA GTCACACTAT AGAGTCCCTA GGGACATGAT ATTAAGTGAT TCTTTTAACA CAAACAACTT AATAATCATT TATACTAATA GCAAAACGGC CAACGGCTGA TATTCCACTT GAAGTAGAAT TGGCTATCCA ACTGGAAGAG AAGACAGGAA GACGTGATCT CCAGGGAGCC ACTAAAAGGA TTGGCACCTG CCTCTGGATT CCCCTTTTCC TTATATTACC TCTCAGCACT GGCAGGCCTT TATTTCAGGA TACAGTTTCA CAAGTATTAT GTCACGTCTC TGAGAATTAT GTTGGTAGAT ATTTGCTCCT CTGGCCAGAA AGACCTAGTT TGGAGTCTGG AGTCATGAAG GTGACATACA TGTAGCTAGT GACATAAGTG TAGCTAGTAA AAATAGTGAG TAATGGCCCT GAAATTCTAT TGAATGCCCA AAGTGCTGAC CAGGAACAAG CATGCTCTAG CTTATCTCAC AAGGAACTTG ACAATTTTCT TCAAAAATCC TAGTAGCTAA GATTTCTTAG TAACAAAGCC ACTAAGGCAC AATTATGATT AACTTGACCC TTAGGTGACT TTTAAGGACT ATTCTATAAA ATATTACAAC TAATAGTGGA TCCAAGCCAG CACACTCTGC TATATAAGAT TAATTGACAG TGTCCACACT GGTAAAATAA GTTGTTTCAT AAATACATTA GAATTCATTT GCACTTTCTA CACAGCCCCA AGTCCAGAAC TTTCCCCAGA ATAGGTCTAT GTTTTGCAAT CTGCTACTCC ATACAGAGAT TTGAGTTCAC TTGGCAATTT AGTGCTGCTT ATATGTGACC AGTTAGTCTG TTTTACTTAT CTATGCCTTA AACATTACTA TACTTACTAA CTCCAAGATG CCTGGTCTCA ACTTGACAAA AATACCCCAA GTTGGGAAAT CCTTATGTGA ATATGTAGAT AGTCACAATT GCTGGTTGAT GATGATCTGT CTTTTCCTGT ATTTGAGAAA ATGGAGATAA AATGGACCAA TCCAAATAAT GGATTAAACA TGGGAATAGG TGAGAGAGAG AGAGGAATAC ATGGTGGCTC TCAGTGTCTG GCTTAGGCAG TAAACACTTT CGTTAATAAA GACGGAAAAT AAAAAAGGAA TAATTGGTGT CTAGGGGAAA ATAATGAGCT CAAGTTTTAA CACTCTGAGT TCCCGGATGT GAGACATCCA GGCGCATTTA TCCAAGAGGC AGTTGGAAGC AACGTTCCGG AGCTTAGGAG AGAGGCATGA CCAAAAGCTG GTGGGACTGT GAAAAGGTAT GGCCATTCTG GAAAACTGTT TGGCAGTTTC TTAGAAAATT AAACATGTAC TAACAACCCA GCAATTGTAC TCTTGAGCAT TTGTCCCAGA TAAATGAAAA AAAAAAAAAG CATTTTTTTT ACACAAAAAC ATATACATGA AAGTTCATAG AAGTGTTATT CATAAAAAAC TGGAAAAAAC TGAGATGTCT TTATTGAGTG AATGCTTAGG CAAACGGTGG TCTATCCATA CAATGGAATT ATGCTTAGCA ATAAAGAGAA AAGAACTATT GATACATGCA ATAACACAGA TGAATCTCAA AGGAATTAAT GCTGAGTGGG AAAAAAAGCA CATCTCAAAA TGGTATATAC TGTACTATTT TATTTACTTA ACATTTTAAA AATAGCAAAA TCATAGAGAT GGAGAACAGA TTAATGGGTA CTGTGTTTTG GGATGGGGAG TGAGAAAAGG GTAAGGTGTA AATATAAAGG GGTAGCACAA AAGAGCCTTG TGGTTGAAGG ATTCTATGTC TTGGTTGTAG TCGTGATTGC AGGAATCTAC ATGTGATAAA ATTGTATGGG TCTACATACG CATACACACA AGAGCATATA AAACTGGTGA CATGTGAAGA AGCTCCGCAC ATTGTGCCAA CATCAGTATC CTAGTTTCAA TATCAGACTA CAGTTATACA AAACATTGTC ATTGAGGGAA ACTGGGTAAA GGGAACACAG GACATTTGGC ATATATTTTT GCAATTTCCT GTGAATCCGT AATTATTTAA AAATAACAGA TATACTACAT ATCAAAAATT TAATGTCATA AAGTTGATGA GTTTACCTAG TGGATAGCTT TGTTAATATC TGCTATAAGA CTACTGAAAA TGACAGTTAT GCAAGTATAA GCTCAGAGAA CTTTCCTCCC CCTTCGTAAA TGAAATGAGC AAAAGAAATG AAACAGGAAA GGCAAGCAGT ACTGAAAACA GGGAAGGGCT CTTCCCCATA TAACTATATC TGCGACTTCA ACAGCTATTC ATCCAGAAAC ACAGCCTCTT GCGCTAAGAG GAAACTTTGG ATAACAATAT GTTTTCACTC TCCAAGAGAG AAAATGGATA GATTAATTTT TAAGAAAAAA AAAAAAACCT CACCAATTTC ATGCTGTGGC TTGCACCTTT AATCCCAGCT ACCTACAAGG CTGAGGTGAG AGGCTTACTT GAGCCCAGGA GTTCAAGGCT GCAATGAGCT EPI-109 66

ATGATTGATT GTGCTATCGC ACTCCAACCT GGAGTACTAA GCTAAGAGCT AAGAACACAG CTGAGAGCGG AGAAGAAACA AACAAATCTG ACCAATAACC CCCACTCCCC TCATTTTACT GGAGTGAGCT GAGACTGCTG GCAAACATGG CCTTTGACCT AGCCTGAACT GTAGCAAAAG TCATCAGATA TTTTTCCACC AATCAACAGA CAGAAGTGGG GAGAAAACAA TCGTAGTTCA TAACTACAAC AAGCAGATAA ACGAAGGCCA TGGTGAGGGA TGGAAGACAT TGTGATATAT CAAAGGCAGG CTCATTTAAA ACTCAACCCA AATTCCAAAC AAAATATATA ATTGAATATG TATTAATGCC AAAGGAGCTT GAGTGAGCTT TAGCACAAAC CCCGCCCTCC AGCCCCCACC CAAAAAAATC ACTCTGTTCT CTCCCCATTC TTTGATAGGC ATACTTGCTG TTTTCTCACA GCCAAGGTAC AGAGGGGACT TAGAGGAACT AGAACTCTAA TACACTGCTA GCAGGAATGT AAAATGAAGC ATCTACTTCA GAAAACCATT TTATCAGTTT CTAGAAAGTT AAACATAGAC CCACCATGCA GCCCAGCCAC TCTACTCCTA AGTATTTACA CAAGAGAAAT GAAAACGTGT CCCCACACAG TTGTATTTAA AGGTGATGGT TAGCCTTGTG TGTCAACTTG GCTAGGCTAT AATACCCAGT TACTGAATCA AATAGTAATC TAGGTGCATC TGTGAAGGTA TTTTGTAGAT GTGGTTAACA GCTACAATCT GTTGACTTCA AGTAAAGGAG ATTGCTCTTG ATAGTATGGG TGGGCTTCAT CCAATCAATT GAAGGCCTTA AGAGCAAAAA GTAAGGTTTC CCGGAGAGAA AGAAATTCTG CCTCAAGACT GCAGCCTCAA CTCCTGCCTG AGTTTCCAGT CAGCCAGCCΛ GCCTAAAGAT TTGCTAGGCA TTATAATCAC ATCAGCTAAT TTCTTAAAAT AAACCTCTTT ATATATATTG ATACAATGAA TGGTTATAGC AGCCTTATTT GTAATAGCCA CAAACTGGAA ACAACCTAAA TGTCCTTCAA TAAGTGAATA CATAAACAAA TTGTGGTATA TCCACAATTT TTACGCAGCA GTAAAAAGGA ATAAATGGTT GAATAAGGAA TAAACACATA ACAAGGATGA ACCTTAAAAC CGTAAGGCTG AATGGAAAAA GTCAGACAAA ACTAATACAT ACTGAATAAT TCCATTTATA TTGAAGTTCT AGAAAATGAG GACTAACCTA TAGTAACAAA AAGCAGAAAA ATTTTGCCCA CTGGTGATGG AGGGGGCGCA GGTATTGTAG AGTATCTGAG AAAGGACAAC TGGATAAAAG GGGGCACAAG AAAACTTTTG AGGGTGATTG ATATGTTCAT TATCTTGTGG CATGGTTTCA TAGGTGCATA CATATGTCAA AACATCAAGT TATACACTTT TAAAATGTTC AGTTTACTGT ATATCTATTA TACTTCAGTA GAGAGGAAGG AAGAAAGTGG GCAGGGTGGG GGAGAGGAAA GGAAACGAGG GAGGAAAGGC CCTAATAGGA AGGATTTTGG AGTTTAGATT TTAAAATGAT AAAGGATGTT TGACACTCTA GGCATATGAC GAATATAGGA TTATGAGTCC ACAAAAACCA CCAGGAAGTC ATGTATGTTT ATACTTTTAA GTGAAGGATC AGTGGATTAT CAACTCCCTA ATGCTTTGCC TCTCTATGAC TGGCTGCTGT CCTTCTCATC CCAATACTCC TTCCAAAGCC CCTTGCTTAA ATGTAAGCCT TCTTTCCTCC TTTCAACACA TCCTGCATTC CGTGACAAAA TAAGTTTTCC TTAAACAGAA TGTACAGCAT ATTATTTGTA CAATTAAAAA TTTTTGGCCA GGTGTGATGA CTCATGCCTG TAATCCCAGC AATTTGGGAG GCCGAGATGT GTGGATTACC TGAGGTCAGG AGTTCGAGAC CAGCCTGGCC AACATGGTGA AACCCTGTCT CTACTAAAAA TACAAAAATT AGCTGAGTGT AGTGTGGCAG GTACCTGTAA TCCCAGCTAC TCAGGAAGCT GAGGCAGGAG AATCGCTTGA ACCTGGGAGG TGGAGGTTGC TGTGAGCAGA GATCAGACTA TTGCATTCTA GGCTAGGAGA CAGAGTGAGA CTCGGTCCCC AAAAAAAAAC ACATTTTTTT TTAATGTTTC CTCCTTGCCT GTAGGAAAAA GGCTCTGACT CCTTAGCCTG GGCATCAGAG CTCTATCTAA ATGGACTTTA ACCTGATTTT GTGGCACTAA TTCCATTGCA GTACTTGTCC GCTCACTGGC CTGTGCCTCT CTGCCACTAT TTTTGGAATA ATGTCCTCTC TCCATCTTGT TTACTCAACT ATATCCAACC TCTAAGGCTG TGCTCCTACA AAGCCTCCCC TGGCTACTTC AGCCCACAGA GATATTTAAC TGCTCTGCAG TTCAGGACAT TCTTCTGACT CTTTAAATCA CATTTACTTA TATATGATCT TGTGATATTT TTTGTTGACG TGTTTACTTT AATTTTCTTC CATAACCTAT TCATTCAACA AACTCAACAA TTATTTATTA AATGCCAAGT TAGAAAAATA TTATTGATTT TATATAGATT ATAGATATGT TTGAAATTTT ATTTGGCAAT CTGCAAGTAG AAAAATAATT ATAATGTGGT ATATCTGTGA TAGAAGTATT AGTGCAGAGA CCATGGGGAA CATAATCCAG CCTGGAAGTT CAGGAGAGAT ACGTGGAAGA AAGGACGTCA GAGCCTTTTT CCTACAGGCA TGGAAGAAAC ATTAAAAAAA ATTTTTTTTT TTGAGATGGA GTCTCACTCT GTCTCCCAGC CTAGACTGTG GTGGTGCGAT CTCTGCTCAC TGCAACCTCT GTCTCCCGGG TTCAAGTGAT TCTCCTGCCT CAGCTTCCCA AGTAGCTGGG ATTACAGGTA CCTGCCACAC ATGGATGATA AATATGATCA TATTTTCTTG TTCTTTTCCT CCTCAGTTGT CTTCCCTGAA GAAAGGAATG CCTTTTATAG ATGACAAACT CCCATTCTCA AGAACAAGGA TTTTTGACCA ATTTAATTTA ATCAGATGTC TGGCTTTGAC CTAGAAACAC AGTCACGAAA CTTGGTGATT AGAGACCAAT TCCCAAACAT GAGCATTTCT TAGGAAACAC AGTAAAGATC TGAGAGACCC AAGAGCAGAA GGGCGAGAAA CCAAAAGCCA TCAGTTTGCA TAGGAAACAC CTTGTTTAGC CTAATCTTTT TATTTTTATT ACTCTATTAG TCACTACAAC TATTTTCTGA TTGCTATGGT GATAGATGGT TTAAAACAAG CCTTCATTAA GAATTGTCAC ACCATGGTCT CAGTCAAAAA CACCAACATT TTTATTGGTA TTGACAATTA TGGGAATATC CAATTCCAAG AAGACAAGGA GACCTCTGAA CTTTCTAAAT GAAGACTCCA ATCTTCCTGA TCTGATGGGA AGCAGCTTGG CAAGATTACC AACCACCACC ACAGAGAGTG GACTCTAAGC TAAGACTTAA AAGATAAGTA GAAATTATCC AGGTAAAGAT GTGTACAGAG AAGGAAGTAC ATCCAGGGGA AAAGAACAAT ACGTGCAAAA GTACGGAAAT GGTAAAAAGT AATACTACAT AGTCAAAGCC AAGCAGAGTT CAGAAGGGAT CTGGTGGTGA AAAATACGGC TAGAGAAAGC AGCAAGGATT GGCTTCTAAA ACCTATGTAG TATCTTGGAC CTTACCCTAA ATGTAATGAG AAGCTTCTAA AGAATCTTTC ATTTATTCAT TCATTGAACA AATATTTTGA GGCTTTCTGT GAAGAACATC ATTCTAAGTA GTAAAGATAC AGCAGTGAAT AGGACACATA AAATCCTAGA TCTCACAGAA TTGACATTCC AGAGAGGGAA AGGTAGACAA TAAATACATA AACAAATCAT TTAACAAGAT GATTTCAGAC AATGGTACGT ACTGTGAAAA AAATGAAACA AGGTAATGGA CAGCGAAAAG GCACTGGAAG GAAGCCTGCT TACCTTTGCA TGGTTAGAAA AGATCTCTCT AAGAAAGAGA CCACATGTGA GCTGCGACCT GAAGGATACC GAGAAGCTAG GTGTGCAAAG ATGTGGGGAC AGAACTTTTG GACTGAATAG CAAATACAAA TGCCCTTGGG TGCAAGCTTT GCCTGTTCAA GGACCAAAAA GAAGGCCAGT GTGCCTGCAG CATACTAAGC ACAGAGGAAA ACACTGTTAT ATGCTGAGAT TGGAATTATA AGTAGAGCCA GATAATATAG TCTCTTATAG GTCATAATAA GGCAACCAGA TTTTATTCCA AGAGGATTTA AAAATCACTG GAGGTTTTGC ACTAGGGTGA GAGGTGTGAT TTGTATTTTT AAAAGATAAT TCTGGAGAAT TAACTATAAT GAGGTAGGAG TAAACTAAGT TAGGGGCTAT TTCAGTGGCT CAGACAAGAG ATAATGGTAG CTTAGACTAG GATAGTAGTC GTAGAAATAA ATAAAAGTGG CACTCTACTT TGGGGGTAGA GTCTATAATA GGTTTGGTTT ATGGATCATA TATGAGAGTA AAAAAAAGAA AATAAATTAA TAATGGTTCC TAGGTTTGTA CCTGAGCAAC TGAATAAATG GGTGCTGTGA ATTGAGATAA AGGAGATTGA GAATCACAGG CTTTGTTTTG CAAATTAATT TTGAGAGGCT TATTAGACAT CCCAGTGGAG ATTTCAGGTG AGTGGAGCCC ATTGAAAGGT AAGGGACAGG GTCAGGTGTG GTAGGTCAGG CCTGTGATCC CAGGACTTTG GAAGGCCAAG GCAGACAGAT CAGTTGAGCT CAGGAGTTTG AGACCAGCCT GGGCAACATG GGAAAACCCT GTCTCTACAA AATATGCAAA ATATTACCTG GGCATGGTGG CATATGACTG TGGTCCAAGC CACTTGGGGG GCTGAGATGG GAGGATCACT TGAGTACAGG AGGCGGAGGT TGCAGTGAGC CAAGATCTCG CCACTGCAAA CCAGCTTAGG TGACAGAGTG AGAACCTGTC TCAATAAATA AATAAGAAAC GTAAGGGAAA AGGAAATTAA TCTGATCATT GGCAAATGCA TAGTATTTAA AGCCAGGGGA GTAGATGAGA TACTCAAAGT AGGTGAAGAT AAGGAGGCAA TGAAGGCCTA GGACTCTGGT GTACATTTAG ATGGTTATAA GAGGAATAGA AACTGGCAAA ATAAGTAACA CTGAGCACCC AATGAGGTGG AGAGGAAAGC CAGGAGATGA AGCATCATAG AAGGCAAGAG AAGAAGGGTG TCAAAGAGGC GAGGCAGTCA TCAACTTCTG GGCAGTCAAA TAATATAAGG ACAGAAAAGT GACCATTGGA TTTGGAAATA TGATGAGCAC TTTGAGTGGA GTGTTGAGAC AGAAGACCAA TTAGAGTAGA b l-109 67

TTGAGGAGAT AACGAGAAAT GAGAAAATGT AACCTGCAAG CACAGACAAT TCTTGAGAGA CTTTTCTGTG AAAGGAAACA GACACAGAGT CTTAGCATGT CTTGTCTTTC TATGGGAAAT GTAAATAGTT TGAGATCAGG GATAGTATTT TATTCTGCTT TTTGTACCTC TACATTACCT AGCATAGAGC TAGCTAATGT GCACTTAAGT ATGTTCTCAA TTCTTATCGC CTGAATGACT GGATGGGTGA AAGAATGGAT GGATGGATGG ATGGATGGAT GGAAGGATGG ATGGATGGAT GGAAGACTTC TGATTTGCCA AGAAGAGGAT ACTGGTAGCA GAAATAAAAA CAGCACTGGA GAAAGAAGAG TTTAGATTTT TATTCTTTGG TGTCAGTTAG ACAGGAAAGT AAGACATTAG AAGAGTCCTT AGATAATTTA TGTAATTGTT CACTTAGGAT TTTTAAATGT GATCACTGAT ATTGGACATG TTCCTAGTGA AGCATTTTTG GTGTTTCACT GGTTGAAGTT AATAACTGTA AAATTATTTC CCGTTCAGGA CAGAAAAACA GAAAACTTGA AGCTCCTATT AGAAAGTTCA AGATTCTCTG GGGTTCTTAG GATTTACTGT TCCCAAAACT CTGTCAAGAA CAAGAAAATG ACCTGTATAC TTAACTGGTC TAGGCAACAG TGGAAAGACA ATTCTCAGAG AAGATTTGTT TTAAGAAGAC ACTTTCCATA GGAATCAAAC AATAGCTTTC AGTGACTAAC ATGGTAAGAC ACAGGGTGTT AGCTCTTTCC TTCCAACCTC ATGGCTGTTG TACCTTACCT TTCGACCCCG TGTTCCTGAA ATTGTTAAAT TCATAAACTT ACCAAGGACT AACCAGCCTC TGGGGAATTG CTGTATACTT AGCAAACTTA CAATGGACAT ATTTATAAGC CATAATGATA ACTGACTAAT AGGAAATACC CTCAACTGAA AATGAGAGAT CATCATTTGC AAATGAGTTC CCTTGCCCAG GCAACTACTG GGGAAAATGT CATGCAAGCA AAATTAATCT TTGAAATCCT CCTTTTCCAT TTTTTGTGTC TTCCTTTTCC ATAGGCACCA GAAATATCAT GGTGCCTGGA TCTCATCTCT ACAGAAAAAA AAAGTGATTT GATAAACTGA TTTATATTGT GTCCAAATGT GATTGTATTT TCAAAGATAA CCTAAGGGGA GAATGCTGTC TGGCCCAACA GCAGGCTCTC GACTTCATTT CAGACACTGT GGCCAATGGC TGGGAAACAG GTATGAACAG TAGGTTTCTG AGTCCCCTGG AATTATTCCA TTTATGTAGC CACCTCCATG ACAGGAAGCC TCCCTACTCT TACTTCCCAG TTTGTTCATT CATGGCACCA GGTTGCAGAT TAAAATTTGC TCAGTGACCT TTTATCTAAT AATGTGTTAC CTTCTTCTCT TAAAAAGTAC AAGGGACAAA TGCTCATGGT ATACTTTTAG GAGATTGTGG CTCTCTATTA ACAGTATTTA TTCAACAAAC ATTTATTGAG CATTTATATG TGCATCATGC TAGGGACTGG AACCTAGTAA GTGTAGCACA TATTATTTCA TTTAATCCTC ACAACAAACC CATGAGGTTG GTTTTATGAT CCCAATTTTT CAGAAGAAGA AACTGATATT CAGAACCAGT TAACTAACTG GTTCAAGGTC ATGCAATTTC TAAGATACAG AACCAAGAGT CAAAGACATG ATTTTAAACC AAAGCTTTTT CTGCTACTCC ACATTGCTTC CCTAGGTGAG ATCTGAGGCA TTCCGCGAAA AGAGAAGGGT CATAAAGCCA AGGGAAGACA AGCTTAGGAA AAAAAAGGGA AATGTCCTAA ATAAACAGCT TTCCTATTTA CCAGAAACCA CTAGTTTAAA AATATAATGG GAAAAATCCT ATTCACTTTA ACAATGTTAA AAAAAAAAAA GATAGAAGAA ACATAGGGAT AAACTTAACA CATTTGTAGG ATATGTAAAG AAACTAAAAG ATGTTAATAA TGGCCTAAAG AAAAAAAAAC TTACATGTAT GGGGAGATAG ACCATCTTAC TGGATTCTAA TATTTAATAG TCTAGGTGTT CCATTTCTCA CCAAATTAAT GTATACATTT AATACAATGT CAAACGAAAT ATCTTAGGAA TTGCTTACAA ATTGTCAGAT AATTACAAAG TTTACCTGGG AAATATAAGC ATATATGAAG AGTGAATGGG ACCCCACCAC TCCCCCCAAA ACAAAAAAGG TCTGAAAAGG ACAGAAATCA AGGAGAGTCT TGCCTGCCAG ATACAAAATT CTATTATAAA GGTGTATTGA TGAAAACAAT TTAATACTAG TGTAGCAATA GGCAGCAAAG CAATGAAACA GCATAAAAAG ACCAGAACTA TACCTAATTA TGATGAAGAT TTAAGGTATG ATAAACATGA CATAATTCAA ATCAGCAGAA ATTGGCATAG ATAGGGTTAA GACAAATAGC TAATCATTAG AGGGGAGGAA GGAAAGGAGG GAGGATAAAA TTAGGTTCCT GCCTTCATCT TACATTAAAA TAAATTCCAG ATGTATTACA TTTAAATTTT TTTAAAAAAA GAAACCACAA AATACTTGAA GAAAATATAA GTTGTTATAT AGTCTTTTGA TGGGAATTTT TTTTTTTTTC AGAGACAGGG TCTTGCTCTG TCACCTAGCC TAGAGTGCAA TGGCATGATC ATGGCTCACT GCAGCCTTGA ACTCCTGGGC TCAAGTGATC CTCCCAGCTC AGCCCCCCAG GTAGCAGGAA CTACAGGCAT GCGACACCCC ATCCAACTTA TTTTTTATTT TTTGTAGAGA CAGGGGTCTT GCTTTGTTTC CCAGGCTTAT CTCGAACTTC TGCCTTCAAG CACCTCAGCC TCCCAAAGAG CTGGGCTGAT GGGACATTTT TTAACATAGT GCCACATTAC CATAAATGAA AAGCTTGTAA AATACTAATT TTTAAAACTA ATATATATCA GAAATTTTTA TAAACAAAGT TAAAAAGCAA ACACAAAAAA TTTGTAGCAC TTATGACAAA TATATGTATA TATATGAATA CAAAAAGAGC CTTTACAAAA CAGTAAGAAA ACAATGAATA CTCCCAATGG AGTATTCAAA ACTAAACTGC TAAAAGCAAT TCAAAACAAA AAACATAAAC TATGCATATA TGTATGTGAA AAAGTTTAAC CTTATCAAAG AAGTAAACTC TCAAAGAAAT AAACATCAAA TAAGGAAATA GCCTTTTCCC ACAAATAACC AAAATCTGTA AGAATACTGA GCTGCGAATG TTTCAGAAAA AAAAAAAAAT CATACACCTA GTTCGGCATG TAATTAATAT AGATCAGAAC ACTTTAAAAA TATTTATAGG CCAGGCACGG TGGCTCATGC CTATAATCCC AGCACTTTGG GAGGCCAAGG CGGGTGGATC ACCTGAAGTC AGGAGTTTGA GACCATCCTG ACCAACATGG TGAAACCCTG TCTCTACTAA AAATACAAAA ACTAGCCAGG CATGTTGGCG TATGCTGGTA ATCCTGGCTA CTCGGGAGGC TGAGGCAGGA GAATTGCTTG AACCCAGGAG GTGGAGGTTG CAGTGAGCTG ACATTGTGCC ACTGTACTCC AGCCTGGGCA ACAAGAGCAA AACTCTGTCT CAAAAAATAA TAATAAATAA AAATAAAATA TTTATATACT CTGACCCATC AATTTGTCCA GCATAATTAG GCATGTGTAC AAGGGTTTAC ACACAAGAAT GCCTATTGCA ATATTGCTTT TAATGCTAAA AAAAATTGGG GAAAATGCTT TAAAAATATA GATTAAGACT GTACATTGTG GTACAGTCAT ATAATCAATA GTATACAGCT ATTATTTATT TTCAGCCACT GTCCAAAATA TAGCCTGGCC TAACAACATT CTGTTAGGAT ACGCAAGCAC CGTGAGGAGA TCAGCTATAA AGTATCAGTG TTTCACACCA CTGCTCCTTT GCTAATAACC TTCAATGGCT TTTAAAGAAG TAAAAAACAA AGGCAAAATT CCTTAGTCAG CCCTTAAGAC TCTCTGTTAC TTAGCTCAAA CTACCCTTTT CAACAACACT GCCCTAACCA GGATGAGTTT TTTGCCCCCC TGGAGTACAT TCAGCCTTTC CTTATCAAAC CTTCCTTTAA ATAAGTATCT TCTCCAGGAC CACTTCACTT TCTTCCCCAA TTTAGCATTT TCTATATCTC CAGGCCTACC TCTATAAAGC CTGTCCTAAC CACTCAAACC CTAGCTTTTT CTCTGAACTG CTAGAAATAT TTTTCTCTCA TTGGCCATTT AGGTAAAAAG GTTTTTACTG TTTATTACCT ACTCAATAAA AATTTTCTTT TTTTGAGACA AGGTCTTACT CTGTCGCCTA GAATGGGGGG AAGTGGTGTG ATCACAACTC ACTGCAGCTT CTACCTCCCA GCTCAACAGT CCTCCCACCT CAGCCTAGTG AGTAGCTGTG ACTACAGGCA TGTGCCACCA TACCCCACTA CTTTTCATTT TTTATTTTTT GTGAGATGGA ATCTCACTAT GTTACCCAGG CTGGTCTGCT GATCTCAATT GATCCTCCCA CTGTGGCCTC CCAAAATGCT GGGATTACAG GCATGAGCCA CAATATCTGG CCCCAGTAAG CTTTTAAGGC CATTAACATG AGGAACAGTG TTCTTTACAC TATTTTATCA GCTAGGGCTT TGCATGGAGT AGGAGTTTAG TAAATGCGGT TGATGGGTTA ATCAATGTGT GAAAATATTC AGAGCCACCA AAAACAGATA TTATGTCTAT TCTCATCAAC AATCAAAATT GAGTAAACAG CCATTTTCTA ATACAGGAAA CCACAAAACA TTGAATGGTG ACATTAAAAA ATTCCCCCAG CAGGAGCCAA CCAATTTTTT CATCCTGATC CAAGTTAGCA AACTGCAAAA GATAGGAAGC ACTAATGAGT GGAAATTTGA GTAGAAGCAT TTCTTATGAA GGCTGTCTTG ACTGGATCAC ATTTTTATTG CTGTTGGAGG TGCCAAATGT GTGTGTTTAT GCTAATCCTC CACCTCAGGC AACACACAGT CAAGGATCCT ACCAAGTGTT ACCGTCAAGT GTCTGTTGGC AGCTCAAGGC CCCAGCGTTG TTCCCTTGCA CTAGGGAAAA GACATATTCC AGGTACAAGT ACTCCCACTT TGATGCTACA GAGGAGTTGC TGAACTTTGT GTCATTAATC TCTCTTCGTT AGATCCCAAC CCTGTTTAAA TCCCACTATC TGCCTACTCT GGGTCTTCAC CAATTTACTA GATCATAGTT GGAGAAAATC TACAAAGCCT TGCTCCCTTT AGATTTAAAC AGGTCTCCGT TTAAATTTAG AATTGCTAAC TTCAAGCGGG CCCTTATGCG ACAGTATGCC TGTCAGTCAT ACTACATTTC CTCAATTCCA TTCATGTGAC TGCTCCATAC CCTTCCCTCT CTCTTCATAC bPI-109 68

TACTATTATC TCTTCCCCCC TCCCTCATTT TTAACTGATG ATCTTGTTTC CTATTTCTCT GAGAAAATAG AAGCCATCAA AAGAGAGTTT CCACAAACTC CTACTGCCTT ATCTAGCCCT GTACCATATA CTTTGCATTT CCTCTCATTA CCATGGATGT ACTGCCTATC TGTGCTTCTA TCTAAGGCTA ACCCTTCCAC TTCAGTTTTG AATATTATCA GCTCTTACCA ACTCAAGGCC ATTGCTCTAG CAATTCTCTC ATTCTCTCTC ATTTTCTTCC ATCAAGTTTT CCTTTTCTTC AATTAACAGA GTAGCTCCTA AAGGGAAAAA AAAGTCTTCT TTTTCAATGC TCATCATCAC TGGCCATCAG AGAAATGCAA ATCAAAACCA CAATGAGATA TCATCTCACA CCAGTTAGAA TGGCAATCAT TAAAAAGTCA GGAAACAACA GGTGCTGGAG AGGATGTGGA GAAATAGGAA CACTTTTACA CTGTTGGTGG GACTGTAAAC TAGTTCAACC ATTGTGGAAG ACAGTGTGGC GATTCCTCAG GGATCTAGAA TTAGAAATAC CATTTGACCC AGCCATCCCA TTACTGGGTA TATACCCAAA GGATTATAAA CAATGCTGCT ATAAAGACAC ATGCACACGT ATGTTTATTG TGGCACTACT CACAATAGCA AAGACTTGGA ACCAACCCAA ACGTCCAACA ATGATAGACT GGATTAAGAA AATGTGGCAC ATATACACCA TGGAATACTA TGCAGCCATA AAAAATGATG AGTTCATGTC CTTTGTAGGG ACATGGAGGA AGCTGGAAAC CATCACTCTC AGCAAACTAT CACAAGGACA AAAAACCAAA CACTGCATGT TCTCACTCAT AGGTGGGAAT TGAACAATGA GAACACTTGG ACACAGGAAG GGGAACATCA CCCACTGGGG CCTGTTGTGG GATGAGGGGA GTGGGGAGGG ATAGCATTAG GAGATATACC TAATGTTAAA TGATGAGTTA ATGGGTGCAG CACACCAACA TAGCACATGT ATACATATGT AACAAACCTG CACGTTGTGC ACATGTACCC TAAAACTTAA AGTATAATAA AAAAATATAT ATATATATAT AAAACAACTA AAAATAAATC TTCTTTTTCT GCAGGATCAG TCCATCACCA CACACACAGG CTGTGTTTTA TGTTGTTCCC CAGCTTAAGA GATCGTTCTC CAGATCCCAC TGCTCCTTCC AGTTGTCACC TCAGTTCTCC ACTTCTTTTT GCTGATAAAC TACTCTAACT AGTTACATAT GATTTCTGTC CCCAGGTCCC CTCCCTCAGT TGTTTTGAAC ATAATCATTT ATATCATTTA TCATTTTCAC TCTAATTGCA CAACCAAAAA CTCCCTTTTT TTTTAGATGG AGTCTCACTC TGTCACCTAG GCTGGAGTGC AGTGGCATGA TCTCGGCTCA CTCCAACCTC CGCCTCACGG GTTCAAGTGA TCCCCCTGCC TTAGCCTCCT GAATAGCTGG GATTATACAC ATGCACCACC ACACCTGGCT AATTGCTTTG TTTTTGTTTG TGTGTGTGTG TGTTTTTTTT TTTTTTTGGA CAGAGTCTCA CTCTGTTGCC CAGGCTAGAC TGCAGTGGCA TGATCTCAGC TCACTGCAAC CTCCACCTCC TGGGTTCAAG CGATTCTCCT GCCTCAGCCT CCCGAGTAGC TGGGACTACA GGCATGCACC ACCATGCCAG GCTAATTTTT TTGTATTTTC AGTAGAGACC AGGTTTCACC ATGTTGGTCA GGCTGGTCTT GAACTCCTGA CCTCAAATGA TCTGCGCACC TGGACCTCCC AAAGTGCTGG GATTACAGAC TTGAGCTACT GCGCCGGGCT ATTTTGTGTT TTTAGTAAAG ACGGGGTTTC ACCATGTTGT CCAGGCTGGT CTCAAACTCC TGACCTCAAG TGATCCGCTC GCCTCAGGCC CTCAAAGTGC TGGGATTACA GGAGTGAGCC ACCATGCCTG GCCATAAAAC TGCCCTTTGT TAATATGACT GTTGGCCTGC ACATTGTCAA ATCCAGTGGC ATTCATCTTA CTCGGCCAAC CTACGGCATT TGACACTGTC TGTCTTTCCT TCTGTTCCTC TATCTGTTTC CAGTATACTG GCCTGGCTTT CTTTTTACCT CTTTTATATG CTCTTCCAGT CTCAGGCTCC TTTGGGGATT TGAAGGTATG TTGCATTTTG CTATTCAATG AATAATGACA AGTAATGATC ACTTAAGACA TTAAGTGGTC AGTTCCTTTA CTAGGATAAA AATAATTTTC TTCCCAACAT GGGGCATATT CCATTTCCAG TCTGACTGTT CTGTGTAATC TTTGTATTCC TTGGCAGCCC CTTTTATATC AGTTCATCTA CTGTGCAGGA AATTGGACAA ACATTTGCAC TGGTATAACC AAATACAGTT GAACTTTTGG CTTGACTCTT AGCTGAACTC ACCAAAAATA ATTTCTGTAA GAGACTGAGA CGTCTACGAG TAGGTTTTTC AGAATTAGTA AACATAAATC AAGGATACAC AGGTAGATTT GAATTTCAGA TAAACAACAA ATACTTTTTT AGTATGTCTA CTGAAATATT TGTATCTTAT CTGGCAATTC TACCTGGTAC AGAACTAATC CATTCTCTTG AAAGATCTTG ACTCTGTAAT AAGTTCTTTG GTGATGGAAG GGAGGTATTT CTGTAATTAG AGTCACTGTC TTCCTCCCAG TTTTTTATCC TGGCCCAGAT CTGCAATGAA CACACGACAG AATCCAGGGG GGATGAAGAT GGGTGCTTTG CAGGAAAAAA AAATTAAAAA CATCTGAAAA AGCTTTTGTA CTAAAAGAAT GTGATCTAAA AAAGAAAGCA GGAGAACTTT CTGTCTGCAC TTTACATCAG AACAACCTTG GCGTCTAGAA GCTGTGCCCT GTGGGAAGTG GTGGTGCTTG GTAAGAGATG CCAGGACCAG TGGTACCCAC TGGGAGCACT GCCAATACCC AGCAAGGAGC ATGGGTGCAC AGTAAGGCAT TGCACTGTGA TTCAGCATAA AATAACAATA AGGGAACGTC ACGGAGAAAA GGCCAGACTT CCTTTGTTTA GAATGTGGGA AATGTCTTCT GAAAAATGGT AGTAAAAAAG CATGCTTGGA TGGTCCACTC CAGGCAAAAC TGACTAATCG GGGGTCAGGG ATACAACCCC TGCATCATAT GTTTGTTTCT GTTGGGCTGA CATGAGGTTC ACTGTGACCA CTGTGGTTTA ACCCCATAGT CTCCTGGAAA TACAGCCAGG TCAAGAGAGC TCCACATAAA ACATAATCAA AAAAATAAAC TCAAGTTTCC ACTGATCAGC TTTTCACAAC TCTTATCCTT TCACTAACTT TGGAGCAAGA TTTGAGAATT GGATGGCTAT TTGAGGGCTA TTTCTGCGCT TTAGTTCAAT GTTTTGTTCT TTCTTTATTA GAGAACTATG GTTTTTTATT ATATTTACAC TTTAAGTTCT AGGGTACATG TGCACAACGT GCAGATTTGT TACACAGGTA TAAATGTGCC ATGTTGGTTT GCTGCACCCA TCAACTCGTC ATTTACATTA GGTATTTCTC CTAATGCTAT CCCTCCCCCA GTCCCCCACC CCCCGACAGG CCCTGGTGTG TGATGTTCCC CTTCCTGTGT CCAAGTGTTC TGTTTATGTG ATAGATTACG TTTATTGATT TGTGTATGTT GAACCAGCCT TGCATCACAG TCACTTGCTT ACAAGAAACA AACACTTCAC AGATGGATCA TTATGTGTGA TAAGTGAAAT CCAAGGATTT ATGCTCAGAG GTGGGCTTAA CAGGTAGGAA GAGCAGTATT TTCCTTCAAC CATGAGTGTA TGCAGGTTTT TCTTTTCTTT TTTGAGATGG AGTCTCACTC TTTTACCCAG GCTGGCGCGC AGTGGTGCGA TCTTGGCTCA CTGTAACCTC TGCCACCTGG GTTCAAGCAA TTCTCCTGCC TCAGCCTCCC AAGTGGCTGG GATTACAGGC ACCTGCCACT GTCTCCGGCT AATTTTTGTC TTTTTAGTAG AGATGGGGTT TCACCATCTT GGCCAGCCTT GTCTTGAACT CCTGACCTCA TGAATCATCC TTCTCAGCCT CCCAAAGTGC TGGGATTACA GGCATGAGCC ACTGCGCCCA GCCCACAGGT TTTTCAAAGA CTAAACTTAA AAAAAAAAAA AAAATTTCCC AATGAAATAT AAAACTAAAG TGCTAAACTG TGATAGACTG TTTTACAAGA ATGCCAGTTT TCACAAGTGT CTATAGAACA TGTAATTTAG ATAGGTAAGA TGAAATTTTG ATAATATTTG ATGGCAAATT TAAACAGGTA TACAACAAAA ATAAAATTCT AAGCCCCTCA ACCAACTGAA TGGACTCCTT CTCTCAGCCA AAGGAATACC AAAGTAAACC TGAAAAACTA GTTTTGGCCA GGATTGGGGG TAGGTGGGGG AAGCCCAACA TGACTCATTA TTCTCTCCTC CCTTTGGAAT TCAGGCACAA CTGAATGTCA GCATTGACAC TAAAACACAG ATCTTAAGAC TGACAAGCCA GACTCTTTGT AGCAGAGAGC CAGGCCCTGG AAGAAATCAA GTTATTTTAT CCCAAAAAAT ATTTCTTTGA TATATTTTCA AATGGCCCTG CAAAGCTGTC TCTTGTGGGG AAAATTGACA TGCTGTACAG AATTTCCTTC TCTTTCCAAG TTTTTACTGA TCCAGGAGAG ATTTAACTAA GAGGCTAGCA TGTTTTTTTT TTTTTTTTTT TGAGGCGGAG TCTTGCTCTG TTGCCCAGGC TGGAGTGCAG TGGCGTGATC TCAGCTCACT GCAACCTTCG CCTCCCGGGT TCAAGCGATT CTCCTGCCTC AGCTTCCCGA GTAGCTGGGA TTACAGATCC ATGCCACTAT GCCCAGCTAA TTTTTGTATT TTTTGTAGAG ACAGGGTTTC ACCATGTTGG CCAGGCTAGT ATTGAACTCC TGACCTCGTG ATCCGCCCAC CTCGGCCTCC CAAAGTGCTG GCATTACAGG CGTGAGCCAC CGTGCCCAGC ACAAGACATT TACCGTCTAT TCTCTCTGAA GCTACTATCT AGAGGCTTCA TCAACATAAT AAGACCCTTG GTCTCCACAA CTCCTTATCT TATCCTATTA GTTTCTACTG ATTCCAGGTC TTTAGATAAT AACAACTCTT TCAACCAATT GCCAATCAGA AAGTCTTTGA ATCCACCTAT GACTTAAAAG CCCCACTCCT TCAAGTTATC CCGCCTTTCT GGACTGAACC AATGTACACC TTATATGTGT TGATGGATAT CTGCCTGTAA CTTCCATTCC CCTAAAATGT ATAACATCAA GCTGTAACCC AACCACCTTG GGCACATGTT TTCAGGAACT CATGAGACTG TGTTGCAGAC CTTGGTCACT CATATTTGGC TCACAGTAAA CTTCTTTAAA TATTGTATAG AGTTTGGCTT TTTTCATTGA bPI-109 69

CACAGGAAAA ATAAAGAATT GGAAGGTCTT TCATCAGTCA CTGAGCCAGC TTCATATCTG ACTGAGGTCA TACAGTTCAG TGATTTGTAG CTTTGCTACT TAGATTGCTA TCCATTATCT AGAAGCATCA GGATCACGTG GGACCTATTG GAAATGCAGA CTTTCCTCCT AGAACCCAGG ACCTTGGAAT ATTCTTGGCA CATAGTAGGT GCTCAATACA TATTGAACTC CTAGGTGCAA TTCATTAATT CATGAATTAA TGAATTAACA CGCTCTCAAA GTTTAGTGCT TTTTCACAGA CTAGTCTTTC TGCCTCTTAA GCACTCAGCT CACCACGCTT CCAGTCTCAC TCCCCTATTA GTCTGATTAA AATCTGCTTA CATGTGAGTC TGAGATCAAG TGTTATCTCT TCTGAGAAGT CTTCCCTCAC TGGCCCAAAG GAATTTCTCC TCTATTTTAG CACTGTCCCA GTTGACTTGT CATTATTCTA GTCTTTTTCA TATTAGTTGT TTTTCATATA TATGTTATTA AGGAAACTAG TCATTTCCCC TAATAGAACA AAATTGCTGG CCTTTGGGGT TGGCAATGGA GGGGAGGCTC TTCTTGAAAA GGGGGAAGAG TGTTCTCCTA ATATTTTTCT TACGAGATTT ATGTTGCTCA TCTTTAGCCT TTAGTCCCCC ATTGCCTGCC TACAGTTGGC AGAGACCATC TGTTCTCTCA CTGTCAGGAA CTGTCTCAAT TCTTGAAGTT CAGAGTCAAA AAAGAAGCAA GTTTTCCTAG CTCTTTGATC AACTTTCAAA GTTTTACTTC CATTTGAAAA TTTACTAAGT CACCAGGAGA TGGTTTATAC TGAGAAATAT CCACTCATAC TCTTCCTCTT CAACTTTCTT CCATATACAC CCTATTACAG GGATATAGTC TTACTCTATA GCTCAAAAGG ATGACCCTAT CAGAAACCTG CACAGTATGT AAAACATTCT CACCAGAGGT TCACTTGTGT ATTTCCACCC TAGAATGGAA GCTCTACAAA AGCACAGAAT GTATCATTTT AACTTTAGAT TCTATTTTCA CACCCAGTGC TTGACACATG ATTTGAAGTT AATATTTATT TATCAAGTGA TTGTTTTAAA ATCATGACTC ACTCAACAAA GTTATAAGAA TAAGAATAGT GTTACAGAAT TGGTATACAC AAGCTGACCA TAATCAACAC ACCTATTATC ATTTTTTTGC GACAGGTTCT CGCTGTCTCA CCCTGGCTGG AGTGGAGTGG CATGACCACG GTTCACTGCA GGTTTGAACT TCCAGGCTCA AGCAATCCTC CCACCTCAGC CTCCCACATA GCTGAGCCCA CAGGTGTGTG CCACCATGTC CAGCTAACTT TTTAATTCTT TGTAGAGACA GGGTCACCCT ATGTTGCCCA AGCTGGTCTT GAACTCCTTG GCTAGAGAGA TCCTCCCTCC AAGGTCCCCC AAAATGCTGG GATCTCAGGC AAGAGCCACC ATGCCTGGCC ATAATCAATA CACTTTTAAG AATGCTAGAA TGTTATATCA GATGCATACT TCAGCACTAT CTCAAGCAAA CTGGGGTGTG GGTTATTCTA CATATAAAGT TCAGCAGTGT TGTTCCACAG TCCCAAACTC CAACTGAGGT CAAATGTAGG GTGCAGCAAG GTCACTGGGG CTGTCATCAA GGGCCTCTCC TTGCACTCTT GCCAACCCTG TTTCTTGATT GTCTCTACCA CCATGAGTCA CCAGCAATCT CCCACAGTCA CTTGTTTAAA AGTTCACAAG TATTGTGTGA ATTGCAGGCA ACCCCTTGAC TCCCTGATTG CCTGGTCTTC TTCCTTGGGC TCTACCATTT TTTTTCCCCA GCACTCTTTC TGCTGCTCTA AATTTTAATT CATGCAATTC CATATGTGTT TCTCTATCAT TCTTCATCTC TTTCCTCTCC CTTCCATCCA ATTTTGTTTG TCTGTTTGCT TGCTTGCTTG CTTTAATACA TTTCTCTTTT TCTGAGAAGG CTTGAGTCCA AAACTCTCAG TTACCTGTTG TTCTGTTTCC CGTTAGTTAA TCTCCGAACC TTCATAAATT AAATCTGACA AAGTCCCCTG ACTAACAAAG GAAATGCACA AGTCACAGTA AAAGGGGCAC ACACAGAACA CAAATAGACC CAGGGTCTTT TCTGTTCATC ACTCAGCTTT TTATAGGAGA TCCAGGAGAA ATGAAGTGGA AAGGGAAGTG TGTTGAGTTA CTATACAACA CAAGAGTAAA CTTTCTTATA AGTGGTAATT TTTTTTTACA GGAATAATTG AAAATGGAAA TTACCTTCTC TACTCATAGT AAGTACTCAG TGCGTTCTTG ATGGGATGAG AATGTGTTTG AGCTTTAGTG TAAGGCAGAA TTCTGTTTAG TCTGCCAGTA TTGGAGAAAA ATAAAACACA AAGGGACTGA CATGTAGGAA GTGGCACCTG GGAGGGTCTC AATTCTTCCT ATTACAAAAA TGCCCCAGAG AAATAAAAAG CTTGTGTACA TGTTGAGATG GGAGAGTTCT CTGGCCCCCC TCGCAGGATG TGTGACAGTG GGGTGGCTCT CTGCTGCGCC ACCATGAGCT CAAACCCCTC ATAGGAGGGG GAGCACACAG GCAGGAAGGT GCAGGAGCTG GGCGAGCTCT TTGGGCTCTG GCCCCGTGGT ACTGTCTAGA GGTGGGTGCC TGCAACTCCT GAAAGCCCAA GTGGGCATGT GTTACAGTGC ACTCTTTCAG CTTTGCTGTC TGCAGCTTAA GCGTTAACCA GCTCAGTTTC TTCTTGGTAC CCAGGTCCTT GTCTGGCATC CAGGAAGAAT CAGGTTACAC ATGGACTTGA AGGATGAATG TGGGAGTTTT ATGGAGTGGT GGAGGTGGCT CTCAGTGGGA TGGATGGGGA GCTGGAAGGG GGATGGAGTG GGAAGATGAT ATTCTCCTGG AGTTTGGCTG TCCAGCAGCC GATCTCCTCT CCAGTCGTCC CCAGCCTCTC GACGTTCAGA TGCTCCTCTT CTCTCCTTCT CTGCCATGCT GTTCTGCCGT TCATCTGCCT GTCTCTCTCT GGAGCCTGGA ATTTGGGGTT TATATGGTAC ACAATAAGGG GCATGGCAGG CCAAAAGGGA ACTTTTTAGG TGCAAAAAAC AGGAATGCCT CTTCTCACTT AGGGCTATAG ATTTTCAGGC TTGAAGGTGG GGCCTTTACC AGCGAACCTG TATTTCCCTG TCTCCTGTGC ATATCAATGT AATCAAATAC TGGGCTGATC CAGGATGTTT CTTTAGACCA ATTATGGGTA AAATAATTTA CATTCAGGTT TTTATATTTG CTTTTGTCAT TTCTTTTTAA GCAATCATGT AAAATATCTA TACGACAGTA ATAGATGATA GCGAACCTAA TTAAAATTAC CAGAAACTTA AGAATCTCTA ATGATTTCAA CTGTAACTAA GGTTATTTCT CTTTATGTTG AACAATGTTG GGAGATAAGA CACAAGAGTT TCTGAAGTAT TTCAGAAACA CAAAGAGGGA GGTTATATAA ATAATATTTT TTTCCTACTT TGGGAAAATG AAAGCTAGTC ACAAAGTTAA ACGAGTGGTT ATTTTAATAT TTAAAATACA GGCTTGGATG TATTTCCTGT TAAAGAAAAT AAAATGCAGA ATATTCAAAA CGTCTGACCA CCCTTCTAAG AAAATGCATC TCTGAGGTAT TTTTCCTTAG AAGTTATTGT AAAAATCCTG GAGAAGCTTG AACACAGCAA AGCAAACAGG ATGCAGAGTT TAATCTGTGG AAAGCTTAGG GAAGAAAAGC AAATCATTAA AAATAGGTCT TCCTCTGAAG ATTTTTAAAA CGCAAAGAGG GTGGAATAGC AATGATAATA AAAAAGCTGG CATAGAGAGT GGCACAATTT GCTGTGCCAC TGAGCTGACT GGATGTGTTC TGAATTTCTA GGCATTAGTG TACCTTTCCA CACGCATTCT CCCTTTAAAA AAAATGCCCA CACACTGAAT ACTTTTTTCA TGCAATTTAA AATAAGCGCA CCATCTAGTT TACAGAAATT CACTAGAAGT TATTTATCCT AAAATAGCAG AGATCTAGAA GAATTTTGAG CTCTAGGACA TTTTAGACAC ACAGAAAGAA GAATCTGGAC AAGTCTTGAC CAGACATGAC AGAATAGAAA TTTCTTTTCC TATTTATCTC TTTGAATAAA ATTTTCAGGA TCTTACAGTG GACAAGTTTG TTATCTACAC ATTGTGAAGC ACATTGATTT CTCCTCTGTA GCCTTAGGAA GATCTGAGAG GTGACTGAGC TGATTGAATG ATCCGTGACC GCTCTACTGG GACCAGTAGT AGAACTTTAC TGGTGGAGAC CTGCTGGAGG TTTGAGAGCA GACTTTGAAA ATTACTAGAG CTACACAGAT ACTGTGTGGC TAACTGGATT ATGTTTAGAG GCTTTCAGAA CTATGCTGCT GCTGCTGCAG TGTAGCCAGG ACGCACAGAG AACATCTAAG GCTCTTGAAT GGGGCGATAG GGACAGATTT CAGCAGCCAT CTGACTTCAG TGCTCATTTT GATGCTTTCC CTGCAGGGTG CAGTGTGCAG TGTGCAGTGT GCAGTGGTGG GAGGCTCACA CAGGAATACT TGCTTCTGTA GCCCTAATTT CCGGTTCAAA CTCTGCATTC ACCTTGACAG ATTCTTTCCT TGGCCAAAAT TTAGTTAGGC TTCTGGGCTT TCTCTTATGC CCACCTGCAG ACTTTTTGGT AAAATCCAGT TTTAGTAAAG AGCTCTGCTA AGTCAGTTTA GCAAGAATCC CCACCTCAAA AGTCACTATC TCCCTCCCTG GTAGTGTCTG GCTTGTCTTC AGCGAGAATT CTATTAGGTT CTGTTAGATT AGAATCCTCC TTACCCTTGA TGCTTCCTCT TAGTATTTTT TCATCCACTG ACTCCTTGAC CCACCTTGCT CCTCGGCTAT AAATTCCCAC TTGCCCATAC TCTGCAGTTA AGACTATTTT CTCCCCACTA CTGCAAAATC CCATTGCCAT GGTCCCTATA CTATCTCAAT GGTAATGAAT AAAGTCTGCC TTACCATGCT TTAACAAGTA ACATTGAACC ATTTTTTTCT TTAACAATCT GCTGCACAAT GAGATTACTA AAACTTTATT CCATTTTGCC ATGCTGGATG TCCTCAATGG AATGGCTCTT GTGAGCACCA AATCATTGTG AGAAGGAAAA CCCATCTCTT ACAGCCCCCT GTAACGTGAT GTATGTTACA TGTGATGTAT GTTACATAGT TrTTTTTCAT GTTGATCACT TTTTGCCCAT TTTCCTATAT CTTATCAGTT GGAAGACTGT GGAAGTTTGT AGTACTAAGC CACAAGATGA CTAAGAAGAG TTGAAAGGGC AAGTGGGGCT AAAAACAGAT TTTGTTTGAC TTACCCCACC ATTCCCCCTA TCATGGGGCT GAATCTGCCT GGAGGAAGGA GCATCTTTAT CTTTGTACTG TGAACCACAC EPI-109 70

AGTCTAGCAG CAGCACAGCC AAGGCACTTG GGGTTTCATG AGACTAAGTA CATGCAATTC TATTGTAAAG GCTTAAAATA TATACAACTG ACCCTTGAAC AACATGAATT TGAATTGCAT GGTCAGTTAT ACGCAGATTT TCTTCCACCT CTGCCACCCC TGAGACAGTA AGATCAATCA ATCCTCTTCC TCCTACTCCT CAGTCTACTC AAAGATACTT GAAGTCTACT TGAAGATGAC AAGCACAAAG ACATTTATGA TGATCCACTT CCACTTAGTG AATAGTAAAT ATGTTTTCTC TTCCTCCTAA TTTTTTAACA CTTTCTTCTC TCTAGCTTAA TTTATTGTTA AGAATACAAT CTATAATACA TATGACATAC AAAATATGTC TTAGTTGACT GTTTATGTTA TCTGTAAGGC TTCAGGTCAA GAGTATGCTA TTAGTGGTTA AGTTTTCGAG GAGTCAAAAG GTGTATGTGG ACTTTCAACT GCAGGGGGGT GGGCACCCCT GCCCCCATGT TGTTCAAGGG TCAACTTTAC TGCCAAAGGC AAGCCTTTAC ATCCACTTTT TCCATCCCAT CAGTAAATGG AAAAAGATAG CTACAGTATC CCTGCGTCAA ATCTTΓTTTT TTGCAGATCA CAAATTGGCC ACTCACCTTG CTCTGTGAGG GGTAAAATGC CCCACTTTCT TTAGTAATAT TTAAGTTAGA TAATATTTAA GTTATAAAGT TGTTCTTTGT AATCGTTAAT TGTAATTTTT ACATAGTTTC TTTCAAACAG AAATAGCATT TTTGTTAGAT AACCTCCCGT ATAGATGATG AAACTCCTTT TAAGGGCTAT CTGAATTTTA ATTCCTTGAA AAGGCAGAAA TTGGATAGCT AGTAGTCATA AATGTACTGT GGCTTCCCCC AACCATCTGG GCTATATAGA AGCTGCATCC TTGGACTGCA GTAGAGGAGT CTTACAAAGC ACAGAGCAAC TTCTCTCCTG GGTTGCGCTA GTTATGATGG CAATTTTAAA TGTGTACTTT TACCCAAAGA AAATCCTTAT TATCAACAAT CACAATGCCA TCATAACCAT GGTATAAAAA ATTCAAAATG TCCCAGCTGA AGTGGAGGCA AAGACTCAAG TTCATGGAGT CAGAGTTTCC TTGCTATTCC TCTTTTTCAA ATGACCATTT AGTAAGCACC TGAAGAAAAT ACTATGGACG GCATTGAAAA GTGAAGATAG GTTTAATCTT CTCGAAAATC TAATTCTCCA GATGAAACGC TGACACTTAT CCACCCCACA GACCCTATAG CAGATGTGTC ACTGGCCATC ACATTTGACA CAGAGAAGTC ATAACTCAGT CAGCACAGAG ACATTTCCAT GAGTTTCTGA ACCATGGACA GAACGTCGTC TGTGGGACAT GAAAACTGGA ACTTAGAGGA CAGGCACATC TGAGAAATGG GCAGTTTAAA GGCAGAACAT AGCACATATG TGACTGGGTT TTAGAAGCAA ATTTACAAGA CGCACTCTTC TTCATCCTAA ATAATCTGCA ACCAAAGCTT CCAAAAAAGA CAATTTAGGA ATGCAGAGGT GAGGAGTAGG GAGGGGAATG GGATGAGAGA GAGTGGAGAT TAATGGTGGG CAGAGCGAGG TTTAGAACTT AGTGGTTTCT TCAGGTTCTG AACTGAAATT TGTATACTGT AAAGGCACAA ACACCATTTT TAACAAAAGT GAGCAGGACT TCCTATCTGG TTCAGAAAAT AGGTGAATAA ATAGTACGAA TTATTAAAAA TAATAATTTC CACTTATACA TAGGAAACTT GATAGGAACC ATGATAAATG CTTAACTCTT AATCTTCAAG GAACTCTGCT AGGGATATAA TATTATAAAT CTTGTTTTGC AGATGGAGAA ATTGAATTTT AACCCAAGTT ATCATAACCC TTAAATGATT AAATGATACT GTTACATGAG AAAGCTGCGT ATCTGTTTCC TGGATTTGTA GCCATAATTT GTGTCTCAAG TCCCTTTTGC TGCCAGCTAT CTTGGGTAGG TGTGTTCCCT TTGGGCTGTT TGATACCCCC ACATTTATCT TTTTTTTTTC TCTTTTTTTG TTGAGAGAGT CTTTCCCTGT TGCCTAGGCT GGAGGGCAAT GGCGCGATCT CGGCTCACTG CAACCTCCGC CTCCTGGGTT CAAGTGCTTC TCACGATTCT CTTGTCCCAG CCTCTCTAAT AGCTCGGATT ACTGGCATGC ACCACCACGC CCACCTAATT TTGTATTTTT AGTAGACAAG GGGTTTCTCC ATGTTGGTCA GGGTGGTCTC AAACTCCTGA CCTCAGGTGA TCTGCCTGCC TTGGCCTCCC AAAGTGCTGG GATTACAGGT GTGAGCCACC ATGCCTGGCC CCAAATTTAT CTTTAATGCC CCAAATTATC TAGTTCCCAT GACTGGGCTT CTGCTTTGAT CCTTTCTGCA CTTGCTGGAC CCTCTCCCTG GGAAATGAGA TTGTGTCCTG AGCCCCTAGT TAGAGGCTAT GTCTCTGCTG TTCCTGAATG GGCCTCCTGG ATGAGACCTC ATTAAAAGTC TAATTCTCTT GGAGAATTGA GAGATACCTA TTTGTCTCAA AATCATTGAA ACCAATTAAT GTATTATGAG CCTCTATCCA GTGATTTGTA CCTCAATTCC CCAATCCAGC TGTCAAGGCC AATTTGTTCT ACCTTACCTA GTAGGTAAGT CTGGAATTGT AGCTGTGGCA TTTTCAGTAA TGGTACTCTA GGTTAGCAGT CCCCAACCTT TTTGGCACCA GGGACCAGTT TTGTGGAAGA CAATTTTTCC ATGAAGGGCT GGGCAGGGGA GTGGTTTCAG GATGAAACTG TTCCACCTCA GATCATCAGG CATTAGATTC TCACAAGGAG TGCGCAAGCT AGATCCCTCA CACATGCAGT TCACAATAGG GTGTGCACTC CCATGAGAAT CTAACACCGC TGCTGATCTG ACAGGAGACA GAGCTCAGGC AGTAATACTC ATTTGCCTAC CGCTCACCTC CTGCCGTGCA GCTCAGTTCC TAACAGGCCA CGGACCAGTA CTGGTCCACG GCGCAGGCAT CAGGGACCCC TGTTGCTAGG TATAAGCATC TGGCTGCTGC ATGTCTTCTG TGTAGCTACA TCTGTATGTG TATCTGATGA GATATAAATT ATTTGATTAT AAATTACTTT CTTCATATTA GAGTTGTGAA TGAGTATCAC ATATAATTAT ACATAAACTA GGAATATGCT TTTTAATAAT GTATATAAGT AAGTTTCCTT AACTATGACT TTCATCTTAG CGTAGTAAGA GGGTGCTAAG AAATATTTGT GATGAAAATA GGCATTGGTA GAGTTGAGAC CACTGGGTGA TGAAAGAGTG TAAAGATTTT AAAGCCTTCA GATGCTGGTT CAAGGTGAGA AATGTGATTG GGAGCAAATC AATTAACTTC TTGAAGTCTT ATAGGGCAGT TATGAATACT TAATGTTAAC ATATGTAAAG CTCTTCTGCC CTGTATACAG TAAATGCTAG TTAGCTATTA TGATCACTAC TAAAATGGGG ATGACATAAA CCTCATAAGG TTTTAAGTAT TATGCAAGAT ACTATACAAA GTCCAGTAAA TATCACATTC AATTGAATCC ATGATGTCCG ATTATTTTAG CTACTTCCAA GAGAGAAAAA AATGCTGTCA GTTTTACTGT TCTTATAGAG AGCAAGGCAG ATCCCAATTC CCAATGTGGT AACGTGAAAA TTTTTGCATT TGAATCAACA AAACACTTTC TCCTTTCTTT CCTACTATTT AACAACTGGT AAGTCTATAC TCCCCCAAAT CTGGAATTCT CCTTTCTTAT TCTTTTTCCT CCTACCAAGA CCGCAGGATC TTTTACTTGG CTATAAGGGG TAAACCTCAA GTAGTACAAG TTCTCTGTAT TACTTTTATA CTCTGTCACA GATTCCCTTT GTTTCCTCAT CTCCATGTGA ATTTAGTTAA ATTCTCAGCA TTCTGATCCT TACTATACAA GGTAAATGAA TATAAAAACA AAACGAAACA AAAACCTCTT CCTATTTACA TAAGGCCCCA ACCTAATATT TAGTGATATA TATTAATGTG AACAAGGAAC TAACGAAGAC TGGGAAGAAA TTCACAGACT TGAGAGAAGA AATGGCAGGA TTTCCTGGGA ACAATTTCAT GTAACGTCAA AGGTGGTAAA AGGTCAAATA GAATGAAGAT GGAGAATACC GGATTTTCTT ACAAAATGAT TTCCCAGGAG ATCTCATCAA ATGCACGAGG ATACCTTCTC AGTTTCACCT AGTGAGTAAA AGACTGGTAA CATAGCTCAC TTACAATTTG GATAAACAAA ACTAAACAAA CAACATCAAA ATTTCAGAAA AAATAATAGC AAAACAGAAA TCAAACACTC AAATTTTTGG TCCTTCTGTT TATTTCATTT TGGATACTCA GTGAATGTTA ATTAACCAGG AAACTTAAAA GTTATTTCAA TTATGAACCT CTTCAATCCT TCATCAATTA TTTTGAGTAT TCTGGTCTTA AAAACATCTC TTTCTTCTAC AAACTTCTGA AAGAGATGAA CACCTCCACC TACACCAAAA TAATGTGCTT TGCTGGCCAA AAGTACACGT CCATTTTTAC TTAACAGTCT AAGGAAAGTC TGGTGCAAAT TACTATAATA ATCTGGGTTG TAAATGGTTT CTGAGGTGAG AATGAGATCA TATTTTACAA AAAGTTTTTC ACTACTTAGT ACAAGCTTAC AAAACTCAGA CCACTCACCA GAAAAAAATC GGCATTTATA TAGTTGTGTT ACTTTTGGTT TCCTGCATCT TTTCACATCT GGCTCATTTA CATCATTTTC TTCATCTTCC AAAGTGGAGT TAGCTACTAC ATTAGGTAAG GTTACTTCAT CAATCACCAT ACTGTTATAA TCTTGAAAGT GAATTTCTTT GGACCCTCCC TTGAATGCAG TTATACCTAG TAAACCTGAT CCACAACCAA GATCCAAGAC TTTTTTCCCA GCAAATTTCA CTTTGGCCTT TGTGAAATAA GCCAGGAGGT CAAAGGTACA TTCCCAGATT TTTAAGCCTC CCTCATAAAC ACCTGTAATC AGATCAGAGT GAGAAGAAAA GCTTTTTGAA ACTATGTTTT CTCCAGGGAA GTTCTCTTTC AACAAGATGG TTTTCACTAC TGATAACTTA ACATGCTGGA AACCTGGTAA TGTTTCTATG ACTTTATTTT CTAACATCTT CTTTAAATCT TTAGGCATAG CATGCTCTTT GGCAGCTCTC AAGGAGGGCT GTTTTCCATG TGGCTCCAAG TTCCTTGAAC TGCTGGCTGC ACTGAGTGGA CTGTCTGTGT CTTGAGAGGG AGCTGCATTT TCCATTGACT TATGTTCCCA CAAGTGATCC TGAGGCAAGT CAAATTGTTC TGCAGAACAT TTTCTGTCCC TCTCTTCTCC TTTTTGACTT TCTGAGACTG ACAGCTCTTT TGAGGAATCC EPI-109 71

AGGGTCAAAG CTCCATCTCT AATGGGTGTT AATTCATTTT CCAGATGGTC TTCTATAGTG AAATTAAACT GAAAGGTCAT CCTCTTATTA AATGCACACA ATCTTTAAAT TCAGATTCTT CAACTTCTGG ATAGAATTTG ATGATACACA CAAATCTGCC TCAATTATTC AATTAGTTTT GTTGGGCCCA ATTTCTCTrT AGCAGCTTAT ACATGGTAAC AAATATTTAG AGATATTTCC AAATGACTTT TTAGACGTCT TTGGTCCTCT TTCCAAGCAG CTCTGGAAAG AAAAAAAAAA AAAAAAGAAA GAAAATGATG ATTAAAGCAA AATGGCACAT TTCACTAAAG TGTAATATTA AACAGCCACC CCCACCCCTC CCTGTCCCAC CATACAGCTG CTTTTTCTTA AAAAGTTGTG GGGAAGAGAG AGAGATAAGA GATTTGGACA CTCATACACA CCTTAAGGGT TCCAAAGTGG GAGAAGAAAA TCAACTATAA AAACAAACAG AAGAACAACA GCAACCACCA CCACTACCAC CTGGACAAAC ATAAAGTCCA AGATATTCAG ACAGGACAGC CTAGCTACTT GCTGTCTTTC AGCTGTCTTG ATTTGTGTCC AACCATATTC ACCCCCTAAG CTTCCAGAAT AACTTCACTT CTGTCTTTTA CAGAAGAGGT GCAGTATTTT ATTTTGGTAA GTCAGCGTCC CTTTAAAAAC ATGCATAGGT ATGGCCTGGT GTGTGTAAAT TCATCCAAGA CTTCACTCCA AACATTTAGT CGAGAACAGC AGCCCTAAGT GTATAGAAGT GGGGGTAATT TGGCAATAAT TAGTAAAGAC TAATTCGGTG GCAGAGCAAA CGCAAACTAG GGCACTGCAG TAGTTTGGAG AGACCTGTAG AAATAAGAAG CAACTTTATT GAGAATCTTC TATCTACTGC GCTAGACACT ATACCATCTG CCTCAATTTT CACAGTTCTG GCAAGTGGGA TCTTTGTTCC CTTTATACAA GATTTACAAT TTGGGGGAGA GGCGGGTCAC CCAGTCCCGC GGCTAGGAAC GCGCCTCTTT CCTCTCCCAT CACGCTGCAA GGCTTGGAGT CACTTCCGGC TGCAGGTCCC GGAACAAATC CGACCCCAGA AGTGGGGACT TCTGGCCCTC ACCTCCCCAT TTGAATGTAA TGTTTACAGT GATCCAGACC TGGGGATGCT TGCTTCCCGA CGTGTCCTGG GATCGCGCTT CTGAAAAAGC TCACCTCACA ACGCCTCCTC CGGACCTAAA TCGCGCACCA GTGAGTCGAG TCCTCCAGGG GCTAGAGAAG CCCGACTTTC TTTCCGGCCT TGAGGGACCC GGGCTCACCA AGAAACCAGC CGCCCTCCTC TCTATGGTTT TGGAGCCGGC GGAGAGCGCG CAAGGGTTGG CGGGACTGCG AGTTTCCGGT CTGGGCTTTG GCGGGTCTGG TTTGAAGCTC TCCTGTTTGA CGAAAGTATG TCTCAGGAAG GTGCGGTCCC AGCTAGCGCG GTTCCCCTGG AAGAATTAAG TAGCTGGCCA GAGGAGCTAT GCCGCCGGGA ACTGCCGTCC GTCCTGCCCC GACTCCTCAT ATCCTTCCTT GGTTGTCACT TCTACCTAGA GAAGGGTGTG GGCGGGTCGC GAACCTTTCT CTTCTGTCCC TTCAGACCCA CCGCCAGGCT GGGTTATATT ACCGCGGCCT GAACCCCCTC TTTTCTTTGT CAGTGAGTGG GATGAAAAGT GAGGGACTGG AGGGGAAGCG ACAACCGTGG TAGATTTAAG TAAGGCTTTG GCCCTGGAAA GCCTCGCGGA CGTGTTCTGA CCCAAGGTTT TAGCAGTGGA TGTGGCGTTT TCTTCCATTC CTTCTTTCAG TTTTTCTGTA CTCGTTGCTT GCAATTAAGT GTAAATACTT TTGCTAGTGG ATAATGGGGG AGGCAAGGAC TGAGACCTGC GGTATGACGA TAGCTCTGGC TCTTAATAGT TTGAGGTAAA GCGAGATACT CTGAGCTTTT GTCTCCCGTA AAAAGGGTGG TGAATATGAA TAAGGGCTTT CTTAGCGTTA TAAGAATTAA AGGGCATAGT TCTGTGGTGT GAAATCTTTA AAAGATGTTC AGTAAATAAA AATGATTTTC CTCCTTCCCC TCTCAGACCT CTTTTTCTTC TTTCTTTCTT TTTTTTTGAC AAGTTCTCAC TCCTCTCACC CAGGCTGGAG TCTTTCTGAA AGAGTTCTTC CGCTTGTTGT TGGCTTTCAA CTGTTGGATT TGAGGCGCTT AGCGCCTTCT TCGTCCGGGT GCAGCACATT CTTGATTGGT CTCATGCCTT TGTGGTTGTA AATGTGCCTG GAATCCTAGC CTTTCATGGT AAACCATATG TATATGTATC TTTTTCACAA CATTTGAGCC CAGCTTTATA CAATTACACT CAAAAGAAAA AAAGTAACCT TCACTTGAGA GAATCTCAAT ACTGCACAAA TATTGTGCAG CTAAAGCCCT ATGTAATCAC ATAGAAGTCA TTCACCTAGG CATTAGCAAA ATCTCAGAAG GTGCCAAAGC CCCCTTTTTT AGTTTTTGTG TAGGTACAGA ACTGCCGTCT TCAAGGAGTT TCAACTTGAA AACAAATAGC CACCCTCAAA ACATTCAAAA ACACTTAAAC TGCGTGCATA ATGTGTGTGA GACATGGTGT TAGGCTTTGG GAGAACAGAG ACACGGAACG TGATTCCTCT TCTTCCCCAC AAGCTTATAG AGAGACTTCA TTAAGTTGAA AGTCAACATT CCCACCTAGC TTTGCACTTC AAACGACATA TTCAAAAAAG CCCAAACTTC CTCTAGTTTT CTTCATCTGA GTAAATGGTT TCACAAACTG AAACCTTGAA TCCTCTCTGT CTCACACACC CGATCAGTAA GTTCTATTGT TTCTGATTCC AAACTATGTC TTGAATCAAT CCGTTTATCT CCATCCTCAT TGCTACCACT CTGATTCCAA ACCCTTATCA CCTCTCACTT GGAGTATTAA TAGTTTCCTT GTTTCTACTC ATAATTCATT ATTCCAAAAA AGTTAAGAGG GGAAAAACAT AGATCTCGTC ATTTCCCTTT TTAAACCACT TTACCTTCAA GGTTCCAGGT GATCTAAGCC TTGCCCTTCT CTCATACCTA GTTAATTAAC TACACTCTGT TCATGAATAC ATTAGGCTCA CCTACCTCAA GATCTTTTTG CTCAGCCTGA TTTGTTCTCT CAGCCTTTTG CATATTTCAT GTTTATGTCT TGGCCCAAAT GTCACTTCCT TAGAGGGGCT TTTTCAGAGC CTTCAATCTT AGGCAGTTCC CCCAAACGCA GTCTTACACT TGTATCACAT TGGCCTGTTC AGTTTTCTAA AAAGCACATT ACCATTAAAA GAAATGCTCT TGTTTGCTTT GTATATTTTC CACTTCTACA CATTATGTTG CAAAGTTCAT AAAGGCAGGA TGTTGATTTT CTTCACAGCG TTACCCTCAG CACCTAGAAC AGTGCCTGAC ACATAGTAAG CATTCATTAA AGGGCTAAAA ATATTTCATG TTTTAAAAAT ACTTGGGAGT CTAATTAGAC AATACTTTTT TTCAGCTTAA TGGTAGTATT TTAGCTTCAC TATTTTAACA AATGAAAAAT TTGCAATAAA TCTACAATGC CATTACCCCC CAAAATCTTT TTCATGTTTT GCATTTTACG TATTATTTTC CAGGCCTTAC CTGCATGTCT GCATAATCAT AACTGACTAA TTTTGGAACA GCTGGTAATT ATTTGAGCTT TACTGAAATT TTTTCATGAG GCCAATTCTA CCCTACTGAA CTCAAATTTG AGTTAATGAT GACCTCATTT TGATTGCTGC TGTAAAAAAT AAGATTTCGG AAGAGGAATG AATTCTTGTA TTACTGTGGT AGGACTATGG GTTTTTTTTT GTTTGTTTGT TTGTTTTGAG ACGGAGTCTC ACCCTGTCAC CCAGGCTGGA GTGCAGTGGT GCGATCTCAG CTCACAGCAG CCAGGTTCAA GTGATTCTCC TTCCTCAGCC TCCCGAGTAG CTGAGATTAC AGGCACGTGC CACCATGCCC GGCTAATTTT TTGTATCTTT AGTAGAGATG GTTTCACCAT GTTGGCCAGG CTGGTCTCGA ACTCCTGACC TCGTGATCCG CCTGCCTCAG CCTCCCAAAG TGCTGGGACT ACAGGCGTGA GCCACCGTGC CCGGCCGGGT TATTCATTTT TCTTATTAAC ATTCTTTGAT GATTCTTATG GTGTTGTTAC AGTAAAACAT TTCTAACAAT TATTCTAACA ATTATTCTTG ATGGTGTATA TGAAGAATTT ATTGTCGTGT ATTTGTAAGC TGCTATGTGC AGAAGAATTT CAGTCAAATA AAGTTGGTAA GATAGGTATG TAAGTAATAT GAAAAAAGAT AGAAGGTGAT GAGTGACTTA GGTATAAATT AAGTACAATA GAAATGTTGA GGAAAGAAAA ATTTCTTGTA ATAGAAATCG GAAGTACAAA CTGGGCATGG TGGTGTGCAT CTCTAATCCC AGCTCCTTGA GAGGCTGGTA TGGGAGGATC ACTTTAGCCC AGGAGCTTGA GGCTGCAGTG AGGTGTGATC ATGTCACCGC ACTCCATCCT GGGTGACAGC AAGACCGTCT CTCTTTTTTT TTTTTTTTGA GACGGAGTCT CGCCTATGCT GGAGTGCAAT GGCGCGATCT TGGCTCACTG CAACCTCTGC CTCCCAGTTT CAAGTGATTC TCCTGCCTCA GCCTCCTGAG CAGCTGGGAT TACAGGTGTG CGCCACCATG CCCAGCTAAT TATTTTGTAT TTTAAGTAGA GACGGGTTCT CACCATACTG GCCAGGCTGG TCTTCAACTC CTGACCTCTT GTTCGCCCAT CTAGGTCTCC CAAAGTGCTG GGATTACAGG TGTGAGCCAC CCCACTTGGC CCCGAGCGAG ACCCTCTCTC TAAAAAAAAA TAAATAAATA AATCATAAAC CTGTGGATTA TTGTAGCATT GTTTCTCATC TGTCAAAAAT ATTTCATGAC TATGCATAGT TTGAAAAGGC AAGTTTGTCC CTGGGCAATT TTCAAAATAT TTCTTTAATG TGTTTTCACA ATACTGTTTA CCTAATAAAT CTTAAGTTTT TAAAAGCAAA ATTAAGCCAG TAATTTGAGT CCAATTCCAA TCTCTTATGA GTCATTGCTT AAATTTCAAA AGGGTTTTAT TTTTTTTTTA GGTTTGTTCT GAGTAATGAA TACCCTATTA CTATGATACT AGTATCTTCC TTAATTATCC TACTCATTGT CTCAACATTC TGACAGTTGG ATTGAGCATA TTCGTAAGTA AAATTGTTTT AACTGTATGA TGTACTTTGA TGTTAAGGTC CGAGTCCCCA CATACCTCGG TAGATGTGTT CTTACAGTTT TGTATTCCCT TGAAATGTAA CTGTTCTCTA TGTTACAGCC TTTATAACCT TCAGTTACTT GAAATGAACA AATTCATTCA AATTCCAGCA bfl-109 72

CTTAAAAGTT TTAAATTACA TTTTGGATAA ATACCAAAGT GTTTTGTTGA TGATGTATGT ATAAACAAAT TGTAAATATT AAACGTTAGT TGTTACGATT AGACCTATAT AAAACATGAT ATGCAGTCTA CTGAATAGCT ATCAGCCTCT AACATGTTTA GTGTCATTTA GAAAATGCTT TCTAAATTGC CAAAAGCTGA TTGTCTAGGT GATAACAAAT TTACCATTTG GAGGAAGTTG ACTTTCTCAT TTTCATGTCT TCATCAGTCT TACTTGATGA GATTCATTCT TCTAGTCAGA AGAGAGTTTA GACTGCTCAG TTTACTCATA TTTTGAGTTA GCTTTTCTAT TTAGAGTTCA CTTGGTTGTG GAATATTCAT TTATAATTTG AATCTACGTT GTGTAATGGG ACCTAATTTT TTTTTCCTTT GTTTTTGTTG GAGTCTCGTT TTGTCACCCA GGTTGGAGTG CAGTGGCGTG ATCTTTGCTC ACTGCAACCT CCACCTTCCA GGTTCAGGTG ATTCTCCTGC CTCAGTCTCC CAAGTAGCTG GGATTACAGG CATGCTTCAC CACGCCTGGC TAATTTTTGT ATTTTTAGTA GAGATGGGGT TTCACCATGT TGGCCAGGCT GGTCTCAAAA CTCCTGAGCT CAAGTGATCC TCCTGCCTTG GCCTCCATAA GTGCTGGGAT TACAGGCGTG AGCCGCTGAG CCTGGCCCCA GAGTTTGTTT TGTTTTGTTT TCAAGACAAG ATCTCACTCT ATTGCCCAGG CTGGAGAGCA GTAGTGCGAT CATAGCTCAC TGCAGCCTGA ACTCCTGGGT TCAAGCTATT CTCCTGCCTC CATCTTCTAA AGTGCTGTGA TTACAGGTCT GAGCCATGAT GCTTGGCCTG TGTTTTTGTT TGTTTGTTTT GGGGGACAGG GTCTTGCTTT GTCACCAAAA CTGGAGTGTA GTGGTGCGAA CATAGCTAGC TCACTGCAGC CTCCATCTCC CACGCTCAAG CAATCCTCTC ACCTCAGCCT TCCAAGTAGC TGAGACCGCA GGTGCGTGCT ACCATGCGTG GCTAATTTTC TATTTATATA TTTATTTTTT GGTAGACATG AGGTCTTGTC ATGTTTCCCA GGTGGTCTTT AACTCCTGGG CTCAGACAGT CCTCCCGCCT CAGCCACCCA AAGTGTTGGG ATTACAGGCG TGAGCCACCA TGCGTGGCAT AATTTTTTTT AAGTAAATTA TTTTTTTATC TTGAGTATAG AAGTGATTCA TGTTCATTGT GGAAAATATG AAACATATAG AAAAACAGAA AAGATTACAA AACATCTAAT CTGAAATGGT TAAGATTTTG ATGAGAACAG TCTCATCTCA TTTCCGTATA TTCCTGCCAG CCTATCCATC ATTCTTCGTA CATGTTTATC TACATTAAAA TTGGTGTTAT ATTTTGGAAA CTTTTTGTTT AACTACATTG TGAACATTTT TCATGTTTTA AAATGTCATT TTAATGATGG CAGATCCTAT TCAATAGATG TACACACACC TATTTAACTG GTCCACAATT GTTGGATATG TAGGTCGTTT CCTTTCTCTC TTTTTTTTTT TTTTTGGCTA CTACTTAATA GTTTCTCTGT ATAGAATGTG GTATTTTGAA AGTGTATCAA GCTTTAGATT GGTAGTATTC TTGCATTTAA TAAAGGGCAG TGGCCTTTGT TGACTGACAT GACAATATTT TTATAAAATT TGTTATTTGC TTTACAGAAA TTTTGAAAAT TATTGTAGAA ATGTTTTTAC CTCATATGAA CCACCTGACA TTGGAACAGA CTTTCTTTTC ACAAGTGTTA CCAAAGGTAT AATACTATTA CCTGAAAATA CATGTTATAA GGAATCTAGC CTCAGTCTTA GATGATTTAT TATTAATTAT GGCTCTCTTT TTCTAATATA TCAAATATAT TCAAAATAAA AATAAGGAGT AAGTAGATCT CATGTGAGAC TATAATGGTG TTAGTGTGAT CATTAGGCAG TTAAAAACTG TTACAGGCTG GGCACGGTGG CTCATGCCTG TAATCCCAGC TCTCTGAGAG GCTGAGGTGG GCAGATCATC TGAGGTCAGG AGTTCGAGAC CACCCATGGT CAACATGATG AAACCTCGTC TCTACTAAAA GTACAAAAAA TTAGCTGGAC ATGGTGGCAG GTGCCTGTAA TCCCAGCTAC TTGGGAGACT GAGACAGGAG AATTGCTTGA GCCTGGGAGG CGGAGGTTGC ATTGAGTCAA GATCGTGCCA TTGCACTCCA GCCTGGGCAA TAAGAGCGAT GCTCCGTCTC AAAAAAAAAA AAAAAAAAAA AAGAACTTAT ATTTTCAGAT TGTGTGGTTC CTTTACTAAC TGAATTTAAA TTATTTGTAG TCAATTTTAA ATGCTCTTGT ATTTTAAAGC CACTGTACTC CAGCCTGGGT GACAGAGTGA AACCCTTAAT TCAAAAAAAA AAAAAAAAAA AAGAAAAGCT GGAATATTGG CAAAATCAAG TAACTAAGAG AAAACATTAA ATTCACAGAA TACATTATTA CATTTTAGAT ATATATGGTA TATGTTTTCT CTGAAAAGCA CAAGCATACC TTTTTTGTTT TAAATGGAGG GAACTAAAGA TACTTTGGTG CCAAAATGAA ACATTATTTG TAATTAATCT CTTATTGAAA TGGGTTTCTA ACTTTAGCTT TGAATCGTAA TCTTTCAAAT TTCTTGTACT CATAGTCACT TGATGATTCT CTATCTGAAA TATTTCTTAG AATTTGTTCT TGACCACCAG AAAAAGATTC AACTGTTACA TAGATGAAAA TGGATGTTGA GTGTTAACAG GCCTATGGGA AACAGTATTT TCTTTAGCTA CATTGTATTG TTGACTGTGT TGCTATTCTT ATAATGTTTA GGTCATTTAA ATTGTTAGAA AGATCCAAGT ATTAAGATCT AGGGTGGCTA ACTTTTCACA GACAAAAAGC TTGTTTGTAA GGTCATTTAC TATACCCTTA ATTCAGGAAG GTTAGCTTGA ATTGGGTCAA AAGGAAACTG GTTAGAAAAT AAGTGAGTAG TGAATAGGCG ATTCAGTGCA AATTCCTTCC AGAAAATACC CTTGTAAATG ACTGTATGAA TGTGGATTCT TCAAGACAGT CAAATTTATT GTGCGAAAGT AATACTTTTA TTTTTTGCAT CTCTAAAACA TGAACTTTGA GTGATTTTTT AAAAAAATTG ATGCTATTAA ATAGATTCAA ACCATAGAAA TGGAAAATAA ATTTCTGTTT GGGGCTTTTG GGGGGATTAT GTTGTAAAAA TACCTTTTCT CTGTATTTTG TGCTTAATTA GGTACAATTG TTAAGCTAGA TGATAGCCTG TGGATGTTAC TAGTGCAAAA TCAAATTATC GTATTGTGTT TTCTCTGTAA AGTTTTGTCT TGTCTTTTCT AGTGATTTCT CTTATTCCTG TTTATTACTT GATTTGTTTT TACAGACTGT GAAATTATTC GATGACATGA TGTATGAATT AACCAGTCAA GCCAGAGGAC TGTCAAGCCA AAATTTGGAA ATCCAGACCA CTCTAAGGAA TATTTTACAA GTAAGTCAAA TGTATTAGAA AGCAGGAGAG AGAGGGAGCT TAAAGAATGT CAAAATTTTT ATACTGATAC TGATTAGCTA TGTATTCTTA TGTAATGGCC TAATGTTGGA ATTAAATTTA TAGAATTAAA GACGTGAATA TAGAAACATG AATTCTGAAT AATAAACTCT TATAAGAAGA GAAGTCATCA AGCTAGCTGA CCCTACCTGT ATTTTCAAGG ATATGTGTGG AACACCTGCC ATGTGTTTTG AAGTTTGTGT TAGTATTCTA AATGGCTAGA CAGTTGTTCC AGTATTTGTA GTTCTGATAG ACTAAAGTTC TGTGAAAAGA GGAAGAGACT GTGTTTTGTT CATTGCTGTA TTTGTAGCAC CCAGCATGCT GACTAATACC TTTTCAGTGC ACAAAAAATA TATTCTAAGT GAAATTTCCT TCCTTATTCA CAGACAATGG TGCAGCTCTT AGGAGCTCTC ACAGGATGTG TTCAGCATAT CTGTGCCACA CAGGAATCCA TCATTTTGGA AAATATTCAG AGTCTCCCCT CCTCAGTCCT TCATATAATT AAAAGCACAT TTGTGCATTG TAAGGTGAGT AAAGGTCTAA TTATACTTTG AATGGTATAT AATCAATGTG CATAGGGGCT GAGTAAAATA ATGTTTGTAT AAGATTTTAC ATTTTAGTCT ATATTATTGA AATAAACTTT TCCATAGAAT AAAGAACATG TAAGTAAATA ATTGTTGCAA AAAAAGTGGT TTTAAGGAAG TCATTAAAAG TGGCTTTTTG GGGTTTTTTA GTTTTATCTT ATTTCCCCTC TATAAAGAAA GAAGTTTTAA GAATTTGTGT TGAGACAGAC ACAGGGATCC TGAAATAGTT ATGTCATGTT GCATTGACCA ATATTCAATT ACCATTATGA TTAGATGTCA GAACTTCCTT TTATAAAGGA AAGTTAATCC TTATTTAGTC CATCTCTACA TGCCAGAGGT AGCCTTGAGG CACAAAAGCT TGCCTAGAAT TTATGGGTCA CAGACAGTTT TAATATTGCT ATTTGTTGGG CGAATGAAAA TCACTAGTTA ATTAATACCT CTCTTTGCTG ATAGGATGCT AAAAATGTCA CGCACCTGGC CTAATGTTAC CCTTTTTTAG TTCTGTATTT GCAAGATCAT GGAAGTCAGA AATAATATTT TATACATGCT TGCATCTCTT GAAGCACACT ATATTTAATG GATGTTCACT AAACAATGAA TGAATATGTG ATTCAGTAAA TTTATGATCT CTAATAGTAT GAATTAAAGT AAATTTGGCT CTTGAGCTTT GATTTGTTTT TTCTCTCATT TTTATTTATC CGTAATCAGA ATAGTGAATC TGTGTATTCT GGGTGTTTAC ACCTAGTTTC AGACCTTCTC CAGGCTCTTT TCAAGGAGGC CTATTCTCTT CAAAAGCAGT TAATGGAACT GCTGGACATG GTTTGCATGG ACCCTTTAGT AGATGACAAT GATGATATTT TGAATATGGT AATAGGTGAG TGAAGAAAAC TTTCTGCTTA GTATATGGTG ACTATAAATC ATGTATCAAT TAAAATTGTC TCTAATGATT CATGTTATTT TCTTACTAAT TATGCATTAA AATTGATTTA AATCTTACCA AATAAATTTT TAATCTTGAA ATTTGGAATT TGTAAAATTT ATTTTGGGTA CCTTAACCTA GATTTGCGTA TTTAGTTACT GTAATTTCTC CACAATGATT AACTTATATA ACTTTATAAT CTCTGAGGTT GTCCATATTC AGAGACAATA ACTTTCACAT TTTTTTAACC ATAACTGATA TTGAGATGCA GTTTATATTT CCTTCCAGAA TACATATAAA TACGTGCATA TGTGTATGTA AATATGTCTA TTCTCATATA CATATTATAA TGAAATAACT CATTTTACAT EPI-109 73

GTGATGCACT TTATACTAGT TTATTTTTAT TTTATTTTAT TTTTTTGAGA CAGAGTCTCA CTGTGTAGCC CAGGCTGGAG TGCAGTGGCA CAATCTCGGC TCACTGCAAC CTCGCCTCCC GGACTCAAGC GATTCTCCTG CCTCAGCCTC ATGAGTAGCT GGGATTATAG GCGTCCGCCA CCACACCTGG CTAATTTTTG TATTTTTAGT AGAGACAGGG TTTCACCGTG TTGGCCAGGC TGGTCTTGAA CTCCTGACCT CAGGTAATCC ACCTGCCTCA GCCTCCCAAA GTGCTGGGAT TACAGGCATG AGCCACCGTG CCCAGCCAAT ACTAGTTTAT TTTTAAAGAA TTGCTGGTCG TAACACACTT CATTGATTTT ATCACTCATT AATGGATTAT GAACAAGAGT TTGAAAAACA ATATAAAGGC AAAGTTTGCA TTCAAAACTT TGGTATAAAG AGAGTAAGTT GGTTTTGTGC AGTGTATCAG GCACCTGTTG CTCTGCAACA CACCACCTCA AAATCTATTT ATTCACTATT TATTTATTCA TGATTCTGTG AGTCTGCAGT TTAGGGTGGG ATGTCCTGAG ACAACTTTCT CTGATCCACC TGGGGCACTA GCTCACCCAT GTGACTTCAG TGACTTCATT CACATCTGGC TGTTGGCAGA GGCAGAAGTA CTTGAGAAAG CCATGTGCAT CATCCAGCAG GTTCACCCTA TCTCAGATAC CTGATGCCAG TGGTTTCAGG GTTTCTAAGA GTAGCAAAAG TGTGAGCAGG TCGCTGTGTG CTAGCACTTT TCAAGTTTCT GCTTGCCTTA ATTTTATTAT TGTCCCCCGG GCCACAGCAG GTCATAGCGT TTAGCCCAGA GTCATTGTAG AAAAGTGTGG ATTCACAAAG GGCAGTCATT GTGGCCATTT TTATAAATAA TCTACCACAG ACTGAGTAAA AGCCTTGCAT GAATACCATG GATATTAATT TGAATTCTTC CTTTTTAGAT TTTCTTTCCT TAGCAATTTG TTTTGTCATT TTGGATTAGA ATTATATCTG TAGAATATTT CAGTTATAAT AGGGTACAAC TTTTATTCCA CTGAACATCT TTAGTTTTAT TTAGGTCATC TGGTAGGTAT AAACTTCAGA AGTTAATATT CAATATTTAT AAAAACCATT AACAAGTGTG ACACTTAAAT AGTTTAAATA ATTCTTTTGA CACAACTGTT TCCAAGTTGT GTTACGTATT TTAATTCAAT CAAATGTTGA AATTGTTCAG TAGATAGTTT TAATTATAGG AGAAACTCAC CCCCATGACA TTTGGATGTC TTAAAAGTTC TGTTATCTTT CTTTGCAGTT ATTCATTCTT TATTGGATAT CTGCTCTGTT ATTTCCAGTA TGGACCATGC ATTTCATGCC AATACTTGGA AGTTTATAAT TAAGTAAGTT TGTTTGTTAT TTTTTACTTT TTAGAAAATG TTTTCCATAT TCCCCAATCT TAATTATTCA TGATTCTTTA GATTGCATTT AAAACATTTT GTGTGAATTT AATGTTCACT GACACTGCTG TCTGATAATC CAGATATTCT ACATGTAGCT CTCAAGCCAA ATTGGACTTC TTTACCCTGT GGCCTCTAAA ATTAAAAAAA ATGTTCTTCC TAGTTAGCTA GTACTTCAGA AATAATGGGC CATGGGCCAG ACTAGAACTT AACCACTTTT CTTCTGCTAC TGTTGTTTAA CCAGCTATCA AGTATCCTAT TTCTAGGATT AGATAAATTG ATAACTATAA TTAAAACTGA ATATAATCTT TTCATTAGGT ACTTTTAAGT TGTTCACACT TAATTCCATT TGTACAGTAA TTTTAACTTT CTGAAACTGA AGCATTTTAA AGGGTCACCA GGGATAGTGC CTGTAGCATT CATCAGATTC TTAGGGGTGA GAGGAGATGT GGTTGAGATG TAAAAATGGT TAAGAATATC TACTTTATAC ACATACATAA AACATTAAAG GTCAGTGTAT TTTCAGGTCT TAGGTACTTT TCTTGTACTA CCAGGACATT AAGTTGCCAT TCAGTGGTTA AGAGTGTTGC CTGGGAGCTG TATCACATGT GCTTAAATCC ATTCTTGAAA TCATTTACTC CTTCTGAGCC CTTGGGCTAT TTGGTTAATT TCTCTGAACG TTAGTTTGCT CATCTGAAAA TGGAAATAAT AATAGCAACT TCTTGACAGG GTTATAGTGA GAATTGAGTT CATCACTGTG AAATGCTTAG AAATGTGCAT GACACATAGT TAATACTCAA GGAATTAGCC ACATCACTAT CATCATCACT GATTATCTTC CACTCTTACC CTCTTCCAGT TCATTTTCTG CCCAGCAGAA TGATCTTTTA AAAAGTAAAT CAGATCATGT TACTCTATTG CTTGAAGTCT ATCCCATTTG ATTAAGAATA ACAACCTAAT CCTCTGTGGA TGCTGCCTCC TTCACCAGCC TGTCTCATGC TGCTCTCCCT ACTCTTAGTT CCTCAAACAT ACCAAACTCT CCTGTCCCAG AGTCTTTTCG TGGTTTTTCC ATCTGCCTAG GATGCTTCTC TCTCCTATTT TGTGTACCTT GCTAACTCCT GCTTACTGTC TTTCAGTTCT CAGCTTAAGA GTTATATCTT CATGATAACA TTCTTTGATA TCCTTACCCT AAGATTAAGT TAGATTGATA TCCTTACCCT AAGAATAAGT TAGATTAGGT CTCTCTATTG TAGCACCTTA GACTCTGTCA TTTGACAAAT CACAGCCCTA ATTAATTATT CTTAAAATTA TTTAACATTC TCTCTCATGC TAGACCACAA GTTTCATGCA GGTAAGGCGG AGATTGTGTC CATTTGTTTG ACCCCTTTGT CTCCAGGGCC TGGTAGAATG CCTCATACAT AGTAAGAATT CAATTAATAT TTTACACAGA GAAAAAATTA GCAACTTATT TAAACAAATA TAACTGCTTC AGAGGTAAAC TGGGCACATC TTAGTTATAT TATGTGATAT ATGATGCTTT TTGATTGTTT TTTTAAATGT TCTACAAGGT AGATATTGTT AGAGGTCCTA AGTTACTTGA TGTGTTACTT GTGGTGATTG TATTCTTTTC TTTTTATTCA TTTAGGCAGA GCCTTAAGCA CCAGTCCATA ATAAAAAGCC AGTTGAAACA CAAAGATATA ATTACTAGCT TGTGTGAAGA CATTCTTTTC TCCTTCCATT CTTGTTTACA GTTAGCTGAG CAGATGACAC AGTCAGATGC ACAGGTAAAA TTTGGGCTAA TAGCATTTTA AACAGCAACT CTTATTTTCT TTGGCAGTTA GTAAATCTCA TTTGAATGTC TGGGTCAGTC TATTTAAGAG GATTTTAATT TATTTCATTT GGGTGTTTTT TTTTGATCTG TGGGATTATT TATATCCCAT AATTACTTTT CACCCAGAGC ATTGTATTAG ATTCCTAACT GCTGTCATTG CCTCTGGGGT CTGCCTGGCT CCCTCTTTGC TTGGTAACTG GTTGGTCACA GCATTCTTCT CAGAATCCTT TCATTCTTTT CTGCATGAGA ACAAAAATTC TTTTGTTCAT ATTTGTATAA GATCTGATAT AGCTGCAATC AATCTTGCAT TTTTTCTTCA CCAACGCATT GCGACCTTTA GGGATACAAG TATGTTTGTG CATGTATATG TATGTATCAG TCTTTTAAAT TTGATATAGT CATACATTTG TTTTTATTTT GAAAAGTTAG AGTGTTGAAT TGGTATCCCA TTTATGAAAC ATTATATTCT AAAAATTTGT AGTACGATTA TTGGGAATTA TAACTCATTT TCCTGTAACA CTGTTATACA TAGTACCTTT TGCTTTCAGA CTAGCCCTCA ATTTTATTTA ACTATAGTAG TCCTAAATTA TAAGATTAAT AGTACTCAGG ACCTAACAGT TATATGTCAT TTGTTTTTTT TTTTTTTGAG ATGGCGTCTC ACTCTGTCAC CCAAGCTGGA GTGCAGTGGT ATGACCTTGG CTCACTGCAG CCTCTGCCTC ACGGGTTCAA GGGATCGTTC TGCCTTAGCC TCCTGAGTAG CTGGGATTAT AGGCGCCTGC CACCACGCCT GGCTAATTTT TTTAGTAGAG ACGGGGTTTC GCCATGTTGG CCAGGCTGGT CTCGAACTCC TGACCTCAGG TGGTCCACCC GCCTTGGCCT CCCAAAGTGC TGGGATTACA GGTGTGAGCC ACCGCGCCCA GCCTATATGT AATAATTTTA ATGGGACCAT GAATTGAATA TTTCTTCCTT GAATAGCAAT GACATAGCCC CTTCTATTGT ACATCTGCAA GCTGATACAG GGAATTCCTT TGTACCTGCG CTCTTCCCTG CCAGTCAGCT ATGGGGGTGA AAGTGTAGGG GTTCATCCAA GTCCTAAAAC TGGTAGCAAC TCCTAGGGCA GGGCTGATCT GGAAGGACAG ACCCTAGGGG AGGGTGGAAC TTTAAAAAGA AGTTCTGAAG GTAGTAAGAA GGAAATGAGG AGTAGTGTTA GGAAGGGGCT AACTTTTTTC TTCTTGCTTC TCTTCTTTAT CTCACCTGCC CCTCCCCTTG TATCCCTTCT TCCTTTTTCC CTTTCCTTTT TTGTCCTCAC TTCATTCGTG CATCCTTTCT GATTCCTCTT ACCTTGCTAA AAGGAGAAGT TTGTTTGGGT ATCCTATATC AATGGCAGGA AGGTTGTTTT CTTCTTTACC TTTATCCTAT AGATTCATAT TCTCAACACC AACCTCCTCC TTTTTCAGTT TCCTTCTTGC TTCTCTTGAC ACCACAGAGT TTGCAGCTAG TACTTGGAGA GGAAAATTAA ACAGAGATAC TTGGACCAAG AGTAAGATGA AGAAAGTCTA AACAACAGTA TAGTCTATAG TGGCAAGAGA GAGTATGGGG GCTGCTTAGC CAGGGTGGCT GTACATAAAG TATATCTTCA GTTTATATAA ACTGCTTATA GATGGAAATC AGAAAATTTA AATTCTCTTA ACTGTCCAAG AAAATTCTCA TTTTTTCAAA TTTGGGACTG ATAAATGTGA CCAGTTCTGC TTACTGTCCA TTGCCTGAAA TGGAGCTTTG AGGTGGACTG TATAATTTCT TCAATCTTAA CTCCAAATTC TGATCAGCGA CGCCCTCTGC TGTTCACTAT TAATATTTAT TTACCAATCA AAGTAAAGTA TTGAAGTTTT CCTGGCAGTT TTCACTTTGT GTTTTAGTCC ATTTAGGCTG CTATAACAAA ATCCCTTAAA CTGGGTAAGG GATTATAAAT ATTAGAAATT TATCTCTCAC AGTTCTGGAA GCTGGGAAGC CCAATATCAA GGCACCAGTA GATTTGGTGT CTAACGAGGG TGTGCCGTCT GCTTCAAAAA TGGCCCCTTG TTGCTGCATC CTCACTTAGT GCAAGGGGCA AGACAGCTCC CTTCAACCTC TTTTATAAGG GCACTTATGT CATTCATGAG GGCAGAGCCC TCATGACTTA ATCACTTCCC CAAAGGCCCC EPI-109 74

ACCTCTTAAT AGTATCACAT TGGGTGTTAG GTGTCTGGGA GGACACCAAT CTTCAAGCCA TATCATCTCA CTTGGAAAAA AGTCAAAATA AAACCAGTAG ATTTAATTAA TATTACACTA TTTATAGAAG CATGTGATGT ATCATTCCTT GTATTAATTT CCTGGGGTTG CCGTAACAAG TTACCACAAA CTAGGTGGCT TAAAACAATA GAATTTTATT CTCTCACATT TCTAGAGGCA GAAGTTCACA GTGTGTCAAT AGGGCCATGT TCTCTGGAAG GCTTTAGGGG AGAATATATT TCATATCTTT CTCTTAGCTT CTCGGTGTCA CTGGCAATCC TTAGCTTACT TTGGCTTTCT GTGTCTTCAC ATCATCTTTT TATAAGAACA CCAGTGATAG TGATTAAGGG CATACCTTAC TTTAATATGA CCTCATCTTA ACTAATTATG TCTTCAATAA CCCTATTTCC AAATAAGGCC ACATTCTGAA GTATTGGGAG TTAGAACTTA AAGCTTTTTG GGAGGGACAC AGTTCAACCC ATAACAACCC CTAAAATCGA TATTTATTCT CAATTAAGTC TTGAAATTGG TTTCAAAAAG AGAATATTCT ATTAGAGTTT TTAATGTATA GTTTTAACAT ATAGTTCTTT AGCCCCCAAT TTTTTTTTTT TTTTTTTTTT TTTTTTTTTT TTTTTGAGAC GGAGTCTCGC TCTGTCGCCC AGGCCGGACT GCGGACTGCA GTGGCGCAAT CTCGGCTCAC TGCAAGCTCC GCTTCCCGGG TTCACGCCAT TCCCCTGCCT CAGCCTCCCG AGTAGCTGGG ACTACAGGCG CCTGCCACCG CGCCCGGCTA ATTTTTTTGT ATTTTTAGTA GAGACGGGGT TTCACCTTGT TAGCCAGGAT GGTCTCGATC TCCTGACCTC ATGATCCACC CGCCTCGGCC TCCCAAAGTG CTGGGATTAC AGGCGTGAGC CACCGCGCCC GGCCTGCCCC CAATTATTTA GTTTTTCTAT AAACAGGGAA ATTTATTTGT GTGGCCCTTA GAACTAATTT AATTTCCACT CTAATTCCTA CTTATGTTTA TATAATGCTT TTAGAAATTT GTATTATTCA GAAAATAAAC ATATACTATT GTATCTGTTG CCTACACTTA GATTTTATTG CCTGCTATAT TTAAATTTTA TTAGTATTTT AATTGTTTTA TTAAAGAAAG AATGTGCCTG TAATCTCAGC ACTTTTGAGA GGCCAAGGCA GAAGGATTGC TTGAGCCCAG GAGTTTGAGA CCAGACTGAG CAACACAGGG AGACCCCCAT CTCTACAAAA AATAAAAAAA TTCTCCAGGC CTCATGGCAC ATACCTGTAG TTCTAGTTAC TTGGGAGACT GGGGTGGGAG GATGCATTGA GCCCAGGAGA TTGAGGCTGC AGTGAGCCAT GATCAGGCCA CTGTACTCCA GCTTGGACAA CAGAGTGAGA GCTTGTCTAG ATAGATAGAT AGATAGATAA TCTAAATAGA TAATAGACAG ATTATCTAAA TAGATAATAG ACAGATTATC TAAATAGATA ATAGACAGAT TATCTAAATA GATAATAGAC AGATTATCTA AATAGATAAT AGACAGATTA TCTAAATAGA TAATAGACAG ATTATCTATC TAAATAGATA ATAGATTATC TAAATAGATA ATAGATAGAT AGATTAGATA GATAGATAGA TAGATAGAGC TTGGACAACA GAGTGAGAGC CTGTCTAGAT AGATAGAAAC AAAGAAAGAA AGAAAGAATG GTGCTCATAT TTTAAAGCAT TGAAAAATGG TCTTCCTTGC TTATATTACC CACACCTTCT TTGTTGGCAT TAAGATGCAA ACTTTGTTTT AAACAGTTGA GTAAATCAAA GATGGGACTG TTAAGTTATT TGTGTTATTT ACCTGCTTTT TGAAAATGTA AAAATAAAAC TCTAGGTTTA ATTAGTAGTA TGCTATTTAG TAATGAAGTA AAGCTAGAGG CTTCGAACAA ATCTTGTGTA ATTTCCTCTT GAATGAGAGA GAAAATTTAA AGTAAGCAAA CAAATAAGTT GTGTGTCACC ACTCATTCAG TCATTTAACA AGTATTTCCA GAGTACTTAT TCTGTGCCAG GAAATGTTGT AGGTGCCCTC AACAACTTAG AGTCTAGCCT GAGACACAAG TAAGTAGGTA ATTATTATAG AATGGTATGA TCTTTGGAGG ACTGGGTATT GGCTGGCTCA TGGGAGTACA AGATAGGTAC CCAGTGATGA AGTCAGGAAA GGTTTCTTAT GGTGATATGA TGACGTCTAT GCTGATTATA AGGTCAGTGT AGAATAAACT TTGTGCTTTT AAATTTGCAT AGCACTGTAT TAGAGAGTTC ATCTTCAAAA TAATCGAAAA GGCTGAGTGT GGTGACCCAT GGCTGTAATC CCAGCACTTT GGGAGGCCGA GGTGGGCAGA TTGCTTGAGC TAGGAGTTCG AGACCAGGCT GGCCAACATG GTGAAACCCC GTCTCTACTA AAAATACAAA AATTAGCCAG GAGTGATGGT GCGCACCTGT AATGCCAGCT ACTTGGGAGG CTGAGGCAGG AGGATCACTT GAACCCAGGA GGTGGAGGTT GAAGTAAGCC GAGGTCATGC CACTGCACTC CAGCCTGGGC AACAGAGTGA GACTCCATCT CAAAAAAAAA AAAAATGATC AAAGAAAGGT GAATTTTCAT CTACCCTATT TCTGCTGAGG AAAATGGACT ATTTTCAAAT ATTTTTAATA AGGGTCAAAA TGAGGGATC GCATTTTTTC AAGTTTTATG ATTTATTTAA CTTGTGGAAC AAAAATAAAC CAGAAACCAC CACCTCTCAC GCCAAAGCTC ACACCTTCAG CCTCCAACAT GAAGGTCTCC GCAGCACTTC TGTGGCTGCT GCTCATAGCA GCTGCCTTCA GCCCCCAGGG GCTCGCTGGG CCAGCTTCTG TCCCAACCAC CTGCTGCTTT AACCTGGCCA ATAGGAAGAT ACCCCTTCAG CGACTAGAGA GCTACAGGAG AATCACCAGT GGCAAATGTC CCCAGAAAGC TGTGATCTTC AAGACCAAAC TGGCCAAGGA TATCTGTGCC GACCCCAAGA AGAAGTGGGT GCAGGATTCC ATGAAGTATC TGGACCAAAA ATCTCCAACT CCAAAGCCAT AAATAATCAC CATTTTTGAA ACCAAACCAG AGCCTGAGTG TTGCCTAATT TGTTTTCCCT TCTTACAATG CATTCTGAGG TAACCTCATT ATCAGTCCAA AGGGCATGGG TTTTATTATA TATATATATA TTTTTTTTTT AAAAAAAAAC GTATTGCATT TAATTTATTG AGGCTTTAAA ACTTATCCTC CATGAATATC AGTTATTTTT AAACTGTAAA GCTTTGTGCA GATTCTTTAC CCCCTGGGAG CCCCAATTCG ATCCCCTGTC ACGTGTGGGC AATGTTCCCC CTCTCCTCTC TTCCTCCCTG GAATCTTGTA AAGGTCCTGG CAAAGATGAT CAGTATGAAA ATGTCATTGT TCTTGTGAAC CCAAAGTGTG ACTCATTAAA TGGAAGTAAA TGTTGTTTTA GGAATAC ATGAAGGTCT CCGCAGCACT TCTGTGGCTG CTGCTCATAG CAGCTGCCTT CAGCCCCCAG GGGCTCGCTG GGCCAGCTTC TGTCCCAACC ACCTGCTGCT TTAACCTGGC CAATAGGAAG ATACCCCTTC AGCGACTAGA GAGCTACAGG AGAATCACCA GTGGCAAATG TCCCCAGAAA GCTGTGATCT TCAAGACCAA ACTGGCCAAG GATATCTGTG CCGACCCCAA GAAGAAGTGG GTGCAGGATT CCATGAAGTA TCTGGACCAA AAATCTCCAA CTCCAAAGCC ATAA CCACATATTC CCCTCCTTTT

CCAAGGCAAG ATCCAGATGG ATTAAAAAAT GTACCAAGTC CCTCCTACTA GCTTGCCTCT CTTCTGTTCT GCTTGACTTC CTAGGATCTG GAATCTGGTC AGCAATCAGG AATCCCTTCA TCGTGACCCC CGCATGGGCA AAGGCTTCCC TGGAATCTCC CACACTGTCT GCTCCCTATA AAAGGCAGGC AGATGGGCCA GAGGAGCAGA GAGGCTGAGA CCAACCCAGA AACCACCACC TCTCACGCCA AAGCTCACAC CTTCAGCCTC CAACATGAAG GTCTCCGCAG CACTTCTGTG GCTGCTGCTC ATAGCAGCTG CCTTCAGCCC CCAGGGGCTC GCTGGGCCAG GTAAGCCCCC CAACTCCTTA CAGGAAAGGT AAGGTAACCA CCTCCAGGCT ACTAGGTCAG CAAGAATCTT TACAGACTCA CTGCAAATTC TCCATTTGAA AAATAGGGAA ACAGGTTTTG TGGGTGGACA AGAAATGCCT CAACCGTCAC ATCCAGTCAC TGGAAGAGCC AGAACTAGAA AGCTCCCGAG TCTTTTCCCC ACATTCAAGA GGGCCGCTGG GTGCATCCTT ACCCAGCTAT CCTTACAGTG TTTGGGAATG GGGAATGGCT CTGTCTTACT GTGGGCATGG TGGGCATTTT TGGCAGTGGG AGAGAAGGAA AATCTGTTGA TTAGAAGCTC AGTATGTTAA TTCGACTCCA GGACAGCTTT CAGAGACAGT GGCTAAGAGA AGAACGAGGT CCCAGGGGAT CTCTTGAGGT GACTTATTTT GACACTCTTT GGGAAAGTTA TCTAGGAGAT TTGTTCCATA ACTCATTTTC CCATACTCTG GTGACAAATT TACTGAGTGT ATCGGTCCCA CTGAGCCAGT GCATAGCATG GTAACAAACA GTTCTAAATT ATCAATGACT TAACAGAATT AACTAAATTA ACAAAAGTTA CTTTCTCACT TGTACTAAAT ATCTATAATG TATGGGCTCA GGCTTCTGCA TTTTATACTC AGGATTCTAG ACTGATGGAG AAGTTGCCAT GTGGGGGAAC ATTGATGGAT ACTGTGATAA AGCAGAAGAA AGCTCTCAGG AGTCTTGCAT AGGCAATGCA CTGTGGCTCA AAAATGACAC CCATCACTTT GTCTCCTTCT TTATTGATCA AAACTAATTA ATGCCTCCAA CCAAACAAAA GTGGCCAAGA AATGCAAGTC TACCTTGTGT CTCAAAACAG AGGATGGAGA ATATTTGGTG AAAATTACCA TGACCATCAC ATGGCCACGT AGGTCTTTAT AATGACAGAG CTAGCATTTG TCACATTGAC CAAGCTTTGT CCATACACTC TACAGTAATG ATGAGTCCTC AGTGCACAGG GGAGGATGCT GAAGACACAG GACAGCATCC TCCAGACACA TAAGACTTCA GAGCAGAGGG ATTCTCCCTC CACCTCTCGC AATTCCTTGC TTTCTCCTAA CTTCCTTTAC AAAGTCATGC TTGGAAATGT CTATGTATCA TCATGTGGCT CATTTTTTTC TCTGTTCATT TTTTTTCCCC AAAATTCAGC TTCTGTCCCA ACCACCTGCT GCTTTAACCT GGCCAATAGG bPl-109 75

AAGATACCCC TTCAGCGACT AGAGAGCTAC AGGAGAATCA CCAGTGGCAA ATGTCCCCAG AAAGCTGTGA TGTAAGTAAA TAAAGTTCAC CCTCCCCTAG ACAAAAAAAT AATGTCTAGG GCACAGAGTC AAGAACTGTG GGAGTCATAG ACTCTGATAG TTTGACCTCT ATGGTCCAAT TCATTAATTT TCACAAGTGA GTGTTCACTC CCAGCTCCCT GCCTGGGAGA TTGCTGTAGT CATATCAATT TCTTCAAGTC AAGAGCAAAG ATGGTTTTAC TGGGCCTTTA AGAGCAGCAA CTAACCCAAG AGTCTCATCC TTCCTCCTCT CCGTAGCAAC CCTTTGTCCA GGGGCAGATG GTCCTTAAAT ATTTAGGGTC AAATGGGCAG AATTTTCAAA AACAATCCTT CCAATTGCAT CCTGATTCTC CCCACAGCTT CAAGACCAAA CTGGCCAAGG ATATCTGTGC CGACCCCAAG AAGAAGTGGG TGCAGGATTC CATGAAGTAT CTGGACCAAA AATCTCCAAC TCCAAAGCCA TAAATAATCA CCATTTTTGA AACCAAACCA GAGCCTGAGT GTTGCCTAAT TTGTTTTCCC TTCTTACAAT GCATTCTGAG GTAACCTCAT TATCAGTCCA AAGGGCATGG GTTTTATTAT ATATATATAT ATATATTTTT TTTTAAAAAA AAACGTATTG CATTTAATTT ATTGAGGCTT TAAAACTTAT CCTCCATGAA TATCAGTTAT TTTTAAACTG TAAAGCTTTG TGCAGATTCT TTACCCCCTG GGAGCCCCAA TTCGATCCCC TGTCACGTGT GGGCAATGTT CCCCCTCTCC TCTCTTCCTC CCTGGAATCT TGTAAAGGTC CTGGCAAAGA TGATCAGTAT GAAAATGTCA TTGTTCTTGT GAACCCAAAG TGTGACTCAT TAAATGGAAG TAATGTTGTT TTAGGAATAC ATAAAGTATG TGCATATTTT ATTATAGTCA CTAGTTGTAA TTTTTTTGTG GGAAATCCAC ACTGAGCTGA GGGGG GCCAGGTCGC TGTTGGTCCA CGCCGCCCGT CGCGCCGCCC GCCCGCTCAG CGTCCGCCGC CGCCATGGGA GGCCGGAGCC GAGCCGGGGT CGGGCAGCAG CAGGGACCCC CCAGAGGCGG GGCCTGTGGG ACCGCTATGG GCGTGGAGAT CGAGACCATC TCCCCCGGAG ACGGAAGGAC ATTCCCCAAG AAGGGCCAAA CGTGTGTGGT GCACTACACA GGAATGCTCC AAAATGGGAA GAAGTTTGAT TCATCCAGAG ACAGAAACAA ACCTTTCAAG TTCAGAATTG GCAAACAGGA AGTCATCAAA GGTTTTGAAG AGGGTGCAGC CCAGATGAGC TTGGGGCAGA GGGCGAAGCT GACCTGCACC CCTGATGTGG CATATGGAGC CACGGGCCAC CCCGGTGTCA TCCCTCCCAA TGCCACCCTC ATCTTTGACG TGGAGCTGCT CAACTTAGAG TGAAGGCAGG AAGGAACTCA AGGTGGCTGG AGATGGCTGC TGCTCACCCT CCTAGCCTGC TCTGCCACTG GGACGGCTCC TGCTTTTGGG GCTCTTGATC AGTGTGCTAA CCTCACTGCC TCATGGCATC ATCCATTCTC TCTGCCCAAG TTGCTCTGTA TGTGTTCGTC AGTGTTCATG CGAATTCTTG CTTGAGGAAA CTTCGGTTGC AGATTGAAGC ATTTCAGGTT GTGCATTTTG TGTGATGCAT GTAGTAGCCT TTCCTGATGA CAGAACACAG ATCTCTTGTT CGCACAATCT ACACTGCCTT ACCTTCACTT AAACCACACA CACAAGGTGC TCAGACATGA AATGTACATG GCGTACCGTA CACAGAGGGA CTTGAGCCAG TTACCTTTGC TGTCACTTTC TCTCTTATAA ATTCTGTTAG CTGCTCACTT AAACAATGTC CTCTTTGAGA AAATGTAAAA TAAAGGCTCT GTGCTTGACA GAATTCGGGC CGCCGCCAGG TCGCTGTTGG TCCACGCCGC CCGTCGCGCC GCCCGCCCGC TCAGCGTCCG CCGCCGCCAT GGGAGTGCAG GTGGAAACCA TCTCCCCAGG AGACGGGCGC ACCTTCCCCA AGCGCGGCCA GACCTGCGTG GTGCACTACA CCGGGATGCT TGAAGATGGA AAGAAATTTG ATTCCTCCCG GGACAGAAAC AAGCCCTTTA AGTTTATGCT AGGCAAGCAG GAGGTGATCC GAGGCTGGGA AGAAGGGGTT GCCCAGATGA GTGTGGGTCA GAGAGCCAAA CTGACTATAT CTCCAGATTA TGCCTATGGT GCCACTGGGC ACCCAGGCAT CATCCCACCA CATGCCACTC TCGTCTTCGA TGTGGAGCTT CTAAAACTGG AATGACAGGA ATGGCCTCCT CCCTTAGCTC CCTGTTCTTG GATCTGCCAT GGAGGGATCT GGTGCCTCCA GACATGTGCA CATGAGTCCA TATGGAGCTT TTCCTGATGT TCCACTCCAC TTTGTATAGA CATCTGCCCT GACTGAATGT GTTCTGTCAC TCAGCTTTGC TTCCGACACC TCTGTTTCCT CTTCCCCTTT CTCCTCGTAT GTGTGTTTAC CTAAACTATA TGCCATAAAC CTCAAGTTAT TCATTTTATT TTGTTTTCAT TTTGGGGTGA AGATTCAGTT TCAGTCTTTT GGATATAGGT TTCCAATTAA GTACATGGTC AAGTATTAAC AGCACAAGTG GTAGGTTAAC ATTAGAATAG GAATTGGTGT TGGGGGGGGG GTTTGCAAGA ATATTTTATT TTAATTTTTT GGATGAAATT TTTATCTATT ATATATTAAA CATTCTTGCT GCTGCGCTGC AAAGCCATAG CAGATTTGAG GCGCTGTTGA GGACTGAATT ACTCTCCAAG TTGAGAGATG TCTTTGGGTT AAATTAAAAG CCCTACCTAA AACTGAGGTG GGGATGGGGA GAGCCTTTGC CTCCACCATT CCCACCCACC CTCCCCTTAA ACCCTCTGCC TTTGAAAGTA GATCATGTTC ACTGCAATGC TGGACACTAC AGGTATCTGT CCCTGGGCCA GCAGGGACCT CTGAAGCCTT CTTTGTGGCC TTTTTTTTTT TTCATCCTGT GGTTTTTCTA ATGGACTTTC AGGAATTTTG TAATCTCATA ACTTTCCAAG CTCCACCACT TCCTAAATCT TAAGAACTTT AATTGACAGT TTCAATTGAA GGTGCTGTTT GTAGACTTAA CACCCAGTGA AAGCCCAGCC ATCATGACAA ATCCTTGAAT GTTCTCTTAA GAAAATGATG CTGGTCATCG CAGCTTCAGC ATCTCCTGTT TTTTGATGCT TGGCTCCCTC TGCTGATCTC AGTTTCCTGG CTTTTCCTCC CTCAGCCCCT TCTCACCCCT TTGCTGTCCT GTGTAGTGAT TTGGTGAGAA ATCGTTGCTG CACCCTTCCC CCAGCACCAT TTATGAGTCT CAAGTTTTAT TATTGCAATA AAAGTGCTTT ATGCCCGAAT TC GCCGCCGCCA TGGGAGTGCA GGTGGAAACC ATCTCCCCAG GAGACGGGCG CACCTTCCCC AAGCGCGGCC AGACCTGCGT GGTGCACTAC ACCGGGATGC TTGAAGATGG AAAGAAATTT GATTCCTCCC GGGACAGAAA CAAGCCCTTT AAGTTTATGC TAGGCAAGCA GGAGGTGATC CGAGGCTGGG AAGAAGGGGT TGCCCAGATG AGTGTGGGTC AGAGAGCCAA ACTGACTATA TCTCCAGATT ATGCCTATGG TGCCACTGGG CACCCAGGCA TCATCCCACC ACATGCCACT CTCGTCTTCG ATGTGGAGCT TCTAAAACTG GAATGACAGG AATGGCCTCC TCCCTTAGCT CCCTGTTCTT GGATCTGCCR TGGAGGGATC TGGTGCCTCC AGACATGTGC ACATGARTCC ATATGGAGCT TTTCCTGATG TTCCACTCCA CTTTGTATAG ACATCTGCCC TGACTGAATG TGTTCTGTCA CTCAGCTTTG CTTCCGACAC CTCTGTTTCC TCTTCCCCTT TCTCCTCGTA TGTGTGTTTA CCTAAACTAT ATGCCATAAA CCTCAAGTTA TTCA AAGCTTCTAC CCTAGTCTGG TGCTACACTT ACATTGCTTA CATCCAAGTG

TGGTTATTTC TGTGGCTCCT GTTATAACTA TTATAGCACC AGGTCTATGA CCAGGAGAAT TAGACTGGCA TTAAATCAGA ATAAGAGATT TTGCACCTGC AATAGACCTT ATGACACCTA ACCAACCCCA TTATTTACAA TTAAACAGGA ACAGAGGGAA TACTTTATCC AACTCACACA AGCTGTTTTC CTCCCAGATC CATGCTTTTT TGCGTTTATT ATTTTTTAGA GATGGGGGCT TCACTATGTT GCCCACACTG GACTAAAACT CTGGGCCTCA AGTGATTGTC CTGCCTCAGC CTCCTGAATA GCTGGGACTA CAGGGGCATG CCATCACACC TAGTTCATTT CCTCTATTTA AAATATACAT GGCTTAAACT CCAACTGGGA ACCCAAAACA TTCATTTGCT AAGAGTCTGG TGTTCTACCA CCTGAACTAG GCTGGCCACA GGAATTATAA AAGCTGAGAA ATTCTTTAAT AATAGTAACC AGGCAACATC ATTGAAGGCT CATATGTAAA AATCCATGCC TTCCTTTCTC CCAATCTCCA TTCCCAAACT TAGCCACTGG TTCTGGCTGA GGCCTTACGC ATACCTCCCG GGGCTTGCAC ACACCTTCTT CTACAGAAGA CACACCTTGG GCATATCCTA CAGAAGACCA GGCTTCTCTC TGGTCCTTGG TAGAGGGCTA CTTTACTGTA ACAGGGCCAG GGTGGAGAGT TCTCTCCTGA AGCTCCATCC CCTCTATAGG AAATGTGTTG ACAATATTCA GAAGAGTAAG AGGATCAAGA CTTCTTTGTG CTCAAATACC ACTGTTCTCT TCTCTACCCT GCCCTAACCA GGAGCTTGTC ACCCCAAACT CTGAGGTGAT TTATGCCTTA ATCAAGCAAA CTTCCCTCTT CAGAAAAGAT GGCTCATTTT CCCTCAAAAG TTGCCAGGAG CTGCCAAGTA TTCTGCCAAT TCACCCTGGA GCACAATCAA CAAATTCAGC CAGAACACAA CTACAGCTAC TATTAGAACT ATTATTATTA ATAAATTCCT CTCCAAATCT AGCCCCTTGA CTTCGGATTT CACGATTTCT CCCTTCCTCC TAGAAACTTG ATAAGTTTCC CGCGCTTCCC TTTTTCTAAG ACTACATGTT TGTCATCTTA TAAAGCAAAG GGGTGAATAA ATGAACCAAA TCAATAACTT CTGGAATATC TGCAAACAAC AATAATATCA GCTATGCCAT CTTTCACTAT TTTAGCCAGT ATCGAGTTGA ATGAACATAG AAAAATACAA AACTGAATTC TTCCCTGTAA ATTCCCCGTT TTGACGACGC ACTTGTAGCC ACGTAGCCAC GCCTACTTAA GACAATTACA EPI-109 76

AAAGGCGAAG AAGACTGACT CAGGCTTAAG CTGCCAGCCA GAGAGGGAGT CATTTCATTG GCGTTTGAGT CAGCAAAGGT ATTGTCCTCA CATCTCTGGC TATTAAAGTA TTTTCTGTTG TTGTTTTTCT CTTTGGCTGT TTTCTCTCAC ATTGCCTTCT CTAAAGCTAC AGTCTCTCCT TTCTTTTCTT GTCCCTCCCT GGTTTGGTAT GTGACCTAGA ATTACAGTCA GATTTCAGAA AATGATTCTC TCATTTTGCT GATAAGGACT GATTCGTTTT ACTGAGGGAC GGCAGAACTA GTTTCCTATG AGGGCATGGG TGAATACAAC TGAGGCTTCT CATGGGAGGG AATCTCTACT ATCCAAAATT ATTAGGAGAA AATTGAAAAT TTCCAACTCT GTCTCTCTCT TACCTCTGTG TAAGGCAAAT ACCTTATTCT TGTGGTGTTT TTGTAACCTC TTCAAACTTT CATTGATTGA ATGCCTGTTC TGGCAATACA TTAGGTTGGG CACATAAGGA ATACCAACAT AAATAAAACA TTCTAAAAGA AGTTTACGAT CTAATAAAGG AGACAGGTAC ATAGCAAACT AATTCAAAGG AGCTAGAAGA TGGAGAAAAT GCTGAATGTG GACTAAGTCA TTCAACAAAG TTTTCAGGAA GCACAAAGAG GAGGGGCTCC CCTCACAGAT ATCTGGATTA GAGGCTGGCT GAGCTGATGG TGGCTGGTGT TCTCTGTTGC AGAAGTCAAG ATGGCCAAAG TTCCAGACAT GTTTGAAGAC CTGAAGAACT GTTACAGGTA AGGAATAAGA TTTATCTCTT GTGATTTAAT GAGGGTTTCA AGGCTCACCA GAATCCAGCT AGGCATAACA GTGGCCAGCA TGGGGGCAGG CCGGCAGAGG TTGTAGAGAT GTGTACTAGT CCTGAAGTCA GAGCAGGTTC AGAGAAGACC CAGAAAAACT AAGCATTCAG CATGTTAAAC TGAGATTACA TTGGCAGGGA GACCGCCATT TTAGAAAAAT TATTTTTGAG GTCTGCTGAG CCCTACATGA ATATCAGCAT CAACTTAGAC ACAGCCTCTG TTGAGATCAC ATGCCCTGAT ATAAGAATGG GTTTTACTGG TCCATTCTCA GGAAAACTTG ATCTCATTCA GGAACAGGAA ATGGCTCCAC AGCAAGCTGG GCATGTGAAC TCACATATGC AGGCAAATCT CACTCAGATG TAGAAGAAAG GTAAATGAAC ACAAAGATAA AATTACGGAA CATATTAAAC TAACATGATG TTTCCATTAT CTGTAGTAAA TACTAACACA AACTAGGCTG TCAAAATTTT GCCTGGATAT TTTACTAAGT ATAAATTATG AAATCTGTTT TAGTGAATAC ATGAAAGTAA TGTGTAACAT ATAATCTATT TGGTTAAAAT AAAAAGGAAG TGCTTCAAAA CCTTTCTTTT CTCTAAAGGA GCTTAACATT CTTCCCTGAA CTTCAATTAA AGCTCTTCAA TTTGTTAGCC AAGTCCAATT TTTACAGATA AAGCACAGGT AAAGCTCAAA GCCTGTCTTG ATGACTACTA ATTCCAGATT AGTAAGATAT GAATTACTCT ACCTATGTGT ATGTGTAGAA GTCCTTAAAT TTCAAAGATG ACAGTAATGG CCATGTGTAT GTGTGTGACC CACAACTATC ATGGTCATTA AAGTACATTG GCCAGAGACC ACATGAAATA ACAACAATTA CATTCTCATC ATCTTATTTT GACAGTGAAA ATGAAGAAGA CAGTTCCTCC ATTGATCATC TGTCTCTGAA TCAGGTAAGC AAATGACTGT AATTCTCATG GGACTGCTAT TCTTACACAG TGGTTTCTTC ATCCAAAGAG AACAGCAATG ACTTGAATCT TAAATACTTT TGTTTTACCC TCACTAGAGA TCCAGAGACC TGTCTTTCAT TATAAGTGAG ACCAGCTGCC TCTCTAAACT AATAGTTGAT GTGCATTGGC TTCTCCCAGA ACAGAGCAGA ACTATCCCAA ATCCCTGAGA ACTGGAGTCT CCTGGGGCAG GCTTCATCAG GATGTTAGTT ATGCCATCCT GAGAAAGCCC CGCAGGCCGC TTCACCAGGT GTCTGTCTCC TAACGTGATG TGTTGTGGTT GTCTTCTCTG ACACCAGCAT CAGAGGTTAG AGAAAGTCTC CAAACATGAA GCTGAGAGAG AGGAAGCAAG CCAGCTGAAA GTGAGAAGTC TACAGCCACT CATCAATCTG TGTTATTGTG TTTGGAGACC ACAAATAGAC ACTATAAGTA CTGCCTAGTA TGTCTTCAGT ACTGGCTTTA AAAGCTGTCC CCAAAGGAGT ATTTCTAAAA TATTTTGAGC ATTGTTAAGC AGATTTTTAA CCTCCTGAGA GGGAACTAAT TGGAAAGCTA CCACTCACTA CAATCATTGT TAACCTATTT AGTTACAACA TCTCATTTTT GAGCATGCAA ATAAATGAAA AAGTCTTCCT AAAAAAATCA TCTTTTTATC CTGGAAGGAG GAAGGAAGGT GAGACAAAAG GGAGAGAGGG AGGGAAGCCT AATGAAACAC CAGTTACCTA AGACCAGAAT GGAGATCCTC CTCACTACCT CTGTTGAATA CAGCACCTAC TGAAAGAACT TTCATTCCCT GACCATGAAC AGCCTCTCAG CTTCTGTTTT CCTTCCTCAC AGAAATCCTT CTATCATGTA AGCTATGGCC CACTCCATGA AGGCTGCATG GATCAATCTG TGTCTCTGAG TATCTCTGAA ACCTCTAAAA CATCCAAGCT TACCTTCAAG GAGAGCATGG TGGTAGTAGC AACCAACGGG AAGGTTCTGA AGAAGAGACG GTTGAGTTTA AGCCAATCCA TCACTGATGA TGACCTGGAG GCCATCGCCA ATGACTCAGA GGAAGGTAAG GGGTCAAGCA CAATAATATC TTTCTTTTAC AGTTTTAAGC AAGTAGGGAC AGTAGAATTT AGGGGAAAAT TAAACGTGGA GTCAGAATAA CAAGAAGACA ACCAAGCATT AGTCTGGTAA CTATACAGAG GAAAATTAAT TTTTATCCTT CTCCAGGAGG GAGAAATGAG CAGTGGCCTG AATCGAGAAT ACTTGCTCAC AGCCATTATT TCTTAGCCAT ATTGTAAAGG TCGTGTGACT TTTAGCCTTT CAGGAGAAAG CAGTAATAAG ACCACTTACG AGCTATGTTC CTCTCATACT AACTATGCCT CCTTGGTCAT GTTACATAAT CTTTTCGTGA TTCAGTTTCC TCTACTGTAA AATGGAGATA ATCAGAATCC CCCACTCATT GGATTGTTGT AAAGATTAAG AGTCTCAGGC TTTACAGACT GAGCTAGCTG GGCCCTCCTG ACTGTTATAA AGATTAAATG AGTCAACATC CCCTAACTTC TGGACTAGAA TAATGTCTGG TACAAAGTAA GCACCCAATA AATGTTAGCT ATTACTATCA TTATTATTAT TATTTTATTT TTΠTTTTTG AGATGGAGTC TGGCTCTGTC ACCCAGGCTG GAGTGCAGTG GCACAATCTC GGCTCACTGC AAGCTCTGCC TCCTGGGTTC ATGCCATTCT CCTGCCTCAG CCTCCCGAGT AAGCTGGGAA TACAGGCACC CGCCACTGTT CCCGGCTAAT TTTTTGTATT TTTAGTAGAG ACGGAGTTTC ACCGTGGTCT CCATCTCCTC GTGATCCACC CACCTTGGCC TCCCAAAGTG CCGGGATTAC AGGCGTGAGC CACCGCGCCC GGCCTATTAT TATTATTATT ACTACTACTA CTACCTATAT GAATACTACC AGCAATACTA ATTTATTAAT GACTGGATTA TGTCTAAACC TCACAAGAAT CCTACCTTCT CATTTTACAT AAAAGGAAAC TAAGCTCATT GAGATAGGTA AACTGCCCAA TGGCATACAT CTGTAAGTGG GAGAGCCTCA AATCTAATTC AGTTCTACCT GAGTAAAAAA ATCATGGTTT CTCCTCCATC CCTTTACTGT ACAAGCCTCC ACATGAACTA TAAACCCAAT ATTCCTGTTT TTAAGATAAT ACCTAAGCAA TAACGCATGT TCACCTAGAA GGTTTTAAAA TGTAACAAAA TATAAGAAAA TAAAAATCAC TCATATCGTC AGTGAGAGTT TACTACTGCC AGCACTATGG TATGTTTCCT TAAAATCTTT GCTATACACA TACCTACATG TGAACAAATA TGTCTAACAT CAAGACCACA CTATTTACAA CTTTATATCC AGCTTTTCTT ACTTAGCAAT GTATTGAGGA CATTTTAGAG TGCCCGTTTT TCACCATTAT AAGCAATGCA ACAATGAACA TCTGTATAAA TAAATATTCA TTTCTCTCAC CCTTTATTTC CTTAGAATAT ATTCCTAGAA GTAGAATTTC CCAGAGCCAT GAGGATTTGT GACGCTATTG ATATGTGCCA CTTTGCACTC TCTGTGACAT ATATAATTAT TTTTAATGCA TTCATTTTTT TCTCAGAGTG CATTCGTTTG AAAACATAGA CGGGAAATAC TGGTAGTCTT CCTTGTCAGT TAGAAACACC CAAACAATGA AAAATGAAAA AGTTGCACAA ATAGTCTCTA AAAACAATGA AACTATTGCC TGAGGAATTG AAGTTTAAAA AGAAGCACAT AAGCAACAAC AAGGATAATC CTAGAAAACC AGTTCTGCTG ACTGGGTGAT TTCACTTCTC TTTGCTTCCT CATCTGGATT GGAATATTCC TAATACCCCC TCCAGAACTA TTTTCCCTGT TTGTACTAGA CTGTGTATAT CATCTGTGTT TGTACATAGA CATTAATCTG CACTTGTGAT CATGGTTTTA GAAATCATCA AGCCTAGGTC ATCACCTTTT AGCTTCCTGA GCAATGTGAA ATACAACTTT ATGAGGATCA TCAAATACGA ATTCATCCTG AATGACGCCC TCAATCAAAG TATAATTCGA GCCAATGATC AGTACCTCAC GGCTGCTGCA TTACATAATC TGGATGAAGC AGGTACATTA AAATGGCACC AGACATTTCT GTCATCCTCC CCTCCTTTCA TTTACTTATT TATTTATTTC AATCTTTCTG CTTGCAAAAA ACATACCTCT TCAGAGTTCT GGGTTGCACA ATTCTTCCAG AATAGCTTGA AGCACAGCAC CCCCATAAAA ATCCCAAGCC AGGGCAGAAG GTTCAACTAA ATCTGGAAGT TCCACAAGAG AGAAGTTTCC TATCTTTGAG AGTAAAGGGT TGTGCACAAA GCTAGCTGAT GTACTACCTC TTTGGTTCTT TCAGACATTC TTACCCTCAA TTTTAAAACT GAGGAAACTG TCAGACATAT TAAATGATTT ACTCAGATTT ACCCAGAAGC CAATGAAGAA CAATCACTCT CCTTTAAAAA GTCTGTTGAT CAAACTCACA AGTAACACCA AACCAGGAAG ATCTTTATTA TCTCTGATAA CATATTTGTG AGGCAAAACC TCCAATAAGC TACAAATATG GCTTAAAGGA EPI-109 77

TGAAGTTTAG TGTCCAAAAA CTTTTATCAC ACACATCCAA TTTTCATGGC GGACATGTTT TAGTTTCAAC AGTATACATA TTTTCAAAGG TCCAGAGAGG CAATTTTGCA ATAAACAAGC AAGACTTTTT CTGATTGGAT GCACTTCAGC TAACATGCTT TCAACTCTAC ATTTACAAAT TATTTTGTGT TCTATTTTTC TACTTAATAT TATTTCTGCA ATTTTCCCAA TATTGACATC GTGTATGTAT TTGCCATTTT TAATATCACT AGACAATTCA ATCAGGTTGC TACGTTGGTC CCTTGGGTTT ACTCTAAATA GCTTGATTGC AAATATCTTT GTATATATTA TTGTTTTTTC TCCTATCTTG TAATTTCTTT GAGCACATCC CAAAGAGGAA TGCCTAGATC AATGGGCACA AATAATTTGA CAGCTCTTAT TAAACATTAT TCTGTAAGTA AAAACTGAAC TACTTTTCAG TATCACTAGC AACATATGAG TGTATCAGCT TCCTAAACCC CTCCATGTTA GGTCATTATG AACTTATGAT CTAACAAATT ACAGGGTCTT ATCCCACTAA TGAAATTATA AGAGATTCAA CACTTATTCA GCCCCGAAGG ATTCATTCAA CGTAGAAAAT TCTAAGAACA TTAACCAAGT ATTTACCTGC CTAGTGAGTG TGGAAGACAT TGTGAAGGAC ACAAAGATGT ATAGAATTCC ATTCCTGACT TCCAGGTATT TACACCATAG GTGGGGACCT AACTACACAC ACACACACAC ACACACACAC ACACACACAC ACCATGCACA CACAATCTAC ATCAACACTT GATTTTATAC AAATACAATG AATTTACTTT CTTTTTGGTT CTTCTCTTCA CCAGTGAAAT TTGACATGGG TGCTTATAAG TCATCAAAGG ATGATGCTAA AATTACCGTG ATTCTAAGAA TCTCAAAAAC TCAATTGTAT GTGACTGCCC AAGATGAAGA CCAACCAGTG CTGCTGAAGG TCAGTTGTCC TTTGTCTCCA ACTTACCTTC ATTTACATCT CATATGTTTG TAAATAAGCC CAATAGGCAG ACACCTCTAA CAAGGTGACA CTGTCCTCTT TCCTTCCTAC CACAGCCCCC ACCTACCCAC CCCACTCCCA TTGATTCCAG AGGCGTGCCT AGGCAGGATC TATGAGAAAA TATAACAGAG AGTAAGAGGA AAATTACCTT CTTTCTTTTT CCTTTCCCTG CCTGACCTTA TTCACCTCCC ATCCCAGAGC ATCCATTTAT TCCATTGATC TTTACTGACA TCTATTATCT GACCTACACA ATACTAGACA TTAGGACAAT GTGGCCTGCC TCCAAGAAAC TCAAATAAGC CAACTGAGAT CAGAGAGGAT TAATCACCTG CCAATGGGCA CAAAGCAACA AGCTGGGAGC CAAGTCCCAA AATGGGGCCT GCTGCTTCCA GTTCCCCTCT CTCTGCATTG ATGTCAGCAT TATCCTTCGT CCCAGTCCTG TCTCCACTAC CACTTTCCCC CTCAAACACA CACACACACA ACAGCCTTAG ATGTTTTCTC CACTGATAAG TAGGTGACTC AATTTGTAAG TATATAATCC AAGACCTTCT ATTCCCAAGT AGAATTTATG TGCCTGCCTG TGCTTTTCTA CCTGGATCAA GTGATGTCTA CAGAGTAGGG CAGTAGCTTC ATTCATGAAC TCATTCAACA AGCATTATTC ACTGAGAGCC TTGTATTTTT CAGGCATAGT GCCAACAGCA GTGTGGACAG TGGTGCATCA AAGCCTCTAG TCTCATAGAA CTTAGTCTTC TGGAGGATAT GGAAAACAGA CAACCCAAAC AACCAACAAA AGAGCAAGAT GCTGCAAAAA AAAAAAAAAT GAATAGGGTG CTAAGATAGA GAAAAGTGGG AGAGTGCTAT TTAGACAAAG TGGTAAAAAC AAAGCCCCTT GTGAGATGAG AGCTGCCGAC AGAGGGGGCG GGTCATGGTT GTGGGTTTTT GGGTAGGACA TTCAGAGGAG GGGGCGGGTC GTGGTTGTGG GTTTTTGGGT AGGACATTCA GAGGAGGGGG CGGGTCGTGG TTGTGGGTTT TTGGGTAGGA CATTCAGAGG AGGGGGCGGG TCGTGGTTGT GGGTTTTTGG GTAGGACATT CAGAGGAGGG GGCGGGTCGT GGTTGTGGGT TTTTGGGACA TTCAGAGGAG TCTGAATGCA CCCAGGCCTA CAACTTCAAG ATGGTAAAGG ACAGCTCCAA GGATCAGAAG AAGCATTCTT GGAACTGGGG CATTTTGAGA AGGAGGAAAA ATATGCAGAG ACTAGTGCTT GCAGAGCTTG CATTTGGATT TCATTTGAGG TACAATGAAA ACCCATTAAT GGGTTTCACA CAGTGCAATG GCCTGACCTC ACTTATATTT CCTAAAATAG AAAACAGATC AGAAGGAAGG CAATAGAGAA GCAGAAAGTC CAATGAGGAG GTTTCACAGC AGTCATGGGG GTGGGGTAAG GAAAAGAAGT GGAAAGAAAC AGACAGAATT GGGTTATATT TTGGAGATAG AACCAACAGA AGGAAGAGGA GAAACAACAT TTACTGAGAA GGGAAAAAGT AGGAGAGGAA TAGGTTTGGG AAATAAATCC TGCTGACATT GGAAACCCCA AGGAAGCCTC AAAAGTATAT TTACTTGCTT TAGATTTAAA AGAATAGGAA AGAAGCATCT CAACTTGGAA TTTGAAATCT ATTTTTCCAT AAAAGTATTG TTAAATTCTA CTCATACTCA CAAGAAAAGT ACATTCTAAA GAGTATATTG AAAGAGTTTA CTGATATACT TAGGAATTTT GTGTGTATGT GTGTGTGTGT ATGTGTGTGT GTGTGTTTAA CCTTCAATTG TTGACTTAAA TACTGAGATA AATGTCATCT AAATGCTAAA TTGATTTCCC AAAGGTATGA TTTGTTCACT TGGAGATCAA AATGTTTAGG GGGCTTAGAA TCACTGTAGT GCTCAGATTT GATGCAAAAT GTCTTAGGCC TATGTTGAAG GCAGGACAGA AACAATGTTT CCCTCCTACC TGCCTGGATA CAGTAAGATA CTAGTGTCAC TGACAATCTT CATAACTAAT TTAGATCTCT CTCCAATCAA CTAAGGAAAT CAACTCTTAT TAATAGACTG GGCCACACAT CTACTAGGCA TGTAATAAAT GCTTGCTGAA TGAACAAATG AATGAAGAGC CTATAGCATC ATGTTACAGC CATAGTCCTA AAGTGGTGTT TCTCATGAAG GCCAAATGCT AAGGGATTGA GCTTCAGTCC TTTTTCTAAC ATCTTGTTCT CTAACAGAAT TCTCTTCTTT TCTTCATAGG AGATGCCTGA GATACCCAAA ACCATCACAG GTAGTGAGAC CAACCTCCTC TTCTTCTGGG AAACTCACGG CACTAAGAAC TATTTCACAT CAGTTGCCCA TCCAAACTTG TTTATTGCCA CAAAGCAAGA CTACTGGGTG TGCTTGGCAG GGGGGCCACC CTCTATCACT GACTTTCAGA TACTGGAAAA CCAGGCGTAG GTCTGGAGTC TCACTTGTCT CACTTGTGCA GTGTTGACAG TTCATATGTA CCATGTACAT GAAGAAGCTA AATCCTTTAC TGTTAGTCAT TTGCTGAGCA TGTACTGAGC CTTGTAATTC TAAATGAATG TTTACACTCT TTGTAAGAGT GGAACCAACA CTAACATATA ATGTTGTTAT TTAAAGAACA CCCTATATTT TGCATAGTAC CAATCATTTT AATTATTATT CTTCATAACA ATTTTAGGAG GACCAGAGCT ACTGACTATG GCTACCAAAA AGACTCTACC CATATTACAG ATGGGCAAAT TAAGGCATAA GAAAACTAAG AAATATGCAC AATAGCAGTT GAAACAAGAA GCCACAGACC TAGGATTTCA TGATTTCATT TCAACTGTTT GCCTTCTGCT TTTAAGTTGC TGATGAACTC TTAATCAAAT AGCATAAGTT TCTGGGACCT CAGTTTTATC ATTTTCAAAA TGGAGGGAAT AATACCTAAG CCTTCCTGCC GCAACAGTTT TTTATGCTAA TCAGGGAGGT CATTTTGGTA AAATACTTCT CGAAGCCGAG CCTCAAGATG AAGGCAAAGC ACGAAATGTT ATTTTTTAAT TATTATTTAT ATATGTATTT ATAAATATAT TTAAGATAAT TATAATATAC TATATTTATG GGAACCCCTT CATCCTCTGA GTGTGACCAG GCATCCTCCA CAATAGCAGA CAGTGTTTTC TGGGATAAGT AAGTTTGATT TCATTAATAC AGGGCATTTT GGTCCAAGTT GTGCTTATCC CATAGCCAGG AAACTCTGCA TTCTAGTACT TGGGAGACCT GTAATCATAT AATAAATGTA CATTAATTAC CTTGAGCCAG TAATTGGTCC GATCTTTGAC TCTTTTGCCA TTAAACTTAC CTGGGCATTC TTGTTTCATT CAATTCCACC TGCAATCAAG TCCTACAAGC TAAAATTAGA TGAACTCAAC TTTGACAACC ATGAGACCAC TGTTATCAAA ACTTTCTTTT CTGGAATGTA ATCAATGTTT CTTCTAGGTT CTAAAAATTG TGATCAGACC ATAATGTTAC ATTATTATCA ACAATAGTGA TTGATAGAGT GTTATCAGTC ATAACTAAAT AAAGCTTGCA ACAAAATTCT CTGACACATA GTTATTCATT GCCTTAATCA TTATTTTACT GCATGGTAAT TAGGGACAAA TGGTAAATGT TTACATAAAT AATTGTATTT AGTGTTACTT TATAAAATCA AACCAAGATT TTATATTTTT TTCTCCTCTT TGTTAGCTGC CAGTATGCAT AAATGGCATT AAGAATGATA ATATTTCCGG GTTCACTTAA AGCTCATATT ACACATACAC AAAACATGTG TTCCCATCTT TATACAAACT CACACATACA GAGCTACATT AAAAACAACT AATAGGCCAG GCACGGTGGC TCAGACCTGT AATCCCAGCA CTTTGGGAGG ACCAACCTCT TCGAGGCACA AGGCACAACA GGCTGCTCTG GGATTCTCTT CAGCCAATCT TCATTGCTCA AGTGTCTGAA GCAGCCATGG CAGAAGTACC TGAGCTCGCC AGTGAAATGA TGGCTTATTA CAGTGGCAAT GAGGATGACT TGTTCTTTGA AGCTGATGGC CCTAAACAGA TGAAGTGCTC CTTCCAGGAC CTGGACCTCT GCCCTCTGGA TGGCGGCATC CAGCTACGAA TCTCCGACCA CCACTACAGC AAGGGCTTCA GGCAGGCCGC GTCAGTTGTT GTGGCCATGG ACAAGCTGAG GAAGATGCTG GTTCCCTGCC CACAGACCTT CCAGGAGAAT GACCTGAGCA CCTTCTTTCC CTTCATCTTT GAAGAAGAAC CTATCTTCTT CGACACATGG GATAACGAGG CTTATGTGCA CGATGCACCT GTACGATCAC TGAACTGCAC bfl-lU9 78

GCTCCGGGAC TCACAGCAAA AAAGCTTGGT GATGTCTGGT CCATATGAAC TGAAAGCTCT CCACCTCCAG GGACAGGATA TGGAGCAACA AGTGGTGTTC TCCATGTCCT TTGTACAAGG AGAAGAAAGT AATGACAAAA TACCTGTGGC CTTGGGCCTC AAGGAAAAGA ATCTGTACCT GTCCTGCGTG TTGAAAGATG ATAAGCCCAC TCTACAGCTG GAGAGTGTAG ATCCCAAAAA TTACCCAAAG AAGAAGATGG AAAAGCGATT TGTCTTCAAC AAGATAGAAA TCAATAACAA GCTGGAATTT GAGTCTGCCC AGTTCCCCAA CTGGTACATC AGCACCTCTC AAGCAGAAAA CATGCCCGTC TTCCTGGGAG GGACCAAAGG CGGCCAGGAT ATAACTGACT TCACCATGCA ATTTGTGTCT TCCTAAAGAG AGCTGTACCC AGAGAGTCCT GTGCTGAATG TGGACTCAAT CCCTAGGGCT GGCAGAAAGG GAACAGAAAG GTTTTTGAGT ACGGCTATAG CCTGGACTTT CCTGTTGTCT ACACCAATGC CCAACTGCCT GCCTTAGGGT AGTGCTAAGA GGATCTCCTG TCCATCAGCC AGGACAGTCA GCTCTCTCCT TTCAGGGCCA ATCCCCAGCC CTTTTGTTGA GCCAGGCCTC TCTCACCTCT CCTACTCACT TAAAGCCCGC CTGACAGAAA CCACGGCCAC ATTTGGTTCT AAGAAACCCT CTGTCATTCG CTCCCACATT CTGATGAGCA ACCGCTTCCC TATTTATTTA TTTATTTGTT TGTTTGTTTT ATTCATTGGT CTAATTTATT CAAAGGGGGC AAGAAGTAGC AGTGTCTGTA AAAGAGCCTA GTTTTTAATA GCTATGGAAT CAATTCAATT TGGACTGGTG TGCTCTCTTT AAATCAAGTC CTTTAATTAA GACTGAAAAT ATATAAGCTC AGATTATTTA AATGGGAATA TTTATAAATG AGCAAATATC ATACTGTTCA ATGGTTCTGA AATAAACTTC TCTGAAG AGAAAGAAAG AGAGAGAGAA AGAAAAGAAA GAGGAAGGAA GGAAGGAAGG AAGAAAGACA GGCTCTGAGG AAGGTGGCAG TTCCTACAAC GGGAGAACCA GTGGTTAATT TGCAAAGTGG ATCCTGTGGA GGCANNCAGA GGAGTCCCCT AGGCCACCCA GACAGGGCTT TTAGCTATCT GCAGGCCAGA CACCAAATTT CAGGAGGGCT CAGTGTTAGG AATGGATTAT GGCTTATCAA ATTCACAGGA AACTAACATG TTGAACAGCT TTTAGATTTC CTGTGGAAAA TATAACTTAC TAAAGATGGA GTTCTTGTGA CTGACTCCTG ATATCAAGAT ACTGGGAGCC AAATTAAAAA TCAGAAGGCT GCTTGGAGAG CAAGTCCATG AAATGCTCTT TTTCCCACAG TAGAACCTAT TTCCCTCGTG TCTCAAATAC TTGCACAGAG GCTCACTCCC TTGGATAATG CAGAGCGAGC ACGATACCTG GCACATACTA ATTTGAATAA AATGCTGTCA AATTCCCATT CACCCATTCA AGCAGCAAAC TCTATCTCAC CTGAATGTAC ATGCCAGGCA CTGTGCTAGA CTTGGCTCAA AAAGATTTCA GTTTCCTGGA GGAACCAGGA GGGCAAGGTT TCAACTCAGT GCTATAAGAA GTGTTACAGG CTGGACACGG TGGCTCACGC CTGTAATCCC AACATTTGGG AGGCCGAGGC GGGCAGATCA CAAGGTCAGG AGATCGAGAC CATCCTGGCT AACATGGTGA AACCCTGTCT CTACTAAAAA TACAAAAAAT TAGCCGGGCG TTGGCGGCAG GTGCCTGTAG TCCCAGCTGC TGGGGAGGCT GAGGCAGGAG AATGGTGTGA ACCCGGGAGG CGGAACTTGC AGGGGGCCGA GATCGTGCCA CTGCACTCCA GCCTGGGCGA CAGAGTGAGA CTCTGTCTCA AAAAAAAAAA AAAAGTGTTA TGATGCAGAC CTGTCAAAGA GGCAAAGGAG GGTGTTCCTA CACTCCAGGC ACTGTTCATA ACCTGGACTC TCATTCATTC TACAAATGGA GGGCTCCCCT GGGCAGATCC CTGGAGCAGG CACTTTGCTG GTGTCTCGGT TAAAGAGAAA CTGATAACTC TTGGTATTAC CAAGAGATAG AGTCTCAGAT GGATATTCTT ACAGAAACAA TATTCCCACT TTTCAGAGTT CACCAAAAAA TCATTTTAGG CAGAGCTCAT CTGGCATTGA TCTGGTTCAT CCATGAGATT GGCTAGGGTA ACAGCACCTG GTCTTGCAGG GTTGTGTGAG CTTATCTCCA GGGTTGCCCC AACTCCGTCA GGAGCCTGAA CCCTGCATAC CGTATGTTCT CTGCCCCAGC CAAGAAAGGT CAATTTTCTC CTCAGAGGCT CCTGCAATTG ACAGAGAGCT CCCGAGGCAG AGAACAGCAC CCAAGGTAGA GACCCACACC CTCAATACAG ACAGGGAGGG CTATTGGCCC TTCATTGTAC CCATTTATCC ATCTGTAAGT GGGAAGATTC CTAAACTTAA GTACAAAGAA GTGAATGAAG AAAAGTATGT GCATGTATAA ATCTGTGTGT CTTCCACTTT GTCCCACATA TACTAAATTT AAACATTCTT CTAACGTGGG AAAATCCAGT ATTTTAATGT GGACATCAAC TGCACAACGA TTGTCAGGAA AACAATGCAT ATTTGCATGG TGATACATTT GCAAAATGTG TCATAGTTTG CTACTCCTTG CCCTTCCATG AACCAGAGAA TTATCTCAGT TTATTAGTCC CCTCCCCTAA GAAGCTTCCA CCAATACTCT TTTCCCCTTT CCTTTAACTT GATTGTGAAA TCAGGTATTC AACAGAGAAA TTTCTCAGCC TCCTACTTCT GCTTTTGAAA GCTATAAAAA CAGCGAGGGA GAAACTGGCA GATACCAAAC CTCTTCGAGG CACAAGGCAC AACAGGCTGC TCTGGGATTC TCTTCAGCCA ATCTTCATTG CTCAAGTATG ACTTTAATCT TCCTTACAAC TAGGTGCTAA GGGAGTCTCT CTGTCTCTCT GCCTCTTTGT GTGTATGCAT ATTCTCTCTC TCTCTCTCTT TCTTTCTCTG TCTCTCCTCT CCTTCCTCTC TGCCTCCTCT CTCAGCTTTT TGCAAAAATG CCAGGTGTAA TATAATGCTT ATGACTCGGG AAATATTCTG GGAATGGATA CTGCTTATCT AACAGCTGAC ACCCTAAAGG TTAGTGTCAA AGCCTCTGCT CCAGCTCTCC TAGCCAATAC ATTGCTAGTT GGGGTTTGGT TTAGCAAATG CTTTTCTCTA GACCCAAAGG ACTTCTCTTT CACACATTCA TTCATTTACT CAGAGATCAT TTCTTTGCAT GACTGCCATG CACTGGATGC TGAGAGAAAT CACACATGAA CGTAGCCGTC ATGGGGAAGT CACTCATTTT CTCCTTTTTA CACAGGTGTC TGAAGCAGCC ATGGCAGAAG TACCTGAGCT CGCCAGTGAA ATGATGGCTT ATTACAGGTC AGTGGAGACG CTGAGACCAG TAACATGAGC AGGTCTCCTC TTTCAAGAGT AGAGTGTTAT CTGTGCTTGG AGACCAGATT TTTCCCCTAA ATTGCCTCTT TCAGTGGCAA ACAGGGTGCC AAGTAAATCT GATTTAAAGA CTACTTTCCC ATTACAAGTC CCTCCAGCCT TGGGACCTGG AGGCTATCCA GATGTGTTGT TGCAAGGGCT TCCTGCAGAG GCAAATGGGG AGAAAAGATT CCAAGCCCAC AATACAAGGA ATCCCTTTGC AAAGTGTGGC TTGGAGGGAG AGGGAGAGCT CAGATTTTAG CTGACTCTGC TGGGCTAGAG GTTAGGCCTC AAGATCCAAC AGGGAGCACC AGGGTGCCCA CCTGCCAGGC CTAGAATCTG CCTTCTGGAC TGTTCTGCGC ATATCACTGT GAAACTTGCC AGGTGTTTCA GGCAGCTTTG AGAGGCAGGC TGTTTGCAGT TTCTTATGAA CAGTCAAGTC TTGTACACAG GGAAGGAAAA ATAAACCTGT TTAGAAGACA TAATTGAGAC ATGTCCCTGT TTTTATTACA GTGGCAATGA GGATGACTTG TTCTTTGAAG CTGATGGCCC TAAACAGATG AAGGTAAGAC TATGGGTTTA ACTCCCAACC CAAGGAAGGG CTCTAACACA GGGAAAGCTC AAAGAAGGGA GTTCTGGGCC ACTTTGATGC CATGGTATTT TGTTTTAGAA AGACTTTAAC CTCTTCCAGT GAGACACAGG CTGCACCACT TGCTGACCTG GCCACTTGGT CATCATATCA CCACAGTCAC TCACTAACGT TGGTGGTGGT GGCCACACTT GGTGGTGACA GGGGAGGAGT AGTGATAATG TTCCCATTTC ATAGTAGGAA GACAACCAAG TCTTCAACAT AAATTTGATT ATCCTTTTAA GAGATGGATT CAGCCTATGC CAATCACTTG AGTTAAACTC TGAAACCAAG AGATGATCTT GAGAACTAAC ATATGTCTAC CCCTTTTGAG TAGAATAGTT TTTTGCTACC TGGGGTGAAG CTTATAACAA CAAGACATAG ATGATATAAA CAAAAAGATG AATTGAGACT TGAAAGAAAA CCATTCACTT GCTGTTTGAC CTTGACAAGT CATTTTACCC GCTTTGGACC TCATCTGAAA AATAAAGGGC TGAGCTGGAT GATCTCTGAG ATTCCAGCAT CCTGCAACCT CCAGTTCTGA AATATTTTCA GTTGTAGCTA AGGGCATTTG GGCAGCAAAT GGTCATTTTT CAGACTCATC CTTACAAAGA GCCATGTTAT ATTCCTGCTG TCCCTTCTGT TTTATATGAT GCTCAGTAGC CTTCCTAGGT GCCCAGCCAT CAGCCTAGCT AGGTCAGTTG TGCAGGTTGG AGGCAGCCAC TTTTCTCTGG CTTTATTTTA TTCCAGTTTG TGATAGCCTC CCCTAGCCTC ATAATCCAGT CCTCAATCTT GTTAAAAACA TATTTCTTTA GAAGTTTTAA GACTGGCATA ACTTCTTGGC TGCAGCTGTG GGAGGAGCCC ATTGGCTTGT CTGCCTGGCC TTTGCCCCCC ATTGCCTCTT CCAGCAGCTT GGCTCTGCTC CAGGCAGGAA ATTCTCTCCT GCTCAACTTT CTTTTGTGCA CTTACAGGTC TCTTTAACTG TCTTTCAAGC CTTTGAACCA TTATCAGCCT TAAGGCAACC TCAGTGAAGC CTTAATACGG AGCTTCTCTG AATAAGAGGA AAGTGGTAAC ATTTCACAAA AAGTACTCTC ACAGGATTTG CAGAATGCCT ATGAGACAGT GTTATGAAAA AGGAAAAAAA AGAACAGTGT AGAAAAATTG AATACTTGCT GAGTGAGCAT AGGTGAATGG AAAATGTTAT GGTCATCTGC ATGAAAAAGC AAATCATAGT GTGACAGCAT TAGGGATACA AAAAGATATA bt-l-109 79

GAGAAGGTAT ACATGTATGG TGTAGGTGGG GCATGTACAA AAAGATGACA AGTAGAATCG GGATTTATTC TAAAGAATAG CCTGTAAGGT GTCCAGAAGC CACATTCTAG TCTTGAGTCT GCCTCTACCT GCTGTGTGCC CTTGAGTACA CCCTTAACCT CCTTGAGCTT CAGAGAGGGA TAATCTTTTT ATTTTATTTT ATTTTATTTT GTTTTGTTTT GTTTTGTTTT GTTTTATGAG ACAGAGTCTC ACTCTGTTGC CCAGGCTGGA GTGCAGTGGT ACAATCTTGG CTTACTGCAT CCTCCACCTC CTGAGTTCAA GCGATTCTCC TTCCTCAGTC TCCTGAATAG CTAGGATTAC AGGTGCACCC CACCACACCC AGCTAATTTT TGTATTTTTA GTAGAGAAGG GGTTTCGCCA TGTTGGCCAG GCTGGTTTTG AAGTCCTGAC CTAAATGATT CATCCACCTC GGCTTCCCAA AGTGCTGGGA TTACAGGCAT GAGCCACCAC GCCTGGCCCA GAGAGGGATG ATCTTTAGAA GCTCGGGATT CTTTCAAGCC CTTTCCTCCT CTCTGAGCTT TCTACTCTCT GATGTCAAAG CATGGTTCCT GGCAGGACCA CCTCACCAGG CTCCCTCCCT CGCTCTCTCC GCAGTGCTCC TTCCAGGACC TGGACCTCTG CCCTCTGGAT GGCGGCATCC AGCTACGAAT CTCCGACCAC CACTACAGCA AGGGCTTCAG GCAGGCCGCG TCAGTTGTTG TGGCCATGGA CAAGCTGAGG AAGATGCTGG TTCCCTGCCC ACAGACCTTC CAGGAGAATG ACCTGAGCAC CTTCTTTCCC TTCATCTTTG AAGAAGGTAG TTAGCCAAGA GCAGGCAGTA GATCTCCACT TGTGTCCTCT TGGAAGTCAT CAAGCCCCAG CCAACTCAAT TCCCCCAGAG CCAAAGCCCT TTAAAGGTAG AAGGCCCAGC GGGGAGACAA AACAAAGAAG GCTGGAAACC AAAGCAATCA TCTCTTTAGT GGAAACTATT CTTAAAGAAG ATCTTGATGG CTACTGACAT TTGCAACTCC CTCACTCTTT CTCAGGGGCC TTTCACTTAC ATTGTCACCA GAGGTTCGTA ACCTCCCTGT GGGCTAGTGT TATGACCATC ACCATTTTAC CTAAGTAGCT CTGTTGCTCG GCCACAGTGA GCAGTAATAG ACCTGAAGCT GGAACCCATG TCTAATAGTG TCAGGTCCAG TGTTCTTAGC CACCCCACTC CCAGCTTCAT CCCTACTGGT GTTGTCATCA GACTTTGACC GTATATGCTC AGGTGTCCTC CAAGAAATCA AATTTTGCCA CCTCGCCTCA CGAGGCCTGC CCTTCTGATT TTATACCTAA ACAACATGTG CTCCACATTT CAGAACCTAT CTTCTTCGAC ACATGGGATA ACGAGGCTTA TGTGCACGAT GCACCTGTAC GATCACTGAA CTGCACGCTC CGGGACTCAC AGCAAAAAAG CTTGGTGATG TCTGGTCCAT ATGAACTGAA AGCTCTCCAC CTCCAGGGAC AGGATATGGA GCAACAAGGT AAATGGAAAC ATCCTGGTTT CCCTGCCTGG CCTCCTGGCA GCTTGCTAAT TCTCCATGTT TTAAACAAAG TAGAAAGTTA ATTTAAGGCA AATGATCAAC ACAAGTGAAA AAAAATATTA AAAAGGAATA TACAAACTTT GGTCCTAGAA ATGGCACATT TGATTGCACT GGCCAGTGCA TTTGTTAACA GGAGTGTGAC CCTGAGAAAT TAGACGGCTC AAGCACTCCC AGGACCATGT CCACCCAAGT CTCTTGGGCA TAGTGCAGTG TCAATTCTTC CACAATATGG GGTCATTTGA TGGACATGGC CTAACTGCCT GTGGGTTCTC TCTTCCTGTT GTTGAGGCTG AAACAAGAGT GCTGGAGCGA TAATGTGTCC ATCCCCCTCC CCAGTCTTCC CCCCTTGCCC CAACATCCGT CCCACCCAAT GCCAGGTGGT TCCTTGTAGG GAAATTTTAC CGCCCAGCAG GAACTTATAT CTCTCCGCTG TAACGGGCAA AAGTTTCAAG TGCGGTGAAC CCATCATTAG CTGTGGTGAT CTGCCTGGCA TCGTGCCACA GTAGCCAAAG CCTCTGCACA GGAGTGTGGG CAACTAAGGC TGCTGACTTT GAAGGACAGC CTCACTCAGG GGGAAGCTAT TTGCTCTCAG CCAGGCCAAG AAAATCCTGT TTCTTTGGAA TCGGGTAGTA AGAGTGATCC CAGGGCCTCC AATTGACACT GCTGTGACTG AGGAAGATCA AAATGAGTGT CTCTCTTTGG AGCCACTTTC CCAGCTCAGC CTCTCCTCTC CCAGTTTCTT CCCATGGGCT ACTCTCTGTT CCTGAAACAG TTCTGGTGCC TGATTTCTGG CAGAAGTACA GCTTCACCTC TTTCCTTTCC TTCCACATTG ATCAAGTTGT TCCGCTCCTG TGGATGGGCA CATTGCCAGC CAGTGACACA ATGGCTTCCT TCCTTCCTTC CTTCAGCATT TAAAATGTAG ACCCTCTTTC ATTCTCCGTT CCTACTGCTA TGAGGCTCTG AGAAACCCTC AGGCCTTTGA GGGGAAACCC TAAATCAACA AAATGACCCT GCTATTGTCT GTGAGAAGTC AAGTTATCCT GTGTCTTAGG CCAAGGAACC TCACTGTGGG TTCCCACAGA GGCTACCAAT TACATGTATC CTACTCTCGG GGCTAGGGGT TGGGGTGACC CTGCATGCTG TGTCCCTAAC CACAAGACCC CCTTCTTTCT TCAGTGGTGT TCTCCATGTC CTTTGTACAA GGAGAAGAAA GTAATGACAA AATACCTGTG GCCTTGGGCC TCAAGGAAAA GAATCTGTAC CTGTCCTGCG TGTTGAAAGA TGATAAGCCC ACTCTACAGC TGGAGGTAAG TGAATGCTAT GGAATGAAGC CCTTCTCAGC CTCCTGCTAC CACTTATTCC CAGACAATTC ACCTTCTCCC CGCCCCCATC CCTAGGAAAA GCTGGGAACA GGTCTATTTG ACAAGTTTTG CATTAATGTA AATAAATTTA ACATAATTTT TAACTGCGTG CAACCTTCAA TCCTGCTGCA GAAAATTAAA TCATTTTGCC GATGTTATTA TGTCCTACCA TAGTTACAAC CCCAACAGAT TATATATTGT TAGGGCTGCT CTCATTTGAT AGACACCTTG GGAAATAGAT GACTTAAAGG GTCCCATTAT CACGTCCACT CCACTCCCAA AATCACCACC ACTATCACCT CCAGCTTTCT CAGCAAAAGC TTCATTTCCA AGTTGATGTC ATTCTAGGAC CATAAGGAAA AATACAATAA AAAGCCCCTG GAAACTAGGT ACTTCAAGAA GCTCTAGCTT AATTTTCACC CCCCCAAAAA AAAAAAATTC TCACCTACAT TATGCTCCTC AGCATTTGGC ACTAAGTTTT AGAAAAGAAG AAGGGCTCTT TTAATAATCA CACAGAAAGT TGGGGGCCCA GTTACAACTC AGGAGTCTGG CTCCTGATCA TGTGACCTGC TCGTCAGTTT CCTTTCTGGC CAACCCAAAG AACATCTTTC CCATAGGCAT CTTTGTCCCT TGCCCCACAA AAATTCTTCT TTCTCTTTCG CTGCAGAGTG TAGATCCCAA AAATTACCCA AAGAAGAAGA TGGAAAAGCG ATTTGTCTTC AACAAGATAG AAATCAATAA CAAGCTGGAA TTTGAGTCTG CCCAGTTCCC CAACTGGTAC ATCAGCACCT CTCAAGCAGA AAACATGCCC GTCTTCCTGG GAGGGACCAA AGGCGGCCAG GATATAACTG ACTTCACCAT GCAATTTGTG TCTTCCTAAA GAGAGCTGTA CCCAGAGAGT CCTGTGCTGA ATGTGGACTC AATCCCTAGG GCTGGCAGAA AGGGAACAGA AAGGTTTTTG AGTACGGCTA TAGCCTGGAC TTTCCTGTTG TCTACACCAA TGCCCAACTG CCTGCCTTAG GGTAGTGCTA AGAGGATCTC CTGTCCATCA GCCAGGACAG TCAGCTCTCT CCTTTCAGGG CCAATCCCCA GCCCTTTTGT TGAGCCAGGC CTCTCTCACC TCTCCTACTC ACTTAAAGCC CGCCTGACAG AAACCACGGC CACATTTGGT TCTAAGAAAC CCTCTGTCAT TCGCTCCCAC ATTCTGATGA GCAACCGCTT CCCTATTTAT TTATTTATTT GTTTGTTTGT TTTGATTCAT TGGTCTAATT TATTCAAAGG GGGCAAGAAG TAGCAGTGTC TGTAAAAGAG CCTAGTTTTT AATAGCTATG GAATCAATTC AATTTGGACT GGTGTGCTCT CTTTAAATCA AGTCCTTTAA TTAAGACTGA AAATATATAA GCTCAGATTA TTTAAATGGG AATATTTATA AATGAGCAAA TATCATACTG TTCAATGGTT CTGAAATAAA CTTCACTGAA GAAAAAAAAA AAAGGGTCTC TCCTGATCAT TGACTGTCTG GATTGACACT GACAGTAAGC AAACAGGCTG TGAGAGTTCT TGGGACTAAG CCCACTCCTC ATTGCTGAGT GCTGCAAGTA CCTAGAAATA TCCTTGGCCA CCGAAGACTA TCCTCCTCAC CCATCCCCTT TATTTCGTTG TTCAACAGAA GGATATTCAG TGCACATCTG GAACAGGATC AGCTGAAGCA CTGCAGGGAG TCAGGACTGG TAGTAACAGC TACCATGATT TATCTATCAA TGCACCAAAC ATCTGTTGAG CAAGCGCTAT GTACTAGGAG CTGGGAGTAC AGAGATGAGA ACAGTCACAA GTCCCTCCTC AGATAGGAGA GGCAGCTAGT TATAAGCAGA ACAAGGTAAC ATGACAAGTA GAGTAAGATA GAAGAACGAA GAGGAGTAGC CAGGAAGGAG GGAGGAGAAC GACATAAGAA TCAAGCCTAA AGGGATAAAC AGAAGATTTC CACACATGGG CTGGGCCAAT TGGGTGTCGG TTACGCCTGT AATCCCAGCA CTTTGGGTGG CAGGGGCAGA AAGATCGCTT GAGCCCAGGA GTTCAAGACC AGCCTGGGCA ACATAGTGAG ACTCCCATCT CTACAAAAAA TAAATAAATA AATAAAACAA TCAGCCAGGC ATGCTGGCAT GCACCTGTAG TCCTAGCTAC TTGGGAAGCT GACACTGGAG GATTGCTTGA GCCCAGAAGT TCAAGACTGC AGTGAGCTTA TCCGTTGACC TGCAGGTCGA C ACAAACCTTT

TCGAGGCAAA AGGCAAAAAA GGCTGCTCTG GGATTCTCTT CAGCCAATCT TCAATGCTCA AGTGTCTGAA GCAGCCATGG CAGAAGTACC TAAGCTCGCC AGTGAAATGA TGGCTTATTA CAGTGGCAAT GAGGATGACT TGTTCTTTGA AGCTGATGGC CCTAAACAGA TGAAGTGCTC CTTCCAGGAC CTGGACCTCT GCCCTCTGGA TGGCGGCATC CAGCTACGAA TCTCCGACCA EPI-109 80

CCACTACAGC AAGGGCTTCA GGCAGGCCGC GTCAGTTGTT GTGGCCATGG ACAAGCTGAG GAAGATGCTG GTTCCCTGCC CACAGACCTT CCAGGAGAAT GACCTGAGCA CCTTCTTTCC CTTCATCTTT GAAGAAGAAC CTATCTTCTT CGACACATGG GATAACGAGG CTTATGTGCA CGATGCACCT GTACGATCAC TGAACTGCAC GCTCCGGGAC TCACAGCAAA AAAGCTTGGT GATGTCTGGT CCATATGAAC TGAAAGCTCT CCACCTCCAG GGACAGGATA TGGAGCAACA AGTGGTGTTC TCCATGTCCT TTGTACAAGG AGAAGAAAGT AATGACAAAA TACCTGTGGC CTTGGGCCTC AAGGAAAAGA ATCTGTACCT GTCCTGCGTG TTGAAAGATG ATAAGCCCAC TCTACAGCTG GAGAGTGTAG ATCCCAAAAA TTACCCAAAG AAGAAGATGG AAAAGCGATT TGTCTTCAAC AAGATAGAAA TCAATAACAA GCTGGAATTT GAGTCTGCCC AGTTCCCCAA CTGGTACATC AGCACCTCTC AAGCAGAAAA CATGCCCGTC TTCCTGGGAG GGACCAAAGG CGGCCAGGAT ATAACTGACT TCACCATGCA ATTTGTGTCT TCCTAAAGAG AGCTGTACCC AGAGAGTCCT GTGCTGAATG TGGACTCAAT CCCTAGGGCT GGCAGAAAGG GAACAGAAAG GTTTTTGAGT ACGGCTATAG CCTGGACTTT CCTGTTGTCT ACACCAATGC CCAACTGCCT GCCTTAGGGT AGTGCTAAGA GGATCTCCTG TCCATCAGCC AGGACAGTCA GCTCTCTCCT TTCAGGGCCA ATCCCAGCCC TTTTGTTGAG CCAGGCCTCT CTCACCTCTC CTACTCACTT AAAGCCCGCC TGACAGAAAC CAGGCCACAT TTTGGTTCTA AGAAACCCTC CTCTGTCATT CGCTCCCACA TTCTGATGAG CAACCGCTTC CCTATTTATT TATTTATTTG TTTGTTTGTT TTGATTCATT GGTCTAATTT ATTCAAAGGG GGCAAGAAGT AGCAGTGTCT GTAAAAGAGC CTAGTTTTTA ATAGCTATGG AATCAATTCA ATTTGGACTG GTGTGCTCTC TTTAAATCAA GTCCTTTAAT TAAGACTGAA AATATATAAG CTCAGATTAT TTAAATGGGA ATATTTATAA ATGAGCAAAT ATCATACTGT TCAATGGTTC TCAAATAAAC TTCACT CTGGCAGGAG TAGCAGCTGC CCCTTGGCGC GACTGCTGGA GCCGCGAACT AGAGAAACAC AGACACGCCT CATAGAGCAA CGGCGTCTCT CGGAGCGTGG AGCCCGCCAA GCTCGAGCTG AGCTTTCGCT TGCCGTCCAC CACTGCCCAC ACTGTCGTTT GCTGCCATCG CAGACCTGCT GCTGACTTCC ATCCCTCTGG ATCCGGCAAG GGCCTGCGAT TTTGACAATG TCAAGATTTA CCGTATATCC CTGTTTGTTT GGATACACCA GTGACGTCCA CTTCTAGAAG ACAAAGTTAT ATTACTTAAA CAACCAAAGA TATGAAACTA TCCATGAAGA ACAATATTAT CAATACACAG CAGTCTTTTG TAACCATGCC CAATGTGATT GTACCAGATA TTGAAAAGGA AATACGAAGG ATGGAAAATG GAGCATGCAG CTCCTTTTCT GAGGATGATG ACAGTGCCTC TACATCTGAA GAATCAGAGA ATGAAAACCC TCATGCAAGG GGTTCCTTTA GTTATAAGTC ACTCAGAAAG GGAGGACCAT CACAGAGGGA GCAGTACCTG CCTGGTGCCA TTGCCATTTT TAATGTGAAC AACAGCGACA ATAAGGACCA GGAACCAGAA GAAAAAAAGA AAAAGAAAAA AGAAAAGAAG AGCAAGTCAG ATGATAAAAA CGAAAATAAA AACGACCCAA AGAAGAAGAT GGAAAAGCGA ATGGCCAAAG

TTCCAGACAT GTTTGAAGAC CTGAAGAACT GTTACAGTGA AAATGAAGAA GACAGTTCCT CCATTGATCA TCTGTCTCTG AATCAGAAAT CCTTCTATCA TGTAAGCTAT GGCCCACTCC ATGAAGGCTG CATGGATCAA TCTGTGTCTC TGAGTATCTC TGAAACCTCT AAAACATCCA AGCTTACCTT CAAGGAGAGC ATGGTGGTAG TAGCAACCAA CGGGAAGGTT CTGAAGAAGA GACGGTTGAG TTTAAGCCAA TCCATCACTG ATGATGACCT GGAGGCCATC GCCAATGACT CAGAGGAAGA AATCATCAAG CCTAGGTCAG CACCTTTTAG CTTCCTGAGC AATGTGAAAT ACAACTTTAT GAGGATCATC AAATACGAAT TCATCCTGAA TGACGCCCTC AATCAAAGTA TAATTCGAGC CAATGATCAG TACCTCACGG CTGCTGCATT ACATAATCTG GATGAAGCAG TGAAATTTGA CATGGGTGCT TATAAGTCAT CAAAGGATGA TGCTAAAATT ACCGTGATTC TAAGAATCTC AAAAACTCAA TTGTATGTGA CTGCCCAAGA TGAAGACCAA CCAGTGCTGC TGAAGGAGAT GCCTGAGATA CCCAAAACCA TCACAGGTAG TGAGACCAAC CTCCTCTTCT TCTGGGAAAC TCACGGCACT AAGAACTATT TCACATCAGT TGCCCATCCA AACTTGTTTA TTGCCACAAA GCAAGACTAC TGGGTGTGCT TGGCAGGGGG GCCACCCTCT ATCACTGACT TTCAGATACT GGAAAACCAG GCGTAGGTCT GGAGTCTCAC TTGTCTCACT TGTGCAGTGT TGACAGTTCA TATGTACCAT GTACATGAAG AAGCTAAATC CTTTACTGTT AGTCATTTGC TGAGCATGTA CTGAGCCTTG TAATTCTAAA TGAATGTTTA CACTCTTTGT AAGAGTGGAA CCAACACTAA CATATAATGT TGTTATTTAA AGAACACCCT ATATTTTGCA TAGTACCAAT CATTTTAATT ATTATTCTTC ATAACAATTT TAGGAGGACC AGAGCTACTG ACTATGGCTA CCAAAAAGAC TCTACCCATA TTACAGATGG GCAAATTAAG GCATAAGAAA ACTAAGAAAT ATGCACAATA GCAGTTGAAA CAAGAAGCCA CAGACCTAGG ATTTCATGAT TTCATTTCAA CTGTTTGCCT TCTGCTTTTA AGTTGCTGAT GAACTCTTAA TCAAATAGCA TAAGTTTCTG GGACCTCAGT TTTATCATTT TCAAAATGGA GGGAATAATA CCTAAGCCTT CCTGCCGCAA CAGTTTTTTA TGCTAATCAG GGAGGTCATT TTGGTAAAAT ACTTCTCGAA GCCGAGCCTC AAGATGAAGG CAAAGCACGA AATGTTATTT TTTAATTATT ATTTATATAT GTATTTATAA ATATATTTAA GATAATTATA ATATACTATA TTTATGGGAA CCCCTTCATC CTCTGAGTGT GACCAGGCAT CCTCCACAAT AGCAGACAGT GTTTTCTGGG ATAAGTAAGT TTGATTTCAT TAATACAGGG CATTTTGGTC CAAGTTGTGC TTATCCCATA GCCAGGAAAC TCTGCATTCT AGTACTTGGG AGACCTGTAA TCATATAATA AATGTACATT AATTACCTTG AGCCAGTAAT TGGTCCGATC TTTGACTCTT TTGCCATTAA ACTTACCTGG GCATTCTTGT TTCATTCAAT TCCACCTGCA ATCAAGTCCT ACAAGCTAAA ATTAGATGAA CTCAACTTTG ACAACCATAG ACCACTGTTA TCAAAACTTT CTTTTCTGGA ATGTAATCAA TGTTTCTTCT AGGTTCTAAA AATTGTGATC AGACCATAAT GTTACATTAT TATCAACAAT AGTGATTGAT AGAGTGTTAT CAGTCATAAC TAAATAAAGC TTGCAAGTGA GGGAGTCATT TCATTGGCGT TTGAGTCAGC AAAGAAGTCA AG AGCTGCCAGC CAGAGAGGGA GTCATTTCAT TGGCGTTTGA GTCAGCAAAG AAGTCAAGAT GGCCAAAGTT CCAGACATGT TTGAAGACCT GAAGAACTGT TACAGTGAAA ATGAAGAAGA CAGTTCCTCC ATTGATCATC TGTCTCTGAA TCAGAAATCC TTCTATCATG TAAGCTATGG CCCACTCCAT GAAGGCTGCA TGGATCAATC TGTGTCTCTG AGTATCTCTG AAACCTCTAA AACATCCAAG CTTACCTTCA AGGAGAGCAT GGTGGTAGTA GCAACCAACG GGAAGGTTCT GAAGAAGAGA CGGTTGAGTT TAAGCCAATC CATCACTGAT GATGACCTGG AGGCCATCGC CAATGACTCA GAGGAAGAAA TCATCAAGCC TAGGTCATCA CCTTTTAGCT TCCTGAGCAA TGTGAAATAC AACTTTATGA GGATCATCAA ATACGAATTC ATCCTGAATG ACGCCCTCAA TCAAAGTATA ATTCGAGCCA ATGATCAGTA CCTCACGGCT GCTGCATTAC ATAATCTGGA TGAAGCAGTG AAATTTGACA TGGGTGCTTA TAAGTCATCA AAGGATGATG CTAAAATTAC CGTGATTCTA AGAATCTCAA AAACTCAATT GTATGTGACT GCCCAAGATG AAGACCAACC AGTGCTGCTG AAGGAGATGC CTGAGATACC CAAAACCATC ACAGGTAGTG AGACCAACCT CCTCTTCTTC TGGGAAACTC ACGGCACTAA GAACTATTTC ACATCAGTTG CCCATCCAAA CTTGTTTATT GCCACAAAGC AAGACTACTG GGTGTGCTTG GCAGGGGGGC CACCCTCTAT CACTGACTTT CAGATACTGG AAAACCAGGC GTAGGTCTGG AGTCTCACTT GTCTCACTTG TGCAGTGTTG ACAGTTCATA TGTACCATGT ACATGAAGAA GCTAAATCCT TTACTGTTAG TCATTTGCTG AGCATGTACT GAGCCTTGTA ATTCTAAATG AATGTTTACA CTCTTTGTAA GAGTGGAACC AACACTAACA TATAATGTTG TTATTTAAAG AACACCCTAT ATTTTGCATA GTACCAATCA TTTTAATTAT TATTCTTCAT AACAATTTTA GGAGGACCAG AGCTACTGAC TATGGCTACC AAAAAGACTC TACCCATATT ACAGATGGGC AAATTAAGGC ATAAGAAAAC TAAGAAATAT GCACAATAGC AGTCGAAACA AGAAGCCACA GACCTAGGAT TTCATGATTT CATTTCAACT GTTTGCCTTC TGCTTTTAAG TTGCTGATGA ACTCTTAATC AAATAGCATA AGTTTCTGGG ACCTCAGTTT TATCATTTTC AAAATGGAGG GAATAATACC TAAGCCTTCC TGCCGCAACA GTTTTTTATG CTAATCAGGG AGGTCATTTT GGTAAAATAC TTCTCGAAGC CGAGCCTCAA GATGAAGGCA AAGCACGAAA TGTTATTTTT TAATTATTAT TTATATATGT ATTTATAAAT ATATTTAAGA bPl-109 81

TAATTATAAT ATACTATATT TATGGGAACC CCTTCATCCT CTGAGTGTGA CCAGGCATCC TCCACAATAG CAGACAGTGT TTTCTGGGAT AAGTAAGTTT GATTTCATTA ATACAGGGCA TTTTGGTCCA AGTTGTGCTT ATCCCATAGC CAGGAAACTC TGCATTCTAG TACTTGGGAG ACCTGTAATC ATATAATAAA TGTACATTAA TTACCTTGAG CCAGTAATTG GTCCGATCTT TGACTCTTTT GCCATTAAAC TTACCTGGGC ATTCTTGTTT CATTCAATTC CACCTGCAAT CAAGTCCTAC AAGCTAAAAT TAGATGAACT CAACTTTGAC AACCATGAGA CCACTGTTAT CAAAACTTTC TTTTCTGGAA TGTAATCAAT GTTTCTTCTA GGTTCTAAAA ATTGTGATCA GACCATAATG TTACATTATT ATCAACAATA GTGATTGATA GAGTGTTATC AGTCATAACT AAATAAAGCT TGCAACAAAA TTCTCTG GCTCAGGGCA CATGCCTCCC CTCCCCAGGC CGCGGCCCAG CTGACCCTCG GGGCTCCCCC GGCAGCGGAC AGGGAAGGGT TAAAGGCCCC CGGCTCCCTG CCCCCTGCCC TGGGGAACCC CTGGCCCTGT GGGGACATGA ACTGTGTTTG CCGCCTGGTC CTGGTCGTGC TGAGCCTGTG GCCAGATACA GCTGTCGCCC CTGGGCCACC ACCTGGCCCC CCTCGAGTTT CCCCAGACCC TCGGGCCGAG CTGGACAGCA CCGTGCTCCT GACCCGCTCT CTCCTGGCGG ACACGCGGCA GCTGGCTGCA CAGCTGAGGG ACAAATTCCC AGCTGACGGG GACCACAACC TGGATTCCCT GCCCACCCTG GCCATGAGTG CGGGGGCACT GGGAGCTCTA CAGCTCCCAG GTGTGCTGAC AAGGCTGCGA GCGGACCTAC TGTCCTACCT GCGGCACGTG CAGTGGCTGC GCCGGGCAGG TGGCTCTTCC CTGAAGACCC TGGAGCCCGA GCTGGGCACC CTGCAGGCCC GACTGGACCG GCTGCTGCGC CGGCTGCAGC TCCTGATGTC CCGCCTGGCC CTGCCCCAGC CACCCCCGGA CCCGCCGGCG CCCCCGCTGG CGCCCCCCTC CTCAGCCTGG GGGGGCATCA GGGCCGCCCA CGCCATCCTG GGGGGGCTGC ACCTGACACT TGACTGGGCC GTGAGGGGAC TGCTGCTGCT GAAGACTCGG CTGTGACCCG GGGCCCAAAG CCACCACCGT CCTTCCAAAG CCAGATCTTA TTTATTTATT TATTTCAGTA CTGGGGGCGA AACAGCCAGG TGATCCCCCC GCCATTATCT CCCCCTAGTT AGAGACAGTC CTTCCGTGAG GCCTGGGGGA CATCTGTGCC TTATTTATAC TTATTTATTT CAGGAGCAGG GGTGGGAGGC AGGTGGACTC CTGGGTCCCC GAGGAGGAGG GGACTGGGGT CCCGGATTCT TGGGTCTCCA AGAAGTCTGT CCACAGACTT CTGCCCTGGC TCTTCCCCAT CTAGGCCTGG GCAGGAACAT ATATTATTTA TTTAAGCAAT TACTTTTCAT GTTGGGGTGG GGACGGAGGG GAAAGGGAAG CCTGGGTTTT TGTACAAAAA TGTGAGAAAC CTTTGTGAGA CAGAGAACAG GGAATTAAAT GTGTCATACA TATCC CAGCTGCGGC ATCCTCTGTC TCAGAGTCTT GGTGTCTCTG TTCCTTTCCC CTCGGGGTCT

CCCTGGGTCT CCCCAAGTCC CTCCTGCTGT CTTCCTCCCG CTCTCTGATC TCTGACTCCC AGAACCTCTC CCTCTGTCTC CAGGGCTGCC CCTCTGATCC TCTTTGCTTC TCTGGTGTGT CTCTCTGGCT GCCTCCATCT CTGTGGATCT CCGTCTCCCT GTCTCTGTCT CAGTCTGTCC TTCACTCTGT GTGTGTGTGT GTCTCTCTCT CTCTCTCTCC TTCCCTTCCA CTCCCTCTTC CTCCTGCCTC CACCTCTCCA GGCCCCTGTC TTGTCCCTCC GTCCGGCCTT TCTCTGCCTT TCCGTCCTCC TGCCTCCCCA TCTCTCTCTG CTAGTCCTGT CCAGCCGGAC CCCCACCCAC AGTCGGGCCC CAGCGCTTGA GCCTGAGTGT CTCCTCCGGC CCGTGGAGGT GGAGGGAGGG GACGCCAATG ACCTCACCAG CCCCTCTCCG ACCACCCCCC CCTTTCCCTT TTCAACTTTT CCAACTTTTC CTTCCGTGCC CTCCTCCGAG CGCGGCGGCG TGAGCCCTGC AAGGCAGCCG CTCCGTCTGA ATGGAAAAGG CAGGCAGGGA GGGTGAGTCA GGATGTGTCA GGCCGGCCCT CCCCTGCCGC CTGCCCCCCG CCCGCCCGCC CCAGGCCCCC TATATAACCC CCCAGGCGTC CACACTCCCT CACTGCCGCG GGCCCTGCTG CTCAGGGCAC ATGCCTCCCC TCCCCAGCCG CGGGCCCAGC TGACCCTCGG GGCTCCCCCG GCAGCGGACA GGGAAGGGTT AAAGGCCCCC GGCTCCCTGC CCCCTGCCCT GGGGAACCCC TGGCCCTGTG GGGACATGAA CTGTAAGTTG GTTCATGGGG AGGGTGGAGG GGACAGGGAG GCAGGGAGGA GAGGGACCCA CGGCGGGGGT GGGAGCAGAC CCCGCTGAGT CGCACAGAGA GGGACCCGGA GACAGGCAGC CGGGGAGGAG AGCAGCTTCG GAGACAGGAG GCGGCGGAGG AGATGGGCAG AGAGAGACAC AGACAGGAGC GGATGGAGGC AGCCAATCAG AGGCGCCGCA GGAGGGACGG GCCAGACAGG GCCCGAGAGG AGCGAGACGC GAGACCGAGC AGGGGCAGGG ACGCAGGGAC TGGTGCCGGG AGGGAGGTGA CCCCCATCGA CCCAGGCCCC AGGGAGCCCG CGGGGACCGG GAGACTCCCT GGGATTCCGG CAGAGAGGCT CCGGAGGGAA ACTGAGGCAG GGTCCGCGGA GAGCGGAGCA AGCCAGGGAG TAGCGACCCC AGCCGGGGGG AGGAGAGAGA CTGGGCGCCG GGGGAAAGCG GGGAGAGCCG GGCAGATGCG GCCGACGGAG GCGCGGACAG ACCGACGGCT GGCGGGCCCG GGGGGCGGGC TGGGGGTGTG CGAGGCGCGG GCGGCCGGGG AGCGCTGATT GGCTGGCGGG TGGCCGGGTG GGCGGGGCGG CCGGGGTGGG CTGCGGGGAG CGAGCTCCGG ACCCCCGCGC CCCCGGCGCC CCCCGCGCCC CCCGCCGCCA GCTCTCCCGC TCCCGGCGCC CGGCCGGGCC ATGGCTCTGC CCCTCTCCGC CCAGGTGCGC TGCGGCCCGG GCTTCTGCCG CCCACCCGGC GGGCTCCTGG GAGGGCGTCT AAGGGGTCTC CCGTGGGAGA GGTCCGTGTC TCCCGGACTC CGTCCTGGGC TTTTGGCTCC TTCCCCTGCT CCCAGCCAGC TCGGGCTCCC GCGGCCCGGG GAGGGGGCAG GTTCTGGCCT GTGCCTCCCC CACCATCCGC GCCCCGGGGC CCAGATTCCG GCGTCCGGGG GCGGACGGGA GACGCCCGGG CCGCGTCTGC TCCGACGGGC GGGGCAGCCA GAGCCAGGGA GGGAGAGGGA AGCCCGCCTG GCCCTGCGAC CTGCCCGCGG GCGTTCCACC CTGGGACTTA AGACCTCCAG CTCCATCCTC CCTAAGGCCG GGAGTCCAGG CCCCAGACCC TCCTCCCCGA GACCCAGGAG TCCAGACCCC AGGCCTTCCT CCCTCAGACC TAGGAGTCCA GGCCCCCAGC CTCTCCTCCC TCAGACCCAG GAGGAGTCCA GACCCCAGTT CCTCCTCCCT CAGACCCGGG AGTCCAGCCC AGGCCCTCCT CTCTCAGACC CGGAGTCCAG CCTGAGCTCT CTGCCTTATC CTGCCCCCAG GTGTTTGCCG CCTGGTCCTG GTCGTGCTGA GCCTGTGGCC AGATACAGCT GTCGCCCCTG GGCCACCACC TGGCCCCCCT CGAGTTTCCC CAGACCCTCG GGCCGAGCTG GACAGCACCG TGCTCCTGAC CCGCTCTCTC CTGGCGGACA CGCGGCAGCT GGCTGCACAG CTGGTAGGAG AGACTGGGCT GGGGCCAGCA CAGGAGTGAG AGGCAGAGAG GAACGGAGAG GAGTCTGCGG GCAGCCACTT GGAGGGGTTC TGGGCTCTCA GGTGGCAGAG TGAGGGAGGG GAAGAGTTGG GGGCCTGGCG TGGGGGATGG AGGGAGCCCC GAGGCTGGGC AGGGGCCACC TCACAGCTTT TTTCCCTGCC AGAGGGACAA ATTCCCAGCT GACGGGGACC ACAACCTGGA TTCCCTGCCC ACCCTGGCCA TGAGTGCAGG GGCACTGGGA GCTCTACAGG TAAGGGCAAG GGAGTGGGCT GGGGACAAGG TGGGAGGCAG GCAGTGAAGG GGGCGGGGAG GATGAGGGGC ACTGGTCGGG TGTTCTCTCA TGTCCCGGCT CTATCCCCAG CTCCCAGGTG TGCTGACAAG GCTGCGAGCG GACCTACTGT CCTACCTGCG GCACGTGCAG TGGCTGCGCC GGGCAGGTGG CTCTTCCCTG AAGACCCTGG AGCCCGAGCT GGGCACCCTG CAGGCCCGAC TGGACCGGCT GCTGCGCCGG CTGCAGCTCC TGGTATGTCC TGGCCCCAAG ACCTGACACC CCAGACCCCC ACCCCTGGCC CCAAAATCCT GTGGCCTGAG TCCTTGAAGC CTGAGACCCC AGACCCGAGT GCAACAGCCC CGCTCTGAGA CCCTGACACC CTAACAGCCC GCTCTGAGAC CCTGACACCG TAACAGCCCC GCTCTGAGAC CCTGACCCTA ACAGTCCTGC TCTGAGACCC TGACCCTGCA GTCCCAAGAT CCTGTGGCCC TGAGACCCTG AGGCCCTAGA CCCCCAAATC CTGCCCAGAA ACTTCAAATT CTCACCCAAG ACCCTGAGAC TCCATCATCC ATGACCTCAA AGTCCCCAGA TCCCAGCCCC TAAGACCCAA GACCCCATCC TGAAGCCCAA AGCCTTGAGA ATTCAAATCC TCACCTCAAG ACTTGGAGAC CCTGGCCCCA TGACATTGAA AACCATGGAC CTGGCCAGGC GTGGTGGCTC ACGCCTGTAA TCCCAGCACT TTGGGAGGCC GAGGCAAGTG GATCACCTGA GGTCGGGAGT TCAAGACCAG CCAGACCAAC ATGGTGAAAC CCTGTCTCTA CTAAAAATAC AAAATTAGCC AGGCGTGGTG GTGCATGCCT GTAATCCCAG CTACTTGGGA GGCTGAGGCA GGAGAATCGC TTGAACCTGG GAGGCGGAGG TTGCAGTGAG CCGAGATCGC ACCATTACAC TCCAGCCTGG GCAACAAGAG CAAAACTCCC TCTCTCTCAA AAAAAAAAAA AAAAAAAAAA AAGAAGGAAA AGAAAACCAT GGACCTCCAG ACCCTGAGAC EPI-109 82

CCCAGGCCCC AGCCCTGAGA TCCTGACATC TTAAAGATCC CAGGCCCTAA GATACAAGAC CTTGACCCAA AGCCAGCCTT GGGACCCTGG CTGTACAAAC CCAAGACCTC CAGGACCTAG ACCCCGAGCC CTGAGGCCCT ATGTCTCACT CCCAACATCG AAAACCCTGA CACCTCAGAT CCTGAGCCTG CGCCTGTACG ACTCCAAGAC CCTCACTTCC AAAGCCAGGC CCAAAGCCCT GAGACCAGAA GACTTCAAAC CCTGGTTCTT GGGCCTAACT CCAAAGACCC TGGATCTCAA ATTCCAACTT CTAGCTCTGA GACTCCAGCC CTCACCCATG AGTTCCTGAA CTTGAACCCA GAGACCCCAT CTCTAAGACT TCAGCCTTGA GATCCAGGGC CTGACCCTAG ACTCGAGCCC ACAGACCTCA GATACTGTCT GTAAAACCCC AGCTCTGGTG GGGAGCAGTG GCTCACTCCT GTAATCCCAA GGCAGGGGAG GCCAAGGCAG AAGGACCTCT TGAGGCCATG AGTTTGAGAC AGCCTGGGCA GCATAGCAAG ACTCTGTTTC TTAATTATTA TTATTATTAT TATTTTTTGG AGACAGAGTC TCGCGCTCTG TTGCCCAGGC TAGAGTGCAA TGGTGCCATT TCGGCTTGCT GGAACCTCCG CCTCCTGGGC TCAAGCGATT CTCCTGCCTC AGCCTCCTGA GTAGCTGGGA CTTCAGGTGC ACACTGCCAC ACCCGGATAA TTTTTTTGTA TTTTAGTAGA CACAGGGTTT CACCGTGTTG CCCAGGCTGG TCACAAACTC CTGAGCTCAG GCCATCCGCC CGCCTCGGCC TCCCAAAGCG CTGGGATAAC AGGCGTGACG CCGCGCCTGG CTTCTTAATT GTTCTAACAG CAGCGACAAC AACAAAAACC CAGCTCTGAG ATTCCAGCCC CGGCGACTCT AACAGTCCCA GGCCCGATCC CTCACCTAGA ACCGAGATGC CAGCCCTGAC TCCACAGACT TCACCCCCAA CCCCCACACT CAGCTCTGGA AGCCCGTCCT GACTCCAGCC TCCATTTTCG GAACCCCACA GCCTGAAGAG CTCCCGGCCT AAACACTTCA CCCCACGCGC CACAGTCCCC CTGTGAATAT GCAGCCCCGA TTCAGCTGCA GCTCCACAGC ACCCCTGCCC TGCACCCCCG CTGCACCCCC TACCTGTGAC TCACCTCTCT CCTCTCCCCA CAGATGTCCC GCCTGGCCCT GCCCCAGCCA CCCCCGGACC CGCCGGCGCC CCCGCTGGCG CCCCCCTCCT CAGCCTGGGG GGGCATCAGG GCCGCCCACG CCATCCTGGG GGGGCTGCAC CTGACACTTG ACTGGGCCGT GAGGGGACTG CTGCTGCTGA AGACTCGGCT GTGACCCGGG GCCCAAAGCC ACCACCGTCC TTCCAAAGCC AGATCTTATT TATTTATTTA TTTCAGTACT GGGGGCGAAA CAGCCAGGTG ATCCCCCCGC CATTATCTCC CCCTAGTTAG AGACAGTCCT TCCGTGAGGC CTGGGGGGCA TCTGTGCCTT ATTTATACTT ATTTATTTCA GGAGCAGGGG TGGGAGGCAG GTGGACTCCT GGGTCCCCGA GGAGGAGGGG ACTGGGGTCC CGGATTCTTG GGTCTCCAAG AAGTCTGTCC ACAGACTTCT GCCCTGGCTC TTCCCCATCT AGGCCTGGGC AGGAACATAT ATTATTTATT TAAGCAATTA CTTTTCATGT TGGGGTGGGG ACGGAGGGGA AAGGGAAGCC TGGGTTTTTG TACAAAAATG TGAGAAACCT TTGTGAGACA GAGAACAGGG AATTAAATGT GTCATACATA TCCACTTGAG GGCGATTTGT CTGAGAGCTG GGGCTGGATG CTTGGGTAAC TGGGGCAGGG CAGGTGGAGG GGAGACCTCC ATTCAGGTGG AGGTCCCGAG TGGGCGGGGC AGCGACTGGG AGATGGGTCG GTCACCCAGA CAGCTCTGTG GAGGCAGGGT CTGAGCCTTG CCTGGGGCCC CGCACTGCAT AGGGCCGTTT GTTTGTTTTT TGAGATGGAG TCTCGCTCTG TTGCCTAGGC TGGAGTGCAG TGAGGCAATC TAAGGTCACT GCAACCTCCA CCTCCCGGGT TCAAGCAATT CTCCTGCCTC AGCCTCCCGA TTAGCTGGGA TCACAGGTGT GCACCACCAT GCCCAGCTAA TTATTTATTT CTTTTGTATT TTTAGTAGAG ACAGGGTTTC ACCATGTTGG CCAGGCTGGT TTCGAACTCC TGACCTCAGG TGATCCTCCT GCCTCGGCCT CCCAAAGTGC TGGGATTACA GGTGTGAGCC ACCACACCTG ACCCATAGGT CTTCAATAAA TATTTAATGG AAGGTTCCAC AAGTCACCCT GTGATCAACA GTACCCGTAT GGGACAAAGC TGCAAGGTCA AGATGGTTCA TTATGGCTGT GTTCACCATA GCAAACTGGA AACAATCTAG ATATCCAACA GTGAGGGTTA AGCAACATGG TGCATCTGTG GATAGAACGC CACCCAGCCG CCCGGAGCAG GGACTGTCAT TCAGGGAGGC TAAGGAGAGA GGCTTGCTTG GGATATAGAA AGATATCCTG ACATTGGCCA GGCATGGTGG CTCACGCCTG TAATCCTGGC ACTTTGGGAG GACGAAGCGA GTGGATCACT GAAGTCCAAG AGTTTGAGAC CGGCCTGCGA GACATGGCAA AACCCTGTCT CAAAAAAGAA AGAATGATGT CCTGACATGA AACAGCAGGC TACAAAACCA CTGCATGCTG TGATCCCAAT TTTGTGTTTT TCTTTCTATA TATGGATTAA AACAAAAATC CTAAAGGGAA ATACGCCAAA ATGTTGACAA TGACTGTCTC CAGGTCAAAG GAGAGAGGTG GGATTGTGGG TGACTTTTAA TGTGTATGAT TGTCTGTATT TTACAGAATT TCTGCCATGA CTGTGTATTT TGCATGACAC ATTTTAAAAA TAATAAACAC TATTTTTAGA ATAACAGAAT ATCAGCCTCC TCCTCTCCAA AAATAAGCCC TCAGGAGGGG ACAAAGTTGA CCGCTGATTG AGCCTGTCAG GGCTGTGCAC-3' (SEQ. ID NO:2411)

Human Adenosine A, Receptor Nucleic Acid and Antisense Oligonucleotide Fragments

₅'-ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTTCTGCTT CATCGTCTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG CCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCCTCTTTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA G ATGAGTGTCA GAAGTGTGAA GGGTGCCTGT TCTGAATCCC AGAGCCTCCT CTCCCTCTGT GAGGCTGGCA GGTGAGGAAG GGTTTAACCT CACTGGAAGG AATCCCTGGA GCTAGCGGCT GCTGAAGGCG TCGAGGTGTG GGGGCACTTG GACAGAACAG TCAGGCAGCC GGGAGCTCTG CCAGCTTTGG TGACCTTGGG CCGGGCTGGG AGCGCTGCGG CGGGAGCCGG AGGACTATGA GCTGCCGCGC GTTGTCCAGA GCCCAGCCCA GCCCTACGCG CGCGGCCCGG AGCTCTGTTC CCTGGAACTT TGGGCACTGC CTCTGGGACC CCTGCCGGCC AGCAGGCAGG ATGGTGCTTG CCTCGTGCCC CTTGGTGCCC GTCTGCTGAT GTGCCCAGCC TGTGCCCGCC ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTTCTGCTT CATCGTGTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCCTCTTTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA EPI-109 83

ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA GACCCCGCCT TCCGCTCCCA CCAGCCCACA TCCAGTGGGG TCTCAGTCCA GTCCTCACAT GCCCGCTGTC CCAGGGGTCT CCCTGAGCCT GCCCCAGCTG GGCTGTTGGC TGGGGGCATG GGGGAGGCTC TGAAGAGATA CCCACAGAGT GTGGTCCCTC CACTAGGAGT TAACTACCCT ACACCTCTGG GCCCTGCAGG AGGCCTGGGA GGGCAAGGGT CCTACGGAGG GACCAGGTGT CTAGAGGCAA CAGTGTTCTG AGCCCCCACC TGCCTGACCA TCCCATGAGC AGTCCAGCGC TTCAGGGCTG GGCAGGTCCT GGGGAGGCTG AGACTGCAGA GGAGCCACCT GGGCTGGGAG AAGGTGCTTG GGCTTCTGCG GTGAGGCAGG GGAGTCTGCT TGTCTTAGAT GTTGGTGGTG CAGCCCCAGG ACCAAGCTTA AGGAGAGGAG AGCATCTGCT CTGAGACGGA TGGAAGGAGA GAGGTTGAGG ATGCACTGGC CTGTTCTGTA GGAGAGACTG GCCAGAGGCA GCTAAGGGGC AGGAATCAAG GAGCCTCCGT TCCCACCTCT GAGGACTCTG GACCCCAGGC CATACCAGGT GCTAGGGTGC CTGCTCTCCT TGCCCTGGGC CAGCCCAGGA TTGTACGTGG GAGAGGCAGA AAGGGTAGGT TCAGTAATCA TTTCTGATGA TTTGCTGGAG TGCTGGCTCC ACGCCCTGGG GAGTGAGCTT GGTGCGGTAG GTGCTGGCCT CAAACAGCCA CGAGGTGGTA GCTCTGAGCC CTCCTTCTTG CCCTGAGCTT TCCGGGGAGG AGCCTGGAGT GTAATTACCT GTCATCTGGG CCACCAGCTC CACTGGCCCC CGTTGCCGGG CCTGGACTGT CCTAGGTGAC CCCATCTCTG CTGCTTCTGG GCCTGATGGA GAGGAGAACA CTAGACATGC CAACTCGGGA GCATTCTGCC TGCCTGGGAA CGGGGTGGAC GAGGGAGTGT CTGTAAGGAC TCAGTGTTGA CTGTAGGCGC CCCTGGGGTG GGTTTAGCAG GCTGCAGCAG GCAGAGGAGG AGTACCCCCC TGAGAGCATG TGGGGGAAGG CCTTGCTGTC ATGTGAATCC CTCAATACCC CTAGTATCTG GCTGGGTTTT CAGGGGCTTT GGAAGCTCTG TTGCAGGTGT CCGGGGGTCT AGGACTTTAG GGATCTGGGA TCTGGGGAAG GACCAACCCA TGCCCTGCCA AGCCTGGAGC CCCTGTGTTG GGGGGCAAGG TGGGGGAGCC TGGAGCCCCT GTGTGGGAGG GCGAGGCGGG GGAGCCTGGA GCCCCTGTGT GGGAGGGCGA GGCGGGGGAT CCTGGAGCCC CTGTGTCGGG GGGCGAGGGA GGGGAGGTGG CCGTCGGTTG ACCTTCTGAA CATGAGTGTC AACTCCAGGA CTTGCTTCCA AGCCCTTCCC TCTGTTGGAA ATTGGGTGTG CCCTGGCTCC CAAGGGAGGC CCATGTGACT AATAAAAAAC TGTGAACCCT CGCATTTGTG TTTTAATAAA AGAATCTGGA AGATAAATAG TCTTGAAGAG AGACAAAGGA AGGAAAATTT AAATCCTTAG ATTCAAGCAG AAGAATTCCA TGTGGAAGGT TTGGGTTGTT GTTGTTGTTG TTTGGTGTGT TTTTTGTTTT TTTGTTTTTT TGTTTTTTTT TGAGATGGAG TCTCGCTGTG TTACCGGGAG CGACAGAGCC GCACGGCCGA GTCGAGTCCC AGCCAGCTAC CATCCCTCTG GAGCTTACCG GCCGGCCTTG GCTTCCCCAG GAATCCCTGG AGCTAGCGGC TGCTGAAGGC GTCGAGGTGT GGGGGCACTT GGACAGAACA GTCAGGCAGC CGGGAGCTCT GCCAGCTTTG GTGACCTTGG GTGCTTGCCT CGTGCCCCTT GGTGCCCGTC TGCTGATGTG CCCAGCCTGT GCCCGCCATG CCGCCCTCCA TCTCAGCTTT CCAGGCCGCC TACATCGGCA TCGAGGTGCT CATCGCCCTG GTCTCTGTGC CCGGGAACGT GCTGGTGATC TGGGCGGTGA AGGTGAACCA GGCGCTGCGG GATGCCACCT TCTGCTTCAT CGTGTCGCTG GCGGTGGCTG ATGTGGCCGT GGGTGCCCTG GTCATCCCCC TCGCCATCCT CATCAACATT GGGCCACAGA CCTACTTCCA CACCTGCCTC ATGGTTGCCT GTCCGGTCCT CATCCTCACC CAGAGCTCCA TCCTGGCCCT GCTGGCAATT GCTGTGGACC GCTACCTCCG GGTCAAGATC CCTCTCCGGT ACAAGATGGT GGTGACCCCC CGGAGGGCGG CGGTGGCCAT AGCCGGCTGC TGGATCCTCT CCTTCGTGGT GGGACTGACC CCTATGTTTG GCTGGAACAA TCTGAGTGCG GTGGAGCGGG CCTGGGCAGC CAACGGCAGC ATGGGGGAGC CCGTGATCAA GTGCGAGTTC GAGAAGGTCA TCAGCATGGA GTACATGGTC TACTTCAACT TCTTTGTGTG GGTGCTGCCC CCGCTTCTCC TCATGGTCCT CATCTACCTG GAGGTCTTCT ACCTAATCCG CAAGCAGCTC AACAAGAAGG TGTCGGCCTC CTCCGGCGAC CCGCAGAAGT ACTATGGGAA GGAGCTGAAG ATCGCCAAGT CGCTGGCCCT CATCCTCTTC CTCTTTGCCC TCAGCTGGCT GCCTTTGCAC ATCCTCAACT GCATCACCCT CTTCTGCCCG TCCTGCCACA AGCCCAGCAT CCTTACCTAC ATTGCCATCT TCCTCACGCA CGGCAACTCG GCCATGAACC CCATTGTCTA TGCCTTCCGC ATCCAGAAGT TCCGCGTCAC CTTCCTTAAG ATTTGGAATG ACCATTTCCG CTGCCAGCCT GCACCTCCCA TTGACGAGGA TCTCCCAGAA GAGAGGCCTG ATGACTAGAC CCCGCCTTCC GCTCCCACCG CCCACATCCA GTGGGGTCTC AGTCCAGTCC TCACATGCCC GCTGTCCCAG GGGTCTCCCT GAGCCTGCCC CAGCTGGGCT GTTGGCTGGG GGCATGGGGG AGGCTCTGAA GAGATACCCA CAGAGTGTGG TCCCTCCACT AGGAGTTAAC TACCCTACAC CTCTGGGCCC TGCAGGAGGC CTGGGAGGGC AAGGGTCCTA CGGAGGGACC AGGTGTCTAG AGGCAACAGT GTTCTGAGCC CCCACCTGCC TGACCATCCC ATGAGCAGTC CAGAGCTTCA GGGCTGGGCA GGTCCTGGGG AGGCTGAGAC TGCAGAGGAG CCACCTGGGC TGGGAGAAGG TGCTTGGGCT TCTGCGGTGA GGCAGGGGAG TCTGCTTGTC TTAGATGTTG GTGGTGCAGC CCCAGGACCA AGCTTAAGGA GAGGAGAGCA TCTGCTCTGA GACGGATGGA AGGAGAGAGG TTGAGGATGC ACTGGCCTGT TCTGTAGGAG AGACTGGCCA GA GAT GGA GGG CGG CAT GGC GGG G CGG GTC GCC GG GGC GGG CBC BGG C GGC GGG CBC GC GGC CTG G GGB GGG CGG C GBT GGB GGG GG CTG GGC GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTTCTGCTT CATCGTCTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCCTCTTTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA G ATGAGTGTCA GAAGTGTGAA GGGTGCCTGT TCTGAATCCC AGAGCCTCCT CTCCCTCTGT GAGGCTGGCA GGTGAGGAAG GGTTTAACCT CACTGGAAGG AATCCCTGGA GCTAGCGGCT GCTGAAGGCG TCGAGGTGTG GGGGCACTTG GACAGAACAG TCAGGCAGCC GGGAGCTCTG CCAGCTTTGG TGACCTTGGG CCGGGCTGGG AGCGCTGCGG CGGGAGCCGG AGGACTATGA GCTGCCGCGC GTTGTCCAGA GCCCAGCCCA GCCCTACGCG CGCGGCCCGG AGCTCTGTTC CCTGGAACTT TGGGCACTGC CTCTGGGACC CCTGCCGGCC AGCAGGCAGG ATGGTGCTTG CCTCGTGCCC CTTGGTGCCC GTCTGCTGAT GTGCCCAGCC TGTGCCCGCC ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTTCTGCTT CATCGTGTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC EPI-109 84

CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCCTCTTTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA GACCCCGCCT TCCGCTCCCA CCAGCCCACA TCCAGTGGGG TCTCAGTCCA GTCCTCACAT GCCCGCTGTC CCAGGGGTCT CCCTGAGCCT GCCCCAGCTG GGCTGTTGGC TGGGGGCATG GGGGAGGCTC TGAAGAGATA CCCACAGAGT GTGGTCCCTC CACTAGGAGT TAACTACCCT ACACCTCTGG GCCCTGCAGG AGGCCTGGGA GGGCAAGGGT CCTACGGAGG GACCAGGTGT CTAGAGGCAA CAGTGTTCTG AGCCCCCACC TGCCTGACCA TCCCATGAGC AGTCCAGCGC TTCAGGGCTG GGCAGGTCCT GGGGAGGCTG AGACTGCAGA GGAGCCACCT GGGCTGGGAG AAGGTGCTTG GGCTTCTGCG GTGAGGCAGG GGAGTCTGCT TGTCTTAGAT GTTGGTGGTG CAGCCCCAGG ACCAAGCTTA AGGAGAGGAG AGCATCTGCT CTGAGACGGA TGGAAGGAGA GAGGTTGAGG ATGCACTGGC CTGTTCTGTA GGAGAGACTG GCCAGAGGCA GCTAAGGGGC AGGAATCAAG GAGCCTCCGT TCCCACCTCT GAGGACTCTG GACCCCAGGC CATACCAGGT GCTAGGGTGC CTGCTCTCCT TGCCCTGGGC CAGCCCAGGA TTGTACGTGG GAGAGGCAGA AAGGGTAGGT TCAGTAATCA TTTCTGATGA TTTGCTGGAG TGCTGGCTCC ACGCCCTGGG GAGTGAGCTT GGTGCGGTAG GTGCTGGCCT CAAACAGCCA CGAGGTGGTA GCTCTGAGCC CTCCTTCTTG CCCTGAGCTT TCCGGGGAGG AGCCTGGAGT GTAATTACCT GTCATCTGGG CCACCAGCTC CACTGGCCCC CGTTGCCGGG CCTGGACTGT CCTAGGTGAC CCCATCTCTG CTGCTTCTGG GCCTGATGGA GAGGAGAACA CTAGACATGC CAACTCGGGA GCATTCTGCC TGCCTGGGAA CGGGGTGGAC GAGGGAGTGT CTGTAAGGAC TCAGTGTTGA CTGTAGGCGC CCCTGGGGTG GGTTTAGCAG GCTGCAGCAG GCAGAGGAGG AGTACCCCCC TGAGAGCATG TGGGGGAAGG CCTTGCTGTC ATGTGAATCC CTCAATACCC CTAGTATCTG GCTGGGTTTT CAGGGGCTTT GGAAGCTCTG TTGCAGGTGT CCGGGGGTCT AGGACTTTAG GGATCTGGGA TCTGGGGAAG GACCAACCCA TGCCCTGCCA AGCCTGGAGC CCCTGTGTTG GGGGGCAAGG TGGGGGAGCC TGGAGCCCCT GTGTGGGAGG GCGAGGCGGG GGAGCCTGGA GCCCCTGTGT GGGAGGGCGA GGCGGGGGAT CCTGGAGCCC CTGTGTCGGG GGGCGAGGGA GGGGAGGTGG CCGTCGGTTG ACCTTCTGAA CATGAGTGTC AACTCCAGGA CTTGCTTCCA AGCCCTTCCC TCTGTTGGAA ATTGGGTGTG CCCTGGCTCC CAAGGGAGGC CCATGTGACT AATAAAAAAC TGTGAACCCT CGCATTTGTG TTTTAATAAA AGAATCTGGA AGATAAATAG TCTTGAAGAG AGACAAAGGA AGGAAAATTT AAATCCTTAG ATTCAAGCAG AAGAATTCCA TGTGGAAGGT TTGGGTTGTT GTTGTTGTTG TTTGGTGTGT TTTTTGTTTT TTTGTTTTTT TGTTTTTTTT TGAGATGGAG TCTCGCTGTG TTACCGGGAG CGACAGAGCC GCACGGCCGA GTCGAGTCCC AGCCAGCTAC CATCCCTCTG GAGCTTACCG GCCGGCCTTG GCTTCCCCAG GAATCCCTGG AGCTAGCGGC TGCTGAAGGC GTCGAGGTGT GGGGGCACTT GGACAGAACA GTCAGGCAGC CGGGAGCTCT GCCAGCTTTG GTGACCTTGG GTGCTTGCCT CGTGCCCCTT GGTGCCCGTC TGCTGATGTG CCCAGCCTGT GCCCGCCATG CCGCCCTCCA TCTCAGCTTT CCAGGCCGCC TACATCGGCA TCGAGGTGCT CATCGCCCTG GTCTCTGTGC CCGGGAACGT GCTGGTGATC TGGGCGGTGA AGGTGAACCA GGCGCTGCGG GATGCCACCT TCTGCTTCAT CGTGTCGCTG GCGGTGGCTG ATGTGGCCGT GGGTGCCCTG GTCATCCCCC TCGCCATCCT CATCAACATT GGGCCACAGA CCTACTTCCA CACCTGCCTC ATGGTTGCCT GTCCGGTCCT CATCCTCACC CAGAGCTCCA TCCTGGCCCT GCTGGCAATT GCTGTGGACC GCTACCTCCG GGTCAAGATC CCTCTCCGGT ACAAGATGGT GGTGACCCCC CGGAGGGCGG CGGTGGCCAT AGCCGGCTGC TGGATCCTCT CCTTCGTGGT GGGACTGACC CCTATGTTTG GCTGGAACAA TCTGAGTGCG GTGGAGCGGG CCTGGGCAGC CAACGGCAGC ATGGGGGAGC CCGTGATCAA GTGCGAGTTC GAGAAGGTCA TCAGCATGGA GTACATGGTC TACTTCAACT TCTTTGTGTG GGTGCTGCCC CCGCTTCTCC TCATGGTCCT CATCTACCTG GAGGTCTTCT ACCTAATCCG CAAGCAGCTC AACAAGAAGG TGTCGGCCTC CTCCGGCGAC CCGCAGAAGT ACTATGGGAA GGAGCTGAAG ATCGCCAAGT CGCTGGCCCT CATCCTCTTC CTCTTTGCCC TCAGCTGGCT GCCTTTGCAC ATCCTCAACT GCATCACCCT CTTCTGCCCG TCCTGCCACA AGCCCAGCAT CCTTACCTAC ATTGCCATCT TCCTCACGCA CGGCAACTCG GCCATGAACC CCATTGTCTA TGCCTTCCGC ATCCAGAAGT TCCGCGTCAC CTTCCTTAAG ATTTGGAATG ACCATTTCCG CTGCCAGCCT GCACCTCCCA TTGACGAGGA TCTCCCAGAA GAGAGGCCTG ATGACTAGAC CCCGCCTTCC GCTCCCACCG CCCACATCCA GTGGGGTCTC AGTCCAGTCC TCACATGCCC GCTGTCCCAG GGGTCTCCCT GAGCCTGCCC CAGCTGGGCT GTTGGCTGGG GGCATGGGGG AGGCTCTGAA GAGATACCCA CAGAGTGTGG TCCCTCCACT AGGAGTTAAC TACCCTACAC CTCTGGGCCC TGCAGGAGGC CTGGGAGGGC AAGGGTCCTA CGGAGGGACC AGGTGTCTAG AGGCAACAGT GTTCTGAGCC CCCACCTGCC TGACCATCCC ATGAGCAGTC CAGAGCTTCA GGGCTGGGCA GGTCCTGGGG AGGCTGAGAC TGCAGAGGAG CCACCTGGGC TGGGAGAAGG TGCTTGGGCT TCTGCGGTGA GGCAGGGGAG TCTGCTTGTC TTAGATGTTG GTGGTGCAGC CCCAGGACCA AGCTTAAGGA GAGGAGAGCA TCTGCTCTGA GACGGATGGA AGGAGAGAGG TTGAGGATGC ACTGGCCTGT TCTGTAGGAG AGACTGGCCA GA -3'(FRAG.NO:_)(SEQ.NO:2423) ₅'-CGCATTTGTG TTTTAATAAA AGAATCTGGA AGATAAATAG TCTTGAAGAG AGACAAAGGA AGGAAAATTT AAATCCTTAG ATTCAAGCAG AAGAATTCCA TGTGGAAGGT TTGGGTTGTT GTTGTTGTTG TTTGGTGTGT TTTTTGTTTT TTTGTTTTTT TGTTTTTTTT TGAGATGGAG TCTCGCTGTG TTACCGGGAG CGACAGAGCC GCACGGCCGA GTCGAGTCCC AGCCAGCTAC CATCCCTCTG GAGCTTACCG GCCGGCCTTG GCTTCCCCAG GAATCCCTGG AGCTAGCGGC TGCTGAAGGC GTCGAGGTGT GGGGGCACTT GGACAGAACA GTCAGGCAGC CGGGAGCTCT GCCAGCTTTG GTGACCTTGG GTGCTTGCCT CGTGCCCCTT GGTGCCCGTC TGCTGATGTG CCCAGCCTGT GCCCGCCATG CCGCCCTCCA TCTCAGCTTT CCAGGCCGCC TACATCGGCA TCGAGGTGCT CATCGCCCTG GTCTCTGTGC CCGGGAACGT GCTGGTGATC TGGGCGGTGA AGGTGAACCA GGCGCTGCGG GATGCCACCT TCTGCTTCAT CGTGTCGCTG GCGGTGGCTG ATGTGGCCGT GGGTGCCCTG GTCATCCCCC TCGCCATCCT CATCAACATT GGGCCACAGA CCTACTTCCA CACCTGCCTC ATGGTTGCCT GTCCGGTCCT CATCCTCACC CAGAGCTCCA TCCTGGCCCT GCTGGCAATT GCTGTGGACC GCTACCTCCG GGTCAAGATC CCTCTCCGGT ACAAGATGGT GGTGACCCCC CGGAGGGCGG CGGTGGCCAT AGCCGGCTGC TGGATCCTCT CCTTCGTGGT GGGACTGACC CCTATGTTTG GCTGGAACAA TCTGAGTGCG GTGGAGCGGG CCTGGGCAGC CAACGGCAGC ATGGGGGAGC CCGTGATCAA GTGCGAGTTC GAGAAGGTCA TCAGCATGGA GTACATGGTC TACTTCAACT TCTTTGTGTG GGTGCTGCCC CCGCTTCTCC TCATGGTCCT CATCTACCTG GAGGTCTTCT ACCTAATCCG CAAGCAGCTC AACAAGAAGG TGTCGGCCTC CTCCGGCGAC CCGCAGAAGT ACTATGGGAA GGAGCTGAAG ATCGCCAAGT CGCTGGCCCT CATCCTCTTC CTCTTTGCCC TCAGCTGGCT GCCTTTGCAC ATCCTCAACT GCATCACCCT CTTCTGCCCG TCCTGCCACA AGCCCAGCAT CCTTACCTAC ATTGCCATCT TCCTCACGCA CGGCAACTCG GCCATGAACC CCATTGTCTA TGCCTTCCGC ATCCAGAAGT TCCGCGTCAC CTTCCTTAAG ATTTGGAATG ACCATTTCCG CTGCCAGCCT GCACCTCCCA TTGACGAGGA TCTCCCAGAA GAGAGGCCTG ATGACTAGAC CCCGCCTTCC EPI-109 85

GCTCCCACCG CCCACATCCA GTGGGGTCTC AGTCCAGTCC TCACATGCCC GCTGTCCCAG GGGTCTCCCT GAGCCTGCCC CAGCTGGGCT GTTGGCTGGG GGCATGGGGG AGGCTCTGAA GAGATACCCA CAGAGTGTGG TCCCTCCACT AGGAGTTAAC TACCCTACAC CTCTGGGCCC TGCAGGAGGC CTGGGAGGGC AAGGGTCCTA CGGAGGGACC AGGTGTCTAG AGGCAACAGT GTTCTGAGCC CCCACCTGCC TGACCATCCC ATGAGCAGTC CAGAGCTTCA GGGCTGGGCA GGTCCTGGGG AGGCTGAGAC TGCAGAGGAG CCACCTGGGC TGGGAGAAGG TGCTTGGGCT TCTGCGGTGA GGCAGGGGAG TCTGCTTGTC TTAGATGTTG GTGGTGCAGC CCCAGGACCA AGCTTAAGGA GAGGAGAGCA TCTGCTCTGA GACGGATGGA AGGAGAGAGG TTGAGGATGC ACTGGCCTGT TCTGTAGGAG AGACTGGCCA GA -3' (FRAG. NO:_)(SEQ. ID NO: 2434)

5'- ATGAGTGTCA GAAGTGTGAA GGGTGCCTGT TCTGAATCCC AGAGCCTCCT CTCCCTCTGT GAGGCTGGCA GGTGAGGAAG GGTTTAACCT CACTGGAAGG AATCCCTGGA GCTAGCGGCT GCTGAAGGCG TCGAGGTGTG GGGGCACTTG GACAGAACAG TCAGGCAGCC GGGAGCTCTG CCAGCTTTGG TGACCTTGGG CCGGGCTGGG AGCGCTGCGG CGGGAGCCGG AGGACTATGA GCTGCCGCGC GTTGTCCAGA GCCCAGCCCA GCCCTACGCG CGCGGCCCGG AGCTCTGTTC CCTGGAACTT TGGGCACTGC CTCTGGGACC CCTGCCGGCC AGCAGGCAGG ATGGTGCTTG CCTCGTGCCC CTTGGTGCCC GTCTGCTGAT GTGCCCAGCC TGTGCCCGCC ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTTCTGCTT CATCGTGTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCCTCTTTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA GACCCCGCCT TCCGCTCCCA CCAGCCCACA TCCAGTGGGG TCTCAGTCCA GTCCTCACAT GCCCGCTGTC CCAGGGGTCT CCCTGAGCCT GCCCCAGCTG GGCTGTTGGC TGGGGGCATG GGGGAGGCTC TGAAGAGATA CCCACAGAGT GTGGTCCCTC CACTAGGAGT TAACTACCCT ACACCTCTGG GCCCTGCAGG AGGCCTGGGA GGGCAAGGGT CCTACGGAGG GACCAGGTGT CTAGAGGCAA CAGTGTTCTG AGCCCCCACC TGCCTGACCA TCCCATGAGC AGTCCAGCGC TTCAGGGCTG GGCAGGTCCT GGGGAGGCTG AGACTGCAGA GGAGCCACCT GGGCTGGGAG AAGGTGCTTG GGCTTCTGCG GTGAGGCAGG GGAGTCTGCT TGTCTTAGAT GTTGGTGGTG CAGCCCCAGG ACCAAGCTTA AGGAGAGGAG AGCATCTGCT CTGAGACGGA TGGAAGGAGA GAGGTTGAGG ATGCACTGGC CTGTTCTGTA GGAGAGACTG GCCAGAGGCA GCTAAGGGGC AGGAATCAAG GAGCCTCCGT TCCCACCTCT GAGGACTCTG GACCCCAGGC CATACCAGGT GCTAGGGTGC CTGCTCTCCT TGCCCTGGGC CAGCCCAGGA TTGTACGTGG GAGAGGCAGA AAGGGTAGGT TCAGTAATCA TTTCTGATGA TTTGCTGGAG TGCTGGCTCC ACGCCCTGGG GAGTGAGCTT GGTGCGGTAG GTGCTGGCCT CAAACAGCCA CGAGGTGGTA GCTCTGAGCC CTCCTTCTTG CCCTGAGCTT TCCGGGGAGG AGCCTGGAGT GTAATTACCT GTCATCTGGG CCACCAGCTC CACTGGCCCC CGTTGCCGGG CCTGGACTGT CCTAGGTGAC CCCATCTCTG CTGCTTCTGG GCCTGATGGA GAGGAGAACA CTAGACATGC CAACTCGGGA GCATTCTGCC TGCCTGGGAA CGGGGTGGAC GAGGGAGTGT CTGTAAGGAC TCAGTGTTGA CTGTAGGCGC CCCTGGGGTG GGTTTAGCAG GCTGCAGCAG GCAGAGGAGG AGTACCCCCC TGAGAGCATG TGGGGGAAGG CCTTGCTGTC ATGTGAATCC CTCAATACCC CTAGTATCTG GCTGGGTTTT CAGGGGCTTT GGAAGCTCTG TTGCAGGTGT CCGGGGGTCT AGGACTTTAG GGATCTGGGA TCTGGGGAAG GACCAACCCA TGCCCTGCCA AGCCTGGAGC CCCTGTGTTG GGGGGCAAGG TGGGGGAGCC TGGAGCCCCT GTGTGGGAGG GCGAGGCGGG GGAGCCTGGA GCCCCTGTGT GGGAGGGCGA GGCGGGGGAT CCTGGAGCCC CTGTGTCGGG GGGCGAGGGA GGGGAGGTGG CCGTCGGTTG ACCTTCTGAA CATGAGTGTC AACTCCAGGA CTTGCTTCCA AGCCCTTCCC TCTGTTGGAA ATTGGGTGTG CCCTGGCTCC CAAGGGAGGC CCATGTGACT AATAAAAAAC TGTGAACCCT -3' (FRAG. NO:_)(SEQ. ID NO: 2433)

5'- ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTTCTGCTT CATCGTCTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCCTCTTTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA G -3' (FRAG. NO:_)(SEQ. ID NO: 2432)

5'-CGCATTTGTG TTTTAATAAA AGAATCTGGA AGATAAATAG TCTTGAAGAG AGACAAAGGA AGGAAAATTT AAATCCTTAG ATTCAAGCAG AAGAATTCCA TGTGGAAGGT TTGGGTTGTT GTTGTTGTTG TTTGGTGTGT TTTTTGTTTT TTTGTTTTTT TGTTTTTTTT TGAGATGGAG TCTCGCTGTG TTACCGGGAG CGACAGAGCC GCACGGCCGA GTCGAGTCCC AGCCAGCTAC CATCCCTCTG GAGCTTACCG GCCGGCCTTG GCTTCCCCAG GAATCCCTGG AGCTAGCGGC TGCTGAAGGC GTCGAGGTGT GGGGGCACTT GGACAGAACA GTCAGGCAGC CGGGAGCTCT GCCAGCTTTG GTGACCTTGG GTGCTTGCCT CGTGCCCCTT GGTGCCCGTC TGCTGATGTG CCCAGCCTGT GCCCGCCATG CCGCCCTCCA TCTCAGCTTT CCAGGCCGCC TACATCGGCA TCGAGGTGCT CATCGCCCTG GTCTCTGTGC CCGGGAACGT GCTGGTGATC TGGGCGGTGA AGGTGAACCA GGCGCTGCGG GATGCCACCT TCTGCTTCAT CGTGTCGCTG GCGGTGGCTG ATGTGGCCGT GGGTGCCCTG GTCATCCCCC TCGCCATCCT CATCAACATT GGGCCACAGA CCTACTTCCA CACCTGCCTC ATGGTTGCCT GTCCGGTCCT CATCCTCACC CAGAGCTCCA TCCTGGCCCT GCTGGCAATT GCTGTGGACC GCTACCTCCG GGTCAAGATC CCTCTCCGGT ACAAGATGGT GGTGACCCCC CGGAGGGCGG CGGTGGCCAT AGCCGGCTGC TGGATCCTCT CCTTCGTGGT GGGACTGACC CCTATGTTTG GCTGGAACAA TCTGAGTGCG GTGGAGCGGG CCTGGGCAGC CAACGGCAGC ATGGGGGAGC CCGTGATCAA GTGCGAGTTC EPI-109 86

GAGAAGGTCA TCAGCATGGA GTACATGGTC TACTTCAACT TCTTTGTGTG GGTGCTGCCC CCGCTTCTCC TCATGGTCCT CATCTACCTG GAGGTCTTCT ACCTAATCCG CAAGCAGCTC AACAAGAAGG TGTCGGCCTC CTCCGGCGAC CCGCAGAAGT ACTATGGGAA GGAGCTGAAG ATCGCCAAGT CGCTGGCCCT CATCCTCTTC CTCTTTGCCC TCAGCTGGCT GCCTTTGCAC ATCCTCAACT GCATCACCCT CTTCTGCCCG TCCTGCCACA AGCCCAGCAT CCTTACCTAC ATTGCCATCT TCCTCACGCA CGGCAACTCG GCCATGAACC CCATTGTCTA TGCCTTCCGC ATCCAGAAGT TCCGCGTCAC CTTCCTTAAG ATTTGGAATG ACCATTTCCG CTGCCAGCCT GCACCTCCCA TTGACGAGGA TCTCCCAGAA GAGAGGCCTG ATGACTAGAC CCCGCCTTCC GCTCCCACCG CCCACATCCA GTGGGGTCTC AGTCCAGTCC TCACATGCCC GCTGTCCCAG GGGTCTCCCT GAGCCTGCCC CAGCTGGGCT GTTGGCTGGG GGCATGGGGG AGGCTCTGAA GAGATACCCA CAGAGTGTGG TCCCTCCACT AGGAGTTAAC TACCCTACAC CTCTGGGCCC TGCAGGAGGC CTGGGAGGGC AAGGGTCCTA CGGAGGGACC AGGTGTCTAG AGGCAACAGT GTTCTGAGCC CCCACCTGCC TGACCATCCC ATGAGCAGTC CAGAGCTTCA GGGCTGGGCA GGTCCTGGGG AGGCTGAGAC TGCAGAGGAG CCACCTGGGC TGGGAGAAGG TGCTTGGGCT TCTGCGGTGA GGCAGGGGAG TCTGCTTGTC TTAGATGTTG GTGGTGCAGC CCCAGGACCA AGCTTAAGGA GAGGAGAGCA TCTGCTCTGA GACGGATGGA AGGAGAGAGG TTGAGGATGC ACTGGCCTGT TCTGTAGGAG AGACTGGCCA GA -3' (FRAG. NO:_)(SEQ. ID NO: 2422)

₅'-ATGAGTGTCA GAAGTGTGAA GGGTGCCTGT TCTGAATCCC AGAGCCTCCT CTCCCTCTGT GAGGCTGGCA GGTGAGGAAG GGTTTAACCT CACTGGAAGG AATCCCTGGA GCTAGCGGCT GCTGAAGGCG TCGAGGTGTG GGGGCACTTG GACAGAACAG TCAGGCAGCC GGGAGCTCTG CCAGCTTTGG TGACCTTGGG CCGGGCTGGG AGCGCTGCGG CGGGAGCCGG AGGACTATGA GCTGCCGCGC GTTGTCCAGA GCCCAGCCCA GCCCTACGCG CGCGGCCCGG AGCTCTGTTC CCTGGAACTT TGGGCACTGC CTCTGGGACC CCTGCCGGCC AGCAGGCAGG ATGGTGCTTG CCTCGTGCCC CTTGGTGCCC GTCTGCTGAT GTGCCCAGCC TGTGCCCGCC ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTTCTGCTT CATCGTGTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCCTCTTTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA GACCCCGCCT TCCGCTCCCA CCAGCCCACA TCCAGTGGGG TCTCAGTCCA GTCCTCACAT GCCCGCTGTC CCAGGGGTCT CCCTGAGCCT GCCCCAGCTG GGCTGTTGGC TGGGGGCATG GGGGAGGCTC TGAAGAGATA CCCACAGAGT GTGGTCCCTC CACTAGGAGT TAACTACCCT ACACCTCTGG GCCCTGCAGG AGGCCTGGGA GGGCAAGGGT CCTACGGAGG GACCAGGTGT CTAGAGGCAA CAGTGTTCTG AGCCCCCACC TGCCTGACCA TCCCATGAGC AGTCCAGCGC TTCAGGGCTG GGCAGGTCCT GGGGAGGCTG AGACTGCAGA GGAGCCACCT GGGCTGGGAG AAGGTGCTTG GGCTTCTGCG GTGAGGCAGG GGAGTCTGCT TGTCTTAGAT GTTGGTGGTG CAGCCCCAGG ACCAAGCTTA AGGAGAGGAG AGCATCTGCT CTGAGACGGA TGGAAGGAGA GAGGTTGAGG ATGCACTGGC CTGTTCTGTA GGAGAGACTG GCCAGAGGCA GCTAAGGGGC AGGAATCAAG GAGCCTCCGT TCCCACCTCT GAGGACTCTG GACCCCAGGC CATACCAGGT GCTAGGGTGC CTGCTCTCCT TGCCCTGGGC CAGCCCAGGA TTGTACGTGG GAGAGGCAGA AAGGGTAGGT TCAGTAATCA TTTCTGATGA TTTGCTGGAG TGCTGGCTCC ACGCCCTGGG GAGTGAGCTT GGTGCGGTAG GTGCTGGCCT CAAACAGCCA CGAGGTGGTA GCTCTGAGCC CTCCTTCTTG CCCTGAGCTT TCCGGGGAGG AGCCTGGAGT GTAATTACCT GTCATCTGGG CCACCAGCTC CACTGGCCCC CGTTGCCGGG CCTGGACTGT CCTAGGTGAC CCCATCTCTG CTGCTTCTGG GCCTGATGGA GAGGAGAACA CTAGACATGC CAACTCGGGA GCATTCTGCC TGCCTGGGAA CGGGGTGGAC GAGGGAGTGT CTGTAAGGAC TCAGTGTTGA CTGTAGGCGC CCCTGGGGTG GGTTTAGCAG GCTGCAGCAG GCAGAGGAGG AGTACCCCCC TGAGAGCATG TGGGGGAAGG CCTTGCTGTC ATGTGAATCC CTCAATACCC CTAGTATCTG GCTGGGTTTT CAGGGGCTTT GGAAGCTCTG TTGCAGGTGT CCGGGGGTCT AGGACTTTAG GGATCTGGGA TCTGGGGAAG GACCAACCCA TGCCCTGCCA AGCCTGGAGC CCCTGTGTTG GGGGGCAAGG TGGGGGAGCC TGGAGCCCCT GTGTGGGAGG GCGAGGCGGG GGAGCCTGGA GCCCCTGTGT GGGAGGGCGA GGCGGGGGAT CCTGGAGCCC CTGTGTCGGG GGGCGAGGGA GGGGAGGTGG CCGTCGGTTG ACCTTCTGAA CATGAGTGTC AACTCCAGGA CTTGCTTCCA AGCCCTTCCC TCTGTTGGAA ATTGGGTGTG CCCTGGCTCC CAAGGGAGGC CCATGTGACT AATAAAAAAC TGTGAACCCT -3' (FRAG. Nθ:_) (SEQ. ID NO: 2421)

5'-ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTTCTGCTT CATCGTCTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG CCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCCTCTTTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA G (FRAG NO: _) (SEQ. ID NO: 2420) S'-GAT GGA GGG CGG CAT GGC GGG-S' (FRAG. NO: 1657) (SEQ ID NO: 1670) 5 -G CGG GTC GCC GG-3' (FRAG. NO: 1658) (SEQ ID NO:1671) 5 -GGC GGG CBC BGG C-3' (FRAG. NO: 1659) (SEQ ID NO: 1672) 5 -GGC GGG CBC-3' (FRAG. NO: 1660) (SEQ ID NO:1673) 5 -GC GGC CTG G-3' (FRAG. NO: 1661) (SEQ ID NO:1674) 5 -GGB GGG CGG C-3' (FRAG. NO: 1662) (SEQ ID NO:1675)

5 -GBT GGB GGG-3' (FRAG. NO: 1663) (SEQ ID NO:1676)

5 '-GG CTG GGC-3' (FRAG. NO: 1664) (SEQ ID NO:1677)

5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG.l) (SEQ. ID NO: 11)

5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 2) (SEQ. ID NO: 12)

S'-GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 3) (SEQ. ID NO: 13)

₅'-GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 4) (SEQ. ID NO: 14)

5'-C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 5) (SEQ. ID NO: 15) '-CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 6) (SEQ. ID NO: 16)

₅'-TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 7) (SEQ. ID NO: 17)

S'-G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 8) (SEQ. ID NO: 18)

₅'-GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 9) (SEQ. ID NO: 19)

5'-AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 10) (SEQ. ID NO: 20)

5'-A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 11) (SEQ. ID NO: 21)

5'-AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 12) (SEQ. ID NO: 22)

₅'-GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 13) (SEQ. ID NO: 23)

₅'-C TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 14) (SEQ. ID NO: 24)

₅'-TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 15) (SEQ. ID NO: 25)

5'-GA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 16) (SEQ. ID NO: 26)

5'-A GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 17) (SEQ. ID NO: 27)

5'-GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 18) (SEQ. ID NO: 28)

5-AT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 19) (SEQ. ID NO: 29)

5'-T GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 20) (SEQ. ID NO: 30)

5'-GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 21) (SEQ. ID NO: 31)

5'-GA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 22) (SEQ. ID NO: 32)

5'-A GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 23) (SEQ. ID NO: 33)

5'-GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 24) (SEQ. ID NO: 34)

5'-GG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 25) (SEQ. ID NO: 35)

5-G CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 26) (SEQ. ID NO: 36)

5'-CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 27) (SEQ. ID NO: 37)

5-GG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 28) (SEQ. ID NO: 38)

5'-G CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 29) (SEQ. ID NO: 39)

5-CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 30) (SEQ. ID NO: 40)

5'-AT GGC GGG CAC AGG CTG GGC-3' (FRAG 31) (SEQ. ID NO: 41)

5'-T GGC GGG CAC AGG CTG GGC-3' (FRAG 32) (SEQ. ID NO: 42)

5'-GGC GGG CAC AGG CTG GGC-3' (FRAG 33) (SEQ. ID NO: 43)

5'-GC GGG CAC AGG CTG GGC-3' (FRAG 34) (SEQ. ID NO: 44)

5'-C GGG CAC AGG CTG GGC-3' (FRAG 35) (SEQ. ID NO: 45)

5'-GGG CAC AGG CTG GGC-3' (FRAG 36) (SEQ. ID NO: 46)

5'-GG CAC AGG CTG GGC-3' (FRAG 37) (SEQ. ID NO: 47)

5'-G CAC AGG CTG GGC-3' (FRAG 38) (SEQ. ID NO: 48)

5'-CAC AGG CTG GGC-3' (FRAG 39) (SEQ. ID NO: 49)

5'-AC AGG CTG GGC-3' (FRAG 40) (SEQ. ID NO: 50)

5 -C AGG CTG GGC-3' (FRAG 41) (SEQ. ID NO: 51)

5'-AGG CTG GGC-3' (FRAG 42) (SEQ. ID NO: 52)

5-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 43) (SEQ. ID NO: 53)

5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 44) (SEQ. ID NO: 54)

5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 45) (SEQ. ID NO: 55)

5-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 46) (SEQ. ID NO: 56)

5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 47) (SEQ. ID NO: 57)

5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 48) (SEQ. ID NO: 58)

5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 49) (SEQ. ID NO: 59)

5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 50) (SEQ. ID NO: 60)

5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 51) (SEQ. ID NO: 61)

5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 52) (SEQ. ID NO: 62)

5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 53) (SEQ. ID NO: 63)

5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 54) (SEQ. ID NO: 64)

5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (FRAG 55) (SEQ. ID NO: 65)

5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 56) (SEQ. ID NO: 66)

5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3'(FRAG 57) (SEQ. ID NO: 67)

5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC -3' (FRAG 58) (SEQ. ID NO: 68)

5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GG -3' (FRAG 59) (SEQ. ID NO: 69)

5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT G -3' (FRAG 60) (SEQ. ID NO: 70)

5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT -3' (FRAG 61) (SEQ. ID NO: 71)

₅'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CA-3' (FRAG 62) (SEQ. ID NO: 72)

5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG C-3' (FRAG 63) (SEQ. ID NO: 73)

5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG -3' (FRAG 64) (SEQ. ID NO: 74)

5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CG -3' (FRAG 65) (SEQ. ID NO: 75)

5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG C -3' (FRAG 66) (SEQ. ID NO: 76)

5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG -3' (FRAG 67) (SEQ. ED NO: 77) bPl-109 88

5'-GGC GGC CTG GAA AGC TGA GAT GGA GG -3' (FRAG 68) (SEQ. ID NO: 78)

5'-GGC GGC CTG GAA AGC TGA GAT GGA G -3' (FRAG 69) (SEQ. ID NO: 79)

5'-GGC GGC CTG GAA AGC TGA GAT GGA -3' (FRAG 70) (SEQ. ID NO: 80)

5'-GGC GGC CTG GAA AGC TGA GAT GG -3' (FRAG 71) (SEQ. ID NO: 81)

5'-GGC GGC CTG GAA AGC TGA GAT G -3' (FRAG 72) (SEQ. ID NO: 82)

5-GGC GGC CTG GAA AGC TGA GAT -3' (FRAG 73) (SEQ. ID NO: 83)

5'-GGC GGC CTG GAA AGC TGA GA-3' (FRAG 74) (SEQ. ID NO: 84)

5'-GGC GGC CTG GAA AGC TGA G-3' (FRAG 75) (SEQ. ID NO: 85)

5'-GGC GGC CTG GAA AGC TGA-3' (FRAG 76) (SEQ. ID NO: 86)

5'-GGC GGC CTG GAA AGC TG-3' (FRAG 77) (SEQ. ID NO: 87)

5'-GGC GGC CTG GAA AGC T-3' (FRAG 78) (SEQ. ID NO: 88)

5'-GGC GGC CTG GAA AGC-3' (FRAG 79) (SEQ. ID NO: 89)

5'-GGC GGC CTG GAA AG-3' (FRAG 80) (SEQ. ID NO: 90)

5'-GGC GGC CTG GAA A-3' (FRAG 81) (SEQ. ID NO: 91)

5'-GGC GGC CTG GAA-3' (FRAG 82) (SEQ. ID NO: 92)

5'-GGC GGC CTG GA-3' (FRAG 83) (SEQ. ID NO: 93)

5'-GGCGGCCTGG-3' (FRAG 84) (SEQ. ID NO: 94)

5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 85) (SEQ. ID NO: 95)

5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 86) (SEQ. ID NO: 96) '-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 87) (SEQ. ID NO: 97)

5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 88) (SEQ. ID NO: 98)

5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 89) (SEQ. ID NO: 99)

5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 90) (SEQ. ID NO: 100)

5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 91) (SEQ. ID NO: 101) '-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 92) (SEQ. ID NO: 102) '-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 93) (SEQ. ID NO: 103)

5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 94) (SEQ. ID NO: 104) -GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 95) (SEQ. ID NO: 105) '-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 96) (SEQ. ID NO: 106) -GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (FRAG 97) (SEQ. ID NO: 107) '-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 98) (SEQ. ID NO: 108) '-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 99) (SEQ. ID NO: 109) '-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC -3' (FRAG 100) (SEQ. ID NO: 110) -GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GG -3' (FRAG 101) (SEQ. ID NO: Ul) '-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT G -3' (FRAG 102) (SEQ. ID NO: 112) '-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT -3' (FRAG 103) (SEQ. ID NO: 113) '-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CA-3' (FRAG 104) (SEQ. ID NO: 114) '-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG C-3' (FRAG 105) (SEQ. ID NO: 115) -GC GGC CTG GAA AGC TGA GAT GGA GGG CGG -3' (FRAG 106) (SEQ. ID NO: 116) -GC GGC CTG GAA AGC TGA GAT GGA GGG CG -3' (FRAG 107) (SEQ. ID NO: 117) '-GC GGC CTG GAA AGC TGA GAT GGA GGG C -3' (FRAG 108) (SEQ. ID NO: 118) '-GC GGC CTG GAA AGC TGA GAT GGA GGG -3' (FRAG 109) (SEQ. ID NO: 119) '-GC GGC CTG GAA AGC TGA GAT GGA GG -3' (FRAG 110) (SEQ. ID NO: 120) '-GC GGC CTG GAA AGC TGA GAT GGA G -3' (FRAG 111) (SEQ. ID NO: 121) '-GC GGC CTG GAA AGC TGA GAT GGA -3' (FRAG 112) (SEQ. ID NO: 122) -GC GGC CTG GAA AGC TGA GAT GG -3' (FRAG 113) (SEQ. ID NO: 123) '-GC GGC CTG GAA AGC TGA GAT G -3' (FRAG 114) (SEQ. ID NO: 124) '-GC GGC CTG GAA AGC TGA GAT -3' (FRAG 115) (SEQ. ID NO: 125) '-GC GGC CTG GAA AGC TGA GA-3' (FRAG 116) (SEQ. ID NO: 126) '-GC GGC CTG GAA AGC TGA G-3' (FRAG 117) (SEQ. ID NO: 127) '-GC GGC CTG GAA AGC TGA-3' (FRAG 118) (SEQ. ID NO: 128) '-GC GGC CTG GAA AGC TG-3' (FRAG 119) (SEQ. ID NO: 129) '-GC GGC CTG GAA AGC T-3' (FRAG 120) (SEQ. ID NO: 130) '-GC GGC CTG GAA AGC-3' (FRAG 121) (SEQ. ID NO: 131) '-GC GGC CTG GAA AG-3' (FRAG 122) (SEQ. ID NO: 132) '-GC GGC CTG GAA A-3' (FRAG 123) (SEQ. ID NO: 133) '-GC GGC CTG GAA-3' (FRAG 124) (SEQ. ID NO: 134) '-GC GGC CTG GA-3' (FRAG 125) (SEQ. ID NO: 135) '-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 126) (SEQ. ID NO: 136) '-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 127) (SEQ. ID NO: 137) '-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 128) (SEQ. ID NO: 138) '-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 129) (SEQ. ID NO: 139) '-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 130) (SEQ. ID NO: 140) '-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 131) (SEQ. ID NO: 141) '-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 132) (SEQ. ID NO: 142) '-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 133) (SEQ. ID NO: 143) '-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 134) (SEQ. ID NO: 144)

5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 135) (SEQ. ID NO: 145) '-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 136) (SEQ. ID NO: 146) bPl-109 89

5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 137) (SEQ. ID NO: 147)

5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (FRAG 138) (SEQ. ID NO: 148)

5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 139) (SEQ. ID NO: 149)

5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 140) (SEQ. ED NO: 150)

5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC -3' (FRAG 141) (SEQ. ID NO: 151)

5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GG -3' (FRAG 142) (SEQ. ID NO: 152)

5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT G -3' (FRA 143) (SEQ. ED NO: 153)

5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT -3' (FRAG 144) (SEQ. ED NO: 154)

5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CA-3' (FRAG 145) (SEQ. ID NO: 155)

5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG C-3' (FRAG 146) (SEQ. ID NO: 156)

5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG -3' (FRAG 147) (SEQ. ID NO: 157)

5'-C GGC CTG GAA AGC TGA GAT GGA GGG CG -3' (FRAG 148) (SEQ. ID NO: 158)

5'-C GGC CTG GAA AGC TGA GAT GGA GGG C -3' (FRAG 148) (SEQ. ID NO: 159)

5'-C GGC CTG GAA AGC TGA GAT GGA GGG -3' (FRAG 150) (SEQ. ID NO: 160) '-C GGC CTG GAA AGC TGA GAT GGA GG -3' (FRAG 151) (SEQ. ID NO: 161)

5'-C GGC CTG GAA AGC TGA GAT GGA G -3' (FRAG 152) (SEQ. ID NO: 162)

5'-C GGC CTG GAA AGC TGA GAT GGA -3' (FRAG 153) (SEQ. ID NO: 163)

5'-C GGC CTG GAA AGC TGA GAT GG -3' (FRAG 154) (SEQ. ID NO: 164)

5'-C GGC CTG GAA AGC TGA GAT G -3' (FRAG 155) (SEQ. ID NO: 165)

5'-C GGC CTG GAA AGC TGA GAT -3' (FRAG 156) (SEQ. ID NO: 166)

5'-C GGC CTG GAA AGC TGA GA-3' (FRAG 157) (SEQ. ID NO: 167)

5'-C GGC CTG GAA AGC TGA G-3' (FRAG 158) (SEQ. ID NO: 168) '-C GGC CTG GAA AGC TGA-3' (FRAG 159) (SEQ. ID NO: 169) '-C GGC CTG GAA AGC TG-3' (FRAG 160) (SEQ. ID NO: 170) '-C GGC CTG GAA AGC T-3' (FRAG 161) (SEQ. ID NO: 171) '-C GGC CTG GAA AGC-3' (FRAG 162) (SEQ. ID NO: 172) '-C GGC CTG GAA AG-3' (FRAG 163) (SEQ. ID NO: 173) '-C GGC CTG GAA A-3' (FRAG 164) (SEQ. ID NO: 174) '-C GGC CTG GAA-3' (FRAG 165) (SEQ. ED NO: 175) '- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 166) (SEQ. ID NO: 176) '- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 167) (SEQ. ID NO: 177) '- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 168) (SEQ. ID NO: 178) '- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 169) (SEQ. ID NO: 179) '- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 170) (SEQ. ID NO: 180) '- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 171) (SEQ. ID NO: 181) '- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 172) (SEQ. ID NO: 182) - GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 173) (SEQ. ID NO: 183) - GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 174) (SEQ. ID NO: 184) - GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 175) (SEQ. ID NO: 185) '- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 176) (SEQ. ID NO: 186) '- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 177) (SEQ. ID NO: 187) '- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (FRAG 178) (SEQ. ID NO: 188) '- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 179) (SEQ. ID NO: 189) '- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 180) (SEQ. ID NO: 190) '- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC -3' (FRAG 181) (SEQ. ID NO: 191) - GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GG -3' (FRAG 182) (SEQ. ID NO: 192) - GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT G -3' (FRAG 183) (SEQ. ID NO: 193) - GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT -3' (FRAG 184) (SEQ. ID NO: 194) '- GGC CTG GAA AGC TGA GAT GGA GGG CGG CA-3' (FRAG 185) (SEQ. ID NO: 195) '- GGC CTG GAA AGC TGA GAT GGA GGG CGG C-3' (FRAG 186) (SEQ. ED NO: 196) '- GGC CTG GAA AGC TGA GAT GGA GGG CGG -3' (FRAG 187) (SEQ. ID NO: 197) '- GGC CTG GAA AGC TGA GAT GGA GGG CG -3' (FRAG 188) (SEQ. ED NO: 198) '- GGC CTG GAA AGC TGA GAT GGA GGG C -3' (FRAG 189) (SEQ. ED NO: 199) '- GGC CTG GAA AGC TGA GAT GGA GGG -3' (FRAG 190) (SEQ. ED NO: 200) '- GGC CTG GAA AGC TGA GAT GGA GG -3' (FRAG 191) (SEQ. ID NO: 201) '- GGC CTG GAA AGC TGA GAT GGA G -3' (FRAG 192) (SEQ. ID NO: 202) '- GGC CTG GAA AGC TGA GAT GGA -3' (FRAG 193) (SEQ. ED NO: 203) '- GGC CTG GAA AGC TGA GAT GG -3' (FRAG 194) (SEQ. ID NO: 204) '- GGC CTG GAA AGC TGA GAT G -3' (FRAG 195) (SEQ. ED NO: 205) '- GGC CTG GAA AGC TGA GAT -3' (FRAG 196) (SEQ. ID NO: 206) '- GGC CTG GAA AGC TGA GA-3' (FRAG 197) (SEQ. ID NO: 207) '- GGC CTG GAA AGC TGA G-3' (FRAG 198) (SEQ. ED NO: 208) '- GGC CTG GAA AGC TGA-3' (FRAG 199) (SEQ. ID NO: 209) '- GGC CTG GAA AGC TG-3' (FRAG 200 (SEQ. ID NO: 210) '- GGC CTG GAA AGC T-3' (FRAG 201) (SEQ. ID NO: 211) '- GGC CTG GAA AGC-3' (FRAG 202) (SEQ. ED NO: 212) '- GGC CTG GAA AG-3' (FRAG 203) (SEQ. ID NO: 213) - GGC CTG GAA A-3' (FRAG 204) (SEQ. ED NO: 214) - GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 205) (SEQ. ID NO: 215) EPI-109 90

5- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 206) (SEQ. ID NO: 216)

5- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 207) (SEQ. ID NO: 217)

5 - GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 208) (SEQ. ID NO: 218)

5- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 209) (SEQ. ID NO: 219)

5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 210) (SEQ. ID NO: 220)

5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 211) (SEQ. ID NO: 221)

5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 212) (SEQ. ID NO: 222)

5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 213) (SEQ. ID NO: 223)

5- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 214) (SEQ. ID NO: 224)

5- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 215) (SEQ. ID NO: 225)

5- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 216) (SEQ. ID NO: 226)

5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (FRAG 217) (SEQ. ID NO: 227)

5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 218) (SEQ. ID NO: 228)

5- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 219) (SEQ. ED NO: 229)

5-GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC -3' (FRAG 220) (SEQ. ID NO: 230)

5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GG -3' (FRAG 221) (SEQ. ED NO: 231)

5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT G -3' (FRAG 222) (SEQ. ED NO: 232)

5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT -3' (FRAG 223) (SEQ. ID NO: 233)

5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CA-3' (FRAG 224) (SEQ. ID NO: 234)

5'- GC CTG GAA AGC TGA GAT GGA GGG CGG C-3' (FRAG 225) (SEQ. ID NO: 235)

5-GC CTG GAA AGC TGA GAT GGA GGG CGG -3' (FRAG 226) (SEQ. ID NO: 236)

5'- GC CTG GAA AGC TGA GAT GGA GGG CG -3" (FRAG 227) (SEQ. ID NO: 237)

5- GC CTG GAA AGC TGA GAT GGA GGG C -3' (FRAG 228) (SEQ. ID NO: 238)

5'- GC CTG GAA AGC TGA GAT GGA GGG -3' (FRAG 229) (SEQ. ID NO: 239)

5'- GC CTG GAA AGC TGA GAT GGA GG -3' (FRAG 230) (SEQ. ID NO: 240)

5- GC CTG GAA AGC TGA GAT GGA G -3' (FRAG 231) (SEQ. ID NO: 241) -GC CTG GAA AGC TGA GAT GGA -3' (FRAG 232) (SEQ. ID NO: 242) -GC CTG GAA AGC TGA GAT GG -3' (FRAG 233) (SEQ. ID NO: 243) '- GC CTG GAA AGC TGA GAT G -3' (FRAG 234) (SEQ. ID NO: 244) '- GC CTG GAA AGC TGA GAT -3' (FRAG 235) (SEQ. ID NO: 245) '- GC CTG GAA AGC TGA GA-3' (FRAG 236) (SEQ. ID NO: 246) '- GC CTG GAA AGC TGA G-3' (FRAG 237) (SEQ. ID NO: 247) '- GC CTG GAA AGC TGA-3' (FRAG 238) (SEQ. ID NO: 248) '- GC CTG GAA AGC TG-3' (FRAG 239) (SEQ. ID NO: 249) '- GC CTG GAA AGC T-3' (FRAG 240) (SEQ. ID NO: 250) '- GC CTG GAA AGC-3' (FRAG 241) (SEQ. ID NO: 251) '- GC CTG GAA AG-3' (FRAG 2₄2) (SEQ. ID NO: 252) - C CTG GAA AGC TGA GAT GG A GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 243) (SEQ. ID NO: 253) '- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 244) (SEQ. ID NO: 254) '- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 245) (SEQ. ID NO: 255) - C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 246) (SEQ. ID NO: 256) - C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3" (FRAG 247) (SEQ. ID NO: 257) - C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 248) (SEQ. ID NO: 258) '- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 249) (SEQ. ID NO: 259) - C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 250) (SEQ. ID NO: 260) '- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 251) (SEQ. ID NO: 261) - C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 252) (SEQ. ID NO: 262) - C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 253) (SEQ. ID NO: 263) - C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3" (FRAG 254) (SEQ. ID NO: 264) '- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (FRAG 255) (SEQ. ID NO: 265) '- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 256) (SEQ. ID NO: 266) '- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 257) (SEQ. ID NO: 267) '- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC -3' (FRAG 258) (SEQ. ID NO: 268) '- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GG -3' (FRAG 259) (SEQ. ID NO: 269) '- C CTG GAA AGC TGA GAT GGA GGG CGG CAT G -3' (FRAG 260) (SEQ. ID NO: 270) '- C CTG GAA AGC TGA GAT GGA GGG CGG CAT -3' (FRAG 261) (SEQ. ID NO: 271) '- C CTG GAA AGC TGA GAT GGA GGG CGG CA-3' (FRAG 262) (SEQ. ID NO: 272) '- C CTG GAA AGC TGA GAT GGA GGG CGG C-3' (FRAG 263) (SEQ. ID NO: 273) '- C CTG GAA AGC TGA GAT GGA GGG CGG -3' (FRAG 264) (SEQ. ID NO: 274) '- C CTG GAA AGC TGA GAT GGA GGG CG -3' (FRAG 265) (SEQ. ID NO: 275) '- C CTG GAA AGC TGA GAT GGA GGG C -3' (FRAG 266) (SEQ. ID NO: 276) '- C CTG GAA AGC TGA GAT GGA GGG -3' (FRAG 267) (SEQ. ID NO: 277) '- C CTG GAA AGC TGA GAT GGA GG -3' (FRAG 268) (SEQ. ID NO: 278) '- C CTG GAA AGC TGA GAT GGA G -3' (FRAG 269) (SEQ. ID NO: 279) '- C CTG GAA AGC TGA GAT GGA -3' (FRAG 270) (SEQ. ED NO: 280) '- C CTG GAA AGC TGA GAT GG -3' (FRAG 271) (SEQ. ID NO: 281) '- C CTG GAA AGC TGA GAT G -3' (FRAG 272) (SEQ. ED NO: 282) '- C CTG GAA AGC TGA GAT -3' (FRAG 273) (SEQ. ED NO: 283) '- C CTG GAA AGC TGA GA-3' (FRAG 274) (SEQ. ID NO: 284) EPI-109 91

5'- C CTG GAA AGC TGA G-3' (FRAG 275) (SEQ. ED NO: 285)

5'- C CTG GAA AGC TGA-3' (FRAG 276) (SEQ. ID NO: 286)

5'- C CTG GAA AGC TG-3' (FRAG 277) (SEQ. ED NO: 287)

5'- C CTG GAA AGC T-3' (FRAG 278) (SEQ. ID NO: 288)

5'- C CTG GAA AGC-3' (FRAG 279) (SEQ. ID NO: 289)

5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 280) (SEQ. ID NO: 290)

5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 281) (SEQ. ID NO: 291)

5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 282) (SEQ. ID NO: 292)

5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 283) (SEQ. ID NO: 293)

5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 284) (SEQ. ID NO: 294)

5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 285) (SEQ. ID NO: 295)

5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 286) (SEQ. ID NO: 296)

5- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 287) (SEQ. ED NO: 297)

5- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 288) (SEQ. ID NO: 298)

5- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 289) (SEQ. ID NO: 299)

5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 290) (SEQ. ID NO: 300)

5- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 291) (SEQ. ID NO: 301)

5- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (FRAG 292) (SEQ. ID NO: 302)

5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 293) (SEQ. ID NO: 303)

5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 294) (SEQ. ID NO: 304)

5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC -3' (FRAG 295) (SEQ. ID NO: 305)

5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GG -3' (FRAG 296) (SEQ. ID NO: 306)

5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT G -3' (FRAG 297) (SEQ. ID NO: 307)

5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT -3' (FRAG 298) (SEQ. ID NO: 308)

5'- CTG GAA AGC TGA GAT GGA GGG CGG CA-3' (FRAG 299) (SEQ. ID NO: 309)

5'- CTG GAA AGC TGA GAT GGA GGG CGG C-3' (FRAG 300) (SEQ. ID NO: 310)

5- CTG GAA AGC TGA GAT GGA GGG CGG -3' (FRAG 301) (SEQ. ID NO: 311) '- CTG GAA AGC TGA GAT GGA GGG CG -3' (FRAG 302) (SEQ. ID NO: 312) '- CTG GAA AGC TGA GAT GGA GGG C -3' (FRAG 303) (SEQ. ED NO: 313) '- CTG GAA AGC TGA GAT GGA GGG -3' (FRAG 304) (SEQ. ID NO: 314) '- CTG GAA AGC TGA GAT GGA GG -3' (FRAG 305) (SEQ. ED NO: 315) '- CTG GAA AGC TGA GAT GGA G -3' (FRAG 306) (SEQ. ID NO: 316) '- CTG GAA AGC TGA GAT GGA -3' (FRAG 307) (SEQ. ID NO: 317) '- CTG GAA AGC TGA GAT GG -3' (FRAG 308) (SEQ. ID NO: 318) '- CTG GAA AGC TGA GAT G -3' (FRAG 309) (SEQ. ID NO: 319) '- CTG GAA AGC TGA GAT -3' (FRAG 310) (SEQ. ID NO: 320) '- CTG GAA AGC TGA GA-3' (FRAG 311) (SEQ. ID NO: 321) '- CTG GAA AGC TGA G-3' (FRAG 312) (SEQ. ID NO: 322) '- CTG GAA AGC TGA-3' (FRAG 313) (SEQ. ID NO: 323) '- CTG GAA AGC TG-3' (FRAG 314) (SEQ. ID NO: 324) '- CTG GAA AGC T-3' (FRAG 315) (SEQ. ID NO: 325) '- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 316) (SEQ. ID NO: 326) '- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 317) (SEQ. ID NO: 327) '- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 318) (SEQ. ID NO: 328) '- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 319) (SEQ. ID NO: 329) '- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 320) (SEQ. ID NO: 330) '- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 321) (SEQ. ID NO: 331) '- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 322) (SEQ. ID NO: 332) '- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 323) (SEQ. ID NO: 333) '- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 324) (SEQ. ED NO: 334) '- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 325) (SEQ. ID NO: 335) '- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 326) (SEQ. ED NO: 336) '- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 327) (SEQ. ED NO: 337) '- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (FRAG 328) (SEQ. ID NO: 338) '- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 329) (SEQ. ED NO: 339) '- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 330) (SEQ. ID NO: 340) - TG GAA AGC TGA GAT GGA GGG CGG CAT GGC -3' (FRAG 331) (SEQ. ID NO: 341) '- TG GAA AGC TGA GAT GGA GGG CGG CAT GG -3' (FRAG 332) (SEQ. ID NO: 342) '- TG GAA AGC TGA GAT GGA GGG CGG CAT G -3' (FRAG 333) (SEQ. ID NO: 343) '- TG GAA AGC TGA GAT GGA GGG CGG CAT -3' (FRAG 334) (SEQ. ID NO: 344) '- TG GAA AGC TGA GAT GGA GGG CGG CA-3' (FRAG 335) (SEQ. ID NO: 345) '- TG GAA AGC TGA GAT GGA GGG CGG C-3' (FRAG 336) (SEQ. ID NO: 346) '- TG GAA AGC TGA GAT GGA GGG CGG -3' (FRAG 337) (SEQ. ID NO: 347) '- TG GAA AGC TGA GAT GGA GGG CG -3' (FRAG 338) (SEQ. ID NO: 348) '- TG GAA AGC TGA GAT GGA GGG C -3' (FRAG 339) (SEQ. ED NO: 349) '- TG GAA AGC TGA GAT GGA GGG -3' (FRAG 340) (SEQ. ID NO: 350) '- TG GAA AGC TGA GAT GGA GG -3' (FRAG 341) (SEQ. ID NO: 351) '- TG GAA AGC TGA GAT GGA G -3' (FRAG 342) (SEQ. ED NO: 352) '- TG GAA AGC TGA GAT GGA -3' (FRAG 343) (SEQ. ID NO: 353) EPI-109 92

5'- TG GAA AGC TGA GAT GG -3' (FRAG 344) (SEQ. ID NO: 354)

5'- TG GAA AGC TGA GAT G -3' (FRAG 345) (SEQ. ID NO: 355)

5'- TG GAA AGC TGA GAT -3' (FRAG 346) (SEQ. ID NO: 356)

5'- TG GAA AGC TGA GA-3' (FRAG 347) (SEQ. ID NO: 357)

5'- TG GAA AGC TGA G-3' (FRAG 348) (SEQ. ID NO: 358)

5'- TG GAA AGC TGA-3' (FRAG 349) (SEQ. ED NO: 359)

5'- TG GAA AGC TG-3' (FRAG 350) (SEQ. ID NO: 360)

5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 351) (SEQ. ID NO: 361)

5- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 352) (SEQ. ID NO: 362)

5- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 353) (SEQ. ED NO: 363)

5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 354) (SEQ. ED NO: 364)

5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 355) (SEQ. ID NO: 365)

5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 356) (SEQ. ID NO: 366)

5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 357) (SEQ. ID NO: 367)

5- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 358) (SEQ. ID NO: 368)

5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 359) (SEQ. ID NO: 369)

5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 360) (SEQ. ID NO: 370)

5- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 361) (SEQ. ID NO: 371)

5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 362) (SEQ. ID NO: 372)

5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (FRAG 363) (SEQ. ID NO: 373)

5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 364) (SEQ. ID NO: 374)

5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 365) (SEQ. ID NO: 375)

5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC -3' (FRAG 366) (SEQ. ID NO: 376)

5'- G GAA AGC TGA GAT GGA GGG CGG CAT GG -3' (FRAG 367) (SEQ. ID NO: 377)

5'- G GAA AGC TGA GAT GGA GGG CGG CAT G -3' (FRAG 368) (SEQ. ID NO: 378) '- G GAA AGC TGA GAT GGA GGG CGG CAT -3' (FRAG 369) (SEQ. ID NO: 379) '- G GAA AGC TGA GAT GGA GGG CGG CA-3' (FRAG 370) (SEQ. ID NO: 380) - G GAA AGC TGA GAT GGA GGG CGG C-3' (FRAG 371) (SEQ. ID NO: 381) '- G GAA AGC TGA GAT GGA GGG CGG -3' (FRAG 372) (SEQ. ID NO: 382) '- G GAA AGC TGA GAT GGA GGG CG -3' (FRAG 373) (SEQ. ID NO: 383) '- G GAA AGC TGA GAT GGA GGG C -3' (FRAG 374) (SEQ. ID NO: 384) '- G GAA AGC TGA GAT GGA GGG -3' (FRAG 375) (SEQ. ID NO: 385) '- G GAA AGC TGA GAT GGA GG -3' (FRAG 376) (SEQ. ID NO: 386) '- G GAA AGC TGA GAT GGA G -3' (FRAG 377) (SEQ. ID NO: 387) '- G GAA AGC TGA GAT GGA -3' (FRAG 378) (SEQ. ID NO: 388) '- G GAA AGC TGA GAT GG -3' (FRAG 379) (SEQ. ID NO: 389) '- G GAA AGC TGA GAT G -3' (FRAG 380) (SEQ. ED NO: 390) - G GAA AGC TGA GAT -3' (FRAG 381) (SEQ. ID NO: 391) '- G GAA AGC TGA GA-3' (FRAG 382) (SEQ. ID NO: 392) '- G GAA AGC TGA G-3' (FRAG 383) (SEQ. ID NO: 393) - G GAA AGC TGA-3' (FRAG 384) (SEQ. ID NO: 394) '- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 385) (SEQ. ID NO: 395) - GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 386) (SEQ. ID NO: 396) '- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 387) (SEQ. ID NO: 397) - GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 388) (SEQ. ID NO: 398) - GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 389) (SEQ. ID NO: 399) '- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 390) (SEQ. ID NO: 400) '- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 391) (SEQ. ID NO: 401) - GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 392) (SEQ. ID NO: 402) - GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 393) (SEQ. ID NO: 403) '- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 394) (SEQ. ID NO: 404) '- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 395) (SEQ. ID NO: 405) '- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 396) (SEQ. ID NO: 406) '- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (FRAG 397) (SEQ. ID NO: 407) '- GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 398) (SEQ. ID NO: 408) '- GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 399) (SEQ. ED NO: 409) '- GAA AGC TGA GAT GGA GGG CGG CAT GGC -3' (FRAG 400) (SEQ. ID NO: 410) '- GAA AGC TGA GAT GGA GGG CGG CAT GG -3' (FRAG 401) (SEQ. ED NO: 411) '- GAA AGC TGA GAT GGA GGG CGG CAT G -3' (FRAG 402) (SEQ. ED NO: 412) '- GAA AGC TGA GAT GGA GGG CGG CAT -3' (FRAG 403) (SEQ. ID NO: 413) '- GAA AGC TGA GAT GGA GGG CGG CA-3' (FRAG 404) (SEQ. ID NO: 414) '- GAA AGC TGA GAT GGA GGG CGG C-3' (FRAG 405) (SEQ. ID NO: 415) '- GAA AGC TGA GAT GGA GGG CGG -3' (FRAG 406) (SEQ. ID NO: 416) '- GAA AGC TGA GAT GGA GGG CG -3' (FRAG 407) (SEQ. ID NO: 417) '- GAA AGC TGA GAT GGA GGG C -3' (FRAG 408) (SEQ. ID NO: 418) '- GAA AGC TGA GAT GGA GGG -3' (FRAG 409) (SEQ. ID NO: 419) '- GAA AGC TGA GAT GGA GG -3' (FRAG 410) (SEQ. ED NO: 420) '- GAA AGC TGA GAT GGA G -3' (FRAG 411) (SEQ. ID NO: 421) '- GAA AGC TGA GAT GGA -3' (FRAG 412) (SEQ. ED NO: 422) EPI-109 93

5'- GAA AGC TGA GAT GG -3' (FRAG 413) (SEQ. ID NO: 423)

5'- GAA AGC TGA GAT G -3' (FRAG 414) (SEQ. ID NO: 424)

5'- GAA AGC TGA GAT -3' (FRAG 415) (SEQ. ED NO: 425)

5'- GAA AGC TGA GA-3' (FRAG 416) (SEQ. ID NO: 426)

5'- GAA AGC TGA G-3' (FRAG 417) (SEQ. ID NO: 427)

5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 418) (SEQ. ID NO: 428)

5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 419) (SEQ. ID NO: 429)

5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 420) (SEQ. ID NO: 430)

5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 421) (SEQ. ID NO: 431)

5- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 422) (SEQ. ID NO: 432)

5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 423) (SEQ. ID NO: 433)

5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3'(FRAG 424) (SEQ. ID NO: 434)

5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 425) (SEQ. ID NO: 435)

5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 426) (SEQ. ID NO: 436)

5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 427) (SEQ. ID NO: 437)

5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 428) (SEQ. ID NO: 438)

5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 429) (SEQ. ED NO: 439)

5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (FRAG 430) (SEQ. ID NO: 440)

5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 431) (SEQ. ID NO: 441)

5- AA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 432) (SEQ. ID NO: 442)

5'- AA AGC TGA GAT GGA GGG CGG CAT GGC -3' (FRAG 433) (SEQ. ID NO: 443)

5'- AA AGC TGA GAT GGA GGG CGG CAT GG -3' (FRAG 434) (SEQ. ID NO: 444)

5'- AA AGC TGA GAT GGA GGG CGG CAT G -3' (FRAG 435) (SEQ. ID NO: 445)

5'- AA AGC TGA GAT GGA GGG CGG CAT -3' (FRAG 436) (SEQ. ID NO: 446)

5'- AA AGC TGA GAT GGA GGG CGG CA-3' (FRAG 437) (SEQ. ID NO: 447)

5'- AA AGC TGA GAT GGA GGG CGG C-3' (FRAG 438) (SEQ. ID NO: 448)

5'- AA AGC TGA GAT GGA GGG CGG -3' (FRAG 439) (SEQ. ID NO: 449)

5'- AA AGC TGA GAT GGA GGG CG -3' (FRAG 440) (SEQ. ID NO: 450)

5'- AA AGC TGA GAT GGA GGG C -3' (FRAG 441) (SEQ. ID NO: 451) - AA AGC TGA GAT GGA GGG -3' (FRAG 442) (SEQ. ID NO: 452)

5'- AA AGC TGA GAT GGA GG -3' (FRAG 443) (SEQ. ID NO: 453) - AA AGC TGA GAT GGA G -3' (FRAG 444) (SEQ. ID NO: 454) '- AA AGC TGA GAT GGA -3' (FRAG 445) (SEQ. ID NO: 455) '- AA AGC TGA GAT GG -3' (FRAG 446) (SEQ. ID NO: 456) '- AA AGC TGA GAT G -3' (FRAG 447) (SEQ. ID NO: 457)

5'- AA AGC TGA GAT -3' (FRAG 448) (SEQ. ID NO: 458)

5'- AA AGC TGA GA-3' (FRAG 449) (SEQ. ID NO: 459)

5'- A AGC TGA GAT GGA GGG CG G CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 450) (SEQ. ID NO: 460)

5- A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 451) (SEQ. ID NO: 461) - A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 452) (SEQ. ID NO: 462) - A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 453) (SEQ. ID NO: 463)

5- A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 454) (SEQ. ID NO: 464) - A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 455) (SEQ. ID NO: 465) - A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 456) (SEQ. ID NO: 466) '- A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 457) (SEQ. ID NO: 467) '- A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 458) (SEQ. ED NO: 468) '- A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 459) (SEQ. ED NO: 469) - A AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 460) (SEQ. ID NO: 470) '- A AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 461) (SEQ. ED NO: 471) '- A AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (FRAG 462) (SEQ. ED NO: 472) '- A AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 463) (SEQ. ID NO: 473) - A AGC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 464) (SEQ. ID NO: 474) '- A AGC TGA GAT GGA GGG CGG CAT GGC -3' (FRAG 465) (SEQ. ED NO: 475) '- A AGC TGA GAT GGA GGG CGG CAT GG -3" (FRAG 466) (SEQ. ID NO: 476) '- A AGC TGA GAT GGA GGG CGG CAT G -3' (FRAG 467) (SEQ. ED NO: 477) '- A AGC TGA GAT GGA GGG CGG CAT -3' (FRAG 468) (SEQ. ID NO: 478) '- A AGC TGA GAT GGA GGG CGG CA-3' (FRAG 469) (SEQ. ED NO: 479) '- A AGC TGA GAT GGA GGG CGG C-3' (FRAG 470) (SEQ. ID NO: 480) '- A AGC TGA GAT GGA GGG CGG -3' (FRAG 471) (SEQ. ID NO: 481)

5'- A AGC TGA GAT GGA GGG CG -3' (FRAG 472) (SEQ. ID NO: 482)

5'- A AGC TGA GAT GGA GGG C -3' (FRAG 473) (SEQ. ID NO: 483) '- A AGC TGA GAT GGA GGG -3' (FRAG 474) (SEQ. ID NO: 484)

5'- A AGC TGA GAT GGA GG -3' (FRAG 475) (SEQ. ED NO: 485) '- A AGC TGA GAT GGA G -3' (FRAG 476) (SEQ. ED NO: 486)

5'- A AGC TGA GAT GGA -3' (FRAG 477) (SEQ. ID NO: 487) '- A AGC TGA GAT GG -3' (FRAG 478) (SEQ. ED NO: 488) '- A AGC TGA GAT G -3' (FRAG 479) (SEQ. ED NO: 489)

5'- A AGC TGA GAT -3' (FRAG 480) (SEQ. ID NO: 490)

5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 481) (SEQ. ID NO: 491) EPI-109 94

5- AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 482) (SEQ. ID NO: 492)

5- AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 483) (SEQ. ID NO: 493)

5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 484) (SEQ. ID NO: 494)

5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 485) (SEQ. ED NO: 495)

5- AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 486) (SEQ. ID NO: 496)

5- AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 487) (SEQ. ID NO: 497)

5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 488) (SEQ. ED NO: 498)

5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 489) (SEQ. ED NO: 499)

5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 490) (SEQ. ED NO: 500)

5- AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 491) (SEQ. ID NO: 501)

5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 492) (SEQ. ED NO: 502)

5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (FRAG 493) (SEQ. ED NO: 503)

5 - AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 494) (SEQ. ID NO: 504)

5- AGC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 495) (SEQ. ID NO: 505)

5- AGC TGA GAT GGA GGG CGG CAT GGC -3' (FRAG 496) (SEQ. ED NO: 506)

5- AGC TGA GAT GGA GGG CGG CAT GG -3' (FRAG 497) (SEQ. ID NO: 507)

5- AGC TGA GAT GGA GGG CGG CAT G -3' (FRAG 498) (SEQ. ID NO: 508) - AGC TGA GAT GGA GGG CGG CAT -3' (FRAG 499) (SEQ. ID NO: 509) '- AGC TGA GAT GGA GGG CGG CA-3' (FRAG 500) (SEQ. ID NO: 510) '- AGC TGA GAT GGA GGG CGG C-3' (FRAG 501) (SEQ. ID NO: 511) '- AGC TGA GAT GGA GGG CGG -3' (FRAG 502) (SEQ. ID NO: 512) - AGC TGA GAT GGA GGG CG -3' (FRAG 503) (SEQ. ID NO: 513) '- AGC TGA GAT GGA GGG C -3' (FRAG 504) (SEQ. ID NO: 514) - AGC TGA GAT GGA GGG -3' (FRAG 505) (SEQ. ID NO: 515) - AGC TGA GAT GGA GG -3' (FRAG 506) (SEQ. ID NO: 516) '- AGC TGA GAT GGA G -3' (FRAG 507) (SEQ. ID NO: 517) '- AGC TGA GAT GGA -3' (FRAG 508) (SEQ. ID NO: 518) - AGC TGA GAT GG -3' (FRAG 509) (SEQ. ID NO: 519) '- AGC TGA GAT G -3' (FRAG 510) (SEQ. ID NO: 520) '- GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 511) (SEQ. ID NO: 521) - GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 512) (SEQ. ID NO: 522) '- GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 513) (SEQ. ID NO: 523) '- GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 514) (SEQ. ED NO: 524) '- GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 515) (SEQ. ID NO: 525) '- GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 516) (SEQ. ID NO: 526) '- GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 517) (SEQ. ID NO: 527) - GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 518) (SEQ. ID NO: 528) - GC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 519) (SEQ. ED NO: 529) '- GC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 520) (SEQ. ID NO: 530) '- GC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 521) (SEQ. ID NO: 531) '- GC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 522) (SEQ. ID NO: 532) - GC TGA GAT GGA GGG CGG CAT GGC GGG -3' (FRAG 523) (SEQ. ED NO: 533) - GC TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 524) (SEQ. ID NO: 534) - GC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 525) (SEQ. ID NO: 535) - GC TGA GAT GGA GGG CGG CAT GGC -3' (FRAG 526) (SEQ. ED NO: 536) - GC TGA GAT GGA GGG CGG CAT GG -3' (FRAG 527) (SEQ. ID NO: 537) '- GC TGA GAT GGA GGG CGG CAT G -3' (FRAG 528) (SEQ. ID NO: 538) - GC TGA GAT GGA GGG CGG CAT -3' (FRAG 529) (SEQ. ID NO: 539) - GC TGA GAT GGA GGG CGG CA-3' (FRAG 530) (SEQ. ID NO: 540) '- GC TGA GAT GGA GGG CGG C-3' (FRAG 531) (SEQ. ID NO: 541) '- GC TGA GAT GGA GGG CGG -3' (FRAG 532) (SEQ. ID NO: 542) '- GC TGA GAT GGA GGG CG -3' (FRAG 533) (SEQ. ID NO: 543) '- GC TGA GAT GGA GGG C -3' (FRAG 534) (SEQ. ID NO: 544) '- GC TGA GAT GGA GGG -3' (FRAG 535) (SEQ. ID NO: 545) '- GC TGA GAT GGA GG -3' (FRAG 536) (SEQ. ID NO: 546) '- GC TGA GAT GGA G -3' (FRAG 537) (SEQ. ED NO: 547) '- GC TGA GAT GGA -3' (FRAG 538) (SEQ. ID NO: 548) - GC TGA GAT GG -3' (FRAG 539) (SEQ. ED NO: 549) '- C TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 540) (SEQ. ED NO: 550) - C TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 541) (SEQ. ID NO: 551) - C TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 542) (SEQ. ED NO: 552) '- C TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 543) (SEQ. ID NO: 553) '- C TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 544) (SEQ. ED NO: 554) '- C TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 545) (SEQ. ID NO: 555) '- C TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 546) (SEQ. ID NO: 556) '- C TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 547) (SEQ. ED NO: 557) '- C TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 548) (SEQ. ID NO: 558) - C TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 549) (SEQ. ED NO: 559) - C TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 550) (SEQ. ID NO: 560) EPI-109 95

5'- C TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 551) (SEQ. ID NO: 561)

5'- C TGA GAT GGA GGG CGG CAT GGC GGG -3' (FRAG 552) (SEQ. ID NO: 562)

5- C TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 553) (SEQ. ID NO: 563)

5- C TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 554) (SEQ. ID NO: 564)

5'- C TGA GAT GGA GGG CGG CAT GGC -3' (FRAG 555) (SEQ. ID NO: 565)

5- C TGA GAT GGA GGG CGG CAT GG -3' (FRAG 556) (SEQ. ID NO: 566)

5'- C TGA GAT GGA GGG CGG CAT G -3' (FRAG 557) (SEQ. ID NO: 567)

5'- C TGA GAT GGA GGG CGG CAT -3' (FRAG 558) (SEQ. ID NO: 568)

5- C TGA GAT GGA GGG CGG CA-3' (FRAG 559) (SEQ. ED NO: 569)

5'- C TGA GAT GGA GGG CGG C-3' (FRAG 560) (SEQ. ID NO: 570)

5'- C TGA GAT GGA GGG CGG -3' (FRAG 561) (SEQ. ED NO: 571)

5- C TGA GAT GGA GGG CG -3' (FRAG 562) (SEQ. ED NO: 572)

5- C TGA GAT GGA GGG C -3' (FRAG 563) (SEQ. ED NO: 573)

5'- C TGA GAT GGA GGG -3' (FRAG 564) (SEQ. ID NO: 574)

5- C TGA GAT GGA GG -3' (FRAG 565) (SEQ. ID NO: 575)

5- C TGA GAT GGA G -3' (FRAG 566) (SEQ. ED NO: 576)

5'- C TGA GAT GGA -3' (FRAG 567) (SEQ. ID NO: 577)

5- TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 568) (SEQ. ID NO: 578)

5'- TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 569) (SEQ. ID NO: 579)

5- TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 570) (SEQ. ID NO: 580)

5- TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 571) (SEQ. ID NO: 581)

5'- TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 572) (SEQ. ID NO: 582)

5'- TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 573) (SEQ. ID NO: 583)

5- TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 574) (SEQ. ID NO: 584)

5'- TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 575) (SEQ. ID NO: 585)

5- TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 576) (SEQ. ID NO: 586)

5'- TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 577) (SEQ. ID NO: 587)

5- TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 578) (SEQ. ID NO: 588)

5'- TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 579) (SEQ. ID NO: 589)

5- TGA GAT GGA GGG CGG CAT GGC GGG -3' (FRAG 580) (SEQ. ID NO: 590)

5'- TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 581) (SEQ. ID NO: 591)

5'- TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 582) (SEQ. ID NO: 592)

5- TGA GAT GGA GGG CGG CAT GGC -3' (FRAG 583) (SEQ. ID NO: 593)

5'- TGA GAT GGA GGG CGG CAT GG -3' (FRAG 584) (SEQ. ID NO: 594)

5- TGA GAT GGA GGG CGG CAT G -3' (FRAG 585) (SEQ. ID NO: 595)

5'- TGA GAT GGA GGG CGG CAT -3' (FRAG 586) (SEQ. ID NO: 596)

5'- TGA GAT GGA GGG CGG CA-3' (FRAG 587) (SEQ. ID NO: 597)

5'- TGA GAT GGA GGG CGG C-3' (FRAG 588) (SEQ. ID NO: 598)

5- TGA GAT GGA GGG CGG -3' (FRAG 589) (SEQ. ID NO: 599)

5- TGA GAT GGA GGG CG -3' (FRAG 590) (SEQ. ID NO: 600)

5- TGA GAT GGA GGG C -3' (FRAG 591) (SEQ. ID NO: 601)

5'- TGA GAT GGA GGG -3' (FRAG 592) (SEQ. ID NO: 602)

5- TGA GAT GGA GG -3' (FRAG 593) (SEQ. ID NO: 603)

5- TGA GAT GGA G -3' (FRAG 594) (SEQ. ID NO: 604)

5 - GA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 595) (SEQ. ID NO: 605)

5- GA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 596) (SEQ. ID NO: 606)

5- GA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 597) (SEQ. ID NO: 607)

5- GA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 598) (SEQ. ID NO: 608)

5- GA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 599) (SEQ. ED NO: 609)

5'- GA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 600) (SEQ. ID NO: 610)

5'- GA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 601) (SEQ. ID NO: 611)

5- GA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 602) (SEQ. ID NO: 612)

5- GA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 603) (SEQ. ID NO: 613)

5'- GA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 604) (SEQ. ID NO: 614)

5- GA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 605) (SEQ. ID NO: 615)

5'- GA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 606) (SEQ. ID NO: 616)

5- GA GAT GGA GGG CGG CAT GGC GGG -3' (FRAG 607) (SEQ. ID NO: 617)

5'- GA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 608) (SEQ. ID NO: 618)

5'- GA GAT GGA GGG CGG CAT GGC G-3' (FRAG 609) (SEQ. ID NO: 619)

5'- GA GAT GGA GGG CGG CAT GGC -3' (FRAG 610) (SEQ. ID NO: 620)

5- GA GAT GGA GGG CGG CAT GG -3' (FRAG 611) (SEQ. ED NO: 621)

5'- GA GAT GGA GGG CGG CAT G -3' (FRAG 612) (SEQ. ID NO: 622)

5'- GA GAT GGA GGG CGG CAT -3' (FRAG 613) (SEQ. ID NO: 623)

5'- GA GAT GGA GGG CGG CA-3' (FRAG 614) (SEQ. ID NO: 624)

5- GA GAT GGA GGG CGG C-3' (FRAG 615) (SEQ. ED NO: 625)

5'- GA GAT GGA GGG CGG -3' (FRAG 616) (SEQ. ID NO: 626)

5'- GA GAT GGA GGG CG -3' (FRAG 617) (SEQ. ED NO: 627)

5- GA GAT GGA GGG C -3' (FRAG 618) (SEQ. ED NO: 628)

5- GA GAT GGA GGG -3' (FRAG 619) (SEQ. ED NO: 629) EPI-109 96

5'- GA GAT GGA GG -3' (FRAG 620) (SEQ. ID NO: 630)

5'- A GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 621) (SEQ. ID NO: 631)

5- A GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 622) (SEQ. ID NO: 632)

5'- A GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 623) (SEQ. ID NO: 633)

5'- A GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 624) (SEQ. ID NO: 634)

5'- A GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 625) (SEQ. ID NO: 635)

5'- A GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 626) (SEQ. ID NO: 636)

5- A GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 627) (SEQ. ED NO: 637)

5 - A GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 628) (SEQ. ID NO: 638)

5 - A GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 629) (SEQ. ID NO: 639)

5'- A GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 630) (SEQ. ED NO: 640)

5'- A GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 631) (SEQ. ED NO: 641)

5'- A GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 632) (SEQ. ID NO: 642)

5'- A GAT GGA GGG CGG CAT GGC GGG -3' (FRAG 633) (SEQ. ID NO: 643)

5- A GAT GGA GGG CGG CAT GGC GG-3' (FRAG 634) (SEQ. ED NO: 644)

5 - A GAT GGA GGG CGG CAT GGC G-3' (FRAG 635) (SEQ. ED NO: 645)

5- A GAT GGA GGG CGG CAT GGC -3' (FRAG 636) (SEQ. ID NO: 646)

5- A GAT GGA GGG CGG CAT GG -3' (FRAG 637) (SEQ. ID NO: 647)

5'- A GAT GGA GGG CGG CAT G -3' (FRAG 638) (SEQ. ID NO: 648)

5'- A GAT GGA GGG CGG CAT -3' (FRAG 639) (SEQ. ID NO: 649)

5'- A GAT GGA GGG CGG CA-3' (FRAG 640) (SEQ. ID NO: 650)

5'- A GAT GGA GGG CGG C-3' (FRAG 641) (SEQ. ID NO: 651)

5'- A GAT GGA GGG CGG -3' (FRAG 642) (SEQ. ID NO: 652)

5'- A GAT GGA GGG CG -3' (FRAG 643) (SEQ. ID NO: 653)

5- A GAT GGA GGG C -3' (FRAG 644) (SEQ. ED NO: 654)

5'- A GAT GGA GGG -3' (FRAG 645) (SEQ. ID NO: 655)

5- GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 646) (SEQ. ID NO: 656)

5- GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 647) (SEQ. ED NO: 657)

5'- GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 648) (SEQ. ID NO: 658)

5- GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 6) (SEQ. ID NO: 659)

5'- GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 650) (SEQ. ID NO: 660)

5'- GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 651) (SEQ. ID NO: 661)

5'- GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 652) (SEQ. ID NO: 662)

5- GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 653) (SEQ. ID NO: 663)

5'- GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 654) (SEQ. ED NO: 664)

5- GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 655) (SEQ. ED NO: 665)

5- GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 656) (SEQ. ID NO: 666)

5'- GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 657) (SEQ. ID NO: 667)

5'- GAT GGA GGG CGG CAT GGC GGG -3' (FRAG 658) (SEQ. ID NO: 668)

5'- GAT GGA GGG CGG CAT GGC GG-3' (FRAG 659) (SEQ. ID NO: 669)

5- GAT GGA GGG CGG CAT GGC G-3' (FRAG 660) (SEQ. ID NO: 670)

5 - GAT GGA GGG CGG CAT GGC -3' (FRAG 661) (SEQ. ID NO: 671)

5 - GAT GGA GGG CGG CAT GG -3' (FRAG 662) (SEQ. ID NO: 672)

5 - GAT GGA GGG CGG CAT G -3' (FRAG 663) (SEQ. ID NO: 673)

5- GAT GGA GGG CGG CAT -3' (FRAG 664) (SEQ. ID NO: 674)

5- GAT GGA GGG CGG CA-3' (FRAG 665) (SEQ. ID NO: 675)

5- GAT GGA GGG CGG C-3' (FRAG 666) (SEQ. ID NO: 676)

5- GAT GGA GGG CGG -3' (FRAG 667) (SEQ. ID NO: 677)

5 - GAT GGA GGG CG -3' (FRAG 668) (SEQ. ID NO: 678)

5- GAT GGA GGG C -3' (FRAG 669) (SEQ. ED NO: 679)

5'- AT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 670) (SEQ. ID NO: 680)

5'- AT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 671) (SEQ. ID NO: 681)

5'- AT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 672) (SEQ. ED NO: 682)

5'- AT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 673) (SEQ. ID NO: 683)

5'- AT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 674) (SEQ. ID NO: 684)

5'- AT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 675) (SEQ. ID NO: 685)

5- AT GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 676) (SEQ. ID NO: 686)

5'- AT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 677) (SEQ. ED NO: 687)

5'- AT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 678) (SEQ. ED NO: 688)

5'- AT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 679) (SEQ. ID NO: 689)

5- AT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 680) (SEQ. ID NO: 690)

5'- AT GGA GGG CGG CAT GGC GGG C-3' (FRAG 681) (SEQ. ID NO: 691)

5'- AT GGA GGG CGG CAT GGC GGG -3' (FRAG 682) (SEQ. ID NO: 692)

5'- AT GGA GGG CGG CAT GGC GG-3' (FRAG 683) (SEQ. ID NO: 693)

5'- AT GGA GGG CGG CAT GGC G-3' (FRAG 684) (SEQ. ID NO: 694)

₅'- AT GGA GGG CGG CAT GGC -3' (FRAG 685) (SEQ. ID NO: 695)

5- AT GGA GGG CGG CAT GG -3' (FRAG 686) (SEQ. ID NO: 696)

5^'- AT GGA GGG CGG CAT G -3' (FRAG 687) (SEQ. ID NO: 697)

5- AT GGA GGG CGG CAT -3" (FRAG 688) (SEQ. ID NO: 698) EPI-109 97

5- AT GGA GGG CGG CA-3' (FRAG 689) (SEQ. ID NO: 699)

5- AT GGA GGG CGG C-3' (FRAG 690) (SEQ. ID NO: 700)

5'- AT GGA GGG CGG -3' (FRAG 691) (SEQ. ID NO: 701)

5'- AT GGA GGG CG -3' (FRAG 692) (SEQ. ID NO: 702)

5- T GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 693) (SEQ. ID NO: 703)

5- T GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 694) (SEQ. ID NO: 704)

5'- T GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 695) (SEQ. ED NO: 705)

5- T GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 696) (SEQ. ED NO: 706)

5'- T GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 697) (SEQ. ED NO: 707)

5- T GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 698) (SEQ. ID NO: 708)

5- T GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 699) (SEQ. ED NO: 709)

5- T GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 700) (SEQ. ED NO: 710)

5- T GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 701) (SEQ. ED NO: 711)

5- T GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 702) (SEQ. ED NO: 712)

5- T GGA GGG CGG CAT GGC GGG CA-3' (FRAG 703) (SEQ. ED NO: 713)

5- T GGA GGG CGG CAT GGC GGG C-3' (FRAG 704) (SEQ. ID NO: 714)

5'- T GGA GGG CGG CAT GGC GGG -3' (FRAG 705) (SEQ. ID NO: 715)

5- T GGA GGG CGG CAT GGC GG-3' (FRAG 706) (SEQ. ID NO: 716)

5- T GGA GGG CGG CAT GGC G-3' (FRAG 707) (SEQ. ID NO: 717)

5- T GGA GGG CGG CAT GGC -3' (FRAG 708) (SEQ. ID NO: 718)

5- T GGA GGG CGG CAT GG -3' (FRAG 709) (SEQ. ID NO: 719)

5'- T GGA GGG CGG CAT G -3' (FRAG 710) (SEQ. ID NO: 720)

5'- T GGA GGG CGG CAT -3' (FRAG 711) (SEQ. ID NO: 721)

5'- T GGA GGG CGG CA-3' (FRAG 712) (SEQ. ID NO: 722)

5- T GGA GGG CGG C-3' (FRAG 713) (SEQ. ID NO: 723)

5'- T GGA GGG CGG -3' (FRAG 714) (SEQ. ID NO: 724)

5 - GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 715) (SEQ. ID NO: 725)

5'- GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 716) (SEQ. ED NO: 726)

5'- GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 717) (SEQ. ID NO: 727)

5- GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 718) (SEQ. ID NO: 728)

5- GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 719) (SEQ. ID NO: 729)

5- GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 720) (SEQ. ID NO: 730)

5- GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 721) (SEQ. ID NO: 731)

5- GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 722) (SEQ. ED NO: 732)

5- GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 723) (SEQ. ED NO: 733)

5- GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 724) (SEQ. ED NO: 734)

5- GGA GGG CGG CAT GGC GGG CA-3' (FRAG 725) (SEQ. ED NO: 735)

5 - GGA GGG CGG CAT GGC GGG C-3' (FRAG 726) (SEQ. ID NO: 736)

5- GGA GGG CGG CAT GGC GGG -3' (FRAG 727) (SEQ. ID NO: 737)

5 - GGA GGG CGG CAT GGC GG-3' (FRAG 728) (SEQ. ID NO: 738)

5- GGA GGG CGG CAT GGC G-3' (FRAG 729) (SEQ. ID NO: 739)

5- GGA GGG CGG CAT GGC -3' (FRAG 730) (SEQ. ID NO: 740)

5 - GGA GGG CGG CAT GG -3' (FRAG 731) (SEQ. ID NO: 741)

5'- GGA GGG CGG CAT G -3' (FRAG 732) (SEQ. ID NO: 742)

5- GGA GGG CGG CAT -3' (FRAG 733) (SEQ. ID NO: 743)

5'- GGA GGG CGG CA-3' (FRAG 734) (SEQ. ID NO: 744)

5'- GGA GGG CGG C-3' (FRAG 735) (SEQ. ID NO: 745)

5'- GA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 736) (SEQ. ID NO: 746)

5- GA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 737) (SEQ. ID NO: 747)

5- GA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 738) (SEQ. ID NO: 748)

5'- GA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 739) (SEQ. ID NO: 749)

5'- GA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 740) (SEQ. ID NO: 750)

5'- GA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 741) (SEQ. ID NO: 751)

5- GA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 742) (SEQ. ED NO: 752)

5- GA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 743) (SEQ. ID NO: 753)

5'- GA GGG CGG CAT GGC GGG CAC A-3' (FRAG 744) (SEQ. ED NO: 754)

5'- GA GGG CGG CAT GGC GGG CAC-3' (FRAG 745) (SEQ. ID NO: 755)

5- GA GGG CGG CAT GGC GGG CA-3' (FRAG 746) (SEQ. ID NO: 756)

5- GA GGG CGG CAT GGC GGG C-3' (FRAG 747) (SEQ. ID NO: 757)

5'- GA GGG CGG CAT GGC GGG -3' (FRAG 748) (SEQ. ED NO: 758)

5- GA GGG CGG CAT GGC GG-3' (FRAG 749) (SEQ. ED NO: 759)

5- GA GGG CGG CAT GGC G-3' (FRAG 750) (SEQ. ID NO: 760)

5'- GA GGG CGG CAT GGC -3' (FRAG 751) (SEQ. ID NO: 761)

5- GA GGG CGG CAT GG -3' (FRAG 752) (SEQ. ED NO: 762)

5'- GA GGG CGG CAT G -3' (FRAG 753) (SEQ. ID NO: 763)

5'- GA GGG CGG CAT -3' (FRAG 754) (SEQ. ED NO: 764)

5'- GA GGG CGG CA-3' (FRAG 755) (SEQ. ID NO: 765)

5'- A GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 756) (SEQ. ID NO: 766)

5'- A GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 757) (SEQ. ED NO: 767) EPI-109 98

5- A GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 758) (SEQ. ED NO: 768)

5'- A GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 759) (SEQ. ED NO: 769)

5 - A GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 760) (SEQ. ID NO: 770)

5- A GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 761) (SEQ. ID NO: 771)

5- A GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 762) (SEQ. ID NO: 772)

5'- A GGG CGG CAT GGC GGG CAC AG-3' (FRAG 763) (SEQ. ID NO: 773)

5'- A GGG CGG CAT GGC GGG CAC A-3' (FRAG 764) (SEQ. ID NO: 774)

5- A GGG CGG CAT GGC GGG CAC-3' (FRAG 765) (SEQ. ED NO: 775)

5'- A GGG CGG CAT GGC GGG CA-3' (FRAG 766) (SEQ. ID NO: 776)

5'- A GGG CGG CAT GGC GGG C-3' (FRAG 767) (SEQ. ID NO: 777)

5'- A GGG CGG CAT GGC GGG -3' (FRAG 768) (SEQ. ID NO: 778)

5- A GGG CGG CAT GGC GG-3' (FRAG 769) (SEQ. ID NO: 779)

5- A GGG CGG CAT GGC G-3' (FRAG 770) (SEQ. ID NO: 780)

5'- A GGG CGG CAT GGC -3' (FRAG 771) (SEQ. ID NO: 781)

5'- A GGG CGG CAT GG -3' (FRAG 772) (SEQ. ID NO: 782)

5'- A GGG CGG CAT G -3' (FRAG 773) (SEQ. ED NO: 783)

5- A GGG CGG CAT -3' (FRAG 774) (SEQ. ID NO: 784)

5- GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 775) (SEQ. ID NO: 785)

5- GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 776) (SEQ. ID NO: 786)

5- GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 777) (SEQ. ID NO: 787)

5- GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 778) (SEQ. ED NO: 788)

5- GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 779) (SEQ. ID NO: 789)

5- GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 780) (SEQ. ID NO: 790)

5 - GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 781) (SEQ. ID NO: 791)

5'- GGG CGG CAT GGC GGG CAC AG-3' (FRAG 782) (SEQ. ID NO: 792)

5'- GGG CGG CAT GGC GGG CAC A-3' (FRAG 783) (SEQ. ID NO: 793)

5 - GGG CGG CAT GGC GGG CAC-3' (FRAG 784) (SEQ. ED NO: 794)

5 - GGG CGG CAT GGC GGG CA-3' (FRAG 785) (SEQ. ED NO: 795) - GGG CGG CAT GGC GGG C-3' (FRAG 786) (SEQ. ID NO: 796)

5- GGG CGG CAT GGC GGG -3' (FRAG 787) (SEQ. ID NO: 797) - GGG CGG CAT GGC GG-3' (FRAG 788) (SEQ. ID NO: 798) - GGG CGG CAT GGC G-3' (FRAG 789) (SEQ. ID NO: 799) - GGG CGG CAT GGC -3' (FRAG 790) (SEQ. ID NO: 800)

5'- GGG CGG CAT GG -3' (FRAG 791) (SEQ. ID NO: 801)

5 - GGG CGG CAT G -3' (FRAG 792) (SEQ. ID NO: 802)

5- GG CGG CAT GGC GGG CAC AG G CTG GGC-3' (FRAG 793) (SEQ. ID NO: 803) - GG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 794) (SEQ. ID NO: 804) - GG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 795) (SEQ. ID NO: 805) - GG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 796) (SEQ. ID NO: 806) '- GG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 797) (SEQ. ID NO: 807) '- GG CGG CAT GGC GGG CAC AGG C-3' (FRAG 798) (SEQ. ID NO: 808) - GG CGG CAT GGC GGG CAC AGG -3' (FRAG 799) (SEQ. ID NO: 809) - GG CGG CAT GGC GGG CAC AG-3' (FRAG 800) (SEQ. ID NO: 810) - GG CGG CAT GGC GGG CAC A-3' (FRAG 801) (SEQ. ID NO: 811) - GG CGG CAT GGC GGG CAC-3' (FRAG 802) (SEQ. ID NO: 812) - GG CGG CAT GGC GGG CA-3' (FRAG 803) (SEQ. ID NO: 813) '- GG CGG CAT GGC GGG C-3' (FRAG 804) (SEQ. ED NO: 814) '- GG CGG CAT GGC GGG -3' (FRAG 805) (SEQ. ID NO: 815) '- GG CGG CAT GGC GG-3' (FRAG 806) (SEQ. ID NO: 816) '- GG CGG CAT GGC G-3' (FRAG 807) (SEQ. ED NO: 817) - GG CGG CAT GGC -3' (FRAG 808) (SEQ. ED NO: 818) '- GG CGG CAT GG -3' (FRAG 809) (SEQ. ID NO: 819) - G CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 810) (SEQ. ID NO: 820) - G CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 811) (SEQ. ID NO: 821) - G CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 812) (SEQ. ID NO: 822) - G CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 813) (SEQ. ID NO: 823) - G CGG CAT GGC GGG CAC AGG CT-3' (FRAG 814) (SEQ. ID NO: 824) - G CGG CAT GGC GGG CAC AGG C-3' (FRAG 815) (SEQ. ID NO: 825) '- G CGG CAT GGC GGG CAC AGG -3' (FRAG 816) (SEQ. ID NO: 826) '- G CGG CAT GGC GGG CAC AG-3' (FRAG 817) (SEQ. ID NO: 827) '- G CGG CAT GGC GGG CAC A-3' (FRAG 818) (SEQ. ID NO: 828) - G CGG CAT GGC GGG CAC-3' (FRAG 819) (SEQ. ID NO: 829) '- G CGG CAT GGC GGG CA-3' (FRAG 820) (SEQ. ED NO: 830) - G CGG CAT GGC GGG C-3' (FRAG 821) (SEQ. ED NO: 831) - G CGG CAT GGC GGG -3' (FRAG 822) (SEQ. ID NO: 832) - G CGG CAT GGC GG-3' (FRAG 823) (SEQ. ED NO: 833) '- G CGG CAT GGC G-3' (FRAG 824) (SEQ. ED NO: 834) - G CGG CAT GGC -3' (FRAG 825) (SEQ. ID NO: 835) - CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 826) (SEQ. ED NO: 836) EPI-109 99

5- CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 827) (SEQ. ID NO: 837)

5- CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 828) (SEQ. ID NO: 838)

5- CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 829) (SEQ. ID NO: 839)

5- CGG CAT GGC GGG CAC AGG CT-3' (FRAG 830) (SEQ. ID NO: 840)

5'- CGG CAT GGC GGG CAC AGG C-3' (FRAG 831) (SEQ. ED NO: 841)

5- CGG CAT GGC GGG CAC AGG -3' (FRAG 832) (SEQ. ED NO: 842)

5'- CGG CAT GGC GGG CAC AG-3' (FRAG 833) (SEQ. ID NO: 843)

5- CGG CAT GGC GGG CAC A-3' (FRAG 834) (SEQ. ED NO: 844)

5'- CGG CAT GGC GGG CAC-3' (FRAG 835) (SEQ. ED NO: 845)

5'- CGG CAT GGC GGG CA-3' (FRAG 836) (SEQ. ED NO: 846)

5'- CGG CAT GGC GGG C-3' (FRAG 837) (SEQ. ID NO: 847)

5- CGG CAT GGC GGG -3' (FRAG 838) (SEQ. ED NO: 848)

5'- CGG CAT GGC GG-3' (FRAG 839) (SEQ. ED NO: 849)

5- CGG CAT GGC G-3' (FRAG 840) (SEQ. ED NO: 850)

5- GG CAT GGC GGG CAC AGG C TG GGC-3' (FRAG 841) (SEQ. ID NO: 851)

5- GG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 842) (SEQ. ID NO: 852)

5'- GG CAT GGC GGG CAC AGG CTG G-3' (FRAG 843) (SEQ. ID NO: 853)

5'- GG CAT GGC GGG CAC AGG CTG -3' (FRAG 844) (SEQ. ID NO: 854)

5- GG CAT GGC GGG CAC AGG CT-3' (FRAG 845) (SEQ. ID NO: 855)

5- GG CAT GGC GGG CAC AGG C-3' (FRAG 846) (SEQ. ID NO: 856)

5 - GG CAT GGC GGG CAC AGG -3' (FRAG 847) (SEQ. ID NO: 857)

5- GG CAT GGC GGG CAC AG-3' (FRAG 848) (SEQ. ID NO: 858)

5- GG CAT GGC GGG CAC A-3' (FRAG 849) (SEQ. ID NO: 859)

5'- GG CAT GGC GGG CAC-3' (FRAG 850) (SEQ. ID NO: 860)

5- GG CAT GGC GGG CA-3' (FRAG 851) (SEQ. ID NO: 861)

5- GG CAT GGC GGG C-3' (FRAG 852) (SEQ. ID NO: 862)

5'- GG CAT GGC GGG -3' (FRAG 853) (SEQ. ID NO: 863)

5- GG CAT GGC GG-3' (FRAG 854) (SEQ. ID NO: 864)

5'- G CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 855) (SEQ. ID NO: 865)

5- G CAT GGC GGG CAC AGG CTG GG-3' (FRAG 856) (SEQ. ID NO: 866)

5'- G CAT GGC GGG CAC AGG CTG G-3' (FRAG 857) (SEQ. ID NO: 867) - G CAT GGC GGG CAC AGG CTG -3' (FRAG 858) (SEQ. ID NO: 868) - G CAT GGC GGG CAC AGG CT-3' (FRAG 859) (SEQ. ID NO: 869) '- G CAT GGC GGG CAC AGG C-3' (FRAG 860) (SEQ. ID NO: 870) '- G CAT GGC GGG CAC AGG -3' (FRAG 861) (SEQ. ED NO: 871) - G CAT GGC GGG CAC AG-3' (FRAG 862) (SEQ. ID NO: 872) '- G CAT GGC GGG CAC A-3' (FRAG 863) (SEQ. ED NO: 873) - G CAT GGC GGG CAC-3' (FRAG 864) (SEQ. ID NO: 874) '- G CAT GGC GGG CA-3' (FRAG 865) (SEQ. ID NO: 875) '- G CAT GGC GGG C-3' (FRAG 866) (SEQ. ED NO: 876) - G CAT GGC GGG -3' (FRAG 867) (SEQ. ID NO: 877) - CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 868) (SEQ. ID NO: 878) - CAT GGC GGG CAC AGG CTG GG-3' (FRAG 869) (SEQ. ID NO: 879) - CAT GGC GGG CAC AGG CTG G-3' (FRAG 870) (SEQ. ID NO: 880) - CAT GGC GGG CAC AGG CTG -3' (FRAG 871) (SEQ. ID NO: 881) - CAT GGC GGG CAC AGG CT-3' (FRAG 872) (SEQ. ID NO: 882) - CAT GGC GGG CAC AGG C-3' (FRAG 873) (SEQ. ID NO: 883) - CAT GGC GGG CAC AGG -3' (FRAG 874) (SEQ. ID NO: 884) - CAT GGC GGG CAC AG-3' (FRAG 875) (SEQ. ID NO: 885) - CAT GGC GGG CAC A-3' (FRAG 876) (SEQ. ID NO: 886) - CAT GGC GGG CAC-3' (FRAG 877) (SEQ. ID NO: 887) - CAT GGC GGG CA-3' (FRAG 878) (SEQ. ED NO: 888) '- CAT GGC GGG C-3' (FRAG 879) (SEQ. ID NO: 889) - AT GGC GGG CAC AGG CTG GGC-3' (FRAG 880) (SEQ. ED NO: 890) - AT GGC GGG CAC AGG CTG GG-3' (FRAG 881) (SEQ. ED NO: 891) - AT GGC GGG CAC AGG CTG G-3' (FRAG 882) (SEQ. ID NO: 892) - AT GGC GGG CAC AGG CTG -3' (FRAG 883) (SEQ. ED NO: 893) - AT GGC GGG CAC AGG CT-3' (FRAG 884) (SEQ. ID NO: 894) '- AT GGC GGG CAC AGG C-3' (FRAG 885) (SEQ. ED NO: 895) '- AT GGC GGG CAC AGG -3' (FRAG 886) (SEQ. ED NO: 896) - AT GGC GGG CAC AG-3' (FRAG 887) (SEQ. ED NO: 897) - AT GGC GGG CAC A-3' (FRAG 888) (SEQ. ED NO: 898) '- AT GGC GGG CAC-3' (FRAG 889) (SEQ. ED NO: 899) - AT GGC GGG CA-3' (FRAG 890) (SEQ. ED NO: 900) - T GGC GGG CAC AGG CTG GGC-3' (FRAG 891) (SEQ. ID NO: 901) - T GGC GGG CAC AGG CTG GG-3' (FRAG 892) (SEQ. ED NO: 902) - T GGC GGG CAC AGG CTG G-3' (FRAG 893) (SEQ. ID NO: 903) '- T GGC GGG CAC AGG CTG -3' (FRAG 894) (SEQ. ID NO: 904) - T GGC GGG CAC AGG CT-3' (FRAG 895) (SEQ. ED NO: 905) EPI-109 100

5- T GGC GGG CAC AGG C-3' (FRAG 896) (SEQ. ID NO: 906)

5'- T GGC GGG CAC AGG -3' (FRAG 897) (SEQ. ED NO: 907)

5- T GGC GGG CAC AG-3' (FRAG 898) (SEQ. ID NO: 908)

5- T GGC GGG CAC A-3' (FRAG 899) (SEQ. ID NO: 909)

5- T GGC GGG CAC-3' (FRAG 900) (SEQ. ID NO: 910)

5- GGC GGG CAC AGG CTG GGC-3' (FRAG 901) (SEQ. ID NO: 911)

5'- GGC GGG CAC AGG CTG GG-3' (FRAG 902) (SEQ. ID NO: 912)

5- GGC GGG CAC AGG CTG G-3' (FRAG 903) (SEQ. ID NO: 913)

5- GGC GGG CAC AGG CTG -3' (FRAG 904) (SEQ. ID NO: 914)

5'- GGC GGG CAC AGG CT-3' (FRAG 905) (SEQ. ID NO: 915)

5- GGC GGG CAC AGG C-3' (FRAG 906) (SEQ. ID NO: 916)

5'- GGC GGG CAC AGG -3' (FRAG 907) (SEQ. ED NO: 917)

5 - GGC GGG CAC AG-3' (FRAG 908) (SEQ. ID NO: 918)

5- GGC GGG CAC A-3' (FRAG 909) (SEQ. ID NO: 919)

5- GC GGG CAC AGG CTG GGC-3' (FRAG 910) (SEQ. ID NO: 920)

5'- GC GGG CAC AGG CTG GG-3' (FRAG 911) (SEQ. ID NO: 921)

5'- GC GGG CAC AGG CTG G-3' (FRAG 912) (SEQ. ID NO: 922)

5- GC GGG CAC AGG CTG -3' (FRAG 913) (SEQ. ED NO: 923)

5- GC GGG CAC AGG CT-3' (FRAG 914) (SEQ. ID NO: 924)

5- GC GGG CAC AGG C-3' (FRAG 915) (SEQ. ID NO: 925)

5 - GC GGG CAC AGG -3' (FRAG 916) (SEQ. ID NO: 926)

5'- GC GGG CAC AG-3' (FRAG 917) (SEQ. ID NO: 927)

5'- C GGG CAC AGG CTG GGC-3' (FRAG 918) (SEQ. ED NO: 928)

5'- GGG CAC AGG CTG GG-3' (FRAG 919) (SEQ. ID NO: 929)

5 - C GGG CAC AGG CTG G-3' (FRAG 920) (SEQ. ID NO: 930)

5'- C GGG CAC AGG CTG -3' (FRAG 921) (SEQ. ID NO: 931)

5'- C GGG CAC AGG CT-3' (FRAG 922) (SEQ. ID NO: 932)

5'- C GGG CAC AGG C-3' (FRAG 923) (SEQ. ID NO: 933)

5- C GGG CAC AGG -3' (FRAG 924) (SEQ. ID NO: 934)

5'- GGG CAC AGG CTG GGC-3' (FRAG 925) (SEQ. ID NO: 935)

5 - GGG CAC AGG CTG GG-3' (FRAG 926) (SEQ. ID NO: 936)

5'- GGG CAC AGG CTG G-3' (FRAG 927) (SEQ. ID NO: 937)

5'- GGG CAC AGG CTG -3' (FRAG 928) (SEQ. ID NO: 938)

5'- GGG CAC AGG CT-3' (FRAG 929) (SEQ. ID NO: 939)

5'- GGG CAC AGG C-3' (FRAG 930) (SEQ. ID NO: 940)

5'- GG CAC AGG CTG GGC-3' (FRAG 931) (SEQ. ID NO: 941)

5'- GG CAC AGG CTG GG-3' (FRAG 932) (SEQ. ID NO: 942)

5- GG CAC AGG CTG G-3' (FRAG 933) (SEQ. ID NO: 943)

5'-GG CAC AGG CTG -3' (FRAG 934) (SEQ. ID NO: 944)

5'- GG CAC AGG CT-3' (FRAG 935) (SEQ. ED NO: 945)

5'-G CAC AGG CTG GGC-3' (FRAG 936) (SEQ. ID NO: 946)

5'-G CAC AGG CTG GG-3' (FRAG 937) (SEQ. ID NO: 947)

5-G CAC AGG CTG G-3' (FRAG 938) (SEQ. ID NO: 948)

5-G CAC AGG CTG -3' (FRAG 939) (SEQ. ID NO: 949)

₅'-CAC AGG CTG GGC-3' (FRAG 940) (SEQ. ID NO: 950)

5'-CAC AGG CTG GG-3' (FRAG 941) (SEQ. ID NO: 951)

5'-CAC AGG CTG G-3' (FRAG 942) (SEQ. ID NO: 952)

5'-AC AGG CTG GGC-3' (FRAG 943) (SEQ. ID NO: 953)

5-AC AGG CTG GG-3' (FRAG 944) (SEQ. ID NO: 954)

5-C AGG CTG GGC-3' (FRAG 945) (SEQ. ID NO: 955)

5'-TTT TCC TTC CTT TGT CTC TCT TC (FRAG 946) (SEQ. ID NO: 956)

5'-GCT CCC GGC TGC CTG (FRAG 947) (SEQ. ID NO: 957)

5'-CTC GGC CGT GCG GCT CTG TCG CTC CCG GT (FRAG 948) (SEQ. ID NO: 958)

5'-CCG CCG CCC TCC GGG GGG TC (FRAG 949) (SEQ. ID NO: 959)

5'-TGC TGC CGT TGG CTG CCC (FRAG 950) (SEQ. ID NO: 960)

5'-CTT CTG CGG GTC GCC GG (FRAG 951) (SEQ. ID NO: 961)

5'-TGC TGG GCT TGT GGC O^RAG 952) (SEQ. ED NO: 962)

5'-GGC CTC TCT TCT GGG (FRAG 953) (SEQ. ID NO: 963)

5'-CCT GGT CCC TCC GT (FRAG 954) (SEQ. ED NO: 964)

5'-GGT GGC TCC TCT GC (FRAG 955) (SEQ. ID NO: 965)

5'-GCT TGG TCC TGG GGC TGC (FRAG 956) (SEQ. ID NO: 966)

5'-TGC TCT CCT CTC CTT (FRAG 957) (SEQ. ED NO: 967)

Human Adenosine A2a Receptor Nucleic Acid and Antisense Oligonucleotide Fragments

5'-TGC TTT TCT TTT CTG GGC CTC TGT GGT CTG TTT TTT TCT G GCC CTG CTG GGG CGC TCT CC GCC GCC CGC CTG GCT CCC GGB GCC CBT GBT GGG CBT GCC GTG GTT CTT GCC CTC CTT TGG CTG CCG TGC CCG CTC CCC GGC CTC CTG GCG GGT GGC CGT TG GGC CCG TGT TCC CCT GGG -GCC TGG GGC TCC CTT CTC TC GCC CTT CTT GCT GGG CCT C TGC TGC TGC TGG TGC TGT GGC CCC C GTA CAC CGA GGA GCC CAT GAT GGG CAT GCC ACA GAC GAC AGG C GTB CBC CGB GGB GCC CBT GBT GGG CBT GCC BCB GBC GBC BGG C-3' (FRAG. NO.1665) (SEQ. ID NO:1678) 5'-CTG GGC CTC-3' (FRAG 1666) (SEQ. ED NO: 1679) bPI-109 101

5'-GCC GCC CGC CTG-3' (FRAG 1667) (SEQ. ID NO: 1680)

5 -GC CCG CTC CCC GGC-3' (FRAG 1668) (SEQ. ED NO: 1681)

5 -CBCCGBGGBGCCC-3' (FRAG 1669) (SEQ. ED NO: 1682)

5'-TGC TTT TCT TTT CTG GGC CTC-3' (FRAG 958) (SEQ. ED NO: 968)

5'-TGT GGT CTG TTT TTT TCT G-3' (FRAG 959) (SEQ. ED NO: 969)

5'-GCC CTG CTG GGG CGC TCT CC-3' (FRAG 960) (SEQ. ID NO: 970)

5'-GCC GCC CGC CTG GCT CCC-3' (FRAG 961) (SEQ. ID NO: 971)

5'-GGB GCC CBT GBT GGG CBT GCC-3' (FRAG 962) (SEQ. ED NO: 972)

5'-GTG GTT CTT GCC CTC CTT TGG CTG-3' (FRAG 963) (SEQ. ID NO: 973)

5'-CCG TGC CCG CTC CCC GGC-3' (FRAG 964) (SEQ. ED NO: 974)

5'-CTC CTG GCG GGT GGC CGT TG-3' (FRAG 965) (SEQ. ED NO: 975)

5'-GGC CCG TGT TCC CCT GGG-3' (FRAG 966) (SEQ. ED NO: 976)

S'-GCC TGG GGC TCC CTT CTC TC-3' (FRAG 967) (SEQ. ID NO: 977)

5'-GCC CTT CTT GCT GGG CCT C-3' (FRAG 968) (SEQ. ID NO: 978)

5'-TGC TGC TGC TGG TGC TGT GGC CCC C-3' (FRAG 969) (SEQ. ID NO: 979)

5'-GTACACCGAGGAGCCCATGATGGGCATGCCACAGACGACAGGC-3' (FRAG 970) (SEQ. ID NO: 980)

5 -GTBCBCCGBGGBGCCCBTGBTGGGCBTGCCBCBGBCGBCBGGC-3' (FRAG 971) (SEQ. ID NO: 981)

Human Adenosine A2b Receptor Nucleic Acid and Antisense Oligonucleotide Fragments

5 -GGC GCC GTG CCG CGT CTT GGT GGC GGC GG GTT CGC GCC CGC GCG GGG CCC CTC CGG TCC GTT CGC GCC CGC GCG GGG CCC CTC CGG TCC CGG GTC GGG GCC CCC CGC GGC C GCC TCG GGG CTG GGG CGC TGG TGG CCG GG CCG CGC CTC CGC CTG CCG CTT CTG GCT GGG CCC CGG GCG CCC CCT CCC CTC TTG CTC GGG TCC CCG TG ACA GCG CGT CCT GTG TCT CCA GCA GCA TGG CCG GGC CAG CTG GGC CCC BCB GCG CGT CCT GTG TCT CCB GCB GCB TGG CCG GGC CBG CTG GGC CCC CCCAGCCCCG AGGCTCAGAA GCGGCAGGCG GAGGCGCGGT CCGGGCGCTA TGGCCATGCC CGGCGGGTCT CACGCGGCTG CCCCTCGCCC GGCGCGCCTT CGGTAGGGGG CGCCCGGGGC CCAGCTGGCC CGGCCATGCT GCTGGAGACA CAGGACGCGC TGTACGTGGC GCTGGAGCTG GTCATCGCCG CGCTTTCGGT GGCGGGCAAC GTGCTGGTGT GCGCCGCGGT GGGCACGGCG AACACTCTGC AGACGCCCAC CAACTACTTC CTGGTGTCCC TGGCTGCGGC CGACGTGGCC GTGGGGCTCT TCGCCATCCC CTTTGCCATC ACCATCAGCC TGGGCTTCTG CACTGACTTC TACGGCTGCC TCTTCCTCGC CTGCTTCGTG CTGGTGCTCA CGCAGAGCTC CATCTTCAGC CTTCTGGCCG TGGCAGTCGA CAGATACCTG GCCATCTGTG TCCCGCTCAG GTATAAAAGT TTGGTCACGG GGACCCGAGC AAGAGGGGTC ATTGCTGTCC TCTGGGTCCT TGCCTTTGGC ATCGGATTGA CTCCATTCCT GGGGTGGAAC AGTAAAGACA GTGCCACCAA CAACTGCACA GAACCCTGGG ATGGAACCAC GAATGAAAGC TGCTGCCTTG TGAAGTGTCT CTTTGAGAAT GTGGTCCCCA TGAGCTACAT GGTATATTTC AATTTCTTTG GGTGTGTTCT GCCCCCACTG CTTATAATGC TGGTGATCTA CATTAAGATC TTCCTGGTGG CCTGCAGGCA GCTTCAGCGC ACTGAGCTGA TGGACCACTC GAGGACCACC CTCCAGCGGG AGATCCATGC AGCCAAGTCA CTGGCCATGA TTGTGGGGAT TTTTGCCCTG TGCTGGTTAC CTGTGCATGC TGTTAACTGT GTCACTCTTT TCCAGCCAGC TCAGGGTAAA AATAAGCCCA AGTGGGCAAT GAATATGGCC ATTCTTCTGT CACATGCCAA TTCAGTTGTC AATCCCATTG TCTATGCTTA CCGGAACCGA GACTTCCGCT ACACTTTTCA CAAAATTATC TCCAGGTATC TTCTCTGCCA AGCAGATGTC AAGAGTGGGA ATGGTCAGGC TGGGGTACAG CCTGCTCTCG GTGTGGGCCT ATGATCTAGG CTCTCGCCTC TTCCAGGAGA AGATACAAAT CCACAAGAAA CAAAGAGGAC ACGGCTGGTT TTCATTGTGA AAGATAGCTA CACCTCACAA GGAAATGGAC TGCCTCTCTT GAGCACTTCC CTGGAGCTAC CACGTATCTA GCTAATATGT ATGTGTCAGT AGTAGCACCA AGGATTGACA AATATATTTA TGATCTATTC AGCTGCTTTT ACTGTGTGGA TTATGCCAAC AGCTTGAATG GATTCTAACA GACTCTTTTG TTTTTAAAAG TCTGCCTTGT TTATGGTGGA AAATTACTGA AACTATTTTA CTGTGAAACA GTGTGAACTA TTATAATGCA AATACTTTTT AACTTAGAGG CAATGGAAAA ATAAAAGTTG ACTGTACTAA AAATGTATAC TTGTTGCCAG GAAGGTGACC TCAAAAATTA AAAGTATAAT TATTCGGCCG GGCATGGTGG CTCACACCTG TAATTCCAGC ACTTTGGGAG GCCAAGGCAG GCGGATCACG AGGTCAGGAG TTCAAAACCA GCCTGTCCAA TATAGTG GGGCAATTTG TTAGTTATCC GCCGCCACCA AGACGCGGCA CGGCGCCTGG ACCGGAGGGG CCCCGCGCGG GCGCGAACTT TGGGCTCGGG CGAGTGGGTG GTGCTCCGCC CAGCCCGAGA CGGGCGGGCG CGCGGGCCAA TGGGTGCCGC CTCTTGGCCG CGGGGGGCCC CGACCCGTGG GTCCCGGCCA CCAGCGCCCC AGCCCCGAGG CTCAGAAGCG GCAGGCGGAG GCGCGGTCCG GGCGCTATGG CCATGCCCGG CGGGTCTCAC GCGGCTGCCC CTCGCCCGGC GCGCCTTCGG TAGGGGGCGC CCGGGGCCCA GCTGGCCCGG CCATGCTGCT GGAGACACAG GACGCGCTGT ACGTGGCGCT GGAGCTGGTC ATCGCCGCGC TTTCGGTGGC GGGCAACGTG CTGGTGTGCG CCGCGGTGGG CACGGCGAAC ACTCTGCAGA CGCCCACCAA CTACTTCCTG GTGTCCCTGG CTGCGGCCGA CGTGGCCGTG GGGCTCTTCG CCATCCCCTT TGCCATCACC ATCAGCCTGG GCTTCTGCAC TGACTTCTAC GGCTGCCTCT TCCTCGCCTG CTTCGTGCTG GTGCTCACGC AGAGCTCCAT CTTCAGCCTT CTGGCCGTGG CAGTCGACAG ATACCTGGCC ATCTGTGTCC CGCTCAGGTA TAAAAGTTTG GTCACGGGGA CCCGAGCAAG AGGGGTCATT GCTGTCCTCT GGGTCCTTGC CTTTGGCATC GGATTGACTC CATTCCTGGG GTGGAACAGT AAAGACAGTG CCACCAACAA CTGCACAGAA CCCTGGGATG GAACCACGAA TGAAAGCTGC TGCCTTGTGA AGTGTCTCTT TGAGAATGTG GTCCCCATGA GCTACATGGT ATATTTCAAT TTCTTTGGGT GTGTTCTGCC CCCACTGCTT ATAATGCTGG TGATCTACAT TAAGATCTTC CTGGTGGCCT GCAGGCAGCT TCAGCGCACT GAGCTGATGG ACCACTCGAG GACCACCCTC CAGCGGGAGA TCCATGCAGC CAAGTCACTG GCCATGATTG TGGGGATTTT TGCCCTGTGC TGGTTACCTG TGCATGCTGT TAACTGTGTC ACTCTTTTCC AGCCAGCTCA GGGTAAAAAT AAGCCCAAGT GGGCAATGAA TATGGCCATT CTTCTGTCAC ATGCCAATTC AGTTGTCAAT CCCATTGTCT ATGCTTACCG GAACCGAGAC TTCCGCTACA CTTTTCACAA AATTATCTCC AGGTATCTTC TCTGCCAAGC AGATGTCAAG AGTGGGAATG GTCAGGCTGG GGTACAGCCT GCTCTCGGTG TGGGCCTATG ATCTAGGCTC TCGCCTCTTC CAGGAGAAGA TACAAATCCA CAAGAAACAA AGAGGACACG GCTGGTTTTC ATTGTGAAAG ATAGCTACAC CTCACAAGGA AATGGACTGC CTCTCTTGAG CACTTCCCTG GAGCTACCAC GTATCTAGCT AATATGTATG TGTCAGTAGT AGGCTCCAAG GATTGACAAA TATATTTATG ATCTATTCAG CTGCTTTTAC TGTGTGGATT ATGCCAACAG CTTGAATGGA TTCTAACAGA CTCTTTTGTT TTTAAAAGTC TGCCTTGTTT ATGGTGGAAA ATTACTGAAA CTATTTTACT GTGAAACAGT GTGAACTATT ATAATGCAAA TACTTTTTAA CTTAGAGGCA ATGGAAAAAT AAAAGTTGAC TGTACTAAAA EPI-109 102

ATG CCCAGCCCCG AGGCTCAGAA GCGGCAGGCG GAGGCGCGGT CCGGGCGCTA TGGCCATGCC CGGCGGGTCT CACGCGGCTG CCCCTCGCCC GGCGCGCCTT CGGTAGGGGG CGCCCGGGGC CCAGCTGGCC CGGCCATGCT GCTGGAGACA CAGGACGCGC TGTACGTGGC GCTGGAGCTG GTCATCGCCG CGCTTTCGGT GGCGGGCAAC GTGCTGGTGT GCGCCGCGGT GGGCACGGCG AACACTCTGC AGACGCCCAC CAACTACTTC CTGGTGTCCC TGGCTGCGGC CGACGTGGCC GTGGGGCTCT TCGCCATCCC CTTTGCCATC ACCATCAGCC TGGGCTTCTG CACTGACTTC TACGGCTGCC TCTTCCTCGC CTGCTTCGTG CTGGTGCTCA CGCAGAGCTC CATCTTCAGC CTTCTGGCCG TGGCAGTCGA CAGATACCTG GCCATCTGTG TCCCGCTCAG GTATAAAAGT TTGGTCACGG GGACCCGAGC AAGAGGGGTC ATTGCTGTCC TCTGGGTCCT TGCCTTTGGC ATCGGATTGA CTCCATTCCT GGGGTGGAAC AGTAAAGACA GTGCCACCAA CAACTGCACA GAACCCTGGG ATGGAACCAC GAATGAAAGC TGCTGCCTTG TGAAGTGTCT CTTTGAGAAT GTGGTCCCCA TGAGCTACAT GGTATATTTC AATTTCTTTG GGTGTGTTCT GCCCCCACTG CTTATAATGC TGGTGATCTA CATTAAGATC TTCCTGGTGG CCTGCAGGCA GCTTCAGCGC ACTGAGCTGA TGGACCACTC GAGGACCACC CTCCAGCGGG AGATCCATGC AGCCAAGTCA CTGGCCATGA TTGTGGGGAT TTTTGCCCTG TGCTGGTTAC CTGTGCATGC TGTTAACTGT GTCACTCTTT TCCAGCCAGC TCAGGGTAAA AATAAGCCCA AGTGGGCAAT GAATATGGCC ATTCTTCTGT CACATGCCAA TTCAGTTGTC AATCCCATTG TCTATGCTTA CCGGAACCGA GACTTCCGCT ACACTTTTCA CAAAATTATC TCCAGGTATC TTCTCTGCCA AGCAGATGTC AAGAGTGGGA ATGGTCAGGC TGGGGTACAG CCTGCTCTCG GTGTGGGCCT ATGATCTAGG CTCTCGCCTC TTCCAGGAGA AGATACAAAT CCACAAGAAA CAAAGAGGAC ACGGCTGGTT TTCATTGTGA AAGATAGCTA CACCTCACAA GGAAATGGAC TGCCTCTCTT GAGCACTTCC CTGGAGCTAC CACGTATCTA GCTAATATGT ATGTGTCAGT AGTAGCACCA AGGATTGACA AATATATTTA TGATCTATTC AGCTGCTTTT ACTGTGTGGA TTATGCCAAC AGCTTGAATG GATTCTAACA GACTCTTTTG TTTTTAAAAG TCTGCCTTGT TTATGGTGGA AAATTACTGA AACTATTTTA CTGTGAAACA GTGTGAACTA TTATAATGCA AATACTTTTT AACTTAGAGG CAATGGAAAA ATAAAAGTTG ACTGTACTAA AAATGTATAC TTGTTGCCAG GAAGGTGACC TCAAAAATTA AAAGTATAAT TATTCGGCCG GGCATGGTGG CTCACACCTG TAATTCCAGC ACTTTGGGAG GCCAAGGCAG GCGGATCACG AGGTCAGGAG TTCAAAACCA GCCTGTCCAA TATAGTG GGGCAATTTG TTAGTTATCC GCCGCCACCA AGACGCGGCA CGGCGCCTGG ACCGGAGGGG CCCCGCGCGG GCGCGAACTT TGGGCTCGGG CGAGTGGGTG GTGCTCCGCC CAGCCCGAGA CGGGCGGGCG CGCGGGCCAA TGGGTGCCGC CTCTTGGCCG CGGGGGGCCC CGACCCGTGG GTCCCGGCCA CCAGCGCCCC AGCCCCGAGG CTCAGAAGCG GCAGGCGGAG GCGCGGTCCG GGCGCTATGG CCATGCCCGG CGGGTCTCAC GCGGCTGCCC CTCGCCCGGC GCGCCTTCGG TAGGGGGCGC CCGGGGCCCA GCTGGCCCGG CCATGCTGCT GGAGACACAG GACGCGCTGT ACGTGGCGCT GGAGCTGGTC ATCGCCGCGC TTTCGGTGGC GGGCAACGTG CTGGTGTGCG CCGCGGTGGG CACGGCGAAC ACTCTGCAGA CGCCCACCAA CTACTTCCTG GTGTCCCTGG CTGCGGCCGA CGTGGCCGTG GGGCTCTTCG CCATCCCCTT TGCCATCACC ATCAGCCTGG GCTTCTGCAC TGACTTCTAC GGCTGCCTCT TCCTCGCCTG CTTCGTGCTG GTGCTCACGC AGAGCTCCAT CTTCAGCCTT CTGGCCGTGG CAGTCGACAG ATACCTGGCC ATCTGTGTCC CGCTCAGGTA TAAAAGTTTG GTCACGGGGA CCCGAGCAAG AGGGGTCATT GCTGTCCTCT GGGTCCTTGC CTTTGGCATC GGATTGACTC CATTCCTGGG GTGGAACAGT AAAGACAGTG CCACCAACAA CTGCACAGAA CCCTGGGATG GAACCACGAA TGAAAGCTGC TGCCTTGTGA AGTGTCTCTT TGAGAATGTG GTCCCCATGA GCTACATGGT ATATTTCAAT TTCTTTGGGT GTGTTCTGCC CCCACTGCTT ATAATGCTGG TGATCTACAT TAAGATCTTC CTGGTGGCCT GCAGGCAGCT TCAGCGCACT GAGCTGATGG ACCACTCGAG GACCACCCTC CAGCGGGAGA TCCATGCAGC CAAGTCACTG GCCATGATTG TGGGGATTTT TGCCCTGTGC TGGTTACCTG TGCATGCTGT TAACTGTGTC ACTCTTTTCC AGCCAGCTCA GGGTAAAAAT AAGCCCAAGT GGGCAATGAA TATGGCCATT CTTCTGTCAC ATGCCAATTC AGTTGTCAAT CCCATTGTCT ATGCTTACCG GAACCGAGAC TTCCGCTACA CTTTTCACAA AATTATCTCC AGGTATCTTC TCTGCCAAGC AGATGTCAAG AGTGGGAATG GTCAGGCTGG GGTACAGCCT GCTCTCGGTG TGGGCCTATG ATCTAGGCTC TCGCCTCTTC CAGGAGAAGA TACAAATCCA CAAGAAACAA AGAGGACACG GCTGGTTTTC ATTGTGAAAG ATAGCTACAC CTCACAAGGA AATGGACTGC CTCTCTTGAG CACTTCCCTG GAGCTACCAC GTATCTAGCT AATATGTATG TGTCAGTAGT AGGCTCCAAG GATTGACAAA TATATTTATG ATCTATTCAG CTGCTTTTAC TGTGTGGATT ATGCCAACAG CTTGAATGGA TTCTAACAGA CTCTTTTGTT TTTAAAAGTC TGCCTTGTTT ATGGTGGAAA ATTACTGAAA CTATTTTACT GTGAAACAGT GTGAACTATT ATAATGCAAA TACTTTTTAA CTTAGAGGCA ATGGAAAAAT AAAAGTTGAC TGTACTAAAA ATG -3' (FRAG. NO: 1670) (SEQ. ID NO:1683)

5'- GGGCAATTTG TTAGTTATCC GCCGCCACCA AGACGCGGCA CGGCGCCTGG ACCGGAGGGG CCCCGCGCGG GCGCGAACTT TGGGCTCGGG CGAGTGGGTG GTGCTCCGCC CAGCCCGAGA CGGGCGGGCG CGCGGGCCAA TGGGTGCCGC CTCTTGGCCG CGGGGGGCCC CGACCCGTGG GTCCCGGCCA CCAGCGCCCC AGCCCCGAGG CTCAGAAGCG GCAGGCGGAG GCGCGGTCCG GGCGCTATGG CCATGCCCGG CGGGTCTCAC GCGGCTGCCC CTCGCCCGGC GCGCCTTCGG TAGGGGGCGC CCGGGGCCCA GCTGGCCCGG CCATGCTGCT GGAGACACAG GACGCGCTGT ACGTGGCGCT GGAGCTGGTC ATCGCCGCGC TTTCGGTGGC GGGCAACGTG CTGGTGTGCG CCGCGGTGGG CACGGCGAAC ACTCTGCAGA CGCCCACCAA CTACTTCCTG GTGTCCCTGG CTGCGGCCGA CGTGGCCGTG GGGCTCTTCG CCATCCCCTT TGCCATCACC ATCAGCCTGG GCTTCTGCAC TGACTTCTAC GGCTGCCTCT TCCTCGCCTG CTTCGTGCTG GTGCTCACGC AGAGCTCCAT CTTCAGCCTT CTGGCCGTGG CAGTCGACAG ATACCTGGCC ATCTGTGTCC CGCTCAGGTA TAAAAGTTTG GTCACGGGGA CCCGAGCAAG AGGGGTCATT GCTGTCCTCT GGGTCCTTGC CTTTGGCATC GGATTGACTC CATTCCTGGG GTGGAACAGT AAAGACAGTG CCACCAACAA CTGCACAGAA CCCTGGGATG GAACCACGAA TGAAAGCTGC TGCCTTGTGA AGTGTCTCTT TGAGAATGTG GTCCCCATGA GCTACATGGT ATATTTCAAT TTCTTTGGGT GTGTTCTGCC CCCACTGCTT ATAATGCTGG TGATCTACAT TAAGATCTTC CTGGTGGCCT GCAGGCAGCT TCAGCGCACT GAGCTGATGG ACCACTCGAG GACCACCCTC CAGCGGGAGA TCCATGCAGC CAAGTCACTG GCCATGATTG TGGGGATTTT TGCCCTGTGC TGGTTACCTG TGCATGCTGT TAACTGTGTC ACTCTTTTCC AGCCAGCTCA GGGTAAAAAT AAGCCCAAGT GGGCAATGAA TATGGCCATT CTTCTGTCAC ATGCCAATTC AGTTGTCAAT CCCATTGTCT ATGCTTACCG GAACCGAGAC TTCCGCTACA CTTTTCACAA AATTATCTCC AGGTATCTTC TCTGCCAAGC AGATGTCAAG AGTGGGAATG GTCAGGCTGG GGTACAGCCT GCTCTCGGTG TGGGCCTATG ATCTAGGCTC TCGCCTCTTC CAGGAGAAGA TACAAATCCA CAAGAAACAA AGAGGACACG GCTGGTTTTC ATTGTGAAAG ATAGCTACAC CTCACAAGGA AATGGACTGC CTCTCTTGAG CACTTCCCTG GAGCTACCAC GTATCTAGCT AATATGTATG TGTCAGTAGT AGGCTCCAAG GATTGACAAA TATATTTATG ATCTATTCAG CTGCTTTTAC TGTGTGGATT ATGCCAACAG CTTGAATGGA TTCTAACAGA CTCTTTTGTT TTTAAAAGTC TGCCTTGTTT ATGGTGGAAA ATTACTGAAA CTATTTTACT GTGAAACAGT GTGAACTATT ATAATGCAAA TACTTTTTAA CTTAGAGGCA ATGGAAAAAT AAAAGTTGAC TGTACTAAAA ATG -3' (FRAG. NO: ) (SEQ. ID bPI-109 103

NO:2436)

5'- CCCAGCCCCG AGGCTCAGAA GCGGCAGGCG GAGGCGCGGT CCGGGCGCTA TGGCCATGCC CGGCGGGTCT CACGCGGCTG CCCCTCGCCC GGCGCGCCTT CGGTAGGGGG CGCCCGGGGC CCAGCTGGCC CGGCCATGCT GCTGGAGACA CAGGACGCGC TGTACGTGGC GCTGGAGCTG GTCATCGCCG CGCTTTCGGT GGCGGGCAAC GTGCTGGTGT GCGCCGCGGT GGGCACGGCG AACACTCTGC AGACGCCCAC CAACTACTTC CTGGTGTCCC TGGCTGCGGC CGACGTGGCC GTGGGGCTCT TCGCCATCCC CTTTGCCATC ACCATCAGCC TGGGCTTCTG CACTGACTTC TACGGCTGCC TCTTCCTCGC CTGCTTCGTG CTGGTGCTCA CGCAGAGCTC CATCTTCAGC CTTCTGGCCG TGGCAGTCGA CAGATACCTG GCCATCTGTG TCCCGCTCAG GTATAAAAGT TTGGTCACGG GGACCCGAGC AAGAGGGGTC ATTGCTGTCC TCTGGGTCCT TGCCTTTGGC ATCGGATTGA CTCCATTCCT GGGGTGGAAC AGTAAAGACA GTGCCACCAA CAACTGCACA GAACCCTGGG ATGGAACCAC GAATGAAAGC TGCTGCCTTG TGAAGTGTCT CTTTGAGAAT GTGGTCCCCA TGAGCTACAT GGTATATTTC AATTTCTTTG GGTGTGTTCT GCCCCCACTG CTTATAATGC TGGTGATCTA CATTAAGATC TTCCTGGTGG CCTGCAGGCA GCTTCAGCGC ACTGAGCTGA TGGACCACTC GAGGACCACC CTCCAGCGGG AGATCCATGC AGCCAAGTCA CTGGCCATGA TTGTGGGGAT TTTTGCCCTG TGCTGGTTAC CTGTGCATGC TGTTAACTGT GTCACTCTTT TCCAGCCAGC TCAGGGTAAA AATAAGCCCA AGTGGGCAAT GAATATGGCC ATTCTTCTGT CACATGCCAA TTCAGTTGTC AATCCCATTG TCTATGCTTA CCGGAACCGA GACTTCCGCT ACACTTTTCA CAAAATTATC TCCAGGTATC TTCTCTGCCA AGCAGATGTC AAGAGTGGGA ATGGTCAGGC TGGGGTACAG CCTGCTCTCG GTGTGGGCCT ATGATCTAGG CTCTCGCCTC TTCCAGGAGA AGATACAAAT CCACAAGAAA CAAAGAGGAC ACGGCTGGTT TTCATTGTGA AAGATAGCTA CACCTCACAA GGAAATGGAC TGCCTCTCTT GAGCACTTCC CTGGAGCTAC CACGTATCTA GCTAATATGT ATGTGTCAGT AGTAGCACCA AGGATTGACA AATATATTTA TGATCTATTC AGCTGCTTTT ACTGTGTGGA TTATGCCAAC AGCTTGAATG GATTCTAACA GACTCTTTTG TTTTTAAAAG TCTGCCTTGT TTATGGTGGA AAATTACTGA AACTATTTTA CTGTGAAACA GTGTGAACTA TTATAATGCA AATACTTTTT AACTTAGAGG CAATGGAAAA ATAAAAGTTG ACTGTACTAA AAATGTATAC TTGTTGCCAG GAAGGTGACC TCAAAAATTA AAAGTATAAT TATTCGGCCG GGCATGGTGG CTCACACCTG TAATTCCAGC ACTTTGGGAG GCCAAGGCAG GCGGATCACG AGGTCAGGAG TTCAAAACCA GCCTGTCCAA TATAGTG -3' (FRAG. NO:_) (SEQ. ID NO:2435)

5'- GGGCAATTTG TTAGTTATCC GCCGCCACCA AGACGCGGCA CGGCGCCTGG ACCGGAGGGG CCCCGCGCGG GCGCGAACTT TGGGCTCGGG CGAGTGGGTG GTGCTCCGCC CAGCCCGAGA CGGGCGGGCG CGCGGGCCAA TGGGTGCCGC CTCTTGGCCG CGGGGGGCCC CGACCCGTGG GTCCCGGCCA CCAGCGCCCC AGCCCCGAGG CTCAGAAGCG GCAGGCGGAG GCGCGGTCCG GGCGCTATGG CCATGCCCGG CGGGTCTCAC GCGGCTGCCC CTCGCCCGGC GCGCCTTCGG TAGGGGGCGC CCGGGGCCCA GCTGGCCCGG CCATGCTGCT GGAGACACAG GACGCGCTGT ACGTGGCGCT GGAGCTGGTC ATCGCCGCGC TTTCGGTGGC GGGCAACGTG CTGGTGTGCG CCGCGGTGGG CACGGCGAAC ACTCTGCAGA CGCCCACCAA CTACTTCCTG GTGTCCCTGG CTGCGGCCGA CGTGGCCGTG GGGCTCTTCG CCATCCCCTT TGCCATCACC ATCAGCCTGG GCTTCTGCAC TGACTTCTAC GGCTGCCTCT TCCTCGCCTG CTTCGTGCTG GTGCTCACGC AGAGCTCCAT CTTCAGCCTT CTGGCCGTGG CAGTCGACAG ATACCTGGCC ATCTGTGTCC CGCTCAGGTA TAAAAGTTTG GTCACGGGGA CCCGAGCAAG AGGGGTCATT GCTGTCCTCT GGGTCCTTGC CTTTGGCATC GGATTGACTC CATTCCTGGG GTGGAACAGT AAAGACAGTG CCACCAACAA CTGCACAGAA CCCTGGGATG GAACCACGAA TGAAAGCTGC TGCCTTGTGA AGTGTCTCTT TGAGAATGTG GTCCCCATGA GCTACATGGT ATATTTCAAT TTCTTTGGGT GTGTTCTGCC CCCACTGCTT ATAATGCTGG TGATCTACAT TAAGATCTTC CTGGTGGCCT GCAGGCAGCT TCAGCGCACT GAGCTGATGG ACCACTCGAG GACCACCCTC CAGCGGGAGA TCCATGCAGC CAAGTCACTG GCCATGATTG TGGGGATTTT TGCCCTGTGC TGGTTACCTG TGCATGCTGT TAACTGTGTC ACTCTTTTCC AGCCAGCTCA GGGTAAAAAT AAGCCCAAGT GGGCAATGAA TATGGCCATT CTTCTGTCAC ATGCCAATTC AGTTGTCAAT CCCATTGTCT ATGCTTACCG GAACCGAGAC TTCCGCTACA CTTTTCACAA AATTATCTCC AGGTATCTTC TCTGCCAAGC AGATGTCAAG AGTGGGAATG GTCAGGCTGG GGTACAGCCT GCTCTCGGTG TGGGCCTATG ATCTAGGCTC TCGCCTCTTC CAGGAGAAGA TACAAATCCA CAAGAAACAA AGAGGACACG GCTGGTTTTC ATTGTGAAAG ATAGCTACAC CTCACAAGGA AATGGACTGC CTCTCTTGAG CACTTCCCTG GAGCTACCAC GTATCTAGCT AATATGTATG TGTCAGTAGT AGGCTCCAAG GATTGACAAA TATATTTATG ATCTATTCAG CTGCTTTTAC TGTGTGGATT ATGCCAACAG CTTGAATGGA TTCTAACAGA CTCTTTTGTT TTTAAAAGTC TGCCTTGTTT ATGGTGGAAA ATTACTGAAA CTATTTTACT GTGAAACAGT GTGAACTATT ATAATGCAAA TACTTTTTAA CTTAGAGGCA ATGGAAAAAT AAAAGTTGAC TGTACTAAAA ATG -3' (FRAG. NO: ) (SEQ. ID NO:2425)

5'-CCCAGCCCCG AGGCTCAGAA GCGGCAGGCG GAGGCGCGGT CCGGGCGCTA TGGCCATGCC CGGCGGGTCT CACGCGGCTG CCCCTCGCCC GGCGCGCCTT CGGTAGGGGG CGCCCGGGGC CCAGCTGGCC CGGCCATGCT GCTGGAGACA CAGGACGCGC TGTACGTGGC GCTGGAGCTG GTCATCGCCG CGCTTTCGGT GGCGGGCAAC GTGCTGGTGT GCGCCGCGGT GGGCACGGCG AACACTCTGC AGACGCCCAC CAACTACTTC CTGGTGTCCC TGGCTGCGGC CGACGTGGCC GTGGGGCTCT TCGCCATCCC CTTTGCCATC ACCATCAGCC TGGGCTTCTG CACTGACTTC TACGGCTGCC TCTTCCTCGC CTGCTTCGTG CTGGTGCTCA CGCAGAGCTC CATCTTCAGC CTTCTGGCCG TGGCAGTCGA CAGATACCTG GCCATCTGTG TCCCGCTCAG GTATAAAAGT TTGGTCACGG GGACCCGAGC AAGAGGGGTC ATTGCTGTCC TCTGGGTCCT TGCCTTTGGC ATCGGATTGA CTCCATTCCT GGGGTGGAAC AGTAAAGACA GTGCCACCAA CAACTGCACA GAACCCTGGG ATGGAACCAC GAATGAAAGC TGCTGCCTTG TGAAGTGTCT CTTTGAGAAT GTGGTCCCCA TGAGCTACAT GGTATATTTC AATTTCTTTG GGTGTGTTCT GCCCCCACTG CTTATAATGC TGGTGATCTA CATTAAGATC TTCCTGGTGG CCTGCAGGCA GCTTCAGCGC ACTGAGCTGA TGGACCACTC GAGGACCACC CTCCAGCGGG AGATCCATGC AGCCAAGTCA CTGGCCATGA TTGTGGGGAT TTTTGCCCTG TGCTGGTTAC CTGTGCATGC TGTTAACTGT GTCACTCTTT TCCAGCCAGC TCAGGGTAAA AATAAGCCCA AGTGGGCAAT GAATATGGCC ATTCTTCTGT CACATGCCAA TTCAGTTGTC AATCCCATTG TCTATGCTTA CCGGAACCGA GACTTCCGCT ACACTTTTCA CAAAATTATC TCCAGGTATC TTCTCTGCCA AGCAGATGTC AAGAGTGGGA ATGGTCAGGC TGGGGTACAG CCTGCTCTCG GTGTGGGCCT ATGATCTAGG CTCTCGCCTC TTCCAGGAGA AGATACAAAT CCACAAGAAA CAAAGAGGAC ACGGCTGGTT TTCATTGTGA AAGATAGCTA CACCTCACAA GGAAATGGAC TGCCTCTCTT GAGCACTTCC CTGGAGCTAC CACGTATCTA GCTAATATGT ATGTGTCAGT AGTAGCACCA AGGATTGACA AATATATTTA TGATCTATTC AGCTGCTTTT ACTGTGTGGA TTATGCCAAC AGCTTGAATG GATTCTAACA GACTCTTTTG TTTTTAAAAG TCTGCCTTGT TTATGGTGGA AAATTACTGA AACTATTTTA CTGTGAAACA GTGTGAACTA TTATAATGCA AATACTTTTT AACTTAGAGG CAATGGAAAA ATAAAAGTTG ACTGTACTAA AAATGTATAC TTGTTGCCAG GAAGGTGACC TCAAAAATTA AAAGTATAAT TATTCGGCCG EPI-109 104

GGCATGGTGG CTCACACCTG TAATTCCAGC ACTTTGGGAG GCCAAGGCAG GCGGATCACG AGGTCAGGAG TTCAAAACCA

GCCTGTCCAA TATAGTG (FRAG. NO: _) ( SEQ. ED NO: 2424)

5 -GCGCGTCCTG-3' (FRAG. NO: 1671) (SEQ. ID NO:1684)

5 -GCT GGG CCC CGG-3' (FRAG. NO: 1672) (SEQ. ED NO:1685)

5 -CGG GTC GGG GCC CCC C-3' (FRAG. NO: 1673) (SEQ. ED NO:1686)

5 - CGC GCC CGC G-3' (FRAG. NO: 1674) (SEQ. ED NO:1687)

5'-GGC GCC GTG CCG CGT CTT GGT GGC GGC GG-3' (FRAG 972) (SEQ. ED NO: 982)

S'-GTT CGC GCC CGC GCG GGG CCC CTC CGG TCC-3' (FRAG 973) (SEQ. ID NO: 983)

5'-GTT CGC GCC CGC GCG GGG CCC CTC CGG TCC-3' (FRAG 974) (SEQ. ID NO: 984)

5'-CGG GTC GGG GCC CCC CGC GGC C-3' (FRAG 975) (SEQ. ED NO: 985)

5'-GCC TCG GGG CTG GGG CGC TGG TGG CCG GG-3' (FRAG 976) (SEQ. ED NO: 986)

5'-CCG CGC CTC CGC CTG CCG CTT CTG-3' (FRAG 977) (SEQ. ID NO: 987)

S'-GCT GGG CCC CGG GCG CCC CCT-3' (FRAG 978) (SEQ. ED NO: 988)

5'-CCC CTC TTG CTC GGG TCC CCG TG-3' (FRAG 979) (SEQ. ID NO: 989)

5'-ACAGCGCGTCCTGTGTCTCCAGCAGCATGGCCGGGCCAGCTGGGCCCC-3' (FRAG 980) (SEQ. ID NO: 990)

5'-BCBGCGCGTCCTGTGTCTCCBGCBGCBTGGCCGGGCCBGCTGGGCCCC-3' (FRAG 981) (SEQ. ID NO: 991)

Human Adenosine A3 Receptor Nucleic Acid and Antisense Oligonucleotide Fragments

5'-ACA GAG CAG TGC TGT TGT TGG GCA TCT TGC CTT CCC AGG G BCB GBG CB TGC TGT TGT TGG GCB TCT TGC CTT CCC BGG GCC CTT TTC TGG TGG GGT GGT GCT GTT GTT GGG CTT TCT TCT GTT CCC BCB GBG CBG TGC TGT TGT TGG GCB TCT TGC CTT CCC BGG GCC CTT TTC TGG TGG GGT GGT GCT GTT GTT GGG C TTT CTT CTG TTC CC GAATTCCCAG ATGGGCAGAG GTGGCTGGGC TGGTGACCCT AAGTGTGTCT CCTGCCTTTA TTCTCTCTAG TGGGTTATTC TTTCATGTGG TATCTTGCCT ACAGCATGCT GTGTTTGGAC ACAAACCCCT TTCCTTGGTT TCTCTGACCC AGCTGAGATG GACTGATTCC AAAAGAACTC ACCTATGTAC TGGGGTAGGG GAGGGAGGGT TTTTTGCAGT ATTTAACTAA GGTTCAAAGA GTGCTATATA GTGAGAAAGG CTTCTTTTTT TTTTTTTTTT TTTTTTGGCA GAGTGCTGCC TCCTAGAAAT TTCTCTTGGT AACTTCCTTC TCTGAAGCAC AGATAAAGAA AACAATTACA GTAGAAACAT TTATGAGGGA CACATTGGAG GCCGATGAAG CTTTTCAAGT TCCAGCAGTG CAGGGATGTG GGCAGAACTG ACATTGGAAA ATACTAGAAT GATGGAAATT CAGTTGGAGA GGACTGCCCT TTTTAATGTC TGGGGAGTCT GCTCAGGGAG AAATGACAAG TCTGGCGGGG ACAAGTATGG GATTTGGTAA GACTTGGATC AACTTGGGAT ACAGGGTGGG GGTCGGGAGT GGAATCAATG AATGATGCCA GAGCAGATCA ACTAACAAGA GGACCCTGAT GAGCCCCAGG CAGAGGCGTC TCCCTTATGC CCCACTCTGA AGTGTTTGTT AGTAAACACC AGAACGCCAT TGTTGTTACT GCTGAATTTT ATTTTGGGCT GTACATATTT AGATGCTTAA GGTAAAAATG ATAAAGCCCT CAAGCCACTG TGTGGGTTTG GGTCCAAGTG TTCCTTCTTG CTGCCTCTCT AACACGCCTG GTTAAAATAA TCCCTTTGGA TGGTGCTGAG AAGCACCTGA ACCAAGTGGG TCCCCAAATA ACAATGGCGT GCAAGTGTCT GGTTCCCAGA AGTTGGTGAC TAGGTAAGCA GCTTCAGGGA GAGGGGGCTG ATTCCCAGAC AGTCGCCTGT TCCTGCGGGG ATGGGGCTGA GGCTTGGGGA ATGTGGGCAG GAGGATATGC CATTTGATTC TGTTGCACAC GTTCTTTTCC CTTCTTTCTG TATGTCTGGT CATTCTGCTA TTCTGTCGTT CCTCACATAG GTTGGACATT GGCCGGCTGC CAGCATAAGT GCCAGTGTGA TTTTGCTAGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG TTTTTGCCCT TCTGAGCAGG GAATCTTTGC TTATCCCTTT GACCAAGGAT CTTTGCTGCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGGTTAGGA GGCTGCCACC AAAGTCTCTT TTTTGTTCCT CTGCTTCTCC CGTTTGCCTC CTTATCATGA GATCTTTTTG CTAAGCTGGC AGAAAGATTG CATAGTCAGT GCTTCCAGCT CTGCTCCCAC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC GAGCCTTCTC TATGCCACTC ATGGCTCCTC TTCTGCTCTT TCCATCTTTT TGCTGAGAGT TCTGAGCTCT GTACTTCCTC TTGGCCCATC TCACTTCCTG AAACACCCCT GAAGAGGGTT GCTTATCTTG ATGGAACTCA AAAAGCCAAA AAGCTGCAGG CAGAGGCGTT GAGGACATCT GTTTGGGGAA CTAAGAGCAG CAGCACTTTC AGATTCAGTC CATATAGAGC TGTCCTACAG CATTCTGGAA ACTTGAGGAT GTGCGGTGCA TAAAGGGGCT GGAAGTGACC CACCTGTGAT GAGCCCTTTC TAAGGAGAAG GGTTTCCAAG AGATCACCCC ACCAGAAAAG GGTAGGAATG AGCAAGTTGG GAATTTTAGA CTGTCACTGC ACATGGACCT CTGGGAAGAC GTCTGGCGAG AGCTAGGCCC ACTGGCCCTA CAGACGGATC TTGCTGGCTC ACCTGTCCCT GTGGAGGTTC CCCTGGGAAG GCAAGATGCC CAACAACAGC ACTGCTCTGT CATTGGCCAA TGTTACCTAC ATCACCATGG AAATTTTCAT TGGACTCTGC GCCATAGTGG GCAACGTGCT GGTCATCTGC GTGGTCAAGC TGAACCCCAG CCTGCAGACC ACCACCTTCT ATΓTCATTGT CTCTCTAGCC CTGGCTGACA TTGCTGTTGG GGTGCTGGTC ATGCCTTTGG CCATTGTTGT CAGCCTGGGC ATCACAATCC ACTTCTACAG CTGCCrrTTT ATGACTTGCC TACTGCTTAT CTTTACCCAC GCCTCCATCA TGTCCTTGCT GGCCATCGCT GTGGACCGAT ACTTGCGGGT CAAGCTTACC GTCAGGTAGC CTGCGGCGTG GGGTGGGCAG CAATTGAGGC AGCTGGGAAA TGAGGCTACA AAGCCAGAGC CTGCTGAATT TTATTTTGGA CTGTACATAT TTAGATGCTT AAGGTAAAAA TGATAAAGCC CTCAAGCCAC TGTGTGGGTT GGGTCCAAGT GTTCCTTGCT GCTGCCTCTC TAACACGCCT GGTTAAAATA ATCCCTTTGG ATGGTGCTGA GAAGCACCTG AACCAAGTGG GTCCCCAAAT AACTATGGCG TGCAAGTGTC TGGTTCCCAG AAGTTGGTGA CTAGGTAAGC GACTCAGGGA GAGGGGCTGA TTCCCAGACA GTCGCCTGTT CCTGCTGGGA TGGGGCTGAG GCTTGGGGAA TGTGGGCAGG AGGATATGCC ATTTGATTCT GTTGCACACG TTCTTTTCCC TTCTTTCTGT ATGTCTGGTC ATTCTGCTAT TCTGTCGTTC CTCACATAGG TTGGACATTG GCCGGCTGCC AGCATAAGTG CCAGTGTGAT TTTGCTAGGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG TTTTTGCCCT TCTGAGCAGG GAATCTTTGC TTATCCCTTT GACCAAGGAT CTTTGCTCCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGGTTAGGA GGCTGCCACC AAAGTCTCTT TTTTGTTCCT CTGCTTCTCC CGTTTGCCTC CTTATCATGA GATCTTTTTG CTAAGCTGGC AGAAAGATTG CATAATCAGT GCTTCCAGCT CCGCTCCCAC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC GAGCCTTCTC TATGCCACTC ATGGCTCCTC TTCTGCTCTT TCCATCTTTT TGCTGAGAGT TACTGAGCTC TGTACTTCCT CTTGGCCCAT CTCACTTCCT GAAACACCCC TGAAGAGGGT TGCTTATCTT GATGGAACTC AAAAAGCCAA AAAGCTGCAG GCAGAGGCGT TGAGGACATC TGTTTGGGGA ACTAAGAGCA GCAGCACTTT CAGATTCAGT CCATATAGAG CTGTCCTACA GCATTCTGGA AACTTGAGGA TGTGCGGTGC ATAAAGGGGC TGGAAGTGAC CCACCTGTGA TGAGCCCTTT CTAAGGAGAA GGGTTTCCAA GAGATCACCC CACCAGAAAA GGGTAGGAAT GAGCAAGTTG GGAATTTTAG EPI-109 105

ACTCTCACTG CACATGGACC TCTGGGAAGA CGTCTGGCGA GAGCTAGGCC CACTGGCCCT ACAGACGGAT CTT GCTGGCT CACCTGTCCC TGTGGAGGTT CCCCTGGGAA GGCAAGATGC CCAACAACAG CACTGCTCTG CGAATTCGGG GGACATCTGT TTGGGGAACT AAGAGCAGCA GCACTTTCAG ATTCAGTCCA TATAGAGCTG TCCTACAGCA TTCTGGAAAC TTGAGGATGT GCGGTGCATA AACGGGCTGG AAGTGACCCA CCTGTGATGA GCCCTTTCTA AGGAGAAGGG TTTCCAAGAG ATCACCCCAC CAGAAAAGGG TAGGAATGAG CAAGTTGGGA ATTTTAGACT GTCACTGCAC ATGGACCTCT GGGAAGACGT CTGGCGAGAG CTAGGCCCAC TGGCCCTACA GACGGATCTT GCTGGCTCAC CTGTCCCTGT GGAGGTTCCC CTGGGAAGGC AAGATGCCCA ACAACAGCAC TGCTCTGTCA TTGGCCAATG TTACCTACAT CACCATGGAA ATTTTCATTG GACTCTGCGC CATAGTGGGC AACGTGCTGG TCATCTGCGT GGTCAAGCTG AACCCCAGCC TGCAGACCAC CACCTTCTAT TTCATTGTCT CTCTAGCCCT GGCTGACATT GCTGTTGGGG TGCTGGTCAT GCCTTTGGCC ATTGTTGTCA GCCTGGGCAT CACAATCCAC TTCTACAGCT GCCTTTTTAT GACTTGCCTA CTGCTTATCT TTACCCACGC CTCCATCATG TCCTTGCTGG CCATCGCTGT GGACCGATAC TTGCGGGTCA AGCTTACCGT CAGATACAAG AGGGTCACCA CTCACAGAAG AATATGGCTG GCCCTGGGCC TTTGCTGGCT GGTGTCATTC CTGGTGGGAT TGACCCCCAT GTTTGGCTGG AACATGAAAC TGACCTCAGA GTACCACAGA AATGTCACCT TCCTTTCATG CCAATTTGTT TCCGTCATGA GGATGGACTA CATGGTATAC TTCAGCTTCC TCACCTGGAT TTTCATCCCC CTGGTTGTCA TGTGCGCCAT CTATCTTGAC ATCTTTTACA TCATTCGGAA CAAACTCAGT CTGAACTTAT CTAACTCCAA AGAGACAGGT GCATTTTATG GACGGGAGTT CAAGACGGCT AAGTCCTTGT TTCTGGTTCT TTTCTTGTTT GCTCTGTCAT GGCTGCCTTT ATCTCTCATC AACTGCATCA TCTACTTTAA TGGTGAGGTA CCACAGCTTG TGCTGTACAT GGGCATCCTG CTGTCCCATG CCAACTCCAT GATGAACCCT ATCGTCTATG CCTATAAAAT AAAGAAGTTC AAGGAAACCT ACCTTTTGAT CCTCAAAGCC TGTGTGGTCT GCCATCCCTC TGATTCTTTG GACACAAGCA TTGAGAAGAA TTCTGAGTAG TTATCCATCA GAGATGACTC TGTCTCATTG ACCTTCAGAT TCCCCATCAA CAAACACTTG AGGGCCTGTA TGCCTGGGCC AAGGGATTTT TACATCCTTG ATTACTTCCA CTGAGGTGGG AGCATCTCCA GTGCTCCCCA ATTATATCTC CCCCACTCCA CTACTCTCTT CCTCCACTTC ATTTTTCCTT TGTCCTTTCT CTCTAATTCA GTGTTTTGGA GGCCTGACTT GGGGACAACG TATTATTGAT ATTATTGTCT GTTTTCCTTC TTCCCAATAG AAGAATAAGT CATGGAGCCT GAAGGGTGCC TAGTTGACTT ACTGACAAAA GGCTCTAGTT GGGCTGAACA TGTGTGTGGT GGTGACTCAT TTCCATGCCA TTGTGGAATT GAGCAGAGAA CCTGCTCTCG GAGGATGCCT AGGAGATGTT GGGAACAGAA GAAATAAACT GAGTTTAAGG GGGACTTAAA CTGCTGAATT C GAATTCCCAG ATGGGCAGAG GTGGCTGGGC TGGTGACCCT AAGTGTGTCT CCTGCCTTTA TTCTCTCTAG TGGGTTATTC TTTCATGTGG TATCTTGCCT ACAGCATGCT GTGTTTGGAC ACAAACCCCT TTCCTTGGTT TCTCTGACCC AGCTGAGATG GACTGATTCC AAAAGAACTC ACCTATGTAC TGGGGTAGGG GAGGGAGGGT TTTTTGCAGT ATTTAACTAA GGTTCAAAGA GTGCTATATA GTGAGAAAGG CTTCTTTTTT TTTTTTTTTT TTTTTTGGCA GAGTGCTGCC TCCTAGAAAT TTCTCTTGGT AACTTCCTTC TCTGAAGCAC AGATAAAGAA AACAATTACA GTAGAAACAT TTATGAGGGA CACATTGGAG GCCGATGAAG CTTTTCAAGT TCCAGCAGTG CAGGGATGTG GGCAGAACTG ACATTGGAAA ATACTAGAAT GATGGAAATT CAGTTGGAGA GGACTGCCCT TTTTAATGTC TGGGGAGTCT GCTCAGGGAG AAATGACAAG TCTGGCGGGG ACAAGTATGG GATTTGGTAA GACTTGGATC AACTTGGGAT ACAGGGTGGG GGTCGGGAGT GGAATCAATG AATGATGCCA GAGCAGATCA ACTAACAAGA GGACCCTGAT GAGCCCCAGG CAGAGGCGTC TCCCTTATGC CCCACTCTGA AGTGTTTGTT AGTAAACACC AGAACGCCAT TGTTGTTACT GCTGAATTTT ATTTTGGGCT GTACATATTT AGATGCTTAA GGTAAAAATG ATAAAGCCCT CAAGCCACTG TGTGGGTTTG GGTCCAAGTG TTCCTTCTTG CTGCCTCTCT AACACGCCTG GTTAAAATAA TCCCTTTGGA TGGTGCTGAG AAGCACCTGA ACCAAGTGGG TCCCCAAATA ACAATGGCGT GCAAGTGTCT GGTTCCCAGA AGTTGGTGAC TAGGTAAGCA GCTTCAGGGA GAGGGGGCTG ATTCCCAGAC AGTCGCCTGT TCCTGCGGGG ATGGGGCTGA GGCTTGGGGA ATGTGGGCAG GAGGATATGC CATTTGATTC TGTTGCACAC GTTCTTTTCC CTTCTTTCTG TATGTCTGGT CATTCTGCTA TTCTGTCGTT CCTCACATAG GTTGGACATT GGCCGGCTGC CAGCATAAGT GCCAGTGTGA TTTTGCTAGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG TTTTTGCCCT TCTGAGCAGG GAATCTTTGC TTATCCCTTT GACCAAGGAT CTTTGCTGCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGGTTAGGA GGCTGCCACC AAAGTCTCTT TTTTGTTCCT CTGCTTCTCC CGTTTGCCTC CTTATCATGA GATCTTTTTG CTAAGCTGGC AGAAAGATTG CATAGTCAGT GCTTCCAGCT CTGCTCCCAC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC GAGCCTTCTC TATGCCACTC ATGGCTCCTC TTCTGCTCTT TCCATCTTTT TGCTGAGAGT TCTGAGCTCT GTACTTCCTC TTGGCCCATC TCACTTCCTG AAACACCCCT GAAGAGGGTT GCTTATCTTG ATGGAACTCA AAAAGCCAAA AAGCTGCAGG CAGAGGCGTT GAGGACATCT GTTTGGGGAA CTAAGAGCAG CAGCACTTTC AGATTCAGTC CATATAGAGC TGTCCTACAG CATTCTGGAA ACTTGAGGAT GTGCGGTGCA TAAAGGGGCT GGAAGTGACC CACCTGTGAT GAGCCCTTTC TAAGGAGAAG GGTTTCCAAG AGATCACCCC ACCAGAAAAG GGTAGGAATG AGCAAGTTGG GAATTTTAGA CTGTCACTGC ACATGGACCT CTGGGAAGAC GTCTGGCGAG AGCTAGGCCC ACTGGCCCTA CAGACGGATC TTGCTGGCTC ACCTGTCCCT GTGGAGGTTC CCCTGGGAAG GCAAGATGCC CAACAACAGC ACTGCTCTGT CATTGGCCAA TGTTACCTAC ATCACCATGG AAATTTTCAT TGGACTCTGC GCCATAGTGG GCAACGTGCT GGTCATCTGC GTGGTCAAGC TGAACCCCAG CCTGCAGACC ACCACCTTCT ATTTCATTGT CTCTCTAGCC CTGGCTGACA TTGCTGTTGG GGTGCTGGTC ATGCCTTTGG CCATTGTTGT CAGCCTGGGC ATCACAATCC ACTTCTACAG CTGCCTTTTT ATGACTTGCC TACTGCTTAT CTTTACCCAC GCCTCCATCA TGTCCTTGCT GGCCATCGCT GTGGACCGAT ACTTGCGGGT CAAGCTTACC GTCAGGTAGC CTGCGGCGTG GGGTGGGCAG CAATTGAGGC AGCTGGGAAA TGAGGCTACA AAGCCAGAGC CTGCTGAATT TTATTTTGGA CTGTACATAT TTAGATGCTT AAGGTAAAAA TGATAAAGCC CTCAAGCCAC TGTGTGGGTT GGGTCCAAGT GTTCCTTGCT GCTGCCTCTC TAACACGCCT GGTTAAAATA ATCCCTTTGG ATGGTGCTGA GAAGCACCTG AACCAAGTGG GTCCCCAAAT AACTATGGCG TGCAAGTGTC TGGTTCCCAG AAGTTGGTGA CTAGGTAAGC GACTCAGGGA GAGGGGCTGA TTCCCAGACA GTCGCCTGTT CCTGCTGGGA TGGGGCTGAG GCTTGGGGAA TGTGGGCAGG AGGATATGCC ATTTGATTCT GTTGCACACG TTCTTTTCCC TTCTTTCTGT ATGTCTGGTC ATTCTGCTAT TCTGTCGTTC CTCACATAGG TTGGACATTG GCCGGCTGCC AGCATAAGTG CCAGTGTGAT TTTGCTAGGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG TTTTTGCCCT TCTGAGCAGG GAATCTTTGC TTATCCCTTT GACCAAGGAT CTTTGCTCCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGGTTAGGA GGCTGCCACC AAAGTCTCTT TTTTGTTCCT CTGCTTCTCC CGTTTGCCTC CTTATCATGA GATCTTTTTG CTAAGCTGGC AGAAAGATTG CATAATCAGT GCTTCCAGCT CCGCTCCCAC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC GAGCCTTCTC TATGCCACTC ATGGCTCCTC TTCTGCTCTT TCCATCTTTT TGCTGAGAGT EPI-109 106

TACTGAGCTC TGTACTTCCT CTTGGCCCAT CTCACTTCCT GAAACACCCC TGAAGAGGGT TGCTTATCTT GATGGAACTC AAAAAGCCAA AAAGCTGCAG GCAGAGGCGT TGAGGACATC TGTTTGGGGA ACTAAGAGCA GCAGCACTTT CAGATTCAGT CCATATAGAG CTGTCCTACA GCATTCTGGA AACTTGAGGA TGTGCGGTGC ATAAAGGGGC TGGAAGTGAC CCACCTGTGA TGAGCCCTTT CTAAGGAGAA GGGTTTCCAA GAGATCACCC CACCAGAAAA GGGTAGGAAT GAGCAAGTTG GGAATTTTAG ACTGTCACTG CACATGGACC TCTGGGAAGA CGTCTGGCGA GAGCTAGGCC CACTGGCCCT ACAGACGGAT CTTGCTGGCT CACCTGTCCC TGTGGAGGTT CCCCTGGGAA GGCAAGATGC CCAACAACAG CACTGCTCTG CGAATTCGGG GGACATCTGT TTGGGGAACT AAGAGCAGCA GCACTTTCAG ATTCAGTCCA TATAGAGCTG TCCTACAGCA TTCTGGAAAC TTGAGGATGT GCGGTGCATA AACGGGCTGG AAGTGACCCA CCTGTGATGA GCCCTTTCTA AGGAGAAGGG TTTCCAAGAG ATCACCCCAC CAGAAAAGGG TAGGAATGAG CAAGTTGGGA ATTTTAGACT GTCACTGCAC ATGGACCTCT GGGAAGACGT CTGGCGAGAG CTAGGCCCAC TGGCCCTACA GACGGATCTT GCTGGCTCAC CTGTCCCTGT GGAGGTTCCC CTGGGAAGGC AAGATGCCCA ACAACAGCAC TGCTCTGTCA TTGGCCAATG TTACCTACAT CACCATGGAA ATTTTCATTG GACTCTGCGC CATAGTGGGC AACGTGCTGG TCATCTGCGT GGTCAAGCTG AACCCCAGCC TGCAGACCAC CACCTTCTAT TTCATTGTCT CTCTAGCCCT GGCTGACATT GCTGTTGGGG TGCTGGTCAT GCCTTTGGCC ATTGTTGTCA GCCTGGGCAT CACAATCCAC TTCTACAGCT GCCTTTTTAT GACTTGCCTA CTGCTTATCT TTACCCACGC CTCCATCATG TCCTTGCTGG CCATCGCTGT GGACCGATAC TTGCGGGTCA AGCTTACCGT CAGATACAAG AGGGTCACCA CTCACAGAAG AATATGGCTG GCCCTGGGCC TTTGCTGGCT GGTGTCATTC CTGGTGGGAT TGACCCCCAT GTTTGGCTGG AACATGAAAC TGACCTCAGA GTACCACAGA AATGTCACCT TCCTTTCATG CCAATTTGTT TCCGTCATGA GGATGGACTA CATGGTATAC TTCAGCTTCC TCACCTGGAT TTTCATCCCC CTGGTTGTCA TGTGCGCCAT CTATCTTGAC ATCTTTTACA TCATTCGGAA CAAACTCAGT CTGAACTTAT CTAACTCCAA AGAGACAGGT GCATTTTATG GACGGGAGTT CAAGACGGCT AAGTCCTTGT TTCTGGTTCT TTTCTTGTTT GCTCTGTCAT GGCTGCCTTT ATCTCTCATC AACTGCATCA TCTACTTTAA TGGTGAGGTA CCACAGCTTG TGCTGTACAT GGGCATCCTG CTGTCCCATG CCAACTCCAT GATGAACCCT ATCGTCTATG CCTATAAAAT AAAGAAGTTC AAGGAAACCT ACCTTTTGAT CCTCAAAGCC TGTGTGGTCT GCCATCCCTC TGATTCTTTG GACACAAGCA TTGAGAAGAA TTCTGAGTAG TTATCCATCA GAGATGACTC TGTCTCATTG ACCTTCAGAT TCCCCATCAA CAAACACTTG AGGGCCTGTA TGCCTGGGCC AAGGGATTTT TACATCCTTG ATTACTTCCA CTGAGGTGGG AGCATCTCCA GTGCTCCCCA ATTATATCTC CCCCACTCCA CTACTCTCTT CCTCCACTTC ATTTTTCCTT TGTCCTTTCT CTCTAATTCA GTGTTTTGGA GGCCTGACTT GGGGACAACG TATTATTGAT ATTATTGTCT GTTTTCCTTC TTCCCAATAG AAGAATAAGT CATGGAGCCT GAAGGGTGCC TAGTTGACTT ACTGACAAAA GGCTCTAGTT GGGCTGAACA TGTGTGTGGT GGTGACTCAT TTCCATGCCA TTGTGGAATT GAGCAGAGAA CCTGCTCTCG GAGGATGCCT AGGAGATGTT GGGAACAGAA GAAATAAACT GAGTTTAAGG GGGACTTAAA CTGCTGAATT C -3' (FRAG. NO:1675) (SEQ. ID NO:1688)

5'- CGAATTCGGG GGACATCTGT TTGGGGAACT AAGAGCAGCA GCACTTTCAG ATTCAGTCCA TATAGAGCTG TCCTACAGCA TTCTGGAAAC TTGAGGATGT GCGGTGCATA AACGGGCTGG AAGTGACCCA CCTGTGATGA GCCCTTTCTA AGGAGAAGGG TTTCCAAGAG ATCACCCCAC CAGAAAAGGG TAGGAATGAG CAAGTTGGGA ATTTTAGACT GTCACTGCAC ATGGACCTCT GGGAAGACGT CTGGCGAGAG CTAGGCCCAC TGGCCCTACA GACGGATCTT GCTGGCTCAC CTGTCCCTGT GGAGGTTCCC CTGGGAAGGC AAGATGCCCA ACAACAGCAC TGCTCTGTCA TTGGCCAATG TTACCTACAT CACCATGGAA ATTTTCATTG GACTCTGCGC CATAGTGGGC AACGTGCTGG TCATCTGCGT GGTCAAGCTG AACCCCAGCC TGCAGACCAC CACCTTCTAT TTCATTGTCT CTCTAGCCCT GGCTGACATT GCTGTTGGGG TGCTGGTCAT GCCTTTGGCC ATTGTTGTCA GCCTGGGCAT CACAATCCAC TTCTACAGCT GCCTTTTTAT GACTTGCCTA CTGCTTATCT TTACCCACGC CTCCATCATG TCCTTGCTGG CCATCGCTGT GGACCGATAC TTGCGGGTCA AGCTTACCGT CAGATACAAG AGGGTCACCA CTCACAGAAG AATATGGCTG GCCCTGGGCC TTTGCTGGCT GGTGTCATTC CTGGTGGGAT TGACCCCCAT GTTTGGCTGG AACATGAAAC TGACCTCAGA GTACCACAGA AATGTCACCT TCCTTTCATG CCAATTTGTT TCCGTCATGA GGATGGACTA CATGGTATAC TTCAGCTTCC TCACCTGGAT TTTCATCCCC CTGGTTGTCA TGTGCGCCAT CTATCTTGAC ATCTTTTACA TCATTCGGAA CAAACTCAGT CTGAACTTAT CTAACTCCAA AGAGACAGGT GCATTTTATG GACGGGAGTT CAAGACGGCT AAGTCCTTGT TTCTGGTTCT TTTCTTGTTT GCTCTGTCAT GGCTGCCTTT ATCTCTCATC AACTGCATCA TCTACTTTAA TGGTGAGGTA CCACAGCTTG TGCTGTACAT GGGCATCCTG CTGTCCCATG CCAACTCCAT GATGAACCCT ATCGTCTATG CCTATAAAAT AAAGAAGTTC AAGGAAACCT ACCTTTTGAT CCTCAAAGCC TGTGTGGTCT GCCATCCCTC TGATTCTTTG GACACAAGCA TTGAGAAGAA TTCTGAGTAG TTATCCATCA GAGATGACTC TGTCTCATTG ACCTTCAGAT TCCCCATCAA CAAACACTTG AGGGCCTGTA TGCCTGGGCC AAGGGATTTT TACATCCTTG ATTACTTCCA CTGAGGTGGG AGCATCTCCA GTGCTCCCCA ATTATATCTC CCCCACTCCA CTACTCTCTT CCTCCACTTC ATTTTTCCTT TGTCCTTTCT CTCTAATTCA GTGTTTTGGA GGCCTGACTT GGGGACAACG TATTATTGAT ATTATTGTCT GTTTTCCTTC TTCCCAATAG AAGAATAAGT CATGGAGCCT GAAGGGTGCC TAGTTGACTT ACTGACAAAA GGCTCTAGTT GGGCTGAACA TGTGTGTGGT GGTGACTCAT TTCCATGCCA TTGTGGAATT GAGCAGAGAA CCTGCTCTCG GAGGATGCCT AGGAGATGTT GGGAACAGAA GAAATAAACT GAGTTTAAGG GGGACTTAAA CTGCTGAATT C -3' (FRAG. NO:_) (SEQ. ID NO:2439)

5'- CTGCTGAATT TTATTTTGGA CTGTACATAT TTAGATGCTT AAGGTAAAAA TGATAAAGCC CTCAAGCCAC TGTGTGGGTT GGGTCCAAGT GTTCCTTGCT GCTGCCTCTC TAACACGCCT GGTTAAAATA ATCCCTTTGG ATGGTGCTGA GAAGCACCTG AACCAAGTGG GTCCCCAAAT AACTATGGCG TGCAAGTGTC TGGTTCCCAG AAGTTGGTGA CTAGGTAAGC GACTCAGGGA GAGGGGCTGA TTCCCAGACA GTCGCCTGTT CCTGCTGGGA TGGGGCTGAG GCTTGGGGAA TGTGGGCAGG AGGATATGCC ATTTGATTCT GTTGCACACG TTCTTTTCCC TTCTTTCTGT ATGTCTGGTC ATTCTGCTAT TCTGTCGTTC CTCACATAGG TTGGACATTG GCCGGCTGCC AGCATAAGTG CCAGTGTGAT TTTGCTAGGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG TTTTTGCCCT TCTGAGCAGG GAATCTTTGC TTATCCCTTT GACCAAGGAT CTTTGCTCCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGGTTAGGA GGCTGCCACC AAAGTCTCTT TTTTGTTCCT CTGCTTCTCC CGTTTGCCTC CTTATCATGA GATCTTTTTG CTAAGCTGGC AGAAAGATTG CATAATCAGT GCTTCCAGCT CCGCTCCCAC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC GAGCCTTCTC TATGCCACTC ATGGCTCCTC TTCTGCTCTT TCCATCTTTT TGCTGAGAGT TACTGAGCTC TGTACTTCCT CTTGGCCCAT CTCACTTCCT GAAACACCCC TGAAGAGGGT TGCTTATCTT GATGGAACTC AAAAAGCCAA AAAGCTGCAG GCAGAGGCGT TGAGGACATC TGTTTGGGGA ACTAAGAGCA GCAGCACTTT bPl-109 107

CAGATTCAGT CCATATAGAG CTGTCCTACA GCATTCTGGA AACTTGAGGA TGTGCGGTGC ATAAAGGGGC TGGAAGTGAC CCACCTGTGA TGAGCCCTTT CTAAGGAGAA GGGTTTCCAA GAGATCACCC CACCAGAAAA GGGTAGGAAT GAGCAAGTTG GGAATTTTAG ACTGTCACTG CACATGGACC TCTGGGAAGA CGTCTGGCGA GAGCTAGGCC CACTGGCCCT ACAGACGGAT CTTGCTGGCT CACCTGTCCC TGTGGAGGTT CCCCTGGGAA GGCAAGATGC CCAACAACAG CACTGCTCTG -3' (FRAG. NO: ) (SEQ. ID NO:2438)

5'- GAATTCCCAG ATGGGCAGAG GTGGCTGGGC TGGTGACCCT AAGTGTGTCT CCTGCCTTTA TTCTCTCTAG TGGGTTATTC TTTCATGTGG TATCTTGCCT ACAGCATGCT GTGTTTGGAC ACAAACCCCT TTCCTTGGTT TCTCTGACCC AGCTGAGATG GACTGATTCC AAAAGAACTC ACCTATGTAC TGGGGTAGGG GAGGGAGGGT TTTTTGCAGT ATTTAACTAA GGTTCAAAGA GTGCTATATA GTGAGAAAGG CTTCTTTTTT TT IT-TTTT TTTTTTGGCA GAGTGCTGCC TCCTAGAAAT TTCTCTTGGT AACTTCCTTC TCTGAAGCAC AGATAAAGAA AACAATTACA GTAGAAACAT TTATGAGGGA CACATTGGAG GCCGATGAAG CTTTTCAAGT TCCAGCAGTG CAGGGATGTG GGCAGAACTG ACATTGGAAA ATACTAGAAT GATGGAAATT CAGTTGGAGA GGACTGCCCT TTTTAATGTC TGGGGAGTCT GCTCAGGGAG AAATGACAAG TCTGGCGGGG ACAAGTATGG GATTTGGTAA GACTTGGATC AACTTGGGAT ACAGGGTGGG GGTCGGGAGT GGAATCAATG AATGATGCCA GAGCAGATCA ACTAACAAGA GGACCCTGAT GAGCCCCAGG CAGAGGCGTC TCCCTTATGC CCCACTCTGA AGTGTTTGTT AGTAAACACC AGAACGCCAT TGTTGTTACT GCTGAATTTT ATTTTGGGCT GTACATATTT AGATGCTTAA GGTAAAAATG ATAAAGCCCT CAAGCCACTG TGTGGGTTTG GGTCCAAGTG TTCCTTCTTG CTGCCTCTCT AACACGCCTG GTTAAAATAA TCCCTTTGGA TGGTGCTGAG AAGCACCTGA ACCAAGTGGG TCCCCAAATA ACAATGGCGT GCAAGTGTCT GGTTCCCAGA AGTTGGTGAC TAGGTAAGCA GCTTCAGGGA GAGGGGGCTG ATTCCCAGAC AGTCGCCTGT TCCTGCGGGG ATGGGGCTGA GGCTTGGGGA ATGTGGGCAG GAGGATATGC CATTTGATTC TGTTGCACAC GTTCTTTTCC CTTCTTTCTG TATGTCTGGT CATTCTGCTA TTCTGTCGTT CCTCACATAG GTTGGACATT GGCCGGCTGC CAGCATAAGT GCCAGTGTGA TTTTGCTAGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG TTTTTGCCCT TCTGAGCAGG GAATCTTTGC TTATCCCTTT GACCAAGGAT CTTTGCTGCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGGTTAGGA GGCTGCCACC AAAGTCTCTT TTTTGTTCCT CTGCTTCTCC CGTTTGCCTC CTTATCATGA GATCTTTTTG CTAAGCTGGC AGAAAGATTG CATAGTCAGT GCTTCCAGCT CTGCTCCCAC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC GAGCCTTCTC TATGCCACTC ATGGCTCCTC TTCTGCTCTT TCCATCTTTT TGCTGAGAGT TCTGAGCTCT GTACTTCCTC TTGGCCCATC TCACTTCCTG AAACACCCCT GAAGAGGGTT GCTTATCTTG ATGGAACTCA AAAAGCCAAA AAGCTGCAGG CAGAGGCGTT GAGGACATCT GTTTGGGGAA CTAAGAGCAG CAGCACTTTC AGATTCAGTC CATATAGAGC TGTCCTACAG CATTCTGGAA ACTTGAGGAT GTGCGGTGCA TAAAGGGGCT GGAAGTGACC CACCTGTGAT GAGCCCTTTC TAAGGAGAAG GGTTTCCAAG AGATCACCCC ACCAGAAAAG GGTAGGAATG AGCAAGTTGG GAATTTTAGA CTGTCACTGC ACATGGACCT CTGGGAAGAC GTCTGGCGAG AGCTAGGCCC ACTGGCCCTA CAGACGGATC TTGCTGGCTC ACCTGTCCCT GTGGAGGTTC CCCTGGGAAG GCAAGATGCC CAACAACAGC ACTGCTCTGT CATTGGCCAA TGTTACCTAC ATCACCATGG AAATTTTCAT TGGACTCTGC GCCATAGTGG GCAACGTGCT GGTCATCTGC GTGGTCAAGC TGAACCCCAG CCTGCAGACC ACCACCTTCT ATTTCATTGT CTCTCTAGCC CTGGCTGACA TTGCTGTTGG GGTGCTGGTC ATGCCTTTGG CCATTGTTGT CAGCCTGGGC ATCACAATCC ACTTCTACAG CTGCCTTTTT ATGACTTGCC TACTGCTTAT CTTTACCCAC GCCTCCATCA TGTCCTTGCT GGCCATCGCT GTGGACCGAT ACTTGCGGGT CAAGCTTACC GTCAGGTAGC CTGCGGCGTG GGGTGGGCAG CAATTGAGGC AGCTGGGAAA TGAGGCTACA AAGCCAGAGC -3' (FRAG. NO:_) (SEQ. ID NO:2437)

5'-CGAATTCGGG GGACATCTGT TTGGGGAACT AAGAGCAGCA GCACTTTCAG ATTCAGTCCA TATAGAGCTG TCCTACAGCA TTCTGGAAAC TTGAGGATGT GCGGTGCATA AACGGGCTGG AAGTGACCCA CCTGTGATGA GCCCTTTCTA AGGAGAAGGG TTTCCAAGAG ATCACCCCAC CAGAAAAGGG TAGGAATGAG CAAGTTGGGA ATTTTAGACT GTCACTGCAC ATGGACCTCT GGGAAGACGT CTGGCGAGAG CTAGGCCCAC TGGCCCTACA GACGGATCTT GCTGGCTCAC CTGTCCCTGT GGAGGTTCCC CTGGGAAGGC AAGATGCCCA ACAACAGCAC TGCTCTGTCA TTGGCCAATG TTACCTACAT CACCATGGAA ATTTTCATTG GACTCTGCGC CATAGTGGGC AACGTGCTGG TCATCTGCGT GGTCAAGCTG AACCCCAGCC TGCAGACCAC CACCTTCTAT TTCATTGTCT CTCTAGCCCT GGCTGACATT GCTGTTGGGG TGCTGGTCAT GCCTTTGGCC ATTGTTGTCA GCCTGGGCAT CACAATCCAC TTCTACAGCT GCCTTTTTAT GACTTGCCTA CTGCTTATCT TTACCCACGC CTCCATCATG TCCTTGCTGG CCATCGCTGT GGACCGATAC TTGCGGGTCA AGCTTACCGT CAGATACAAG AGGGTCACCA CTCACAGAAG AATATGGCTG GCCCTGGGCC TTTGCTGGCT GGTGTCATTC CTGGTGGGAT TGACCCCCAT GTTTGGCTGG AACATGAAAC TGACCTCAGA GTACCACAGA AATGTCACCT TCCTTTCATG CCAATTTGTT TCCGTCATGA GGATGGACTA CATGGTATAC TTCAGCTTCC TCACCTGGAT TTTCATCCCC CTGGTTGTCA TGTGCGCCAT CTATCTTGAC ATCTTTTACA TCATTCGGAA CAAACTCAGT CTGAACTTAT CTAACTCCAA AGAGACAGGT GCATTTTATG GACGGGAGTT CAAGACGGCT AAGTCCTTGT TTCTGGTTCT TTTCTTGTTT GCTCTGTCAT GGCTGCCTTT ATCTCTCATC AACTGCATCA TCTACTTTAA TGGTGAGGTA CCACAGCTTG TGCTGTACAT GGGCATCCTG CTGTCCCATG CCAACTCCAT GATGAACCCT ATCGTCTATG CCTATAAAAT AAAGAAGTTC AAGGAAACCT ACCTTTTGAT CCTCAAAGCC TGTGTGGTCT GCCATCCCTC TGATTCTTTG GACACAAGCA TTGAGAAGAA TTCTGAGTAG TTATCCATCA GAGATGACTC TGTCTCATTG ACCTTCAGAT TCCCCATCAA CAAACACTTG AGGGCCTGTA TGCCTGGGCC AAGGGATTTT TACATCCTTG ATTACTTCCA CTGAGGTGGG AGCATCTCCA GTGCTCCCCA ATTATATCTC CCCCACTCCA CTACTCTCTT CCTCCACTTC ATTTTTCCTT TGTCCTTTCT CTCTAATTCA GTGTTTTGGA GGCCTGACTT GGGGACAACG TATTATTGAT ATTATTGTCT GTTTTCCTTC TTCCCAATAG AAGAATAAGT CATGGAGCCT GAAGGGTGCC TAGTTGACTT ACTGACAAAA GGCTCTAGTT GGGCTGAACA TGTGTGTGGT GGTGACTCAT TTCCATGCCA TTGTGGAATT GAGCAGAGAA CCTGCTCTCG GAGGATGCCT AGGAGATGTT GGGAACAGAA GAAATAAACT GAGTTTAAGG GGGACTTAAA CTGCTGAATT C -3' (FRAG. NO: ) (SEQ. ID NO:2427)

5'-CTGCTGAATT TTATTTTGGA CTGTACATAT TTAGATGCTT AAGGTAAAAA TGATAAAGCC CTCAAGCCAC TGTGTGGGTT GGGTCCAAGT GTTCCTTGCT GCTGCCTCTC TAACACGCCT GGTTAAAATA ATCCCTTTGG ATGGTGCTGA GAAGCACCTG AACCAAGTGG GTCCCCAAAT AACTATGGCG TGCAAGTGTC TGGTTCCCAG AAGTTGGTGA CTAGGTAAGC GACTCAGGGA GAGGGGCTGA TTCCCAGACA GTCGCCTGTT CCTGCTGGGA TGGGGCTGAG GCTTGGGGAA TGTGGGCAGG AGGATATGCC ATTTGATTCT GTTGCACACG TTCTTTTCCC TTCTTTCTGT ATGTCTGGTC ATTCTGCTAT TCTGTCGTTC CTCACATAGG TTGGACATTG GCCGGCTGCC AGCATAAGTG CCAGTGTGAT TTTGCTAGGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA EPI-109 108

GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG TTTTTGCCCT TCTGAGCAGG GAATCTTTGC TTATCCCTTT GACCAAGGAT

CTTTGCTCCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT

AAGGTTAGGA GGCTGCCACC AAAGTCTCTT TTTTGTTCCT CTGCTTCTCC CGTTTGCCTC CTTATCATGA GATCTTTTTG

CTAAGCTGGC AGAAAGATTG CATAATCAGT GCTTCCAGCT CCGCTCCCAC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA

TGAATGAACT CTGATACCCA ATCTTGTCTC GAGCCTTCTC TATGCCACTC ATGGCTCCTC TTCTGCTCTT TCCATCTTTT

TGCTGAGAGT TACTGAGCTC TGTACTTCCT CTTGGCCCAT CTCACTTCCT GAAACACCCC TGAAGAGGGT TGCTTATCTT

GATGGAACTC AAAAAGCCAA AAAGCTGCAG GCAGAGGCGT TGAGGACATC TGTTTGGGGA ACTAAGAGCA GCAGCACTTT

CAGATTCAGT CCATATAGAG CTGTCCTACA GCATTCTGGA AACTTGAGGA TGTGCGGTGC ATAAAGGGGC TGGAAGTGAC

CCACCTGTGA TGAGCCCTTT CTAAGGAGAA GGGTTTCCAA GAGATCACCC CACCAGAAAA GGGTAGGAAT GAGCAAGTTG

GGAATTTTAG ACTGTCACTG CACATGGACC TCTGGGAAGA CGTCTGGCGA GAGCTAGGCC CACTGGCCCT ACAGACGGAT

CTTGCTGGCT CACCTGTCCC TGTGGAGGTT CCCCTGGGAA GGCAAGATGC CCAACAACAG CACTGCTCTG-3' (FRAG. NO: )

(SEQ. ID NO:2426)

5'-GAATTCCCAG ATGGGCAGAG GTGGCTGGGC TGGTGACCCT AAGTGTGTCT CCTGCCTTTA TTCTCTCTAG TGGGTTATTC

TTTCATGTGG TATCTTGCCT ACAGCATGCT GTGTTTGGAC ACAAACCCCT TTCCTTGGTT TCTCTGACCC AGCTGAGATG

GACTGATTCC AAAAGAACTC ACCTATGTAC TGGGGTAGGG GAGGGAGGGT TTTTTGCAGT ATTTAACTAA GGTTCAAAGA

GTGCTATATA GTGAGAAAGG CTTCTTTTTT TTTTTTTTTT TTTTTTGGCA GAGTGCTGCC TCCTAGAAAT TTCTCTTGGT

AACTTCCTTC TCTGAAGCAC AGATAAAGAA AACAATTACA GTAGAAACAT TTATGAGGGA CACATTGGAG GCCGATGAAG

CTTTTCAAGT TCCAGCAGTG CAGGGATGTG GGCAGAACTG ACATTGGAAA ATACTAGAAT GATGGAAATT CAGTTGGAGA

GGACTGCCCT TTTTAATGTC TGGGGAGTCT GCTCAGGGAG AAATGACAAG TCTGGCGGGG ACAAGTATGG GATTTGGTAA

GACTTGGATC AACTTGGGAT ACAGGGTGGG GGTCGGGAGT GGAATCAATG AATGATGCCA GAGCAGATCA ACTAACAAGA

GGACCCTGAT GAGCCCCAGG CAGAGGCGTC TCCCTTATGC CCCACTCTGA AGTGTTTGTT AGTAAACACC AGAACGCCAT

TGTTGTTACT GCTGAATTTT ATTTTGGGCT GTACATATTT AGATGCTTAA GGTAAAAATG ATAAAGCCCT CAAGCCACTG

TGTGGGTTTG GGTCCAAGTG TTCCTTCTTG CTGCCTCTCT AACACGCCTG GTTAAAATAA TCCCTTTGGA TGGTGCTGAG

AAGCACCTGA ACCAAGTGGG TCCCCAAATA ACAATGGCGT GCAAGTGTCT GGTTCCCAGA AGTTGGTGAC TAGGTAAGCA

GCTTCAGGGA GAGGGGGCTG ATTCCCAGAC AGTCGCCTGT TCCTGCGGGG ATGGGGCTGA GGCTTGGGGA ATGTGGGCAG

GAGGATATGC CATTTGATTC TGTTGCACAC GTTCTTTTCC CTTCTTTCTG TATGTCTGGT CATTCTGCTA TTCTGTCGTT

CCTCACATAG GTTGGACATT GGCCGGCTGC CAGCATAAGT GCCAGTGTGA TTTTGCTAGG TGTGAGCTGA GAAAGAGAGG

TGGAGGCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG TTTTTGCCCT TCTGAGCAGG GAATCTTTGC TTATCCCTTT

GACCAAGGAT CTTTGCTGCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT

AGTTCTGGCT AAGGTTAGGA GGCTGCCACC AAAGTCTCTT TTTTGTTCCT CTGCTTCTCC CGTTTGCCTC CTTATCATGA

GATCTTTTTG CTAAGCTGGC AGAAAGATTG CATAGTCAGT GCTTCCAGCT CTGCTCCCAC CTGATCCTGC ACTGTCCTCT

GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC GAGCCTTCTC TATGCCACTC ATGGCTCCTC TTCTGCTCTT

TCCATCTTTT TGCTGAGAGT TCTGAGCTCT GTACTTCCTC TTGGCCCATC TCACTTCCTG AAACACCCCT GAAGAGGGTT

GCTTATCTTG ATGGAACTCA AAAAGCCAAA AAGCTGCAGG CAGAGGCGTT GAGGACATCT GTTTGGGGAA CTAAGAGCAG

CAGCACTTTC AGATTCAGTC CATATAGAGC TGTCCTACAG CATTCTGGAA ACTTGAGGAT GTGCGGTGCA TAAAGGGGCT

GGAAGTGACC CACCTGTGAT GAGCCCTTTC TAAGGAGAAG GGTTTCCAAG AGATCACCCC ACCAGAAAAG GGTAGGAATG

AGCAAGTTGG GAATTTTAGA CTGTCACTGC ACATGGACCT CTGGGAAGAC GTCTGGCGAG AGCTAGGCCC ACTGGCCCTA

CAGACGGATC TTGCTGGCTC ACCTGTCCCT GTGGAGGTTC CCCTGGGAAG GCAAGATGCC CAACAACAGC ACTGCTCTGT

CATTGGCCAA TGTTACCTAC ATCACCATGG AAATTTTCAT TGGACTCTGC GCCATAGTGG GCAACGTGCT GGTCATCTGC

GTGGTCAAGC TGAACCCCAG CCTGCAGACC ACCACCTTCT ATTTCATTGT CTCTCTAGCC CTGGCTGACA TTGCTGTTGG

GGTGCTGGTC ATGCCTTTGG CCATTGTTGT CAGCCTGGGC ATCACAATCC ACTTCTACAG CTGCCTTTTT ATGACTTGCC

TACTGCTTAT CTTTACCCAC GCCTCCATCA TGTCCTTGCT GGCCATCGCT GTGGACCGAT ACTTGCGGGT CAAGCTTACC

GTCAGGTAGC CTGCGGCGTG GGGTGGGCAG CAATTGAGGC AGCTGGGAAA TGAGGCTACA AAGCCAGAGC-3' (FRAG.

NO: ) (SEQ. ID NO:2425)

5'-GBG CB TGC-3' (FRAG. NO:1676) (SEQ. ID NO:1689)

5 -TTG TTG GGC-3' (FRAG. NO:1677) (SEQ. ED NO:1690)

5 -TGC CTT CCC BGG G-3' (FRAG. NO:1678) (SEQ. ID NO:1691)

5'-GTT GTT GGG CAT CTT GCC-3' (FRAG. NO:1679) (SEQ ID NO:3)

5 -GTG GGC CTA GCT CTC GCC-3' (GRAG. NO:1680) (SEQ ID NO:5)

5'-ACA GAG CA TGC TGT TGT TGG GCA TCT TGC CTT CCC AGG G-3' (FRAG 982) (SEQ. ID NO: 992)

5'-BCB GBG CB TGC TGT TGT TGG GCB TCT TGC CTT CCC BGG G-3' (FRAG 983) (SEQ. ED NO: 993)

5'-CCC TTT TCT GGT GGG GTG-3' (FRAG 984) (SEQ. ID NO: 994)

5'-GTG CTG TTG TTG GGC-3' (FRAG 985) (SEQ. ID NO: 995) ₅, _{τττ (}- .. Q -_-£ _cc ,, (p_j^_{Q 986) (SE}Q UJ _NO: ^g)

5'-CCC TTT TCT GGT GGG GTG-3' (FRAG 987) (SEQ. ID NO: 997) 5'-GTG CTG TTG TTG GGC- ' (FRAG 988) (SEQ. ID NO: 998) 5'-TTT CTT CTG TTC CC-3' (FRAG 989) (SEQ. ID NO: 999)

Human IgE Receptor β Nucleic Acid and Antisense Oligonucleotide Fragments

5'-TTT CCC CTG GGT CTT CC CTC CTG CTC TTT TTT C ATT TGC TCT CCT ATT ACT TTC TGT GTC CAT TTT TTC ATT

AAC CGA GCT GT BTT TGC TCT CCT BTT BCT TTC TGT GTC CBT TTT TTC BTT BBC CGB GCT GT-3' (FRAG. NO:1681)

(SEQ. ID NO:1692)

5 -CCC CTG GG-3' (FRAG. NO:1682) (SEQ. ID NO:1693)

S -GCTCTCCTBTT-S' (FRAG. NO:1683) (SEQ. ID NO:1694)

5'-CBTTBBCCGBGCTG-3' (FRAG. NO:1684) (SEQ. ID NO:1695)

5'-TTT CCC CTG GGT CTT CC-3' (FRAG 990) (SEQ. ID NO: 1000)

5'-CTC CTG CTC TTT TTT C-3' (FRAG 991) (SEQ. ID NO: 1001) bPl-109 109

ATTTGCTCTCCTATTACTTTCTGTGTCCATTTTTTCATTAACCGAGCTGT (FRAG 992) (SEQ. ID NO: 1002)

BTTTGCTCTCCTBTTBCTTTCTGTGTCCBTTTTTTCBTTBBCCGBGCTGT (FRAG 993) (SEQ. ID NO: 1003)

Human Fc-ε Receptor CD23 Antigen (IgE Receptor) Nucleic Acid and Antisense Oligonucleotide Fragments

5'-GCC TGT GTC TGT CCT CCT GCT TCG TTC CTC TCG TTC CTG CTT GGT GCC CTT GCC G GTC CTG CTC CTC CGG GCT

GTG G GTC GTG GCC CTG GCT CCG GCT GGT GGG CTC CCC TGG CCT TCG CTG GCT GGC GGC GTG C GGG TCT TGC

TCT GGG CCT GGC TGT GGC CGT GGT TGG GGG TCT TC GCT GCC TCC GTT TGG GTG GC TCT CTG AAT ATT GAC CTT

CCT CCA TGG CGG TCC TGC TTG GAT TCT CCC GA TCT CTG BBT BTT GBC CTT CCT CCB TGG CGG TCC TGC TTG GBT

TCT CCC GB-3' (FRAG 1685) (SEQ. ID NO:1696 )

5 -GT CCT CCT-3' (FRAG 1686) (SEQ. ID NO: 1697)

5'-TGT GTC TGT CCT CC-3' (FRAG 1687) (SEQ. ID NO: 1698)

5 -GTG GCC CTG GC-3' (FRAG 1688) (SEQ. ID NO: 1699)

5 -CGT GGT TGG GG-3' (FRAG 1689) (SEQ. ID NO: 1700)

5 -TCT CTG BBT BTT GBC C-3' (FRAG1690) (SEQ. ID NO:1701)

5'-GCC TGT GTC TGT CCT CCT-3' (FRAG 994) (SEQ. ID NO: 1004)

5'-GCT TCG TTC CTC TCG TTC-3' (FRAG 995) (SEQ. ID NO:1005)

5'-CTG CTT GGT GCC CTT GCC G-3' (FRAG 996) (SEQ. ID NO: 1006)

5'-GTC CTG CTC CTC CGG GCT GTG G-3' (FRAG 997) (SEQ. ID NO: 1007)

5'-GTC GTG GCC CTG GCT CCG GCT GGT GGG CTC CCC TGG-3' (FRAG 998) (SEQ. ID NO: 1008)

5'-CCT TCG CTG GCT GGC GGC GTG C-3' (FRAG 999) (SEQ. ID NO: 1009)

5'-GGG TCT TGC TCT GGG CCT GGC TGT-3' (FRAG 1000) (SEQ. ID NO: 1010)

5'-GGC CGT GGT TGG GGG TCT TC-3' (FRAG 1001) (SEQ. ID NO: 1011)

5'-GCT GCC TCC GTT TGG GTG GC (FRAG 1002) (SEQ. ID NO: 1012)

5'-TCT CTG AAT ATT GAC CTT CCT CCA TGG CGG TCC TGC TTG GAT TCT CCC GA (FRAG 1003) (SEQ. ID NO: 1013)

5 -TCT CTG BBT BTT GBC CTT CCT CCB TGG CGG TCC TGC TTG GBT TCT CCC GB (FRAG 1004) (SEQ. ID NO: 1014)

Human IgE Receptor α Subunit Nucleic Acid and Antisense Oligonucleotide Fragments

5 - GCC TTT CCT GGT TCT CTT GTT GTT TTT GGG GTT TGG CTT ACA GTA GAG TAG GGG ATT CCA TGG CAG GAG CCA

TCT TCT TCA TGG ACT CC TTC AAG GAG ACC TTA GGT TTC TGA GGG ACT GCT AAC ACG CCA TCT GGA GC BCB GTB

GBG TBG GGG BTT CCB TGG CBG GBG CCB TCT TCT TCB TGG BCT CC TTC BBG GBG BCC TTB GGT TTC TGB GGG BCT

GCT BBC BCG CCB TCT GGB GC GTT GTT TTT GGG GTT TGG CTT GCC TTT CCT GGT TCT CTT BCB GTB GBG TBG GGG

BTT CCB TGG CBG GBG CCB TCT TCT TCB TGG BCT CC TTC BBG GBG BCC TTB GGT TTC TGB GGG BCT GCT BBC BCG

CCB TCT GGB GC-3'

(FRAG. NO: 1691) (SEQ. ID NO:1702)

5 - TGG BCT CC -3' (FRAG. NO: 1692) (SEQ. ID NO:1703)

5 -CCB TCT GGB-3' (FRAG. NO: 1693) (SEQ. ID NO:1704)

5 -CT GCT BBC BCG-3' (FRAG. NO: 1694) (SEQ. ID NO:1705)

5'-GTT TTT GGG GTT TG-3' (FRAG. NO: 1695) (SEQ. ID NO:1706)

5'-GCC TTT CCT GGT TCT CTT GTT GTT TTT GGG GTT TGG CTT-3' (FRAG. Nθ:1005) (SEQ. ID NO:1015)

5'-ACAGTAGAGTAGGGGATTCCATGGCAGGAGCCATCTTCTTCATGGACTCC-3' (FRAG. NO:1006) (SEQ. ID NO:1016)

5'-TTC AAG GAG ACC TTA GGT TTC TGA GGG ACT GCT AAC ACG CCA TCT GGA GC-3' (FRAG. Nθ:1007) (SEQ. ID

NO:1017)

5'-BCB GTB GBG TBG GGG BTT CCB TGG CBG GBG CCB TCT TCT TCB TGG BCT CC TTC BBG GBG BCC TTB GGT TTC TGB

GGG-3' (FRAG. NO:1008) (SEQ. ID NO:1018)

5 -BCT GCT BBC BCG CCB TCT GGB GC-3' (FRAG. NO:1009) (SEQ. ID NO:1019)

5 -GTT GTT TTT GGG GTT TGG CTT-3' (FRAG. NO:1010) (SEQ. ID NO:1020)

5'-GCC TTT CCT GGT TCT CTT-3' (FRAG. NO:1011) (SEQ. ID NO:1021)

5'-BCBGTBGBGTBGGGGBTTCCBTGGCBGGBGCCBTCTTCTTCBTGGBCTCC-3' (FRAG. NO:1012) (SEQ. ID NO:1022)

5'TTC BBG GBG BCC TTB GGT TTC TGB GGG BCT GCT BBC BCG CCB TCT GGB GC-3' (FRAG. NO:1013) (SEQ. ID

NO > 1023)

Human IgE Receptor (Fc Epsilon R) Nucleic Acid and Antisense Oligonucleotide Fragments

5'-GCC TGT GTC TGT CCT CCT GCT TCG TTC CTC TCG TTC CTG CTT GGT GCC CTT GCC G GTC CTG CTC CTC CGG GCT

GTG G GTC CTC GCC CTG GCT CCG GCT GGT GGG CTC CCC TGG CCT TCG CTG GCT GGC GGC GTG C CCC BGB BCG BGB

CCC GGB CCG BCB GGC CGT GGT TGG GGG TCT TC GCT GCC TCC GTT TGG GTG GC GAT CTC TGA ATA TTGA CCT TCC

ATG GCG GTC CTG CTT GGA GBT CTC TGB BTB TTGB CCT TCC BTG GCG GTC CTG CTT GGB-3' (FRAG: 1696) (SEQ. ID

NO:1707)

5'-TCG TTC CTC TCG-3' (FRAG: 1697) (SEQ. ID NO:1708)

5 -BGB BCG BGB C-3' (FRAG: 1698) (SEQ. ID NO:1709)

5 -TGB BTB TTGB-3' (FRAG: 1699) (SEQ. ID NO:1710)

5'-GCC TGT GTC TGT CCT CCT-3' (FRAG. NO:1014) (SEQ. ID NO:1024)

5'-GCT TCG TTC CTC TCG TTC-3' (FRAG. NO:1015)(SEQ. ID NO:1025)

5'-CTG CTT GGT GCC CTT GCC G-3' (FRAG. NO:1016)(SEQ. ID NO:1026)

5'-GTC CTG CTC CTC CGG GCT GTG G-3' (FRAG. NO:1017)(SEQ. ID NO:1027)

5'-GTC CTC GCC CTG GCT CCG GCT GGT GGG CTC CCC TGG-3' (FRAG. NO:1018) (SEQ. ID NO:1028)

5'-CCT TCG CTG GCT GGC GGC GTG C-3' (FRAG. NO:1019) (SEQ. ID NO:1029)

5'-CCC BGB BCG BGB CCC GGB CCG BCB-3' (FRAG. NO:1020) (SEQ. ID NO:1030)

5'-GGC CGT GGT TGG GGG TCT TC-3' (FRAG. NO:1021) (SEQ. ID NO:1031)

5'-GCT GCC TCC GTT TGG GTG GC-3' (FRAG. NO:1022) (SEQ. ID NO:1032)

5'-GBT CTC TGB BTB TTGB CCT TCC BTG GCG GTC CTG CTT GGB-3' (FRAG. NO:1023) (SEQ. ED NO:1033) EPI-109 1 10

Human High Affinity IgE Receptor Oligonucleotide Fragments

5'-AACAAGAAAA GCGTTGGTAG CTCTGGTGAA TCCCAAAAGA ATGTGGCAGT TGCTAGCCAT GCTCCTGAAT ATGTATAAAC AGTACATCAT ATGACTAAGA GTTTGACTTA GGGGTTAGAT TTTATGTGTT TGAACCCCAA ATTAGTTATT TAATAGTTGG CACCCCAAAA CAAGTTACTT AACCTCACTA AGGTTCAGTT TTCCTGTTTA TAAAATGTAG ATAGTGATAG TATGTACTTT ATAGGATTAT TGTGAAAAAT AAATGAAATA TCAGATTTAT TTAGGATAAC ACCTGGCATA TGTTTGGTAT TCAGAATTAG TTGCTGCTGT TTTATTCTGC TCTCCCTTGC ATCCCACTTT TCTAAGTTGT AAACTAAATA GTTGTACACA GATTGACAGA TTAAGAAAGG CTTGTGATTG TGCTAGACCT ATGCCTATGC CTCTGTCTCA CCAGATTCCA GGTGTATATG TGGAGGTGGG ATAGGGAGTG GAGTAAGTGG GTAAATATTA AATTGCCCAG TTGGGCACCA TCCTGAATAT TATCTCTAAA GAAAGAAGCA AAACCAGGCA CAGCTGATGG GTTAACCAGA TATGATACAG AAAACATTTC CTTCTGCTTT TTGGTTTTAA GCCTATATTT GAAGCCTTAG ATCTCTCCAG CACAGTAAGC ACCAGGAGTC CATGAAGAAG ATG GATCTTCATG

TGGAATGACT GGTTTCATTC AATAGACTTA ATTCAGCAGT CTGTGGGGAA GAGCAAGGTA TGATAGAATG GTTCCTCAAG TGCTTCAGAT GTGAAGTGGG TTTAAATATA CTGTCCCTGT CTTCTTCAGA GTTTTGGTAA AGATAAAATA GGACACTCAT TTAAAAGCAA TCTTTGCAAA TGACAAGCCA CTATAGACAT TAATAGAGTT TTCATTTCCA GTATTATCAT TAATATCAGA TCCTGGAAGA AGGTTGAGCC TTGACCTAGA GCAAAAAAAC AGAAGAATTA GTAAAGGAAT CCTGGAGAAA GCCCCTGCTG TGTATTTAAA GGAGAAAGGG AGATCATGTT GGGAAATTAT AATATTAAAA GTAAACAAAA GCTAGGAAGT AAAATAAAAT AAATTATATG GCCTAGATCC CCATAAGTAA TGGTTTAACT TCTGCCTTCC TGTGTTCTGA GCCAGATTAG GGCACAGTAG AGAAAGAGGA GTCTCTGAAA ATGTTTCCAA TTTCGCTGGT CAGACAGCGG ATCATCAGTG AATCAGATGA AAATTTGTGG ATTTATGCAC TAACTGATCA GCAGGAAATT AAACAAGAAA AGCGTTGGTA GCTCTGGTGA ATCCCAAAAG AATTTGGCAG TTGCTAGCCA TGCTCCTGAA TATGTATAAA CAGTACATCA TATGACTAAG AGTTTGACTT AGGGGTTAGA TTTTATGTGT TTGAACCCCA AATTAGTTAT TTAATAGTTG GCACCCCAAA ACAAGTTACT TAACCTCACT AAGATTCAGT TTTCCTGTTT ATAAAATGTA GATAGTGATA GTATGTACTT TATAGGATTA TTGTGAAAAA TAAATGAAAT ATCAGATTTA TTTAGGATAA CACCTGGCAT ATGTTTGGTA TTCAGTAATT AGTTGCTGCT GTTTTATTCT GCTCTCCCTT GCATCCCACT TTTCTAAGTT GTAAACTAAA TAGTTGTACA CAGATTGACA GATTAAGAAA GGCTTGTGAT TGTGCTAGAC CTATGCCTCT CTCTCACCAG ATTCCAGGTG TATATGTGGA GGTGGGATAG GGAGTGGAGT AAGTGGGTAA ATATTAAATT GCCCAGTTGG GCACCATCCT GAATATTATC TCTAAAGAAA GAAGCAAAAC CAGGCACAGC TGATGGGTTA ACCAGATATG ATACAGAAAA CATTTCCTTC TGCTTTTTGG TTTTAAGCCT ATATTTGAAG CCTTAGATCT CTCCAGCACA GTAAGCACCA GGAGTCCATG AAGAAGATGG CTCCTGCCAT GGAATCCCCT ACTCTACTGT GTGTAGCCTT ACTGTTCTTC GGTAAGTAGA GATTCAATTA CCCCTCCCAG GGAGGCCCAA ATGAATTTGG GGAGCAGCTG GGGTAGGAAC CTTTACTGTG GGTGGTGACT TTTTCTAGGA CATGTGCAAA CTATTGGGCA TTTCCCAGGG ACTCTGTAGT GGAGCCAAGC TAGAAAGCAG AGGCAAGTGG GCTGAGCAAC ACCTAAGGAG GAAGCCAGAC TGAAAGCTTG GTTCCTTGCA TTTGCTCTGG CATCTTCCAG AGTGCAAATT TCCTACCAAG GTAATGAGGG TAGAGGAGAG AAAGAAGCTC TTTCTTCCCC TGATTCTCAT TCCTGAAAAG ACGGTTGGTC CTTAAAATTC CATGGATGTA GATCTTATCC CCACACCCAG ATTCTAGTCC TCTGGAGATA AAGAAGACTG CTGGACACTA ATGTATCCTC TCTGGACTTT TGCAGCTCCA GATGGCGTGT TAGCAGGTGA GTCCTCTGTT CTTGTTCCCT TGGTGTATCA ACATGTCTGG GCATTGCTTT CCTCTCACTA TTTTCTTCGT CCCATCACTT CTGCTTTCTA ATGAGCATGA ATCTGTTCCT TGGCCAGACT ACTTTCCCTC TCCACCTTGC CTTGTCTTTC TTTTTTTCCC TGATTCATTG CATTCTCTCA AGTCATTCTC TCCTCTGTTT TAGTCAATAA CCATGTCTGT TGCACATATA CATGTCTCAT TCTCTCTCCT AGACACTTTG GCATGATCTC GCTCAATAAT TACATTATTA TTATTATTGC CATTTTATAA TTGAGGATGC TGAAACTCAG TGATTTTCTG GTGGTTACAT GGCTAAGGAA CTGGATTTCA ACGTAAGTTC CTTGGATCTA AGTCCAGTTC TCTTCTGACT ATATCACCCT TTTGTTATCA CCATGTATCT ACTTCTTTGG TCTCTGTTCA AATTTGCACT ACATCCCCTT GTTCCAGGAA GCCATTCAAG ACTGACTTTC TTAGTGCCTC TCACTACTTT CTGGAACTGA CATATGTTTT TCACTCTGTA TATACTTACA ATTAAATAGT CATAAATATT CAGAGCTTGG AGAAACCTTA TATTTCATCC AGTCCAGTAA ATTTATCCAT CCATAATTCA CTCATTCATT CACATAATAA ATATTTAATG TAACAATGGT TGAACATGGC AGACAGTGTT TCTACCTCAA AAGAGATTGC AGTCCTCATT TACAGATACT GAATTGAAAT TAACAGAAGT AGAGTGAGTC AGCTCAAATC ACATAGTGAA TTGGTTTCTT TGTTTTTAAA TCTCCTGCAT ATGTGTCCTG TCTTTCTCCC TGTGTTGGGC GTTCCCTGGG GCACCAATAC TAATTTCTCC TTCCCCTAGA AATCAAAACA GGGTCTTATC ACCAACAGAA TAAGGACAGG TTGACCACTG ATTGTCAGAA TATTGCTTCG TTTGTACTTT TAAGCCTAGA CAGTTTTCAA TGACTTTTTT TCTCTCTACA TGTCTTTTCA TATTTTTATC TTCTTGAAGT CCCTCAGAAA CCTAAGGTCT CCTTGAACCC TCCATGGAAT AGAATATTTA AAGGAGAGAA TGTGACTCTT ACATGTAATG GGAACAATTT CTTTGAAGTC AGTTCCACCA AATGGTTCCA CAATGGCAGC CTTTCAGAAG AGACAAATTC AAGTTTGAAT ATTGTGAATG CCAAATTTGA AGACAGTGGA GAATACAAAT GTCAGCACCA ACAAGTTAAT GAGAGTGAAC CTGTGTACCT GGAAGTCTTC AGTGGTAAGT TCCAGGGATA TGGAAATACA GATCTCTCAT GTGAGGGATG GCTCATCTGA AGATGGGAAA AAACAGGTTA TTCCAAGGGT TAGGACACCA GAGTGGGATT CAAGGCCTCT CATTTTTAAG ACCCCTGCAT TGGCTGGGCA CAGTGGCTCA CGCCTGTAAT CCCAGCACTT TGGGAGGCTG AGGCAGGTGG ATCACGAGGT CAGGAGATCG AGACCATCCG GCTAACATGG TGAAACCCCA TCTCTGCTAA AAAATATATA TATATAAAAT TAGCCGGGCG TAGTGGTGGG CACCTGTAGT CCCAGGTACT CGGGAGGCTG AGGCAGGAGA ATGGTGTGAA CCCAGGAGGT GGAGGTTGCA GTGAGCTGAG ATCACGCCAC TGCCCTCCAG CCTGGGCTAC AGAGCAAGAC TCCGTCTCAA AAAATAAATA AATAAATAAA AAAGACCCCT GCATCTCTTT TCTTCTACCC CCTTCCCTTT TGATTACTTG TATGCCTTCT TTCAATATTC TAGTCATCTC TCAATATTAT TCCTCCACCC TATTTTCCTC TATCTTTTCT GCCTAGATTC AGGTATATAT TATGTGGTCA AACAGCATGA CATATATGTG AACATTTCAA AGAGCTGTGT ATCTGGAATA GGATCAAAAG GTTTGACTTA AAGTTTTGCT CTGCATAATC CATATGGCAG GACCTGAATA TTAGGTTGTA CTCTTCGTTA TGAAACATAT CTGGGTACAT TTCCTTATGT CCTCTGTTGT TACTTAAGAA CACATATTTC ATGCTTGTTT CATTTTTATC ACTCCTACTG CCAACAAATA GCATAGCATG CTTAGGCACA TGTGGCTTAA TTAGCAAATG TTGAATAAAC AAATTAATGA TTTTGAATAG TGACCAATAG GTCTCTTTTA TACTCTATAT TTTTCTCTTG AGTGAAAAAA AATGTTTCAA CCTCCATATG TAAATTCCAA ACACAAACTA AAGCAATGTA GAATAGCTTC TTTATTCCCT GGAGTAGGTT CTAGAGAAGT CCTAAAGGAT TGGTCCTAAA TTAATTATGC TTATTATGCT AGCGATATTT CCTTTCAAAA TTCTCCTTTA ATGAATGCTT TTTAATTTTT ACAAAAGCAT TAACCATAGA ATGTGATTCT TGTCTTTCAC TGACTCATTA GTGACAAATA TTTGTTGAGT ACCTACCAAC TCCTAAGTAT TGCTACCAAC TCCTAAATAC TGTGTTGGGC ATTCAGAATA GAATGTAGAA CTAGACAGGG TCCCTGACTT CTTGGAGCAC AGAGCAGTAT GGGAAGAGGA CATTAAATAA AGAATTACAT AAGTAATTAA TTTAAATTAT ACATGTTTTG AAGAAGTTTT TTTTTGACAA CTATAATTAA CACTAGAACT GGGAAGTTTC TATAAGGTAA GAGAGGACAA AATAGACACT CTCCTAAGCT AAAATTCCCA AGAAAGACTG TTTATTTTCC CCTAACTAAC TAGAACTAGC AACAGAAGAT CTGAAAGGAA TTCTGGCTTT CAAGTGTTCC ATGTATGGAC TCATCAGGGA GGTCCGAGAG GCTTTGTGGC CCCAGACTGA CTTTTCAGGA GGGGAAAGGA TTTATCAATA EPI-109 H I

CACAAGACAG GCTCTAAGCA TTATTTTGTG CCCTTTAAAA ATCCACTTTA TGAGCCAAAA AGTGAGTTAA TGATAATTCA TAGTTTCTGA CACATGCTCT ATGCGTGGCT CTCTTTTCTC TATTCATTCT CTCTCTCTTC ATTTATTGTT AAATAAATAA TGTAATGAAT GTTCTTCAGA CTGGCTGCTC CTTCAGGCCT CTGCTGAGGT GGTGATGGAG GGCCAGCCCC TCTTCCTCAG GTGCCATGGT TGGAGGAACT GGGATGTGTA CAAGGTGATC TATTATAAGG ATGGTGAAGC TCTCAAGTAC TGGTATGAGA ACCACAACAT CTCCATTACA AATGCCACAG TTGAAGACAG TGGAACCTAC TACTGTACGG GCAAAGTGTG GCAGCTGGAC TATGAGTCTG AGCCCCTCAA CATTACTGTA ATAAAAGGTG AGTTGGTAAA GGAAAGGAAA AGCATCCATA GCAGGGGAAG GAAGAGAGAA CTTCTGAGCC TGAGCAGTTG CAGCTTGTAG AAGGGGGGCA CCTGTGATAC ACTGGAAAGC CTACCAGACT TGCAATGAGG AGACCTGGGT GATAGTATAT ATCTCAATCT CTGTTTCAAA GCCTTGACTT GTTAAATGGT GATAGTAATA CCTGCTTGCA CTATGAAATT TTTATGAAGA TTAATGTGGT AATATTTGTG AAATGACTTT GTAAACTGTT AAGCACTACC CAAGCATAAC AGATTGTGAT TACTATTTTG ATCTCAAAGT CATCTGTTGC TCCTGGGGGA ACACTTATAT TTATCAAATT GAAAAAAAGT TTCAAAGTTG AATGAAGAAA GGATATAAAG AGCTTGAGGA GCCCATTCCA GCTTAGGAGG GCTGGGAAAG GAAACCAGCA AGTCAGTAAG CTGTGTGCCT GTGTATTGAG GGAGGAGGGA ATGGACTTGA TATGGAGAGG GTAGGGAGGT GGACTGCCTC TATGGCCTGT AAGAAAAACT GCTCTCTCCA AACTCTTTAT AAGAGAGGGA GCCTGTGAAG TATTCACTTT TGAAGGAGAA AGTTAGACTT TTCCTTCACA CACTTTGTAC ATAATAATGT TTAAAAAAGC ATGAGGTCAA AATACATAAT TAAGTCCTAG CAGTTCTCTG TTAACTAATT TGAGACTGAA GTGCTATGTA CTTGTCTCTA GGCTTCCAGT ATCTTCATCT GTAAAACAGA ATATTTGGTC TAGATTCCAT TAGAATCATT TGATAACTTA AAAAATATAT TGATGCTCAT GTCTCATTTC TTGAGATTCT GATTTAATTG GTTTGGGGTG CAGCCTGGGT ATACGTATTT TTCATAGGTC TTTCACATAA TGGTAATGGG TAGCCAATAT TGAGAATCAC TTGTCTAGGT GATCTTTAAA TGATTTCTGG ATGTAATATT CTGAGGCTCT ATAATTTGAG ACTAATCACA AAAATCGGTA CAGTTTATAA ACAGACTAAC AGAACCACAA AATAATAGAA TTGGAAGGCA ATTTAACTAG TGCAATTTCT TCATTTTGCC TAACAGGCAT GTAAGAAATG ATGATTGATT GAGTAATAGG CATTGATGAC CCCTGTCCTC ACTTTGTCCC CTTTCCACCC CTTAATTATA TGTGAATTCT GGTCTTGTCA TTTCGAATAA GGGGTTTATC TTTCCTATTG TCTTCCCCTC TGGGCACGGC ACACTGGCTA CTGGAGTTAA GAGGAAATGC TTAGGACTCC CTGTGGCTCC AGGGAGCACC AACAGAGCAA CTCAACCTAG TGTTAATCTG AGTGTTTTCT CTGTGCTTCT GGATGCCACA TCACGCTAAA AATGAAGGAC AAAGCTTGGT CTTTCTCTTA GGGAGGATGA AACTCTGAAC CTCATTTTTC AGTTCCCAAG ATGAATTATG TTTCTCATTG CATCTGTGTT CCACTACAGC TCCGCGTGAG AAGTACTGGC TACAATTTTT TATCCCATTG TTGGTGGTGA TTCTGTTTGC TGTGGACACA GGATTATTTA TCTCAACTCA GCAGCAGGTC ACATTTCTCT TGAAGATTAA GAGAACCAGG AAAGGCTTCA GACTTCTGAA CCCACATCCT AAGCCAAACC CCAAAAACAA CTGATATAAT TACTCAAGAA ATATTTGCAA CATTAGTTTT TTTCCAGCAT CAGCAATTGC TACTCAATTG TCAAACACAG CTTGCAATAT ACATAGAAAC GTCTGTGCTC AAGGATTTAT AGAAATGCTT CATTAAACTG AGTGAAACTG GTTAAGTGGC ATGTAATAGT AAGTGCTCAA TTAACATTGG TTGAATAAAT GAGAGAATGA ATAGATTCAT TTATTAGCAT TTGTAAAAGA GATGTTCAAT TTCAATAAAA TAAATATAAA ACCATGTAAC AGAATGCTTC TGAGTATTCA AGGCTTGCTA GTTTGTTTGT TTGTTTTCTA CTAAAGGCAA GGACCATGAA GTTCTAGATT GGAAATGTCC TCTCTTGACT ATTGCAAGTG CGATCTAGGA ATGAAAAGAC ATAGGAGGAT GCCAGTGAGG TGGATCATTT TTATGCTTCT TCTTCAGCTT ACTAAATATG AACTTTCAGT TCTTGGCAGA ATCAGGGACA GTCTCAAGAC ATAGGACTCT CAGGATGAAG TAGAGTCCAG GATTCCTCTG TGATTGTTTT GCCCCTCCCA AATTTATATC TTGAACTTAT GTCTTGTATC TTTATACAGC ACCTGAACCA AGCATTTTGG AGAAATTCCA GCTAATAATA ATAACCAAAA CCTTCGGCTC TGAAAACAGT CCAGGACTGA ATAAGATCTT GGGCAAAAGA ACTAGACAGT TTTGGTTTAT TTTCCCTTTC ATTTTATGTC TTCATCATAG TCATTGGAGG CTCATTCTTC TTGTCATGGA GTAAATGGGA TTAAAGTTC TACTAAGAGT CTCCAGCATC CTCCACCTGT CTACCACCGA GCATGGGCCT ATATTTGAAG CCTTAGATCT CTCCAGCACA GTAAGCACCA GGAGTCCATG AAGAAGATGG CTCCTGCCAT GGAATCCCCT ACTCTACTGT GTGTAGCCTT ACTGTTCTTC GCTCCAGATG GCGTGTTAGC AGTCCCTCAG AAACCTAAGG TCTCCTTGAA CCCTCCATGG AATAGAATAT TTAAAGGAGA GAATGTGACT CTTACATGTA ATGGGAACAA TTTCTTTGAA GTCAGTTCCA CCAAATGGTT CCACAATGGC AGCCTTTCAG AAGAGACAAA TTCAAGTTTG AATATTGTGA ATGCCAAATT TGAAGACAGT GGAGAATACA AATGTCAGCA CCAACAAGTT AATGAGAGTG AACCTGTGTA CCTGGAAGTC TTCAGTGACT GGCTGCTCCT TCAGGCCTCT GCTGAGGTGG TGATGGAGGG CCAGCCCCTC TTCCTCAGGT GCCATGGTTG GAGGAACTGG GATGTGTACA AGGTGATCTA TTATAAGGAT GGTGAAGCTC TCAAGTACTG GTATGAGAAC CACAACATCT CCATTACAAA TGCCACAGTT GAAGACAGTG GAACCTACTA CTGTACGGGC AAAGTGTGGC AGCTGGACTA TGAGTCTGAG CCCCTCAACA TTACTGTAAT AAAAGCTCCG CGTGAGAAGT ACTGGCTACA ATTTTTTATC CCATTGTTGG TGGTGATTCT GTTTGCTGTG GACACAGGAT TATTTATCTC AACTCAGCAG CAGGTCACAT TTCTCTTGAA GATTAAGAGA ACCAGGAAAG GCTTCAGACT TCTGAACCCA CATCCTAAGC CAAACCCCAA AAACAACTGA TATAATTACT CAAGAAATAT TTGCAACATT AGTTTTTTTC CAGCATCAGC AATTGCTACT CAATTGTCAA ACACAGCTTG CAATATACAT AGAAACGTCT GTGCTCAAGG ATTTATAGAA ATGCTTCATT AAACTGAGTG AAACTGGTTA AGTGGCATGT AATAGTAAGT GCTCAATTAA CATTGGTTGA ATAAATGAGA GAATGAATAG ATTCATTTAT TAGCATTTGT AAAAGAGATG TTCAATTTCA ATAAAATAAA TATAAAACCA TGTAACAGAA TGCTTCTGAG TAAAAAAAAA AAAAAAAAAA AAAAAAAA TCTCAATATA ATAATATTCT TTATTCCTGG ACAGCTCGGT TAATGAAAAA ATGGACACAG AAAGTAATAG GAGAGCAAAT CTTGCTCTCC CACAGGAGCC TTCCAGTGTG CCTGCATTTG AAGTCTTGGA AATATCTCCC CAGGAAGTAT CTTCAGGCAG ACTATTGAAG TCGGCCTCAT CCCCACCACT GCATACATGG CTGACAGTTT TGAAAAAAGA GCAGGAGTTC CTGGGGGTAA CACAAATTCT GACTGCTATG ATATGCCTTT GTTTTGGAAC AGTTGTCTGC TCTGTACTTG ATATTTCACA CATTGAGGGA GACATTTTTT CATCATTTAA AGCAGGTTAT CCATTCTGGG GAGCCATATT TTTTTCTATT TCTGGAATGT TGTCAATTAT ATCTGAAAGG AGAAATGCAA CATATCTGGT GAGAGGAAGC CTGGGAGCAA ACACTGCCAG CAGCATAGCT GGGGGAACGG GAATTACCAT CCTGATCATC AACCTGAAGA AGAGCTTGGC CTATATCCAC ATCCACAGTT GCCAGAAATT TTTTGAGACC AAGTGCTTTA TGGCTTCCTT TTCCACTGAA ATTGTAGTGA TGATGCTGTT TCTCACCATT CTGGGACTTG GTAGTGCTGT GTCACTCACA ATCTGTGGAG CTGGGGAAGA ACTCAAAGGA AACAAGGTTC CAGAGGATCG TGTTTATGAA GAATTAAACA TATATTCAGC TACTTACAGT GAGTTGGAAG ACCCAGGGGA AATGTCTCCT CCCATTGATT TATAAGAATC ACGTGTCCAG AACACTCTGA TTCACAGCCA AGGATCCAGA AGGCCAAGGT CTTGTTAAGG GGCTACTGGA AAAATTTCTA TTCTCTCCAC AGCCTGCTGG TTTT AAGCTTTTCA

AAGGTGCAAT TGGATAACTT CTGCCATGAG AAATGGCTGA ATTGGGACAC AAGTGGGGAC AATTCCAGAA GAAGGGCACA TCTCTTTCTT TTCTGCAGTT CTTTCTCACC TTCTCAACTC CTACTAAAAT GTCTCATTTT CAGGTTCTGT AAATCCTGCT AGTCTCAGGC AAAATTATGC TCCAGGAGTC TCAAATTTTC TTATTTCATA TTAGTCTTTA TTTAGTAGAC TTCTCAATTT TTCTATTCAT CACAAGTAAA AGCCTGTTGA TCTTAATCAG CCAAGAAACT TATCTGTCTG GCAAATGACT TATGTATAAA GAGAATCATC AATGTCATGA GGTAACCCAT TTCAACTGCC TATTCAGAGC ATGCAGTAAG AGGAAATCCA CCAAGTCTCA ATATAATAAT ATTCTTTATT CCTGGACAGC TCGGTTAATG AAAAAATGGA CACAGAAAGT AATAGGAGAG CAAATCTTGC bPl-109 1 12

TCTCCCACAG GAGCCTTCCA GGTAGGTACA AGGTATTATT TTTTTCTACC CTCAGTCACT TGTGGCAGGG GAAGTCATAG TCACGGTGCT TAGGAGATGA AACTTTATTG ATTTAGGCAT GGATCCATCT AGTTTAATTA ATATATTGGG TATGAGGAAG CTACTTGCTG TACTTTCCAT GTGGTTCTCT CTCCCTGGAG AGGAACATTT TTACTCAGCT TGCAAACTGG AAATAGATTT TCTCACATTA GAAGCTCATT TTCTGGGTAT GAGACAGGAG AGTTCATACT GTGTATGTAG ATCTCTGGCT TCTGGGTCTG ACATGTGCTG AGGGACACAT ATCCTTCACA CATGCTTTTA TAAATACTTG ATAAAGTAAC CTGCTTCTTG ATTGGTCTTT ATAATCCATA AGCTGTGGGA TGCTTCTCTG AAGATGAAAA TAGTAATAGA GTCCCATCTA GCTATTCAAA GCCATTCCTT CATTGTATTC TGTGCACATG AAGTTGGGGT TTGTTACTGA CAAAATATAT TCAGATACAT TTCTATGTTA AAAGGATTGT GAGATGCATA GGTAAATGTG TTTATTTTCA GTTTTACTTG TCAACATAGA TGAATGAGAA AGAACTTGAA AGTAACACTG GATTAAGAAT AGGAAAATTT GGCATGGATT TTGCTCCATT TTGTCCCATC TAATCACTTG GATAGTGTTC AGGTGTTCTT GGTCAGTTAC TTGGATGCTC TGAGCTTTAG TTTCTTGGTG ATTACAATGA AGATTTGAAT TACAGGATGG CTTTGAAAAA ATAAACAAAA CTCCCCTTTC TGTCTGTCGA GAATGTTGCA CAGGGAGTTA CAGAATGTTC TCATGACTGA ATTGCTTTTA AATTTCACAG TGTGCCTGCA TTTGAAGTCT TGGAAATATC TCCCCAGGAA GTATCTTCAG GCAGACTATT GAAGTCGGCC TCATCCCCAC CACTGCATAC ATGGCTGACA GTTTTGAAAA AAGAGCAGGA GTTCCTGGGG GTGAGTGAGC CTCCTCCAAC TTTGACTAGA GTAAGGGTTG GGTCTAGAAA AGAATATTGA GTTGCATCAA CTGTTTTCCC ACTTGGATTC ATGAGAGGTG TTAGGTCCTT TAAAAAACAT GGTAGATAAA GAGTTGACAC TAACTGGGTC CTTTTGGGAA GAGCCAGAAG CATTTCCTCA TAAAGACTTT AAATTGCTAG GACGAGAATG GCCAACAGGA GTGAAGGATT CATAACTTTA TCTTTACTTA GATGTAAAGA ACAATTACTG ATGTTCAACA TGACTACATA CATAAAGGCG CATGGAGAAA AGTATTGGCC TTCCATGCAT TAGGTAGTGC TTGTATCAAT TCTTATAGTG GCTAGGGTAT CCTGGAAAAT CTTACGTGTG GATCATTTCT CAGGACAGTC TAGGACACTA ACGCAGTTTC TCATGTTTGG CTTCTATTAT TAAAAAATGA TACAATCTCG GGAAAATTTT TTTGATTTTC ATGAAATTCA TGTGTTTTTC TATAGGTAAC ACAAATTCTG ACTGCTATGA TATGCCTTTG TTTTGGAACA GTTGTCTGCT CTGTACTTGA TATTTCACAC ATTGAGGGAG ACATTTTTTC ATCATTTAAA GCAGGTTATC CATTCTGGGG AGCCATATTT GTGAGTATAT ATCTATAATT GTTTCTGAAA TAACACTGAA CATAGGTTTT TCTCTTTCTC AGATCTAACC AGTTGTTTAT TCCCAGTATT AAGATGATAT TTATAATTCT TAATTATAAA TATATGTGAG CATATATAAC ATAGATATGC TCATTAACAA CAACAAAAGA TTCTTTTTAC AATTAACGGT GGGTTAAACA TTTAGCCCAC AGTTTTATCC CATGAGAAAC CTGAATCTAA TACAAGTTAA ATGACTTGCC TAAGGGCCAC TTGACTAATA GTAATTGAAC CTAAACTTTC AGAATCCAAC TCCAGGAACA TACTTCTAGC ACTATTCATC AATAAAGTTA TATGATAAAT ACATACAACT TTATCTGTCA ACTAAAAATA ACAACAGAGG CTGGGCATGG TGGCTCACAC CCGTAATCCC AGCACTTTGG GAGGCTGAGG CAGGTGGATC ACCTGAGGTC AGGAGTTTGA GACCAGCCTG ACCAACATGG TGAAACCTCA TCTCTACTAA ATATAAAAAA TTAGCTGAGT GTGATAGTGC ATACCTGTAA TCCAGCTACT TAAGAGGCTG AGGCAGGAGG CTTGTTTGAA CCTGGAAGGC AGAGGTTGCA GTGAGCTGAG ATTGTGCCAT TGCACTCCAG CCTGGGCAAT AAGTGCGAAC TCTGTCTCAA AATAATAATA ATAATAATAG AAAATAAAGT TGTCTTCATG AAAAATGAGG AAAGAGATTG CTGGGGTGAG AAACATTAAG ATCAATGGGC ATATGGTGAC CTTCTATGCC CTAGAAACTC TTTTANGGTA TTTTCTCCTG GTATCTCTTT TACNCATCGT TCTATCTGGA AAAATAGGTG GATGAGTGAG ATAATAACGG TATATACTTT TTAAAGGTCT AATTGACATA TATAAATTGC AAGTATTTCA GATGTCAATT TGCTAACCTT GACACACATA GACACACATG AAAACATCAC CACATTAATA CAATGTATGT ATCCATCATT CCAAAAGCTT CCCTGTGTAT CTTTGTAACT CTTTCTTCCT CCCTCCACTC CTTGTCCTCT CGTTCCCAAG AAAACATTGA TCTGCTTCCT GTGAATATAA ATTAACTTAC ATTTTTTAGA GCTTTATATA AGTATGTTCT CTTTACTGTT TGTCTTCCTT CGCTGCACAG TTATTTTGAG ATTCTTCAAG TTTTTTCTTT ATATCGATAC TTCATTCACA AGAATATATT TTAATTCTAG ACTATGTCAC ATTGACTTTG TCGTCTGCTA AATCCTTAGT GCTCAGATGA CTTGTTCAGG ACTCTCCTTG AACCTGTACC TCTGTTANAT TGAAACTTGT CTCTACTGTC TTTTTATTTC AAACACAGCT TATTAGGTGT CTCTCAACCC ATCAAACNCA CAATCTGAGT CTTTAGGAGA TTGCTTTGAA TTTGTGCTAT TGACTTATAT NTATATNAAA TNTGTAAATG TTTGGTAAAA ATATCATCAT GTACNTTTTC ATAATTACGC TATNTNCACA TGATATATGT CAGACTCTGG AAATATGCAT GCCACAGACA CGTGTTTCTT GCCTAAAGGG GCTGATGGAA GACNCACATA CNAATAGACG ATTGCAGTAG AATGAGAGTG GTGGTCTAAN CAGTACATGT CCTGATGTTG CTCGGACAGT TACTACNCCA AGAGTACCCC CTGCATTGTC AGGGTTAGCA TCTCCTGGAA GCCTCATGTA AATGAAGAAT TTCATGCTCC ATCCAGGACC TAATGAATAA GAATCTGCAT TTTAGCAAGA CCCTCATATG ATTCATATAC ACTTTTTTTT TTTTTTTTTA GATGGAGTCT CACTCTTGTC GCCCAGGCTG GAGTGCAATG GCATGATCTT GGCTCACTGC AACCTCTGCC TCCCGGGTTC AAGTGATTCT CCTGTCTCAG CCTCCCTAGT AGCTGGGACT ACAGGTGCAT GCCACAGTGG CTGGCTAATT TTTGTATTTT TAGTAGAGAC AGGGTTTCAC CATTTTGGTC AGGCTGGTCT TGAACTCATG ACCTCCGGTG ATTCCCCCGC CTCGGCTTCC CAAAGTGCTG GGATTACAGA CATGAGCCAC CACACCCGCC TTATTCGTAT ACNCATTTAA TTCTGAGAAG CACTCTATAG AAAATAAGAA TAAGAAAATA TTGGGCTCAC AGGTGACATT AATAAGTAAC TTTATCGAGT ACCCCAAATT TTACCTATGT TTGGAAGATG GGGTTAAAAG GACACATTGA AAACAAGAAC TCATTGTGGC TTTTTTTTCC TCCTTTTTGA ACAGTTTTCT ATTTCTGGAA TGTTGTCAAT TATATCTGAA AGGAGAAATG CAACATATCT GGTGAGTTGC CCGTTTCTGT CTTTGTCCAT CCTTGAAAAG ATAAGAAGAA CAGAGTTTTA AGAGTCTTAA GGGAAACACA TCTTTGTCTC CTATATTACT TGTGAATGTG GATATATGAT TTTGTTTCAA TCTATTTTGT GTCCTAAGGC TTTTTGCAAC AGAAGTTGGA TATATCATTA GAAACATAAA TTGTACCATT TAACATACAT GAAGTTTATG TTTACCTTGA CGTTCTTCTA AAAAGTGTCC TACACCGGCA TTGTCCTTGT AGGCATATTC ACATGATCAA ATAAAATAAT TAGTTTTCAA TTAAGGAGAA TATTTGAGGA AAGACCGTAC GTGTTCATGT GGTTCCTGAA GGCAGTCCAG TGAGAAAGTA ATATATGCTT CATTAAACAA TGCGGACATT TTCAGGGTTT CCCTTTTTAA CCAAAATTTG GAAGCAATGT GGAATTTACT GGATGCATCC AGCCCTGAAA TGAAGATAGG TTTATTGAAT GTGCCAGCAA GTGCAGGCCC AGGTCTGAGT GTTCTTCATT ATTATCAGGT GAGAGGAAGC CTGGGAGCAA ACACTGCCAG CAGCATAGCT GGGGGAACGG GAATTACCAT CCTGATCATC AACCTGAAGA AGAGCTTGGC CTATATCCAC ATCCACAGTT GCCAGAAATT TTTTGAGACC AAGTGCTTTA TGGCTTCCTT TTCCACTGTA TGTATTTTTT TTTGTGTGGG AAGACTAAGA TTCTGGGTCC TAATGTAAGT AAGAAGCCCT CTTCTCCTGT TCCATGAACA CCATCCTTTT CTGTAACTTC TATTACACAG TATAGTGGTT CTGTAAGTTC ACACAGCCCA GGGAGATGCT GGCTGCCCAC TCCCCTCAAC CCAGGCAAAT TCCTCGGGGT TAAAGTTATC TACTGCAAGT GACGATCTCT GGGTTTTTCT GTGCCTGTGT TTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTATGTGTCA CTTTAAAAGG ACTGGTCAGA TGGTAGGGAG ATGAAAACAG GAGATGCTAT AAGAAAATAA ACTTTTGGGG CGAATACCAA TGTGACTCTT TTTGTTTGTC ATTTGTTGCT GTTCAATAGG AAATTGTAGT GATGATGCTG TTTCTCACCA TTCTGGGACT TGGTAGTGCT GTGTCACTCA CAATCTGTGG AGCTGGGGAA GAACTCAAAG GAAACAAGGT AGATAGAAGC CCGATATAAA ATCTTGAATG ACAGGTTAAC GAATTGGAGC TTTATTCCTT AAAATATGGC CTGGGTTTTC TGAAACATTT CTTCCAGAAA ATAGTTTCTC CAAGTTTTAT TACTTTGGTT TACAAATCTC ACATTTAAAT CACATTTTAT ACCATAAGTA GCACACATTT CATAATATTC CTCTGAATGA GGGTTGGGAT AATAGGACTG ATATGTTAGA AATGCCTTAA AGTGTGTGGA GCATGAGAGA TGGATGTACA hPI-109 1 13

GAAGGCTTGT GAGGAAACCA CCCAGGTATC TGGCCTTGTT TTCTGCCCCA GAACTAGCCG CCTATTCCTG TTTCTGTTTT ATTCCTTTGT TTCTTGACTT TTCCTTTCCA ACTTGCTCTA AAACCTCAGT TTTCTTTCCT TTCTGATTCA TGACTACCAA ATGTTTTCAC TTGCCTCACC CGTCCATTAC ACCTTTGATA AGAACCACCA GACCTTGTGC TCATGTACTT GCCCATGTCT GATGGAAGAA ACATACTCTC TCCATCTGTC CACTTTCCTG AGGCATTCAA GTCTAGCCAC CTTTTAAAAT CACTCTCCTC CAGGCTGGGC ACGGTGTCAC GCCTGTAATC TCAGCACTTT GTGAGGCTGA GGAGGGCGGA TCACTTGAAG TCAGGAGTTC AAAACCAGCC TGGCCAAATG GCAAAACCAA ATCTTCTTCA ATTATAACCA AATCTTAAAC CAAATCTCTA CTAAAAAATA CAACAAAACA AAACAACAAC AACAAAAACA GAAAAGGAAA CATTAGCCCA GCGTGGTGGC AGGTACCTGA GGTTCCAGAT ACTTGGGAGG CTGAAGCAGG AGAATCGCTT GAGCCCAAGA GATGGAGGTT GCAGTGAGCC GAGATCATGC CACTGCACCA CAGCCAGGGT GACAGAGCCA TACTTCCCAG CACATTGGGA GGCCAAAGCT GAAGAATAAT TTGAGGTGAG GATTTGGAGA CCAGCCTGGC CAACATGGTG AAACTCCGTC TGTACTAAAA ATATAAAACT TAGTGGGGCA TGGGGGCACA CACCTGTAAT TTCAGCTACT TAGGAGGCTG AGGCAGGAGA ATTGCTTGAA CCCGGGAGGC GGAAGTTGCA GTGAGCCAAG ATCGTGGCCA CTGCACTCCA GCCTGGGTGA CATAGTGAGA TTCTGTCTCA AAAAAAATAA AAGAAATTTA AAAAATCACT CTCTTCCAAA GATAGATAAA TAAGACAGCA GATATACTAA GGAATAACCT CACCAACTTG TCATTGACTG ACATGATTTC TTTTGGCCCA CTTGGCCAGC TAGTCTGGTT TGGTTTTCTG GAAATGAAAG AAATAATCAG AGTTTAATGA CAGAGAGCGT GAGACCCAGA AAGACAAAAG TAGATGAGGT AAGTCTCTTG AGCGAGACTT CTAGGGATGG GAAATTTGTG GTGATTGATA TGAAATGATT TTTCCCTTAT CAGGTTCCAG AGGATCGTGT TTATGAAGAA TTAAACATAT ATTCAGCTAC TTACAGTGAG TTGGAAGACC CAGGGGAAAT GTCTCCTCCC ATTGATTTAT AAGAATCACG TGTCCAGAAC ACTCTGATTC ACAGCCAAGG ATCCAGAAGG CCAAGGTTTT GTTAAGGGGC TACTGGAAAA ATTTCTATTC TCTCCACAGC CTGCTGGTTT TACATTAGAT TTATTCGCCT GATAAGAATA TTTTGTTTCT GCTGCTTCTG TCCACCTTAA TATGCTCCTT CTATTTGTAG ATATGATAGA CTCCTATTTT TCTTGTTTTA TATTATGACC ACACACATCT CTGCTGGAAA GTCAACATGT AGTAAGCAAG ATTTAACTGT TTGATTATAA CTGTGCAAAT ACAGAAAAAA AGAAGGCTGG CTGAAAGTTG AGTTAAACTT TGACAGTTTG ATAATATTTG GTTCTTAGGG TTTTTTTTTT TTTTAGCATT CTTAATAGTT ACAGTTGGGC ATGATTTGTA CCATCCACCC ATACCCACAC AGTCACAGTC ACACACACAT ATGTATTACT TACACTATAT ATAACTTCCT ATGCAAATAT TTTACCACCA GTCAATAATA CATTTTTGCC AAGACATGAA GTTTTATAAA GATCTGTATA ATTGCCTGAA TCACCAGCAC ATTCACTGAC ATGATATTAT TTGCAGATTG ACAAGTAGGA AGTGGGGAAC TTTTATTAAG TTACTCGTTG TCTGGGGAGG TAAATAGGTT AAAAACAGGG AAATTATAAG TGCAGAGATT AACATTTCAC AAATGTTTAG TGAAACATTT GTGAAAAAAG AAGACTAAAT TAAGACCTGA GCTGAAATAA AGTGACGTGG AAATGGAAAT AATGGTTATA TCTAAAACAT GTAGAAAAAG AGTAACTGGT AGATTTTGTT AACAAATTAA AGAATAAAGT TAGACAAGCA ACTGGTTGAC TAATACATTA AGCGTTTGAG TCTAAGATGA AAGGAGAACA CTGGTTATGT TGATAGAATG ATAAAAAGGG TCGGGCGCGG AGGCTCACGC CTGTAATCCC AGCCCTTTGG GAGGCCGAGG TGGGCAGATC ACGAAGTCAG TAGTTTGAGA CCAGCCTGGC CAACATAGTG AAACCCCGTC TCTACTAAAA ATACAAAAAA AAAATTAGCT GGGTGTGGTG GCAGTCACCT GTAGTCCCAG CTACTTGGGA GGATGAGGCA GGAGAATCGC TTGAACCTGG GAGGCGGAGG TTGCAGTGAG CCGAGATCGC ACCAGTGCAC TCCAGCCTTG GTGACAATGG GAGACTCCAT CTCAAAAAAA AAAAAAAAAA AAAAAAGATA AAAAGTCAGA AATCTGAAAA GTGGAGGAAG AGTACAAATA GACCTAAATT AAGTCTCATT TTTTGGCTTT GATTTTGGGG AGACAAAGGG AAATGCAGCC ATAGAGGGCC TGATGACATC CAATACATGA GTTCTGGTAA AGATAAAATT TGATACACGG TTTGGTGTCA TTATAAGAGA AATCATTATT AAATGAAGCA AGTTAACACT CTAAGAGAAT TATTTTGAGA TAGAAGTGAA GCTAAGCTAA ACTTCACATG CCTATAATTG GAGGGAAAAA CTAAGGATAA AATCTAGCCT AGAAGATACA ATAATTAGTC ATAAACATGC ATTGTGAAAC TG AGAGAGC AGGTAGCCCA AAATAGAGAA AGATTAGATA AAGAGAAAAT AAGTATCCAT CAGAGACAGT ATCTCTAGGC TTGGGCAAGA GAAAAGTCCA CAGTGATAAG CAACTCCACC TAAGGCATGA ATATGCGGCA GAGAAAACAG CAATAGTGAA TGAATGCAAA AGGTGCTGAG CAAATTCCAC ACATGAGTAT TGTGCATGAG TAAATGAATA AAACATTTGC AAAGACCTTT AGAGAAAGAG AATGGGAGCA TATGTGCGAA ATAAGATAGT TGATTATGAA TAGAAGGTAG TGAAGAAAAG CAAGCTAAGA AAAAATTCTG TTTATAAAAG AAGGAAAAGA TAGTTTATGT TTTTAGCCTA AGTATAAGAG TCCTACAGAT GGACTGAAAA AAATCAGTCT GAGAGTATTA GTCACAATTA ATGAAATAAT TACATTTTAT GTATTGAGGA TGCCAAGATT AAAAGGTGAC AGGTAGATGT TAATTTCCCT AGATTGTGAA AGTGATCACG ACAATCACAC AACAAATAAT TAAGTGACTT GGTATGCTTT ATTTAATTGT AGGGCCTGAG GTTTTCCATT CTCATTTTTC TAAAATACAA TTTTGTTTCT CCAAATTTGA CAGCAGAATA AAAACCCTAC CCTTTCACTG TGTATCATGC TAAGCTGCAT CTCTACTCTT GATCATCTGT AGGTATTAAT CACATCACTT CCATGGCATG GATGTTCACA TACAGACTCT TAACCCTGGT TTACCAGGAC CTCTAGGAGT GGATCCAATC TATATCTTTA CAGTTGTATA GTATATGATA TCTCTTTTAT TTCACTCAAT TTATATTTTC ATCATTGACT ACATATTTCT TATACACAAC ACACAATTTA TGAATTTTTT CTCAAGATCA TTCTGAGAGT TGCCCCACCC TACCTGCCTT TTATAGTACG CCCACCTCAG GCAGACACAG AGCACAATGC TGGGGTTCTC TTCACACTAT CACTGCCCCA AATTGTCTTT CTAAATTTCA ACTTCAATGT CATCTTCTCC ATGAAGACCA CTGAATGAAC ACCTTTTCAT CCAGCCTTAA TTTCTTGCTC CATAACTACT CTATCCCACG ATGCAGTATT GTATCATTAA TTATTAGTGT GCTTGTGACC TCCTTATGTA TTCTCAATTA CCTGTATTTG TGCAATAAAT TGGAATAATG TAACTTGATT TCTTATCTGT GTTTGTGTTG GCATGCAAGA TTTAGGTACT TATCAAGATA ATGGGGAATT AAGGCATCAA TAAAATGATG CCAAAGACCA AGAGCAGTTT CTGAAGTCCT CCTTTTCATC AGCTCTTTAT CAAACAGAAC ACTCTATAAA CAACCCATAG CCAGAAAACA GGATGTAGGA ACAATCACCA GCACACTCTA TAAACAACCC ATAGCCAGAA AACAGAATGT AAGGACAATC ACCAGCCATC TTTTGTCAAT AATTGATGGA ATAGAGTTGA AAGGAACTGG AGCATGAGTC ATATTTGACC AGTCAGTCCT CACTCTTATT TACTTGCTAT GTAAACTTGA GAAAGCTTTT TTCTCTTTGT GAACCTCAGG TTTTACATCT GAAAATGAGA AATTTGGAAC AAAAGATTCC TAACTGGTCT TTCTGTTCCC ATATTCTGTG ATTTTTCAAT ATTTAGGATT TTTGGTAATC ACAATTACTT AGTTTGTGGT TGAGATAGCA ACACGAATCA GAACTATTTG GTGGACATAT TTTCAAAGGA GTAGCTCTCC ACTTTGGGTA AAGAAGTGAT GCNGGTCGTG GTGGCTCACG CCTGTAATCC CAGCACTTTA GGGAGGCCAA GGCGGGTGGA TCACGAGGTC AGGAGATCGA GACCATCCTG GCTAACACGG TGAAACCCCG TCTCTACTAA AAAATACAAA AAATTAGCCA GGCGTGGTGG CGGGCGCCTG TAGTCCCACG TACTCGGGAG GCTGAGGCAG GAGAATGGCA TGAACCAGGG AGGCGGAGCT TGCCGTGAGC CGAGATAGCG CCACTGCAGT CCCTCCTGGG CAAAAGAGCA AGACTGCGTC TCAAAAAAAA AAAAAAAAAA AAAAAAAGAA GTGTGTGGAG TAGCAGGACA CCTGCAACAA TAATATTTTT CTAAATCCCT CTGAAAAATG CTAATCAAAG GGTTTTTTTC CTAAAAATTG TCTTAGAAAT AAAATTTCCC CTTTGGGAGA CCGAGGCTGG CAGATCACGA GGTCAGGAGA TAGAGACCAC GGTGAAACCC CGTCTCTACT AAAAATACTA AAAATTAGCC GGGGNGTGGT GGTGGGTACA CCTGTAGTCC CAGCTACTTG GAGGCTGAGG CTGGAGAATC ACGTGAAC-3' (FRAG. NO:_)(SEQ. ID NO:2505) bPI-109 114

5'-AACAAGAAAA GCGTTGGTAG CTCTGGTGAA TCCCAAAAGA ATGTGGCAGT TGCTAGCCAT GCTCCTGAAT ATGTATAAAC AGTACATCAT ATGACTAAGA GTTTGACTTA GGGGTTAGAT TTTATGTGTT TGAACCCCAA ATTAGTTATT TAATAGTTGG CACCCCAAAA CAAGTTACTT AACCTCACTA AGGTTCAGTT TTCCTGTTTA TAAAATGTAG ATAGTGATAG TATGTACTTT ATAGGATTAT TGTGAAAAAT AAATGAAATA TCAGATTTAT TTAGGATAAC ACCTGGCATA TGTTTGGTAT TCAGAATTAG TTGCTGCTGT TTTATTCTGC TCTCCCTTGC ATCCCACTTT TCTAAGTTGT AAACTAAATA GTTGTACACA GATTGACAGA TTAAGAAAGG CTTGTGATTG TGCTAGACCT ATGCCTATGC CTCTGTCTCA CCAGATTCCA GGTGTATATG TGGAGGTGGG ATAGGGAGTG GAGTAAGTGG GTAAATATTA AATTGCCCAG TTGGGCACCA TCCTGAATAT TATCTCTAAA GAAAGAAGCA AAACCAGGCA CAGCTGATGG GTTAACCAGA TATGATACAG AAAACATTTC CTTCTGCTTT TTGGTTTTAA GCCTATATTT GAAGCCTTAG ATCTCTCCAG CACAGTAAGC ACCAGGAGTC CATGAAGAAG ATG-3' (FRAG. NO:_)(SEQ. ID NO:2500) 5'-GATCTTCATG TGGAATGACT GGTTTCATTC AATAGACTTA ATTCAGCAGT CTGTGGGGAA GAGCAAGGTA

TGATAGAATG GTTCCTCAAG TGCTTCAGAT GTGAAGTGGG TTTAAATATA CTGTCCCTGT CTTCTTCAGA GTTTTGGTAA

AGATAAAATA GGACACTCAT TTAAAAGCAA TCTTTGCAAA TGACAAGCCA CTATAGACAT TAATAGAGTT TTCATTTCCA

GTATTATCAT TAATATCAGA TCCTGGAAGA AGGTTGAGCC TTGACCTAGA GCAAAAAAAC AGAAGAATTA GTAAAGGAAT

CCTGGAGAAA GCCCCTGCTG TGTATTTAAA GGAGAAAGGG AGATCATGTT GGGAAATTAT AATATTAAAA GTAAACAAAA

GCTAGGAAGT AAAATAAAAT AAATTATATG GCCTAGATCC CCATAAGTAA TGGTTTAACT TCTGCCTTCC TGTGTTCTGA

GCCAGATTAG GGCACAGTAG AGAAAGAGGA GTCTCTGAAA ATGTTTCCAA TTTCGCTGGT CAGACAGCGG ATCATCAGTG

AATCAGATGA AAATTTGTGG ATTTATGCAC TAACTGATCA GCAGGAAATT AAACAAGAAA AGCGTTGGTA GCTCTGGTGA

ATCCCAAAAG AATTTGGCAG TTGCTAGCCA TGCTCCTGAA TATGTATAAA CAGTACATCA TATGACTAAG AGTTTGACTT

AGGGGTTAGA TTTTATGTGT TTGAACCCCA AATTAGTTAT TTAATAGTTG GCACCCCAAA ACAAGTTACT TAACCTCACT

AAGATTCAGT TTTCCTGTTT ATAAAATGTA GATAGTGATA GTATGTACTT TATAGGATTA TTGTGAAAAA TAAATGAAAT

ATCAGATTTA TTTAGGATAA CACCTGGCAT ATGTTTGGTA TTCAGTAATT AGTTGCTGCT GTTTTATTCT GCTCTCCCTT

GCATCCCACT TTTCTAAGTT GTAAACTAAA TAGTTGTACA CAGATTGACA GATTAAGAAA GGCTTGTGAT TGTGCTAGAC

CTATGCCTCT CTCTCACCAG ATTCCAGGTG TATATGTGGA GGTGGGATAG GGAGTGGAGT AAGTGGGTAA ATATTAAATT

GCCCAGTTGG GCACCATCCT GAATATTATC TCTAAAGAAA GAAGCAAAAC CAGGCACAGC TGATGGGTTA ACCAGATATG

ATACAGAAAA CATTTCCTTC TGCTTTTTGG TTTTAAGCCT ATATTTGAAG CCTTAGATCT CTCCAGCACA GTAAGCACCA

GGAGTCCATG AAGAAGATGG CTCCTGCCAT GGAATCCCCT ACTCTACTGT GTGTAGCCTT ACTGTTCTTC GGTAAGTAGA

GATTCAATTA CCCCTCCCAG GGAGGCCCAA ATGAATTTGG GGAGCAGCTG GGGTAGGAAC CTTTACTGTG GGTGGTGACT

TTTTCTAGGA CATGTGCAAA CTATTGGGCA TTTCCCAGGG ACTCTGTAGT GGAGCCAAGC TAGAAAGCAG AGGCAAGTGG

GCTGAGCAAC ACCTAAGGAG GAAGCCAGAC TGAAAGCTTG GTTCCTTGCA TTTGCTCTGG CATCTTCCAG AGTGCAAATT

TCCTACCAAG GTAATGAGGG TAGAGGAGAG AAAGAAGCTC TTTCTTCCCC TGATTCTCAT TCCTGAAAAG ACGGTTGGTC

CTTAAAATTC CATGGATGTA GATCTTATCC CCACACCCAG ATTCTAGTCC TCTGGAGATA AAGAAGACTG CTGGACACTA

ATGTATCCTC TCTGGACTTT TGCAGCTCCA GATGGCGTGT TAGCAGGTGA GTCCTCTGTT CTTGTTCCCT TGGTGTATCA

ACATGTCTGG GCATTGCTTT CCTCTCACTA TTTTCTTCGT CCCATCACTT CTGCTTTCTA ATGAGCATGA ATCTGTTCCT

TGGCCAGACT ACTTTCCCTC TCCACCTTGC CTTGTCTTTC TTTTTTTCCC TGATTCATTG CATTCTCTCA AGTCATTCTC

TCCTCTGTTT TAGTCAATAA CCATGTCTGT TGCACATATA CATGTCTCAT TCTCTCTCCT AGACACTTTG GCATGATCTC

GCTCAATAAT TACATTATTA TTATTATTGC CATTTTATAA TTGAGGATGC TGAAACTCAG TGATTTTCTG GTGGTTACAT

GGCTAAGGAA CTGGATTTCA ACGTAAGTTC CTTGGATCTA AGTCCAGTTC TCTTCTGACT ATATCACCCT TTTGTTATCA

CCATGTATCT ACTTCTTTGG TCTCTGTTCA AATTTGCACT ACATCCCCTT GTTCCAGGAA GCCATTCAAG ACTGACTTTC

TTAGTGCCTC TCACTACTTT CTGGAACTGA CATATGTTTT TCACTCTGTA TATACTTACA ATTAAATAGT CATAAATATT

CAGAGCTTGG AGAAACCTTA TATTTCATCC AGTCCAGTAA ATTTATCCAT CCATAATTCA CTCATTCATT CACATAATAA

ATATTTAATG TAACAATGGT TGAACATGGC AGACAGTGTT TCTACCTCAA AAGAGATTGC AGTCCTCATT TACAGATACT

GAATTGAAAT TAACAGAAGT AGAGTGAGTC AGCTCAAATC ACATAGTGAA TTGGTTTCTT TGTTTTTAAA TCTCCTGCAT

ATGTGTCCTG TCTTTCTCCC TGTGTTGGGC GTTCCCTGGG GCACCAATAC TAATTTCTCC TTCCCCTAGA AATCAAAACA

GGGTCTTATC ACCAACAGAA TAAGGACAGG TTGACCACTG ATTGTCAGAA TATTGCTTCG TTTGTACTTT TAAGCCTAGA

CAGTTTTCAA TGACTTTTTT TCTCTCTACA TGTCTTTTCA TATTTTTATC TTCTTGAAGT CCCTCAGAAA CCTAAGGTCT

CCTTGAACCC TCCATGGAAT AGAATATTTA AAGGAGAGAA TGTGACTCTT ACATGTAATG GGAACAATTT CTTTGAAGTC

AGTTCCACCA AATGGTTCCA CAATGGCAGC CTTTCAGAAG AGACAAATTC AAGTTTGAAT ATTGTGAATG CCAAATTTGA

AGACAGTGGA GAATACAAAT GTCAGCACCA ACAAGTTAAT GAGAGTGAAC CTGTGTACCT GGAAGTCTTC AGTGGTAAGT

TCCAGGGATA TGGAAATACA GATCTCTCAT GTGAGGGATG GCTCATCTGA AGATGGGAAA AAACAGGTTA TTCCAAGGGT

TAGGACACCA GAGTGGGATT CAAGGCCTCT CATTTTTAAG ACCCCTGCAT TGGCTGGGCA CAGTGGCTCA CGCCTGTAAT

CCCAGCACTT TGGGAGGCTG AGGCAGGTGG ATCACGAGGT CAGGAGATCG AGACCATCCG GCTAACATGG TGAAACCCCA

TCTCTGCTAA AAAATATATA TATATAAAAT TAGCCGGGCG TAGTGGTGGG CACCTGTAGT CCCAGGTACT CGGGAGGCTG

AGGCAGGAGA ATGGTGTGAA CCCAGGAGGT GGAGGTTGCA GTGAGCTGAG ATCACGCCAC TGCCCTCCAG CCTGGGCTAC

AGAGCAAGAC TCCGTCTCAA AAAATAAATA AATAAATAAA AAAGACCCCT GCATCTCTTT TCTTCTACCC CCTTCCCTTT

TGATTACTTG TATGCCTTCT TTCAATATTC TAGTCATCTC TCAATATTAT TCCTCCACCC TATTTTCCTC TATCTTTTCT

GCCTAGATTC AGGTATATAT TATGTGGTCA AACAGCATGA CATATATGTG AACATTTCAA AGAGCTGTGT ATCTGGAATA

GGATCAAAAG GTTTGACTTA AAGTTTTGCT CTGCATAATC CATATGGCAG GACCTGAATA TTAGGTTGTA CTCTTCGTTA

TGAAACATAT CTGGGTACAT TTCCTTATGT CCTCTGTTGT TACTTAAGAA CACATATTTC ATGCTTGTTT CATTTTTATC

ACTCCTACTG CCAACAAATA GCATAGCATG CTTAGGCACA TGTGGCTTAA TTAGCAAATG TTGAATAAAC AAATTAATGA

TTTTGAATAG TGACCAATAG GTCTCTTTTA TACTCTATAT TTTTCTCTTG AGTGAAAAAA AATGTTTCAA CCTCCATATG bPI-109 1 15

TAAATTCCAA ACACAAACTA AAGCAATGTA GAATAGCTTC TTTATTCCCT GGAGTAGGTT CTAGAGAAGT CCTAAAGGAT TGGTCCTAAA TTAATTATGC TTATTATGCT AGCGATATTT CCTTTCAAAA TTCTCCTTTA ATGAATGCTT TTTAATTTTT ACAAAAGCAT TAACCATAGA ATGTGATTCT TGTCTTTCAC TGACTCATTA GTGACAAATA TTTGTTGAGT ACCTACCAAC TCCTAAGTAT TGCTACCAAC TCCTAAATAC TGTGTTGGGC ATTCAGAATA GAATGTAGAA CTAGACAGGG TCCCTGACTT CTTGGAGCAC AGAGCAGTAT GGGAAGAGGA CATTAAATAA AGAATTACAT AAGTAATTAA TTTAAATTAT ACATGTTTTG AAGAAGTTTT TTTTTGACAA CTATAATTAA CACTAGAACT GGGAAGTTTC TATAAGGTAA GAGAGGACAA AATAGACACT CTCCTAAGCT AAAATTCCCA AGAAAGACTG TTTATTTTCC CCTAACTAAC TAGAACTAGC AACAGAAGAT CTGAAAGGAA TTCTGGCTTT CAAGTGTTCC ATGTATGGAC TCATCAGGGA GGTCCGAGAG GCTTTGTGGC CCCAGACTGA CTTTTCAGGA GGGGAAAGGA TTTATCAATA CACAAGACAG GCTCTAAGCA TTATTTTGTG CCCTTTAAAA ATCCACTTTA TGAGCCAAAA AGTGAGTTAA TGATAATTCA TAGTTTCTGA CACATGCTCT ATGCGTGGCT CTCTTTTCTC TATTCATTCT CTCTCTCTTC ATTTATTGTT AAATAAATAA TGTAATGAAT GTTCTTCAGA CTGGCTGCTC CTTCAGGCCT CTGCTGAGGT GGTGATGGAG GGCCAGCCCC TCTTCCTCAG GTGCCATGGT TGGAGGAACT GGGATGTGTA CAAGGTGATC TATTATAAGG ATGGTGAAGC TCTCAAGTAC TGGTATGAGA ACCACAACAT CTCCATTACA AATGCCACAG TTGAAGACAG TGGAACCTAC TACTGTACGG GCAAAGTGTG GCAGCTGGAC TATGAGTCTG AGCCCCTCAA CATTACTGTA ATAAAAGGTG AGTTGGTAAA GGAAAGGAAA AGCATCCATA GCAGGGGAAG GAAGAGAGAA CTTCTGAGCC TGAGCAGTTG CAGCTTGTAG AAGGGGGGCA CCTGTGATAC ACTGGAAAGC CTACCAGACT TGCAATGAGG AGACCTGGGT GATAGTATAT ATCTCAATCT CTGTTTCAAA GCCTTGACTT GTTAAATGGT GATAGTAATA CCTGCTTGCA CTATGAAATT TTTATGAAGA TTAATGTGGT AATATTTGTG AAATGACTTT GTAAACTGTT AAGCACTACC CAAGCATAAC AGATTGTGAT TACTATTTTG ATCTCAAAGT CATCTGTTGC TCCTGGGGGA ACACTTATAT TTATCAAATT GAAAAAAAGT TTCAAAGTTG AATGAAGAAA GGATATAAAG AGCTTGAGGA GCCCATTCCA GCTTAGGAGG GCTGGGAAAG GAAACCAGCA AGTCAGTAAG CTGTGTGCCT GTGTATTGAG GGAGGAGGGA ATGGACTTGA TATGGAGAGG GTAGGGAGGT GGACTGCCTC TATGGCCTGT AAGAAAAACT GCTCTCTCCA AACTCTTTAT AAGAGAGGGA GCCTGTGAAG TATTCACTTT TGAAGGAGAA AGTTAGACTT TTCCTTCACA CACTTTGTAC ATAATAATGT TTAAAAAAGC ATGAGGTCAA AATACATAAT TAAGTCCTAG CAGTTCTCTG TTAACTAATT TGAGACTGAA GTGCTATGTA CTTGTCTCTA GGCTTCCAGT ATCTTCATCT GTAAAACAGA ATATTTGGTC TAGATTCCAT TAGAATCATT TGATAACTTA AAAAATATAT TGATGCTCAT GTCTCATTTC TTGAGATTCT GATTTAATTG GTTTGGGGTG CAGCCTGGGT ATACGTATTT TTCATAGGTC TTTCACATAA TGGTAATGGG TAGCCAATAT TGAGAATCAC TTGTCTAGGT GATCTTTAAA TGATTTCTGG ATGTAATATT CTGAGGCTCT ATAATTTGAG ACTAATCACA AAAATCGGTA CAGTTTATAA ACAGACTAAC AGAACCACAA AATAATAGAA TTGGAAGGCA ATTTAACTAG TGCAATTTCT TCATTTTGCC TAACAGGCAT GTAAGAAATG ATGATTGATT GAGTAATAGG CATTGATGAC CCCTGTCCTC ACTTTGTCCC CTTTCCACCC CTTAATTATA TGTGAATTCT GGTCTTGTCA TTTCGAATAA GGGGTTTATC TTTCCTATTG TCTTCCCCTC TGGGCACGGC ACACTGGCTA CTGGAGTTAA GAGGAAATGC TTAGGACTCC CTGTGGCTCC AGGGAGCACC AACAGAGCAA CTCAACCTAG TGTTAATCTG AGTGTTTTCT CTGTGCTTCT GGATGCCACA TCACGCTAAA AATGAAGGAC AAAGCTTGGT CTTTCTCTTA GGGAGGATGA AACTCTGAAC CTCATTTTTC AGTTCCCAAG ATGAATTATG TTTCTCATTG CATCTGTGTT CCACTACAGC TCCGCGTGAG AAGTACTGGC TACAATTTTT TATCCCATTG TTGGTGGTGA TTCTGTTTGC TGTGGACACA GGATTATTTA TCTCAACTCA GCAGCAGGTC ACATTTCTCT TGAAGATTAA GAGAACCAGG AAAGGCTTCA GACTTCTGAA CCCACATCCT AAGCCAAACC CCAAAAACAA CTGATATAAT TACTCAAGAA ATATTTGCAA CATTAGTTTT TTTCCAGCAT CAGCAATTGC TACTCAATTG TCAAACACAG CTTGCAATAT ACATAGAAAC GTCTGTGCTC AAGGATTTAT AGAAATGCTT CATTAAACTG AGTGAAACTG GTTAAGTGGC ATGTAATAGT AAGTGCTCAA TTAACATTGG TTGAATAAAT GAGAGAATGA ATAGATTCAT TTATTAGCAT TTGTAAAAGA GATGTTCAAT TTCAATAAAA TAAATATAAA ACCATGTAAC AGAATGCTTC TGAGTATTCA AGGCTTGCTA GTTTGTTTGT TTGTTTTCTA CTAAAGGCAA GGACCATGAA GTTCTAGATT GGAAATGTCC TCTCTTGACT ATTGCAAGTG CGATCTAGGA ATGAAAAGAC ATAGGAGGAT GCCAGTGAGG TGGATCATTT TTATGCTTCT TCTTCAGCTT ACTAAATATG AACTTTCAGT TCTTGGCAGA ATCAGGGACA GTCTCAAGAC ATAGGACTCT CAGGATGAAG TAGAGTCCAG GATTCCTCTG TGATTGTTTT GCCCCTCCCA AATTTATATC TTGAACTTAT GTCTTGTATC TTTATACAGC ACCTGAACCA AGCATTTTGG AGAAATTCCA GCTAATAATA ATAACCAAAA CCTTCGGCTC TGAAAACAGT CCAGGACTGA ATAAGATCTT GGGCAAAAGA ACTAGACAGT TTTGGTTTAT TTTCCCTTTC ATTTTATGTC TTCATCATAG TCATTGGAGG CTCATTCTTC TTGTCATGGA GTAAATGGGA TTAAAGTTC-3' (FRAG. NO: (SEQ. ID NO:2501)

5'-TACTAAGAGT CTCCAGCATC CTCCACCTGT CTACCACCGA GCATGGGCCT ATATTTGAAG CCTTAGATCT CTCCAGCACA GTAAGCACCA GGAGTCCATG AAGAAGATGG CTCCTGCCAT GGAATCCCCT ACTCTACTGT GTGTAGCCTT ACTGTTCTTC GCTCCAGATG GCGTGTTAGC AGTCCCTCAG AAACCTAAGG TCTCCTTGAA CCCTCCATGG AATAGAATAT TTAAAGGAGA GAATGTGACT CTTACATGTA ATGGGAACAA TTTCTTTGAA GTCAGTTCCA CCAAATGGTT CCACAATGGC AGCCTTTCAG AAGAGACAAA TTCAAGTTTG AATATTGTGA ATGCCAAATT TGAAGACAGT GGAGAATACA AATGTCAGCA CCAACAAGTT AATGAGAGTG AACCTGTGTA CCTGGAAGTC TTCAGTGACT GGCTGCTCCT TCAGGCCTCT GCTGAGGTGG TGATGGAGGG CCAGCCCCTC TTCCTCAGGT GCCATGGTTG GAGGAACTGG GATGTGTACA AGGTGATCTA TTATAAGGAT GGTGAAGCTC TCAAGTACTG GTATGAGAAC CACAACATCT CCATTACAAA TGCCACAGTT GAAGACAGTG GAACCTACTA CTGTACGGGC AAAGTGTGGC AGCTGGACTA TGAGTCTGAG CCCCTCAACA TTACTGTAAT AAAAGCTCCG CGTGAGAAGT ACTGGCTACA ATTTTTTATC CCATTGTTGG TGGTGATTCT GTTTGCTGTG GACACAGGAT TATTTATCTC AACTCAGCAG CAGGTCACAT TTCTCTTGAA GATTAAGAGA ACCAGGAAAG GCTTCAGACT TCTGAACCCA CATCCTAAGC CAAACCCCAA AAACAACTGA TATAATTACT CAAGAAATAT TTGCAACATT AGTTTTTTTC CAGCATCAGC AATTGCTACT CAATTGTCAA ACACAGCTTG CAATATACAT AGAAACGTCT GTGCTCAAGG ATTTATAGAA ATGCTTCATT AAACTGAGTG AAACTGGTTA AGTGGCATGT AATAGTAAGT GCTCAATTAA CATTGGTTGA ATAAATGAGA GAATGAATAG ATTCATTTAT TAGCATTTGT AAAAGAGATG TTCAATTTCA ATAAAATAAA TATAAAACCA TGTAACAGAA TGCTTCTGAG TAAAAAAAAA AAAAAAAAAA AAAAAAAA- EPI-109 1 16

3 ' ( FRAG . NO : _) ( SEQ . ID NO : 2502 )

5'-TCTCAATATA ATAATATTCT TTATTCCTGG ACAGCTCGGT TAATGAAAAA ATGGACACAG AAAGTAATAG GAGAGCAAAT CTTGCTCTCC CACAGGAGCC TTCCAGTGTG CCTGCATTTG AAGTCTTGGA AATATCTCCC CAGGAAGTAT CTTCAGGCAG ACTATTGAAG TCGGCCTCAT CCCCACCACT GCATACATGG CTGACAGTTT TGAAAAAAGA GCAGGAGTTC CTGGGGGTAA CACAAATTCT GACTGCTATG ATATGCCTTT GTTTTGGAAC AGTTGTCTGC TCTGTACTTG ATATTTCACA CATTGAGGGA GACATTTTTT CATCATTTAA AGCAGGTTAT CCATTCTGGG GAGCCATATT TTTTTCTATT TCTGGAATGT TGTCAATTAT ATCTGAAAGG AGAAATGCAA CATATCTGGT GAGAGGAAGC CTGGGAGCAA ACACTGCCAG CAGCATAGCT GGGGGAACGG GAATTACCAT CCTGATCATC AACCTGAAGA AGAGCTTGGC CTATATCCAC ATCCACAGTT GCCAGAAATT TTTTGAGACC AAGTGCTTTA TGGCTTCCTT TTCCACTGAA ATTGTAGTGA TGATGCTGTT TCTCACCATT CTGGGACTTG GTAGTGCTGT GTCACTCACA ATCTGTGGAG CTGGGGAAGA ACTCAAAGGA AACAAGGTTC CAGAGGATCG TGTTTATGAA GAATTAAACA TATATTCAGC TACTTACAGT GAGTTGGAAG ACCCAGGGGA AATGTCTCCT CCCATTGATT TATAAGAATC ACGTGTCCAG AACACTCTGA TTCACAGCCA AGGATCCAGA AGGCCAAGGT CTTGTTAAGG GGCTACTGGA AAAATTTCTA TTCTCTCCAC AGCCTGCTGG TTTT-3' (FRAG. NO _)(SEQ ID NO. 2503)

5'-AAGCTTTTCA AAGGTGCAAT TGGATAACTT CTGCCATGAG AAATGGCTGA ATTGGGACAC AAGTGGGGAC AATTCCAGAA GAAGGGCACA TCTCTTTCTT TTCTGCAGTT CTTTCTCACC TTCTCAACTC CTACTAAAAT GTCTCATTTT CAGGTTCTGT AAATCCTGCT AGTCTCAGGC AAAATTATGC TCCAGGAGTC TCAAATTTTC TTATTTCATA TTAGTCTTTA TTTAGTAGAC TTCTCAATTT TTCTATTCAT CACAAGTAAA AGCCTGTTGA TCTTAATCAG CCAAGAAACT TATCTGTCTG GCAAATGACT TATGTATAAA GAGAATCATC AATGTCATGA GGTAACCCAT TTCAACTGCC TATTCAGAGC ATGCAGTAAG AGGAAATCCA CCAAGTCTCA ATATAATAAT ATTCTTTATT CCTGGACAGC TCGGTTAATG AAAAAATGGA CACAGAAAGT AATAGGAGAG CAAATCTTGC TCTCCCACAG GAGCCTTCCA GGTAGGTACA AGGTATTATT TTTTTCTACC CTCAGTCACT TGTGGCAGGG GAAGTCATAG TCACGGTGCT TAGGAGATGA AACTTTATTG ATTTAGGCAT GGATCCATCT AGTTTAATTA ATATATTGGG TATGAGGAAG CTACTTGCTG TACTTTCCAT GTGGTTCTCT CTCCCTGGAG AGGAACATTT TTACTCAGCT TGCAAACTGG AAATAGATTT TCTCACATTA GAAGCTCATT TTCTGGGTAT GAGACAGGAG AGTTCATACT GTGTATGTAG ATCTCTGGCT TCTGGGTCTG ACATGTGCTG AGGGACACAT ATCCTTCACA CATGCTTTTA TAAATACTTG ATAAAGTAAC CTGCTTCTTG ATTGGTCTTT ATAATCCATA AGCTGTGGGA TGCTTCTCTG AAGATGAAAA TAGTAATAGA GTCCCATCTA GCTATTCAAA GCCATTCCTT CATTGTATTC TGTGCACATG AAGTTGGGGT TTGTTACTGA CAAAATATAT TCAGATACAT TTCTATGTTA AAAGGATTGT GAGATGCATA GGTAAATGTG TTTATTTTCA GTTTTACTTG TCAACATAGA TGAATGAGAA AGAACTTGAA AGTAACACTG GATTAAGAAT AGGAAAATTT GGCATGGATT TTGCTCCATT TTGTCCCATC TAATCACTTG GATAGTGTTC AGGTGTTCTT GGTCAGTTAC TTGGATGCTC TGAGCTTTAG TTTCTTGGTG ATTACAATGA AGATTTGAAT TACAGGATGG CTTTGAAAAA ATAAACAAAA CTCCCCTTTC TGTCTGTCGA GAATGTTGCA CAGGGAGTTA CAGAATGTTC TCATGACTGA ATTGCTTTTA AATTTCACAG TGTGCCTGCA TTTGAAGTCT TGGAAATATC TCCCCAGGAA GTATCTTCAG GCAGACTATT GAAGTCGGCC TCATCCCCAC CACTGCATAC ATGGCTGACA GTTTTGAAAA AAGAGCAGGA GTTCCTGGGG GTGAGTGAGC CTCCTCCAAC TTTGACTAGA GTAAGGGTTG GGTCTAGAAA AGAATATTGA GTTGCATCAA CTGTTTTCCC ACTTGGATTC ATGAGAGGTG TTAGGTCCTT TAAAAAACAT GGTAGATAAA GAGTTGACAC TAACTGGGTC CTTTTGGGAA GAGCCAGAAG CATTTCCTCA TAAAGACTTT AAATTGCTAG GACGAGAATG GCCAACAGGA GTGAAGGATT CATAACTTTA TCTTTACTTA GATGTAAAGA ACAATTACTG ATGTTCAACA TGACTACATA CATAAAGGCG CATGGAGAAA AGTATTGGCC TTCCATGCAT TAGGTAGTGC TTGTATCAAT TCTTATAGTG GCTAGGGTAT CCTGGAAAAT CTTACGTGTG GATCATTTCT CAGGACAGTC TAGGACACTA ACGCAGTTTC TCATGTTTGG CTTCTATTAT TAAAAAATGA TACAATCTCG GGAAAATTTT TTTGATTTTC ATGAAATTCA TGTGTTTTTC TATAGGTAAC ACAAATTCTG ACTGCTATGA TATGCCTTTG TTTTGGAACA GTTGTCTGCT CTGTACTTGA TATTTCACAC ATTGAGGGAG ACATTTTTTC ATCATTTAAA GCAGGTTATC CATTCTGGGG AGCCATATTT GTGAGTATAT ATCTATAATT GTTTCTGAAA TAACACTGAA CATAGGTTTT TCTCTTTCTC AGATCTAACC AGTTGTTTAT TCCCAGTATT AAGATGATAT TTATAATTCT TAATTATAAA TATATGTGAG CATATATAAC ATAGATATGC TCATTAACAA CAACAAAAGA TTCTTTTTAC AATTAACGGT GGGTTAAACA TTTAGCCCAC AGTTTTATCC CATGAGAAAC CTGAATCTAA TACAAGTTAA ATGACTTGCC TAAGGGCCAC TTGACTAATA GTAATTGAAC CTAAACTTTC AGAATCCAAC TCCAGGAACA TACTTCTAGC ACTATTCATC AATAAAGTTA TATGATAAAT ACATACAACT TTATCTGTCA ACTAAAAATA ACAACAGAGG CTGGGCATGG TGGCTCACAC CCGTAATCCC AGCACTTTGG GAGGCTGAGG CAGGTGGATC ACCTGAGGTC AGGAGTTTGA GACCAGCCTG ACCAACATGG TGAAACCTCA TCTCTACTAA ATATAAAAAA TTAGCTGAGT GTGATAGTGC ATACCTGTAA TCCAGCTACT TAAGAGGCTG AGGCAGGAGG CTTGTTTGAA CCTGGAAGGC AGAGGTTGCA GTGAGCTGAG ATTGTGCCAT TGCACTCCAG CCTGGGCAAT AAGTGCGAAC TCTGTCTCAA AATAATAATA ATAATAATAG AAAATAAAGT TGTCTTCATG AAAAATGAGG AAAGAGATTG CTGGGGTGAG AAACATTAAG ATCAATGGGC ATATGGTGAC CTTCTATGCC CTAGAAACTC TTTTANGGTA TTTTCTCCTG GTATCTCTTT TACNCATCGT TCTATCTGGA AAAATAGGTG GATGAGTGAG ATAATAACGG TATATACTTT TTAAAGGTCT AATTGACATA TATAAATTGC AAGTATTTCA GATGTCAATT TGCTAACCTT GACACACATA GACACACATG AAAACATCAC CACATTAATA CAATGTATGT ATCCATCATT CCAAAAGCTT CCCTGTGTAT CTTTGTAACT CTTTCTTCCT CCCTCCACTC CTTGTCCTCT CGTTCCCAAG AAAACATTGA TCTGCTTCCT GTGAATATAA ATTAACTTAC ATTTTTTAGA GCTTTATATA AGTATGTTCT CTTTACTGTT TGTCTTCCTT CGCTGCACAG TTATTTTGAG ATTCTTCAAG TTTTTTCTTT ATATCGATAC TTCATTCACA AGAATATATT TTAATTCTAG ACTATGTCAC ATTGACTTTG TCGTCTGCTA AATCCTTAGT GCTCAGATGA CTTGTTCAGG ACTCTCCTTG AACCTGTACC TCTGTTANAT TGAAACTTGT CTCTACTGTC TTTTTATTTC AAACACAGCT TATTAGGTGT CTCTCAACCC ATCAAACNCA CAATCTGAGT CTTTAGGAGA TTGCTTTGAA TTTGTGCTAT TGACTTATAT NTATATNAAA TNTGTAAATG TTTGGTAAAA ATATCATCAT GTACNTTTTC ATAATTACGC TATNTNCACA TGATATATGT CAGACTCTGG AAATATGCAT GCCACAGACA CGTGTTTCTT GCCTAAAGGG GCTGATGGAA GACNCACATA CNAATAGACG ATTGCAGTAG AATGAGAGTG GTGGTCTAAN CAGTACATGT CCTGATGTTG CTCGGACAGT TACTACNCCA AGAGTACCCC CTGCATTGTC AGGGTTAGCA TCTCCTGGAA GCCTCATGTA AATGAAGAAT TTCATGCTCC ATCCAGGACC TAATGAATAA GAATCTGCAT TTTAGCAAGA CCCTCATATG ATTCATATAC ACTTTTTTTT TTTTTTTTTA GATGGAGTCT CACTCTTGTC GCCCAGGCTG GAGTGCAATG GCATGATCTT GGCTCACTGC AACCTCTGCC TCCCGGGTTC AAGTGATTCT CCTGTCTCAG CCTCCCTAGT AGCTGGGACT ACAGGTGCAT GCCACAGTGG CTGGCTAATT TTTGTATTTT TAGTAGAGAC AGGGTTTCAC CATTTTGGTC AGGCTGGTCT TGAACTCATG ACCTCCGGTG ATTCCCCCGC CTCGGCTTCC CAAAGTGCTG GGATTACAGA CATGAGCCAC CACACCCGCC TTATTCGTAT ACNCATTTAA TTCTGAGAAG CACTCTATAG AAAATAAGAA TAAGAAAATA TTGGGCTCAC AGGTGACATT AATAAGTAAC TTTATCGAGT ACCCCAAATT TTACCTATGT TTGGAAGATG GGGTTAAAAG GACACATTGA AAACAAGAAC TCATTGTGGC TTTTTTTTCC TCCTTTTTGA EPI-109 1 17

ACAGTTTTCT ATTTCTGGAA TGTTGTCAAT TATATCTGAA AGGAGAAATG CAACATATCT GGTGAGTTGC CCGTTTCTGT CTTTGTCCAT CCTTGAAAAG ATAAGAAGAA CAGAGTTTTA AGAGTCTTAA GGGAAACACA TCTTTGTCTC CTATATTACT TGTGAATGTG GATATATGAT TTTGTTTCAA TCTATTTTGT GTCCTAAGGC TTTTTGCAAC AGAAGTTGGA TATATCATTA GAAACATAAA TTGTACCATT TAACATACAT GAAGTTTATG TTTACCTTGA CGTTCTTCTA AAAAGTGTCC TACACCGGCA TTGTCCTTGT AGGCATATTC ACATGATCAA ATAAAATAAT TAGTTTTCAA TTAAGGAGAA TATTTGAGGA AAGACCGTAC GTGTTCATGT GGTTCCTGAA GGCAGTCCAG TGAGAAAGTA ATATATGCTT CATTAAACAA TGCGGACATT TTCAGGGTTT CCCTTTTTAA CCAAAATTTG GAAGCAATGT GGAATTTACT GGATGCATCC AGCCCTGAAA TGAAGATAGG TTTATTGAAT GTGCCAGCAA GTGCAGGCCC AGGTCTGAGT GTTCTTCATT ATTATCAGGT GAGAGGAAGC CTGGGAGCAA ACACTGCCAG CAGCATAGCT GGGGGAACGG GAATTACCAT CCTGATCATC AACCTGAAGA AGAGCTTGGC CTATATCCAC ATCCACAGTT GCCAGAAATT TTTTGAGACC AAGTGCTTTA TGGCTTCCTT TTCCACTGTA TGTATTTTTT TTTGTGTGGG AAGACTAAGA TTCTGGGTCC TAATGTAAGT AAGAAGCCCT CTTCTCCTGT TCCATGAACA CCATCCTTTT CTGTAACTTC TATTACACAG TATAGTGGTT CTGTAAGTTC ACACAGCCCA GGGAGATGCT GGCTGCCCAC TCCCCTCAAC CCAGGCAAAT TCCTCGGGGT TAAAGTTATC TACTGCAAGT GACGATCTCT GGGTTTTTCT GTGCCTGTGT TTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTATGTGTCA CTTTAAAAGG ACTGGTCAGA TGGTAGGGAG ATGAAAACAG GAGATGCTAT AAGAAAATAA ACTTTTGGGG CGAATACCAA TGTGACTCTT TTTGTTTGTC ATTTGTTGCT GTTCAATAGG AAATTGTAGT GATGATGCTG TTTCTCACCA TTCTGGGACT TGGTAGTGCT GTGTCACTCA CAATCTGTGG AGCTGGGGAA GAACTCAAAG GAAACAAGGT AGATAGAAGC CCGATATAAA ATCTTGAATG ACAGGTTAAC GAATTGGAGC TTTATTCCTT AAAATATGGC CTGGGTTTTC TGAAACATTT CTTCCAGAAA ATAGTTTCTC CAAGTTTTAT TACTTTGGTT TACAAATCTC ACATTTAAAT CACATTTTAT ACCATAAGTA GCACACATTT CATAATATTC CTCTGAATGA GGGTTGGGAT AATAGGACTG ATATGTTAGA AATGCCTTAA AGTGTGTGGA GCATGAGAGA TGGATGTACA GAAGGCTTGT GAGGAAACCA CCCAGGTATC TGGCCTTGTT TTCTGCCCCA GAACTAGCCG CCTATTCCTG TTTCTGTTTT ATTCCTTTGT TTCTTGACTT TTCCTTTCCA ACTTGCTCTA AAACCTCAGT TTTCTITCCT TTCTGATTCA TGACTACCAA ATGTTTTCAC TTGCCTCACC CGTCCATTAC ACCTTTGATA AGAACCACCA GACCTTGTGC TCATGTACTT GCCCATGTCT GATGGAAGAA ACATACTCTC TCCATCTGTC CACTTTCCTG AGGCATTCAA GTCTAGCCAC CTTTTAAAAT CACTCTCCTC CAGGCTGGGC ACGGTGTCAC GCCTGTAATC TCAGCACTTT GTGAGGCTGA GGAGGGCGGA TCACTTGAAG TCAGGAGTTC AAAACCAGCC TGGCCAAATG GCAAAACCAA ATCTTCTTCA ATTATAACCA AATCTTAAAC CAAATCTCTA CTAAAAAATA CAACAAAACA AAACAACAAC AACAAAAACA GAAAAGGAAA CATTAGCCCA GCGTGGTGGC AGGTACCTGA GGTTCCAGAT ACTTGGGAGG CTGAAGCAGG AGAATCGCTT GAGCCCAAGA GATGGAGGTT GCAGTGAGCC GAGATCATGC CACTGCACCA CAGCCAGGGT GACAGAGCCA TACTTCCCAG CACATTGGGA GGCCAAAGCT GAAGAATAAT TTGAGGTGAG GATTTGGAGA CCAGCCTGGC CAACATGGTG AAACTCCGTC TGTACTAAAA ATATAAAACT TAGTGGGGCA TGGGGGCACA CACCTGTAAT TTCAGCTACT TAGGAGGCTG AGGCAGGAGA ATTGCTTGAA CCCGGGAGGC GGAAGTTGCA GTGAGCCAAG ATCGTGGCCA CTGCACTCCA GCCTGGGTGA CATAGTGAGA TTCTGTCTCA AAAAAAATAA AAGAAATTTA AAAAATCACT CTCTTCCAAA GATAGATAAA TAAGACAGCA GATATACTAA GGAATAACCT CACCAACTTC TCATTGACTG ACATGATTTC TTTTGGCCCA CTTGGCCAGC TAGTCTGGTT TGGTTTTCTG GAAATGAAAG AAATAATCAG AGTTTAATGA CAGAGAGCGT GAGACCCAGA AAGACAAAAG TAGATGAGGT AAGTCTCTTG AGCGAGACTT CTAGGGATGG GAAATTTGTG GTGATTGATA TGAAATGATT TTTCCCTTAT CAGGTTCCAG AGGATCGTGT TTATGAAGAA TTAAACATAT ATTCAGCTAC TTACAGTGAG TTGGAAGACC CAGGGGAAAT GTCTCCTCCC ATTGATTTAT AAGAATCACG TGTCCAGAAC ACTCTGATTC ACAGCCAAGG ATCCAGAAGG CCAAGGTTTT GTTAAGGGGC TACTGGAAAA ATTTCTATTC TCTCCACAGC CTGCTGGTTT TACATTAGAT TTATTCGCCT GATAAGAATA TTTTGTTTCT GCTGCTTCTG TCCACCTTAA TATGCTCCTT CTATTTGTAG ATATGATAGA CTCCTATTTT TCTTGTTTTA TATTATGACC ACACACATCT CTGCTGGAAA GTCAACATGT AGTAAGCAAG ATTTAACTGT TTGATTATAA CTGTGCAAAT ACAGAAAAAA AGAAGGCTGG CTGAAAGTTG AGTTAAACTT TGACAGTTTG ATAATATTTG GTTCTTAGGG TTTTTTTTTT TTTTAGCATT CTTAATAGTT ACAGTTGGGC ATGATTTGTA CCATCCACCC ATACCCACAC AGTCACAGTC ACACACACAT ATGTATTACT TACACTATAT ATAACTTCCT ATGCAAATAT TTTACCACCA GTCAATAATA CATTTTTGCC AAGACATGAA GTTTTATAAA GATCTGTATA ATTGCCTGAA TCACCAGCAC ATTCACTGAC ATGATATTAT TTGCAGATTG ACAAGTAGGA AGTGGGGAAC TTTTATTAAG TTACTCGTTG TCTGGGGAGG TAAATAGGTT AAAAACAGGG AAATTATAAG TGCAGAGATT AACATTTCAC AAATGTTTAG TGAAACATTT GTGAAAAAAG AAGACTAAAT TAAGACCTGA GCTGAAATAA AGTGACGTGG AAATGGAAAT AATGGTTATA TCTAAAACAT GTAGAAAAAG AGTAACTGGT AGATTTTGTT AACAAATTAA AGAATAAAGT TAGACAAGCA ACTGGTTGAC TAATACATTA AGCGTTTGAG TCTAAGATGA AAGGAGAACA CTGGTTATGT TGATAGAATG ATAAAAAGGG TCGGGCGCGG AGGCTCACGC CTGTAATCCC AGCCCTTTGG GAGGCCGAGG TGGGCAGATC ACGAAGTCAG TAGTTTGAGA CCAGCCTGGC CAACATAGTG AAACCCCGTC TCTACTAAAA ATACAAAAAA AAAATTAGCT GGGTGTGGTG GCAGTCACCT GTAGTCCCAG CTACTTGGGA GGATGAGGCA GGAGAATCGC TTGAACCTGG GAGGCGGAGG TTGCAGTGAG CCGAGATCGC ACCAGTGCAC TCCAGCCTTG GTGACAATGG GAGACTCCAT CTCAAAAAAA AAAAAAAAAA AAAAAAGATA AAAAGTCAGA AATCTGAAAA GTGGAGGAAG AGTACAAATA GACCTAAATT AAGTCTCATT TTTTGGCTTT GATTTTGGGG AGACAAAGGG AAATGCAGCC ATAGAGGGCC TGATGACATC CAATACATGA GTTCTGGTAA AGATAAAATT TGATACACGG TTTGGTGTCA TTATAAGAGA AATCATTATT AAATGAAGCA AGTTAACACT CTAAGAGAAT TATTTTGAGA TAGAAGTGAA GCTAAGCTAA ACTTCACATG CCTATAATTG GAGGGAAAAA CTAAGGATAA AATCTAGCCT AGAAGATACA ATAATTAGTC ATAAACATGC ATTGTGAAAC TGTAGAGAGC AGGTAGCCCA AAATAGAGAA AGATTAGATA AAGAGAAAAT AAGTATCCAT CAGAGACAGT ATCTCTAGGC TTGGGCAAGA GAAAAGTCCA CAGTGATAAG CAACTCCACC TAAGGCATGA ATATGCGGCA GAGAAAACAG CAATAGTGAA TGAATGCAAA AGGTGCTGAG CAAATTCCAC ACATGAGTAT TGTGCATGAG TAAATGAATA AAACATTTGC AAAGACCTTT AGAGAAAGAG AATGGGAGCA TATGTGCGAA ATAAGATAGT TGATTATGAA TAGAAGGTAG TGAAGAAAAG CAAGCTAAGA AAAAATTCTG TTTATAAAAG AAGGAAAAGA TAGTTTATGT TTTTAGCCTA AGTATAAGAG TCCTACAGAT GGACTGAAAA AAATCAGTCT GAGAGTATTA GTCACAATTA ATGAAATAAT TACATTTTAT GTATTGAGGA TGCCAAGATT AAAAGGTGAC AGGTAGATGT TAATTTCCCT AGATTGTGAA AGTGATCACG ACAATCACAC AACAAATAAT TAAGTGACTT GGTATGCTTT ATTTAATTGT AGGGCCTGAG GTTTTCCATT CTCATTTTTC TAAAATACAA TTTTGTTTCT CCAAATTTGA CAGCAGAATA AAAACCCTAC CCTTTCACTG TGTATCATGC TAAGCTGCAT CTCTACTCTT GATCATCTGT AGGTATTAAT CACATCACTT CCATGGCATG GATGTTCACA TACAGACTCT TAACCCTGGT TTACCAGGAC CTCTAGGAGT GGATCCAATC TATATCTTTA CAGTTGTATA GTATATGATA TCTCTTTTAT TTCACTCAAT TTATATTTTC ATCATTGACT ACATATTTCT TATACACAAC ACACAATTTA TGAATTTTTT CTCAAGATCA TTCTGAGAGT TGCCCCACCC TACCTGCCTT TTATAGTACG CCCACCTCAG GCAGACACAG AGCACAATGC TGGGGTTCTC TTCACACTAT CACTGCCCCA AATTGTCTTT CTAAATTTCA ACTTCAATGT CATCTTCTCC ATGAAGACCA EPI-109 1 18

CTGAATGAAC ACCTTTTCAT CCAGCCTTAA TTTCTTGCTC CATAACTACT CTATCCCACG ATGCAGTATT GTATCATTAA TTATTAGTGT GCTTGTGACC TCCTTATGTA TTCTCAATTA CCTGTATTTG TGCAATAAAT TGGAATAATG TAACTTGATT TCTTATCTGT GTTTGTGTTG GCATGCAAGA TTTAGGTACT TATCAAGATA ATGGGGAATT AAGGCATCAA TAAAATGATG CCAAAGACCA AGAGCAGTTT CTGAAGTCCT CCTTTTCATC AGCTCTTTAT CAAACAGAAC ACTCTATAAA CAACCCATAG CCAGAAAACA GGATGTAGGA ACAATCACCA GCACACTCTA TAAACAACCC ATAGCCAGAA AACAGAATGT AAGGACAATC ACCAGCCATC TTTTGTCAAT AATTGATGGA ATAGAGTTGA AAGGAACTGG AGCATGAGTC ATATTTGACC AGTCAGTCCT CACTCTTATT TACTTGCTAT GTAAACTTGA GAAAGCTTTT TTCTCTTTGT GAACCTCAGG TTTTACATCT GAAAATGAGA AATTTGGAAC AAAAGATTCC TAACTGGTCT TTCTGTTCCC ATATTCTGTG ATTTTTCAAT ATTTAGGATT TTTGGTAATC ACAATTACTT AGTTTGTGGT TGAGATAGCA ACACGAATCA GAACTATTTG GTGGACATAT TTTCAAAGGA GTAGCTCTCC ACTTTGGGTA AAGAAGTGAT GCNGGTCGTG GTGGCTCACG CCTGTAATCC CAGCACTTTA GGGAGGCCAA GGCGGGTGGA TCACGAGGTC AGGAGATCGA GACCATCCTG GCTAACACGG TGAAACCCCG TCTCTACTAA AAAATACAAA AAATTAGCCA GGCGTGGTGG CGGGCGCCTG TAGTCCCACG TACTCGGGAG GCTGAGGCAG GAGAATGGCA TGAACCAGGG AGGCGGAGCT TGCCGTGAGC CGAGATAGCG CCACTGCAGT CCCTCCTGGG CAAAAGAGCA AGACTGCGTC TCAAAAAAAA AAAAAAAAAA AAAAAAAGAA GTGTGTGGAG TAGCAGGACA CCTGCAACAA TAATATTTTT CTAAATCCCT CTGAAAAATG CTAATCAAAG GGTTTTTTTC CTAAAAATTG TCTTAGAAAT AAAATTTCCC CTTTGGGAGA CCGAGGCTGG CAGATCACGA GGTCAGGAGA TAGAGACCAC GGTGAAACCC CGTCTCTACT AAAAATACTA AAAATTAGCC GGGGNGTGGT GGTGGGTACA CCTGTAGTCC CAGCTACTTG GAGGCTGAGG CTGGAGAATC ACGTGAAC-3' (FRAG. NO:_)(SEQ. ID NO:2504)

Human Histidine Decarboxylase Nucleic Acid and Antisense Oligonucleotide Fragments

5'-TCT CCC TTG GGC TCT GGC TCC TTC TC TCT CTC TCC CTC TCT CTC TGT CGC CTC CGC CCT GGC TGC TGG GGT

GGT GGT GC TTT TGT TCT TCC TTG CTG CC GCC CCG CTG CTT GTC T TC CTC G CTC TGT CCC TCT CTC TCT GTB CTC

CTC BGG CTC CBT CBT CTC CCT TGG GC-3' (FRAG. NO:1700) (SEQ. ID NO:1711)

5 -GGC TCT GGC (FRAG. Nθ:1701) (SEQ. ID NO: 1712)

5 -CCC TTG G (FRAG. NO:1702) (SEQ. ID NO: 1713)

5'- TT TGT TCT TCC (FRAG. NO:1703) (SEQ. ID NO: 1714)

5'- TCT CCC TTG GGC TCT GGC TCC TTC TC-3' (FRAG. NO:1024) (SEQ. ID NO: 1034)

5'- TCT CTC TCC CTC TCT CTC TGT -3' (FRAG. NO:1025) (SEQ. ID NO:1035)

5'- CGC CTC CGC CCT GGC TGC TGG GGT GGT GGT GC-3' (FRAG. NO:1026) (SEQ. ID NO:1036)

5'- TTT TGT TCT TCC TTG CTG CC-3' (FRAG. NO:1027) (SEQ. ID NO:1037)

5'- GCC CCG CTG CTT GTC T TC CTC G-3' (FRAG. NO:1028) (SEQ. ID NO:1038)

5'-CTC TGT CCC TCT CTC TCT GTB CTC CTC BGG CTC CBT CBT CTC CCT TGG GC (FRAG. NO:1029) (SEQ. ID NO:1039)

Human Beta Tryptase Nucleic Acid and Antisense Oligonucleotide Fragments

5 ' CTT GCT CCT GGG GGC CTC CTG GTC CCT CCG GGT GTT CCC GGC GGG CCT GGC CTG GGG CBG GGG CCG CGT BGG

CGC GGC TCG CCB GGB CGG GCB GCG CCB GCB GCB GCB GBT TCB GCB TCC TGG-3' (FRAG. NO:1704) (SEQ. ID NO:

1715)

5 - GCT CCT GGG GGC CT-3' (FRAG. NO: 1705) (SEQ. ID NO: 1716)

5 -CGT BGG CGC-3' (FRAG. NO:1706) (SEQ. ID NO: 1717)

5'-T GGC CTG GGG-3' (FRAG. NO:1707) (SEQ. ED NO: 1718)

5'-CTT GCT CCT GGG GGC CTC CTG-3' (FRAG. NO:1030) (SEQ. ID NO:1040)

5'-GTC CCT CCG GGT GTT CCC GGC-3' (FRAG. NO:1031) (SEQ. ID NO:1041)

5'-GGG CCT GGC CTG GGG CBG GGG CCG CGT BGG CGC GGC TCG CCB GGB CGG GCB GCG CCB GCB GCB GCB GBT TCB

GCB TCC TGG-3' (FRAG. NO:1032) (SEQ. ED NO:1042)

Human Trvptase-I Nucleic Acid and Antisense Oligonucleotide Fragments

5'-CTT GCT CCT GGG GGC CTC CTG GTC CCT CTG GCT G TT CCC GGC CCT GGB CTG GGG CBG GGG CCG CGT BGG CGC

GGC TCG CCB GGB CGG GCB GCG CCB GCB GCB GCB GGC TCB GCB TCC TGG CCB CGG BBT TCC-3' (FRAG. NO: 1708)

(SEQ. ED NO:1719)

5'-CT CCT GGG GGC CTC CTG-3' (FRAG. NO:1709) (SEQ. ED NO:1720)

5'-B TCC TGG CCB CGG BBT TCC -3' (FRAG. NO:1710) (SEQ. ID NO:1721)

5'-GTC CCT C-3' (FRAG. NO:1711) (SEQ. ID NO:1722)

5'-CTT GCT CCT GGG GGC CTC CTG-3' (FRAG. NO:1033) (SEQ. ID NO:1043)

5'-GTC CCT CTG GCT G TT CCC GGC-3' (FRAG. NO:1034) (SEQ. ID NO:1044)

5'-CCT GGB CTG GGG CBG GGG CCG CGT BGG CGC GGC TCG CCB GGB CGG GCB GCG CCB GCB GCB GCB GGC TCB GCB

TCC TGG CCB CGG BBT TCC -3' (FRAG. NO:1035) (SEQ. ID NO:1045)

Human Prostaglandin D Svnthase Nucleic Acid and Antisense Oligonucleotide Fragments

5'-GGT GTG CGG GGC CTG GTG CC CCT GGG CCT CGG GTG CTG CCT GT GCG CTG CCT TCT TCT CCT GG GTC CTC GCC

GGG GCC CTT GCT GCC CTG GCT GT GCC CTG GGG GTC TGG GTT CGG CTG T CCC CBG CBG GBC CBG TCC CBT CCB

CBG CGT GTG BTG BGT BGC CBT TCT CCT GCB GCC GBG-3' (FRAG. NO:1712) (SEQ. ID NO:1723)

5'-T TCT CCT GCB GCC GBG -3' (FRAG. NO:1713) (SEQ. ID NO:1724)

5'-CTT GCT GCC CTG GCT GT-3' (FRAG. NO:1714) (SEQ. ID NO:1725)

5'- TCT TCT CCT GG-3' (FRAG. NO:1715) (SEQ. ED NO:1726)

5'-GGT GTG CGG GGC CTG GTG CC-3' (FRAG. NO:1036) (SEQ. ID NO:1046)

5'-CCT GGG CCT CGG GTG CTG CCT GT-3' (FRAG. NO:1037) (SEQ. ID NO:1047)

5'-GCG CTG CCT TCT TCT CCT GG-3' (FRAG. NO:1038) (SEQ. ID NO:1048)

5'-GTC CTC GCC GGG GCC CTT GCT GCC CTG GCT GT-3' (FRAG. NO:1039) (SEQ. ID NO:1049)

5'-GCC CTG GGG GTC TGG GTT CGG CTG T-3' (FRAG. NO:1040) (SEQ. ED NO:1050)

5'-CCC CBG CBG GBC CBG TCC CBT CCB CBG CGT GTG BTG BGT BGC CBT TCT CCT GCB GCC GBG -3' EPI-109 1 19

(FRAG. NO:1041) (SEQ. ED NO:1051)

Human Cvclooxygenase-2 Nucleic Acid and Antisense Oligonucleotide Fragments

5'-GGG CGC GGG CGB GCB TCG C TTT GGG CTT TTC TCC TTT GGT T TGB GCG CCB GGB CCG CGC BCB GCB GCB GGG CGC GGG CGB GCB TCG CBG CGG CGG GCB GGG-3' (FRAG. NO: 1716) (SEQ. ED NO:1727) 5 -G GCB GGG -3' (FRAG. NO: 1717) (SEQ. ED NO: 1728) 5'-TCC TTT GGT T-3' (FRAG. NO:1718) (SEQ. ED NO:1729) 5'- GGG CGC GGG CGB GCB TCG C-3' (FRAG. NO:1042) (SEQ. ID NO.-1052) 5'- TTT GGG CTT TTC TCC TTT GGT T-3' (FRAG. NO:1043) (SEQ. ID NO:1053)

5'-TGB GCG CCB GGB CCG CGC BCB GCB GCB GGG CGC GGG CGB GCB TCG CBG CGG CGG GCB GGG -3' (FRAG. NO:1044) (SEQ. ED NO:1054)

Human Eosinophil Cationic Protein Nucleic Acid and Antisense Oligonucleotide Fragments

5'-CCT CCT TCC TGG TCT GTC TGC CBG BCB BBT TTG GGB BGT GBB CBG TTT TGG BBC CBT GTT TCC CBG TCT CTG

BGC TGT GGC-3' (FRAG. NO: 1719) (SEQ. ID NO: 1730)

5'-TTC TCC TTT GGT T-3' (FRAG. NO:1720) (SEQ. ID NO: 1731)

5'-T TTC TCC TTT GGT T-3' (FRAG. NO:1721) (SEQ. ID NO:1732)

5'- GGG CGC GGG CGB GCB TCG C-3' (FRAG. NO:1042) (SEQ. ID NO:1052)

5'- TTT GGG CTT TTC TCC TTT GGT T-3' (FRAG. NO:1043) (SEQ. ID NO:1053)

5'-TGB GCG CCB GGB CCG CGC BCB GCB GCB GGG CGC GGG CGB GCB TCG CBG CGG CGG GCB GGG -3'

(FRAG. NO:1044) (SEQ. ID NO:1054)

Human Eosinophil Derived Neurotoxin Nucleic Acid and Antisense Oligonucleotide Fragments

5'-GCC CTG CTG CTC TTT CTG CT TCC CTT GGT GGG TTG GGC C GCT GGT TGT TCT GGG GTT C TTG CTG CCC CTT CTG TCC C TGT TTG CTG GTG TCT GCG C 5'- CCC CBB CBG BBG BBG CBG BCB BBT TTG GGB BGT GBB CBG TTT TGG BBC CBT GTT TCC TGT-3'

(FRAG. NO: 1722) (SEQ. ID NO: 1733) 5'-TTC CTG T-3' (FRAG. NO:1723) (SEQ. ID NO: 1734) 5'-CTC TTT CTG CT-3' (FRAG. NO: 1724) (SEQ. ID NO:1735) 5' -CCC CTT CTG TCC C-3' (FRAG. NO: 1725) (SEQ. ID NO: 1736) 5'- GCC CTG CTG CTC TTT CTG CT-3' (FRAG. NO:1047) (SEQ. ID NO:1057) 5'- TCC CTT GGT GGG TTG GGC C-3' (FRAG. NO:1048) (SEQ. ID NO:1058) 5'- GCT GGT TGT TCT GGG GTT C-3' (FRAG. NO:1049) (SEQ. ID NO.-1059) 5'- TTG CTG CCC CTT CTG TCC C-3' (FRAG. NO:1050) (SEQ. ID NO:1060) 5'- TGT TTG CTG GTG TCT GCG C -3' (FRAG. NO:1051) (SEQ. ID NO:1061) 5'- CCC CBB CBG BBG BBG CBG BCB BBT TTG GGB BGT GBB CBG TTT TGG BBC CBT GTT TCC TGT-3' (FRAG. NO:1052)

(SEQ. ID NO:1062)

Human Eosinophil Peroxidase Nucleic Acid and Antisense Oligonucleotide Fragments

5' -GCG CTC GGC CTG GTC CCG G GGG TCT CCT CTT GTT GTT GC TTG CGC CTC CTG CTG GGG GT CC CTC TGT TCT TGT TTT GGG GGC GGG CCC GGC CGT TGT CTT G GTT TGG GGG TTT CCG TTG GGG TTC TCC TGG CCC GGG CCT TGC CC GGC CGT GGT CCC GGC TTC GTTCCT GTC TCC GTC TCG GCT CTT CTG GGG CCT TGC GCT GTC TTT GGT G 5'-GCB CCG TCC BGT GBT GGT GCG GTB CTT GTC GCT GCB GCG CTC GGC CTG GTC CCG GBG BGC CACCGCTCCT GTCAGCCAAC AAATATCCAT TGAGCGACAC CTGTGTCCCA GGTGCTGCTC TGGGCCCTGG GAGAAGTGCA TCAGTGGGCT TGGTAGTAGA GGGTAGGGAT GGAGTGAAGG GTAGGCAGGA AGAATGTCCC CAGGCTGGTA GGAGGTGGGG TGGGGGGTTT CAGTCTCAAA ACTCCCATGA AAACCAGAGA GAAGTTTCAG AACTCCACCC AAGAGGCTGG GTTTCTAGGG CCCAGAGCTG CCCTCCCCCA CCCTAGAATG GGCTATAAAA GTCCCTTCCC AGCTACGTCC AGAGAAGAGC TGGAGGAAGT GAGAGGTCGG CTGGGGGTCC TCAAAGTGAG AGGGGAGCAG AGGATCCTCC CGTGCAGGCT GTGGATGTCA CTCACTTCCC AGCTGGTGAA GCCTCGCTGC AGAGATGCAT CTGCTCCCAG CCCTGGCAGG GGTCCTGGCC ACACTCGTCC TCGCCCAGCC CTGTGAGGGC ACTGACCCAG GTAATAGTCC CCTAGACAGG CAAGGAGGAG GGAGGGGAAA TGGAAGGGGA AGCACTTGGG TCTTGGAGGG GGTCTTGTGG CTTGCTGAAC CCTGAGTCCC CATCTCTTTG AACAGCCTCC CCTGGGGCAG TGGAGACCTC GGTCCTGCGA GACTGCATAG CAGAGGCCAA GTTGCTGGTG GATGCTGCCT ACAATTGGAC CCAGAAGAGG TGGACTTGGG TCTGGGGGCT GCATGGGCCT GGGAGGATCA GT TAATACCTTG TGGGGTCAGG GAGCCCATGT CCCGTGCTGA TGTTATTTCC CCACCAGGTC CGGGCTGTCT CCAACCAGAT TGTGCGCTTC CCCAATGAGA GACTGACCTC CGACCGTGGC CGAGCCCTCA TGTTCATGCA GTGGGGCCAG TTCATTGACC ATGACCTGGA CTTCTCCCCG GAGTCCCCGG CCAGAGTGGC CTTCACTGCA GGCGTTGACT GTGAGAGGAC CTGCGCCCAG CTGCCCCCCT GCTTTCCCAT CAAGGTACCT ACCCTCAGCC AATCTCCCAT GCCCTTGTGT GGCCTCCCCC AAAGGCAAGG TGCTGGGGGT GGGGATCTGG AAGACTGGAG CACCATCCTT AAGGAGCTGC CTGTGGAGCT AGGGTATGAG ACAGAGACAC AAG CACTGTCTCC TCTTCCATCT CAGATCCCAC CCAATGACCC CCGCATCAAG

AACCAGCGTG ACTGCATCCC TTTCTTCCGC TCGGCACCCT CATGCCCCCA AAACAAGAAC AGAGTCCGCA ACCAGATCAA CGCGCTCACC TCCTTTGTGG ACGCCAGCAT GGTGTATGGC AGTGAGGTCT CCCTCTCGCT GCGGCTCCGC AACCGGACCA ACTACCTGGG GCTGCTGGCC ATCAACCAGC GCTTTCAAGA CAACGGCCGG GCCCTGCTGC CCTTCGACAA CCTGCACGAT GACCCCTGTC TCCTCACCAA CCGCTCGGCG CGCATCCCCT GCTTCCTGGC AGGTCAGACA GGGAGGAAGG TGGTGTCTTC CCAGGAAACA GCCATCCCTC GGGTCCCAAC TGGGAAGCAA TGGTGGGATG TGGTGAAGGT ACATGGTTTG GGACCTCAGT ATTAGGCACA CCATAAGCAT GGATCTGTGC AC TGAAGAGATG GAGGTCCAGT GAGGGCCAGG AGTTTGGCCC ACCCCGTCTC TCCCATCCCC AGCCCTGGGT CTACCCTGGT AGAAAGACAT TTCTCTGGGA AAGGCTGCAG TAAATCTGAG CTTGGGGTTT TCAAGGTGAC ACCCGATCAA CGGAAACCCC CAAACTGGCA GCCATGCACA CCCTCTTTAT GCGAGAGCAC AACCGGCTGG CCACCGAGCT GAGACGCCTG AATCCCCGGT GGAATGGAGA CAAACTGTAC AATGAGGCTC GGAAGATCAT GGGGGCCATG GTCCAGGTAA GGAGCTCTGC ATCCCAGCAT CCCCC CTTTGTATCT CCACCCACCA ATAGTAAATT AATGTTGTCA CATTTGACGT GATGACAATA AAGAATATGT CTGAGCCACC CTTTGAAAAG GCAAGGGTAT GGGTGAGTAG CCTCTGGGGA ATGTTCCTCC TGTCTTCCCT TCCAGATCAT CACCTACCGA GACTTTCTGC CCCTGGTTCT GGGCAAGGCC CGGGCCAGGA GAACCCTGGG GCACTACAGG GGGTACTGCT CCAATGTGGA CCCACGGGTG GCCAATGTCT TCACCCTGGC EPI-109 120

CTTCCGCTTT GGCCACACAA TGCTCCAGCC CTTCATGTTC CGCTTGGACA GTCAGTACCG GGCCTCCGCA CCCAACTCGC ATGTCCCACT TAGCTCTGCC TTCTTTGCCA GCTGGCGGAT CGTGTATGAA GGTGACCAGG TTTTCCAGGG GGCAAATGGG GGTGAGGGTG GGGAGCATGC CCTCCCCTAG GTGG TCCAGCTGCT TCATGTCTCT CCAGAACTCT GTTTCCTGAC AAACGTTACT AACATACCCG ACTGGCTTGT CCAGCTCTGG GCTAGCTTGG CATCATGTGA TAACCCAAGT AGCTTCCCAG AGGCTGGTCC AATCTGTGCT GCTCACATTC CCTGCCACCA GGGGGCATCG ACCCCATCCT CCGGGGCCTC ATGGCCACCC CTGCCAAGCT GAACCGTCAG GATGCCATGT TAGTGGATGA GCTCCGGGAC CGGCTGTTTC GGCAAGTGAG GAGGATTGGG CTGGACCTGG CAGCTCTCAA CATGCAACGA AGCCGGGACC ACGGCCTTCC AGGTGAGGGG GCTGTCCACC TCTTCTCCCA GCTTTGCTCG GGCCAGGCTG CTCAAGGGGT TCTGGGAAGA CCCTGGTACC CGACTGCCTG GTAGGTTCTG GTGGCAGAAA CGAGGTGTTT TCACCAAAAG ACAGCGCAAG GCCCTGAGCA GAATTTCCTT GTCTCGAATT ATATGTGACA ATACCGGTAT CACCACGGTT TCAAGGGACA TCTTCAGAGC CAACATCTAC CCTCGGGGCT TTGTGAACTG CAGCCGTATC CCCAGGTTGA ACCTATCAGC CTGGCGAGGG ACATGAGGCT TCTGCAGGTA AGGGGAGGCC ACCTCCAGCA CCCTGGGCTG GTTAAGCCTC ACATCCTTCC CTGGATGGAT GGCTGAGTCC TCTTAGGTCT CTAAGCAGAG AAAACAGAAC TTGTCACTAG GTACTCTTTC CAAGTGGCTT CCCAATGTGC TAGTTTCTGG GCTGACAGTC AATTCCAGGC CCTAGGACTT TGGGGGGAAA TTAGGAGCAT CCAACTA GAATTCCGTG GCCAGGACCC CTGCCAGGGC ACTGACCCAG CCTCCCCTGG GGCAGTGGAG ACCTCGGTCC TGCGAGACTG CATAGCAGAG GCCAAGTTGC TGGTGGATGC TGCCTACAAT TGGACCCAGA AGAGCATCAA GCAGCGGCTT CGCAGCGGTT CAGCCAGCCC CATGGACCTC CTGTCCTACT TCAAACAACC GGTAGCAGCC ACCAGGACAG TTGTTCGGGC CGCAGATTAT ATGCATGTGG CTTTGGGGCT GCTTGAAGAG AAGTTACAAC CCCAGCGGTC CGGACCCTTC ATTGTCACTG ATGTGCTAAC AGAACCACAG CTGCGGCTGC TGTCCCAGGC CAGTGGCTGT GCTCTCCGGG ACCAGGCCGA GCGCTGCAGC GACAAGTACC GCACCATCAC TGGACGGTGC AACAACAAGA GGAGACCCTT GCTAGGGGCC TCCAACCAGG CTCTGGCTCG CTGGCTGCCC GCCGAGTATG AGGATGGGCT GTCGCTCCCC TTCGGCTGGA CCCCCAGCAG GAGGCGCAAT GGCTTCCTTC TCCCTCTTGT CCGGGCTGTC TCCAACCAGA TTGTGCGCTT CCCCAATGAG AGACTGACCT CCGACCGTGG CCGAGCCCTC ATGTTCATGC AGTGGGGCCA GTTCATTGAC CATGACCTGG ACTTCTCCCC GGAGTCCCCG GCCAGAGTGG CCTTCACTGC AGGCGTTGAC TGTGAGAGGA CCTGCGCCCA GCTGCCCCCC TGCTTTCCCA TCAAGATCCC ACCCAATGAC CCCCGCATCA AGAACCAGCG TGACTGCATC CCTTTCTTCC GCTCGGCACC CTCATGCCCC CAAAACAAGA ACAGAGTCCG CAACCAGATC AACGCGCTCA CCTCCTTTGT GGACGCCAGC ATGGTGTATG GCAGTGAGGT CTCCCTCTCG CTGCGGCTCC GCAACCGGAC CAACTACCTG GGGCTGCTGG CCATCAACCA GCGCTTTCAA GACAACGGCC GGGCCCTGCT GCCCTTCGAC AACCTGCACG ATGACCCCTG TCTCCTCACC AACCGCTCGG CGCGCATCCC CTGCTTCCTG GCAGGTGACA CCCGATCAAC GGAAACCCCC AAACTGGCAG CCATGCACAC CCTCTTTATG CGAGAGCACA ACCGGCTGGC CACCGAGCTG AGACGCCTGA ATCCCCGGTG GAATGGAGAC AAACTGTACA ATGAGGCTCG GAAGATCATG GGGGCCATGG TCCAGATCAT CACCTACCGA GACTTTCTGC CCCTGGTTCT GGGCAAGGCC CGGGCCAGGA GAACCCTGGG GCACTACAGG GGGTACTGCT CCAATGTGGA CCCACGGGTG GCCAATGTCT TCACCCTGGC CTTCCGCTTT GGCCACACAA TGCTCCAGCC CTTCATGTTC CGCTTGGACA GTCAGTACCG GGCCTCCGCA CCCAACTCGC ATGTCCCACT TAGCTCTGCC TTCTTTGCCA GCTGGCGGAT CGTGTATGAA GGGGGCATCG ACCCCATCCT CCGGGGCCTC ATGGCCACCC CTGCCAAGCT GAACCGTCAG GATGCCATGT TAGTGGATGA GCTCCGGGAC CGGCTGTTTC GGCAAGTGAG GAGGATTGGG CTGGACCTGG CAGCTCTCAA CATGCAACGA AGCCGGGACC ACGGCCTTCC AGGGTACAAT GCTTGGAGGC GCTTCTGTGG GCTCTCCCAG CCCCGGAATT TGGCACAGCT TAGCCGGGTG CTGAAAAACC AGGACTTGGC AAGGAAGTTC CTGAATTTGT ATGGAACACC TGACAACATT GACATCTGGA TTGGGGCCAT CGCTGAGCCT CTTTTGCCGG GGGCTCGAGT GGGGCCTCTT CTGGCTTGTC TGTTCGAGAA CCAGTTCAGA AGAGCCGAGA CGGAGACAGG TTCTGGTGGC AGAACGAGGT GTTTTCACCA AAGACAGCGC AAGGCCCTGA GCAGAATTTC CTTGTCTCGA ATTATATGTG ACAATACCGG TATCACCACG GTTTCAAGGG ACATCTTCAG AGCCAACATC TACCCTCGGG GCTTTGTGAA CTGCAGCCGT ATCCCCAGGT TGAACCTATC AGCCTGGCGA GGGACATGAG GCTTCTGCAG GAGTCTATCC CAAGTCTCCA ACTTTTGGAG ACAAGGGGAA GGGGAGGACC ATGAGGCTGC CTTGTCTCCC TGGAGCAAGT GCAGGCTCGT GACGCTTCTG CTGGCTACAG CTCAGAGCTG GGTTCCCCAG CCAGGAGTGA AGGCTGGGGG CTCCTATCAG CAATGGACCT TCCGCCTTGG GAGCCTCTTA GGTATTAGGC TATGAATCAG CGCCACGTGC AAAGGCTTGG GAGCCAAGCC ATGTGGTCTT GCACCCCAGG CAAGAAAAGT CAGCTGGAGG GTTTACAGCA CTTTCTACTG TTTCCCAGCC CTCCCTCCCC TCCCTCACCA TGACTAAGAG ACCACTCGGT CCTAGCCTCC AGACACCCCA CAATACTCCT CTGAGCCTGA GGCCAGGCAG CATGCTCTGC TTCTACCAAT AAAGCACTGC CGGAATTC-3' (FRAG. NO: 1726) (SEQ. ID NO: 1737)

5'-CACCGCTCCT GTCAGCCAAC AAATATCCAT TGAGCGACAC CTGTGTCCCA GGTGCTGCTC TGGGCCCTGG GAGAAGTGCA TCAGTGGGCT TGGTAGTAGA GGGTAGGGAT GGAGTGAAGG GTAGGCAGGA AGAATGTCCC CAGGCTGGTA GGAGGTGGGG TGGGGGGTTT CAGTCTCAAA ACTCCCATGA AAACCAGAGA GAAGTTTCAG AACTCCACCC AAGAGGCTGG GTTTCTAGGG CCCAGAGCTG CCCTCCCCCA CCCTAGAATG GGCTATAAAA GTCCCTTCCC AGCTACGTCC AGAGAAGAGC TGGAGGAAGT GAGAGGTCGG CTGGGGGTCC TCAAAGTGAG AGGGGAGCAG AGGATCCTCC CGTGCAGGCT GTGGATGTCA CTCACTTCCC AGCTGGTGAA GCCTCGCTGC AGAGATGCAT CTGCTCCCAG CCCTGGCAGG GGTCCTGGCC ACACTCGTCC TCGCCCAGCC CTGTGAGGGC ACTGACCCAG GTAATAGTCC CCTAGACAGG CAAGGAGGAG GGAGGGGAAA TGGAAGGGGA AGCACTTGGG TCTTGGAGGG GGTCTTGTGG CTTGCTGAAC CCTGAGTCCC CATCTCTTTG AACAGCCTCC CCTGGGGCAG TGGAGACCTC GGTCCTGCGA GACTGCATAG CAGAGGCCAA GTTGCTGGTG GATGCTGCCT ACAATTGGAC CCAGAAGAGG TGGACTTGGG TCTGGGGGCT GCATGGGCCT GGGAGGATCA GT-3' (FRAG. NO: (SEQ. ID NO:2483)

5'-TAATACCTTG TGGGGTCAGG GAGCCCATGT CCCGTGCTGA TGTTATTTCC CCACCAGGTC CGGGCTGTCT CCAACCAGAT TGTGCGCTTC CCCAATGAGA GACTGACCTC CGACCGTGGC CGAGCCCTCA TGTTCATGCA GTGGGGCCAG TTCATTGACC ATGACCTGGA CTTCTCCCCG GAGTCCCCGG CCAGAGTGGC CTTCACTGCA GGCGTTGACT GTGAGAGGAC CTGCGCCCAG CTGCCCCCCT GCTTTCCCAT CAAGGTACCT ACCCTCAGCC AATCTCCCAT GCCCTTGTGT GGCCTCCCCC AAAGGCAAGG TGCTGGGGGT GGGGATCTGG AAGACTGGAG CACCATCCTT AAGGAGCTGC CTGTGGAGCT AGGGTATGAG ACAGAGACAC AAG-3' (FRAG.NO:J(SEQ.ID NO:2484)

5'-CACTGTCTCC TCTTCCATCT CAGATCCCAC CCAATGACCC CCGCATCAAG AACCAGCGTG ACTGCATCCC TTTCTTCCGC TCGGCACCCT CATGCCCCCA AAACAAGAAC AGAGTCCGCA ACCAGATCAA CGCGCTCACC TCCTTTGTGG ACGCCAGCAT GGTGTATGGC AGTGAGGTCT CCCTCTCGCT GCGGCTCCGC AACCGGACCA ACTACCTGGG GCTGCTGGCC ATCAACCAGC GCTTTCAAGA CAACGGCCGG GCCCTGCTGC CCTTCGACAA CCTGCACGAT GACCCCTGTC TCCTCACCAA CCGCTCGGCG CGCATCCCCT GCTTCCTGGC AGGTCAGACA GGGAGGAAGG TGGTGTCTTC CCAGGAAACA GCCATCCCTG GGGTCCCAAC TGGGAAGCAA TGGTGGGATG TGGTGAAGGT ACATGGTTTG GGACCTCAGT ATTAGGCACA CCATAAGCAT GGATCTGTGC AC-3' (FRAG.NO: (SEQ.ID NO:2485) EPI-109 121

5'-TGAAGAGATG GAGGTCCAGT GAGGGCCAGG AGTTTGGCCC ACCCCGTCTC TCCCATCCCC AGCCCTGGGT CTACCCTGGT AGAAAGACAT TTCTCTGGGA AAGGCTGCAG TAAATCTGAG CTTGGGGTTT TCAAGGTGAC ACCCGATCAA CGGAAACCCC CAAACTGGCA GCCATGCACA CCCTCTTTAT GCGAGAGCAC AACCGGCTGG CCACCGAGCT GAGACGCCTG AATCCCCGGT GGAATGGAGA CAAACTGTAC AATGAGGCTC GGAAGATCAT GGGGGCCATG GTCCAGGTAA GGAGCTCTGC ATCCCAGCAT CCCCC-3' (FRAG.NO:J(SEQ.IDNO:2486)

S'-CTTTGTATCT CCACCCACCA ATAGTAAATT AATGTTGTCA CATTTGACGT GATGACAATA AAGAATATGT CTGAGCCACC CTTTGAAAAG GCAAGGGTAT GGGTGAGTAG CCTCTGGGGA ATGTTCCTCC TGTCTTCCCT TCCAGATCAT CACCTACCGA GACTTTCTGC CCCTGGTTCT GGGCAAGGCC CGGGCCAGGA GAACCCTGGG GCACTACAGG GGGTACTGCT CCAATGTGGA CCCACGGGTG GCCAATGTCT TCACCCTGGC CTTCCGCTTT GGCCACACAA TGCTCCAGCC CTTCATGTTC CGCTTGGACA GTCAGTACCG GGCCTCCGCA CCCAACTCGC ATGTCCCACT TAGCTCTGCC TTCTTTGCCA GCTGGCGGAT CGTGTATGAA GGTGACCAGG TTTTCCAGGG GGCAAATGGG GGTGAGGGTG GGGAGCATGC CCTCCCCTAG GTGG-3' (FRAG.NO:J(SEQ.ID NO:2487)

5'-TCCAGCTGCT TCATGTCTCT CCAGAACTCT GTTTCCTGAC AAACGTTACT AACATACCCG ACTGGCTTGT CCAGCTCTGG GCTAGCTTGG CATCATGTGA TAACCCAAGT AGCTTCCCAG AGGCTGGTCC AATCTGTGCT GCTCACATTC CCTGCCACCA GGGGGCATCG ACCCCATCCT CCGGGGCCTC ATGGCCACCC CTGCCAAGCT GAACCGTCAG GATGCCATGT TAGTGGATGA GCTCCGGGAC CGGCTGTTTC GGCAAGTGAG GAGGATTGGG CTGGACCTGG CAGCTCTCAA CATGCAACGA AGCCGGGACC ACGGCCTTCC AGGTGAGGGG GCTGTCCACC TCTTCTCCCA GCTTTGCTCG GGCCAGGCTG CTCAAGGGGT TCTGGGAAGA CCCTGGTACC-3' (FRAG.NO:_)(SEQ.ID NO:3488)

5'-CGACTGCCTG GTAGGTTCTG GTGGCAGAAA CGAGGTGTTT TCACCAAAAG ACAGCGCAAG GCCCTGAGCA GAATTTCCTT GTCTCGAATT ATATGTGACA ATACCGGTAT CACCACGGTT TCAAGGGACA TCTTCAGAGC CAACATCTAC CCTCGGGGCT TTGTGAACTG CAGCCGTATC CCCAGGTTGA ACCTATCAGC CTGGCGAGGG ACATGAGGCT TCTGCAGGTA AGGGGAGGCC ACCTCCAGCA CCCTGGGCTG GTTAAGCCTC ACATCCTTCC CTGGATGGAT GGCTGAGTCC TCTTAGGTCT CTAAGCAGAG AAAACAGAAC TTGTCACTAG GTACTCTTTC CAAGTGGCTT CCCAATGTGC TAGTTTCTGG GCTGACAGTC AATTCCAGGC CCTAGGACTT TGGGGGGAAA TTAGGAGCAT CCAACTA-3' (FRAG.NO:J(SEQ.ID NO:2489) 5'-GAATTCCGTG GCCAGGACCC CTGCCAGGGC ACTGACCCAG CCTCCCCTGG GGCAGTGGAG ACCTCGGTCC TGCGAGACTG CATAGCAGAG GCCAAGTTGC TGGTGGATGC TGCCTACAAT TGGACCCAGA AGAGCATCAA GCAGCGGCTT CGCAGCGGTT CAGCCAGCCC CATGGACCTC CTGTCCTACT TCAAACAACC GGTAGCAGCC ACCAGGACAG TTGTTCGGGC CGCAGATTAT ATGCATGTGG CTTTGGGGCT GCTTGAAGAG AAGTTACAAC CCCAGCGGTC CGGACCCTTC ATTGTCACTG ATGTGCTAAC AGAACCACAG CTGCGGCTGC TGTCCCAGGC CAGTGGCTGT GCTCTCCGGG ACCAGGCCGA GCGCTGCAGC GACAAGTACC GCACCATCAC TGGACGGTGC AACAACAAGA GGAGACCCTT GCTAGGGGCC TCCAACCAGG CTCTGGCTCG CTGGCTGCCC GCCGAGTATG AGGATGGGCT GTCGCTCCCC TTCGGCTGGA CCCCCAGCAG GAGGCGCAAT GGCTTCCTTC TCCCTCTTGT CCGGGCTGTC TCCAACCAGA TTGTGCGCTT CCCCAATGAG AGACTGACCT CCGACCGTGG CCGAGCCCTC ATGTTCATGC AGTGGGGCCA GTTCATTGAC CATGACCTGG ACTTCTCCCC GGAGTCCCCG GCCAGAGTGG CCTTCACTGC AGGCGTTGAC TGTGAGAGGA CCTGCGCCCA GCTGCCCCCC TGCTTTCCCA TCAAGATCCC ACCCAATGAC CCCCGCATCA AGAACCAGCG TGACTGCATC CCTTTCTTCC GCTCGGCACC CTCATGCCCC CAAAACAAGA ACAGAGTCCG CAACCAGATC AACGCGCTCA CCTCCTTTGT GGACGCCAGC ATGGTGTATG GCAGTGAGGT CTCCCTCTCG CTGCGGCTCC GCAACCGGAC CAACTACCTG GGGCTGCTGG CCATCAACCA GCGCTTTCAA GACAACGGCC GGGCCCTGCT GCCCTTCGAC AACCTGCACG ATGACCCCTG TCTCCTCACC AACCGCTCGG CGCGCATCCC CTGCTTCCTG GCAGGTGACA CCCGATCAAC GGAAACCCCC AAACTGGCAG CCATGCACAC CCTCTTTATG CGAGAGCACA ACCGGCTGGC CACCGAGCTG AGACGCCTGA ATCCCCGGTG GAATGGAGAC AAACTGTACA ATGAGGCTCG GAAGATCATG GGGGCCATGG TCCAGATCAT CACCTACCGA GACTTTCTGC CCCTGGTTCT GGGCAAGGCC CGGGCCAGGA GAACCCTGGG GCACTACAGG GGGTACTGCT CCAATGTGGA CCCACGGGTG GCCAATGTCT TCACCCTGGC CTTCCGCTTT GGCCACACAA TGCTCCAGCC CTTCATGTTC CGCTTGGACA GTCAGTACCG GGCCTCCGCA CCCAACTCGC ATGTCCCACT TAGCTCTGCC TTCTTTGCCA GCTGGCGGAT CGTGTATGAA GGGGGCATCG ACCCCATCCT CCGGGGCCTC ATGGCCACCC CTGCCAAGCT GAACCGTCAG GATGCCATGT TAGTGGATGA GCTCCGGGAC CGGCTGTTTC GGCAAGTGAG GAGGATTGGG CTGGACCTGG CAGCTCTCAA CATGCAACGA AGCCGGGACC ACGGCCTTCC AGGGTACAAT GCTTGGAGGC GCTTCTGTGG GCTCTCCCAG CCCCGGAATT TGGCACAGCT TAGCCGGGTG CTGAAAAACC AGGACTTGGC AAGGAAGTTC CTGAATTTGT ATGGAACACC TGACAACATT GACATCTGGA TTGGGGCCAT CGCTGAGCCT CTTTTGCCGG GGGCTCGAGT GGGGCCTCTT CTGGCTTGTC TGTTCGAGAA CCAGTTCAGA AGAGCCGAGA CGGAGACAGG TTCTGGTGGC AGAACGAGGT GTTTTCACCA AAGACAGCGC AAGGCCCTGA GCAGAATTTC CTTGTCTCGA ATTATATGTG ACAATACCGG TATCACCACG GTTTCAAGGG ACATCTTCAG AGCCAACATC TACCCTCGGG GCTTTGTGAA CTGCAGCCGT ATCCCCAGGT TGAACCTATC AGCCTGGCGA GGGACATGAG GCTTCTGCAG GAGTCTATCC CAAGTCTCCA ACTTTTGGAG ACAAGGGGAA GGGGAGGACC ATGAGGCTGC CTTGTCTCCC TGGAGCAAGT GCAGGCTCGT GACGCTTCTG CTGGCTACAG CTCAGAGCTG GGTTCCCCAG CCAGGAGTGA AGGCTGGGGG CTCCTATCAG CAATGGACCT TCCGCCTTGG GAGCCTCTTA GGTATTAGGC TATGAATCAG CGCCACGTGC AAAGGCTTGG GAGCCAAGCC ATGTGGTCTT GCACCCCAGG CAAGAAAAGT CAGCTGGAGG GTTTACAGCA CTTTCTACTG TTTCCCAGCC CTCCCTCCCC TCCCTCACCA TGACTAAGAG ACCACTCGGT CCTAGCCTCC AGACACCCCA CAATACTCCT CTGAGCCTGA GGCCAGGCAG CATGCTCTGC TTCTACCAAT AAAGCACTGC CGGAATTC-3 ' ( FRAG . NO : _) ( SEQ . ID no : 2490 ) 5'-TC GGC CTG GTC CCG G-3' (FRAG. NO: 1727) (SEQ. ID NO:1738) 5'-TGG GGG TTT CCG TTG-3' (FRAG. NO: 1728) (SEQ. ID NO: 1739) 5'-TG GTC CCG GBG BGC -3' (FRAG. NO: 1729) (SEQ. ID NO: 1740) 5'-GCG CTC GGC CTG GTC CCG G-3' (FRAG. NO:1053) (SEQ. ID NO:1063) 5'-GGG TCT CCT CTT GTT GTT GC-3' (FRAG. NO:1054) (SEQ. ID NO:1064) 5'- TTG CGC CTC CTG CTG GGG GT CC-3' (FRAG. NO:1055) (SEQ. ID NO:1065) 5'-CTC TGT TCT TGT TTT GGG GGC-3' (FRAG. NO:1056) (SEQ. ID NO:1066) 5'-GGG CCC GGC CGT TGT CTT G-3' (FRAG. NO:1057) (SEQ. ID NO:1067) 5'-GTT TGG GGG TTT CCG TTG-3' (FRAG. NO:1058) (SEQ. ID NO:1068) 5'-GGG TTC TCC TGG CCC GGG CCT TGC CC-3' (FRAG. NO:1059)(SEQ. ID NO:1069) 5'-GGC CGT GGT CCC GGC TTC GTT GC-3' (FRAG. NO:1060) (SEQ. ED NO:1070) 5' CCT GTC TCC GTC TCG GCT CTT CTG-3' (FRAG. NO:1061) (SEQ. ED NO:1071) EPI-109 122

5'-GGG CCT TGC GCT GTC TTT GGT G-3' (FRAG. NO:1062) (SEQ. ID NO:1072)

5'-GCB CCG TCC BGT GBT GGT GCG GTB CTT GTC GCT GCB GCG CTC GGC CTG GTC CCG GBG BGC -3' (FRAG. NO:1063) (SEQ. ED NO:1073)

Human Intercellular Adhesion Molecule-1 (ICAM-1) Nucleic Acid and Antisense Oligonucleotide Fragments

5 -GCG CGG GCC GGG GGC TGC TGG G GGT TGG CCC GGG GTG CCC C GCC GCT GGG TGC CCT CGT CCT CTG CGG TC GTG TCT CCT GGC TCT GGT TCC CC GCT GCG CCC GTT GTC CTC TGG GGT GGC CTT C GCT CCC GGG TCT GGT TCT TGT GT TGG GGG TCC CTT TTT GGG CCT GTT GT GGC GTG GCT TGT GTG TTC GGT TTC TGC CCT GTC CTC CGG CGT CCC CGG BGC CTC CCC GGG GCB GGB TGB CTT TTG BGG GGG BCB CBG BTG TCT GGG CBT TGC CBG GTC CTG GGB BCB GBG CCC CGB GCB GGB CCB GGB GTG CGG GCB GCG CGG GCC GGG GGC TGC TGG GBG CCB TBG CGB GGC TGB G-3' (FRAG. NO: 1730) (SEQ. ID NO: 1741)

5'-GGG GGC TGC TGG G-3' (FRAG. NO: 1731) (SEQ. ID NO:1742) 5'-T GTC CTC CGG CGT CCC-3' (FRAG. NO:1732) (SEQ. ID NO:1743) 5'-G CCB TBG CGB GGC TGB G-3' (FRAG. NO: 1733) (SEQ. ID NO: 1744) 5'-CTC TGG GGT GGC CTT C-3' (FRAG. NO:1734) (SEQ. ID NO:1745) 5'-GCG CGG GCC GGG GGC TGC TGG G-3' (FRAG. NO:1064) (SEQ. ID NO:1074) 5'-GGT TGG CCC GGG GTG CCC C-3' (FRAG. NO:1065) (SEQ. ID NO:1075) 5'-GCC GCT GGG TGC CCT CGT CCT CTG CGG TC-3' (FRAG. NO:1066) (SEQ. ID NO:1076) 5'-GTG TCT CCT GGC TCT GGT TCC CC-3' (FRAG. NO:1067) (SEQ. ID NO.1077) 5' GCT GCG CCC GTT GTC CTC TGG GGT GGC CTT C-3' (FRAG. NO:1068) (SEQ. ID NO:1078) 5'-GCT CCC GGG TCT GGT TCT TGT GT-3' (FRAG. NO:1069) (SEQ. ID NO:1079) 5'-TGG GGG TCC CTT TTT GGG CCT GTT GT-3' (FRAG. NO:1070) (SEQ. ID Nθ:1080) 5'-GGC GTG GCT TGT GTG TTC GGT TTC-3' (FRAG. Nθ:1071) (SEQ. ID Nθ:1081) 5'-TGC CCT GTC CTC CGG CGT CCC-3' (FRAG. NO:1072) (SEQ. ID NO:1082)

5 - CGG BGC CTC CCC GGG GCB GGB TGB CTT TTG BGG GGG BCB CBG BTG TCT GGG CBT TGC CBG GTC CTG GGB BCB GBG CCC CGB GCB GGB CCB GGB GTG CGG GCB GCG CGG GCC GGG GGC TGC TGG GBG CCB TBG CGB GGC TGB G-3' (FRAG. NO:1073) (SEQ. ID NO:1083)

Human Vascular Cell Adhesion Molecule 1 (VCAM-1) Nucleic Acid and Oligonucleotide Fragments

5'-CCT CTT TTC TGT TTT TCC C CTC TGC CTT TGT TTG GGT TCG CTT CCT TTC TGC TTC TTC C CTG TGT CTC CTG TCT CCG CTT TTT TCT TC GTC TTT GTT GTT TTC TCT TCC TTG CTG BGC BBG BTB TCT BGB TTC TGG GGT GGT CTC GBT TTT BBBB GCT TGB GBB GCT GCB BBC BTT BTC CBB BGT BTB TTT GBG GCT CCB BGG BTC BCG BCC BTC TTC CCB GGC BTT TTB BGT TGC TGT CGT-3' (FRAG. NO: 1735) (SEQ. ID NO: 1746) 5 -C TGT CGT-3' (FRAG. NO:1736) (SEQ. ID NO:1747) 5'-TGC TTC TTC C-3' (FRAG. NO:1737) (SEQ. ID NO:1748)

HSVCAM1AS1. 5'-CCT CTT TTC TGT TTT TCC C-3' (FRAG. NO:1074) (SEQ. ID NO:1084) HSVCAM1AS2: 5'-CTC TGC CTT TGT TTG GGT TCG-3' (FRAG. NO:1075) (SEQ. ID NO:1085) HSVCAM1AS3. 5'-CTT CCT TTC TGC TTC TTC C-3' (FRAG. NO:1076) (SEQ. ID NO:1086) HSVCAM1AS4 5'-CTG TGT CTC CTG TCT CCG CTT TTT TCT TC-3' (FRAG. NO:1077) (SEQ. ID NO:1087) HSVCAM1AS5 5'-GTC TTT GTT GTT TTC TCT TCC TTG-3' (FRAG. NO:1078) (SEQ. ID NO:1088)

CTG BGC BBG BTB TCT BGB TTC TGG GGT GGT CTC GBT TTT BBBB GCT TGB GBB GCT GCB BBC BTT BTC CBB BGT BTB TTT GBG GCT CCB BGG BTC BCG BCC BTC TTC CCB GGC BTT TTB BGT TGC TGT CGT (FRAG. NO:1079) (SEQ. ID NO:1089) Human Endothelial Leukocyte Adhesion Molecule^ELAM-1) Nucleic Acid and Antisense Oligonucleotide Fragments

5' -BBG TGB GBG CTG BGB GBB BCT GTG BBG CBB TCB TGB CTT CBB GBG TTC TTT TCB CCC GTT CTT GGC TTC TTC TGT C CGT TGG CTT CTC GTT GTC CC TGT GGG CTT CTC GTT GTC CC CCC TTC GGG GGC TGG TGG GGC CGT CCT TGC CTG CTG G GTT CTT GGC TTC TTC TGT CCG T TGG CTT CTC GTT GTC CC TGT GGG CTT CTC GTT GTC CC CCC TTC GGG GGC TGG TGG GGC CGT CCT TGC CTG CTG G CCTGAGACAG AGGCAGCAGT GATACCCACC TGAGAGATCC TGTGTTTGAA CAACTGCTTC CCAAAACGGA AAGTATTTCA AGCCTAAACC TTTGGGTGAA AAGAACTCTT GAAGTCATGA TTGCTTCACA GTTTCTCTCA GCTCTCACTT TGGTGCTTCT CATTAAAGAG AGTGGAGCCT GGTCTTACAA CACCTCCACG GAAGCTATGA CTTATGATGA GGCCAGTGCT TATTGTCAGC AAAGGTACAC ACACCTGGTT GCAATTCAAA ACAAAGAAGA GATTGAGTAC CTAAACTCCA TATTGAGCTA TTCACCAAGT TATTACTGGA TTGGAATCAG AAAAGTCAAC AATGTGTGGG TCTGGGTAGG AACCCAGAAA CCTCTGACAG AAGAAGCCAA GAACTGGGCT CCAGGTGAAC CCAACAATAG GCAAAAAGAT GAGGACTGCG TGGAGATCTA CATCAAGAGA GAAAAAGATG TGGGCATGTG GAATGATGAG AGGTGCAGCA AGAAGAAGCT TGCCCTATGC TACACAGCTG CCTGTACCAA TACATCCTGC AGTGGCCACG GTGAATGTGT AGAGACCATC AATAATTACA CTTGCAAGTG TGACCCTGGC TTCAGTGGAC TCAAGTGTGA GCAAATTGTG AACTGTACAG CCCTGGAATC CCCTGAGCAT GGAAGCCTGG TTTGCAGTCA CCCACTGGGA AACTTCAGCT ACAATTCTTC CTGCTCTATC AGCTGTGATA GGGGTTACCT GCCAAGCAGC ATGGAGACCA TGCAGTGTAT GTCCTCTGGA GAATGGAGTG CTCCTATTCC AGCCTGCAAT GTGGTTGAGT GTGATGCTGT GACAAATCCA GCCAATGGGT TCGTGGAATG TTTCCAAAAC CCTGGAAGCT TCCCATGGAA CACAACCTGT ACATTTGACT GTGAAGAAGG ATTTGAACTA ATGGGAGCCC AGAGCCTTCA GTGTACCTCA TCTGGGAATT GGGACAACGA GAAGCCAACG TGTAAAGCTG TGACATGCAG GGCCGTCCGC CAGCCTCAGA ATGGCTCTGT GAGGTGCAGC CATTCCCCTG CTGGAGAGTT CACCTTCAAA TCATCCTGCA ACTTCACCTG TGAGGAAGGC TTCATGTTGC AGGGACCAGC CCAGGTTGAA TGCACCACTC AAGGGCAGTG GACACAGCAA ATCCCAGTTT GTGAAGCTTT CCAGTGCACA GCCTTGTCCA ACCCCGAGCG AGGCTACATG AATTGTCTTC CTAGTGCTTC TGGCAGTTTC CGTTATGGGT CCAGCTGTGA GTTCTCCTGT GAGCAGGGTT TTGTGTTGAA GGGATCCAAA AGGCTCCAAT GTGGCCCCAC AGGGGAGTGG GACAACGAGA AGCCCACATG TGAAGCTGTG AGATGCGATG CTGTCCACCA GCCCCCGAAG GGTTTGGTGA GGTGTGCTCA TTCCCCTATT GGAGAATTCA CCTACAAGTC CTCTTGTGCC TTCAGCTGTG AGGAGGGATT TGAATTATAT GGATCAACTC AACTTGAGTG CACATCTCAG GGACAATGGA CAGAAGAGGT TCCTTCCTGC CAAGTGGTAA AATGTTCAAG CCTGGCAGTT CCGGGAAAGA TCAACATGAG CTGCAGTGGG GAGCCCGTGT EPI-109 123

TTGGCACTGT GTGCAAGTTC GCCTGTCCTG AAGGATGGAC GCTCAATGGC TCTGCAGCTC GGACATGTGG AGCCACAGGA CACTGGTCTG GCCTGCTACC TACCTGTGAA GCTCCCACTG AGTCCAACAT TCCCTTGGTA GCTGGACTTT CTGCTGCTGG ACTCTCCCTC CTGACATTAG CACCATTTCT CCTCTGGCTT CGGAAATGCT TACGGAAAGC AAAGAAATTT GTTCCTGCCA GCAGCTGCCA AAGCCTTGAA TCAGACGGAA GCTACCAAAA GCCTTCTTAC ATCCTTTAAG TTCAAAAGAA TCAGAAACAG GTGCATCTGG GGAACTAGAG GGATACACTG AAGTTAACAG AGACAGATAA CTCTCCTCGG GTCTCTGGCC CTTCTTGCCT ACTATGCCAG ATGCCTTTAT GGCTGAAACC GCAACACCCA TCACCACTTC AATAGATCAA AGTCCAGCAG GCAAGGACGG CCTTCAACTG AAAAGACTCA GTGTTCCCTT TCCTACTCTC AGGATCAAGA AAGTGTTGGC TAATGAAGGG AAAGGATATT TTCTTCCAAG CAAAGGTGAA GAGACCAAGA CTCTGAAATC TCAGAATTCC TTTTCTAACT CTCCCTTGCT CGCTGTAAAA TCTTGGCACA GAAACACAAT ATTTTGTGGC TTTCTTTCTT TTGCCCTTCA CAGTGTTTCG ACAGCTGATT ACACAGTTGC TGTCATAAGA ATGAATAATA ATTATCCAGA GTTTAGAGGA AAAAAATGAC TAAAAATATT ATAACTTAAA AAAATGACAG ATGTTGAATG CCCACAGGCA AATGCATGGA GGGTTGTTAA TGGTGCAAAT CCTACTGAAT GCTCTGTGCG AGGGTTACTA TGCACAATTT AATCACTTTC ATCCCTATGG GATTCAGTGC TTCTTAAAGA GTTCTTAAGG ATTGTGATAT TTTTACTTGC ATTGAATATA TTATAATCTT CCATACTTCT TCATTCAATA CAAGTGTGGT AGGGACTTAA AAAACTTGTA AATGCTGTCA ACTATGATAT GGTAAAAGTT ACTTATTCTA GATTACCCCC TCATTGTTTA TTAACAAATT ATGTTACATC TGTTTTAAAT TTATTTCAAA AAGGGAAACT ATTGTCCCCT AGCAAGGCAT GATGTTAACC AGAATAAAGT TCTGAGTGTT TTTACTACAG TTGTTTTTTG AAAACATGGT AGAATTGGAG AGTAAAAACT GAATGGAAGG TTTGTATATT GTCAGATATT TTTTCAGAAA TATGTGGTTT CCACGATGAA AAACTTCCAT GAGGCCAAAC GTTTTGAACT AATAAAAGCA TAAATGCAAA CACACAAAGG TATAATTTTA TGAATGTCTT TGTTGGAAAA GAATACAGAA AGATGGATGT GCTTTGCATT CCTACAAAGA TGTTTGTCAG ATGTGATATG TAAACATAAT TCTTGTATAT TATGGAAGAT TTTAAATTCA CAATAGAAAC TCACCATGTA AAAGAGTCAT CTGGTAGATT TTTAACGAAT GAAGATGTCT AATAGTTATT CCCTATTTGT TTTCTTCTGT ATGTTAGGGT GCTCTGGAAG AGAGGAATGC CTGTGTGAGC AAGCATTTAT GTTTATTTAT AAGCAGATTT AACAATTCCA AAGGAATCTC CAGTTTTCAG TTGATCACTG GCAATGAAAA ATTCTCAGTC AGTAATTGCC AAAGCTGCTC TAGCCTTGAG GAGTGTGAGA ATCAAAACTC TCCTACACTT CCATTAACTT AGCATGTGTT GAAAAAAAAA GTTTCAGAGA AGTTCTGGCT GAACACTGGC AACGACAAAG CCAACAGTCA AAACAGAGAT GTGATAAGGA TCAGAACAGC AGAGGTTCTT TTAAAGGGGC AGAAAAACTC TGGGAAATAA GAGAGAACAA CTACTGTGAT CAGGCTATGT ATGGAATACA GTGTTATTTT CTTTGAAATT GTTTAAGTGT TGTAAATATT TATGTAAACT GCATTAGAAA TTAGCTGTGT GAAATACCAG TGTGGTTTGT GTTTGAGTTT TATTGAGAAT TTTAAATTAT AACTTAAAAT ATTTTATAAT TTTTAAAGTA TATATTTATT TAAGCTTATG TCAGACCTAT TTGACATAAC ACTATAAAGG TTGACAATAA ATGTGCTTAT GTTT GATCAAAATT TTTACCTATT ATGCATTTGA TATATAAATA AGTATATAAA TGCACACACA GACACAGCAA TGATGGTGAA CAGTCTTCAT ACAATTATAT GGATGAATCT CATAAAATGC TGAGTTAAAG AAATCAGACC AAAGAACATA TACTGAAAGA TTCTCTCTAT ATACAAAGTT CAAAAATAGG TGGACCAATT CATGGTGGTG TTAGAAATCA GAAGAGAGGC TACCTTTGTG GGGAGGGGAC AGTTTAATGC CCAGAAGCGG TAAATAAGGA ATCCTCTGGG GAGTGGTAAT GATCTGGATG CTGGCTACAG GATGTGTTGG TTGTAAAAAT GCATTTTTTT ATATCTAGCT TTTTCCATGT GTATATTATA CTTCAAAGAA GTTCAGTTAA TAATTTCTCA TGTCACTGTA GAGTAGCTCA GTTAGCCCCA GCAAGCCTCT GGCTTAATCT TGTTTTACCT TAAGCCATCA GTCATTTACA AGTAGGAAAA TTCACAGGGA AAGTTAGAGT ATAAAATCCA GAATGAAGGT TTACTGGGTA AGAGTCTCTC CATTTTCCAA AGCCCGTTTA TTTCTTGATT CCAGTTCTTA AGAAGTCTCA GCATTGTGTC TTTTTCATGT ATCTTACAAG AAGACAGCAT GTGCTTCTAA CACCTGATAC ATTGTATCTA CCAGCACTTG GTAAACAGAA AAGAACCACA TTTTTCTTGT AGGAGAAATT TGGTGCCTAT TTCCTACCAG GCACCAATAA GTGGGACCAA TAGGTGGGAT TAAAGATACA GTAGAAAGTA TTTAAAACTT GCCAGGGGGC AATAGTCTGA AAATAAGTAA ATTGGTGCTA TAGAATGGAA GTTACAGGCT TCTTTCTTTT TTCCCACAAG ATCTGCTCCT TGAGCCCCTA GAGACTTTTC TGTCTGTTAC TGTTTCTTCA TTCCTCATCT GCAGAGCCAG CCCTGAGAAG TGCAGACCAA AGCCAGGGAA GGCTCTGCAA AGATGTACAA ATGGAAGTCA CCTTAATAAC CTCTGACTGC TGCGCATAAT ACATTTCACT CAAAAGAGGG GTTAAACAAT GGAACAGAAT ACAGAGGCCA GAAATAATGC TGAACACTGA CAACCATCTG ATCTTTGACA AAATCCACAA AAACAAGCAA TGGAGAAAGG ACTCCCTATT CCATAATGGT GCTGGGATAA CTGTCTAGCT ATATACAGAA GATTGAACCT GGGCCCCTTC CTTACATCAT ATACAAAAAA TAACTCAAGA TGGAGTAAAG ACTTAAATCT AAAACCAAAC ACTATAAAAA CCCTGGAAGA TAGCCTGGGA AATACCATTC TGGACATAGG ACCTGGCAAA GACTTCATGA CAAGACACCA AAAGCAATAG CAACAAAAAC CAAATTGACT AATGAAACTA ATGAAACTCT TTAGTTGTAC AACAGATAGT TTATCTGTAC AACAAAATAA ACTATCAACA GAGTAAACAA CCTACAGAAT GGAAAAATTT TTTGCAAACT ATGCATCTGA CAAAGGTCTA ATATCCAGAA TCTATAAGGA ATTTAAACAA ATTTACAAGC AAAAAAATGA CCTCATTAAA AAGTGGGCAA AGGACATGAA CAGATGCTTT TCAAAATAAG ACATTCACAC ATCCAACAAC CATATGAAAA GATGTTTAAC ATCACTAATC ATTAGAGGAA TACAAATCAA AAGCATAATA AGATACCATC TAATACCAGT AGGAATGACT ACTATTAAAA AGTCAGACAA TAACAGATGC TGGTGAAGGT TGTGGAGAAA AGGGAATGTT TATGCACTGC TAGTGGGAAT GTAAACTAGT TCAGCCATTG TGGAAGAGAG TGTGGTGATT CCTCAAAGAA TGTAAAACCG AACTGCCTTT CAATCCAGCA ATCCCATTAT TGGATATACA CCAAAAGGAA TAGAAATTGT TTTACCGTAA AGGCGCATGC ATGCATATGT TCATTACAGC ACTATTTACG ATAGCAAAGA CATGGAATCG TCTAAATGCC CATCAGTGGT AGACTAGCTA AAAAAAAAAA AATGTGGTAC ATATACATCA CAGAATAGTA TGCAGCCATA AAAATGAACA AGATCATCAT GTCCTTTGCA GCAACATGGA TGTAGTTGGA GGCCATTATC CTAAGCAAAT TAATGCAGGA ACAGAAAGCC AAATACCACA TGTTCTCATT TATAAGTGAC AGCTAAATAT TGAGTACACA TGGACACAAA GAAGGGAACA ATAGACATGG GACCTACTTG AGAATAGAGG GTGGGAGGAG GGTGAGGATC AAAAAGTACC CATAGGACAC TGTGCTTATT ACCTGGGTGA TGAAATAATT TGCACACCAA ACCCCTGTGA CACACAATTT ACCTATATAG AAAACCTGTG CATGTACCCC TGAACCTAAA AGTTAATGGT GGGGGGGTGG GGTTAAGCTA CTTTGTGGTA TAAATCTGAG CATTCATATT AAAATAAAAT ATTTACCTCA TTAGAGTAAT TAACATTTAT TAAGCAAAGA GCCAAGTACC TTACACACAT GATGTTTAAT CTCACAATGA TCTTTAATCT CATAACAACC GTCCATTGTA TGTACATATG TGGAAATTGA GCCTTGGAGA GATTAAATGC ATGGGGCATG CCATTTGACT AGAAACTGGA AGCATCAGGA TTTAAACTCA GTTCTGAATG GTTTTGTAGG CTTTGTTTTT TCCACATTAT AGCATGGCCT GCCATGAAGA ACAGGTCCTT TCTGGTGTTT GTCTTGTTTG GTTTAAGTGA AGCAAATATT TATTTAAATA TTCAAGATAT GCTGTTAAAT TTTTACTCAA AAATTTGAGT ACAGTATGGA TCTTCTGAAG CCAAATAACT CTTATTCAAT GCTTAGTTGA GAAATTTTAT GGAGTAGTTC TCAATTTTTA TGTAGTTCCA CTGCAAAGGT AAGTCTTATG GAAAGATTCA CTGTAATTTT TTTTCCTCAT TTGGACATCA GCTTTTTCTT TTCCTCAGAC CCGCTGAAAG ATAATTTTTA AAATAAAAAC CTTGTTTTTA TATCAAGTGG GGACATTTTT TCCAAATGAA AACCGTGTAT TCATTTTATA TGATAAAATC AATGTTATTA TTTTTAAAAT TTTGATTTAA AAATCATTAA AAATAAATTT TCAGATATTA CCTGAAATTC TACCATCCAG AGATAATAGT GCTTAAAGAT TTGATATATA GACACACACA CATATATACA TATATATCAT CCTAAACTTC TTTGTATAAA TGTATATAAA GTTTTTAATA AAAACTAGGA GATTAATGCC EPI-109 124

CTTTGAATGA AAATAAATAC AATGTGTATG CTTTAACATC TTGCCTTTAC TTTATAACAT TTATCACAGC AGTCATGAGA TAATGATTTA CATGGTCATT GTTAGTAAGC TAATAGCTAA GTGCATGAAC TCTGGAGCTA GCCTCCCTGG ATTTTAATCC CAGATCTGTC ACTGACCAGC TGAGCAATAC TAGGTAAATT GCTCTTGTTC CTTAGTTTCT TCATCTGTAA AATAGAGATA AAAATAATAT CCACCTCATA GGATTGGTGT GAGCATTAAA TGAGCATACG TATGTAGGCC ACTTAACAAC AATGCCTTCA CATACTGAAC ACAAATATAC GAGCTGTTGT CTTATTGGGC TCATGTTTTT CCTACCACTA AGCCGCATGC ATGCAAGGAC CATGTTGGTT TTGTTCCACA TTGCATCCCC AACCTGGTAT ACAGTGTGCA TTCAATAGTT GTTGACTATT ATTACTAGTG GCATTTAACA AATATCTGTT AAATGAGTGA AGAAATACCC ATTTACTGCA AGTGTGTCTA ATATTGATGG CATAATGGGG GAAACTCAAA CTCTGGAGTC AAACAGGTTT TAAAACCTTA TTCCCTCATC CTCAGTTATT GACGTTTTTT TTTTGGCAGG TGTGTGTGTG GGACAACTTA TTGAACTTTT CTGAATTTCC AGCTTCGCAT ATATAAAATA GAGATAGTGA TTCATTCTTG CAATGTATGG ATTTGAGACA ATTGTGTAAG TTTATCAATA AATAGTAGCT ATTTTTGTAT AAGTATTACA TATAATATCC AGGCCACTGC TTTGCATAAC CCAAAAGGGG CACCATTCAT GCAGAATACA ACATAAATGG TGTCCCTGGA GCAGTGCAGT ATAGGAACCC TGAGGGGACC TACAGTATAC TTTATAGTTC ATAGATTACA AATTATCCCT TTATCAGAGT CTCTCAAGGT TGGATGTATT TGAGGTCCAT AAGAGCAATT TAGGATTAAC AGTAGCTGCA GAAACCATCT GCAGTGATAT TCTCATTTTA AATCCGCGGG AAAGAAGACA GCTATAAACT TGGGACCTGG GTTTAAGCAT TTTAAATGCC AAGTTCACCA TTTTCTAAAA CACAACAAAT ACCCAGTGAG AGAGGGAGAA GGGAAGTAAA TGCCTCTGAA TAAGCAAGTT AATGTCAGTA GTTGTACTGT ATGCATATTG ATGAACAATA GAGGAACCAA TGTCCAATCA GATGAGCAGG ATATTTGGCA ATAACAAGTT GCCTTTGAGG AAAAATGATT TTCTTGGCAA GTTCTTTATC AGCATTACAA AGCTAAAAGC TACGCTTATC ATCACTTATA CTAGCATACC CTGTTGTGCA AATGCTGTCT GTGTTTGCAT CTGCTATTGT TGATGCCTGG TGCATGAATC AGGACTCCAG CCCACAAGTT TTCCCAGAAC TTTCTTATGG CCATCATCTT TAAGTGTCTG GTGAACAGTC ATAGTTTGGT ACACAAAAGG GTCAACCTGG GGGATGGCTA GGGTTTGACT CAGTCGTTAC ATTTCAATAG AGCAGGAAGG GGAAATGGTG GCCTGTAACC TCAGGGAATT TTGCCAGTTG GTCCACCCCA CTCTCTCTCT CCTGCTCTGA GGAAGTGGCA CAGCCTAGAA CAGCACCACA GGTGAGAGAA ATGCAAACCC TAACCAGAGA AGCAGACTCT TTGCCAGTAG TAATAGTTCA GGACCACCAC CAGCTTTTAT TAAAATTTTT AATAACACTC AAGTATTGGC AGAAAGAAAT AATCTTGGGT TAACTATAAC TAGAATATTG ACTCTTCCTC TGTGGAAGAA TCAGCCAATC ACATTTGTTT ACATCAGTTC CCCTGAAGAA GAAAAATACA CTGATGTTGC AGCAAGACAA ATTTAAGCTA GATGTAAATA ACTTCCTTTA GCCTGTAATG CTAGGCTAAT TACATATTGG AACTATTTTT TCAGGGAAGA ATTGTGTAGG GTTTCAGGGA AGAATTCTGA AGAAAATATA GAGCTGAAAT GATCTTGCAG CTCACTGAAA CTGCAGGGTT TAGATCCACA CTGATACTCG TTCTATTATC ACTGTAATGA AGGCTGATGG AATAAGTAAA AATGTTTTGT ATTAGTATGT TTTTACACTT ATTTGCAAGG CATAAATAGG TTAGGTTTTG ATCTTAATTT AATTCTAACA TGTATTGTGC ACAAGCTGTG AGCAGTTTTC AGGAGTTAGG TATCTGGCCA TGACTGATTT TTCAGGAGTT AATCATCTGG TAGAAGGGTC ATACACAATA GGAAGATGTG TGTGACAGGT TGTGATCATT ACTATAATCA CACAGAGAGC TGTAGAATTT TAGGCTGGCA GGGTGGCTCA CGCCTGTAAT CCCAGCACTT TGGGAGGCCA AGGCAGGCGG ATCAAGAGGT CAGGAGATGG AGACCATCCT GGCTAACACG GTGAAACCCC GTCTGTACTA AAAATACAAA AAAAAAAAAA AGCCAGGCGT GGTGGTGGGC GCCTGTAGTC CCAGCTACTT GGGAGGCTGA GGCAGGAGAA TGGCGTGAAC CCGGGAGGTG GAGCTTGCAG TGAGCCGAGA TCGCATCACT GCAATCCAAC CTGGGCGACA GAGGGAGACT CAGTCTCAAA AAAAAAAAAA AAAAAAAGTC ATGTTAGATC CAGAGGGGTA GCAACTGGGG CTGGGCTGTC AGTCAACTCA GTCAACTCAG TCAACTCTGC TCCCCCACAG GAGATGCCAG TGATGCATTT TCATGGCCAA CATTGTCAGT CAGCATCATT GAATTACTCC TGATTATAGA GACACAGCTG CAAACGATTC CCCATTAAAT ATGATGTTTC TTGCAATGTT TGGAAGGTAC TCCTTTTTAG TAAGGGAAAT CCCCTCTTCT GGCTTGCTGA AAGTTTTTTC TTTCCATTTT AAAAATCGTG AATTCCTTTT TGCAATATTG AGGTGGTTAT ATGGTTTCTC TTCTCTAATC TGTTAATATG GTGATTTAAT GGTTAGAAAT TTTCTAATGT AAATTCCACT CATATTGCAG AAATAAACCT AAACTGAGCA TGAGGCTATA TTTTTTATTT GCTTCTATAT TTGGTTGCTA TACAGTATTA TGTTTAAGAT TTGTTCACAT ATATTTGTGA ATGGGATTGG ACTATTTTTC CTTCTTGCCG ATTTTTATCT GGTTTTTAAA TTAAGGATAT TTTAGACTTA TGAAATATTT GGCAAACAAT CCTTGGCAAG TAATTTTTTG GGGAATTTGT TTTGGCTATT TTGAGTATTA CCCAATATAT TTTAATTAAG TTATTCTTAA TGTTTTCTTA ATTAAAAAAA TTACCTACTC TAGAGATATT CTTTATGTAC TCCAGATTTT GTCTATTTAT ACCACTTTTC TTTTTTCCTC GATGAGTGTC ATAGATGTTC ATCTATTTTT TTATCTTCTT TGATCTTCTC TTATTCCTTG TTTCTATTAA CTTCTGAAGT TTATTATTTT CTTTTTTCCA CTTCCTTATG GTTTATTCTT TCAATTTTTC TCTAACTTCT TAAGTTGGGT GTTTAATTTT TAGCTTGCTT TGCTTTTTTA GGATAAGCAT TAAAACTACA AATTTTCCTT GTTATTCTTT TGCTGCACCC CAAATTGTTG ATATTTCTAT TGTCTAATTT CTATTCAATT AGAATACTTT AAAGTTTCTT TTTGGTTTTT AAAAACTAAC TTTTTAAATT GACAAATAAA AATTGTGTAT ATTTATTGTG CACAGCATAT GGCTTTGAAA TATATGTACA TTGTGGAATG GCTAAATTTA GCTTATTAAT GTATGCATTA TCTCACATAC TTATCATTTT TTGTGGTGAG AGCTATGTGA CTTTTGAACT TATGAGTTAT TTAAATATTT TTAAATTATT AAGCATATTG GGATTTTAAG TAATTTACCT TTTTATTATT AACTTATAAC AAGTAGAACA GTTAACCTGT ATGATTCTAC ATCATTGAAA TTTATTGACA TTTGCTTCAT AGTCTATTAT ATGGTCTACT TTTGTTCATG TTACATCTGT AGTAGAATTG GCTAATAGTT GAGTAAAGTA CACATATGTC TATGAAATCA AGTGTAATCC AGAGAAAAAG AGAAATTTAC TGAATATATT GTTCTAGGTG CTATTATATG TTGTCATGTT TAATCCTCAC CACAATTGTA TGAGGCAGCC ATAATTAATT CCACTTTACA CATGAGGAGC CTGAGGGTTA AAAAAAAAGC TAGCTCTACT ATTTGTAAAG AATGAAGCAA AGATACAAAT GAAGGCCCAC ATATCCTATA ACTAGATATT TAAGCATTTT AATTCAAGCT TTAAAACTGC TAAATAAAAT GTGCTCCAAT TTCTATATTG ACAGACATAC CTTCCTAATG AGCTGGGGTT CGAATTTAGA AATCTTTGAT GCTTCAGAGT CCACACTGAA ATGTGGAGGC ACATAGTGAG TTGGTCCCCA GCCTTCAGTC CACCCACCTT CTCTTTACTA AATCACCTTT CACATACATG TATGAACACC CCAGCCTCCA AGTCCAAACC CTAAACAAAA TGGGACACCC TTGTGCATAC ACAGAGACAC AGCCCATCCT CAGGAAAACC TGGAAAAGTC CATACAAGTT CTGGAAGCAA GCTTGGGACG GTTTCAGTAG TGTGGTCTAT AAGGGAGGCC TCAGAAGACA GGTTTTCTTA ATTCTGTGAA CTTCTCCCAC AGTAGAAAGG GTGCTGGAGG AGGGTCAGAG TGAGGACTTC TAAAGCATGG GTCCTGAGTA GGGGCCACTC TTGCCCAAGT CTAAGAAGGG TACTAGAATA GCACACTACT ACTAGATACT AGAACCCAGA TACAAGCACA GGTCTTCTGA AATTAATAAT AATAATAACT ATTACCATTA TTATACCAGT AGCTGTCATT TATTTAGTGC TTATTATTTG CCAGTCACTG TTCTAAATTC TTTACATGTA TTATACAACT GCCATATAAC TGCCATATGA GGGATGTACC CTCATTGTCA CCATTTTACC GATGAGAAAA CTGGCATAAA ACGTTTAAGT AACTTGTCCA AGTTACAGAG CTTAGTGAAG CCACAATGTT GCTCAATTTG CTCTCAAACT TCAAAGGGAT GGGAAGGACA CCTAAGTCAT AGAGTCTTTA AGAATCAGAG CTAGAAGGAA TCTTAGATGT TATCTAGTCA GCCTCCTCCC ATTACAGTCC AAGAGAAGAT GGCCCTGAGT TACTTGTAGC TATTTTTGCA TGTGAATTGC AAGTGAATAT ACATTCTACT GAAGATAAAA GATATTTAAA GATATCGCTG GATATAGGAA CAGTGGTTTT AAATCTCTAG GCTTTAACTT TTCTCAGAAC AAGAAATCCT TTTTGGTTTT AATCTATATG CACATCTGTA TTTTTCTCAA TTATCGGGTA GTAAAATATA ACTTTTCTTC TGTAATATTT TTTAACTTTA ATGAGTGTTC bPI-109 125

CTCATAATAG AAAAGTTTGG AAACCATTGC TATGGGTATA TACTTTCTAA AGGGATAGTA ATTTCTCTAG AATATTCATT TAATGCTCCA GAAGTAATTA GCACAATTGT GCAAGTCTGT GCATCATCAA CTATACATTC TGCCTGTTTA CTCCAAATCC ACATGAAACT GATTATACAG TCAAAGGCGA GCCCAGTGGA GAGGCATTTT TGGAGACTTC CTGGTACATT GAGACAGGGT CGGCCAGTCT GCGTTAGGGT CTTGGTCAAA ACTGCATTTC TGAAACTAAA CTCAGATTGC TTTCTTTTAA GGGGTCAGAA CTGATTCAAA TCTACATTTT TAAAAGCCTT AGATGTGGGG CTTTTCCTAT TCCCAGTCTC CGCTATTGGT CTTTGTGAAT CCACAGGCAA TTTGGCCACA TCCTTGACTC TCTCTTATAT TAAGAATTAA ACAGCTAAGT TCATGCAGAG GAAATATAAC AAAGGAGGGA CTTTCCTACA AGATCTTTGA AAAATGGAAC ATTTGCATAA GTCATATTTA GCCAGAACTG TTGTTTTATA TTTTCCTTTC TGAATACTTT GTTACACCTC CTCCCAGCCA ACCCCCCCCC TCCCTGACCC CAACTAGTCA GAGACCAAAG CCTTCACAAT GGTTTACACT TGAACCTTCC TGGCCCCACC CTCATCATCA CGCCTGAATA ATTACATTCA CTGACTGGTC TCCCCTGCTT CCGTTTATCT CCACTCCTAA ACCCTCTGAC ACCTTAATCT TCCCAGAATA CCATTGTGAT CCTGTTCCAC TCTTGCTCAA GTTTTCCCAG AAACTAGAGT ACAAACTTTA TAAGCTTTAG AGTTGAAAGC CACTCTATCT CTTTTTCATC CCCAGGTCTC TGCCAAGGCA GTATAACCTG TCCAACATCT CTAACTTCAA TACCTTTGTC TTAGATACTA GACTCTCCTC CTGGTTTCTA ATTAAACCTG ATCTAGGATC TAATTTTGCC TCTGAATTCT GTTGCCCTTT GCCAAGTGAT CTCTTCCTCC TCTGAGCCGC AGCATCTCTG AGCTTGCACA CTTAGCATAG CCATAGCACA CACAGCCTTA GCTTGCAGTT CAGGGTGTTT ACCTTCCCTC CCCTTCCAGA TGCTGGATCC CCAGGGATAG GAACTCTGCC CTTATGTGTC CATAGCCCCT GGTAGTATGT CTTGCAGTCG TACATTTTCA GCAAATGTTT AATTGGTTAA TTGAAGACAA CTGTCCCATG CCTTAAGCCT CTCTTTTTGC TAAACATGCC TGTGTCCTTT GTCATTGAAC AACTATTTTG ATCTATTTTC TTCCTGACAT AGGGGTCAGT TCCGAGGATG CTGAAATCAA GAGACATAGC TTATTCTCTC AAAATTGCTT TCAAGAGTGA TTTTGTTGTG AATTGAGAAC TGGCTGCCTA CTTTTGGACT ACCCACTTCA GCAAGAGTGT TTGAAACCAA ATCTATTCTA AGTAATTTTT TATTCCCTTT TCTCTATGGC ATTAGACACA CAGCTCTTTT AAACTACCTT TCGTTATCTA TTAAACAGAC ATTCAGTAAC TCTATAGACA CTGTCTAGCT ATATGAACTT AGACAAACTA ATATCTCTGA GCTTCAGTTT CTTAAAATTT AAAATGAGGA CAATACCATC TATGGCCGGG GATTAAATGC TATGAGGAAT GTAAACCAGA TGTCAGGTAC CATCTCTCTA AAATCCAGAT AAAATGAATT AAAAATACTG GCCGCAAACC CTCTCTAAGA GTTCTCAAAA TTCTCAGAGA GCTTAATTTT CATGCTCACC ATAGCACCGA TTTTCTTCTA AATATTTTGT TTCTACCAAA ATATTTTGTC CCAATTTTGC CTTTTATGGC TATTTCTTCA TATCCACTTT CCCAAACTAA AGAAGCAGCC CCTTCACCTT AAACTCCTCC TTCAAAGCAA CCTAAATACA GGTCTGGGTT TGTATTCCTA GTGGGATGTT ACAGAGGTTA GTGTGATGCA GAGGAGGAGT CATGCTGTTT AAATCCATAC TAGTCCCCAG AGGCCAGGCT GCTTCTGCCA CCCCTACCCC TCCCGCCACA GAGCTCTTCA GCTTCTCACA TTTCTAGTTC TTCTCTCTCT ACTTTCATTA CCTTCTCTCT TTTTTTTTTT CTTCTCATGT GCTCACGGGA GCAGAGAAAA TTAACTCCTC TAAGTTTTCT TAACACAGAG TGCCTTAATT ACATATTACT ATTGTTTGAG TTCCTGCCAA CACTACGTCT GTAGGGTCAC ACCTGCTATA TTAGAGGCTT ATCAAAAAAA GATAGCTTTC TCCTAAAAAG GGATTTGGAT GCCTACTAAG ATAACTGGAT GCCAAGATAA GTTTAACCTA ACAAACTTTA TTATTATTAT TATTATTATT ATTAGAGATA GGTACTTATT CTGTCACCCA GACTGCAGTG CAGGGATGCA ATAATAGCTC ACTGCAGCCT CAAAGTCCTG AGTTCATGCA ATCCTTCTGC TTCAGCTCCC TGAGTAGCTA GGACTACAGG CATATGCTAC TCTGCCCAGC TACTTTTAAA AAAATAATTA GGGATGGGGT CTTGTTGTAT TGCCCAGGCT CGTCTCAAAC TTCTGGTTTC AAGCAATCCT CCTGCCTTTT ACCTCCCTAA TTGTTGGAGT TACAGGCATG AGCCACAGCA CTCAACCAAG ATTTAAAAAC TTTTAAAAGA AATCACATTA CTTACTGTTA TCATCATTAT GGTTACTACC AGTGTTAAAA CAATTGGTAT TGAAAACACC ACTACCAGAT CAAGCTTCAA ACCAAGATGT CAAGTAAATA TTATTGTCAG ACCTCTGAGC CCAAGCCTGC AGGTATACAC CCAGATGGCC TGAAGCAAGT GAAGAATCAC AAAAGAACTG AAAATGGCCG GTTCCTGCCT TAACTGATGA CATTCCACCA TTGTGATTTG TTCCTGCCCC ACCTTGACTG AGGGATTAAC CTTGTGAAAT TCCTTCCCCT GGCTCAGAAG CTCCCCGACT GAGTACCTTG TGACCCCCAC CCCTGCCCAC AAGTGAAAAA CCCCCTTTGA CTGTAATTTT CCACTACCCA CCCAAATCCT ATAAAACAGC CTCACCCCTA TCTCCCTTCG CTGACTCTCT TTTCAGACTC AACCTGCCTG CACCTAGGTG ATTCAAAAGC TTTATTGCTC ACACAAAGCC TGTTTGGTGG TCTCTTCACA CAGACCATGT GACATTTGGT GCCGTAACTC AGATCGGGGA ACCTCCCTTG GGAGATCAGT CCCCTGTCAT CCTGCTCTTT GCTCCATGAG AAAGATCCAC CTATGACCTC TGGTCCTCAG ACCAACCAGC CCAAGGAACA TCTCACCAAT TTTAAATTGG GTAAGTGGCC TCTTTTTACT CTCTTCTCCA GCCTCTCTCA CTATCCCTCA ACATCTTTCT CCTTTCAATC TTGGCACCAC GCTTCAATCT CTCCCTTCCC TTAATTTCAG TTCCTTTCTT TTTCTGGTAG AGACAGAGGA AACGTGTTCT ATCTGTGAAC CCAAAACTCC AGCACTGGTC ATGGACTTGG AAAGACAGTC TTCCCTTGAT GTTTAATCAC TGCAGGGATG CCTGCCTGAT TATTCACCCA CATTTCAGAG CTGTCTGATC ACTGCAGGGA CGCCTGCCTG GATCCTTCAC CTTAGTGGCA AGTACCACTT TGCCTGGGTG GCAAGCACCA CCTCTCCTGG GGGGCAAGCA CCACCTCTCC TGGGGGGCAA GTACCCCCCA ACCCCTTCTC TCCATGTCTC CACCCTCTCT TCTCTGGGCT TGCCTCCTTC ACTATGGGCC ACCTTCCACC CTCCATTCCT CCCTTTTCTC CCTTAGCCTG TGTTCTCAAG AACTTAAAAC CTCTTCAACT CACGTCTGAC CTAAAACCTA AATGCCTTAC TTTCTTCTGC AATACCGCTT GACCCCAATA CAAACTCAAC AATGGTTCCA AATAGCCTGA AAACGGCACT TTCAATTTCT CCATCCCACA AGATCTAAAT AATTCTTGTC GTAAAATGGA CAAATGGTCT GAGGTGCCTG ACATCTGGGC ATTCTTTTAC ACGTCGGTCC CTCCCTAGTC TCTGTTCCCA ATGCAACTCA TCCCAAATCC TCCTTCTTTC CCTCCTGCCT GTCCCCTCAG TCCCAACCCC AAGTGTCGCT GAGTCTTTCC AATCTTCCTT TTCTACTGAC CCATCTGACC TCTCCCCTCT TCCCCAGACT GCTCCTCCTC AGGTCGCTCC CCGCCAGGCT GAATCAGGCT CCAATTCTTC CTCAGCGTCC GCTCCTCCAC CCTATAATCC TTCTATCACC TCCCCTCCTC ACACCTGGTC CAGCTTACAG TTTCATTCTG TGACTAGCCC TCCCCCACCT GCCCAACAAT TTCCTCTTAA AGAGGTGGCT GGAGCTAAAG GCATAGTCAA GGTTAATGCT

CCTTTTTCTT TATCCAACCT CTCCCATCTC AGTTAGTATT AGGCTTTTT TTCATCAAAT ATGAATACCT AGCCCACTCC

ATGGCTCATT TGGCAGCAAC TCCTAGACAT TTTACAGCCT TGGACCCAGA GGGGCCAGAA GGTCATCTTA TTCTCAATAT GCATTTTATT ACCCAATCCA CTCCCAACAT TAGAAAAAGC TCCAAAAGTT AGACTCCGGC CCTCAAACCC CACAACAGGA CTTAATTAAC CTTGCCTTCA AAGCGTACAA TAATAGAGTA GAGGCAGCCA AGTAGCAACA TATTTCTGAG TTGCAATTCC TTGCCTCCAC TGTGAGAGAA ACCCCAGCCA CATCTCCAGT ACACAAGAAC TTCAAAATGC CTAAGCCACA GTGGTCAAGC ATTCCTACAG GACCTCCTCC ATCAGGATCT TGCTTCAAGT GCCAGAAATC TGGCCACTGG GCCAAGGAAT GCCCTCAGCC TGGGATTCCT CCTAAGCCAT GTTCCATCTG TGTGGGACCC CACTGGAAAT CGGACTGTCC AACTTGCCCA GCACCCACTC CCAGAGCCCC TGGAACTCTG GCCCAAGGCT CTCTGACTGA CTCCTTCCCA GATCTTCTTG GCTTAGTGGC TGAAGACTGA TGCTGCCTGA TCGCCTCAGA AGCCTCCTGG ACCATCACAG ATGCTTTTGG TAACTCTTAC AGTGGAGGGT AAGTCCGTCC CCTTCTTAAT CAATGCAGAG GCTACCCACT CCACATTACC TTCTCTTCAA GGTCCTGTTT CCCTTGTCTT CATAAATGTT GTGGGTATTG ATGGCCAGGC TTCTAAACCC CTTAAAACTC CCCAACTCTG GTGCCGATTT AAACAACATT CTTTTATACA CTTCTTTTTA GTTATCCCCA CCTGCCCAGT TCCCTTATTA GGCTGAGACA TTTTAACCAA ATTATTTGCT TCCCTGACTA TTCCTGGACT ACAGCCACAT CTCATTGCTG CCCTTCTTCC CAACCCAAAA GTGGCAACTC CTTTGCCACT TCCTCTCATA EPI-109 126

TCCCCCTACC TTAACCCACA GGTATGGGAC ACCTCTACTC CCTCCCTGGC AACAAATCAC ACCCTCATTA CTATCCCATT AAAACCTAAT CACCCTTACC TGGGTCAACG CCAGTATCCC ATCCCACAAC AGGCTTTAAA GGGATTAAAG CCTGTTATCA CTTGCCTGTT ACAACATGTC CTTTTAAAGC CTGTAAACTC TCCTTACAAT TCCCCCATTT TACCTGTCCA AAAACTGGAC ATGCCTTACA GGTTAGTTCA GGATCTGTGC CTTATCAACC AAATTGTCTT GCCTATCCAC GCCATGGTGC CAAACCCATA TACTCTCCTA TCCTCAATAC CTCCCTCCAA AACCCCTCCA TAACCCTTAT TCTGTTCTGG ATCTCAAAAC ATGCTTTCTT TACTATTCAT TTGCACCCTT CATCCCAGCC TCTCTTCACT TTCACTTGGA CTGACCCTGA CACCCATCAG CCTCAGCAAC TTACCTGGGC TGTACTGCCG CAAGGCTTCA TGGACAGCCC CCATTACCTC AGTCAACCCA AATTTCTTCT TCATCCATTA CCTATCCAGG CATAGTTCTT CATGAAAACA CACGTGCTCT CCCTGCTGAT CATGTCCAGC TAATCTCCCC AACCCCAGGA CTGGCAAATT GACTTTACTC ACATGCCCCA AATCAGGACA CTAAAGTACC TCTTGGTCTG GGTAGACACT TTCACTGGAT AGGTAGATGC CTTTCCCACA GGGCCTAAGA AGGCCACCGT GGTCATTTCT TCCCTTCTGT CAGACATAAT TCCTTGGTTT GGCCTTCCCA CCTCTATACA GTCTGATAAT GGACAAGCCT TTACTAGTCA AAGCACGCAA GCAGTTTCTC AGGCTCTTGG TATTCAGTGA AACCTTCATA CCCCTTACCG TCCTCAATCC TTAGGAAAGG TAGAACTGAT TAATGGTCTT TTAAAAACAC ACCTCACCAA GCTCAGCCTC CAACTTAAAA AGGACTGGAC AGTACTTTTA CCACTTGCCA TTCTCAGAAT TCGGGCCTGT CCTCGAAATG CTACAAGGTA CAGCCCATTT AAGATTCTGT ATGGACGCTC CTTTTTATTA GGCCCCAGTC TCATTCCAGA CACCAGCCCA ACTTGAACTG TGCCCCAAAA ACTTGTCATC CCTACAATCT TCTGTCTAGT CATACTCCTA TTCACCATTC TCAACTACTT GTAAATGCCC TGCCCTTTTT TACAGTGCTG ATTTATACTT TTCCTCCAAA CCATCATAAC TGATATCTCC TGGTTTTACC TCAAACCGCC ACCCTTAAGT CTCTCTTAAA GTGGATAGAA GATCTTCAGT GACAAGGTAC ACTCCAATAC TTTCACCCTA ATAAAGCCCT ATTCTTTACT TTTATATTCA CTCTTATTCT TGTTCCCATT CTTATGCCAC TCTCTACCTC TCCCCAGCTA TCTCCACCAC ACTATCAATC TCACTCACTC TCTCCTAGCC ATTTCTAATC CTTCTTTAAC AAACAATTGC TGGCTTTACA ATTTCTCTTT CCTCCAAAAT CACCGAGTCC TCAATTTACT CACTGCTAAA AAAGGGGACT CTGCATATTT TTAAATGAAG AGTGTTGTTT TTACCTAAAT CAATCTGGCC TGGTATATGA CAACATAAAA AAAACTCAAG GATAGAGCCA AAAACCTTGC CAACCAAGCA AGTAATTATG CTGAACCCCC TTGGGCACTC TAATTAGATG TCCTGGGTTC TCCCGATTCT TAATCCTTTA ATACCTGTTT TTCTCCTTCT CTTATGCAGA CCTTGTGTCT TCCATTTAGT TTCTCAATTC ATACAAAACC GTATCCAGGC CATCACCAAT CATTCTATAC GACAAATGTT TTAAGGGAGG AGACCACCCC TCATATTGTC TTATGCCCAA TTTCTGCCTC CAAAGAAAGA AGTAAAAATG AAAAGGCAGA AATGAAATCC ACAGGCAGAC AGCCTGATGC CACACCCTGG GCCTGGTGGT TAAGATCAAC CCCTGACCTA ATCAGTTATG TTATCTATAG ATTACAGACA TTGTATGGAA AAGCACTGTG AAAATCCCTG TCTTGTTCTG TTCCTCTAAT TACCAGTACA CGCAGCCCCT AGTCATGTAC CCCCTGCTTG CTCCCCCTGC TTGCTCAATC AGTCATGACC CTCTCACGCA GACCCCCTTA GAGTTGTAAG CCCTTAAGAG GAAAAGGAAT TGTTCACTCG GAGAGCTCGG TTTTTGAGAC ATGAGTCTTG CCAATGCTCC CAGCTGAATA AAGCCCTTCC TTCTTTAACT CAGTGTCTGA GGGGTTTTGT CTGTGTCTTG TCCTGCTACA GTTTCATCTA ACAACCCCAT AATATCACCC CTTACCACAA AATCTTCCTT CAGCTTAATC TCTCCCACTC TAGGTTCTCA CGCCACCCCT AATCCTGCTC GAAGCAGCCC TGAGAAACAT CGCCCGTTAT CTCTCCACAC CACCCCCAAA AATTTTCACT GCCCCAACAC TTTACCACTA TTTCGTTTTA TTTTTCTTAT TAATATAAGA AGATAGAAAT GTCAGGCCTC TGAGCCCAAG CCTGCACGTA TACATCCACA TGGCCTGAAG CAAGTGAAGA ATCACAAAAG AAGTGAAAAT GGCTGGTTCC TGCCTTAACT GATGATATTC CACCATTGTG ATTTGTTCCT GCGCCACCTT GACTGAGGGA TTAACCTTGT GAAATTCCTT CCCCTGGCTC AGAAGCTCCC CCACTGAGCA CCTTGTGACC CCCACCCCTA CCCACAAGTG AAAAACCCCC TTTGACTGTA ATTTTCCACT ACCCACCCAA ATCCTATAAA ACAGCCCCAC CCCATCTCCC TTTGCTGACT CTATTTTTGG ACTCAGCCCA CCTGCACCCA GGTGATTCAA AAGCTTCATT GCTCACACAA AGCCTGTTTG GTGGTCTCTT CACACCGACA CGCGTGATAA TTATTATATT ACTTTTAACT AAAACCCTTT CAGAGTCTCG CAGGGAAGGC TGTATATATC TCATAAAATG TTGGGGCCCA CTGGATCAGA CAAGGCCACA AAGGCCAAAG GGAAGTAAAG ATCTCATTAT TTCTCCTAAT AATTTCCCTG TCCTTTGTCA TAAATGGTGG GTAGGCTGTT ATGGTGATGG CAGATTTTCT TTCCATAAAA TGTCCATAAT AGGACATTTG AACAGAAGGG AAAAATCAAA TTGCTGAAGT TGAAAGAGGG CAATGCAAAG AACTTTGGAG AAAGAACTGT ACAGAGAAGT CAACTGGCAG ATGGGAGGAA GTTTAAGGGG AAAAATATAG ATGTCTAAAG AATACATTTA TTCATTTTCC ACAGTGCAAT TTGGACAAGA AGCCTCTTTC TTGCTTCTTT CTATTCTCAT TAAATCATTA GAGCTCAAGC AATCCTTCTG CCTCAGCTTC CCGACTAGCT AGGACTACAG GTATGTGCTA CTATGCCCAG CTAATTTTTT AAAAATTAGA TTTTAATTTG GTGAACTATT TCTGTAGGAA ACTACAATAA TACAGCCCAG GCACATTGAT CTTGGGTGAA CAAATCAGAA GGAATGAATA ATTCTGTGTT CCTGGGACTC TGACAATTTC ATGAACTTGG TACTCTGAGT AAAGCATAGG AGGAGTTATT TCATAAAATG TGGAGCACAA TCATGTGACA AAGATAATGG GATCCCCATT TCATAAATAA ATCTGAAGTT CAGAGAGAGT AACAACTGGC CAGGGTCACA TCACGGAGAC AGAGGCAGGG TTCCCACTGA TGCCTCTGAC TCCCTGTCCC AGGCCCTTCC TCCTCCCGCA AGCAGAAGTG CAGGGGGCAG AGCTGACCCT GTGCAGTGAA AATCTGAGGG CTGAGTTCCT ATTGGAACAC AAGTGAAAGA CTTCCTGGCT TCTAATCTCA GGATAAGGAC TCAGAGCTCC ATCTGTTCCA GCCTTAGGAT AAGAACCAGA ATCTTACACC ATGAAAGCAT GAAAGGTAAG ATTTGAGTGA GGAAAAAAAA AAAAAAAGTC TGTGTTTCAG ATTCAGTTCA CAAAGCAGTT TCATACTTAA GGTACCATCA CAATAACCCT GTGGGGTAAG CAAGGCAAAT TTCATTCTTG TTTTATGGGC ATAGGAAGTA AGTCTCAGGG AGGTTAAGAC CAAGGTTTCT GGAGAATTTT ATATTATGAA TCTTGATTTA TGGGATTACT ATTATGTAAT TCCTAAGATC ATATAGGAAT CCTAGAGCTT GAATATAGAA CTTTATTTTT AAATCTATAT ACATCATAAT TACAAGGAGT AGTGTCCATT TGGGTTCCTT GGCCCTGATG TGTTAGTGGA ATAAACATTT TTGTCAGGGT TGCCATGTGT GTCTGTGCAC GTGTGCACTG TACACCTCCA GGGGATGTAC CCTAAACCAC ATGAATGTGA TTTGCACATC CAAGATTTAC AGTGTACTAT AGGGAGAATC TTTTGCAACA GCTTTTGCTA TAATACAGAA TCTGAGATGT CTTTGAGAAA GAAAAGTGTA ATCATTACCA AAAAATTATT CTCATAATGT GTGCAAATTT GTATGAAATC TATATTGGCC ATGGGACAAG GAGGTATTTC CAGCTAGCTT CTGAAAGGGC TCTATTCTCT CATAAGAATT CAGCTGTTGA CATTAGGTGA TATCTGCCCA GGTCATCAGA TGCCATAGAG AAAGAGGGTT TGCTGAAACT TATATCAGCA GTGCACTGTA TGCTCTTTCT GATTTATTTG AACATTCATT TATTGAGTGT CAAGTAATGC ACTAGATACT CCAGGGATCT GACACAAACT CTGCCCTGAA GGAGCATGTA ATCTCACTGG GGAGAAAACA AAACATATGA TAATTTCAAA ATAACAAACT AGGCAAACTA GTTAACACTT AAAAAGCAGG CTTTATTCAA ATGCAAAATT GCATGTTACA GGGTAACCTT TCAGTAAGAA GCCAGGAAGA GGAGCTCATC ATGGGTTGGA TTAGTAAAGG ACTAGTTATA AAAGAAGTGG TGGGGTTGAG GGAGGCCTGA GATGAAATTT AAAGAATATG TAGAATCTAG GTAAGTGGAT AAAAGGTCTG GGGGCAGGGG AAAGGAGAGC ATTTCATTGT GAATCAAGGA ATTTCTCCAC CTGTTTTAAC TCTTCCATAT GACATCAAAG AGATGTCACT TGCAGCTAGC ATTTCAGTGA TGTTTTCTTA CTAATAATAT CGTGATAAAA GAAACATTGA CTATAAGAAA TAGGAATGGG TCTCATAAAA GGAAACAGCA AAACCCCCAA ACTAAAAAAC AGCGCAGGCT ATTTCTCTCT TCTCTCCTTT TGCTTGGCAC TCATGAGATG CTAGGTGTGG AAGTCAGCCA ACTGAAAAAG AGAGGTGGCT GAAGAAGGTG GGGAGGCTGA AGCCAGTTAA ATAGGATGGT CCAATTCACA GACGGCGAGG CTACAGTGCA AATAGGACTC TTTCAACTTG AGCAGGACCC EPI-109 127

CATTACTTCA CTGGAGTTAG AAAGAAAGGA GAGCGTAGAC TTTTTGAACT TTCTATAAGA GTGTACCTCC ACAGTATACA GAAGACGACG TGAAATTTGA TCTGCAAGAA AACTGAGTCC ATATTCACAT ATGTATCAAA TTTGCACTTC ATTTAGAAGT GTCTGTCATC AAGTACAGCA CTGAATTGAA ACTGAAAACA AGAGTCAAGA AAGAGCAAAG TCAGCCATCT TTATATTCCA CATGAATCCT TTCCCTTTAT GGTCTTATTT GTTTCTCCTC AGAAAAGACA AAAAGCTGAG CTGTATAAAC ACCTGTGGGC TGGGGGTTGA GGGATAAATG AGGGGCGAAA TGGAAGCTGA AGGAACTGTT GGTCAGGTAG AAATCTTCCC AGATGCACTG AAGGAAACAC ACTTCATGTT TGACGTAGGA GGTGCCACCA CACAAAACGT TTCATGGAAG GATTTAAAGG ATCTCATGAT TTTTAGTATT CCAAGAATTT TCTTTCACCA AGGGCGATTT AATATGGGTC ATTCATACTG AAAGAAAAAC AAAAGATAAT AAGAGTTTAA AAATTGCAAA ACTTGGAGTG TTAGTAGTAA AGGTAAATAT TCATT AGAGA TGAGAAGAGG AGCAAGGAAA TGCTTTCAGC TGGAAATCTC AGACAAGAGG CCAGGCTTTA GGAACCTCTG AAGATGAACA AATGTAAGCA AACCCTAGTA GCAGCACTTC TCAGATTTTC ATGTGCTTAC CACTCAGAGA TGGTGTTAAA ATGCAGACTC TGATTCAGTA GGTCTGAGTG GAGCCTGAGA TTCTGCACCC CTAACAAGCT CTTTAGTGAT GCTTATGCCA CTGGCGCACA GACCCCACTT GGAGAAATTT TTGTGGTGCA TACGGTCTTT GTCTCCAGAT CTAATGAGTC TGAAGGACAG TGTAGATTGA TTTTTTAAAT TTATGTTTAT TTTAATTTAA TTTAATTTAA TTTATTTATT TATTTATTTT TGAGATGGAG TCTCACTCTG TTGCCCAGTC CGGAGTGCAG TGGCACGGAG GCAGCTCATG CAACCACGGC CTCCTGGGTT CAAGCGATTC TTCCGCCTCA ACTTCCTGAG TAGCTGGGAA TACAGGCACG TGCCAGCACA CCCAGCTAAT TTTTGTATTT TTAGTAGAGA TGGGGTTTCA CCACATTGGC CAAGCTAATC TCAAACTCCT GACCTCATGA TCCACCTGCC ACGGCCTCCG AAAGTGCTGG GATTACAGGC GTGAGCCACC GAGCCCAGCT GTAGATTGAT TTTGAGCAGT GGAAAGTCAA GGAATTAGAA GGCATGCTTA AATGGAAAGT GAAATTGGAG AAAATTTAAA CTCATGAAAT AGTGGTGGTT ATAAACTCGT GATAAATTAT ATCCTGGGAT ATAATTTAAT GAGATGGTAA CACATTTAGT TTAAAGAAAT AAGTGACACT TTTTTTGTGT GACACAACTG TCTTATTCTT GGAAAGGACA AGGAGAGAAT GAAATATGGT ATGTCTTCAC AGCACCTTTC AAAGGGAGAA CCAGATTCTG AGGAGCTGGT CTCATGATGA ACTGTCAGGG TAAACCACAG TTCAGCAGCT GCAAATGTGC TTGCCAAAAT AGAGACAAAA AAATGTTTCT GAAAACAAAA TTTCACATAT GCCCTCCTCT GAGGTTGGCA TCATATCTTC CTGTGTATCT TGGGTGTAGC TTCTATCCTG CCAGAATTTA GACAGTAGAA ACCAAATGAG GTGATAAACA GAGTCATTTT GCAGAAGAGT CAAAATAACC CAGCAAGAAA TGAAACCACA AATGCCCAAG GAGTCATTCA TTCACCATTC AAAAGCTAAT AGAAATGAAC ACAAACTACT ATGAAAATTC ACCCAAGAAC TTAAAAAAAA AAAAAAAGGC TCATGGTGTT TAGTGTGATA GTATTCATTT TACCTTTGAC TTGTTCTAAA AACACACCAT ACTTCTACCC CACCCTTCCT CAGTGCCGTC ACACAATGGT TTCAGTGTGA AAAAAAAAAC CACGTTACTG GAAAAGGAGG GTGCCTGGGA CTTGCCACTC TAAGCTGGTA GTCAAGGGTC TTGAGTTCTA AAAGCATACG CGTTAAGAGC ATGATTCCTG GATCCAAATG AGTATGGATC TCAGCATTGC CATTTATTGT GACCTCAGGC TATTTTATTT CTCTGTGCCT GTTTCTTTAT CAGTAATGAA GATGTTCATA GACCCTTCTC CCACAGACTT AAAGGCATAT TTCATGATTT AAGACATGTA AACCATTCAT AACAGTATAC AACATGGAAT TAATATTTGA TAAAGGTTTA TGATTATTGT AACTAACTCT GTCACTTGCT CAAGGCCTAT AGAAAACTTA CTTAATTAGT TCAACTACAA AAAGAGTTTG AATGTGATAT CCACCAAGAT CATATTCAGA CCTAGAATTC TGTGATTCTT ATGAATTAAT ACAGCCTTGG TCAATAAATG AGAGCTGGGC AAATAATTCT TCTTTGCTAG GCCTTTCTAG ACCATCTGGT GAAGCATTCA AGACTTATGT TATTGGGGCC AGCCTTCCTT TCCAACTTCA ACTCCACAAC TCCTCAATAA GCCATGGGCT CAAGAAAGTT CTGCTCAGTG GCCCCTGAAA AATGCTTTCA TAGTCTCACT ACCATACCAC TGCTTACACA ATTTCCTTCC TACAGACTGC CTTCCTTTCC TGCTTTTCTC CATATACCTA AATCCTATCT ATTCTTCATA AGCAACCTTC TTTATAACAT TTTCTATAAC CACCAAGCCA AATGACCTTT TCCTTCTTAA ATATAGCACC CATTGGCCAT TACCATGCTC TGCCTTGTAT TTTTCTGATT TTTTTCTTTC TATATTCCTG TCTTAACTCC CCAGCTAGGT AATAATTTTC CTGAAATCAG GGACCAGGCT GACTCCTCTT GCTGTCTCAA GAAAGCTTAG CAGTTTCCAA CACAAAAATG TTCAATAAAC AACTATTAAT TGACTGATTA TAAAAAATCA GTGAACCATT AAACTTAATA TAGCAATTTG CTTAGCATGG TAATTAGCTT TTTGCTAATA TTCTTCCAGC CAGTCTCTCC TCCTGTGCCT CAAGGACATC TTAAAAAAAA AAAATCTAGT TGATCTGCTT CCATCTAGTG GCAATTAAAA CAGGTGGTTC CGGTAGCCAG AAAACAGCTC TGGGTAGATT GTGCCAGAAA ATACTTTCAC TCAGTAGGTG CGAGTTTGAA AGAAATCTTC ACATCTGTGG GTTTCCTGCC ACAGACATAG GGAGACCAGC CCAGAGAAAG AAGCCTTTCC TCACTAGACT CCATTTGCAC TAGTAAAGAG AAGACAGAGT AATTAAAAAG AATAAAAAGA ACCTCCACTG ATCGTACATC CTCATCCAGT TACCCCTGCC CCACTTCTCC TTCACAGCCA AACATTTTAA AAGAGATGAC TGCTTGTTCT GTCTCTACTT TCTCATCCTC AGTAATGCTC AATGCTTGGC CGTCTGACCT CTGTCTTGAT GTCTGCACTG CAAATAGTCT CCCCACTGAC ACCCTTGTTG CATCCAGGGG ATACTTACTG GTTCTCTTGG CAATGTTTGA AACCGTTCCC CTTTCTTTGT TTCCTTGGCA TTCATTACCC CACACTCTTT CTCCTCTTCC TTCTCCCTGC CTGGCAACAT CTTTTCATTT CTCTTTCCCT TAGGTGACTT ATTAGATAAT GATGTTCCTC TGGCTCCCAT ACTCTCTCCC AGGTCCTCTT CCATTCTTAA AGCACTCACA CCCTCCCTGG ATGATAGTAC CCACTCCTGA GATGGCAGTT ACCTCCTGAA ATGTGAGGGA CCCAAATCCA CTTCTCCTGC CATAGCCTCT GTGCTTTGGA TAGGTCCAAT GAGCCACAGT GAATGATGTG CATACACCCA AAGCTCAGTA CAAAACTGAA CCCATGATCT TTACCTCCAA AACCTCTCAT TCTTTTATGT TCCCTTCTCA GAAGTAAACA GGACTACCAT CCGCCAGTTT CCAGGTGAGA AAGATGATAA TTTGATTCTT CTCTCTCACT TTTAGCCAAT TAACAGACAC ATTCAGTTAA TATCACCTCC TCTTATTTCA TGAACCCATT CTTACTACTA GTTCCCTAGA CAGGCGCCAT CGGTTTTAAT CTAATAACTG CAAATGCCTC CAAAACAAGT CTCTTTGAAT CCAGGCTCAC CTGTCTCCCA CACTTGCCAT ACTGCTCTGC AGGGTGACCT TATAAGATGC CAGAGGTAAG GCTACTCACT GTTTAAACCC CTTTAGTGAT ATCCCAAAAG ACCTCAAGAT AAAGCCCATA TCACATGGCT TATACATTAG TTTATGATCT GGCTTCTGGT GCCTCATTTT TCCCCACTTT TTCCTTTGCA TTCTAAGCAA TGGCCCATAC TAAGTTTGTG ATTGGTAGGA TGGTTGCCCA AACCAGCATC CAATCCCTTC AGAAATCATC TCACTTCATT TCTAGCATTT TAAAGGAAGC TCAGTTGTCC AGCTGGGTAC TGAATATGTC ACCAAAGTCC TCCTTTCATA GTTTATTTTA CTTAAACTCT CCTTCCTAAA ATTCCAGAGC AAGTCACTAA ACCCTAGATA CTGAGAAATA TTTTTCCATC TTCATTTCTG CCAGGTGGGC CATCAACTTT CACATGTCTG CATCTCCTCC CACTGTGCTA TTTCTCCAGT AGAAGAAATT TGAGCTTCAA GACCAAACTG AAAAATACTT GCCTCCTTGG GGAAGCTGTA GGTAGAATTC ATGCTCCCTA TCTTTCCCAC ATTTCTGAAG GACAATGCCT GTTAGAGCAA TTGAATGCAA ATAGTCAATT GAATAAGCAT TTATTCATTT CTCAATAAGT GCTTGTTCAA TTGAATATTT CTTAAATAAT ATATTTAAGA ACAAGAAGAA CACACCACAA TGTTTTTAAC CCTCAGAAAA AATTCTGAGG TAATCAGAAA AATCTCCCTT TACATAAACT GCCCTTTTCT AATAGGGATT ACTTGTTCGT TCATTCATTC ATTCAGCTCC ACTAGCACCA AAAAGCACAG CTCTGAAAGG AAGCTAGTAG ATTTATCACC TTATCTGGTC ATTTGGATGA GGACCCCAGG TAAATAAACT ACTATGGGGT TAATGTGTCT AGCTAGAGCA GGAAGTAACT TAAGGAAGTA GAGAATGAAT CAGCAGATGT GGAAACTCCT CGCCACTAAT AAAACTTACC TTCTCTTGGA TTTCTTGCCT GAAAATAGAA AATAGAGAAA AGGCATTAGC AAAAATTAGA CAATTTAAAG TTTTTCAAGT AAGGGAGAAG GAAGACTCCC ACTCTCAAAA CTGTCTTTTG AAGTATATTA GGTATTTGTT AGGTGGACCC TATCTGTGTC AAAGGAGATT TGAGGAACTG GCTTAATAAA CAGTGGTAGA CACTAATACA GAACAGACAT GTTGATGCAG ATGCCTCCTG AGGTTCCATT bPI-109 128

CCATTCTCCG TGCTACTCAA GAAGACAGAA 25441 TTGCTAAATT GCCTGGTGGC AAGACCCAAT ATGTCCATTC AAGTGTTTAT CCCTTCCCAA TCTGCCATCT CATCCTACCT GCAGATTCTT CCCTTGAGGG ACAGCTGCTA ATACTGTAAA ACTATGTGCC ATTACAGCTC ACAGCATCAT CTCTATGAGA ATCCACAAGA GAATTTCACT TTGGTCTTGT TGGTAGGAAT TGTGCAGCCT CATCTGAGTA ACTAATGTGT TTTTATCTTA CAAACACAAG GAATATCACA TGGTTCTCCT TTGACTGGCT GTAAGGAAAC TCAGAGCTAG ATCTGAGACC CTCTCCTACC AAGTATATAA AACTTTGTGA CATACATTTT TGTGCCATAA CTTCAACCTT GGTTCCAAAT GATTTTTGTA CCCTAAGTTT AAATTTGGCT TTCTTTTTTT TTTTTTTGTA CTCAATAAAA CATCAAGCTC ATTTATTATT GCGAAGAGCG AAACAACAAA GCTTCCACAG CGTGGAAGGG GACCCGAGTG GGTTGCCCAA ATTGGCTTCT TTTTCTTACT TTTTAATTAA TTTTAATTTG CTATACTGAA CACATTTTGT ACTGTTCTCA CATTCTTTTT GAAAAAAGCA GAATATAAAT AAGTAGATAA CTTAAAAAAA ACTCTTTGAG CAGAAAGAAT CATTTGGGAG GCAATATATT TCAGTGGCTG TAAAGTGGCA TTCTAGAATC ATCCTACCCA GGTGAAAGCC CTATTTTGCC ACCTGTAGTG TAGTGTGTAT TTGAACAGCT ACTTTCTTTT CTAAACTACA ATTTCTTCAT CTGTTAAAGA GGCATAATAA TTGTATCATC CTCATTGGGT TGATAAAATA AAATATTTCC AAGTATTTAG TTCAGGTCCT AGCACGTAGA CAGTGTTGCA TTACTGTTTT AATCCTTTAA AGTATTAAAG ACTACTATTT GAAATCTTTT CTTCTAAAAT TCAGCCTGCT GATGACCAAG TGCACTTGAG CAGGGGGAAT CAAATCTGAA TTAATTTCAG ATTCTGGTTA GCTTCACATA AATATTTTTT TTAGGGATGA TGAACCTAAC AGCAATAGAT GAGTAAGAAT CTGTTCCTAC TGAGAGAGTT TCATTTTGAA GAAAAAGGAA CTAAGGGGGC ATGTGTTCAG TTTCATGCCC TGGTCTAACC CTGTGTGTTG GTTCTGGTGG GAAATTCTTC CAACCGAGGA AAAAACCAGT TCACAAATCT GAAGACCAGT GATTTTAGAA GATGTATCTG GACTGGAGTC TAATCTCTGA CTCTGGGTCC TGCTGATATG GTATTTTTGA GATTTGGCCT AAAACATCAT TGCCCTGGTT TCCTTATTTA CCAAACAGGG CCAATGGTAG TGACTAATCA GAAAATGATA ATGCCTGGTG CACAAAATGT GTCTAGATGA GCCCATGCAC AAGGACACAT GTTTCTGGAA CTGTTCCTTA TTCCTTTCCT AAAAGAAAGG AGGGAAAGTC TCCATACTAA GACTACTAGG GCAGGGGACA AAGTGCTAGA GTCAGAAGAT TCATCTGAGG ACAGAAGAAT AGGGGTGAAG GCTCTAGTCA CTTCATTGGC TACCATGCTC TAAATAGTTA CCTGTGCCCT TTTTCTAACT ATTAGAACCC AAAAAGCCTA TAAATTCTCT CTCTCTCTCT CTCTCTCTCT GTGTATATAT ATACATATAC ACACACACAT AGACACACAC ACACACCTAA ACACACACAT AGAGATTTAT GACTTTTTAC TTTTATCCTT GTAAATGCCA TTAACTATAT TTTGTCTTAG ATTTAGCCTG GGAATGTAGC CATTATTTCT ACCATTGCCT CCATAGGAAA AATACTCTTC ATGTTTTAAA GGACCAACCT ACAACTAAAA TCTTTGGAAA GCAGAATCAT TTGTAAGTTG GTGAAAATGG AAGATGTTGT TTTATAAATG AAGACTTTTT TTTTTTTTTT TTTTGAGACA GGGCCTCACT CTGTTGTGGA GTGCAGTGGT GCTGTCATGG CTTACTGCAG CCTTGACCTC CTGGGTTCAA GTGATCCTCC CACCTCAGTC TCCTGGGTAG CTGGGACTAC ATGTGCATGC TACCATGCCT GACTAATTTT TTGTATTTTT GTAGAGATGT GGTTTCGCCA TGTTGCCCAG GCTGGTCTTG AACTCGTGGG CTCAAGTAAT CCTCCTGCCT CAGCCTCCAA AAGTGCTGGG ATTAGAGGTG ACAGCCAAGG TGCCTGGCCC ACAGATGAAG ACTATTTAAT GTTATCTTAA AGATACCCTA AGCTTCCTAC CAAGCCAGTG ATCTTTTGGG GCTTCTGTTT TCTTTGTTGG CATAACTGTA ACTAGCCTAA CTGCCCGTTA TCTGTTTCCT GTTTGCCCCA CACTGATTCC CACAGCAGTT TTCAAGTTAT CGGTTTGAGA TCTTGTACAG AAATGACTCC AAGGTAAAAA ATTTAAAAAC AACCCCTCTA ATTTTTTTAC CCTTGCTTAT AAAACAGCCT TAGCCAGCTA ACCCCTCACT ACATGCAAAT GAGTTTGATT CTATTCTTTT GATTCTACAA ACACTTATTA AAAGATTTTA GAATTCGGAA ATAAATAGCT TCCTTATTAA GGTGACTTAC AGCCCCAAAG TCCTTAAAAT TATTTAGACA ATAGCCACCT TATCCCAGGG GGCAGTGTGT AATAACCCAC CCTGTTCTCT ATCCGTCAGT TCTGCCATCA TCGCCCAAGG TAGGAAGAAA GACAGGACAA CCGGGGTCAA GATTTGAAGT CTCAATGGAA AGAATAATCA GTGGTTGGAG AAAACTGTCA TTCTTCTTTT GCCTTAATGC AGTACTTGAT ACTTATACTT AGTACTGTAT AGTACTTAGT ACTGTATAAT ACTATAAGAT AGTGAGATTC AATCAGCACA GAATTTCTAA TAGCAAGGGC AGAGACATTT TAACTGCTCA GTGCTCTCAG GTTATACATA GCTAATGAAG TTCTTGCATA TCAACAATCC CCACCCCCCT CACACACTTT GTCTTTCTGG ATTGGTTAGA AAACTTACCT AGCGCCCACT ATTCTCAAAT TTAAATGAAA GATAAGATCA GAGTGGCACG CAATTAGGGA CTGATAAATA ATATTTTTGT AATTGCCAGT GTAAATGGAC AGGGGGCAAC CTTTACATAC CATATTCAGT GAACAGAATA CGTACTAACT AATTTGATGG AAGGAAAATT AAAATGACAA TCAACTGAGC CCACAGAAAG GCAACACAGA GCAGTTGGTT AGCAATTGTT TCGAGATCAT CCCTGAACTT GAAACAGGTA TATCTTTTTT TTTTTTTTTT TTGAGACAGA GTCTCACTCT GTCACCAGGC TGGAGTGCAA TGGTGCGGTC TCAGCTCACT GCAACCTCCG CCTCCCGGGT TCAAGTGATT CTTCTGTCTC AGCCTCCCGA GTAGCTGGGA TTACAGGTGC CCGCCACCAC GCCTGGCTAA TTTTTGTATT TTTAGTAGAG ACAGGGTTTC ACCATGTTGG CCAGGCTGGT CTTGAACTGC TGAGCTCATG ATCCGCCCGC CTCGGCCTCC CAAAGTGCTG GGATTACAGG CATGAGCCAC CACACCTGGC CAAAACAGGT ATATCTTAAA AGCTGCCCAA TGTCCATGAA TGTTACAGCC TTGAATGGTT CTTCCAGGTG AGTTTGGCCA AATGTGGCAC CATACACCCA AGGCCTGCTG CAGGCTAGTG GGTTGCTCAC ACTTTAAAGC TGAGACACAC TCATGCCTTA AGGTAAAGGG AGTGATAATC TGGGCAGCAG ATGTTAACTT CTCAAGGCAG TCCTCCTTCT CTTTTCCTCT CCAGTGACGG ATGGTTGGAA AGCATATATG GTGCATTTGG TTAGAGCTGT GGCCTTGGTG AATAGATACT TGGGAGAATA CATGGGAATT TCTCCCAGGG TTAATGCAAT GCCCATGTGT TGGGAACCAG GTGACTCTTG AAGAGGTCAG GTATTTGGGA GCAGTGCCTT GAAACCTTAG TGGACATTAG ACCCACTTCC TAGTGGAATT GTAGCATTGA AATCCAAGGC ATGTAGGCTC TTAGAGGACA GAGATAGTGT GTCATTTTTT CAGAATTAAT TAAGAGCAGG CCAGGCGTGG TGGCTCACAC CTGTAATCCA AGCCCTTTGG GAGGCCAAGG CAGGCAGATC ACGAGGTCAG GAGATCGAGA CCACTCTGGC TAACACAGTG AAACCCCGTG TCTACTAAAA ATACAAAAAA TTAGCTGGGC ATGGTGGCAC GCTCCTGTAG TCCCAGCTAC TTGGGAGGCT GAGGTGGGAG AATAGCTTGA ACCCAGAAGG CGGAGGTTGC AGTGAGCTGA AATTGCACCA CTGCACTCTA GCCTGGTGAC AGAGTGAGGC TCTGTCTCAA AAAAAAAAAA GTATTAAAGA ATTACATAAG AGCAAAGAAC CATTAGAATA TCTCACTTAG TTGTTATCAG CCTAGCAAGC TGCCTTGAAG GTAATAGACA TTTTTAAAAG TTTATCAGAT GAAAAGCGAA AATCAGCCAA CCTGTTTTAA TGAAGGTGTG TCCTGGGCTG ATTTACATGT CTCCAGGGAC TGATGGCTCT AGAATGTAAA GCTTGGCATC CTGCTTGTGT TGAATCTATC ACATTTAATT TCCTGTGGGT TTCTTTTTTT TTTCΓTTTTC ACTTTAAAGT TGTGTTCTTT TCATGTGAAG TTAAACTCAC ATACCTTTTT TTAATCTCCT TGCCAGCCAA ATGATAAATG CCAACCCAGA GAATGCAGTA ACCATGACTG CCACTGGAAT GAAGAGGGGG TTATAATCAC CCTCCTTAAT CATTGAGAAA CTTTTGTCCA ATTCTGAAAG AGAAATCAGT AAGGCACATA GCATGAGACC ACCAGCATTA TTTCCTTAGT CTATCTCATG ATATTTGACT TTTTTCCTCC TTACATCTCC CAGTAGTAGC CCATTTGATG CCATTTGACA GATGAGGAAA CTGGCATGGG AAGGCCCCTG ATGAGTCTAC AGCATAGGCA AAGACTGGAC CAGCCTTGCT AGTCTAATGC CTACAGAATC TCAATGCCCA GATTTGTGGT TCATAGAGTT CCTGAAAATG CACCTAAAAA TGTTGGCAAG AATGGTCATC GTTGTATTTA GCTCCATGGA CTTGTTCAAT GACTGGAACT CTGAAACACA GAGAAGAGCT AAAAGCCTAA TACAACTTCA GGAAAAATAA AAGCCAATGA TCTGAACTGG ATAATTCACC AGTCAAAGGA AATCATTAAT GCTTTTACTT TAAAGCAGTT GTGCAAAAAT AAGCACTTGA TTTTTACATG CCAAGGACCT GCACTAATTT CTTTCCAATG CAGTAGTTAC CACTTCCCTC TACTTCCTTC ACGAATAAGT AAAAGGGCAT GTTTAGAGAT ACTCTTGTAA GTGTAAACTA AGTTCATTTG GGAGCCTCTA EPI-109 129

TTTGAAAATA CTGGTATAAA AAAAAATCTG TCTCCTGATA CTAACATTTG AAGGAATCTA CTTTTTTACA TATTGGCAGA GGGTCTGATT CTATCCTTAG TTCTTCCCAT TACTTTGATG AACCTTTTCA AGGTGATTTG ATCCCCACAC CCAAATATAT GATTGAGAGA AGGCTCAAGT TCCCAGGAGC TCCAGACAGA AGGTACCTGT TGGCTTGATG AAGATGAGGA GGAAATGAAC ACTAGCTAGG CCTTAAAGGG AAATGTCTCT GATAGGCCTA ATACACAGTC CTCTGCTAAA GGCCTCCCTG CCTCTCTCTG CTCATCCACT CTACTCCCTG GCCCTGGGCA CGCAGCACAC AGAGATCAGC ATTTCTGACA GCTTCTGTAG ATCCTACCAT TTAAAGACTT TTGTCATCCA TGCAGATAGT CTCAGGAGCA GACACAGGTA GCTATTCTTT CACATGCTAG CTTAACATGC ATTTGCTTTA GCACCTATTG CCAGGCACTG TGTCAGGTGG AGGGTATACA AAGATGAACA AGACATGATT CTTCTCATAT ACAGATAGAT TTTGGAGGCA TTAGCTTAGT GATGATTCAG GAGTATCCAT TATTTGGGGA AGTAGGTGGT CATTAGTGAC CTTTTACAGG CATTTCAATG GGCTAACAGA GATGTTAGAT TGTAGTGGAA TAGAAGAATG GGTAAAAAGT AAATCAGTGA GTTCAGATTT TAGGAGTTAA GATGGCAAGA GGTGAGAACA AAAAAAGGAA ATGATTGTCA TTAAAGGAGG AGGAAAGACC AGCCAAAGAT TTTACAGTGA GTTAAGCATA CAAATTTATT TCTAGGCCAC ATATTCTTAG CAAAACAACA TGTAAATGTT TATGTATGTC TTTCCTCATA TCTGCTCATC CATCAGCTCC ATCGTTAAGA TTTCAGTTTT CCAGGACAAA CTTACTCACT TTGACATATT GGACTAGGAT TTGACCAGAT TCCAGATGAT TCACAAATGG TTTTCTTCTT CCCAATTAAC TCAGTTCCTT CTGAGCAGAT GAAGGTACAT GCAGAGGTAA AGCTGAAGCT GGCCAGGGGA TGGCTACAGT TCATGATCCC CAAATCTGGT GCTGATAGAG GCTCACACTG AATCACTTCA ATGAAAAAGA AAAAAAAAAA AAAGACAAAA CAGTATTTCT GAGTAGAGAC CCTCCCTTGA GCAAAGGATT TTTAGCCAAA GCTGCCTGAC TACATTACTT GTGATATTGC TTCCAGGCTT TATTTTCTTG AGAATGATGG TGGGTGGTGA ATGAGAGATG AAGGCAAGGA AGCATTGAAA GCTGTGGGGA GAGGAGTAGC TACTCCAGGC TGCTGCCCTA GCTAAGGTGA CCCTCCCCTT CTGCTGGAAG TACCATGCCA TATGGCCTCT GCATCAAGGG CTCTTATGGG ATATTCTCAG AGAATCTCTG CCGTTTCATC TGTTCTGATA TCTACCCAAG CATTTTGAAA AACATCCCAA TTCACTGAAG CAAGTCCAAC TTCCGTAAAT TCCAGTAGGT GGGTTGACAG TTTTATAATT TCAATAAGGG ATTTTGATAG CACTTCTAAG AATTAAACTA CTTAAACTAA TGCATCAGGA GCATACTTGT AGAAAAGTTA ACCAAAACTT CGTAAGTTCA GATGACATTG GTTTTCTCCC ATATGGAGAT AAGGTTGGCA GTTAAAAATG AAAAAAAAAA AAAAACCTAC CTTATTTCAA ACTTGAAAAG ATCAAGAGAT TGTGTTTTTG TTTTTCAGTT GTTATTCTCC TAAAAGTTTA TGCATGAGGA AAAGTAAAAG TGATTTTAAG AATAAGCCAA ATAAAACAAC CAAGAAAGAC CTCCACTACC CTGGGAAGGA AACTGGTTGG TATTAAGTAG GACACCACAT AAAACAGGTG TTATTGAGAG GAGAAGAACC AAAATGTAAC TGAGGTTCAA CAAGACATTA TTTATGCAAT GGCAATGAGA AAAATAAAAA ACACAGTATA ACCATGCTGT ATTGCTATAA GTCATGTTAC ACACTGGGAG ATGGCTTCAG GGGTATTTGG TTTTTACTTT TTGTTTGGGA GGTTTTTCAA AAAAATTTAG TTAGAATAAG TCCTTTGAGA AACATCACAG TAGGTTAAAC AAAGTTAGGT TAAATTAGGC TCCTAAGTTT GACTTCTCAG CAAACTTCTA CTGAATGTTC TGACTGTAAG CCCAGGATTG CATGACAAAA CCTCTAGTCT GAAGTTACTC ACCTTGACAG GTTGGTTCTG GAGATGACCA GTTTCCAAAT GGTCCACAGG TGGTTTCTTC AATCCCAGTT AAGTTTGTTC CTTCAGAGCA GCTGAAGGCA CACTGTGAGC TGAAGCTGAA GTTTCCCAAA GGGTGAGTAC AGTCCATGGT ACCCAGCTCT GGGGCCTCCA AAGGCTCACA CTGAATCACT TCAATAGGGA AAGAAACAGT ATGGGGAAGA GTTAAGAGGA ACTGACGCCT GGATTTGAAT CCTAGCCCTG CCACTTGATA ACCATGTGCC TTTAAACAAG GTTACTTGAA CCCTCCAACT TCAGTTTCTT CATCTATATA AGAGGAATAA TGAAATTGTG TTATCTTTAT CAAATTGATA TGGAAACTAA ATGTAATTCA ATTAGCATAA GTCAAGGACC TTAGAACAAA GCCTGACTCA TCAGAAATTC TAAGTAAACA TTAGCTAGTC TTCATATTAT TATCTTCAGC ATTATCTGTA GTGAGAATCC TTAAAGCCAA ATAGGTGTAA CTGGGAATGA CCAGCTTAGT CGGGAAATAA CTATCACATC AGAGCCCCTG AGTCTACTAG AGTATTGGGA GCAAGATGTT CAGAGAAAGA GTGGGTCTCC ATAATAAGCC TTCTTTGCAA GGAGAGAATA TAAAAGTCTA GGAAGCATTT TGACCTCAAT TCTGTCTTCT ATTCTAGCTC AGTTCCAGAA TTTTAACTCT TTTGATTTTG ACAACCCTCT CCAGAAACTG TATCTATTTC CCTGTTCTGA TTGGTGGTAC AATAGGTAAA TTTAAGACTT GGAAATCAAA GTTTTCACAT TTTAGACCCT GCCATGCCAT TTAGTAAACA GTACAACTTT CATGTCTTAT TCCTCATCTG TCAAATTTAA GCCATTATTG CTACCTTGCT CTAGAGACTT CAAGGAAGAA TGGACTCAAG GAATCAGAAG AATTTTTGTA TTTGGAAACT ATATGAGATG AGATTAGGGA GAAACATGGG AACTAAGAGA AAATGTTATC TTTTTTCATT GATTTAAAGA GTATCTATTA TATATCAAGC ATTACTCTGG GGCTTGAAGA GCTTAGATTT CACCCTGTAG GACAAAATGG TAGGTAGAAA TTAATGGGTG GATTGTCATG TATGTGTGAT GTGTTTTAAT TGCTTTTAAT TGATCAGTCT CCCTGTAGTA TGAATAATGT ATTTGAGGGG AGCTAATTTA AAATTGTGGA ACTCATCTAA TAAACTATTG CAAGAATCTA GAAGAAAGAT AATGACGGCA ATGGTAGTAG AGTTGACAAG TGGAAGACAA ATTAGAAAAA CACTAAGTTG TAAAAATTGG TAGAATGTTA CCCTGCATAA ATGTTGGGGG AGTTAAGAGA GTCTCATACC AGGGTGCCCA TGTAAATGGT GATTCCACAT ACTGAGATAA GAAATACGAA GAGAAAAGCT GACTGGGAAC AATTGGTTTT ATAGTCTTTT AAACATCCCA AAGGACATCC TTAGCATATT TGAGTTCAGA GCTGGAGATA GGCTTATCAG TCCAAAGATC ACATAGATTT GTGAGTCCGC AAAAGTCAGT AAGTTTGACC AAAGGATACA TGTAGATTAG AGTCAGAAGA GCAATATACA AAAGACAAAA GCTGAGAAAT TATAGTAGTT TATGGTCCTG GATAAGTGCT CATGAAGGAT CTCAGGAGAA ATGATCACAG GTAGAAAGAA TGAGAAAAGA GTGATATGAG AGAAACCAAG ACAAAGAAAA GTAAAATGTT AAAAATGAGT GAAATAGGCA TACCAATAAT TAAAAATGAG TAAAATAGGC ATACCAATAA CATAAGGGTT AAAAAATAGA GTTCAAAAAT GGGGTGAGGG TAAAGTATTA GGAAGGAGTC ATGGCCCAGG GATCAAGTGA AATGAGTTAG ATCTATAGAT CTATTTCAGT TGGTTGACAT TTAAATGTAT TTTGGTTTTA ATTCTTTATT GTTTACAAAC ATTGCTTTTT TAAAAAATTA AATTGTCCAA TTCAATTCAG GCTCACAAGC AAGTGCCTCA TATATACAGG CATTTTGTGG ATCCCAAAGA TGCAATGATA AATAGGACAC TTACTGATCT CAAGAAGTTT TCAGTACCAG AGGAGACGGA CAAGTGAACA GATGACTTCA ACATAAGTGG GAGAAATGAG GAAGAAATAT GTGGAGCTAT CAGAACTAAG AAAGCTTCCT AGAAGAAACT GTCTTTGAAC AATGTCTTAA AGATGACATG TTTTTTGGCC ATGTGCAAAA TGAGAGAGAA GGCCACCAGC AAAGTCAGTG TGCTACAGAG CACATGTGTT AAGTGTGGAG AACTGCAAGA AGGAAAGGAA CTACTAGAAG GAAAAAGCAA GATACTTTCT GGGTAACTCA GCCTCCTAAT GATAAATGGC ATAGTTTCTT CCAGACCTTA GAGTTCTAAT TAATCTAACA AGCTCATTAG ATCGTGAGCT TCTTGAGAGC GGGAATCTAC CATGCTAATT CCTTATGGTA ACCCTGACAG CTTTTATCCC AACACTCTGC TTCTTGTGGT ACTCAAAAAG ACTTGTTGAG AAGTGAGTCG AAACTTCATG CTGACTTATG AAATCTTTAC GGAAAGGTAA CAATATTGTG AAAGCAGAGC TTTCTGATCA AAACTTCCCA TTTCTCAGAG TGGCTAGTAT CATTTTGTTC CAACCAGCTT CATGATAAGC TATAATGATT CCTGTGACTT TACCTAAGAA GAAGCAAAGA AAGGAAAGAG ACTTACCAAA CTGACACTGG GGCCCATAGT ACCCCACATC ACAGTTGCAG GTGTAATTAT TGATGATTTC TACACATTCT CCATGGCCAC TGCATGACCA GGGCTGGCAA GAAGCTTTAA GGAGGTCAGA AAAAAAATAT TTTAATGTGA TTACATTTTA GTACTCAAAG TCATTTCTTT AGACATAGAT AACCTTTTGT CTGAGATGAT TTAAATAATC AGGAAAGGTT TATTTGTAAA TTCATAGCAT AAAAATCATA TGCTAAAATT TTTACGTATA AAATACACTA AGCATATAGT CATAGGCATT TATTTGCTTT TGGAATGAAA TTACCAATAC TAATATTCTG TAACACTTAT AGGAAACTTA GTGGCATACC TTGAAACTCT TGAAATTACT TGTTTTTAAT GAGTGAGAAG GTTAAATGAT GACCTGACCT CAATCATTTC TGCATGCAAT TATTTCTTGG CAATCCCTTT bPl-109 130

CTTTATAGAA ATCAAAGATT AAAAAGTCCA AATTTGCTAA AACGGTAGAG TCCAATTTAT AAGAGACCAA ATTAACTATG GTTCATTATT AAAACATCAC TTGGAAAATG CTGGCTGTTT TGGAATTGTA GAAGATTTTA CAGAAATATT CATACACCAA AGATAGTGCA ATTTTTATAT AAAATTATAT AAGGTTAGAC CAAGAAGGAA GCACGCAGCA CCACACTCTC TACTTCACAA TGTGAAAACT GAGGTGATGT GAGCCTAAGT TTCCAACTGG CCCCAGCTGT CAGCTTCTCC TCCCCTGCCT TATTATCAAA GGCACTGATT GTCTAGCTCT TCCTCTGTAC TTCCTACGTA GATCTATCAT TTTGATGTAA CTTGATTTAG GGGTATAGCT TTTGTGCACA GGGACAAATC TTACACACCA AAAATTCTTA GGAGTGACAC GATGCAAGAT TATATAGAGG GCTAGATGTA TTTTAGAATG AACCAGAAGC TGTTCTCATC CCCCCACCTT TCCATGGGGT AAATCTGAGT ATTCTCTTAA CCGTGGCCCT TCCTGAGTCT GAGGCAGCAT AGCCGTCTTG TCACTCCCTA CCTGTGTAAC AGAGGGCTGC CTTTAGTTTG TGGCAGGCGT CATCGTTCCA TTTGCCTGCA TCTTTGTTTC TCTTGATATA GATCTCCACG CAGTCCTCCT TGTTCTTCTT GTTGTTGGGC TCACCATCTC CCCAGTTCTC TGCTTCTTCA GTAAGAGATT TGTTGGTTCC CACCCACGTC CATATTCCTC CTATCTTCCG GATTCCTATC CAGTAGTAAG AACGACTGAA AGGCAGAGTC TTCTCCAGAT ACTCAATTTC CGCCTTGTTT TGTATGGCAA CTAAATCTGT GTAATTGTCT CGGCAGAATC TTCTAGCCCT TTGCCAGTTC ATGGGTΠTT CAGAATAATG GTAAGTCCAG CAGTCGGTTC CATGATGTGC CAGGAAATCT GCAAGACATC AGTGTGACCT ATGCAGACTT ACATAATGTT ACAGCTAAAA AGAACCTAGC ACTACTCCAG GCTGAGCTAG ACACTTAGAG ATGAGGAAAC AGAGCCTAAG AGTGTATGTG ACCATCTCAG GATCACAGAA TAGTTGTTTG CAGATTTGAA GTAGAACCTA GACCTTCTGG CTTGAATATA AGATGCTTTT ATCTAAGGTT CTATTTGAAA CAAATTTAGT GGTTTTCTAG GTTTATTTTC TTATTAATTT TTTTCTCAAA ATTATTTCAG GTGAAATTTA ACCAACATAT TTTAGACATT CATATTTCTT TTTCTTTGTA GCTGTTAATG ATTTACAACT AATTACCGTG TAATATCATA TAACTATACA ATTTACGTAT ACTTTTTAAT CCTGGAATCA TTTCTTGAAG GCCAACACAT ATGTACCTAT GGGAGAAGCA TAATAAGGAC AGGAAGAACA GTGACATACT TTTAAGTAAC CTCTTTTACA TAAAAAACAT TTTATTTTAC CATAGGAAGA ACTGCTTCTG GAAAAGCCCA ATATACCACT CAACTCTTAT ATATCTAACT GTATAATTTT TAAAAAGAAC AATTTACAAA GCCAAATGGT ATAGGATTAT GAAATTCATT AGATCATGTT CTATACACAA AGAGACTCAA CTGATGATGT TTAATAAACA TATGGACCCA TCAAATATGA GGGCTTTGAA GATATCTAAT TAAACACATA ATTACACAAT GACTTCATAA TAATATATGG CATTCTAAGC ATGGTATGAT CTACATGAAT CACTATTTAA TACAGTAAAG AAACAGATAT AATTGATGGT AAAGAGCATC ATAAAATAAA CATTTTGAAC AGAGTTTTGA ATGAGCATTC CACTAGAATG CAAGTTCTAA GAGGGAAAAA ACTGTTGTGT CCACTGCTGT ATCCTTAGTG CCTAGCATAA ATTTCACACA TTGTAGGGAC TCAGAAAATA CCTGTTGTAT GAAAAGAGCA CTAAGTTTCT ATGTGACACA GTGCAGACAT GGCATAAGGA ATGTGTGAAC GGGAGAGTTA GCATGTTTGC TTGGCTAGAG CTGAAAATCC AGGCTAGGGA GAAAGAAGAC ATTAGTTTAC TTAGGAAATG AAAAACCAAG TTCAAAGCTA TTGCTGGAGA GTCTTCAAGA ATCAGATATA AAATTTGTCA CAACAATGGG AGAAGGACCA AAAAATGATA AACCCCCGTC CCTTAATAAG CTCGTATTGT AATTGTAGAA ATGACATTAA TGTACACTGA ACTATGAATA AAAAATAGAA AATGAGGTGC TAAATATTTG GTACAGATTG TAAGTACCTT AACAGAGATT TCTTAATTAA CATTATTCCT TTATAATTGA GGGATTTTGT GGGGTTATTG GGATTTGAAC TCTACAGCAT GGGCTATTAT AGGTTAAAAA TAGTGTTCAG GAGTTTCTGG GGAAGAACTA AAGGTAAGAA GAAAAGAGAT GTTTACAGAA GGGATAGAAT TAACAGCTCT GTGAAATAAT TTTCCCTTAG ACTATGTATA ACTAGTGGAT ATTTAAGAAA AATGAATATA AGTAAAATAG ACTTAGCGAT ATATAAATAT CATAACATAC CACAACAGAG CATTGTCCAC CCCCACAACT TGAAGATGTT CCATAAGTCC CTCTGGGTGC TCTGACATTT CCATGGAAAT ATCTGCAAAT GAAATACAAA ATTATATTTA GATGTATACT CTTAAACCAC ACATTTATAG CCTTTGAGGT GGTGCTTACA ACTTTCTTAA TAATCAGAAT AAAACACATA TGTCTACTAA CCCTGTCTGA GGTAACAGGT TTCTCAGACA TAGATGAAAA ATTACTTCAA ATTTACATCA GAACTGATGC ACAGTTTTGT TTTGTTCTAT TTTATTTTTA CGCTTTAGTC TCAAGTTGCT AATCGGTACT GCCCTGAATT TTTTCTATGG TTTGGTAATT TTTATACCTG CTTTTCTGCT GAGCTATTAG ATAAAACTAT TTAATATTTA CTATGTATAT TTTTTAAAGT ATTGTTGCTG CTTAATTAAC TATTGATGCT TATATTTAAT GTTATAGCCT CACTCTTGAT CATAATGGGT CAATGCCTCA AATACCTAAA AAAAAAAAAA ATTAGATAGC CAGACACCAG GAAAGAAAAG TATTTCTTTT TTTAATAAAA AGAAATACCT TTTTGAGCAA CTGAAATGAC AAAGTCACAA ATTTCCTGCA CACCTTAAAA TATACTTAAT GTAAATGACG AGTTAATGGG TGCAGCACAC CAACATGGCA CATGTATACA TGTGTGACAA ACCTGTATGT TGTGCACATG TACCCTAGAA CTTAAAGTAT AATTTTAAAA AAATTCTATC TTCCAAAGCA TATCACTTCT CAGGTAGACA CAGTGTTTAT TGCAAAAGAT CTGATTTCAA TAGTATTTCT TCAAGAGTCT CCCCAGAGAC AAAGTCAAGA AGAGGAAATC AGCATATCTG AGAAGAAAGA TTTCAGGATC ACTTTTTTTG AGGGTCTGAG AAAATGTTTA GTTTCTATAT TATTTAAAAC CAGAATTGAA ATGGGGTGAT TCCTATCCTT GCCACCTGCC TCTACAACCC CAAGAGTTTC TATCTGAGCA TCTAAACGTC TTTTAGGCTG AAAGGCTCAC CATGGCTTTG CTTGGTCCTT CTCTAGTTCT TCTGCAGCCC ATTGAGCCTC TTGACTTAGC ACAAGGGTCT CAGGTCCTTG CCCAAAGGGA GTGTGCTGTG CTGCAGGTAG ACTGCACTGA ATGTCAACAG AAAGCCTTGC TTTCTTTCAT TTCTCTAACC CAGTCTCACA TCCTCCTCCT CCTCCCCTTT TCCCTCCCCT TCCTCCTGCA CTTCTCTTTC CTCTTTCCCC ACCCCTTTCC TAGACTGGCC TCTATTGCCT CCCACTGAGA CAAAAATGAA CTGCTGATCA GAAAGTAATG TGACTAGATT CTCTCTTCCT TCCCTCCTTT CTATCCTTCC TTCCATTCTC CTATGCATCT TTCCTTACCC TCCTCCTCCT TCACTCATTG TTGTTGCTGT TCTTCTTCCT CTTCTTTTTC CTCCTGCTCC TCTTCTTCTA CTTGTTCTTG TTCTTGTTTT TGTTTGGTTC TTGTTCTCCT CTTCCTCCTT CTCTCTCTCC TCCTCCTCCT TCTTTTCCAC CACCCTCCCC TATCTTTTTC ATAAATGCTA AACTAACTCT TGGCTACCTG TGGTAAATGG CCCTTGGAAA TTGCAAATAC TACAAATCAA AACTGCATTT CAGACATATT TATGATGTTT GCAAAACTTC AGTAGAGCTA AGCAGTGGAC TTGACTCGTT TCGGTTCCTT CACCTCCGTC TTTCCTTGCT CACCACCTAG TGGACGTCCT TGTTAGTGGC ACTTCCTGAA GTTAACCCCT GAAGAGAGCC CATGCTCTCT AGCTTTTCAC CGTGTAGGTT TGGGAGCCTA CAAGTACCTT TAATATTCTT GGACTATAAA ATGAGATGGT TTTATAAGAC TGCATGTGAA ATTAGGACCC ATATGATGAA GGACAATAAA AAGGAAGACC CACTGATGTG AGTCAATGAG TCAAATGCAA ATCAGATTTG CATTTTTAGG AAAATAATAA TAACAACAAC AAAAACTCTG AAGCTCAGCG CCCCATATTT ATTATATTGT TTAATCTTTA TAACAGCTCT CTGCTATAGA TATGATTATT ATCCCCATTC TAAAGAGTCT CAAAGAGGTT AAGAAACAAA TTCAAAAACT AGCGAAAGAC AAGAAATAAC TAAGATCAGA GCAGAACCAT AGGAGGTAGA GACACGAAAA AGCCTTCAAA AAATCAATAA ATCCAGGAGC TGCATTTTGA AAAGATTAAC AAAATAGATG GACCACTAGC TAGACTAATA AGAAAGAAGA ATCAATAGAC ACAATAAAAA ATGGTAAAGG GGATATTACC ACTGATCCCG TAGAAATACA AACTACCATC AGAGATTACT ATAAACATCT TTACACAAAT AAACTAGAAA ATCTAGAAGA AATGGATAAA TTCCTGGACA CATACACCCT CCCAAGACTA AACCAGGAAG AAGTCAAATC CCTGAATAGA CTAATAACAA GTTCTGAAAT TAAGGCAGCA ATTAATAGCC TACCAACTAA AAAAAGCCCA GGACCAGATG GATTCACAGC CAAATTCTAC CAGAGGTACA AAGAGGTGCT GGTACCATTC CTTCTGAAAC TATTCCAGAG AATAGAAAAA GAGGAACTCC TCCCTCACTC ATTTTATGAG GCCAGCATCA TCCTGATACT AAAACCTGGC AGAGACACAA CAAAAAAAGA AAATTTCAGG CCAATATCCC TGATGAACAT CATTGCGAAA ATACTCAATA AAATACGGCA AACTGAATCC AGCAGCACAT CAAAAAGCTT ATCAACCACA ATCAAGTTGG CTTCATCCCT GGAATGCAAG GCTGGTTCAA CATACACAAA TCAATAAACA bHl-109 131

GAATCCATTA CGTAAACAGA ACCAATCACA AAAACCACGT GATTATCTCA ATAGATGCAG AAAAGGCCTT GGATAAAATT CAACACCCCT TCATGCTAAA AACTCTCAAT AAACTAGGTA TTGATGGAAC GTATCTCAAA ATAATAAGAG CTATTTATGA CAAACCCACA GCCAATAGCA TACTGAATGG GCAAAAACTG AAAGCGTTCC CTTTAAAAAC TGGCACAAGA CAAGTATGCC TCTCTCACCA CTCCTGTTCA ACATAGTATT GGAAGTTCTG GCCAGGGCAA TCAGGCAAGA GAAAGAAATA AAGTGTATTC AAATAGAAGA GAGGAAGTCA AATTGTGTCT GTTTGCAGAT GACATGATTG TATATTTAGA AAATCCCATT GTCTCAGCCC AAAATCTCCT TAAACTGATC AGCAACTTCA GCAAAGTCTC AGGTTACAAA ATCAATGTGA AAAAATCACA AGAATTCCTA TACAGCAATA ATAGACAAAC AGAGAGCCAA ATCATGAGTG AACTCCCATT CACGATTGCT ACAAAGAGAA TAAAATACCT AGGAATCCAA CTTACAAGGA ATGTGAAGGA CCTATTCAAG GAGAACTACA AACCACTGCT CAAGGAAATA AGAGAGGACA CAAATGAATG GAAAAACATT CCATGCTCAT GGGTAGGAAG AATCAATATC ATGAAAATGA CCATACTGCC CAAGGTAATT TATAGATTCA GTGCTATCCC CATCAAGCTA CTACTGACTT TTTTCACAGA ATTAGAAAAA AACTACTTTA AATTTCATAT GGAACCAAAA AAGAGCTTGT ATAGCCAAGA CAATCCTAAG CAAAAAGAAC AAAGCTGGAG GCATCATGCT ACCTGACTTC AAACTATACT ACAAGGCTAT AGTAACCAAA ACAGCATGGT GCTGGTACAA AAACAGATAT ATGGACCAAC GGAACAGAAC AGAGGCATCA GAAATAACAC CACACATCTA CAACCATCTG ATCTTTGACA AAGCTGACAA AAAGAAGCAA TTGGGAAAGG ATTCCCCATT TAATAAATGA TGTTGGGAAA ACTGGCTAGC CATATGCAGA AAACTGAAAC TGGATCCCTT CCTTACACCT TATATAAAAA TTAACTCAAG ATGGATTAAA GACTTAAATG GAAGACCTAA AACCATAAAA ATTCTAGGAG AAAACCTAGG CAATACCATT CAGGACGTAG GTATGGGCAA AGACTTCATG ACTAAAACAC CAAAAGCAAC AGCAACAAAA GCCAAAATTG ACAAATGGGA TCTAATTAAA CTAAAGAGCT TCTGCACAGT AGAAAAAAAA AAACTATCAT CAAAGTGAAC AGGAAACCTA CAGAATGGGA GAAAATTTTT GCAATCTATT CACCTGACAA AGGGCTAATA TCCAAAATCT ACAAGAAACT TAAACAAATT TACAAGAAAA AACAAACAAC ACCATCAAAA AGTGAGTGAA GGATATGAAC AGATGCTTCT CAAAAGAAGA AGTTTATGCA GTCAACAAAC ATATGAAAAA AAGCTCATCA TCACTGGTCA TTAGAGAAAT GCAAATCAAA ACCACAATGA GATGCCATCT CATGCCAGTT AGAATGGCGA TTATTAAAAA GTCAGGAAAC AACAGATGCT GGAGAGGATG TGGAGAAATA AGAATGCTTT TTACAGTGTT GGTGGAAGTG TAAATTAGTT CAATCATTGT GGAAGACAAT GTGGCGATTT CTCAAGGATC TATAACTAGA AAAACCATTT GACCCAGCAA TCCCATTACT GGGTATATAC CCAAAGGATT ATAAATCATT CTACGATAAA GACACATGCA CACTTATGTT TATTGAGGCA CTATTCACAA CAGCAAAGAG TTGGAACCAA CCCAAATGCC CACCAATGAT AAACTGGATA AAGATGATGT GGCACATATA CATCATGGAA TACTATACAG CCATAAAAAA GGATGAGTTC ATGTCCTTTG CAGGGACATG GATGAAGCTG GAAACCGTCA TTCTCAGCAA ACTAACACTG GAACAGAAAA CCAAACATTA CCCATTCTCA CTCATAAGTG GGAGTTGAAC AATGAGAACA CATGGACACA GGGAGGGGAA CATCACACAC TGGGGCATGT CAGGGGATGT GGGGCTAGGG GAGGAACAGC ATTAGGAGAA ATACCTAATG TAGATGACAG GTTGATGAAT GCAGCAAACC ACCATGGCAC ATGTATACCT ATGTAACAAA CCTGCACGTT CTGCTCATGT ATCCCAGAAA TTAAAGTATA ATTTAAAAAA AGTTTAAAAA AAGAAAGTTG CCTTAGTCAC ATAACTAGTA AGAGACATGG TTGGGAATTT GAACAGAGGC CAATCAGTTC CAAATCCATG CTCTTGATCA TTAAGCTGAA CTTATGGCAG GAACTTGGAA GACATGGTAA AATGGGGAAA AACGTGGAGC CAGGGAGACT TGTGAAAGTG CCAGTGCTCC CACTATACCC TGAAAGAAGT ATCTAGACTT ACTTTTTTCT AAGTCCTCTC CTCTAATTCT CTCAATCTCT CTCTCTCTTT CTCTAAGAGA TGGGAATGCT GCTCTGTCAC TCAGGCTAGA GTGCAGTGGT GCGATCATAG CTCATTGCAC TCAAGGAATC CTAGGGTCTA GTGCCCCTTC TCCCTCAGCC TCCCATGTAG CTAAGACTAC AGGCACATGC CCCAACCCTC GACTAATTTT TTTATTTTTT ATTTTTGTAG AGACAGGATC TCACTATGTT GCTCAGGCTG TAATTCTGTC TTGAAGCTTG TCCAATCAGG CTTTCAGCCA CACCAATTCC CTGAGACTGC TCTCACCAAG GTCCTACACT TCACTAACAC AAACAGCCTA TTCTCCATCC TCATCTTACT TCACCAGGGA GCTCCTGGTT TTCCTCCTAC TTCACTGGCT ATTTCTTCTG TATCATGTGT TGATTCTCCC TCATCTCCCC AACCTCCAAA CCCTTGGAGT ACTCCAGAGA TCACCGCTTT GCTCTTCTGT GTCTAACCTC ACTAACTTGG TGGTCCAATT CACACTCTTG ACTTTGAATA CCATTTAAAT GCGAACGAAT TCTAAATTCT GTACAACCAG AACCATTCTC CTGTAGCCAA ATGCCTACTC AACATCTCCA TCCCCAAACA AATTTAGTTG TTCAATAAGC CTCTCATATT TTACATATCC CAAACTGAAC TTCTGAATTT CTCCTCCAAT CTGTAGGGCT CTTCCCACAG CCTTTCCATC TCAGTGGATT ATAACTCCAT CCTTCCAGTT ACTCAGACCA AAACTTTTGG AGTTAACTGA GACACCTCTC TTTTTTTTCA CAAGTCATAT CCAATGTGTC AACAAATTTT GGTAGTGGAA ATATTGCGGG ATTTTTTAAG AAATCAGAGA GACCGATGGG GTTCAGGAGG ATATTTATTA TTTAGGTGCA CTGGCCAAGT CAGATTAACA TCCAAAGGAC TGAGCCCTGA ACAAAGAGTT AAGTTACCTT TTAAGCATTT TGTGGGGTGG GAGAGAGGGG TATCTGTGCA GGGGGAAGCA TACTACAGAA GTGAGAAATA AAGACAGTTA TTCAATTAAT TGAGACATGC ATTACATCAT TTCTTACTTT TCAAGAAGAA ACATGTTTTG CGACTTGAGT TTATCTGTCT AGTGACCTTG CAGCTGCACA GCTAGAGAAA CAGGGTCTTC ACAATGCCTG GGAAAGGAGG AGAGGTAAGT CTCACTAGCC ACAGAAAAAC AGGCAGTTAA TTTTTAAAGG GCTCCAGCTC TTTCTCTTTC TCAGGGGGAG TTGGGTTTTG TTACATACAA CTGAGTTTCC GCTTACACAT TATTTAATTT CTTTTAATTC CTGTTCCAAA AGAAGCCAGA TACAAAAGGT TACATGTTGT CTGATTCCAT TTATATGAAA CATATAGAAG AGGTAAATCC ATAGAGACAG AAAGTAGATT AGAGGTTCCC AGGGGCTGAG GAAGAAATGG GGACTAACTG CTTATAGGGT ACAGAGTTTT CTTCTGATAA AAATATTTTG GAACTAGATA GACATTTTGT TAGGCCATTC TTGCATTGTT ATAAAGAATT ACCTGAGACT TGGTAATTTA TAAAGAAAAG ATGTTTAATT GGCTTACACT TCTGCAAGCT TTACAGGAAG CATGGTGCCG ATATCTGCTC AGCTTCTGGT AAGGCCTCAG GAAGCTTACA ATCATGGCAG AAGGTGAAAG GGGAGCAGGC ATATCACATA GCAAAAGCAG GAGCAAGAGA GGGATGTGGG GAGGTGACAG TCACTTTTAA ACAGCCAGAT CTTGTGAGAA CTCATTCACT ATCATGAAGA CAGTACCAAG AGGATGGTAC TAAATCATTC ATGAGAAACC CCACCCTCAT GATCAAATCA CCTCCCACCA GGCCCCACCT CCAACACTGG GGATTACAAT TTGACATGAG ATTTGAGTGA GAACACGGAT CCAAACCATA TCAGAGATGG TGGTTATACA ATGCGATAAA CGTCACTGGA TTGTACACTT TAAGATGGTT GTTTTATGTT GTGTGAACTT CACCTCAATA AAAAAAAATA TTTAATGTAC ATTCAGCCAA AAGAAGATTT GGAATAGGAA AGGTCATGGA GATATATTAA CAGCCATTTG ATGGGTGGTA AGGAAAAGAG TGGTTATTAG ACTGTTTTGT GGCCCTCAAA AGGTAGAACT AGATCGAGTT GGTGAGCATT ATAAAACCAT CACAAAACCC TGGAGAGAGG ACCCAGTGCT GAAGAACCGT TTGCCTGCCA TGAGACATGA GGGAAGTACC AGTGAATGCC ATTGAAAGCA GCATCCCTGG GTCCAAGGGA TGGTCAAAGG ACCACTACCC AACCCTTCCC TAGCCTACGC CTCCATTACA GATGACCGCA AGATTTATTT GCTCATTGCT GCCAACCAAG GCTGCACTCA CTGCAGTTGC TATCAGTTTA TCATGGGTAA AAGGAATGTG CAGTAGAGAA CTAACTAACT GCCCACCTAC CTCCACAATC CTATCAGGAC AAATCACCAT GGCTCACATT TCCTTACATT TGGCATGTAA GCCCCTCTTA CTGTCTGTCA TCTATCTCCT ACACAGTTCA CCTAAACTGT TCTCTCCTGA CCCAACCTTG ATTTTCATCC CAAATGCTTC CTTGCCATCT CTGGGATTCC TGTCTTCACC ATCACCAAAC TCCCCTCAAT CTTCCAGTTT CCTGTTCAAA CTTTTCTCCT ACCTCCTTGC TTTGTCATTA GCCCGACTGC CTCCCTAGGA CATCACTTCC CCTGCAGATC TCTCAAGATG ACAATATTTA TTCTCCACAC AGCACATACT TCAGGGTTGG AAGGCAGGGG CAATCTTCTC CTTTATAATG AGTGCCTCTT ATATATGTTT ATTCATCTGC CCTCTTGTAA AACACACACA CACACACACA CAAAGAAGAA ATAAAATAAC TCTGCTTCTT TGAAGCTTGT GACACTGAGA bPl-109 132

TAAACCATCT CACTGTCCTC ATTGTAGTGA CCTCTCAACT CCTCATGCAA GATTGGCTTT GGCACCTAGT TCCTGATCTT CCTTTCCCTG TAAGCACTTC TCATAGTCTT ACGGGACTTC ACCATCCATG GCACAACCAA TACCACAGCC CAGATCCTCA GCTCTCCAAT GACATTTTCC TCCACTAGAC TTGAGCTACC TCCTTCCCTA GGCACAGCCT CAACCTCGAC AACACCTAAG ACTGTACCGT CTCTAAAGTC ACATGTTCAA ACACTTCACT CTTTAACCAC TGTCTCCTAT TCTTGCAAGT GTATTGCTCA AGTATCTCAT TGCAATGCTT TTTACTTCTA CCTCATTGAA CCTCCAGGCC ATTAAACATT TCCTTATTTC TAACCATCAG GTTTCTCCTT ACTTCTTTGT TTGTTTATTT GTTTCTTTTT TTTTTTTTTT TTTGAGACAG GGTCTCACTC TGTTGCCCAG GCTGGAGTGC AGTGGTATGA TCTCGGCTCA CTGCAGCCTC CATCTCCCTG GTTCAAGTGA TTCTCATGTC TCAGCCTCCC GAGTAGCTGG GACTACAGGT GCATGCCACT ACGCCTGGCT AAGATTTTGT ATTTTTATTA GAGAAGGGGT TTTGCCATGT TGGCCAAGCT GGTCTCGAAC TCCTAACCTC AGGTGATCCA CCTGCCTCAG CCTCCCAAAG TGCTGAGATT ATAGGCATGA GCCACTATGC CCCACCTGGT TTCTCCTTAT TTATTTCAAG TCTATGCTGC ACTATTAAAA CTGCCTTGAC AAAAATTATA ATAGTGAGAA AATTATGACA GTGAAAGAGA TCTGAAATAA TCAACCCCCA TCTTGCCTTT ACCTTCCAGA CTGCCCTTAA TAATTCCTGA GCTTGGGCCA AGCTATCTTT GGCAGAAATT TAGTTTATAG TTTAAATGAT AATAGCCCTT CTCCAAAACT AAACTGCCTT TGTAAAACTA ATAAAAGACC ACCAATGAAA GGTTAGGAGG ATGAGAGGAG CCTGAATTCT GCTAAGGTGT AGATGTAAAC AATTACCAAC TGTTATTCCG GAGGTCACAA GATTTGCAAC ATCGCCAATT ACTCCTGCAG ATAACAGCAC TATCATAGAA TCTGATTGGC CTTTTGAGAT GTCTTTTCAG ATTCTTACAT TTCAACTGGT GGCTCTACCT GGACCCATCA ACAAGTCCTG TGGCTCCACC CAGAAGCAGA CTTAACATGC ACAAGGACCA TTTTCCACAC CGCTATGATT GCATCCCAAC CAATCAGCAG CAACCATTCC TCTGCCTGCC AAATTATCCT TGAAAAATCT TAGCCTTAGA ATTTTGGGGG AGGCTGATTT CAGTAATAAC AAAACCCCGG TCTCCCATTT GGCTGGCTCT GCATGAATTA AATTCTTTCT CTATTGCAGT TCCCATCTTG ATAAATCACC TTTATCTGGG CAGCAAACAA AAGGAACCCA TTGGACAGTT ACACTGTTGG CAGATATATC TTGCTTCCAA AATTGGATTT TTGTTTAATG AATTTATTCT GTTTTCTTGA TATTTACAAC TGTGAATGTT GTGTCTGAAT TCTCTTTATT TCTTGTTGAA AAGAACTATA TTGCTACAGC CAGTACATAC AGATGGATAG CTAATTACTC AACACGGGGG GATGTGACCA TCACCGCACT GTGCAAATGA ATGTTACCCA TTGTCCACTT TTCCCAAACT ACATAGTGTT ATATGGTATA TGACCCAATC AACGGTGGCA AAGCTCCAGA AATACCACAT AGACATCAGG GACACTTTAA ACTAATCAGC CTATAGTCCT TTTTCAGTAA TTTCCAAACC TGGTTGTGCA TCCAAATCAC TTGGTAACAT TAAAAAAACA AAAAAATATA CACGCAACAT TCGCTCCCAA TCCTACTGAA TCAGAATATT TTGGGTTGGT TCAGGAACAT TCAGGAGTTT TTCAGGGTCC AAGGTTTATA TAATTTGAGG TCTCTCTTTG AGAAAAGGAA CGTAAAAGCG TCTTGCTTTT ATAGATCTTA CAAAGATGTA TTACCATGTA AACACATTCC TAGGACCCAG GCCCTTGTAA TTTAAAGGTT TATCTAAGTA ATGGGCCCTG AAGCTTAATT TTCATTATCT TCAGGGCAAA TTACCTGTGG GTTAGGGTTT AGGAATATAT CTCTCTGTGT ATGTGTGTGC ACATTAGCAT GTACGCTTGT GTGGATTTTT TΠTΠTΠT TTTTTTTTTC TGAGACAGAG TCTCGCTCTG TCGCCAGGCT GGAGTGCAGT GGCGTGATCT CTGCTCACTG CAAACTCCGC CTCCCAGGCT CAAGCGATTC TTCTGCCTCA GCCTCTTGAG TAGCTGGGAC TATAGGCACG CACCACTATG CCCAGCTAAT TTTTGTATTT TTAGTAGAGT TGGGGTTTCG CCATGTTGGC CAGGATGGTC TTGATCTCTT GACCTCGTGA TCCACCCGCC TCCACCTCCC AAAGTGCTGG GATTACAGGC GTGAGTCACC ATGCCCAGCA CTTGTGTGGA TGTTTTAAGC TCCCAGGTGA GTGAATACAA AACTAGATCT TTCCCTTCTG TAGCATCTGT ACTGTTTACT CTATGCATCT CAATATTTTT TCTTTTAGTA TCTTTCCTTT TTCTCTCTTA TTACTTCCTC TTGTGCTATT TTTACACCTC CTTTTTTAAA AAATTTTTTC CCTTTTATTT CTATTGACCT TTAGCCCTCA CAATGATTCC TACAAGCCCC ATTTCTGTAA ATGGGGATTG AAATAATTGC TGGACTTTTG AGAGATAGAT ATATTAAATT GCAAACTGGC AGTAGTGGGG GCAGTTGATA CATAACTAGG TTTTAAAGTC TAGCCTTCTG AGACCACTCA TTCCATTTGT GAAAAGTGAT TCTACTTCTT ATTATGAGCC AAAATATGCA TTCATTCACC CATGCATTGA TTTATTCATT CAATAAATAT TTGTTGGATG TCCACTCTGT ATCAGGAATG TGCTAGGTTC TGGGAATACA GCAATGAACA AGGTAATTTT TCCCTACCCC TAAGGAACTT AGAGTTTAGT GGGGAAGACA GACATTAAAC AAACAATTGT GCAAGTAATA ATCTATAATT ATTTATTACA ATTAAAGGAA GGAAGAGACA TATGGATTAT GAGGGCATTA AAGAGGAGAC CTAGTGTAAG TAGCCAGTTC TCGTGAAGGG ACATGTATTA GTTGGAGTTC TCCAGAGAAA CAGAACCAAT GGTGTGTGTG TGTGTGTGTG CGTGTGTGCG TGTGTGTGTT GGGGTGTGGG GGTGTGGTAT TTTTTATAGA AATTGTCTCA CACAATTATG GAAGCTGAGA AGTCCCATGG CCTGCTGTCT ACGAGCTGAG AACCAGGAAA GCCAGTGGAA TACTTCAAAG TCCAAAGGCC CTGGAACCAA GAGTGCCAGT GTTGGAAGGC AGGAGAAGAT GGGTGTCCCA GCTTAAAAAG ACAGTGAATT CACTCTTTTT GCTCTACATA GGGCCTCAAT GGGTTGGATC ATGGCCACCC ACATTGGTGA AGGCAATCCT CTTAGTCTAC CAATTAAATA CTAATCTCTT TGGAAATACT CTCACAGACA CACTGAGAAA TAATGTTTTA TCAGGGTGAT AGAAATCTTC TGGAGTTAAA CAATGGTGAT AGCTGTACAA TCACATACAT TTTTAAAGGG TGCGTTTTAT GGAAAGTGAG TTTTATCTAA ATAAAATTTC TAAGAAAGAG ACTTAACACA GAGATAAACA TAAGCACATT TATTGTCAAC CTTTATAGTG TTATGTCAAA TAGGTCTGAC ATAAGCTTAA ATAAATATAT ACTTTAAAAA TTATAAAATA TTTTAAGTTA TAATTTAAAA TTCTCAATAA AACTCAAACA CAAACCACAC TGGTATTTCA CACAGCTAAT TTCTAATGCA GTTTACATAA ATATTTACAA CACTTAAACA ATTTCAAAGA AAATAACACT GTATTCCATA CATAGCCTGA TCACAGTAGT TGTTCTCTCT TATTTCCCAG AGTTTTTCTG CCCCTTTAAA AGAACCTCTG CTGTTCTGAT CCTTATCACA TCTCTGTTTT GACTGTTGGC TTTGTTGTTG CCAGTGTTCA GCCAGAACTT CTCTGAAACT TTTTTTTCAA CACATGCTAA GTTAATGGAA GTGTAGGAGA GTTTTGATTC TCACACTCCT CAAGGCTAGA GCAGCTTTGG CAATTACTGA CTGAGAATTT TTCATTGCCA GTGATCAACT GAAAACTGGA GATTCCTTTG GAATTGTTAA ATCTGCTTAT AAATAAACAT AAATGCTTGC TCACACAGGC ATTCCTCTCT TCCAGAGCAC CCTAACATAC AGAAGAAAAC AAATAGGGAA TAACTATTAG ACATCTTCAT TCGTTAAAAA TCTACCAGAT GACTCTTTTA CATGGTGAGT TTCTATTGTG AATTTAAAAT CTTCCATAAT ATACAAGAAT TATGTTTACA TATCATATCT GACAAACATC TTTGTAGGAA TGCAAAGCAC ATCCATCTTT CTGTATTCTT TTCCAACAAA GACATTCATA AAATTATACC TTTGTGTGTT TGCATTTATG CTTTTATTAG TTCAAAACGT TTGGCCTCAT GGAAGTTTTT CATCGTGGAA ACCACATATT TCTGAAAAAA TATCTGACAA TATACAAACC TTCCATTCAG TΠTTACTCT CCAATTCTAC CATGTTTTCA AAAAACAACT GTAGTAAAAA CACTCAGAAC TTTATTCTGG

TTAACATCAT GCCTTGCTAG GGGACAATAG TTTCCCTTTT TGAAATAAAT TTAAAACAGA TGTAACATAA TTTGTTAATA AACAATGAGG GGGTAATCTA GAATAAGTAA CTTTTACCAT ATCATAGTTG ACAGCATTTA CAAGTTTTTT AAGTCCCTAC CACACTTGTA TTGAATGAAG AAGTATGGAA GATTATAATA TATTCAATGC AAGTAAAAAT ATCACAATCC TTAAGAACTC TTTAAGAAGC ACTGAATCCC ATAGGGATGA AAGTGATTAA ATTGTGCATA GTAACCCTCG CACAGAGCAT TCAGTAGGAT TTGCACCATT AACAACCCTC CATGCATTTG CCTGTGGGCA TTCAACATCT GTCATTTTTT TAAGTTATAA TATTTTTAGT CATTTTTTTC CTCTAAACTC TGGATAATTA TTATTCATTC TTATGACAGC AACTGTGTAA TCAGCTGTCG AAACACTGTG AAGGGCAAAA GAAAGAAAGC CACAAAATAT TGTGTTTCTG TGCCAAGATT TTACAGCGAG CAAGGGAGAG TTAGAAAAGG AATTCTGAGA TTTCAGAGTC TTGGTCTCTT CACCTTTGCT TGGAAGAAAA TATCCTTTCC CTTCATTAGC CAACACTTTC TTGATCCTGA GAGTAGGAAA GGGAACACTG AGTCTTTTCA GTTGAAGGCC GTCCTTGCCT GCTGGACTTT GATCTATTGA EPI-109 133

AGTGGTGATG GGTGTTGCGG TTTCAGCCAT AAAGGCATCT GGCATAGTAG GCAAGAAGGG CCAGAGACCC GAGGAGAGTT ATCTGTCTCT GTTAACTTCA GTGTATCCCT CTAGTTCCCC AGATGCACCT GTTTCTGTAA ATATAAACAT GCATGTCATC AGAACACTTA ATATTCTGCA TACTGATCAT GACAACAAAA TGTACCTTCT AACACAGACA CTCTCACTAG GATAGACCAT GTAGGAACAT CGAATTCTAT TCAGTTAGGA CAGTGATGAT GTCTACATAT TATACCTCTG TCAAAACCTA CAGAATATAC AACACAGCAC AGAGTGAATT CTAATGTAGC CTGTGGACAT TAATGAATAA TAATGTATCA ATATTGGCCC ATCAGTTGTA ACACTAATAT AAGATGTTAA TAACAGGGGG AATTGAAGGG GTGGTGGGGA GATATGTTGG AACTCTTTGT GCTTTCTGCT CAATTTTTCT GTAAACTTAA AACCGCACAC ACAAAAAAAG TTATTTTAAT TTTTTAAAAA GTATTCAGAG GGACTTGACC TTTCCAAATT CTCTCAAAGC AGGTCGGAGT AGTTAAGAAC ACAAATTTTA GAACCAGACT GCCAGAGTTT GAATCCTGGC TACACCACTT ACTAGCTTTG AGATTTCAGA CAATTTACTT AACTTCTCTG TCTCATTTTC TTCATCTGTG TGATAAGAAA TAAAGTAACA GGCCAGGCCC AGTGGCTCAC GCCTGTAATC CCAGCACTTT GAGAGGCCAA GGCGGGTGGA TCAGGAGTTC AAGATCAGCC TGGCCAACAT GACGAAAAAA TACAAAATCT CTACTAAAAA TACAAAAATT AGCTGGGTGT GGTGGCAGGC ACCTGTAATC CCAGCTACTC AGGAGGCTGA GGCAGGAGAA TTGCTTGAAC GCAGGAGGTG GAGGTTGCAG TGAGCCAAGA TCATGCCACT GCACTCCAGT CTAGGCAACA GAATGAGACT CCATCTCAAA ATTAAAAAAA AAAAAAGTAA AAAGAAAAGA TAAGAAATAT AGTACCAGCC CCTATCTCAG AGTTCCTAGC TTAGAAAAAT TCCCAGAATA TAATAAGTGC AATGTAAGGG TCAGCTATCT TCATTATTAT TATCTATCAT AAATGAAATT ACACAATAAA GCTAGATCCG TTTCTTTCCT CTCCTTCTAC AAAAAATAAA GCAACTTTCC AGAACAATAC CCAGGTGATG ATTTCTCCCC TGCTCCCTCC CTAAGATATT GGCAAGTTTG GAGGGTTCAA GGAGAAACAG AGCATGTAGA GAAGATACCT CTCTCATAAC CATTTGTGAT TTACAAGTCT TACCTGATTC TTTTCAACTT AAAGGATGTA AGAAGGCTTT TGGTAGCTTC CATCTGATTC AAGGCTTTGG CAGCTGCTGT GGAATACATG AGAACACTAG GTAAAGCACT GTCTTCCAAC ATGAAGAGAG AAAAATATGT GGAATGTTCA ATGGCATGCT TTGTATAAGA ATGCAACTTA CCTGGCAGGA ACAAATTTCT TTGCTGCAAA AGAAAAGACA AACAACCATT AATTCAGACT AAATGACTTT TAAGGATATA TTAAATCCAG ATACAATATG ACTTAATTCA TCAAGTGTTG CAAACTCGAT GCTTCAGGGC CTCTGTAATA ATCAGAGCAC AAGCATGGCT CTGTGGCATC TAGGGTAAAA TGCAAAGTGC ACAGCCATCC AAAGGGCATA GCAGCTTCCT AATGCCAGCA AATAGCTACG GGGTCATCTT GCCCAATTCA GCTCCCAATT TTTCATGAGA AGTCCAAAGT CTTAATTTAA ATGTGAGATT TCCTATTTTG TAAACGTCAG AACTTAACTC AAAAATGTTT TAAGTACTCT TAAACATGTA AGCCAAACAA ACCATGAGTG TAGTCAGATG TGCTTCCATA TTCCTTATGA GAGACTCTCA AATTTAAGCC TGTACTCCAA ATAAATCTCC TTAGGAAGAA TTTTATCCAT TTTCCTTAGA GTGCTCATCA TGGCAGTTCC ATTGCACAAT TCCGGGAGGC ATCATATAAT TCAACATGAA TAGCACCCCC TGGAGTTGTA CAATATTAGG CACGACTAAC ATTTTTATTT CCTGAAACAC TTCCCACACT GAGTTGTACT ACTAACTCTT TTCTTAATAC TTCTGCTTAA TTATACTGCA TTTTATCCAG ATTCTAATTA TTGTTTAAAT CAGTAAGCAA GACCATGACT TATCAATGAG AAAGAAATGT ATTTTCAAAA ACATTTTTGA AGTACATTCA TAAACTTCCT CACCTTTCCG TAAGCATTTC CGAAGCCAGA GGAGAAATGG TGCTAATGTC AGGAGGGAGA GTCCAGCAGC AGAAAGTCCA GCTACCAAGG GAATGTTGGA CTCAGTGGGA GCTAAGGAAG TAAGAGACGA AGAAAGGTCA TGAGGAAGAA TTGATGTTAA AGTCTCTCCG TCCTGTCCCT TTGGCCTTTT TTCTGTACAT TCATTACTAG GAGCAGAAGA GCTATCTAGT TTAATACAAG AAGCAGAGAT GTGGCATTAC AGGCCTTTGA GATCTGCTCC AAGCCACCTT TGAAGCTATT TCCACCATTG GCAGGCAGAA CTCTAACTTG CCAAGCTCGT TCACAATACC ACACCACACC TTGGTTAATA AACACTGCAC TTGCTTGCTC TCTTGCTCTC ACTCCCTCTT GTTTTCCATT TCCCCTTTCT CCTCTCCTCT CTCTGTCTCC TTTTTCCAGT TGTCAGAATT CTACCCTTTC CATCAACATG CAACTTCTGT TTTTTCTCTA TCCCCATACA ACTTAATATT CACAACTTGT CAACCTGGGC GAACTTTCTG GTTTGGATAT AATGAATAGT TGATTACTGT AACAAGATAG CTCCCCCTTT TTCTTTTTAA TCACCAGACA ACCACCATCA ATCAATGCAT CACCTTCACA GGTAGGTAGC AGGCCAGACC AGTGTCCTGT GGCTCCACAT GTCCGAGCTG CAGAGCCATT GAGCGTCCAT CCTTCAGGAC AGGCGAACTT GCACACAGTG CCAAACACGG GCTCCCCACT GCAGCTCATG TTGATCTTTC CCGGAACTGC CAGGCTTGAA CATTTTACCA CTGCAAATGT TAGGTACACA GGCAGAGTTT CAGAAAAATC TACTGGAAAA CTTCCAAAAC TTGCTTAAAA GTCAACAATG AATGTAAAGT GTAAGCGCTA CTTAGTTTTC AGCATGTAGG AAATTAGGAC CAAACCCCTT TGGGGCAATC TAGGTTCAGA AACTTTATGA AGTATTTGAC CTGTACCCTA AAAAAGTCTG CACTCAATTC TACCTTGGCA GGAAGGAACC TCTTCTGTCC ATTGTCCCTG AGATGTGCAC TCAAGTTGAG TTGATCCATG TAATTCAAAT CCCTCCTCAC AGCTGAAGGC ACAAGAGGAC TTGTAGGTGA ATTCTCCAAT AGGGGAATGA GCACACCTCA CCAAACCCTT CGGGGGCTGG TGGACAGCAT CGCATCTCAC AGCTGGAACA CACGAGAGAG CACTTTAGAA GTTTGTTTGC ATCTCCAGCA ATACGTTTCC CAAGGTAACC AAGTTCCCAA GCTCTTCAAT AGTTCTTTTT ATCTTAAAAT AAAATAAAAA CAAAGACTGT ACCTTCACAT GTGGGCTTCT CGTTGTCCCA CTCCCCTGTG GGGCCACATT GGAGCCTTTT GGATCCCTTC AACACAAAAC CCTGCTCACA GGAGAACTCA CAGCTGGACC CATAACGGAA ACTGCCAGAA GCACTAGGAA GACAATTCAT GTAGCCTCGC TCGGGGTTGG ACAAGGCTGT GCACTGGAAA GCTGAGACAT CAAAATGATG GTCAGAAAAT ATTGCAGTGG AACTAGAGAG TACTTGGCGT TTGTTGAGTG AACCCAGTTC ATTCAAGCAA CACTTGGAGA ACTGAAGATT CTTTATAATT CCCTGGACAA ATGGGAAGAT GGCTGTGTTT TCTTTGAATT TCAGCCCCCT CACTGATCAT GGCACTAATT AAAAGACTAA TTAATCAGAA CATTAGTTCC TGAGCACTGT TCTTCTAACA CACAAAATAA ATTATGGTCC AAGGAAAGAT TTCACGCAGT CTGAGGACAA CATATGGGTC ATGGATGTTT ATAGATGGTG CCAAAAAGAA AGAAAAGAAA GCACCCCTAT AAAATTTGTC TGTTTTGCAG TTTGGTTTTT GTGTTATGTT TTGCTACTGG AAATCATTCT GTGCTGGCTT TGGCTAGGAC AAGGCCAGTG CCTGATAGTA AAAACTGCTT GTTTTCAATA TCCTTGCTCT CACTTTAAAG TGAATTAAAA TTTACTGCTT ATATATGCAT CAATACTATC TCTGTAGCTG ACACCATGCT TGAAACAGTC TCATCACTGC TAATTATGAG CCATTTCAGA AGACAGGTGT GATGAGAGTT TTACATTCAA ATCATGTTCT CATTATTCTG CTTTCCGAAT TTTCTAATAT GATTCCTTTA GATTAAGAAT TCTGTCTATT CCATGCTAAT GTCTACAAAG TTTTATCAGC ACATCACAGT TAAAAAAAAA CAGCAAAGAA TTCATTCTTA ACACATATGA TCCTTTCCCT GGCCAAACAT TAGTTCTTTT AAATGAATCT CAAAGATACG AGGGTTGCTC ATCAAATCTG ATTTCTATAG TTAAAGTGGG TATTGGTTTT TTTTTTCACT GTCCAAGTTT GAAGATGGTT GTTCTTTAAG AAAGTATAAA TCGAAGGATC

TCAAGCTTAC CTTCACAAAC TGGGATTTGC TGTGTCCACT GCCCTTGAGT GGTGCATTCA ACCTGGGCTG GTCCCTGCAA CATGAAGCCT TCCTCACAGG TGAAGTTGCA GGATGATTTG AAGGTGAACT CTCCAGCAGG GGAATGGCTG CACCTCACAG AGCCATTCTG AGGCTGGCGG ACGGCCCTGC ATGTCACAGC TGTAACAAAT ATACGCATTG ATATTAGCAC GGCCTAGAAT TAGCTTGCCC ATTTCCAGTA TGGGTTGAGA GAAAGAATGT TCACAGTAAG TCTCCATGTG GAACAACTCT ACCTTTACAC GTTGGCTTCT CGTTGTCCCA ATTCCCAGAT GAGGTACACT GAAGGCTCTG GGCTCCCATT AGTTCAAATC CTTCTTCACA GTCAAATGTA CAGGTTGTGT TCCATGGGAA GCTTCCAGGG TTTTGGAAAC ATTCCACGAA CCCATTGGCT GGATTTGTCA CAGCATCACA CTCAACCACT GAGGATTTTA AAGAGCACCA TGAATTTTAC AGAAGAATGA TCTTTTCACT TCCTATTGAG CTGGGTGCCT AACAGAGTGA GGAAGCTGCC TTCAAAGGGT AGATCCCAAA GTCCTATGTC AATTCTTAGG GACATGCACA GCCAGAATAA AAGCTTTTAT TCTTTTTCAT GGATATTCTA TCTTTTCTGA TTTCCACTTT GCCTATGCTG AGTGGTCTCT EPI-109 134

AATCTATGTT ATCATTTACG TGAGGTAAAA ATTTAAAAAA AATAGATTCC AGATTAGGAG TTATGACTAG TACTGACATA CGTAGGCTAT TCATTTATTT TAGCCCATCA GAGCCTGAAG AACTGATTTT TCTTTTTTTG GCCTCTGGTT CAGAAAGATA AAATTAAGAG AGAAAAAGAG ATACTAAGAC TGCTTGACTA TCATGGTCTT AAGTTAGTCC CATGGCTTGG AAAAGTTAAA CAGGGAAACA AGATGAGAAA TCCATTGAGA TTTCTAGAGC TTTATTGTTT TATGGTCTCC CTTACAAATC ACCAGAGCCT CAGAAACACC CATTTCAAGC ATAGAATAAA AAAACCTCTC TCAACCCAAG CAGGTACTGG GTTGGCAATA TACATTGGCT GAGAGAACAA ATTGTATTAA AAACAAAAAC AAAAAAAAAA CTTTCCCTGA AGTTTTGAAA ATGTAAGTTG AATCAAAAAA CAGAAGCAAT GAGGGATGAG TTACAGAACG TTCTGTGCAT TCTCAGAGGG ATTTACCATT GCAGGCTGGA ATAGGAGCAC TCCATTCTCC AGAGGACATA CACTGCATGG TCTCCATGCT GCTTGGCAGG TAACCCCTAT CACAGCTGAT AGAGCAGGAA GAATTGTAGC TGAAGTTTCC CAGTGGGTGA CTGCAAACCA GGCTTCCATG CTCAGGGGAT TCCAGGGCTG TACAGTTCAC AACTGAAAAA GAAACCCAAA TCAGTTCTGC TCATCTCTCA CCTTTAACAG ATAAGAACAC TGGAAACTAG AACTACAGTT TGGTTTTTTT TTTTTTTAGT TTAAAAATTT ATAAAATTTC TAATGGAATT TGTAAAATTG ACTGTAATTC TACCCCTTTT CTTTTATTCA AGAAAATGCT GATCCATAAC AACAACAACA AAAAAGCAGT GATGACAACC ATAAAAAAGA AATATTGAGT GATATGGGGA GAGTAGTGTA ATTGTGTTTA CCTCAAAACT GTTCAAATTA TATGAACAAA CACAGCAAAC TTAGGTACCA CAACAAATTT CTTGTTACTT TTCTCACAAC TGCTAAAAAT ACTACAGTAA GCTTCCAACC AGGATGAGAA CCATTCACAA AGCTATATTT CAAATTTAAG TACTAGAATA CATTACAAAT TTTAAAACCC TAATGCTCCA CTGTCTACTA TAGTAGCCAC TATCTGTGTG GCTACTCAAA TTTAAACTTG AATTCGTTGA AATCAAATAA CATTTAAAAT TCAGTTCCTC AGTGTCACCA GCCACATTTC AAGTACTCAA TAACCACATG TGGCTCATAG GTACACACTG GAAAACACAG CTATGGAACA TTTCCATTAT CACAAAAGCT CTACTGCACA ACGCTGTGCT AAGGAATCTT GGAGAGAAGC TCATCTAACT CTCTTAATGT ACAAATTTAG GAACTGAGAC CTCATTTCAT TCAAGTGACT TGCTCCATGC TACACGGCTA GTCATTACAG AGCCAGAGGC CAGAGCATGA ACCAAGATAC CCTGGACTCT GTAACTCACT CATTTCTACT GCAACGTCTT GTTACCACCT AGATGAGGTG AGTACATGTT CCTCGCAGGG ACACAGAATT ACAGTTTATT GAATGTGTCC TGTGTGCCAG GCACCATGTA ACCATGAGCC TATGAAGTTC ACACTATTAT TATCCTCATT TTACAATGAG AAAACTGACA TAGAGAGTTA AACTATCTTG TCAAGGTGCC AAAATAAATA ACTGGTGAAT CTAGGACTCA AACCCAGCAG GGTCTGACTT CATAGTCTCA GCTCACGATC ACCATATGAC ACCATCTGCA CCAGGGAAGG GAAGGCATGC AGACCTGACT CTAATGCCAG CTAGGACGTG AGATGGTGCT ACCATCTCAA GTGAAGAAAG AGGCAAGAAC CAGACTTACT TTGCTCACAC TTGAGTCCAC TGAAGCCAGG GTCACACTTG CAAGTGTAAT TATTGATGGT CTCTACACAT TCACCGTGGC CACTGCAGGA TGTATTGGTA CAGGCAGCTA CGGAAAATAC AAAGCATGAT GAGGAGGACT ATTACTGTGC TTATACTGAG TGCCTTTGAT TTTAGAATCA ACAGTGTGCA ACAGAGACAT CAGCAGTCCT ACAGAGTGCC ATAGACTTTA ACTGAAGTGT TTTACAAAGT TCCAAATCTG AGTTTCAGGC CCACCTATCC TAAACCTTGA TGCTAATGTA TAGCTGTGGC TGGCACCTAC CGTAGAAAAT TTACTTCTTC ACAAACTCTG AAGACAGTTC CCCTACCACA AATAAACAAG TAATTAAAAT ATGTATTGTG TGTGTGCATT TTTATATGTA AAGAACTACA TATTTGCCTA CAGTATTTAT ATATATTTTA TATATATACA TACACACATA TATGTGTGTA TATGTGTGTA TGTATATATA TAAAATGTAT ATAAATGCTG TAGGCTATAT ATATATACAC ACACACATAT ATGTGTGTGT GTATATATGT GTGTGTGTGT ATATATATAC ATATCCACAT ATTCTTGCCC ACATTCACAC AAAACAGCAA AAGAGAGAAA CTTTAGCAGT TAAACAGAAT CTTTTGGAAC ATAAAATGAC CACAATAGAG AGCAGTTTTT GCATGCTGTA AATTTGCCAA GATGCCCACA CACTGAAACT ACCTCCCACT GCTGCCGCAA ACTCCCTACC TGTGTAGCAT AGGGCAAGCT TCTTCTTGCT GCACCTCTCA TCATTCCACA TGCCCACATC TTTTTCTCTC TTGATGTAGA TCTCCACGCA GTCCTCATCT TTTTGCCTAT TGTTGGGTTC ACCTGGAGCC CAGTTCTTGG CTTCTTCTGT CAGAGGTTTC TGGGTTCCTA CCCAGACCCA CACATTGTTG ACTTTTCTGA TTCCAATCCA GTAATAACTT GGTGAATAGC TCAATATGGA GTTTAGGTAC TCAATCTCTT CTTTGTTTTG AATTGCAACC AGGTGTGTGT ACCTTTGCTG ACAATAAGCA CTGGCCTCAT CATAAGTCAT AGCTTCCGTG GAGGTGTTGT AAGACCAGGC TCCACTCTCT TTAATGAGAA GCACTAGTGG GAGAAAAAGA AAAGAAATGG TAGAGTTTGG TACTGTTGTG GTTTAACTCT GACAACTGTG CTTTTTATTG TCTTATTTTT GGCAATGTTT GTGACATGGC CCAGACTTTT CTCATCTTTT CAAAAGTAAG AAGTACGTAT GAAGAAACAG CGACTTATTG TTTATCTCTT TTGTGACTGC CACCCACTAG GTACCTTATC CACACTCACT CACAACATTA TAGTATACCC ATTTTGTAGT AGAATAATAA TCAGAATAAC TAAGCTTTAT TGAGCACTTA GTATGCACCA AGAAGCACTG TATGAGGTAC TTTCCATGAA CCATGCTATT GAATCCTCAC AATGCATCTG GGAAATAGGT CATTATGATC CACACTTTAC ACTTAAGGAA AGGGAGACAC CAAGAGGTAA AGTAAATGAC CCCAAGCCCA GGGAAGAACA CATTGCAGGT AGAGGTCAAG GATGCTGCCA GATATCCTGT GCAGGACAGC CCCAGACAAG CAAGGATATT TCAGTCTGAA ATATCTATAG TGCGAGAATG AGAAATCTTG GTCTAATGGC ACTGACTTAC CCAAAGTGAG AGCTGAGAGA AACTGTGAAG CAATCATGAC TTCAAGAGTT CTTTTCACCC AAAGGTTTAG GCTTGAAATA CTTTCCTGGG GAGATAAAAC ACAAAATGAA TTAAAGAAGG AAATCGTGGG TAGCTAGTTA CATTATTCTA CCATGATGTT TAAGGCAGCA TCCTAAGATT TTGGGCAAAG GACACTAGTG CAATAATCTT TATTTCAGAG TTTAATCAAA TAAATAAACA AATTTTAAGA CTTTCATTAT TTAGGTCAAA GAGAAAAGAC AGGTTTTAGC TACAATACAA TAAGAGCTTG TACAGATGTG GTTTTTATTA GAAGGCCTTT TGCATATCTG TGTTTCATGG CCCGAGGCTG CCCTTATAAA GCGTTCTGCA CTTACCGTTT TGGGAAGCAG TTGTTCAAAC ACAGGATCTC TCAGGTGGGT ATCACTGCTG CCTCTGTCTC AGGTCAGTAT AGGAGTTTTG ATGTGAAGTC AGCCAAGAAC AGCTGAACAC TACTTCGGCT GAGGCCCTTT TATAGGAGGG ATTGCTTCCT GTGAATAATA GGAGGATATT GTCCACATCC AGTAAAGAGG AAATCCCCAA TGGCATCCAA AAACTTTCCC GGGAATATCC ACGATGCTTA AAATTACAAT GATGTCAGAA ACTCTGTCTC TTGAAGCTAC TTCACCTTTG TCCATGCCTT TATATCGTAT ATGCAATTTT ATTAATATGA CAAAAATGCA TGATTTTTAA TTATAATAAC ATAAAGTCTA TGTCTTTAAA AAGTTGTAAA ACTTTGCTTG TTAGTAGTGT CTCTCATGTA GTTGTGGTAG TAATTAGAAT TTCAGAAACA GAAGGAAACC AAGAATAGGT TTGTCATCCA TAGTCTACTA CCTTCAATTT CTCATTCATA GCTGTGGATA ACCAATCACT ACTCATTTTT TCTTCCTTTT TCACCTGCCA ATTCAACATA TTTAACATGC ACTGTCTCAC AGAGGAATGA CTCACAAGGT AGATATTAAT CTTCAGATTT TGCACGGCAG TTATGCCTAA ATTAAAATAT TATCTAAAAA TAATATCTAA CACTCAAATG GTTAAAATAA TGCCTTATTT TAAAAAAAGA AAAATGGGAA ATAGATATTT ACATCTGGGA AAGTTTCATG GTTTGTTCAG TGAAAAAAAT AAAAAGGAGG CCAGGCACAG TGGCTCACGC CTGTAATCCC ACCACTTTGG GAGGCCGAGG CAGGCGGATC ACCTGAGGCC GGGAGTTCAA GACCAGCCTG ACCAACATGG AGAAACGCCA TCTCTACTAA AAATACAAAA TTAGCTGGGC ATGGTGGCGC ATGCCTGTAA TCCCAGCTAC TCGGGAGGCT GAGGCAGGAG AATCGCTTGA ACCCGGGAAG TGGAGGTTGC AGTGAGCCAA GATCACGCCA GTGCACTCCA GCCTGGGAAA CGAGTGAAAC TCTGTCTTAA AAAAAAAAAA AAAAAAAGAA AAGAAAAGAA AAAAAATAAA ACGGAAAACT ATATATATAT ATTTAATTGG TCAAAATTTT GTTTAAAATT TTTGAAATGT TAATGTGCAA AGAATAAAAA TTCTTCCACA ATGTTAACAG TGACTAACTC TGGATGGCAG GATTTGGGAT AATTTTTATA TCCTTCATTA TTATTTTCAG GATTTTAAAG TTTTTTTCAA TTTCCCTTTT TTTCACCTTT ATAGTAACAA GAATACAGTT TAAAGAAACT TGTCTCTAGG CCAGGCATGA TGGCTCATGC CTGTAATCCC AGCACTTTGG GAGGCTGAGG TGGGTGGATC ACCTGAGGTC AGGAGTTCCA EPI-109 135

GACCAGCGTG GCCAATATGG TGAAACCCTG TCTCTACTAA AAATACAAAA ATTAGCCGGG GTGTAGTGGC GCATGCCTGT AATCCCAGCT ACTGGGGAGC CTGATGCAAG AGAATCGCTT GAACCCAGGA GGCAGAGGTT GCAGTGAGCT GAAATCACAC CATTGCACTC CAGCCTGGGC GACAGAGCAA GACTCCATCT CAAAAAAAAA GAAAAAAAGA AAAAGAAAAG AAAAGAAATT TGTTTCCAAA TGCAACAGAA GGAGATGTAT GTGGTATCCT ATATTCCTGC TCTTCATTTT GACATTTCTT CTGGGTGATT GTATACATTC CCCATCTCTG CATCTTACCC TATCTAAATG ATGGTAACAG TAAATGGGGA TCATTTTAAT TTCCATATTC TGTAGGTTTT CAGAGCTCAA GTCAAGCTAA TATTCTATAT CTACAGCCTT TCAAAATAGG AGGTCTATCT AAAAATGTAC TGTCAGCAGA CCTGAACGAG TAGTGGTAAA AGCCTCGTTT TTCTCTTTAC TTGTTAGCAC TGGTCTTTCT GTGTTCATAA AGATGTCAAG ACCCAAAAAA AAAACAAGAA AAGAGAAGAA AAATTCCAAA AAAGACAACT GATTAGAAAA AAATAACTTA ATTAACGAAT TTAATTCAAC CCCTATCAAA AAGCATAGAA TTTATTCCCT CCACCTTACC ACTCTCTTAC ATGATCCAGA TACTGACATT ATTCCAATTC TTTATCCCAC TTTACTTAGC TCAATGTGGT TGTTGCTTCA ATAAATTCAG AAGAGTAATC ACTCATATAG TGTTTATTTA GATTTTAGGG CAGAATGTCA AGTTGGGTTA ATACATTATC TGTATGTATT TTATTTTTAA TAAAGTATGA ATACATAATC TGCTATTTTT AAAAAGCATG GTCAAATGTA TAGAGTAGCC AAATCTTAAA AAACAATTTA TCTTCGATAT CAATAAAGTA CCTAATAATT ATATTGCTAA TAGAAATTAG TCGTTAACAT CCCTAGATAA CTAACTTTAT TATTGCGAAT TTTTCATAAC TAAGTTTATA GTTTATCTCT TCCCCTTTTT AAAATTAGTT CAAAGATATC TAAAAATAGC CCCAGTGGTG ATGAAGTTTC TATTTTACTT ACATATATAT GTCCTGGACC CCCAATTATA ATCTCTAACA TTTATTGAGT GCTTACTATG TGCCAGGCCA TATTCTGAGC ATTTTGTATG TTCACCTATT GATTATTCAA TCCGTACAAC AGCCTATGAA ATAGGTACTC CTATTATCCC CATTTTACAG ATGAGGAAAT TGAGAATCTG GGGATTTTAT CTCATTCAAA AGCACAGAGC TAAGGGTTGA AACCAGGCAG TTGATATCCA GAGCCCACTC CCTTACCTGC TACTCCAAAC CATGATTTCT TTTGTTGTTA TGCCCCGAGA TTCCTTGTTC TACCCAAGTT TCCTGTACTC TTCTTGCCCT CTTCTTCCTG AGACATCCTT GACCATCACA GCTCTCCACT GAGATAACTG TGTCCTGGGT TCTGAGACAT GGGGGCTGGA AGGGACCCCA GGGACAGTGA GCAGTAGGGA GAGGATGCAG TGAGAACAGA CCCTGGATCC CCGGTGCATA GGCAGGGAGA AAGTGGACAA AGGAAAAAAC AAGCAAGGCA GGTGGAGCCA TGCCTAGGTA AAGTTGATCC CTAAGCCACA GTTCCCAGAA GTTCCTGATT CAAAAGCAAA TTTTCTCTAA GGTCAAAGGG CAAACTGATT ATTCTAAATT CTAAACTGAT TATTTCTAAA TTGAGAAAGC TTCAGGGAGA GATCCCAATA TTCGAAGGAT AAGAGAAATG AGGAGTGGAA GAGATAGGTG AGTAACAGTA ACTTAAATGT AGACTATATA TAATATATAA TATATGTAGA GTATATATAT ATAATTACAA TATATTATAT ATGTGGAATA TATATATTAT TTATATATAT TTATATATTT TATATATATA GATATTTTTA TATTTTATAT ATAAATATAG ATATTTTTAT ATTTTATATA TAAATATAGA TATTTTTATA TATATTATAT ATAAATATAT GTAAAATACT GTGAAAGAAG AATAGAATCT TGAGACCTCA AATTCACTAT GCCAAAGGGA AAGTTAAGCT TGGGAAATGA GTCATGCAAA AACTGCCTTC CTTTTGTTCC CAAATACCTG TAATTTCACA TGCTTACTTT ATCTTATATA AAATGTAGAT GTACTGAGCA TGAGATCCAT GCATAATTTC CCTCTAGTCC CTTCTTTTTA CATGTAAAGT GTAGACTCAC TGAGTGTTAC AGAGCCTTGC CACAATGTAA ACACTTGTCT CATTGCCAAC CCATCTTTCG TTTATTTTCT TCCCCTCCTG CTTGCTCTTT CCCCTCTAAA GATGGAAGTT CCCAAAACTC TCTTTGGAAA AAGCGCAGGT CACAGATCCT ACAGTGATTT GTGTTTCTTT TACCTGGGAC AAAATAAACC TCTAATCTGT TGAGATATGC TTCAGTTACT TTTTGGTTTA CAATATGTAC ATGTATGTAT ATAATTTATA TGTATATAAT ATATGTACTT GTTTTAACCA GAGGTATGTT ATTCAAAATC CATTCATCCT TACAATTACC TGCATTCTCC CACAGTATTT TCTGTGTCCC TGCCCCCGAG GTTGTCACTG CAAATCAGGT ACATGGATAC TGGGAGCTGA TGGGCTCCCC TCTGGCTACC TGGGCTGCTG AAGGGGCCAT AGACAGACCC AGCTTTCCTC TCGTGGAGAG GCCCTGGGCC AGCGCTGCGT GGGAGTGGGA TTACAACCAG ACTATAGCTT CTTCACCTGC TTTTTCCTAT CAGGATTTCA TAAGAGGCAA TTGCTTGTTT TTTGAGGGTG GGGGCAAATC AGGGGGAGTT GAAGAGGAAA TTGGGTAAGA TTTGAATAGT TGGGCATGTT GAATATTATG AATATCATCT CCCTCTTCAA ATAATCCAAA ATATACCCCC AAGAAACAGG CTGATTAGAG GTGCTTCAAG GCTCCACTGA ATCTCCCAAG CTCTGAAGAT GTAGCTAGCT GTTACCGGAT TGCCGGTTTT CAAGCCTCGC CTCACATGGA CCCTCTTGGC AGTTTCTCGC ATGGGGGAAG CATCCGCTAC ATAGATGGGA ATGAAAAGAG GAAAGAAGAC GGTGCAAACT CAGGCACACC CCGGTGTCTG CCACCAGTGC TATTTAATCT CTGAGGTGTC ACCCTTCCTG GCTTTATTGT CTCTTCCTGG AAGTCTCTTG TCCTCTCCTC CACACCCTTT AATCAGGCAT CAAAGACTTT AACCAGTTTT GCTGTGTGCC CAGGCCCACT CATTCTCACT TTTATGGCAA AGGGAGTGGG AGACAGAGAG ATAGCCAGAA AGAAGAGATT GGGGACCCCA AGACAAATGT TAGAATTTTA ACCAAGGCCA CCCTGTGGAC AGGAGATTAT TGGGTTTAGT GGAAAGCAGC ACTGGCCACA ACCACACGTG GCAAAAGCAT CTATCGAGGA GTGAAGTTAT ATTTGGTGAA TGTGACCGGG AAGCAGGGGC AGTGGTGTCC TCCTGCCTTC CTGAGGCACT CTGTTCCCTT ACCTCTGCGA AGGCTTATTT TACCCCTGAG TGCTTAGTTT TGAAAGCCTT AGTTCCCTCT CTCCCATAAA AAAGCTCTAC TCTGCTAACA TCTAAGTTAC CTTTGCAGAG TCTTAGGTAG AGGGAGGAAA TCCCAATAAA GATTCCACCC TATCTGCAAA ATACAAACAT GGTATTTCTT GCATTCCCAA AATTGTGAAA GAAAATGTGT ATCACCACAG TAGAGAATGG CATTTTTTGT TTGATCAAAA CCTAAATATA TTTGATGAAA ATGTGTCTGG TTCTAAGTTT ATTTCCCAGA AAGCCATGTT TACTCACTTG GAATTTATAG ACATCTTATA ATATCTGAGT CGAGTAGGAG CTCCGGGCTC TACCTCACTC TTTTCTCCCA CACCCAGGGG GAAGTGTAGG GTTCTCAGAC TTTAGAATAA AGAGGAATCA CCTGGACAAC TCACCTAAAA TGCACATCTT CAGGTCTCAT ACTCAGAGGC TCTGACTCAA CAGGTCTGGG TGGCGCCCAA GAATTTGGGC TTTAAATGAG TATCTCAGAT GATTCTAATA CAGAATGTGT AAGATGACCA GATCCTATCA CACTTAGATG TATTGGCCTA GGGCCACCTA ACTTGGAGAA AATGTTAGTA AGACCCCGTG GTTGGTGCTC AGCTATAGGT ACCAGAATTT TGATCAAAAT TTACTATCAT TGTGACACTT CTCTTCGGAA CTGGAAGGCC AGAACCCCAC TTGTAAAGTG CTGGGAAAAT ACAAGGAAAA TTTAGGGTGA GTAGCATTTT GAATTCTTAC ACATGGAAAG TAAATGTATA AGAATTCTTA CCAATAAAAA AAAAGCAAGA GAGAATAGCT GCTAAAGAAT TAACACAAAT ATGTATATAT TAGTTATTCT CTTTTCTCCT CTGATTCCAG AGGACTTTGT AATTCCACTA ATTCTTCTTG AGCTTCCAGG ATGATCTGAG ACTTGAATTT TTCATGTGCT TTTTGCTTCC TATTTGGCAG CATCTTATCT TGAAGTTTCC GCTTTCTGCT TGGGGACCTA AAAACTAACT AATGGGAATT TCTTCAAAAT GAGCAAACTC TGGTGAATTC CCAAAGCGGA AGAAACAAGT GAGGATCGGG CTGGTTAATT AAGAGAACTT TTCCTGAATG TAGCCAGACT GTTTGCCGAC TGTTGTTAAC ATGAGGGAAG AAATACCCCT GGATTTTAGA AGAGCCCCTT GTTTGTTTTC CTTGGCCATT TGTGCTGCTT GTTTTGTAAG TCAGAAATTT CCTGAAGGAC TATTATTAGC TTTGTTCTCA CGTCAGAAAA CTTCTGCTCT GGCCACTTTT AAACATATAA CTTGGATTTT ACTGTATTAG AAAATGTAAC AATTACAGAC AGCACTAAAA GGACACCAAA GGGCAAAGAA AATGGGTAAC TTTTTTTTCT TCCCCAAATC TAAAATAGGT GATTTTGGAG AAGTAGGAGA AAAACCTGGA TTTTCTAGAT CTCTTTAGAG CTCAACAACT GATATAGTTA ATTATGTAAG TCTTTGATAT TTGGAAATGA TTGGATTAAC CGGATAACAA TGAATATTTA AATACAGTGA TTTGGCCAGG AGCAGTGGCT CATGCCTGTA ATCCCAGCAT TTGGGGAGGC TGAGGCGGGT GGATCACCTA AGGCCGGGAG TTCCAGACCA GCCTGGCCAA CATGGTGAAA CCCCATCTCT ACTAAAAATA CAAAATTAGC CAGGCGTGGT GGTGCAAGAC TGTAATCCCA GCAACTCGGG AGGCTGAGGC AGGAGAATTG CTTGAACCCG GGAGGCAGAG GTTGCAGTGA GCCAAGATCA CGCCATTGCA CTCCAGCCTG EPI-109 136

GGCAACAAGA GCGAAATTCC ATCTCAATAA ATAAATAAAT AAATACAGTG ATTTAACACA AGAGATTTCT ATTTCACACT AATGAGCTCT GTCACTGGGG CAAGCTTCTT TGCCTCATTA AGTCTCAGAT TTCCCGAGAG CTTATTTATT TATACCAAGA GTGCTTTACT ACCGTCTCTG CTAGCTGTGA CATAATATGA CAAAAGGTAT AAATATGGGA AAAGGCACTA ATTTATATCA AAGCGTTCTT CGTTTTTCCT TGCTGTGAAG TTTTTAGCTA ATAATTCATA AGAATATACC ATATTTAGAG TGTTTACTAT GCATGGGCCT GGCACTTCAC ATACATTGCT TCTTACAAAT TTTACAAAGT GAAAGGTAGA TATTAATCTC ATTTTATGGA GGACAAGATA GAGATCTGGA GAGGTTACAT AACTTGCCAG TGTTTTTTCA GTTAATAAAT GGTAGGGTGG AGATTCAATC TGTGTTACTC TAAAGTCCGT GTCCTTTTTA TTGGCTCCAT GCCTACTCAG ATTTAAATCT CAGCAGGGAA GTAAACCTTA GTTTTTACAT GAGAAAATGT TACAGCAGCC TTCTCGGCTT CCTTTACCCC CATCCCAGTT TCACGAGCTT AGTGCCTTAG ATCGGGTTCC TTTAGAAGCA GACCTCGAAA TAAGGATGTG GGTGCCAGTC ATTTATTGAA AAGATGATCC CAAGAAAGCC TAGTAGGAGA GTGAGGAAGT GAGATGGGGA AAGGAAGAAA CTCCACAAGA AGTGTGTTAA TAAGCAGGTT ACCGCTGTGG GCAGCCATGG GGCTCAGCTG CACTAACAAA CTCTGTCTAG TACAGAAAAC CTCAGGGTCT CCCCAAGGAG GGGCAAGAAG TCTGCCTAGG GTATATATCC GCCAACTCAG TCACTGGCTG AGAGCTGATC CTGGGAGGGC ATGGTTAATT CCTCTGCACT TTCAAGTGGA TTCCTGTGGT CAGAAAAAGC CCTCTACAAT GAATTCCAGA TGCTTGTATT TAAATCTGAC ATGATCTGAA TGCTGTGTTG GGACAGGGTG GGCGTTATTA GTTTTCTGTC ATTACTGTAA CAGATTACTA CAAACCTGAT GGCTGCAAAC AACACATATT TATTATGTCA TAGTTTGTGT GGGTCAGAAG TACAGGTTAG CTCAACTAGT TTCTCTGCTC TAGGTTTCAC ATTGCCAATA TCAAGGTGTC ATCCAGTTGG GCTCTTCTTG GGAGGCTTGG GGATGAATCC ACTTTCAAGC TCATTCAGAT TGTTGGCAGA ATCCAGTTCC TTGTGGTTGC AGGACCAAGG TCCCTGTTGC CTTGCTGGCT GTTGGCCAGG AGTCATTCTT AGCTTCTAGA GACTACCTGT ACTCTCTGAC TCGTGTCTCC ACTTCACCTT TCAAACCAGC AGCGGCTAGT CGAGTCCCTC TCTTCAAATG TCTCCAACTG TGCCTTCACC TCATTTCTCC TCTGTGTACC ATGTCTGCCT CTACTGCTTG TAAGGGCTCA TGGGATTACA TTGGATTTAT TCAATCCAGG ATAATCTCCA TATTTTAAGG CTAGCTGACT AGTGATCTTA ATTCCATCTA CAAAGTCCCT TCCAATAGTA CTGTATTAGT CCATTTTCAT GCTACTGATA AAGACATACC CAAGACTGGG CAATTCACAA AAGAAAGAGG TTTAATTAGA TTTACAGTTC CACATGGCTG GGGAAGCCTC ACAATCATGG CAGAAGTCAA GGAAGAGCAA GTCATGTCTT ACATAGATGG CAGCAGGCAA AGAGAGAGAG CTTGTGCAGG GAACTCCTCT TTTTAAAACC ATCAGATCTC ATAATACTTA TTCACTATCA CAAGAACAGC ATGGGAAAGT CTTGCCCCCA TGATTCAATT ACTCCCACCA GGTCCCTCCC ACAACATGCA GGAATTCAAG ATGAGATTTG TGTGGGGACA CAGCCAAACC ATATCAAGTA CCTAGATTCA TGTTTGATTA AACAACCAGG GAGCAGAAAT CTTCAGGAGT GGGGGGCATC TTTAGAATTC TGCCCACCAA GGCTGGGCGC GGTGGCTCAC ACCTGTAATC CCAGCACTTT GGGAGGCCAA GGTGGGTGGA TCATGAGGTC AAGAGATCGA GACCACCCTC GCCATGGTGA AACCCCATTT CTACTAAAAA TACAAAAATT AGCCAGGTAT GGTGGTGGGC ACCTGTAGTC CCAGCTACTC AGGAGGCTGA GGTAGGAGAA TCACTTGAAC CCAGGAAGCG GAGGTTGCAG TGAGCCAAGA TTGCGCCGCT GCACTCCAGC CTGGGAGACA GAGCAAGACT GTCTCAAAAA AAAAGAATTC TGCCCATCAT AGTAGGCTGT CCTACAGAGA CATAACCCAG GAATTAGGTG AATGGCTAAC CTAAATTAGC ACTGTGATGT GTTTTCTGAC TTGGTCCTTA TAGCTCCTCT GCTTAGATGT GGAACTAATC CATGAATGCA AGGGTTTGTC TAGAGTTTTA AGTGGGAGTT AAATATCCAA AGTACAGGAG ATATTATGGG TGCCTCATCC ATGTCCCCTT GGCATTTATC TTTCTTGGAT AACCCAACTC TATTAGTTTT TATATCTCAC TTGTTCCTAT ACTCTGTGAA CTGATGTCCC ATAAATAGAC ATTTCATTTT GCCAGTCTTC TTGAACAATA ATTACGATTA TTAATCTAGC AGTTATCATT AATTGGCCAC TTCACATTAG ACACAGCACT TAGGACTTAA GAATACCATG TCATTTGATC ATCATAATAT GGTCAGGAAT TAAGTATTGC TATCCAAATT TTACAAAGAA GGCACTGAGG GTTAGAGTTT AAATAACTTG CTTAAGATGT CATAGCCTGT AAGTGACAAA ACTAGGACTC AAATACAGGT CCATCTGACT CCAAAGTCTA TGTTCTTGGC TACCACACTG CCTCTCCTAC AAGTGACCTG TGGTTTTACT ACTATATTCA CACTCTACTA ACTTTACCAT CTCCCATGAG TCTGTCTAGA GGAGGGCACA CACAGCACAG AAAACACATG AATGCAAAAT AAGGAAGGGC CTACTTACTA CACAGAGCCA TTCTAATACC TGATGTTTGC TCTAATCCAG TTTTACTATT AATTAGTTGC TGGTGCCCAA GTTTTTACTG AGAAATGGGG ATAATTTTGG AAGTCATAAT GATGCCTTCT TCTCATAGGG TATTTTATTT GTTGTTGTAT CTCCAGGCCC CAACACAGCC TGGCTTTTAG TAAATGATCA AAAATACCTG TTGAATGAAT AAATGGAGTC ACCTGAAACA TGTTAAACAT TTGTTCATGT GTCCTAATCG TGGATTTCAG GATAGTAAGC ATCCTAAAAG GAAAGCATGC ACACTGTTCT TGCTACATTA ATTTCTCACA ATATAAAAAA AGAAAAGCAT CTGAAAAAAG CTGCCAGCCG CTGTGTCTCC TAATATCAAA CTGAGCACAG ATATGGAGAA GCTAAGGGAG AGGGATGATG GGCCATGCCT CTAACCTCAT CATGGCAAAA GTCCTGGGGG TCAGACCCGA GGAGAGCAGG AAGTGTCTTT TGAGGGATAC ATTTCCACAG TGGAAATAAT GAGACTTAAA TAAATATTAT ATACACAGTT CAACTGTTTT TATGTGTAAA GGTAGTAGGT TTTCACAGTA AGGAAGCACT TCTTTTTTTT TTTGTTTGAG ACAGAGTCTC GCTCTGTCTC CCAGCCTGGA GTACAGTGGT GCTATCTCGG CTCACTGCAA TCTCTGCCTC CTGGATTCAA GTGATTCTCC TGCCTCAGCC TCCCGAGTAG CTGGGACAAC AGGTGTGTGC CATTACACCT GGCTAATTTT TGTATTTTTA GCAGAGATGC GGTTTCACCA TGTTGGCCAG GCTGATCTCG AACTCCTGAC CTCAGGTGTT CTGCCCGCCT CTGCCTCCCA ATGTGCTGGG ATTACAGGCA TGAGCCACTG CACTCACCAA GCACTTCTAC TGATAGCATT TACAAACCCT TCTTAGAATA TTTAAAAATT CTAAGAGAAG AGTAAATTGA GCCTTCCCAA CTAATACTAG GAGGTTATAA CCTTCATACC AAAACTGGAC AATGCTTGCA CAAAAGAAGG AAGCCAATGA GGCCACCTAG AAGGAAGACT GGGCATTGGG CCCAGTGAGT CCTGGAAACC TCATCTGTGC CAGCCACCCC GGCATGGCCT GTATGAGTGG ATGAGGGTGA CTTGTCCACA GACAATAGCC ATCTAGCTGT GATAAAGGAG TCAAGGTAGT CAGCTGCATC TCTTTCACCT GTTTGCCAAT GTTACACAGG TTGAAAAGCT AAGGTTTATG TAAAGCAAGC ATCAAAGATG ATGAAATGAT CAACCTGACA ATGAGTACTA TGCTGCATTG TCCAGAAAGG AACTGTGGAA GATTTTGGGC TGAATTTCAA AACAGAATTT CCTCACTCTC TGGATGTTGG CTTACTTGGC CTTTGATGTT CAGAGGTGGT GCCTTTGTGT TGTTGAACAA TGTTGATTTT GGAGAGAAAA CAGAGTTGAA AAACCCACAA GTCATTCCCT GGGGAGTATT ACCGGAATAC AGAGGATAAT TTCAGCAAGC CAGCAAGGCC TCATCTCTGC TTCTAATAGA TAGGAAGAAA GGAAGAGAGG AACAATACTT TTTTAAGAAG CTCAGCTTTA TCGCCTTATC TCATAGAAAG ATGCCTCCAG TCTGTCTGGC TAAAGGTAAT TGGCATGGGA AAGTCTTTAT CTGTGATTCT AACAAGTGGA ATGTTTCCCT TCATTAAGAG AGCCTTGTCT GGCTTGGGGA AATGAAACAC TTTCTCCGAT ATGAGTGGGC TGTAACCCCT GCTACTAAAT ACTCAGAAGA AATAAGGCGG TTGTGGAGCA GTCAGGAATG AGTCACTTGC CTCCCTGGAA TATTCAGAAA ACTGAATCAA AAGTACATTC TTCTGGGTTT TCTTAGTCTA ATAGACTAAG GGTCTCTACT TTGTTAAATT TCTGGGAAAC AGCATAGAAT GGGAGAAAAA ACTGGTCACT GTAGTCATGC AAATCTGCAA AACAAACAAA AAAGTCTGGG TATTGCTGCT AACTAGCTAT GTGACCTTAA GCAAGGTATT AACTCTCTCT GAATTTCAGG TTCTTCATCT GTTAAATAGC ATATCTGTAA AATGGGAATT ATTTTCATAT CATAATGCTG TAGCTTTAAA AAATAAAATA AAATGGATGA GATAATCAGA ATTAAAGAGC CTGGGATATA TACTTAATAT ATAGCAGCAT GTAAAGATCC TGTTAGAAAT GCTAATTTTA CAGTTAACCA TTTGGAGATG ATCCGCCAAA GCTGCTAGTG TAGAGGCAAC TGAGAATTTG CCTGTCCTTC AGAATATGAA TAAATAACTG TCAATGATGT CTCAAGCCTA GAAAAACCTA TCCATCTGGA TGGGTGGGAA ATTTCTAGGC TAGTATTGAG AAGCCCATTT CTTGGGAAAT EPI-109 137

AGGTCCTGGA CTGAGTGAAG GAAAAGAAAC AGTAAAACCC ATGGTAAAGC AGCAAGGCTC TCTAGAGGCT CTGGAGAGGA TGAATTGAAT TCTAGAAGAT GAAGTAGGGA AGACGCTTTA CCTTCTTGTG AAATGGATTC AAAGATTCAA AGACCTTCGG GAATCTCCAA TTGTATAAAT GGCACCATAG CTGTATGTTC CATGGAACAC TACTTCCCAG AGATGCCCAG TGAAAAAAGA ATGCCACAGT CAAATAAGTT TGGAAACACT CCATTATGTG GCCACCTCCT TGAAGACTCT AATGCACATT AGCATGTTAA ACAGTCTTGA GAAGTCCTGC AGAGCAGAAA TTGCTTCACA TCTGCTAAGC CGGCAGTTTC CCAATATACT TGATTATGGA TAGTTTTTTC CTTACAACAC CATTCTCTGA TATGCTTCCA ATGACATGAA ATAAATATAT ATGCATGAGG TTCTTCATTA GGGCATACTT TTTAATAGAA AATATTGAGA ATAATCTAAA TATAAATGCA CAGCATTTAC CTTTTCTGCA TAAACTATAT ACAGGCATAC CTTGGAGATA CTATGGGTTT GGTTCCCACA ATATCTCCAA AACCACATTC GGTTTTATGA CCACTGCCAT AAAACCAGCC ACATGAATTT TTTGGTTTCC CAATGTATAT CAAAGTTACA TTTTTACTAT ACCATAGTCT ATTATATATA CAATAGCATT ATATCTAAAA AACAACGTAA ACACCTTAAT TTAAGGCTGT GGCTGGTTTG ATTTTCTACC CAGACCACTA AAACTTTCTT CATATCAGCA ATAAGGCTGT TTCACTTTCT TACTATTTTT TGTGATAGCA CTTTTCCTTT CCTTCAAGAA TTTTTCCTTT CTATTCACAA TTTGTTTGAT ACAAGAGGAC TAGATTTTAG CTTATCTCAG TTTAAGGTGT TTACATTGTT AGCTAAAAAT GCTAATGATC ATCTGAGACT TCAGCAAGTC ATAATCTTTT GCTGGTGGAA GGTCTTGCCT CAGTGTTGAT GTCTGCTGAC TGGGTGGCTT TGGCAATTTC TTAAAGTAAG ACAACAATCA AGTTTGACAT ATCAATTGAC CCTTCCTGTC ATAAATGATT TTTTTTTTCT CTGTAGCCTG CAATGCTCTT TGATAGCATT TTACCCACAG TAGAATTTTC AAAATTGGAG TCAATCCTTT CAAACTCTGG TGCTGTTTTA TCAACTAAGT TTATGGAGTA TTAGAAATCC CTTGTTGTCA TTTCAACAAT GTTCACACCA TCTTCCCCAG GAGTATATTC TACCTCAAGA AACCACTTTC TTTGCTCATC TATAAGAAGC AGCTCCTCAT CCACTAAAGT TTTATCCTGA GATTGCAACA ATTCAGTTAC ATCTTCAGGC TCTACTTCTA ATTCTAGTTC TCTTGCTGTT TCTATCTCAT TTGTGCTTAC TTTCTCCGCT GAAGTCTTGA ACCCCTTAAA GTCACTCATG AGGGTTGGAA TCAACTTCTT ACAAACTCCT GTTGATGTTG ATATTTTGAC CTGCTCCCAT GATTCATGGG TATTCTTAAT GGCATCTAGA ATGGTGAACG TTTTCAGAAG GTTTTCAGTT GGCTTTGCCC GGATCCATCA GACGAATCCC TATCTATGGA AGCTATAGAT TTATAAAATG TATTTCTTTT TTTGTGGGGG CATAGCGTCT CACCCTGTCA CCCAACCTGG AATGCAGTGG CACAGTCATA ACTCACTGAA GACTCAAACT CCTGGGCTCA AGTGATTCTT CCACCTTGGC CTCCCAAAAC ACTGGATTAC AAGCTTGAGC CACTGTGTCT AGCCCAAAAT GTATATCATA ACTAATGAGG CTTGAAAGTC AAAGTGACTC CTTGATCCAT GGGCTACAGA ATGGACGCTG GGTTACCAGA CATGAAAACA ATACTCATCT CCTCATACAT CTCCTTCAGA GCTCCTGGGT GAGCAGGCCC ATTGTCAAAT GAGCAGTAGT ATCTTGAAAG AAATTTTTTT TCTGAGCAGT AGATCTCCAC AGTGGACTTA AAATAGTCAG TAAACTATGC TGTAAACAGA AGTGCTGTCA TCCAAGCTCT GTTTTTCCAC TGATAGGGCA AAAGCAGAGT AGATTTGGCA TAATTCTCTA GGGCCTTAGG ATTTTTGGAA TGGCAAATTG AGCATTGGCT TCAACTTTTT TTTTTTTTTT TTTTTTTGAG ACAGAGTCTT GGTCTGTCAC CCAGGCTGGA GTGCAGTGGT GCAATCTCGG CCCACTGCAA GCTCTGCCTC CTAGGTTCAC ACCATTCTCC TGCCTCTGCC TCCTGAGTAG CTGGGACTAC AGGCACCCGC CACCATGCCC GGCTAATTTT TTGTATTTTA GTACAGACGG GGTTTCGCCA TGTTAGCCAG GATGGTCTCG ATCTCCTGAC CTCGTGATCC ACCCGCCTCG GCCTCCCAAA GTGCTGGGAT TACAGGCGTG AGCCACAGCG CCCAGCCTGT CTTCAACTTA AAGTCGCCAG CTGTGTTAGC CTCTAATAAG AGAGTCTGCC TGTCCTTTCA AGCTTTGAAG CCAGGCATCA TTCTCTTCTC TAGCTATGAA AATCTTAGAT AGCATCTTCT CCCAATAGGA AGCCATTTTT TATGCCCTAA AAATCTGTCG TTTGGTGTAG CCACCTTCAT CATTGATCTT ACCTAGATCC GCTGGATAAC TTACCACAGT GTCTACATCA TTACTTCTGC TTCACCTTGC ACTTTTATGT TATGGGGATG GCTCCTTTCC TCTAACCTCA TAAACTAACC TCCACTAGCC TCACATTCTT CTTTTACAGC TTCCTCGCCT CTCTCAGAGT TCACAGAATT GAAGAATGTT GGGCCTTGGA TTACACTTTG GTTTAAGGGA ATGCTGTGGC TGGTTTGATT TTCTATCCAG AACACTAAAA CTTTCTTCAT ATCAGCAATA AGACTGTTTC ACTTTCTTAC TATTTTTTGT GATAGCACTT TTCCTTTCCT TCAAGAATTT TTCCTTTCTA TTCACAATTT GACCGTTTGA TATGAGAGGC CTAGATTTTA GCCAATCTCA GTTTACACCA TGCCTTTTTC ACTAAGCTTC ATCATTTTAG CTTTTTATTT AAAGTAAGAT GTGTGACCCT TCCTTTCATT TGAACACTTA CATGATGATG CCTGGCTTCA AAGCTTGAAA GGACAGGCAG ACTCTCTTAT TAGGGGCTAA CACAGCTGGC GACTTTTAAG TTGAAGCCAA TGCTCAATTT GCCATTAGAA GCCATTGTAG GGTTAATTAA TTTGCCTAAT TTTAATATTA TGGTGTCTCA GGGAATAAGG AGGCCTGAGT AGAGGGAGGG AGATGGGGAA ACAGCCAGTC ATCAGAGCAC ACACAACATT TATCAATTAA GTTTATCACC TTGAGGGCAC AGGTCATGAT ACTTCAAAAC AATTACAATA ATAAAATAAA AAATCATTGA TCGCAGATCA CCATAACAGA TATAATGATA ATGAAAAATT TGAAGTATTG TGAGAATTAC CAAAACGTGA CACACAGACA CAAAGTGAGC ACATGTCATT GGAAAAGTGG TGCTGATAGA CTTACTTCAT GCAGGGTTGC CACAAATACT CAATCTGTAA AAAATTCAAT TATCTACATA GTACCATAAA AACAAGGTAT ACCTGTTTAT ATAATCAAGA CCAACAGAAC CCTAGAGAAA ATAGCTCACT CCCTAGCTCG GAGACATTCT AACCAACATA CACTTACCTT TCTTTTTGCT GTGTACAGAA TTCAAATCCC TGTCTCAGCA AAATTGCAAA GTATCAAATG TCATGTCCAT CTAATACTCA AAACTGCAAA TGTTAAGTCT TGTAAGCCCA GAGACCACTG TATATACAAG TGTTGCTATA AGCATTAGTT CTTCTCCAAA GAAAATAGTC CACTTGGTAG AAACAAACAA AAAGAAAAAA AAAGAAAGAA AAAACATTTT TTACAAGAAG ATTCAGTCTC TTACCTACAT AAGCAAAAAT ATGAGATGTT CTCTTATCAT TTTTCCATCT ATCTTATAAT CTTTGGTGCT GACTTAGACA CTCATTTTCC TTTTTGTACG TGACCATGTA AAAGTTCAAG TCAAGAAAAA CTTGTTTTGA CATTTGTTTT GCTGAGTGAT GGGTCCCTAA AAGAAATTTG GCTTTGCTTT TGAAAAGTTC AGCATGATAT TGTGTGAATT TTTCATGGCT AATGATTTTT AGAACAGTTG TGATGTGTTT AGGTGTTTTA AGAATATGAA GCATTCAGTG GTTTAAGTTG GTTGTTATAA AATGAAAGAA TATGAAGGAA AGCCTTCTTG TCTTAGAACA CACTGATTCA CAAATAAGCA GCTTCTCTCA AAATGTTGTA ATTACAAAAA TTCCAAGGCA AATATAATAA ACTCCTTGTC GGTGCTATGT CTAGAAACTT AACAGCCCCA AAGAAAGTCC TGACAAGGCA AAAAATATAT AT AT AT AT AC AAATTGTGGA AGCAGGGTGT TGAAAGAAGA ATAAAGACTA TATAAGGACA AACTGTTTAA AAGGGAGGGT ATCCTTGAAA GCTTGACACT TGACTCTTTT GACGAGGCTG AGGGAAAACA CTCAGTTTCA TAGATTGCTG GTACGGATGT AAAATAGTGA CATCCCTATA GAGAGGAATT TGGCAATATC TAGCAAAAGT GCTTATGCAT TTATTCTTTG ACCTAGTAAT CCCGCTTCTA GGATTAGTGG TGAAGATACA CCTCAACAAT AAAAATATAT ATACATTAGG TTATTAGTTA TGGTTTAATT TTTAATAGCA AAATATTTAA AACAACCTAC ATGAACAAAT AGGAGACTTA CTGAATAAAC TATGGTATAT CTGTACAATA AAGTGCAATT CACTTATGTT GTTAATTTGT TCCAAAAATC CAGAGCCAAA GAGTATTTGT TATGCTCTCT TTAGTATAAG AAAGGGGAAA TAAGATATGT GTGCATCTGT TTATTTTTGT GAAAATAAGT ACAGAAAGGA TAAGTAAGAA ACTAGTAAAA CTAGTTATCT CCTAGTGTTA GTAGAAATAG AATGAAAGTG AATTAGGCTT CTTTGAGTAT ATGTTTATAT ATAGTTTTGA CTTTTGAATT ATGTTTATGT TTACATAGTC AAAAATATAA ATTAATCAAC AGAAATAACA AAAAAAGAAG AAATCACAAG CTTTAAAATT TAATACAAAC AGAAATAATT GAATCTAACA GTATATCAAA GTGATAACGT AAACTCAGAA GAAAAAAACA TAATCCAACA TACCAGTGGA ACACAATATT CTAACTGTAT ACATTCAGTG GTTATAGTCT AAGGACAAGA AAAATTGCAA AAATATCTTG AACTTTAGCT TGTAGGATTT TTATTGGTAG CAATACTAAT GTACTAATTC TGAAATTAAT GTTCGTGTAT TATAGAATTG AGTAAATGAA TAAATATGTT GATGTTATTG GGAACTAAAA EPI-109 138

TTATCATTCT GGGAGTAGAG AAATATAAAT ATGGACTTGG CAAATGAAAC AAAGACCTGC AGAGAGATAA CCATATAAAC TCATTATTTT AAAAATTATA AGTGTCCTAG CTCTGTTACT GAAAAGGCCT AGATTCAATC TTATCTTGAT AGACAGGAGG GCACCCCTTT CTCAGAACAT GGTTTCCAAA TGCCATTCTC CATTAAAAGG AACAAGGTCT TCTTGGAGAA AAGACTGATT CTAGGTCTGG ATTAGGTAAA GTACAACGTT AGTCTGGAAT TTCTTGCTGA ATCAGAAGTA AGAAAGTGCT CAAAAACATG GGAACATGTC ACAAACACAC GTGAGGCAAC TTGAATCCTC ACTGGCCATA TTTAGGACAA TCGAGCATCA AAAAAAAAAA AAATGTTGAG AATAATGGAT TCTAACACTT AAAACAAAAA ATAATCCATA GCCCACAGAA GGGGAAGAGA GGGGGAGCTC TTATTTACAG ATGAATATCA AATAGCAAAG ACAGAAGAAA TGACAGAATT AGAGAAACAT CATTTTGCAA AACACCACTG TAATAATCAA TTCAGGCAAG TATTATTAAT GGATGTATTA CTATTGCGTA AAACCAGTTG GGGAACAGGA TATTCATACA GTCTGAAGGT GTCACCCTAA ACATAACTTA TTACAAGTGG AAAATGGTGC CTTTACAATG AAGAAATCTA GCAGAAACCA TCTTAATCTA GTGATCAAAC TTAGTATCAC CAATAATGGA TCATACTGAG TCATGTGTCT CCTAATATGA TGCACCAGGA AGGATGCAAC GTCATGAACG TTGTATTCTT TTGTATTCAA CAGACCACCC AGGGTAAAGG CAGCTTTCTC ACTTACTAAT CAGAATTGTT GGTTTTAATT CATTTTGGAT TTTAAGATTT CTTACTTTCT TGTCAGCTCA GAAATTTATT TAAGATGATT TTTATCTTTT ATTCAATACT TTAGCTTGGA GAACCATTCA GAGTTTCTAA CTCATTGTAT TGCCAAAAAT AGAAAACAGC ATGGTTTCTT TTGAAAATGT CTAACTTTAA AGTTACTTGT GTGTGTCACT CAGATTCACA TAGCTTTTTT GCCTAGTAAT GTAGTATCAT GTGGCAAGGC TATAAAAATG TTTACAATCT TTTATTTAAT ATGACTCTTG AGAGTTTATT CTAAGGAAAT AATTGAATAG TAACAAAACA CTATTAACAC AAAGCATAGC AATTTGATTT GGGCAACCAA ACACTGGAAA CAACCTAAAT GTCCATTACA GGAATCATTT ATGAAGCAAA CACTAAAATA TTTATTGTGA AGATTATGAG AACATAGAAG ACAGTTATGA GAGTAAATTT GAAAACCTGA ACACAAAACT TACATATACT CCAATTGTAA CTTATAAAAA ATACGTGCAT ATAAGGATAA AACAGTACAA ACAAAAAAAT AGTTGCGTTA GATTGGTAGA ATTATGGCTC CTTTTGCTGT CTTAATTTTT TCCTTTTACA TTTTGATACA TTATTTTAAT TTTAATTTTA AAATTCAAAA GAATTTGCCA CTCATCTTTG CCACTTCAAG GAAAAAAGAA ATGTGTTCGA TTATTCTGTT CTTAGTATAG TTTTGGCAAT TTCCTCACGT GTAAAAAGAG AATACTATTA ATAATTTCAG TATCTATAAG ACAATATAAA ATTAAAGAAT CTAGCCCAGT AACTGGTACA TGGAACGTAA TTAATAAATC ATTATGGACT TTTTTTCTCA CACCCAAGTA GGGAGGAATC AGTGGTCCCC TAGAGGCCCA GTGTAGAGGT GGCAGCACCA ATCCCTAGGG GAGAAGATCT TGGTGATGAT AATTCCTGAG CAGACAGTTA GCTGAGAATT CAAGAGCAGA AAAGTAAGAA AGAAACAACT TCTTGCTAAC ACCTTTCCAC CCACGTTTCC CTGTTCTGTT GTACTCTGCT TACCCTTTCA TGGATGGAGG CAGAGGAAAG AGAACCAAGT TTGCTCTTAG TCATTCACTA TGTTGTTTAA TCTGCCTTCC ATCTTTCTTA TCAGTTCAAA TTAGAATGTA GACCTGAATT TAAATCCCCG TTCTGTCAGT TATAATGTGA CCCTAGACAA AACACATTCT CTGAACCTCA GAGAACATTC TTCATTTGTA GAATGGGAAG ATTAATCTAT ATTCCACTTG GATGGCAAGT CTTTTATAAA CTTTATAACC TAAACATGTG TGAGTTGCTA GTATCATTAT GTTGGTAAAG TTATTCTGAG ATATGATAAC AGAACTGTTT TGTCTAACTC CACTAGCATG GTTCAGGTTT AGAGAGTGTG GAATTAAAAG GCTTTATCCT CAAATATGAC TTAAATCCGA TTTTTCTCAT CCACTTTCCT CCACAAACAA ATCCTCAGGA AATGACAAAC TTTACATGGT TAAACATCAG TTTTGTTTAG TCTTTGACAT CCACATGGTT AAATCATACA TTTGAAAACT GCTTATATTT GTGTTGTCTA TGTCTAAATT GAAAAGACTT ATTGAGGAAT AGAAGACTAC ACATTTTTCA GCAAACACTG CACGTTTTGC AGAATTTCCC CAGGCACCAG TCTCCAGGAA TTTATTGGCT ACTAACAATA CTAAGATATG GATGAATGAG GAAATCAAAA TGGAGATCTT GCAAGTTTTG TGAGAATGGG TGAATGGTCC AAATGAAGAG ATAAGTTGTG AAATATTAGT ACAAGTAAAA ATTATTTACA ATGAAAGACA TTTTGTCAAT AGCTATGAGA ATTTTACCAT TGACCCAGAA ATTCCATTTC TTTCTTCAGA AATACCCACG TAGGTATACA TATAAAAAGT TATTCATTAC AGTATCGTTT TTCATAGGAA AAAGTTTTAA AAATCAGAAG CTATCTAAAC TATGGTATAT CTAGGTCATA GAAATCAAAT GACTAAAAAT GTTAATATAA GCATATGTTT TTAAATTAAC TTGGCTTGGG TCTTCAGCAA AATTGGCTTC TTAACATTGC ACTCCAGAGT TAGACTTACC CACTCAGTCA CTTATCATGC AGGAGCAGAC TCCTAATACC ACATATCATA GAGCAGAGTA GGACACAGGT TCTCTGCAGG CAGGCAAATC CCAAAGAGAA GGGAGGAAAG GGCTGAGACA CTGCATGGTC AATTTCTTCT GAACTCTGCA ATGTACGGAG GTGGACAGTG TCCACAAAGA TTGCTCCCCT GGACCCACCA TCATAATAAC ACAACGGCTT TGTTTTGTTT TTGTTTTTGT TTTTTGACAC GGAGTTTTGC TCTTGTTGTC CAGGCTGGAG TGCAATGGTG TGATCTCGAC TCACCACAAC CTCCACTTCC TGGGTTCAAG TGATTCTCCT GCCTCAGCCT CCTGAGTGGA TGGGATTACA GGCATGCACC ACCATGCCCA GCTAATTTTG TATTTTTAGT AGAGACGAGG TTTCTCCACG TTGGCCAGGC TGGTCTCAAA CTCTTAACCT CAGGTGATCC ACCCGTCTTG GCCTCCCAAA GTGCTGCGAT TACAGGTGTG AGCCACCGCG CCCAGCCCAC AATGGCCTTT TGTTTACATC TCTAGTGCAG CACTCATTTC ATGTTCTTTC AAGAAGAATA CATATTTCAT CTTTTTATTT TATACAGCAA TTAGCACAGT GCCTGGCATA AGGAAAATGA TCATTAAAAG CTGGGTGAAA AACCTAATAA AGCTACTGAG GATAGGAACT GCAGACCAGC ATGGAAAGAA AACTATGAGC CAGATATTGA CATCATCCTG AAAGGCAGAA GATTTAGTAT AGGCAAGAAG TATGCTTTTG GAATATAGAA AATCTGGATT ATGATAAGAA AAGAATCATA TTTGTCTTAT CTTACCTACT CACTTCTCAG TTCCACATGT TTCTGAGGCT GTTTGTCCTT ACTTTCTTTT CTGTTTTATC CACTCTTTCT GTTCTTTAGA TTGGATCATT CCTATTGAGC TGACATCAAG TTAACTGACC TTTTATTTTG TCCAAACTGC TGTTAAATGC ATCCAGTGAA TTTTTAACTT TATATAGTAT ATCTTTTAGT CCTAGAATTT CCACATGAGT TTTTTAAGTT TCCATTTCTC TGCTGAGATC TCCTATTTGT TCATTCATTA TGACCATATT TTTCTCTACA TTATTGAGCA TAATTATAAC AGCTCTTCTA AAATTCTTGT CTGCACATTC TAACACCTGA ATTATTCTGG GGTCAGTCTC TGTTACATTG CCTTATTACA AAAACAGTAT AAGTCACATT GCCTTGTTTC TTAATATGCA AAATGATTTT TGATTGCAGA CTAGACATTT TGAATTAAAC ATTATAGAGA TTCTGGATTC TCGAGAGAGT ATTGACTTGT TTTTTCCATC AGGCAGGTAA CTTGACTGGA CTCAAACTCC AAACTCTAGG TCCTCTGTAA TGGGCAACTG CAGTAATCTT TGTTTAGTTC TTTAAGACTT ATTGGCCAGG CACGGGGGCT CATGCCTGCA ATCCCAGCAC TGTGGGAGGC CAAGGTGGGA GGATCACCTG AGGTCAGGAG TTCGAGACCA GCCTGGCCCA CATGGTGAAA CCCTGCCTCT ACTAAAAATA CAAAAATTAG CCGGGTGTGG TGGTGGGCGC CTGTAGTCCC AGCTACTCAG AAGGCTAAGG CAGAAGAATC ACTTGAACCT GGAAGGCAGA GGTTGCAGTG AGCCGAGATT GTGCCACTAT ACTCCAGCCT GGGTGACAAA AGCGAGACTC CCTCTCAAAA AAAAATTTAT TGGCACTGCT TGGCATCTGC TATGAATACA TGAAGTTCAT GGGTCAGCTA TAGATCTGGG CACGTTATAC ACAGAATTTG GGTCTCCCTT TCTCTGGATT TCTCCTTTTC TGGATTTCTT TTCTCATTTT CCAGCAGCTG TGGTTGCCCT AAACTCGGTC CTCTGTTTCT TTACGGCAGT AAGATTTGGG AACTTTTAGG TTTTACCTGC CTCTCAGACA AAATAAAAAA TAATTTTCAT CTTGATGCTA CTCCTTTCTT CCAGATGTAG ACACCTCTCT AATTTCCAGT TGCTTTTTAT TGCTCTCCAG AGTCTAAAGA TTATCATTGT TTTCTGTGGG AGAGTTGGTC TGATAAAAAC TACTCCCCCA AAACTGGAAG CTGGAAGCTT GTAATTATGA ATAGACTTTG AGTAGTATTC TTCTTTGGAA AAGGATTTTA ACTACTCCCT ATGTACTTCT TTATTTCCTG TTTTTCTCAT CCGTAATCTT TTTATTTTCA TACTTCCTAA GTCAGACAAT TTTCCTACTT GAAGATTCAG TGACTGCTAT CAAATGACCC CCATATTACT AAATACAATA TCCCCAACTG CATTTATAAA AAGAAAATTT ACTGTTTATT AGTAAACAAT GTTGTAGAAT AGTAAAATAT TGCTGGGCTT TGGAGCCAGA TAATCAAGGT TAGAATCCCA GATTCTAACT TACTAGCTGG TGTATTAGTC EPI-109 139

CTTTCTCATG CTGCTAATAA AGACATACCC CAGACTGGGA GACTGGGTAA TTTATGAAGA AAAGAGGTTT AATTGACTCA CAGTTCAGCA TGGCTGGGGA GGCCTTAGGA AACTTACAGT CATGGTGGCA GCAAGGAGAA GTTCCAAGCA AAGAGGGAAA AGCCCCTTAT AAAACCATCT GATCTTATGA GAACTCACTC ACTATCACGA GAACAGCATG AGGGTAACTG CCCTCACGTT TAATTACCTT CCACCAGTTC CCCCCCATGA CACATGGGGA TTATGAAAGC TATAATTCAA GATGAGATTT GGGTGGAGAA ATAGCCAAAC CATATAATTC CACCCCTGGC CCCTCTCAAA TCTCATGTCC TCACATTTCA AAACTCAATC ATGCCCTCCC AACTGTCCCC CAAGGTCTTA ACTCATTCCA GCATTAAGTC AAAAATCCAA GTTCAAAGTC TCATCTGAGA CAAGGCAAGT CCCTTCTGCC TATGAGCCTA TAAAATCAAA AGCATGTTAG TTACTTCCTA GATACAGTGG GGGTACAGGC GTTGGGTAAA TACACTGATT CCAAATGGGA GAAATTGCCA AAACAAAAGA GTTACAGACC CCATGCAAGT CCAAAACCCA ATAGGGCAGT CATTAACATT AAAGTTCCAA AATGATCTCC TTTGACTTCA TGTCTCACAT CCAGGTCACA CTGATGCAAG AGGTGGGCTT CCAATGGCCT TGGGCAGCTC TGCCCCTGTG GCTTTGCAGG GTATAGCCTG CTTCCTGTTT GCTTTTTCAC AGGCTGACAT TGAGTGTCTG TGGCTTTTCC ATGAGTATGG TGCAAGCTGT TGGTGGATTT ACCATTCTGG GGTCTGGGCC AGGTGCAGTG GCTCATGCCT GTAATCCCAG CACTTTGGGA GGCTGAGGTG GGGGATCACA AGGTCAGGAG ATCGAGACCA TCCTGGCTAA CACGGTAAAA CCCAGTCTCT GCTTAAAAAA TACAAAAAAT TAGCCAGGCG TGGTGGTGGG TGCCTGTAGT CCCAGATACT TGGGAGGCTG AGGCAGGAGA ATGGCGTGAA CCCAGGAGGT GGAGCTTGCA GCGAGCTGAG ATTGTGCCAC TGCACTCCAG CCTGGGCGAC AGAGCAAGAC TCCATCAAAA AAAAAAACAA AAAAACCATT CTGGGGTCTG GAGAATGGTA GCCCTTACAG CACCACCAGG CAGTGCCCCA GTGGGGACTC TGTGTGGGGG CTCTGACCCC ACATTTCCCT TCTGCACGGC CCTAGTAGAG GTTCTCCATG AGGGTTCTAC CCCTGCAGCA AACTTCTGCC TGGACATCCA GGCATTTCCA TACATCCTCG GAAATCTAAG CCGCGGAGGT TCCCAAACTT CAATTCTTGA CTCCTGTGCA CCCACAGGCT CAATACCACA TGTAAGCCAC CAATGCTTGG TCAGGGCTTG AACCCTCTGA AGCAATGGCC TGAGCTGTAC GTTGACACCT TTTAGCCTAG ACATCTAGGA CACAGGGCAC CATGACCCGA AGCTTCATAA AGTGGGAGGG CCTTGGGACT AGCTGAGGAA ACCATTTTTC CATCCTAGGC CTCCAGGCCT GTGATGGGAA GGGCAGCCAT GAAGGTGCCT GACATGCCCT GGAGACGTTT TCCCCATTGT CTTGGTAACT AACATTCAGC TCCGTGTGCA GCACCAACTT ACTTATGCAA ATTTCTGTCA CTGGTTTGAA TTTCTCCCCA GAAAACAGGA TTTTTCTTTT CTATTGCATC ATCATGCTGC AAATTTTCAA ACTTTTATGC TATGCTTCCT GTTGAAGACT TTGCGGCTTA GAAATTTCTT CCCCCAGATA CCCAAAATTA TCTCTCTCAA GTTCAAAGTT CCACAGATAT CTAGGGGACA AAATGTTGCC AGTCTCTTTG CATAGCAAGA GTGACCTTTA CTCCAGTTCC CAACAAGTTT CTCATCTCCA TATGAGACCA TCTCAGCTTG GACTTAGTTG TCCATGTTAC TATCAACATT TTGGTCAAAG CCATTCAACA AGTCTCTATG AAGTTTCAAA CTTCCCCATG TTTTCCTGTC TTCTAATAGC CCTCCAAATT TTTCCAACCT CTGTCTGTTA CCCAGTTCTA AAGTCACTTC TACATTTTTG GGTATCTTTA CAGCAGTGGC ACTCCCCATG GTACTAATTT ACTGTATTAG TCTGTTCTCA TGCTGCTAAT AAAGACTTAC TCGAGACTGG GTAATTTATA AAGAACAGAG GTTCAACTGG CTCACAGTTC AGCATGGCTG GGAGGCCTCA GGAAACTTAC AAACATGGTG GCAGCAAAGA GAAGTTCCAA GCAAAGAGGG AAAAGCCCCT TATAAAACCA TCAGATCTTG TGAGAATTCA CTATCATGAA AATAGCATGA GGGTAACTGC CCCCATGATT AATTTACCTC CCACAGGGTC CCTCCCATGA CAGGTGGGGA TTATGGGAAC TACAATTCAA GATGAGATTT GGGTGGGGAC ACAGCCATAC CATGCCAGCT AGAGAGCCTT AAGAAAGTCA CCTAATCTCC ACAAATAAAA GGTTTCCTAT TTGTTCAACA AAAATAATGA CACCCCTTTT ATGGGATTTC TGTGAGGACA AATGATAACT AACATAGCCT TGCATAGTGT CTGGCACAAA ATAGCTACTC AAAAAATAAT AGAAACAACA TTTAAAAAAT GTAGACTTTA TTTTTTAGAG TTTTATGTAC AAAGCAAAAT TGAGCAGAAT GTACAGAGAG TTTCCGTATA GCACTCCCTA CCCCCAAGCA CAGATAGCCT CCCCCAGTAT CAGCATCCCG CACCAGAGTG GTACATTTAT TATAACTGAT GAATCTATAT TGACGTGTCA TTTTCATCCA AAATCCATAG TTTATATTAG GGATGCCTCT TGGTGTTGTA CCTTCTATGG GTTTTGACAA ATGTATAATG ACATGTATTC ACCATTACAG TATCATAAAG AATAGTTTCA CTGTCCTAAA AATCTTTGAT CTTCTTCCTA TTCATCACTC CCTCCCCATT AATCCCTGAC AACTACTGCT AATTTTCCTG TCTCCATTGT TTTGTCTTTT CCTGAATGTC ATATAGTTTA AATATACAGT ATGTAGGATT TTCAAACTGG TTTATTTCAC TTAGTAATAT GCATTTGATG TTCTTCCATA TCTTTTCAAA GCTTCATAGT TCAATATTTA TAGAATTGAA TAATATTCCA TTGTCTGGAT GTACTACAGT TTATGTATTC ATTCACCTAT CAAAGAACAC CTTGGTTGCT TCCAAGTTTC AACAATCATG AGTAAAGCTG CTATAAACAT CTATGTACAT GTTTTTTTGT GAATTGAACA TTTTCAGCTT TTTTAGCTCC ATTCCTAGGA GTGCAATTGC TGGATTGTAT GATAAGGGTA TGTTTAGTGT TGTAAGAAAC TGCCACGCTC TTCCTAACTG GATGTACTGT TTTGCATTCT CACCAGCAAT GAAAGAGTTC CTGTTGCTCC ACATACTCAC CAGCATTTGG TGTCGTCAAT GTTTTGAGCA ATAGCATTTT GATCTAACTT TTCCTAGGTA TTCTTTTTGA AGGAAATAAT ATGACAGATA ATAGAGAAAG GATATACGAG GACAGTTCTG TCCTTTATTT ATAGTCCATC ATTTAATGAA GGACTCTGTC CACACTTGGT ATTTTTAACT CTGATCCTCC TCTCCCATGA ACTCTGACAA TCTCCTAAAT CCCTGTTGCT GGCACACATG GTTGTGTATC AGGCCCCCTG TGGTCTGTCT GAAGCATGGC TTTTTTTTTT TTTTTTTTTT TTTTTTTGAG ACGGAGTCTC GCTCTGTCGC CCAGGCTGGA GTGCAGTGGC GCGATCTCGG CTCACTGCAA GCTCCGCCTC CCGGGTTCAC GCCATTCTCC TGCCTCAGCC TCCCGAGTAG CTGGGACTAC AGGCGCCCGC CACCACGCCT GGCTAATTTT TTGTATTTTT AGTAGAGGCG GGGTTTCACT GTGTTAGCCA GGATGGTCTC GATCTCCTGA CCTTGTGATC CGCCCGCCTC TGCCTCCCAA AGTGCTGGGA TTACAGGCGT GAGCCACCGC GCCCGGCCTT TTTTTTTTTT TTTTTTTTTT TTTGAGATGG AGTCTGTCAC TCTGTCACCC AGGCTGGTGC AGTGATGCAA TCTTGGCTCA CTACAACCTC CATCTTTCAG GTTCAAGTGA TTCTGCCACC TCAGCCTCCC AAGTACCTGG GATTACAGGT GCCCGCCACC ACACCCAGCT ATTTTTTTGT ATTTTTAGTA GAGACGTAGT TTCACCATGT TGGCCAGGCT GGTCTCATTC CTGACCTTGA GTGATCCACC TGCCTTGGCC TCCCAAAGTG CTGGGATTAC AGGCATGGGT CATCACATGT GGCCTGAAGC ATGACTGTTG CTTTAATCAT ATGAAATACT GCTCTGTATT GTTATCTATT TGAAATGCCA CACCTCCTGA GCTAAATTGC AAGCTTTTAT GGAGCACAAA CCATATTTAT ATATATTAGC ATGATACCAT GACACATATC AAAAGCTGTT ATATATTGTT ACGTGAATTG ATTCTTTCTC AGTTAAGAGG ACCTCTGTAG TAGCACTTTC ATACCGTTAA TTTTTCATTT TGTGCCCAGC CCCTACTCTG TGAAAAATGA AATGAATCCT GTTATCATTT CCCTCCCAGG CCTTTTCTCC TTGTGGACAA TGTGTGGCTC AAGAGAAAAT TCAGTCAGTA AATTTGTTCA GTGCACAAAC TCTTTATCAC CTCTCACTGT TCTCAAGTGA GATAGAACAG AACATCCATC CAGTGTCTTA CAAATTGTCT GGTATATAGT AGGCACTCAA TAAATGTTTT TTGAATAAAT GCATACATGA ATCCTATTCC TATATATAGT ATGGTAGACA GATCATTGAT ACCCAAAGAT GCCCAAATGC TGATCCCCAG AACTTGTGAA TATGTTACAT TTCATGTCAA AAGGGACTTT GCTAATGTGA TTAAGGATTC AGACCCTTGG ATTGTAAGAT TATCCCGGAT TAACCAGGGC CAATCTAATC ACATGAGACC TTAAAAAAGC AGAAAACATT TCCCAGCTGG GTTAGAGAGA GATGAGACAG AGTAAAAAGG AAAGAGATTC AGGGCATGAA AATGACTCTA CCCACTGTTG CTGGCTTTGA AGATAGAGGA ACTAGGCCAC AAAACAAGGA GTATGAGTGG CCTTAAGAAA TAGGAAAAAG CCCTCATCTG ACAGCCAGCT AGAAAGCAGT CCTCTGACCA CAAGAAATTG GATTCTGCCA ACCACTCAAA TGAGCAAGGA AATGGATTCT CCCCTAGAAC CTCCAGAAAG GAACACAGCT CTGTAATGCC TTGATTTTAG CCAGGTGAGA CCTGTTTCAG ACTTTTGACC TATGGAAATA TAAGATAATA AAGTTTTATT GTATGCTGCT AAATTTGCGG TAGTTTATTA CTGAAGCAAT GGAAAGCCAA bPI-109 140

TACAGACAGA ATATACAGAG AGAAAGAGAA TGAGTTCTTT CCTGATAATT TGTAAATATT TGGGTCTTCA CTGGACAAGC TTCACAGAGG ATTCACTGGT TCCCTAGCAA ACCAGCATGT CCAGTCCTGC AGCCTCCCTT TCTTAGGCCC AGCATATGTC AGCTGTGTGC ATAGAAAAAT CAAAGCAGGA CCCTGAGTAG TTGGAAAGAA AAGATGGTTG GAAATGGGTT GCACTTCAAG TGAGGAAACA AGAGGTAGGA GACCGGCATC TCTTTCTCAT ATGTCCCAGG CTGACTCTTG TGAGTTGTTT TCCCTTGGAG GCTATCGATG ACAGTCACAG TAACCTGATG GAACCTGGAT CATGATGAAA GAAGTAAGTG TCAATGGCTC CGACTTCCAA GGACTCTGAT GTCCCACAGC ACTAGCTAAA CAAAGCCAGT TGGAAATGAG CTTAAATGGG GAATTTCCTG AATATATTCC CTATTGTTAG GAAGCCAGGT TGGCTTCCTT GCCTACAATT ATGCCAAGCA GTCACACTAT AGAGTCCCTA GGGACATGAT ATTAAGTGAT TCTTTTAACA CAAACAACTT AATAATCATT TATACTAATA GCAAAACGGC CAACGGCTGA TATTCCACTT GAAGTAGAAT TGGCTATCCA ACTGGAAGAG AAGACAGGAA GACGTGATCT CCAGGGAGCC ACTAAAAGGA TTGGCACCTG CCTCTGGATT CCCCTTTTCC TTATATTACC TCTCAGCACT GGCAGGCCTT TATTTCAGGA TACAGTTTCA CAAGTATTAT GTCACGTCTC TGAGAATTAT GTTGGTAGAT ATTTGCTCCT CTGGCCAGAA AGACCTAGTT TGGAGTCTGG AGTCATGAAG GTGACATACA TGTAGCTAGT GACATAAGTG TAGCTAGTAA AAATAGTGAG TAATGGCCCT GAAATTCTAT TGAATGCCCA AAGTGCTGAC CAGGAACAAG CATGCTCTAG CTTATCTCAC AAGGAACTTG ACAATTTTCT TCAAAAATCC TAGTAGCTAA GATTTCTTAG TAACAAAGCC ACTAAGGCAC AATTATGATT AACTTGACCC TTAGGTGACT TTTAAGGACT ATTCTATAAA ATATTACAAC TAATAGTGGA TCCAAGCCAG CACACTCTGC TATATAAGAT TAATTGACAG TGTCCACACT GGTAAAATAA GTTGTTTCAT AAATACATTA GAATTCATTT GCACTTTCTA CACAGCCCCA AGTCCAGAAC TTTCCCCAGA ATAGGTCTAT GTTTTGCAAT CTGCTACTCC ATACAGAGAT TTGAGTTCAC TTGGCAATTT AGTGCTGCTT ATATGTGACC AGTTAGTCTG TTTTACTTAT CTATGCCTTA AACATTACTA TACTTACTAA CTCCAAGATG CCTGGTCTCA ACTTGACAAA AATACCCCAA GTTGGGAAAT CCTTATGTGA ATATGTAGAT AGTCACAATT GCTGGTTGAT GATGATCTGT CTTTTCCTGT ATTTGAGAAA ATGGAGATAA AATGGACCAA TCCAAATAAT GGATTAAACA TGGGAATAGG TGAGAGAGAG AGAGGAATAC ATGGTGGCTC TCAGTGTCTG GCTTAGGCAG TAAACACTTT CGTTAATAAA GACGGAAAAT AAAAAAGGAA TAATTGGTGT CTAGGGGAAA ATAATGAGCT CAAGTTTTAA CACTCTGAGT TCCCGGATGT GAGACATCCA GGCGCATTTA TCCAAGAGGC AGTTGGAAGC AACGTTCCGG AGCTTAGGAG AGAGGCATGA CCAAAAGCTG GTGGGACTGT GAAAAGGTAT GGCCATTCTG GAAAACTGTT TGGCAGTTTC TTAGAAAATT AAACATGTAC TAACAACCCA GCAATTGTAC TCTTGAGCAT TTGTCCCAGA TAAATGAAAA AAAAAAAAAG CATTTTTTTT ACACAAAAAC ATATACATGA AAGTTCATAG AAGTGTTATT CATAAAAAAC TGGAAAAAAC TGAGATGTCT TTATTGAGTG AATGCTTAGG CAAACGGTGG TCTATCCATA CAATGGAATT ATGCTTAGCA ATAAAGAGAA AAGAACTATT GATACATGCA ATAACACAGA TGAATCTCAA AGGAATTAAT GCTGAGTGGG AAAAAAAGCA CATCTCAAAA TGGTATATAC TGTACTATTT TATTTACTTA ACATTTTAAA AATAGCAAAA TCATAGAGAT GGAGAACAGA TTAATGGGTA CTGTGTTTTG GGATGGGGAG TGAGAAAAGG GTAAGGTGTA AATATAAAGG GGTAGCACAA AAGAGCCTTG TGGTTGAAGG ATTCTATGTC TTGGTTGTAG TCGTGATTGC AGGAATCTAC ATGTGATAAA ATTGTATGGG TCTACATACG CATACACACA AGAGCATATA AAACTGGTGA CATGTGAAGA AGCTCCGCAC ATTGTGCCAA CATCAGTATC CTAGTTTCAA TATCAGACTA CAGTTATACA AAACATTGTC ATTGAGGGAA ACTGGGTAAA GGGAACACAG GACATTTGGC ATATATTTTT GCAATTTCCT GTGAATCCGT AATTATTTAA AAATAACAGA TATACTACAT ATCAAAAATT TAATGTCATA AAGTTGATGA GTTTACCTAG TGGATAGCTT TGTTAATATC TGCTATAAGA CTACTGAAAA TGACAGTTAT GCAAGTATAA GCTCAGAGAA CTTTCCTCCC CCTTCGTAAA TGAAATGAGC AAAAGAAATG AAACAGGAAA GGCAAGCAGT ACTGAAAACA GGGAAGGGCT CTTCCCCATA TAACTATATC TGCGACTTCA ACAGCTATTC ATCCAGAAAC ACAGCCTCTT GCGCTAAGAG GAAACTTTGG ATAACAATAT GTTTTCACTC TCCAAGAGAG AAAATGGATA GATTAATTTT TAAGAAAAAA AAAAAAACCT CACCAATTTC ATGCTGTGGC TTGCACCTTT AATCCCAGCT ACCTACAAGG CTGAGGTGAG AGGCTTACTT GAGCCCAGGA GTTCAAGGCT GCAATGAGCT ATGATTGATT GTGCTATCGC ACTCCAACCT GGAGTACTAA GCTAAGAGCT AAGAACACAG CTGAGAGCGG AGAAGAAACA AACAAATCTG ACCAATAACC CCCACTCCCC TCATTTTACT GGAGTGAGCT GAGACTGCTG GCAAACATGG CCTTTGACCT AGCCTGAACT GTAGCAAAAG TCATCAGATA TTTTTCCACC AATCAACAGA CAGAAGTGGG GAGAAAACAA TCGTAGTTCA TAACTACAAC AAGCAGATAA ACGAAGGCCA TGGTGAGGGA TGGAAGACAT TGTGATATAT CAAAGGCAGG CTCATTTAAA ACTCAACCCA AATTCCAAAC AAAATATATA ATTGAATATG TATTAATGCC AAAGGAGCTT GAGTGAGCTT TAGCACAAAC CCCGCCCTCC AGCCCCCACC CAAAAAAATC ACTCTGTTCT CTCCCCATTC TTTGATAGGC ATACTTGCTG TTTTCTCACA GCCAAGGTAC AGAGGGGACT TAGAGGAACT AGAACTCTAA TACACTGCTA GCAGGAATGT AAAATGAAGC ATCTACTTCA GAAAACCATT TTATCAGTTT CTAGAAAGTT AAACATAGAC CCACCATGCA GCCCAGCCAC TCTACTCCTA AGTATTTACA CAAGAGAAAT GAAAACGTGT CCCCACACAG TTGTATTTAA AGGTGATGGT TAGCCTTGTG TGTCAACTTG GCTAGGCTAT AATACCCAGT TACTGAATCA AATAGTAATC TAGGTGCATC TGTGAAGGTA TTTTGTAGAT GTGGTTAACA GCTACAATCT GTTGACTTCA AGTAAAGGAG ATTGCTCTTG ATAGTATGGG TGGGCTTCAT CCAATCAATT GAAGGCCTTA AGAGCAAAAA GTAAGGTTTC CCGGAGAGAA AGAAATTCTG CCTCAAGACT GCAGCCTCAA CTCCTGCCTG AGTTTCCAGT CAGCCAGCCA GCCTAAAGAT TTGCTAGGCA TTATAATCAC ATCAGCTAAT TTCTTAAAAT AAACCTCTTT ATATATATTG ATACAATGAA TGGTTATAGC AGCCTTATTT GTAATAGCCA CAAACTGGAA ACAACCTAAA TGTCCTTCAA TAAGTGAATA CATAAACAAA TTGTGGTATA TCCACAATTT TTACGCAGCA GTAAAAAGGA ATAAATGGTT GAATAAGGAA TAAACACATA ACAAGGATGA ACCTTAAAAC CGTAAGGCTG AATGGAAAAA GTCAGACAAA ACTAATACAT ACTGAATAAT TCCATTTATA TTGAAGTTCT AGAAAATGAG GACTAACCTA TAGTAACAAA AAGCAGAAAA ATTTTGCCCA CTGGTGATGG AGGGGGCGCA GGTATTGTAG AGTATCTGAG AAAGGACAAC TGGATAAAAG GGGGCACAAG AAAACTTTTG AGGGTGATTG ATATGTTCAT TATCTTGTGG CATGGTTTCA TAGGTGCATA CATATGTCAA AACATCAAGT TATACACTTT TAAAATGTTC AGTTTACTGT ATATCTATTA TACTTCAGTA GAGAGGAAGG AAGAAAGTGG GCAGGGTGGG GGAGAGGAAA GGAAACGAGG GAGGAAAGGC CCTAATAGGA AGGATTTTGG AGTTTAGATT TTAAAATGAT AAAGGATGTT TGACACTCTA GGCATATGAC GAATATAGGA TTATGAGTCC ACAAAAACCA CCAGGAAGTC ATGTATGTTT ATACTTTTAA GTGAAGGATC AGTGGATTAT CAACTCCCTA ATGCTTTGCC TCTCTATGAC TGGCTGCTGT CCTTCTCATC CCAATACTCC TTCCAAAGCC CCTTGCTTAA ATGTAAGCCT TCΠTCCTCC TTCAACACA TCCTGCATTC CGTGACAAAA TAAGTTTTCC TTAAACAGAA TGTACAGCAT ATTATTTGTA

CAATTAAAAA TTTTTGGCCA GGTGTGATGA CTCATGCCTG TAATCCCAGC AATTTGGGAG GCCGAGATGT GTGGATTACC TGAGGTCAGG AGTTCGAGAC CAGCCTGGCC AACATGGTGA AACCCTGTCT CTACTAAAAA TACAAAAATT AGCTGAGTGT AGTGTGGCAG GTACCTGTAA TCCCAGCTAC TCAGGAAGCT GAGGCAGGAG AATCGCTTGA ACCTGGGAGG TGGAGGTTGC TGTGAGCAGA GATCAGACTA TTGCATTCTA GGCTAGGAGA CAGAGTGAGA CTCGGTCCCC AAAAAAAAAC ACATTTTTTT TTAATGTTTC CTCCTTGCCT GTAGGAAAAA GGCTCTGACT CCTTAGCCTG GGCATCAGAG CTCTATCTAA ATGGACTTTA ACCTGATTTT GTGGCACTAA TTCCATTGCA GTACTTGTCC GCTCACTGGC CTGTGCCTCT CTGCCACTAT TTTTGGAATA ATGTCCTCTC TCCATCTTGT TTACTCAACT ATATCCAACC TCTAAGGCTG TGCTCCTACA AAGCCTCCCC TGGCTACTTC EPI-109 141

AGCCCACAGA GATATTTAAC TGCTCTGCAG TTCAGGACAT TCTTCTGACT CTTTAAATCA CATTTACTTA TATATGATCT TGTGATATTT TTTGTTGACG TGTTTACTTT AATTTTCTTC CATAACCTAT TCATTCAACA AACTCAACAA TTATTTATTA AATGCCAAGT TAGAAAAATA TTATTGATTT TATATAGATT ATAGATATGT TTGAAATTTT ATTTGGCAAT CTGCAAGTAG AAAAATAATT ATAATGTGGT ATATCTGTGA TAGAAGTATT AGTGCAGAGA CCATGGGGAA CATAATCCAG CCTGGAAGTT CAGGAGAGAT ACGTGGAAGA AAGGACGTCA GAGCCTTTTT CCTACAGGCA TGGAAGAAAC ATTAAAAAAA ATTTTTTTTT TTGAGATGGA GTCTCACTCT GTCTCCCAGC CTAGACTGTG GTGGTGCGAT CTCTGCTCAC TGCAACCTCT GTCTCCCGGG TTCAAGTGAT TCTCCTGCCT CAGCTTCCCA AGTAGCTGGG ATTACAGGTA CCTGCCACAC ATGGATGATA AATATGATCA TATTTTCTTG TTCTTTTCCT CCTCAGTTGT CTTCCCTGAA GAAAGGAATG CCTTTTATAG ATGACAAACT CCCATTCTCA AGAACAAGGA TTTTTGACCA ATTTAATTTA ATCAGATGTC TGGCTTTGAC CTAGAAACAC AGTCACGAAA CTTGGTGATT AGAGACCAAT TCCCAAACAT GAGCATTTCT TAGGAAACAC AGTAAAGATC TGAGAGACCC AAGAGCAGAA GGGCGAGAAA CCAAAAGCCA TCAGTTTGCA TAGGAAACAC CTTGTTTAGC CTAATCTTTT TATTTTTATT ACTCTATTAG TCACTACAAC TATTTTCTGA TTGCTATGGT GATAGATGGT TTAAAACAAG CCTTCATTAA GAATTGTCAC ACCATGGTCT CAGTCAAAAA CACCAACATT TTTATTGGTA TTGACAATTA TGGGAATATC CAATTCCAAG AAGACAAGGA GACCTCTGAA CTTTCTAAAT GAAGACTCCA ATCTTCCTGA TCTGATGGGA AGCAGCTTGG CAAGATTACC AACCACCACC ACAGAGAGTG GACTCTAAGC TAAGACTTAA AAGATAAGTA GAAATTATCC AGGTAAAGAT GTGTACAGAG AAGGAAGTAC ATCCAGGGGA AAAGAACAAT ACGTGCAAAA GTACGGAAAT GGTAAAAAGT AATACTACAT AGTCAAAGCC AAGCAGAGTT CAGAAGGGAT CTGGTGGTGA AAAATACGGC TAGAGAAAGC AGCAAGGATT GGCTTCTAAA ACCTATGTAG TATCTTGGAC CTTACCCTAA ATGTAATGAG AAGCTTCTAA AGAATCTTTC ATTTATTCAT TCATTGAACA AATATTTTGA GGCTTTCTGT GAAGAACATC ATTCTAAGTA GTAAAGATAC AGCAGTGAAT AGGACACATA AAATCCTAGA TCTCACAGAA TTGACATTCC AGAGAGGGAA AGGTAGACAA TAAATACATA AACAAATCAT TTAACAAGAT GATTTCAGAC AATGGTACGT ACTGTGAAAA AAATGAAACA AGGTAATGGA CAGCGAAAAG GCACTGGAAG GAAGCCTGCT TACCTTTGCA TGGTTAGAAA AGATCTCTCT AAGAAAGAGA CCACATGTGA GCTGCGACCT GAAGGATACC GAGAAGCTAG GTGTGCAAAG ATGTGGGGAC AGAACTTTTG GACTGAATAG CAAATACAAA TGCCCTTGGG TGCAAGCTTT GCCTGTTCAA GGACCAAAAA GAAGGCCAGT GTGCCTGCAG CATACTAAGC ACAGAGGAAA ACACTGTTAT ATGCTGAGAT TGGAATTATA AGTAGAGCCA GATAATATAG TCTCTTATAG GTCATAATAA GGCAACCAGA TTTTATTCCA AGAGGATTTA AAAATCACTG GAGGTTTTGC ACTAGGGTGA GAGGTGTGAT TTGTATTTTT AAAAGATAAT TCTGGAGAAT TAACTATAAT GAGGTAGGAG TAAACTAAGT TAGGGGCTAT TTCAGTGGCT CAGACAAGAG ATAATGGTAG CTTAGACTAG GATAGTAGTC GTAGAAATAA ATAAAAGTGG CACTCTACTT TGGGGGTAGA GTCTATAATA GGTTTGGTTT ATGGATCATA TATGAGAGTA AAAAAAAGAA AATAAATTAA TAATGGTTCC TAGGTTTGTA CCTGAGCAAC TGAATAAATG GGTGCTGTGA ATTGAGATAA AGGAGATTGA GAATCACAGG CTTTGTTTTG CAAATTAATT TTGAGAGGCT TATTAGACAT CCCAGTGGAG ATTTCAGGTG AGTGGAGCCC ATTGAAAGGT AAGGGACAGG GTCAGGTGTG GTAGGTCAGG CCTGTGATCC CAGGACTTTG GAAGGCCAAG GCAGACAGAT CAGTTGAGCT CAGGAGTTTG AGACCAGCCT GGGCAACATG GGAAAACCCT GTCTCTACAA AATATGCAAA ATATTACCTG GGCATGGTGG CATATGACTG TGGTCCAAGC CACTTGGGGG GCTGAGATGG GAGGATCACT TGAGTACAGG AGGCGGAGGT TGCAGTGAGC CAAGATCTCG CCACTGCAAA CCAGCTTAGG TGACAGAGTG AGAACCTGTC TCAATAAATA AATAAGAAAC GTAAGGGAAA AGGAAATTAA TCTGATCATT GGCAAATGCA TAGTATTTAA AGCCAGGGGA GTAGATGAGA TACTCAAAGT AGGTGAAGAT AAGGAGGCAA TGAAGGCCTA GGACTCTGGT GTACATTTAG ATGGTTATAA GAGGAATAGA AACTGGCAAA ATAAGTAACA CTGAGCACCC AATGAGGTGG AGAGGAAAGC CAGGAGATGA AGCATCATAG AAGGCAAGAG AAGAAGGGTG TCAAAGAGGC GAGGCAGTCA TCAACTTCTG GGCAGTCAAA TAATATAAGG ACAGAAAAGT GACCATTGGA TTTGGAAATA TGATGAGCAC TTTGAGTGGA GTGTTGAGAC AGAAGACCAA TTAGAGTAGA TTGAGGAGAT AACGAGAAAT GAGAAAATGT AACCTGCAAG CACAGACAAT TCTTGAGAGA CTTTTCTGTG AAAGGAAACA GACACAGAGT CTTAGCATGT CTTGTCTTTC TATGGGAAAT GTAAATAGTT TGAGATCAGG GATAGTATTT TATTCTGCTT TTTGTACCTC TACATTACCT AGCATAGAGC TAGCTAATGT GCACTTAAGT ATGTTCTCAA TTCTTATCGC CTGAATGACT GGATGGGTGA AAGAATGGAT GGATGGATGG ATGGATGGAT GGAAGGATGG ATGGATGGAT GGAAGACTTC TGATTTGCCA AGAAGAGGAT ACTGGTAGCA GAAATAAAAA CAGCACTGGA GAAAGAAGAG TTTAGATTTT TATTCTTTGG TGTCAGTTAG ACAGGAAAGT AAGACATTAG AAGAGTCCTT AGATAATTTA TGTAATTGTT CACTTAGGAT TTTTAAATGT GATCACTGAT ATTGGACATG TTCCTAGTGA AGCATTTTTG GTGTTTCACT GGTTGAAGTT AATAACTGTA AAATTATTTC CCGTTCAGGA CAGAAAAACA GAAAACTTGA AGCTCCTATT AGAAAGTTCA AGATTCTCTG GGGTTCTTAG GATTTACTGT TCCCAAAACT CTGTCAAGAA CAAGAAAATG ACCTGTATAC TTAACTGGTC TAGGCAACAG TGGAAAGACA ATTCTCAGAG AAGATTTGTT TTAAGAAGAC ACTTTCCATA GGAATCAAAC AATAGCTTTC AGTGACTAAC ATGGTAAGAC ACAGGGTGTT AGCTCTTTCC TTCCAACCTC ATGGCTGTTG TACCTTACCT TTCGACCCCG TGTTCCTGAA ATTGTTAAAT TCATAAACTT ACCAAGGACT AACCAGCCTC TGGGGAATTG CTGTATACTT AGCAAACTTA CAATGGACAT ATTTATAAGC CATAATGATA ACTGACTAAT AGGAAATACC CTCAACTGAA AATGAGAGAT CATCATTTGC AAATGAGTTC CCTTGCCCAG GCAACTACTG GGGAAAATGT CATGCAAGCA AAATTAATCT TTGAAATCCT CCTTTTCCAT TTTTTGTGTC TTCCTTTTCC ATAGGCACCA GAAATATCAT GGTGCCTGGA TCTCATCTCT ACAGAAAAAA AAAGTGATTT GATAAACTGA TTTATATTGT GTCCAAATGT GATTGTATTT TCAAAGATAA CCTAAGGGGA GAATGCTGTC TGGCCCAACA GCAGGCTCTC GACTTCATTT CAGACACTGT GGCCAATGGC TGGGAAACAG GTATGAACAG TAGGTTTCTG AGTCCCCTGG AATTATTCCA TTTATGTAGC CACCTCCATG ACAGGAAGCC TCCCTACTCT TACTTCCCAG TTTGTTCATT CATGGCACCA GGTTGCAGAT TAAAATTTGC TCAGTGACCT TTTATCTAAT AATGTGTTAC CTTCTTCTCT TAAAAAGTAC AAGGGACAAA TGCTCATGGT ATACTTTTAG GAGATTGTGG CTCTCTATTA ACAGTATTTA TTCAACAAAC ATTTATTGAG CATTTATATG TGCATCATGC TAGGGACTGG AACCTAGTAA GTGTAGCACA TATTATTTCA TTTAATCCTC ACAACAAACC CATGAGGTTG GTTTTATGAT CCCAATTTTT CAGAAGAAGA AACTGATATT CAGAACCAGT TAACTAACTG GTTCAAGGTC ATGCAATTTC TAAGATACAG AACCAAGAGT CAAAGACATG ATTTTAAACC AAAGCTTTTT CTGCTACTCC ACATTGCTTC CCTAGGTGAG ATCTGAGGCA TTCCGCGAAA AGAGAAGGGT CATAAAGCCA AGGGAAGACA AGCTTAGGAA AAAAAAGGGA AATGTCCTAA ATAAACAGCT TTCCTATTTA CCAGAAACCA CTAGTTTAAA AATATAATGG GAAAAATCCT ATTCACTTTA ACAATGTTAA AAAAAAAAAA GATAGAAGAA ACATAGGGAT AAACTTAACA CATTTGTAGG ATATGTAAAG AAACTAAAAG ATGTTAATAA TGGCCTAAAG AAAAAAAAAC TTACATGTAT GGGGAGATAG ACCATCTTAC TGGATTCTAA TATTTAATAG TCTAGGTGTT CCATTTCTCA CCAAATTAAT GTATACATTT AATACAATGT CAAACGAAAT ATCTTAGGAA TTGCTTACAA ATTGTCAGAT AATTACAAAG TTTACCTGGG AAATATAAGC ATATATGAAG AGTGAATGGG ACCCCACCAC TCCCCCCAAA ACAAAAAAGG TCTGAAAAGG ACAGAAATCA AGGAGAGTCT TGCCTGCCAG ATACAAAATT CTATTATAAA GGTGTATTGA TGAAAACAAT TTAATACTAG TGTAGCAATA GGCAGCAAAG CAATGAAACA GCATAAAAAG ACCAGAACTA TACCTAATTA TGATGAAGAT TTAAGGTATG ATAAACATGA CATAATTCAA ATCAGCAGAA bPI-109 142

ATTGGCATAG ATAGGGTTAA GACAAATAGC TAATCATTAG AGGGGAGGAA GGAAAGGAGG GAGGATAAAA TTAGGTTCCT GCCTTCATCT TACATTAAAA TAAATTCCAG ATGTATTACA TTTAAATTTT TTTAAAAAAA GAAACCACAA AATACTTGAA GAAAATATAA GTTGTTATAT AGTCTTTTGA TGGGAATTTT TTTTTTTTTC AGAGACAGGG TCTTGCTCTG TCACCTAGCC TAGAGTGCAA TGGCATGATC ATGGCTCACT GCAGCCTTGA ACTCCTGGGC TCAAGTGATC CTCCCAGCTC AGCCCCCCAG GTAGCAGGAA CTACAGGCAT GCGACACCCC ATCCAACTTA TTTTTTATTT TTTGTAGAGA CAGGGGTCTT GCTTTGTTTC CCAGGCTTAT CTCGAACTTC TGCCTTCAAG CACCTCAGCC TCCCAAAGAG CTGGGCTGAT GGGACATTTT TTAACATAGT GCCACATTAC CATAAATGAA AAGCTTGTAA AATACTAATT TTTAAAACTA ATATATATCA GAAATTTTTA TAAACAAAGT TAAAAAGCAA ACACAAAAAA TTTGTAGCAC TTATGACAAA TATATGTATA TATATGAATA CAAAAAGAGC CTTTACAAAA CAGTAAGAAA ACAATGAATA CTCCCAATGG AGTATTCAAA ACTAAACTGC TAAAAGCAAT TCAAAACAAA AAACATAAAC TATGCATATA TGTATGTGAA AAAGTTTAAC CTTATCAAAG AAGTAAACTC TCAAAGAAAT AAACATCAAA TAAGGAAATA GCCTTTTCCC ACAAATAACC AAAATCTGTA AGAATACTGA GCTGCGAATG TTTCAGAAAA AAAAAAAAAT CATACACCTA GTTCGGCATG TAATTAATAT AGATCAGAAC ACTTTAAAAA TATTTATAGG CCAGGCACGG TGGCTCATGC CTATAATCCC AGCACTTTGG GAGGCCAAGG CGGGTGGATC ACCTGAAGTC AGGAGTTTGA GACCATCCTG ACCAACATGG TGAAACCCTG TCTCTACTAA AAATACAAAA ACTAGCCAGG CATGTTGGCG TATGCTGGTA ATCCTGGCTA CTCGGGAGGC TGAGGCAGGA GAATTGCTTG AACCCAGGAG GTGGAGGTTG CAGTGAGCTG ACATTGTGCC ACTGTACTCC AGCCTGGGCA ACAAGAGCAA AACTCTGTCT CAAAAAATAA TAATAAATAA AAATAAAATA TTTATATACT CTGACCCATC AATTTGTCCA GCATAATTAG GCATGTGTAC AAGGGTTTAC ACACAAGAAT GCCTATTGCA ATATTGCTTT TAATGCTAAA AAAAATTGGG GAAAATGCTT TAAAAATATA GATTAAGACT GTACATTGTG GTACAGTCAT ATAATCAATA GTATACAGCT ATTATTTATT TTCAGCCACT GTCCAAAATA TAGCCTGGCC TAACAACATT CTGTTAGGAT ACGCAAGCAC CGTGAGGAGA TCAGCTATAA AGTATCAGTG TTTCACACCA CTGCTCCTTT GCTAATAACC TTCAATGGCT TTTAAAGAAG TAAAAAACAA AGGCAAAATT CCTTAGTCAG CCCTTAAGAC TCTCTGTTAC TTAGCTCAAA CTACCCTTTT CAACAACACT GCCCTAACCA GGATGAGTTT TTTGCCCCCC TGGAGTACAT TCAGCCTTTC CTTATCAAAC CTTCCTTTAA ATAAGTATCT TCTCCAGGAC CACTTCACTT TCTTCCCCAA TTTAGCATTT TCTATATCTC CAGGCCTACC TCTATAAAGC CTGTCCTAAC CACTCAAACC CTAGCTTTTT CTCTGAACTG CTAGAAATAT TTTTCTCTCA TTGGCCATTT AGGTAAAAAG GTrTTTACTG TTTATTACCT ACTCAATAAA AATTTTCTTT TTTTGAGACA AGGTCTTACT CTGTCGCCTA GAATGGGGGG AAGTGGTGTG ATCACAACTC ACTGCAGCTT CTACCTCCCA GCTCAACAGT CCTCCCACCT CAGCCTAGTG AGTAGCTGTG ACTACAGGCA TGTGCCACCA TACCCCACTA CTTTTCATTT TTTATTTTTT GTGAGATGGA ATCTCACTAT GTTACCCAGG CTGGTCTGCT GATCTCAATT GATCCTCCCA CTGTGGCCTC CCAAAATGCT GGGATTACAG GCATGAGCCA CAATATCTGG CCCCAGTAAG CTTTTAAGGC CATTAACATG AGGAACAGTG TTCTTTACAC TATTTTATCA GCTAGGGCTT TGCATGGAGT AGGAGTTTAG TAAATGCGGT TGATGGGTTA ATCAATGTGT GAAAATATTC AGAGCCACCA AAAACAGATA TTATGTCTAT TCTCATCAAC AATCAAAATT GAGTAAACAG CCATTTTCTA ATACAGGAAA CCACAAAACA TTGAATGGTG ACATTAAAAA ATTCCCCCAG CAGGAGCCAA CCAATTTTTT CATCCTGATC CAAGTTAGCA AACTGCAAAA GATAGGAAGC ACTAATGAGT GGAAATTTGA GTAGAAGCAT TTCTTATGAA GGCTGTCTTG ACTGGATCAC ATTTTTATTG CTGTTGGAGG TGCCAAATGT GTGTGTTTAT GCTAATCCTC CACCTCAGGC AACACACAGT CAAGGATCCT ACCAAGTGTT ACCGTCAAGT GTCTGTTGGC AGCTCAAGGC CCCAGCGTTG TTCCCTTCCA CTAGGGAAAA GACATATTCC AGGTACAAGT ACTCCCACTT TGATGCTACA GAGGAGTTGC TGAACTTTGT GTCATTAATC TCTCTTCGTT AGATCCCAAC CCTGTTTAAA TCCCACTATC TGCCTACTCT GGGTCTTCAC CAATTTACTA GATCATAGTT GGAGAAAATC TACAAAGCCT TGCTCCCTTT AGATTTAAAC AGGTCTCCGT TTAAATTTAG AATTGCTAAC TTCAAGCGGG CCCTTATGCG ACAGTATGCC TGTCAGTCAT ACTACATTTC CTCAATTCCA TTCATGTGAC TGCTCCATAC CCTTCCCTCT CTCTTCATAC TACTATTATC TCTTCCCCCC TCCCTCATTT TTAACTGATG ATCTTGTTTC CTATTTCTCT GAGAAAATAG AAGCCATCAA AAGAGAGTTT CCACAAACTC CTACTGCCTT ATCTAGCCCT GTACCATATA CTTTGCATTT CCTCTCATTA CCATGGATGT ACTGCCTATC TGTGCTTCTA TCTAAGGCTA ACCCTTCCAC TTCAGTTTTG AATATTATCA GCTCTTACCA ACTCAAGGCC ATTGCTCTAG CAATTCTCTC ATTCTCTCTC ATTTTCTTCC ATCAAGTTTT CCTTTTCTTC AATTAACAGA GTAGCTCCTA AAGGGAAAAA AAAGTCTTCT TTTTCAATGC TCATCATCAC TGGCCATCAG AGAAATGCAA ATCAAAACCA CAATGAGATA TCATCTCACA CCAGTTAGAA TGGCAATCAT TAAAAAGTCA GGAAACAACA GGTGCTGGAG AGGATGTGGA GAAATAGGAA CACTTTTACA CTGTTGGTGG GACTGTAAAC TAGTTCAACC ATTGTGGAAG ACAGTGTGGC GATTCCTCAG GGATCTAGAA TTAGAAATAC CATTTGACCC AGCCATCCCA TTACTGGGTA TATACCCAAA GGATTATAAA CAATGCTGCT ATAAAGACAC ATGCACACGT ATGTTTATTG TGGCACTACT CACAATAGCA AAGACTTGGA ACCAACCCAA ACGTCCAACA ATGATAGACT GGATTAAGAA AATGTGGCAC ATATACACCA TGGAATACTA TGCAGCCATA AAAAATGATG AGTTCATGTC CTTTGTAGGG ACATGGAGGA AGCTGGAAAC CATCACTCTC AGCAAACTAT CACAAGGACA AAAAACCAAA CACTGCATGT TCTCACTCAT AGGTGGGAAT TGAACAATGA GAACACTTGG ACACAGGAAG GGGAACATCA CCCACTGGGG CCTGTTGTGG GATGAGGGGA GTGGGGAGGG ATAGCATTAG GAGATATACC TAATGTTAAA TGATGAGTTA ATGGGTGCAG CACACCAACA TAGCACATGT ATACATATGT AACAAACCTG CACGTTGTGC ACATGTACCC TAAAACTTAA AGTATAATAA AAAAATATAT ATATATATAT AAAACAACTA AAAATAAATC TTCTTTTTCT GCAGGATCAG TCCATCACCA CACACACAGG CTGTGTTTTA TGTTGTTCCC CAGCTTAAGA GATCGTTCTC CAGATCCCAC TGCTCCTTCC AGTTGTCACC TCAGTTCTCC ACTTCTTTTT GCTGATAAAC TACTCTAACT AGTTACATAT GATTTCTGTC CCCAGGTCCC CTCCCTCAGT TGTTTTGAAC ATAATCATTT ATATCATTTA TCATTTTCAC TCTAATTGCA CAACCAAAAA CTCCCTTTTT TTTTAGATGG AGTCTCACTC TGTCACCTAG GCTGGAGTGC AGTGGCATGA TCTCGGCTCA CTCCAACCTC CGCCTCACGG GTTCAAGTGA TCCCCCTGCC TTAGCCTCCT GAATAGCTGG GATTATACAC ATGCACCACC ACACCTGGCT AATTGCTTTG TTTTTGTTTG TGTGTGTGTG TGTTTTTTTT TTTTTTTGGA CAGAGTCTCA CTCTGTTGCC CAGGCTAGAC TGCAGTGGCA TGATCTCAGC TCACTGCAAC CTCCACCTCC TGGGTTCAAG CGATTCTCCT GCCTCAGCCT CCCGAGTAGC TGGGACTACA GGCATGCACC ACCATGCCAG GCTAATTTTT TTGTATTTTC AGTAGAGACC AGGTTTCACC ATGTTGGTCA GGCTGGTCTT GAACTCCTGA CCTCAAATGA TCTGCGCACC TGGACCTCCC AAAGTGCTGG GATTACAGAC TTCAGCTACT GCGCCGGGCT ATTTTGTGTT TTTAGTAAAG ACGGGGTTTC ACCATGTTGT CCAGGCTGGT CTCAAACTCC TGACCTCAAG TGATCCGCTC GCCTCAGGCC CTCAAAGTGC TGGGATTACA GGAGTGAGCC ACCATGCCTG GCCATAAAAC TGCCCTTTGT TAATATGACT GTTGGCCTGC ACATTGTCAA ATCCAGTGGC ATTCATCTTA CTCGGCCAAC CTACGGCATT TGACACTGTC TGTCTTTCCT TCTGTTCCTC TATCTGTTTC CAGTATACTG GCCTGGCTTT

CTTΠTACCT CTTTTATATG CTCTTCCAGT CTCAGGCTCC TTTGGGGATT TGAAGGTATG TTGCATTTTG CTATTCAATG

AATAATGACA AGTAATGATC ACTTAAGACA TTAAGTGGTC AGTTCCTTTA CTAGGATAAA AATAATTTTC TTCCCAACAT GGGGCATATT CCATTTCCAG TCTGACTGTT CTGTGTAATC TTTGTATTCC TTGGCAGCCC CTTTTATATC AGTTCATCTA CTGTGCAGGA AATTGGACAA ACATTTGCAC TGGTATAACC AAATACAGTT GAACTTTTGG CTTGACTCTT AGCTGAACTC bPl-109 143

ACCAAAAATA ATTTCTGTAA GAGACTGAGA CGTCTACGAG TAGGTTTTTC AGAATTAGTA AACATAAATC AAGGATACAC AGGTAGATTT GAATTTCAGA TAAACAACAA ATACTTTTTT AGTATGTCTA CTGAAATATT TGTATCTTAT CTGGCAATTC TACCTGGTAC AGAACTAATC CATTCTCTTG AAAGATCTTG ACTCTGTAAT AAGTTCTTTG GTGATGGAAG GGAGGTATTT CTGTAATTAG AGTCACTGTC TTCCTCCCAG TTTTTTATCC TGGCCCAGAT CTGCAATGAA CACACGACAG AATCCAGGGG GGATGAAGAT GGGTGCTTTG CAGGAAAAAA AAATTAAAAA CATCTGAAAA AGCTTTTGTA CTAAAAGAAT GTGATCTAAA AAAGAAAGCA GGAGAACTTT CTGTCTGCAC TTTACATCAG AACAACCTTG GCGTCTAGAA GCTGTGCCCT GTGGGAAGTG GTGGTGCTTG GTAAGAGATG CCAGGACCAG TGGTACCCAC TGGGAGCACT GCCAATACCC AGCAAGGAGC ATGGGTGCAC AGTAAGGCAT TGCACTGTGA TTCAGCATAA AATAACAATA AGGGAACGTC ACGGAGAAAA GGCCAGACTT CCTTTGTTTA GAATGTGGGA AATGTCTTCT GAAAAATGGT AGTAAAAAAG CATGCTTGGA TGGTCCACTC CAGGCAAAAC TGACTAATCG GGGGTCAGGG ATACAACCCC TGCATCATAT GTTTGTTTCT GTTGGGCTGA CATGAGGTTC ACTGTGACCA CTGTGGTTTA ACCCCATAGT CTCCTGGAAA TACAGCCAGG TCAAGAGAGC TCCACATAAA ACATAATCAA AAAAATAAAC TCAAGTTTCC ACTGATCAGC TTTTCACAAC TCTTATCCTT TCACTAACTT TGGAGCAAGA TTTGAGAATT GGATGGCTAT TTGAGGGCTA TTTCTGCGCT TTAGTTCAAT GTTTTGTTCT TTCTTTATTA GAGAACTATG GTTTTTTATT ATATTTACAC TTTAAGTTCT AGGGTACATG TGCACAACGT GCAGATTTGT TACACAGGTA TAAATGTGCC ATGTTGGTTT GCTGCACCCA TCAACTCGTC ATTTACATTA GGTATTTCTC CTAATGCTAT CCCTCCCCCA GTCCCCCACC CCCCGACAGG CCCTGGTGTG TGATGTTCCC CTTCCTGTGT CCAAGTGTTC TGTTTATGTG ATAGATTACG TTTATTGATT TGTGTATGTT GAACCAGCCT TGCATCACAG TCACTTGCTT ACAAGAAACA AACACTTCAC AGATGGATCA TTATGTGTGA TAAGTGAAAT CCAAGGATTT ATGCTCAGAG GTGGGCTTAA CAGGTAGGAA GAGCAGTATT TTCCTTCAAC CATGAGTGTA TGCAGGTTTT TCTTTTCTTT TTTGAGATGG AGTCTCACTC TTTTACCCAG GCTGGCGCGC AGTGGTGCGA TCTTGGCTCA CTGTAACCTC TGCCACCTGG GTTCAAGCAA TTCTCCTGCC TCAGCCTCCC AAGTGGCTGG GATTACAGGC ACCTGCCACT GTCTCCGGCT AATTTTTGTC TTTTTAGTAG AGATGGGGTT TCACCATCTT GGCCAGCCTT GTCTTGAACT CCTGACCTCA TGAATCATCC TTCTCAGCCT CCCAAAGTGC TGGGATTACA GGCATGAGCC ACTGCGCCCA GCCCACAGGT TTTTCAAAGA CTAAACTTAA AAAAAAAAAA AAAATTTCCC AATGAAATAT AAAACTAAAG TGCTAAACTG TGATAGACTG TTTTACAAGA ATGCCAGTTT TCACAAGTGT CTATAGAACA TGTAATTTAG ATAGGTAAGA TGAAATTTTG ATAATATTTG ATGGCAAATT TAAACAGGTA TACAACAAAA ATAAAATTCT AAGCCCCTCA ACCAACTGAA TGGACTCCTT CTCTCAGCCA AAGGAATACC AAAGTAAACC TGAAAAACTA GTTTTGGCCA GGATTGGGGG TAGGTGGGGG AAGCCCAACA TGACTCATTA TTCTCTCCTC CCTTTGGAAT TCAGGCACAA CTGAATGTCA GCATTGACAC TAAAACACAG ATCTTAAGAC TGACAAGCCA GACTCTTTGT AGCAGAGAGC CAGGCCCTGG AAGAAATCAA GTTATTTTAT CCCAAAAAAT ATTTCTTTGA TATATTTTCA AATGGCCCTG CAAAGCTGTC TCTTGTGGGG AAAATTGACA TGCTGTACAG AATTTCCTTC TCTTTCCAAG TTTTTACTGA TCCAGGAGAG ATTTAACTAA GAGGCTAGCA TGTTTTTTTT TTTTTTTTTT TGAGGCGGAG TCTTGCTCTG TTGCCCAGGC TGGAGTGCAG TGGCGTGATC TCAGCTCACT GCAACCTTCG CCTCCCGGGT TCAAGCGATT CTCCTGCCTC AGCTTCCCGA GTAGCTGGGA TTACAGATCC ATGCCACTAT GCCCAGCTAA TTTTTGTATT TTTTGTAGAG ACAGGGTTTC ACCATGTTGG CCAGGCTAGT ATTGAACTCC TGACCTCGTG ATCCGCCCAC CTCGGCCTCC CAAAGTGCTG GCATTACAGG CGTGAGCCAC CGTGCCCAGC ACAAGACATT TACCGTCTAT TCTCTCTGAA GCTACTATCT AGAGGCTTCA TCAACATAAT AAGACCCTTG GTCTCCACAA CTCCTTATCT TATCCTATTA GTTTCTACTG ATTCCAGGTC TTTAGATAAT AACAACTCTT TCAACCAATT GCCAATCAGA AAGTCTTTGA ATCCACCTAT GACTTAAAAG CCCCACTCCT TCAAGTTATC CCGCCTTTCT GGACTGAACC AATGTACACC TTATATGTGT TGATGGATAT CTGCCTGTAA CTTCCATTCC CCTAAAATGT ATAACATCAA GCTGTAACCC AACCACCTTG GGCACATGTT TTCAGGAACT CATGAGACTG TGTTGCAGAC CTTGGTCACT CATATTTGGC TCACAGTAAA CTTCTTTAAA TATTGTATAG AGTTTGGCTT TTTTCATTGA CACAGGAAAA ATAAAGAATT GGAAGGTCTT TCATCAGTCA CTGAGCCAGC TTCATATCTG ACTGAGGTCA TACAGTTCAG TGATTTGTAG CTTTGCTACT TAGATTGCTA TCCATTATCT AGAAGCATCA GGATCACGTG GGACCTATTG GAAATGCAGA CTTTCCTCCT AGAACCCAGG ACCTTGGAAT ATTCTTGGCA CATAGTAGGT GCTCAATACA TATTGAACTC CTAGGTGCAA TTCATTAATT CATGAATTAA TGAATTAACA CGCTCTCAAA GTTTAGTGCT TTTTCACAGA CTAGTCTTTC TGCCTCTTAA GCACTCAGCT CACCACGCTT CCAGTCTCAC TCCCCTATTA GTCTGATTAA AATCTGCTTA CATGTGAGTC TGAGATCAAG TGTTATCTCT TCTGAGAAGT CTTCCCTCAC TGGCCCAAAG GAATTTCTCC TCTATTTTAG CACTGTCCCA GTTGACTTGT CATTATTCTA GTCTTTTTCA TATTAGTTGT TTTTCATATA TATGTTATTA AGGAAACTAG TCATTTCCCC TAATAGAACA AAATTGCTGG CCTTTGGGGT TGGCAATGGA GGGGAGGCTC TTCTTGAAAA GGGGGAAGAG TGTTCTCCTA ATATTTTTCT TACGAGATTT ATGTTGCTCA TCTTTAGCCT TTAGTCCCCC ATTGCCTGCC TACAGTTGGC AGAGACCATC TGTTCTCTCA CTGTCAGGAA CTGTCTCAAT TCTTGAAGTT CAGAGTCAAA AAAGAAGCAA GTTTTCCTAG CTCTTTGATC AACTTTCAAA GTTTTACTTC CATTTGAAAA TTTACTAAGT CACCAGGAGA TGGTTTATAC TGAGAAATAT CCACTCATAC TCTTCCTCTT CAACTTTCTT CCATATACAC CCTATTACAG GGATATAGTC TTACTCTATA GCTCAAAAGG ATGACCCTAT CAGAAACCTG CACAGTATGT AAAACATTCT CACCAGAGGT TCACTTGTGT ATTTCCACCC TAGAATGGAA GCTCTACAAA AGCACAGAAT GTATCATTTT AACTTTAGAT TCTATTTTCA CACCCAGTGC TTGACACATG ATTTGAAGTT AATATTTATT TATCAAGTGA TTGTTTTAAA ATCATGACTC ACTCAACAAA GTTATAAGAA TAAGAATAGT GTTACAGAAT TGGTATACAC AAGCTGACCA TAATCAACAC ACCTATTATC ATTTTTTTGC GACAGGTTCT CGCTGTCTCA CCCTGGCTGG AGTGGAGTGG CATGACCACG GTTCACTGCA GGTTTGAACT TCCAGGCTCA AGCAATCCTC CCACCTCAGC CTCCCACATA GCTGAGCCCA CAGGTGTGTG CCACCATGTC CAGCTAACTT TTTAATTCTT TGTAGAGACA GGGTCACCCT ATGTTGCCCA AGCTGGTCTT GAACTCCTTG GCTAGAGAGA TCCTCCCTCC AAGGTCCCCC AAAATGCTGG GATCTCAGGC AAGAGCCACC ATGCCTGGCC ATAATCAATA CACTTTTAAG AATGCTAGAA TGTTATATCA GATGCATACT TCAGCACTAT CTCAAGCAAA CTGGGGTGTG GGTTATTCTA CATATAAAGT TCAGCAGTGT TGTTCCACAG TCCCAAACTC CAACTGAGGT CAAATGTAGG GTGCAGCAAG GTCACTGGGG CTGTCATCAA GGGCCTCTCC TTGCACTCTT GCCAACCCTG TTTCTTGATT GTCTCTACCA CCATGAGTCA CCAGCAATCT CCCACAGTCA CTTCTTTAAA AGTTCACAAG TATTGTGTGA ATTGCAGGCA ACCCCTTGAC TCCCTGATTG CCTGGTCTTC TTCCTTGGGC TCTACCATTT TTTTTCCCCA GCACTCTTTC TGCTGCTCTA AATTTTAATT CATGCAATTC CATATGTGTT TCTCTATCAT TCTTCATCTC TTTCCTCTCC CTTCCATCCA ATTTTGTTTG TCTGTTTGCT TGCTTGCTTG CTTTAATACA TTTCTCTTTT TCTGAGAAGG CTTGAGTCCA AAACTCTCAG TTACCTGTTG TTCTGTTTCC CGTTAGTTAA TCTCCGAACC TTCATAAATT AAATCTGACA AAGTCCCCTG ACTAACAAAG GAAATGCACA AGTCACAGTA AAAGGGGCAC ACACAGAACA CAAATAGACC CAGGGTCTTT TCTGTTCATC ACTCAGCTTT TTATAGGAGA TCCAGGAGAA ATGAAGTGGA AAGGGAAGTG TGTTGAGTTA CTATACAACA CAAGAGTAAA CTTTCTTATA AGTGGTAATT TTTTTTTACA GGAATAATTG AAAATGGAAA TTACCTTCTC TACTCATAGT AAGTACTCAG TGCGTTCTTG ATGGGATGAG AATGTGTTTG AGCTTTAGTG TAAGGCAGAA TTCTGTTTAG TCTGCCAGTA TTGGAGAAAA ATAAAACACA AAGGGACTGA CATGTAGGAA GTGGCACCTG GGAGGGTCTC

AATTCTTCCT ATTACAAAAA TGCCCCAGAG AAATAAAAAG CTTGTGTACA TGTTGAGATG GGAGAGTTCT CTGGCCCCCC TCGCAGGATG TGTGACAGTG GGGTGGCTCT CTGCTGCGCC ACCATGAGCT CAAACCCCTC ATAGGAGGGG GAGCACACAG GCAGGAAGGT GCAGGAGCTG GGCGAGCTCT TTGGGCTCTG GCCCCGTGGT ACTGTCTAGA GGTGGGTGCC TGCAACTCCT GAAAGCCCAA GTGGGCATGT GTTACAGTGC ACTCTTTCAG CTTTGCTGTC TGCAGCTTAA GCGTTAACCA GCTCAGTTTC TTCTTGGTAC CCAGGTCCTT GTCTGGCATC CAGGAAGAAT CAGGTTACAC ATGGACTTGA AGGATGAATG TGGGAGTTTT ATGGAGTGGT GGAGGTGGCT CTCAGTGGGA TGGATGGGGA GCTGGAAGGG GGATGGAGTG GGAAGATGAT ATTCTCCTGG AGTTTGGCTG TCCAGCAGCC GATCTCCTCT CCAGTCGTCC CCAGCCTCTC GACGTTCAGA TGCTCCTCTT CTCTCCTTCT CTGCCATGCT GTTCTGCCGT TCATCTGCCT GTCTCTCTCT GGAGCCTGGA ATTTGGGGTT TATATGGTAC ACAATAAGGG GCATGGCAGG CCAAAAGGGA ACTTTTTAGG TGCAAAAAAC AGGAATGCCT CTTCTCACTT AGGGCTATAG ATTTTCAGGC TTGAAGGTGG GGCCTTTACC AGCGAACCTG TATTTCCCTG TCTCCTCTGC ATATCAATGT AATCAAATAC TGGGCTGATC CAGGATGTTT CTTTAGACCA ATTATGGGTA AAATAATTTA CATTCAGGTT TTTATATTTG CTTTTGTCAT TTCTTTTTAA GCAATCATGT AAAATATCTA TACGACAGTA ATAGATGATA GCGAACCTAA TTAAAATTAC CAGAAACTTA AGAATCTCTA ATGATTTCAA CTGTAACTAA GGTTATTTCT CTTTATGTTG AACAATGTTG GGAGATAAGA CACAAGAGTT TCTGAAGTAT TTCAGAAACA CAAAGAGGGA GGTTATATAA ATAATATTTT TTTCCTACTT TGGGAAAATG AAAGCTAGTC ACAAAGTTAA ACGAGTGGTT ATTTTAATAT TTAAAATACA GGCTTGGATG TATTTCCTGT TAAAGAAAAT AAAATGCAGA ATATTCAAAA CGTCTGACCA CCCTTCTAAG AAAATGCATC TCTGAGGTAT TTTTCCTTAG AAGTTATTGT AAAAATCCTG GAGAAGCTTG AACACAGCAA AGCAAACAGG ATGCAGAGTT TAATCTGTGG AAAGCTTAGG GAAGAAAAGC AAATCATTAA AAATAGGTCT TCCTCTGAAG ATTTTTAAAA CGCAAAGAGG GTGGAATAGC AATGATAATA AAAAAGCTGG CATAGAGAGT GGCACAATTT GCTGTGCCAC TGAGCTGACT GGATGTGTTC TGAATTTCTA GGCATTAGTG TACCTTTCCA CACGCATTCT CCCTTTAAAA AAAATGCCCA CACACTGAAT ACTTTTTTCA TGCAATTTAA AATAAGCGCA CCATCTAGTT TACAGAAATT CACTAGAAGT TATTTATCCT AAAATAGCAG AGATCTAGAA GAATTTTGAG CTCTAGGACA TTTTAGACAC ACAGAAAGAA GAATCTGGAC AAGTCTTGAC CAGACATGAC AGAATAGAAA TTTCTTTTCC TATTTATCTC TTTGAATAAA ATTTTCAGGA TCTTACAGTG GACAAGTTTG TTATCTACAC ATTGTGAAGC ACATTGATTT CTCCTCTGTA GCCTTAGGAA GATCTGAGAG GTGACTGAGC TGATTGAATG ATCCGTGACC GCTCTACTGG GACCAGTAGT AGAACTTTAC TGGTGGAGAC CTGCTGGAGG TTTGAGAGCA GACTTTGAAA ATTACTAGAG CTACACAGAT ACTGTGTGGC TAACTGGATT ATGTTTAGAG GCTTTCAGAA CTATGCTGCT GCTGCTGCAG TGTAGCCAGG ACGCACAGAG AACATCTAAG GCTCTTGAAT GGGGCGATAG GGACAGATTT CAGCAGCCAT CTGACTTCAG TGCTCATTTT GATGCTTTCC CTGCAGGGTG CAGTGTGCAG TGTGCAGTGT GCAGTGGTGG GAGGCTCACA CAGGAATACT TGCTTCTGTA GCCCTAATTT CCGGTTCAAA CTCTGCATTC ACCTTGACAG ATTCTTTCCT TGGCCAAAAT TTAGTTAGGC TTCTGGGCTT TCTCTTATGC CCACCTGCAG ACTTTTTGGT AAAATCCAGT TTTAGTAAAG AGCTCTGCTA AGTCAGTTTA GCAAGAATCC CCACCTCAAA AGTCACTATC TCCCTCCCTG GTAGTGTCTG GCTTGTCTTC AGCGAGAATT CTATTAGGTT CTGTTAGATT AGAATCCTCC TTACCCTTGA TGCTTCCTCT TAGTATTTTT TCATCCACTG ACTCCTTGAC CCACCTTGCT CCTCGGCTAT AAATTCCCAC TTGCCCATAC TCTGCAGTTA AGACTATTTT CTCCCCACTA CTGCAAAATC CCATTGCCAT GGTCCCTATA CTATCTCAAT GGTAATGAAT AAAGTCTGCC TTACCATGCT TTAACAAGTA ACATTGAACC ATTTTTTTCT TTAACAATCT GCTGCACAAT GAGATTACTA AAACTTTATT CCATTTTGCC ATGCTGGATG TCCTCAATGG AATGGCTCTT GTGAGCACCA AATCATTGTG AGAAGGAAAA CCCATCTCTT ACAGCCCCCT GTAACGTGAT GTATGTTACA TGTGATGTAT GTTACATAGT TTTTTTTCAT GTTGATCACT TTTTGCCCAT TTTCCTATAT CTTATCAGTT GGAAGACTGT GGAAGTTTGT AGTACTAAGC CACAAGATGA CTAAGAAGAG TTGAAAGGGC AAGTGGGGCT AAAAACAGAT TTTGTTTGAC TTACCCCACC ATTCCCCCTA TCATGGGGCT GAATCTGCCT GGAGGAAGGA GCATCTTTAT CTTTGTACTG TGAACCACAC AGTCTAGCAG CAGCACAGCC AAGGCACTTG GGGTTTCATG AGACTAAGTA CATGCAATTC TATTGTAAAG GCTTAAAATA TATACAACTG ACCCTTGAAC AACATGAATT TGAATTGCAT GGTCAGTTAT ACGCAGATTT TCTTCCACCT CTGCCACCCC TGAGACAGTA AGATCAATCA ATCCTCTTCC TCCTACTCCT CAGTCTACTC AAAGATACTT GAAGTCTACT TGAAGATGAC AAGCACAAAG ACATTTATGA TGATCCACTT CCACTTAGTG AATAGTAAAT ATGTTTTCTC TTCCTCCTAA TTTTTTAACA CTTTCTTCTC TCTAGCTTAA TTTATTGTTA AGAATACAAT CTATAATACA TATGACATAC AAAATATGTC TTAGTTGACT GTTTATGTTA TCTGTAAGGC TTCAGGTCAA GAGTATGCTA TTAGTGGTTA AGTTTTCGAG GAGTCAAAAG GTGTATGTGG ACTTTCAACT GCAGGGGGGT GGGCACCCCT GCCCCCATGT TGTTCAAGGG TCAACTTTAC TGCCAAAGGC AAGCCTTTAC ATCCACTTTT TCCATCCCAT CAGTAAATGG AAAAAGATAG CTACAGTATC CCTGCGTCAA ATCTTTTTTT TTGCAGATCA CAAATTGGCC ACTCACCTTG CTCTGTGAGG GGTAAAATGC CCCACTTTCT TTAGTAATAT TTAAGTTAGA TAATATTTAA GTTATAAAGT TGTTCTTTGT AATCGTTAAT TGTAATTTTT ACATAGTTTC TTTCAAACAG AAATAGCATT TTTGTTAGAT AACCTCCCGT ATAGATGATG AAACTCCTTT TAAGGGCTAT CTGAATTTTA ATTCCTTGAA AAGGCAGAAA TTGGATAGCT AGTAGTCATA AATGTACTGT GGCTTCCCCC AACCATCTGG GCTATATAGA AGCTGCATCC TTGGACTGCA GTAGAGGAGT CTTACAAAGC ACAGAGCAAC TTCTCTCCTG GGTTGCGCTA GTTATGATGG CAATTTTAAA TGTGTACTTT TACCCAAAGA AAATCCTTAT TATCAACAAT CACAATGCCA TCATAACCAT GGTATAAAAA ATTCAAAATG TCCCAGCTGA AGTGGAGGCA AAGACTCAAG TTCATGGAGT CAGAGTTTCC TTGCTATTCC TCTTTTTCAA ATGACCATTT AGTAAGCACC TGAAGAAAAT ACTATGGACG GCATTGAAAA GTGAAGATAG GTTTAATCTT CTCGAAAATC TAATTCTCCA GATGAAACGC TGACACTTAT CCACCCCACA GACCCTATAG CAGATGTGTC ACTGGCCATC ACATTTGACA CAGAGAAGTC ATAACTCAGT CAGCACAGAG ACATTTCCAT GAGTTTCTGA ACCATGGACA GAACGTCGTC TGTGGGACAT GAAAACTGGA ACTTAGAGGA CAGGCACATC TGAGAAATGG GCAGTTTAAA GGCAGAACAT AGCACATATG TGACTGGGTT TTAGAAGCAA ATTTACAAGA CGCACTCTTC TTCATCCTAA ATAATCTGCA ACCAAAGCTT CCAAAAAAGA CAATTTAGGA ATGCAGAGGT GAGGAGTAGG GAGGGGAATG GGATGAGAGA GAGTGGAGAT TAATGGTGGG CAGAGCGAGG TTTAGAACTT AGTGGTTTCT TCAGGTTCTG AACTGAAATT TGTATACTGT AAAGGCACAA ACACCATTTT TAACAAAAGT GAGCAGGACT TCCTATCTGG TTCAGAAAAT AGGTGAATAA ATAGTACGAA TTATTAAAAA TAATAATTTC CACTTATACA TAGGAAACTT GATAGGAACC ATGATAAATG CTTAACTCTT AATCTTCAAG GAACTCTGCT AGGGATATAA TATTATAAAT CTTGTTTTGC AGATGGAGAA ATTGAATTTT AACCCAAGTT ATCATAACCC TTAAATGATT AAATGATACT GTTACATGAG AAAGCTGCGT ATCTGTTTCC TGGATTTGTA GCCATAATTT GTGTCTCAAG TCCCTTTTGC TGCCAGCTAT CTTGGGTAGG TGTGTTCCCT TTGGGCTGTT TGATACCCCC ACATTTATCT TTTTTTTTTC TCTTTTTTTG TTGAGAGAGT CTTTCCCTGT TGCCTAGGCT GGAGGGCAAT GGCGCGATCT CGGCTCACTG CAACCTCCGC CTCCTGGGTT CAAGTGCTTC TCACGATTCT CTTGTCCCAG CCTCTCTAAT AGCTCGGATT ACTGGCATGC ACCACCACGC CCACCTAATT TTGTATTTTT AGTAGACAAG GGGTTTCTCC ATGTTGGTCA GGGTGGTCTC AAACTCCTGA CCTCAGGTGA TCTGCCTGCC TTGGCCTCCC AAAGTGCTGG GATTACAGGT GTGAGCCACC ATGCCTGGCC CCAAATTTAT CTTTAATGCC CCAAATTATC TAGTTCCCAT GACTGGGCTT CTGCTTTGAT CCTTTCTGCA CTTGCTGGAC CCTCTCCCTG

GGAAATGAGA TTGTGTCCTG AGCCCCTAGT TAGAGGCTAT GTCTCTGCTG TTCCTGAATG GGCCTCCTGG ATGAGACCTC ATTAAAAGTC TAATTCTCTT GGAGAATTGA GAGATACCTA TTTGTCTCAA AATCATTGAA ACCAATTAAT GTATTATGAG CCTCTATCCA GTGATTTGTA CCTCAATTCC CCAATCCAGC TGTCAAGGCC AATTTCTTCT ACCTTACCTA GTAGGTAAGT CTGGAATTGT AGCTGTGGCA TTTTCAGTAA TGGTACTCTA GGTTAGCAGT CCCCAACCTT TTTGGCACCA GGGACCAGTT TTGTGGAAGA CAATTTTTCC ATGAAGGGCT GGGCAGGGGA GTGGTTTCAG GATGAAACTG TTCCACCTCA GATCATCAGG CATTAGATTC TCACAAGGAG TGCGCAAGCT AGATCCCTCA CACATGCAGT TCACAATAGG GTGTGCACTC CCATGAGAAT CTAACACCGC TGCTGATCTG ACAGGAGACA GAGCTCAGGC AGTAATACTC ATTTGCCTAC CGCTCACCTC CTGCCGTGCA GCTCAGTTCC TAACAGGCCA CGGACCAGTA CTGGTCCACG GCGCAGGCAT CAGGGACCCC TGTTGCTAGG TATAAGCATC TGGCTGCTGC ATGTCTTCTG TGTAGCTACA TCTGTATGTG TATCTGATGA GATATAAATT ATTTGATTAT AAATTACTTT CTTCATATTA GAGTTGTGAA TGAGTATCAC ATATAATTAT ACATAAACTA GGAATATGCT TTTTAATAAT GTATATAAGT AAGTTTCCTT AACTATGACT TTCATCTTAG CGTAGTAAGA GGGTGCTAAG AAATATTTGT GATGAAAATA GGCATTGGTA GAGTTGAGAC CACTGGGTGA TGAAAGAGTG TAAAGATTTT AAAGCCTTCA GATGCTGGTT CAAGGTGAGA AATGTGATTG GGAGCAAATC AATTAACTTC TTGAAGTCTT ATAGGGCAGT TATGAATACT TAATGTTAAC ATATGTAAAG CTCTTCTGCC CTGTATACAG TAAATGCTAG TTAGCTATTA TGATCACTAC TAAAATGGGG ATGACATAAA CCTCATAAGG TTTTAAGTAT TATGCAAGAT ACTATACAAA GTCCAGTAAA TATCACATTC AATTGAATCC ATGATGTCCG ATTATTTTAG CTACTTCCAA GAGAGAAAAA AATGCTGTCA GTTTTACTGT TCTTATAGAG AGCAAGGCAG ATCCCAATTC CCAATGTGGT AACGTGAAAA TTTTTGCATT TGAATCAACA AAACACTTTC TCCTTTCTTT CCTACTATTT AACAACTGGT AAGTCTATAC TCCCCCAAAT CTGGAATTCT CCTTTCTTAT TCTTTTTCCT CCTACCAAGA CCGCAGGATC TTTTACTTGG CTATAAGGGG TAAACCTCAA GTAGTACAAG TTCTCTGTAT TACTTTTATA CTCTGTCACA GATTCCCTTT GTTTCCTCAT CTCCATGTGA ATTTAGTTAA ATTCTCAGCA TTCTGATCCT TACTATACAA GGTAAATGAA TATAAAAACA AAACGAAACA AAAACCTCTT CCTATTTACA TAAGGCCCCA ACCTAATATT TAGTGATATA TATTAATGTG AACAAGGAAC TAACGAAGAC TGGGAAGAAA TTCACAGACT TGAGAGAAGA AATGGCAGGA TTTCCTGGGA ACAATTTCAT GTAACGTCAA AGGTGGTAAA AGGTCAAATA GAATGAAGAT GGAGAATACC GGATTTTCTT ACAAAATGAT TTCCCAGGAG ATCTCATCAA ATGCACGAGG ATACCTTCTC AGTTTCACCT AGTGAGTAAA AGACTGGTAA CATAGCTCAC TTACAATTTG GATAAACAAA ACTAAACAAA CAACATCAAA ATTTCAGAAA AAATAATAGC AAAACAGAAA TCAAACACTC AAATTTTTGG TCCTTCTGTT TATTTCATTT TGGATACTCA GTGAATGTTA ATTAACCAGG AAACTTAAAA GTTATTTCAA TTATGAACCT CTTCAATCCT TCATCAATTA TTTTGAGTAT TCTGGTCTTA AAAACATCTC TTTCTTCTAC AAACTTCTGA AAGAGATGAA CACCTCCACC TACACCAAAA TAATGTGCTT TGCTGGCCAA AAGTACACGT CCATTTTTAC TTAACAGTCT AAGGAAAGTC TGGTGCAAAT TACTATAATA ATCTGGGTTG TAAATGGTTT CTGAGGTGAG AATGAGATCA TATTTTACAA AAAGTTTTTC ACTACTTAGT ACAAGCTTAC AAAACTCAGA CCACTCACCA GAAAAAAATC GGCATTTATA TAGTTGTGTT ACTTTTGGTT TCCTGCATCT TTTCACATCT GGCTCATTTA CATCATTTTC TTCATCTTCC AAAGTGGAGT TAGCTACTAC ATTAGGTAAG GTTACTTCAT CAATCACCAT ACTGTTATAA TCTTGAAAGT GAATTTCTTT GGACCCTCCC TTGAATGCAG TTATACCTAG TAAACCTGAT CCACAACCAA GATCCAAGAC TTTTTTCCCA GCAAATTTCA CTTTGGCCTT TGTGAAATAA GCCAGGAGGT CAAAGGTACA TTCCCAGATT TTTAAGCCTC CCTCATAAAC ACCTGTAATC AGATCAGAGT GAGAAGAAAA GCTTTTTGAA ACTATGTTTT CTCCAGGGAA GTTCTCTTTC AACAAGATGG TTTTCACTAC TGATAACTTA ACATGCTGGA AACCTGGTAA TGTTTCTATG ACTTTATTTT CTAACATCTT CTTTAAATCT TTAGGCATAG CATGCTCTTT GGCAGCTCTC AAGGAGGGCT GTTTTCCATG TGGCTCCAAG TTCCTTGAAC TGCTGGCTGC ACTGAGTGGA CTGTCTGTGT CTTGAGAGGG AGCTGCATTT TCCATTGACT TATGTTCCCA CAAGTGATCC TGAGGCAAGT CAAATTGTTC TGCAGAACAT TTTCTGTCCC TCTCTTCTCC TTTTTGACTT TCTGAGACTG ACAGCTCTTT TGAGGAATCC AGGGTCAAAG CTCCATCTCT AATGGGTGTT AATTCATTTT CCAGATGGTC TTCTATAGTG AAATTAAACT GAAAGGTCAT CCTCTTATTA AATGCACACA ATCTTTAAAT TCAGATTCTT CAACTTCTGG ATAGAATTTG ATGATACACA CAAATCTGCC TCAATTATTC AATTAGTTTT GTTGGGCCCA ATTTCTCTTT AGCAGCTTAT ACATGGTAAC AAATATTTAG AGATATTTCC AAATGACTTT TTAGACGTCT TTGGTCCTCT TTCCAAGCAG CTCTGGAAAG AAAAAAAAAA AAAAAAGAAA GAAAATGATG ATTAAAGCAA AATGGCACAT TTCACTAAAG TGTAATATTA AACAGCCACC CCCACCCCTC CCTGTCCCAC CATACAGCTG CTTTTTCTTA AAAAGTTGTG GGGAAGAGAG AGAGATAAGA GATTTGGACA CTCATACACA CCTTAAGGGT TCCAAAGTGG GAGAAGAAAA TCAACTATAA AAACAAACAG AAGAACAACA GCAACCACCA CCACTACCAC CTGGACAAAC ATAAAGTCCA AGATATTCAG ACAGGACAGC CTAGCTACTT GCTGTCTTTC AGCTGTCTTG ATTTGTGTCC AACCATATTC ACCCCCTAAG CTTCCAGAAT AACTTCACTT CTGTCTTTTA CAGAAGAGGT GCAGTATTTT ATTTTGGTAA GTCAGCGTCC CTTTAAAAAC ATGCATAGGT ATGGCCTGGT GTGTGTAAAT TCATCCAAGA CTTCACTCCA AACATTTAGT CGAGAACAGC AGCCCTAAGT GTATAGAAGT GGGGGTAATT TGGCAATAAT TAGTAAAGAC TAATTCGGTG GCAGAGCAAA CGCAAACTAG GGCACTGCAG TAGTTTGGAG AGACCTGTAG AAATAAGAAG CAACTTTATT GAGAATCTTC TATCTACTGC GCTAGACACT ATACCATCTG CCTCAATTTT CACAGTTCTG GCAAGTGGGA TCTTTGTTCC CTTTATACAA GATTTACAAT TTGGGGGAGA GGCGGGTCAC CCAGTCCCGC GGCTAGGAAC GCGCCTCTTT CCTCTCCCAT CACGCTGCAA GGCTTGGAGT CACTTCCGGC TGCAGGTCCC GGAACAAATC CGACCCCAGA AGTGGGGACT TCTGGCCCTC ACCTCCCCAT TTGAATGTAA TGTTTACAGT GATCCAGACC TGGGGATGCT TGCTTCCCGA CGTGTCCTGG GATCGCGCTT CTGAAAAAGC TCACCTCACA ACGCCTCCTC CGGACCTAAA TCGCGCACCA GTGAGTCGAG TCCTCCAGGG GCTAGAGAAG CCCGACTTTC TTTCCGGCCT TGAGGGACCC GGGCTCACCA AGAAACCAGC CGCCCTCCTC TCTATGGTTT TGGAGCCGGC GGAGAGCGCG CAAGGGTTGG CGGGACTGCG AGTTTCCGGT CTGGGCTTTG GCGGGTCTGG TTTGAAGCTC TCCTGTTTGA CGAAAGTATG TCTCAGGAAG GTGCGGTCCC AGCTAGCGCG GTTCCCCTGG AAGAATTAAG TAGCTGGCCA GAGGAGCTAT GCCGCCGGGA ACTGCCGTCC GTCCTGCCCC GACTCCTCAT ATCCTTCCTT GGTTGTCACT TCTACCTAGA GAAGGGTGTG GGCGGGTCGC GAACCTTTCT CTTCTGTCCC TTCAGACCCA CCGCCAGGCT GGGTTATATT ACCGCGGCCT GAACCCCCTC TTTTCTTTGT CAGTGAGTGG GATGAAAAGT GAGGGACTGG AGGGGAAGCG ACAACCGTGG TAGATTTAAG TAAGGCTTTG GCCCTGGAAA GCCTCGCGGA CGTGTTCTGA CCCAAGGTTT TAGCAGTGGA TGTGGCGTTT TCTTCCATTC CTTCTTTCAG TTTTTCTGTA CTCGTTGCTT GCAATTAAGT GTAAATACTT TTGCTAGTGG ATAATGGGGG AGGCAAGGAC TGAGACCTGC GGTATGACGA TAGCTCTGGC TCTTAATAGT TTGAGGTAAA GCGAGATACT CTGAGCTTTT GTCTCCCGTA AAAAGGGTGG TGAATATGAA TAAGGGCTTT CTTAGCGTTA TAAGAATTAA AGGGCATAGT TCTGTGGTGT GAAATCTTTA AAAGATGTTC AGTAAATAAA AATGATTTTC CTCCTTCCCC TCTCAGACCT CTTTTTCTTC TTTCTTTCTT TTTTTTTGAC AAGTTCTCAC TCCTCTCACC CAGGCTGGAG TCTTTCTGAA AGAGTTCTTC CGCTTGTTGT TGGCTTTCAA CTGTTGGATT TGAGGCGCTT AGCGCCTTCT TCGTCCGGGT GCAGCACATT CTTGATTGGT CTCATGCCTT TGTGGTTGTA AATGTGCCTG GAATCCTAGC CTTTCATGGT AAACCATATG TATATGTATC TTTTTCACAA CATTTGAGCC CAGCTTTATA CAATTACACT CAAAAGAAAA AAAGTAACCT TCACTTGAGA GAATCTCAAT ACTGCACAAA bPl-109 146

TATTGTGCAG CTAAAGCCCT ATGTAATCAC ATAGAAGTCA TTCACCTAGG CATTAGCAAA ATCTCAGAAG GTGCCAAAGC CCCCTTTTTT AGTTTTTGTG TAGGTACAGA ACTGCCGTCT TCAAGGAGTT TCAACTTGAA AACAAATAGC CACCCTCAAA ACATTCAAAA ACACTTAAAC TGCGTGCATA ATGTGTGTGA GACATGGTGT TAGGCTTTGG GAGAACAGAG ACACGGAACG TGATTCCTCT TCTTCCCCAC AAGCTTATAG AGAGACTTCA TTAAGTTGAA AGTCAACATT CCCACCTAGC TTTGCACTTC AAACGACATA TTCAAAAAAG CCCAAACTTC CTCTAGTTTT CTTCATCTGA GTAAATGGTT TCACAAACTG AAACCTTGAA TCCTCTCTGT CTCACACACC CGATCAGTAA GTTCTATTGT TTCTGATTCC AAACTATGTC TTGAATCAAT CCGTTTATCT CCATCCTCAT TGCTACCACT CTGATTCCAA ACCCTTATCA CCTCTCACTT GGAGTATTAA TAGTTTCCTT GTTTCTACTC ATAATTCATT ATTCCAAAAA AGTTAAGAGG GGAAAAACAT AGATCTCGTC ATTTCCCTTT TTAAACCACT TTACCTTCAA GGTTCCAGGT GATCTAAGCC TTGCCCTTCT CTCATACCTA GTTAATTAAC TACACTCTGT TCATGAATAC ATTAGGCTCA CCTACCTCAA GATCTTTTTG CTCAGCCTGA TTTGTTCTCT CAGCCTTTTG CATATTTCAT GTTTATGTCT TGGCCCAAAT GTCACTTCCT TAGAGGGGCT TTTTCAGAGC CTTCAATCTT AGGCAGTTCC CCCAAACGCA GTCTTACACT TGTATCACAT TGGCCTGTTC AGTTTTCTAA AAAGCACATT ACCATTAAAA GAAATGCTCT TGTTTGCTTT GTATATTTTC CACTTCTACA CATTATGTTG CAAAGTTCAT AAAGGCAGGA TGTTGATTTT CTTCACAGCG TTACCCTCAG CACCTAGAAC AGTGCCTGAC ACATAGTAAG CATTCATTAA AGGGCTAAAA ATATTTCATG TTTTAAAAAT ACTTGGGAGT CTAATTAGAC AATACTTTTT TTCAGCTTAA TGGTAGTATT TTAGCTTCAC TATTTTAACA AATGAAAAAT TTGCAATAAA TCTACAATGC CATTACCCCC CAAAATCTTT TTCATGTTTT GCATTTTACG TATTATTTTC CAGGCCTTAC CTGCATGTCT GCATAATCAT AACTGACTAA TTTTGGAACA GCTGGTAATT ATTTGAGCTT TACTGAAATT TTTTCATGAG GCCAATTCTA CCCTACTGAA CTCAAATTTG AGTTAATGAT GACCTCATTT TGATTGCTGC TGTAAAAAAT AAGATTTCGG AAGAGGAATG AATTCTTGTA TTACTGTGGT AGGACTATGG GTTTTTTTTT GTTTGTTTGT TTGTTTTGAG ACGGAGTCTC ACCCTGTCAC CCAGGCTGGA GTGCAGTGGT GCGATCTCAG CTCACAGCAG CCAGGTTCAA GTGATTCTCC TTCCTCAGCC TCCCGAGTAG CTGAGATTAC AGGCACGTGC CACCATGCCC GGCTAATTTT TTGTATCTTT AGTAGAGATG GTTTCACCAT GTTGGCCAGG CTGGTCTCGA ACTCCTGACC TCGTGATCCG CCTGCCTCAG CCTCCCAAAG TGCTGGGACT ACAGGCGTGA GCCACCGTGC CCGGCCGGGT TATTCATTTT TCTTATTAAC ATTCTTTGAT GATTCTTATG GTGTTGTTAC AGTAAAACAT TTCTAACAAT TATTCTAACA ATTATTCTTG ATGGTGTATA TGAAGAATTT ATTGTCGTGT ATTTGTAAGC TGCTATGTGC AGAAGAATTT CAGTCAAATA AAGTTGGTAA GATAGGTATG TAAGTAATAT GAAAAAAGAT AGAAGGTGAT GAGTGACTTA GGTATAAATT AAGTACAATA GAAATGTTGA GGAAAGAAAA ATTTCTTGTA ATAGAAATCG GAAGTACAAA CTGGGCATGG TGGTGTGCAT CTCTAATCCC AGCTCCTTGA GAGGCTGGTA TGGGAGGATC ACTTTAGCCC AGGAGCTTGA GGCTGCAGTG AGGTGTGATC ATGTCACCGC ACTCCATCCT GGGTGACAGC AAGACCGTCT CTCTTTTTTT TTTTTTTTGA GACGGAGTCT CGCCTATGCT GGAGTGCAAT GGCGCGATCT TGGCTCACTG CAACCTCTGC CTCCCAGTTT CAAGTGATTC TCCTGCCTCA GCCTCCTGAG CAGCTGGGAT TACAGGTGTG CGCCACCATG CCCAGCTAAT TATTTTGTAT TTTAAGTAGA GACGGGTTCT CACCATACTG GCCAGGCTGG TCTTCAACTC CTGACCTCTT GTTCGCCCAT CTAGGTCTCC CAAAGTGCTG GGATTACAGG TGTGAGCCAC CCCACTTGGC CCCGAGCGAG ACCCTCTCTC TAAAAAAAAA TAAATAAATA AATCATAAAC CTGTGGATTA TTGTAGCATT GTTTCTCATC TGTCAAAAAT ATTTCATGAC TATGCATAGT TTGAAAAGGC AAGTTTGTCC CTGGGCAATT TTCAAAATAT TTCTTTAATG TGTTTTCACA ATACTGTTTA CCTAATAAAT CTTAAGTTTT TAAAAGCAAA ATTAAGCCAG TAATTTGAGT CCAATTCCAA TCTCTTATGA GTCATTGCTT AAATTTCAAA AGGGTTTTAT TTTTTTTTTA GGTTTGTTCT GAGTAATGAA TACCCTATTA CTATGATACT AGTATCTTCC TTAATTATCC TACTCATTGT CTCAACATTC TGACAGTTGG ATTGAGCATA TTCGTAAGTA AAATTGTTTT AACTGTATGA TGTACTTTGA TGTTAAGGTC CGAGTCCCCA CATACCTCGG TAGATGTGTT CTTACAGTTT TGTATTCCCT TGAAATGTAA CTGTTCTCTA TGTTACAGCC TTTATAACCT TCAGTTACTT GAAATGAACA AATTCATTCA AATTCCAGCA CTTAAAAGTT TTAAATTACA TTTTGGATAA ATACCAAAGT GTTTTGTTGA TGATGTATGT ATAAACAAAT TGTAAATATT AAACGTTAGT TGTTACGATT AGACCTATAT AAAACATGAT ATGCAGTCTA CTGAATAGCT ATCAGCCTCT AACATGTTTA GTGTCATTTA GAAAATGCTT TCTAAATTGC CAAAAGCTGA TTGTCTAGGT GATAACAAAT TTACCATTTG GAGGAAGTTG ACTTTCTCAT TTTCATGTCT TCATCAGTCT TACTTGATGA GATTCATTCT TCTAGTCAGA AGAGAGTTTA GACTGCTCAG TTTACTCATA TTTTGAGTTA GCTTTTCTAT TTAGAGTTCA CTTGGTTGTG GAATATTCAT TTATAATTTG AATCTACGTT GTGTAATGGG ACCTAATTTT TTTTTCCTTT GTTTTTGTTG GAGTCTCGTT TTGTCACCCA GGTTGGAGTG CAGTGGCGTG ATCTTTGCTC ACTGCAACCT CCACCTTCCA GGTTCAGGTG ATTCTCCTGC CTCAGTCTCC CAAGTAGCTG GGATTACAGG CATGCTTCAC CACGCCTGGC TAATTTTTGT ATTTTTAGTA GAGATGGGGT TTCACCATGT TGGCCAGGCT GGTCTCAAAA CTCCTGAGCT CAAGTGATCC TCCTGCCTTG GCCTCCATAA GTGCTGGGAT TACAGGCGTG AGCCGCTGAG CCTGGCCCCA GAGTTTGTTT TGTTTTGTTT TCAAGACAAG ATCTCACTCT ATTGCCCAGG CTGGAGAGCA GTAGTGCGAT CATAGCTCAC TGCAGCCTGA ACTCCTGGGT TCAAGCTATT CTCCTGCCTC CATCTTCTAA AGTGCTGTGA TTACAGGTCT GAGCCATGAT GCTTGGCCTG TGTTTTTGTT TGTTTGTTTT GGGGGACAGG GTCTTGCTTT GTCACCAAAA CTGGAGTGTA GTGGTGCGAA CATAGCTAGC TCACTGCAGC CTCCATCTCC CACGCTCAAG CAATCCTCTC ACCTCAGCCT TCCAAGTAGC TGAGACCGCA GGTGCGTGCT ACCATGCGTG GCTAATTTTC TATTTATATA TTTATTTTTT GGTAGACATG AGGTCTTGTC ATGTTTCCCA GGTGGTCTTT AACTCCTGGG CTCAGACAGT CCTCCCGCCT CAGCCACCCA AAGTGTTGGG ATTACAGGCG TGAGCCACCA TGCGTGGCAT AATTTTTTTT AAGTAAATTA TTTTTTTATC TTGAGTATAG AAGTGATTCA TGTTCATTGT GGAAAATATG AAACATATAG AAAAACAGAA AAGATTACAA AACATCTAAT CTGAAATGGT TAAGATTTTG ATGAGAACAG TCTCATCTCA TTTCCGTATA TTCCTGCCAG CCTATCCATC ATTCTTCGTA CATGTTTATC TACATTAAAA TTGGTGTTAT ATTTTGGAAA CTTTTTGTTT AACTACATTG TGAACATTTT TCATGTTTTA AAATGTCATT TTAATGATGG CAGATCCTAT TCAATAGATG TACACACACC TATTTAACTG GTCCACAATT GTTGGATATG TAGGTCGTTT CCTTTCTCTC TTTTTTTTTT TTTTTGGCTA CTACTTAATA GTTTCTCTGT ATAGAATGTG GTATTTTGAA AGTGTATCAA GCTTTAGATT GGTAGTATTC TTGCATTTAA TAAAGGGCAG TGGCCTTTGT TGACTGACAT GACAATATTT TTATAAAATT TGTTATTTGC TTTACAGAAA TTTTGAAAAT TATTGTAGAA ATGTTTTTAC CTCATATGAA CCACCTGACA TTGGAACAGA CTTTCTTTTC ACAAGTGTTA CCAAAGGTAT AATACTATTA CCTGAAAATA CATGTTATAA GGAATCTAGC CTCAGTCTTA GATGATTTAT TATTAATTAT GGCTCTCTTT TTCTAATATA TCAAATATAT TCAAAATAAA AATAAGGAGT AAGTAGATCT CATGTGAGAC TATAATGGTG TTAGTGTGAT CATTAGGCAG TTAAAAACTG TTACAGGCTG GGCACGGTGG CTCATGCCTG TAATCCCAGC TCTCTGAGAG GCTGAGGTGG GCAGATCATC TGAGGTCAGG AGTTCGAGAC CACCCATGGT CAACATGATG AAACCTCGTC TCTACTAAAA GTACAAAAAA TTAGCTGGAC ATGGTGGCAG GTGCCTGTAA TCCCAGCTAC TTGGGAGACT GAGACAGGAG AATTGCTTGA GCCTGGGAGG CGGAGGTTGC ATTGAGTCAA GATCGTGCCA TTGCACTCCA GCCTGGGCAA TAAGAGCGAT GCTCCGTCTC AAAAAAAAAA AAAAAAAAAA AAGAACTTAT ATTTTCAGAT TGTGTGGTTC CTTTACTAAC TGAATTTAAA TTATTTGTAG TCAATTTTAA ATGCTCTTGT ATTTTAAAGC CACTGTACTC CAGCCTGGGT GACAGAGTGA AACCCTTAAT TCAAAAAAAA AAAAAAAAAA EPI-109 147

AAGAAAAGCT GGAATATTGG CAAAATCAAG TAACTAAGAG AAAACATTAA ATTCACAGAA TACATTATTA CATTTTAGAT ATATATGGTA TATGTTTTCT CTGAAAAGCA CAAGCATACC TTTTTTGTTT TAAATGGAGG GAACTAAAGA TACTTTGGTG CCAAAATGAA ACATTATTTG TAATTAATCT CTTATTGAAA TGGGTTTCTA ACTTTAGCTT TGAATCGTAA TCTTTCAAAT TTCTTGTACT CATAGTCACT TGATGATTCT CTATCTGAAA TATTTCTTAG AATTTGTTCT TGACCACCAG AAAAAGATTC AACTGTTACA TAGATGAAAA TGGATGTTGA GTGTTAACAG GCCTATGGGA AACAGTATTT TCTTTAGCTA CATTGTATTG TTGACTGTGT TGCTATTCTT ATAATGTTTA GGTCATTTAA ATTGTTAGAA AGATCCAAGT ATTAAGATCT AGGGTGGCTA ACTTTTCACA GACAAAAAGC TTGTTTGTAA GGTCATTTAC TATACCCTTA ATTCAGGAAG GTTAGCTTGA ATTGGGTCAA AAGGAAACTG GTTAGAAAAT AAGTGAGTAG TGAATAGGCG ATTCAGTGCA AATTCCTTCC AGAAAATACC CTTGTAAATG ACTGTATGAA TGTGGATTCT TCAAGACAGT CAAATTTATT GTGCGAAAGT AATACTTTTA TTTTTTGCAT CTCTAAAACA TGAACTTTGA GTGATTTTTT AAAAAAATTG ATGCTATTAA ATAGATTCAA ACCATAGAAA TGGAAAATAA ATTTCTGTTT GGGGCTTTTG GGGGGATTAT GTTGTAAAAA TACCTTTTCT CTGTATTTTG TGCTTAATTA GGTACAATTG TTAAGCTAGA TGATAGCCTG TGGATGTTAC TAGTGCAAAA TCAAATTATC GTATTGTGTT TTCTCTGTAA AGTTTTGTCT TGTCTTTTCT AGTGATTTCT CTTATTCCTG TTTATTACTT GATTTGTTTT TACAGACTGT GAAATTATTC GATGACATGA TGTATGAATT AACCAGTCAA GCCAGAGGAC TGTCAAGCCA AAATTTGGAA ATCCAGACCA CTCTAAGGAA TATTTTACAA GTAAGTCAAA TGTATTAGAA AGCAGGAGAG AGAGGGAGCT TAAAGAATGT CAAAATTTTT ATACTGATAC TGATTAGCTA TGTATTCTTA TGTAATGGCC TAATGTTGGA ATTAAATTTA TAGAATTAAA GACGTGAATA TAGAAACATG AATTCTGAAT AATAAACTCT TATAAGAAGA GAAGTCATCA AGCTAGCTGA CCCTACCTGT ATTTTCAAGG ATATGTGTGG AACACCTGCC ATGTGTTTTG AAGTTTGTGT TAGTATTCTA AATGGCTAGA CAGTTGTTCC AGTATTTGTA GTTCTGATAG ACTAAAGTTC TGTGAAAAGA GGAAGAGACT GTGTTTTGTT CATTGCTGTA TTTGTAGCAC CCAGCATGCT GACTAATACC TTTTCAGTGC ACAAAAAATA TATTCTAAGT GAAATTTCCT TCCTTATTCA CAGACAATGG TGCAGCTCTT AGGAGCTCTC ACAGGATGTG TTCAGCATAT CTGTGCCACA CAGGAATCCA TCATTTTCGA AAATATTCAG AGTCTCCCCT CCTCAGTCCT TCATATAATT AAAAGCACAT TTGTGCATTG TAAGGTGAGT AAAGGTCTAA TTATACTTTG AATGGTATAT AATCAATGTG CATAGGGGCT GAGTAAAATA ATGTTTGTAT AAGATTTTAC ATTTTAGTCT ATATTATTGA AATAAACTTT TCCATAGAAT AAAGAACATG TAAGTAAATA ATTGTTGCAA AAAAAGTGGT TTTAAGGAAG TCATTAAAAG TGGCTTTTTG GGGTTTTTTA GTTTTATCTT ATTTCCCCTC TATAAAGAAA GAAGTTTTAA GAATTTGTGT TGAGACAGAC ACAGGGATCC TGAAATAGTT ATGTCATGTT GCATTGACCA ATATTCAATT ACCATTATGA TTAGATGTCA GAACTTCCTT TTATAAAGGA AAGTTAATCC TTATTTAGTC CATCTCTACA TGCCAGAGGT AGCCTTGAGG CACAAAAGCT TGCCTAGAAT TTATGGGTCA CAGACAGTTT TAATATTGCT ATTTGTTGGG CGAATGAAAA TCACTAGTTA ATTAATACCT CTCTTTGCTG ATAGGATGCT AAAAATGTCA CGCACCTGGC CTAATGTTAC CCTTTTTTAG TTCTGTATTT GCAAGATCAT GGAAGTCAGA AATAATATTT TATACATGCT TGCATCTCTT GAAGCACACT ATATTTAATG GATGTTCACT AAACAATGAA TGAATATGTG ATTCAGTAAA TTTATGATCT CTAATAGTAT GAATTAAAGT AAATTTGGCT CTTGAGCTTT GATTTGTTTT TTCTCTCATT TTTATTTATC CGTAATCAGA ATAGTGAATC TGTGTATTCT GGGTGTTTAC ACCTAGTTTC AGACCTTCTC CAGGCTCTTT TCAAGGAGGC CTATTCTCTT CAAAAGCAGT TAATGGAACT GCTGGACATG GTTTGCATGG ACCCTTTAGT AGATGACAAT GATGATATTT TGAATATGGT AATAGGTGAG TGAAGAAAAC TTTCTGCTTA GTATATGGTG ACTATAAATC ATGTATCAAT TAAAATTGTC TCTAATGATT CATGTTATTT TCTTACTAAT TATGCATTAA AATTGATTTA AATCTTACCA AATAAATTTT TAATCTTGAA ATTTGGAATT TGTAAAATTT ATTTTGGGTA CCTTAACCTA GATTTGCGTA TTTAGTTACT GTAATTTCTC CACAATGATT AACTTATATA ACTTTATAAT CTCTGAGGTT GTCCATATTC AGAGACAATA ACTTTCACAT TTTTTTAACC ATAACTGATA TTGAGATGCA GTTTATATTT CCTTCCAGAA TACATATAAA TACGTGCATA TGTGTATGTA AATATGTCTA TTCTCATATA CATATTATAA TGAAATAACT CATTTTACAT GTGATGCACT TTATACTAGT TTATTTTTAT TTTATTTTAT TTTTTTGAGA CAGAGTCTCA CTGTGTAGCC CAGGCTGGAG TGCAGTGGCA CAATCTCGGC TCACTGCAAC CTCGCCTCCC GGACTCAAGC GATTCTCCTG CCTCAGCCTC ATGAGTAGCT GGGATTATAG GCGTCCGCCA CCACACCTGG CTAATTTTTG TATTTTTAGT AGAGACAGGG TTTCACCGTG TTGGCCAGGC TGGTCTTGAA CTCCTGACCT CAGGTAATCC ACCTGCCTCA GCCTCCCAAA GTGCTGGGAT TACAGGCATG AGCCACCGTG CCCAGCCAAT ACTAGTTTAT TTTTAAAGAA TTGCTGGTCG TAACACACTT CATTGATTTT ATCACTCATT AATGGATTAT GAACAAGAGT TTGAAAAACA ATATAAAGGC AAAGTTTGCA TTCAAAACTT TGGTATAAAG AGAGTAAGTT GGTTTTGTGC AGTGTATCAG GCACCTGTTG CTCTGCAACA CACCACCTCA AAATCTATTT ATTCACTATT TATTTATTCA TGATTCTGTG AGTCTGCAGT TTAGGGTGGG ATGTCCTGAG ACAACTTTCT CTGATCCACC TGGGGCACTA GCTCACCCAT GTGACTTCAG TGACTTCATT CACATCTGGC TGTTGGCAGA GGCAGAAGTA CTTGAGAAAG CCATGTGCAT CATCCAGCAG GTTCACCCTA TCTCAGATAC CTGATGCCAG TGGTTTCAGG GTTTCTAAGA GTAGCAAAAG TGTGAGCAGG TCGCTGTGTG CTAGCACTTT TCAAGTTTCT GCTTGCCTTA ATTTTATTAT TGTCCCCCGG GCCACAGCAG GTCATAGCGT TTAGCCCAGA GTCATTGTAG AAAAGTGTGG ATTCACAAAG GGCAGTCATT GTGGCCATTT TTATAAATAA TCTACCACAG ACTGAGTAAA AGCCTTGCAT GAATACCATG GATATTAATT TGAATTCTTC CTTTTTAGAT TTTCTTTCCT TAGCAATTTG TTTTGTCATT TTGGATTAGA ATTATATCTG TAGAATATTT CAGTTATAAT AGGGTACAAC TTTTATTCCA CTGAACATCT TTAGTTTTAT TTAGGTCATC TGGTAGGTAT AAACTTCAGA AGTTAATATT CAATATTTAT AAAAACCATT AACAAGTGTG ACACTTAAAT AGTTTAAATA ATTCTTTTGA CACAACTGTT TCCAAGTTGT GTTACGTATT TTAATTCAAT CAAATGTTGA AATTGTTCAG TAGATAGTTT TAATTATAGG AGAAACTCAC CCCCATGACA TTTGGATGTC TTAAAAGTTC TGTTATCTTT CTTTGCAGTT ATTCATTCTT TATTGGATAT CTGCTCTGTT ATTTCCAGTA TGGACCATGC ATTTCATGCC AATACTTGGA AGTTTATAAT TAAGTAAGTT TGTTTGTTAT TTTTTACTTT TTAGAAAATG TTTTCCATAT TCCCCAATCT TAATTATTCA TGATTCTTTA GATTGCATTT AAAACATTTT GTGTGAATTT AATGTTCACT GACACTGCTG TCTGATAATC CAGATATTCT ACATGTAGCT CTCAAGCCAA ATTGGACTTC TTTACCCTGT GGCCTCTAAA ATTAAAAAAA ATGTTCTTCC TAGTTAGCTA GTACTTCAGA AATAATGGGC CATGGGCCAG ACTAGAACTT AACCACTTTT CTTCTGCTAC TGTTGTTTAA CCAGCTATCA AGTATCCTAT TTCTAGGATT AGATAAATTG ATAACTATAA TTAAAACTGA ATATAATCTT TTCATTAGGT ACTTTTAAGT TGTTCACACT TAATTCCATT TGTACAGTAA TTTTAACTTT CTGAAACTGA AGCATTTTAA AGGGTCACCA GGGATAGTGC CTGTAGCATT CATCAGATTC TTAGGGGTGA GAGGAGATGT GGTTGAGATG TAAAAATGGT TAAGAATATC TACTTTATAC ACATACATAA AACATTAAAG GTCAGTGTAT TTTCAGGTCT TAGGTACTTT TCTTGTACTA CCAGGACATT AAGTTGCCAT TCAGTGGTTA AGAGTGTTGC CTGGGAGCTG TATCACATGT GCTTAAATCC ATTCTTGAAA TCATTTACTC CTTCTGAGCC CTTGGGCTAT TTGGTTAATT TCTCTGAACG TTAGTTTGCT CATCTGAAAA TGGAAATAAT AATAGCAACT TCTTGACAGG GTTATAGTGA GAATTGAGTT CATCACTGTG AAATGCTTAG AAATGTGCAT GACACATAGT TAATACTCAA GGAATTAGCC ACATCACTAT CATCATCACT GATTATCTTC CACTCTTACC CTCTTCCAGT TCATTTTCTG CCCAGCAGAA TGATCTTTTA AAAAGTAAAT CAGATCATGT TACTCTATTG CTTGAAGTCT ATCCCATTTG ATTAAGAATA ACAACCTAAT CCTCTGTGGA TGCTGCCTCC TTCACCAGCC EPI-109 148

TGTCTCATGC TGCTCTCCCT ACTCTTAGTT CCTCAAACAT ACCAAACTCT CCTGTCCCAG AGTCTTTTCG TGGTTTTTCC ATCTGCCTAG GATGCTTCTC TCTCCTATTT TGTGTACCTT GCTAACTCCT GCTTACTGTC TTTCAGTTCT CAGCTTAAGA GTTATATCTT CATGATAACA TTCTTTGATA TCCTTACCCT AAGATTAAGT TAGATTGATA TCCTTACCCT AAGAATAAGT TAGATTAGGT CTCTCTATTG TAGCACCTTA GACTCTGTCA TTTGACAAAT CACAGCCCTA ATTAATTATT CTTAAAATTA TTTAACATTC TCTCTCATGC TAGACCACAA GTTTCATGCA GGTAAGGCGG AGATTGTGTC CATTTGTTTG ACCCCTTTGT CTCCAGGGCC TGGTAGAATG CCTCATACAT AGTAAGAATT CAATTAATAT TTTACACAGA GAAAAAATTA GCAACTTATT TAAACAAATA TAACTGCTTC AGAGGTAAAC TGGGCACATC TTAGTTATAT TATGTGATAT ATGATGCTTT TTGATTGTTT TTTTAAATGT TCTACAAGGT AGATATTGTT AGAGGTCCTA AGTTACTTGA TGTGTTACTT GTGGTGATTG TATTCTTTTC TTTTTATTCA TTTAGGCAGA GCCTTAAGCA CCAGTCCATA ATAAAAAGCC AGTTGAAACA CAAAGATATA ATTACTAGCT TGTGTGAAGA CATTCTTTTC TCCTTCCATT CTTGTTTACA GTTAGCTGAG CAGATGACAC AGTCAGATGC ACAGGTAAAA TTTGGGCTAA TAGCATTTTA AACAGCAACT CTTATTTTCT TTGGCAGTTA GTAAATCTCA TTTGAATGTC TGGGTCAGTC TATTTAAGAG GATTTTAATT TATTTCATTT GGGTGTTTTT TTTTGATCTG TGGGATTATT TATATCCCAT AATTACTTTT CACCCAGAGC ATTGTATTAG ATTCCTAACT GCTGTCATTG CCTCTGGGGT CTGCCTGGCT CCCTCTTTGC TTGGTAACTG GTTGGTCACA GCATTCTTCT CAGAATCCTT TCATTCTTTT CTGCATGAGA ACAAAAATTC TTTTGTTCAT ATTTGTATAA GATCTGATAT AGCTGCAATC AATCTTGCAT TTTTTCTTCA CCAACGCATT GCGACCTTTA GGGATACAAG TATGTTTGTG CATGTATATG TATGTATCAG TCTTTTAAAT TTGATATAGT CATACATTTG TTTTTATTTT GAAAAGTTAG AGTGTTGAAT TGGTATCCCA TTTATGAAAC ATTATATTCT AAAAATTTGT AGTACGATTA TTGGGAATTA TAACTCATTT TCCTGTAACA CTGTTATACA TAGTACCTTT TGCTTTCAGA CTAGCCCTCA ATTTTATTTA ACTATAGTAG TCCTAAATTA TAAGATTAAT AGTACTCAGG ACCTAACAGT TATATGTCAT TTGTTTTTTT TTTTTTTGAG ATGGCGTCTC ACTCTGTCAC CCAAGCTGGA GTGCAGTGGT ATGACCTTGG CTCACTGCAG CCTCTGCCTC ACGGGTTCAA GGGATCGTTC TGCCTTAGCC TCCTGAGTAG CTGGGATTAT AGGCGCCTGC CACCACGCCT GGCTAATTTT TTTAGTAGAG ACGGGGTTTC GCCATGTTGG CCAGGCTGGT CTCGAACTCC TGACCTCAGG TGGTCCACCC GCCTTGGCCT CCCAAAGTGC TGGGATTACA GGTGTGAGCC ACCGCGCCCA GCCTATATGT AATAATTTTA ATGGGACCAT GAATTGAATA TTTCTTCCTT GAATAGCAAT GACATAGCCC CTTCTATTGT ACATCTGCAA GCTGATACAG GGAATTCCTT TGTACCTGCG CTCTTCCCTG CCAGTCAGCT ATGGGGGTGA AAGTGTAGGG GTTCATCCAA GTCCTAAAAC TGGTAGCAAC TCCTAGGGCA GGGCTGATCT GGAAGGACAG ACCCTAGGGG AGGGTGGAAC TTTAAAAAGA AGTTCTGAAG GTAGTAAGAA GGAAATGAGG AGTAGTGTTA GGAAGGGGCT AACΓTTTTTC TTCTTGCTTC TCTTCTTTAT CTCACCTGCC CCTCCCCTTG TATCCCTTCT TCCTTTTTCC CTTTCCTTTT TTGTCCTCAC TTCATTCGTG CATCCTTTCT GATTCCTCTT ACCTTGCTAA AAGGAGAAGT TTGTTTGGGT ATCCTATATC AATGGCAGGA AGGTTGTTTT CTTCTTTACC TTTATCCTAT AGATTCATAT TCTCAACACC AACCTCCTCC TTTTTCAGTT TCCTTCTTGC TTCTCTTGAC ACCACAGAGT TTGCAGCTAG TACTTGGAGA GGAAAATTAA ACAGAGATAC TTGGACCAAG AGTAAGATGA AGAAAGTCTA AACAACAGTA TAGTCTATAG TGGCAAGAGA GAGTATGGGG GCTGCTTAGC CAGGGTGGCT GTACATAAAG TATATCTTCA GTTTATATAA ACTGCTTATA GATGGAAATC AGAAAATTTA AATTCTCTTA ACTGTCCAAG AAAATTCTCA TTTTTTCAAA TTTGGGACTG ATAAATGTGA CCAGTTCTGC TTACTGTCCA TTGCCTGAAA TGGAGCTTTG AGGTGGACTG TATAATTTCT TCAATCTTAA CTCCAAATTC TGATCAGCGA CGCCCTCTGC TGTTCACTAT TAATATTTAT TTACCAATCA AAGTAAAGTA TTGAAGTTTT CCTGGCAGTT TTCACTTTGT GTTTTAGTCC ATTTAGGCTG CTATAACAAA ATCCCTTAAA CTGGGTAAGG GATTATAAAT ATTAGAAATT TATCTCTCAC AGTTCTGGAA GCTGGGAAGC CCAATATCAA GGCACCAGTA GATTTGGTGT CTAACGAGGG TGTGCCGTCT GCTTCAAAAA TGGCCCCTTG TTGCTGCATC CTCACTTAGT GCAAGGGGCA AGACAGCTCC CTTCAACCTC TTTTATAAGG GCACTTATGT CATTCATGAG GGCAGAGCCC TCATGACTTA ATCACTTCCC CAAAGGCCCC ACCTCTTAAT AGTATCACAT TGGGTGTTAG GTGTCTGGGA GGACACCAAT CTTCAAGCCA TATCATCTCA CTTGGAAAAA AGTCAAAATA AAACCAGTAG ATTTAATTAA TATTACACTA TTTATAGAAG CATGTGATGT ATCATTCCTT GTATTAATTT CCTGGGGTTG CCGTAACAAG TTACCACAAA CTAGGTGGCT TAAAACAATA GAATTTTATT CTCTCACATT TCTAGAGGCA GAAGTTCACA GTGTGTCAAT AGGGCCATGT TCTCTGGAAG GCTTTAGGGG AGAATATATT TCATATCTTT CTCTTAGCTT CTCGGTGTCA CTGGCAATCC TTAGCTTACT TTGGCTTTCT GTGTCTTCAC ATCATCTTTT TATAAGAACA CCAGTGATAG TGATTAAGGG CATACCTTAC TTTAATATGA CCTCATCTTA ACTAATTATG TCTTCAATAA CCCTATTTCC AAATAAGGCC ACATTCTGAA GTATTGGGAG TTAGAACTTA AAGCTTTTTG GGAGGGACAC AGTTCAACCC ATAACAACCC CTAAAATCGA TATTTATTCT CAATTAAGTC TTGAAATTGG TTTCAAAAAG AGAATATTCT ATTAGAGTTT TTAATGTATA GTTTTAACAT ATAGTTCTTT AGCCCCCAAT TTTTTTTTTT TTTTTTTTTT TTTTTTTTTT TTTTTGAGAC GGAGTCTCGC TCTGTCGCCC AGGCCGGACT GCGGACTGCA GTGGCGCAAT CTCGGCTCAC TGCAAGCTCC GCTTCCCGGG TTCACGCCAT TCCCCTGCCT CAGCCTCCCG AGTAGCTGGG ACTACAGGCG CCTGCCACCG CGCCCGGCTA ATTTTTTTGT ATTTTTAGTA GAGACGGGGT TTCACCTTGT TAGCCAGGAT GGTCTCGATC TCCTGACCTC ATGATCCACC CGCCTCGGCC TCCCAAAGTG CTGGGATTAC AGGCGTGAGC CACCGCGCCC GGCCTGCCCC CAATTATTTA GTTTTTCTAT AAACAGGGAA ATTTATTTGT GTGGCCCTTA GAACTAATTT AATTTCCACT CTAATTCCTA CTTATGTTTA TATAATGCTT TTAGAAATTT GTATTATTCA GAAAATAAAC ATATACTATT GTATCTGTTG CCTACACTTA GATTTTATTG CCTGCTATAT TTAAATTTTA TTAGTATTTT AATTGTTTTA TTAAAGAAAG AATGTGCCTG TAATCTCAGC ACTTTTGAGA GGCCAAGGCA GAAGGATTGC TTGAGCCCAG GAGTTTGAGA CCAGACTGAG CAACACAGGG AGACCCCCAT CTCTACAAAA AATAAAAAAA TTCTCCAGGC CTCATGGCAC ATACCTGTAG TTCTAGTTAC TTGGGAGACT GGGGTGGGAG GATGCATTGA GCCCAGGAGA TTGAGGCTGC AGTGAGCCAT GATCAGGCCA CTGTACTCCA GCTTGGACAA CAGAGTGAGA GCTTGTCTAG ATAGATAGAT AGATAGATAA TCTAAATAGA TAATAGACAG ATTATCTAAA TAGATAATAG ACAGATTATC TAAATAGATA ATAGACAGAT TATCTAAATA GATAATAGAC AGATTATCTA AATAGATAAT AGACAGATTA TCTAAATAGA TAATAGACAG ATTATCTATC TAAATAGATA ATAGATTATC TAAATAGATA ATAGATAGAT AGATTAGATA GATAGATAGA TAGATAGAGC TTGGACAACA GAGTGAGAGC CTGTCTAGAT AGATAGAAAC AAAGAAAGAA AGAAAGAATG GTGCTCATAT TTTAAAGCAT TGAAAAATGG TCTTCCTTGC TTATATTACC CACACCTTCT TTGTTGGCAT TAAGATGCAA ACTTTGTTTT AAACAGTTGA GTAAATCAAA GATGGGACTG TTAAGTTATT TGTGTTATTT ACCTGCTTTT TGAAAATGTA AAAATAAAAC TCTAGGTTTA ATTAGTAGTA TGCTATTTAG TAATGAAGTA AAGCTAGAGG CTTCGAACAA ATCTTGTGTA ATTTCCTCTT GAATGAGAGA GAAAATTTAA AGTAAGCAAA CAAATAAGTT GTGTGTCACC ACTCATTCAG TCATTTAACA AGTATTTCCA GAGTACTTAT TCTGTGCCAG GAAATGTTGT AGGTGCCCTC AACAACTTAG AGTCTAGCCT GAGACACAAG TAAGTAGGTA ATTATTATAG AATGGTATGA TCTTTGGAGG ACTGGGTATT GGCTGGCTCA TGGGAGTACA AGATAGGTAC CCAGTGATGA AGTCAGGAAA GGTTTCTTAT GGTGATATGA TGACGTCTAT GCTGATTATA AGGTCAGTGT AGAATAAACT TTGTGCTTTT AAATTTGCAT AGCACTGTAT TAGAGAGTTC ATCTTCAAAA TAATCGAAAA GGCTGAGTGT GGTGACCCAT GGCTGTAATC CCAGCACTTT GGGAGGCCGA GGTGGGCAGA TTGCTTGAGC TAGGAGTTCG EPI-109 149

AGACCAGGCT GGCCAACATG GTGAAACCCC GTCTCTACTA AAAATACAAA AATTAGCCAG GAGTGATGGT GCGCACCTGT AATGCCAGCT ACTTGGGAGG CTGAGGCAGG AGGATCACTT GAACCCAGGA GGTGGAGGTT GAAGTAAGCC GAGGTCATGC CACTGCACTC CAGCCTGGGC AACAGAGTGA GACTCCATCT CAAAAAAAAA AAAAATGATC AAAGAAAGGT GAATTTTCAT CTACCCTATT TCTGCTGAGG AAAATGGACT ATTTTCAAAT ATTTTTAATA AGGGTCAAAA TGAGGGATC GCCACCATGG AAACCCTTTG CCTCAGGGCA TCCTTTTGGC TGGCACTGGT TGGATGTGTA ATCAGTGATA ATCCTGAGAG ATACAGCACA AATCTAAGCA ATCATGTGGA TGATTTCACC ACTTTTCGTG GCACAGAGCT CAGCTTCCTG GTTACCACTC ATCAACCCAC TAATTTGGTC CTACCCAGCA ATGGCTCAAT GCACAACTAT TGCCCACAGC AGACTAAAAT TACTTCAGCT TTCAAATACA TTAACACTGT GATATCTTGT ACTATTTTCA TCGTGGGAAT GGTGGGGAAT GCAACTCTGC TCAGGATCAT TTACCAGAAC AAATGTATGA GGAATGGCCC CAACGCGCTG ATAGCCAGTC TTGCCCTTGG AGACCTTATC TATGTGGTCA TTGATCTCCC TATCAATGTA TTTAAGCTGC TGGCTGGGCG CTGGCCTTTT GATCACAATG ACTTTGGCGT ATTTCTTTGC AAGCTGTTCC CCTTTTTGCA GAAGTCCTCG GTGGGGATCA CCGTCCTCAA CCTCTGCGCT CTTAGTGTTG ACAGGTACAG AGCAGTTGCC TCCTGGAGTC GTGTTCAGGG AATTGGGATT CCTTTGGTAA CTGCCATTGA AATTGCCTCC ATCTGGATCC TGTCCTTTAT CCTGGCCATT CCTGAAGCGA TTGGCTTCGT CATGGTACCC TTTGAATATA GGGGTGGACA GCATAAAACC TGTATGCTCA ATGCCACATC AAAATTCATG GAGTTCTACC AAGATGTAAA GGACTGGTGG CTCTTCGGGT TCTATTTCTG TATGCCCTTG GTGTGCACTG CGATCTTCTA CACCCTCATG ACTGGTGAGA TGTTGAACAG AAGGAATGGC AGCTTGAGAA TTGCCCTCAG TGAACATCTT AAGCAGCGTC GAGAAGTGGC AAAAACAGTT TTCTGCTTGG TTGTAATTTT TGCTCTTTGC TGGTTCCCTC TTCATTTAAG CCGTATATTG AAGAAAACTG TGTATAACGA GATGGACAAG AACCGATGTG AATTACTTAG TTTCTTACTG CTCATGGATT ACATCGGTAT TAACTTGGCA ACCATGAATT CATGTATAAA CCCCATAGCT CTGTATTTTG TGAGCAAGAA ATTTAAAAAT TGTTTCCAGT CATGCCTCTG CTGCTGCTGT TACCAGTCCA AAAGTCTGAT GACCTCGGTC CCCATGAACG GAACAAGCAT CCAGTGGAAG AACCACGATC AAAACAACCA CAACACAGAC CGGAGCAGCC ATAAGGACAG CATGAACTGA CCACCCTTAG AAGCACTCCT

-3' (FRAG. NO: 1738) (SEQ. ID NO: 1749)

5'-GCCACCATGG AAACCCTTTG CCTCAGGGCA TCCTTTTGGC TGGCACTGGT TGGATGTGTA ATCAGTGATA ATCCTGAGAG ATACAGCACA AATCTAAGCA ATCATGTGGA TGATTTCACC ACTTTTCGTG GCACAGAGCT CAGCTTCCTG GTTACCACTC ATCAACCCAC TAATTTGGTC CTACCCAGCA ATGGCTCAAT GCACAACTAT TGCCCACAGC AGACTAAAAT TACTTCAGCT TTCAAATACA TTAACACTGT GATATCTTGT ACTATTTTCA TCGTGGGAAT GGTGGGGAAT GCAACTCTGC TCAGGATCAT TTACCAGAAC AAATGTATGA GGAATGGCCC CAACGCGCTG ATAGCCAGTC TTGCCCTTGG AGACCTTATC TATGTGGTCA TTGATCTCCC TATCAATGTA TTTAAGCTGC TGGCTGGGCG CTGGCCTTTT GATCACAATG ACTTTGGCGT ATTTCTTTGC AAGCTGTTCC CCTTTTTGCA GAAGTCCTCG GTGGGGATCA CCGTCCTCAA CCTCTGCGCT CTTAGTGTTG ACAGGTACAG AGCAGTTGCC TCCTGGAGTC GTGTTCAGGG AATTGGGATT CCTTTGGTAA CTGCCATTGA AATTGCCTCC ATCTGGATCC TGTCCTTTAT CCTGGCCATT CCTGAAGCGA TTGGCTTCGT CATGGTACCC TTTGAATATA GGGGTGGACA GCATAAAACC TGTATGCTCA ATGCCACATC AAAATTCATG GAGTTCTACC AAGATGTAAA GGACTGGTGG CTCTTCGGGT TCTATTTCTG TATGCCCTTG GTGTGCACTG CGATCTTCTA CACCCTCATG ACTGGTGAGA TGTTGAACAG AAGGAATGGC AGCTTGAGAA TTGCCCTCAG TGAACATCTT AAGCAGCGTC GAGAAGTGGC AAAAACAGTT TTCTGCTTGG TTGTAATTTT TGCTCTTTGC TGGTTCCCTC TTCATTTAAG CCGTATATTG AAGAAAACTG TGTATAACGA GATGGACAAG AACCGATGTG AATTACTTAG TTTCTTACTG CTCATGGATT ACATCGGTAT TAACTTGGCA ACCATGAATT CATGTATAAA CCCCATAGCT CTGTATTTTG TGAGCAAGAA ATTTAAAAAT TGTTTCCAGT CATGCCTCTG CTGCTGCTGT TACCAGTCCA AAAGTCTGAT GACCTCGGTC CCCATGAACG GAACAAGCAT CCAGTGGAAG AACCACGATC AAAACAACCA CAACACAGAC CGGAGCAGCC ATAAGGACAG

CATGAACTGA CCACCCTTAG AAGCACTCCT-3' (FRAG. NO: ) (SEQ. ID NO: 2481)

5'-GATCAAAATT TTTACCTATT ATGCATTTGA TATATAAATA AGTATATAAA TGCACACACA GACACAGCAA TGATGGTGAA CAGTCTTCAT ACAATTATAT GGATGAATCT CATAAAATGC TGAGTTAAAG AAATCAGACC AAAGAACATA TACTGAAAGA TTCTCTCTAT ATACAAAGTT CAAAAATAGG TGGACCAATT CATGGTGGTG TTAGAAATCA GAAGAGAGGC TACCTTTGTG GGGAGGGGAC AGTTTAATGC CCAGAAGCGG TAAATAAGGA ATCCTCTGGG GAGTGGTAAT GATCTGGATG CTGGCTACAG GATGTGTTGG TTGTAAAAAT GCATTTTTTT ATATCTAGCT TTTTCCATGT GTATATTATA CTTCAAAGAA GTTCAGTTAA TAATTTCTCA TGTCACTGTA GAGTAGCTCA GTTAGCCCCA GCAAGCCTCT GGCTTAATCT TGTTTTACCT TAAGCCATCA GTCATTTACA AGTAGGAAAA TTCACAGGGA AAGTTAGAGT ATAAAATCCA GAATGAAGGT TTACTGGGTA AGAGTCTCTC CATTTTCCAA AGCCCGTTTA TTTCTTGATT CCAGTTCTTA AGAAGTCTCA GCATTGTGTC TTTTTCATGT ATCTTACAAG AAGACAGCAT GTGCTTCTAA CACCTGATAC ATTGTATCTA CCAGCACTTG GTAAACAGAA AAGAACCACA TTTTTCTTGT AGGAGAAATT TGGTGCCTAT TTCCTACCAG GCACCAATAA GTGGGACCAA TAGGTGGGAT TAAAGATACA GTAGAAAGTA TTTAAAACTT GCCAGGGGGC AATAGTCTGA AAATAAGTAA ATTGGTGCTA TAGAATGGAA GTTACAGGCT TCTTTCTTTT TTCCCACAAG ATCTGCTCCT TGAGCCCCTA GAGACTTTTC TGTCTGTTAC TGTTTCTTCA TTCCTCATCT GCAGAGCCAG CCCTGAGAAG TGCAGACCAA AGCCAGGGAA GGCTCTGCAA AGATGTACAA ATGGAAGTCA CCTTAATAAC CTCTGACTGC TGCGCATAAT ACATTTCACT CAAAAGAGGG GTTAAACAAT GGAACAGAAT ACAGAGGCCA GAAATAATGC TGAACACTGA CAACCATCTG ATCTTTGACA AAATCCACAA AAACAAGCAA TGGAGAAAGG ACTCCCTATT CCATAATGGT GCTGGGATAA CTGTCTAGCT ATATACAGAA GATTGAACCT GGGCCCCTTC CTTACATCAT ATACAAAAAA TAACTCAAGA TGGAGTAAAG ACTTAAATCT AAAACCAAAC ACTATAAAAA CCCTGGAAGA TAGCCTGGGA AATACCATTC TGGACATAGG ACCTGGCAAA GACTTCATGA CAAGACACCA AAAGCAATAG CAACAAAAAC CAAATTGACT AATGAAACTA ATGAAACTCT TTAGTTGTAC AACAGATAGT TTATCTGTAC AACAAAATAA ACTATCAACA GAGTAAACAA CCTACAGAAT GGAAAAATTT TTTGCAAACT ATGCATCTGA CAAAGGTCTA ATATCCAGAA TCTATAAGGA ATTTAAACAA ATTTACAAGC AAAAAAATGA CCTCATTAAA AAGTGGGCAA AGGACATGAA CAGATGCTTT TCAAAATAAG ACATTCACAC ATCCAACAAC CATATGAAAA GATGTTTAAC ATCACTAATC ATTAGAGGAA TACAAATCAA AAGCATAATA AGATACCATC TAATACCAGT AGGAATGACT ACTATTAAAA AGTCAGACAA TAACAGATGC TGGTGAAGGT TGTGGAGAAA AGGGAATGTT TATGCACTGC TAGTGGGAAT GTAAACTAGT

TCAGCCATTG TGGAAGAGAG TGTGGTGATT CCTCAAAGAA TGTAAAACCG AACTGCCTTT CAATCCAGCA ATCCCATTAT TGGATATACA CCAAAAGGAA TAGAAATTGT TTTACCGTAA AGGCGCATGC ATGCATATGT TCATTACAGC ACTATTTACG ATAGCAAAGA CATGGAATCG TCTAAATGCC CATCAGTGGT AGACTAGCTA AAAAAAAAAA AATGTGGTAC ATATACATCA CAGAATAGTA TGCAGCCATA AAAATGAACA AGATCATCAT GTCCTTTGCA GCAACATGGA TGTAGTTGGA GGCCATTATC CTAAGCAAAT TAATGCAGGA ACAGAAAGCC AAATACCACA TGTTCTCATT TATAAGTGAC AGCTAAATAT TGAGTACACA TGGACACAAA GAAGGGAACA ATAGACATGG GACCTACTTG AGAATAGAGG GTGGGAGGAG GGTGAGGATC AAAAAGTACC CATAGGACAC TGTGCTTATT ACCTGGGTGA TGAAATAATT TGCACACCAA ACCCCTGTGA CACACAATTT ACCTATATAG AAAACCTGTG CATGTACCCC TGAACCTAAA AGTTAATGGT GGGGGGGTGG GGTTAAGCTA CTTTGTGGTA TAAATCTGAG CATTCATATT AAAATAAAAT ATTTACCTCA TTAGAGTAAT TAACATTTAT TAAGCAAAGA GCCAAGTACC EPI-109 150

TTACACACAT GATGTTTAAT CTCACAATGA TCTTTAATCT CATAACAACC GTCCATTGTA TGTACATATG TGGAAATTGA GCCTTGGAGA GATTAAATGC ATGGGGCATG CCATTTGACT AGAAACTGGA AGCATCAGGA TTTAAACTCA GTTCTGAATG GTTTTGTAGG CTTTGTTTTT TCCACATTAT AGCATGGCCT GCCATGAAGA ACAGGTCCTT TCTGGTGTTT GTCTTGTTTG GTTTAAGTGA AGCAAATATT TATTTAAATA TTCAAGATAT GCTGTTAAAT TTTTACTCAA AAATTTGAGT ACAGTATGGA TCTTCTGAAG CCAAATAACT CTTATTCAAT GCTTAGTTGA GAAATTTTAT GGAGTAGTTC TCAATTTTTA TGTAGTTCCA CTGCAAAGGT AAGTCTTATG GAAAGATTCA CTGTAATTTT TTTTCCTCAT TTGGACATCA GCTTTTTCTT TTCCTCAGAC CCGCTGAAAG ATAATTTTTA AAATAAAAAC CTTGTTTTTA TATCAAGTGG GGACATTTTT TCCAAATGAA AACCGTGTAT TCATTTTATA TGATAAAATC AATGTTATTA TTTTTAAAAT TTTGATTTAA AAATCATTAA AAATAAATTT TCAGATATTA CCTGAAATTC TACCATCCAG AGATAATAGT GCTTAAAGAT TTGATATATA GACACACACA CATATATACA TATATATCAT CCTAAACTTC TTTGTATAAA TGTATATAAA GTTTTTAATA AAAACTAGGA GATTAATGCC CTTTGAATGA AAATAAATAC AATGTGTATG CTTTAACATC TTGCCTTTAC TTTATAACAT TTATCACAGC AGTCATGAGA TAATGATTTA CATGGTCATT GTTAGTAAGC TAATAGCTAA GTGCATGAAC TCTGGAGCTA GCCTCCCTGG ATTTTAATCC CAGATCTGTC ACTGACCAGC TGAGCAATAC TAGGTAAATT GCTCTTGTTC CTTAGTTTCT TCATCTGTAA AATAGAGATA AAAATAATAT CCACCTCATA GGATTGGTGT GAGCATTAAA TGAGCATACG TATGTAGGCC ACTTAACAAC AATGCCTTCA CATACTGAAC ACAAATATAC GAGCTGTTGT CTTATTGGGC TCATGTTTTT CCTACCACTA AGCCGCATGC ATGCAAGGAC CATGTTGGTT TTGTTCCACA TTGCATCCCC AACCTGGTAT ACAGTGTGCA TTCAATAGTT GTTGACTATT ATTACTAGTG GCATTTAACA AATATCTGTT AAATGAGTGA AGAAATACCC ATTTACTGCA AGTGTGTCTA ATATTGATGG CATAATGGGG GAAACTCAAA CTCTGGAGTC AAACAGGTTT TAAAACCTTA TTCCCTCATC CTCAGTTATT GACGTTTTTT TTTTGGCAGG TGTGTGTGTG GGACAACTTA TTGAACTTTT CTGAATTTCC AGCTTCGCAT ATATAAAATA GAGATAGTGA TTCATTCTTG CAATGTATGG ATTTGAGACA ATTGTGTAAG TTTATCAATA AATAGTAGCT ATTTTTGTAT AAGTATTACA TATAATATCC AGGCCACTGC TTTGCATAAC CCAAAAGGGG CACCATTCAT GCAGAATACA ACATAAATGG TGTCCCTGGA GCAGTGCAGT ATAGGAACCC TGAGGGGACC TACAGTATAC TTTATAGTTC ATAGATTACA AATTATCCCT TTATCAGAGT CTCTCAAGGT TGGATGTATT TGAGGTCCAT AAGAGCAATT TAGGATTAAC AGTAGCTGCA GAAACCATCT GCAGTGATAT TCTCATTTTA AATCCGCGGG AAAGAAGACA GCTATAAACT TGGGACCTGG GTTTAAGCAT TTTAAATGCC AAGTTCACCA TTTTCTAAAA CACAACAAAT ACCCAGTGAG AGAGGGAGAA GGGAAGTAAA TGCCTCTGAA TAAGCAAGTT AATGTCAGTA GTTGTACTGT ATGCATATTG ATGAACAATA GAGGAACCAA TGTCCAATCA GATGAGCAGG ATATTTGGCA ATAACAAGTT GCCTTTGAGG AAAAATGATT TTCTTGGCAA GTTCTTTATC AGCATTACAA AGCTAAAAGC TACGCTTATC ATCACTTATA CTAGCATACC CTGTTGTGCA AATGCTGTCT GTGTTTGCAT CTGCTATTGT TGATGCCTGG TGCATGAATC AGGACTCCAG CCCACAAGTT TTCCCAGAAC TTTCTTATGG CCATCATCTT TAAGTGTCTG GTGAACAGTC ATAGTTTGGT ACACAAAAGG GTCAACCTGG GGGATGGCTA GGGTTTGACT CAGTCGTTAC ATTTCAATAG AGCAGGAAGG GGAAATGGTG GCCTGTAACC TCAGGGAATT TTGCCAGTTG GTCCACCCCA CTCTCTCTCT CCTGCTCTGA GGAAGTGGCA CAGCCTAGAA CAGCACCACA GGTGAGAGAA ATGCAAACCC TAACCAGAGA AGCAGACTCT TTGCCAGTAG TAATAGTTCA GGACCACCAC CAGCTTTTAT TAAAATTTTT AATAACACTC AAGTATTGGC AGAAAGAAAT AATCTTGGGT TAACTATAAC TAGAATATTG ACTCTTCCTC TGTGGAAGAA TCAGCCAATC ACATTTGTTT ACATCAGTTC CCCTGAAGAA GAAAAATACA CTGATGTTGC AGCAAGACAA ATTTAAGCTA GATGTAAATA ACTTCCTTTA GCCTGTAATG CTAGGCTAAT TACATATTGG AACTATTTTT TCAGGGAAGA ATTGTGTAGG GTTTCAGGGA AGAATTCTGA AGAAAATATA GAGCTGAAAT GATCTTGCAG CTCACTGAAA CTGCAGGGTT TAGATCCACA CTGATACTCG TTCTATTATC ACTGTAATGA AGGCTGATGG AATAAGTAAA AATGTTTTGT ATTAGTATGT TTTTACACTT ATTTGCAAGG CATAAATAGG TTAGGTTTTG ATCTTAATTT AATTCTAACA TGTATTGTGC ACAAGCTGTG AGCAGTTTTC AGGAGTTAGG TATCTGGCCA TGACTGATTT TTCAGGAGTT AATCATCTGG TAGAAGGGTC ATACACAATA GGAAGATGTG TGTGACAGGT TGTGATCATT ACTATAATCA CACAGAGAGC TGTAGAATTT TAGGCTGGCA GGGTGGCTCA CGCCTGTAAT CCCAGCACTT TGGGAGGCCA AGGCAGGCGG ATCAAGAGGT CAGGAGATGG AGACCATCCT GGCTAACACG GTGAAACCCC GTCTGTACTA AAAATACAAA AAAAAAAAAA AGCCAGGCGT GGTGGTGGGC GCCTGTAGTC CCAGCTACTT GGGAGGCTGA GGCAGGAGAA TGGCGTGAAC CCGGGAGGTG GAGCTTGCAG TGAGCCGAGA TCGCATCACT GCAATCCAAC CTGGGCGACA GAGGGAGACT CAGTCTCAAA AAAAAAAAAA AAAAAAAGTC ATGTTAGATC CAGAGGGGTA GCAACTGGGG CTGGGCTGTC AGTCAACTCA GTCAACTCAG TCAACTCTGC TCCCCCACAG GAGATGCCAG TGATGCATTT TCATGGCCAA CATTGTCAGT CAGCATCATT GAATTACTCC TGATTATAGA GACACAGCTG CAAACGATTC CCCATTAAAT ATGATGTTTC TTGCAATGTT TGGAAGGTAC TCCTTTTTAG TAAGGGAAAT CCCCTCTTCT GGCTTGCTGA AAGTTTTTTC TTTCCATTTT AAAAATCGTG AATTCCTTTT TGCAATATTG AGGTGGTTAT ATGGTTTCTC TTCTCTAATC TGTTAATATG GTGATTTAAT GGTTAGAAAT TTTCTAATGT AAATTCCACT CATATTGCAG AAATAAACCT AAACTGAGCA TGAGGCTATA TTTrTTATTT GCTTCTATAT TTGGTTGCTA TACAGTATTA TGTTTAAGAT TTGTTCACAT ATATTTGTGA ATGGGATTGG ACTATTTTTC CTTCTTGCCG ATTTTTATCT GGTTTTTAAA TTAAGGATAT TTTAGACTTA TGAAATATTT GGCAAACAAT CCTTGGCAAG TAATTTTTTG GGGAATTTGT TTTGGCTATT TTGAGTATTA CCCAATATAT TTTAATTAAG TTATTCTTAA TGTTTTCTTA ATTAAAAAAA TTACCTACTC TAGAGATATT CTTTATGTAC TCCAGATTTT GTCTATTTAT ACCACTTTTC TTTTTTCCTC GATGAGTGTC ATAGATGTTC ATCTATTTTT TTATCTTCTT TGATCTTCTC TTATTCCTTG TTTCTATTAA CTTCTGAAGT TTATTATTTT CTTTTTTCCA CTTCCTTATG GTTTATTCTT TCAATTTTTC TCTAACTTCT TAAGTTGGGT GTTTAATTTT TAGCTTGCTT TGCTTTTTTA GGATAAGCAT TAAAACTACA AATTTTCCTT GTTATTCTTT TGCTGCACCC CAAATTGTTG ATATTTCTAT TGTCTAATTT CTATTCAATT AGAATACTTT AAAGTTTCTT TTTGGTTTTT AAAAACTAAC TTTTTAAATT GACAAATAAA AATTGTGTAT ATTTATTGTG CACAGCATAT GGCTTTGAAA TATATGTACA TTGTGGAATG GCTAAATTTA GCTTATTAAT GTATGCATTA TCTCACATAC TTATCATTTT TTGTGGTGAG AGCTATGTGA CTTTTGAACT TATGAGTTAT TTAAATATTT TTAAATTATT AAGCATATTG GGATTTTAAG TAATTTACCT TTTTATTATT AACTTATAAC AAGTAGAACA GTTAACCTGT ATGATTCTAC ATCATTGAAA TTTATTGACA TTTGCTTCAT AGTCTATTAT ATGGTCTACT TTTGTTCATG TTACATCTGT AGTAGAATTG GCTAATAGTT GAGTAAAGTA CACATATGTC TATGAAATCA AGTGTAATCC AGAGAAAAAG AGAAATTTAC TGAATATATT GTTCTAGGTG CTATTATATG TTGTCATGTT TAATCCTCAC CACAATTGTA TGAGGCAGCC ATAATTAATT CCACTTTACA CATGAGGAGC CTGAGGGTTA AAAAAAAAGC TAGCTCTACT ATTTGTAAAG AATGAAGCAA AGATACAAAT GAAGGCCCAC ATATCCTATA ACTAGATATT TAAGCATTTT AATTCAAGCT TTAAAACTGC TAAATAAAAT GTGCTCCAAT TTCTATATTG ACAGACATAC CTTCCTAATG AGCTGGGGTT CGAATTTAGA AATCTTTGAT GCTTCAGAGT CCACACTGAA ATGTGGAGGC ACATAGTGAG TTGGTCCCCA GCCTTCAGTC CACCCACCTT CTCTTTACTA AATCACCTTT CACATACATG TATGAACACC CCAGCCTCCA AGTCCAAACC CTAAACAAAA TGGGACACCC TTGTGCATAC ACAGAGACAC AGCCCATCCT CAGGAAAACC TGGAAAAGTC CATACAAGTT CTGGAAGCAA GCTTGGGACG GTTTCAGTAG TGTGGTCTAT AAGGGAGGCC TCAGAAGACA GGTTTTCTTA ATTCTGTGAA CTTCTCCCAC AGTAGAAAGG GTGCTGGAGG AGGGTCAGAG TGAGGACTTC TAAAGCATGG GTCCTGAGTA GGGGCCACTC TTGCCCAAGT CTAAGAAGGG TACTAGAATA GCACACTACT ACTAGATACT AGAACCCAGA TACAAGCACA GGTCTTCTGA AATTAATAAT AATAATAACT ATTACCATTA TTATACCAGT AGCTGTCATT TATTTAGTGC TTATTATTTG CCAGTCACTG TTCTAAATTC TTTACATGTA TTATACAACT GCCATATAAC TGCCATATGA GGGATGTACC CTCATTGTCA CCATTTTACC GATGAGAAAA CTGGCATAAA ACGTTTAAGT AACTTGTCCA AGTTACAGAG CTTAGTGAAG CCACAATGTT GCTCAATTTG CTCTCAAACT TCAAAGGGAT GGGAAGGACA CCTAAGTCAT AGAGTCTTTA AGAATCAGAG CTAGAAGGAA TCTTAGATGT TATCTAGTCA GCCTCCTCCC ATTACAGTCC AAGAGAAGAT GGCCCTGAGT TACTTGTAGC TATTTTTGCA EPI-109 151

TGTGAATTGC AAGTGAATAT ACATTCTACT GAAGATAAAA GATATTTAAA GATATCGCTG GATATAGGAA CAGTGGTTTT AAATCTCTAG GCTTTAACTT TTCTCAGAAC AAGAAATCCT TTTTGGTTTT AATCTATATG CACATCTGTA TTTTTCTCAA TTATCGGGTA GTAAAATATA ACTTTTCTTC TGTAATATTT TTTAACTTTA ATGAGTGTTC CTCATAATAG AAAAGTTTGG AAACCATTGC TATGGGTATA TACTTTCTAA AGGGATAGTA ATTTCTCTAG AATATTCATT TAATGCTCCA GAAGTAATTA GCACAATTGT GCAAGTCTGT GCATCATCAA CTATACATTC TGCCTGTTTA CTCCAAATCC ACATGAAACT GATTATACAG TCAAAGGCGA GCCCAGTGGA GAGGCATTTT TGGAGACTTC CTGGTACATT GAGACAGGGT CGGCCAGTCT GCGTTAGGGT CTTGGTCAAA ACTGCATTTC TGAAACTAAA CTCAGATTGC TTTCTTTTAA GGGGTCAGAA CTGATTCAAA TCTACATTTT TAAAAGCCTT AGATGTGGGG CTTTTCCTAT TCCCAGTCTC CGCTATTGGT CTTTGTGAAT CCACAGGCAA TTTGGCCACA TCCTTGACTC TCTCTTATAT TAAGAATTAA ACAGCTAAGT TCATGCAGAG GAAATATAAC AAAGGAGGGA CTTTCCTACA AGATCTTTGA AAAATGGAAC ATTTGCATAA GTCATATTTA GCCAGAACTG TTGTTTTATA TTTTCCTTTC TGAATACTTT GTTACACCTC CTCCCAGCCA ACCCCCCCCC TCCCTGACCC CAACTAGTCA GAGACCAAAG CCTTCACAAT GGTTTACACT TGAACCTTCC TGGCCCCACC CTCATCATCA CGCCTGAATA ATTACATTCA CTGACTGGTC TCCCCTGCTT CCGTTTATCT CCACTCCTAA ACCCTCTGAC ACCTTAATCT TCCCAGAATA CCATTGTGAT CCTGTTCCAC TCTTGCTCAA GTTTTCCCAG AAACTAGAGT ACAAACTTTA TAAGCTTTAG AGTTGAAAGC CACTCTATCT CTTTTTCATC CCCAGGTCTC TGCCAAGGCA GTATAACCTG TCCAACATCT CTAACTTCAA TACCTTTGTC TTAGATACTA GACTCTCCTC CTGGTTTCTA ATTAAACCTG ATCTAGGATC TAATTTTGCC TCTGAATTCT GTTGCCCTTT GCCAAGTGAT CTCTTCCTCC TCTGAGCCGC AGCATCTCTG AGCTTGCACA CTTAGCATAG CCATAGCACA CACAGCCTTA GCTTGCAGTT CAGGGTGTTT ACCTTCCCTC CCCTTCCAGA TGCTGGATCC CCAGGGATAG GAACTCTGCC CTTATGTGTC CATAGCCCCT GGTAGTATGT CTTGCAGTCG TACATTTTCA GCAAATGTTT AATTGGTTAA TTGAAGACAA CTGTCCCATG CCTTAAGCCT CTCTTTTTGC TAAACATGCC TGTGTCCTTT GTCATTGAAC AACTATTTTG ATCTATTTTC TTCCTGACAT AGGGGTCAGT TCCGAGGATG CTGAAATCAA GAGACATAGC TTATTCTCTC AAAATTGCTT TCAAGAGTGA TTTTGTTGTG AATTGAGAAC TGGCTGCCTA CTTTTGGACT ACCCACTTCA GCAAGAGTGT TTGAAACCAA ATCTATTCTA AGTAATTTTT TATTCCCTTT TCTCTATGGC ATTAGACACA CAGCTCTTTT AAACTACCTT TCGTTATCTA TTAAACAGAC ATTCAGTAAC TCTATAGACA CTGTCTAGCT ATATGAACTT AGACAAACTA ATATCTCTGA GCTTCAGTTT CTTAAAATTT AAAATGAGGA CAATACCATC TATGGCCGGG GATTAAATGC TATGAGGAAT GTAAACCAGA TGTCAGGTAC CATCTCTCTA AAATCCAGAT AAAATGAATT AAAAATACTG GCCGCAAACC CTCTCTAAGA GTTCTCAAAA TTCTCAGAGA GCTTAATTTT CATGCTCACC ATAGCACCGA TTTTCTTCTA AATATTTTGT TTCTACCAAA ATATTTTGTC CCAATTTTGC CTTTTATGGC TATTTCTTCA TATCCACTTT CCCAAACTAA AGAAGCAGCC CCTTCACCTT AAACTCCTCC TTCAAAGCAA CCTAAATACA GGTCTGGGTT TGTATTCCTA GTGGGATGTT ACAGAGGTTA GTGTGATGCA GAGGAGGAGT CATGCTGTTT AAATCCATAC TAGTCCCCAG AGGCCAGGCT GCTTCTGCCA CCCCTACCCC TCCCGCCACA GAGCTCTTCA GCTTCTCACA TTTCTAGTTC TTCTCTCTCT ACTTTCATTA CCTTCTCTCT TTTTTTTTTT CTTCTCATGT GCTCACGGGA GCAGAGAAAA TTAACTCCTC TAAGTTTTCT TAACACAGAG TGCCTTAATT ACATATTACT ATTGTTTGAG TTCCTGCCAA CACTACGTCT GTAGGGTCAC ACCTGCTATA TTAGAGGCTT ATCAAAAAAA GATAGCTTTC TCCTAAAAAG GGATTTGGAT GCCTACTAAG ATAACTGGAT GCCAAGATAA GTTTAACCTA ACAAACTTTA TTATTATTAT TATTATTATT ATTAGAGATA GGTACTTATT CTGTCACCCA GACTGCAGTG CAGGGATGCA ATAATAGCTC ACTGCAGCCT CAAAGTCCTG AGTTCATGCA ATCCTTCTGC TTCAGCTCCC TGAGTAGCTA GGACTACAGG CATATGCTAC TCTGCCCAGC TACTTTTAAA AAAATAATTA GGGATGGGGT CTTGTTGTAT TGCCCAGGCT CGTCTCAAAC TTCTGGTTTC AAGCAATCCT CCTGCCTTTT ACCTCCCTAA TTGTTGGAGT TACAGGCATG AGCCACAGCA CTCAACCAAG ATTTAAAAAC TTTTAAAAGA AATCACATTA CTTACTGTTA TCATCATTAT GGTTACTACC AGTGTTAAAA CAATTGGTAT TGAAAACACC ACTACCAGAT CAAGCTTCAA ACCAAGATGT CAAGTAAATA TTATTGTCAG ACCTCTGAGC CCAAGCCTGC AGGTATACAC CCAGATGGCC TGAAGCAAGT GAAGAATCAC AAAAGAACTG AAAATGGCCG GTTCCTGCCT TAACTGATGA CATTCCACCA TTGTGATTTG TTCCTGCCCC ACCTTGACTG AGGGATTAAC CTTGTGAAAT TCCTTCCCCT GGCTCAGAAG CTCCCCGACT GAGTACCTTG TGACCCCCAC CCCTGCCCAC AAGTGAAAAA CCCCCTTTGA CTGTAATTTT CCACTACCCA CCCAAATCCT ATAAAACAGC CTCACCCCTA TCTCCCTTCG CTGACTCTCT TTTCAGACTC AACCTGCCTG CACCTAGGTG ATTCAAAAGC TTTATTGCTC ACACAAAGCC TGTTTGGTGG TCTCTTCACA CAGACCATGT GACATTTGGT GCCGTAACTC AGATCGGGGA ACCTCCCTTG GGAGATCAGT CCCCTGTCAT CCTGCTCTTT GCTCCATGAG AAAGATCCAC CTATGACCTC TGGTCCTCAG ACCAACCAGC CCAAGGAACA TCTCACCAAT TTTAAATTGG GTAAGTGGCC TCTTTTTACT CTCTTCTCCA GCCTCTCTCA CTATCCCTCA ACATCTTTCT CCTTTCAATC TTGGCACCAC GCTTCAATCT CTCCCTTCCC TTAATTTCAG TTCCTTTCTT TTTCTGGTAG AGACAGAGGA AACGTGTTCT ATCTGTGAAC CCAAAACTCC AGCACTGGTC ATGGACTTGG AAAGACAGTC TTCCCTTGAT GTTTAATCAC TGCAGGGATG CCTGCCTGAT TATTCACCCA CATTTCAGAG CTGTCTGATC ACTGCAGGGA CGCCTGCCTG GATCCTTCAC CTTAGTGGCA AGTACCACTT TGCCTGGGTG GCAAGCACCA CCTCTCCTGG GGGGCAAGCA CCACCTCTCC TGGGGGGCAA GTACCCCCCA ACCCCTTCTC TCCATGTCTC CACCCTCTCT TCTCTGGGCT TGCCTCCTTC ACTATGGGCC ACCTTCCACC CTCCATTCCT CCCTTTTCTC CCTTAGCCTG TGTTCTCAAG AACTTAAAAC CTCTTCAACT CACGTCTGAC CTAAAACCTA AATGCCTTAC TTTCTTCTGC AATACCGCTT GACCCCAATA CAAACTCAAC AATGGTTCCA AATAGCCTGA AAACGGCACT TTCAATTTCT CCATCCCACA AGATCTAAAT AATTCTTGTC GTAAAATGGA CAAATGGTCT GAGGTGCCTG ACATCTGGGC ATTCTTTTAC ACGTCGGTCC CTCCCTAGTC TCTGTTCCCA ATGCAACTCA TCCCAAATCC TCCTTCTTTC CCTCCTGCCT GTCCCCTCAG TCCCAACCCC AAGTGTCGCT GAGTCTTTCC AATCTTCCTT TTCTACTGAC CCATCTGACC TCTCCCCTCT TCCCCAGACT GCTCCTCCTC AGGTCGCTCC CCGCCAGGCT GAATCAGGCT CCAATTCTTC CTCAGCGTCC GCTCCTCCAC CCTATAATCC TTCTATCACC TCCCCTCCTC ACACCTGGTC CAGCTTACAG TTTCATTCTG TGACTAGCCC TCCCCCACCT GCCCAACAAT TTCCTCTTAA AGAGGTGGCT GGAGCTAAAG GCATAGTCAA GGTTAATGCT CCTTTTTCTT TATCCAACCT CTCCCATCTC AGTTAGTATT TAGGCTTTTT TTCATCAAAT ATGAATACCT AGCCCACTCC ATGGCTCATT TGGCAGCAAC TCCTAGACAT TTTACAGCCT TGGACCCAGA GGGGCCAGAA GGTCATCTTA TTCTCAATAT GCATTTTATT ACCCAATCCA CTCCCAACAT TAGAAAAAGC TCCAAAAGTT AGACTCCGGC CCTCAAACCC CACAACAGGA CTTAATTAAC CTTGCCTTCA AAGCGTACAA TAATAGAGTA GAGGCAGCCA AGTAGCAACA TATTTCTGAG TTGCAATTCC TTGCCTCCAC TGTGAGAGAA ACCCCAGCCA CATCTCCAGT ACACAAGAAC TTCAAAATGC CTAAGCCACA GTGGTCAAGC ATTCCTACAG GACCTCCTCC ATCAGGATCT TGCTTCAAGT GCCAGAAATC TGGCCACTGG GCCAAGGAAT GCCCTCAGCC TGGGATTCCT CCTAAGCCAT GTTCCATCTG TGTGGGACCC CACTGGAAAT CGGACTGTCC AACTTGCCCA GCACCCACTC CCAGAGCCCC TGGAACTCTG GCCCAAGGCT CTCTGACTGA CTCCTTCCCA GATCTTCTTG GCTTAGTGGC TGAAGACTGA TGCTGCCTGA TCGCCTCAGA AGCCTCCTGG ACCATCACAG ATGCTTTTGG TAACTCTTAC AGTGGAGGGT AAGTCCGTCC CCTTCTTAAT CAATGCAGAG GCTACCCACT CCACATTACC TTCTCTTCAA GGTCCTGTTT CCCTTGTCTT CATAAATGTT GTGGGTATTG ATGGCCAGGC TTCTAAACCC CTTAAAACTC CCCAACTCTG GTGCCGATTT AAACAACATT CTTTTATACA CTTCTTTTTA GTTATCCCCA CCTGCCCAGT TCCCTTATTA GGCTGAGACA TTTTAACCAA ATTATTTGCT TCCCTGACTA TTCCTGGACT ACAGCCACAT CTCATTGCTG CCCTTCΓTCC CAACCCAAAA GTGGCAACTC CTTTGCCACT TCCTCTCATA TCCCCCTACC TTAACCCACA GGTATGGGAC ACCTCTACTC CCTCCCTGGC AACAAATCAC ACCCTCATTA CTATCCCATT AAAACCTAAT CACCCTTACC TGGGTCAACG CCAGTATCCC ATCCCACAAC AGGCTTTAAA GGGATTAAAG CCTGTTATCA CTTGCCTGTT ACAACATGTC CTTTTAAAGC CTGTAAACTC TCCTTACAAT TCCCCCATTT TACCTGTCCA AAAACTGGAC ATGCCTTACA GGTTAGTTCA GGATCTGTGC CTTATCAACC AAATTGTCTT GCCTATCCAC GCCATGGTGC CAAACCCATA TACTCTCCTA TCCTCAATAC EPI-109 152

CTCCCTCCAA AACCCCTCCA TAACCCTTAT TCTGTTCTGG ATCTCAAAAC ATGCTTTCTT TACTATTCAT TTGCACCCTT CATCCCAGCC TCTCTTCACT TTCACTTGGA CTGACCCTGA CACCCATCAG CCTCAGCAAC TTACCTGGGC TGTACTGCCG CAAGGCTTCA TGGACAGCCC CCATTACCTC AGTCAACCCA AATTTCTTCT TCATCCATTA CCTATCCAGG CATAGTTCTT CATGAAAACA CACGTGCTCT CCCTGCTGAT CATGTCCAGC TAATCTCCCC AACCCCAGGA CTGGCAAATT GACTTTACTC ACATGCCCCA AATCAGGACA CTAAAGTACC TCTTGGTCTG GGTAGACACT TTCACTGGAT AGGTAGATGC CTTTCCCACA GGGCCTAAGA AGGCCACCGT GGTCATTTCT TCCCTTCTGT CAGACATAAT TCCTTGGTTT GGCCTTCCCA CCTCTATACA GTCTGATAAT GGACAAGCCT TTACTAGTCA AAGCACGCAA GCAGTTTCTC AGGCTCTTGG TATTCAGTGA AACCTTCATA CCCCTTACCG TCCTCAATCC TTAGGAAAGG TAGAACTGAT TAATGGTCTT TTAAAAACAC ACCTCACCAA GCTCAGCCTC CAACTTAAAA AGGACTGGAC AGTACTTTTA CCACTTGCCA TTCTCAGAAT TCGGGCCTGT CCTCGAAATG CTACAAGGTA CAGCCCATTT AAGATTCTGT ATGGACGCTC CTTTTTATTA GGCCCCAGTC TCATTCCAGA CACCAGCCCA ACTTGAACTG TGCCCCAAAA ACTTGTCATC CCTACAATCT TCTGTCTAGT CATACTCCTA TTCACCATTC TCAACTACTT GTAAATGCCC TGCCCTTTTT TACAGTGCTG ATTTATACTT TTCCTCCAAA CCATCATAAC TGATATCTCC TGGTTTTACC TCAAACCGCC ACCCTTAAGT CTCTCTTAAA GTGGATAGAA GATCTTCAGT GACAAGGTAC ACTCCAATAC TTTCACCCTA ATAAAGCCCT ATTCTTTACT TTTATATTCA CTCTTATTCT TGTTCCCATT CTTATGCCAC TCTCTACCTC TCCCCAGCTA TCTCCACCAC ACTATCAATC TCACTCACTC TCTCCTAGCC ATTTCTAATC CTTCTTTAAC AAACAATTGC TGGCTTTACA ATTTCTCTTT CCTCCAAAAT CACCGAGTCC TCAATTTACT CACTGCTAAA AAAGGGGACT CTGCATATTT TTAAATGAAG AGTGTTGTTT TTACCTAAAT CAATCTGGCC TGGTATATGA CAACATAAAA AAAACTCAAG GATAGAGCCA AAAACCTTGC CAACCAAGCA AGTAATTATG CTGAACCCCC TTGGGCACTC TAATTAGATG TCCTGGGTTC TCCCGATTCT TAATCCTTTA ATACCTGTTT TTCTCCTTCT CTTATGCAGA CCTTGTGTCT TCCATTTAGT TTCTCAATTC ATACAAAACC GTATCCAGGC CATCACCAAT CATTCTATAC GACAAATGTT TTAAGGGAGG AGACCACCCC TCATATTGTC TTATGCCCAA TTTCTGCCTC CAAAGAAAGA AGTAAAAATG AAAAGGCAGA AATGAAATCC ACAGGCAGAC AGCCTGATGC CACACCCTGG GCCTGGTGGT TAAGATCAAC CCCTGACCTA ATCAGTTATG TTATCTATAG ATTACAGACA TTGTATGGAA AAGCACTGTG AAAATCCCTG TCTTGTTCTG TTCCTCTAAT TACCAGTACA CGCAGCCCCT AGTCATGTAC CCCCTGCTTG CTCCCCCTGC TTGCTCAATC AGTCATGACC CTCTCACGCA GACCCCCTTA GAGTTGTAAG CCCTTAAGAG GAAAAGGAAT TGTTCACTCG GAGAGCTCGG TTTTTGAGAC ATGAGTCTTG CCAATGCTCC CAGCTGAATA AAGCCCTTCC TTCTTTAACT CAGTGTCTGA GGGGTTTTGT CTGTGTCTTG TCCTGCTACA GTTTCATCTA ACAACCCCAT AATATCACCC CTTACCACAA AATCTTCCTT CAGCTTAATC TCTCCCACTC TAGGTTCTCA CGCCACCCCT AATCCTGCTC GAAGCAGCCC TGAGAAACAT CGCCCGTTAT CTCTCCACAC CACCCCCAAA AATTTTCACT GCCCCAACAC TTTACCACTA TTTCGTTTTA TTTTTCTTAT TAATATAAGA AGATAGAAAT GTCAGGCCTC TGAGCCCAAG CCTGCACGTA TACATCCACA TGGCCTGAAG CAAGTGAAGA ATCACAAAAG AAGTGAAAAT GGCTGGTTCC TGCCTTAACT GATGATATTC CACCATTGTG ATTTGTTCCT GCGCCACCTT GACTGAGGGA TTAACCTTGT GAAATTCCTT CCCCTGGCTC AGAAGCTCCC CCACTGAGCA CCTTGTGACC CCCACCCCTA CCCACAAGTG AAAAACCCCC TTTGACTGTA ATTTTCCACT ACCCACCCAA ATCCTATAAA ACAGCCCCAC CCCATCTCCC TTTGCTGACT CTATTTTTGG ACTCAGCCCA CCTGCACCCA GGTGATTCAA AAGCTTCATT GCTCACACAA AGCCTGTTTG GTGGTCTCTT CACACCGACA CGCGTGATAA TTATTATATT ACTTTTAACT AAAACCCTTT CAGAGTCTCG CAGGGAAGGC TGTATATATC TCATAAAATG TTGGGGCCCA CTGGATCAGA CAAGGCCACA AAGGCCAAAG GGAAGTAAAG ATCTCATTAT TTCTCCTAAT AATTTCCCTG TCCTTTGTCA TAAATGGTGG GTAGGCTGTT ATGGTGATGG CAGATTTTCT TTCCATAAAA TGTCCATAAT AGGACATTTG AACAGAAGGG AAAAATCAAA TTGCTGAAGT TGAAAGAGGG CAATGCAAAG AACTTTGGAG AAAGAACTGT ACAGAGAAGT CAACTGGCAG ATGGGAGGAA GTTTAAGGGG AAAAATATAG ATGTCTAAAG AATACATTTA TTCATTTTCC ACAGTGCAAT TTGGACAAGA AGCCTCTTTC TTGCTTCTTT CTATTCTCAT TAAATCATTA GAGCTCAAGC AATCCTTCTG CCTCAGCTTC CCGACTAGCT AGGACTACAG GTATGTGCTA CTATGCCCAG CTAATTTTTT AAAAATTAGA TTTTAATTTG GTGAACTATT TCTGTAGGAA ACTACAATAA TACAGCCCAG GCACATTGAT CTTGGGTGAA CAAATCAGAA GGAATGAATA ATTCTGTGTT CCTGGGACTC TGACAATTTC ATGAACTTGG TACTCTGAGT AAAGCATAGG AGGAGTTATT TCATAAAATG TGGAGCACAA TCATGTGACA AAGATAATGG GATCCCCATT TCATAAATAA ATCTGAAGTT CAGAGAGAGT AACAACTGGC CAGGGTCACA TCACGGAGAC AGAGGCAGGG TTCCCACTGA TGCCTCTGAC TCCCTGTCCC AGGCCCTTCC TCCTCCCGCA AGCAGAAGTG CAGGGGGCAG AGCTGACCCT GTGCAGTGAA AATCTGAGGG CTGAGTTCCT ATTGGAACAC AAGTGAAAGA CTTCCTGGCT TCTAATCTCA GGATAAGGAC TCAGAGCTCC ATCTGTTCCA GCCTTAGGAT AAGAACCAGA ATCTTACACC ATGAAAGCAT GAAAGGTAAG ATTTGAGTGA GGAAAAAAAA AAAAAAAGTC TGTGTTTCAG ATTCAGTTCA CAAAGCAGTT TCATACTTAA GGTACCATCA CAATAACCCT GTGGGGTAAG CAAGGCAAAT TTCATTCTTG TTTTATGGGC ATAGGAAGTA AGTCTCAGGG AGGTTAAGAC CAAGGTTTCT GGAGAATTTT ATATTATGAA TCTTGATTTA TGGGATTACT ATTATGTAAT TCCTAAGATC ATATAGGAAT CCTAGAGCTT GAATATAGAA CTTTATTTTT AAATCTATAT ACATCATAAT TACAAGGAGT AGTGTCCATT TGGGTTCCTT GGCCCTGATG TGTTAGTGGA ATAAACATTT TTGTCAGGGT TGCCATGTGT GTCTGTGCAC GTGTGCACTG TACACCTCCA GGGGATGTAC CCTAAACCAC ATGAATGTGA TTTGCACATC CAAGATTTAC AGTGTACTAT AGGGAGAATC TTTTGCAACA GCTTTTGCTA TAATACAGAA TCTGAGATGT CTTTGAGAAA GAAAAGTGTA ATCATTACCA AAAAATTATT CTCATAATGT GTGCAAATTT GTATGAAATC TATATTGGCC ATGGGACAAG GAGGTATTTC CAGCTAGCTT CTGAAAGGGC TCTATTCTCT CATAAGAATT CAGCTGTTGA CATTAGGTGA TATCTGCCCA GGTCATCAGA TGCCATAGAG AAAGAGGGTT TGCTGAAACT TATATCAGCA GTGCACTGTA TGCTCTTTCT GATTTATTTG AACATTCATT TATTGAGTGT CAAGTAATGC ACTAGATACT CCAGGGATCT GACACAAACT CTGCCCTGAA GGAGCATGTA ATCTCACTGG GGAGAAAACA AAACATATGA TAATTTCAAA ATAACAAACT AGGCAAACTA GTTAACACTT AAAAAGCAGG CTTTATTCAA ATGCAAAATT GCATGTTACA GGGTAACCTT TCAGTAAGAA GCCAGGAAGA GGAGCTCATC ATGGGTTGGA TTAGTAAAGG ACTAGTTATA AAAGAAGTGG TGGGGTTGAG GGAGGCCTGA GATGAAATTT AAAGAATATG TAGAATCTAG GTAAGTGGAT AAAAGGTCTG GGGGCAGGGG AAAGGAGAGC ATTTCATTGT GAATCAAGGA ATTTCTCCAC CTGTTTTAAC TCTTCCATAT GACATCAAAG AGATGTCACT TGCAGCTAGC ATTTCAGTGA TGTTTTCTTA CTAATAA AT CGTGATAAAA GAAACATTGA CTATAAGAAA TAGGAATGGG TCTCATAAAA GGAAACAGCA AAACCCCCAA ACTAAAAAAC AGCGCAGGCT ATTTCTCTCT TCTCTCCTTT TGCTTGGCAC TCATGAGATG CTAGGTGTGG AAGTCAGCCA ACTGAAAAAG AGAGGTGGCT GAAGAAGGTG GGGAGGCTGA AGCCAGTTAA ATAGGATGGT CCAATTCACA GACGGCGAGG CTACAGTGCA AATAGGACTC TTTCAACTTG AGCAGGACCC CATTACTTCA CTGGAGTTAG AAAGAAAGGA GAGCGTAGAC TTTTTGAACT TTCTATAAGA GTGTACCTCC ACAGTATACA GAAGACGACG TGAAATTTGA TCTGCAAGAA AACTGAGTCC ATATTCACAT ATGTATCAAA TTTGCACTTC ATTTAGAAGT GTCTGTCATC AAGTACAGCA CTGAATTGAA ACTGAAAACA AGAGTCAAGA AAGAGCAAAG TCAGCCATCT TTATATTCCA CATGAATCCT TTCCCTTTAT GGTCTTATTT GTTTCTCCTC AGAAAAGACA AAAAGCTGAG CTGTATAAAC ACCTGTGGGC TGGGGGTTGA GGGATAAATG AGGGGCGAAA TGGAAGCTGA AGGAACTGTT GGTCAGGTAG AAATCTTCCC AGATGCACTG AAGGAAACAC ACTTCATGTT TGACGTAGGA GGTGCCACCA CACAAAACGT TTCATGGAAG GATTTAAAGG ATCTCATGAT TTTTAGTATT CCAAGAATTT TCTTTCACCA AGGGCGATTT AATATGGGTC ATTCATACTG AAAGAAAAAC AAAAGATAAT AAGAGTTTAA AAATTGCAAA ACTTGGAGTG TTAGTAGTAA AGGTAAATAT TCATTAGAGA TGAGAAGAGG AGCAAGGAAA TGCTTTCAGC TGGAAATCTC AGACAAGAGG CCAGGCTTTA GGAACCTCTG AAGATGAACA AATGTAAGCA AACCCTAGTA GCAGCACTTC TCAGATTTTC ATGTGCTTAC CACTCAGAGA TGGTGTTAAA ATGCAGACTC TGATTCAGTA GGTCTGAGTG GAGCCTGAGA TTCTGCACCC CTAACAAGCT CTTTAGTGAT GCTTATGCCA CTGGCGCACA GACCCCACTT GGAGAAATTT TTGTGGTGCA TACGGTCTTT EPI-109 153

GTCTCCAGAT CTAATGAGTC TGAAGGACAG TGTAGATTGA TTTTTTAAAT TTATGTTTAT TTTAATTTAA TTTAATTTAA TTTATTTATT TATTTATTTT TGAGATGGAG TCTCACTCTG TTGCCCAGTC CGGAGTGCAG TGGCACGGAG GCAGCTCATG CAACCACGGC CTCCTGGGTT CAAGCGATTC TTCCGCCTCA ACTTCCTGAG TAGCTGGGAA TACAGGCACG TGCCAGCACA CCCAGCTAAT TTTTGTATTT TTAGTAGAGA TGGGGTTTCA CCACATTGGC CAAGCTAATC TCAAACTCCT GACCTCATGA TCCACCTGCC ACGGCCTCCG AAAGTGCTGG GATTACAGGC GTGAGCCACC GAGCCCAGCT GTAGATTGAT TTTGAGCAGT GGAAAGTCAA GGAATTAGAA GGCATGCTTA AATGGAAAGT GAAATTGGAG AAAATTTAAA CTCATGAAAT AGTGGTGGTT ATAAACTCGT GATAAATTAT ATCCTGGGAT ATAATTTAAT GAGATGGTAA CACATTTAGT TTAAAGAAAT AAGTGACACT TTTTTTGTGT GACACAACTG TCTTATTCTT GGAAAGGACA AGGAGAGAAT GAAATATGGT ATGTCTTCAC AGCACCTTTC AAAGGGAGAA CCAGATTCTG AGGAGCTGGT CTCATGATGA ACTGTCAGGG TAAACCACAG TTCAGCAGCT GCAAATGTGC TTGCCAAAAT AGAGACAAAA AAATGTTTCT GAAAACAAAA TTTCACATAT GCCCTCCTCT GAGGTTGGCA TCATATCTTC CTGTGTATCT TGGGTGTAGC TTCTATCCTG CCAGAATTTA GACAGTAGAA ACCAAATGAG GTGATAAACA GAGTCATTTT GCAGAAGAGT CAAAATAACC CAGCAAGAAA TGAAACCACA AATGCCCAAG GAGTCATTCA TTCACCATTC AAAAGCTAAT AGAAATGAAC ACAAACTACT ATGAAAATTC ACCCAAGAAC TTAAAAAAAA AAAAAAAGGC TCATGGTGTT TAGTGTGATA GTATTCATTT TACCTTTGAC TTGTTCTAAA AACACACCAT ACTTCTACCC CACCCTTCCT CAGTGCCGTC ACACAATGGT TTCAGTGTGA AAAAAAAAAC CACGTTACTG GAAAAGGAGG GTGCCTGGGA CTTGCCACTC TAAGCTGGTA GTCAAGGGTC TTGAGTTCTA AAAGCATACG CGTTAAGAGC ATGATTCCTG GATCCAAATG AGTATGGATC TCAGCATTGC CATTTATTGT GACCTCAGGC TATTTTATTT CTCTGTGCCT GTTTCTTTAT CAGTAATGAA GATGTTCATA GACCCTTCTC CCACAGACTT AAAGGCATAT TTCATGATTT AAGACATGTA AACCATTCAT AACAGTATAC AACATGGAAT TAATATTTGA TAAAGGTTTA TGATTATTGT AACTAACTCT GTCACTTGCT CAAGGCCTAT AGAAAACTTA CTTAATTAGT TCAACTACAA AAAGAGTTTG AATGTGATAT CCACCAAGAT CATATTCAGA CCTAGAATTC TGTGATTCTT ATGAATTAAT ACAGCCTTGG TCAATAAATG AGAGCTGGGC AAATAATTCT TCTTTGCTAG GCCTTTCTAG ACCATCTGGT GAAGCATTCA AGACTTATGT TATTGGGGCC AGCCTTCCTT TCCAACTTCA ACTCCACAAC TCCTCAATAA GCCATGGGCT CAAGAAAGTT CTGCTCAGTG GCCCCTGAAA AATGCTTTCA TAGTCTCACT ACCATACCAC TGCTTACACA ATTTCCTTCC TACAGACTGC CTTCCTTTCC TGCTTTTCTC CATATACCTA AATCCTATCT ATTCTTCATA AGCAACCTTC TTTATAACAT TTTCTATAAC CACCAAGCCA AATGACCTTT TCCTTCTTAA ATATAGCACC CATTGGCCAT TACCATGCTC TGCCTTGTAT TTTTCTGATT TTTTTCTTTC TATATTCCTG TCTTAACTCC CCAGCTAGGT AATAATTTTC CTGAAATCAG GGACCAGGCT GACTCCTCTT GCTGTCTCAA GAAAGCTTAG CAGTTTCCAA CACAAAAATG TTCAATAAAC AACTATTAAT TGACTGATTA TAAAAAATCA GTGAACCATT AAACTTAATA TAGCAATTTG CTTAGCATGG TAATTAGCTT TTTGCTAATA TTCTTCCAGC CAGTCTCTCC TCCTGTGCCT CAAGGACATC TTAAAAAAAA AAAATCTAGT TGATCTGCTT CCATCTAGTG GCAATTAAAA CAGGTGGTTC CGGTAGCCAG AAAACAGCTC TGGGTAGATT GTGCCAGAAA ATACTTTCAC TCAGTAGGTG CGAGTTTGAA AGAAATCTTC ACATCTGTGG GTTTCCTGCC ACAGACATAG GGAGACCAGC CCAGAGAAAG AAGCCTTTCC TCACTAGACT CCATTTGCAC TAGTAAAGAG AAGACAGAGT AATTAAAAAG AATAAAAAGA ACCTCCACTG ATCGTACATC CTCATCCAGT TACCCCTGCC CCACTTCTCC TTCACAGCCA AACATTTTAA AAGAGATGAC TGCTTGTTCT GTCTCTACTT TCTCATCCTC AGTAATGCTC AATGCTTGGC CGTCTGACCT CTGTCTTGAT GTCTGCACTG CAAATAGTCT CCCCACTGAC ACCCTTGTTG CATCCAGGGG ATACTTACTG GTTCTCTTGG CAATGTTTGA AACCGTTCCC CTTTCTTTGT TTCCTTGGCA TTCATTACCC CACACTCTTT CTCCTCTTCC TTCTCCCTGC CTGGCAACAT CTTTTCATTT CTCTTTCCCT TAGGTGACTT ATTAGATAAT GATGTTCCTC TGGCTCCCAT ACTCTCTCCC AGGTCCTCTT CCATTCTTAA AGCACTCACA CCCTCCCTGG ATGATAGTAC CCACTCCTGA GATGGCAGTT ACCTCCTGAA ATGTGAGGGA CCCAAATCCA CTTCTCCTGC CATAGCCTCT GTGCTTTGGA TAGGTCCAAT GAGCCACAGT GAATGATGTG CATACACCCA AAGCTCAGTA CAAAACTGAA CCCATGATCT TTACCTCCAA AACCTCTCAT TCTTTTATGT TCCCTTCTCA GAAGTAAACA GGACTACCAT CCGCCAGTTT CCAGGTGAGA AAGATGATAA TTTGATTCTT CTCTCTCACT TTTAGCCAAT TAACAGACAC ATTCAGTTAA TATCACCTCC TCTTATTTCA TGAACCCATT CTTACTACTA GTTCCCTAGA CAGGCGCCAT CGGTTTTAAT CTAATAACTG CAAATGCCTC CAAAACAAGT CTCTTTGAAT CCAGGCTCAC CTGTCTCCCA CACTTGCCAT ACTGCTCTGC AGGGTGACCT TATAAGATGC CAGAGGTAAG GCTACTCACT GTTTAAACCC CTTTAGTGAT ATCCCAAAAG ACCTCAAGAT AAAGCCCATA TCACATGGCT TATACATTAG TTTATGATCT GGCTTCTGGT GCCTCATTTT TCCCCACTTT TTCCTTTGCA TTCTAAGCAA TGGCCCATAC TAAGTTTGTG ATTGGTAGGA TGGTTGCCCA AACCAGCATC CAATCCCTTC AGAAATCATC TCACTTCATT TCTAGCATTT TAAAGGAAGC TCAGTTGTCC AGCTGGGTAC TGAATATGTC ACCAAAGTCC TCCTTTCATA GTTTATTTTA CTTAAACTCT CCTTCCTAAA ATTCCAGAGC AAGTCACTAA ACCCTAGATA CTGAGAAATA TTTTTCCATC TTCATTTCTG CCAGGTGGGC CATCAACTTT CACATGTCTG CATCTCCTCC CACTGTGCTA TTTCTCCAGT AGAAGAAATT TGAGCTTCAA GACCAAACTG AAAAATACTT GCCTCCTTGG GGAAGCTGTA GGTAGAATTC ATGCTCCCTA TCTTTCCCAC ATTTCTGAAG GACAATGCCT GTTAGAGCAA TTGAATGCAA ATAGTCAATT GAATAAGCAT TTATTCATTT CTCAATAAGT GCTTGTTCAA TTGAATATTT CTTAAATAAT ATATTTAAGA ACAAGAAGAA CACACCACAA TGTTTTTAAC CCTCAGAAAA AATTCTGAGG TAATCAGAAA AATCTCCCTT TACATAAACT GCCCTTTTCT AATAGGGATT ACTTGTTCGT TCATTCATTC ATTCAGCTCC ACTAGCACCA AAAAGCACAG CTCTGAAAGG AAGCTAGTAG ATTTATCACC TTATCTGGTC ATTTGGATGA GGACCCCAGG TAAATAAACT ACTATGGGGT TAATGTGTCT AGCTAGAGCA GGAAGTAACT TAAGGAAGTA GAGAATGAAT CAGCAGATGT GGAAACTCCT CGCCACTAAT AAAACTTACC TTCTCTTGGA TTTCTTGCCT GAAAATAGAA AATAGAGAAA AGGCATTAGC AAAAATTAGA CAATTTAAAG TTTTTCAAGT AAGGGAGAAG GAAGACTCCC ACTCTCAAAA CTGTCTTTTG AAGTATATTA GGTATTTGTT AGGTGGACCC TATCTGTGTC AAAGGAGATT TGAGGAACTG GCTTAATAAA CAGTGGTAGA CACTAATACA GAACAGACAT GTTGATGCAG ATGCCTCCTG AGGTTCCATT CCATTCTCCG TGCTACTCAA GAAGACAGAA 25441 TTGCTAAATT GCCTGGTGGC AAGACCCAAT ATGTCCATTC AAGTGTTTAT CCCTTCCCAA TCTGCCATCT CATCCTACCT GCAGATTCTT CCCTTGAGGG ACAGCTGCTA ATACTGTAAA ACTATGTGCC ATTACAGCTC ACAGCATCAT CTCTATGAGA ATCCACAAGA GAATTTCACT TTGGTCTTGT TGGTAGGAAT TGTGCAGCCT CATCTGAGTA ACTAATGTGT TTTTATCTTA CAAACACAAG GAATATCACA TGGTTCTCCT TTGACTGGCT GTAAGGAAAC TCAGAGCTAG ATCTGAGACC CTCTCCTACC AAGTATATAA AACTTTGTGA CATACATTTT TGTGCCATAA CTTCAACCTT GGTTCCAAAT GATTTTTGTA CCCTAAGTTT AAATTTGGCT TTCTTTTTTT TTTTTTTGTA CTCAATAAAA CATCAAGCTC ATTTATTATT GCGAAGAGCG AAACAACAAA GCTTCCACAG CGTGGAAGGG GACCCGAGTG GGTTGCCCAA ATTGGCTTCT TTTTCTTACT TTTTAATTAA TTTTAATTTG CTATACTGAA CACATTTTGT ACTGTTCTCA CATTCTTTTT GAAAAAAGCA GAATATAAAT AAGTAGATAA CTTAAAAAAA ACTCTTTGAG CAGAAAGAAT CATTTGGGAG GCAATATATT TCAGTGGCTG TAAAGTGGCA TTCTAGAATC ATCCTACCCA GGTGAAAGCC CTATTTTGCC ACCTGTAGTG TAGTGTGTAT TTGAACAGCT ACTTTCTTTT CTAAACTACA ATTTCTTCAT CTGTTAAAGA GGCATAATAA TTGTATCATC CTCATTGGGT TGATAAAATA AAATATTTCC AAGTATTTAG TTCAGGTCCT AGCACGTAGA CAGTGTTGCA TTACTGTTTT AATCCTTTAA AGTATTAAAG ACTACTATTT GAAATCTTTT CTTCTAAAAT TCAGCCTGCT GATGACCAAG TGCACTTGAG CAGGGGGAAT CAAATCTGAA TTAATTTCAG ATTCTGGTTA GCTTCACATA AATATTTTTT TTAGGGATGA TGAACCTAAC AGCAATAGAT GAGTAAGAAT CTGTTCCTAC TGAGAGAGTT TCATTTTGAA GAAAAAGGAA CTAAGGGGGC ATGTGTTCAG TTTCATCCCC TGGTCTAACC CTGTGTGTTG GTTCTGGTGG GAAATTCTTC CAACCGAGGA AAAAACCAGT TCACAAATCT GAAGACCAGT GATTTTAGAA GATGTATCTG GACTGGAGTC TAATCTCTGA CTCTGGGTCC TGCTGATATG GTATTTTTGA GATTTGGCCT AAAACATCAT TGCCCTGGTT TCCTTATTTA CCAAACAGGG CCAATGGTAG TGACTAATCA GAAAATGATA ATGCCTGGTG CACAAAATGT GTCTAGATGA EPI-109 154

GCCCATGCAC AAGGACACAT GTTTCTGGAA CTGTTCCTTA TTCCTTTCCT AAAAGAAAGG AGGGAAAGTC TCCATACTAA GACTACTAGG GCAGGGGACA AAGTGCTAGA GTCAGAAGAT TCATCTGAGG ACAGAAGAAT AGGGGTGAAG GCTCTAGTCA CTTCATTGGC TACCATGCTC TAAATAGTTA CCTGTGCCCT TTTTCTAACT ATTAGAACCC AAAAAGCCTA TAAATTCTCT CTCTCTCTCT CTCTCTCTCT GTGTATATAT ATACATATAC ACACACACAT AGACACACAC ACACACCTAA ACACACACAT AGAGATTTAT GACTTTTTAC TTTTATCCTT GTAAATGCCA TTAACTATAT TTTGTCTTAG ATTTAGCCTG GGAATGTAGC CATTATTTCT ACCATTGCCT CCATAGGAAA AATACTCTTC ATGTTTTAAA GGACCAACCT ACAACTAAAA TCTTTGGAAA GCAGAATCAT TTGTAAGTTG GTGAAAATGG AAGATGTTGT TTTATAAATG AAGACTTTTT TTTTTTTTTT TTTTGAGACA GGGCCTCACT CTGTTGTGGA GTGCAGTGGT GCTGTCATGG CTTACTGCAG CCTTGACCTC CTGGGTTCAA GTGATCCTCC CACCTCAGTC TCCTGGGTAG CTGGGACTAC ATGTGCATGC TACCATGCCT GACTAATTTT TTGTATTTTT GTAGAGATGT GGTTTCGCCA TGTTGCCCAG GCTGGTCTTG AACTCGTGGG CTCAAGTAAT CCTCCTGCCT CAGCCTCCAA AAGTGCTGGG ATTAGAGGTG ACAGCCAAGG TGCCTGGCCC ACAGATGAAG ACTATTTAAT GTTATCTTAA AGATACCCTA AGCTTCCTAC CAAGCCAGTG ATCTTTTGGG GCTTCTGTTT TCTTTGTTGG CATAACTGTA ACTAGCCTAA CTGCCCGTTA TCTGTTTCCT GTTTGCCCCA CACTGATTCC CACAGCAGTT TTCAAGTTAT CGGTTTGAGA TCTTGTACAG AAATGACTCC AAGGTAAAAA ATTTAAAAAC AACCCCTCTA ATTTTTTTAC CCTTGCTTAT AAAACAGCCT TAGCCAGCTA ACCCCTCACT ACATGCAAAT GAGTTTGATT CTATTCTTTT GATTCTACAA ACACTTATTA AAAGATTTTA GAATTCGGAA ATAAATAGCT TCCTTATTAA GGTGACTTAC AGCCCCAAAG TCCTTAAAAT TATTTAGACA ATAGCCACCT TATCCCAGGG GGCAGTGTGT AATAACCCAC CCTGTTCTCT ATCCGTCAGT TCTGCCATCA TCGCCCAAGG TAGGAAGAAA GACAGGACAA CCGGGGTCAA GATTTCAAGT CTCAATGGAA AGAATAATCA GTGGTTGGAG AAAACTGTCA TTCTTCTTTT GCCTTAATGC AGTACTTGAT ACTTATACTT AGTACTGTAT AGTACTTAGT ACTGTATAAT ACTATAAGAT AGTGAGATTC AATCAGCACA GAATTTCTAA TAGCAAGGGC AGAGACATTT TAACTGCTCA GTGCTCTCAG GTTATACATA GCTAATGAAG TTCTTGCATA TCAACAATCC CCACCCCCCT CACACACTTT GTCTTTCTGG ATTGGTTAGA AAACTTACCT AGCGCCCACT ATTCTCAAAT TTAAATGAAA GATAAGATCA GAGTGGCACG CAATTAGGGA CTGATAAATA ATATTTTTGT AATTGCCAGT GTAAATGGAC AGGGGGCAAC CTTTACATAC CATATTCAGT GAACAGAATA CGTACTAACT AATTTGATGG AAGGAAAATT AAAATGACAA TCAACTGAGC CCACAGAAAG GCAACACAGA GCAGTTGGTT AGCAATTGTT TCGAGATCAT CCCTGAACTT GAAACAGGTA TATCTTTTTT TTTTTTTTTT TTGAGACAGA GTCTCACTCT GTCACCAGGC TGGAGTGCAA TGGTGCGGTC TCAGCTCACT GCAACCTCCG CCTCCCGGGT TCAAGTGATT CTTCTGTCTC AGCCTCCCGA GTAGCTGGGA TTACAGGTGC CCGCCACCAC GCCTGGCTAA TTTTTGTATT TTTAGTAGAG ACAGGGTTTC ACCATGTTGG CCAGGCTGGT CTTGAACTGC TGAGCTCATG ATCCGCCCGC CTCGGCCTCC CAAAGTGCTG GGATTACAGG CATGAGCCAC CACACCTGGC CAAAACAGGT ATATCTTAAA AGCTGCCCAA TGTCCATGAA TGTTACAGCC TTGAATGGTT CTTCCAGGTG AGTTTGGCCA AATGTGGCAC CATACACCCA AGGCCTGCTG CAGGCTAGTG GGTTGCTCAC ACTTTAAAGC TGAGACACAC TCATGCCTTA AGGTAAAGGG AGTGATAATC TGGGCAGCAG ATGTTAACTT CTCAAGGCAG TCCTCCTTCT CTTTTCCTCT CCAGTGACGG ATGGTTGGAA AGCATATATG GTGCATTTGG TTAGAGCTGT GGCCTTGGTG AATAGATACT TGGGAGAATA CATGGGAATT TCTCCCAGGG TTAATGCAAT GCCCATGTGT TGGGAACCAG GTGACTCTTG AAGAGGTCAG GTATTTGGGA GCAGTGCCTT GAAACCTTAG TGGACATTAG ACCCACTTCC TAGTGGAATT GTAGCATTGA AATCCAAGGC ATGTAGGCTC TTAGAGGACA GAGATAGTGT GTCATTTTTT CAGAATTAAT TAAGAGCAGG CCAGGCGTGG TGGCTCACAC CTGTAATCCA AGCCCTTTGG GAGGCCAAGG CAGGCAGATC ACGAGGTCAG GAGATCGAGA CCACTCTGGC TAACACAGTG AAACCCCGTG TCTACTAAAA ATACAAAAAA TTAGCTGGGC ATGGTGGCAC GCTCCTGTAG TCCCAGCTAC TTGGGAGGCT GAGGTGGGAG AATAGCTTGA ACCCAGAAGG CGGAGGTTGC AGTGAGCTGA AATTGCACCA CTGCACTCTA GCCTGGTGAC AGAGTGAGGC TCTGTCTCAA AAAAAAAAAA GTATTAAAGA ATTACATAAG AGCAAAGAAC CATTAGAATA TCTCACTTAG TTGTTATCAG CCTAGCAAGC TGCCTTGAAG GTAATAGACA TTTTTAAAAG TTTATCAGAT GAAAAGCGAA AATCAGCCAA CCTGTTTTAA TGAAGGTGTG TCCTGGGCTG ATTTACATGT CTCCAGGGAC TGATGGCTCT AGAATGTAAA GCTTGGCATC CTGCTTGTGT TGAATCTATC ACATTTAATT TCCTGTGGGT TTCTTTTTTT TTTCTTTTTC ACTTTAAAGT TGTGTTCTTT TCATGTGAAG TTAAACTCAC ATACCTTTTT TTAATCTCCT TGCCAGCCAA ATGATAAATG CCAACCCAGA GAATGCAGTA ACCATGACTG CCACTGGAAT GAAGAGGGGG TTATAATCAC CCTCCTTAAT CATTGAGAAA CTTTTGTCCA ATTCTGAAAG AGAAATCAGT AAGGCACATA GCATGAGACC ACCAGCATTA TTTCCTTAGT CTATCTCATG ATATTTGACT TTTTTCCTCC TTACATCTCC CAGTAGTAGC CCATTTGATG CCATTTGACA GATGAGGAAA CTGGCATGGG AAGGCCCCTG ATGAGTCTAC AGCATAGGCA AAGACTGGAC CAGCCTTGCT AGTCTAATGC CTACAGAATC TCAATGCCCA GATTTGTGGT TCATAGAGTT CCTGAAAATG CACCTAAAAA TGTTGGCAAG AATGGTCATC GTTGTATTTA GCTCCATGGA CTTGTTCAAT GACTGGAACT CTGAAACACA GAGAAGAGCT AAAAGCCTAA TACAACTTCA GGAAAAATAA AAGCCAATGA TCTGAACTGG ATAATTCACC AGTCAAAGGA AATCATTAAT GCTTTTACTT TAAAGCAGTT GTGCAAAAAT AAGCACTTGA TTTTTACATG CCAAGGACCT GCACTAATTT CTTTCCAATG CAGTAGTTAC CACTTCCCTC TACTTCCTTC ACGAATAAGT AAAAGGGCAT GTTTAGAGAT ACTCTTGTAA GTGTAAACTA AGTTCATTTG GGAGCCTCTA TTTGAAAATA CTGGTATAAA AAAAAATCTG TCTCCTGATA CTAACATTTG AAGGAATCTA CTTTTTTACA TATTGGCAGA GGGTCTGATT CTATCCTTAG TTCTTCCCAT TACTTTGATG AACCTTTTCA AGGTGATTTG ATCCCCACAC CCAAATATAT GATTGAGAGA AGGCTCAAGT TCCCAGGAGC TCCAGACAGA AGGTACCTGT TGGCTTGATG AAGATGAGGA GGAAATGAAC ACTAGCTAGG CCTTAAAGGG AAATGTCTCT GATAGGCCTA ATACACAGTC CTCTGCTAAA GGCCTCCCTG CCTCTCTCTG CTCATCCACT CTACTCCCTG GCCCTGGGCA CGCAGCACAC AGAGATCAGC ATTTCTGACA GCTTCTGTAG ATCCTACCAT TTAAAGACTT TTGTCATCCA TGCAGATAGT CTCAGGAGCA GACACAGGTA GCTATTCTTT CACATGCTAG CTTAACATGC ATTTGCTTTA GCACCTATTG CCAGGCACTG TGTCAGGTGG AGGGTATACA AAGATGAACA AGACATGATT CTTCTCATAT ACAGATAGAT TTTGGAGGCA TTAGCTTAGT GATGATTCAG GAGTATCCAT TATTTGGGGA AGTAGGTGGT CATTAGTGAC CTTTTACAGG CATTTCAATG GGCTAACAGA GATGTTAGAT TGTAGTGGAA TAGAAGAATG GGTAAAAAGT AAATCAGTGA GTTCAGATTT TAGGAGTTAA GATGGCAAGA GGTGAGAACA AAAAAAGGAA ATGATTGTCA TTAAAGGAGG AGGAAAGACC AGCCAAAGAT TTTACAGTGA GTTAAGCATA CAAATTTATT TCTAGGCCAC ATATTCTTAG CAAAACAACA TGTAAATGTT TATGTATGTC TTTCCTCATA TCTGCTCATC CATCAGCTCC ATCGTTAAGA TTTCAGTTTT CCAGGACAAA CTTACTCACT TTGACATATT GGACTAGGAT TTGACCAGAT TCCAGATCAT TCACAAATGG TTTTCTTCTT CCCAATTAAC TCAGTTCCTT CTGAGCAGAT GAAGGTACAT GCAGAGGTAA AGCTGAAGCT GGCCAGGGGA TGGCTACAGT TCATGATCCC CAAATCTGGT GCTGATAGAG GCTCACACTG AATCACTTCA ATGAAAAAGA AAAAAAAAAA AAAGACAAAA CAGTATTTCT GAGTAGAGAC CCTCCCTTGA GCAAAGGATT TTTAGCCAAA GCTGCCTGAC TACATTACTT GTGATATTGC TTCCAGGCTT TATTTTCTTG AGAATGATGG TGGGTGGTGA ATGAGAGATG AAGGCAAGGA AGCATTGAAA GCTGTGGGGA GAGGAGTAGC TACTCCAGGC TGCTGCCCTA GCTAAGGTGA CCCTCCCCTT CTGCTGGAAG TACCATGCCA TATGGCCTCT GCATCAAGGG CTCTTATGGG ATATTCTCAG AGAATCTCTG CCGTTTCATC TGTTCTGATA TCTACCCAAG CATTTTGAAA AACATCCCAA TTCACTGAAG CAAGTCCAAC TTCCGTAAAT TCCAGTAGGT GGGTTGACAG TTTTATAATT TCAATAAGGG ATTTTGATAG CACTTCTAAG AATTAAACTA CTTAAACTAA TGCATCAGGA GCATACTTGT AGAAAAGTTA ACCAAAACTT CGTAAGTTCA GATGACATTG GTTTTCTCCC ATATGGAGAT AAGGTTGGCA GTTAAAAATG AAAAAAAAAA AAAAACCTAC CTTATTTCAA ACTTGAAAAG ATCAAGAGAT TGTGTTTTTG TTTTTCAGTT GTTATTCTCC TAAAAGTTTA TGCATGAGGA AAAGTAAAAG TGATTTTAAG AATAAGCCAA ATAAAACAAC CAAGAAAGAC CTCCACTACC CTGGGAAGGA AACTGGTTGG TATTAAGTAG GACACCACAT AAAACAGGTG TTATTGAGAG GAGAAGAACC AAAATGTAAC TGAGGTTCAA CAAGACATTA TTTATGCAAT GGCAATGAGA AAAATAAAAA ACACAGTATA EPI-109 155

ACCATGCTGT ATTGCTATAA GTCATGTTAC ACACTGGGAG ATGGCTTCAG GGGTATTTGG TTTTTACTTT TTGTTTGGGA GGTTTTTCAA AAAAATTTAG TTAGAATAAG TCCTTTGAGA AACATCACAG TAGGTTAAAC AAAGTTAGGT TAAATTAGGC TCCTAAGTTT GACTTCTCAG CAAACTTCTA CTGAATGTTC TGACTGTAAG CCCAGGATTG CATGACAAAA CCTCTAGTCT GAAGTTACTC ACCTTGACAG GTTGGTTCTG GAGATGACCA GTTTCCAAAT GGTCCACAGG TGGTTTCTTC AATCCCAGTT AAGTTTGTTC CTTCAGAGCA GCTGAAGGCA CACTGTGAGC TGAAGCTGAA GTTTCCCAAA GGGTGAGTAC AGTCCATGGT ACCCAGCTCT GGGGCCTCCA AAGGCTCACA CTGAATCACT TCAATAGGGA AAGAAACAGT ATGGGGAAGA GTTAAGAGGA ACTGACGCCT GGATTTGAAT CCTAGCCCTG CCACTTGATA ACCATGTGCC TTTAAACAAG GTTACTTGAA CCCTCCAACT TCAGTTTCTT CATCTATATA AGAGGAATAA TGAAATTGTG TTATCTTTAT CAAATTGATA TGGAAACTAA ATGTAATTCA ATTAGCATAA GTCAAGGACC TTAGAACAAA GCCTGACTCA TCAGAAATTC TAAGTAAACA TTAGCTAGTC TTCATATTAT TATCTTCAGC ATTATCTGTA GTGAGAATCC TTAAAGCCAA ATAGGTGTAA CTGGGAATGA CCAGCTTAGT CGGGAAATAA CTATCACATC AGAGCCCCTG AGTCTACTAG AGTATTGGGA GCAAGATGTT CAGAGAAAGA GTGGGTCTCC ATAATAAGCC TTCTTTGCAA GGAGAGAATA TAAAAGTCTA GGAAGCATTT TGACCTCAAT TCTGTCTTCT ATTCTAGCTC AGTTCCAGAA TΠTAACTCT TTTGATTTTG ACAACCCTCT CCAGAAACTG TATCTATTTC CCTGTTCTGA TTGGTGGTAC AATAGGTAAA TTTAAGACTT GGAAATCAAA GTTTTCACAT TTTAGACCCT GCCATGCCAT TTAGTAAACA GTACAACTTT CATGTCTTAT TCCTCATCTG TCAAATTTAA GCCATTATTG CTACCTTGCT CTAGAGACTT CAAGGAAGAA TGGACTCAAG GAATCAGAAG AATTTTTGTA TTTGGAAACT ATATGAGATG AGATTAGGGA GAAACATGGG AACTAAGAGA AAATGTTATC TTTTTTCATT GATTTAAAGA GTATCTATTA TATATCAAGC ATTACTCTGG GGCTTGAAGA GCTTAGATTT CACCCTGTAG GACAAAATGG TAGGTAGAAA TTAATGGGTG GATTGTCATG TATGTGTGAT GTGTTTTAAT TGCTTTTAAT TGATCAGTCT CCCTGTAGTA TGAATAATGT ATTTGAGGGG AGCTAATTTA AAATTGTGGA ACTCATCTAA TAAACTATTG CAAGAATCTA GAAGAAAGAT AATGACGGCA ATGGTAGTAG AGTTGACAAG TGGAAGACAA ATTAGAAAAA CACTAAGTTG TAAAAATTGG TAGAATGTTA CCCTGCATAA ATGTTGGGGG AGTTAAGAGA GTCTCATACC AGGGTGCCCA TGTAAATGGT GATTCCACAT ACTGAGATAA GAAATACGAA GAGAAAAGCT GACTGGGAAC AATTGGTTTT ATAGTCTTTT AAACATCCCA AAGGACATCC TTAGCATATT TGAGTTCAGA GCTGGAGATA GGCTTATCAG TCCAAAGATC ACATAGATTT GTGAGTCCGC AAAAGTCAGT AAGTTTGACC AAAGGATACA TGTAGATTAG AGTCAGAAGA GCAATATACA AAAGACAAAA GCTGAGAAAT TATAGTAGTT TATGGTCCTG GATAAGTGCT CATGAAGGAT CTCAGGAGAA ATGATCACAG GTAGAAAGAA TGAGAAAAGA GTGATATGAG AGAAACCAAG ACAAAGAAAA GTAAAATGTT AAAAATGAGT GAAATAGGCA TACCAATAAT TAAAAATGAG TAAAATAGGC ATACCAATAA CATAAGGGTT AAAAAATAGA GTTCAAAAAT GGGGTGAGGG TAAAGTATTA GGAAGGAGTC ATGGCCCAGG GATCAAGTGA AATGAGTTAG ATCTATAGAT CTATTTCAGT TGGTTGACAT TTAAATGTAT TTTGGTTTTA ATTCTTTATT GTTTACAAAC ATTGCTTTTT TAAAAAATTA AATTGTCCAA TTCAATTCAG GCTCACAAGC AAGTGCCTCA TATATACAGG CATTTTGTGG ATCCCAAAGA TGCAATGATA AATAGGACAC TTACTGATCT CAAGAAGTTT TCAGTACCAG AGGAGACGGA CAAGTGAACA GATGACTTCA ACATAAGTGG GAGAAATGAG GAAGAAATAT GTGGAGCTAT CAGAACTAAG AAAGCTTCCT AGAAGAAACT GTCTTTGAAC AATGTCTTAA AGATGACATG TTTTTTGGCC ATGTGCAAAA TGAGAGAGAA GGCCACCAGC AAAGTCAGTG TGCTACAGAG CACATGTGTT AAGTGTGGAG AACTGCAAGA AGGAAAGGAA CTACTAGAAG GAAAAAGCAA GATACTTTCT GGGTAACTCA GCCTCCTAAT GATAAATGGC ATAGTTTCTT CCAGACCTTA GAGTTCTAAT TAATCTAACA AGCTCATTAG ATCGTGAGCT TCTTGAGAGC GGGAATCTAC CATGCTAATT CCTTATGGTA ACCCTGACAG CTTTTATCCC AACACTGTGC TTCTTGTGGT ACTCAAAAAG ACTTGTTGAG AAGTGAGTCG AAACTTCATG CTGACTTATG AAATCTTTAC GGAAAGGTAA CAATATTGTG AAAGCAGAGC TTTCTGATCA AAACTTCCCA TTTCTCAGAG TGGCTAGTAT CATTTTGTTC CAACCAGCTT CATGATAAGC TATAATGATT CCTGTGACTT TACCTAAGAA GAAGCAAAGA AAGGAAAGAG ACTTACCAAA CTGACACTGG GGCCCATAGT ACCCCACATC ACAGTTGCAG GTGTAATTAT TGATGATTTC TACACATTCT CCATGGCCAC TGCATGACCA GGGCTGGCAA GAAGCTTTAA GGAGGTCAGA AAAAAAATAT TTTAATGTGA TTACATTTTA GTACTCAAAG TCATTTCTTT AGACATAGAT AACCTTTTGT CTGAGATGAT TTAAATAATC AGGAAAGGTT TATTTGTAAA TTCATAGCAT AAAAATCATA TGCTAAAATT TTTACGTATA AAATACACTA AGCATATAGT CATAGGCATT TATTTGCTTT TGGAATGAAA TTACCAATAC TAATATTCTG TAACACTTAT AGGAAACTTA GTGGCATACC TTGAAACTCT TGAAATTACT TGTTTTTAAT GAGTGAGAAG GTTAAATGAT GACCTGACCT CAATCATTTC TGCATGCAAT TATTTCTTGG CAATCCCTTT CTTTATAGAA ATCAAAGATT AAAAAGTCCA AATTTGCTAA AACGGTAGAG TCCAATTTAT AAGAGACCAA ATTAACTATG GTTCATTATT AAAACATCAC TTGGAAAATG CTGGCTGTTT TGGAATTGTA GAAGATTTTA CAGAAATATT CATACACCAA AGATAGTGCA ATTTTTATAT AAAATTATAT AAGGTTAGAC CAAGAAGGAA GCACGCAGCA CCACACTCTC TACTTCACAA TGTGAAAACT GAGGTGATGT GAGCCTAAGT TTCCAACTGG CCCCAGCTGT CAGCTTCTCC TCCCCTGCCT TATTATCAAA GGCACTGATT GTCTAGCTCT TCCTCTGTAC TTCCTACGTA GATCTATCAT TTTGATGTAA CTTGATTTAG GGGTATAGCT TTTGTGCACA GGGACAAATC TTACACACCA AAAATTCTTA GGAGTGACAC GATGCAAGAT TATATAGAGG GCTAGATGTA TTTTAGAATG AACCAGAAGC TGTTCTCATC CCCCCACCTT TCCATGGGGT AAATCTGAGT ATTCTCTTAA CCGTGGCCCT TCCTGAGTCT GAGGCAGCAT AGCCGTCTTG TCACTCCCTA CCTGTGTAAC AGAGGGCTGC CTTTAGTTTG TGGCAGGCGT CATCGTTCCA TTTGCCTGCA TCTTTGTTTC TCTTGATATA GATCTCCACG CAGTCCTCCT TGTTCTTCTT GTTGTTGGGC TCACCATCTC CCCAGTTCTC TGCTTCTTCA GTAAGAGATT TGTTGGTTCC CACCCACGTC CATATTCCTC CTATCTTCCG GATTCCTATC CAGTAGTAAG AACGACTGAA AGGCAGAGTC TTCTCCAGAT ACTCAATTTC CGCCTTGTTT TGTATGGCAA CTAAATCTGT GTAATTGTCT CGGCAGAATC TTCTAGCCCT TTGCCAGTTC ATGGGTTT1T CAGAATAATG GTAAGTCCAG CAGTCGGTTC CATGATGTGC CAGGAAATCT GCAAGACATC AGTGTGACCT ATGCAGACTT ACATAATGTT ACAGCTAAAA AGAACCTAGC ACTACTCCAG GCTGAGCTAG ACACTTAGAG ATGAGGAAAC AGAGCCTAAG AGTGTATGTG ACCATCTCAG GATCACAGAA TAGTTGTTTG CAGATTTGAA GTAGAACCTA GACCTTCTGG CTTGAATATA AGATGCTTTT ATCTAAGGTT CTATTTGAAA CAAATTTAGT GGTTTTCTAG GTTTATTTTC TTATTAATTT TTTTCTCAAA ATTATTTCAG GTGAAATTTA ACCAACATAT TTTAGACATT CATATTTCTT TTTCTTTGTA GCTGTTAATG ATTTACAACT AATTACCGTG TAATATCATA TAACTATACA ATTTACGTAT ACTTTTTAAT CCTGGAATCA TTTCTTGAAG GCCAACACAT ATGTACCTAT GGGAGAAGCA TAATAAGGAC AGGAAGAACA GTGACATACT TTTAAGTAAC CTCTTTTACA TAAAAAACAT TTTATTTTAC CATAGGAAGA ACTGCTTCTG GAAAAGCCCA ATATACCACT CAACTCTTAT ATATCTAACT GTATAATTTT TAAAAAGAAC AATTTACAAA GCCAAATGGT ATAGGATTAT GAAATTCATT AGATCATGTT CTATACACAA AGAGACTCAA CTGATGATGT TTAATAAACA TATGGACCCA TCAAATATGA GGGCTTTGAA GATATCTAAT TAAACACATA ATTACACAAT GACTTCATAA TAATATATGG CATTCTAAGC ATGGTATGAT CTACATGAAT CACTATTTAA TACAGTAAAG AAACAGATAT AATTGATGGT AAAGAGCATC ATAAAATAAA CATTTTGAAC AGAGTTTTGA ATGAGCATTC CACTAGAATG CAAGTTCTAA GAGGGAAAAA ACTGTTGTGT CCACTGCTGT ATCCTTAGTG CCTAGCATAA ATTTCACACA TTGTAGGGAC TCAGAAAATA CCTGTTGTAT GAAAAGAGCA CTAAGTTTCT ATGTGACACA GTGCAGACAT GGCATAAGGA ATGTGTGAAC GGGAGAGTTA GCATGTTTGC TTGGCTAGAG CTGAAAATCC AGGCTAGGGA GAAAGAAGAC ATTAGTTTAC TTAGGAAATG AAAAACCAAG TTCAAAGCTA TTGCTGGAGA GTCTTCAAGA ATCAGATATA AAATTTGTCA CAACAATGGG AGAAGGACCA AAAAATGATA AACCCCCGTC CCTTAATAAG CTCGTATTGT AATTGTAGAA ATGACATTAA TGTACACTGA ACTATGAATA AAAAATAGAA AATGAGGTGC TAAATATTTG GTACAGATTG TAAGTACCTT AACAGAGATT TCTTAATTAA CATTATTCCT TTATAATTGA GGGATTTTGT GGGGTTATTG GGATTTGAAC TCTACAGCAT GGGCTATTAT AGGTTAAAAA TAGTGTTCAG GAGTTTCTGG GGAAGAACTA AAGGTAAGAA GAAAAGAGAT GTTTACAGAA GGGATAGAAT TAACAGCTCT GTGAAATAAT TTTCCCTTAG ACTATGTATA ACTAGTGGAT ATTTAAGAAA AATGAATATA bPl-109 156

AGTAAAATAG ACTTAGCGAT ATATAAATAT CATAACATAC CACAACAGAG CATTGTCCAC CCCCACAACT TGAAGATGTT CCATAAGTCC CTCTGGGTGC TCTGACATTT CCATGGAAAT ATCTGCAAAT GAAATACAAA ATTATATTTA GATGTATACT CTTAAACCAC ACATTTATAG CCTTTGAGGT GGTGCTTACA ACTTTCTTAA TAATCAGAAT AAAACACATA TGTCTACTAA CCCTGTCTGA GGTAACAGGT TTCTCAGACA TAGATGAAAA ATTACTTCAA ATTTACATCA GAACTGATGC ACAGTTTTGT TTTGTTCTAT TTTATTTTTA CGCTTTAGTC TCAAGTTGCT AATCGGTACT GCCCTGAATT TTTTCTATGG TTTGGTAATT TTTATACCTG CTTTTCTGCT GAGCTATTAG ATAAAACTAT TTAATATTTA CTATGTATAT TTTTTAAAGT ATTGTTGCTG CTTAATTAAC TATTGATGCT TATATTTAAT GTTATAGCCT CACTCTTGAT CATAATGGGT CAATGCCTCA AATACCTAAA AAAAAAAAAA ATTAGATAGC CAGACACCAG GAAAGAAAAG TATTTCTTTT TTTAATAAAA AGAAATACCT TTTTGAGCAA CTGAAATGAC AAAGTCACAA ATTTCCTGCA CACCTTAAAA TATACTTAAT GTAAATGACG AGTTAATGGG TGCAGCACAC CAACATGGCA CATGTATACA TGTGTGACAA ACCTGTATGT TGTGCACATG TACCCTAGAA CTTAAAGTAT AATTTTAAAA AAATTCTATC TTCCAAAGCA TATCACTTCT CAGGTAGACA CAGTGTTTAT TGCAAAAGAT CTGATTTCAA TAGTATTTCT TCAAGAGTCT CCCCAGAGAC AAAGTCAAGA AGAGGAAATC AGCATATCTG AGAAGAAAGA TTTCAGGATC ACTTTTTTTG AGGGTCTGAG AAAATGTTTA GTTTCTATAT TATTTAAAAC CAGAATTGAA ATGGGGTGAT TCCTATCCTT GCCACCTGCC TCTACAACCC CAAGAGTTTC TATCTGAGCA TCTAAACGTC TTTTAGGCTG AAAGGCTCAC CATGGCTTTG CTTGGTCCTT CTCTAGTTCT TCTGCAGCCC ATTGAGCCTC TTGACTTAGC ACAAGGGTCT CAGGTCCTTG CCCAAAGGGA GTGTGCTGTG CTGCAGGTAG ACTGCACTGA ATGTCAACAG AAAGCCTTGC TTTCTTTCAT TTCTCTAACC CAGTCTCACA TCCTCCTCCT CCTCCCCTTT TCCCTCCCCT TCCTCCTGCA CTTCTCTTTC CTCTTTCCCC ACCCCTTTCC TAGACTGGCC TCTATTGCCT CCCACTGAGA CAAAAATGAA CTGCTGATCA GAAAGTAATG TGACTAGATT CTCTCTTCCT TCCCTCCTTT CTATCCTTCC TTCCATTCTC CTATGCATCT TTCCTTACCC TCCTCCTCCT TCACTCATTG TTGTTGCTGT TCTTCTTCCT CTTCTTTTTC CTCCTGCTCC TCTTCTTCTA CTTGTTCTTG TTCTTGTTTT TGTTTGGTTC TTGTTCTCCT CTTCCTCCTT CTCTCTCTCC TCCTCCTCCT TCTTTTCCAC CACCCTCCCC TATCTTTTTC ATAAATGCTA AACTAACTCT TGGCTACCTG TGGTAAATGG CCCTTGGAAA TTGCAAATAC TACAAATCAA AACTGCATTT CAGACATATT TATGATGTTT GCAAAACTTC AGTAGAGCTA AGCAGTGGAC TTGACTCGTT TCGGTTCCTT CACCTCCGTC TTTCCTTGCT CACCACCTAG TGGACGTCCT TGTTAGTGGC ACTTCCTGAA GTTAACCCCT GAAGAGAGCC CATGCTCTCT AGCTTTTCAC CGTGTAGGTT TGGGAGCCTA CAAGTACCTT TAATATTCTT GGACTATAAA ATGAGATGGT TTTATAAGAC TGCATGTGAA ATTAGGACCC ATATGATGAA GGACAATAAA AAGGAAGACC CACTGATGTG AGTCAATGAG TCAAATGCAA ATCAGATTTG CATTTTTAGG AAAATAATAA TAACAACAAC AAAAACTCTG AAGCTCAGCG CCCCATATTT ATTATATTGT TTAATCTTTA TAACAGCTCT CTGCTATAGA TATGATTATT ATCCCCATTC TAAAGAGTCT CAAAGAGGTT AAGAAACAAA TTCAAAAACT AGCGAAAGAC AAGAAATAAC TAAGATCAGA GCAGAACCAT AGGAGGTAGA GACACGAAAA AGCCTTCAAA AAATCAATAA ATCCAGGAGC TGCATTTTGA AAAGATTAAC AAAATAGATG GACCACTAGC TAGACTAATA AGAAAGAAGA ATCAATAGAC ACAATAAAAA ATGGTAAAGG GGATATTACC ACTGATCCCG TAGAAATACA AACTACCATC AGAGATTACT ATAAACATCT TTACACAAAT AAACTAGAAA ATCTAGAAGA AATGGATAAA TTCCTGGACA CATACACCCT CCCAAGACTA AACCAGGAAG AAGTCAAATC CCTGAATAGA CTAATAACAA GTTCTGAAAT TAAGGCAGCA ATTAATAGCC TACCAACTAA AAAAAGCCCA GGACCAGATG GATTCACAGC CAAATTCTAC CAGAGGTACA AAGAGGTGCT GGTACCATTC CTTCTGAAAC TATTCCAGAG AATAGAAAAA GAGGAACTCC TCCCTCACTC ATTTTATGAG GCCAGCATCA TCCTGATACT AAAACCTGGC AGAGACACAA CAAAAAAAGA AAATTTCAGG CCAATATCCC TGATGAACAT CATTGCGAAA ATACTCAATA AAATACGGCA AACTGAATCC AGCAGCACAT CAAAAAGCTT ATCAACCACA ATCAAGTTGG CTTCATCCCT GGAATGCAAG GCTGGTTCAA CATACACAAA TCAATAAACA GAATCCATTA CGTAAACAGA ACCAATCACA AAAACCACGT GATTATCTCA ATAGATGCAG AAAAGGCCTT GGATAAAATT CAACACCCCT TCATGCTAAA AACTCTCAAT AAACTAGGTA TTGATGGAAC GTATCTCAAA ATAATAAGAG CTATTTATGA CAAACCCACA GCCAATAGCA TACTGAATGG GCAAAAACTG AAAGCGTTCC CTTTAAAAAC TGGCACAAGA CAAGTATGCC TCTCTCACCA CTCCTGTTCA ACATAGTATT GGAAGTTCTG GCCAGGGCAA TCAGGCAAGA GAAAGAAATA AAGTGTATTC AAATAGAAGA GAGGAAGTCA AATTGTGTCT GTTTGCAGAT GACATGATTG TATATTTAGA AAATCCCATT GTCTCAGCCC AAAATCTCCT TAAACTGATC AGCAACTTCA GCAAAGTCTC AGGTTACAAA ATCAATGTGA AAAAATCACA AGAATTCCTA TACAGCAATA ATAGACAAAC AGAGAGCCAA ATCATGAGTG AACTCCCATT CACGATTGCT ACAAAGAGAA TAAAATACCT AGGAATCCAA CTTACAAGGA ATGTGAAGGA CCTATTCAAG GAGAACTACA AACCACTGCT CAAGGAAATA AGAGAGGACA CAAATGAATG GAAAAACATT CCATGCTCAT GGGTAGGAAG AATCAATATC ATGAAAATGA CCATACTGCC CAAGGTAATT TATAGATTCA GTGCTATCCC CATCAAGCTA CTACTGACTT TTTTCACAGA ATTAGAAAAA AACTACTTTA AATTTCATAT GGAACCAAAA AAGAGCTTGT ATAGCCAAGA CAATCCTAAG CAAAAAGAAC AAAGCTGGAG GCATCATGCT ACCTGACTTC AAACTATACT ACAAGGCTAT AGTAACCAAA ACAGCATGGT GCTGGTACAA AAACAGATAT ATGGACCAAC GGAACAGAAC AGAGGCATCA GAAATAACAC CACACATCTA CAACCATCTG ATCTTTGACA AAGCTGACAA AAAGAAGCAA TTGGGAAAGG ATTCCCCATT TAATAAATGA TGTTGGGAAA ACTGGCTAGC CATATGCAGA AAACTGAAAC TGGATCCCTT CCTTACACCT TATATAAAAA TTAACTCAAG ATGGATTAAA GACTTAAATG GAAGACCTAA AACCATAAAA ATTCTAGGAG AAAACCTAGG CAATACCATT CAGGACGTAG GTATGGGCAA AGACTTCATG ACTAAAACAC CAAAAGCAAC AGCAACAAAA GCCAAAATTG ACAAATGGGA TCTAATTAAA CTAAAGAGCT TCTGCACAGT AGAAAAAAAA AAACTATCAT CAAAGTGAAC AGGAAACCTA CAGAATGGGA GAAAATTTTT GCAATCTATT CACCTGACAA AGGGCTAATA TCCAAAATCT ACAAGAAACT TAAACAAATT TACAAGAAAA AACAAACAAC ACCATCAAAA AGTGAGTGAA GGATATGAAC AGATGCTTCT CAAAAGAAGA AGTTTATGCA GTCAACAAAC ATATGAAAAA AAGCTCATCA TCACTGGTCA TTAGAGAAAT GCAAATCAAA ACCACAATGA GATGCCATCT CATGCCAGTT AGAATGGCGA TTATTAAAAA GTCAGGAAAC AACAGATGCT GGAGAGGATG TGGAGAAATA AGAATGCTTT TTACAGTGTT GGTGGAAGTG TAAATTAGTT CAATCATTGT GGAAGACAAT GTGGCGATTT CTCAAGGATC TATAACTAGA AAAACCATTT GACCCAGCAA TCCCATTACT GGGTATATAC CCAAAGGATT ATAAATCATT CTACGATAAA GACACATGCA CACTTATGTT TATTGAGGCA CTATTCACAA CAGCAAAGAG TTGGAACCAA CCCAAATGCC CACCAATGAT AAACTGGATA AAGATGATGT GGCACATATA CATCATGGAA TACTATACAG CCATAAAAAA GGATGAGTTC ATGTCCTTTG CAGGGACATG GATGAAGCTG GAAACCGTCA TTCTCAGCAA ACTAACACTG GAACAGAAAA CCAAACATTA CCCATTCTCA CTCATAAGTG GGAGTTGAAC AATGAGAACA CATGGACACA GGGAGGGGAA CATCACACAC TGGGGCATGT CAGGGGATGT GGGGCTAGGG GAGGAACAGC ATTAGGAGAA ATACCTAATG TAGATGACAG GTTGATGAAT GCAGCAAACC ACCATGGCAC ATGTATACCT ATGTAACAAA CCTGCACGTT CTGCTCATGT ATCCCAGAAA TTAAAGTATA ATTTAAAAAA AGTTTAAAAA AAGAAAGTTG CCTTAGTCAC ATAACTAGTA AGAGACATGG TTGGGAATTT GAACAGAGGC CAATCAGTTC CAAATCCATG CTCTTGATCA TTAAGCTGAA CTTATGGCAG GAACTTGGAA GACATGGTAA AATGGGGAAA AACGTGGAGC CAGGGAGACT TGTGAAAGTG CCAGTGCTCC CACTATACCC TGAAAGAAGT ATCTAGACTT ACTTTTTTCT AAGTCCTCTC CTCTAATTCT CTCAATCTCT CTCTCTCTTT CTCTAAGAGA TGGGAATGCT GCTCTGTCAC TCAGGCTAGA GTGCAGTGGT GCGATCATAG CTCATTGCAC TCAAGGAATC CTAGGGTCTA GTGCCCCTTC TCCCTCAGCC TCCCATGTAG CTAAGACTAC AGGCACATGC CCCAACCCTC GACTAATTTT TTTATTTTTT ATTTTTGTAG AGACAGGATC TCACTATGTT GCTCAGGCTG TAATTCTGTC TTGAAGCTTG TCCAATCAGG CTTTCAGCCA CACCAATTCC CTGAGACTGC TCTCACCAAG GTCCTACACT TCACTAACAC AAACAGCCTA TTCTCCATCC TCATCTTACT TCACCAGGGA GCTCCTGGTT TTCCTCCTAC TTCACTGGCT ATTTCTTCTG TATCATGTGT TGATTCTCCC TCATCTCCCC AACCTCCAAA CCCTTGGAGT ACTCCAGAGA TCACCGCTTT GCTCTTCTGT GTCTAACCTC ACTAACTTGG TGGTCCAATT CACACTCTTG ACTTTGAATA CCATTTAAAT GCGAACGAAT TCTAAATTCT GTACAACCAG AACCATTCTC CTGTAGCCAA bPl-109 157

ATGCCTACTC AACATCTCCA TCCCCAAACA AATTTAGTTG TTCAATAAGC CTCTCATATT TTACATATCC CAAACTGAAC TTCTGAATTT CTCCTCCAAT CTGTAGGGCT CTTCCCACAG CCTTTCCATC TCAGTGGATT ATAACTCCAT CCTTCCAGTT ACTCAGACCA AAACTTTTGG AGTTAACTGA GACACCTCTC TTTTTTTTCA CAAGTCATAT CCAATGTGTC AACAAATTTT GGTAGTGGAA ATATTGCGGG ATTTTTTAAG AAATCAGAGA GACCGATGGG GTTCAGGAGG ATATTTATTA TTTAGGTGCA CTGGCCAAGT CAGATTAACA TCCAAAGGAC TGAGCCCTGA ACAAAGAGTT AAGTTACCTT TTAAGCATTT TGTGGGGTGG GAGAGAGGGG TATCTGTGCA GGGGGAAGCA TACTACAGAA GTGAGAAATA AAGACAGTTA TTCAATTAAT TGAGACATGC ATTACATCAT TTCTTACTTT TCAAGAAGAA ACATGTTTTG CGACTTGAGT TTATCTGTCT AGTGACCTTG CAGCTGCACA GCTAGAGAAA CAGGGTCTTC ACAATGCCTG GGAAAGGAGG AGAGGTAAGT CTCACTAGCC ACAGAAAAAC AGGCAGTTAA TTTTTAAAGG GCTCCAGCTC TTTCTCTTTC TCAGGGGGAG TTGGGTTTTG TTACATACAA CTGAGTTTCC GCTTACACAT TATTTAATTT CTTTTAATTC CTGTTCCAAA AGAAGCCAGA TACAAAAGGT TACATGTTGT CTGATTCCAT TTATATGAAA CATATAGAAG AGGTAAATCC ATAGAGACAG AAAGTAGATT AGAGGTTCCC AGGGGCTGAG GAAGAAATGG GGACTAACTG CTTATAGGGT ACAGAGTTTT CTTCTGATAA AAATATTTTG GAACTAGATA GACATTTTGT TAGGCCATTC TTGCATTGTT ATAAAGAATT ACCTGAGACT TGGTAATTTA TAAAGAAAAG ATGTTTAATT GGCTTACACT TCTGCAAGCT TTACAGGAAG CATGGTGCCG ATATCTGCTC AGCTTCTGGT AAGGCCTCAG GAAGCTTACA ATCATGGCAG AAGGTGAAAG GGGAGCAGGC ATATCACATA GCAAAAGCAG GAGCAAGAGA GGGATGTGGG GAGGTGACAG TCACTTTTAA ACAGCCAGAT CTTGTGAGAA CTCATTCACT ATCATGAAGA CAGTACCAAG AGGATGGTAC TAAATCATTC ATGAGAAACC CCACCCTCAT GATCAAATCA CCTCCCACCA GGCCCCACCT CCAACACTGG GGATTACAAT TTGACATGAG ATTTGAGTGA GAACACGGAT CCAAACCATA TCAGAGATGG TGGTTATACA ATGCGATAAA CGTCACTGGA TTGTACACTT TAAGATGGTT GTTTTATGTT GTGTGAACTT CACCTCAATA AAAAAAAATA TTTAATGTAC ATTCAGCCAA AAGAAGATTT GGAATAGGAA AGGTCATGGA GATATATTAA CAGCCATTTG ATGGGTGGTA AGGAAAAGAG TGGTTATTAG ACTGTTTTGT GGCCCTCAAA AGGTAGAACT AGATCGAGTT GGTGAGCATT ATAAAACCAT CACAAAACCC TGGAGAGAGG ACCCAGTGCT GAAGAACCGT TTGCCTGCCA TGAGACATGA GGGAAGTACC AGTGAATGCC ATTGAAAGCA GCATCCCTGG GTCCAAGGGA TGGTCAAAGG ACCACTACCC AACCCTTCCC TAGCCTACGC CTCCATTACA GATGACCGCA AGATTTATTT GCTCATTGCT GCCAACCAAG GCTGCACTCA CTGCAGTTGC TATCAGTTTA TCATGGGTAA AAGGAATGTG CAGTAGAGAA CTAACTAACT GCCCACCTAC CTCCACAATC CTATCAGGAC AAATCACCAT GGCTCACATT TCCTTACATT TGGCATGTAA GCCCCTCTTA CTGTCTGTCA TCTATCTCCT ACACAGTTCA CCTAAACTGT TCTCTCCTGA CCCAACCTTG ATTTTCATCC CAAATGCTTC CTTGCCATCT CTGGGATTCC TGTCTTCACC ATCACCAAAC TCCCCTCAAT CTTCCAGTTT CCTGTTCAAA CTTTTCTCCT ACCTCCTTGC TTTGTCATTA GCCCGACTGC CTCCCTAGGA CATCACTTCC CCTGCAGATC TCTCAAGATG ACAATATTTA TTCTCCACAC AGCACATACT TCAGGGTTGG AAGGCAGGGG CAATCTTCTC CTTTATAATG AGTGCCTCTT ATATATGTTT ATTCATCTGC CCTCTTGTAA AACACACACA CACACACACA CAAAGAAGAA ATAAAATAAC TCTGCTTCTT TGAAGCTTGT GACACTGAGA TAAACCATCT CACTGTCCTC ATTGTAGTGA CCTCTCAACT CCTCATGCAA GATTGGCTTT GGCACCTAGT TCCTGATCTT CCTTTCCCTG TAAGCACTTC TCATAGTCTT ACGGGACTTC ACCATCCATG GCACAACCAA TACCACAGCC CAGATCCTCA GCTCTCCAAT GACATTTTCC TCCACTAGAC TTGAGCTACC TCCTTCCCTA GGCACAGCCT CAACCTCGAC AACACCTAAG ACTGTACCGT CTCTAAAGTC ACATGTTCAA ACACTTCACT CTTTAACCAC TGTCTCCTAT TCTTGCAAGT GTATTGCTCA AGTATCTCAT TGCAATGCTT TTTACTTCTA CCTCATTGAA CCTCCAGGCC ATTAAACATT TCCTTATTTC TAACCATCAG GTTTCTCCTT ACTTGTTTGT TTGTTTATTT GTTTCTTTTT TTTTTTTTTT TTTGAGACAG GGTCTCACTC TGTTGCCCAG GCTGGAGTGC AGTGGTATGA TCTCGGCTCA CTGCAGCCTC CATCTCCCTG GTTCAAGTGA TTCTCATGTC TCAGCCTCCC GAGTAGCTGG GACTACAGGT GCATGCCACT ACGCCTGGCT AAGATTTTGT ATTTTTATTA GAGAAGGGGT TTTGCCATGT TGGCCAAGCT GGTCTCGAAC TCCTAACCTC AGGTGATCCA CCTGCCTCAG CCTCCCAAAG TGCTGAGATT ATAGGCATGA GCCACTATGC CCCACCTGGT TTCTCCTTAT TTATTTCAAG TCTATGCTGC ACTATTAAAA CTGCCTTGAC AAAAATTATA ATAGTGAGAA AATTATGACA GTGAAAGAGA TCTGAAATAA TCAACCCCCA TCTTGCCTTT ACCTTCCAGA CTGCCCTTAA TAATTCCTGA GCTTGGGCCA AGCTATCTTT GGCAGAAATT TAGTTTATAG TTTAAATGAT AATAGCCCTT CTCCAAAACT AAACTGCCTT TGTAAAACTA ATAAAAGACC ACCAATGAAA GGTTAGGAGG ATGAGAGGAG CCTGAATTCT GCTAAGGTGT AGATGTAAAC AATTACCAAC TGTTATTCCG GAGGTCACAA GATTTGCAAC ATCGCCAATT ACTCCTGCAG ATAACAGCAC TATCATAGAA TCTGATTGGC CTTTTGAGAT GTCTTTTCAG ATTCTTACAT TTCAACTGGT GGCTCTACCT GGACCCATCA ACAAGTCCTG TGGCTCCACC CAGAAGCAGA CTTAACATGC ACAAGGACCA TTTTCCACAC CGCTATGATT GCATCCCAAC CAATCAGCAG CAACCATTCC TCTGCCTGCC AAATTATCCT TGAAAAATCT TAGCCTTAGA ATTTTGGGGG AGGCTGATTT CAGTAATAAC AAAACCCCGG TCTCCCATTT GGCTGGCTCT GCATGAATTA AATTCTTTCT CTATTGCAGT TCCCATCTTG ATAAATCACC TTTATCTGGG CAGCAAACAA AAGGAACCCA TTGGACAGTT ACACTGTTGG CAGATATATC TTGCTTCCAA AATTGGATTT TTGTTTAATG AATTTATTCT GTTTTCTTGA TATTTACAAC TGTGAATGTT GTGTCTGAAT TCTCTTTATT TCTTGTTGAA AAGAACTATA TTGCTACAGC CAGTACATAC AGATGGATAG CTAATTACTC AACACGGGGG GATGTGACCA TCACCGCACT GTGCAAATGA ATGTTACCCA TTGTCCACTT TTCCCAAACT ACATAGTGTT ATATGGTATA TGACCCAATC AACGGTGGCA AAGCTCCAGA AATACCACAT AGACATCAGG GACACTTTAA ACTAATCAGC CTATAGTCCT TTTTCAGTAA TTTCCAAACC TGGTTGTGCA TCCAAATCAC TTGGTAACAT TAAAAAAACA AAAAAATATA CACGCAACAT TCGCTCCCAA TCCTACTGAA TCAGAATATT TTGGGTTGGT TCAGGAACAT TCAGGAGTTT TTCAGGGTCC AAGGTTTATA TAATTTGAGG TCTCTCTTTG AGAAAAGGAA CGTAAAAGCG TCTTGCTTTT ATAGATCTTA CAAAGATGTA TTACCATGTA AACACATTCC TAGGACCCAG GCCCTTGTAA TTTAAAGGTT TATCTAAGTA ATGGGCCCTG AAGCTTAATT TTCATTATCT TCAGGGCAAA TTACCTGTGG GTTAGGGTTT AGGAATATAT CTCTCTGTGT ATGTGTGTGC ACATTAGCAT GTACGCTTGT GTGGATTTTT TTTTTTTTTT TTTTTTTTTC TGAGACAGAG TCTCGCTCTG TCGCCAGGCT GGAGTGCAGT GGCGTGATCT CTGCTCACTG CAAACTCCGC CTCCCAGGCT CAAGCGATTC TTCTGCCTCA GCCTCTTGAG TAGCTGGGAC TATAGGCACG CACCACTATG CCCAGCTAAT TTTTGTATTT TTAGTAGAGT TGGGGTTTCG CCATGTTGGC CAGGATGGTC TTGATCTCTT GACCTCGTGA TCCACCCGCC TCCACCTCCC AAAGTGCTGG GATTACAGGC GTGAGTCACC ATGCCCAGCA CTTGTGTGGA TGTTTTAAGC TCCCAGGTGA GTGAATACAA AACTAGATCT TTCCCTTCTG TAGCATCTGT ACTGTTTACT CTATGCATCT CAATATTTTT TCTTTTAGTA TCTTTCCTTT TTCTCTCTTA TTACTTCCTC TTGTGCTATT TTTACACCTC CTTTTTTAAA AAATTTTTTC CCTTTTATTT CTATTGACCT TTAGCCCTCA CAATGATTCC TACAAGCCCC ATTTCTGTAA ATGGGGATTG AAATAATTGC TGGACTTTTG AGAGATAGAT ATATTAAATT GCAAACTGGC AGTAGTGGGG GCAGTTGATA CATAACTAGG TTTTAAAGTC TAGCCTTCTG AGACCACTCA TTCCATTTGT GAAAAGTGAT TCTACTTCTT ATTATGAGCC AAAATATGCA TTCATTCACC CATGCATTGA TTTATTCATT CAATAAATAT TTGTTGGATG TCCACTCTGT ATCAGGAATG TGCTAGGTTC TGGGAATACA GCAATGAACA AGGTAATTTT TCCCTACCCC TAAGGAACTT AGAGTTTAGT GGGGAAGACA GACATTAAAC AAACAATTGT GCAAGTAATA ATCTATAATT ATTTATTACA ATTAAAGGAA GGAAGAGACA TATGGATTAT GAGGGCATTA AAGAGGAGAC CTAGTGTAAG TAGCCAGTTC TCGTGAAGGG ACATGTATTA GTTGGAGTTC TCCAGAGAAA CAGAACCAAT GGTGTGTGTG TGTGTGTGTG CGTGTGTGCG TGTGTGTGTT GGGGTGTGGG GGTGTGGTAT TTTTTATAGA AATTGTCTCA CACAATTATG GAAGCTGAGA AGTCCCATGG CCTGCTGTCT ACGAGCTGAG AACCAGGAAA GCCAGTGGAA TACTTCAAAG TCCAAAGGCC CTGGAACCAA GAGTGCCAGT GTTGGAAGGC AGGAGAAGAT GGGTGTCCCA GCTTAAAAAG ACAGTGAATT CACTCTTTTT GCTCTACATA GGGCCTCAAT GGGTTGGATC ATGGCCACCC ACATTGGTGA AGGCAATCCT CTTAGTCTAC CAATTAAATA CTAATCTCTT TGGAAATACT CTCACAGACA CACTGAGAAA TAATGTTTTA TCAGGGTGAT AGAAATCTTC TGGAGTTAAA CAATGGTGAT AGCTGTACAA EPI-109 158

TCACATACAT TTTTAAAGGG TGCGTTTTAT GGAAAGTGAG TTTTATCTAA ATAAAATTTC TAAGAAAGAG ACTTAACACA GAGATAAACA TAAGCACATT TATTGTCAAC CTTTATAGTG TTATGTCAAA TAGGTCTGAC ATAAGCTTAA ATAAATATAT ACTTTAAAAA TTATAAAATA TTΓTAAGTTA TAATTTAAAA TTCTCAATAA AACTCAAACA CAAACCACAC TGGTATTTCA CACAGCTAAT TTCTAATGCA GTTTACATAA ATATTTACAA CACTTAAACA ATTTCAAAGA AAATAACACT GTATTCCATA CATAGCCTGA TCACAGTAGT TGTTCTCTCT TATTTCCCAG AGTTTTTCTG CCCCTTTAAA AGAACCTCTG CTGTTCTGAT CCTTATCACA TCTCTGTTTT GACTGTTGGC TTTGTTGTTG CCAGTGTTCA GCCAGAACTT CTCTGAAACT TTTTTTTCAA CACATGCTAA GTTAATGGAA GTGTAGGAGA GTTTTGATTC TCACACTCCT CAAGGCTAGA GCAGCTTTGG CAATTACTGA CTGAGAATTT TTCATTGCCA GTGATCAACT GAAAACTGGA GATTCCTTTG GAATTGTTAA ATCTGCTTAT AAATAAACAT AAATGCTTGC TCACACAGGC ATTCCTCTCT TCCAGAGCAC CCTAACATAC AGAAGAAAAC AAATAGGGAA TAACTATTAG ACATCTTCAT TCGTTAAAAA TCTACCAGAT GACTCTTTTA CATGGTGAGT TTCTATTGTG AATTTAAAAT CTTCCATAAT ATACAAGAAT TATGTTTACA TATCATATCT GACAAACATC TTTGTAGGAA TGCAAAGCAC ATCCATCTTT CTGTATTCTT TTCCAACAAA GACATTCATA AAATTATACC TTTGTGTGTT TGCATTTATG CTTTTATTAG TTCAAAACGT TTGGCCTCAT GGAAGTTTTT CATCGTGGAA ACCACATATT TCTGAAAAAA TATCTGACAA TATACAAACC TTCCATTCAG TTTTTACTCT CCAATTCTAC CATGTTTTCA AAAAACAACT GTAGTAAAAA CACTCAGAAC TTTATTCTGG TTAACATCAT GCCTTGCTAG GGGACAATAG TTTCCCTTTT TGAAATAAAT TTAAAACAGA TGTAACATAA TTTGTTAATA AACAATGAGG GGGTAATCTA GAATAAGTAA CTTTTACCAT ATCATAGTTG ACAGCATTTA CAAGTTTTTT AAGTCCCTAC CACACTTGTA TTGAATGAAG AAGTATGGAA GATTATAATA TATTCAATGC AAGTAAAAAT ATCACAATCC TTAAGAACTC TTTAAGAAGC ACTGAATCCC ATAGGGATGA AAGTGATTAA ATTGTGCATA GTAACCCTCG CACAGAGCAT TCAGTAGGAT TTGCACCATT AACAACCCTC CATGCATTTG CCTGTGGGCA TTCAACATCT GTCATTTTTT TAAGTTATAA TATTTTTAGT CATTTTTTTC CTCTAAACTC TGGATAATTA TTATTCATTC TTATGACAGC AACTGTGTAA TCAGCTGTCG AAACACTGTG AAGGGCAAAA GAAAGAAAGC CACAAAATAT TGTGTTTCTG TGCCAAGATT TTACAGCGAG CAAGGGAGAG TTAGAAAAGG AATTCTGAGA TTTCAGAGTC TTGGTCTCTT CACCTTTGCT TGGAAGAAAA TATCCTTTCC CTTCATTAGC CAACACTTTC TTGATCCTGA GAGTAGGAAA GGGAACACTG AGTCTTTTCA GTTGAAGGCC GTCCTTGCCT GCTGGACTTT GATCTATTGA AGTGGTGATG GGTGTTGCGG TTTCAGCCAT AAAGGCATCT GGCATAGTAG GCAAGAAGGG CCAGAGACCC GAGGAGAGTT ATCTGTCTCT GTTAACTTCA GTGTATCCCT CTAGTTCCCC AGATGCACCT GTTTCTGTAA ATATAAACAT GCATGTCATC AGAACACTTA ATATTCTGCA TACTGATCAT GACAACAAAA TGTACCTTCT AACACAGACA CTCTCACTAG GATAGACCAT GTAGGAACAT CGAATTCTAT TCAGTTAGGA CAGTGATGAT GTCTACATAT TATACCTCTG TCAAAACCTA CAGAATATAC AACACAGCAC AGAGTGAATT CTAATGTAGC CTGTGGACAT TAATGAATAA TAATGTATCA ATATTGGCCC ATCAGTTGTA ACACTAATAT AAGATGTTAA TAACAGGGGG AATTGAAGGG GTGGTGGGGA GATATGTTGG AACTCTTTGT GCTTTCTGCT CAATTTTTCT GTAAACTTAA AACCGCACAC ACAAAAAAAG TTATTTTAAT TTTTTAAAAA GTATTCAGAG GGACTTGACC TTTCCAAATT CTCTCAAAGC AGGTCGGAGT AGTTAAGAAC ACAAATTTTA GAACCAGACT GCCAGAGTTT GAATCCTGGC TACACCACTT ACTAGCTTTG AGATTTCAGA CAATTTACTT AACTTCTCTG TCTCATTTTC TTCATCTGTG TGATAAGAAA TAAAGTAACA GGCCAGGCCC AGTGGCTCAC GCCTGTAATC CCAGCACTTT GAGAGGCCAA GGCGGGTGGA TCAGGAGTTC AAGATCAGCC TGGCCAACAT GACGAAAAAA TACAAAATCT CTACTAAAAA TACAAAAATT AGCTGGGTGT GGTGGCAGGC ACCTGTAATC CCAGCTACTC AGGAGGCTGA GGCAGGAGAA TTGCTTGAAC GCAGGAGGTG GAGGTTGCAG TGAGCCAAGA TCATGCCACT GCACTCCAGT CTAGGCAACA GAATGAGACT CCATCTCAAA ATTAAAAAAA AAAAAAGTAA AAAGAAAAGA TAAGAAATAT AGTACCAGCC CCTATCTCAG AGTTCCTAGC TTAGAAAAAT TCCCAGAATA TAATAAGTGC AATGTAAGGG TCAGCTATCT TCATTATTAT TATCTATCAT AAATGAAATT ACACAATAAA GCTAGATCCG TTTCTTTCCT CTCCTTCTAC AAAAAATAAA GCAACTTTCC AGAACAATAC CCAGGTGATG ATTTCTCCCC TGCTCCCTCC CTAAGATATT GGCAAGTTTG GAGGGTTCAA GGAGAAACAG AGCATGTAGA GAAGATACCT CTCTCATAAC CATTTGTGAT TTACAAGTCT TACCTGATTC TTTTGAACTT AAAGGATGTA AGAAGGCTTT TGGTAGCTTC CATCTGATTC AAGGCTTTGG CAGCTGCTGT GGAATACATG AGAACACTAG GTAAAGCACT GTCTTCCAAC ATGAAGAGAG AAAAATATGT GGAATGTTCA ATGGCATGCT TTGTATAAGA ATGCAACTTA CCTGGCAGGA ACAAATTTCT TTGCTGCAAA AGAAAAGACA AACAACCATT AATTCAGACT AAATGACTTT TAAGGATATA TTAAATCCAG ATACAATATG ACTTAATTCA TCAAGTGTTG CAAACTCGAT GCTTCAGGGC CTCTGTAATA ATCAGAGCAC AAGCATGGCT CTGTGGCATC TAGGGTAAAA TGCAAAGTGC ACAGCCATCC AAAGGGCATA GCAGCTTCCT AATGCCAGCA AATAGCTACG GGGTCATCTT GCCCAATTCA GCTCCCAATT TTTCATGAGA AGTCCAAAGT CTTAATTTAA ATGTGAGATT TCCTATTTTG TAAACGTCAG AACTTAACTC AAAAATGTTT TAAGTACTCT TAAACATGTA AGCCAAACAA ACCATGAGTG TAGTCAGATG TGCTTCCATA TTCCTTATGA GAGACTCTCA AATTTAAGCC TGTACTCCAA ATAAATCTCC TTAGGAAGAA TTTTATCCAT TTTCCTTAGA GTGCTCATCA TGGCAGTTCC ATTGCACAAT TCCGGGAGGC ATCATATAAT TCAACATGAA TAGCACCCCC TGGAGTTGTA CAATATTAGG CACGACTAAC ATTTTTATTT CCTGAAACAC TTCCCACACT GAGTTGTACT ACTAACTCTT TTCTTAATAC TTCTGCTTAA TTATACTGCA TTTTATCCAG ATTCTAATTA TTGTTTAAAT CAGTAAGCAA GACCATGACT TATCAATGAG AAAGAAATGT ATTTTCAAAA ACATTTTTGA AGTACATTCA TAAACTTCCT CACCTTTCCG TAAGCATTTC CGAAGCCAGA GGAGAAATGG TGCTAATGTC AGGAGGGAGA GTCCAGCAGC AGAAAGTCCA GCTACCAAGG GAATGTTGGA CTCAGTGGGA GCTAAGGAAG TAAGAGACGA AGAAAGGTCA TGAGGAAGAA TTGATGTTAA AGTCTCTCCG TCCTGTCCCT TTGGCCTTTT TTCTGTACAT TCATTACTAG GAGCAGAAGA GCTATCTAGT TTAATACAAG AAGCAGAGAT GTGGCATTAC AGGCCTTTGA GATCTGCTCC AAGCCACCTT TGAAGCTATT TCCACCATTG GCAGGCAGAA CTCTAACTTG CCAAGCTCGT TCACAATACC ACACCACACC TTGGTTAATA AACACTGCAC TTGCTTGCTC TCTTGCTCTC ACTCCCTCTT GTTTTCCATT TCCCCTTTCT CCTCTCCTCT CTCTGTCTCC TTTTTCCAGT TGTCAGAATT CTACCCTTTC CATCAACATG CAACTTCTGT TTTTTCTCTA TCCCCATACA ACTTAATATT CACAACTTGT CAACCTGGGC GAACTTTCTG GTTTGGATAT AATGAATAGT TGATTACTGT AACAAGATAG CTCCCCCTTT TTCTTTTTAA TCACCAGACA ACCACCATCA ATCAATGCAT CACCTTCACA GGTAGGTAGC AGGCCAGACC AGTGTCCTGT GGCTCCACAT GTCCGAGCTG CAGAGCCATT GAGCGTCCAT CCTTCAGGAC AGGCGAACTT GCACACAGTG CCAAACACGG GCTCCCCACT GCAGCTCATG TTGATCTTTC CCGGAACTGC CAGGCTTGAA CATTTTACCA CTGCAAATGT TAGGTACACA GGCAGAGTTT CAGAAAAATC TACTGGAAAA CTTCCAAAAC TTGCTTAAAA GTCAACAATG AATGTAAAGT GTAAGCGCTA CTTAGTTTTC AGCATGTAGG AAATTAGGAC CAAACCCCTT TGGGGCAATC TAGGTTCAGA AACTTTATGA AGTATTTGAC CTGTACCCTA AAAAAGTCTG CACTCAATTC TACCTTGGCA GGAAGGAACC TCTTCTGTCC ATTGTCCCTG AGATGTGCAC TCAAGTTGAG TTGATCCATG TAATTCAAAT CCCTCCTCAC AGCTGAAGGC ACAAGAGGAC TTGTAGGTGA ATTCTCCAAT AGGGGAATGA GCACACCTCA CCAAACCCTT CGGGGGCTGG TGGACAGCAT CGCATCTCAC AGCTGGAACA CACGAGAGAG CACTTTAGAA GTTTGTTTGC ATCTCCAGCA ATACGTTTCC CAAGGTAACC AAGTTCCCAA GCTCTTCAAT AGTTCTTTTT ATCTTAAAAT AAAATAAAAA CAAAGACTGT ACCTTCACAT GTGGGCTTCT CGTTGTCCCA CTCCCCTGTG GGGCCACATT GGAGCCTTTT GGATCCCTTC AACACAAAAC CCTGCTCACA GGAGAACTCA CAGCTGGACC CATAACGGAA ACTGCCAGAA GCACTAGGAA GACAATTCAT GTAGCCTCGC TCGGGGTTGG ACAAGGCTGT GCACTGGAAA GCTGAGACAT CAAAATGATG GTCAGAAAAT ATTGCAGTGG AACTAGAGAG TACTTGGCGT TTGTTGAGTG AACCCAGTTC ATTCAAGCAA CACTTGGAGA ACTGAAGATT CTTTATAATT CCCTGGACAA ATGGGAAGAT GGCTGTGTTT TCTTTGAATT TCAGCCCCCT CACTGATCAT GGCACTAATT AAAAGACTAA TTAATCAGAA CATTAGTTCC TGAGCACTGT TCTTCTAACA CACAAAATAA ATTATGGTCC AAGGAAAGAT TTCACGCAGT CTGAGGACAA CATATGGGTC ATGGATGTTT ATAGATGGTG CCAAAAAGAA AGAAAAGAAA GCACCCCTAT AAAATTTGTC TGTTTTGCAG TTTGGTTTTT GTGTTATGTT EPI-109 159

TTGCTACTGG AAATCATTCT GTGCTGGCTT TGGCTAGGAC AAGGCCAGTG CCTGATAGTA AAAACTGCTT GTTTTCAATA TCCTTGCTCT CACTTTAAAG TGAATTAAAA TTTACTGCTT ATATATGCAT CAATACTATC TCTGTAGCTG ACACCATGCT TGAAACAGTC TCATCACTGC TAATTATGAG CCATTTCAGA AGACAGGTGT GATGAGAGTT TTACATTCAA ATCATGTTCT CATTATTCTG CTTTCCGAAT TTTCTAATAT GATTCCTTTA GATTAAGAAT TCTGTCTATT CCATGCTAAT GTCTACAAAG TTTTATCAGC ACATCACAGT TAAAAAAAAA CAGCAAAGAA TTCATTCTTA ACACATATGA TCCTTTCCCT GGCCAAACAT TAGTTCTTTT AAATGAATCT CAAAGATACG AGGGTTGCTC ATCAAATCTG ATTTCTATAG TTAAAGTGGG TATTGGTTTT TTTTTTCACT GTCCAAGTTT GAAGATGGTT GTTCTTTAAG AAAGTATAAA TCGAAGGATC TCAAGCTTAC CTTCACAAAC TGGGATTTGC TGTGTCCACT GCCCTTGAGT GGTGCATTCA ACCTGGGCTG GTCCCTGCAA CATGAAGCCT TCCTCACAGG TGAAGTTGCA GGATGATTTG AAGGTGAACT CTCCAGCAGG GGAATGGCTG CACCTCACAG AGCCATTCTG AGGCTGGCGG ACGGCCCTGC ATGTCACAGC TGTAACAAAT ATACGCATTG ATATTAGCAC GGCCTAGAAT TAGCTTGCCC ATTTCCAGTA TGGGTTGAGA GAAAGAATGT TCACAGTAAG TCTCCATGTG GAACAACTCT ACCTTTACAC GTTGGCTTCT CGTTGTCCCA ATTCCCAGAT GAGGTACACT GAAGGCTCTG GGCTCCCATT AGTTCAAATC CTTCTTCACA GTCAAATGTA CAGGTTGTGT TCCATGGGAA GCTTCCAGGG TTTTGGAAAC ATTCCACGAA CCCATTGGCT GGATTTGTCA CAGCATCACA CTCAACCACT GAGGATTTTA AAGAGCACCA TGAATTTTAC AGAAGAATGA TCTTTTCACT TCCTATTGAG CTGGGTGCCT AACAGAGTGA GGAAGCTGCC TTCAAAGGGT AGATCCCAAA GTCCTATGTC AATTCTTAGG GACATGCACA GCCAGAATAA AAGCTTTTAT TCTTTTTCAT GGATATTCTA TCTTTTCTGA TTTCCACTTT GCCTATGCTG AGTGGTCTCT AATCTATGTT ATCATTTACG TGAGGTAAAA ATTTAAAAAA AATAGATTCC AGATTAGGAG TTATGACTAG TACTGACATA CGTAGGCTAT TCATTTATTT TAGCCCATCA GAGCCTGAAG AACTGATTTT TCTTTTTTTG GCCTCTGGTT CAGAAAGATA AAATTAAGAG AGAAAAAGAG ATACTAAGAC TGCTTGACTA TCATGGTCTT AAGTTAGTCC CATGGCTTGG AAAAGTTAAA CAGGGAAACA AGATGAGAAA TCCATTGAGA TTTCTAGAGC TTTATTGTTT TATGGTCTCC CTTACAAATC ACCAGAGCCT CAGAAACACC CATTTCAAGC ATAGAATAAA AAAACCTCTC TCAACCCAAG CAGGTACTGG GTTGGCAATA TACATTGGCT GAGAGAACAA ATTGTATTAA AAACAAAAAC AAAAAAAAAA CTTTCCCTGA AGTTTTGAAA ATGTAAGTTG AATCAAAAAA CAGAAGCAAT GAGGGATGAG TTACAGAACG TTCTGTGCAT TCTCAGAGGG ATTTACCATT GCAGGCTGGA ATAGGAGCAC TCCATTCTCC AGAGGACATA CACTGCATGG TCTCCATGCT GCTTGGCAGG TAACCCCTAT CACAGCTGAT AGAGCAGGAA GAATTGTAGC TGAAGTTTCC CAGTGGGTGA CTGCAAACCA GGCTTCCATG CTCAGGGGAT TCCAGGGCTG TACAGTTCAC AACTGAAAAA GAAACCCAAA TCAGTTCTGC TCATCTCTCA CCTTTAACAG ATAAGAACAC TGGAAACTAG AACTACAGTT TGGTTTTTTT TTTTTTTAGT TTAAAAATTT ATAAAATTTC TAATGGAATT TGTAAAATTG ACTGTAATTC TACCCCTTTT CTTTTATTCA AGAAAATGCT GATCCATAAC AACAACAACA AAAAAGCAGT GATGACAACC ATAAAAAAGA AATATTGAGT GATATGGGGA GAGTAGTGTA ATTGTGTTTA CCTCAAAACT GTTCAAATTA TATGAACAAA CACAGCAAAC TTAGGTACCA CAACAAATTT CTTGTTACTT TTCTCACAAC TGCTAAAAAT ACTACAGTAA GCTTCCAACC AGGATGAGAA CCATTCACAA AGCTATATTT CAAATTTAAG TACTAGAATA CATTACAAAT TTTAAAACCC TAATGCTCCA CTGTCTACTA TAGTAGCCAC TATCTGTGTG GCTACTCAAA TTTAAACTTG AATTCGTTGA AATCAAATAA CATTTAAAAT TCAGTTCCTC AGTGTCACCA GCCACATTTC AAGTACTCAA TAACCACATG TGGCTCATAG GTACACACTG GAAAACACAG CTATGGAACA TTTCCATTAT CACAAAAGCT CTACTGCACA ACGCTGTGCT AAGGAATCTT GGAGAGAAGC TCATCTAACT CTCTTAATGT ACAAATTTAG GAACTGAGAC CTCATTTCAT TCAAGTGACT TGCTCCATGC TACACGGCTA GTCATTACAG AGCCAGAGGC CAGAGCATGA ACCAAGATAC CCTGGACTCT GTAACTCACT CATTTCTACT GCAACGTCTT GTTACCACCT AGATGAGGTG AGTACATGTT CCTCGCAGGG ACACAGAATT ACAGTTTATT GAATGTGTCC TGTGTGCCAG GCACCATGTA ACCATGAGCC TATGAAGTTC ACACTATTAT TATCCTCATT TTACAATGAG AAAACTGACA TAGAGAGTTA AACTATCTTG TCAAGGTGCC AAAATAAATA ACTGGTGAAT CTAGGACTCA AACCCAGCAG GGTCTGACTT CATAGTCTCA GCTCACGATC ACCATATGAC ACCATCTGCA CCAGGGAAGG GAAGGCATGC AGACCTGACT CTAATGCCAG CTAGGACGTG AGATGGTGCT ACCATCTCAA GTGAAGAAAG AGGCAAGAAC CAGACTTACT TTGCTCACAC TTGAGTCCAC TGAAGCCAGG GTCACACTTG CAAGTGTAAT TATTGATGGT CTCTACACAT TCACCGTGGC CACTGCAGGA TGTATTGGTA CAGGCAGCTA CGGAAAATAC AAAGCATGAT GAGGAGGACT ATTACTGTGC TTATACTGAG TGCCTTTGAT TTTAGAATCA ACAGTGTGCA ACAGAGACAT CAGCAGTCCT ACAGAGTGCC ATAGACTTTA ACTGAAGTGT TTTACAAAGT TCCAAATCTG AGTTTCAGGC CCACCTATCC TAAACCTTGA TGCTAATGTA TAGCTGTGGC TGGCACCTAC CGTAGAAAAT TTACTTCTTC ACAAACTCTG AAGACAGTTC CCCTACCACA AATAAACAAG TAATTAAAAT ATGTATTGTG TGTGTGCATT TTTATATGTA AAGAACTACA TATTTGCCTA CAGTATTTAT ATATATTTTA TATATATACA TACACACATA TATGTGTGTA TATGTGTGTA TGTATATATA TAAAATGTAT ATAAATGCTG TAGGCTATAT ATATATACAC ACACACATAT ATGTGTGTGT GTATATATGT GTGTGTGTGT ATATATATAC ATATCCACAT ATTCTTGCCC ACATTCACAC AAAACAGCAA AAGAGAGAAA CTTTAGCAGT TAAACAGAAT CTTTTGGAAC ATAAAATGAC CACAATAGAG AGCAGTTTTT GCATGCTGTA AATTTGCCAA GATGCCCACA CACTGAAACT ACCTCCCACT GCTGCCGCAA ACTCCCTACC TGTGTAGCAT AGGGCAAGCT TCTTCTTGCT GCACCTCTCA TCATTCCACA TGCCCACATC TTTTTCTCTC TTGATGTAGA TCTCCACGCA GTCCTCATCT TTTTGCCTAT TGTTGGGTTC ACCTGGAGCC CAGTTCTTGG CTTCTTCTGT CAGAGGTTTC TGGGTTCCTA CCCAGACCCA CACATTGTTG ACTTTTCTGA TTCCAATCCA GTAATAACTT GGTGAATAGC TCAATATGGA GTTTAGGTAC TCAATCTCTT CTTTGTTTTG AATTGCAACC AGGTGTGTGT ACCTTTGCTG ACAATAAGCA CTGGCCTCAT CATAAGTCAT AGCTTCCGTG GAGGTGTTGT AAGACCAGGC TCCACTCTCT TTAATGAGAA GCACTAGTGG GAGAAAAAGA AAAGAAATGG TAGAGTTTGG TACTGTTGTG GTTTAACTCT GACAACTGTG CTTTTTATTG TCTTATTTTT GGCAATGTTT GTGACATGGC CCAGACTTTT CTCATCTTTT CAAAAGTAAG AAGTACGTAT GAAGAAACAG CGACTTATTG TTTATCTCTT TTGTGACTGC CACCCACTAG GTACCTTATC CACACTCACT CACAACATTA TAGTATACCC ATTTTGTAGT AGAATAATAA TCAGAATAAC TAAGCTTTAT TGAGCACTTA GTATGCACCA AGAAGCACTG TATGAGGTAC TTTCCATGAA CCATGCTATT GAATCCTCAC AATGCATCTG GGAAATAGGT CATTATGATC CACACTTTAC ACTTAAGGAA AGGGAGACAC CAAGAGGTAA AGTAAATGAC CCCAAGCCCA GGGAAGAACA CATTGCAGGT AGAGGTCAAG GATGCTGCCA GATATCCTGT GCAGGACAGC CCCAGACAAG CAAGGATATT TCAGTCTGAA ATATCTATAG TGCGAGAATG AGAAATCTTG GTCTAATGGC ACTGACTTAC CCAAAGTGAG AGCTGAGAGA AACTGTGAAG CAATCATGAC TTCAAGAGTT CTTTTCACCC AAAGGTTTAG GCTTGAAATA CTTTCCTGGG GAGATAAAAC ACAAAATGAA TTAAAGAAGG AAATCGTGGG TAGCTAGTTA CATTATTCTA CCATGATGTT TAAGGCAGCA TCCTAAGATT TTGGGCAAAG GACACTAGTG CAATAATCTT TATTTCAGAG TTTAATCAAA TAAATAAACA AATTTTAAGA CTTTCATTAT TTAGGTCAAA GAGAAAAGAC AGGTTTTAGC TACAATACAA TAAGAGCTTG TACAGATGTG GTTTTTATTA GAAGGCCTTT TGCATATCTG TGTTTCATGG CCCGAGGCTG CCCTTATAAA GCGTTCTGCA CTTACCGTTT TGGGAAGCAG TTGTTCAAAC ACAGGATCTC TCAGGTGGGT ATCACTGCTG CCTCTGTCTC AGGTCAGTAT AGGAGTTTTG ATGTGAAGTC AGCCAAGAAC AGCTGAACAC TACTTCGGCT GAGGCCCTTT TATAGGAGGG ATTGCTTCCT GTGAATAATA GGAGGATATT GTCCACATCC AGTAAAGAGG AAATCCCCAA TGGCATCCAA AAACTTTCCC GGGAATATCC ACGATGCTTA AAATTACAAT GATGTCAGAA ACTCTGTCTC TTGAAGCTAC TTCACCTTTG TCCATGCCTT TATATCGTAT ATGCAATTTT ATTAATATGA CAAAAATGCA TGATTTTTAA TTATAATAAC ATAAAGTCTA TGTCTTTAAA AAGTTGTAAA ACTTTGCTTG TTAGTAGTGT CTCTCATGTA GTTGTGGTAG TAATTAGAAT TTCAGAAACA GAAGGAAACC AAGAATAGGT TTGTCATCCA TAGTCTACTA CCTTCAATTT CTCATTCATA GCTGTGGATA ACCAATCACT ACTCATTTTT TCTTCCTTTT TCACCTGCCA ATTCAACATA TTTAACATGC ACTGTCTCAC AGAGGAATGA CTCACAAGGT AGATATTAAT CTTCAGATTT TGCACGGCAG TTATGCCTAA ATTAAAATAT TATCTAAAAA TAATATCTAA CACTCAAATG GTTAAAATAA TGCCTTATTT TAAAAAAAGA AAAATGGGAA ATAGATATTT EPI-109 160

ACATCTGGGA AAGTTTCATG GTTTGTTCAG TGAAAAAAAT AAAAAGGAGG CCAGGCACAG TGGCTCACGC CTGTAATCCC ACCACTTTGG GAGGCCGAGG CAGGCGGATC ACCTGAGGCC GGGAGTTCAA GACCAGCCTG ACCAACATGG AGAAACGCCA TCTCTACTAA AAATACAAAA TTAGCTGGGC ATGGTGGCGC ATGCCTGTAA TCCCAGCTAC TCGGGAGGCT GAGGCAGGAG AATCGCTTGA ACCCGGGAAG TGGAGGTTGC AGTGAGCCAA GATCACGCCA GTGCACTCCA GCCTGGGAAA CGAGTGAAAC TCTGTCTTAA AAAAAAAAAA AAAAAAAGAA AAGAAAAGAA AAAAAATAAA ACGGAAAACT ATATATATAT ATTTAATTGG TCAAAATTTT GTTTAAAATT TTTGAAATGT TAATGTGCAA AGAATAAAAA TTCTTCCACA ATGTTAACAG TGACTAACTC TGGATGGCAG GATTTGGGAT AATTTTTATA TCCTTCATTA TTATTTTCAG GATTTTAAAG TTTTTTTCAA TTTCCCTTTT TTTCACCTTT ATAGTAACAA GAATACAGTT TAAAGAAACT TGTCTCTAGG CCAGGCATGA TGGCTCATGC CTGTAATCCC AGCACTTTGG GAGGCTGAGG TGGGTGGATC ACCTGAGGTC AGGAGTTCCA GACCAGCGTG GCCAATATGG TGAAACCCTG TCTCTACTAA AAATACAAAA ATTAGCCGGG GTGTAGTGGC GCATGCCTGT AATCCCAGCT ACTGGGGAGC CTGATGCAAG AGAATCGCTT GAACCCAGGA GGCAGAGGTT GCAGTGAGCT GAAATCACAC CATTGCACTC CAGCCTGGGC GACAGAGCAA GACTCCATCT CAAAAAAAAA GAAAAAAAGA AAAAGAAAAG AAAAGAAATT TGTTTCCAAA TGCAACAGAA GGAGATGTAT GTGGTATCCT ATATTCCTGC TCTTCATTTT GACATTTCTT CTGGGTGATT GTATACATTC CCCATCTCTG CATCTTACCC TATCTAAATG ATGGTAACAG TAAATGGGGA TCATTTTAAT TTCCATATTC TGTAGGTTTT CAGAGCTCAA GTCAAGCTAA TATTCTATAT CTACAGCCTT TCAAAATAGG AGGTCTATCT AAAAATGTAC TGTCAGCAGA CCTGAACGAG TAGTGGTAAA AGCCTCGTTT TTCTCTTTAC TTGTTAGCAC TGGTCTTTCT GTGTTCATAA AGATGTCAAG ACCCAAAAAA AAAACAAGAA AAGAGAAGAA AAATTCCAAA AAAGACAACT GATTAGAAAA AAATAACTTA ATTAACGAAT TTAATTCAAC CCCTATCAAA AAGCATAGAA TTTATTCCCT CCACCTTACC ACTCTCTTAC ATGATCCAGA TACTGACATT ATTCCAATTC TTTATCCCAC TTTACTTAGC TCAATGTGGT TGTTGCTTCA ATAAATTCAG AAGAGTAATC ACTCATATAG TGTTTATTTA GATTTTAGGG CAGAATGTCA AGTTGGGTTA ATACATTATC TGTATGTATT TTATTTTTAA TAAAGTATGA ATACATAATC TGCTATTTTT AAAAAGCATG GTCAAATGTA TAGAGTAGCC AAATCTTAAA AAACAATTTA TCTTCGATAT CAATAAAGTA CCTAATAATT ATATTGCTAA TAGAAATTAG TCGTTAACAT CCCTAGATAA CTAACTTTAT TATTGCGAAT TTTTCATAAC TAAGTTTATA GTTTATCTCT TCCCCTTTTT AAAATTAGTT CAAAGATATC TAAAAATAGC CCCAGTGGTG ATGAAGTTTC TATTTTACTT ACATATATAT GTCCTGGACC CCCAATTATA ATCTCTAACA TTTATTGAGT GCTTACTATG TGCCAGGCCA TATTCTGAGC ATTTTGTATG TTCACCTATT GATTATTCAA TCCGTACAAC AGCCTATGAA ATAGGTACTC CTATTATCCC CATTTTACAG ATGAGGAAAT TGAGAATCTG GGGATTTTAT CTCATTCAAA AGCACAGAGC TAAGGGTTGA AACCAGGCAG TTGATATCCA GAGCCCACTC CCTTACCTGC TACTCCAAAC CATGATTTCT TTTGTTGTTA TGCCCCGAGA TTCCTTGTTC TACCCAAGTT TCCTGTACTC TTCTTGCCCT CTTCTTCCTG AGACATCCTT GACCATCACA GCTCTCCACT GAGATAACTG TGTCCTGGGT TCTGAGACAT GGGGGCTGGA AGGGACCCCA GGGACAGTGA GCAGTAGGGA GAGGATGCAG TGAGAACAGA CCCTGGATCC CCGGTGCATA GGCAGGGAGA AAGTGGACAA AGGAAAAAAC AAGCAAGGCA GGTGGAGCCA TGCCTAGGTA AAGTTGATCC CTAAGCCACA GTTCCCAGAA GTTCCTGATT CAAAAGCAAA TTTTCTCTAA GGTCAAAGGG CAAACTGATT ATTCTAAATT CTAAACTGAT TATTTCTAAA TTGAGAAAGC TTCAGGGAGA GATCCCAATA TTCGAAGGAT AAGAGAAATG AGGAGTGGAA GAGATAGGTG AGTAACAGTA ACTTAAATGT AGACTATATA TAATATATAA TATATGTAGA GTATATATAT ATAATTACAA TATATTATAT ATGTGGAATA TATATATTAT TTATATATAT TTATATATTT TATATATATA GATATTTTTA TATTTTATAT ATAAATATAG ATATTTTTAT ATTTTATATA TAAATATAGA TATTTTTATA TATATTATAT ATAAATATAT GTAAAATACT GTGAAAGAAG AATAGAATCT TGAGACCTCA AATTCACTAT GCCAAAGGGA AAGTTAAGCT TGGGAAATGA GTCATGCAAA AACTGCCTTC CTTTTGTTCC CAAATACCTG TAATTTCACA TGCTTACTTT ATCTTATATA AAATGTAGAT GTACTGAGCA TGAGATCCAT GCATAATTTC CCTCTAGTCC CTTCTTTTTA CATGTAAAGT GTAGACTCAC TGAGTGTTAC AGAGCCTTGC CACAATGTAA ACACTTGTCT CATTGCCAAC CCATCTTTCG TTTATTTTCT TCCCCTCCTG CTTGCTCTTT CCCCTCTAAA GATGGAAGTT CCCAAAACTC TCTTTGGAAA AAGCGCAGGT CACAGATCCT ACAGTGATTT GTGTTTCTTT TACCTGGGAC AAAATAAACC TCTAATCTGT TGAGATATGC TTCAGTTACT TTTTGGTTTA CAATATGTAC ATGTATGTAT ATAATTTATA TGTATATAAT ATATGTACTT GTTTTAACCA GAGGTATGTT ATTCAAAATC CATTCATCCT TACAATTACC TGCATTCTCC CACAGTATTT TCTGTGTCCC TGCCCCCGAG GTTGTCACTG CAAATCAGGT ACATGGATAC TGGGAGCTGA TGGGCTCCCC TCTGGCTACC TGGGCTGCTG AAGGGGCCAT AGACAGACCC AGCTTTCCTC TCGTGGAGAG GCCCTGGGCC AGCGCTGCGT GGGAGTGGGA TTACAACCAG ACTATAGCTT CTTCACCTGC TTTTTCCTAT CAGGATTTCA TAAGAGGCAA TTGCTTGTTT TTTGAGGGTG GGGGCAAATC AGGGGGAGTT GAAGAGGAAA TTGGGTAAGA TTTGAATAGT TGGGCATGTT GAATATTATG AATATCATCT CCCTCTTCAA ATAATCCAAA ATATACCCCC AAGAAACAGG CTGATTAGAG GTGCTTCAAG GCTCCACTGA ATCTCCCAAG CTCTGAAGAT GTAGCTAGCT GTTACCGGAT TGCCGGTTTT CAAGCCTCGC CTCACATGGA CCCTCTTGGC AGTTTCTCGC ATGGGGGAAG CATCCGCTAC ATAGATGGGA ATGAAAAGAG GAAAGAAGAC GGTGCAAACT CAGGCACACC CCGGTGTCTG CCACCAGTGC TATTTAATCT CTGAGGTGTC ACCCTTCCTG GCTTTATTGT CTCTTCCTGG AAGTCTCTTG TCCTCTCCTC CACACCCTTT AATCAGGCAT CAAAGACTTT AACCAGTTTT GCTGTGTGCC CAGGCCCACT CATTCTCACT TTTATGGCAA AGGGAGTGGG AGACAGAGAG ATAGCCAGAA AGAAGAGATT GGGGACCCCA AGACAAATGT TAGAATTTTA ACCAAGGCCA CCCTGTGGAC AGGAGATTAT TGGGTTTAGT GGAAAGCAGC ACTGGCCACA ACCACACGTG GCAAAAGCAT CTATCGAGGA GTGAAGTTAT ATTTGGTGAA TGTGACCGGG AAGCAGGGGC AGTGGTGTCC TCCTGCCTTC CTGAGGCACT CTGTTCCCTT ACCTCTGCGA AGGCTTATTT TACCCCTGAG TGCTTAGTTT TGAAAGCCTT AGTTCCCTCT CTCCCATAAA AAAGCTCTAC TCTGCTAACA TCTAAGTTAC CTTTGCAGAG TCTTAGGTAG AGGGAGGAAA TCCCAATAAA GATTCCACCC TATCTGCAAA ATACAAACAT GGTATTTCTT GCATTCCCAA AATTGTGAAA GAAAATGTGT ATCACCACAG TAGAGAATGG CATTTTTTGT TTGATCAAAA CCTAAATATA TTTGATGAAA ATGTGTCTGG TTCTAAGTTT ATTTCCCAGA AAGCCATGTT TACTCACTTG GAATTTATAG ACATCTTATA ATATCTGAGT CGAGTAGGAG CTCCGGGCTC TACCTCACTC TTTTCTCCCA CACCCAGGGG GAAGTGTAGG GTTCTCAGAC TTTAGAATAA AGAGGAATCA CCTGGACAAC TCACCTAAAA TGCACATCTT CAGGTCTCAT ACTCAGAGGC TCTGACTCAA CAGGTCTGGG TGGCGCCCAA GAATTTGGGC TTTAAATGAG TATCTCAGAT GATTCTAATA CAGAATGTGT AAGATGACCA GATCCTATCA CACTTAGATG TATTGGCCTA GGGCCACCTA ACTTGGAGAA AATGTTAGTA AGACCCCGTG GTTGGTGCTC AGCTATAGGT ACCAGAATTT TGATCAAAAT TTACTATCAT TGTGACACTT CTCTTCGGAA CTGGAAGGCC AGAACCCCAC TTGTAAAGTG CTGGGAAAAT ACAAGGAAAA TTTAGGGTGA GTAGCATTTT GAATTCTTAC ACATGGAAAG TAAATGTATA AGAATTCTTA CCAATAAAAA AAAAGCAAGA GAGAATAGCT GCTAAAGAAT TAACACAAAT ATGTATATAT TAGTTATTCT CTTTTCTCCT CTGATTCCAG AGGACTTTGT AATTCCACTA ATTCTTCTTG AGCTTCCAGG ATGATCTGAG ACTTGAATTT TTCATGTGCT TTTTGCTTCC TATTTGGCAG CATCTTATCT TGAAGTTTCC GCTTTCTGCT TGGGGACCTA AAAACTAACT AATGGGAATT TCTTCAAAAT GAGCAAACTC TGGTGAATTC CCAAAGCGGA AGAAACAAGT GAGGATCGGG CTGGTTAATT AAGAGAACTT TTCCTGAATG TAGCCAGACT GTTTGCCGAC TGTTGTTAAC ATGAGGGAAG AAATACCCCT GGATTTTAGA AGAGCCCCTT GTTTGTTTTC CTTGGCCATT TGTGCTGCTT GTTTTGTAAG TCAGAAATTT CCTGAAGGAC TATTATTAGC TTTGTTCTCA CGTCAGAAAA CTTCTGCTCT GGCCACTTTT AAACATATAA CTTGGATTTT ACTGTATTAG AAAATGTAAC AATTACAGAC AGCACTAAAA GGACACCAAA GGGCAAAGAA AATGGGTAAC TTTTTTTTCT TCCCCAAATC TAAAATAGGT GATTTTGGAG AAGTAGGAGA AAAACCTGGA TTTTCTAGAT CTCTTTAGAG CTCAACAACT GATATAGTTA ATTATGTAAG TCTTTGATAT TTGGAAATGA TTGGATTAAC CGGATAACAA TGAATATTTA AATACAGTGA TTTGGCCAGG AGCAGTGGCT CATGCCTGTA ATCCCAGCAT TTGGGGAGGC TGAGGCGGGT GGATCACCTA AGGCCGGGAG TTCCAGACCA GCCTGGCCAA CATGGTGAAA CCCCATCTCT ACTAAAAATA CAAAATTAGC CAGGCGTGGT EPI-109 161

GGTGCAAGAC TGTAATCCCA GCAACTCGGG AGGCTGAGGC AGGAGAATTG CTTGAACCCG GGAGGCAGAG GTTGCAGTGA GCCAAGATCA CGCCATTGCA CTCCAGCCTG GGCAACAAGA GCGAAATTCC ATCTCAATAA ATAAATAAAT AAATACAGTG ATTTAACACA AGAGATTTCT ATTTCACACT AATGAGCTCT GTCACTGGGG CAAGCTTCTT TGCCTCATTA AGTCTCAGAT TTCCCGAGAG CTTATTTATT TATACCAAGA GTGCTTTACT ACCGTCTCTG CTAGCTGTGA CATAATATGA CAAAAGGTAT AAATATGGGA AAAGGCACTA ATTTATATCA AAGCGTTCTT CGTTTTTCCT TGCTGTGAAG TTTTTAGCTA ATAATTCATA AGAATATACC ATATTTAGAG TGTTTACTAT GCATGGGCCT GGCACTTCAC ATACATTGCT TCTTACAAAT TTTACAAAGT GAAAGGTAGA TATTAATCTC ATTTTATGGA GGACAAGATA GAGATCTGGA GAGGTTACAT AACTTGCCAG TGTTTTTTCA GTTAATAAAT GGTAGGGTGG AGATTCAATC TGTGTTACTC TAAAGTCCGT GTCCTTTTTA TTGGCTCCAT GCCTACTCAG ATTTAAATCT CAGCAGGGAA GTAAACCTTA GTTTTTACAT GAGAAAATGT TACAGCAGCC TTCTCGGCTT CCTTTACCCC CATCCCAGTT TCACGAGCTT AGTGCCTTAG ATCGGGTTCC TTTAGAAGCA GACCTCGAAA TAAGGATGTG GGTGCCAGTC ATTTATTGAA AAGATGATCC CAAGAAAGCC TAGTAGGAGA GTGAGGAAGT GAGATGGGGA AAGGAAGAAA CTCCACAAGA AGTGTGTTAA TAAGCAGGTT ACCGCTGTGG GCAGCCATGG GGCTCAGCTG CACTAACAAA CTCTGTCTAG TACAGAAAAC CTCAGGGTCT CCCCAAGGAG GGGCAAGAAG TCTGCCTAGG GTATATATCC GCCAACTCAG TCACTGGCTG AGAGCTGATC CTGGGAGGGC ATGGTTAATT CCTCTGCACT TTCAAGTGGA TTCCTGTGGT CAGAAAAAGC CCTCTACAAT GAATTCCAGA TGCTTGTATT TAAATCTGAC ATGATCTGAA TGCTGTGTTG GGACAGGGTG GGCGTTATTA GTTTTCTGTC ATTACTGTAA CAGATTACTA CAAACCTGAT GGCTGCAAAC AACACATATT TATTATGTCA TAGTTTGTGT GGGTCAGAAG TACAGGTTAG CTCAACTAGT TTCTCTGCTC TAGGTTTCAC ATTGCCAATA TCAAGGTGTC ATCCAGTTGG GCTCTTCTTG GGAGGCTTGG GGATGAATCC ACTTTCAAGC TCATTCAGAT TGTTGGCAGA ATCCAGTTCC TTGTGGTTGC AGGACCAAGG TCCCTGTTGC CTTGCTGGCT GTTGGCCAGG AGTCATTCTT AGCTTCTAGA GACTACCTGT ACTCTCTGAC TCGTGTCTCC ACTTCACCTT TCAAACCAGC AGCGGCTAGT CGAGTCCCTC TCTTCAAATG TCTCCAACTG TGCCTTCACC TCATTTCTCC TCTGTGTACC ATGTCTGCCT CTACTGCTTG TAAGGGCTCA TGGGATTACA TTGGATTTAT TCAATCCAGG ATAATCTCCA TATTTTAAGG CTAGCTGACT AGTGATCTTA ATTCCATCTA CAAAGTCCCT TCCAATAGTA CTGTATTAGT CCATTTTCAT GCTACTGATA AAGACATACC CAAGACTGGG CAATTCACAA AAGAAAGAGG TTTAATTAGA TTTACAGTTC CACATGGCTG GGGAAGCCTC ACAATCATGG CAGAAGTCAA GGAAGAGCAA GTCATGTCTT ACATAGATGG CAGCAGGCAA AGAGAGAGAG CTTGTGCAGG GAACTCCTCT TTTTAAAACC ATCAGATCTC ATAATACTTA TTCACTATCA CAAGAACAGC ATGGGAAAGT CTTGCCCCCA TGATTCAATT ACTCCCACCA GGTCCCTCCC ACAACATGCA GGAATTCAAG ATGAGATTTG TGTGGGGACA CAGCCAAACC ATATCAAGTA CCTAGATTCA TGTTTGATTA AACAACCAGG GAGCAGAAAT CTTCAGGAGT GGGGGGCATC TTTAGAATTC TGCCCACCAA GGCTGGGCGC GGTGGCTCAC ACCTGTAATC CCAGCACTTT GGGAGGCCAA GGTGGGTGGA TCATGAGGTC AAGAGATCGA GACCACCCTG GCCATGGTGA AACCCCATTT CTACTAAAAA TACAAAAATT AGCCAGGTAT GGTGGTGGGC ACCTGTAGTC CCAGCTACTC AGGAGGCTGA GGTAGGAGAA TCACTTGAAC CCAGGAAGCG GAGGTTGCAG TGAGCCAAGA TTGCGCCGCT GCACTCCAGC CTGGGAGACA GAGCAAGACT GTCTCAAAAA AAAAGAATTC TGCCCATCAT AGTAGGCTGT CCTACAGAGA CATAACCCAG GAATTAGGTG AATGGCTAAC CTAAATTAGC ACTGTGATGT GTTTTCTGAC TTGGTCCTTA TAGCTCCTCT GCTTAGATGT GGAACTAATC CATGAATGCA AGGGTTTGTC TAGAGTTTTA AGTGGGAGTT AAATATCCAA AGTACAGGAG ATATTATGGG TGCCTCATCC ATGTCCCCTT GGCATTTATC TTTCTTGGAT AACCCAACTC TATTAGTTTT TATATCTCAC TTGTTCCTAT ACTCTGTGAA CTGATGTCCC ATAAATAGAC ATTTCATTTT GCCAGTCTTC TTGAACAATA ATTACGATTA TTAATCTAGC AGTTATCATT AATTGGCCAC TTCACATTAG ACACAGCACT TAGGACTTAA GAATACCATG TCATTTGATC ATCATAATAT GGTCAGGAAT TAAGTATTGC TATCCAAATT TTACAAAGAA GGCACTGAGG GTTAGAGTTT AAATAACTTG CTTAAGATGT CATAGCCTGT AAGTGACAAA ACTAGGACTC AAATACAGGT CCATCTGACT CCAAAGTCTA TGTTCTTGGC TACCACACTG CCTCTCCTAC AAGTGACCTG TGGTTTTACT ACTATATTCA CACTCTACTA ACTTTACCAT CTCCCATGAG TCTGTCTAGA GGAGGGCACA CACAGCACAG AAAACACATG AATGCAAAAT AAGGAAGGGC CTACTTACTA CACAGAGCCA TTCTAATACC TGATGTTTGC TCTAATCCAG TTTTACTATT AATTAGTTGC TGGTGCCCAA GTTTTTACTG AGAAATGGGG ATAATTTTGG AAGTCATAAT GATGCCTTCT TCTCATAGGG TATTTTATTT GTTGTTGTAT CTCCAGGCCC CAACACAGCC TGGCTTTTAG TAAATGATCA AAAATACCTG TTGAATGAAT AAATGGAGTC ACCTGAAACA TGTTAAACAT TTGTTCATGT GTCCTAATCG TGGATTTCAG GATAGTAAGC ATCCTAAAAG GAAAGCATGC ACACTGTTCT TGCTACATTA ATTTCTCACA ATATAAAAAA AGAAAAGCAT CTGAAAAAAG CTGCCAGCCG CTGTGTCTCC TAATATCAAA CTGAGCACAG ATATGGAGAA GCTAAGGGAG AGGGATGATG GGCCATGCCT CTAACCTCAT CATGGCAAAA GTCCTGGGGG TCAGACCCGA GGAGAGCAGG AAGTGTCTTT TGAGGGATAC ATTTCCACAG TGGAAATAAT GAGACTTAAA TAAATATTAT ATACACAGTT CAACTGTTTT TATGTGTAAA GGTAGTAGGT TTTCACAGTA AGGAAGCACT TCTTTTTTTT TTTGTTTGAG ACAGAGTCTC GCTCTGTCTC CCAGCCTGGA GTACAGTGGT GCTATCTCGG CTCACTGCAA TCTCTGCCTC CTGGATTCAA GTGATTCTCC TGCCTCAGCC TCCCGAGTAG CTGGGACAAC AGGTGTGTGC CATTACACCT GGCTAATTTT TGTATTTTTA GCAGAGATGC GGTTTCACCA TGTTGGCCAG GCTGATCTCG AACTCCTGAC CTCAGGTGTT CTGCCCGCCT CTGCCTCCCA ATGTGCTGGG ATTACAGGCA TGAGCCACTG CACTCACCAA GCACTTCTAC TGATAGCATT TACAAACCCT TCTTAGAATA TTTAAAAATT CTAAGAGAAG AGTAAATTGA GCCTTCCCAA CTAATACTAG GAGGTTATAA CCTTCATACC AAAACTGGAC AATGCTTGCA CAAAAGAAGG AAGCCAATGA GGCCACCTAG AAGGAAGACT GGGCATTGGG CCCAGTGAGT CCTGGAAACC TCATCTGTGC CAGCCACCCC GGCATGGCCT GTATGAGTGG ATGAGGGTGA CTTGTCCACA GACAATAGCC ATCTAGCTGT GATAAAGGAG TCAAGGTAGT CAGCTGCATC TCTTTCACCT GTTTGCCAAT GTTACACAGG TTGAAAAGCT AAGGTTTATG TAAAGCAAGC ATCAAAGATG ATGAAATGAT CAACCTGACA ATGAGTACTA TGCTGCATTG TCCAGAAAGG AACTGTGGAA GATTTTGGGC TGAATTTCAA AACAGAATTT CCTCACTCTC TGGATGTTGG CTTACTTGGC CTTTGATGTT CAGAGGTGGT GCCTTTGTGT TGTTGAACAA TGTTGATTTT GGAGAGAAAA CAGAGTTGAA AAACCCACAA GTCATTCCCT GGGGAGTATT ACCGGAATAC AGAGGATAAT TTCAGCAAGC CAGCAAGGCC TCATCTCTGC TTCTAATAGA TAGGAAGAAA GGAAGAGAGG AACAATACTT TTTTAAGAAG CTCAGCTTTA TCGCCTTATC TCATAGAAAG ATGCCTCCAG TCTGTCTGGC TAAAGGTAAT TGGCATGGGA AAGTCTTTAT CTGTGATTCT AACAAGTGGA ATGTTTCCCT TCATTAAGAG AGCCTTGTCT GGCTTGGGGA AATGAAACAC TTTCTCCGAT ATGAGTGGGC TGTAACCCCT GCTACTAAAT ACTCAGAAGA AATAAGGCGG TTGTGGAGCA GTCAGGAATG AGTCACTTGC CTCCCTGGAA TATTCAGAAA ACTGAATCAA AAGTACATTC TTCTGGGTTT TCTTAGTCTA ATAGACTAAG GGTCTCTACT TTGTTAAATT TCTGGGAAAC AGCATAGAAT GGGAGAAAAA ACTGGTCACT GTAGTCATGC AAATCTGCAA AACAAACAAA AAAGTCTGGG TATTGCTGCT AACTAGCTAT GTGACCTTAA GCAAGGTATT AACTCTCTCT GAATTTCAGG TTCTTCATCT GTTAAATAGC ATATCTGTAA AATGGGAATT ATTTTCATAT CATAATGCTG TAGCTTTAAA AAATAAAATA AAATGGATGA GATAATCAGA ATTAAAGAGC CTGGGATATA TAGTTAATAT ATAGCAGCAT GTAAAGATCC TGTTAGAAAT GCTAATTTTA CAGTTAACCA TTTGGAGATG ATCCGCCAAA GCTGCTAGTG TAGAGGCAAC TGAGAATTTG CCTGTCCTTC AGAATATGAA TAAATAACTG TCAATGATGT CTCAAGCCTA GAAAAACCTA TCCATCTGGA TGGGTGGGAA ATTTCTAGGC TAGTATTGAG AAGCCCATTT CTTGGGAAAT AGGTCCTGGA CTGAGTGAAG GAAAAGAAAC AGTAAAACCC ATGGTAAAGC AGCAAGGCTC TCTAGAGGCT CTGGAGAGGA TGAATTGAAT TCTAGAAGAT GAAGTAGGGA AGACGCTTTA CCTTCTTGTG AAATGGATTC AAAGATTCAA AGACCTTCGG GAATCTCCAA TTGTATAAAT GGCACCATAG CTGTATGTTC CATGGAACAC TACTTCCCAG AGATGCCCAG TGAAAAAAGA ATGCCACAGT CAAATAAGTT TGGAAACACT CCATTATGTG GCCACCTCCT TGAAGACTCT AATGCACATT AGCATGTTAA ACAGTCTTGA GAAGTCCTGC AGAGCAGAAA TTGCTTCACA TCTGCTAAGC CGGCAGTTTC CCAATATACT TGATTATGGA TAGTTTTTTC CTTACAACAC CATTCTCTGA TATGCTTCCA ATGACATGAA bPl-109 162

ATAAATATAT ATGCATGAGG TTCTTCATTA GGGCATACTT TTTAATAGAA AATATTGAGA ATAATCTAAA TATAAATGCA CAGCATTTAC CTTTTCTGCA TAAACTATAT ACAGGCATAC CTTGGAGATA CTATGGGTTT GGTTCCCACA ATATCTCCAA AACCACATTC GGTTTTATGA CCACTGCCAT AAAACCAGCC ACATGAATTT TTTGGTTTCC CAATGTATAT CAAAGTTACA TTTTTACTAT ACCATAGTCT ATTATATATA CAATAGCATT ATATCTAAAA AACAACGTAA ACACCTTAAT TTAAGGCTGT GGCTGGTTTG ATTTTCTACC CAGACCACTA AAACTTTCTT CATATCAGCA ATAAGGCTGT TTCACTTTCT TACTATTTTT TGTGATAGCA CTTTTCCTTT CCTTCAAGAA TTTTTCCTTT CTATTCACAA TTTGTTTGAT ACAAGAGGAC TAGATTTTAG CTTATCTCAG TTTAAGGTGT TTACATTGTT AGCTAAAAAT GCTAATGATC ATCTGAGACT TCAGCAAGTC ATAATCTTTT GCTGGTGGAA GGTCTTGCCT CAGTGTTGAT GTCTGCTGAC TGGGTGGCTT TGGCAATTTC TTAAAGTAAG ACAACAATCA AGTTTGACAT ATCAATTGAC CCTTCCTGTC ATAAATGATT TTTTTTTTCT CTGTAGCCTG CAATGCTCTT TGATAGCATT TTACCCACAG TAGAATTTTC AAAATTGGAG TCAATCCTTT CAAACTCTGG TGCTGTTTTA TCAACTAAGT TTATGGAGTA TTAGAAATCC CTTGTTGTCA TTTCAACAAT GTTCACACCA TCTTCCCCAG GAGTATATTC TACCTCAAGA AACCACTTTC TTTGCTCATC TATAAGAAGC AGCTCCTCAT CCACTAAAGT TTTATCCTGA GATTGCAACA ATTCAGTTAC ATCTTCAGGC TCTACTTCTA ATTCTAGTTC TCTTGCTGTT TCTATCTCAT TTGTGCTTAC TTTCTCCGCT GAAGTCTTGA ACCCCTTAAA GTCACTCATG AGGGTTGGAA TCAACTTCTT ACAAACTCCT GTTGATGTTG ATATTTTGAC CTGCTCCCAT GATTCATGGG TATTCTTAAT GGCATCTAGA ATGGTGAACG TTTTCAGAAG GTTTTCAGTT GGCTTTGCCC GGATCCATCA GACGAATCCC TATCTATGGA AGCTATAGAT TTATAAAATG TATTTCTTTT TTTGTGGGGG CATAGCGTCT CACCCTGTCA CCCAACCTGG AATGCAGTGG CACAGTCATA ACTCACTGAA GACTCAAACT CCTGGGCTCA AGTGATTCTT CCACCTTGGC CTCCCAAAAC ACTGGATTAC AAGCTTGAGC CACTGTGTCT AGCCCAAAAT GTATATCATA ACTAATGAGG CTTGAAAGTC AAAGTGACTC CTTGATCCAT GGGCTACAGA ATGGACGCTG GGTTACCAGA CATGAAAACA ATACTCATCT CCTCATACAT CTCCTTCAGA GCTCCTGGGT GAGCAGGCCC ATTGTCAAAT GAGCAGTAGT ATCTTGAAAG AAATTTTTTT TCTGAGCAGT AGATCTCCAC AGTGGACTTA AAATAGTCAG TAAACTATGC TGTAAACAGA AGTGCTGTCA TCCAAGCTCT GTTTTTCCAC TGATAGGGCA AAAGCAGAGT AGATTTGGCA TAATTCTCTA GGGCCTTAGG ATTTTTGGAA TGGCAAATTG AGCATTGGCT TCAACTTTTT TTTTTTTTTT TTTTTTTGAG ACAGAGTCTT GGTCTGTCAC CCAGGCTGGA GTGCAGTGGT GCAATCTCGG CCCACTGCAA GCTCTGCCTC CTAGGTTCAC ACCATTCTCC TGCCTCTGCC TCCTGAGTAG CTGGGACTAC AGGCACCCGC CACCATGCCC GGCTAATTTT TTGTATTTTA GTACAGACGG GGTTTCGCCA TGTTAGCCAG GATGGTCTCG ATCTCCTGAC CTCGTGATCC ACCCGCCTCG GCCTCCCAAA GTGCTGGGAT TACAGGCGTG AGCCACAGCG CCCAGCCTGT CTTCAACTTA AAGTCGCCAG CTGTGTTAGC CTCTAATAAG AGAGTCTGCC TGTCCTTTCA AGCTTTGAAG CCAGGCATCA TTCTCTTCTC TAGCTATGAA AATCTTAGAT AGCATCTTCT CCCAATAGGA AGCCATTTTT TATGCCCTAA AAATCTGTCG TTTGGTGTAG CCACCTTCAT CATTGATCTT ACCTAGATCC GCTGGATAAC TTACCACAGT GTCTACATCA TTACTTCTGC TTCACCTTGC ACTTTTATGT TATGGGGATG GCTCCTTTCC TCTAACCTCA TAAACTAACC TCCACTAGCC TCACATTCTT CTTTTACAGC TTCCTCGCCT CTCTCAGAGT TCACAGAATT GAAGAATGTT GGGCCTTGGA TTACACTTTG GTTTAAGGGA ATGCTGTGGC TGGTTTGATT TTCTATCCAG AACACTAAAA CTTTCTTCAT ATCAGCAATA AGACTGTTTC ACTTTCTTAC TATTTTTTGT GATAGCACTT TTCCTTTCCT TCAAGAATTT TTCCTTTCTA TTCACAATTT GACCGTTTGA TATGAGAGGC CTAGATTTTA GCCAATCTCA GTTTACACCA TGCCTTTTTC ACTAAGCTTC ATCATTTTAG CTTTTTATTT AAAGTAAGAT GTGTGACCCT TCCTTTCATT TGAACACTTA CATGATGATG CCTGGCTTCA AAGCTTGAAA GGACAGGCAG ACTCTCTTAT TAGGGGCTAA CACAGCTGGC GACTTTTAAG TTGAAGCCAA TGCTCAATTT GCCATTAGAA GCCATTGTAG GGTTAATTAA TTTGCCTAAT TTTAATATTA TGGTGTCTCA GGGAATAAGG AGGCCTGAGT AGAGGGAGGG AGATGGGGAA ACAGCCAGTC ATCAGAGCAC ACACAACATT TATCAATTAA GTTTATCACC TTGAGGGCAC AGGTCATGAT ACTTCAAAAC AATTACAATA ATAAAATAAA AAATCATTGA TCGCAGATCA CCATAACAGA TATAATGATA ATGAAAAATT TGAAGTATTG TGAGAATTAC CAAAACGTGA CACACAGACA CAAAGTGAGC ACATGTCATT GGAAAAGTGG TGCTGATAGA CTTACTTCAT GCAGGGTTGC CACAAATACT CAATCTGTAA AAAATTCAAT TATCTACATA GTACCATAAA AACAAGGTAT ACCTGTTTAT ATAATCAAGA CCAACAGAAC CCTAGAGAAA ATAGCTCACT CCCTAGCTCG GAGACATTCT AACCAACATA CACTTACCTT TCTTTTTGCT GTGTACAGAA TTCAAATCCC TGTCTCAGCA AAATTGCAAA GTATCAAATG TCATGTCCAT CTAATACTCA AAACTGCAAA TGTTAAGTCT TGTAAGCCCA GAGACCACTG TATATACAAG TGTTGCTATA AGCATTAGTT CTTCTCCAAA GAAAATAGTC CACTTGGTAG AAACAAACAA AAAGAAAAAA AAAGAAAGAA AAAACATTTT TTACAAGAAG ATTCAGTCTC TTACCTACAT AAGCAAAAAT ATGAGATGTT CTCTTATCAT TTTTCCATCT ATCTTATAAT CTTTGGTGCT GACTTAGACA CTCATTTTCC TTTTTGTACG TGACCATGTA AAAGTTCAAG TCAAGAAAAA CTTGTTTTGA CATTTGTTTT GCTGAGTGAT GGGTCCCTAA AAGAAATTTG GCTTTGCTTT TGAAAAGTTC AGCATGATAT TGTGTGAATT TTTCATGGCT AATGATTTTT AGAACAGTTG TGATGTGTTT AGGTGTTTTA AGAATATGAA GCATTCAGTG GTTTAAGTTG GTTGTTATAA AATGAAAGAA TATGAAGGAA AGCCTTCTTG TCTTAGAACA CACTGATTCA CAAATAAGCA GCTTCTCTCA AAATGTTGTA ATTACAAAAA TTCCAAGGCA AATATAATAA ACTCCTTGTC GGTGCTATGT CTAGAAACTT AACAGCCCCA AAGAAAGTCC TGACAAGGCA AAAAATATAT ATATATATAC AAATTGTGGA AGCAGGGTGT TGAAAGAAGA ATAAAGACTA TATAAGGACA AACTGTTTAA AAGGGAGGGT ATCCTTGAAA GCTTGACACT TGACTCTTTT GACGAGGCTG AGGGAAAACA CTCAGTTTCA TAGATTGCTG GTACGGATGT AAAATAGTGA CATCCCTATA GAGAGGAATT TGGCAATATC TAGCAAAAGT GCTTATGCAT TTATTCTTTG ACCTAGTAAT CCCGCTTCTA GGATTAGTGG TGAAGATACA CCTCAACAAT AAAAATATAT ATACATTAGG TTATTAGTTA TGGTTTAATT TTTAATAGCA AAATATTTAA AACAACCTAC ATGAACAAAT AGGAGACTTA CTGAATAAAC TATGGTATAT CTGTACAATA AAGTGCAATT CACTTATGTT GTTAATTTGT TCCAAAAATC CAGAGCCAAA GAGTATTTGT TATGCTCTCT TTAGTATAAG AAAGGGGAAA TAAGATATGT GTGCATCTGT TTATTTTTGT GAAAATAAGT ACAGAAAGGA TAAGTAAGAA ACTAGTAAAA CTAGTTATCT CCTAGTGTTA GTAGAAATAG AATGAAAGTG AATTAGGCTT CTTTGAGTAT ATGTTTATAT ATAGTTTTGA CTTTTGAATT ATGTTTATGT TTACATAGTC AAAAATATAA ATTAATCAAC AGAAATAACA AAAAAAGAAG AAATCACAAG CTTTAAAATT TAATACAAAC AGAAATAATT GAATCTAACA GTATATCAAA GTGATAACGT AAACTCAGAA GAAAAAAACA TAATCCAACA TACCAGTGGA ACACAATATT CTAACTGTAT ACATTCAGTG GTTATAGTCT AAGGACAAGA AAAATTGCAA AAATATCTTG AACTTTAGCT TGTAGGATTT TTATTGGTAG CAATACTAAT GTACTAATTC TGAAATTAAT GTTCGTGTAT TATAGAATTG AGTAAATGAA TAAATATGTT GATGTTATTG GGAACTAAAA TTATCATTCT GGGAGTAGAG AAATATAAAT ATGGACTTGG CAAATGAAAC AAAGACCTGC AGAGAGATAA CCATATAAAC TCATTATTTT AAAAATTATA AGTGTCCTAG CTCTGTTACT GAAAAGGCCT AGATTCAATC TTATCTTGAT AGACAGGAGG GCACCCCTTT CTCAGAACAT GGTTTCCAAA TGCCATTCTC CATTAAAAGG AACAAGGTCT TCTTGGAGAA AAGACTGATT CTAGGTCTGG ATTAGGTAAA GTACAACGTT AGTCTGGAAT TTCTTGCTGA ATCAGAAGTA AGAAAGTGCT CAAAAACATG GGAACATGTC ACAAACACAC GTGAGGCAAC TTGAATCCTC ACTGGCCATA TTTAGGACAA TCGAGCATCA AAAAAAAAAA AAATGTTGAG AATAATGGAT TCTAACACTT AAAACAAAAA ATAATCCATA GCCCACAGAA GGGGAAGAGA GGGGGAGCTC TTATTTACAG ATGAATATCA AATAGCAAAG ACAGAAGAAA TGACAGAATT AGAGAAACAT CATTTTGCAA AACACCACTG TAATAATCAA TTCAGGCAAG TATTATTAAT GGATGTATTA CTATTGCGTA AAACCAGTTG GGGAACAGGA TATTCATACA GTCTGAAGGT GTCACCCTAA ACATAACTTA TTACAAGTGG AAAATGGTGC CTTTACAATG AAGAAATCTA GCAGAAACCA TCTTAATCTA GTGATCAAAC TTAGTATCAC CAATAATGGA TCATACTGAG TCATGTGTCT CCTAATATGA TGCACCAGGA AGGATGCAAC GTCATGAACG TTGTATTCTT TTGTATTCAA CAGACCACCC AGGGTAAAGG CAGCTTTCTC ACTTACTAAT CAGAATTGTT GGTTTTAATT CATTTTGGAT TTTAAGATTT CTTACTTTCT TGTCAGCTCA GAAATTTATT TAAGATGATT TTTATCTTTT ATTCAATACT TTAGCTTGGA GAACCATTCA GAGTTTCTAA tPl-109 163

CTCATTGTAT TGCCAAAAAT AGAAAACAGC ATGGTTTCTT TTGAAAATGT CTAACTTTAA AGTTACTTGT GTGTGTCACT CAGATTCACA TAGCTTTTTT GCCTAGTAAT GTAGTATCAT GTGGCAAGGC TATAAAAATG TTTACAATCT TTTATTTAAT ATGACTCTTG AGAGTTTATT CTAAGGAAAT AATTGAATAG TAACAAAACA CTATTAACAC AAAGCATAGC AATTTGATTT GGGCAACCAA ACACTGGAAA CAACCTAAAT GTCCATTACA GGAATCATTT ATGAAGCAAA CACTAAAATA TTTATTGTGA AGATTATGAG AACATAGAAG ACAGTTATGA GAGTAAATTT GAAAACCTGA ACACAAAACT TACATATACT CCAATTGTAA CTTATAAAAA ATACGTGCAT ATAAGGATAA AACAGTACAA ACAAAAAAAT AGTTGCGTTA GATTGGTAGA ATTATGGCTC CTTTTGCTGT CTTAATTTTT TCCTTTTACA TTTTGATACA TTATTTTAAT TTTAATTTTA AAATTCAAAA GAATTTGCCA CTCATCTTTG CCACTTCAAG GAAAAAAGAA ATGTGTTCGA TTATTCTGTT CTTAGTATAG TTTTGGCAAT TTCCTCACGT GTAAAAAGAG AATACTATTA ATAATTTCAG TATCTATAAG ACAATATAAA ATTAAAGAAT CTAGCCCAGT AACTGGTACA TGGAACGTAA TTAATAAATC ATTATGGACT TTTTTTCTCA CACCCAAGTA GGGAGGAATC AGTGGTCCCC TAGAGGCCCA GTGTAGAGGT GGCAGCACCA ATCCCTAGGG GAGAAGATCT TGGTGATGAT AATTCCTGAG CAGACAGTTA GCTGAGAATT CAAGAGCAGA AAAGTAAGAA AGAAACAACT TCTTGCTAAC ACCTTTCCAC CCACGTTTCC CTGTTCTGTT GTACTCTGCT TACCCTTTCA TGGATGGAGG CAGAGGAAAG AGAACCAAGT TTGCTCTTAG TCATTCACTA TGTTGTTTAA TCTGCCTTCC ATCTTTCTTA TCAGTTCAAA TTAGAATGTA GACCTGAATT TAAATCCCCG TTCTGTCAGT TATAATGTGA CCCTAGACAA AACACATTCT CTGAACCTCA GAGAACATTC TTCATTTGTA GAATGGGAAG ATTAATCTAT ATTCCACTTG GATGGCAAGT CTTTTATAAA CTTTATAACC TAAACATGTG TGAGTTGCTA GTATCATTAT GTTGGTAAAG TTATTCTGAG ATATGATAAC AGAACTGTTT TGTCTAACTC CACTAGCATG GTTCAGGTTT AGAGAGTGTG GAATTAAAAG GCTTTATCCT CAAATATGAC TTAAATCCGA TTTTTCTCAT CCACTTTCCT CCACAAACAA ATCCTCAGGA AATGACAAAC TTTACATGGT TAAACATCAG TTTTGTTTAG TCTTTGACAT CCACATGGTT AAATCATACA TTTGAAAACT GCTTATATTT GTGTTGTCTA TGTCTAAATT GAAAAGACTT ATTGAGGAAT AGAAGACTAC ACATTTTTCA GCAAACACTG CACGTTTTGC AGAATTTCCC CAGGCACCAG TCTCCAGGAA TTTATTGGCT ACTAACAATA CTAAGATATG GATGAATGAG GAAATCAAAA TGGAGATCTT GCAAGTTTTG TGAGAATGGG TGAATGGTCC AAATGAAGAG ATAAGTTGTG AAATATTAGT ACAAGTAAAA ATTATTTACA ATGAAAGACA TTTTGTCAAT AGCTATGAGA ATTTTACCAT TGACCCAGAA ATTCCATTTC TTTCTTCAGA AATACCCACG TAGGTATACA TATAAAAAGT TATTCATTAC AGTATCGTTT TTCATAGGAA AAAGTTTTAA AAATCAGAAG CTATCTAAAC TATGGTATAT CTAGGTCATA GAAATCAAAT GACTAAAAAT GTTAATATAA GCATATGTTT TTAAATTAAC TTGGCTTGGG TCTTCAGCAA AATTGGCTTC TTAACATTGC ACTCCAGAGT TAGACTTACC CACTCAGTCA CTTATCATGC AGGAGCAGAC TCCTAATACC ACATATCATA GAGCAGAGTA GGACACAGGT TCTCTGCAGG CAGGCAAATC CCAAAGAGAA GGGAGGAAAG GGCTGAGACA CTGCATGGTC AATTTCTTCT GAACTCTGCA ATGTACGGAG GTGGACAGTG TCCACAAAGA TTGCTCCCCT GGACCCACCA TCATAATAAC ACAACGGCTT TGTTTTGTTT TTGTTTTTGT TTTTTGACAC GGAGTTTTGC TCTTGTTGTC CAGGCTGGAG TGCAATGGTG TGATCTCGAC TCACCACAAC CTCCACTTCC TGGGTTCAAG TGATTCTCCT GCCTCAGCCT CCTGAGTGGA TGGGATTACA GGCATGCACC ACCATGCCCA GCTAATTTTG TATTTTTAGT AGAGACGAGG TTTCTCCACG TTGGCCAGGC TGGTCTCAAA CTCTTAACCT CAGGTGATCC ACCCGTCTTG GCCTCCCAAA GTGCTGCGAT TACAGGTGTG AGCCACCGCG CCCAGCCCAC AATGGCCTTT TGTTTACATC TCTAGTGCAG CACTCATTTC ATGTTCTTTC AAGAAGAATA CATATTTCAT CTTTTTATTT TATACAGCAA TTAGCACAGT GCCTGGCATA AGGAAAATGA TCATTAAAAG CTGGGTGAAA AACCTAATAA AGCTACTGAG GATAGGAACT GCAGACCAGC ATGGAAAGAA AACTATGAGC CAGATATTGA CATCATCCTG AAAGGCAGAA GATTTAGTAT AGGCAAGAAG TATGCTTTTG GAATATAGAA AATCTGGATT ATGATAAGAA AAGAATCATA TTTGTCTTAT CTTACCTACT CACTTCTCAG TTCCACATGT TTCTGAGGCT GTTTGTCCTT ACTTTCTTTT CTGTTTTATC CACTCTTTCT GTTCTTTAGA TTGGATCATT CCTATTGAGC TGACATCAAG TTAACTGACC TTTTATTTTG TCCAAACTGC TGTTAAATGC ATCCAGTGAA TTTTTAACTT TATATAGTAT ATCTTTTAGT CCTAGAATTT CCACATGAGT TTTTTAAGTT TCCATTTCTC TGCTGAGATC TCCTATTTGT TCATTCATTA TGACCATATT TTTCTCTACA TTATTGAGCA TAATTATAAC AGCTCTTCTA AAATTCTTGT CTGCACATTC TAACACCTGA ATTATTCTGG GGTCAGTCTC TGTTACATTG CCTTATTACA AAAACAGTAT AAGTCACATT GCCTTGTTTC TTAATATGCA AAATGATTTT TGATTGCAGA CTAGACATTT TGAATTAAAC ATTATAGAGA TTCTGGATTC TCGAGAGAGT ATTGACTTGT TTTTTCCATC AGGCAGGTAA CTTGACTGGA CTCAAACTCC AAACTCTAGG TCCTCTGTAA TGGGCAACTG CAGTAATCTT TGTTTAGTTC TTTAAGACTT ATTGGCCAGG CACGGGGGCT CATGCCTGCA ATCCCAGCAC TGTGGGAGGC CAAGGTGGGA GGATCACCTG AGGTCAGGAG TTCGAGACCA GCCTGGCCCA CATGGTGAAA CCCTGCCTCT ACTAAAAATA CAAAAATTAG CCGGGTGTGG TGGTGGGCGC CTGTAGTCCC AGCTACTCAG AAGGCTAAGG CAGAAGAATC ACTTGAACCT GGAAGGCAGA GGTTGCAGTG AGCCGAGATT GTGCCACTAT ACTCCAGCCT GGGTGACAAA AGCGAGACTC CCTCTCAAAA AAAAATTTAT TGGCACTGCT TGGCATCTGC TATGAATACA TGAAGTTCAT GGGTCAGCTA TAGATCTGGG CACGTTATAC ACAGAATTTG GGTCTCCCTT TCTCTGGATT TCTCCTTTTC TGGATTTCTT TTCTCATTTT CCAGCAGCTG TGGTTGCCCT AAACTCGGTC CTCTGTTTCT TTACGGCAGT AAGATTTGGG AACTTTTAGG TTTTACCTGC CTCTCAGACA AAATAAAAAA TAATTTTCAT CTTGATGCTA CTCCTTTCTT CCAGATGTAG ACACCTCTCT AATTTCCAGT TGCTTTTTAT TGCTCTCCAG AGTCTAAAGA TTATCATTGT TTTCTGTGGG AGAGTTGGTC TGATAAAAAC TACTCCCCCA AAACTGGAAG CTGGAAGCTT GTAATTATGA ATAGACTTTG AGTAGTATTC TTCTTTGGAA AAGGATTTTA ACTACTCCCT ATGTACTTCT TTATTTCCTG TTTTTCTCAT CCGTAATCTT TTTATTTTCA TACTTCCTAA GTCAGACAAT TTTCCTACTT GAAGATTCAG TGACTGCTAT CAAATGACCC CCATATTACT AAATACAATA TCCCCAACTG CATTTATAAA AAGAAAATTT ACTGTTTATT AGTAAACAAT GTTGTAGAAT AGTAAAATAT TGCTGGGCTT TGGAGCCAGA TAATCAAGGT TAGAATCCCA GATTCTAACT TACTAGCTGG TGTATTAGTC CTTTCTCATG CTGCTAATAA AGACATACCC CAGACTGGGA GACTGGGTAA TTTATGAAGA AAAGAGGTTT AATTGACTCA CAGTTCAGCA TGGCTGGGGA GGCCTTAGGA AACTTACAGT CATGGTGGCA GCAAGGAGAA GTTCCAAGCA AAGAGGGAAA AGCCCCTTAT AAAACCATCT GATCTTATGA GAACTCACTC ACTATCACGA GAACAGCATG AGGGTAACTG CCCTCACGTT TAATTACCTT CCACCAGTTC CCCCCCATGA CACATGGGGA TTATGAAAGC TATAATTCAA GATGAGATTT GGGTGGAGAA ATAGCCAAAC CATATAATTC CACCCCTGGC CCCTCTCAAA TCTCATGTCC TCACATTTCA AAACTCAATC ATGCCCTCCC AACTGTCCCC CAAGGTCTTA ACTCATTCCA GCATTAAGTC AAAAATCCAA GTTCAAAGTC TCATCTGAGA CAAGGCAAGT CCCTTCTGCC TATGAGCCTA TAAAATCAAA AGCATGTTAG TTACTTCCTA GATACAGTGG GGGTACAGGC GTTGGGTAAA TACACTGATT CCAAATGGGA GAAATTGCCA AAACAAAAGA GTTACAGACC CCATGCAAGT CCAAAACCCA ATAGGGCAGT CATTAACATT AAAGTTCCAA AATGATCTCC TTTGACTTCA TGTCTCACAT CCAGGTCACA CTGATGCAAG AGGTGGGCTT CCAATGGCCT TGGGCAGCTC TGCCCCTGTG GCTTTGCAGG GTATAGCCTG CTTCCTGTTT GCTTTTTCAC AGGCTGACAT TGAGTGTCTG TGGCTTTTCC ATGAGTATGG TGCAAGCTGT TGGTGGATTT ACCATTCTGG GGTCTGGGCC AGGTGCAGTG GCTCATGCCT GTAATCCCAG CACTTTGGGA GGCTGAGGTG GGGGATCACA AGGTCAGGAG ATCGAGACCA TCCTGGCTAA CACGGTAAAA CCCAGTCTCT GCTTAAAAAA TACAAAAAAT TAGCCAGGCG TGGTGGTGGG TGCCTGTAGT CCCAGATACT TGGGAGGCTG AGGCAGGAGA ATGGCGTGAA CCCAGGAGGT GGAGCTTGCA GCGAGCTGAG ATTGTGCCAC TGCACTCCAG CCTGGGCGAC AGAGCAAGAC TCCATCAAAA AAAAAAACAA AAAAACCATT CTGGGGTCTG GAGAATGGTA GCCCTTACAG CACCACCAGG CAGTGCCCCA GTGGGGACTC TGTGTGGGGG CTCTGACCCC ACATTTCCCT TCTGCACGGC CCTAGTAGAG GTTCTCCATG AGGGTTCTAC CCCTGCAGCA AACTTCTGCC TGGACATCCA GGCATTTCCA TACATCCTCG GAAATCTAAG CCGCGGAGGT TCCCAAACTT CAATTCTTGA CTCCTGTGCA CCCACAGGCT CAATACCACA TGTAAGCCAC CAATGCTTGG TCAGGGCTTG AACCCTCTGA AGCAATGGCC TGAGCTGTAC GTTGACACCT TTTAGCCTAG ACATCTAGGA CACAGGGCAC CATGACCCGA AGCTTCATAA AGTGGGAGGG CCTTGGGACT AGCTGAGGAA EPI-109 164

ACCATTTTTC CATCCTAGGC CTCCAGGCCT GTGATGGGAA GGGCAGCCAT GAAGGTGCCT GACATGCCCT GGAGACGTTT TCCCCATTGT CTTGGTAACT AACATTCAGC TCCGTGTGCA GCACCAACTT ACTTATGCAA ATTTCTGTCA CTGGTTTGAA TTTCTCCCCA GAAAACAGGA TTTTTCTTTT CTATTGCATC ATCATGCTGC AAATTTTCAA ACTTTTATGC TATGCTTCCT GTTGAAGACT TTGCGGCTTA GAAATTTCTT CCCCCAGATA CCCAAAATTA TCTCTCTCAA GTTCAAAGTT CCACAGATAT CTAGGGGACA AAATGTTGCC AGTCTCTTTG CATAGCAAGA GTGACCTTTA CTCCAGTTCC CAACAAGTTT CTCATCTCCA TATGAGACCA TCTCAGCTTG GACTTAGTTG TCCATGTTAC TATCAACATT TTGGTCAAAG CCATTCAACA AGTCTCTATG AAGTTTCAAA CTTCCCCATG TTTTCCTGTC TTCTAATAGC CCTCCAAATT TTTCCAACCT CTGTCTGTTA CCCAGTTCTA AAGTCACTTC TACATTTTTG GGTATCTTTA CAGCAGTGGC ACTCCCCATG GTACTAATTT ACTGTATTAG TCTGTTCTCA TGCTGCTAAT AAAGACTTAC TCGAGACTGG GTAATTTATA AAGAACAGAG GTTCAACTGG CTCACAGTTC AGCATGGCTG GGAGGCCTCA GGAAACTTAC AAACATGGTG GCAGCAAAGA GAAGTTCCAA GCAAAGAGGG AAAAGCCCCT TATAAAACCA TCAGATCTTG TGAGAATTCA CTATCATGAA AATAGCATGA GGGTAACTGC CCCCATGATT AATTTACCTC CCACAGGGTC CCTCCCATGA CAGGTGGGGA TTATGGGAAC TACAATTCAA GATGAGATTT GGGTGGGGAC ACAGCCATAC CATGCCAGCT AGAGAGCCTT AAGAAAGTCA CCTAATCTCC ACAAATAAAA GGTTTCCTAT TTGTTCAACA AAAATAATGA CACCCCTTTT ATGGGATTTC TGTGAGGACA AATGATAACT AACATAGCCT TGCATAGTGT CTGGCACAAA ATAGCTACTC AAAAAATAAT AGAAACAACA TTTAAAAAAT GTAGACTTTA TTTTTTAGAG TTTTATGTAC AAAGCAAAAT TGAGCAGAAT GTACAGAGAG TTTCCGTATA GCACTCCCTA CCCCCAAGCA CAGATAGCCT CCCCCAGTAT CAGCATCCCG CACCAGAGTG GTACATTTAT TATAACTGAT GAATCTATAT TGACGTGTCA TTTTCATCCA AAATCCATAG TTTATATTAG GGATGCCTCT TGGTGTTGTA CCTTCTATGG GTTTTGACAA ATGTATAATG ACATGTATTC ACCATTACAG TATCATAAAG AATAGTTTCA CTGTCCTAAA AATCTTTGAT CTTCTTCCTA TTCATCACTC CCTCCCCATT AATCCCTGAC AACTACTGCT AATTTTCCTG TCTCCATTGT TTTGTCTTTT CCTGAATGTC ATATAGTTTA AATATACAGT ATGTAGGATT TTCAAACTGG TTTATTTCAC TTAGTAATAT GCATTTGATG TTCTTCCATA TCTTTTCAAA GCTTCATAGT TCAATATTTA TAGAATTGAA TAATATTCCA TTGTCTGGAT GTACTACAGT TTATGTATTC ATTCACCTAT CAAAGAACAC CTTCGTTGCT TCCAAGTTTC AACAATCATG AGTAAAGCTG CTATAAACAT CTATGTACAT GTTTTTTTGT GAATTGAACA TTTTCAGCTT TTTTAGCTCC ATTCCTAGGA GTGCAATTGC TGGATTGTAT GATAAGGGTA TGTTTAGTGT TGTAAGAAAC TGCCACGCTC TTCCTAACTG GATGTACTGT TTTGCATTCT CACCAGCAAT GAAAGAGTTC CTGTTGCTCC ACATACTCAC CAGCATTTGG TGTCGTCAAT GTTTTGAGCA ATAGCATTTT GATCTAACTT TTCCTAGGTA TTCTTTTTGA AGGAAATAAT ATGACAGATA ATAGAGAAAG GATATACGAG GACAGTTCTG TCCTTTATTT ATAGTCCATC ATTTAATGAA GGACTCTGTC CACACTTGGT ATTTTTAACT CTGATCCTCC TCTCCCATGA ACTCTGACAA TCTCCTAAAT CCCTGTTGCT GGCACACATG GTTGTGTATC AGGCCCCCTG TGGTCTGTCT GAAGCATGGC TTTTTTTTTT TTTTTTTTTT TTTTTTTGAG ACGGAGTCTC GCTCTGTCGC CCAGGCTGGA GTGCAGTGGC GCGATCTCGG CTCACTGCAA GCTCCGCCTC CCGGGTTCAC GCCATTCTCC TGCCTCAGCC TCCCGAGTAG CTGGGACTAC AGGCGCCCGC CACCACGCCT GGCTAATTTT TTGTATTTTT AGTAGAGGCG GGGTTTCACT GTGTTAGCCA GGATGGTCTC GATCTCCTGA CCTTGTGATC CGCCCGCCTC TGCCTCCCAA AGTGCTGGGA TTACAGGCGT GAGCCACCGC GCCCGGCCTT TTTTTTTTTT TTTTTTTTTT TTTGAGATGG AGTCTGTCAC TCTGTCACCC AGGCTGGTGC AGTGATGCAA TCTTGGCTCA CTACAACCTC CATCTTTCAG GTTCAAGTGA TTCTGCCACC TCAGCCTCCC AAGTACCTGG GATTACAGGT GCCCGCCACC ACACCCAGCT ATTTTTTTGT ATTTTTAGTA GAGACGTAGT TTCACCATGT TGGCCAGGCT GGTCTCATTC CTGACCTTGA GTGATCCACC TGCCTTGGCC TCCCAAAGTG CTGGGATTAC AGGCATGGGT CATCACATGT GGCCTGAAGC ATGACTCTTG CTTTAATCAT ATGAAATACT GCTCTGTATT GTTATCTATT TGAAATGCCA CACCTCCTGA GCTAAATTGC AAGCTTTTAT GGAGCACAAA CCATATTTAT ATATATTAGC ATGATACCAT GACACATATC AAAAGCTGTT ATATATTGTT ACGTGAATTG ATTCTTTCTC AGTTAAGAGG ACCTCTGTAG TAGCACTTTC ATACCGTTAA TTTTTCATTT TGTGCCCAGC CCCTACTCTG TGAAAAATGA AATGAATCCT GTTATCATTT CCCTCCCAGG CCTTTTCTCC TTGTGGACAA TGTGTGGCTC AAGAGAAAAT TCAGTCAGTA AATTTGTTCA GTGCACAAAC TCTTTATCAC CTCTCACTGT TCTCAAGTGA GATAGAACAG AACATCCATC CAGTGTCTTA CAAATTGTCT GGTATATAGT AGGCACTCAA TAAATGTTTT TTGAATAAAT GCATACATGA ATCCTATTCC TATATATAGT ATGGTAGACA GATCATTGAT ACCCAAAGAT GCCCAAATGC TGATCCCCAG AACTTGTGAA TATGTTACAT TTCATGTCAA AAGGGACTTT GCTAATGTGA TTAAGGATTC AGACCCTTGG ATTGTAAGAT TATCCCGGAT TAACCAGGGC CAATCTAATC ACATGAGACC TTAAAAAAGC AGAAAACATT TCCCAGCTGG GTTAGAGAGA GATGAGACAG AGTAAAAAGG AAAGAGATTC AGGGCATGAA AATGACTCTA CCCACTGTTG CTGGCTTTGA AGATAGAGGA ACTAGGCCAC AAAACAAGGA GTATGAGTGG CCTTAAGAAA TAGGAAAAAG CCCTCATCTG ACAGCCAGCT AGAAAGCAGT CCTCTGACCA CAAGAAATTG GATTCTGCCA ACCACTCAAA TGAGCAAGGA AATGGATTCT CCCCTAGAAC CTCCAGAAAG GAACACAGCT CTGTAATGCC TTGATTTTAG CCAGGTGAGA CCTGTTTCAG ACTTTTGACC TATGGAAATA TAAGATAATA AAGTTTTATT GTATGCTGCT AAATTTGCGG TAGTTTATTA CTGAAGCAAT GGAAAGCCAA TACAGACAGA ATATACAGAG AGAAAGAGAA TGAGTTCTTT CCTGATAATT TGTAAATATT TGGGTCTTCA CTGGACAAGC TTCACAGAGG ATTCACTGGT TCCCTAGCAA ACCAGCATGT CCAGTCCTGC AGCCTCCCTT TCTTAGGCCC AGCATATGTC AGCTGTGTGC ATAGAAAAAT CAAAGCAGGA CCCTGAGTAG TTGGAAAGAA AAGATGGTTG GAAATGGGTT GCACTTCAAG TGAGGAAACA AGAGGTAGGA GACCGGCATC TCTTTCTCAT ATGTCCCAGG CTGACTCTTG TGAGTTGTTT TCCCTTGGAG GCTATCGATG ACAGTCACAG TAACCTGATG GAACCTGGAT CATGATGAAA GAAGTAAGTG TCAATGGCTC CGACTTCCAA GGACTCTGAT GTCCCACAGC ACTAGCTAAA CAAAGCCAGT TGGAAATGAG CTTAAATGGG GAATTTCCTG AATATATTCC CTATTGTTAG GAAGCCAGGT TGGCTTCCTT GCCTACAATT ATGCCAAGCA GTCACACTAT AGAGTCCCTA GGGACATGAT ATTAAGTGAT TCTTTTAACA CAAACAACTT AATAATCATT TATACTAATA GCAAAACGGC CAACGGCTGA TATTCCACTT GAAGTAGAAT TGGCTATCCA ACTGGAAGAG AAGACAGGAA GACGTGATCT CCAGGGAGCC ACTAAAAGGA TTGGCACCTG CCTCTGGATT CCCCTTTTCC TTATATTACC TCTCAGCACT GGCAGGCCTT TATTTCAGGA TACAGTTTCA CAAGTATTAT GTCACGTCTC TGAGAATTAT GTTGGTAGAT ATTTGCTCCT CTGGCCAGAA AGACCTAGTT TGGAGTCTGG AGTCATGAAG GTGACATACA TGTAGCTAGT GACATAAGTG TAGCTAGTAA AAATAGTGAG TAATGGCCCT GAAATTCTAT TGAATGCCCA AAGTGCTGAC CAGGAACAAG CATGCTCTAG CTTATCTCAC AAGGAACTTG ACAATTTTCT TCAAAAATCC TAGTAGCTAA GATTTCTTAG TAACAAAGCC ACTAAGGCAC AATTATGATT AACTTGACCC TTAGGTGACT TTTAAGGACT ATTCTATAAA ATATTACAAC TAATAGTGGA TCCAAGCCAG CACACTCTGC TATATAAGAT TAATTGACAG TGTCCACACT GGTAAAATAA GTTGTTTCAT AAATACATTA GAATTCATTT GCACTTTCTA CACAGCCCCA AGTCCAGAAC TTTCCCCAGA ATAGGTCTAT GTTTTGCAAT CTGCTACTCC ATACAGAGAT TTCAGTTCAC TTGGCAATTT AGTGCTGCTT ATATGTGACC AGTTAGTCTG TTTTACTTAT CTATGCCTTA AACATTACTA TACTTACTAA CTCCAAGATG CCTGGTCTCA ACTTGACAAA AATACCCCAA GTTGGGAAAT CCTTATGTGA ATATGTAGAT AGTCACAATT GCTGGTTGAT GATGATCTGT CTTTTCCTGT ATTTGAGAAA ATGGAGATAA AATGGACCAA TCCAAATAAT GGATTAAACA TGGGAATAGG TGAGAGAGAG AGAGGAATAC ATGGTGGCTC TCAGTGTCTG GCTTAGGCAG TAAACACTTT CGTTAATAAA GACGGAAAAT AAAAAAGGAA TAATTGGTGT CTAGGGGAAA ATAATGAGCT CAAGTTTTAA CACTCTGAGT TCCCGGATGT GAGACATCCA GGCGCATTTA TCCAAGAGGC AGTTGGAAGC AACGTTCCGG AGCTTAGGAG AGAGGCATGA CCAAAAGCTG GTGGGACTGT GAAAAGGTAT GGCCATTCTG GAAAACTGTT TGGCAGTTTC TTAGAAAATT AAACATGTAC TAACAACCCA GCAATTGTAC TCTTGAGCAT TTGTCCCAGA TAAATGAAAA AAAAAAAAAG CATTTTTTTT ACACAAAAAC ATATACATGA AAGTTCATAG AAGTGTTATT CATAAAAAAC TGGAAAAAAC TGAGATGTCT TTATTGAGTG AATGCTTAGG CAAACGGTGG TCTATCCATA CAATGGAATT ATGCTTAGCA ATAAAGAGAA AAGAACTATT GATACATGCA ATAACACAGA TGAATCTCAA AGGAATTAAT EPI-109 165

GCTGAGTGGG AAAAAAAGCA CATCTCAAAA TGGTATATAC TGTACTATTT TATTTACTTA ACATTTTAAA AATAGCAAAA TCATAGAGAT GGAGAACAGA TTAATGGGTA CTGTGTTTTG GGATGGGGAG TGAGAAAAGG GTAAGGTGTA AATATAAAGG GGTAGCACAA AAGAGCCTTG TGGTTGAAGG ATTCTATGTC TTGGTTGTAG TCGTGATTGC AGGAATCTAC ATGTGATAAA ATTGTATGGG TCTACATACG CATACACACA AGAGCATATA AAACTGGTGA CATGTGAAGA AGCTCCGCAC ATTGTGCCAA CATCAGTATC CTAGTTTCAA TATCAGACTA CAGTTATACA AAACATTGTC ATTGAGGGAA ACTGGGTAAA GGGAACACAG GACATTTGGC ATATATTTTT GCAATTTCCT GTGAATCCGT AATTATTTAA AAATAACAGA TATACTACAT ATCAAAAATT TAATGTCATA AAGTTGATGA GTTTACCTAG TGGATAGCTT TGTTAATATC TGCTATAAGA CTACTGAAAA TGACAGTTAT GCAAGTATAA GCTCAGAGAA CTTTCCTCCC CCTTCGTAAA TGAAATGAGC AAAAGAAATG AAACAGGAAA GGCAAGCAGT ACTGAAAACA GGGAAGGGCT CTTCCCCATA TAACTATATC TGCGACTTCA ACAGCTATTC ATCCAGAAAC ACAGCCTCTT GCGCTAAGAG GAAACTTTGG ATAACAATAT GTTTTCACTC TCCAAGAGAG AAAATGGATA GATTAATTTT TAAGAAAAAA AAAAAAACCT CACCAATTTC ATGCTGTGGC TTGCACCTTT AATCCCAGCT ACCTACAAGG CTGAGGTGAG AGGCTTACTT GAGCCCAGGA GTTCAAGGCT GCAATGAGCT ATGATTGATT GTGCTATCGC ACTCCAACCT GGAGTACTAA GCTAAGAGCT AAGAACACAG CTGAGAGCGG AGAAGAAACA AACAAATCTG ACCAATAACC CCCACTCCCC TCATTTTACT GGAGTGAGCT GAGACTGCTG GCAAACATGG CCTTTGACCT AGCCTGAACT GTAGCAAAAG TCATCAGATA TTTTTCCACC AATCAACAGA CAGAAGTGGG GAGAAAACAA TCGTAGTTCA TAACTACAAC AAGCAGATAA ACGAAGGCCA TGGTGAGGGA TGGAAGACAT TGTGATATAT CAAAGGCAGG CTCATTTAAA ACTCAACCCA AATTCCAAAC AAAATATATA ATTGAATATG TATTAATGCC AAAGGAGCTT GAGTGAGCTT TAGCACAAAC CCCGCCCTCC AGCCCCCACC CAAAAAAATC ACTCTGTTCT CTCCCCATTC TTTGATAGGC ATACTTGCTG TTTTCTCACA GCCAAGGTAC AGAGGGGACT TAGAGGAACT AGAACTCTAA TACACTGCTA GCAGGAATGT AAAATGAAGC ATCTACTTCA GAAAACCATT TTATCAGTTT CTAGAAAGTT AAACATAGAC CCACCATGCA GCCCAGCCAC TCTACTCCTA AGTATTTACA CAAGAGAAAT GAAAACGTGT CCCCACACAG TTGTATTTAA AGGTGATGGT TAGCCTTGTG TGTCAACTTG GCTAGGCTAT AATACCCAGT TACTGAATCA AATAGTAATC TAGGTGCATC TGTGAAGGTA TTTTGTAGAT GTGGTTAACA GCTACAATCT GTTGACTTCA AGTAAAGGAG ATTGCTCTTG ATAGTATGGG TGGGCTTCAT CCAATCAATT GAAGGCCTTA AGAGCAAAAA GTAAGGTTTC CCGGAGAGAA AGAAATTCTG CCTCAAGACT GCAGCCTCAA CTCCTGCCTG AGTTTCCAGT CAGCCAGCCA GCCTAAAGAT TTGCTAGGCA TTATAATCAC ATCAGCTAAT TTCTTAAAAT AAACCTCTTT ATATATATTG ATACAATGAA TGGTTATAGC AGCCTTATTT GTAATAGCCA CAAACTGGAA ACAACCTAAA TGTCCTTCAA TAAGTGAATA CATAAACAAA TTGTGGTATA TCCACAATTT TTACGCAGCA GTAAAAAGGA ATAAATGGTT GAATAAGGAA TAAACACATA ACAAGGATGA ACCTTAAAAC CGTAAGGCTG AATGGAAAAA GTCAGACAAA ACTAATACAT ACTGAATAAT TCCATTTATA TTGAAGTTCT AGAAAATGAG GACTAACCTA TAGTAACAAA AAGCAGAAAA ATTTTGCCCA CTGGTGATGG AGGGGGCGCA GGTATTGTAG AGTATCTGAG AAAGGACAAC TGGATAAAAG GGGGCACAAG AAAACTTTTG AGGGTGATTG ATATGTTCAT TATCTTGTGG CATGGTTTCA TAGGTGCATA CATATGTCAA AACATCAAGT TATACACTTT TAAAATGTTC AGTTTACTGT ATATCTATTA TACTTCAGTA GAGAGGAAGG AAGAAAGTGG GCAGGGTGGG GGAGAGGAAA GGAAACGAGG GAGGAAAGGC CCTAATAGGA AGGATTTTGG AGTTTAGATT TTAAAATGAT AAAGGATGTT TGACACTCTA GGCATATGAC GAATATAGGA TTATGAGTCC ACAAAAACCA CCAGGAAGTC ATGTATGTTT ATACTTTTAA GTGAAGGATC AGTGGATTAT CAACTCCCTA ATGCTTTGCC TCTCTATGAC TGGCTGCTGT CCTTCTCATC CCAATACTCC TTCCAAAGCC CCTTGCTTAA ATGTAAGCCT TCTTTCCTCC TTTCAACACA TCCTGCATTC CGTGACAAAA TAAGTTTTCC TTAAACAGAA TGTACAGCAT ATTATTTGTA CAATTAAAAA TTTTTGGCCA GGTGTGATGA CTCATGCCTG TAATCCCAGC AATTTGGGAG GCCGAGATGT GTGGATTACC TGAGGTCAGG AGTTCGAGAC CAGCCTGGCC AACATGGTGA AACCCTGTCT CTACTAAAAA TACAAAAATT AGCTGAGTGT AGTGTGGCAG GTACCTGTAA TCCCAGCTAC TCAGGAAGCT GAGGCAGGAG AATCGCTTGA ACCTGGGAGG TGGAGGTTGC TGTGAGCAGA GATCAGACTA TTGCATTCTA GGCTAGGAGA CAGAGTGAGA CTCGGTCCCC AAAAAAAAAC ACATTTTTTT TTAATGTTTC CTCCTTGCCT GTAGGAAAAA GGCTCTGACT CCTTAGCCTG GGCATCAGAG CTCTATCTAA ATGGACTTTA ACCTGATTTT GTGGCACTAA TTCCATTGCA GTACTTGTCC GCTCACTGGC CTGTGCCTCT CTGCCACTAT TTTTGGAATA ATGTCCTCTC TCCATCTTGT TTACTCAACT ATATCCAACC TCTAAGGCTG TGCTCCTACA AAGCCTCCCC TGGCTACTTC AGCCCACAGA GATATTTAAC TGCTCTGCAG TTCAGGACAT TCTTCTGACT CTTTAAATCA CATTTACTTA TATATGATCT TGTGATATTT TTTGTTGACG TGTTTACTTT AATTTTCTTC CATAACCTAT TCATTCAACA AACTCAACAA TTATTTATTA AATGCCAAGT TAGAAAAATA TTATTGATTT TATATAGATT ATAGATATGT TTGAAATTTT ATTTGGCAAT CTGCAAGTAG AAAAATAATT ATAATGTGGT ATATCTGTGA TAGAAGTATT AGTGCAGAGA CCATGGGGAA CATAATCCAG CCTGGAAGTT CAGGAGAGAT ACGTGGAAGA AAGGACGTCA GAGCCTTTTT CCTACAGGCA TGGAAGAAAC ATTAAAAAAA ATTTTTTTTT TTGAGATGGA GTCTCACTCT GTCTCCCAGC CTAGACTGTG GTGGTGCGAT CTCTGCTCAC TGCAACCTCT GTCTCCCGGG TTCAAGTGAT TCTCCTGCCT CAGCTTCCCA AGTAGCTGGG ATTACAGGTA CCTGCCACAC ATGGATGATA AATATGATCA TATTTTCTTG TTCTTTTCCT CCTCAGTTGT CTTCCCTGAA GAAAGGAATG CCTTTTATAG ATGACAAACT CCCATTCTCA AGAACAAGGA TTTTTGACCA ATTTAATTTA ATCAGATGTC TGGCTTTGAC CTAGAAACAC AGTCACGAAA CTTGGTGATT AGAGACCAAT TCCCAAACAT GAGCATTTCT TAGGAAACAC AGTAAAGATC TGAGAGACCC AAGAGCAGAA GGGCGAGAAA CCAAAAGCCA TCAGTTTGCA TAGGAAACAC CTTGTTTAGC CTAATCTTTT TATTTTTATT ACTCTATTAG TCACTACAAC TATTTTCTGA TTGCTATGGT GATAGATGGT TTAAAACAAG CCTTCATTAA GAATTGTCAC ACCATGGTCT CAGTCAAAAA CACCAACATT TTTATTGGTA TTGACAATTA TGGGAATATC CAATTCCAAG AAGACAAGGA GACCTCTGAA CTTTCTAAAT GAAGACTCCA ATCTTCCTGA TCTGATGGGA AGCAGCTTGG CAAGATTACC AACCACCACC ACAGAGAGTG GACTCTAAGC TAAGACTTAA AAGATAAGTA GAAATTATCC AGGTAAAGAT GTGTACAGAG AAGGAAGTAC ATCCAGGGGA AAAGAACAAT ACGTGCAAAA GTACGGAAAT GGTAAAAAGT AATACTACAT AGTCAAAGCC AAGCAGAGTT CAGAAGGGAT CTGGTGGTGA AAAATACGGC TAGAGAAAGC AGCAAGGATT GGCTTCTAAA ACCTATGTAG TATCTTGGAC CTTACCCTAA ATGTAATGAG AAGCTTCTAA AGAATCTTTC ATTTATTCAT TCATTGAACA AATATTTTGA GGCTTTCTGT GAAGAACATC ATTCTAAGTA GTAAAGATAC AGCAGTGAAT AGGACACATA AAATCCTAGA TCTCACAGAA TTGACATTCC AGAGAGGGAA AGGTAGACAA TAAATACATA AACAAATCAT TTAACAAGAT GATTTCAGAC AATGGTACGT ACTGTGAAAA AAATGAAACA AGGTAATGGA CAGCGAAAAG GCACTGGAAG GAAGCCTGCT TACCTTTGCA TGGTTAGAAA AGATCTCTCT AAGAAAGAGA CCACATGTGA GCTGCGACCT GAAGGATACC GAGAAGCTAG GTGTGCAAAG ATGTGGGGAC AGAACTTTTG GACTGAATAG CAAATACAAA TGCCCTTGGG TGCAAGCTTT GCCTGTTCAA GGACCAAAAA GAAGGCCAGT GTGCCTGCAG CATACTAAGC ACAGAGGAAA ACACTGTTAT ATGCTGAGAT TGGAATTATA AGTAGAGCCA GATAATATAG TCTCTTATAG GTCATAATAA GGCAACCAGA TTTTATTCCA AGAGGATTTA AAAATCACTG GAGGTTTTGC ACTAGGGTGA GAGGTGTGAT TTGTATTTTT AAAAGATAAT TCTGGAGAAT TAACTATAAT GAGGTAGGAG TAAACTAAGT TAGGGGCTAT TTCAGTGGCT CAGACAAGAG ATAATGGTAG CTTAGACTAG GATAGTAGTC GTAGAAATAA ATAAAAGTGG CACTCTACTT TGGGGGTAGA GTCTATAATA GGTTTGGTTT ATGGATCATA TATGAGAGTA AAAAAAAGAA AATAAATTAA TAATGGTTCC TAGGTTTGTA CCTGAGCAAC TGAATAAATG GGTGCTGTGA ATTGAGATAA AGGAGATTGA GAATCACAGG CTTTGTTTTG CAAATTAATT TTGAGAGGCT TATTAGACAT CCCAGTGGAG ATTTCAGGTG AGTGGAGCCC ATTGAAAGGT AAGGGACAGG GTCAGGTGTG GTAGGTCAGG CCTGTGATCC CAGGACTTTG GAAGGCCAAG GCAGACAGAT CAGTTGAGCT CAGGAGTTTG AGACCAGCCT GGGCAACATG GGAAAACCCT GTCTCTACAA AATATGCAAA ATATTACCTG GGCATGGTGG CATATGACTG TGGTCCAAGC CACTTGGGGG GCTGAGATGG GAGGATCACT TGAGTACAGG AGGCGGAGGT TGCAGTGAGC CAAGATCTCG CCACTGCAAA CCAGCTTAGG TGACAGAGTG AGAACCTGTC TCAATAAATA AATAAGAAAC GTAAGGGAAA AGGAAATTAA TCTGATCATT EPI-109 166

GGCAAATGCA TAGTATTTAA AGCCAGGGGA GTAGATGAGA TACTCAAAGT AGGTGAAGAT AAGGAGGCAA TGAAGGCCTA GGACTCTGGT GTACATTTAG ATGGTTATAA GAGGAATAGA AACTGGCAAA ATAAGTAACA CTGAGCACCC AATGAGGTGG AGAGGAAAGC CAGGAGATGA AGCATCATAG AAGGCAAGAG AAGAAGGGTG TCAAAGAGGC GAGGCAGTCA TCAACTTCTG GGCAGTCAAA TAATATAAGG ACAGAAAAGT GACCATTGGA TTTGGAAATA TGATGAGCAC TTTGAGTGGA GTGTTGAGAC AGAAGACCAA TTAGAGTAGA TTGAGGAGAT AACGAGAAAT GAGAAAATGT AACCTGCAAG CACAGACAAT TCTTGAGAGA CTTTTCTGTG AAAGGAAACA GACACAGAGT CTTAGCATGT CTTGTCTTTC TATGGGAAAT GTAAATACTT TGAGATCAGG GATAGTATTT TATTCTGCTT TTTGTACCTC TACATTACCT AGCATAGAGC TAGCTAATGT GCACTTAAGT ATGTTCTCAA TTCTTATCGC CTGAATGACT GGATGGGTGA AAGAATGGAT GGATGGATGG ATGGATGGAT GGAAGGATGG ATGGATGGAT GGAAGACTTC TGATTTGCCA AGAAGAGGAT ACTGGTAGCA GAAATAAAAA CAGCACTGGA GAAAGAAGAG TTTAGATTTT TATTCTTTGG TGTCAGTTAG ACAGGAAAGT AAGACATTAG AAGAGTCCTT AGATAATTTA TGTAATTGTT CACTTAGGAT TTTTAAATGT GATCACTGAT ATTGGACATG TTCCTAGTGA AGCATTTTTG GTGTTTCACT GGTTGAAGTT AATAACTGTA AAATTATTTC CCGTTCAGGA CAGAAAAACA GAAAACTTGA AGCTCCTATT AGAAAGTTCA AGATTCTCTG GGGTTCTTAG GATTTACTGT TCCCAAAACT CTGTCAAGAA CAAGAAAATG ACCTGTATAC TTAACTGGTC TAGGCAACAG TGGAAAGACA ATTCTCAGAG AAGATTTGTT TTAAGAAGAC ACTTTCCATA GGAATCAAAC AATAGCTTTC AGTGACTAAC ATGGTAAGAC ACAGGGTGTT AGCTCTTTCC TTCCAACCTC ATGGCTGTTG TACCTTACCT TTCGACCCCG TGTTCCTGAA ATTGTTAAAT TCATAAACTT ACCAAGGACT AACCAGCCTC TGGGGAATTG CTGTATACTT AGCAAACTTA CAATGGACAT ATTTATAAGC CATAATGATA ACTGACTAAT AGGAAATACC CTCAACTGAA AATGAGAGAT CATCATTTGC AAATGAGTTC CCTTGCCCAG GCAACTACTG GGGAAAATGT CATGCAAGCA AAATTAATCT TTGAAATCCT CCTTTTCCAT TTTTTGTGTC TTCCTTTTCC ATAGGCACCA GAAATATCAT GGTGCCTGGA TCTCATCTCT ACAGAAAAAA AAAGTGATTT GATAAACTGA TTTATATTGT GTCCAAATGT GATTGTATTT TCAAAGATAA CCTAAGGGGA GAATGCTGTC TGGCCCAACA GCAGGCTCTC GACTTCATTT CAGACACTGT GGCCAATGGC TGGGAAACAG GTATGAACAG TAGGTTTCTG AGTCCCCTGG AATTATTCCA TTTATGTAGC CACCTCCATG ACAGGAAGCC TCCCTACTCT TACTTCCCAG TTTGTTCATT CATGGCACCA GGTTGCAGAT TAAAATTTGC TCAGTGACCT TTTATCTAAT AATGTGTTAC CTTCTTCTCT TAAAAAGTAC AAGGGACAAA TGCTCATGGT ATACTTTTAG GAGATTGTGG CTCTCTATTA ACAGTATTTA TTCAACAAAC ATTTATTGAG CATTTATATG TGCATCATGC TAGGGACTGG AACCTAGTAA GTGTAGCACA TATTATTTCA TTTAATCCTC ACAACAAACC CATGAGGTTG GTTTTATGAT CCCAATTTTT CAGAAGAAGA AACTGATATT CAGAACCAGT TAACTAACTG GTTCAAGGTC ATGCAATTTC TAAGATACAG AACCAAGAGT CAAAGACATG ATTTTAAACC AAAGCTTTTT CTGCTACTCC ACATTGCTTC CCTAGGTGAG ATCTGAGGCA TTCCGCGAAA AGAGAAGGGT CATAAAGCCA AGGGAAGACA AGCTTAGGAA AAAAAAGGGA AATGTCCTAA ATAAACAGCT TTCCTATTTA CCAGAAACCA CTAGTTTAAA AATATAATGG GAAAAATCCT ATTCACTTTA ACAATGTTAA AAAAAAAAAA GATAGAAGAA ACATAGGGAT AAACTTAACA CATTTGTAGG ATATGTAAAG AAACTAAAAG ATGTTAATAA TGGCCTAAAG AAAAAAAAAC TTACATGTAT GGGGAGATAG ACCATCTTAC TGGATTCTAA TATTTAATAG TCTAGGTGTT CCATTTCTCA CCAAATTAAT GTATACATTT AATACAATGT CAAACGAAAT ATCTTAGGAA TTGCTTACAA ATTGTCAGAT AATTACAAAG TTTACCTGGG AAATATAAGC ATATATGAAG AGTGAATGGG ACCCCACCAC TCCCCCCAAA ACAAAAAAGG TCTGAAAAGG ACAGAAATCA AGGAGAGTCT TGCCTGCCAG ATACAAAATT CTATTATAAA GGTGTATTGA TGAAAACAAT TTAATACTAG TGTAGCAATA GGCAGCAAAG CAATGAAACA GCATAAAAAG ACCAGAACTA TACCTAATTA TGATGAAGAT TTAAGGTATG ATAAACATGA CATAATTCAA ATCAGCAGAA ATTGGCATAG ATAGGGTTAA GACAAATAGC TAATCATTAG AGGGGAGGAA GGAAAGGAGG GAGGATAAAA TTAGGTTCCT GCCTTCATCT TACATTAAAA TAAATTCCAG ATGTATTACA TTTAAATTTT TTTAAAAAAA GAAACCACAA AATACTTGAA GAAAATATAA GTTGTTATAT AGTCTTTTGA TGGGAATTTT TTTTTTTTTC AGAGACAGGG TCTTGCTCTG TCACCTAGCC TAGAGTGCAA TGGCATGATC ATGGCTCACT GCAGCCTTGA ACTCCTGGGC TCAAGTGATC CTCCCAGCTC AGCCCCCCAG GTAGCAGGAA CTACAGGCAT GCGACACCCC ATCCAACTTA TTTTTTATTT TTTGTAGAGA CAGGGGTCTT GCTTTGTTTC CCAGGCTTAT CTCGAACTTC TGCCTTCAAG CACCTCAGCC TCCCAAAGAG CTGGGCTGAT GGGACATTTT TTAACATAGT GCCACATTAC CATAAATGAA AAGCTTGTAA AATACTAATT TTTAAAACTA ATATATATCA GAAATTTTTA TAAACAAAGT TAAAAAGCAA ACACAAAAAA TTTGTAGCAC TTATGACAAA TATATGTATA TATATGAATA CAAAAAGAGC CTTTACAAAA CAGTAAGAAA ACAATGAATA CTCCCAATGG AGTATTCAAA ACTAAACTGC TAAAAGCAAT TCAAAACAAA AAACATAAAC TATGCATATA TGTATGTGAA AAAGTTTAAC CTTATCAAAG AAGTAAACTC TCAAAGAAAT AAACATCAAA TAAGGAAATA GCCTTTTCCC ACAAATAACC AAAATCTGTA AGAATACTGA GCTGCGAATG TTTCAGAAAA AAAAAAAAAT CATACACCTA GTTCGGCATG TAATTAATAT AGATCAGAAC ACTTTAAAAA TATTTATAGG CCAGGCACGG TGGCTCATGC CTATAATCCC AGCACTTTGG GAGGCCAAGG CGGGTGGATC ACCTGAAGTC AGGAGTTTGA GACCATCCTG ACCAACATGG TGAAACCCTG TCTCTACTAA AAATACAAAA ACTAGCCAGG CATGTTGGCG TATGCTGGTA ATCCTGGCTA CTCGGGAGGC TGAGGCAGGA GAATTGCTTG AACCCAGGAG GTGGAGGTTG CAGTGAGCTG ACATTGTGCC ACTGTACTCC AGCCTGGGCA ACAAGAGCAA AACTCTGTCT CAAAAAATAA TAATAAATAA AAATAAAATA TTTATATACT CTGACCCATC AATTTGTCCA GCATAATTAG GCATGTGTAC AAGGGTTTAC ACACAAGAAT GCCTATTGCA ATATTGCTTT TAATGCTAAA AAAAATTGGG GAAAATGCTT TAAAAATATA GATTAAGACT GTACATTGTG GTACAGTCAT ATAATCAATA GTATACAGCT ATTATTTATT TTCAGCCACT GTCCAAAATA TAGCCTGGCC TAACAACATT CTGTTAGGAT ACGCAAGCAC CGTGAGGAGA TCAGCTATAA AGTATCAGTG TTTCACACCA CTGCTCCTTT GCTAATAACC TTCAATGGCT TTTAAAGAAG TAAAAAACAA AGGCAAAATT CCTTAGTCAG CCCTTAAGAC TCTCTGTTAC TTAGCTCAAA CTACCCTTTT CAACAACACT GCCCTAACCA GGATGAGTTT TTTGCCCCCC TGGAGTACAT TCAGCCTTTC CTTATCAAAC CTTCCTTTAA ATAAGTATCT TCTCCAGGAC CACTTCACTT TCTTCCCCAA TTTAGCATTT TCTATATCTC CAGGCCTACC TCTATAAAGC CTGTCCTAAC CACTCAAACC CTAGCTTTTT CTCTGAACTG CTAGAAATAT TTTTCTCTCA TTGGCCATTT AGGTAAAAAG GTTTTTACTG TTTATTACCT ACTCAATAAA AATTTTCTTT TTTTGAGACA AGGTCTTACT CTGTCGCCTA GAATGGGGGG AAGTGGTGTG ATCACAACTC ACTGCAGCTT CTACCTCCCA GCTCAACAGT CCTCCCACCT CAGCCTAGTG AGTAGCTGTG ACTACAGGCA TGTGCCACCA TACCCCACTA CTTTTCATTT TTTATTTTTT GTGAGATGGA ATCTCACTAT GTTACCCAGG CTGGTCTGCT GATCTCAATT GATCCTCCCA CTGTGGCCTC CCAAAATGCT GGGATTACAG GCATGAGCCA CAATATCTGG CCCCAGTAAG CTTTTAAGGC CATTAACATG AGGAACAGTG TTCTTTACAC TATTTTATCA GCTAGGGCTT TGCATGGAGT AGGAGTTTAG TAAATGCGGT TGATGGGTTA ATCAATGTGT GAAAATATTC AGAGCCACCA AAAACAGATA TTATGTCTAT TCTCATCAAC AATCAAAATT GAGTAAACAG CCATTTTCTA ATACAGGAAA CCACAAAACA TTGAATGGTG ACATTAAAAA ATTCCCCCAG CAGGAGCCAA CCAATTTTTT CATCCTGATC CAAGTTAGCA AACTGCAAAA GATAGGAAGC ACTAATGAGT GGAAATTTGA GTAGAAGCAT TTCTTATGAA GGCTGTCTTG ACTGGATCAC ATTTTTATTG CTGTTGGAGG TGCCAAATGT GTGTGTTTAT GCTAATCCTC CACCTCAGGC AACACACAGT CAAGGATCCT ACCAAGTGTT ACCGTCAAGT GTCTGTTGGC AGCTCAAGGC CCCAGCGTTG TTCCCTTGCA CTAGGGAAAA GACATATTCC AGGTACAAGT ACTCCCACTT TGATGCTACA GAGGAGTTGC TGAACTTTGT GTCATTAATC TCTCTTCGTT AGATCCCAAC CCTGTTTAAA TCCCACTATC TGCCTACTCT GGGTCTTCAC CAATTTACTA GATCATAGTT GGAGAAAATC TACAAAGCCT TGCTCCCTTT AGATTTAAAC AGGTCTCCGT TTAAATTTAG AATTGCTAAC TTCAAGCGGG CCCTTATGCG ACAGTATGCC TGTCAGTCAT ACTACATTTC CTCAATTCCA TTCATGTGAC TGCTCCATAC CCTTCCCTCT CTCTTCATAC TACTATTATC TCTTCCCCCC TCCCTCATTT TTAACTGATG ATCTTGTTTC CTATTTCTCT GAGAAAATAG AAGCCATCAA AAGAGAGTTT CCACAAACTC CTACTGCCTT ATCTAGCCCT GTACCATATA CTTTGCATTT CCTCTCATTA CCATGGATGT ACTGCCTATC TGTGCTTCTA TCTAAGGCTA ACCCTTCCAC TTCAGTTTTG EPI-109 167

AATATTATCA GCTCTTACCA ACTCAAGGCC ATTGCTCTAG CAATTCTCTC ATTCTCTCTC ATTTTCTTCC ATCAAGTTTT CCTTTTCTTC AATTAACAGA GTAGCTCCTA AAGGGAAAAA AAAGTCTTCT TTTTCAATGC TCATCATCAC TGGCCATCAG AGAAATGCAA ATCAAAACCA CAATGAGATA TCATCTCACA CCAGTTAGAA TGGCAATCAT TAAAAAGTCA GGAAACAACA GGTGCTGGAG AGGATGTGGA GAAATAGGAA CACTTTTACA CTGTTGGTGG GACTGTAAAC TAGTTCAACC ATTGTGGAAG ACAGTGTGGC GATTCCTCAG GGATCTAGAA TTAGAAATAC CATTTGACCC AGCCATCCCA TTACTGGGTA TATACCCAAA GGATTATAAA CAATGCTGCT ATAAAGACAC ATGCACACGT ATGTTTATTG TGGCACTACT CACAATAGCA AAGACTTGGA ACCAACCCAA ACGTCCAACA ATGATAGACT GGATTAAGAA AATGTGGCAC ATATACACCA TGGAATACTA TGCAGCCATA AAAAATGATG AGTTCATGTC CTTTGTAGGG ACATGGAGGA AGCTGGAAAC CATCACTCTC AGCAAACTAT CACAAGGACA AAAAACCAAA CACTGCATGT TCTCACTCAT AGGTGGGAAT TGAACAATGA GAACACTTGG ACACAGGAAG GGGAACATCA CCCACTGGGG CCTGTTGTGG GATGAGGGGA GTGGGGAGGG ATAGCATTAG GAGATATACC TAATGTTAAA TGATGAGTTA ATGGGTGCAG CACACCAACA TAGCACATGT ATACATATGT AACAAACCTG CACGTTGTGC ACATGTACCC TAAAACTTAA AGTATAATAA AAAAATATAT ATATATATAT AAAACAACTA AAAATAAATC TTCTTTTTCT GCAGGATCAG TCCATCACCA CACACACAGG CTGTGTTTTA TGTTGTTCCC CAGCTTAAGA GATCGTTCTC CAGATCCCAC TGCTCCTTCC AGTTGTCACC TCAGTTCTCC ACTTCTTTTT GCTGATAAAC TACTCTAACT AGTTACATAT GATTTCTGTC CCCAGGTCCC CTCCCTCAGT TGTTTTGAAC ATAATCATTT ATATCATTTA TCATTTTCAC TCTAATTGCA CAACCAAAAA CTCCCTTTTT TTTTAGATGG AGTCTCACTC TGTCACCTAG GCTGGAGTGC AGTGGCATGA TCTCGGCTCA CTCCAACCTC CGCCTCACGG GTTCAAGTGA TCCCCCTGCC TTAGCCTCCT GAATAGCTGG GATTATACAC ATGCACCACC ACACCTGGCT AATTGCTTTG TTTTTGTTTG TGTGTGTGTG TGTTTTTTTT TTTTTTTGGA CAGAGTCTCA CTCTGTTGCC CAGGCTAGAC TGCAGTGGCA TGATCTCAGC TCACTGCAAC CTCCACCTCC TGGGTTCAAG CGATTCTCCT GCCTCAGCCT CCCGAGTAGC TGGGACTACA GGCATGCACC ACCATGCCAG GCTAATTTTT TTGTATTTTC AGTAGAGACC AGGTTTCACC ATGTTGGTCA GGCTGGTCTT GAACTCCTGA CCTCAAATGA TCTGCGCACC TGGACCTCCC AAAGTGCTGG GATTACAGAC TTGAGCTACT GCGCCGGGCT ATTTTGTGTT TTTAGTAAAG ACGGGGTTTC ACCATGTTGT CCAGGCTGGT CTCAAACTCC TGACCTCAAG TGATCCGCTC GCCTCAGGCC CTCAAAGTGC TGGGATTACA GGAGTGAGCC ACCATGCCTG GCCATAAAAC TGCCCTTTGT TAATATGACT GTTGGCCTGC ACATTGTCAA ATCCAGTGGC ATTCATCTTA CTCGGCCAAC CTACGGCATT TGACACTGTC TGTCTTTCCT TCTCTTCCTC TATCTGTTTC CAGTATACTG GCCTGGCTTT CTTTTTACCT CTTTTATATG CTCTTCCAGT CTCAGGCTCC TTTGGGGATT TGAAGGTATG TTGCATTTTG CTATTCAATG AATAATGACA AGTAATGATC ACTTAAGACA TTAAGTGGTC AGTTCCTTTA CTAGGATAAA AATAATTTTC TTCCCAACAT GGGGCATATT CCATTTCCAG TCTGACTGTT CTGTGTAATC TTTGTATTCC TTGGCAGCCC CTTTTATATC AGTTCATCTA CTGTGCAGGA AATTGGACAA ACATTTGCAC TGGTATAACC AAATACAGTT GAACTTTTGG CTTGACTCTT AGCTGAACTC ACCAAAAATA ATTTCTGTAA GAGACTGAGA CGTCTACGAG TAGGTTTTTC AGAATTAGTA AACATAAATC AAGGATACAC AGGTAGATTT GAATTTCAGA TAAACAACAA ATACTTTTTT AGTATGTCTA CTGAAATATT TGTATCTTAT CTGGCAATTC TACCTGGTAC AGAACTAATC CATTCTCTTG AAAGATCTTG ACTCTGTAAT AAGTTCTTTG GTGATGGAAG GGAGGTATTT CTGTAATTAG AGTCACTGTC TTCCTCCCAG TTTTTTATCC TGGCCCAGAT CTGCAATGAA CACACGACAG AATCCAGGGG GGATGAAGAT GGGTGCTTTG CAGGAAAAAA AAATTAAAAA CATCTGAAAA AGCTTTTGTA CTAAAAGAAT GTGATCTAAA AAAGAAAGCA GGAGAACTTT CTGTCTGCAC TTTACATCAG AACAACCTTG GCGTCTAGAA GCTGTGCCCT GTGGGAAGTG GTGGTGCTTG GTAAGAGATG CCAGGACCAG TGGTACCCAC TGGGAGCACT GCCAATACCC AGCAAGGAGC ATGGGTGCAC AGTAAGGCAT TGCACTGTGA TTCAGCATAA AATAACAATA AGGGAACGTC ACGGAGAAAA GGCCAGACTT CCTTTGTTTA GAATGTGGGA AATGTCTTCT GAAAAATGGT AGTAAAAAAG CATGCTTGGA TGGTCCACTC CAGGCAAAAC TGACTAATCG GGGGTCAGGG ATACAACCCC TGCATCATAT GTTTGTTTCT GTTGGGCTGA CATGAGGTTC ACTGTGACCA CTGTGGTTTA ACCCCATAGT CTCCTGGAAA TACAGCCAGG TCAAGAGAGC TCCACATAAA ACATAATCAA AAAAATAAAC TCAAGTTTCC ACTGATCAGC TTTTCACAAC TCTTATCCTT TCACTAACTT TGGAGCAAGA TTTGAGAATT GGATGGCTAT TTGAGGGCTA TTTCTGCGCT TTAGTTCAAT GTTTTGTTCT TTCTTTATTA GAGAACTATG GTTTTTTATT ATATTTACAC TTTAAGTTCT AGGGTACATG TGCACAACGT GCAGATTTGT TACACAGGTA TAAATGTGCC ATGTTGGTTT GCTGCACCCA TCAACTCGTC ATTTACATTA GGTATTTCTC CTAATGCTAT CCCTCCCCCA GTCCCCCACC CCCCGACAGG CCCTGGTGTG TGATGTTCCC CTTCCTGTGT CCAAGTGTTC TGTTTATGTG ATAGATTACG TTTATTGATT TGTGTATGTT GAACCAGCCT TGCATCACAG TCACTTGCTT ACAAGAAACA AACACTTCAC AGATGGATCA TTATGTGTGA TAAGTGAAAT CCAAGGATTT ATGCTCAGAG GTGGGCTTAA CAGGTAGGAA GAGCAGTATT TTCCTTCAAC CATGAGTGTA TGCAGGTTTT TCTTTTCTTT TTTGAGATGG AGTCTCACTC TTTTACCCAG GCTGGCGCGC AGTGGTGCGA TCTTGGCTCA CTGTAACCTC TGCCACCTGG GTTCAAGCAA TTCTCCTGCC TCAGCCTCCC AAGTGGCTGG GATTACAGGC ACCTGCCACT GTCTCCGGCT AATTTTTGTC TTTTTAGTAG AGATGGGGTT TCACCATCTT GGCCAGCCTT GTCTTGAACT CCTGACCTCA TGAATCATCC TTCTCAGCCT CCCAAAGTGC TGGGATTACA GGCATGAGCC ACTGCGCCCA GCCCACAGGT TTTTCAAAGA CTAAACTTAA AAAAAAAAAA AAAATTTCCC AATGAAATAT AAAACTAAAG TGCTAAACTG TGATAGACTG TTTTACAAGA ATGCCAGTTT TCACAAGTGT CTATAGAACA TGTAATTTAG ATAGGTAAGA TGAAATTTTG ATAATATTTG ATGGCAAATT TAAACAGGTA TACAACAAAA ATAAAATTCT AAGCCCCTCA ACCAACTGAA TGGACTCCTT CTCTCAGCCA AAGGAATACC AAAGTAAACC TGAAAAACTA GTTTTGGCCA GGATTGGGGG TAGGTGGGGG AAGCCCAACA TGACTCATTA TTCTCTCCTC CCTTTGGAAT TCAGGCACAA CTGAATGTCA GCATTGACAC TAAAACACAG ATCTTAAGAC TGACAAGCCA GACTCTTTGT AGCAGAGAGC CAGGCCCTGG AAGAAATCAA GTTATTTTAT CCCAAAAAAT ATTTCTTTGA TATATTTTCA AATGGCCCTG CAAAGCTGTC TCTTGTGGGG AAAATTGACA TGCTGTACAG AATTTCCTTC TCTTTCCAAG TTTTTACTGA TCCAGGAGAG ATTTAACTAA GAGGCTAGCA TGTTTTTTTT TTTTTTTTTT TGAGGCGGAG TCTTGCTCTG TTGCCCAGGC TGGAGTGCAG TGGCGTGATC TCAGCTCACT GCAACCTTCG CCTCCCGGGT TCAAGCGATT CTCCTGCCTC AGCTTCCCGA GTAGCTGGGA TTACAGATCC ATGCCACTAT GCCCAGCTAA TTTTTGTATT TTTTGTAGAG ACAGGGTTTC ACCATGTTGG CCAGGCTAGT ATTGAACTCC TGACCTCGTG ATCCGCCCAC CTCGGCCTCC CAAAGTGCTG GCATTACAGG CGTGAGCCAC CGTGCCCAGC ACAAGACATT TACCGTCTAT TCTCTCTGAA GCTACTATCT AGAGGCTTCA TCAACATAAT AAGACCCTTG GTCTCCACAA CTCCTTATCT TATCCTATTA GTTTCTACTG ATTCCAGGTC TTTAGATAAT AACAACTCTT TCAACCAATT GCCAATCAGA AAGTCTTTGA ATCCACCTAT GACTTAAAAG CCCCACTCCT TCAAGTTATC CCGCCTTTCT GGACTGAACC AATGTACACC TTATATGTGT TGATGGATAT CTGCCTGTAA CTTCCATTCC CCTAAAATGT ATAACATCAA GCTGTAACCC AACCACCTTG GGCACATGTT TTCAGGAACT CATGAGACTG TGTTGCAGAC CTTGGTCACT CATATTTGGC TCACAGTAAA CTTCTTTAAA TATTGTATAG AGTTTGGCTT TTTTCATTGA CACAGGAAAA ATAAAGAATT GGAAGGTCTT TCATCAGTCA CTGAGCCAGC TTCATATCTG ACTGAGGTCA TACAGTTCAG TGATTTGTAG CTTTGCTACT TAGATTGCTA TCCATTATCT AGAAGCATCA GGATCACGTG GGACCTATTG GAAATGCAGA CTTTCCTCCT AGAACCCAGG ACCTTGGAAT ATTCTTGGCA CATAGTAGGT GCTCAATACA TATTGAACTC CTAGGTGCAA TTCATTAATT CATGAATTAA TGAATTAACA CGCTCTCAAA GTTTAGTGCT TTTTCACAGA CTAGTCTTTC TGCCTCTTAA GCACTCAGCT CACCACGCTT CCAGTCTCAC TCCCCTATTA GTCTGATTAA AATCTGCTTA CATGTGAGTC TGAGATCAAG TGTTATCTCT TCTGAGAAGT CTTCCCTCAC TGGCCCAAAG GAATTTCTCC TCTATTTTAG CACTGTCCCA GTTGACTTGT CATTATTCTA GTCTTTTTCA TATTAGTTGT TTTTCATATA TATGTTATTA AGGAAACTAG TCATTTCCCC TAATAGAACA AAATTGCTGG CCTTTGGGGT TGGCAATGGA GGGGAGGCTC TTCTTGAAAA GGGGGAAGAG TGTTCTCCTA ATATTTTTCT TACGAGATTT ATGTTGCTCA TCTTTAGCCT TTAGTCCCCC ATTGCCTGCC TACAGTTGGC AGAGACCATC TGTTCTCTCA CTGTCAGGAA CTGTCTCAAT TCTTGAAGTT CAGAGTCAAA AAAGAAGCAA EPI-109 168

GTTTTCCTAG CTCTTTGATC AACTTTCAAA GTTTTACTTC CATTTGAAAA TTTACTAAGT CACCAGGAGA TGGTTTATAC TGAGAAATAT CCACTCATAC TCTTCCTCTT CAACTTTCTT CCATATACAC CCTATTACAG GGATATAGTC TTACTCTATA GCTCAAAAGG ATGACCCTAT CAGAAACCTG CACAGTATGT AAAACATTCT CACCAGAGGT TCACTTGTGT ATTTCCACCC TAGAATGGAA GCTCTACAAA AGCACAGAAT GTATCATTTT AACTTTAGAT TCTATTTTCA CACCCAGTGC TTGACACATG ATTTGAAGTT AATATTTATT TATCAAGTGA TTGTTTTAAA ATCATGACTC ACTCAACAAA GTTATAAGAA TAAGAATAGT GTTACAGAAT TGGTATACAC AAGCTGACCA TAATCAACAC ACCTATTATC ATTTTTTTGC GACAGGTTCT CGCTGTCTCA CCCTGGCTGG AGTGGAGTGG CATGACCACG GTTCACTGCA GGTTTGAACT TCCAGGCTCA AGCAATCCTC CCACCTCAGC CTCCCACATA GCTGAGCCCA CAGGTGTGTG CCACCATGTC CAGCTAACTT TTTAATTCTT TGTAGAGACA GGGTCACCCT ATGTTGCCCA AGCTGGTCTT GAACTCCTTG GCTAGAGAGA TCCTCCCTCC AAGGTCCCCC AAAATGCTGG GATCTCAGGC AAGAGCCACC ATGCCTGGCC ATAATCAATA CACTTTTAAG AATGCTAGAA TGTTATATCA GATGCATACT TCAGCACTAT CTCAAGCAAA CTGGGGTGTG GGTTATTCTA CATATAAAGT TCAGCAGTGT TGTTCCACAG TCCCAAACTC CAACTGAGGT CAAATGTAGG GTGCAGCAAG GTCACTGGGG CTGTCATCAA GGGCCTCTCC TTGCACTCTT GCCAACCCTG TTTCTTGATT GTCTCTACCA CCATGAGTCA CCAGCAATCT CCCACAGTCA CTTGTTTAAA AGTTCACAAG TATTGTGTGA ATTGCAGGCA ACCCCTTGAC TCCCTGATTG CCTGGTCTTC TTCCTTGGGC TCTACCATTT TTTTTCCCCA GCACTCTTTC TGCTGCTCTA AATTTTAATT CATGCAATTC CATATGTGTT TCTCTATCAT TCTTCATCTC TTTCCTCTCC CTTCCATCCA ATTTTGTTTG TCTGTTTGCT TGCTTGCTTG CTTTAATACA TTTCTCTTTT TCTGAGAAGG CTTGAGTCCA AAACTCTCAG TTACCTGTTG TTCTGTTTCC CGTTAGTTAA TCTCCGAACC TTCATAAATT AAATCTGACA AAGTCCCCTG ACTAACAAAG GAAATGCACA AGTCACAGTA AAAGGGGCAC ACACAGAACA CAAATAGACC CAGGGTCTTT TCTGTTCATC ACTCAGCTTT TTATAGGAGA TCCAGGAGAA ATGAAGTGGA AAGGGAAGTG TGTTGAGTTA CTATACAACA CAAGAGTAAA CTTTCTTATA AGTGGTAATT TTTTTTTACA GGAATAATTG AAAATGGAAA TTACCTTCTC TACTCATAGT AAGTACTCAG TGCGTTCTTG ATGGGATGAG AATGTGTTTG AGCTTTAGTG TAAGGCAGAA TTCTGTTTAG TCTGCCAGTA TTGGAGAAAA ATAAAACACA AAGGGACTGA CATGTAGGAA GTGGCACCTG GGAGGGTCTC AATTCTTCCT ATTACAAAAA TGCCCCAGAG AAATAAAAAG CTTGTGTACA TGTTGAGATG GGAGAGTTCT CTGGCCCCCC TCGCAGGATG TGTGACAGTG GGGTGGCTCT CTGCTGCGCC ACCATGAGCT CAAACCCCTC ATAGGAGGGG GAGCACACAG GCAGGAAGGT GCAGGAGCTG GGCGAGCTCT TTGGGCTCTG GCCCCGTGGT ACTGTCTAGA GGTGGGTGCC TGCAACTCCT GAAAGCCCAA GTGGGCATGT GTTACAGTGC ACTCTTTCAG CTTTGCTGTC TGCAGCTTAA GCGTTAACCA GCTCAGTTTC TTCTTGGTAC CCAGGTCCTT GTCTGGCATC CAGGAAGAAT CAGGTTACAC ATGGACTTGA AGGATGAATG TGGGAGTTTT ATGGAGTGGT GGAGGTGGCT CTCAGTGGGA TGGATGGGGA GCTGGAAGGG GGATGGAGTG GGAAGATGAT ATTCTCCTGG AGTTTGGCTG TCCAGCAGCC GATCTCCTCT CCAGTCGTCC CCAGCCTCTC GACGTTCAGA TGCTCCTCTT CTCTCCTTCT CTGCCATGCT GTTCTGCCGT TCATCTGCCT GTCTCTCTCT GGAGCCTGGA ATTTGGGGTT TATATGGTAC ACAATAAGGG GCATGGCAGG CCAAAAGGGA ACTTTTTAGG TGCAAAAAAC AGGAATGCCT CTTCTCACTT AGGGCTATAG ATTTTCAGGC TTGAAGGTGG GGCCTTTACC AGCGAACCTG TATTTCCCTG TCTCCTCTGC ATATCAATGT AATCAAATAC TGGGCTGATC CAGGATGTTT CTTTAGACCA ATTATGGGTA AAATAATTTA CATTCAGGTT TTTATATTTG CTTTTGTCAT TTCTTTTTAA GCAATCATGT AAAATATCTA TACGACAGTA ATAGATGATA GCGAACCTAA TTAAAATTAC CAGAAACTTA AGAATCTCTA ATGATTTCAA CTGTAACTAA GGTTATTTCT CTTTATGTTG AACAATGTTG GGAGATAAGA CACAAGAGTT TCTGAAGTAT TTCAGAAACA CAAAGAGGGA GGTTATATAA ATAATATTTT TTTCCTACTT TGGGAAAATG AAAGCTAGTC ACAAAGTTAA ACGAGTGGTT ATTTTAATAT TTAAAATACA GGCTTGGATG TATTTCCTGT TAAAGAAAAT AAAATGCAGA ATATTCAAAA CGTCTGACCA CCCTTCTAAG AAAATGCATC TCTGAGGTAT TTTTCCTTAG AAGTTATTGT AAAAATCCTG GAGAAGCTTG AACACAGCAA AGCAAACAGG ATGCAGAGTT TAATCTGTGG AAAGCTTAGG GAAGAAAAGC AAATCATTAA AAATAGGTCT TCCTCTGAAG ATTTTTAAAA CGCAAAGAGG GTGGAATAGC AATGATAATA AAAAAGCTGG CATAGAGAGT GGCACAATTT GCTGTGCCAC TCAGCTCACT GGATGTGTTC TGAATTTCTA GGCATTAGTG TACCTTTCCA CACGCATTCT CCCTTTAAAA AAAATGCCCA CACACTGAAT ACTTTTTTCA TGCAATTTAA AATAAGCGCA CCATCTAGTT TACAGAAATT CACTAGAAGT TATTTATCCT AAAATAGCAG AGATCTAGAA GAATTTTGAG CTCTAGGACA TTTTAGACAC ACAGAAAGAA GAATCTGGAC AAGTCTTGAC CAGACATGAC AGAATAGAAA TTTCTTTTCC TATTTATCTC TTTGAATAAA ATTTTCAGGA TCTTACAGTG GACAAGTTTG TTATCTACAC ATTGTGAAGC ACATTGATTT CTCCTCTGTA GCCTTAGGAA GATCTGAGAG GTGACTGAGC TGATTGAATG ATCCGTGACC GCTCTACTGG GACCAGTAGT AGAACTTTAC TGGTGGAGAC CTGCTGGAGG TTTGAGAGCA GACTTTGAAA ATTACTAGAG CTACACAGAT ACTGTGTGGC TAACTGGATT ATGTTTAGAG GCTTTCAGAA CTATGCTGCT GCTGCTGCAG TGTAGCCAGG ACGCACAGAG AACATCTAAG GCTCTTGAAT GGGGCGATAG GGACAGATTT CAGCAGCCAT CTGACTTCAG TGCTCATTTT GATGCTTTCC CTGCAGGGTG CAGTGTGCAG TGTGCAGTGT GCAGTGGTGG GAGGCTCACA CAGGAATACT TGCTTCTGTA GCCCTAATTT CCGGTTCAAA CTCTGCATTC ACCTTGACAG ATTCTTTCCT TGGCCAAAAT TTAGTTAGGC TTCTGGGCTT TCTCTTATGC CCACCTGCAG ACTTTTTGGT AAAATCCAGT TTTAGTAAAG AGCTCTGCTA AGTCAGTTTA GCAAGAATCC CCACCTCAAA AGTCACTATC TCCCTCCCTG GTAGTGTCTG GCTTGTCTTC AGCGAGAATT CTATTAGGTT CTGTTAGATT AGAATCCTCC TTACCCTTGA TGCTTCCTCT TAGTATTTTT TCATCCACTG ACTCCTTGAC CCACCTTGCT CCTCGGCTAT AAATTCCCAC TTGCCCATAC TCTGCAGTTA AGACTATTTT CTCCCCACTA CTGCAAAATC CCATTGCCAT GGTCCCTATA CTATCTCAAT GGTAATGAAT AAAGTCTGCC TTACCATGCT TTAACAAGTA ACATTGAACC ATTTTTTTCT TTAACAATCT GCTGCACAAT GAGATTACTA AAACTTTATT CCATTTTGCC ATGCTGGATG TCCTCAATGG AATGGCTCTT GTGAGCACCA AATCATTGTG AGAAGGAAAA CCCATCTCTT ACAGCCCCCT GTAACGTGAT GTATGTTACA TGTGATGTAT GTTACATAGT TTTTTTTCAT GTTGATCACT TTTTGCCCAT TTTCCTATAT CTTATCAGTT GGAAGACTGT GGAAGTTTGT AGTACTAAGC CACAAGATGA CTAAGAAGAG TTGAAAGGGC AAGTGGGGCT AAAAACAGAT TTTGTTTGAC TTACCCCACC ATTCCCCCTA TCATGGGGCT GAATCTGCCT GGAGGAAGGA GCATCTTTAT CTTTGTACTG TGAACCACAC AGTCTAGCAG CAGCACAGCC AAGGCACTTG GGGTTTCATG AGACTAAGTA CATGCAATTC TATTGTAAAG GCTTAAAATA TATACAACTG ACCCTTGAAC AACATGAATT TGAATTGCAT GGTCAGTTAT ACGCAGATTT TCTTCCACCT CTGCCACCCC TGAGACAGTA AGATCAATCA ATCCTCTTCC TCCTACTCCT CAGTCTACTC AAAGATACTT GAAGTCTACT TGAAGATGAC AAGCACAAAG ACATTTATGA TGATCCACTT CCACTTAGTG AATAGTAAAT ATGTTTTCTC TTCCTCCTAA TTTTTTAACA CTTTCTTCTC TCTAGCTTAA TTTATTGTTA AGAATACAAT CTATAATACA TATGACATAC AAAATATGTC TTAGTTGACT GTTTATGTTA TCTGTAAGGC TTCAGGTCAA GAGTATGCTA TTAGTGGTTA AGTTTTCGAG GAGTCAAAAG GTGTATGTGG ACTTTCAACT GCAGGGGGGT GGGCACCCCT GCCCCCATGT TGTTCAAGGG TCAACTTTAC TGCCAAAGGC AAGCCTTTAC ATCCACTTTT TCCATCCCAT CAGTAAATGG AAAAAGATAG CTACAGTATC CCTGCGTCAA ATCTTTTTTT TTGCAGATCA CAAATTGGCC ACTCACCTTG CTCTGTGAGG GGTAAAATGC CCCACTTTCT TTAGTAATAT TTAAGTTAGA TAATATTTAA GTTATAAAGT TGTTCTTTGT AATCGTTAAT TGTAATTTTT ACATAGTTTC TTTCAAACAG AAATAGCATT TTTGTTAGAT AACCTCCCGT ATAGATGATG AAACTCCTTT TAAGGGCTAT CTGAATTTTA ATTCCTTGAA AAGGCAGAAA TTGGATAGCT AGTAGTCATA AATGTACTGT GGCTTCCCCC AACCATCTGG GCTATATAGA AGCTGCATCC TTGGACTGCA GTAGAGGAGT CTTACAAAGC ACAGAGCAAC TTCTCTCCTG GGTTGCGCTA GTTATGATGG CAATTTTAAA TGTGTACTTT TACCCAAAGA AAATCCTTAT TATCAACAAT CACAATGCCA TCATAACCAT GGTATAAAAA ATTCAAAATG TCCCAGCTGA AGTGGAGGCA AAGACTCAAG TTCATGGAGT CAGAGTTTCC TTGCTATTCC TCTTTTTCAA ATGACCATTT AGTAAGCACC TGAAGAAAAT ACTATGGACG GCATTGAAAA GTGAAGATAG GTTTAATCTT CTCGAAAATC TAATTCTCCA GATGAAACGC TGACACTTAT CCACCCCACA GACCCTATAG CAGATGTGTC ACTGGCCATC ACATTTGACA EPI-109 169

CAGAGAAGTC ATAACTCAGT CAGCACAGAG ACATTTCCAT GAGTTTCTGA ACCATGGACA GAACGTCGTC TGTGGGACAT GAAAACTGGA ACTTAGAGGA CAGGCACATC TGAGAAATGG GCAGTTTAAA GGCAGAACAT AGCACATATG TGACTGGGTT TTAGAAGCAA ATTTACAAGA CGCACTCTTC TTCATCCTAA ATAATCTGCA ACCAAAGCTT CCAAAAAAGA CAATTTAGGA ATGCAGAGGT GAGGAGTAGG GAGGGGAATG GGATGAGAGA GAGTGGAGAT TAATGGTGGG CAGAGCGAGG TTTAGAACTT AGTGGTTTCT TCAGGTTCTG AACTGAAATT TGTATACTGT AAAGGCACAA ACACCATTTT TAACAAAAGT GAGCAGGACT TCCTATCTGG TTCAGAAAAT AGGTGAATAA ATAGTACGAA TTATTAAAAA TAATAATTTC CACTTATACA TAGGAAACTT GATAGGAACC ATGATAAATG CTTAACTCTT AATCTTCAAG GAACTCTGCT AGGGATATAA TATTATAAAT CTTGTTTTGC AGATGGAGAA ATTGAATTTT AACCCAAGTT ATCATAACCC TTAAATGATT AAATGATACT GTTACATGAG AAAGCTGCGT ATCTGTTTCC TGGATTTGTA GCCATAATTT GTGTCTCAAG TCCCTTTTGC TGCCAGCTAT CTTGGGTAGG TGTGTTCCCT TTGGGCTGTT TGATACCCCC ACATTTATCT TTTTTTTTTC TCTTTTTTTG TTGAGAGAGT CTTTCCCTGT TGCCTAGGCT GGAGGGCAAT GGCGCGATCT CGGCTCACTG CAACCTCCGC CTCCTGGGTT CAAGTGCTTC TCACGATTCT CTTGTCCCAG CCTCTCTAAT AGCTCGGATT ACTGGCATGC ACCACCACGC CCACCTAATT TTGTATTTTT AGTAGACAAG GGGTTTCTCC ATGTTGGTCA GGGTGGTCTC AAACTCCTGA CCTCAGGTGA TCTGCCTGCC TTGGCCTCCC AAAGTGCTGG GATTACAGGT GTGAGCCACC ATGCCTGGCC CCAAATTTAT CTTTAATGCC CCAAATTATC TAGTTCCCAT GACTGGGCTT CTGCTTTGAT CCTTTCTGCA CTTGCTGGAC CCTCTCCCTG GGAAATGAGA TTGTGTCCTG AGCCCCTAGT TAGAGGCTAT GTCTCTGCTG TTCCTGAATG GGCCTCCTGG ATGAGACCTC ATTAAAAGTC TAATTCTCTT GGAGAATTGA GAGATACCTA TTTGTCTCAA AATCATTGAA ACCAATTAAT GTATTATGAG CCTCTATCCA GTGATTTGTA CCTCAATTCC CCAATCCAGC TGTCAAGGCC AATTTGTTCT ACCTTACCTA GTAGGTAAGT CTGGAATTGT AGCTGTGGCA TTTTCAGTAA TGGTACTCTA GGTTAGCAGT CCCCAACCTT TTTGGCACCA GGGACCAGTT TTGTGGAAGA CAATTTTTCC ATGAAGGGCT GGGCAGGGGA GTGGTTTCAG GATGAAACTG TTCCACCTCA GATCATCAGG CATTAGATTC TCACAAGGAG TGCGCAAGCT AGATCCCTCA CACATGCAGT TCACAATAGG GTGTGCACTC CCATGAGAAT CTAACACCGC TGCTGATCTG ACAGGAGACA GAGCTCAGGC AGTAATACTC ATTTGCCTAC CGCTCACCTC CTGCCGTGCA GCTCAGTTCC TAACAGGCCA CGGACCAGTA CTGGTCCACG GCGCAGGCAT CAGGGACCCC TGTTGCTAGG TATAAGCATC TGGCTGCTGC ATGTCTTCTG TGTAGCTACA TCTGTATGTG TATCTGATGA GATATAAATT ATTTGATTAT AAATTACTTT CTTCATATTA GACTTCTGAA TGAGTATCAC ATATAATTAT ACATAAACTA GGAATATGCT TTTTAATAAT GTATATAAGT AAGTTTCCTT AACTATGACT TTCATCTTAG CGTAGTAAGA GGGTGCTAAG AAATATTTGT GATGAAAATA GGCATTGGTA GAGTTGAGAC CACTGGGTGA TGAAAGAGTG TAAAGATTTT AAAGCCTTCA GATGCTGGTT CAAGGTGAGA AATGTGATTG GGAGCAAATC AATTAACTTC TTGAAGTCTT ATAGGGCAGT TATGAATACT TAATGTTAAC ATATGTAAAG CTCTTCTGCC CTGTATACAG TAAATGCTAG TTAGCTATTA TGATCACTAC TAAAATGGGG ATGACATAAA CCTCATAAGG TTTTAAGTAT TATGCAAGAT ACTATACAAA GTCCAGTAAA TATCACATTC AATTGAATCC ATGATGTCCG ATTATTTTAG CTACTTCCAA GAGAGAAAAA AATGCTGTCA GTTTTACTGT TCTTATAGAG AGCAAGGCAG ATCCCAATTC CCAATGTGGT AACGTGAAAA TTTTTGCATT TGAATCAACA AAACACTTTC TCCTTTCTTT CCTACTATTT AACAACTGGT AAGTCTATAC TCCCCCAAAT CTGGAATTCT CCTTTCTTAT TCTTTTTCCT CCTACCAAGA CCGCAGGATC TTTTACTTGG CTATAAGGGG TAAACCTCAA GTAGTACAAG TTCTCTGTAT TACTTTTATA CTCTGTCACA GATTCCCTTT GTTTCCTCAT CTCCATGTGA ATTTAGTTAA ATTCTCAGCA TTCTGATCCT TACTATACAA GGTAAATGAA TATAAAAACA AAACGAAACA AAAACCTCTT CCTATTTACA TAAGGCCCCA ACCTAATATT TAGTGATATA TATTAATGTG AACAAGGAAC TAACGAAGAC TGGGAAGAAA TTCACAGACT TGAGAGAAGA AATGGCAGGA TTTCCTGGGA ACAATTTCAT GTAACGTCAA AGGTGGTAAA AGGTCAAATA GAATGAAGAT GGAGAATACC GGATTTTCTT ACAAAATGAT TTCCCAGGAG ATCTCATCAA ATGCACGAGG ATACCTTCTC AGTTTCACCT AGTGAGTAAA AGACTGGTAA CATAGCTCAC TTACAATTTG GATAAACAAA ACTAAACAAA CAACATCAAA ATTTCAGAAA AAATAATAGC AAAACAGAAA TCAAACACTC AAATTTTTGG TCCTTCTGTT TATTTCATTT TGGATACTCA GTGAATGTTA ATTAACCAGG AAACTTAAAA GTTATTTCAA TTATGAACCT CTTCAATCCT TCATCAATTA TTTTGAGTAT TCTGGTCTTA AAAACATCTC TTTCTTCTAC AAACTTCTGA AAGAGATGAA CACCTCCACC TACACCAAAA TAATGTGCTT TGCTGGCCAA AAGTACACGT CCATTTTTAC TTAACAGTCT AAGGAAAGTC TGGTGCAAAT TACTATAATA ATCTGGGTTG TAAATGGTTT CTGAGGTGAG AATGAGATCA TATTTTACAA AAAGTTTTTC ACTACTTAGT ACAAGCTTAC AAAACTCAGA CCACTCACCA GAAAAAAATC GGCATTTATA TAGTTGTGTT ACTTTTGGTT TCCTGCATCT TTTCACATCT GGCTCATTTA CATCATTTTC TTCATCTTCC AAAGTGGAGT TAGCTACTAC ATTAGGTAAG GTTACTTCAT CAATCACCAT ACTGTTATAA TCTTGAAAGT GAATTTCTTT GGACCCTCCC TTGAATGCAG TTATACCTAG TAAACCTGAT CCACAACCAA GATCCAAGAC TTTTTTCCCA GCAAATTTCA CTTTGGCCTT TGTGAAATAA GCCAGGAGGT CAAAGGTACA TTCCCAGATT TTTAAGCCTC CCTCATAAAC ACCTGTAATC AGATCAGAGT GAGAAGAAAA GCTTTTTGAA ACTATGTTTT CTCCAGGGAA GTTCTCTTTC AACAAGATGG TTTTCACTAC TGATAACTTA ACATGCTGGA AACCTGGTAA TGTTTCTATG ACTTTATTTT CTAACATCTT CTTTAAATCT TTAGGCATAG CATGCTCTTT GGCAGCTCTC AAGGAGGGCT GTTTTCCATG TGGCTCCAAG TTCCTTGAAC TGCTGGCTGC ACTGAGTGGA CTGTCTGTGT CTTGAGAGGG AGCTGCATTT TCCATTGACT TATGTTCCCA CAAGTGATCC TGAGGCAAGT CAAATTGTTC TGCAGAACAT TTTCTGTCCC TCTCTTCTCC TTTTTGACTT TCTGAGACTG ACAGCTCTTT TGAGGAATCC AGGGTCAAAG CTCCATCTCT AATGGGTGTT AATTCATTTT CCAGATGGTC TTCTATAGTG AAATTAAACT GAAAGGTCAT CCTCTTATTA AATGCACACA ATCTTTAAAT TCAGATTCTT CAACTTCTGG ATAGAATTTG ATGATACACA CAAATCTGCC TCAATTATTC AATTAGTTTT GTTGGGCCCA ATTTCTCTTT AGCAGCTTAT ACATGGTAAC AAATATTTAG AGATATTTCC AAATGACTTT TTAGACGTCT TTGGTCCTCT TTCCAAGCAG CTCTGGAAAG AAAAAAAAAA AAAAAAGAAA GAAAATGATG ATTAAAGCAA AATGGCACAT TTCACTAAAG TGTAATATTA AACAGCCACC CCCACCCCTC CCTGTCCCAC CATACAGCTG CTTTTTCTTA AAAAGTTGTG GGGAAGAGAG AGAGATAAGA GATTTGGACA CTCATACACA CCTTAAGGGT TCCAAAGTGG GAGAAGAAAA TCAACTATAA AAACAAACAG AAGAACAACA GCAACCACCA CCACTACCAC CTGGACAAAC ATAAAGTCCA AGATATTCAG ACAGGACAGC CTAGCTACTT GCTGTCTTTC AGCTGTCTTG ATTTGTGTCC AACCATATTC ACCCCCTAAG CTTCCAGAAT AACTTCACTT CTGTCTTTTA CAGAAGAGGT GCAGTATTTT ATTTTGGTAA GTCAGCGTCC CTTTAAAAAC ATGCATAGGT ATGGCCTGGT GTGTGTAAAT TCATCCAAGA CTTCACTCCA AACATTTAGT CGAGAACAGC AGCCCTAAGT GTATAGAAGT GGGGGTAATT TGGCAATAAT TAGTAAAGAC TAATTCGGTG GCAGAGCAAA CGCAAACTAG GGCACTGCAG TAGTTTGGAG AGACCTGTAG AAATAAGAAG CAACTTTATT GAGAATCTTC TATCTACTGC GCTAGACACT ATACCATCTG CCTCAATTTT CACAGTTCTG GCAAGTGGGA TCTTTGTTCC CTTTATACAA GATTTACAAT TTGGGGGAGA GGCGGGTCAC CCAGTCCCGC GGCTAGGAAC GCGCCTCTTT CCTCTCCCAT CACGCTGCAA GGCTTGGAGT CACTTCCGGC TGCAGGTCCC GGAACAAATC CGACCCCAGA AGTGGGGACT TCTGGCCCTC ACCTCCCCAT TTGAATGTAA TGTTTACAGT GATCCAGACC TGGGGATGCT TGCTTCCCGA CGTGTCCTGG GATCGCGCTT CTGAAAAAGC TCACCTCACA ACGCCTCCTC CGGACCTAAA TCGCGCACCA GTGAGTCGAG TCCTCCAGGG GCTAGAGAAG CCCGACTTTC TTTCCGGCCT TGAGGGACCC GGGCTCACCA AGAAACCAGC CGCCCTCCTC TCTATGGTTT TGGAGCCGGC GGAGAGCGCG CAAGGGTTGG CGGGACTGCG AGTTTCCGGT CTGGGCTTTG GCGGGTCTGG TTTGAAGCTC TCCTGTTTGA CGAAAGTATG TCTCAGGAAG GTGCGGTCCC AGCTAGCGCG GTTCCCCTGG AAGAATTAAG TAGCTGGCCA GAGGAGCTAT GCCGCCGGGA ACTGCCGTCC GTCCTGCCCC GACTCCTCAT ATCCTTCCTT GGTTGTCACT TCTACCTAGA GAAGGGTGTG GGCGGGTCGC GAACCTTTCT CTTCTGTCCC TTCAGACCCA CCGCCAGGCT GGGTTATATT ACCGCGGCCT GAACCCCCTC TTTTCTTTGT CAGTGAGTGG GATGAAAAGT GAGGGACTGG AGGGGAAGCG ACAACCGTGG TAGATTTAAG TAAGGCTTTG GCCCTGGAAA GCCTCGCGGA CGTGTTCTGA CCCAAGGTTT TAGCAGTGGA TGTGGCGTTT TCTTCCATTC CTTCTTTCAG TTTTTCTGTA EPI-109 170

CTCGTTGCTT GCAATTAAGT GTAAATACTT TTGCTAGTGG ATAATGGGGG AGGCAAGGAC TGAGACCTGC GGTATGACGA TAGCTCTGGC TCTTAATAGT TTGAGGTAAA GCGAGATACT CTGAGCTTTT GTCTCCCGTA AAAAGGGTGG TGAATATGAA TAAGGGCTTT CTTAGCGTTA TAAGAATTAA AGGGCATAGT TCTGTGGTGT GAAATCTTTA AAAGATGTTC AGTAAATAAA AATGATTTTC CTCCTTCCCC TCTCAGACCT CTTTTTCTTC TTTCTTTCTT TTTTTTTGAC AAGTTCTCAC TCCTCTCACC CAGGCTGGAG TCTTTCTGAA AGAGTTCTTC CGCTTGTTGT TGGCTTTCAA CTGTTGGATT TGAGGCGCTT AGCGCCTTCT TCGTCCGGGT GCAGCACATT CTTGATTGGT CTCATGCCTT TGTGGTTGTA AATGTGCCTG GAATCCTAGC CTTTCATGGT AAACCATATG TATATGTATC TTTTTCACAA CATTTGAGCC CAGCTTTATA CAATTACACT CAAAAGAAAA AAAGTAACCT TCACTTGAGA GAATCTCAAT ACTGCACAAA TATTGTGCAG CTAAAGCCCT ATGTAATCAC ATAGAAGTCA TTCACCTAGG CATTAGCAAA ATCTCAGAAG GTGCCAAAGC CCCCTTTTTT AGTTTTTGTG TAGGTACAGA ACTGCCGTCT TCAAGGAGTT TCAACTTGAA AACAAATAGC CACCCTCAAA ACATTCAAAA ACACTTAAAC TGCGTGCATA ATGTGTGTGA GACATGGTGT TAGGCTTTGG GAGAACAGAG ACACGGAACG TGATTCCTCT TCTTCCCCAC AAGCTTATAG AGAGACTTCA TTAAGTTGAA AGTCAACATT CCCACCTAGC TTTGCACTTC AAACGACATA TTCAAAAAAG CCCAAACTTC CTCTAGTTTT CTTCATCTGA GTAAATGGTT TCACAAACTG AAACCTTGAA TCCTCTCTGT CTCACACACC CGATCAGTAA GTTCTATTGT TTCTGATTCC AAACTATGTC TTGAATCAAT CCGTTTATCT CCATCCTCAT TGCTACCACT CTGATTCCAA ACCCTTATCA CCTCTCACTT GGAGTATTAA TAGTTTCCTT GTTTCTACTC ATAATTCATT ATTCCAAAAA AGTTAAGAGG GGAAAAACAT AGATCTCGTC ATTTCCCTTT TTAAACCACT TTACCTTCAA GGTTCCAGGT GATCTAAGCC TTGCCCTTCT CTCATACCTA GTTAATTAAC TACACTCTGT TCATGAATAC ATTAGGCTCA CCTACCTCAA GATCTTTTTG CTCAGCCTGA TTTGTTCTCT CAGCCTTTTG CATATTTCAT GTTTATGTCT TGGCCCAAAT GTCACTTCCT TAGAGGGGCT TTTTCAGAGC CTTCAATCTT AGGCAGTTCC CCCAAACGCA GTCTTACACT TGTATCACAT TGGCCTGTTC AGTTTTCTAA AAAGCACATT ACCATTAAAA GAAATGCTCT TGTTTGCTTT GTATATTTTC CACTTCTACA CATTATGTTG CAAAGTTCAT AAAGGCAGGA TGTTGATTTT CTTCACAGCG TTACCCTCAG CACCTAGAAC AGTGCCTGAC ACATAGTAAG CATTCATTAA AGGGCTAAAA ATATTTCATG TTTTAAAAAT ACTTGGGAGT CTAATTAGAC AATACTTTTT TTCAGCTTAA TGGTAGTATT TTAGCTTCAC TATTTTAACA AATGAAAAAT TTGCAATAAA TCTACAATGC CATTACCCCC CAAAATCTTT TTCATGTTTT GCATTTTACG TATTATTTTC CAGGCCTTAC CTGCATGTCT GCATAATCAT AACTGACTAA TTTTGGAACA GCTGGTAATT ATTTGAGCTT TACTGAAATT TTTTCATGAG GCCAATTCTA CCCTACTGAA CTCAAATTTG AGTTAATGAT GACCTCATTT TGATTGCTGC TGTAAAAAAT AAGATTTCGG AAGAGGAATG AATTCTTGTA TTACTGTGGT AGGACTATGG GTTTTTTTTT GTTTGTTTGT TTGTTTTGAG ACGGAGTCTC ACCCTGTCAC CCAGGCTGGA GTGCAGTGGT GCGATCTCAG CTCACAGCAG CCAGGTTCAA GTGATTCTCC TTCCTCAGCC TCCCGAGTAG CTGAGATTAC AGGCACGTGC CACCATGCCC GGCTAATTTT TTGTATCTTT AGTAGAGATG GTTTCACCAT GTTGGCCAGG CTGGTCTCGA ACTCCTGACC TCGTGATCCG CCTGCCTCAG CCTCCCAAAG TGCTGGGACT ACAGGCGTGA GCCACCGTGC CCGGCCGGGT TATTCATTTT TCTTATTAAC ATTCTTTGAT GATTCTTATG GTGTTGTTAC AGTAAAACAT TTCTAACAAT TATTCTAACA ATTATTCTTG ATGGTGTATA TGAAGAATTT ATTGTCGTGT ATTTGTAAGC TGCTATGTGC AGAAGAATTT CAGTCAAATA AAGTTGGTAA GATAGGTATG TAAGTAATAT GAAAAAAGAT AGAAGGTGAT GAGTGACTTA GGTATAAATT AAGTACAATA GAAATGTTGA GGAAAGAAAA ATTTCTTGTA ATAGAAATCG GAAGTACAAA CTGGGCATGG TGGTGTGCAT CTCTAATCCC AGCTCCTTGA GAGGCTGGTA TGGGAGGATC ACTTTAGCCC AGGAGCTTGA GGCTGCAGTG AGGTGTGATC ATGTCACCGC ACTCCATCCT GGGTGACAGC AAGACCGTCT CTCTTTTTTT TTTTTTTTGA GACGGAGTCT CGCCTATGCT GGAGTGCAAT GGCGCGATCT TGGCTCACTG CAACCTCTGC CTCCCAGTTT CAAGTGATTC TCCTGCCTCA GCCTCCTGAG CAGCTGGGAT TACAGGTGTG CGCCACCATG CCCAGCTAAT TATTTTGTAT TTTAAGTAGA GACGGGTTCT CACCATACTG GCCAGGCTGG TCTTCAACTC CTGACCTCTT GTTCGCCCAT CTAGGTCTCC CAAAGTGCTG GGATTACAGG TGTGAGCCAC CCCACTTGGC CCCGAGCGAG ACCCTCTCTC TAAAAAAAAA TAAATAAATA AATCATAAAC CTGTGGATTA TTGTAGCATT GTTTCTCATC TGTCAAAAAT ATTTCATGAC TATGCATAGT TTGAAAAGGC AAGTTTGTCC CTGGGCAATT TTCAAAATAT TTCTTTAATG TGTTTTCACA ATACTGTTTA CCTAATAAAT CTTAAGTTTT TAAAAGCAAA ATTAAGCCAG TAATTTGAGT CCAATTCCAA TCTCTTATGA GTCATTGCTT AAATTTCAAA AGGGTTTTAT TTTTTTTTTA GGTTTGTTCT GAGTAATGAA TACCCTATTA CTATGATACT AGTATCTTCC TTAATTATCC TACTCATTGT CTCAACATTC TGACAGTTGG ATTGAGCATA TTCGTAAGTA AAATTGTTTT AACTGTATGA TGTACTTTGA TGTTAAGGTC CGAGTCCCCA CATACCTCGG TAGATGTGTT CTTACAGTTT TGTATTCCCT TGAAATGTAA CTGTTCTCTA TGTTACAGCC TTTATAACCT TCAGTTACTT GAAATGAACA AATTCATTCA AATTCCAGCA CTTAAAAGTT TTAAATTACA TTTTGGATAA ATACCAAAGT GTTTTGTTGA TGATGTATGT ATAAACAAAT TGTAAATATT AAACGTTAGT TGTTACGATT AGACCTATAT AAAACATGAT ATGCAGTCTA CTGAATAGCT ATCAGCCTCT AACATGTTTA GTGTCATTTA GAAAATGCTT TCTAAATTGC CAAAAGCTGA TTGTCTAGGT GATAACAAAT TTACCATTTG GAGGAAGTTG ACTTTCTCAT TTTCATGTCT TCATCAGTCT TACTTGATGA GATTCATTCT TCTAGTCAGA AGAGAGTTTA GACTGCTCAG TTTACTCATA TTTTGAGTTA GCTTTTCTAT TTAGAGTTCA CTTGGTTGTG GAATATTCAT TTATAATTTG AATCTACGTT GTGTAATGGG ACCTAATTTT TTTTTCCTTT GTTTTTGTTG GAGTCTCGTT TTGTCACCCA GGTTGGAGTG CAGTGGCGTG ATCTTTGCTC ACTGCAACCT CCACCTTCCA GGTTCAGGTG ATTCTCCTGC CTCAGTCTCC CAAGTAGCTG GGATTACAGG CATGCTTCAC CACGCCTGGC TAATTTTTGT ATTTTTAGTA GAGATGGGGT TTCACCATGT TGGCCAGGCT GGTCTCAAAA CTCCTGAGCT CAAGTGATCC TCCTGCCTTG GCCTCCATAA GTGCTGGGAT TACAGGCGTG AGCCGCTGAG CCTGGCCCCA GAGTTTGTTT TGTTTTGTTT TCAAGACAAG ATCTCACTCT ATTGCCCAGG CTGGAGAGCA GTAGTGCGAT CATAGCTCAC TGCAGCCTGA ACTCCTGGGT TCAAGCTATT CTCCTGCCTC CATCTTCTAA AGTGCTGTGA TTACAGGTCT GAGCCATGAT GCTTGGCCTG TGTTTTTGTT TGTTTGTTTT GGGGGACAGG GTCTTGCTTT GTCACCAAAA CTGGAGTGTA GTGGTGCGAA CATAGCTAGC TCACTGCAGC CTCCATCTCC CACGCTCAAG CAATCCTCTC ACCTCAGCCT TCCAAGTAGC TGAGACCGCA GGTGCGTGCT ACCATGCGTG GCTAATTTTC TATTTATATA TTTATTTTTT GGTAGACATG AGGTCTTGTC ATGTTTCCCA GGTGGTCTTT AACTCCTGGG CTCAGACAGT CCTCCCGCCT CAGCCACCCA AAGTGTTGGG ATTACAGGCG TGAGCCACCA TGCGTGGCAT AATTTTTTTT AAGTAAATTA TTTTTTTATC TTGAGTATAG AAGTGATTCA TGTTCATTGT GGAAAATATG AAACATATAG AAAAACAGAA AAGATTACAA AACATCTAAT CTGAAATGGT TAAGATTTTG ATGAGAACAG TCTCATCTCA TTTCCGTATA TTCCTGCCAG CCTATCCATC ATTCTTCGTA CATGTTTATC TACATTAAAA TTGGTGTTAT ATTTTGGAAA CTTTTTGTTT AACTACATTG TGAACATTTT TCATGTTTTA AAATGTCATT TTAATGATGG CAGATCCTAT TCAATAGATG TACACACACC TATTTAACTG GTCCACAATT GTTGGATATG TAGGTCGTTT CCTTTCTCTC TTTTTTTTTT TTTTTGGCTA CTACTTAATA GTTTCTCTGT ATAGAATGTG GTATTTTGAA AGTGTATCAA GCTTTAGATT GGTAGTATTC TTGCATTTAA TAAAGGGCAG TGGCCTTTGT TGACTGACAT GACAATATTT TTATAAAATT TGTTATTTGC TTTACAGAAA TTTTGAAAAT TATTGTAGAA ATGTTTTTAC CTCATATGAA CCACCTGACA TTGGAACAGA CTTTCTTTTC ACAAGTGTTA CCAAAGGTAT AATACTATTA CCTGAAAATA CATGTTATAA GGAATCTAGC CTCAGTCTTA GATGATTTAT TATTAATTAT GGCTCTCTTT TTCTAATATA TCAAATATAT TCAAAATAAA AATAAGGAGT AAGTAGATCT CATGTGAGAC TATAATGGTG TTAGTGTGAT CATTAGGCAG TTAAAAACTG TTACAGGCTG GGCACGGTGG CTCATGCCTG TAATCCCAGC TCTCTGAGAG GCTGAGGTGG GCAGATCATC TGAGGTCAGG AGTTCGAGAC CACCCATGGT CAACATGATG AAACCTCGTC TCTACTAAAA GTACAAAAAA TTAGCTGGAC ATGGTGGCAG GTGCCTGTAA TCCCAGCTAC TTGGGAGACT GAGACAGGAG AATTGCTTGA GCCTGGGAGG CGGAGGTTGC ATTGAGTCAA GATCGTGCCA TTGCACTCCA GCCTGGGCAA TAAGAGCGAT GCTCCGTCTC AAAAAAAAAA AAAAAAAAAA AAGAACTTAT ATTTTCAGAT TGTGTGGTTC CTTTACTAAC TGAATTTAAA TTATTTGTAG TCAATTTTAA ATGCTCTTGT ATTTTAAAGC CACTGTACTC CAGCCTGGGT GACAGAGTGA EPI-109 171

AACCCTTAAT TCAAAAAAAA AAAAAAAAAA AAGAAAAGCT GGAATATTGG CAAAATCAAG TAACTAAGAG AAAACATTAA ATTCACAGAA TACATTATTA CATTTTAGAT ATATATGGTA TATGTTTTCT CTGAAAAGCA CAAGCATACC TTTTTTGTTT TAAATGGAGG GAACTAAAGA TACTTTGGTG CCAAAATGAA ACATTATTTG TAATTAATCT CTTATTGAAA TGGGTTTCTA ACTTTAGCTT TGAATCGTAA TCTTTCAAAT TTCTTGTACT CATAGTCACT TGATGATTCT CTATCTGAAA TATTTCTTAG AATTTGTTCT TGACCACCAG AAAAAGATTC AACTGTTACA TAGATGAAAA TGGATGTTGA GTGTTAACAG GCCTATGGGA AACAGTATTT TCTTTAGCTA CATTGTATTG TTGACTGTGT TGCTATTCTT ATAATGTTTA GGTCATTTAA ATTGTTAGAA AGATCCAAGT ATTAAGATCT AGGGTGGCTA ACTTTTCACA GACAAAAAGC TTGTTTGTAA GGTCATTTAC TATACCCTTA ATTCAGGAAG GTTAGCTTGA ATTGGGTCAA AAGGAAACTG GTTAGAAAAT AAGTGAGTAG TGAATAGGCG ATTCAGTGCA AATTCCTTCC AGAAAATACC CTTGTAAATG ACTGTATGAA TGTGGATTCT TCAAGACAGT CAAATTTATT GTGCGAAAGT AATACTTTTA TTTTTTGCAT CTCTAAAACA TGAACTTTGA GTGATTTTTT AAAAAAATTG ATGCTATTAA ATAGATTCAA ACCATAGAAA TGGAAAATAA ATTTCTGTTT GGGGCTTTTG GGGGGATTAT GTTGTAAAAA TACCTTTTCT CTGTATTTTG TGCTTAATTA GGTACAATTG TTAAGCTAGA TGATAGCCTG TGGATGTTAC TAGTGCAAAA TCAAATTATC GTATTGTGTT TTCTCTGTAA AGTTTTGTCT TGTCTTTTCT AGTGATTTCT CTTATTCCTG TTTATTACTT GATTTGTTTT TACAGACTGT GAAATTATTC GATGACATGA TGTATGAATT AACCAGTCAA GCCAGAGGAC TGTCAAGCCA AAATTTGGAA ATCCAGACCA CTCTAAGGAA TATTTTACAA GTAAGTCAAA TGTATTAGAA AGCAGGAGAG AGAGGGAGCT TAAAGAATGT CAAAATTTTT ATACTGATAC TGATTAGCTA TGTATTCTTA TGTAATGGCC TAATGTTGGA ATTAAATTTA TAGAATTAAA GACGTGAATA TAGAAACATG AATTCTGAAT AATAAACTCT TATAAGAAGA GAAGTCATCA AGCTAGCTGA CCCTACCTGT ATTTTCAAGG ATATGTGTGG AACACCTGCC ATGTGTTTTG AAGTTTGTGT TAGTATTCTA AATGGCTAGA CAGTTGTTCC AGTATTTGTA GTTCTGATAG ACTAAAGTTC TGTGAAAAGA GGAAGAGACT GTGTTTTGTT CATTGCTGTA TTTGTAGCAC CCAGCATGCT GACTAATACC TTTTCAGTGC ACAAAAAATA TATTCTAAGT GAAATTTCCT TCCTTATTCA CAGACAATGG TGCAGCTCTT AGGAGCTCTC ACAGGATGTG TTCAGCATAT CTGTGCCACA CAGGAATCCA TCATTTTGGA AAATATTCAG AGTCTCCCCT CCTCAGTCCT TCATATAATT AAAAGCACAT TTGTGCATTG TAAGGTGAGT AAAGGTCTAA TTATACTTTG AATGGTATAT AATCAATGTG CATAGGGGCT GAGTAAAATA ATGTTTGTAT AAGATTTTAC ATTTTAGTCT ATATTATTGA AATAAACTTT TCCATAGAAT AAAGAACATG TAAGTAAATA ATTGTTGCAA AAAAAGTGGT TTTAAGGAAG TCATTAAAAG TGGCTTTTTG GGGTTTTTTA GTTTTATCTT ATTTCCCCTC TATAAAGAAA GAAGTTTTAA GAATTTGTGT TGAGACAGAC ACAGGGATCC TGAAATAGTT ATGTCATGTT GCATTGACCA ATATTCAATT ACCATTATGA TTAGATGTCA GAACTTCCTT TTATAAAGGA AAGTTAATCC TTATTTAGTC CATCTCTACA TGCCAGAGGT AGCCTTGAGG CACAAAAGCT TGCCTAGAAT TTATGGGTCA CAGACAGTTT TAATATTGCT ATTTGTTGGG CGAATGAAAA TCACTAGTTA ATTAATACCT CTCTTTGCTG ATAGGATGCT AAAAATGTCA CGCACCTGGC CTAATGTTAC CCTTTTTTAG TTCTGTATTT GCAAGATCAT GGAAGTCAGA AATAATATTT TATACATGCT TGCATCTCTT GAAGCACACT ATATTTAATG GATGTTCACT AAACAATGAA TGAATATGTG ATTCAGTAAA TTTATGATCT CTAATAGTAT GAATTAAAGT AAATTTGGCT CTTGAGCTTT GATTTGTTTT TTCTCTCATT TTTATTTATC CGTAATCAGA ATAGTGAATC TGTGTATTCT GGGTGTTTAC ACCTAGTTTC AGACCTTCTC CAGGCTCTTT TCAAGGAGGC CTATTCTCTT CAAAAGCAGT TAATGGAACT GCTGGACATG GTTTGCATGG ACCCTTTAGT AGATGACAAT GATGATATTT TGAATATGGT AATAGGTGAG TGAAGAAAAC TTTCTGCTTA GTATATGGTG ACTATAAATC ATGTATCAAT TAAAATTGTC TCTAATGATT CATGTTATTT TCTTACTAAT TATGCATTAA AATTGATTTA AATCTTACCA AATAAATTTT TAATCTTGAA ATTTGGAATT TGTAAAATTT ATTTTGGGTA CCTTAACCTA GATTTGCGTA TTTAGTTACT GTAATTTCTC CACAATGATT AACTTATATA ACTTTATAAT CTCTGAGGTT GTCCATATTC AGAGACAATA ACTTTCACAT TTTTTTAACC ATAACTGATA TTGAGATGCA GTTTATATTT CCTTCCAGAA TACATATAAA TACGTGCATA TGTGTATGTA AATATGTCTA TTCTCATATA CATATTATAA TGAAATAACT CATTTTACAT GTGATGCACT TTATACTAGT TTATTTTTAT TTTATTTTAT TTTTTTGAGA CAGAGTCTCA CTGTGTAGCC CAGGCTGGAG TGCAGTGGCA CAATCTCGGC TCACTGCAAC CTCGCCTCCC GGACTCAAGC GATTCTCCTG CCTCAGCCTC ATGAGTAGCT GGGATTATAG GCGTCCGCCA CCACACCTGG CTAATTTTTG TATTTTTAGT AGAGACAGGG TTTCACCGTG TTGGCCAGGC TGGTCTTGAA CTCCTGACCT CAGGTAATCC ACCTGCCTCA GCCTCCCAAA GTGCTGGGAT TACAGGCATG AGCCACCGTG CCCAGCCAAT ACTAGTTTAT TTTTAAAGAA TTGCTGGTCG TAACACACTT CATTGATTTT ATCACTCATT AATGGATTAT GAACAAGAGT TTGAAAAACA ATATAAAGGC AAAGTTTGCA TTCAAAACTT TGGTATAAAG AGAGTAAGTT GGTTTTGTGC AGTGTATCAG GCACCTGTTG CTCTGCAACA CACCACCTCA AAATCTATTT ATTCACTATT TATTTATTCA TGATTCTGTG AGTCTGCAGT TTAGGGTGGG ATGTCCTGAG ACAACTTTCT CTGATCCACC TGGGGCACTA GCTCACCCAT GTGACTTCAG TGACTTCATT CACATCTGGC TGTTGGCAGA GGCAGAAGTA CTTGAGAAAG CCATGTGCAT CATCCAGCAG GTTCACCCTA TCTCAGATAC CTGATGCCAG TGGTTTCAGG GTTTCTAAGA GTAGCAAAAG TGTGAGCAGG TCGCTGTGTG CTAGCACTTT TCAAGTTTCT GCTTGCCTTA ATTTTATTAT TGTCCCCCGG GCCACAGCAG GTCATAGCGT TTAGCCCAGA GTCATTGTAG AAAAGTGTGG ATTCACAAAG GGCAGTCATT GTGGCCATTT TTATAAATAA TCTACCACAG ACTGAGTAAA AGCCTTGCAT GAATACCATG GATATTAATT TGAATTCTTC CTTTTTAGAT TTTCTTTCCT TAGCAATTTG TTTTGTCATT TTGGATTAGA ATTATATCTC TAGAATATTT CAGTTATAAT AGGGTACAAC TTTTATTCCA CTGAACATCT TTAGTTTTAT TTAGGTCATC TGGTAGGTAT AAACTTCAGA AGTTAATATT CAATATTTAT AAAAACCATT AACAAGTGTG ACACTTAAAT AGTTTAAATA ATTCTTTTGA CACAACTGTT TCCAAGTTGT GTTACGTATT TTAATTCAAT CAAATGTTGA AATTGTTCAG TAGATAGTTT TAATTATAGG AGAAACTCAC CCCCATGACA TTTGGATGTC TTAAAAGTTC TGTTATCTTT CTTTGCAGTT ATTCATTCTT TATTGGATAT CTGCTCTGTT ATTTCCAGTA TGGACCATGC ATTTCATGCC AATACTTGGA AGTTTATAAT TAAGTAAGTT TGTTTGTTAT TTTTTACTTT TTAGAAAATG TTTTCCATAT TCCCCAATCT TAATTATTCA TGATTCTTTA GATTGCATTT AAAACATTTT GTGTGAATTT AATGTTCACT GACACTGCTG TCTGATAATC CAGATATTCT ACATGTAGCT CTCAAGCCAA ATTGGACTTC TTTACCCTGT GGCCTCTAAA ATTAAAAAAA ATGTTCTTCC TAGTTAGCTA GTACTTCAGA AATAATGGGC CATGGGCCAG ACTAGAACTT AACCACTTTT CTTCTGCTAC TGTTGTTTAA CCAGCTATCA AGTATCCTAT TTCTAGGATT AGATAAATTG ATAACTATAA TTAAAACTGA ATATAATCTT TTCATTAGGT ACTTTTAAGT TGTTCACACT TAATTCCATT TGTACAGTAA TΠTAACTTT CTGAAACTGA AGCATTTTAA AGGGTCACCA GGGATAGTGC CTGTAGCATT CATCAGATTC TTAGGGGTGA GAGGAGATGT GGTTGAGATG TAAAAATGGT TAAGAATATC TACTTTATAC ACATACATAA AACATTAAAG GTCAGTGTAT TTTCAGGTCT TAGGTACTTT TCTTGTACTA CCAGGACATT AAGTTGCCAT TCAGTGGTTA AGAGTGTTGC CTGGGAGCTG TATCACATGT GCTTAAATCC ATTCTTGAAA TCATTTACTC CTTCTGAGCC CTTGGGCTAT TTGGTTAATT TCTCTGAACG TTAGTTTGCT CATCTGAAAA TGGAAATAAT AATAGCAACT TCTTGACAGG GTTATAGTGA GAATTGAGTT CATCACTGTG AAATGCTTAG AAATGTGCAT GACACATAGT TAATACTCAA GGAATTAGCC ACATCACTAT CATCATCACT GATTATCTTC CACTCTTACC CTCTTCCAGT TCATTTTCTG CCCAGCAGAA TGATCTTTTA AAAAGTAAAT CAGATCATGT TACTCTATTG CTTGAAGTCT ATCCCATTTG ATTAAGAATA ACAACCTAAT CCTCTGTGGA TGCTGCCTCC TTCACCAGCC TGTCTCATGC TGCTCTCCCT ACTCTTAGTT CCTCAAACAT ACCAAACTCT CCTGTCCCAG AGTCTTTTCG TGGTTTTTCC ATCTGCCTAG GATGCTTCTC TCTCCTATTT TGTGTACCTT GCTAACTCCT GCTTACTGTC TTTCAGTTCT CAGCTTAAGA GTTATATCTT CATGATAACA TTCTTTGATA TCCTTACCCT AAGATTAAGT TAGATTGATA TCCTTACCCT AAGAATAAGT TAGATTAGGT CTCTCTATTG TAGCACCTTA GACTCTGTCA TTTGACAAAT CACAGCCCTA ATTAATTATT CTTAAAATTA TTTAACATTC TCTCTCATGC TAGACCACAA GTTTCATGCA GGTAAGGCGG AGATTGTGTC CATTTGTTTG ACCCCTTTGT CTCCAGGGCC TGGTAGAATG CCTCATACAT AGTAAGAATT CAATTAATAT TTTACACAGA GAAAAAATTA GCAACTTATT TAAACAAATA TAACTGCTTC AGAGGTAAAC TGGGCACATC TTAGTTATAT EPI-109 172

TATGTGATAT ATGATGCTTT TTGATTGTTT TTTTAAATGT TCTACAAGGT AGATATTGTT AGAGGTCCTA AGTTACTTGA TGTGTTACTT GTGGTGATTG TATTCTTTTC TTTTTATTCA TTTAGGCAGA GCCTTAAGCA CCAGTCCATA ATAAAAAGCC AGTTGAAACA CAAAGATATA ATTACTAGCT TGTGTGAAGA CATTCTTTTC TCCTTCCATT CTTGTTTACA GTTAGCTGAG CAGATGACAC AGTCAGATGC ACAGGTAAAA TTTGGGCTAA TAGCATTTTA AACAGCAACT CTTATTTTCT TTGGCAGTTA GTAAATCTCA TTTGAATGTC TGGGTCAGTC TATTTAAGAG GATTTTAATT TATTTCATTT GGGTGTTTTT TTTTGATCTG TGGGATTATT TATATCCCAT AATTACTTTT CACCCAGAGC ATTGTATTAG ATTCCTAACT GCTGTCATTG CCTCTGGGGT CTGCCTGGCT CCCTCTTTGC TTGGTAACTG GTTGGTCACA GCATTCTTCT CAGAATCCTT TCATTCTTTT CTGCATGAGA ACAAAAATTC TTTTGTTCAT ATTTGTATAA GATCTGATAT AGCTGCAATC AATCTTGCAT TTTTTCTTCA CCAACGCATT GCGACCTTTA GGGATACAAG TATGTTTGTG CATGTATATG TATGTATCAG TCTTTTAAAT TTGATATAGT CATACATTTG TTTTTATTTT GAAAAGTTAG AGTGTTGAAT TGGTATCCCA TTTATGAAAC ATTATATTCT AAAAATTTGT AGTACGATTA TTGGGAATTA TAACTCATTT TCCTGTAACA CTGTTATACA TAGTACCTTT TGCTTTCAGA CTAGCCCTCA ATTTTATTTA ACTATAGTAG TCCTAAATTA TAAGATTAAT AGTACTCAGG ACCTAACAGT TATATGTCAT TTGTTTTTTT TTTTTTTGAG ATGGCGTCTC ACTCTGTCAC CCAAGCTGGA GTGCAGTGGT ATGACCTTGG CTCACTGCAG CCTCTGCCTC ACGGGTTCAA GGGATCGTTC TGCCTTAGCC TCCTGAGTAG CTGGGATTAT AGGCGCCTGC CACCACGCCT GGCTAATTTT TTTAGTAGAG ACGGGGTTTC GCCATGTTGG CCAGGCTGGT CTCGAACTCC TGACCTCAGG TGGTCCACCC GCCTTGGCCT CCCAAAGTGC TGGGATTACA GGTGTGAGCC ACCGCGCCCA GCCTATATGT AATAATTTTA ATGGGACCAT GAATTGAATA TTTCTTCCTT GAATAGCAAT GACATAGCCC CTTCTATTGT ACATCTGCAA GCTGATACAG GGAATTCCTT TGTACCTGCG CTCTTCCCTG CCAGTCAGCT ATGGGGGTGA AAGTGTAGGG GTTCATCCAA GTCCTAAAAC TGGTAGCAAC TCCTAGGGCA GGGCTGATCT GGAAGGACAG ACCCTAGGGG AGGGTGGAAC TTTAAAAAGA AGTTCTGAAG GTAGTAAGAA GGAAATGAGG AGTAGTGTTA GGAAGGGGCT AACTTTTTTC TTCTTGCTTC TCTTCTTTAT CTCACCTGCC CCTCCCCTTG TATCCCTTCT TCCTTTTTCC CTTTCCTTTT TTGTCCTCAC TTCATTCGTG CATCCTTTCT GATTCCTCTT ACCTTGCTAA AAGGAGAAGT TTGTTTGGGT ATCCTATATC AATGGCAGGA AGGTTGTTTT CTTCTTTACC TTTATCCTAT AGATTCATAT TCTCAACACC AACCTCCTCC TTTTTCAGTT TCCTTCTTGC TTCTCTTGAC ACCACAGAGT TTGCAGCTAG TACTTGGAGA GGAAAATTAA ACAGAGATAC TTGGACCAAG AGTAAGATGA AGAAAGTCTA AACAACAGTA TAGTCTATAG TGGCAAGAGA GAGTATGGGG GCTGCTTAGC CAGGGTGGCT GTACATAAAG TATATCTTCA GTTTATATAA ACTGCTTATA GATGGAAATC AGAAAATTTA AATTCTCTTA ACTGTCCAAG AAAATTCTCA TTTTTTCAAA TTTGGGACTG ATAAATGTGA CCAGTTCTGC TTACTGTCCA TTGCCTGAAA TGGAGCTTTG AGGTGGACTG TATAATTTCT TCAATCTTAA CTCCAAATTC TGATCAGCGA CGCCCTCTGC TGTTCACTAT TAATATTTAT TTACCAATCA AAGTAAAGTA TTGAAGTTTT CCTGGCAGTT TTCACTTTCT GTTTTAGTCC ATTTAGGCTG CTATAACAAA ATCCCTTAAA CTGGGTAAGG GATTATAAAT ATTAGAAATT TATCTCTCAC AGTTCTGGAA GCTGGGAAGC CCAATATCAA GGCACCAGTA GATTTGGTGT CTAACGAGGG TGTGCCGTCT GCTTCAAAAA TGGCCCCTTG TTGCTGCATC CTCACTTAGT GCAAGGGGCA AGACAGCTCC CTTCAACCTC TTTTATAAGG GCACTTATGT CATTCATGAG GGCAGAGCCC TCATGACTTA ATCACTTCCC CAAAGGCCCC ACCTCTTAAT AGTATCACAT TGGGTGTTAG GTGTCTGGGA GGACACCAAT CTTCAAGCCA TATCATCTCA CTTGGAAAAA AGTCAAAATA AAACCAGTAG ATTTAATTAA TATTACACTA TTTATAGAAG CATGTGATGT ATCATTCCTT GTATTAATTT CCTGGGGTTG CCGTAACAAG TTACCACAAA CTAGGTGGCT TAAAACAATA GAATTTTATT CTCTCACATT TCTAGAGGCA GAAGTTCACA GTGTGTCAAT AGGGCCATGT TCTCTGGAAG GCTTTAGGGG AGAATATATT TCATATCTTT CTCTTAGCTT CTCGGTGTCA CTGGCAATCC TTAGCTTACT TTGGCTTTCT GTGTCTTCAC ATCATCTTTT TATAAGAACA CCAGTGATAG TGATTAAGGG CATACCTTAC TTTAATATGA CCTCATCTTA ACTAATTATG TCTTCAATAA CCCTATTTCC AAATAAGGCC ACATTCTGAA GTATTGGGAG TTAGAACTTA AAGCTTTTTG GGAGGGACAC AGTTCAACCC ATAACAACCC CTAAAATCGA TATTTATTCT CAATTAAGTC TTGAAATTGG TTTCAAAAAG AGAATATTCT ATTAGAGTTT TTAATGTATA GTTTTAACAT ATAGTTCTTT AGCCCCCAAT TTTTTTTTTT TTTTTTTTTT TTTTTTTTTT TTTTTGAGAC GGAGTCTCGC TCTGTCGCCC AGGCCGGACT GCGGACTGCA GTGGCGCAAT CTCGGCTCAC TGCAAGCTCC GCTTCCCGGG TTCACGCCAT TCCCCTGCCT CAGCCTCCCG AGTAGCTGGG ACTACAGGCG CCTGCCACCG CGCCCGGCTA ATTTTTTTGT ATTTTTAGTA GAGACGGGGT TTCACCTTGT TAGCCAGGAT GGTCTCGATC TCCTGACCTC ATGATCCACC CGCCTCGGCC TCCCAAAGTG CTGGGATTAC AGGCGTGAGC CACCGCGCCC GGCCTGCCCC CAATTATTTA GTTTTTCTAT AAACAGGGAA ATTTATTTGT GTGGCCCTTA GAACTAATTT AATTTCCACT CTAATTCCTA CTTATGTTTA TATAATGCTT TTAGAAATTT GTATTATTCA GAAAATAAAC ATATACTATT GTATCTGTTG CCTACACTTA GATTTTATTG CCTGCTATAT TTAAATTTTA TTAGTATTTT AATTGTTTTA TTAAAGAAAG AATGTGCCTG TAATCTCAGC ACTTTTGAGA GGCCAAGGCA GAAGGATTGC TTGAGCCCAG GAGTTTGAGA CCAGACTGAG CAACACAGGG AGACCCCCAT CTCTACAAAA AATAAAAAAA TTCTCCAGGC CTCATGGCAC ATACCTGTAG TTCTAGTTAC TTGGGAGACT GGGGTGGGAG GATGCATTGA GCCCAGGAGA TTGAGGCTGC AGTGAGCCAT GATCAGGCCA CTGTACTCCA GCTTGGACAA CAGAGTGAGA GCTTGTCTAG ATAGATAGAT AGATAGATAA TCTAAATAGA TAATAGACAG ATTATCTAAA TAGATAATAG ACAGATTATC TAAATAGATA ATAGACAGAT TATCTAAATA GATAATAGAC AGATTATCTA AATAGATAAT AGACAGATTA TCTAAATAGA TAATAGACAG ATTATCTATC TAAATAGATA ATAGATTATC TAAATAGATA ATAGATAGAT AGATTAGATA GATAGATAGA TAGATAGAGC TTGGACAACA GAGTGAGAGC CTGTCTAGAT AGATAGAAAC AAAGAAAGAA AGAAAGAATG GTGCTCATAT TTTAAAGCAT TGAAAAATGG TCTTCCTTGC TTATATTACC CACACCTTCT TTGTTGGCAT TAAGATGCAA ACTTTGTTTT AAACAGTTGA GTAAATCAAA GATGGGACTG TTAAGTTATT TGTGTTATTT ACCTGCTTTT TGAAAATGTA AAAATAAAAC TCTAGGTTTA ATTAGTAGTA TGCTATTTAG TAATGAAGTA AAGCTAGAGG CTTCGAACAA ATCTTGTGTA ATTTCCTCTT GAATGAGAGA GAAAATTTAA AGTAAGCAAA CAAATAAGTT GTGTGTCACC ACTCATTCAG TCATTTAACA AGTATTTCCA GAGTACTTAT TCTGTGCCAG GAAATGTTGT AGGTGCCCTC AACAACTTAG AGTCTAGCCT GAGACACAAG TAAGTAGGTA ATTATTATAG AATGGTATGA TCTTTGGAGG ACTGGGTATT GGCTGGCTCA TGGGAGTACA AGATAGGTAC CCAGTGATGA AGTCAGGAAA GGTTTCTTAT GGTGATATGA TGACGTCTAT GCTGATTATA AGGTCAGTGT AGAATAAACT TTGTGCTTTT AAATTTGCAT AGCACTGTAT TAGAGAGTTC ATCTTCAAAA TAATCGAAAA GGCTGAGTGT GGTGACCCAT GGCTGTAATC CCAGCACTTT GGGAGGCCGA GGTGGGCAGA TTGCTTGAGC TAGGAGTTCG AGACCAGGCT GGCCAACATG GTGAAACCCC GTCTCTACTA AAAATACAAA AATTAGCCAG GAGTGATGGT GCGCACCTGT AATGCCAGCT ACTTGGGAGG CTGAGGCAGG AGGATCACTT GAACCCAGGA GGTGGAGGTT GAAGTAAGCC GAGGTCATGC CACTGCACTC CAGCCTGGGC AACAGAGTGA GACTCCATCT CAAAAAAAAA AAAAATGATC AAAGAAAGGT GAATTTTCAT CTACCCTATT TCTGCTGAGG AAAATGGACT ATTTTCAAAT ATTTTTAATA

AGGGTCAAAA TGAGGGATC-3' (FRAG. NO: ) (SEQ. ID NO: 2480)

5'-CCTGAGACAG AGGCAGCAGT GATACCCACC TGAGAGATCC TGTGTTTGAA CAACTGCTTC CCAAAACGGA AAGTATTTCA AGCCTAAACC TTTGGGTGAA AAGAACTCTT GAAGTCATGA TTGCTTCACA GTTTCTCTCA GCTCTCACTT TGGTGCTTCT CATTAAAGAG AGTGGAGCCT GGTCTTACAA CACCTCCACG GAAGCTATGA CTTATGATGA GGCCAGTGCT TATTGTCAGC AAAGGTACAC ACACCTGGTT GCAATTCAAA ACAAAGAAGA GATTGAGTAC CTAAACTCCA TATTGAGCTA TTCACCAAGT TATTACTGGA TTGGAATCAG AAAAGTCAAC AATGTGTGGG TCTGGGTAGG AACCCAGAAA CCTCTGACAG AAGAAGCCAA GAACTGGGCT CCAGGTGAAC CCAACAATAG GCAAAAAGAT GAGGACTGCG TGGAGATCTA CATCAAGAGA GAAAAAGATG TGGGCATGTG GAATGATGAG AGGTGCAGCA AGAAGAAGCT TGCCCTATGC TACACAGCTG CCTGTACCAA TACATCCTGC AGTGGCCACG GTGAATGTGT AGAGACCATC AATAATTACA CTTGCAAGTG TGACCCTGGC TTCAGTGGAC EPI-109 173

TCAAGTGTGA GCAAATTGTG AACTGTACAG CCCTGGAATC CCCTGAGCAT GGAAGCCTGG TTTGCAGTCA CCCACTGGGA AACTTCAGCT ACAATTCTTC CTGCTCTATC AGCTGTGATA GGGGTTACCT GCCAAGCAGC ATGGAGACCA TGCAGTGTAT GTCCTCTGGA GAATGGAGTG CTCCTATTCC AGCCTGCAAT GTGGTTGAGT GTGATGCTGT GACAAATCCA GCCAATGGGT TCGTGGAATG TTTCCAAAAC CCTGGAAGCT TCCCATGGAA CACAACCTGT ACATTTGACT GTGAAGAAGG ATTTGAACTA ATGGGAGCCC AGAGCCTTCA GTGTACCTCA TCTGGGAATT GGGACAACGA GAAGCCAACG TGTAAAGCTG TGACATGCAG GGCCGTCCGC CAGCCTCAGA ATGGCTCTGT GAGGTGCAGC CATTCCCCTG CTGGAGAGTT CACCTTCAAA TCATCCTGCA ACTTCACCTG TGAGGAAGGC TTCATGTTGC AGGGACCAGC CCAGGTTGAA TGCACCACTC AAGGGCAGTG GACACAGCAA ATCCCAGTTT GTGAAGCTTT CCAGTGCACA GCCTTGTCCA ACCCCGAGCG AGGCTACATG AATTGTCTTC CTAGTGCTTC TGGCAGTTTC CGTTATGGGT CCAGCTGTGA GTTCTCCTGT GAGCAGGGTT TTGTGTTGAA GGGATCCAAA AGGCTCCAAT GTGGCCCCAC AGGGGAGTGG GACAACGAGA AGCCCACATG TGAAGCTGTG AGATGCGATG CTGTCCACCA GCCCCCGAAG GGTTTGGTGA GGTGTGCTCA TTCCCCTATT GGAGAATTCA CCTACAAGTC CTCTTGTGCC TTCAGCTGTG AGGAGGGATT TGAATTATAT GGATCAACTC AACTTGAGTG CACATCTCAG GGACAATGGA CAGAAGAGGT TCCTTCCTGC CAAGTGGTAA AATGTTCAAG CCTGGCAGTT CCGGGAAAGA TCAACATGAG CTGCAGTGGG GAGCCCGTGT TTGGCACTGT GTGCAAGTTC GCCTGTCCTG AAGGATGGAC GCTCAATGGC TCTGCAGCTC GGACATGTGG AGCCACAGGA CACTGGTCTG GCCTGCTACC TACCTGTGAA GCTCCCACTG AGTCCAACAT TCCCTTGGTA GCTGGACTTT CTGCTGCTGG ACTCTCCCTC CTGACATTAG CACCATTTCT CCTCTGGCTT CGGAAATGCT TACGGAAAGC AAAGAAATTT GTTCCTGCCA GCAGCTGCCA AAGCCTTGAA TCAGACGGAA GCTACCAAAA GCCTTCTTAC ATCCTTTAAG TTCAAAAGAA TCAGAAACAG GTGCATCTGG GGAACTAGAG GGATACACTG AAGTTAACAG AGACAGATAA CTCTCCTCGG GTCTCTGGCC CTTCTTGCCT ACTATGCCAG ATGCCTTTAT GGCTGAAACC GCAACACCCA TCACCACTTC AATAGATCAA AGTCCAGCAG GCAAGGACGG CCTTCAACTG AAAAGACTCA GTGTTCCCTT TCCTACTCTC AGGATCAAGA AAGTGTTGGC TAATGAAGGG AAAGGATATT TTCTTCCAAG CAAAGGTGAA GAGACCAAGA CTCTGAAATC TCAGAATTCC TTTTCTAACT CTCCCTTGCT CGCTGTAAAA TCTTGGCACA GAAACACAAT ATTTTGTGGC TTTCTTTCTT TTGCCCTTCA CAGTGTTTCG ACAGCTGATT ACACAGTTGC TGTCATAAGA ATGAATAATA ATTATCCAGA GTTT AGAGGA AAAAAATGAC TAAAAATATT ATAACTTAAA AAAATGACAG ATGTTGAATG CCCACAGGCA AATGCATGGA GGGTTGTTAA TGGTGCAAAT CCTACTGAAT GCTCTGTGCG AGGGTTACTA TGCACAATTT AATCACTTTC ATCCCTATGG GATTCAGTGC TTCTTAAAGA GTTCTTAAGG ATTGTGATAT TTTTACTTGC ATTGAATATA TTATAATCTT CCATACTTCT TCATTCAATA CAAGTGTGGT AGGGACTTAA AAAACTTGTA AATGCTGTCA ACTATGATAT GGTAAAAGTT ACTTATTCTA GATTACCCCC TCATTGTTTA TTAACAAATT ATGTTACATC TGTTTTAAAT TTATTTCAAA AAGGGAAACT ATTGTCCCCT AGCAAGGCAT GATGTTAACC AGAATAAAGT TCTGAGTGTT TTTACTACAG TTGTTTTTTG AAAACATGGT AGAATTGGAG AGTAAAAACT GAATGGAAGG TTTGTATATT GTCAGATATT TTTTCAGAAA TATGTGGTTT CCACGATGAA AAACTTCCAT GAGGCCAAAC GTTTTGAACT AATAAAAGCA TAAATGCAAA CACACAAAGG TATAATTTTA TGAATGTCTT TGTTGGAAAA GAATACAGAA AGATGGATGT GCTTTGCATT CCTACAAAGA TGTTTGTCAG ATGTGATATG TAAACATAAT TCTTGTATAT TATGGAAGAT TTTAAATTCA CAATAGAAAC TCACCATGTA AAAGAGTCAT CTGGTAGATT TTTAACGAAT GAAGATGTCT AATAGTTATT CCCTATTTGT TTTCTTCTGT ATGTTAGGGT GCTCTGGAAG AGAGGAATGC CTGTGTGAGC AAGCATTTAT GTTTATTTAT AAGCAGATTT AACAATTCCA AAGGAATCTC CAGTTTTCAG TTGATCACTG GCAATGAAAA ATTCTCAGTC AGTAATTGCC AAAGCTGCTC TAGCCTTGAG GAGTGTGAGA ATCAAAACTC TCCTACACTT CCATTAACTT AGCATGTGTT GAAAAAAAAA GTTTCAGAGA AGTTCTGGCT GAACACTGGC AACGACAAAG CCAACAGTCA AAACAGAGAT GTGATAAGGA TCAGAACAGC AGAGGTTCTT TTAAAGGGGC AGAAAAACTC TGGGAAATAA GAGAGAACAA CTACTGTGAT CAGGCTATGT ATGGAATACA GTGTTATTTT CTTTGAAATT GTTTAAGTGT TGTAAATATT TATGTAAACT GCATTAGAAA TTAGCTGTGT GAAATACCAG TGTGGTTTGT GTTTGAGTTT TATTGAGAAT TTTAAATTAT AACTTAAAAT ATTTTATAAT TTTTAAAGTA TATATTTATT TAAGCTTATG TCAGACCTAT TTGACATAAC ACTATAAAGG TTGACAATAA ATGTGCTTAT

GTTT-3' (FRAG. NO: ) (SEQ. ED NO: 2479)

5' CCT TGC CTG CTG G-3' (FRAG. NO: 1739) (SEQ. ED NO: 1750)

5'-GTT GTC CC-3' (FRAG. NO: 1740) (SEQ. ID NO:1751)

5'-GTT CTT GGC TTC TTC TGT C-3' (FRAG. NO:1080) (SEQ. ED NO:1090)

5 -GGC TGG TGG-3' (FRAG. NO:1083) (SEQ. ID NO:1093)

5'-CGT TGG CTT CTC GTT GTC CC-3' (FRAG. NO:1081) (SEQ. ID NO:1091)

5'-TGT GGG CTT CTC GTT GTC CC-3' (FRAG. NO:1082) (SEQ. ED NO:1092)

5'-CCC TTC GGG GGC TGG TGG-3' (FRAG. NO:1083) (SEQ. ID NO:1093)

5'-GGC CGT CCT TGC CTG CTG G-3' (FRAG. NO:1084) (SEQ. ID NO:1094)

Human P Selectin Fragments

5'-TTT TCT CTT TCG CTT TCT TTT CGT CTC CTG TTC CTC CTT TT TTG CTG TTT TTT CTC CTT CTT CTC TCC TTT

CTT TTC-3' (FRAG. NO: 1741) (SEQ. ID NO: 1752)

5'-TCC TTT CTT TTC-3' (FRAG. NO: 1742) (SEQ. ID NO: 1753)

5'-CTC CTT TT-3' (FRAG. NO:1743) (SEQ. ID NO:1754)

-, _{τττ τcτ cπ TCG cτr τcτ τrr CGT CTC CTG ζ}, _{CTC cχr} -_jv_j ^, ₃, _(FRAG NO:1085) (SEQ. ID NO:1095)

5'-TTG CTG TTT TTT CTC CTT CTT CTC TCC TTT CTT TTC-3' (FRAG. NO:1086) (SEQ. ID NO:1096)

Human Endothelial Monocvte Activating Factor Nucleic Acid and Antisense Oligonucleotide Fragments

5'-TTT TCT CTT TCG CTT TCT TTT CGT CTC CTG TTC CTC CTT TT TTG CTG TTT TTT CTC CTT CTT CTC TCC TTT

CTT TTC-3' (FRAG. NO: 1744) (SEQ. ID NO: 1755)

5' -CC TTT CTT TTC (FRAG. NO: 1745) (SEQ. ED NO: 1756)

5'-CTG TTC CTC CTT TT-3' (FRAG. NO:1746) (SEQ. ID NO:1757)

S'-TTT TCT CTT TCG CTT TCT TTT CGT CTC CTG TTC CTC CTT TT-3' (FRAG. NO:1087) (SEQ. ID NO:1097)

5'-TTG CTG TTT TTT CTC CTT CTT CTC TCC TTT CTT TTC-3' (FRAG. NO:1088) (SEQ. ID NO:1098)

Human IL3* Nucleic Acid and Antisense Oligonucleotide Fragments

5' -CTC TGT CTT GTT CTG GTC CTT CGT GGG GCT CTG TGT CGC GTG G GTG CGG CCG TGG CC GGC GGB CCB GGB GTT

GGB GCB GGB GCB GGB CGG GCB GGC GGC TCB TGT TTG GBT CGG CBG GBG GCB CTC (FRAG. NO: 1747) (SEQ. ID NO:

1758)

5'-G GBG GCB CTC-3' (FRAG. NO: 1748) (SEQ. ID NO: 1759) (εεiiON αi Oas) (εzii N OYΆΛ) DDDOQHDOXODXDDD-,S

(reiiON cπ Oas) (ZZΠΌN ovaa) ooxoooooo xooxoooxoo-.s

⁽ICIIΌN αi Oas) (IZΠΌN D u-ϋ ooxooxoooxxoooxo33ox-,s

(oεπ N cπ Oas) (OZΠΌN OVUJ) OXOXODXOOXOOOX-.Ϊ

(6ZΪI N αi Oas) (6IIION DVtti) X0X00X1OXXXXX000X0D3X3OXO3X00X0 X00-.S

⁽SZΠΌN αi Oas) (SΠIΌN ovH-i) ooooxooooxooxxooxoooxxo-.s

(Lzivon αi Oas) ⁽-.IΠΌN DVH-I) ODOXXODDXODOOOOXOODOOO-,S

⁽9ZΠΌN αi - as) (9ΠIΌN ov»a) ooxoooooxooxooxxo-.s

(SZΠΌN Π όas) (SΠIΌN ova-ϋ oooxoooxooxooo-.f

⁽KIIΌN αi Oas) (HΠΌN ovHa) oxxxxoo ooooooxox-.s

(εzπ N αi -Oas) (επiON ovaa) oxxxoooxoooooooxooxxxoo-.s

(ZZΠΌN αi -0as) (ZIΠΌN DV&A) oxxooooxoooxoox-,5

(ΠΠΌN αi -Oas) (ΠΠΌN ovπ-i) oxoxxoxxoooxooooooooo-,s

(OZΠΌN CΠ Oas) (OIΠΌN ovM ooo xooooxoxoo-.s

(6III N H Oas) (60II N OVH-I) X3X3X10DD33DD0-.S

⁽8IIΪON CH 'QaS) (801ION DVH-l) 3313DX3D0DDDDDQX0X-.Ϊ

(69-.IO CH "OaS) (8S..I N OVH-l) 0 OOO XOO XOO xoo .s

(89-.T ON n Oas) ⁽LSLi oκ "OVH-l) .ε-ooooxox .s

(L9LI ON αi 03S) (9S..I ON OVH-l⁾ .ε- O XOO 900000900 X90000 X9000900990O 090009090900909 XOO 000009090900009 OOX 009900 XXO XOO V33300 V03 XVO 000 XVO OOV OOV VOD OVO OOV OVO VOO VOV XOO 000 OOV OVO VOO OOV OOX OOV VOO XXO 000 XOO 000 XOO 0X00X0 XOO XXX 000 OOX 0X333X X3D OOX 330 330003 X130130X3 OOX 3003X0000 XXX X03 ODD XOX ODD ODD XOO OOX ODD 0X0 DDO 000 XXX ODD 0X0 0X0000 OOX XXO OOX XOO XOO XOO ODD XOO 0X0000 XOD 100 DXO OXD 0X0 DOO 0000X0 DDO ODD 0X00331X3 X303000X3300 XXO XOO XOO 0X0 XOO XXO 0X0 OOX XOX 010 XOO XXO OOX OXX XXO 0X00X0 XOO OOX 313 DDO X33013 XXO XOO XXO OOX 000000 OOX ODO 000 ODD 0101DD XOO 0X00101DD OXX XOO ODD 001 XOX XOO 133 ODD X33 XXO OXX 000303 OOX 101 OXX OOX ODO 003 DDO 100010001101 ODO 0303310X3330 X3X-.S

(UΠΌN αi Oas) (IOΠΌN ova-i) ,ε-go3XDXDDgχgg g333^gDgDxθDgθDθxxog3oggDDθθogDg3^ggDggDD93ogχoDχgogoDDθθD-.s

(9IΠ^:ON αi -Oas) (9OΠΌN V&Λ) x-oii oox xoo oxx DDX OXO-,Ϊ

(99LVOK αi "Oas) (SSIIΌN ovaa) ,ε-oxx oox x-.s

(S9ii N αi -Oas) (PSLI ON OV&Λ) .ε-gog ooo ooo-.s

(røii ON αi Oas) (εs_.ι ON ΌVHJ) ,ε-g oox Dxo ogχ ggχ χgo

339090 XDO 900 OXX 093099 ODD 009093 ggo g θ DgO DgX OOX 909 ODD 000 OXX OOX X3D DXX OOX 3X3-.S sjuaiuBRj j appoapnuoBiio asuasμuy puB ppy a pnjij -qι UBUIΠJJ

⁽SIΠΌN αi -Oas) (SOΠΌN ovna) O ODX oog ogo-,s goo goo ogg ooo oxo ogo oog goo oox goo goo ^goo ggg ooo ^gox ooo goo goo gox goo ooo goo oog ogo goo goo-.s

(HΠΌN αi Oas) (WHIΌN -ovaa) ODDXOOXXOXXOIIDXOXXD-,S

(εni-ON αi Oas) (εoπON ov^i-D DDDOXQDDXDDDDXDDXX-.S

(ΠΠΌN αi Oas) (ZOΠΌN ov&d) OOOOOOOOOXOODODD-.S

(ΠΠΌN αi Oas) ⁽IOΠΌN OV&Λ) OOOXOOOOOOOIXXOODOODO-.S

(OIIIΌN CΠ Oas) (OOΠΌN OVHI OOXXXXDOXOXXOO-,S

⁽6OΠΌN αi -Oas) ⁽660IΌN ΌVSΛ) DDDXDDXDDXDDIDDDDDDXXXDXDXDD-,S

(80II N αi -03S) (8601ON DVΆΛ) OOXOOXDDDODOXODOD-,S

(iOH N αi -03S) (L60VOK oval) XIOXDDDDDDDXXXDXD-.S

(90IION αi 'Oas) (960ION DVH-l) 0 000 000 OO xoo ox ooo-.s

(SOΠΌN αi Oas) (SOOIΌN ov i) XOODOOOOOOODODDDOOOOXDO-,S (WΠΌN αi Oas) (WOIΌN OVH_I) ODXXXO3XI33XX3X .S

(εOIION αi Oas) (εβOI N DVHi) 33XX00X03XX330 .S (Z0IΪON αi Oas) (Z60ION OVH-l) D1031Q1DDQQX3X-,£

(9a^:θN αi -Oas) (ZSLVOK ovaa) ,ε-3033330 -,s (Z9 I ^:ON αi -Oas) (isii ON OVΆΛ) .1-000X0090

(i9Li ON αi Oas) (osii ON Dvaa) ,ε-33 oxo ogo gog oog ooo ggo ooo xoo goo ogg ODD oxg oog oog oog ggo oog oxo oog oog oog oxg ooo oog ooo ogo gog oog oo o oox oov ovo voo voo ovv ooo oxo ovo oov voo oox voo voo voo

VW 000 VOX 000 VOO VDD VOX VOO ODD VOD DDV OVO VOO V30300 X03 XX3 XX3 XXO 1011000001000X3 ODD X33 XX3300333 OOX 330300333 X330333DX XX300330000 XXX XDO XOX XOO 000 XOD XOO XOO XOO 000 DXX XDX DXO 000 XOO XDO 0000X0000 XXO XOD ODO OOX XXO XOO DOO OOD XOO XOO OOX ODD XO 000000 000 ODD DDO DOO XOO OOX XXO OXX OOX XOX OOX XOD XOO XXO ODO XOO XDX OOD 0X0 XOO DXO OXX 0X1 OXX DXO XXD 0000X0 OOX ODD DXO OXX 00 ODO OOD 010 ODO 000001000000 OXX XOO 033 DOO 0X1 XXD 3X01X3030 3X00X33X33X 333030 XXX OXD 10333 X30 XOD OOD 0X3030 XXO XOO ODO OOX XXO XOO DOO OOD XOO XOO ODX ODD X33 ODD 333330 OOD 03003X 033 OXX XD3 XX33XX 3X3311001031 X33 ODX 33X 0X0 ODO X3X-.S

(IOII-ΌN αi Oas) (iβoiON

ΌVHJ) 3X3 g30 ogo ogo DOO χgo on iDi gox ODD ODD goo ooo goo goo goo goo goo xxo goo goo goo ooo

(OOΠΌN αi -Oas) (06OIΌN OVUΛ) ,ε-oo oox 033 ODD DXD O OXO 303 xox-.s :zswετιwnH

(660ION OT -OaS) (6801ON DVtt>I) ,ε-DX3 X3D 000 XD3 XX3 OXD 0X0 XXO 1X0 1010X0 ,5 SWεi ΩH

(09iiON n -Oas) (6«,IΌN ovaa) .ε-oxo xoo ODD XD ,S Ll 601-MH ziLLimsn/±Dd SZSOO/OO OΛΛ EPI-109 175

5'-CTCTGGGTCGGGCTGGC (FRAG. NO:1124) (SEQ. ID NO:1134) 5'-GGGGCGTCTCTGTGC (FRAG. NO:1125) (SEQ. ID NO:1135) 5'-CTGGCCTGGGTGCC (FRAG. NO:1126) (SEQ. ED NO:1136)

5'-GCCTCTCCTGGGGGGGTGGCTCCCTGTCC (FRAG. NO:1127) (SEQ. ED NO:1137) 5'-CCTπTCCCCCGGCTCC (FRAG. NO:1128) (SEQ. ED NO:1138) 5'-GTGGGGGCTTTGGC (FRAG. NO:1129) (SEQ. ID NO:1139) 5'-GGG GGT CTG TGG CCT GCT CCT GGG G (FRAG. NO:1130) (SEQ. ED NO:1140) 5 -AGGGGTCTGGGGCCCTC (FRAG. NO:1131) (SEQ. ID NO:1141) 5'-TTTTGGGGGTCTGGCTTG (FRAG. NO:1132) (SEQ. ID NO:1142) 5'-GCCTGGCTGCCTTCC (FRAG. NO:1133) (SEQ. ED NO:1143) 5 -GGGGCCTGCCGTGGGGC (FRAG. NO:1134) (SEQ. ED NO:1144) 5'-TGTCCTCTGTTGCTCCCCTT (FRAG. NO:1135) (SEQ. ID NO:1145) 5'-TGCCTGCTGTCTGG (FRAG. NO:1136) (SEQ. ID NO:1146) S'-GGTTCCCGCCTTCCCT (FRAG. NO:1137) (SEQ. ID NO.-1147)

5'-GTT CCC AGA GCT TGC CAC CTG CAG CAG GAC CAG GCA GCT CAC AGG GAA CAG GAG CCC AGA GCA AAG CCA CCC CAT TGG GAG ATG CCA AGG CAC CAG GCT G (FRAG. NO:1138) (SEQ. ID NO:1148)

S'-GTT CCC BGB GCT TGC CBC CTG CBG CBG GBC CBG GCB GCT CBC BGG GBB CBG GBG CCC BGB GCB BBG CCB CCC CBT TGG GBG BTG CCB BGG CBC CBG GCT G-3' (FRAG. NO:1139) (SEQ. ID NO:1149) Human IL5* Nucleic Acid and Antisense Oligonucleotide Fragments

5'-TCCCTGTTTC CCCCCTTTCG TTCTGCGTTT GCCTTTGGCG TTTTTTGTTT GTTTTCTCTC TCCGTCTTTC TTCTCCCCT GTGGGBBTTT CTGTGGGGBT GGCBTBCBCG TBGGCBGCTC CBBGBGCTBG CBBBCTCBBB TGCBGBBGCB TCCTCBTGGC TCTGBBBCGG TGGGAATTTC TGTGGGGBTG GCATACACGT AGGCAGCTCC AAGAGCTAGC AAACTCAAAT GCAGAAGCATC CTCATGGCTC TGAAACG-3' (FRAG. NO: 1759) (SEQ. ID NO: 1770) 5'-GCC CCG GG-3' (FRAG. NO: 1760) (SEQ. ID NO: 1771) 5'-G GGT TTC T-3' (FRAG. NO: 1761) (SEQ. ID NO: 1772) 5'-GTG GGG BTG GC-3' (FRAG. NO: 1762) (SEQ. ID NO:1773_) 5'-CCB BGB GCT BGC-3' (FRAG. NO: 1763) (SEQ. ID NO: 1774) 5'-TCC CTG TTT CCC CCC TTT-3' (FRAG. NO:1140) (SEQ. ID NO:1150) 5'-CGT TCT GCG TTT GCC TTT GGC-3' (FRAG. NO:1141)(SEQ. ID NO:1151) 5'-GTT TTT TGT TTG TTT TCT-3' (FRAG. NO:1142)(SEQ. ED NO:1152) 5'-CTC TCC GTC TTT CTT CTC C-3' (FRAG. NO:1143) (SEQ. ID NO:1153) 5'-CCT CCT GCC TGT GTC CCT GCT CCC C-3' (FRAG. NO:1144) (SEQ. ID NO:1154) 5'-GAG GGT TTC TGG CTT CCT CTC T-3' (FRAG. NO:1145) (SEQ. ID NO:1155) 5'-TGT CTC TCT GTC CTT TTG TT-3' (FRAG. NO:1146) (SEQ. ED NO:1156) 5'-TGT TGT GCG GCC TGG TGC TGC CCT GCC CCG GG-3' (FRAG. NO:1147) (SEQ. ID NO:1157)

5' -GTG GGA ATT TCT GTG GGG BTG GCA TAC ACG TAG GCA GCT CCA AGA GCT AGC AAA CTC AAA TGC AGA AGC ATC CTC ATG GCT CTG AAA CG-3' (FRAG. NO: 1764) (SEQ. ID NO: 1775)

5'-GTG GGB BTT TCT GTG GGG BTG GCB TBC BCG TBG GCB GCT CCB BGB GCT BGC BBB CTC BBB TGC BGB BGC BTC CTC BTG GCT CTG BBB CG-3' (FRAG. NO:1148) (SEQ. ID NO:1158) Human IL-5 Receptor Nucleic Acid and Antisense Oligonucleotide Fragments

5'-CTCAGTGGCC CCCAAAAGGA TGAGTAATAC ATGCGCCACG ATGATCATAT CCTTTTTACT ATGAGGCCGT GTCTGTCGTG TCTTTCCTTT GCTCTTGGTG TGTCTTTGCT GTGCCCTGCC TCTCTGCCCG TGTCTGTCGT GTCTTTCCTT TGCTCTTGGT GTGTCTTTGC TGTGCCCTGC CTCTCTGCC CGTGTCTGTC GTGTCTTTCC TTTGCTCTTG GTGTGTCTTT GCTGTGCCCT GCCTCTCTGC-3' (FRAG. NO: 1765) (SEQ. ID NO: 1776) 5 -CCG TGT C-3' (FRAG. NO: 1766) (SEQ. ID NO: 1777) 5 -GCCCTGCC-3' (FRAG. NO: 1767) (SEQ. ED NO: 1778) 5 -CCG TGT CTG TCG TGT CT-3' (FRAG. NO:1149) (SEQ. ID NO:1159) 5'-TTCCTTTGCTCTTG-3' (FRAG. NO:1150) (SEQ. ID NO:1160) 5'-GTGTGTCTTTGCTGT-3' (FRAG. NO:1151) (SEQ. ID NO:1161) 5'-GCCCTGCCTCTCTGC-3' (FRAG. NO:1152) (SEQ. ID NO:1162)

5'-CT CBGTGGCCCC CBBBBGGBTG BGTBBTBCBT GCGCCBCGBT GBTCBTBTCC TTTTTBCTBT GBGG (FRAG. NO: 1768) (SEQ. ID NO: 1779)

Human IL-6 Receptor Fragments

5'-GGGGGTGGCT TCCTGCCGCG TCTCTGGGCC GTCCCGTCCC TCGGCCCCGC GCCGCGCTCG GCTCCTCTCC CTCTGGCCCG GCTCGGGGCG GGGCGGGGCG GTGGGCGGGC GGCGCTGCCC TGCGCGCGGC GCTGGCCCCT GCTGGCCGTC GGCTGCGCGC TGCTGGCTGC CCTGCTGGCC GCGCCGGGGC CTGTCCGCCT CTGCGGGCGC TGTCTCCTGG CTTGTCTTCC GGCTCTTCTG CTGGGGTGGG GCTGGGCGGC CGGCCCGGTG CTGGGGCTCC TCGGGGGGGG GGGCTCTTCC GGGCTGTCTC CCTCCGGGGC GGGGGTTTCT GGCCGTGGGG GTCTTGCCTG GCCTCCGGGC TCCTGCTTGT CTTGCCTTCC TTCTCTGGTC GGTTGTGGCT CGGGGCTCCG TGGGTCCCTG GCGCCCGTTT GTGTTTTGTC TTTTCCCCTG GCGTCCCTGT GCCCCTCTCC TCTCCTTCCT CTGCTTCTCG CTCTCCTTTG TGGGGCCCTC CCTGCTGCTC TTGGTTTTGG GCTTTTTTTC TCTTCCTCCT TTTTCGTGCG TGGGCCTCCG CACGCCTCTT GCCACCTCCT GCGCAGGGCA GCGCCTTGG GGCCAGCGCC GCTCCCGGCG CGGCCAGCAG GGCAGCCAGC AGCGCGCAGC CGACGGCCAG CATGCTTCCT CCTCGGCTAC CACTCCATGG TCCCGCAGAG GCGGACAGGC GCBCGCCTC TTGCCBCCTC CTGCGCBGGG CBGCGCCTTG GGGCCBGCGC CGCTCCCGGC GCGGCCBGCB GGGCBGCCBG CBGCGCGCBG CCGBCGGCCB GCBTGCTTCC TCCTCGGCTB CCBCTCCBTG GTCCCGCBGB GGCGGBCBGG C-3' (FRAG. NO: 1769) (SEQ. ID NO: 1780) 5 -CCCGGCGC-3' (FRAG. NO:1184) (SEQ. ED NO:1194) 5 -GGCCBGCBGG-3' (FRAG. NO:1186) (SEQ. ID NO:1196) 5'-GCBGCCBGCBGCG-3' (FRAG. NO: 1770) (SEQ. ED NO: 1781) EPI-109 176

5'-C GCBGCCGBCGGCC -3' (FRAG. NO: 1771) (SEQ. ID NO: 1782) 5 -GGGGGTGGCTTCCTGCC3 - (FRAG. NO:1153) (SEQ. ID NO:1163) 5'-GCGTCTCTGGGCCGTCCC-3' (FRAG. NO:1154) (SEQ. ID NO:1164)

5'-GTCCCTCGGCCCCGCGCCGCGCTCGGCTCCTCTCCC-3' (FRAG. NO:1155) (SEQ. ID NO:1165) 5'-TCTGGCCCGGCTC-3' (FRAG. NO:1156) (SEQ. ID NO:1166) 5'-GGGGCGGGGCGGGGCGGTGGGCGGGC-3' (FRAG. NO:1157) (SEQ. ID NO:1167) 5'-GGCGCTGCCCTGCGC-3' (FRAG. NO:1158) (SEQ. ID NO:1168) 5 -GCGGCGCTGGCCCC-3' (FRAG. NO:1159) (SEQ. ED NO:1169)

5'-TGCTGGCCGTCGGCTGCGCGCTGCTGGCTGCCCT-3' (FRAG. NO:1160) (SEQ. ED NO:1170) 5 -GCTGGCCGCGCCGGG-3' (FRAG. NO:1161) (SEQ. ED NO:1171) 5'-GCCTGTCCGCCTCTGCGGG-3' (FRAG. NO:1162) (SEQ. ED NO:1172) 5'-CGCTGTCTCCTGGC-3' (FRAG. NO:1163) (SEQ. ED NO:1173) 5'-TTGTCTTCCGGCTCT-3' (FRAG. NO:1164) (SEQ. ED NO:lI74) 5'-TCTGCTGGGGTGGG-3' (FRAG. NO:1165) (SEQ. ID NO:1175) 5 -GCTGGGCGGCCGGCCCGGT-3' (FRAG. NO:1166) (SEQ. ID NO:1176) 5 -GCTGGGGCTCCTCGGGGGG-3' (FRAG. NO:1167) (SEQ. ED NO:1177) 5'-GGGGGCTCTTCCGG-3' (FRAG. NO:1168) (SEQ. ED NO:1178) 5'-GCTGTCTCCCTCCGGG-3' (FRAG. NO:1169) (SEQ. ID NO:1179) 5 -GCGGGGGTTTCTGGCC-3' (FRAG. NO:1170) (SEQ. ID NO:1180) 5 -GTGGGGGTCTTGCC-3' (FRAG. NO:1171) (SEQ. ID NO:1181) 5'-TGGCCTCCGGGCTCC-3' (FRAG. NO:1172) (SEQ. ID NO:1182) 5'-TGCTTGTCTTGCCTTCCTTC-3' (FRAG. NO:1173) (SEQ. ID NO:1183) 5'-TCTGGTCGGTTGTGGCTCG-3' (FRAG. NO:1174) (SEQ. ED NO:1184) 5'-GGGCTCCGTGGGTCCCTGGC-3' (FRAG. NO:1175) (SEQ. ID NO:1185) 5'-GCCCGTTTGTGTTTTGTC-3' (FRAG. NO:1176) (SEQ. ID NO:1186) 5'-TTTTCCCCTGGCGT-3' (FRAG. NO:1177) (SEQ. ID NO:1187)

5'-CCCTGTGCCCCTCTCCTCTCCTTCCTCTGCTTCTC-3' (FRAG. NO:1178) (SEQ. ID NO:1188) 5'-GCTCTCCTTTGTGGG-3' (FRAG. NO:1179) (SEQ. ID NO:1189) 5'-GCCCTCCCTGCTGCT-3' (FRAG. NO:1180) (SEQ. ID NO:1190) 5 -CTTGGTTTTGGGCT-3' (FRAG. NO:1181) (SEQ. ID NO:1191) 5 ' -TTTTTTCTCTTCCTCCrr riTC-3 ' (FRAG. N0:1182) (SEQ. ID NO:1192) 5 -GTGCGTGGGCCTCC-3' (FRAG. NO:1183) (SEQ. ID NO:1193) 5'-

GCACGCCTCTTGCCACCTCCTGCGCAGGGCAGCGCCTTGGGGCCAGCGCCGCTCCCGGCGCGGCCAGCAGGGCAGCCAGCAGCG CGCAGCCGACGGCCAGCATGCTTCCTCCTCGGCTACCACTCCATGGTCCCGCAGAGGCGGACAGGC-3' (FRAG. NO:1185) (SEQ. ID NO:1195) 5'-

GCBCGCCTCTTGCCBCCTCCTGCGCBGGGCBGCGCCTTGGGGCCBGCGCCGCTCCCGGCGCGGCCBGCBGGGCBGCCBGCBGCGC GCBGCCGBCGGCCBGCBTGCTTCCTCCTCGGCTBCCBCTCCBTGGTCCCGCBGBGGCGGBCBGGC-3' (FRAG. NO:1187) (SEQ. ID NO:U97)

Human IL-6 Nucleic Acid and Antisense Oligonucleotide Fragments

5 -GGGGGTGGCT TCCTGCCGCG TCTCTGGGCC GTCCCGTCCC TCGGCCCCGC GCCGCGCTCG GCTCCTCTCC CTCTCGCCCG GCTCGGGGCG GGGCGGGGCG GTGGGCGGGC GGCGCTGCCC TGCGCGCGGC GCTGGCCCCT GCTGGCCGTC GGCTGCGCGC TGCTGGCTGC CCTGCTGGCC GCGCCGGGGC CTGTCCGCCT CTGCGGGCGC TGTCTCCTGG CTTGTCTTCC GGCTCTTCTG CTGGGGTGGG GCTGGGCGGC CGGCCCGGTG CTGGGGCTCC TCGGGGGGGG GGGCTCTTCC GGGCTGTCTC CCTCCGGGGC GGGGGTTTCT GGCCGTGGGG GTCTTGCCTG GCCTCCGGGC TCCTGCTTGT CTTGCCTTCC TTCTCTGGTC GGTTGTGGCT CGGGGCTCCG TGGGTCCCTG GCGCCCGTTT GTGTTTTGTC TTTTCCCCTG GCGTCCCTGT GCCCCTCTCC TCTCCTTCCT CTGCTTCTCG CTCTCCTTTG TGGGGCCCTC CCTGCTGCTC TTGGTTTTGG GCTTTTTTTC TCTTCCTCCT TTTTCGTGCG TGGGCCTCC GCACGCCTCT TGCCACCTCC TGCGCAGGGC AGCGCCTTGG GGCCAGCGCC GCTCCCGGCG CGGCCAGCAG GGCAGCCAGC AGCGCGCAGC CGACGGCCAG CATGCTTCCT CCTCGGCTAC CACTCCATGG TCCCGCAGAG GCGGACAGGC GCBCGCCTC TTGCCBCCTC CTGCGCBGGG CBGCGCCTTG GGGCCBGCGC CGCTCCCGGC GCGGCCBGCB GGGCBGCCBG CBGCGCGCBG CCGBCGGCCB GCBTGCTTCC TCCTCGGCTB CCBCTCCBTG GTCCCGCBGB GGCGGBCBGG C-3¹ (FRAG. NO:1772) (SEQ. ID NO:1783)

5 -GGGGCBGG-3' (FRAG. NO:1773) (SEQ. ID NO:1784) 5 -GBBGGCBG CBGGC-3' (FRAG. NO:1774) (SEQ. ID NO:1785) 5'-CCBGGBGCBG CCCC-3' (FRAG. NO:1775) (SEQ. ID NO:1786) 5'-BGGG BGBBGGCBBC-3' (FRAG. NO:1776) (SEQ. ID NO:1787) 5'-GCT TCT CTT TCG TTC CCG GTG GGC TCG-3' (FRAG. NO:1188) (SEQ. ID NO:1198) 5'-GTG GCT GTC TGT GTG GGG CGG CT-3' (FRAG. NO:1189) (SEQ. ID NO:1199) 5'-GTG CCT CTT TGC TGC TTT C-3' (FRAG. NO:1190) (SEQ. ID NO:1200) 5'-GAT TCT TTG CCT TTT TCT GC-3' (FRAG. NO:1191) (SEQ. ID NO:1201)

5'-CTCCTGGGGG TBCTGGGGCB GGGBBGGCBG CBGGCBBCBC CBGGBGCBGC CCCBGGGBGB BGGCBBCTGG BCCGBBGGCG CTTGTGGBGB BGGBGTTCBT BGCTGGGCTC CTGGBGGGGB GBTBGBGC-3' (FRAG. NO:1777) (SEQ. ID NO:1788) Human Monocyte-derived Neutrophil Chemotactic Factor Nucleic Acid and Antisense Oligonucleotide Fragments

5'-GGGGTGGBBB GGTTTGGBGT BTGTCTTTBT GCBCTGBCBT CTBBGTTCTT TBGCBCTCCT TGGCBBBBCT GCBCCTTCBC BCBGBGCTGC BGBBBTCBGG BBGGCTGCCB BGBGBGCCBC GGCCBGCTTG GBBGTCBTGT TTBCBCBCBG TGBGBTGGTT CCTTCCGGGC TTGTGTGCTC TGCTGTCTCT TGGTTCCTTC CGGTGGTTTC TTCCTGGCTC TTGTCCTTTC TCTTGG CCCT TGGC-3' (FRAG. NO:1778) (SEQ. ID NO: 1789) bPl-109 177

5 -GGBGT BTG-3' (FRAG. NO:1779) (SEQ. ED NO: 1790)

5'-GCBCTGBCBT CT-3' (FRAG. NO:1780) (SEQ. ED NO:1791)

5 -CCG GTG G-3' (FRAG. NO:1781) (SEQ. ID NO: 1792)

5'-GG CCC TTG GC-3' (FRAG. NO:1782) (SEQ. ID NO: 1793)

5'-GCT TGT GTG CTC TGC TGT CTC T-3' (FRAG. NO:1192) (SEQ. ID NO:1202)

5'-TGG TTC CTT CCG GTG GTT TCT TCC TGG CTC TTG TCC T-3' (FRAG. NO:1193) (SEQ. ID NO:1203)

5'-TTC TCT TGG CCC TTG GC-3' (FRAG. NO:1194) (SEQ. ID NO:1204)

5 -GGGGTGGBBB GGTTTGGBGT BTGTCTTTBT GCBCTGBCBT CTBBGTTCTT TBGCBCTCCT TGGCBBBBCT GCBCCTTCBC

BCBGBGC-3' (FRAG. NO:1783) (SEQ. ID NO: 1794)

Human Neutrophil Elastase (Medullasin) Nucleic Acid and Antisense Oligonucleotide Fragments

5'-GGGCTCCCGC CGCGBGBGGT TBTGGGCTCC CBGGBCCBCC CGCBCCGCGC GGBCGTTTBC BTTCGCCBCG CBGTGCGCGG

CCGBCBTGBC GBBGTTGGGC GCBBTCBGGG TGGCGCCGCB GBBGTGGCCT CCGCGCBGCT GCBGGGBCBC CBTGBBGGGC

CBCGCGTGGG GCCGCGCTCG CCGGCCCCCC BCBBTCTCCG BGGCCBGCGC GGTGCCCCCC BGCBGCBBGG CCGGCBGGBC

BCBGGCGBGG BGBCBCGCGB GTCGGCGGCC GBGGGTCBTG GTGGGGCTGG GGCTCCGGGG TCTCTGCCCC TCCGTGCTGG

TGGGGCTGGG GCTCCGGGG TCTCTGCCCC TCCGTGCCGC GTGGGGCCGC GCTCGCCGGC CCCCCCCTGC CGGGTGGGCT

CCCGCCGCGC GCCGGCCTGC CGGCCCCTCG TGGGTCCTGC TGGCCGGGTC CGGGTCCCGG GGGTGGGGCG CGBGTCGGCG

GCCGBGGGTC-3' (FRAG. NO:1784) (SEQ. ID NO: 1795)

5 -GG TGG GGC-3' (FRAG. NO:1785) (SEQ. ED NO: 1796)

5 '-G GGG CCG -3' (FRAG. NO:1786) (SEQ. ED NO: 1797)

5 - GGC CGG GTC CGG G-3' (FRAG. NO:1787) (SEQ. ID NO: 1798)

5'-TGG TGG GGC TGG GGC TCC GGG GTC TCT GCC CCT CCG TGC-3' (FRAG. NO:1195) (SEQ. ID NO:1205)

5'-CGC GTG GGG CCG CGC TCG CCG GCC CCC C-3' (FRAG. NO:1196) (SEQ. ED NO:1206)

5'-CCT GCC GGG TGG GCT CCC GCC GCG-3' (FRAG. NO:1197) (SEQ. ED NO:1207)

5'-CGC CGG CCT GCC GGC CCC TC-3' (FRAG. NO:1198) (SEQ. ED NO:1208)

5'-GTG GGT CCT GCT GGC CGG GTC CGG GTC CCG GGG GTG GGG-3' (FRAG. NO:1199) (SEQ. ID NO:1209)

5'-CGC GBG TCG GCG GCC GBG GGT C-3' (FRAG. NO:1200) (SEQ. ID NO:1210)

5 -GGGCTCCCGC CGCGBGBGGT TBTGGGCTCC CBGGBCCBCC CGCBCCGCGC GGBCGTTTBC BTTCGCCBCG CBGTGCGCGG

CCGBCBTGBC GBBGTTGGGC GCBBTCBGGG TGGCGCCGCB GBBGTGGCCT CCGCGCBGCT GCBGGGBCBC CBTGBBGGGC

CBCGCGTGGG GCCGCGCTCG CCGGCCCCCC BCBBTCTCCG BGGCCBGCGC GGTGCCCCCC BGCBGCBBGG CCGGCBGGBC

BCBGGCGBGG BGBCBCGCGB GTCGGCGGCC GBGGGTCBTG GTGGGGCTGG GGCTCCGGGG TCTCTGCCCC TCCGTGC-3'

(FRAG. NO:1788) (SEQ. ID NO: 1799)

Human Neutrophil Oxidase Factor Nucleic Acid and Antisense Oligonucleotide Fragments

5 -CGGGBGTGGG GGTCCTGGBC GGCBCTGBBG GCBTCCBGGG CTCCCTTCCB GTCCTTCTTG TCCGCTGCCB GCBCCCCTTC

BTTCCBGBGG CTGBTGGCCT CCBCCBGGGB CBTGBTTBGG TBGBBBCTBG GBGGCCGGCC TCCBCCBGGG BCBTGGTCCT

TCTTGTCCGC TGCCTCTCTG GGGTTTTCGG TCTGGGTGGG CTTTCCTCCT GGGGCTGCTG CTGGGCTCTT CTTTTTGTTT

CTGGCCTGGT GCTCTCTCGT GCCCTTTCCC TTGGGTGTCT TGTTTTTGTG GCCTCCBCCB GGGBCBTG-3' (FRAG. NO:1789)

(SEQ. ID NO: 1800)

5'-CGGGBGTGGG GG-3 ' (FRAG.NO:1790) (SEQ. ED NO: 1801)

5'-GCCBGCBCCCC-3' (FRAG.NO:1791) (SEQ. ID NO: 1802)

5 -C CBC CBG-3' (FRAG.NO:1792) (SEQ. ΪD NO: 1803)

5'-GGC CTC CBC CBG GGB CBT G-3' (FRAG. NO:1201) (SEQ. ID NO:1211)

5'-GTC CTT CTT GTC CGC TGC C -3' (FRAG. NO:1202) (SEQ. ID NO:1212)

5'-TCT CTG GGG TTT TCG GTC TGG GTG G-3 (FRAG. NO:1203) (SEQ. ID NO:1213)

5'-GCT TTC CTC CTG GGG CTG CTG CTG-3' (FRAG. NO:1204) (SEQ. ID NO:1214)

5'-GGC TCT TCT TTT TGT TTC TGG CCT GGT G-3' (FRAG. NO:1205) (SEQ. ID NO:1215)

5'-CTC TCT CGT GCC CTT TCC-3' (FRAG. NO:1206) (SEQ. ID NO:1216)

S'-CTT GGG TGT CTT GTT TTT GT-3' (FRAG. NO:1207) (SEQ. ID NO:1217)

5'-GGC CTC CBC CBG GGB CBT G-3' (FRAG. NO:1208) (SEQ. ID NO:1218)

5'-CGGGBGTGGG GGTCCTGGBC GGCBCTGBBG GCBTCCBGGG CTCCCTTCCB GTCCTTCTTG TCCGCTGCCB GCBCCCCTTC

BTTCCBGBGG CTGBTGGCCT CCBCCBGGGB CBTGBTTBGG TBGBBBCTBG GBGGCC-3' (FRAG. NO:1793) (SEQ. ID NO:

1804)

Human Cathepsin G Nucleic Acid and Antisense Oligonucleotide Fragments

5'-CCCTCCBCBT CTGCTCTGBC CTGCTGGBCT CTGGBTCTGB BGBTBCGCCB TGTBGGGGCG GGBGTGGGGC CTGCTCTCCC

GGCCTCCGBT GBTCTCCCCT GCCTCBGCCC CBGTGGGTBG GBGBBBGGCC BGCBGBBGCB GGBGTGGCTG CBTCTTTCCT

GGTGGGGCCT GCTCTCCCGG CCTCCGTGTG TTGCTGGGTG TTTTCCCGTC TCTGGTCTGC CTTCGGGGGT CGT-3' (FRAG.

NO:1794) (SEQ. ED NO: 1805)

5'-GBBGBTBCGCC-3' (FRAG. NO:1795) (SEQ. ID NO: 1806)

5'-CBGCCCCBG-3' (FRAG. NO:1796) (SEQ. ID NO: 1807)

5'-TCC CGT CTC TGG-3' (FRAG. NO:1797) (SEQ. ED NO: 1808)

5'-GTG GGG CCT GCT CTC CCG GCC TCC G-3' (FRAG. NO:1209) (SEQ. ID NO:1219)

5'-TGT GTT GCT GG GTG TTT TCC CGT CTC TGG-3' (FRAG. NO:1210) (SEQ. ED NO:1220)

5'-TCT GCC TTC GGG GGT CGT-3' (FRAG. NO:1211) (SEQ. ID NO:1221)

5'-CCCTCCBCBT CTGCTCTGBC CTGCTGGBCT CTGGBTCTGB BGBTBCGCCB TGTBGGGGCG GGBGTGGGGC CTGCTCTCCC

GGCCTCCGBT GBTCTCCCCT GCCTCBGCCC CBGTGGGTBG GBGBBBGGCC BGCBGBBGCB GGBGTGGCTG-3' (FRAG.

NO:1798) (SEQ. ID NO: 1809)

Human Defensin 1 Nucleic Acid and Antisense Oligonucleotide Fragments

5'-CCGGGGCTGC BGCBBCCTCB TCBGCTCTTG CCTGGBGTGG CTCBGCCTGG GCCTGCBGGG CCBCCBGGBG BBTGGCBGCB

BGGBTGGCGB GGGTCCTCBT GGCTGGGGTC BCBGBTCCTC TBGCTBGGCB GGGTGBCCBG BGBGGGC GGG TCC TCB TGG EPI-109 178

CTG GGG GCC TGG GCC TGC BGG GCC GCT CTT GCC TGG BGT GGC TC GCC CBG BGT CTT CCC TGG T GCTCAGCCTC CAAAGGAGCC AGCCTCTCCC CAGTTCCTGA AATCCTGAGT GTTGCCTGCC AGTCGCCATG AGAACTTCCT ACCTTCTGCT GTTTACTCTC TGCTTACTTT TGTCTGAGAT GGCCTCAGGT GGTAACTTTC TCACAGGCCT TGGCCACAGA TCTCATCATT ACAATTGCGT CAGCAGTGGA GGGCAATGTC TCTATTCTGC CTGCCCGATC TTTACCAAAA TTCAAGGCAC CTGTTACAGA GGGAAGGCCA AGTGCTGCAA GTGAGCTGGG AGTGACCAGA AGAAATGACG CAGAAGTGAA ATGAACTTTT TATAAGCATT CTTTTAATAA AGGAAAATTG CTTTTGAAGT AT CTGCAGTGGT AAAAAGATTC TATATCTGCT GTTTGATGAA TGCAGCACCC ACTAGCCACA TAGTGCTCGT GAGCACTTGC AATGCGGCTA GGGTGATTTC AATTAACCTA AAAGAGAACA GCCACAGGGA GCATGTGGCT GCCATATTGG ATGGTGCTGC TTTGAGAACA AAATGAGAGA AATGAAGCCT CTATTTACCT TGGTTGGCGG AACACATTGA AGGGACTCTG TATTGATACC AGGCTTCAAA CTTTGGGAAG TGTACTGGCC AACTTAAACA CATCCACAGG AGAATGAAGA GGTTTGGGAA GGGACCAGAA ACCAGGCATT GAGGACAATG AGAAGAGTTT TTCAAAAGTG GAATTACTGC AAAAAGTGGA AAAATAGCCT TTGGATGGAA GTTACTGATG AGACAATTTC CATCGGTGTG AAAGCCATCT TTCCAACAGA GATCTGCAAC ATGAGAATGT ACTGTCTCCT AGGGTAGCGA TGGCCTCTTG TATTAGTCCG CTCAGGCTAC CAGATTTATC GTTTAAACTG CCCATAAACA GACCAGGCAG TTTAAACAAC AGAAATTTAT TTCCTCGCAG TCCTGGAGGC AGGAAGTCTG CGATCAAGGT GGAAGCAGGG TTGGCTTCTT CTCAGGTGTC TGTCCTTGGC TGGTAGATGA CCGCCGCCTC CCTGGGTCCT CACATGGTCT TTCCTCTGTG TGTGTCTGTC CCAATCTCTT CTTATAAGGA TGCAAGTCTT ATGGATCAGA GCACACCCCA ATGACCGTGT TTAACTTGAA TCACCTCTTT AAAGTTTCTC TCTCCAAATA CAATCACCTC CTGAGGCACT GTTAGGGCTT CGACACAGGA ATTCTTTTCC TAGGGGATTC AGTTCAGTCC AAAACGCCTA CCAGTGGAGA CTTGCAACAT GGCGGCCTGC TGGTCCCTCG CCAGGAATAT CACAGGCGAC TGTTCCCTGT TGCATGGAAT AGAAGGCTAT TCCAGAGTAC TGTCTCTATT TATCAGATCT GGGATACTGG GAGAAGGGCA AAATAAAGTC CAAGTAGAAA AAAAAACTAT GAAAGTTTTA GAGAGTAACC ATAATTTCAG CCCGATGTGA AACGATCCTA GATTTCAGCT GAAATAGTGA TGTGGGAAGT GAGGGGGCCG GGATTCAAGG CAGAGGGAAC AGCGTAACTG AAGGCATGGA AGGAGGGAAG TGTAGGCTGT GTTTGAAGAG TGGCAGCTGC TTCCACATTT CTAAAACACA GGATGTGATT TTGGGGTGTG TTGAGACAAG GCAGAAAACT TGTTTGGAAA AATAACTTGA ATTCCCTGCA CATTTAAAAT CTCTCAGCAG AAGAAAACCC CACTCAGAAC CCCACTGTTC ATTCCTTGGC TTGTATTTGG SCACAGCTGG CATAGCCCCA GACTGAGTAA GCTCTTCAGA CACCTCATTT CATGAGTAGC CCCAAAGATC AATCATGGGC CAATTTCTTG GAAGAGAAGA CTCTCCGGTG TTTTGCAGTT ATTTGTTCTG CTTTCGCGAG ATGTTCTCAA ATCGTTGCAG CTACAAGCCA TGAGTCTGAA GTGTTTGTGT TCCCTCCTTA CAGGTGGTAA CTTTCTCACA GGCCTTGGCC ACAGATCTGA TCATTACAAT TGCGTCAGCA GTGGAGGGCA ATGTCTCTAT TCTGCCTGCC CGATCTTTAC CAAAATTCAA GGCACCTGTT ACAGAGGGAA GGCCAAGTGC TGCAAGTGAG CTGAGAGTGA CCAGAAGAAA TGACGCAGAA GTGAAATGAA CTTTTTATAA GCATTCTTTT AATAAAGGAA AATTGCTTTT GAAGTATACC TCCTTTGGGC CAAAATGAAT CTTGTGTCTC AATTGGAAGA GGTAAAGAAG TAGGGGGTTA GGGTGCATGG GTTGGAACGT GAGACAGGTC GAACCACAAA GCCTGCCTGG AAAAGGGGAG TGACGTCCTA GGCTTCAGTG ATGTCACCTC CACTTTGTTT GATCCACAAA CCAACAGGTG ACTGATTTTG GTCAGCTCAG CCTCCAAAGG AGCCAGCCTC TCCCCAGTTC CTGAAATCCT GAGTGTTGCC TGCCAGTCGC CATGAGAACT TCCTACCTTC TGCTGTTTAC TCTCTGCTTA CTTTTGTCTG AGATGGCCTC AGGTGGTAAC TTTCTCACAG GCCTTGGCCA CAGATCTGAT CATTACAATT GCGTCAGCAG TGGAGGGCAA TGTCTCTATT CTGCCTGCCC GATCTTTACC AAAATTCAAG GCACCTGTTA CAGAGGGAAG GCCAAGTGCT GCAAGTGAGC TGGGAGTGAC CAGAAGAAAT GACGCAGAAG TGAAATGAAC TT -3' (FRAG.NO:1799) (SEQ. ID NO: 1810)

5 '-GTCAGCTCAG CCTCCAAAGG AGCCAGCCTC TCCCCAGTTC CTGAAATCCT GAGTGTTGCC TGCCAGTCGC CATGAGAACT TCCTACCTTC TGCTGTTTAC TCTCTGCTTA CTTTTGTCTG AGATGGCCTC AGGTGGTAAC TTTCTCACAG GCCTTGGCCA CAGATCTGAT CATTACAATT GCGTCAGCAG TGGAGGGCAA TGTCTCTATT CTGCCTGCCC GATCTTTACC AAAATTCAAG GCACCTGTTA CAGAGGGAAG GCCAAGTGCT GCAAGTGAGC TGGGAGTGAC CAGAAGAAAT GACGCAGAAG TGAAATGAAC

TT-3' (FRAG.NO: ) (SEQ. ID NO: 2475)

5'-CTGCAGTGGT AAAAAGATTC TATATCTGCT GTTTGATGAA TGCAGCACCC ACTAGCCACA TAGTGCTCGT GAGCACTTGC AATGCGGCTA GGGTGATTTC AATTAACCTA AAAGAGAACA GCCACAGGGA GCATGTGGCT GCCATATTGG ATGGTGCTGC TTTGAGAACA AAATGAGAGA AATGAAGCCT CTATTTACCT TGGTTGGCGG AACACATTGA AGGGACTCTG TATTGATACC AGGCTTCAAA CTTTGGGAAG TGTACTGGCC AACTTAAACA CATCCACAGG AGAATGAAGA GGTTTGGGAA GGGACCAGAA ACCAGGCATT GAGGACAATG AGAAGAGTTT TTCAAAAGTG GAATTACTGC AAAAAGTGGA AAAATAGCCT TTGGATGGAA GTTACTGATG AGACAATTTC CATCGGTGTG AAAGCCATCT TTCCAACAGA GATCTGCAAC ATGAGAATGT ACTGTCTCCT AGGGTAGCGA TGGCCTCTTG TATTAGTCCG CTCAGGCTAC CAGATTTATC GTTTAAACTG CCCATAAACA GACCAGGCAG TTTAAACAAC AGAAATTTAT TTCCTCGCAG TCCTGGAGGC AGGAAGTCTG CGATCAAGGT GGAAGCAGGG TTGGCTTCTT CTCAGGTGTC TGTCCTTGGC TGGTAGATGA CCGCCGCCTC CCTGGGTCCT CACATGGTCT TTCCTCTGTG TGTGTCTGTC CCAATCTCTT CTTATAAGGA TGCAAGTCTT ATGGATCAGA GCACACCCCA ATGACCGTGT TTAACTTGAA TCACCTCTTT AAAGTTTCTC TCTCCAAATA CAATCACCTC CTGAGGCACT GTTAGGGCTT CGACACAGGA ATTCTTTTCC TAGGGGATTC AGTTCAGTCC AAAACGCCTA CCAGTGGAGA CTTGCAACAT GGCGGCCTGC TGGTCCCTCG CCAGGAATAT CACAGGCGAC TGTTCCCTGT TGCATGGAAT AGAAGGCTAT TCCAGAGTAC TGTCTCTATT TATCAGATCT GGGATACTGG GAGAAGGGCA AAATAAAGTC CAAGTAGAAA AAAAAACTAT GAAAGTTTTA GAGAGTAACC ATAATTTCAG CCCGATGTGA AACGATCCTA GATTTCAGCT GAAATAGTGA TGTGGGAAGT GAGGGGGCCG GGATTCAAGG CAGAGGGAAC AGCGTAACTG AAGGCATGGA AGGAGGGAAG TGTAGGCTGT GTTTGAAGAG TGGCAGCTGC TTCCACATTT CTAAAACACA GGATGTGATT TTGGGGTGTG TTGAGACAAG GCAGAAAACT TGTTTGGAAA AATAACTTGA ATTCCCTGCA CATTTAAAAT CTCTCAGCAG AAGAAAACCC CACTCAGAAC CCCACTGTTC ATTCCTTGGC TTGTATTTGG SCACAGCTGG CATAGCCCCA GACTGAGTAA GCTCTTCAGA CACCTCATTT CATGAGTAGC CCCAAAGATC AATCATGGGC CAATTTCTTG GAAGAGAAGA CTCTCCGGTG TTTTGCAGTT ATTTGTTCTG CTTTCGCGAG ATGTTCTCAA ATCGTTGCAG CTACAAGCCA TGAGTCTGAA GTGTTTGTGT TCCCTCCTTA CAGGTGGTAA CTTTCTCACA GGCCTTGGCC ACAGATCTGA TCATTACAAT TGCGTCAGCA GTGGAGGGCA ATGTCTCTAT TCTGCCTGCC CGATCTTTAC CAAAATTCAA GGCACCTGTT ACAGAGGGAA GGCCAAGTGC TGCAAGTGAG CTGAGAGTGA CCAGAAGAAA TGACGCAGAA GTGAAATGAA CTTTTTATAA GCATTCTTTT AATAAAGGAA AATTGCTTTT GAAGTATACC TCCTTTGGGC CAAAATGAAT CTTGTGTCTC AATTGGAAGA GGTAAAGAAG TAGGGGGTTA GGGTGCATGG GTTGGAACGT GAGACAGGTC GAACCACAAA GCCTGCCTGG AAAAGGGGAG TGACGTCCTA GGCTTCAGTG ATGTCACCTC CACTTTGTTT

GATCCACAAA CCAACAGGTG ACTGATTTTG-3' (FRAG.NO: ) (SEQ. ID NO: 2474)

5'-GCTCAGCCTC CAAAGGAGCC AGCCTCTCCC CAGTTCCTGA AATCCTGAGT GTTGCCTGCC AGTCGCCATG AGAACTTCCT ACCTTCTGCT GTTTACTCTC TGCTTACTTT TGTCTGAGAT GGCCTCAGGT GGTAACTTTC TCACAGGCCT TGGCCACAGA EPI-109 179

TCTGATCATT ACAATTGCGT CAGCAGTGGA GGGCAATGTC TCTATTCTGC CTGCCCGATC TTTACCAAAA TTCAAGGCAC CTCTTACAGA GGGAAGGCCA AGTGCTGCAA GTGAGCTGGG AGTGACCAGA AGAAATGACG CAGAAGTGAA ATGAACTTTT

TATAAGCATT CTTTTAATAA AGGAAAATTG CTTTTGAAGT AT-3' (FRAG.NO: ) (SEQ. ID NO: 2472)

5 -CCGGGGC-3' (FRAG.NO: 1800) (SEQ. ID NO: 1811)

5'-GG GCCTGCBGGG CC-3' (FRAG.NO:1801) (SEQ. ED NO: 1812)

5 -GGCBGCB BGG-3' (FRAG.NO:1802) (SEQ. ED NO: 1813)

5'-GGG TCC TCB TGG CTG GGG-3' (FRAG. NO:1212) (SEQ. ID NO:1222)

5'-GCC TGG GCC TGC BGG GCC-3' (FRAG. NO:1213) (SEQ. ID NO:1223)

5'-GCT CTT GCC TGG BGT GGC TC-3' (FRAG. NO:1214) (SEQ. ID NO:1224)

5'-GCC CBG BGT CTT CCC TGG T-3' (FRAG. NO:1215) (SEQ. ID NO:1225)

5'-CCGGGGCTGC BGCBBCCTCB TCBGCTCTTG CCTGGBGTGG CTCBGCCTGG GCCTGCBGGG CCBCCBGGBG BBTGGCBGCB

BGGBTGGCGB GGGTCCTCBT GGCTGGGGTC BCBGBTCCTC TBGCTBGGCB GGGTGBCCBG BGBGGGC-3' (FRAG.NO:1803)

(SEQ. ID NO: 1814)

Human Defensin 2 Nucelic Acid and Antisense Oligonucleotide Fragments

5'-ATCCTTTAAG TCAATGGACT TTGCATCAGT CACACCATCT TTTGTTACTT TGGACTTCCC CAGCTATGTT CAATAATTAC TGTTCTTCCC TTGGGCCCCA TTGTAATGGC TACAGCCTCG ACAAAAAGTC TACACTTTGA AGCATTAAGG CTCGGACATC AGCACCAAAT TTTACATCTT TACCATCACT TCAAGTGAGG TGAGGAGCCA GTAGCCTGGA CACTGGTCTC ATCTGGTGAA AGACTGTGGG TAATGGAAGC ATTTCTGTGG GGTGCTGGCA GGACATGTGC ATGGCGAGGC AGGTCATCAG CAGCAAGTGA GAGCTGCCTC TTACTTTCTA AAGGTGACAT AGCAAATATA CAAAAAAAAA TAAATAAATT ATTAATTTAG GTAGAGCACA TAAAGGCTTT ATTTCATATT CCATTTCTCT GTATGCTTTC TTCACCAGGA AGAAATAGTT TTAGTGTCAG GAATGAATGA GTCTGCCCCT CAATTCCAGC CTGCTCAACA CACAAGGAAA CAAAGCCCTG ACAATCAGAG TGACTCCCTG GTGACTAAGC TCCCAGTCCT GGATGCATAT TTGTTTAGCA GTTCTGACAG CATTTGACCC AGCCCTCTCT CTGCATATCC CATCAGAACC TTCrTrTTTT TTTTTTTCTT GAGACTGAG TCTTGCTCTG TCGGAAGCGA CTCCTGTGCC TCAGCCTCCC AAATACCTGG AATTATAGGC GTAAGCCATC ATGCCTGGCT AATTTTTGTA TTTTTCATGG AGATGGGGTT TTGCCATGTT GGTCAAATTG GTCTCACACT CCTGACCTCA TGTGATCCAC CTGCCTCAGC CTCCCAAACT GCTGGGATGA CAGGTGTAAG CCACCATGCT AGGCTCAGAA ATTTCCTTTT ATAAAAATGT CATTAAGGAT CTTGGCTGCA CAATATCGTT ACCAGCTTCC TTTAAATCCA CTTCTGGCCT GCCAGGAATC AGGTTCTTCA GAACCTGACA TTTTAAATGA AGAGGTCAGG CAGTTCATGA GGAAAGCCTC ATTGTCCCCA TGTCTCTGTC ACTGCTGCAC CCCTGAGACA TCACAGACAT GGACACTGGG GCCTGCTTGT TTCTCAAACT GCCCTTAGAT CGAAAGAGGG AGGAACCAGG ATGAATGCCA CTCATTTTCC CAAGAAAGGC CCTCTCCTGA GTGCCCGGGA TGGGGCTCTG TCCATTGCCT GGGGCCGCCA ATTGCTACTC TGGGTTACGG AGGAAGGACA GGGTCCTGAG AGACACCAGA GACCTCACAC AGCCCTGAAA ACATGGGGCT CCTTCATAAG TGTTTCCCAT CACCAACAGG GAGACCACGT GGAGGCCTTG CAGCCCCACT CGGTGCTTCT CCACCAAATC CCAAGGGCAG TGACGCTGAC GTCTGTGGAA AGCAGAGAAA GCCCTGGCTC CCAAAGCCCT GAAGTCCCTG TGGAGCTGAC ATTCCCTGAG TGACGGTGTG AATGGAAGGA ACTCAAGTGC GGGTGGTAGG CCACCTCCTG GCCCAGGCCT GGGTGAACTC TGAGGGGACA CATGTAGTCA CAATCCCATC CTCCCATTCT CCTTCTCAGA GGAAGGAAGT GGGCATCCAT CTGCCTCATC TCTCTCCCGT GGGGAAGATG GGGAGTTTCA GGGGAACTTT CACATAAATT TCACCAGCTC AGATCTCCTG TGAGGATGGG GCCCACCATG CTCCCGGTGC TGCCAGAGGC CCTGAGCCCC TCCCAGGGTC CCTGGGTTTG AGCCAGCCCT GTATCATCCC CAGGAGCTGA ATGTCAGAGC AATGGATAGA ATTAGATGGA AAGAGCTCTC AATTTGACCT GAGACTGTCC CCAGATACTC AGGAAAAACA GGACGTCGCA CAGAGTGGGC AGCAGGTGAG TGGCAGGTTA TAGGTCCTGA GTTTGAGTTT GTTCTCACGT GAGACAGACC CAGCCCCTCA CTCCATTCAC ACACTGGGTT TTAAATGGTG CAAGATAGGA GCAATTTTCT GGTCCCAAGA GCAGGAGGAA GGGATTTTCT GGGGTTTCCT GAGTCCAGAT TTGCATAAGA TCTCCTGAGT GTGCATTGTT CTTTGAGGAC CATTCTCTGA CTCACCAGGT AAGTGGCTGA ATTCTAACCT CTGTAATGAG CATTGCACCC AATACCAGTT CTGAACTCTA CCTGGTGACC AGGGACCAGG ACCTTTATAA GGTGGAAGGC TTGATGTCCT CCCCAGACTC AGCTCCTGGT GAAGCTCCCA GCCATCAGCC ATGAGGGTCT TGTATCTCCT CTTCTCGTTC CTCTTCATAT TCCTGATGCC TCTTCCAGGT GAGATGGGCC AGGGAAATAG GAGGGTTGGC CAAATGGAAG AATGGCGTAG AAGTTCTCTG TCTCCTCTCA TTCCCCTCCA CCTATCTCTC CCTCATCCCT CTCTCTCCTT CCTCTCTCTG TGTGTCCCCT CCATCCTTTT CTCCTGCTTC TCTCTCTTCT TCCCTCTCTC TCTTTTTTCT GTCTTTCTTT TTCCTCTCTC CCTAGAGCAT GTCTTTCTTT CTTTCTCTTT CCTTTCTTCT ACCCACACTT TTAGACTGAA TGCCCTATTT AATTGAACAA AGCATTGCTT CCTTCAATAG AAAAGGAGTT TGAGAACCCA ATGGACACCT CACTCGTTCT TCTAAGCCAA TATGAAGGAG CCCAGTAGCT TGTAAATATC ATCTCTTCAC TGCTTTCCAT GCTACAACTG CTGAGACTAT GGTTGAAACC TGTTAGGTGA CTTTTTAAAT AAAAGGCAGA AATTTTGATT TTATCTAAAG AAAGTAGTAT AGAATGTCAT TTTCTAAATT TTTATATTTA AAGGGTAGAT ACTGCAACCT AGAGAATTCC AGATAATCTT AAGGCCCAGC CTATACTGTG AGAACTACTG CAGCAAGACA CTCTGCCTCC AGGACTTTTC TGATCAGAGG CCCTGAGAAC AGTCCCTGCC ACTAGGCCAC TGCAGGTTCA CAGGACAGGG TACAGCCCAT TGAAACCTAC TTTTAAACCT GGATGCCTAA CCTTCATTTT CTCCTTGATA TTATGAAAAT AAAATAAAAA CCATGAAAGG ATAAAAGAGG GAGAGTGGAA GGGAAGGATG GAGAAAGGGA AAAAGAAAAT TTGAGAGTAA ATCCTAAAAC AATTAATCTA ATAGATATCA TCTTGTGAAA TCCTCATTTT ACCAATCTTA TTTATGAGTC CTGGGTTTTG TGAGAACAAT GGGGTTCTGA GAGGCACCAG AGACCTCATG TTTTCCAAAA CCTAGAACAG TATAATGAAG GAAGGCGGGG AGGCAGGGAG GCAGGGAGGC AGGGAGGCAG GGAGGCGGGC AGGTGGGGAG GGAGGGACGG AAGGAGGGAG GGAGGGAGGG AGGGAGGGAG GGAGGGATAA AAAAAGAAGA ATGAGGTTGA AACCAGGACT TAGATATTAG AAACAAGCCA TTACAAAATT TATTTCTATG GTTAATTGTG GTTTTCAACT GTAAGTTACT TGGTGTTAAT TTCCTATTAA ACAATTTCAG TAAGTTGCAT CTTTTTATCC CATCTCAGGT CAAATACTTA ACAGACTAAA TGATTTGAAA AAGCAAAAGT TTACTGGCTT GTGTGTGTTA AAATGGAGGT ATGGTGGCTT TGATATTATC TTCTTGTGGT GGAGCTGAAT TCACAAGAGA TCGTTGCTGA GCTCCTACCA GACCCCACCT GGAGGCCCCA GTCACTCAGG AGAGATCAGG GTCTTTCACA ATCAGGTTCT ACAAAAATAA ACATCCCCCC AACCACAGCA GTGCCAGTTT CCATGTCAGA AACTTAGATC CAAATGACTG ACTCGCGTCT CATTATCATG ATGGAAAAGC CCAGGCTTGA GAAAGAAGCC CGCTGCGGAT TTACTCAAGG CGATACTGAC ACAGGGTTTG TGTTTTTCCA ACATGAGTTT TGAGTTCTTA CACGCTGTTT GCTCTTTTTG TGTGTTTTTT CCCTGTTAGG TGTTTTTGGT GGTATAGGCG ATCCTGTTAC CTGCCTTAAG AGTGGAGCCA TATGTCATCC AGTCTTTTGC CCTAGAAGGT ATAAACAAAT TGGCACCTGT GGTCTCCCTG GAACAAAATG CTGCAAAAAG CCATGAGGAG GCCAAGAAGC TGCTGTGGCT GATGCGGATT CAGAAAGGGC TCCCTCATCA GAGACGTGCG ACATGTAAAC CAAATTAAAC TATGGTGTCC AAAGATACGC AATCTTTATC CTAGTAATTG TGGTCATTGG GTGATGTTGG TTTGGGCAGG CCATCTCTAA TATCCTTGAA ACACCTTTTT CTGCTCTCCA GGAAGGGGTC AGGGCTGCCA CAGCGGGGCT TGGAGTGCTT bPI-109 180

TCCAGGGTCA CAGGCATCTG TATTCTTTGG ATTCCTTGAC CTTCCCCATT TATTCCCGGC ATTTTCCTAA AACGTGTGCT TTGCTCCTCC TGCATCCTCC CCTTGCATGC CCTCACCTAC CCCACATCTT CCCTAAAAAA AGCAAGCCCA ACTCAAAGAC CAGTTCCCTC ATGGAATCAT AGTGGATCTG CCAAGGGAGG GGATGCCCAG TCCTCTGTTC TTCACAAGAC TCCCTTCTTC TGGCTAAGGT TTCTTATGCA ATTAT GAATTCACAT TTCTCACCTT TTGATGTATT AAGAAAGTAT GGAGAAATAT ATCCTCTATC AAATTTTCAT GCCTTCAATA ATTTCTAATT CATCAGTCAG TGTTTTTCCA TCCTTTACTG TGATGATGCC CTTTCTTCCA AACTTTTTCA TTGCATCAGA GATGATGTTA CCAATTTCTT TGTCTCCATT TGCAGAAATT GTAGCAACCT GTGCAATTTC TTCAGGTTTG GTCACAGGTT TAGACTGCTT TTTAAGTTCA GCAATTACAG CATCAACAGC TAACATCACA CCTCTCTTCA TTTCCACTGG ATTAGCACCT TTGCTAACCT TCTGGAAGGC TTATTTGGAA ATAGAGCATA CCAGTACAGC AGCAGTGATA GTGCCATCCC CCAGTCTCTC CATTTGTGTT ATTGGCAACA TCTTGGACAA GTTTAGCTCC AATGCTTTTA TATTTATCCT TTAAGTCAAT TGACTTTGCA TCAGTCACAC CATCTTTTGT TACTTTGGGA CTTCCCCAGC TATGTTCAAT AATTACTGTT CTTCCCTTTG GCCCCATTGT AATGGCTACA GCATCGACAA AAAGTCTACA CTTTGAAGCA TTAAGGCTCA GACATCAGCA CCAAATTTTA CATCTTTACC ATCACTTCAA GTGAGGTGAG GAGCCAGTAG CCTGGACACT GGTCTCATCT GGTGAAAGAC TGTGGGTAAT GGAAGCATTT CTGTGGGGTG GTGGCAGGAC ATGTGCATGG TGAGGCAGGT CATCAGCAGC AAGTGAGAGC TGCCTCTTAC TTTCTAAAGG TGACATAGCA AGTATACAAA AAAAAATAAA ATATTAATTT AGGCAGAGCA CATAAAGGCT TTATTTCATA TTCCATTTCT CTGTATGCTT TCTTCACCAG GAAGAAATAG TTTTAGTGTC AGGAATGAAT GAGTCTGCCC CTCAATTCCA GCCTGCTCAG CACACAAGGA AACAAAGCCC TGACAATCAG AGTGACTCCC TGGTGACTAA GCTCCAGTCC TGGATGCATA TTTGTTTAGC AGTTCTGACA GCATCTGACC CAGCCCTCTC TTTGCATACC CCACCAGAAC CTTCTTTTTT TTTTΓTTTTC TTTGAGACTG AGTCTTGCTC TGTCGGAAGC GATTCCCGTG CCTCAGCCTC CCAAATACCT GGAATTATAG GCGTAAGCCA TCATGCCTGG CTAATTTTTG TATTTTTCAT GGAGATGGGG TTTTGCCATG TTGGTCAAAT TGGTCTCACA CTCCTGACCT CATGTGATCC ACCTGCCTCA GCCTCCCAAA GTGCTGGGAT GACAGGTGTA AGCCACCATG CTAGGCTCAG AAATTTCCTT TTATAAAAAT GTCATTAAGG ATCTTGGCTG CACAATATCG TTACCAGCTT CCTTTAAATC CACCTCTGGC CTGCCAGGAA TCAGGGTTCT TCAGAACCTG ACATTTTAAA TGAAGAGGTC AGGCAGGTCA TGAGGAAAGC CTCATTGTCC CCATGTCTCT GTCACTGCTG CACCCCTGAG ACATCACAGA CATGGACACT GGGGCCTGCT TGTTTCTCAA ACTGCCCTTA GATCGAAAGA GGGAGGAACC AGGATGAATG CCACTCATTT TCCCAAGAAA GGCCCTCTCC TGAGTGCCCG GGATGGGGCT CTGTCCATTG CCTGGGGCCG CCAATTGCTA CTCTGGGTTA CGGAAGAAGG ACAGGGTCCT GAGAGACACC AGAGACCTCA CACAGCCCTG AAAACATGGG GCTCCTTCAT AAGTGTTTCC CATCACCAAC AGGGAGACCA CGTGGAGGCC TTGCAGCCCT ACTCGGTGCT TCTCCACCAA ATCCCAAGGG CAGTGACGCT GACGTCTGTG GAAAGCAGAG AAAGCCCTGG CTCCCAAAGC CCTGAAGTCC TGTGGAGCTG ACATTCCCTG AGTGACGGTG TGAATGGAAG GAACTCAAGT GCGGGTGGTA GGCCACCTCC TGGCCCAGGC CTGGGTGAAC TCTGAGGGGA CACATGTAGT CACAATCCCA TCCTCCCATT CTCCTTCTCA GAGGAAGGAA GTGGGCATCC ATCTGCCTCA TCTCTCTCCC GTGGGGAAGA TGGGGAGTTT CAGGGGAACT TTCACATAAA TTTCACCAGC TCAGATCTCC TGTGAGGATG GGGCCCACCA TGCTCCCGGT GCTGCCAGAG GCCCTGAGCC CCTCCAGGGT CCCTGGGTTT GAGCCAGCCC TGTATCATCC CCAGGAGCTG AATGTCCGAA CAATGGATAG AATTAGATGG AAAGAGCTCT CAATTTGGCC TGAGACTGTC CCCAGATACT CAGGAAAAAC AGGACGTCGC ACAGAGTGGG CAGCAGGTGA GTGGCAGGTT ATAGGTCCTG AGTTTGAGTT TGTTCTCACG TGAGACAGAC CCAGCCCCTC ACTCCATTCA CACACTGGGT TTTAAATGGT GCAAGATAGG AGGAATTTTC TGGTCCCAAG AGCAGGAGGA AGGGATTTTC TGGGGTTTCC TGAGTCCAGA TTTGCATAAG ATCTCCTGAG TGTGCATTGT TCTTTGAGGA CCATTCTCTG ACTCACCAGG TAAGTGGCTG AATTCTAACC TCTGTAATGA GCATTGCACC CAATACCAGT TCTGAACTCT ACCTGGTGAC CAGGGACCAG GACCTTTATA AGGTGGAAGG CTTGATGTCC TCCCCAGACT CAGCTCCTGG TGAAGCTCCC AGCCATCAGC CATGAGGGTC TTGTATCTCC TCTTCTCGTT CCTCTTCATA TTCCTGATGC CTCTTCCAGG TGAGATGGGC CAGGGAAATA GGAGGGTTGG CCAAATGGAA GAATGGCGTA GAAGTTCTCT GTCTCCTCTC ATTCCCCTCC ACCTATCTCT CCCTCATCCC TCTCTCTCCT TCCTCTCTCT GTGTGTCCCC TCCATCCTTT TCTCCTGCTT CTCTCTCTTC TTCCCTCTCT CTCTTTTTTT CTGTCTTTCT TTTTCCTCTC TCCCTAGAGC ATGTCTTTCT TTCTTTCTCT TTCCTTTCTT CTACCCACAC TTTTAGACTG AGTAGACTGA ATGCCCTATT TAATTGAACC AAGCATTGCT TCCTTCAATA GAAAAGGAGT TTGAGAACCC AATGGACAAC TCACTCGTTC TTCTAAGCCA ATATGAAGGA GCCCAGTAGT TTGTAAATAT CATCTCTTCA CTGCTTTCCA TGCTACAACT GCTGAGACTA TGGTTGAAAC CTGTTAGGTG ACTTTTTAAA TAAAAGGCAG AAATTTTGAT TTTATCTAAA GAAAGTAGTA TAGAATGTCA TTTTCTAAAT TTTTATATTT AAAGAGTAGA TACTGCAACC TAGAGAATTC CAGATAATCT TAAGGCCCAG CCTATACTGT GAGAACTACT GCAGCAGACA CTCTGCCCCC AGGACTTTTC TGATCAGAGG CCCTGAGAAC AGTCCCTGCC ACTAGGCCAC TGCAGGTTCA CAGGACAGGG ACAGCCCATT GAAACCAACT TTTAAACCTG GATGCCTAAC CTTCATTTTC TCCTTGATAT TATGAAAATA AAATAAAAAC CATGAAAGGA TAAAAGAGGG AGAGTGGAAG GGAAGGATGG AGAAAGGGAA AAAGAAAATT TGAGAGTAAA TCCTAAAACA ATTAATCTAA TAGATATCAT CTTGTGAAAT CCTCATTTTA CCAATCTTAT TTATGAGTCC TGGGTTTTGT GAGAACAATG GGGTTCTGAG AGGCACCAGA GACCTCATAT TTTCCAAAAC CTAGAACAGT ATAATGAAGG AAGGAGGGAA GGAGGGAGGG AGGGAGGGAA GGAGGGAAGG AGGGAGGGAG GGAGGGAAAC AAAAAGAAGA ATGAGGTTGA AACCAGGACT TAGATATTAG AAACAAGCCA TTACAAAATT TATTTCTATG GTTAATTGTG GTrTTCAACT GTAAGTTACT TGGTGTTAAT TTCCTATTAA ACAATTTCAG TAAGTTGCAT CTTTTTTATC CCATCTCAGA TCAAATACTT AACAGACTAA ATGATTTGAA AAAGCAAAAG TTTACTGGCT TGTGTGTGTT AAAATGGAGG TATGGTGGCT TTGATATTAT CTTCTTGTGG TGGAGCTGAA TTCACAAGAG ATCGTTGCTG AGCTCCTGCC AGACCCCACC TGGAGGCCCC AGTCACTCAG GAGAGATCAG GGTCTTTCAC AATCAGGTTC TACAAAAATA AACATCCCCC AAACCACAGC AGTGCCAGTT TCCATGTCAG AAACTTAGAT CCAAATGACT GACTCGCGTC TCATTATCAT GATGGAAAAG CCCAGGCTTG AGAAAGAAGC CCGCTGCGGA TTTACTCAAG GCGATACTGA CACAGGGTTT GTGTTTTTCC AACATGAGTT TTGAGTTCTT ACACGCTGTT TGCTCTTTTT GTGTGTTTTT TCCCTGTTAG GTGTTTTTGG TGGTATAGGC GATCCTGTTA CCTGCCTTAA GAGTGGAGCC ATATGTCATC CAGTCTTTTG CCCTAGAAGG TATAAACAAA TTGGCACCTG TGGTCTCCCT GGAACAAAAT GCTGCAAAAA GCCATGAGGA GGCCAAGAAG CTGCTGTGGC TGATGCGGAT TCAGAAAGGG CTCCCTCATC AGAGACGTGC GACATGTAAA CCAAATTAAA CTATGGTGTC CAAAGATACG CAATCTTTAT CCTAGTAATT GTGGTCATTG GGTGATGTTG GTTTGGGCAG GCCATCTCTA ATATCCTTGA AACACCTTTT

TCTGCTCTCC AGGAAGGGGT CAGGGCTGCC ACAGCGGGGC TTGGAGTGC-3' (FRAG. NO: ) (SEQ. ID NO:2473)

5'-GAATTCACAT TTCTCACCTT TTGATGTATT AAGAAAGTAT GGAGAAATAT ATCCTCTATC AAATTTTCAT GCCTTCAATA ATTTCTAATT CATCAGTCAG TGTTTTTCCA TCCTTTACTG TGATGATGCC CTTTCTTCCA AACTTTTTCA TTGCATCAGA GATGATGTTA CCAATTTCTT TGTCTCCATT TGCAGAAATT GTAGCAACCT GTGCAATTTC TTCAGGTTTG GTCACAGGTT TAGACTGCTT TTTAAGTTCA GCAATTACAG CATCAACAGC TAACATCACA CCTCTCTTGA TTTCCACTGG ATTAGCACCT TTGCTAACCT TCTGGAAGGC TTATTTGGAA ATAGAGCATA CCAGTACAGC AGCAGTGATA GTGCCATCCC CCAGTCTCTC bPl-109 181

CATTTGTGTT ATTGGCAACA TCTTGGACAA GTTTAGCTCC AATGCTTTTA TATTTATCCT TTAAGTCAAT TGACTTTGCA TCAGTCACAC CATCTTTTGT TACTTTGGGA CTTCCCCAGC TATGTTCAAT AATTACTGTT CTTCCCTTTG GCCCCATTCT AATGGCTACA GCATCGACAA AAAGTCTACA CTTTGAAGCA TTAAGGCTCA GACATCAGCA CCAAATTTTA CATCTTTACC ATCACTTCAA GTGAGGTGAG GAGCCAGTAG CCTGGACACT GGTCTCATCT GGTGAAAGAC TGTGGGTAAT GGAAGCATTT CTGTGGGGTG GTGGCAGGAC ATGTGCATGG TGAGGCAGGT CATCAGCAGC AAGTGAGAGC TGCCTCTTAC TTTCTAAAGG TGACATAGCA AGTATACAAA AAAAAATAAA ATATTAATTT AGGCAGAGCA CATAAAGGCT TTATTTCATA TTCCATTTCT CTGTATGCTT TCTTCACCAG GAAGAAATAG TTTTAGTGTC AGGAATGAAT GAGTCTGCCC CTCAATTCCA GCCTGCTCAG CACACAAGGA AACAAAGCCC TGACAATCAG AGTGACTCCC TGGTGACTAA GCTCCAGTCC TGGATGCATA TTTGTTTAGC AGTTCTGACA GCATCTGACC CAGCCCTCTC TTTGCATACC CCACCAGAAC CTTCTTTTTT TTTTTTTTTC TTTGAGACTG AGTCTTGCTC TGTCGGAAGC GATTCCCGTG CCTCAGCCTC CCAAATACCT GGAATTATAG GCGTAAGCCA TCATGCCTGG CTAATTTTTG TATTTTTCAT GGAGATGGGG TTTTGCCATG TTGGTCAAAT TGGTCTCACA CTCCTGACCT CATGTGATCC ACCTGCCTCA GCCTCCCAAA GTGCTGGGAT GACAGGTGTA AGCCACCATG CTAGGCTCAG AAATTTCCTT TTATAAAAAT GTCATTAAGG ATCTTGGCTG CACAATATCG TTACCAGCTT CCTTTAAATC CACCTCTGGC CTGCCAGGAA TCAGGGTTCT TCAGAACCTG ACATTTTAAA TGAAGAGGTC AGGCAGGTCA TGAGGAAAGC CTCATTGTCC CCATGTCTCT GTCACTGCTG CACCCCTGAG ACATCACAGA CATGGACACT GGGGCCTGCT TGTTTCTCAA ACTGCCCTTA GATCGAAAGA GGGAGGAACC AGGATGAATG CCACTCATTT TCCCAAGAAA GGCCCTCTCC TGAGTGCCCG GGATGGGGCT CTGTCCATTG CCTGGGGCCG CCAATTGCTA CTCTGGGTTA CGGAAGAAGG ACAGGGTCCT GAGAGACACC AGAGACCTCA CACAGCCCTG AAAACATGGG GCTCCTTCAT AAGTGTTTCC CATCACCAAC AGGGAGACCA CGTGGAGGCC TTGCAGCCCT ACTCGGTGCT TCTCCACCAA ATCCCAAGGG CAGTGACGCT GACGTCTGTG GAAAGCAGAG AAAGCCCTGG CTCCCAAAGC CCTGAAGTCC TGTGGAGCTG ACATTCCCTG AGTGACGGTG TGAATGGAAG GAACTCAAGT GCGGGTGGTA GGCCACCTCC TGGCCCAGGC CTGGGTGAAC TCTGAGGGGA CACATGTAGT CACAATCCCA TCCTCCCATT CTCCTTCTCA GAGGAAGGAA GTGGGCATCC ATCTGCCTCA TCTCTCTCCC GTGGGGAAGA TGGGGAGTTT CAGGGGAACT TTCACATAAA TTTCACCAGC TCAGATCTCC TGTGAGGATG GGGCCCACCA TGCTCCCGGT GCTGCCAGAG GCCCTGAGCC CCTCCAGGGT CCCTGGGTTT GAGCCAGCCC TGTATCATCC CCAGGAGCTG AATGTCCGAA CAATGGATAG AATTAGATGG AAAGAGCTCT CAATTTGGCC TGAGACTGTC CCCAGATACT CAGGAAAAAC AGGACGTCGC ACAGAGTGGG CAGCAGGTGA GTGGCAGGTT ATAGGTCCTG AGTTTGAGTT TGTTCTCACG TGAGACAGAC CCAGCCCCTC ACTCCATTCA CACACTGGGT TTTAAATGGT GCAAGATAGG AGGAATTTTC TGGTCCCAAG AGCAGGAGGA AGGGATTTTC TGGGGTTTCC TGAGTCCAGA TTTGCATAAG ATCTCCTGAG TGTGCATTGT TCTTTGAGGA CCATTCTCTG ACTCACCAGG TAAGTGGCTG AATTCTAACC TCTGTAATGA GCATTGCACC CAATACCAGT TCTGAACTCT ACCTGGTGAC CAGGGACCAG GACCTTTATA AGGTGGAAGG CTTGATGTCC TCCCCAGACT CAGCTCCTGG TGAAGCTCCC AGCCATCAGC CATGAGGGTC TTGTATCTCC TCTTCTCGTT CCTCTTCATA TTCCTGATGC CTCTTCCAGG TGAGATGGGC CAGGGAAATA GGAGGGTTGG CCAAATGGAA GAATGGCGTA GAAGTTCTCT GTCTCCTCTC ATTCCCCTCC ACCTATCTCT CCCTCATCCC TCTCTCTCCT TCCTCTCTCT GTGTGTCCCC TCCATCCTTT TCTCCTGCTT CTCTCTCTTC TTCCCTCTCT CTCTTTTTTT CTGTCTTTCT TTTTCCTCTC TCCCTAGAGC ATGTCTTTCT TTCTTTCTCT TTCCTTTCTT CTACCCACAC TTTTAGACTG AGTAGACTGA ATGCCCTATT TAATTGAACC AAGCATTGCT TCCTTCAATA GAAAAGGAGT TTGAGAACCC AATGGACAAC TCACTCGTTC TTCTAAGCCA ATATGAAGGA GCCCAGTAGT TTGTAAATAT CATCTCTTCA CTGCTTTCCA TGCTACAACT GCTGAGACTA TGGTTGAAAC CTGTTAGGTG ACTTTTTAAA TAAAAGGCAG AAATTTTCAT TTTATCTAAA GAAAGTAGTA TAGAATGTCA TTTTCTAAAT TTTTATATTT AAAGAGTAGA TACTGCAACC TAGAGAATTC CAGATAATCT TAAGGCCCAG CCTATACTGT GAGAACTACT GCAGCAGACA CTCTGCCCCC AGGACTTTTC TGATCAGAGG CCCTGAGAAC AGTCCCTGCC ACTAGGCCAC TGCAGGTTCA CAGGACAGGG ACAGCCCATT GAAACCAACT TTTAAACCTG GATGCCTAAC CTTCATTTTC TCCTTGATAT TATGAAAATA AAATAAAAAC CATGAAAGGA TAAAAGAGGG AGAGTGGAAG GGAAGGATGG AGAAAGGGAA AAAGAAAATT TGAGAGTAAA TCCTAAAACA ATTAATCTAA TAGATATCAT CTTGTGAAAT CCTCATTTTA CCAATCTTAT TTATGAGTCC TGGGTTTTGT GAGAACAATG GGGTTCTGAG AGGCACCAGA GACCTCATAT TTTCCAAAAC CTAGAACAGT ATAATGAAGG AAGGAGGGAA GGAGGGAGGG AGGGAGGGAA GGAGGGAAGG AGGGAGGGAG GGAGGGAAAC AAAAAGAAGA ATGAGGTTGA AACCAGGACT TAGATATTAG AAACAAGCCA TTACAAAATT TATTTCTATG GTTAATTGTG GTTTTCAACT GTAAGTTACT TGGTGTTAAT TTCCTATTAA ACAATTTCAG TAAGTTGCAT CTTTTTTATC CCATCTCAGA TCAAATACTT AACAGACTAA ATGATTTGAA AAAGCAAAAG TTTACTGGCT TGTGTGTGTT AAAATGGAGG TATGGTGGCT TTGATATTAT CTTCTTGTGG TGGAGCTGAA TTCACAAGAG ATCGTTGCTG AGCTCCTGCC AGACCCCACC TGGAGGCCCC AGTCACTCAG GAGAGATCAG GGTCTTTCAC AATCAGGTTC TACAAAAATA AACATCCCCC AAACCACAGC AGTGCCAGTT TCCATGTCAG AAACTTAGAT CCAAATGACT GACTCGCGTC TCATTATCAT GATGGAAAAG CCCAGGCTTG AGAAAGAAGC CCGCTGCGGA TTTACTCAAG GCGATACTGA CACAGGGTTT GTGTTTTTCC AACATGAGTT TTGAGTTCTT ACACGCTGTT TGCTCTTTTT GTGTGTTTTT TCCCTGTTAG GTGTTTTTGG TGGTATAGGC GATCCTGTTA CCTGCCTTAA GAGTGGAGCC ATATGTCATC CAGTCTTTTG CCCTAGAAGG TATAAACAAA TTGGCACCTG TGGTCTCCCT GGAACAAAAT GCTGCAAAAA GCCATGAGGA GGCCAAGAAG CTGCTGTGGC TGATGCGGAT TCAGAAAGGG CTCCCTCATC AGAGACGTGC GACATGTAAA CCAAATTAAA CTATGGTGTC CAAAGATACG CAATCTTTAT CCTAGTAATT GTGGTCATTG GGTGATGTTG GTTTGGGCAG GCCATCTCTA ATATCCTTGA AACACCTTTT TCTGCTCTCC AGGAAGGGGT CAGGGCTGCC ACAGCGGGGC

TTGGAGTGC-3' (FRAG. NO: ) (SEQ. ID NO:2476)

5'-ATCCTTTAAG TCAATGGACT TTGCATCAGT CACACCATCT TTTGTTACTT TGGACTTCCC CAGCTATGTT CAATAATTAC TGTTCTTCCC TTGGGCCCCA TTGTAATGGC TACAGCCTCG ACAAAAAGTC TACACTTTGA AGCATTAAGG CTCGGACATC AGCACCAAAT TTTACATCTT TACCATCACT TCAAGTGAGG TGAGGAGCCA GTAGCCTGGA CACTGGTCTC ATCTGGTGAA AGACTGTGGG TAATGGAAGC ATTTCTGTGG GGTGCTGGCA GGACATGTGC ATGGCGAGGC AGGTCATCAG CAGCAAGTGA GAGCTGCCTC TTACTTTCTA AAGGTGACAT AGCAAATATA CAAAAAAAAA TAAATAAATT ATTAATTTAG GTAGAGCACA TAAAGGCTTT ATTTCATATT CCATTTCTCT GTATGCTTTC TTCACCAGGA AGAAATAGTT TTAGTGTCAG GAATGAATGA GTCTGCCCCT CAATTCCAGC CTGCTCAACA CACAAGGAAA CAAAGCCCTG ACAATCAGAG TGACTCCCTG GTGACTAAGC TCCCAGTCCT GGATGCATAT TTGTTTAGCA GTTCTGACAG CATTTGACCC AGCCCTCTCT CTGCATATCC CATCAGAACC

TTCTTTTTTT TTTΓΓΓTCTT TGAGACTGAG TCTTGCTCTG TCGGAAGCGA CTCCTGTGCC TCAGCCTCCC AAATACCTGG

AATTATAGGC GTAAGCCATC ATGCCTGGCT AATTTTTGTA TTTTTCATGG AGATGGGGTT TTGCCATGTT GGTCAAATTG GTCTCACACT CCTGACCTCA TGTGATCCAC CTGCCTCAGC CTCCCAAACT GCTGGGATGA CAGGTGTAAG CCACCATGCT AGGCTCAGAA ATTTCCTTTT ATAAAAATGT CATTAAGGAT CTTGGCTGCA CAATATCGTT ACCAGCTTCC TTTAAATCCA CTTCTGGCCT GCCAGGAATC AGGTTCTTCA GAACCTGACA TTTTAAATGA AGAGGTCAGG CAGTTCATGA GGAAAGCCTC EPI-109 182

ATTGTCCCCA TGTCTCTGTC ACTGCTGCAC CCCTGAGACA TCACAGACAT GGACACTGGG GCCTGCTTGT TTCTCAAACT GCCCTTAGAT CGAAAGAGGG AGGAACCAGG ATGAATGCCA CTCATTTTCC CAAGAAAGGC CCTCTCCTGA GTGCCCGGGA TGGGGCTCTG TCCATTGCCT GGGGCCGCCA ATTGCTACTC TGGGTTACGG AGGAAGGACA GGGTCCTGAG AGACACCAGA GACCTCACAC AGCCCTGAAA ACATGGGGCT CCTTCATAAG TGTTTCCCAT CACCAACAGG GAGACCACGT GGAGGCCTTG CAGCCCCACT CGGTGCTTCT CCACCAAATC CCAAGGGCAG TGACGCTGAC GTCTGTGGAA AGCAGAGAAA GCCCTGGCTC CCAAAGCCCT GAAGTCCCTG TGGAGCTGAC ATTCCCTGAG TGACGGTGTG AATGGAAGGA ACTCAAGTGC GGGTGGTAGG CCACCTCCTG GCCCAGGCCT GGGTGAACTC TGAGGGGACA CATGTAGTCA CAATCCCATC CTCCCATTCT CCTTCTCAGA GGAAGGAAGT GGGCATCCAT CTGCCTCATC TCTCTCCCGT GGGGAAGATG GGGAGTTTCA GGGGAACTTT CACATAAATT TCACCAGCTC AGATCTCCTG TGAGGATGGG GCCCACCATG CTCCCGGTGC TGCCAGAGGC CCTGAGCCCC TCCCAGGGTC CCTGGGTTTG AGCCAGCCCT GTATCATCCC CAGGAGCTGA ATGTCAGAGC AATGGATAGA ATTAGATGGA AAGAGCTCTC AATTTGACCT GAGACTGTCC CCAGATACTC AGGAAAAACA GGACGTCGCA CAGAGTGGGC AGCAGGTGAG TGGCAGGTTA TAGGTCCTGA GTTTGAGTTT GTTCTCACGT GAGACAGACC CAGCCCCTCA CTCCATTCAC ACACTGGGTT TTAAATGGTG CAAGATAGGA GCAATTTTCT GGTCCCAAGA GCAGGAGGAA GGGATTTTCT GGGGTTTCCT GAGTCCAGAT TTGCATAAGA TCTCCTGAGT GTGCATTGTT CTTTGAGGAC CATTCTCTGA CTCACCAGGT AAGTGGCTGA ATTCTAACCT CTGTAATGAG CATTGCACCC AATACCAGTT CTGAACTCTA CCTGGTGACC AGGGACCAGG ACCTTTATAA GGTGGAAGGC TTGATGTCCT CCCCAGACTC AGCTCCTGGT GAAGCTCCCA GCCATCAGCC ATGAGGGTCT TGTATCTCCT CTTCTCGTTC CTCTTCATAT TCCTGATGCC TCTTCCAGGT GAGATGGGCC AGGGAAATAG GAGGGTTGGC CAAATGGAAG AATGGCGTAG AAGTTCTCTG TCTCCTCTCA TTCCCCTCCA CCTATCTCTC CCTCATCCCT CTCTCTCCTT CCTCTCTCTG TGTGTCCCCT CCATCCTTTT CTCCTGCTTC TCTCTCTTCT TCCCTCTCTC TCTTTTTTCT GTCTTTCTTT TTCCTCTCTC CCTAGAGCAT GTCTTTCTTT CTTTCTCTTT CCTTTCTTCT ACCCACACTT TTAGACTGAA TGCCCTATTT AATTGAACAA AGCATTGCTT CCTTCAATAG AAAAGGAGTT TGAGAACCCA ATGGACACCT CACTCGTTCT TCTAAGCCAA TATGAAGGAG CCCAGTAGCT TGTAAATATC ATCTCTTCAC TGCTTTCCAT GCTACAACTG CTGAGACTAT GGTTGAAACC TGTTAGGTGA CTTTTTAAAT AAAAGGCAGA AATTTTGATT TTATCTAAAG AAAGTAGTAT AGAATGTCAT TTTCTAAATT TTTATATTTA AAGGGTAGAT ACTGCAACCT AGAGAATTCC AGATAATCTT AAGGCCCAGC CTATACTGTG AGAACTACTG CAGCAAGACA CTCTGCCTCC AGGACTTTTC TGATCAGAGG CCCTGAGAAC AGTCCCTGCC ACTAGGCCAC TGCAGGTTCA CAGGACAGGG TACAGCCCAT TGAAACCTAC TTTTAAACCT GGATGCCTAA CCTTCATTTT CTCCTTGATA TTATGAAAAT AAAATAAAAA CCATGAAAGG ATAAAAGAGG GAGAGTGGAA GGGAAGGATG GAGAAAGGGA AAAAGAAAAT TTGAGAGTAA ATCCTAAAAC AATTAATCTA ATAGATATCA TCTTGTGAAA TCCTCATTTT ACCAATCTTA TTTATGAGTC CTGGGTTTTG TGAGAACAAT GGGGTTCTGA GAGGCACCAG AGACCTCATG TTTTCCAAAA CCTAGAACAG TATAATGAAG GAAGGCGGGG AGGCAGGGAG GCAGGGAGGC AGGGAGGCAG GGAGGCGGGC AGGTGGGGAG GGAGGGACGG AAGGAGGGAG GGAGGGAGGG AGGGAGGGAG GGAGGGATAA AAAAAGAAGA ATGAGGTTGA AACCAGGACT TAGATATTAG AAACAAGCCA TTACAAAATT TATTTCTATG GTTAATTGTG GTTTTCAACT GTAAGTTACT TGGTGTTAAT TTCCTATTAA ACAATTTCAG TAAGTTGCAT CTTTTTATCC CATCTCAGGT CAAATACTTA ACAGACTAAA TGATTTGAAA AAGCAAAAGT TTACTGGCTT GTGTGTGTTA AAATGGAGGT ATGGTGGCTT TGATATTATC TTCTTGTGGT GGAGCTGAAT TCACAAGAGA TCGTTGCTGA GCTCCTACCA GACCCCACCT GGAGGCCCCA GTCACTCAGG AGAGATCAGG GTCTTTCACA ATCAGGTTCT ACAAAAATAA ACATCCCCCC AACCACAGCA GTGCCAGTTT CCATGTCAGA AACTTAGATC CAAATGACTG ACTCGCGTCT CATTATCATG ATGGAAAAGC CCAGGCTTGA GAAAGAAGCC CGCTGCGGAT TTACTCAAGG CGATACTGAC ACAGGGTTTG TGTTTTTCCA ACATGAGTTT TGAGTTCTTA CACGCTGTTT GCTCTTTTTG TGTGTTTTTT CCCTGTTAGG TGTTTTTGGT GGTATAGGCG ATCCTGTTAC CTGCCTTAAG AGTGGAGCCA TATGTCATCC AGTCTTTTGC CCTAGAAGGT ATAAACAAAT TGGCACCTGT GGTCTCCCTG GAACAAAATG CTGCAAAAAG CCATGAGGAG GCCAAGAAGC TGCTGTGGCT GATGCGGATT CAGAAAGGGC TCCCTCATCA GAGACGTGCG ACATGTAAAC CAAATTAAAC TATGGTGTCC AAAGATACGC AATCTTTATC CTAGTAATTG TGGTCATTGG GTGATGTTGG TTTGGGCAGG CCATCTCTAA TATCCTTGAA ACACCTTTTT CTGCTCTCCA GGAAGGGGTC AGGGCTGCCA CAGCGGGGCT TGGAGTGCTT TCCAGGGTCA CAGGCATCTG TATTCTTTGG ATTCCTTGAC CTTCCCCATT TATTCCCGGC ATTTTCCTAA AACGTGTGCT TTGCTCCTCC TGCATCCTCC CCTTGCATGC CCTCACCTAC CCCACATCTT CCCTAAAAAA AGCAAGCCCA ACTCAAAGAC CAGTTCCCTC ATGGAATCAT AGTGGATCTG CCAAGGGAGG GGATGCCCAG TCCTCTGTTC TTCACAAGAC TCCCTTCTTC TGGCTAAGGT TTCTTATGCA ATTAT GAATTCCCTG TAAGCCCTGT TACAGGGGCT GCACCCCAGA TACAACCTGA CCTGTGTCCA AGGCGGGCAA CTCAACCCTT AGATATTGAA TGGGTCCCAT GGCACCAATG CTTAAACACC AGCAGCCCTC ACAACCACAG ATCGTGTTTT AAGGATGAGG AGGTAGTTCT CTGGATGCAC AGGCTTCAAT CCAAATGGGC TCATGACGCC GCAGCACACA CCCAGTCTGC AGCCTGAAGA GTTGGAGCAT TGCATTCACA GAAAGCATCC AGACATGATC ATGGGCTCAG GGATACACCT GTTCTCCGAT GTGTACCAGT GAAGGATGGA AACTCCTATG CCTCCCAGAA AGCACCACTC AAGCTTTTGC TGAATGCTTC TCTGAAGGCC CACAAGGCTG AGAGGCTGTG CAACACCAGC AGTAAAGTGA ATGCCCAGAC TCCCACCTCC TTTCTTGGGT GGCCATCTGG AAAGGCCACT CCCACCCTGA TGGCTAATGC CTCAGACCAG TTCTTGGCCC AGATGATCCT AGACAATTGT TTAAGCTTAA ACTGTTCATT GGCCAAGCAA ACAGGTGATA GTACCTCTGG GGAACCACAT GCCGCGTGTA CATCCAGATC TCAGGAGAAC CCAAAAATGT CTGTTCCACA TAGCAACAGA AGCCCAGGTA GCACTCAGTC TCACCTGGGT GTTCTCCAAC ATCCCAGCTC AGCCAAATGG CTTTCATTAG TTTTTATGGT TAGACCCCAG GTCCTCGGGA CACTGCTTTA GAAACACATT CCAAATCCTC CTCTGTGTGC AGGTGGCATT CCTATCCCAA TCTCTTTGCA GGGCGTATAC TGTGATACGC AGCCAGGCTG TCCCAGAGGC CTTAAATATT CCCTTGGTGC AGGTAGTTCA GCTTAGCCAC AGCCAATGCA TCACAGGGTC AACTGTGTTA GGAGCCATTG AGAATCCATA GTTGGTTGCT GCCTGGGCCT GGCCAGGGCT GACCAAGGTA GATGAGAGGT TCCTCTGTGG AGTTCTACTT TAACCTCACC TTCCCACCAA ATTTCTCAAC TGTCCTTGCC ACCACAATTA TTTAATGGAC CCAACAGAAA GTAACCCCGG AAATTAGGAC ACCTCATCCC AAAAGACCTT TAAATAGGGG AAGTCCACTT GTGCACGGCT GCTCCTTGCT ATAGAAGACC TGGGACAGAG GACTGCTGTC TGCCCTCTCT GGTCACCCTG CCTAGCTAGA GGATCTGTAA GTACTACAAA ACTTAAACTT TACACTGAGT TTTCATCATT GAAGCTATGC CTCCAATCTG ACCTCTGACT GTGGGGCCGC CCCAGAGGGA CCCAGCGGGT GAATCCCTGC TAGGAACGTC TGTCCGGACC TCTGGTGACT GCTGGGGACG ATGGCTTCCA GCTAACTTAA TAGAGAAACT CAAGCAGTTT CCTTCTAAAT ACACATGTCA CATGTCCTGG TTGACATGTC CAGTAAGAAG ACTATCACAG GTCTTTGGAA CATTCTTTTG AGAGAAACCT ATTTAGGTCC TTGGTCTGTT TTTCAATCAG GTTGTTTGAT TTTTGCTATT GAGTTGTTGG AATTCCTTAT GTATTCAGAT ATTTGCCCCT TCTGCCATGT AGGTTTTGCA AATATTTTCT CTCATTTTCT GGGTTATCTT TTCACTCGGT TGATTGTTTC CTTTGCTGTG CAGATGCTTT AGCGTTAAAT GAAGCCACAC TTGTCTATTT TCCCTTTTAT TGCCTGTGCC TTTGGTGTCA TAGCCAAGAA ATCATTACCT ACATCAATGT CAAAAGCTTT ATCCTTCTAT ACACTTCTAG TAGTTTATGG TTTCAGTTGT TACATTTAGG TTTTCAATTC ATTCTGAGTT GATGTTCCTA EPI-109 183

CATGGTGTGA GATAAAGATT TAAATACATA CATATATAAA ATCATGAGGT AGTGTACACT ATAAATATAC AATTGTTAAT TGTTACTCAA GTCTAAGTAG AGGTGGAAAT AATAAACTTT CTTTTTTTTA CTTAAACCAC TCTGTGTCAC TGAGCTGATT TCACCTTTAG CCTGATAAAA TCATTGTCCT CTCCACCCTG ATTCCTACAG GAGACTACTC ACCCCATAAC CTCAAAAACC TCTTCATGAG GATGGTAAGT CACCTGAATC CTGAAGTGAA TTACTCGCTA TTCCATTGGA ACTCATATAG GACACCAGAA TCTAGACCTC CAGAGAACAG CAGGACCCAT CTTCAGAAAA TAAGAAGCAT TTGTTCCCTG AGCCTGTTGA ATCAAAGTGC AATTTCTATT CTTTTTGGAA TGTTAAAAAG TGAATCATAA TATTTAAGCA GGTGAACCCA CGAGTAACAT AGCAGGGTCT TTCTTGTCAT TATTAGCTCC AACCTAGCAC AGACATTAAA GGTACAGATG TATACTAGCA TGAAACTGGG AGAACAGGAG CATTCGAGCA ACCTTGAGAC CAATGGGCCT CTCTTATAAA ATGCACACCT CCTCTCACTG AGATTGAGGA AGGTTTCTTG TCTCCGAGCC TTCTCCCAGT AGAGCTATAA ATCCAGGCTG GCTCCTCCCT CCCCACACAG CTGCTCCTGC TCTCCCTCCT CCAGGTGACC CCAGCCATGA GGACCCTCGC CATCCTTGCT GCCATTCTCC TGGTGGCCCT GCAGGCCCAG GCTGAGCCAC TCCAGGCAAG AGCTGATGAG GTTGCTGCAG CCCCGGAGCA GATTGCAGCG GACATCCCAG AAGTGGTTGT TTCCCTTGCA TGGGACGAAA GCTTGGCTCC AAAGCATCCA GGTGAGAGAG GCAGGCATGC AGAGCTGCTA AGTCTAGAGG GAAGGACGGG AGAGAGGTTC CAGAGTTGGG TCTCAGCAGT CTATGTCACT GAGGTGGCTT CACTTAGAAT CTCTGGGCAT TGATTTTCTC ATCTAGAAAT TGAACAGAGA GCCAAATAAA CCTGAGAAAC TTTATTTCTC CAAAGACTTG ATTCCAAGAA ACATCTGTGA AATTCACTAA GTTTAAGATA TGAAGAGACA GACTAGTTAT TTCTGGATCT AAACAAGTAG ACTTAGTTGT AAAGAGAACA TTTTACTCTA TCTACAGAAG AGCTTTTAAA AACTGCAGCC AAGCCTGAGG GTAAGTTCAG GTGTGTGTGT GATGGGGCAG GAATGCAAAA ATGAGAGCAA AGGAGAATGA GTCTCAAATT CTGTGTGACA AGCACTGCTC TGCGTGTTTA TTCCTATCGA CTGAGGTTGT TCGTGCTACC GGCTGCAATG CAGCCAGCAT CACCTGTCAG CTAGCATGTG ACTTCCCCGA GATTCTTTTT CTTACCCACT GCTAACTCCA TACTCAATTT CTCATGCTCT CCCTGTCCCA GGCTCAAGGA AAAACATGGA CTGCTATTGC AGAATACCAG CGTGCATTGC AGGAGAACGT CGCTATGGAA CCTGCATCTA CCAGGGAAGA CTCTGGGCAT TCTGCTGCTG AGCTTGCAGA AAAAGAAAAA TGAGCTCAAA ATTTGCTTTG AGAGCTACAG GGAATTGCTA TTACTCCTGT ACCTTCTGCT CAATTTCCTT TCCTCATCTC AAATAAATGC CTTGTTACAA GATTTCTGTG TTTCCACCTC TTTAATGTGT GATATGTGTC

TGTGTCAAGA CACTTGGGAT ACACGTACCA AAACGCAAAA TCAAATTTTT GAACAATATA-3 ' (FRAG. NO: ) (SEQ. ID

NO:2473)

Human Defensin 3 Nucleic Acid and Antisense Oligonucleotide Fragments

5 -CGCTGCBBTC TGCTCCGGGG CTGCBGCBBC CTCBTCBGCTC TTGCCTGGBGTG GCTCBGCCTGG GCCTGCBGGG CCBCCBGGBGB BTGGCBGCBBG GBTGGCGBGGG TCCTCBTGGC TGGGGTCBCCT GGBGGBGGGB GBGCBGGGGG TCCTCBTGGC TGGGGTCCCT CTCTCCCGTC CT CCTACCTTGC TATAGAAGAC CTGGGACAGA GGACTGCTGT CTGCCCTCTC TGGTCACCCT GCCTAGCTAG AGGATCTGTG ACCCCAGCCA TGAGGACCCT CGCCATCCTT GCTGCCATTC TCCTGGTGGC CCTGCAGGCC CAGGCTGAGC CACTCCAGGC AAGAGCTGAT GAGGTTGCTG CAGCCCCGGA GCAGATTGCA GCGGACATCC CAGAAGTGGT TGTTTCCCTT GCATGGGACG AAAGCTTGGC TCCAAAGCAT CCAGGCTCAA GGAAAAACAT GGACTGCTAT TGCAGAATAC CAGCGTGCAT TGCAGGAGAA CGTCGCTATG GAACCTGCAT CTACCAGGGA AGACTCTGGG CATTCTGCTG CTGAGCTTGC AGAAAAAGAA AAATGAGCTC AAAATTTGCT TTGAGAGCTA CAGGGAATTG CTATTACTCC TGTACCTTCT GCTCAATTTC CTTT-3' (FRAG. NO:1804) (SEQ. ID NO:1815)

5'-CCTACCTTGC TATAGAAGAC CTGGGACAGA GGACTGCTGT CTGCCCTCTC TGGTCACCCT GCCTAGCTAG AGGATCTGTG ACCCCAGCCA TGAGGACCCT CGCCATCCTT GCTGCCATTC TCCTGGTGGC CCTGCAGGCC CAGGCTGAGC CACTCCAGGC AAGAGCTGAT GAGGTTGCTG CAGCCCCGGA GCAGATTGCA GCGGACATCC CAGAAGTGGT TGTTTCCCTT GCATGGGACG AAAGCTTGGC TCCAAAGCAT CCAGGCTCAA GGAAAAACAT GGACTGCTAT TGCAGAATAC CAGCGTGCAT TGCAGGAGAA CGTCGCTATG GAACCTGCAT CTACCAGGGA AGACTCTGGG CATTCTGCTG CTGAGCTTGC AGAAAAAGAA AAATGAGCTC

AAAATTTGCT TTGAGAGCTA CAGGGAATTG CTATTACTCC TGTACCTTCT GCTCAATTTC CTTT-3' (FRAG. NO: ) (SEQ.

ID NO:2478)

5' GAATTCCCTG TAAGCCCTGT TACAGGGGCT GCACCCCAGA TACAACCTGA CCTGTGTCCA AGGCGGGCAA CTCAACCCTT AGATATTGAA TGGGTCCCAT GGCACCAATG CTTAAACACC AGCAGCCCTC ACAACCACAG ATCGTGTTTT AAGGATGAGG AGGTAGTTCT CTGGATGCAC AGGCTTCAAT CCAAATGGGC TCATGACGCC GCAGCACACA CCCAGTCTGC AGCCTGAAGA GTTGGAGCAT TGCATTCACA GAAAGCATCC AGACATGATC ATGGGCTCAG GGATACACCT GTTCTCCGAT GTGTACCAGT GAAGGATGGA AACTCCTATG CCTCCCAGAA AGCACCACTC AAGCTTTTGC TGAATGCTTC TCTGAAGGCC CACAAGGCTG AGAGGCTGTG CAACACCAGC AGTAAAGTGA ATGCCCAGAC TCCCACCTCC TTTCTTGGGT GGCCATCTGG AAAGGCCACT CCCACCCTGA TGGCTAATGC CTCAGACCAG TTCTTGGCCC AGATGATCCT AGACAATTGT TTAAGCTTAA ACTGTTCATT GGCCAAGCAA ACAGGTGATA GTACCTCTGG GGAACCACAT GCCGCGTGTA CATCCAGATC TCAGGAGAAC CCAAAAATGT CTGTTCCACA TAGCAACAGA AGCCCAGGTA GCACTCAGTC TCACCTGGGT GTTCTCCAAC ATCCCAGCTC AGCCAAATGG CTTTCATTAG TTTTTATGGT TAGACCCCAG GTCCTCGGGA CACTGCTTTA GAAACACATT CCAAATCCTC CTCTGTGTGC AGGTGGCATT CCTATCCCAA TCTCTTTGCA GGGCGTATAC TGTGATACGC AGCCAGGCTG TCCCAGAGGC CTTAAATATT CCCTTGGTGC AGGTAGTTCA GCTTAGCCAC AGCCAATGCA TCACAGGGTC AACTGTGTTA GGAGCCATTG AGAATCCATA GTTGGTTGCT GCCTGGGCCT GGCCAGGGCT GACCAAGGTA GATGAGAGGT TCCTCTGTGG AGTTCTACTT TAACCTCACC TTCCCACCAA ATTTCTCAAC TGTCCTTGCC ACCACAATTA TTTAATGGAC CCAACAGAAA GTAACCCCGG AAATTAGGAC ACCTCATCCC AAAAGACCTT TAAATAGGGG AAGTCCACTT GTGCACGGCT GCTCCTTGCT ATAGAAGACC TGGGACAGAG GACTGCTGTC TGCCCTCTCT GGTCACCCTG CCTAGCTAGA GGATCTGTAA GTACTACAAA ACTTAAACTT TACACTGAGT TTTCATCATT GAAGCTATGC CTCCAATCTG ACCTCTGACT GTGGGGCCGC CCCAGAGGGA CCCAGCGGGT GAATCCCTGC TAGGAACGTC TGTCCGGACC TCTGGTGACT GCTGGGGACG ATGGCTTCCA GCTAACTTAA TAGAGAAACT CAAGCAGTTT CCTTCTAAAT ACACATGTCA CATGTCCTGG TTGACATGTC CAGTAAGAAG ACTATCACAG GTCTTTGGAA CATTCTTTTG AGAGAAACCT ATTTAGGTCC TTGGTCTGTT TTTCAATCAG GTTGTTTGAT TTTTGCTATT GAGTTGTTGG AATTCCTTAT GTATTCAGAT ATTTGCCCCT TCTGCCATGT AGGTTTTGCA AATATTTTCT CTCATTTTCT GGGTTATCTT TTCACTCGGT TGATTGTTTC CTTTGCTGTG CAGATGCTTT AGCGTTAAAT GAAGCCACAC TTGTCTATTT TCCCTTTTAT TGCCTGTGCC TTTGGTGTCA TAGCCAAGAA ATCATTACCT ACATCAATGT CAAAAGCTTT ATCCTTCTAT ACACTTCTAG TAGTTTATGG TTTCAGTTGT TACATTTAGG TTTTCAATTC ATTCTGAGTT GATGTTCCTA CATGGTGTGA GATAAAGATT TAAATACATA CATATATAAA ATCATGAGGT AGTGTACACT ATAAATATAC AATTGTTAAT TGTTACTCAA GTCTAAGTAG AGGTGGAAAT AATAAACTTT CTTTTTTTTA CTTAAACCAC TCTGTGTCAC TGAGCTGATT TCACCTTTAG CCTGATAAAA TCATTGTCCT CTCCACCCTG ATTCCTACAG GAGACTACTC ACCCCATAAC CTCAAAAACC TCTTCATGAG GATGGTAAGT CACCTGAATC CTGAAGTGAA TTACTCGCTA TTCCATTGGA ACTCATATAG GACACCAGAA TCTAGACCTC CAGAGAACAG CAGGACCCAT EPI-109 184

CTTCAGAAAA TAAGAAGCAT TTGTTCCCTG AGCCTGTTGA ATCAAAGTGC AATTTCTATT CTTTTTGGAA TGTTAAAAAG TGAATCATAA TATTTAAGCA GGTGAACCCA CGAGTAACAT AGCAGGGTCT TTCTTGTCAT TATTAGCTCC AACCTAGCAC AGACATTAAA GGTACAGATG TATACTAGCA TGAAACTGGG AGAACAGGAG CATTCGAGCA ACCTTGAGAC CAATGGGCCT CTCTTATAAA ATGCACACCT CCTCTCACTG AGATTGAGGA AGGTTTCTTG TCTCCGAGCC TTCTCCCAGT AGAGCTATAA ATCCAGGCTG GCTCCTCCCT CCCCACACAG CTGCTCCTGC TCTCCCTCCT CCAGGTGACC CCAGCCATGA GGACCCTCGC CATCCTTGCT GCCATTCTCC TGGTGGCCCT GCAGGCCCAG GCTGAGCCAC TCCAGGCAAG AGCTGATGAG GTTGCTGCAG CCCCGGAGCA GATTGCAGCG GACATCCCAG AAGTGGTTGT TTCCCTTGCA TGGGACGAAA GCTTGGCTCC AAAGCATCCA GGTGAGAGAG GCAGGCATGC AGAGCTGCTA AGTCTAGAGG GAAGGACGGG AGAGAGGTTC CAGAGTTGGG TCTCAGCAGT CTATGTCACT GAGGTGGCTT CACTTAGAAT CTCTGGGCAT TGATTTTCTC ATCTAGAAAT TGAACAGAGA GCCAAATAAA CCTGAGAAAC TTTATTTCTC CAAAGACTTG ATTCCAAGAA ACATCTGTGA AATTCACTAA GTTTAAGATA TGAAGAGACA GACTAGTTAT TTCTGGATCT AAACAAGTAG ACTTAGTTGT AAAGAGAACA TTTTACTCTA TCTACAGAAG AGCTTTTAAA AACTGCAGCC AAGCCTGAGG GTAAGTTCAG GTGTGTGTGT GATGGGGCAG GAATGCAAAA ATGAGAGCAA AGGAGAATGA GTCTCAAATT CTGTGTGACA AGCACTGCTC TGCGTGTTTA TTCCTATCGA CTGAGGTTGT TCGTGCTACC GGCTGCAATG CAGCCAGCAT CACCTGTCAG CTAGCATGTG ACTTCCCCGA GATTCTTTTT CTTACCCACT GCTAACTCCA TACTCAATTT CTCATGCTCT CCCTGTCCCA GGCTCAAGGA AAAACATGGA CTGCTATTGC AGAATACCAG CGTGCATTGC AGGAGAACGT CGCTATGGAA CCTGCATCTA CCAGGGAAGA CTCTGGGCAT TCTGCTGCTG AGCTTGCAGA AAAAGAAAAA TGAGCTCAAA ATTTGCTTTG AGAGCTACAG GGAATTGCTA TTACTCCTGT ACCTTCTGCT CAATTTCCTT TCCTCATCTC AAATAAATGC CTTGTTACAA GATTTCTGTG TTTCCACCTC TTTAATGTGT GATATGTGTC TGTGTCAAGA CACTTGGGAT ACACGTACCA

AAACGCAAAA TCAAATTTTT GAACAATATA-3' (FRAG. NO: ) (SEQ. ID NO:2477)

5 -GGCBGCBBGG-3' (FRAG. NO:1805) (SEQ. ID NO:1816)

5'-GG CTG GGG-3' (FRAG. NO:1806) (SEQ. ID NO:1817)

5'-GGGGTCBCC-3' (FRAG. NO:1807) (SEQ. ID NO:1818)

5'-GGG TCC TCB TGG CTG GGG TC-3' (FRAG. NO:1216) (SEQ. ID NO:1226)

5'-CCT CTC TCC CGT CCT-3' (FRAG. NO:1217) (SEQ. ID NO:1227)

5'-CGCTGCBBTC TGCTCCGGGG CTGCBGCBBC CTCBTCBGCTC TTGCCTGGBGTG GCTCBGCCTGG GCCTGCBGGG

CCBCCBGGBGB BTGGCBGCBBG GBTGGCGBGGG TCCTCBTGGC TGGGGTCBCCT GGBGGBGGGB GBGCBGG-3' (FRAG.

NO:1808) (SEQ. ID NO:1819)

Human Macrophage Inflammatory Protein-1-alpha/RANTES

Receptor Nucleic Acid and Antisense Oligonucleotide Fragments

5'-GTCTTTGTTT CTGGGCTCGT GCCCCBTCCC GGCTTCTCTC TGGTTCCGTC CTCTGTGGTG TTTGGCCCTG CTTCCTTTTG

CCTGTTGAGG GGGCAGCAGT TGGGCCCCAA AGGCCCTCTC GTTCACCTTC TGGCACGGAGTT GCATCCCCATA

GTCAAACTCT GTGGTCGTGT CATAGTCCTC TGTGGTGTTT GGAGTTTCCA TCCCGGCTTC TCTCTGGTTC CAAGGGAGB

GGGGGCBGCB GTTGGGCCCC BBBGGCCCTC TCGTTCBCCT TCTGGCBCGG BGTTGCBTCC CCBTBGTCBB BCTCTGTGGT

CGTGTCBTBG TCCTCTGTGG TGTTTGGBGT TTCCBTCCCG GCTTCTCTCT GGTTCCBBGG GB-3' (FRAG. NO: 1809) (SEQ. ID

NO:1820)

5 -GGGCC CC-3' (FRAG. NO:1810) (SEQ. ID NO:1821)

5 -GGGGGCBGC-3' (FRAG. NO:1811) (SEQ. ID NO:1822)

5'-CCCGGCTTC-3' (FRAG. NO:1812) (SEQ. ID NO:1823)

5'-GTC TTT GTT TCT GGG CTC GTG CC-3' (FRAG. NO:1218) (SEQ. ID NO:1228)

5'-CCB TCC CGG CTT CTC TCT GGT TCC-3' (FRAG. NO:1219) (SEQ. ID NO:1229)

5'-GTC CTCTGT GGT GTT TGG-3' (FRAG. NO:1220) (SEQ. ID NO:1230)

5'-CCC TGC TTC CTT TTG CCT GTT-3' (FRAG. NO:1221) (SEQ. ID NO:1231)

5'-GAGGGGGCAG CAGTTGGGCC CCAAAGGCCC TCTCGTTCAC CTTCTGGCAC GGAGTTGCAT CCCCATAGTC AAACTCTGTG

GTCGT-3' (FRAG. NO:1222) (SEQ. ID NO:1232)

₅'-GTCATAGTCCTCTGTGGTGTTΓGGAGTTTCCATCCCGGCTTCTCTCTGGTTCCAAGGGA-3'(FRAG. NO:1223)(SEQ.ID

NO:1233)

5'-GBGGGGGCBG CBGTTGGGCC CCBBBGGCCC TCTCGTTCBC CTTCTGGCBC GGBGTTGCBT CCCCBTBGTC BBBCTCTGTG

GTCGTG-3' (FRAG. NO:1224) (SEQ. ID NO:1234)

5'-TCBTBGTCCTCTGTGGTGTTTGGBGTTTCCBTCCCGGCTTCTCTCTGGTTCCBBGGGB-3' (FRAG. NO:1225) (SEQ. ID NO:1235)

RAN'IES Antisense Oligonucleotide Fragments

5'-GGGCBCGGGG CBGTGGGCGG GCBBTGTBGG CBBBGCBGCB GGGTGTGGTG TCCGBGGBBT BTGGGGBGGC BGBTGCBGGB

GCGCBGBGGG CBGTBGCBBT GBGGBTGBCB GCGBGGCGTG CCGCGGBGBC CTTCBTGGTB CCTGTGGBGB GGCTGTCGGB

GGGGGTGTGG TGTCCGCTTG GCGGTTCTTT CGGGTGTTTC TTCTCTGGGT TGGCCTGCTG CTCGTCGTGGT CGCTCCGCTC

CCGGGTTCGT CTCGCTCTGT CGCCCCTTCC TTCCTTGTCG TGTTCCTCCC TTCCTTGCCT CT-3' (FRAG. NO: 1813) (SEQ. ID

NO: 1824)

5 -GGGTTGGC-3' (FRAG. NO: 1814) (SEQ. ED NO: 1825)

5'-CGGGG CBG-3' (FRAG. NO: 1815) (SEQ. ID NO: 1826)

5'-CCCGGGTTCG-3' (FRAG. NO: 1816) (SEQ. ID NO: 1827)

5 -GGGTGTGGTG-3' (FRAG. NO: 1817) (SEQ. ID NO: 1828)

5'-GGGCBCGGGG CBGTGGGCGG GCBBTGTBGG CBBBGCBGCB GGGTGTGGTG TCCGBGGBBT BTGGGGBGGC BGBTGCBGGB

GCGC-3' (FRAG. NO:1226) (SEQ. ID NO:1236)

5'-BGBGGGCBGTBGCBBTGBGGBTGBCBGCGBGGCGTGCCGCGGBGBCCTTCBTGGTBCCTGTGGBGBGGCTGTCGGBGG-3'

(FRAG. NO:1227) (SEQ. ED NO:1237)

5'-GGGTGTGGTGTCCGCTTGGCGGTTCTTTCGGGTGTTTCTTCTCTGGGTTGGCCTGCTGCTCGTCGTGGTC-3 ' (FRAG. NO:1228)

(SEQ. ID NO:1238) 5'-GCTCCGCTCCCGGGTTCGTCTCGCTCTGTCGCCCCTTCCTTCCTTGTCGTGTTCCTCCCTTCCTTGCCTCT-3' (FRAG. NO:1229)

(SEQ. ED NO:1239) 5'-GGGTGTGGTGTCCG-3' (FRAG. NO:1230) (SEQ. ID NO:1240) EPI-109 185

5'-CTTGGCGGTTCTTTCGGGTG-3' (FRAG. NO:1231) (SEQ. ID NO:1241)

5'-TTTCTTCTCTGGGTTGGC-3' (FRAG. NO:1232) (SEQ. ED NO:1242)

5'-CTGCTGCTCGTCGTGGTC-3' (FRAG. NO:1233) (SEQ. ID NO:1243)

5'-GCTCCGCTCCCGGGTTC-3' (FRAG. NO:1234) (SEQ. ID NO:1244)

5'-GTCTCGCTCTGTCGCCC-3' (FRAG. NO:1235) (SEQ. ID NO:1245)

5'-CTTCCTTCCTTGTC-3' (FRAG. NO:1236) (SEQ. ID NO:1246)

5'-GTGTTCCTCCCTTCCTTGCCTCT-3' (FRAG. NO:1237) (SEQ. ED NO:1247)

5'-GGGCBCGGGG CBGTGGGCGG GCBBTGTBGG CBBBGCBGCB GGGTGTGGTG TCCGBGGBBT BTGGGGBGGC BGBTGCBGGB

GCGCBGBGGG CBGTBGCBBT GBGGBTGBCB GCGBGGCGTG CCGCGGBGBC CTTCBTGGTB CCTGTGGBGB GGCTGTCGGB

GG-3' (FRAG. NO:1818) (SEQ. ID NO:1829)

Human Muscarinic Acetylcholine Receptor HM1* Nucleic Acid and Antisense Oligonucleotide Fragments

5'-GCTGCCCGGC GGGGTGTGCG CTTCGCGCTC CCGTGCTCGG TTCTCTGTCT CCCGGTCCCC CTTGCCTGGC GTCTCGGGCC

TTCGTCCTCT TCCTCTTCTT CCTTCCGCTC CGTGGGGGCT GCTTGGTGGG GGCCTGTGCCT CGGGGTCCCG GGGCTTCTGG

CCCTTGCCGT TCATGGTGGC TAGGTGGGGC GTTCBTGGTG GCTBGGTGGG GC-3' (FRAG. NO:1819) (SEQ. ID NO: 1830)

5 -GGTGGGGC-3' (FRAG. NO:1820) (SEQ. ID NO: 1831)

5 -GCCCGGCGGGG-3' (FRAG. NO:1821) (SEQ. ID NO: 1832)

5'-CGG GGC TTC TGG CCC-3' (FRAG. NO:1822) (SEQ. ED NO: 1833)

5'-GTT CBT GGT GGC TBG GTG GGG C-3' (FRAG. NO:1238) (SEQ. ID NO:1248)

5' GCT GCC CGG CGG GGT GTG CGC TTG GC-3' (FRAG. NO:1239) (SEQ. ID NO:1249)

5'-GCT CCC GTG CTC GGT TCT CTG TCT CCC GGT-3' (FRAG. NO:1240) (SEQ. ED NO:1250)

5'-CCC CCT TTG CCT GGC GTC TCG G-3' (FRAG. NO:1241) (SEQ. ED NO:1251)

5'-GCC TTC GTC CTC TTC CTC TTC TTC CTT CC-3' (FRAG. NO:1242) (SEQ. ID NO:1252)

5' GCT CCG TGG GGG CTG CTT GGT GGG GGC CTG TGC CTC GGG GTC C-3' (FRAG. NO:1243) (SEQ. ID NO:1253)

5'-CGG GGC TTC TGG CCC TTG CC-3' (FRAG. NO:1244) (SEQ. ID NO:1254)

5'-GTT CAT GGT GGC TAG GTG GGG C-3' (FRAG. NO: 1245) (SEQ. ID NO:1255)

Human Muscarinic Acetylcholine Receptor HM3* Nucleic Acid and Antisense Oligonucleotide Fragments

5'-GGG GTG GGT BGG CCG TGT CTG GGGGTT GGC CBT GTT GGT TGC CTCT TGG TGG TGC GCC GGG CGCG TCT TGG CTT

TCT TCT CCT TCG GGC CCT CGG GCC GGT GCT TGT GGGCT CCT CCC GGG CGG CCT CCC CGG GCG GGG GCT TCT

TGGCG CTG GCG GGG GGG CCT CCTGCT CTG TGG CTG GGC GTT CCT TGG TGT TCT GGG TGGTGG CGG GCG TGG TGG

CCT CTG TGGGGG CCC GCG GCT GCB GGG GTTG CCT GTC TGC TTC GTCCTT TGC GCT CCC GGG CCG CCGGG GTG GGT

AGG CCG TGT CTG GGGGTT GGC CAT GTT GGT TGC CGGG CCC GCG GCT GCA GGG G-3' (FRAG. NO:1823) (SEQ. ID

NO: 1934)

5 -CCC GGG CGG-3' (FRAG. NO:1824) (SEQ. ID NO:1835)

5 -G GCG GGG GGG CC-3' (FRAG. NO:1825) (SEQ. ID NO:1836)

5' -CCC GGG CCG CC-3' (FRAG. NO: 1826) (SEQ. ID NO: 1837)

5 -GG CCG TGT-3' (FRAG. NO:1827) (SEQ. ID NO:1838)

5'-GGG GTG GGT BGG CCG TGT CTG GGG-3' (FRAG. NO:1246) (SEQ. ID NO:1256)

5'-GTT GGC CBT GTT GGT TGC C-3' (FRAG. NO:1247) (SEQ. ID NO:1257)

5'-TCT TGG TGG TGC GCC GGG C-3' (FRAG. NO:1248) (SEQ. ID NO:1258)

5'-GCG TCT TGG CTT TCT TCT CCT TCG GGC CCT CGG GCC GGT GCT TGT GG-3' (FRAG. NO:1249) (SEQ. ID NO:1259)

5'-GCT CCT CCC GGG CGG CCT CCC CGG GCG GGG GCT TCT TG-3' (FRAG. NO:1250) (SEQ. ID NO:1260)

5'-GCG CTG GCG GGG GGG CCT CCT CC-3' (FRAG. NO:1251) (SEQ. ID NO:1261)

5'-GCT CTG TGG CTG GGC GTT CCT TGG TGT TCT GGG TGG C-3' (FRAG. NO:1252) (SEQ. ID NO:1262)

5'-TGG CGG GCG TGG TGG CCT CTG TGG TGG-3' (FRAG. NO:1253) (SEQ. ID NO:1263)

5'-GGG CCC GCG GCT GCB GGG G-3' (FRAG. NO:1254) (SEQ. ID NO:1264)

5'-TTG CCT GTC TGC TTC GTC-3' (FRAG. NO:1255) (SEQ. ID NO:1265)

5'-CTT TGC GCT CCC GGG CCG CC-3' (FRAG. NO:1256) (SEQ. ID NO:1266)

5'-GGG GTG GGT AGG CCG TGT CTG GGG-3' (FRAG. NO:1257) (SEQ. ID NO:1267)

5'-GTT GGC CAT GTT GGT TGC C-3' (FRAG. NO:1258) (SEQ. ED NO:1268)

5 -GGG CCC GCG GCT GCA GGG G-3' (FRAG. NO:1259) (SEQ. ID NO:1269)

Human Fibronectin* Antisense Oligonucleotide Fragments

5'-CGG TTT CCT TTG CGG TC TTG GCC CGG GCT CCG GGT G CCC GCC CGC CCG CCG GCC GCC GC CCC GCC GGG CTG

TCC CCG CCC CGC CCC GGC CCG GGG CGC GGG GG CGG CCC TCC CGC CCC TCT GG GCC GGC GCG GGC GTC GG CCG

CTC GCG CCT GGG GTT CCC TCT CCT CCC CCT GTG C GCC TGC CTC TTG CTC TTCTGC GTC CGC TGC CTT CTC CC CTC

TCC TCG GCC GTT GCC TGT GC TGT CCG TCC TGT CGC CCT TCC GTG GTG C TGT TGT CTC TTC TGC CCT C GGT GTG

CTG GTG CTG GTG GTG GTG CCT CTG CCC GTG CTC GCCCTG CCT GGG CTG GCC TCT TCG GGT GTG GCT TTG GGG CTC

TCT TGG TTG CCC TTT CTT CTC GTG GTG CCT CTC CTC CCT GGC TTG GTC GT TGT CTG GGG TGG TGC TCC TCT CCC

TTT CCC TGC TGG CCG TTT GT

CCT GTT TTC TGT CTT CCT CT TTC CTC CTG TTT CTC CGT TTG GCT TGC TGC TTG CGG GGC TGT CTC C CTT GCC CCT

GTG GGC TTT CCC TGG TCC GGT CTT CTC CTT GGG GGT C GCC CTT CTT GGT GGG CTGGCT CGT CTG TCT TTT TCC TTC

C TGG GGG TGG CCG TTG TGG GCG GTG TGG TCC GCC T TGC CTC TGC TGG TCT TTC-3' (FRAG. NO:1828) (SEQ. ID NO:

1839)

S'-GGCCCGGGC-3' (FRAG. NO:1829) (SEQ. ID NO: 1840)

5'-GCCGGCGCGGGCG-3' (FRAG. NO:1830) (SEQ. ID NO:1841)

5'-GCCTGGGCTGGCC-3' (FRAG. NO:1831) (SEQ. ED NO: 1842)

5'-GGGGG TGGCCG-3' (FRAG. NO:1832) (SEQ. ID NO: 1843)

5'-GG GGG TGG CCG TTG TGG GCG G-3' (FRAG. NO:1833) (SEQ. ID NO: 1844)

5'-CGG TTT CCT TTG CGG TC-3' (FRAG. NO:1260)(SEQ. ED NO:1270) EPI-109 186

5'-TTG GCC CGG GCT CCG GGT G-3' (FRAG. NO:1261)(SEQ. ED NO:1271)

5'-CCC GCC CGC CCG CCG GCC GCC GC-3' (FRAG. NO:1262)(SEQ. ED NO:1272)

5'-CCC GCC GGG CTG TCC CCG CCC CGC CCC-3' (FRAG. NO:1263)(SEQ. ID NO:1273)

5'-GGC CCG GGG CGC GGG GG-3' (FRAG. NO:1264)(SEQ. ED NO:1274)

5'-CGG CCC TCC CGC CCC TCT GG-3' (FRAG. NO:1265)(SEQ. ID NO:1275)

5'-GCC GGC GCG GGC GTC GG-3' (FRAG. NO:1266)(SEQ. ED NO:1276)

5'-CCG CTC GCG CCT GGG GTT CCC TCT CCT CCC CCT GTG C-3' (FRAG. NO:1267)(SEQ. ED NO:1277)

5'-GCC TGC CTC TTG CTC TTC-3' (FRAG. NO:1268)(SEQ. ID NO:1278)

5'-TGC GTC CGC TGC CTT CTC CC-3' (FRAG. NO:1269)(SEQ. ID NO:1279)

5'CTC TCC TCG GCC GTT GCC TGT GC-3' (FRAG. NO:1270)(SEQ. ID NO:1280)

5'-TGT CCG TCC TGT CGC CCT TCC GTG GTG C-3' (FRAG. NO:1271)(SEQ. ED NO:1281)

5'-TGT TGT CTC TTC TGC CCT C-3' (FRAG. NO:1272)(SEQ. ID NO:1282)

5'-GGT GTG CTG GTG CTG GTG GTG GTG-3' (FRAG. NO:1273)(SEQ. ID NO:1283)

5'-CCT CTG CCC GTG CTC GCC-3' (FRAG. NO:1274)(SEQ. ED NO:1284)

5'-CTG CCT GGG CTG GCC TCT TCG GGT-3' (FRAG. NO:1275)(SEQ. ID NO:1285)

5'-GTG GCT TTG GGG CTC TCT TGG TTG CCC TTT-3' (FRAG. NO:1276)(SEQ. ID NO:1286)

5'-CTT CTC GTG GTG CCT CTC CTC CCT GGC TTG GTC GT-3' (FRAG. NO:1277)(SEQ. ID NO:1287)

5'- TGT CTG GGG TGG TGC TCC TCT CCC-3' (FRAG. NO:1278)(SEQ. ID NO:1288)

5'TTT CCC TGC TGG CCG TTT GT-3' (FRAG. NO:1279)(SEQ. ID NO:1289)

5' CCT GTT TTC TGT CTT CCT CT-3' (FRAG. NO:1280)(SEQ. ID NO:1290)

5'TTC CTC CTG TTT CTC CGT-3' (FRAG. NO:1281)(SEQ. ID NO:1291)

5'-TTG GCT TGC TGC TTG CGG GGC TGT CTC C-3' (FRAG. NO:1282)(SEQ. ED NO:1292)

5'-CTT GCC CCT GTG GGC TTT CCC-3' (FRAG. NO:1283)(SEQ. ID NO:1293)

5'-TGG TCC GGT CTT CTC CTT GGG GGT C-3' (FRAG. NO:1284)(SEQ. ID NO:1294)

5'-GCC CTT CTT GGT GGG CTG-3' (FRAG. NO:1285)(SEQ. ID NO:1295)

5'-GCT CGT CTG TCT TTT TCC TTC C-3' (FRAG. NO:1286)(SEQ. ID NO:1296)

5'-TGG GGG TGG CCG TTG TGG GCG GTG TGG TCC GCC T-3' (FRAG. NO:1287)(SEQ. ID NO:1297)

5'-TGC CTC TGC TGG TCT TTC-3' (FRAG. NO:1288)(SEQ. ID NO:1298)

Human Interleukin-1 (TL-1) Nucleic Acid and antisense Oligocnucleotide Fragments

₅'-AAGCTTCTAC CCTAGTCTGG TGCTACACTT ACATTGCTTA CATCCAAGTG TGGTTATTTC TGTGGCTCCT GTTATAACTA TTATAGCACC AGGTCTATGA CCAGGAGAAT TAGACTGGCA TTAAATCAGA ATAAGAGATT TTGCACCTGC AATAGACCTT ATGACACCTA ACCAACCCCA TTATTTACAA TTAAACAGGA ACAGAGGGAA TACTTTATCC AACTCACACA AGCTGTTTTC CTCCCAGATC CATGCTTTTT TGCGTTTATT ATTTTTTAGA GATGGGGGCT TCACTATGTT GCCCACACTG GACTAAAACT CTGGGCCTCA AGTGATTGTC CTGCCTCAGC CTCCTGAATA GCTGGGACTA CAGGGGCATG CCATCACACC TAGTTCATTT CCTCTATTTA AAATATACAT GGCTTAAACT CCAACTGGGA ACCCAAAACA TTCATTTGCT AAGAGTCTGG TGTTCTACCA CCTGAACTAG GCTGGCCACA GGAATTATAA AAGCTGAGAA ATTCTTTAAT AATAGTAACC AGGCAACATC ATTGAAGGCT CATATGTAAA AATCCATGCC TTCCTTTCTC CCAATCTCCA TTCCCAAACT TAGCCACTGG TTCTGGCTGA GGCCTTACGC ATACCTCCCG GGGCTTGCAC ACACCTTCTT CTACAGAAGA CACACCTTGG GCATATCCTA CAGAAGACCA GGCTTCTCTC TGGTCCTTGG TAGAGGGCTA CTTTACTGTA ACAGGGCCAG GGTGGAGAGT TCTCTCCTGA AGCTCCATCC CCTCTATAGG AAATGTGTTG ACAATATTCA GAAGAGTAAG AGGATCAAGA CTTCTTTCTG CTCAAATACC ACTGTTCTCT TCTCTACCCT GCCCTAACCA GGAGCTTGTC ACCCCAAACT CTGAGGTGAT TTATGCCTTA ATCAAGCAAA CTTCCCTCTT CAGAAAAGAT GGCTCATTTT CCCTCAAAAG TTGCCAGGAG CTGCCAAGTA TTCTGCCAAT TCACCCTGGA GCACAATCAA CAAATTCAGC CAGAACACAA CTACAGCTAC TATTAGAACT ATTATTATTA ATAAATTCCT CTCCAAATCT AGCCCCTTGA CTTCGGATTT CACGATTTCT CCCTTCCTCC TAGAAACTTG ATAAGTTTCC CGCGCTTCCC TTTTTCTAAG ACTACATGTT TGTCATCTTA TAAAGCAAAG GGGTGAATAA ATGAACCAAA TCAATAACTT CTGGAATATC TGCAAACAAC AATAATATCA GCTATGCCAT CTTTCACTAT TTTAGCCAGT ATCGAGTTGA ATGAACATAG AAAAATACAA AACTGAATTC TTCCCTGTAA ATTCCCCGTT TTGACGACGC ACTTGTAGCC ACGTAGCCAC GCCTACTTAA GACAATTACA AAAGGCGAAG AAGACTGACT CAGGCTTAAG CTGCCAGCCA GAGAGGGAGT CATTTCATTG GCGTTTGAGT CAGCAAAGGT ATTGTCCTCA CATCTCTGGC TATTAAAGTA TTTTCTGTTG TTGTTTTTCT CTTTGGCTGT TTTCTCTCAC ATTGCCTTCT CTAAAGCTAC AGTCTCTCCT TTCTTTTCTT GTCCCTCCCT GGTTTGGTAT GTGACCTAGA ATTACAGTCA GATTTCAGAA AATGATTCTC TCATTTTGCT GATAAGGACT GATTCGTTTT ACTGAGGGAC GGCAGAACTA GTTTCCTATG AGGGCATGGG TGAATACAAC TGAGGCTTCT CATGGGAGGG AATCTCTACT ATCCAAAATT ATTAGGAGAA AATTGAAAAT TTCCAACTCT GTCTCTCTCT TACCTCTGTG TAAGGCAAAT ACCTTATTCT TGTGGTGTTT TTGTAACCTC TTCAAACTTT CATTGATTGA ATGCCTGTTC TGGCAATACA TTAGGTTGGG CACATAAGGA ATACCAACAT AAATAAAACA TTCTAAAAGA AGTTTACGAT CTAATAAAGG AGACAGGTAC ATAGCAAACT AATTCAAAGG AGCTAGAAGA TGGAGAAAAT GCTGAATGTG GACTAAGTCA TTCAACAAAG TTTTCAGGAA GCACAAAGAG GAGGGGCTCC CCTCACAGAT ATCTGGATTA GAGGCTGGCT GAGCTGATGG TGGCTGGTGT TCTCTGTTGC AGAAGTCAAG ATGGCCAAAG TTCCAGACAT GTTTGAAGAC CTGAAGAACT GTTACAGGTA AGGAATAAGA TTTATCTCTT GTGATTTAAT GAGGGTTTCA AGGCTCACCA GAATCCAGCT AGGCATAACA GTGGCCAGCA TGGGGGCAGG CCGGCAGAGG TTGTAGAGAT GTGTACTAGT CCTGAAGTCA GAGCAGGTTC AGAGAAGACC CAGAAAAACT AAGCATTCAG CATGTTAAAC TGAGATTACA TTGGCAGGGA GACCGCCATT TTAGAAAAAT TATTTTTGAG GTCTGCTGAG CCCTACATGA ATATCAGCAT CAACTTAGAC ACAGCCTCTG TTGAGATCAC ATGCCCTGAT ATAAGAATGG GTTTTACTGG TCCATTCTCA GGAAAACTTG ATCTCATTCA GGAACAGGAA ATGGCTCCAC AGCAAGCTGG GCATGTGAAC TCACATATGC AGGCAAATCT CACTCAGATG TAGAAGAAAG GTAAATGAAC ACAAAGATAA AATTACGGAA CATATTAAAC TAACATGATG TTTCCATTAT CTGTAGTAAA TACTAACACA AACTAGGCTG TCAAAATTTT GCCTGGATAT TTTACTAAGT ATAAATTATG AAATCTGTTT TAGTGAATAC ATGAAAGTAA TGTGTAACAT ATAATCTATT TGGTTAAAAT AAAAAGGAAG TGCTTCAAAA CCTTTCTTTT CTCTAAAGGA GCTTAACATT CTTCCCTGAA CTTCAATTAA AGCTCTTCAA TTTGTTAGCC AAGTCCAATT TTTACAGATA AAGCACAGGT AAAGCTCAAA GCCTGTCTTG ATGACTACTA ATTCCAGATT AGTAAGATAT GAATTACTCT ACCTATGTGT ATGTGTAGAA GTCCTTAAAT TTCAAAGATG ACAGTAATGG CCATGTGTAT GTGTGTGACC CACAACTATC ATGGTCATTA AAGTACATTG GCCAGAGACC ACATGAAATA ACAACAATTA CATTCTCATC ATCTTATTTT GACAGTGAAA ATGAAGAAGA CAGTTCCTCC ATTGATCATC EPI-109 187

TGTCTCTGAA TCAGGTAAGC AAATGACTGT AATTCTCATG GGACTGCTAT TCTTACACAG TGGTTTCTTC ATCCAAAGAG AACAGCAATG ACTTGAATCT TAAATACTTT TGTTTTACCC TCACTAGAGA TCCAGAGACC TGTCTTTCAT TATAAGTGAG ACCAGCTGCC TCTCTAAACT AATAGTTGAT GTGCATTGGC TTCTCCCAGA ACAGAGCAGA ACTATCCCAA ATCCCTGAGA ACTGGAGTCT CCTGGGGCAG GCTTCATCAG GATGTTAGTT ATGCCATCCT GAGAAAGCCC CGCAGGCCGC TTCACCAGGT GTCTGTCTCC TAACGTGATG TGTTGTGGTT GTCTTCTCTG ACACCAGCAT CAGAGGTTAG AGAAAGTCTC CAAACATGAA GCTGAGAGAG AGGAAGCAAG CCAGCTGAAA GTGAGAAGTC TACAGCCACT CATCAATCTG TGTTATTGTG TTTGGAGACC ACAAATAGAC ACTATAAGTA CTGCCTAGTA TGTCTTCAGT ACTGGCTTTA AAAGCTGTCC CCAAAGGAGT ATTTCTAAAA TATTTTGAGC ATTGTTAAGC AGATTTTTAA CCTCCTGAGA GGGAACTAAT TGGAAAGCTA CCACTCACTA CAATCATTGT TAACCTATTT AGTTACAACA TCTCATTTTT GAGCATGCAA ATAAATGAAA AAGTCTTCCT AAAAAAATCA TCTTTTTATC CTGGAAGGAG GAAGGAAGGT GAGACAAAAG GGAGAGAGGG AGGGAAGCCT AATGAAACAC CAGTTACCTA AGACCAGAAT GGAGATCCTC CTCACTACCT CTGTTGAATA CAGCACCTAC TGAAAGAACT TTCATTCCCT GACCATGAAC AGCCTCTCAG CTTCTGTTTT CCTTCCTCAC AGAAATCCTT CTATCATGTA AGCTATGGCC CACTCCATGA AGGCTGCATG GATCAATCTG TGTCTCTGAG TATCTCTGAA ACCTCTAAAA CATCCAAGCT TACCTTCAAG GAGAGCATGG TGGTAGTAGC AACCAACGGG AAGGTTCTGA AGAAGAGACG GTTGAGTTTA AGCCAATCCA TCACTGATGA TGACCTGGAG GCCATCGCCA ATGACTCAGA GGAAGGTAAG GGGTCAAGCA CAATAATATC TTTCTTTTAC AGTTTTAAGC AAGTAGGGAC AGTAGAATTT AGGGGAAAAT TAAACGTGGA GTCAGAATAA CAAGAAGACA ACCAAGCATT AGTCTGGTAA CTATACAGAG GAAAATTAAT TTTTATCCTT CTCCAGGAGG GAGAAATGAG CAGTGGCCTG AATCGAGAAT ACTTGCTCAC AGCCATTATT TCTTAGCCAT ATTGTAAAGG TCGTGTGACT TTTAGCCTTT CAGGAGAAAG CAGTAATAAG ACCACTTACG AGCTATGTTC CTCTCATACT AACTATGCCT CCTTGGTCAT GTTACATAAT CTTTTCGTGA TTCAGTTTCC TCTACTGTAA AATGGAGATA ATCAGAATCC CCCACTCATT GGATTGTTGT AAAGATTAAG AGTCTCAGGC TTTACAGACT GAGCTAGCTG GGCCCTCCTG ACTGTTATAA AGATTAAATG AGTCAACATC CCCTAACTTC TGGACTAGAA TAATGTCTGG TACAAAGTAA GCACCCAATA AATGTTAGCT ATTACTATCA TTATTATTAT TATTTTATTT TTTTΠTITG AGATGGAGTC TGGCTCTGTC ACCCAGGCTG GAGTGCAGTG GCACAATCTC GGCTCACTGC AAGCTCTGCC TCCTGGGTTC ATGCCATTCT CCTGCCTCAG CCTCCCGAGT AAGCTGGGAA TACAGGCACC CGCCACTGTT CCCGGCTAAT TTTTTGTATT TTTAGTAGAG ACGGAGTTTC ACCGTGGTCT CCATCTCCTC GTGATCCACC CACCTTGGCC TCCCAAAGTG CCGGGATTAC AGGCGTGAGC CACCGCGCCC GGCCTATTAT TATTATTATT ACTACTACTA CTACCTATAT GAATACTACC AGCAATACTA ATTTATTAAT GACTGGATTA TGTCTAAACC TCACAAGAAT CCTACCTTCT CATTTTACAT AAAAGGAAAC TAAGCTCATT GAGATAGGTA AACTGCCCAA TGGCATACAT CTGTAAGTGG GAGAGCCTCA AATCTAATTC AGTTCTACCT GAGTAAAAAA ATCATGGTTT CTCCTCCATC CCTTTACTGT ACAAGCCTCC ACATGAACTA TAAACCCAAT ATTCCTGTTT TTAAGATAAT ACCTAAGCAA TAACGCATGT TCACCTAGAA GGTTTTAAAA TGTAACAAAA TATAAGAAAA TAAAAATCAC TCATATCGTC AGTGAGAGTT TACTACTGCC AGCACTATGG TATGTTTCCT TAAAATCTTT GCTATACACA TACCTACATG TGAACAAATA TGTCTAACAT CAAGACCACA CTATTTACAA CTTTATATCC AGCTTTTCTT ACTTAGCAAT GTATTGAGGA CATTTTAGAG TGCCCGTTTT TCACCATTAT AAGCAATGCA ACAATGAACA TCTGTATAAA TAAATATTCA TTTCTCTCAC CCTTTATTTC CTTAGAATAT ATTCCTAGAA GTAGAATTTC CCAGAGCCAT GAGGATTTGT GACGCTATTG ATATGTGCCA CTTTGCACTC TCTGTGACAT ATATAATTAT TTTTAATGCA TTCATTTTTT TCTCAGAGTG CATTCGTTTG AAAACATAGA CGGGAAATAC TGGTAGTCTT CCTTGTCAGT TAGAAACACC CAAACAATGA AAAATGAAAA AGTTGCACAA ATAGTCTCTA AAAACAATGA AACTATTGCC TGAGGAATTG AAGTTTAAAA AGAAGCACAT AAGCAACAAC AAGGATAATC CTAGAAAACC AGTTCTGCTG ACTGGGTGAT TTCACTTCTC TTTGCTTCCT CATCTGGATT GGAATATTCC TAATACCCCC TCCAGAACTA TTTTCCCTGT TTGTACTAGA CTGTGTATAT CATCTGTGTT TGTACATAGA CATTAATCTG CACTTGTGAT CATGGTTTTA GAAATCATCA AGCCTAGGTC ATCACCTTTT AGCTTCCTGA GCAATGTGAA ATACAACTTT ATGAGGATCA TCAAATACGA ATTCATCCTG AATGACGCCC TCAATCAAAG TATAATTCGA GCCAATGATC AGTACCTCAC GGCTGCTGCA TTACATAATC TGGATGAAGC AGGTACATTA AAATGGCACC AGACATTTCT GTCATCCTCC CCTCCTTTCA TTTACTTATT TATTTATTTC AATCTTTCTG CTTGCAAAAA ACATACCTCT TCAGAGTTCT GGGTTGCACA ATTCTTCCAG AATAGCTTGA AGCACAGCAC CCCCATAAAA ATCCCAAGCC AGGGCAGAAG GTTCAACTAA ATCTGGAAGT TCCACAAGAG AGAAGTTTCC TATCTTTGAG AGTAAAGGGT TGTGCACAAA GCTAGCTGAT GTACTACCTC TTTGGTTCTT TCAGACATTC TTACCCTCAA TTTTAAAACT GAGGAAACTG TCAGACATAT TAAATGATTT ACTCAGATTT ACCCAGAAGC CAATGAAGAA CAATCACTCT CCTTTAAAAA GTCTGTTGAT CAAACTCACA AGTAACACCA AACCAGGAAG ATCTTTATTA TCTCTGATAA CATATTTGTG AGGCAAAACC TCCAATAAGC TACAAATATG GCTTAAAGGA TGAAGTTTAG TGTCCAAAAA CTTTTATCAC ACACATCCAA TTTTCATGGC GGACATGTTT TAGTTTCAAC AGTATACATA TTTTCAAAGG TCCAGAGAGG CAATTTTGCA ATAAACAAGC AAGAClTTTT CTGATTGGAT GCACTTCAGC TAACATGCTT TCAACTCTAC ATTTACAAAT TATTTTGTGT TCTATTTTTC TACTTAATAT TATTTCTGCA ATTTTCCCAA TATTGACATC GTGTATGTAT TTGCCATTTT TAATATCACT AGACAATTCA ATCAGGTTGC TACGTTGGTC CCTTGGGTTT ACTCTAAATA GCTTGATTGC AAATATCTTT GTATATATTA TTGTTTTTTC TCCTATCTTG TAATTTCTTT GAGCACATCC CAAAGAGGAA TGCCTAGATC AATGGGCACA AATAATTTGA CAGCTCTTAT TAAACATTAT TCTGTAAGTA AAAACTGAAC TACTTTTCAG TATCACTAGC AACATATGAG TGTATCAGCT TCCTAAACCC CTCCATGTTA GGTCATTATG AACTTATGAT CTAACAAATT ACAGGGTCTT ATCCCACTAA TGAAATTATA AGAGATTCAA CACTTATTCA GCCCCGAAGG ATTCATTCAA CGTAGAAAAT TCTAAGAACA TTAACCAAGT ATTTACCTGC CTAGTGAGTG TGGAAGACAT TGTGAAGGAC ACAAAGATGT ATAGAATTCC ATTCCTGACT TCCAGGTATT TACACCATAG GTGGGGACCT AACTACACAC ACACACACAC ACACACACAC ACACACACAC ACCATGCACA CACAATCTAC ATCAACACTT GATTTTATAC AAATACAATG AATTTACTTT CTTTTTGGTT CTTCTCTTCA CCAGTGAAAT TTGACATGGG TGCTTATAAG TCATCAAAGG ATGATGCTAA AATTACCGTG ATTCTAAGAA TCTCAAAAAC TCAATTGTAT GTGACTGCCC AAGATGAAGA CCAACCAGTG CTGCTGAAGG TCAGTTGTCC TTTGTCTCCA ACTTACCTTC ATTTACATCT CATATGTTTG TAAATAAGCC CAATAGGCAG ACACCTCTAA CAAGGTGACA CTGTCCTCTT TCCTTCCTAC CACAGCCCCC ACCTACCCAC CCCACTCCCA TTGATTCCAG AGGCGTGCCT AGGCAGGATC TATGAGAAAA TATAACAGAG AGTAAGAGGA AAATTACCTT CTTTCTTTTT CCTTTCCCTG CCTGACCTTA TTCACCTCCC ATCCCAGAGC ATCCATTTAT TCCATTGATC TTTACTGACA TCTATTATCT GACCTACACA ATACTAGACA TTAGGACAAT GTGGCCTGCC TCCAAGAAAC TCAAATAAGC CAACTGAGAT CAGAGAGGAT TAATCACCTG CCAATGGGCA CAAAGCAACA AGCTGGGAGC CAAGTCCCAA AATGGGGCCT GCTGCTTCCA GTTCCCCTCT CTCTGCATTG ATGTCAGCAT TATCCTTCGT CCCAGTCCTG TCTCCACTAC CACTTTCCCC CTCAAACACA CACACACACA ACAGCCTTAG ATGTTTTCTC CACTGATAAG TAGGTGACTC AATTTGTAAG TATATAATCC AAGACCTTCT ATTCCCAAGT AGAATTTATG TGCCTGCCTG TGCTTTTCTA CCTGGATCAA GTGATGTCTA CAGAGTAGGG CAGTAGCTTC ATTCATGAAC TCATTCAACA AGCATTATTC ACTGAGAGCC TTGTATTTTT CAGGCATAGT GCCAACAGCA GTGTGGACAG EPI-109 188

TGGTGCATCA AAGCCTCTAG TCTCATAGAA CTTAGTCTTC TGGAGGATAT GGAAAACAGA CAACCCAAAC AACCAACAAA AGAGCAAGAT GCTGCAAAAA AAAAAAAAAT GAATAGGGTG CTAAGATAGA GAAAAGTGGG AGAGTGCTAT TTAGACAAAG TGGTAAAAAC AAAGCCCCTT GTGAGATGAG AGCTGCCGAC AGAGGGGGCG GGTCATGGTT GTGGGTTTTT GGGTAGGACA TTCAGAGGAG GGGGCGGGTC GTGGTTGTGG GTTTTTGGGT AGGACATTCA GAGGAGGGGG CGGGTCGTGG TTGTGGGTTT TTGGGTAGGA CATTCAGAGG AGGGGGCGGG TCGTGGTTGT GGGTTTTTGG GTAGGACATT CAGAGGAGGG GGCGGGTCGT GGTTGTGGGT TTTTGGGACA TTCAGAGGAG TCTGAATGCA CCCAGGCCTA CAACTTCAAG ATGGTAAAGG ACAGCTCCAA GGATCAGAAG AAGCATTCTT GGAACTGGGG CATTTTGAGA AGGAGGAAAA ATATGCAGAG ACTAGTGCTT GCAGAGCTTG CATTTGGATT TCATTTGAGG TACAATGAAA ACCCATTAAT GGGTTTCACA CAGTGCAATG GCCTGACCTC ACTTATATTT CCTAAAATAG AAAACAGATC AGAAGGAAGG CAATAGAGAA GCAGAAAGTC CAATGAGGAG GTTTCACAGC AGTCATGGGG GTGGGGTAAG GAAAAGAAGT GGAAAGAAAC AGACAGAATT GGGTTATATT TTGGAGATAG AACCAACAGA AGGAAGAGGA GAAACAACAT TTACTGAGAA GGGAAAAAGT AGGAGAGGAA TAGGTTTGGG AAATAAATCC TGCTGACATT GGAAACCCCA AGGAAGCCTC AAAAGTATAT TTACTTGCTT TAGATTTAAA AGAATAGGAA AGAAGCATCT CAACTTGGAA TTTGAAATCT ATTTTTCCAT AAAAGTATTG TTAAATTCTA CTCATACTCA CAAGAAAAGT ACATTCTAAA GAGTATATTG AAAGAGTTTA CTGATATACT TAGGAATTTT GTGTGTATGT GTGTGTGTGT ATGTGTGTGT GTGTGTTTAA CCTTCAATTG TTGACTTAAA TACTGAGATA AATGTCATCT AAATGCTAAA TTGATTTCCC AAAGGTATGA TTTGTTCACT TGGAGATCAA AATGTTTAGG GGGCTTAGAA TCACTGTAGT GCTCAGATTT GATGCAAAAT GTCTTAGGCC TATGTTGAAG GCAGGACAGA AACAATGTTT CCCTCCTACC TGCCTGGATA CAGTAAGATA CTAGTGTCAC TGACAATCTT CATAACTAAT TTAGATCTCT CTCCAATCAA CTAAGGAAAT CAACTCTTAT TAATAGACTG GGCCACACAT CTACTAGGCA TCTAATAAAT GCTTGCTGAA TGAACAAATG AATGAAGAGC CTATAGCATC ATGTTACAGC CATAGTCCTA AAGTGGTGTT TCTCATGAAG GCCAAATGCT AAGGGATTGA GCTTCAGTCC TTTTTCTAAC ATCTTGTTCT CTAACAGAAT TCTCTTCTTT TCTTCATAGG AGATGCCTGA GATACCCAAA ACCATCACAG GTAGTGAGAC CAACCTCCTC TTCTTCTGGG AAACTCACGG CACTAAGAAC TATTTCACAT CAGTTGCCCA TCCAAACTTG TTTATTGCCA CAAAGCAAGA CTACTGGGTG TGCTTGGCAG GGGGGCCACC CTCTATCACT GACTTTCAGA TACTGGAAAA CCAGGCGTAG GTCTGGAGTC TCACTTGTCT CACTTGTGCA GTGTTGACAG TTCATATGTA CCATGTACAT GAAGAAGCTA AATCCTTTAC TGTTAGTCAT TTGCTGAGCA TGTACTGAGC CTTGTAATTC TAAATGAATG TTTACACTCT TTGTAAGAGT GGAACCAACA CTAACATATA ATGTTGTTAT TTAAAGAACA CCCTATATTT TGCATAGTAC CAATCATTTT AATTATTATT CTTCATAACA ATTTIAGGAG GACCAGAGCT ACTGACTATG GCTACCAAAA AGACTCTACC CATATTACAG ATGGGCAAAT TAAGGCATAA GAAAACTAAG AAATATGCAC AATAGCAGTT GAAACAAGAA GCCACAGACC TAGGATTTCA TGATTTCATT TCAACTGTTT GCCTTCTGCT TTTAAGTTGC TGATGAACTC TTAATCAAVT ACCATAAGTT TCTGGGACCT CAGTTTTΛTC ATTTTCAAAA TGGAGGGAAT AATACCTAAG CCTTCCTGCC GCAACACTTT TTΓATGCTAA TCAGGGAGGT CATTTTGGTA AAATACTTCT CGAAGCCGAG CCTCAAGATG AAGGCAAAGC ACGAAATGTT ATTTTTTAAT TATTA ΠTAT ATATGTATTT ATAAATATAT TTAAGATAAT TATAATATAC TATATTTATG GGAACCCCTT CATfCTCTGA GTGTGACCAG GCATCCrCCA CAATAGCAGA CAGTGTTTTC TGGGATAAGT AAGTΓTGATT TCATTAATAC AGGGCATTTT GCTCCAAGTT GTGCTTΛTCC CATAGCCAGG AAACTCTGCA TTCTAGTACT TGGGAGACCT GTAATCATAT AATAAATGTA CATTAATTAC CTTGAGCCAG TAATTGGTCC GATCTTTGAC TCTTTTGCCA TTAAACTTAC CTGGGCATTC TTGTTTCATT CAATTCCACC TGCAATCAAG TCCTACAAGC TAAAATTAGA TGAACTCAAC TTTGACAACC ATGAGACCAC TGTTATCAAA ACTTTCTTTT CTGGAATGTA ATCAATGTTT CTTCTAGGTT CTAAAAATTG TGATCAGACC ATA VTGTTAC ATTATTATCA AC TAGTGA TTGATAGAGT GTTATCAGTC ATAACTAAAT AAAGCTTGCA ACAAAATTCT CTG CACATA GTTATTCATT

GCCTTAATCA TTATΠTACT GCATGGTAAT TAGGGACAAA TGGTAAATGT TTACATAAAT ^•.ATΓGTATTT AGTGTTACTT

TATAAAATCA AΛCCΛAGATT TTΛTATTTTT TTCTCCTCTT TGTTAGCTGC CAGTATGC:AT AAATCGCATT AAGAATGATA ATA ΓITCCGG GTTCACTTAA AGCTCATATT ACACATACAC AAAACATGTG TTCCCATCTT TATACAAACT ACACATACA GAGCTACATT AAAAACΛACT AA'IAGGCCAG CCACGGTGGC TCAGACCTGT AATCCCAGCA CITTGGGAGG ACCAACCTCT TCGAGGCACA AGGCACAACA GGCTGCTCTG GGATTCTCTT CAGCCAATCT TCATTGCTCA AGTGTCTGAA ΠCAGCCATGG

CAGAAGTACC TGAGCICGCC AGTGAAATGA TGGCTTATTA CAGTGGCAAT GAGGATGACT TGTTCΠTGA AGCTGATGGC CCΓAAACAGA TGAAGTGCTC CTTCCAGGAC CTGGACCTCT GCCCTCTGGA TGGCGGCATC CAGCTACGAA TCTCCGACCA CCACTACAGC AAGGGCTTCA GGCAGGCCGC GTCAGTTGTT GTGGCCATGG ACAAGCTGAG GA^GATGCTG GTTCCCTGCC CACAGACCTT CCAGGAGAAT GACCTGAGCA CCTTCTTTCC CTTCATCTTT GAAGAAGAAC CTATCTΪCTT CGACACATGG

GAΓAACGAGG CΓTATGTGCA CGATGCACCT GTACGATCAC TGAACTGCAC GCTCCGGGAC TCACAGCAAA AAAGCTTGGr GATGTCTGGT CCATATGAAC TGAAAGCTCT CCACCTCCAG GGACAGGATA TGGAGCAACA AGTGGTGTTC TCCATGTCCT TTGfACAAGG AGAAGAAAGT AATGACAAAA TACCTGTGGC CTTGGGCCTC AAGGAAAAGA ATCTGTACCT GTCCTGCGTG TTGAAAGATG ATAAGCCCAC TCTACAGCTG GAGAGTGTAG ATCCCAAAAA TTACCCAAAG AAGAAGATGG AAAAGCGATT TGTCΓTCAAC AAGATAGAAA TCAATAACAA GCTGGAATTT GAGTCTGCCC AGTTCCCCAA CTGCTACΛTC AGCACCTCTC

AAGCAGAA A CATGCXGTC TTCCTGGGAG GGACCAAAGG CGGCCAGGAT ATAACTGACT TCACCATGCA ATTTCITGTCT TCCTAAAGAG AGCTGTACCC ΛGAGAG^TCCT GTGCTGAATG TGGACTCAAT CCCTAGGGCT GGCAGAAAGG GAACAGAAAG GTTTTTGAGT ACGGCTATAG CCTGGACTTT CCTGTTGTCT ACACCAATGC CCAACTGCCT GCCTTAGGGT AGTGCTAAGA GGA ΓCΓCCTG TCCATCAGCC AGGACAGTCA GCTCTCTCCT TTCAGGGCCA ATCCCCAGCC CTTTTGTTGA G CΛGGCCTC TCTCACCTCT CCΓACTCACT TAAAGCCCGC CTGACAGAAA CCACGGCCAC ATTTGGTTCT AAGAAACCCT CTGTCATTCG

CTCCCACATT CTGATGAGCA ACCGCTTCCC TATITATTTA TTTATTTGTT TGTTTGTTrT ATTCATTGGT CTAATTTATT CAAAGGGGGC AAGAAGTAGC AGTGTCTGTA AAAGAGCCTA GTTTTTAATA GCTATGGAΛT CAATTCAATT TGGACTGGTG TGCTCTCTTT AAATCAAGTC CTTTAATΓAA GACTGAAΛAT ATATAAGCTC AGArrATTTA AΛTGGGAATA TTTΛTAAATG

AGCAAΛTATC ATACTGTTCA ATGGTTCTG AATAΛACTTC TCTGAAG AGAAAGAAAG AGAGΛGAGAA AGAAAAGAAA GAGGAAGGAA GGAAGGA GG AAGAAAGACA GGCTCTGAGG AAGGTGGCAG TL CCTACAAC GGGAGAACCA GTGGTΓAATT TGCAAAGTGG AΓCCTGTGGA GGCANNCAG GGAGTCCCCT AGGCCACCCA GACΆGGGCΓT TTAGCTATCT GCAGGCCAGA CΛΓCAAATTT CACGAGGGCT CAGI GTTAGG AATGGATTAT GGCTTATCAA ATTCACAGGA AACTΛACATG TTG XACAGCT TTTAGATTTC CTGTGGAAAA TATAACTTAC TAAAGATGGA GTTCTTGTGA CTGACTCCTG ATATCAAGAT

ACTGGGAGCC ΛAATTAAAAA TCΛGAAUGCT CCTTGGAGAG CAAGTCCATG AAATGCTCIT TTTCCCACAG TAGΛΛCCTAT

TTCCCTCGTG TCT A.V*TΛC ΓTGCACAGAG GCTCACTCCC TT GGATAATG CAGAGCGAGC ΛCGATΛCCTG GCACATACTA ATTTGAATAA AATGCTGTCA AAT CCCATT CACCCATΓCA Λ CAGCAAAC TCTATCT CAC CTGAATGTAC ATGCCAGGCA CTGTGCTAGA CΓTG?.C ΓCAA AAAGATITCA GTTTCCTGGA GGAACCAGGA GGGCAAGGTT CAACTCAGT GCTΛTAAGAA GI GTTAΓA&G CTGCACACGG TGGCTCACGC C ΓG ΓAATCCC AACA ΓTTGGG AGGCCGAGGC GGGC ^GATCA CAACGTCAGG EPI-109 189

AGATCGAGAC CATCCTGGCT AACATGGTGA AACCCTGTCT CTACTAAAAA TACAAAAAAT TAGCCGGGCG TTGGCGGCAG GTGCCTGTAG TCCCAGCTGC TGGGGAGGCT GAGGCAGGAG AATGGTGTGA ACCCGGGAGG CGGAACTTGC AGGGGGCCGA GATCGTGCCA CTGCACTCCA GCCTGGGCGA CAGAGTGAGA CTCTGTCTCA AAAAAAAAAA AAAAGTGTTA TGATGCAGAC CTGTCAAAGA GGCAAAGGAG GGTGTTCCTA CACTCCAGGC ACTGTTCATA ACCTGGACTC TCATTCATTC TACAAATGGA GGGCTCCCCT GGGCAGATCC CTGGAGCAGG CACTTTGCTG GTGTCTCGGT TAAAGAGAAA CTGATAACTC TTGGTATTAC CAAGAGATAG AGTCTCAGAT GGATATTCTT ACAGAAACAA TATTCCCACT TTTCAGAGTT CACCAAAAAA TCATTTTAGG CAGAGCTCAT CTGGCATTGA TCTGGTTCAT CCATGAGATT GGCTAGGGTA ACAGCACCTG GTCTTGCAGG GTTGTGTGAG CTTATCTCCA GGGTTGCCCC AACTCCGTCA GGAGCCTGAA CCCTGCATAC CGTATGTTCT CTGCCCCAGC CAAGAAAGGT CAATTTTCTC CTCAGAGGCT CCTGCAATTG ACAGAGAGCT CCCGAGGCAG AGAACAGCAC CCAAGGTAGA GACCCACACC CTCAATACAG ACAGGGAGGG CTATTGGCCC TTCATTGTAC CCATTTATCC ATCTGTAAGT GGGAAGATTC CTAAACTTAA GTACAAAGAA GTGAATGAAG AAAAGTATGT GCATGTATAA ATCTGTGTGT CTTCCACTTT GTCCCACATA TACTAAATTT AAACATTCTT CTAACGTGGG AAAATCCAGT ATTTTAATGT GGACATCAAC TGCACAACGA TTGTCAGGAA AACAATGCAT ATTTGCATGG TGATACATTT GCAAAATGTG TCATAGTTTG CTACTCCTTG CCCTTCCATG AACCAGAGAA TTATCTCAGT TTATTAGTCC CCTCCCCTAA GAAGCTTCCA CCAATACTCT TTTCCCCTTT CCTTTAACTT GATTGTGAAA TCAGGTATTC AACAGAGAAA TTTCTCAGCC TCCTACTTCT GCTTTTGAAA GCTATAAAAA CAGCGAGGGA GAAACTGGCA GATACCAAAC CTCTTCGAGG CACAAGGCAC AACAGGCTGC TCTGGGATTC TCTTCAGCCA ATCTTCATTG CTCAAGTATG ACTTTAATCT TCCTTACAAC TAGGTGCTAA GGGAGTCTCT CTGTCTCTCT GCCTCTTTGT GTGTATGCAT ATTCTCTCTC TCTCTCTCTT TCTTTCTCTG TCTCTCCTCT CCTTCCTCTC TGCCTCCTCT CTCAGCTTTT TGCAAAAATG CCAGGTGTAA TATAATGCTT ATGACTCGGG AAATATTCTG GGAATGGATA CTGCTTATCT AACAGCTGAC ACCCTAAAGG TTAGTGTCAA AGCCTCTGCT CCAGCTCTCC TAGCCAATAC ATTGCTAGTT GGGGTTTGGT TTAGCAAATG CTTTTCTCTA GACCCAAAGG ACTTCTCTTT CACACATTCA TTCATTTACT CAGAGATCAT TTCTTTGCAT GACTGCCATG CACTGGATGC TGAGAGAAAT CACACATGAA CGTAGCCGTC ATGGGGAAGT CACTCATTTT CTCCTTTTTA CACAGGTGTC TGAAGCAGCC ATGGCAGAAG TACCTGAGCT CGCCAGTGAA ATGATGGCTT ATTACAGGTC AGTGGAGACG CTGAGACCAG TAACATGAGC AGGTCTCCTC TTTCAAGAGT AGAGTGTTAT CTGTGCTTGG AGACCAGATT TTTCCCCTAA ATTGCCTCTT TCAGTGGCAA ACAGGGTGCC AAGTAAATCT GATTTAAAGA CTACTTTCCC ATTACAAGTC CCTCCAGCCT TGGGACCTGG AGGCTATCCA GATGTGTTGT TGCAAGGGCT TCCTGCAGAG GCAAATGGGG AGAAAAGATT CCAAGCCCAC AATACAAGGA ATCCCTTTGC AAAGTGTGGC TTGGAGGGAG AGGGAGAGCT CAGATTTTAG CTGACTCTGC TGGGCTAGAG GTTAGGCCTC AAGATCCAAC AGGGAGCACC AGGGTGCCCA CCTGCCAGGC CTAGAATCTG CCTTCTGGAC TGTTCTGCGC ATATCACTGT GAAACTTGCC AGGTGTTTCA GGCAGCTTTG AGAGGCAGGC TGTTTGCAGT TTCTTATGAA CAGTCAAGTC TTGTACACAG GGAAGGAAAA ATAAACCTGT TTAGAAGACA TAATTGAGAC ATGTCCCTGT TTTTATTACA GTGGCAATGA GGATGACTTG TTCTTTGAAG CTGATGGCCC TAAACAGATG AAGGTAAGAC TATGGGTTTA ACTCCCAACC CAAGGAAGGG CTCTAACACA GGGAAAGCTC AAAGAAGGGA GTTCTGGGCC ACTTTGATGC CATGGTATTT TGTTTTAGAA AGACTTTAAC CTCTTCCAGT GAGACACAGG CTGCACCACT TGCTGACCTG GCCACTTGGT CATCATATCA CCACAGTCAC TCACTAACGT TGGTGGTGGT GGCCACACTT GGTGGTGACA GGGGAGGAGT AGTGATAATG TTCCCATTTC ATAGTAGGAA GACAACCAAG TCTTCAACAT AAATTTGATT ATCCTTTTAA GAGATGGATT CAGCCTATGC CAATCACTTG AGTTAAACTC TGAAACCAAG AGATGATCTT GAGAACTAAC ATATGTCTAC CCCTTTTGAG TAGAATAGTT TTTTGCTACC TGGGGTGAAG CTTATAACAA CAAGACATAG ATGATATAAA CAAAAAGATG AATTGAGACT TGAAAGAAAA CCATTCACTT GCTGTTTGAC CTTGACAAGT CATTTTACCC GCTTTGGACC TCATCTGAAA AATAAAGGGC TGAGCTGGAT GATCTCTGAG ATTCCAGCAT CCTGCAACCT CCAGTTCTGA AATATTTTCA GTTGTAGCTA AGGGCATTTG GGCAGCAAAT GGTCATTTTT CAGACTCATC CTTACAAAGA GCCATGTTAT ATTCCTGCTG TCCCTTCTGT TTTATATGAT GCTCAGTAGC CTTCCTAGGT GCCCAGCCAT CAGCCTAGCT AGGTCAGTTG TGCAGGTTGG AGGCAGCCAC TTTTCTCTGG CTTTATTTTA TTCCAGTTTG TGATAGCCTC CCCTAGCCTC ATAATCCAGT CCTCAATCTT GTTAAAAACA TATTTCTTTA GAAGTTTTAA GACTGGCATA ACTTCTTGGC TGCAGCTGTG GGAGGAGCCC ATTGGCTTGT CTGCCTGGCC TTTGCCCCCC ATTGCCTCTT CCAGCAGCTT GGCTCTGCTC CAGGCAGGAA ATTCTCTCCT GCTCAACTTT CTTTTGTGCA CTTACAGGTC TCTTTAACTG TCTTTCAAGC CTTTGAACCA TTATCAGCCT TAAGGCAACC TCAGTGAAGC CTTAATACGG AGCTTCTCTG AATAAGAGGA AAGTGGTAAC ATTTCACAAA AAGTACTCTC ACAGGATTTG CAGAATGCCT ATGAGACAGT GTTATGAAAA AGGAAAAAAA AGAACAGTGT AGAAAAATTG AATACTTGCT GAGTGAGCAT AGGTGAATGG AAAATGTTAT GGTCATCTGC ATGAAAAAGC AAATCATAGT GTGACAGCAT TAGGGATACA AAAAGATATA GAGAAGGTAT ACATGTATGG TGTAGGTGGG GCATGTACAA AAAGATGACA AGTAGAATCG GGATTTATTC TAAAGAATAG CCTGTAAGGT GTCCAGAAGC CACATTCTAG TCTTGAGTCT GCCTCTACCT GCTGTGTGCC CTTGAGTACA CCCTTAACCT CCTTGAGCTT CAGAGAGGGA TAATCTTTTT ATTTTATTTT ATTTTATTTT GTrTTGTTTT GTTTTGTTTT GTTTTATGAG ACAGAGTCTC ACTCTGTTGC CCAGGCTGGA GTGCAGTGGT ACAATCTTGG CTTACTGCAT CCTCCACCTC CTGAGTTCAA GCGATTCTCC TTCCTCAGTC TCCTGAATAG CTAGGATTAC AGGTGCACCC CACCACACCC AGCTAATTTT TGTATTTTTA GTAGAGAAGG GGTTTCGCCA TGTTGGCCAG GCTGGTTTTC AAGTCCTGAC CTAAATGATT CATCCACCTC GGCTTCCCAA AGTGCTGGGA TTACAGGCAT GAGCCACCAC GCCTGGCCCA GAGAGGGATG ATCTTTAGAA GCTCGGGATT CTTTCAAGCC CTTTCCTCCT CTCTGAGCTT TCTACTCTCT GATGTCAAAG CATGGTTCCT GGCAGGACCA CCTCACCAGG CTCCCTCCCT CGCTCTCTCC GCAGTGCTCC TTCCAGGACC TGGACCTCTG CCCTCTGGAT GGCGGCATCC AGCTACGAAT CTCCGACCAC CACTACAGCA AGGGCTTCAG GCAGGCCGCG TCAGTTGTTG TGGCCATGGA CAAGCTGAGG AAGATGCTGG TTCCCTGCCC ACAGACCTTC CAGGAGAATG ACCTGAGCAC CTTCTTTCCC TTCATCTTTG AAGAAGGTAG TTAGCCAAGA GCAGGCAGTA GATCTCCACT TGTGTCCTCT TGGAAGTCAT CAAGCCCCAG CCAACTCAAT TCCCCCAGAG CCAAAGCCCT TTAAAGGTAG AAGGCCCAGC GGGGAGACAA AACAAAGAAG GCTGGAAACC AAAGCAATCA TCTCTTTAGT GGAAACTATT CTTAAAGAAG ATCTTGATGG CTACTGACAT TTGCAACTCC CTCACTCTTT CTCAGGGGCC TTTCACTTAC ATTGTCACCA GAGGTTCGTA ACCTCCCTGT GGGCTAGTGT TATGACCATC ACCATTTTAC CTAAGTAGCT CTGTTGCTCG GCCACAGTGA GCAGTAATAG ACCTGAAGCT GGAACCCATG TCTAATAGTG TCAGGTCCAG TGTTCTTAGC CACCCCACTC CCAGCTTCAT CCCTACTGGT GTTGTCATCA GACTTTGACC GTATATGCTC AGGTGTCCTC CAAGAAATCA AATTTTGCCA CCTCGCCTCA CGAGGCCTGC CCTTCTGATT TTATACCTAA ACAACATGTG CTCCACATTT CAGAACCTAT CTTCTTCGAC ACATGGGATA ACGAGGCTTA TGTGCACGAT GCACCTGTAC GATCACTGAA CTGCACGCTC CGGGACTCAC AGCAAAAAAG CTTGGTGATG TCTGGTCCAT ATGAACTGAA AGCTCTCCAC CTCCAGGGAC AGGATATGGA GCAACAAGGT AAATGGAAAC ATCCTGGTTT CCCTGCCTGG CCTCCTGGCA GCTTGCTAAT TCTCCATGTT TTAAACAAAG TAGAAAGTTA ATTTAAGGCA AATGATCAAC ACAAGTGAAA AAAAATATTA AAAAGGAATA TACAAACTTT GGTCCTAGAA ATGGCACATT TGATTGCACT GGCCAGTGCA TTTGTTAACA GGAGTGTGAC CCTGAGAAAT TAGACGGCTC bPl-109 190

AAGCACTCCC AGGACCATGT CCACCCAAGT CTCTTGGGCA TAGTGCAGTG TCAATTCTTC CACAATATGG GGTCATTTGA TGGACATGGC CTAACTGCCT GTGGGTTCTC TCTTCCTGTT GTTGAGGCTG AAACAAGAGT GCTGGAGCGA TAATGTGTCC ATCCCCCTCC CCAGTCTTCC CCCCTTGCCC CAACATCCGT CCCACCCAAT GCCAGGTGGT TCCTTGTAGG GAAATTTTAC CGCCCAGCAG GAACTTATAT CTCTCCGCTG TAACGGGCAA AAGTTTCAAG TGCGGTGAAC CCATCATTAG CTGTGGTGAT CTGCCTGGCA TCGTGCCACA GTAGCCAAAG CCTCTGCACA GGAGTGTGGG CAACTAAGGC TGCTGACTTT GAAGGACAGC CTCACTCAGG GGGAAGCTAT TTGCTCTCAG CCAGGCCAAG AAAATCCTGT TTCTTTGGAA TCGGGTAGTA AGAGTGATCC CAGGGCCTCC AATTGACACT GCTGTGACTG AGGAAGATCA AAATGAGTGT CTCTCTTTGG AGCCACTTTC CCAGCTCAGC CTCTCCTCTC CCAGTTTCTT CCCATGGGCT ACTCTCTGTT CCTGAAACAG TTCTGGTGCC TGATTTCTGG CAGAAGTACA GCTTCACCTC TTTCCTTTCC TTCCACATTG ATCAAGTTGT TCCGCTCCTG TGGATGGGCA CATTGCCAGC CAGTGACACA ATGGCTTCCT TCCTTCCTTC CTTCAGCATT TAAAATGTAG ACCCTCTTTC ATTCTCCGTT CCTACTGCTA TGAGGCTCTG AGAAACCCTC AGGCCTTTGA GGGGAAACCC TAAATCAACA AAATGACCCT GCTATTGTCT GTGAGAAGTC AAGTTATCCT GTGTCTTAGG CCAAGGAACC TCACTGTGGG TTCCCACAGA GGCTACCAAT TACATGTATC CTACTCTCGG GGCTAGGGGT TGGGGTGACC CTGCATGCTG TGTCCCTAAC CACAAGACCC CCTTCTTTCT TCAGTGGTGT TCTCCATGTC CTTTGTACAA GGAGAAGAAA GTAATGACAA AATACCTGTG GCCTTGGGCC TCAAGGAAAA GAATCTGTAC CTGTCCTGCG TGTTGAAAGA TGATAAGCCC ACTCTACAGC TGGAGGTAAG TGAATGCTAT GGAATGAAGC CCTTCTCAGC CTCCTGCTAC CACTTATTCC CAGACAATTC ACCTTCTCCC CGCCCCCATC CCTAGGAAAA GCTGGGAACA GGTCTATTTG ACAAGTTTTG CATTAATGTA AATAAATTTA ACATAATTTT TAACTGCGTG CAACCTTCAA TCCTGCTGCA GAAAATTAAA TCATTTTGCC GATGTTATTA TGTCCTACCA TAGTTACAAC CCCAACAGAT TATATATTGT TAGGGCTGCT CTCATTTGAT AGACACCTTG GGAAATAGAT GACTTAAAGG GTCCCATTAT CACGTCCACT CCACTCCCAA AATCACCACC ACTATCACCT CCAGCTTTCT CAGCAAAAGC TTCATTTCCA AGTTGATGTC ATTCTAGGAC CATAAGGAAA AATACAATAA AAAGCCCCTG GAAACTAGGT ACTTCAAGAA GCTCTAGCTT AATTTTCACC CCCCCAAAAA AAAAAAATTC TCACCTACAT TATGCTCCTC AGCATTTGGC ACTAAGTTTT AGAAAAGAAG AAGGGCTCTT TTAATAATCA CACAGAAAGT TGGGGGCCCA GTTACAACTC AGGAGTCTGG CTCCTGATCA TGTGACCTGC TCGTCAGTTT CCTTTCTGGC CAACCCAAAG AACATCTTTC CCATAGGCAT CTTTGTCCCT TGCCCCACAA AAATTCTTCT TTCTCTTTCG CTGCAGAGTG TAGATCCCAA AAATTACCCA AAGAAGAAGA TGGAAAAGCG ATTTGTCTTC AACAAGATAG AAATCAATAA CAAGCTGGAA TTTGAGTCTG CCCAGTTCCC CAACTGGTAC ATCAGCACCT CTCAAGCAGA AAACATGCCC GTCTTCCTGG GAGGGACCAA AGGCGGCCAG GATATAACTG ACTTCACCAT GCAATTTGTG TCTTCCTAAA GAGAGCTGTA CCCAGAGAGT CCTGTGCTGA ATGTGGACTC AATCCCTAGG GCTGGCAGAA AGGGAACAGA AAGGTTTTTG AGTACGGCTA TAGCCTGGAC TTTCCTGTTG TCTACACCAA TGCCCAACTG CCTGCCTTAG GGTAGTGCTA AGAGGATCTC CTGTCCATCA GCCAGGACAG TCAGCTCTCT CCTTTCAGGG CCAATCCCCA GCCCTTTTGT TGAGCCAGGC CTCTCTCACC TCTCCTACTC ACTTAAAGCC CGCCTGACAG AAACCACGGC CACATTTGGT TCTAAGAAAC CCTCTGTCAT TCGCTCCCAC ATTCTGATGA GCAACCGCTT CCCTATTTAT TTATTTATTT GTTTGTTTGT TTTGATTCAT TGGTCTAATT TATTCAAAGG GGGCAAGAAG TAGCAGTGTC TGTAAAAGAG CCTAGTTTTT AATAGCTATG GAATCAATTC AATTTGGACT GGTGTGCTCT CTTTAAATCA AGTCCTTTAA TTAAGACTGA AAATATATAA GCTCAGATTA TTTAAATGGG AATATTTATA AATGAGCAAA TATCATACTG TTCAATGGTT CTGAAATAAA CTTCACTGAA GAAAAAAAAA AAAGGGTCTC TCCTGATCAT TGACTGTCTG GATTGACACT GACAGTAAGC AAACAGGCTG TGAGAGTTCT TGGGACTAAG CCCACTCCTC ATTGCTGAGT GCTGCAAGTA CCTAGAAATA TCCTTGGCCA CCGAAGACTA TCCTCCTCAC CCATCCCCTT TATTTCGTTG TTCAACAGAA GGATATTCAG TGCACATCTG GAACAGGATC AGCTGAAGCA CTGCAGGGAG TCAGGACTGG TAGTAACAGC TACCATGATT TATCTATCAA TGCACCAAAC ATCTGTTGAG CAAGCGCTAT GTACTAGGAG CTGGGAGTAC AGAGATGAGA ACAGTCACAA GTCCCTCCTC AGATAGGAGA GGCAGCTAGT TATAAGCAGA ACAAGGTAAC ATGACAAGTA GAGTAAGATA GAAGAACGAA GAGGAGTAGC CAGGAAGGAG GGAGGAGAAC GACATAAGAA TCAAGCCTAA AGGGATAAAC AGAAGATTTC CACACATGGG CTGGGCCAAT TGGGTGTCGG TTACGCCTGT AATCCCAGCA CTTTGGGTGG CAGGGGCAGA AAGATCGCTT GAGCCCAGGA GTTCAAGACC AGCCTGGGCA ACATAGTGAG ACTCCCATCT CTACAAAAAA TAAATAAATA AATAAAACAA TCAGCCAGGC ATGCTGGCAT GCACCTGTAG TCCTAGCTAC TTGGGAAGCT GACACTGGAG GATTGCTTGA GCCCAGAAGT TCAAGACTGC AGTGAGCTTA TCCGTTGACC TGCAGGTCGA C ACAAACCTTT TCGAGGCAAA AGGCAAAAAA

GGCTGCTCTG GGATTCTCTT CAGCCAATCT TCAATGCTCA AGTGTCTGAA GCAGCCATGG CAGAAGTACC TAAGCTCGCC AGTGAAATGA TGGCTTATTA CAGTGGCAAT GAGGATGACT TGTTCTTTGA AGCTGATGGC CCTAAACAGA TGAAGTGCTC CTTCCAGGAC CTGGACCTCT GCCCTCTGGA TGGCGGCATC CAGCTACGAA TCTCCGACCA CCACTACAGC AAGGGCTTCA GGCAGGCCGC GTCAGTTGTT GTGGCCATGG ACAAGCTGAG GAAGATGCTG GTTCCCTGCC CACAGACCTT CCAGGAGAAT GACCTGAGCA CCTTCTTTCC CTTCATCTTT GAAGAAGAAC CTATCTTCTT CGACACATGG GATAACGAGG CTTATGTGCA CGATGCACCT GTACGATCAC TGAACTGCAC GCTCCGGGAC TCACAGCAAA AAAGCTTGGT GATGTCTGGT CCATATGAAC TGAAAGCTCT CCACCTCCAG GGACAGGATA TGGAGCAACA AGTGGTGTTC TCCATGTCCT TTGTACAAGG AGAAGAAAGT AATGACAAAA TACCTGTGGC CTTGGGCCTC AAGGAAAAGA ATCTGTACCT GTCCTGCGTG TTGAAAGATG ATAAGCCCAC TCTACAGCTG GAGAGTGTAG ATCCCAAAAA TTACCCAAAG AAGAAGATGG AAAAGCGATT TGTCTTCAAC AAGATAGAAA TCAATAACAA GCTGGAATTT GAGTCTGCCC AGTTCCCCAA CTGGTACATC AGCACCTCTC AAGCAGAAAA CATGCCCGTC TTCCTGGGAG GGACCAAAGG CGGCCAGGAT ATAACTGACT TCACCATGCA ATTTGTGTCT TCCTAAAGAG AGCTGTACCC AGAGAGTCCT GTGCTGAATG TGGACTCAAT CCCTAGGGCT GGCAGAAAGG GAACAGAAAG GTTTTTGAGT ACGGCTATAG CCTGGACTTT CCTGTTGTCT ACACCAATGC CCAACTGCCT GCCTTAGGGT AGTGCTAAGA GGATCTCCTG TCCATCAGCC AGGACAGTCA GCTCTCTCCT TTCAGGGCCA ATCCCAGCCC TTTTGTTGAG CCAGGCCTCT CTCACCTCTC CTACTCACTT AAAGCCCGCC TGACAGAAAC CAGGCCACAT TTTGGTTCTA AGAAACCCTC CTCTGTCATT CGCTCCCACA TTCTGATGAG CAACCGCTTC CCTATTTATT TATTTATTTG TTTGTTTGTT TTGATTCATT GGTCTAATTT ATTCAAAGGG GGCAAGAAGT AGCAGTGTCT GTAAAAGAGC CTAGTTTTTA ATAGCTATGG AATCAATTCA ATTTGGACTG GTGTGCTCTC TTTAAATCAA GTCCTTTAAT TAAGACTGAA AATATATAAG CTCAGATTAT TTAAATGGGA ATATTTATAA ATGAGCAAAT ATCATACTGT TCAATGGTTC TCAAATAAAC TTCACT CTGGCAGGAG TAGCAGCTGC CCCTTGGCGC GACTGCTGGA GCCGCGAACT AGAGAAACAC AGACACGCCT CATAGAGCAA CGGCGTCTCT CGGAGCGTGG AGCCCGCCAA GCTCGAGCTG AGCTTTCGCT TGCCGTCCAC CACTGCCCAC ACTGTCGTTT GCTGCCATCG CAGACCTGCT GCTGACTTCC ATCCCTCTGG ATCCGGCAAG GGCCTGCGAT TTTGACAATG TCAAGATTTA CCGTATATCC CTGTTTGTTT GGATACACCA GTGACGTCCA CTTCTAGAAG ACAAAGTTAT ATTACTTAAA CAACCAAAGA TATGAAACTA TCCATGAAGA ACAATATTAT CAATACACAG CAGTCTTTTG TAACCATGCC CAATGTGATT GTACCAGATA TTGAAAAGGA AATACGAAGG ATGGAAAATG GAGCATGCAG CTCCTTTTCT GAGGATGATG ACAGTGCCTC TACATCTGAA GAATCAGAGA ATGAAAACCC TCATGCAAGG GGTTCCTTTA GTTATAAGTC bPI-109 191

ACTCAGAAAG GGAGGACCAT CACAGAGGGA GCAGTACCTG CCTGGTGCCA TTGCCATTTT TAATGTGAAC AACAGCGACA ATAAGGACCA GGAACCAGAA GAAAAAAAGA AAAAGAAAAA AGAAAAGAAG AGCAAGTCAG ATGATAAAAA CGAAAATAAA AACGACCCAA AGAAGAAGAT GGAAAAGCGA ATGGCCAAAG TTCCAGACAT GTTTGAAGAC

CTGAAGAACT GTTACAGTGA AAATGAAGAA GACAGTTCCT CCATTGATCA TCTGTCTCTG AATCAGAAAT CCTTCTATCA TGTAAGCTAT GGCCCACTCC ATGAAGGCTG CATGGATCAA TCTGTGTCTC TGAGTATCTC TGAAACCTCT AAAACATCCA AGCTTACCTT CAAGGAGAGC ATGGTGGTAG TAGCAACCAA CGGGAAGGTT CTGAAGAAGA GACGGTTGAG TTTAAGCCAA TCCATCACTG ATGATGACCT GGAGGCCATC GCCAATGACT CAGAGGAAGA AATCATCAAG CCTAGGTCAG CACCTTTTAG CTTCCTGAGC AATGTGAAAT ACAACTTTAT GAGGATCATC AAATACGAAT TCATCCTGAA TGACGCCCTC AATCAAAGTA TAATTCGAGC CAATGATCAG TACCTCACGG CTGCTGCATT ACATAATCTG GATGAAGCAG TGAAATTTGA CATGGGTGCT TATAAGTCAT CAAAGGATGA TGCTAAAATT ACCGTGATTC TAAGAATCTC AAAAACTCAA TTGTATGTGA CTGCCCAAGA TGAAGACCAA CCAGTGCTGC TGAAGGAGAT GCCTGAGATA CCCAAAACCA TCACAGGTAG TGAGACCAAC CTCCTCTTCT TCTGGGAAAC TCACGGCACT AAGAACTATT TCACATCAGT TGCCCATCCA AACTTGTTTA TTGCCACAAA GCAAGACTAC TGGGTGTGCT TGGCAGGGGG GCCACCCTCT ATCACTGACT TTCAGATACT GGAAAACCAG GCGTAGGTCT GGAGTCTCAC TTGTCTCACT TGTGCAGTGT TGACAGTTCA TATGTACCAT GTACATGAAG AAGCTAAATC CTTTACTGTT AGTCATTTGC TGAGCATGTA CTGAGCCTTG TAATTCTAAA TGAATGTTTA CACTCTTTGT AAGAGTGGAA CCAACACTAA CATATAATGT TGTTATTTAA AGAACACCCT ATATTTTGCA TAGTACCAAT CATTTTAATT ATTATTCTTC ATAACAATTT TAGGAGGACC AGAGCTACTG ACTATGGCTA CCAAAAAGAC TCTACCCATA TTACAGATGG GCAAATTAAG GCATAAGAAA ACTAAGAAAT ATGCACAATA GCAGTTGAAA CAAGAAGCCA CAGACCTAGG ATTTCATGAT TTCATTTCAA CTGTTTGCCT TCTGCTTTTA AGTTGCTGAT GAACTCTTAA TCAAATAGCA TAAGTTTCTG GGACCTCAGT TTTATCATTT TCAAAATGGA GGGAATAATA CCTAAGCCTT CCTGCCGCAA CAGTTTTTTA TGCTAATCAG GGAGGTCATT TTGGTAAAAT ACTTCTCGAA GCCGAGCCTC AAGATGAAGG CAAAGCACGA AATGTTATTT TTTAATTATT ATTTATATAT GTATTTATAA ATATATTTAA GATAATTATA ATATACTATA TTTATGGGAA CCCCTTCATC CTCTGAGTGT GACCAGGCAT CCTCCACAAT AGCAGACAGT GTTTTCTGGG ATAAGTAAGT TTGATTTCAT TAATACAGGG CATTTTGGTC CAAGTTGTGC TTATCCCATA GCCAGGAAAC TCTGCATTCT AGTACTTGGG AGACCTGTAA TCATATAATA AATGTACATT AATTACCTTG AGCCAGTAAT TGGTCCGATC TTTGACTCTT TTGCCATTAA ACTTACCTGG GCATTCTTGT TTCATTCAAT TCCACCTGCA ATCAAGTCCT ACAAGCTAAA ATTAGATGAA CTCAACTTTG ACAACCATAG ACCACTGTTA TCAAAACTTT CTTTTCTGGA ATGTAATCAA TGTTTCTTCT AGGTTCTAAA AATTGTGATC AGACCATAAT GTTACATTAT TATCAACAAT AGTGATTGAT AGAGTGTTAT CAGTCATAAC TAAATAAAGC TTGCAAGTGA GGGAGTCATT TCATTGGCGT TTGAGTCAGC AAAGAAGTCA AG AGCTGCCAGC CAGAGAGGGA

GTCATTTCAT TGGCGTTTGA GTCAGCAAAG AAGTCAAGAT GGCCAAAGTT CCAGACATGT TTGAAGACCT GAAGAACTGT TACAGTGAAA ATGAAGAAGA CAGTTCCTCC ATTGATCATC TGTCTCTGAA TCAGAAATCC TTCTATCATG TAAGCTATGG CCCACTCCAT GAAGGCTGCA TGGATCAATC TGTGTCTCTG AGTATCTCTG AAACCTCTAA AACATCCAAG CTTACCTTCA AGGAGAGCAT GGTGGTAGTA GCAACCAACG GGAAGGTTCT GAAGAAGAGA CGGTTGAGTT TAAGCCAATC CATCACTGAT GATGACCTGG AGGCCATCGC CAATGACTCA GAGGAAGAAA TCATCAAGCC TAGGTCATCA CCTTTTAGCT TCCTGAGCAA TGTGAAATAC AACTTTATGA GGATCATCAA ATACGAATTC ATCCTGAATG ACGCCCTCAA TCAAAGTATA ATTCGAGCCA ATGATCAGTA CCTCACGGCT GCTGCATTAC ATAATCTGGA TGAAGCAGTG AAATTTGACA TGGGTGCTTA TAAGTCATCA AAGGATGATG CTAAAATTAC CGTGATTCTA AGAATCTCAA AAACTCAATT GTATGTGACT GCCCAAGATG AAGACCAACC AGTGCTGCTG AAGGAGATGC CTGAGATACC CAAAACCATC ACAGGTAGTG AGACCAACCT CCTCTTCTTC TGGGAAACTC ACGGCACTAA GAACTATTTC ACATCAGTTG CCCATCCAAA CTTGTTTATT GCCACAAAGC AAGACTACTG GGTGTGCTTG GCAGGGGGGC CACCCTCTAT CACTGACTTT CAGATACTGG AAAACCAGGC GTAGGTCTGG AGTCTCACTT GTCTCACTTG TGCAGTGTTG ACAGTTCATA TGTACCATGT ACATGAAGAA GCTAAATCCT TTACTGTTAG TCATTTGCTG AGCATGTACT GAGCCTTGTA ATTCTAAATG AATGTTTACA CTCTTTGTAA GAGTGGAACC AACACTAACA TATAATGTTG TTATTTAAAG AACACCCTAT ATTTTGCATA GTACCAATCA TTTTAATTAT TATTCTTCAT AACAATTTTA GGAGGACCAG AGCTACTGAC TATGGCTACC AAAAAGACTC TACCCATATT ACAGATGGGC AAATTAAGGC ATAAGAAAAC TAAGAAATAT GCACAATAGC AGTCGAAACA AGAAGCCACA GACCTAGGAT TTCATGATTT CATTTCAACT GTTTGCCTTC TGCTTTTAAG TTGCTGATGA ACTCTTAATC AAATAGCATA AGTTTCTGGG ACCTCAGTTT TATCATTTTC AAAATGGAGG GAATAATACC TAAGCCTTCC TGCCGCAACA GTTTTTTATG CTAATCAGGG AGGTCATTTT GGTAAAATAC TTCTCGAAGC CGAGCCTCAA GATGAAGGCA AAGCACGAAA TGTTATTTTT TAATTATTAT TTATATATGT ATTTATAAAT ATATTTAAGA TAATTATAAT ATACTATATT TATGGGAACC CCTTCATCCT CTGAGTGTGA CCAGGCATCC TCCACAATAG CAGACAGTGT TTTCTGGGAT AAGTAAGTTT GATTTCATTA ATACAGGGCA TTTTGGTCCA AGTTGTGCTT ATCCCATAGC CAGGAAACTC TGCATTCTAG TACTTGGGAG ACCTGTAATC ATATAATAAA TGTACATTAA TTACCTTGAG CCAGTAATTG GTCCGATCTT TGACTCTTTT GCCATTAAAC TTACCTGGGC ATTCTTGTTT CATTCAATTC CACCTGCAAT CAAGTCCTAC AAGCTAAAAT TAGATGAACT CAACTTTGAC AACCATGAGA CCACTGTTAT CAAAACTTTC TTTTCTGGAA TGTAATCAAT GTTTCTTCTA GGTTCTAAAA ATTGTGATCA GACCATAATG TTACATTATT ATCAACAATA GTGATTGATA GAGTGTTATC AGTCATAACT AAATAAAGCT TGCAACAAAA TTCTCTG-3^■ (FRAG. NO:_)(SEQ. ID NO:2517)

5'-AAGCTTCTAC CCTAGTCTGG TGCTACACTT ACATTGCTTA CATCCAAGTG TGGTTATTTC TGTGGCTCCT GTTATAACTA TTATAGCACC AGGTCTATGA CCAGGAGAAT TAGACTGGCA TTAAATCAGA ATAAGAGATT TTGCACCTGC AATAGACCTT ATGACACCTA ACCAACCCCA TTATTTACAA TTAAACAGGA ACAGAGGGAA TACTTTATCC AACTCACACA AGCTGTTTTC CTCCCAGATC CATGCTTTTT TGCGTTTATT ATTTTTTAGA GATGGGGGCT TCACTATGTT GCCCACACTG GACTAAAACT CTGGGCCTCA AGTGATTGTC CTGCCTCAGC CTCCTGAATA GCTGGGACTA CAGGGGCATG CCATCACACC TAGTTCATTT CCTCTATTTA AAATATACAT GGCTTAAACT CCAACTGGGA ACCCAAAACA TTCATTTGCT AAGAGTCTGG TGTTCTACCA CCTGAACTAG GCTGGCCACA GGAATTATAA AAGCTGAGAA ATTCTTTAAT AATAGTAACC AGGCAACATC ATTGAAGGCT CATATGTAAA AATCCATGCC TTCCTTTCTC CCAATCTCCA TTCCCAAACT TAGCCACTGG TTCTGGCTGA GGCCTTACGC ATACCTCCCG GGGCTTGCAC ACACCTTCTT CTACAGAAGA CACACCTTGG GCATATCCTA CAGAAGACCA GGCTTCTCTC TGGTCCTTGG TAGAGGGCTA CTTTACTGTA ACAGGGCCAG GGTGGAGAGT TCTCTCCTGA AGCTCCATCC CCTCTATAGG AAATGTGTTG ACAATATTCA GAAGAGTAAG AGGATCAAGA CTTCTTTGTG CTCAAATACC ACTGTTCTCT TCTCTACCCT GCCCTAACCA GGAGCTTGTC ACCCCAAACT CTGAGGTGAT TTATGCCTTA ATCAAGCAAA CTTCCCTCTT CAGAAAAGAT GGCTCATTTT CCCTCAAAAG TTGCCAGGAG CTGCCAAGTA TTCTGCCAAT TCACCCTGGA GCACAATCAA CAAATTCAGC CAGAACACAA CTACAGCTAC TATTAGAACT ATTATTATTA ATAAATTCCT CTCCAAATCT AGCCCCTTGA CTTCGGATTT CACGATTTCT CCCTTCCTCC TAGAAACTTG ATAAGTTTCC CGCGCTTCCC TTTTTCTAAG ACTACATGTT TGTCATCTTA bPl-109 192

TAAAGCAAAG GGGTGAATAA ATGAACCAAA TCAATAACTT CTGGAATATC TGCAAACAAC AATAATATCA GCTATGCCAT CTTTCACTAT TTTAGCCAGT ATCGAGTTGA ATGAACATAG AAAAATACAA AACTGAATTC TTCCCTGTAA ATTCCCCGTT TTGACGACGC ACTTGTAGCC ACGTAGCCAC GCCTACTTAA GACAATTACA AAAGGCGAAG AAGACTGACT CAGGCTTAAG CTGCCAGCCA GAGAGGGAGT CATTTCATTG GCGTTTGAGT CAGCAAAGGT ATTGTCCTCA CATCTCTGGC TATTAAAGTA TTTTCTGTTG TTGTTTTTCT CTTTGGCTGT TTTCTCTCAC ATTGCCTTCT CTAAAGCTAC AGTCTCTCCT TTCTTTTCTT GTCCCTCCCT GGTTTGGTAT GTGACCTAGA ATTACAGTCA GATTTCAGAA AATGATTCTC TCATTTTGCT GATAAGGACT GATTCGTTTT ACTGAGGGAC GGCAGAACTA GTTTCCTATG AGGGCATGGG TGAATACAAC TGAGGCTTCT CATGGGAGGG AATCTCTACT ATCCAAAATT ATTAGGAGAA AATTGAAAAT TTCCAACTCT GTCTCTCTCT TACCTCTGTG TAAGGCAAAT ACCTTATTCT TGTGGTGTTT TTGTAACCTC TTCAAACTTT CATTGATTGA ATGCCTGTTC TGGCAATACA TTAGGTTGGG CACATAAGGA ATACCAACAT AAATAAAACA TTCTAAAAGA AGTTTACGAT CTAATAAAGG AGACAGGTAC ATAGCAAACT AATTCAAAGG AGCTAGAAGA TGGAGAAAAT GCTGAATGTG GACTAAGTCA TTCAACAAAG TTTTCAGGAA GCACAAAGAG GAGGGGCTCC CCTCACAGAT ATCTGGATTA GAGGCTGGCT GAGCTGATGG TGGCTGGTGT TCTCTGTTGC AGAAGTCAAG ATGGCCAAAG TTCCAGACAT GTTTGAAGAC CTGAAGAACT GTTACAGGTA AGGAATAAGA TTTATCTCTT GTGATTTAAT GAGGGTTTCA AGGCTCACCA GAATCCAGCT AGGCATAACA GTGGCCAGCA TGGGGGCAGG CCGGCAGAGG TTGTAGAGAT GTGTACTAGT CCTGAAGTCA GAGCAGGTTC AGAGAAGACC CAGAAAAACT AAGCATTCAG CATGTTAAAC TGAGATTACA TTGGCAGGGA GACCGCCATT TTAGAAAAAT TATTTTTGAG GTCTGCTGAG CCCTACATGA ATATCAGCAT CAACTTAGAC ACAGCCTCTG TTGAGATCAC ATGCCCTGAT ATAAGAATGG GTTTTACTGG TCCATTCTCA GGAAAACTTG ATCTCATTCA GGAACAGGAA ATGGCTCCAC AGCAAGCTGG GCATGTGAAC TCACATATGC AGGCAAATCT CACTCAGATG TAGAAGAAAG GTAAATGAAC ACAAAGATAA AATTACGGAA CATATTAAAC TAACATGATG TTTCCATTAT CTGTAGTAAA TACTAACACA AACTAGGCTG TCAAAATTTT GCCTGGATAT TTTACTAAGT ATAAATTATG AAATCTGTTT TAGTGAATAC ATGAAAGTAA TGTGTAACAT ATAATCTATT TGGTTAAAAT AAAAAGGAAG TGCTTCAAAA CCTTTCTTTT CTCTAAAGGA GCTTAACATT CTTCCCTGAA CTTCAATTAA AGCTCTTCAA TTTGTTAGCC AAGTCCAATT TTTACAGATA AAGCACAGGT AAAGCTCAAA GCCTGTCTTG ATGACTACTA ATTCCAGATT AGTAAGATAT GAATTACTCT ACCTATGTGT ATGTGTAGAA GTCCTTAAAT TTCAAAGATG ACAGTAATGG CCATGTGTAT GTGTGTGACC CACAACTATC ATGGTCATTA AAGTACATTG GCCAGAGACC ACATGAAATA ACAACAATTA CATTCTCATC ATCTTATTTT GACAGTGAAA ATGAAGAAGA CAGTTCCTCC ATTGATCATC TGTCTCTGAA TCAGGTAAGC AAATGACTGT AATTCTCATG GGACTGCTAT TCTTACACAG TGGTTTCTTC ATCCAAAGAG AACAGCAATG ACTTGAATCT TAAATACTTT TGTTTTACCC TCACTAGAGA TCCAGAGACC TGTCTTTCAT TATAAGTGAG ACCAGCTGCC TCTCTAAACT AATAGTTGAT GTGCATTGGC TTCTCCCAGA ACAGAGCAGA ACTATCCCAA ATCCCTGAGA ACTGGAGTCT CCTGGGGCAG GCTTCATCAG GATGTTAGTT ATGCCATCCT GAGAAAGCCC CGCAGGCCGC TTCACCAGGT GTCTGTCTCC TAACGTGATG TGTTGTGGTT GTCTTCTCTG ACACCAGCAT CAGAGGTTAG AGAAAGTCTC CAAACATGAA GCTGAGAGAG AGGAAGCAAG CCAGCTGAAA GTGAGAAGTC TACAGCCACT CATCAATCTG TGTTATTGTG TTTGGAGACC ACAAATAGAC ACTATAAGTA CTGCCTAGTA TGTCTTCAGT ACTGGCTTTA AAAGCTGTCC CCAAAGGAGT ATTTCTAAAA TATTTTGAGC ATTGTTAAGC AGATTTTTAA CCTCCTGAGA GGGAACTAAT TGGAAAGCTA CCACTCACTA CAATCATTGT TAACCTATTT AGTTACAACA TCTCATTTTT GAGCATGCAA ATAAATGAAA AAGTCTTCCT AAAAAAATCA TCTTTTTATC CTGGAAGGAG GAAGGAAGGT GAGACAAAAG GGAGAGAGGG AGGGAAGCCT AATGAAACAC CAGTTACCTA AGACCAGAAT GGAGATCCTC CTCACTACCT CTGTTGAATA CAGCACCTAC TGAAAGAACT TTCATTCCCT GACCATGAAC AGCCTCTCAG CTTCTGTTTT CCTTCCTCAC AGAAATCCTT CTATCATGTA AGCTATGGCC CACTCCATGA AGGCTGCATG GATCAATCTG TGTCTCTGAG TATCTCTGAA ACCTCTAAAA CATCCAAGCT TACCTTCAAG GAGAGCATGG TGGTAGTAGC AACCAACGGG AAGGTTCTGA AGAAGAGACG GTTGAGTTTA AGCCAATCCA TCACTGATGA TGACCTGGAG GCCATCGCCA ATGACTCAGA GGAAGGTAAG GGGTCAAGCA CAATAATATC TTTCTTTTAC AGTTTTAAGC AAGTAGGGAC AGTAGAATTT AGGGGAAAAT TAAACGTGGA GTCAGAATAA CAAGAAGACA ACCAAGCATT AGTCTGGTAA CTATACAGAG GAAAATTAAT TTTTATCCTT CTCCAGGAGG GAGAAATGAG CAGTGGCCTG AATCGAGAAT ACTTGCTCAC AGCCATTATT TCTTAGCCAT ATTGTAAAGG TCGTGTGACT TTTAGCCTTT CAGGAGAAAG CAGTAATAAG ACCACTTACG AGCTATGTTC CTCTCATACT AACTATGCCT CCTTGGTCAT GTTACATAAT CTTTTCGTGA TTCAGTTTCC TCTACTGTAA AATGGAGATA ATCAGAATCC CCCACTCATT GGATTGTTGT AAAGATTAAG AGTCTCAGGC TTTACAGACT GAGCTAGCTG GGCCCTCCTG ACTGTTATAA AGATTAAATG AGTCAACATC CCCTAACTTC TGGACTAGAA TAATGTCTGG TACAAAGTAA GCACCCAATA AATGTTAGCT ATTACTATCA TTATTATTAT TATTTTATTT TTTTTTTTTG AGATGGAGTC TGGCTCTGTC ACCCAGGCTG GAGTGCAGTG GCACAATCTC GGCTCACTGC AAGCTCTGCC TCCTGGGTTC ATGCCATTCT CCTGCCTCAG CCTCCCGAGT AAGCTGGGAA TACAGGCACC CGCCACTGTT CCCGGCTAAT TTTTTGTATT TTTAGTAGAG ACGGAGTTTC ACCGTGGTCT CCATCTCCTC GTGATCCACC CACCTTGGCC TCCCAAAGTG CCGGGATTAC AGGCGTGAGC CACCGCGCCC GGCCTATTAT TATTATTATT ACTACTACTA CTACCTATAT GAATACTACC AGCAATACTA ATTTATTAAT GACTGGATTA TGTCTAAACC TCACAAGAAT CCTACCTTCT CATTTTACAT AAAAGGAAAC TAAGCTCATT GAGATAGGTA AACTGCCCAA TGGCATACAT CTGTAAGTGG GAGAGCCTCA AATCTAATTC AGTTCTACCT GAGTAAAAAA ATCATGGTTT CTCCTCCATC CCTTTACTGT ACAAGCCTCC ACATGAACTA TAAACCCAAT ATTCCTGTTT TTAAGATAAT ACCTAAGCAA TAACGCATGT TCACCTAGAA GGTTTTAAAA TGTAACAAAA TATAAGAAAA TAAAAATCAC TCATATCGTC AGTGAGAGTT TACTACTGCC AGCACTATGG TATGTTTCCT TAAAATCTTT GCTATACACA TACCTACATG TGAACAAATA TGTCTAACAT CAAGACCACA CTATTTACAA CTTTATATCC AGCTTTTCTT ACTTAGCAAT GTATTGAGGA CATTTTAGAG TGCCCGTTTT TCACCATTAT AAGCAATGCA ACAATGAACA TCTGTATAAA TAAATATTCA TTTCTCTCAC CCTTTATTTC CTTAGAATAT ATTCCTAGAA GTAGAATTTC CCAGAGCCAT GAGGATTTGT GACGCTATTG ATATGTGCCA CTTTGCACTC TCTGTGACAT ATATAATTAT TTTTAATGCA TTCATTTTTT TCTCAGAGTG CATTCGTTTG AAAACATAGA CGGGAAATAC TGGTAGTCTT CCTTGTCAGT TAGAAACACC CAAACAATGA AAAATGAAAA AGTTGCACAA ATAGTCTCTA AAAACAATGA AACTATTGCC TGAGGAATTG AAGTTTAAAA AGAAGCACAT AAGCAACAAC AAGGATAATC CTAGAAAACC AGTTCTGCTG ACTGGGTGAT TTCACTTCTC TTTGCTTCCT CATCTGGATT GGAATATTCC TAATACCCCC TCCAGAACTA TTTTCCCTGT TTGTACTAGA CTGTGTATAT CATCTGTGTT TGTACATAGA CATTAATCTG CACTTGTGAT CATGGTTTTA GAAATCATCA AGCCTAGGTC ATCACCTTTT AGCTTCCTGA GCAATGTGAA ATACAACTTT ATGAGGATCA TCAAATACGA ATTCATCCTG AATGACGCCC TCAATCAAAG TATAATTCGA GCCAATGATC AGTACCTCAC GGCTGCTGCA TTACATAATC TGGATGAAGC AGGTACATTA AAATGGCACC AGACATTTCT GTCATCCTCC CCTCCTTTCA TTTACTTATT TATTTATTTC AATCTTTCTG CTTGCAAAAA ACATACCTCT TCAGAGTTCT GGGTTGCACA ATTCTTCCAG AATAGCTTGA AGCACAGCAC CCCCATAAAA ATCCCAAGCC AGGGCAGAAG GTTCAACTAA ATCTGGAAGT TCCACAAGAG AGAAGTTTCC TATCTTTGAG AGTAAAGGGT TGTGCACAAA GCTAGCTGAT GTACTACCTC TTTGGTTCTT bHI-109 193

TCAGACATTC TTACCCTCAA TTTTAAAACT GAGGAAACTG TCAGACATAT TAAATGATTT ACTCAGATTT ACCCAGAAGC CAATGAAGAA CAATCACTCT CCTTTAAAAA GTCTGTTGAT CAAACTCACA AGTAACACCA AACCAGGAAG ATCTTTATTA TCTCTGATAA CATATTTGTG AGGCAAAACC TCCAATAAGC TACAAATATG GCTTAAAGGA TGAAGTTTAG TGTCCAAAAA CTTTTATCAC ACACATCCAA TTTTCATGGC GGACATGTTT TAGTTTCAAC AGTATACATA TTTTCAAAGG TCCAGAGAGG CAATTTTGCA ATAAACAAGC AAGACTTTTT CTGATTGGAT GCACTTCAGC TAACATGCTT TCAACTCTAC ATTTACAAAT TATTTTGTGT TCTATTTTTC TACTTAATAT TATTTCTGCA ATTTTCCCAA TATTGACATC GTGTATGTAT TTGCCATTTT TAATATCACT AGACAATTCA ATCAGGTTGC TACGTTGGTC CCTTGGGTTT ACTCTAAATA GCTTGATTGC AAATATCTTT GTATATATTA TTGTTTTTTC TCCTATCTTG TAATTTCTTT GAGCACATCC CAAAGAGGAA TGCCTAGATC AATGGGCACA AATAATTTGA CAGCTCTTAT TAAACATTAT TCTGTAAGTA AAAACTGAAC TACTTTTCAG TATCACTAGC AACATATGAG TGTATCAGCT TCCTAAACCC CTCCATGTTA GGTCATTATG AACTTATGAT CTAACAAATT ACAGGGTCTT ATCCCACTAA TGAAATTATA AGAGATTCAA CACTTATTCA GCCCCGAAGG ATTCATTCAA CGTAGAAAAT TCTAAGAACA TTAACCAAGT ATTTACCTGC CTAGTGAGTG TGGAAGACAT TGTGAAGGAC ACAAAGATGT ATAGAATTCC ATTCCTGACT TCCAGGTATT TACACCATAG GTGGGGACCT AACTACACAC ACACACACAC ACACACACAC ACACACACAC ACCATGCACA CACAATCTAC ATCAACACTT GATTTTATAC AAATACAATG AATTTACTTT CTTTTTGGTT CTTCTCTTCA CCAGTGAAAT TTGACATGGG TGCTTATAAG TCATCAAAGG ATGATGCTAA AATTACCGTG ATTCTAAGAA TCTCAAAAAC TCAATTGTAT GTGACTGCCC AAGATGAAGA CCAACCAGTG CTGCTGAAGG TCAGTTGTCC TTTGTCTCCA ACTTACCTTC ATTTACATCT CATATGTTTG TAAATAAGCC CAATAGGCAG ACACCTCTAA CAAGGTGACA CTGTCCTCTT TCCTTCCTAC CACAGCCCCC ACCTACCCAC CCCACTCCCA TTGATTCCAG AGGCGTGCCT AGGCAGGATC TATGAGAAAA TATAACAGAG AGTAAGAGGA AAATTACCTT CTTTCTTTTT CCTTTCCCTG CCTGACCTTA TTCACCTCCC ATCCCAGAGC ATCCATTTAT TCCATTCATC TTTACTGACA TCTATTATCT GACCTACACA ATACTAGACA TTAGGACAAT GTGGCCTGCC TCCAAGAAAC TCAAATAAGC CAACTGAGAT CAGAGAGGAT TAATCACCTG CCAATGGGCA CAAAGCAACA AGCTGGGAGC CAAGTCCCAA AATGGGGCCT GCTGCTTCCA GTTCCCCTCT CTCTGCATTG ATGTCAGCAT TATCCTTCGT CCCAGTCCTG TCTCCACTAC CACTTTCCCC CTCAAACACA CACACACACA ACAGCCTTAG ATGTTTTCTC CACTGATAAG TAGGTGACTC AATTTGTAAG TATATAATCC AAGACCTTCT ATTCCCAAGT AGAATTTATG TGCCTGCCTG TGCTTTTCTA CCTGGATCAA GTGATGTCTA CAGAGTAGGG CAGTAGCTTC ATTCATGAAC TCATTCAACA AGCATTATTC ACTGAGAGCC TTGTATTTTT CAGGCATAGT GCCAACAGCA GTGTGGACAG TGGTGCATCA AAGCCTCTAG TCTCATAGAA CTTAGTCTTC TGGAGGATAT GGAAAACAGA CAACCCAAAC AACCAACAAA AGAGCAAGAT GCTGCAAAAA AAAAAAAAAT GAATAGGGTG CTAAGATAGA GAAAAGTGGG AGAGTGCTAT TTAGACAAAG TGGTAAAAAC AAAGCCCCTT GTGAGATGAG AGCTGCCGAC AGAGGGGGCG GGTCATGGTT GTGGGTTTTT GGGTAGGACA TTCAGAGGAG GGGGCGGGTC GTGGTTGTGG GTTTTTGGGT AGGACATTCA GAGGAGGGGG CGGGTCGTGG TTGTGGGTTT TTGGGTAGGA CATTCAGAGG AGGGGGCGGG TCGTGGTTGT GGGTTTTTGG GTAGGACATT CAGAGGAGGG GGCGGGTCGT GGTTGTGGGT TTTTGGGACA TTCAGAGGAG TCTGAATGCA CCCAGGCCTA CAACTTCAAG ATGGTAAAGG ACAGCTCCAA GGATCAGAAG AAGCATTCTT GGAACTGGGG CATTTTGAGA AGGAGGAAAA ATATGCAGAG ACTAGTGCTT GCAGAGCTTG CATTTGGATT TCATTTGAGG TACAATGAAA ACCCATTAAT GGGTTTCACA CAGTGCAATG GCCTGACCTC ACTTATATTT CCTAAAATAG AAAACAGATC AGAAGGAAGG CAATAGAGAA GCAGAAAGTC CAATGAGGAG GTTTCACAGC AGTCATGGGG GTGGGGTAAG GAAAAGAAGT GGAAAGAAAC AGACAGAATT GGGTTATATT TTGGAGATAG AACCAACAGA AGGAAGAGGA GAAACAACAT TTACTGAGAA GGGAAAAAGT AGGAGAGGAA TAGGTTTGGG AAATAAATCC TGCTGACATT GGAAACCCCA AGGAAGCCTC AAAAGTATAT TTACTTGCTT TAGATTTAAA AGAATAGGAA AGAAGCATCT CAACTTGGAA TTTGAAATCT ATΠTTCCAT AAAAGTATTG TTAAATTCTA CTCATACTCA CAAGAAAAGT ACATTCTAAA GAGTATATTG AAAGAGTTTA CTGATATACT TAGGAATTTT GTGTGTATGT GTGTGTGTGT ATGTGTGTGT GTGTGTTTAA CCTTCAATTG TTGACTTAAA TACTGAGATA AATGTCATCT AAATGCTAAA TTCATTTCCC AAAGGTATGA TTTGTTCACT TGGAGATCAA AATGTTTAGG GGGCTTAGAA TCACTGTAGT GCTCAGATTT GATGCAAAAT GTCTTAGGCC TATGTTGAAG GCAGGACAGA AACAATGTTT CCCTCCTACC TGCCTGGATA CAGTAAGATA CTAGTGTCAC TGACAATCTT CATAACTAAT TTAGATCTCT CTCCAATCAA CTAAGGAAAT CAACTCTTAT TAATAGACTG GGCCACACAT CTACTAGGCA TGTAATAAAT GCTTGCTGAA TGAACAAATG AATGAAGAGC CTATAGCATC ATGTTACAGC CATAGTCCTA AAGTGGTGTT TCTCATGAAG GCCAAATGCT AAGGGATTGA GCTTCAGTCC TTTTTCTAAC ATCTTGTTCT CTAACAGAAT TCTCTTCTTT TCTTCATAGG AGATGCCTGA GATACCCAAA ACCATCACAG GTAGTGAGAC CAACCTCCTC TTCTTCTGGG AAACTCACGG CACTAAGAAC TATTTCACAT CAGTTGCCCA TCCAAACTTG TTTATTGCCA CAAAGCAAGA CTACTGGGTG TGCTTGGCAG GGGGGCCACC CTCTATCACT GACTTTCAGA TACTGGAAAA CCAGGCGTAG GTCTGGAGTC TCACTTGTCT CACTTGTGCA GTGTTGACAG TTCATATGTA CCATGTACAT GAAGAAGCTA AATCCTTTAC TGTTAGTCAT TTGCTGAGCA TGTACTGAGC CTTGTAATTC TAAATGAATG TTTACACTCT TTGTAAGAGT GGAACCAACA CTAACATATA ATGTTGTTAT TTAAAGAACA CCCTATATTT TGCATAGTAC CAATCATTTT AATTATTATT CTTCATAACA ATTTTAGGAG GACCAGAGCT ACTGACTATG GCTACCAAAA AGACTCTACC CATATTACAG ATGGGCAAAT TAAGGCATAA GAAAACTAAG AAATATGCAC AATAGCAGTT GAAACAAGAA GCCACAGACC TAGGATTTCA TGATTTCATT TCAACTGTTT GCCTTCTGCT TTTAAGTTGC TGATGAACTC TTAATCAAAT AGCATAAGTT TCTGGGACCT CAGTTTTATC ATTTTCAAAA TGGAGGGAAT AATACCTAAG CCTTCCTGCC GCAACAGTTT TTTATGCTAA TCAGGGAGGT CATTTTGGTA AAATACTTCT CGAAGCCGAG CCTCAAGATG AAGGCAAAGC ACGAAATGTT ATTTTTTAAT TATTATTTAT ATATGTATTT ATAAATATAT TTAAGATAAT TATAATATAC TATATTTATG GGAACCCCTT CATCCTCTGA GTGTGACCAG GCATCCTCCA CAATAGCAGA CAGTGTTTTC TGGGATAAGT AAGTTTGATT TCATTAATAC AGGGCATTTT GGTCCAAGTT GTGCTTATCC CATAGCCAGG AAACTCTGCA TTCTAGTACT TGGGAGACCT GTAATCATAT AATAAATGTA CATTAATTAC CTTGAGCCAG TAATTGGTCC GATCTTTGAC TCTTTTGCCA TTAAACTTAC CTGGGCATTC TTGTTTCATT CAATTCCACC TGCAATCAAG TCCTACAAGC TAAAATTAGA TGAACTCAAC TTTGACAACC ATGAGACCAC TGTTATCAAA ACTTTCTTTT CTGGAATGTA ATCAATGTTT CTTCTAGGTT CTAAAAATTG TGATCAGACC ATAATGTTAC ATTATTATCA ACAATAGTGA TTGATAGAGT GTTATCAGTC ATAACTAAAT AAAGCTTGCA ACAAAATTCT CTGACACATA GTTATTCATT GCCTTAATCA TTATTTTACT GCATGGTAAT TAGGGACAAA TGGTAAATGT TTACATAAAT AATTGTATTT AGTGTTACTT TATAAAATCA AACCAAGATT TTATATTTTT TTCTCCTCTT TGTTAGCTGC CAGTATGCAT AAATGGCATT AAGAATGATA ATATTTCCGG GTTCACTTAA AGCTCATATT ACACATACAC AAAACATGTG TTCCCATCTT TATACAAACT CACACATACA GAGCTACATT AAAAACAACT AATAGGCCAG GCACGGTGGC TCAGACCTGT AATCCCAGCA CTTTGGGAGG- 3 ' ( FRAG . NO : _) ( SEQ . ID NO : 2510 )

5'-ACCAACCTCT TCGAGGCACA AGGCACAACA GGCTGCTCTG GGATTCTCTT CAGCCAATCT TCATTGCTCA AGTGTCTGAA GCAGCCATGG CAGAAGTACC TGAGCTCGCC AGTGAAATGA TGGCTTATTA CAGTGGCAAT GAGGATGACT TGTTCTTTGA bPI-109 194

AGCTGATGGC CCTAAACAGA TGAAGTGCTC CTTCCAGGAC CTGGACCTCT GCCCTCTGGA TGGCGGCATC CAGCTACGAA TCTCCGACCA CCACTACAGC AAGGGCTTCA GGCAGGCCGC GTCAGTTGTT GTGGCCATGG ACAAGCTGAG GAAGATGCTG GTTCCCTGCC CACAGACCTT CCAGGAGAAT GACCTGAGCA CCTTCTTTCC CTTCATCTTT GAAGAAGAAC CTATCTTCTT CGACACATGG GATAACGAGG CTTATGTGCA CGATGCACCT GTACGATCAC TGAACTGCAC GCTCCGGGAC TCACAGCAAA AAAGCTTGGT GATGTCTGGT CCATATGAAC TGAAAGCTCT CCACCTCCAG GGACAGGATA TGGAGCAACA AGTGGTGTTC TCCATGTCCT TTGTACAAGG AGAAGAAAGT AATGACAAAA TACCTGTGGC CTTGGGCCTC AAGGAAAAGA ATCTGTACCT GTCCTGCGTG TTGAAAGATG ATAAGCCCAC TCTACAGCTG GAGAGTGTAG ATCCCAAAAA TTACCCAAAG AAGAAGATGG AAAAGCGATT TGTCTTCAAC AAGATAGAAA TCAATAACAA GCTGGAATTT GAGTCTGCCC AGTTCCCCAA CTGGTACATC AGCACCTCTC AAGCAGAAAA CATGCCCGTC TTCCTGGGAG GGACCAAAGG CGGCCAGGAT ATAACTGACT TCACCATGCA ATTTGTGTCT TCCTAAAGAG AGCTGTACCC AGAGAGTCCT GTGCTGAATG TGGACTCAAT CCCTAGGGCT GGCAGAAAGG GAACAGAAAG GTTTTTGAGT ACGGCTATAG CCTGGACTTT CCTGTTGTCT ACACCAATGC CCAACTGCCT GCCTTAGGGT AGTGCTAAGA GGATCTCCTG TCCATCAGCC AGGACAGTCA GCTCTCTCCT TTCAGGGCCA ATCCCCAGCC CTTTTGTTGA GCCAGGCCTC TCTCACCTCT CCTACTCACT TAAAGCCCGC CTGACAGAAA CCACGGCCAC ATTTGGTTCT AAGAAACCCT CTGTCATTCG CTCCCACATT CTGATGAGCA ACCGCTTCCC TATTTATTTA TTTATTTGTT TGTTTGTTTT ATTCATTGGT CTAATTTATT CAAAGGGGGC AAGAAGTAGC AGTGTCTGTA AAAGAGCCTA GTTTTTAATA GCTATGGAAT CAATTCAATT TGGACTGGTG TGCTCTCTTT AAATCAAGTC CTTTAATTAA GACTGAAAAT ATATAAGCTC AGATTATTTA AATGGGAATA TTTATAAATG AGCAAATATC ATACTGTTCA ATGGTTCTGA AATAAACTTC TCTGAAG-3' (FRAG. NO: (SEQ. ID NO:2511) 5'-AGAAAGAAAG AGAGAGAGAA AGAAAAGAAA GAGGAAGGAA GGAAGGAAGG AAGAAAGACA GGCTCTGAGG AAGGTGGCAG TTCCTACAAC GGGAGAACCA GTGGTTAATT TGCAAAGTGG ATCCTGTGGA GGCANNCAGA GGAGTCCCCT AGGCCACCCA GACAGGGCTT TTAGCTATCT GCAGGCCAGA CACCAAATTT CAGGAGGGCT CAGTGTTAGG AATGGATTAT GGCTTATCAA ATTCACAGGA AACTAACATG TTGAACAGCT TTTAGATTTC CTGTGGAAAA TATAACTTAC TAAAGATGGA GTTCTTGTGA CTGACTCCTG ATATCAAGAT ACTGGGAGCC AAATTAAAAA TCAGAAGGCT GCTTGGAGAG CAAGTCCATG AAATGCTCTT TTTCCCACAG TAGAACCTAT TTCCCTCGTG TCTCAAATAC TTGCACAGAG GCTCACTCCC TTGGATAATG CAGAGCGAGC ACGATACCTG GCACATACTA ATTTGAATAA AATGCTGTCA AATTCCCATT CACCCATTCA AGCAGCAAAC TCTATCTCAC CTGAATGTAC ATGCCAGGCA CTGTGCTAGA CTTGGCTCAA AAAGATTTCA GTTTCCTGGA GGAACCAGGA GGGCAAGGTT TCAACTCAGT GCTATAAGAA GTGTTACAGG CTGGACACGG TGGCTCACGC CTGTAATCCC AACATTTGGG AGGCCGAGGC GGGCAGATCA CAAGGTCAGG AGATCGAGAC CATCCTGGCT AACATGGTGA AACCCTGTCT CTACTAAAAA TACAAAAAAT TAGCCGGGCG TTGGCGGCAG GTGCCTGTAG TCCCAGCTGC TGGGGAGGCT GAGGCAGGAG AATGGTGTGA ACCCGGGAGG CGGAACTTGC AGGGGGCCGA GATCGTGCCA CTGCACTCCA GCCTGGGCGA CAGAGTGAGA CTCTGTCTCA AAAAAAAAAA AAAAGTGTTA TGATGCAGAC CTGTCAAAGA GGCAAAGGAG GGTGTTCCTA CACTCCAGGC ACTGTTCATA ACCTGGACTC TCATTCATTC TACAAATGGA GGGCTCCCCT GGGCAGATCC CTGGAGCAGG CACTTTGCTG GTGTCTCGGT TAAAGAGAAA CTGATAACTC TTGGTATTAC CAAGAGATAG AGTCTCAGAT GGATATTCTT ACAGAAACAA TATTCCCACT TTTCAGAGTT CACCAAAAAA TCATTTTAGG CAGAGCTCAT CTGGCATTGA TCTGGTTCAT CCATGAGATT GGCTAGGGTA ACAGCACCTG GTCTTGCAGG GTTGTGTGAG CTTATCTCCA GGGTTGCCCC AACTCCGTCA GGAGCCTGAA CCCTGCATAC CGTATGTTCT CTGCCCCAGC CAAGAAAGGT CAATTTTCTC CTCAGAGGCT CCTGCAATTG ACAGAGAGCT CCCGAGGCAG AGAACAGCAC CCAAGGTAGA GACCCACACC CTCAATACAG ACAGGGAGGG CTATTGGCCC TTCATTGTAC CCATTTATCC ATCTGTAAGT GGGAAGATTC CTAAACTTAA GTACAAAGAA GTGAATGAAG AAAAGTATGT GCATGTATAA ATCTGTGTGT CTTCCACTTT GTCCCACATA TACTAAATTT AAACATTCTT CTAACGTGGG AAAATCCAGT ATTTTAATGT GGACATCAAC TGCACAACGA TTGTCAGGAA AACAATGCAT ATTTGCATGG TGATACATTT GCAAAATGTG TCATAGTTTG CTACTCCTTG CCCTTCCATG AACCAGAGAA TTATCTCAGT TTATTAGTCC CCTCCCCTAA GAAGCTTCCA CCAATACTCT TTTCCCCTTT CCTTTAACTT GATTGTGAAA TCAGGTATTC AACAGAGAAA TTTCTCAGCC TCCTACTTCT GCTTTTGAAA GCTATAAAAA CAGCGAGGGA GAAACTGGCA GATACCAAAC CTCTTCGAGG CACAAGGCAC AACAGGCTGC TCTGGGATTC TCTTCAGCCA ATCTTCATTG CTCAAGTATG ACTTTAATCT TCCTTACAAC TAGGTGCTAA GGGAGTCTCT CTGTCTCTCT GCCTCTTTGT GTGTATGCAT ATTCTCTCTC TCTCTCTCTT TCTTTCTCTG TCTCTCCTCT CCTTCCTCTC TGCCTCCTCT CTCAGCTTTT TGCAAAAATG CCAGGTGTAA TATAATGCTT ATGACTCGGG AAATATTCTG GGAATGGATA CTGCTTATCT AACAGCTGAC ACCCTAAAGG TTAGTGTCAA AGCCTCTGCT CCAGCTCTCC TAGCCAATAC ATTGCTAGTT GGGGTTTGGT TTAGCAAATG CTTTTCTCTA GACCCAAAGG ACTTCTCTTT CACACATTCA TTCATTTACT CAGAGATCAT TTCTTTGCAT GACTGCCATG CACTGGATGC TGAGAGAAAT CACACATGAA CGTAGCCGTC ATGGGGAAGT CACTCATTTT CTCCTTTTTA CACAGGTGTC TGAAGCAGCC ATGGCAGAAG TACCTGAGCT CGCCAGTGAA ATGATGGCTT ATTACAGGTC AGTGGAGACG CTGAGACCAG TAACATGAGC AGGTCTCCTC TTTCAAGAGT AGAGTGTTAT CTGTGCTTGG AGACCAGATT TTTCCCCTAA ATTGCCTCTT TCAGTGGCAA ACAGGGTGCC AAGTAAATCT GATTTAAAGA CTACTTTCCC ATTACAAGTC CCTCCAGCCT TGGGACCTGG AGGCTATCCA GATGTGTTGT TGCAAGGGCT TCCTGCAGAG GCAAATGGGG AGAAAAGATT CCAAGCCCAC AATACAAGGA ATCCCTTTGC AAAGTGTGGC TTGGAGGGAG AGGGAGAGCT CAGATTTTAG CTGACTCTGC TGGGCTAGAG GTTAGGCCTC AAGATCCAAC AGGGAGCACC AGGGTGCCCA CCTGCCAGGC CTAGAATCTG CCTTCTGGAC TGTTCTGCGC ATATCACTGT GAAACTTGCC AGGTGTTTCA GGCAGCTTTG AGAGGCAGGC TGTTTGCAGT TTCTTATGAA CAGTCAAGTC TTGTACACAG GGAAGGAAAA ATAAACCTGT TTAGAAGACA TAATTGAGAC ATGTCCCTGT TTTTATTACA GTGGCAATGA GGATGACTTG TTCTTTGAAG CTGATGGCCC TAAACAGATG AAGGTAAGAC TATGGGTTTA ACTCCCAACC CAAGGAAGGG CTCTAACACA GGGAAAGCTC AAAGAAGGGA GTTCTGGGCC ACTTTGATGC CATGGTATTT TGTTTTAGAA AGACTTTAAC CTCTTCCAGT GAGACACAGG CTGCACCACT TGCTGACCTG GCCACTTGGT CATCATATCA CCACAGTCAC TCACTAACGT TGGTGGTGGT GGCCACACTT GGTGGTGACA GGGGAGGAGT AGTGATAATG TTCCCATTTC ATAGTAGGAA GACAACCAAG TCTTCAACAT AAATTTGATT ATCCTTTTAA GAGATGGATT CAGCCTATGC CAATCACTTG AGTTAAACTC TGAAACCAAG AGATGATCTT GAGAACTAAC ATATGTCTAC CCCTTTTGAG TAGAATAGTT TTTTGCTACC TGGGGTGAAG CTTATAACAA CAAGACATAG ATGATATAAA CAAAAAGATG AATTGAGACT TGAAAGAAAA CCATTCACTT GCTGTTTGAC CTTGACAAGT CATTTTACCC GCTTTGGACC TCATCTGAAA AATAAAGGGC TGAGCTGGAT GATCTCTGAG ATTCCAGCAT CCTGCAACCT CCAGTTCTGA AATATTTTCA GTTGTAGCTA AGGGCATTTG GGCAGCAAAT GGTCATTTTT CAGACTCATC CTTACAAAGA GCCATGTTAT ATTCCTGCTG TCCCTTCTGT TTTATATGAT GCTCAGTAGC CTTCCTAGGT GCCCAGCCAT CAGCCTAGCT AGGTCAGTTG TGCAGGTTGG AGGCAGCCAC TTTTCTCTGG CTTTATTTTA TTCCAGTTTG TGATAGCCTC CCCTAGCCTC ATAATCCAGT CCTCAATCTT GTTAAAAACA TATTTCTTTA GAAGTTTTAA GACTGGCATA ACTTCTTGGC TGCAGCTGTG GGAGGAGCCC ATTGGCTTGT CTGCCTGGCC TTTGCCCCCC ATTGCCTCTT CCAGCAGCTT GGCTCTGCTC CAGGCAGGAA ATTCTCTCCT EPI-109 195

GCTCAACTTT CTTTTGTGCA CTTACAGGTC TCTTTAACTG TCTTTCAAGC CTTTGAACCA TTATCAGCCT TAAGGCAACC TCAGTGAAGC CTTAATACGG AGCTTCTCTG AATAAGAGGA AAGTGGTAAC ATTTCACAAA AAGTACTCTC ACAGGATTTG CAGAATGCCT ATGAGACAGT GTTATGAAAA AGGAAAAAAA AGAACAGTGT AGAAAAATTG AATACTTGCT GAGTGAGCAT AGGTGAATGG AAAATGTTAT GGTCATCTGC ATGAAAAAGC AAATCATAGT GTGACAGCAT TAGGGATACA AAAAGATATA GAGAAGGTAT ACATGTATGG TGTAGGTGGG GCATGTACAA AAAGATGACA AGTAGAATCG GGATTTATTC TAAAGAATAG CCTGTAAGGT GTCCAGAAGC CACATTCTAG TCTTGAGTCT GCCTCTACCT GCTGTGTGCC CTTGAGTACA CCCTTAACCT CCTTGAGCTT CAGAGAGGGA TAATCTTTTT ATTTTATTTT ATTTTATTTT GTTTTGTTTT GTTTTGTTTT GTTTTATGAG ACAGAGTCTC ACTCTGTTGC CCAGGCTGGA GTGCAGTGGT ACAATCTTGG CTTACTGCAT CCTCCACCTC CTGAGTTCAA GCGATTCTCC TTCCTCAGTC TCCTGAATAG CTAGGATTAC AGGTGCACCC CACCACACCC AGCTAATTTT TGTATTTTTA GTAGAGAAGG GGTTTCGCCA TGTTGGCCAG GCTGGTTTTG AAGTCCTGAC CTAAATGATT CATCCACCTC GGCTTCCCAA AGTGCTGGGA TTACAGGCAT GAGCCACCAC GCCTGGCCCA GAGAGGGATG ATCTTTAGAA GCTCGGGATT CTTTCAAGCC CTTTCCTCCT CTCTGAGCTT TCTACTCTCT GATGTCAAAG CATGGTTCCT GGCAGGACCA CCTCACCAGG CTCCCTCCCT CGCTCTCTCC GCAGTGCTCC TTCCAGGACC TGGACCTCTG CCCTCTGGAT GGCGGCATCC AGCTACGAAT CTCCGACCAC CACTACAGCA AGGGCTTCAG GCAGGCCGCG TCAGTTGTTG TGGCCATGGA CAAGCTGAGG AAGATGCTGG TTCCCTGCCC ACAGACCTTC CAGGAGAATG ACCTGAGCAC CTTCTTTCCC TTCATCTTTG AAGAAGGTAG TTAGCCAAGA GCAGGCAGTA GATCTCCACT TGTGTCCTCT TGGAAGTCAT CAAGCCCCAG CCAACTCAAT TCCCCCAGAG CCAAAGCCCT TTAAAGGTAG AAGGCCCAGC GGGGAGACAA AACAAAGAAG GCTGGAAACC AAAGCAATCA TCTCTTTAGT GGAAACTATT CTTAAAGAAG ATCTTGATGG CTACTGACAT TTGCAACTCC CTCACTCTTT CTCAGGGGCC TTTCACTTAC ATTGTCACCA GAGGTTCGTA ACCTCCCTGT GGGCTAGTGT TATGACCATC ACCATTTTAC CTAAGTAGCT CTGTTGCTCG GCCACAGTGA GCAGTAATAG ACCTGAAGCT GGAACCCATG TCTAATAGTG TCAGGTCCAG TGTTCTTAGC CACCCCACTC CCAGCTTCAT CCCTACTGGT GTTGTCATCA GACTTTGACC GTATATGCTC AGGTGTCCTC CAAGAAATCA AATTTTGCCA CCTCGCCTCA CGAGGCCTGC CCTTCTGATT TTATACCTAA ACAACATGTG CTCCACATTT CAGAACCTAT CTTCTTCGAC ACATGGGATA ACGAGGCTTA TGTGCACGAT GCACCTGTAC GATCACTGAA CTGCACGCTC CGGGACTCAC AGCAAAAAAG CTTGGTGATG TCTGGTCCAT ATGAACTGAA AGCTCTCCAC CTCCAGGGAC AGGATATGGA GCAACAAGGT AAATGGAAAC ATCCTGGTTT CCCTGCCTGG CCTCCTGGCA GCTTGCTAAT TCTCCATGTT TTAAACAAAG TAGAAAGTTA ATTTAAGGCA AATGATCAAC ACAAGTGAAA AAAAATATTA AAAAGGAATA TACAAACTTT GGTCCTAGAA ATGGCACATT TGATTGCACT GGCCAGTGCA TTTGTTAACA GGAGTGTGAC CCTGAGAAAT TAGACGGCTC AAGCACTCCC AGGACCATGT CCACCCAAGT CTCTTGGGCA TAGTGCAGTG TCAATTCTTC CACAATATGG GGTCATTTGA TGGACATGGC CTAACTGCCT GTGGGTTCTC TCTTCCTCTT GTTGAGGCTG AAACAAGAGT GCTGGAGCGA TAATGTGTCC ATCCCCCTCC CCAGTCTTCC CCCCTTGCCC CAACATCCGT CCCACCCAAT GCCAGGTGGT TCCTTGTAGG GAAATTTTAC CGCCCAGCAG GAACTTATAT CTCTCCGCTG TAACGGGCAA AAGTTTCAAG TGCGGTGAAC CCATCATTAG CTGTGGTGAT CTGCCTGGCA TCGTGCCACA GTAGCCAAAG CCTCTGCACA GGAGTGTGGG CAACTAAGGC TGCTGACTTT GAAGGACAGC CTCACTCAGG GGGAAGCTAT TTGCTCTCAG CCAGGCCAAG AAAATCCTGT TTCTTTGGAA TCGGGTAGTA AGAGTGATCC CAGGGCCTCC AATTGACACT GCTGTGACTG AGGAAGATCA AAATGAGTGT CTCTCTTTGG AGCCACTTTC CCAGCTCAGC CTCTCCTCTC CCAGTTTCTT CCCATGGGCT ACTCTCTGTT CCTGAAACAG TTCTGGTGCC TGATTTCTGG CAGAAGTACA GCTTCACCTC TTTCCTTTCC TTCCACATTG ATCAAGTTGT TCCGCTCCTG TGGATGGGCA CATTGCCAGC CAGTGACACA ATGGCTTCCT TCCTTCCTTC CTTCAGCATT TAAAATGTAG ACCCTCTTTC ATTCTCCGTT CCTACTGCTA TGAGGCTCTG AGAAACCCTC AGGCCTTTGA GGGGAAACCC TAAATCAACA AAATGACCCT GCTATTGTCT GTGAGAAGTC AAGTTATCCT GTGTCTTAGG CCAAGGAACC TCACTGTGGG TTCCCACAGA GGCTACCAAT TACATGTATC CTACTCTCGG GGCTAGGGGT TGGGGTGACC CTGCATGCTG TGTCCCTAAC CACAAGACCC CCTTCTTTCT TCAGTGGTGT TCTCCATGTC CTTTGTACAA GGAGAAGAAA GTAATGACAA AATACCTGTG GCCTTGGGCC TCAAGGAAAA GAATCTGTAC CTGTCCTGCG TGTTGAAAGA TGATAAGCCC ACTCTACAGC TGGAGGTAAG TGAATGCTAT GGAATGAAGC CCTTCTCAGC CTCCTGCTAC CACTTATTCC CAGACAATTC ACCTTCTCCC CGCCCCCATC CCTAGGAAAA GCTGGGAACA GGTCTATTTG ACAAGTTTTG CATTAATGTA AATAAATTTA ACATAATTTT TAACTGCGTG CAACCTTCAA TCCTGCTGCA GAAAATTAAA TCATTTTGCC GATGTTATTA TGTCCTACCA TAGTTACAAC CCCAACAGAT TATATATTGT TAGGGCTGCT CTCATTTGAT AGACACCTTG GGAAATAGAT GACTTAAAGG GTCCCATTAT CACGTCCACT CCACTCCCAA AATCACCACC ACTATCACCT CCAGCTTTCT CAGCAAAAGC TTCATTTCCA AGTTGATGTC ATTCTAGGAC CATAAGGAAA AATACAATAA AAAGCCCCTG GAAACTAGGT ACTTCAAGAA GCTCTAGCTT AATTTTCACC CCCCCAAAAA AAAAAAATTC TCACCTACAT TATGCTCCTC AGCATTTGGC ACTAAGTΠT AGAAAAGAAG AAGGGCTCTT TTAATAATCA CACAGAAAGT TGGGGGCCCA GTTACAACTC AGGAGTCTGG CTCCTGATCA TGTGACCTGC TCGTCAGTTT CCTTTCTGGC CAACCCAAAG AACATCTTTC CCATAGGCAT CTTTGTCCCT TGCCCCACAA AAATTCTTCT TTCTCTTTCG CTGCAGAGTG TAGATCCCAA AAATTACCCA AAGAAGAAGA TGGAAAAGCG ATTTGTCTTC AACAAGATAG AAATCAATAA CAAGCTGGAA TTTGAGTCTG CCCAGTTCCC CAACTGGTAC ATCAGCACCT CTCAAGCAGA AAACATGCCC GTCTTCCTGG GAGGGACCAA AGGCGGCCAG GATATAACTG ACTTCACCAT GCAATTTGTG TCTTCCTAAA GAGAGCTGTA CCCAGAGAGT CCTGTGCTGA ATGTGGACTC AATCCCTAGG GCTGGCAGAA AGGGAACAGA AAGGTTTTTG AGTACGGCTA TAGCCTGGAC TTTCCTGTTG TCTACACCAA TGCCCAACTG CCTGCCTTAG GGTAGTGCTA AGAGGATCTC CTGTCCATCA GCCAGGACAG TCAGCTCTCT CCTTTCAGGG CCAATCCCCA GCCCTTTTGT TGAGCCAGGC CTCTCTCACC TCTCCTACTC ACTTAAAGCC CGCCTGACAG AAACCACGGC CACATTTGGT TCTAAGAAAC CCTCTGTCAT TCGCTCCCAC ATTCTGATGA GCAACCGCTT CCCTATTTAT TTATTTATTT GTTTGTTTGT TTTGATTCAT TGGTCTAATT TATTCAAAGG GGGCAAGAAG TAGCAGTGTC TGTAAAAGAG CCTAGTTTTT AATAGCTATG GAATCAATTC AATTTGGACT GGTGTGCTCT CTTTAAATCA AGTCCTTTAA TTAAGACTGA AAATATATAA GCTCAGATTA TTTAAATGGG AATATTTATA AATGAGCAAA TATCATACTG TTCAATGGTT CTGAAATAAA CTTCACTGAA GAAAAAAAAA AAAGGGTCTC TCCTGATCAT TGACTGTCTG GATTGACACT GACAGTAAGC AAACAGGCTG TGAGAGTTCT TGGGACTAAG CCCACTCCTC ATTGCTGAGT GCTGCAAGTA CCTAGAAATA TCCTTGGCCA CCGAAGACTA TCCTCCTCAC CCATCCCCTT TATTTCGTTG TTCAACAGAA GGATATTCAG TGCACATCTG GAACAGGATC AGCTGAAGCA CTGCAGGGAG TCAGGACTGG TAGTAACAGC TACCATGATT TATCTATCAA TGCACCAAAC ATCTGTTGAG CAAGCGCTAT GTACTAGGAG CTGGGAGTAC AGAGATGAGA ACAGTCACAA GTCCCTCCTC AGATAGGAGA GGCAGCTAGT TATAAGCAGA ACAAGGTAAC ATGACAAGTA GAGTAAGATA GAAGAACGAA GAGGAGTAGC CAGGAAGGAG GGAGGAGAAC GACATAAGAA TCAAGCCTAA AGGGATAAAC AGAAGATTTC CACACATGGG CTGGGCCAAT TGGGTGTCGG TTACGCCTGT AATCCCAGCA CTTTGGGTGG CAGGGGCAGA AAGATCGCTT GAGCCCAGGA GTTCAAGACC AGCCTGGGCA ACATAGTGAG ACTCCCATCT CTACAAAAAA TAAATAAATA AATAAAACAA TCAGCCAGGC ATGCTGGCAT GCACCTGTAG TCCTAGCTAC TTGGGAAGCT GACACTGGAG EPI-109 196

GATTGCTTGA GCCCAGAAGT TCAAGACTGC AGTGAGCTTA TCCGTTGACC TGCAGGTCGA C-3' (FRAG. NO:_)(SEQ. ID NO:2512)

5'-ACAAACCTTT TCGAGGCAAA AGGCAAAAAA GGCTGCTCTG GGATTCTCTT CAGCCAATCT TCAATGCTCA AGTGTCTGAA GCAGCCATGG CAGAAGTACC TAAGCTCGCC AGTGAAATGA TGGCTTATTA CAGTGGCAAT GAGGATGACT TGTTCTTTGA AGCTGATGGC CCTAAACAGA TGAAGTGCTC CTTCCAGGAC CTGGACCTCT GCCCTCTGGA TGGCGGCATC CAGCTACGAA TCTCCGACCA CCACTACAGC AAGGGCTTCA GGCAGGCCGC GTCAGTTGTT GTGGCCATGG ACAAGCTGAG GAAGATGCTG GTTCCCTGCC CACAGACCTT CCAGGAGAAT GACCTGAGCA CCTTCTTTCC CTTCATCTTT GAAGAAGAAC CTATCTTCTT CGACACATGG GATAACGAGG CTTATGTGCA CGATGCACCT GTACGATCAC TGAACTGCAC GCTCCGGGAC TCACAGCAAA AAAGCTTGGT GATGTCTGGT CCATATGAAC TGAAAGCTCT CCACCTCCAG GGACAGGATA TGGAGCAACA AGTGGTGTTC TCCATGTCCT TTGTACAAGG AGAAGAAAGT AATGACAAAA TACCTGTGGC CTTGGGCCTC AAGGAAAAGA ATCTGTACCT GTCCTGCGTG TTGAAAGATG ATAAGCCCAC TCTACAGCTG GAGAGTGTAG ATCCCAAAAA TTACCCAAAG AAGAAGATGG AAAAGCGATT TGTCTTCAAC AAGATAGAAA TCAATAACAA GCTGGAATTT GAGTCTGCCC AGTTCCCCAA CTGGTACATC AGCACCTCTC AAGCAGAAAA CATGCCCGTC TTCCTGGGAG GGACCAAAGG CGGCCAGGAT ATAACTGACT TCACCATGCA ATTTGTGTCT TCCTAAAGAG AGCTGTACCC AGAGAGTCCT GTGCTGAATG TGGACTCAAT CCCTAGGGCT GGCAGAAAGG GAACAGAAAG GTTTTTGAGT ACGGCTATAG CCTGGACTTT CCTGTTGTCT ACACCAATGC CCAACTGCCT GCCTTAGGGT AGTGCTAAGA GGATCTCCTG TCCATCAGCC AGGACAGTCA GCTCTCTCCT TTCAGGGCCA ATCCCAGCCC TTTTGTTGAG CCAGGCCTCT CTCACCTCTC CTACTCACTT AAAGCCCGCC TGACAGAAAC CAGGCCACAT TTTGGTTCTA AGAAACCCTC CTCTGTCATT CGCTCCCACA TTCTGATGAG CAACCGCTTC CCTATTTATT TATTTATTTG TTTGTTTGTT TTGATTCATT GGTCTAATTT ATTCAAAGGG GGCAAGAAGT AGCAGTGTCT GTAAAAGAGC CTAGTTTTTA ATAGCTATGG AATCAATTCA ATTTGGACTG GTGTGCTCTC TTTAAATCAA GTCCTTTAAT TAAGACTGAA AATATATAAG CTCAGATTAT TTAAATGGGA ATATTTATAA ATGAGCAAAT ATCATACTGT TCAATGGTTC TCAAATAAAC TTCACT-3' (FRAG. NO:_)(SEQ. ID NO:2513) 5'-CTGGCAGGAG TAGCAGCTGC CCCTTGGCGC GACTGCTGGA GCCGCGAACT AGAGAAACAC AGACACGCCT CATAGAGCAA CGGCGTCTCT CGGAGCGTGG AGCCCGCCAA GCTCGAGCTG AGCTTTCGCT TGCCGTCCAC CACTGCCCAC ACTGTCGTTT GCTGCCATCG CAGACCTGCT GCTGACTTCC ATCCCTCTGG ATCCGGCAAG GGCCTGCGAT TTTGACAATG TCAAGATTTA CCGTATATCC CTGTTTGTTT GGATACACCA GTGACGTCCA CTTCTAGAAG ACAAAGTTAT ATTACTTAAA CAACCAAAGA TATGAAACTA TCCATGAAGA ACAATATTAT CAATACACAG CAGTCTTTTG TAACCATGCC CAATGTGATT GTACCAGATA TTGAAAAGGA AATACGAAGG ATGGAAAATG GAGCATGCAG CTCCTTTTCT GAGGATGATG ACAGTGCCTC TACATCTGAA GAATCAGAGA ATGAAAACCC TCATGCAAGG GGTTCCTTTA GTTATAAGTC ACTCAGAAAG GGAGGACCAT CACAGAGGGA GCAGTACCTG CCTGGTGCCA TTGCCATTTT TAATGTGAAC AACAGCGACA ATAAGGACCA GGAACCAGAA GAAAAAAAGA AAAAGAAAAA AGAAAAGAAG AGCAAGTCAG ATGATAAAAA CGAAAATAAA AACGACCCAA AGAAGAAGAT GGAAAAGCGA-3' (FRAG. NO:J(SEQ. ID NO:2514)

5'-ATGGCCAAAG TTCCAGACAT GTTTGAAGAC CTGAAGAACT GTTACAGTGA AAATGAAGAA GACAGTTCCT CCATTGATCA TCTGTCTCTG AATCAGAAAT CCTTCTATCA TGTAAGCTAT GGCCCACTCC ATGAAGGCTG CATGGATCAA TCTGTGTCTC TGAGTATCTC TGAAACCTCT AAAACATCCA AGCTTACCTT CAAGGAGAGC ATGGTGGTAG TAGCAACCAA CGGGAAGGTT CTGAAGAAGA GACGGTTGAG TTTAAGCCAA TCCATCACTG ATGATGACCT GGAGGCCATC GCCAATGACT CAGAGGAAGA AATCATCAAG CCTAGGTCAG CACCTTTTAG CTTCCTGAGC AATGTGAAAT ACAACTTTAT GAGGATCATC AAATACGAAT TCATCCTGAA TGACGCCCTC AATCAAAGTA TAATTCGAGC CAATGATCAG TACCTCACGG CTGCTGCATT ACATAATCTG GATGAAGCAG TGAAATTTGA CATGGGTGCT TATAAGTCAT CAAAGGATGA TGCTAAAATT ACCGTGATTC TAAGAATCTC AAAAACTCAA TTGTATGTGA CTGCCCAAGA TGAAGACCAA CCAGTGCTGC TGAAGGAGAT GCCTGAGATA CCCAAAACCA TCACAGGTAG TGAGACCAAC CTCCTCTTCT TCTGGGAAAC TCACGGCACT AAGAACTATT TCACATCAGT TGCCCATCCA AACTTGTTTA TTGCCACAAA GCAAGACTAC TGGGTGTGCT TGGCAGGGGG GCCACCCTCT ATCACTGACT TTCAGATACT GGAAAACCAG GCGTAGGTCT GGAGTCTCAC TTGTCTCACT TGTGCAGTGT TGACAGTTCA TATGTACCAT GTACATGAAG AAGCTAAATC CTTTACTGTT AGTCATTTGC TGAGCATGTA CTGAGCCTTG TAATTCTAAA TGAATGTTTA CACTCTTTGT AAGAGTGGAA CCAACACTAA CATATAATGT TGTTATTTAA AGAACACCCT ATATTTTGCA TAGTACCAAT CATTTTAATT ATTATTCTTC ATAACAATTT TAGGAGGACC AGAGCTACTG ACTATGGCTA CCAAAAAGAC TCTACCCATA TTACAGATGG GCAAATTAAG GCATAAGAAA ACTAAGAAAT ATGCACAATA GCAGTTGAAA CAAGAAGCCA CAGACCTAGG ATTTCATGAT TTCATTTCAA CTGTTTGCCT TCTGCTTTTA AGTTGCTGAT GAACTCTTAA TCAAATAGCA TAAGTTTCTG GGACCTCAGT TTTATCATTT TCAAAATGGA GGGAATAATA CCTAAGCCTT CCTGCCGCAA CAGTTTTTTA TGCTAATCAG GGAGGTCATT TTGGTAAAAT ACTTCTCGAA GCCGAGCCTC AAGATGAAGG CAAAGCACGA AATGTTATTT TTTAATTATT ATTTATATAT GTATTTATAA ATATATTTAA GATAATTATA ATATACTATA TTTATGGGAA CCCCTTCATC CTCTGAGTGT GACCAGGCAT CCTCCACAAT AGCAGACAGT GTTTTCTGGG ATAAGTAAGT TTGATTTCAT TAATACAGGG CATTTTGGTC CAAGTTGTGC TTATCCCATA GCCAGGAAAC TCTGCATTCT AGTACTTGGG AGACCTGTAA TCATATAATA AATGTACATT AATTACCTTG AGCCAGTAAT TGGTCCGATC TTTGACTCTT TTGCCATTAA ACTTACCTGG GCATTCTTGT TTCATTCAAT TCCACCTGCA ATCAAGTCCT ACAAGCTAAA ATTAGATGAA CTCAACTTTG ACAACCATAG ACCACTGTTA TCAAAACTTT CTTTTCTGGA ATGTAATCAA TGTTTCTTCT AGGTTCTAAA AATTGTGATC AGACCATAAT GTTACATTAT TATCAACAAT AGTGATTGAT AGAGTGTTAT CAGTCATAAC TAAATAAAGC TTGCAAGTGA GGGAGTCATT TCATTGGCGT TTGAGTCAGC AAAGAAGTCA AG-3' (FRAG. NO:_)(SEQ. ID NO:2515)

5'-AGCTGCCAGC CAGAGAGGGA GTCATTTCAT TGGCGTTTGA GTCAGCAAAG AAGTCAAGAT GGCCAAAGTT CCAGACATGT TTGAAGACCT GAAGAACTGT TACAGTGAAA ATGAAGAAGA CAGTTCCTCC ATTGATCATC TGTCTCTGAA TCAGAAATCC TTCTATCATG TAAGCTATGG CCCACTCCAT GAAGGCTGCA TGGATCAATC TGTGTCTCTG AGTATCTCTG AAACCTCTAA AACATCCAAG CTTACCTTCA AGGAGAGCAT GGTGGTAGTA GCAACCAACG GGAAGGTTCT GAAGAAGAGA CGGTTGAGTT TAAGCCAATC CATCACTGAT GATGACCTGG AGGCCATCGC CAATGACTCA GAGGAAGAAA TCATCAAGCC TAGGTCATCA CCTTTTAGCT TCCTGAGCAA TGTGAAATAC AACTTTATGA GGATCATCAA ATACGAATTC ATCCTGAATG

ACGCCCTCAA TCAAAGTATA ATTCGAGCCA ATGATCAGTA CCTCACGGCT GCTGCATTAC ATAATCTGGA TGAAGCAGTG AAATTTGACA TGGGTGCTTA TAAGTCATCA AAGGATGATG CTAAAATTAC CGTGATTCTA AGAATCTCAA AAACTCAATT GTATGTGACT GCCCAAGATG AAGACCAACC AGTGCTGCTG AAGGAGATGC CTGAGATACC CAAAACCATC ACAGGTAGTG AGACCAACCT CCTCTTCTTC TGGGAAACTC ACGGCACTAA GAACTATTTC ACATCAGTTG CCCATCCAAA CTTGTTTATT GCCACAAAGC AAGACTACTG GGTGTGCTTG GCAGGGGGGC CACCCTCTAT CACTGACTTT CAGATACTGG AAAACCAGGC GTAGGTCTGG AGTCTCACTT GTCTCACTTG TGCAGTGTTG ACAGTTCATA TGTACCATGT ACATGAAGAA GCTAAATCCT TTACTGTTAG TCATTTGCTG AGCATGTACT GAGCCTTGTA ATTCTAAATG AATGTTTACA CTCTTTGTAA GAGTGGAACC AACACTAACA TATAATGTTG TTATTTAAAG AACACCCTAT ATTTTGCATA GTACCAATCA TTTTAATTAT TATTCTTCAT AACAATTTTA GGAGGACCAG AGCTACTGAC TATGGCTACC AAAAAGACTC TACCCATATT ACAGATGGGC AAATTAAGGC ATAAGAAAAC TAAGAAATAT GCACAATAGC AGTCGAAACA AGAAGCCACA GACCTAGGAT TTCATGATTT CATTTCAACT GTTTGCCTTC TGCTTTTAAG TTGCTGATGA ACTCTTAATC AAATAGCATA AGTTTCTGGG ACCTCAGTTT TATCATTTTC AAAATGGAGG GAATAATACC TAAGCCTTCC TGCCGCAACA GTTTTTTATG CTAATCAGGG AGGTCATTTT GGTAAAATAC TTCTCGAAGC CGAGCCTCAA GATGAAGGCA AAGCACGAAA TGTTATTTTT TAATTATTAT TTATATATGT ATTTATAAAT ATATTTAAGA TAATTATAAT ATACTATATT TATGGGAACC CCTTCATCCT CTGAGTGTGA CCAGGCATCC TCCACAATAG CAGACAGTGT TTTCTGGGAT AAGTAAGTTT GATTTCATTA ATACAGGGCA TTTTGGTCCA AGTTGTGCTT ATCCCATAGC CAGGAAACTC TGCATTCTAG TACTTGGGAG ACCTGTAATC ATATAATAAA TGTACATTAA TTACCTTGAG CCAGTAATTG GTCCGATCTT TGACTCTTTT GCCATTAAAC TTACCTGGGC ATTCTTGTTT CATTCAATTC CACCTGCAAT CAAGTCCTAC AAGCTAAAAT TAGATGAACT CAACTTTGAC AACCATGAGA CCACTGTTAT CAAAACTTTC TTTTCTGGAA TGTAATCAAT GTTTCTTCTA GGTTCTAAAA ATTGTGATCA GACCATAATG TTACATTATT ATCAACAATA GTGATTGATA GAGTGTTATC AGTCATAACT AAATAAAGCT TGCAACAAAA 1^^10-3' (FRAG. NO:_)(SEQ. ID NO:2516) Human Interleukin-1 Receptor (IL-1 R) Nucleic Acids and Anti-sense Oligonucleotide Fragments

5'-GCCACGTGCT GCTGGGTCTC AGTCCTCCAC TTCCCGTGTC CTCTGGAAGT TGTCAGGAGC AATGTTGCGC TTGTACGTGT TGGTAATGGG AGTTTCTGCC TTCACCCTTC AGCCTGCGGC ACACACAGGG GCTGCCAGAA GCTGCCGGTT TCGTGGGAGG CATTACAAGC GGGAGTTCAG GCTGGAAGGG GAGCCTGTAG CCCTGAGGTG CCCCCAGGTG CCCTACTGGT TGTGGGCCTC TGTCAGCCCC CGCATCAACC TGACATGGCA TAAAAATGAC TCTGCTAGGA CGGTCCCAGG AGAAGAAGAG ACACGGATGT GGGCCCAGGA CGGTGCTCTG TGGCTTCTGC CAGCCTTGCA GGAGGACTCT GGCACCTACG TCTGCACTAC TAGAAATGCT TCTTACTGTG ACAAAATGTC CATTGAGCTC AGAGTTTTTG AGAATACAGA TGCTTTCCTG CCGTTCATCT CATACCCGCA AATTTTAACC TTGTCAACCT CTGGGGTATT AGTATGCCCT GACCTGAGTG AATTCACCCG TGACAAAACT GACGTGAAGA TTCAATGGTA CAAGGATTCT CTTCTTTTGG ATAAAGACAA TGAGAAATTT CTAAGTGTGA GGGGGACCAC TCACTTACTC GTACACGATG TGGCCCTGGA AGATGCTGGC TATTACCGCT GTGTCCTGAC ATTTGCCCAT GAAGGCCAGC AATACAACAT CACTAGGAGT ATTGAGCTAC GCATCAAGAA AAAAAAAGAA GAGACCATTC CTGTGATCAT TTCCCCCCTC AAGACCATAT CAGCTTCTCT GGGGTCAAGA CTGACAATCC CGTGTAAGGT GTTTCTGGGA ACCGGCACAC CCTTAACCAC CATGCTGTGG TGGACGGCCA ATGACACCCA CATAGAGAGC GCCTACCCGG GAGGCCGCGT GACCGAGGGG CCACGCCAGG AATATTCAGA AAATAATGAG AACTACATTG AAGTGCCATT GATTTTTGAT CCTGTCACAA GAGAGGATTT GCACATGGAT TTTAAATGTG TTGTCCATAA TACCCTGAGT TTTCAGACAC TACGCACCAC AGTCAAGGAA GCCTCCTCCA CGTTCTCCTG GGGCATTGTG CTGGCCCCAC TTTCACTGGC CTTCTTGGTT TTGGGGGGAA TATGGATGCA CAGACGGTGC AAACACAGAA CTGGAAAAGC AGATGGTCTG ACTGTGCTAT GGCCTCATCA TCAAGACTTT CAATCCTATC CCAAGTGAAA TAAATGGAAT GAAATAATTC AAACACAAAA AAAAAAAAAA AAAAAAAA GCCGGAGCCG ACTCGGAGCG CGCGGCGCGG CCGGGAGGAG CCGAGCGCGC CGGGCGCGGC GTGGGGGCGC CGGCTGCCCC GCGCGCCCAG GGAGCGGCAG GAATGTGACA ATCGCGCGCC CGCACCGTAG CACTCCTCGC TCGGCTCCTA GGGCTCTCGC CCTCTGAGCT GAGCCGGGTT CCGCCCGGGC TGGGATCCCA TCACCCTCCA CGGCCGTCCG TCCAGGTAGA CGCACCCTCT GAAGATGGTG ACTCCCTCCT GAGAAGCTGG ACCCCTTGGT AAAAGACAAG GCCTTCTCCA AGAAGAATAT GAAAGTGTTA CTCAGACTTA TTTGTTTCAT AGCTCTACTG ATTTCTTCTC TGGAGGCTGA TAAATGCAAG GAACGTGAAG AAAAAATAAT TTTAGTGTCA TCTGCAAATG AAATTGATGT TCGTCCCTGT CCTCTTAACC CAAATGAACA CAAAGGCACT ATAACTTGGT ATAAAGATGA CAGCAAGACA CCTGTATCTA CAGAACAAGC CTCCAGGATT CATCAACACA AAGAGAAACT TTGGTTTGTT CCTGCTAAGG TGGAGGATTC AGGACATTAC TATTGCGTGG TAAGAAATTC ATCTTACTGC CTCAGAATTA AAATAAGTGC AAAATTTGTG GAGAATGAGC CTAACTTATG TTATAATGCA CAAGCCATAT TTAAGCAGAA ACTACCCGTT GCAGGAGACG GAGGACTTGT GTGCCCTTAT ATGGAGTTTT TTAAAAATGA AAATAATGAG TTACCTAAAT TACAGTGGTA TAAGGATTGC AAACCTCTAC TTCTTGACAA TATACACTTT AGTGGAGTCA AAGATAGGCT CATCGTGATG AATGTGGCTG AAAAGCATAG AGGGAACTAT ACTTGTCATG CATCCTACAC ATACTTGGGC AAGCAATATC CTATTACCCG GGTAATAGAA TTTATTACTC TAGAGGAAAA CAAACCCACA AGGCCTGTGA TTGTGAGCCC AGCTAATGAG ACAATGGAAG TAGACTTGGG ATCCCAGATA CAATTGATCT GTAATGTCAC CGGCCAGTTG AGTGACATTG CTTACTGGAA GTGGAATGGG TCAGTAATTG ATGAAGATGA CCCAGTGCTA GGGGAAGACT ATTACAGTGT GGAAAATCCT GCAAACAAAA GAAGGAGTAC CCTCATCACA GTGCTTAATA TATCGGAAAT TGAAAGTAGA TTTTATAAAC ATCCATTTAC CTGTTTTGCC AAGAATACAC ATGGTATAGA TGCAGCATAT ATCCAGTTAA TATATCCAGT CACTAATTTC CAGAAGCACA TGATTGGTAT ATGTGTCACG TTGACAGTCA TAATTGTGTG TTCTGTTTTC ATCTATAAAA TCTTCAAGAT TGACATTGTG CTTTGGTACA GGGATTCCTG CTATGATTTT CTCCCAATAA AAGCTTCAGA TGGAAAGACC TATGACGCAT ATATACTGTA TCCAAAGACT GTTGGGGAAG GGTCTACCTC TGACTGTGAT ATTTTTGTGT TTAAAGTCTT GCCTGAGGTC TTGGAAAAAC AGTGTGGATA TAAGCTGTTC ATTTATGGAA GGGATGACTA CGTTGGGGAA GACATTGTTG AGGTCATTAA TGAAAACGTA AAGAAAAGCA GAAGACTGAT TATCATTTTA GTCAGAGAAA CATCAGGCTT CAGCTGGCTG GGTGGTTCAT CTGAAGAGCA AATAGCCATG TATAATGCTC TTGTTCAGGA TGGAATTAAA GTTGTCCTGC TTGAGCTGGA GAAAATCCAA GACTATGAGA AAATGCCAGA ATCGATTAAA TTCATTAAGC AGAAACATGG GGCTATCCGC TGGTCAGGGG ACTTTACACA GGGACCACAG TCTGCAAAGA CAAGGTTCTG GAAGAATGTC AGGTACCACA TGCCAGTCCA GCGACGGTCA CCTTCATCTA AACACCAGTT ACTGTCACCA GCCACTAAGG AGAAACTGCA AAGAGAGGCT CACGTGCCTC TCGGGTAGCA TGGAGAAGTT GCCAAGAGTT CTTTAGGTGC CTCCTGTCTT ATGGCGTTGC AGGCCAGGTT ATGCCTCATG CTGACTTGCA GAGTTCATGG AATGTAACTA TATCATCCTT TATCCCTGAG GTCACCAGGA ATCAGG-3' (FRAG, NO:_)(SEQ. ID NO:2521) EPI-109 198

5'-GCCACGTGCT GCTGGGTCTC AGTCCTCCAC TTCCCGTGTC CTCTGGAAGT TGTCAGGAGC AATGTTGCGC TTGTACGTGT TGGTAATGGG AGTTTCTGCC TTCACCCTTC AGCCTGCGGC ACACACAGGG GCTGCCAGAA GCTGCCGGTT TCGTGGGAGG CATTACAAGC GGGAGTTCAG GCTGGAAGGG GAGCCTGTAG CCCTGAGGTG CCCCCAGGTG CCCTACTGGT TGTGGGCCTC TGTCAGCCCC CGCATCAACC TGACATGGCA TAAAAATGAC TCTGCTAGGA CGGTCCCAGG AGAAGAAGAG ACACGGATGT GGGCCCAGGA CGGTGCTCTG TGGCTTCTGC CAGCCTTGCA GGAGGACTCT GGCACCTACG TCTGCACTAC TAGAAATGCT TCTTACTGTG ACAAAATGTC CATTGAGCTC AGAGTTTTTG AGAATACAGA TGCTTTCCTG CCGTTCATCT CATACCCGCA AATTTTAACC TTGTCAACCT CTGGGGTATT AGTATGCCCT GACCTGAGTG AATTCACCCG TGACAAAACT GACGTGAAGA TTCAATGGTA CAAGGATTCT CTTCTTTTGG ATAAAGACAA TGAGAAATTT CTAAGTGTGA GGGGGACCAC TCACTTACTC GTACACGATG TGGCCCTGGA AGATGCTGGC TATTACCGCT GTGTCCTGAC ATTTGCCCAT GAAGGCCAGC AATACAACAT CACTAGGAGT ATTGAGCTAC GCATCAAGAA AAAAAAAGAA GAGACCATTC CTGTGATCAT TTCCCCCCTC AAGACCATAT CAGCTTCTCT GGGGTCAAGA CTGACAATCC CGTGTAAGGT GTTTCTGGGA ACCGGCACAC CCTTAACCAC CATGCTGTGG TGGACGGCCA ATGACACCCA CATAGAGAGC GCCTACCCGG GAGGCCGCGT GACCGAGGGG CCACGCCAGG AATATTCAGA AAATAATGAG AACTACATTG AAGTGCCATT GATTTTTGAT CCTGTCACAA GAGAGGATTT GCACATGGAT TTTAAATGTG TTGTCCATAA TACCCTGAGT TTTCAGACAC TACGCACCAC AGTCAAGGAA GCCTCCTCCA CGTTCTCCTG GGGCATTGTG CTGGCCCCAC TTTCACTGGC CTTCTTGGTT TTGGGGGGAA TATGGATGCA CAGACGGTGC AAACACAGAA CTGGAAAAGC AGATGGTCTG ACTGTGCTAT GGCCTCATCA TCAAGACTTT CAATCCTATC CCAAGTGAAA TAAATGGAAT GAAATAATTC AAACACAAAA AAAAAAAAAA AAAAAAAA-3' (FRAG. NO:_)(SEQ. ID NO:2518)

S'-GCCGGAGCCG ACTCGGAGCG CGCGGCGCGG CCGGGAGGAG CCGAGCGCGC CGGGCGCGGC GTGGGGGCGC CGGCTGCCCC GCGCGCCCAG GGAGCGGCAG GAATGTGACA ATCGCGCGCC CGCACCGTAG CACTCCTCGC TCGGCTCCTA GGGCTCTCGC CCTCTGAGCT GAGCCGGGTT CCGCCCGGGC TGGGATCCCA TCACCCTCCA CGGCCGTCCG TCCAGGTAGA CGCACCCTCT GAAGATGGTG ACTCCCTCCT GAGAAGCTGG ACCCCTTGGT AAAAGACAAG GCCTTCTCCA AGAAGAATAT GAAAGTGTTA CTCAGACTTA TTTGTTTCAT AGCTCTACTG ATTTCTTCTC TGGAGGCTGA TAAATGCAAG GAACGTGAAG AAAAAATAAT TTTAGTGTCA TCTGCAAATG AAATTGATGT TCGTCCCTGT CCTCTTAACC CAAATGAACA CAAAGGCACT ATAACTTGGT ATAAAGATGA CAGCAAGACA CCTGTATCTA CAGAACAAGC CTCCAGGATT CATCAACACA AAGAGAAACT TTGGTTTGTT CCTGCTAAGG TGGAGGATTC AGGACATTAC TATTGCGTGG TAAGAAATTC ATCTTACTGC CTCAGAATTA AAATAAGTGC AAAATTTGTG GAGAATGAGC CTAACTTATG TTATAATGCA CAAGCCATAT TTAAGCAGAA ACTACCCGTT GCAGGAGACG GAGGACTTGT GTGCCCTTAT ATGGAGTTTT TTAAAAATGA AAATAATGAG TTACCTAAAT TACAGTGGTA TAAGGATTGC AAACCTCTAC TTCTTGACAA TATACACTTT AGTGGAGTCA AAGATAGGCT CATCGTGATG AATGTGGCTG AAAAGCATAG AGGGAACTAT ACTTGTCATG CATCCTACAC ATACTTGGGC AAGCAATATC CTATTACCCG GGTAATAGAA TTTATTACTC TAGAGGAAAA CAAACCCACA AGGCCTGTGA TTGTGAGCCC AGCTAATGAG ACAATGGAAG TAGACTTGGG ATCCCAGATA CAATTGATCT GTAATGTCAC CGGCCAGTTG AGTGACATTG CTTACTGGAA GTGGAATGGG TCAGTAATTG ATGAAGATGA CCCAGTGCTA GGGGAAGACT ATTACAGTGT GGAAAATCCT GCAAACAAAA GAAGGAGTAC CCTCATCACA GTGCTTAATA TATCGGAAAT TGAAAGTAGA TTTTATAAAC ATCCATTTAC CTGTTTTGCC AAGAATACAC ATGGTATAGA TGCAGCATAT ATCCAGTTAA TATATCCAGT CACTAATTTC CAGAAGCACA TGATTGGTAT ATGTGTCACG TTGACAGTCA TAATTGTGTG TTCTGTTTTC ATCTATAAAA TCTTCAAGAT TGACATTGTG CTTTGGTACA GGGATTCCTG CTATGATTTT CTCCCAATAA AAGCTTCAGA TGGAAAGACC TATGACGCAT ATATACTGTA TCCAAAGACT GTTGGGGAAG GGTCTACCTC TGACTGTGAT ATTTTTGTGT TTAAAGTCTT GCCTGAGGTC TTGGAAAAAC AGTGTGGATA TAAGCTGTTC ATTTATGGAA GGGATGACTA CGTTGGGGAA GACATTGTTG AGGTCATTAA TGAAAACGTA AAGAAAAGCA GAAGACTGAT TATCATTTTA GTCAGAGAAA CATCAGGCTT CAGCTGGCTG GGTGGTTCAT CTGAAGAGCA AATAGCCATG TATAATGCTC TTGTTCAGGA TGGAATTAAA GTTGTCCTGC TTGAGCTGGA GAAAATCCAA GACTATGAGA AAATGCCAGA ATCGATTAAA TTCATTAAGC AGAAACATGG GGCTATCCGC TGGTCAGGGG ACTTTACACA GGGACCACAG TCTGCAAAGA CAAGGTTCTG GAAGAATGTC AGGTACCACA TGCCAGTCCA GCGACGGTCA CCTTCATCTA AACACCAGTT ACTGTCACCA GCCACTAAGG AGAAACTGCA AAGAGAGGCT CACGTGCCTC TCGGGTAGCA TGGAGAAGTT GCCAAGAGTT CTTTAGGTGC CTCCTGTCTT ATGGCGTTGC AGGCCAGGTT ATGCCTCATG CTGACTTGCA GAGTTCATGG AATGTAACTA TATCATCCTT TATCCCTGAG GTCACCAGGA ATCAGG-3' (FRAG. NO:_)(SEQ. ID NO:2519)

Human Interleukin-8* Fragments Antisense Oligonucleotide Fragments

5'-GBTGTTTGTT BCCBBBGCBT CBBGBBTBGC TTTGCTBTCT BBGGBTCBCB TTTBGBCBTB GGBBBBCGCT GTBGGTCBGBB BGBTGTGCTT BCCTTCBCBC BGBGCTGCBG BBBTCBGGBBGG CTGCCBBGBGBG CCBCGGCCBGC TTGGBGTCBT GTTTBCBCBC BGTGBGGTGC TCCGGTGGCT TTTTGCTTGT GTGCTCTGCT GTCTCTG TTC CTTCCGGTGG TTTCTTCCTG GCTCTTGTCC TTTCTCTTGG CCCTTGGCCC-3' (FRAG. NO:1834) (SEQ. ID NO:1845) 5 -G CTC CGG-3' (FRAG. NO:1835) (SEQ. ID NO:1846) 5 -CBBGBBTBGC-3' (FRAG. NO:1836) (SEQ. ID NO:1847) 5'-CBCBC BGTGBGGTGC-3' (FRAG. NO:1837) (SEQ. ID NO:1848) 5 -BCCBBBGCBT CBBGBBTBGC-3' (FRAG. NO:1838) (SEQ. ID NO:1849) 5'-GCCBBGBGBG CCBCGGCCBGC-3' (FRAG. NO:1839) (SEQ. ID NO:1850) 5'-GTG CTC CGG TGG CTT TTT-3' (FRAG. NO:1289)(SEQ. ID NO:1299) 5'-GCT TGT GTG CTC TGC TGT CTC TG-3' (FRAG. NO:1290)(SEQ. ID NO:1300) 5'-'TTC CTT CCG GTG GTT TCT TCC TGG CTC TTG TCC T-3' (FRAG. NO:1291)(SEQ. ED NO:1301) 5'-TTC TCT TGG CCC TTG GCC C-3' (FRAG. NO:1292)(SEQ. ID NO:1302)

₅'-GBTGTTTGTT BCCBBBGCBT CBBGBBTBGC TTTGCTBTCT BBGGBTCBCB TTTBGBCBTB GGBBBBCGCT GTBGGTCBGBB BGBTGTGCTT BCCTTCBCBC BGBGCTGCBG BBBTCBGGBBGG CTGCCBBGBGBG CCBCGGCCBGC TTGGBGTCBT GTTTBCBCBC BGTGBGGTGC TCCGGTGGCT TTTTGCTTGT-3' (FRAG. NO:1840) (SEQ. ID NO:1851) Human IL-8 Receptor Alpha Antisense Oligonucleotide Fragments

5'-ACAGGGGCTG TAATCTTCATC TGCAGGTGGC ATGCCAGTGA AATTTAGATC ATCAAAATCC CACATCTGTG GATCTGTAAT ATTTGACATG TCCTCTTCAG TTTCAGCAAT GGTTTGATCT AACTGAAGCA CCGGCCAGGB CBGGGGCTGT BBTCTTCBTC TGCBGGTGGC BTGCCBGTGB BBTTTBGBTC BTCBBBBTCC CBCBTCTGTG GBTCTGTBBT BTTTGBCBTG TCCTCTTCBG TTTCBGCBB TGGTTTGBTC TBBCTGBBGC BCCGGCCBGG TGGCTCGGTG CTTCTGCCCC TGTTGTTGCG GCGCTCGGTT GGTGTGGCCC CTGTGGTGCT TCGTTTCCCC CTCTTTCTCT TTGTTCGGGG GTTCTTGTGG CGGGCTGCTT GTCTCGTTCC-3' EPI-109 199

(FRAG. NO:1841) (SEQ. ID NO.1852) 5 -CBGGGGC-3' (FRAG. NO:1842) (SEQ. ID NO:1853) 5 -GCBGGTGGC-3' (FRAG. NO:1843) (SEQ. ID NO:1854) 5 -GCGGCGCTC-3' (FRAG. NO:1844) (SEQ. ID NO:1855) S'-TGGCTCGGTGCTTCTGCCCC (FRAG. NO:1293)(SEQ. ID NO:1303) 5 -TGTTGTTGCGGCGCTC (FRAG. NO:1294)(SEQ. ED NO:1304) 5'-GGTTGGTGTGGCCCCTG (FRAG. NO:1295)(SEQ. ID NO:1305) 5'-TGGTGCTTCGTTTCC (FRAG. NO:1296)(SEQ. ED NO:1306) S'-CCCTCTTTCTCTTTGTTC (FRAG. NO:1297)(SEQ. ED NO:1307) 5'-GGGGGTTCTTGTGGC (FRAG. NO:1298)(SEQ. ID NO:1308) 5'-GGGCTGCTTGTCTCGTTCC (FRAG. NO:1299)(SEQ. ID NO:1309)

5'-ACAGGGGCTG TAATCTTCATC TGCAGGTGGC ATGCCAGTGA AATTTAGATC ATCAAAATCC CACATCTGTG GATCTGTAAT ATTTGACATG TCCTCTTCAG TTTCAGCAAT GGTTTGATCT AACTGAAGCA CCGGCCAGG-3' (FRAG. NO:1845) (SEQ. ID NO:1856)

5'-B CBGGGGCTGT BBTCTTCBTC TGCBGGTGGC BTGCCBGTGB BBTTTBGBTC BTCBBBBTCC CBCBTCTGTG GBTCTGTBBT BTTTGBCBTG TCCTCTTCBG TTTCBGCBB TGGTTTGBTC TBBCTGBBGC BCCGGCCBGG-3' (FRAG. NO:1846) (SEQ. ID NO: 1857)

Interleukin-11 (IL-11) Nucleic Acid and Antisnese Oligonucleotide Fragments

5'-GCTCAGGGCA CATGCCTCCC CTCCCCAGGC CGCGGCCCAG CTGACCCTCG GGGCTCCCCC GGCAGCGGAC AGGGAAGGGT TAAAGGCCCC CGGCTCCCTG CCCCCTGCCC TGGGGAACCC CTGGCCCTGT GGGGACATGA ACTGTGTTTG CCGCCTGGTC CTGGTCGTGC TGAGCCTGTG GCCAGATACA GCTGTCGCCC CTGGGCCACC ACCTGGCCCC CCTCGAGTTT CCCCAGACCC TCGGGCCGAG CTGGACAGCA CCGTGCTCCT GACCCGCTCT CTCCTGGCGG ACACGCGGCA GCTGGCTGCA CAGCTGAGGG ACAAATTCCC AGCTGACGGG GACCACAACC TGGATTCCCT GCCCACCCTG GCCATGAGTG CGGGGGCACT GGGAGCTCTA CAGCTCCCAG GTGTGCTGAC AAGGCTGCGA GCGGACCTAC TGTCCTACCT GCGGCACGTG CAGTGGCTGC GCCGGGCAGG TGGCTCTTCC CTGAAGACCC TGGAGCCCGA GCTGGGCACC CTGCAGGCCC GACTGGACCG GCTGCTGCGC CGGCTGCAGC TCCTGATGTC CCGCCTGGCC CTGCCCCAGC CACCCCCGGA CCCGCCGGCG CCCCCGCTGG CGCCCCCCTC CTCAGCCTGG GGGGGCATCA GGGCCGCCCA CGCCATCCTG GGGGGGCTGC ACCTGACACT TGACTGGGCC GTGAGGGGAC TGCTGCTGCT GAAGACTCGG CTGTGACCCG GGGCCCAAAG CCACCACCGT CCTTCCAAAG CCAGATCTTA TTTATTTATT TATTTCAGTA CTGGGGGCGA AACAGCCAGG TGATCCCCCC GCCATTATCT CCCCCTAGTT AGAGACAGTC CTTCCGTGAG GCCTGGGGGA CATCTGTGCC TTATTTATAC TTATTTATTT CAGGAGCAGG GGTGGGAGGC AGGTGGACTC CTGGGTCCCC GAGGAGGAGG GGACTGGGGT CCCGGATTCT TGGGTCTCCA AGAAGTCTGT CCACAGACTT CTGCCCTGGC TCTTCCCCAT CTAGGCCTGG GCAGGAACAT ATATTATTTA TTTAAGCAAT TACTTTTCAT GTTGGGGTGG GGACGGAGGG GAAAGGGAAG CCTGGGTTTT TGTACAAAAA TGTGAGAAAC CTTTGTGAGA CAGAGAACAG GGAATTAAAT GTGTCATACA TATCC CAGCTGCGGC ATCCTCTGTC TCAGAGTCTT GGTGTCTCTG TTCCTTTCCC CTCGGGGTCT CCCTGGGTCT CCCCAAGTCC CTCCTGCTGT CTTCCTCCCG CTCTCTGATC TCTGACTCCC AGAACCTCTC CCTCTGTCTC CAGGGCTGCC CCTCTGATCC TCTTTGCTTC TCTGGTGTGT CTCTCTGGCT GCCTCCATCT CTGTGGATCT CCGTCTCCCT GTCTCTGTCT CAGTCTGTCC TTCACTCTGT GTGTGTGTGT GTCTCTCTCT CTCTCTCTCC TTCCCTTCCA CTCCCTCTTC CTCCTGCCTC CACCTCTCCA GGCCCCTGTC TTGTCCCTCC GTCCGGCCTT TCTCTGCCTT TCCGTCCTCC TGCCTCCCCA TCTCTCTCTG CTAGTCCTGT CCAGCCGGAC CCCCACCCAC AGTCGGGCCC CAGCGCTTGA GCCTGAGTGT CTGCTCCGGC CCGTGGAGGT GGAGGGAGGG GACGCCAATG ACCTCACCAG CCCCTCTCCG ACCACCCCCC CCTTTCCCTT TTCAACTTTT CCAACTTTTC CTTCCGTGCC CTCCTCCGAG CGCGGCGGCG TGAGCCCTGC AAGGCAGCCG CTCCGTCTGA ATGGAAAAGG CAGGCAGGGA GGGTGAGTCA GGATGTGTCA GGCCGGCCCT CCCCTGCCGC CTGCCCCCCG CCCGCCCGCC CCAGGCCCCC TATATAACCC CCCAGGCGTC CACACTCCCT CACTGCCGCG GGCCCTGCTG CTCAGGGCAC ATGCCTCCCC TCCCCAGCCG CGGGCCCAGC TGACCCTCGG GGCTCCCCCG GCAGCGGACA GGGAAGGGTT AAAGGCCCCC GGCTCCCTGC CCCCTGCCCT GGGGAACCCC TGGCCCTGTG GGGACATGAA CTGTAAGTTG GTTCATGGGG AGGGTGGAGG GGACAGGGAG GCAGGGAGGA GAGGGACCCA CGGCGGGGGT GGGAGCAGAC CCCGCTGAGT CGCACAGAGA GGGACCCGGA GACAGGCAGC CGGGGAGGAG AGCAGCTTCG GAGACAGGAG GCGGCGGAGG AGATGGGCAG AGAGAGACAC AGACAGGAGC GGATGGAGGC AGCCAATCAG AGGCGCCGCA GGAGGGACGG GCCAGACAGG GCCCGAGAGG AGCGAGACGC GAGACCGAGC AGGGGCAGGG ACGCAGGGAC TGGTGCCGGG AGGGAGGTGA CCCCCATCGA CCCAGGCCCC AGGGAGCCCG CGGGGACCGG GAGACTCCCT GGGATTCCGG CAGAGAGGCT CCGGAGGGAA ACTGAGGCAG GGTCCGCGGA GAGCGGAGCA AGCCAGGGAG TAGCGACCCC AGCCGGGGGG AGGAGAGAGA CTGGGCGCCG GGGGAAAGCG GGGAGAGCCG GGCAGATGCG GCCGACGGAG GCGCGGACAG ACCGACGGCT GGCGGGCCCG GGGGGCGGGC TGGGGGTGTG CGAGGCGCGG GCGGCCGGGG AGCGCTGATT GGCTGGCGGG TGGCCGGGTG GGCGGGGCGG CCGGGGTGGG CTGCGGGGAG CGAGCTCCGG ACCCCCGCGC CCCCGGCGCC CCCCGCGCCC CCCGCCGCCA GCTCTCCCGC TCCCGGCGCC CGGCCGGGCC ATGGCTCTGC CCCTCTCCGC CCAGGTGCGC TGCGGCCCGG GCTTCTGCCG CCCACCCGGC GGGCTCCTGG GAGGGCGTCT AAGGGGTCTC CCGTGGGAGA GGTCCGTGTC TCCCGGACTC CGTCCTGGGC TTTTGGCTCC TTCCCCTGCT CCCAGCCAGC TCGGGCTCCC GCGGCCCGGG GAGGGGGCAG GTTCTGGCCT GTGCCTCCCC CACCATCCGC GCCCCGGGGC CCAGATTCCG GCGTCCGGGG GCGGACGGGA GACGCCCGGG CCGCGTCTGC TCCGACGGGC GGGGCAGCCA GAGCCAGGGA GGGAGAGGGA AGCCCGCCTG GCCCTGCGAC CTGCCCGCGG GCGTTCCACC CTGGGACTTA AGACCTCCAG CTCCATCCTC CCTAAGGCCG GGAGTCCAGG CCCCAGACCC TCCTCCCCGA GACCCAGGAG TCCAGACCCC AGGCCTTCCT CCCTCAGACC TAGGAGTCCA GGCCCCCAGC EPI-109 200

CTCTCCTCCC TCAGACCCAG GAGGAGTCCA GACCCCAGTT CCTCCTCCCT CAGACCCGGG AGTCCAGCCC AGGCCCTCCT CTCTCAGACC CGGAGTCCAG CCTGAGCTCT CTGCCTTATC CTGCCCCCAG GTGTTTGCCG CCTGGTCCTG GTCGTGCTGA GCCTGTGGCC AGATACAGCT GTCGCCCCTG GGCCACCACC TGGCCCCCCT CGAGTTTCCC CAGACCCTCG GGCCGAGCTG GACAGCACCG TGCTCCTGAC CCGCTCTCTC CTGGCGGACA CGCGGCAGCT GGCTGCACAG CTGGTAGGAG AGACTGGGCT GGGGCCAGCA CAGGAGTGAG AGGCAGAGAG GAACGGAGAG GAGTCTGCGG GCAGCCACTT GGAGGGGTTC TGGGCTCTCA GGTGGCAGAG TGAGGGAGGG GAAGAGTTGG GGGCCTGGCG TGGGGGATGG AGGGAGCCCC GAGGCTGGGC AGGGGCCACC TCACAGCTTT TTTCCCTGCC AGAGGGACAA ATTCCCAGCT GACGGGGACC ACAACCTGGA TTCCCTGCCC ACCCTGGCCA TGAGTGCAGG GGCACTGGGA GCTCTACAGG TAAGGGCAAG GGAGTGGGCT GGGGACAAGG TGGGAGGCAG GCAGTGAAGG GGGCGGGGAG GATGAGGGGC ACTGGTCGGG TGTTCTCTGA TGTCCCGGCT CTATCCCCAG CTCCCAGGTG TGCTGACAAG GCTGCGAGCG GACCTACTGT CCTACCTGCG GCACGTGCAG TGGCTGCGCC GGGCAGGTGG CTCTTCCCTG AAGACCCTGG AGCCCGAGCT GGGCACCCTG CAGGCCCGAC TGGACCGGCT GCTGCGCCGG CTGCAGCTCC TGGTATGTCC TGGCCCCAAG ACCTGACACC CCAGACCCCC ACCCCTGGCC CCAAAATCCT GTGGCCTCAG TCCTTGAAGC CTGAGACCCC AGACCCGAGT GCAACAGCCC CGCTCTGAGA CCCTGACACC CTAACAGCCC GCTCTGAGAC CCTGACACCG TAACAGCCCC GCTCTGAGAC CCTGACCCTA ACAGTCCTGC TCTGAGACCC TGACCCTGCA GTCCCAAGAT CCTGTGGCCC TGAGACCCTG AGGCCCTAGA CCCCCAAATC CTGCCCAGAA ACTTCAAATT CTCACCCAAG ACCCTGAGAC TCCATCATCC ATGACCTCAA AGTCCCCAGA TCCCAGCCCC TAAGACCCAA GACCCCATCC TGAAGCCCAA AGCCTTGAGA ATTCAAATCC TCACCTCAAG ACTTGGAGAC CCTGGCCCCA TGACATTGAA AACCATGGAC CTGGCCAGGC GTGGTGGCTC ACGCCTGTAA TCCCAGCACT TTGGGAGGCC GAGGCAAGTG GATCACCTGA GGTCGGGAGT TCAAGACCAG CCAGACCAAC ATGGTGAAAC CCTGTCTCTA CTAAAAATAC AAAATTAGCC AGGCGTGGTG GTGCATGCCT GTAATCCCAG CTACTTGGGA GGCTGAGGCA GGAGAATCGC TTGAACCTGG GAGGCGGAGG TTGCAGTGAG CCGAGATCGC ACCATTACAC TCCAGCCTGG GCAACAAGAG CAAAACTCCC TCTCTCTCAA AAAAAAAAAA AAAAAAAAAA AAGAAGGAAA AGAAAACCAT GGACCTCCAG ACCCTGAGAC CCCAGGCCCC AGCCCTGAGA TCCTGACATC TTAAAGATCC CAGGCCCTAA GATACAAGAC CTTGACCCAA AGCCAGCCTT GGGACCCTGG CTGTACAAAC CCAAGACCTC CAGGACCTAG ACCCCGAGCC CTGAGGCCCT ATGTCTCACT CCCAACATCG AAAACCCTGA CACCTCAGAT CCTGAGCCTG CGCCTGTACG ACTCCAAGAC CCTCACTTCC AAAGCCAGGC CCAAAGCCCT GAGACCAGAA GACTTCAAAC CCTGGTTCTT GGGCCTAACT CCAAAGACCC TGGATCTCAA ATTCCAACTT CTAGCTCTGA GACTCCAGCC CTCACCCATG AGTTCCTGAA CTTGAACCCA GAGACCCCAT CTCTAAGACT TCAGCCTTGA GATCCAGGGC CTGACCCTAG ACTCGAGCCC ACAGACCTCA GATACTGTCT GTAAAACCCC AGCTCTGGTG GGGAGCAGTG GCTCACTCCT GTAATCCCAA GGCAGGGGAG GCCAAGGCAG AAGGACCTCT TGAGGCCATG AGTTTGAGAC AGCCTGGGCA GCATAGCAAG ACTCTGTTTC TTAATTATTA TTATTATTAT TATTTTTTGG AGACAGAGTC TCGCGCTCTG TTGCCCAGGC TAGAGTGCAA TGGTGCCATT TCGGCTTGCT GGAACCTCCG CCTCCTGGGC TCAAGCGATT CTCCTGCCTC AGCCTCCTGA GTAGCTGGGA CTTCAGGTGC ACACTGCCAC ACCCGGATAA TTTTTTTGTA TTTTAGTAGA CACAGGGTTT CACCGTGTTG CCCAGGCTGG TCACAAACTC CTGAGCTCAG GCCATCCGCC CGCCTCGGCC TCCCAAAGCG CTGGGATAAC AGGCGTGACG CCGCGCCTGG CTTCTTAATT GTTCTAACAG CAGCGACAAC AACAAAAACC CAGCTCTGAG ATTCCAGCCC CGGCGACTCT AACAGTCCCA GGCCCGATCC CTCACCTAGA ACCGAGATGC CAGCCCTGAC TCCACAGACT TCACCCCCAA CCCCCACACT CAGCTCTGGA AGCCCGTCCT GACTCCAGCC TCCATTTTCG GAACCCCACA GCCTGAAGAG CTCCCGGCCT AAACACTTCA CCCCACGCGC CACAGTCCCC CTGTGAATAT GCAGCCCCGA TTCAGCTGCA GCTCCACAGC ACCCCTGCCC TGCACCCCCG CTGCACCCCC TACCTGTGAC TCACCTCTCT CCTCTCCCCA CAGATGTCCC GCCTGGCCCT GCCCCAGCCA CCCCCGGACC CGCCGGCGCC CCCGCTGGCG CCCCCCTCCT CAGCCTGGGG GGGCATCAGG GCCGCCCACG CCATCCTGGG GGGGCTGCAC CTGACACTTG ACTGGGCCGT GAGGGGACTG CTGCTGCTGA AGACTCGGCT GTGACCCGGG GCCCAAAGCC ACCACCGTCC TTCCAAAGCC AGATCTTATT TATTTATTTA TTTCAGTACT GGGGGCGAAA CAGCCAGGTG ATCCCCCCGC CATTATCTCC CCCTAGTTAG AGACAGTCCT TCCGTGAGGC CTGGGGGGCA TCTGTGCCTT ATTTATACTT ATTTATTTCA GGAGCAGGGG TGGGAGGCAG GTGGACTCCT GGGTCCCCGA GGAGGAGGGG ACTGGGGTCC CGGATTCTTG GGTCTCCAAG AAGTCTGTCC ACAGACTTCT GCCCTGGCTC TTCCCCATCT AGGCCTGGGC AGGAACATAT ATTATTTATT TAAGCAATTA CTTTTCATGT TGGGGTGGGG ACGGAGGGGA AAGGGAAGCC TGGGTTTTTG TACAAAAATG TGAGAAACCT TTGTGAGACA GAGAACAGGG AATTAAATGT GTCATACATA TCCACTTGAG GGCGATTTGT CTGAGAGCTG GGGCTGGATG CTTGGGTAAC TGGGGCAGGG CAGGTGGAGG GGAGACCTCC ATTCAGGTGG AGGTCCCGAG TGGGCGGGGC AGCGACTGGG AGATGGGTCG GTCACCCAGA CAGCTCTGTG GAGGCAGGGT CTGAGCCTTG CCTGGGGCCC CGCACTGCAT AGGGCCGTTT GTTTGTTTTT TGAGATGGAG TCTCGCTCTG TTGCCTAGGC TGGAGTGCAG TGAGGCAATC TAAGGTCACT GCAACCTCCA CCTCCCGGGT TCAAGCAATT CTCCTGCCTC AGCCTCCCGA TTAGCTGGGA TCACAGGTGT GCACCACCAT GCCCAGCTAA TTATTTATTT CTTTTGTATT TTTAGTAGAG ACAGGGTTTC ACCATGTTGG CCAGGCTGGT TTCGAACTCC TGACCTCAGG TGATCCTCCT GCCTCGGCCT CCCAAAGTGC TGGGATTACA GGTGTGAGCC ACCACACCTG ACCCATAGGT CTTCAATAAA TATTTAATGG AAGGTTCCAC AAGTCACCCT GTGATCAACA GTACCCGTAT GGGACAAAGC TGCAAGGTCA AGATGGTTCA TTATGGCTGT GTTCACCATA GCAAACTGGA AACAATCTAG ATATCCAACA GTGAGGGTTA AGCAACATGG TGCATCTGTG GATAGAACGC CACCCAGCCG CCCGGAGCAG GGACTGTCAT TCAGGGAGGC TAAGGAGAGA GGCTTGCTTG GGATATAGAA AGATATCCTG ACATTGGCCA GGCATGGTGG CTCACGCCTG TAATCCTGGC ACTTTGGGAG GACGAAGCGA GTGGATCACT GAAGTCCAAG AGTTTGAGAC CGGCCTGCGA GACATGGCAA AACCCTGTCT CAAAAAAGAA AGAATGATGT CCTGACATGA AACAGCAGGC TACAAAACCA CTGCATGCTG TGATCCCAAT TTTGTGTTTT TCTTTCTATA TATGGATTAA AACAAAAATC CTAAAGGGAA ATACGCCAAA ATGTTGACAA TGACTGTCTC CAGGTCAAAG GAGAGAGGTG GGATTGTGGG TGACTTTTAA TGTGTATGAT TGTCTGTATT TTACAGAATT TCTGCCATGA CTGTGTATTT TGCATGACAC ATTTTAAAAA TAATAAACAC TATTTTTAGA ATAACAGAAT ATCAGCCTCC TCCTCTCCAA EPI-109 201

AAATAAGCCC TCAGGAGGGG ACAAAGTTGA CCGCTGATTG AGCCTGTCAG GGCTGTGCAC-3' (FRAG. NO: (^~SEQ. ID NO:2523)

5'-GCTCAGGGCA CATGCCTCCC CTCCCCAGGC CGCGGCCCAG CTGACCCTCG GGGCTCCCCC GGCAGCGGAC AGGGAAGGGT TAAAGGCCCC CGGCTCCCTG CCCCCTGCCC TGGGGAACCC CTGGCCCTGT GGGGACATGA ACTGTGTTTG CCGCCTGGTC CTGGTCGTGC TGAGCCTGTG GCCAGATACA GCTGTCGCCC CTGGGCCACC ACCTGGCCCC CCTCGAGTTT CCCCAGACCC TCGGGCCGAG CTGGACAGCA CCGTGCTCCT GACCCGCTCT CTCCTGGCGG ACACGCGGCA GCTGGCTGCA CAGCTGAGGG ACAAATTCCC AGCTGACGGG GACCACAACC TGGATTCCCT GCCCACCCTG GCCATGAGTG CGGGGGCACT GGGAGCTCTA CAGCTCCCAG GTGTGCTGAC AAGGCTGCGA GCGGACCTAC TGTCCTACCT GCGGCACGTG CAGTGGCTGC GCCGGGCAGG TGGCTCTTCC CTGAAGACCC TGGAGCCCGA GCTGGGCACC CTGCAGGCCC GACTGGACCG GCTGCTGCGC CGGCTGCAGC TCCTGATGTC CCGCCTGGCC CTGCCCCAGC CACCCCCGGA CCCGCCGGCG CCCCCGCTGG CGCCCCCCTC CTCAGCCTGG GGGGGCATCA GGGCCGCCCA CGCCATCCTG GGGGGGCTGC ACCTGACACT TGACTGGGCC GTGAGGGGAC TGCTGCTGCT GAAGACTCGG CTGTGACCCG GGGCCCAAAG CCACCACCGT CCTTCCAAAG CCAGATCTTA TTTATTTATT TATTTCAGTA CTGGGGGCGA AACAGCCAGG TGATCCCCCC GCCATTATCT CCCCCTAGTT AGAGACAGTC CTTCCGTGAG GCCTGGGGGA CATCTGTGCC TTATTTATAC TTATTTATTT CAGGAGCAGG GGTGGGAGGC AGGTGGACTC CTGGGTCCCC GAGGAGGAGG GGACTGGGGT CCCGGATTCT TGGGTCTCCA AGAAGTCTCT CCACAGACTT CTGCCCTGGC TCTTCCCCAT CTAGGCCTGG GCAGGAACAT ATATTATTTA TTTAAGCAAT TACTTTTCAT GTTGGGGTGG GGACGGAGGG GAAAGGGAAG CCTGGGTTTT TGTACAAAAA TGTGAGAAAC CTTTGTGAGA CAGAGAACAG GGAATTAAAT GTGTCATACA TATCC-3' (FRAG. NO:_)(SEQ. ID NO:2521)

5'-CAGCTGCGGC ATCCTCTGTC TCAGAGTCTT GGTGTCTCTG TTCCTTTCCC CTCGGGGTCT CCCTGGGTCT CCCCAAGTCC CTCCTGCTGT CTTCCTCCCG CTCTCTGATC TCTGACTCCC AGAACCTCTC CCTCTGTCTC CAGGGCTGCC CCTCTGATCC TCTTTGCTTC TCTGGTGTGT CTCTCTGGCT GCCTCCATCT CTGTGGATCT CCGTCTCCCT GTCTCTGTCT CAGTCTGTCC TTCACTCTGT GTGTGTGTGT GTCTCTCTCT CTCTCTCTCC TTCCCTTCCA CTCCCTCTTC CTCCTGCCTC CACCTCTCCA GGCCCCTGTC TTGTCCCTCC GTCCGGCCTT TCTCTGCCTT TCCGTCCTCC TGCCTCCCCA TCTCTCTCTG CTAGTCCTGT CCAGCCGGAC CCCCACCCAC AGTCGGGCCC CAGCGCTTGA GCCTGAGTGT CTGCTCCGGC CCGTGGAGGT GGAGGGAGGG GACGCCAATG ACCTCACCAG CCCCTCTCCG ACCACCCCCC CCTTTCCCTT TTCAACTTTT CCAACTTTTC CTTCCGTGCC CTCCTCCGAG CGCGGCGGCG TGAGCCCTGC AAGGCAGCCG CTCCGTCTGA ATGGAAAAGG CAGGCAGGGA GGGTGAGTCA GGATGTGTCA GGCCGGCCCT CCCCTGCCGC CTGCCCCCCG CCCGCCCGCC CCAGGCCCCC TATATAACCC CCCAGGCGTC CACACTCCCT CACTGCCGCG GGCCCTGCTG CTCAGGGCAC ATGCCTCCCC TCCCCAGCCG CGGGCCCAGC TGACCCTCGG GGCTCCCCCG GCAGCGGACA GGGAAGGGTT AAAGGCCCCC GGCTCCCTGC CCCCTGCCCT GGGGAACCCC TGGCCCTGTG GGGACATGAA CTGTAAGTTG GTTCATGGGG AGGGTGGAGG GGACAGGGAG GCAGGGAGGA GAGGGACCCA CGGCGGGGGT GGGAGCAGAC CCCGCTGAGT CGCACAGAGA GGGACCCGGA GACAGGCAGC CGGGGAGGAG AGCAGCTTCG GAGACAGGAG GCGGCGGAGG AGATGGGCAG AGAGAGACAC AGACAGGAGC GGATGGAGGC AGCCAATCAG AGGCGCCGCA GGAGGGACGG GCCAGACAGG GCCCGAGAGG AGCGAGACGC GAGACCGAGC AGGGGCAGGG ACGCAGGGAC TGGTGCCGGG AGGGAGGTGA CCCCCATCGA CCCAGGCCCC AGGGAGCCCG CGGGGACCGG GAGACTCCCT GGGATTCCGG CAGAGAGGCT CCGGAGGGAA ACTGAGGCAG GGTCCGCGGA GAGCGGAGCA AGCCAGGGAG TAGCGACCCC AGCCGGGGGG AGGAGAGAGA CTGGGCGCCG GGGGAAAGCG GGGAGAGCCG GGCAGATGCG GCCGACGGAG GCGCGGACAG ACCGACGGCT GGCGGGCCCG GGGGGCGGGC TGGGGGTGTG CGAGGCGCGG GCGGCCGGGG AGCGCTGATT GGCTGGCGGG TGGCCGGGTG GGCGGGGCGG CCGGGGTGGG CTGCGGGGAG CGAGCTCCGG ACCCCCGCGC CCCCGGCGCC CCCCGCGCCC CCCGCCGCCA GCTCTCCCGC TCCCGGCGCC CGGCCGGGCC ATGGCTCTGC CCCTCTCCGC CCAGGTGCGC TGCGGCCCGG GCTTCTGCCG CCCACCCGGC GGGCTCCTGG GAGGGCGTCT AAGGGGTCTC CCGTGGGAGA GGTCCGTGTC TCCCGGACTC CGTCCTGGGC TTTTGGCTCC TTCCCCTGCT CCCAGCCAGC TCGGGCTCCC GCGGCCCGGG GAGGGGGCAG GTTCTGGCCT GTGCCTCCCC CACCATCCGC GCCCCGGGGC CCAGATTCCG GCGTCCGGGG GCGGACGGGA GACGCCCGGG CCGCGTCTGC TCCGACGGGC GGGGCAGCCA GAGCCAGGGA GGGAGAGGGA AGCCCGCCTG GCCCTGCGAC CTGCCCGCGG GCGTTCCACC CTGGGACTTA AGACCTCCAG CTCCATCCTC CCTAAGGCCG GGAGTCCAGG CCCCAGACCC TCCTCCCCGA GACCCAGGAG TCCAGACCCC AGGCCTTCCT CCCTCAGACC TAGGAGTCCA GGCCCCCAGC CTCTCCTCCC TCAGACCCAG GAGGAGTCCA GACCCCAGTT CCTCCTCCCT CAGACCCGGG AGTCCAGCCC AGGCCCTCCT CTCTCAGACC CGGAGTCCAG CCTGAGCTCT CTGCCTTATC CTGCCCCCAG GTGTTTGCCG CCTGGTCCTG GTCGTGCTGA GCCTGTGGCC AGATACAGCT GTCGCCCCTG GGCCACCACC TGGCCCCCCT CGAGTTTCCC CAGACCCTCG GGCCGAGCTG GACAGCACCG TGCTCCTGAC CCGCTCTCTC CTGGCGGACA CGCGGCAGCT GGCTGCACAG CTGGTAGGAG AGACTGGGCT GGGGCCAGCA CAGGAGTGAG AGGCAGAGAG GAACGGAGAG GAGTCTGCGG GCAGCCACTT GGAGGGGTTC TGGGCTCTCA GGTGGCAGAG TGAGGGAGGG GAAGAGTTGG GGGCCTGGCG TGGGGGATGG AGGGAGCCCC GAGGCTGGGC AGGGGCCACC TCACAGCTTT TTTCCCTGCC AGAGGGACAA ATTCCCAGCT GACGGGGACC ACAACCTGGA TTCCCTGCCC ACCCTGGCCA TGAGTGCAGG GGCACTGGGA GCTCTACAGG TAAGGGCAAG GGAGTGGGCT GGGGACAAGG TGGGAGGCAG GCAGTGAAGG GGGCGGGGAG GATGAGGGGC ACTGGTCGGG TGTTCTCTCA TGTCCCGGCT CTATCCCCAG CTCCCAGGTG TGCTGACAAG GCTGCGAGCG GACCTACTGT CCTACCTGCG GCACGTGCAG TGGCTGCGCC GGGCAGGTGG CTCTTCCCTG AAGACCCTGG AGCCCGAGCT GGGCACCCTG CAGGCCCGAC TGGACCGGCT GCTGCGCCGG CTGCAGCTCC TGGTATGTCC TGGCCCCAAG ACCTGACACC CCAGACCCCC ACCCCTGGCC CCAAAATCCT GTGGCCTCAG TCCTTGAAGC CTGAGACCCC AGACCCGAGT GCAACAGCCC CGCTCTGAGA CCCTGACACC CTAACAGCCC GCTCTGAGAC CCTGACACCG TAACAGCCCC GCTCTGAGAC CCTGACCCTA ACAGTCCTGC TCTGAGACCC TGACCCTGCA GTCCCAAGAT CCTGTGGCCC TGAGACCCTG AGGCCCTAGA CCCCCAAATC CTGCCCAGAA ACTTCAAATT CTCACCCAAG ACCCTGAGAC TCCATCATCC ATGACCTCAA AGTCCCCAGA TCCCAGCCCC TAAGACCCAA GACCCCATCC TGAAGCCCAA AGCCTTGAGA ATTCAAATCC TCACCTCAAG ACTTGGAGAC CCTGGCCCCA TGACATTGAA AACCATGGAC CTGGCCAGGC GTGGTGGCTC ACGCCTGTAA TCCCAGCACT TTGGGAGGCC GAGGCAAGTG GATCACCTGA GGTCGGGAGT TCAAGACCAG CCAGACCAAC ATGGTGAAAC CCTGTCTCTA CTAAAAATAC AAAATTAGCC AGGCGTGGTG GTGCATGCCT GTAATCCCAG CTACTTGGGA GGCTGAGGCA GGAGAATCGC TTGAACCTGG GAGGCGGAGG TTGCAGTGAG CCGAGATCGC ACCATTACAC TCCAGCCTGG GCAACAAGAG CAAAACTCCC TCTCTCTCAA AAAAAAAAAA AAAAAAAAAA AAGAAGGAAA AGAAAACCAT GGACCTCCAG ACCCTGAGAC CCCAGGCCCC AGCCCTGAGA TCCTGACATC TTAAAGATCC CAGGCCCTAA GATACAAGAC CTTGACCCAA AGCCAGCCTT GGGACCCTGG CTGTACAAAC CCAAGACCTC CAGGACCTAG ACCCCGAGCC CTGAGGCCCT ATGTCTCACT CCCAACATCG AAAACCCTGA EPI-109 202

CACCTCAGAT CCTGAGCCTG CGCCTGTACG ACTCCAAGAC CCTCACTTCC AAAGCCAGGC CCAAAGCCCT GAGACCAGAA GACTTCAAAC CCTGGTTCTT GGGCCTAACT CCAAAGACCC TGGATCTCAA ATTCCAACTT CTAGCTCTGA GACTCCAGCC CTCACCCATG AGTTCCTGAA CTTGAACCCA GAGACCCCAT CTCTAAGACT TCAGCCTTGA GATCCAGGGC CTGACCCTAG ACTCGAGCCC ACAGACCTCA GATACTGTCT GTAAAACCCC AGCTCTGGTG GGGAGCAGTG GCTCACTCCT GTAATCCCAA GGCAGGGGAG GCCAAGGCAG AAGGACCTCT TGAGGCCATG AGTTTGAGAC AGCCTGGGCA GCATAGCAAG ACTCTGTTTC TTAATTATTA TTATTATTAT TATTTTTTGG AGACAGAGTC TCGCGCTCTG TTGCCCAGGC TAGAGTGCAA TGGTGCCATT TCGGCTTGCT GGAACCTCCG CCTCCTGGGC TCAAGCGATT CTCCTGCCTC AGCCTCCTGA GTAGCTGGGA CTTCAGGTGC ACACTGCCAC ACCCGGATAA TTTTTTTGTA TTTTAGTAGA CACAGGGTTT CACCGTGTTG CCCAGGCTGG TCACAAACTC CTGAGCTCAG GCCATCCGCC CGCCTCGGCC TCCCAAAGCG CTGGGATAAC AGGCGTGACG CCGCGCCTGG CTTCTTAATT GTTCTAACAG CAGCGACAAC AACAAAAACC CAGCTCTGAG ATTCCAGCCC CGGCGACTCT AACAGTCCCA GGCCCGATCC CTCACCTAGA ACCGAGATGC CAGCCCTGAC TCCACAGACT TCACCCCCAA CCCCCACACT CAGCTCTGGA AGCCCGTCCT GACTCCAGCC TCCATTTTCG GAACCCCACA GCCTGAAGAG CTCCCGGCCT AAACACTTCA CCCCACGCGC CACAGTCCCC CTGTGAATAT GCAGCCCCGA TTCAGCTGCA GCTCCACAGC ACCCCTGCCC TGCACCCCCG CTGCACCCCC TACCTGTGAC TCACCTCTCT CCTCTCCCCA CAGATGTCCC GCCTGGCCCT GCCCCAGCCA CCCCCGGACC CGCCGGCGCC CCCGCTGGCG CCCCCCTCCT CAGCCTGGGG GGGCATCAGG GCCGCCCACG CCATCCTGGG GGGGCTGCAC CTGACACTTG ACTGGGCCGT GAGGGGACTG CTGCTGCTGA AGACTCGGCT GTGACCCGGG GCCCAAAGCC ACCACCGTCC TTCCAAAGCC AGATCTTATT TATTTATTTA TTTCAGTACT GGGGGCGAAA CAGCCAGGTG ATCCCCCCGC CATTATCTCC CCCTAGTTAG AGACAGTCCT TCCGTGAGGC CTGGGGGGCA TCTGTGCCTT ATTTATACTT ATTTATTTCA GGAGCAGGGG TGGGAGGCAG GTGGACTCCT GGGTCCCCGA GGAGGAGGGG ACTGGGGTCC CGGATTCTTG GGTCTCCAAG AAGTCTGTCC ACAGACTTCT GCCCTGGCTC TTCCCCATCT AGGCCTGGGC AGGAACATAT ATTATTTATT TAAGCAATTA CTTTTCATGT TGGGGTGGGG ACGGAGGGGA AAGGGAAGCC TGGGTTTTTG TACAAAAATG TGAGAAACCT TTGTGAGACA GAGAACAGGG AATTAAATGT GTCATACATA TCCACTTGAG GGCGATTTGT CTGAGAGCTG GGGCTGGATG CTTGGGTAAC TGGGGCAGGG CAGGTGGAGG GGAGACCTCC ATTCAGGTGG AGGTCCCGAG TGGGCGGGGC AGCGACTGGG AGATGGGTCG GTCACCCAGA CAGCTCTGTG GAGGCAGGGT CTGAGCCTTG CCTGGGGCCC CGCACTGCAT AGGGCCGTTT GTTTGTTTTT TGAGATGGAG TCTCGCTCTG TTGCCTAGGC TGGAGTGCAG TGAGGCAATC TAAGGTCACT GCAACCTCCA CCTCCCGGGT TCAAGCAATT CTCCTGCCTC AGCCTCCCGA TTAGCTGGGA TCACAGGTGT GCACCACCAT GCCCAGCTAA TTATTTATTT CTΠTGTATT TTTAGTAGAG ACAGGGTTTC ACCATGTTGG CCAGGCTGGT TTCGAACTCC TGACCTCAGG TGATCCTCCT GCCTCGGCCT CCCAAAGTGC TGGGATTACA GGTGTGAGCC ACCACACCTG ACCCATAGGT CTTCAATAAA TATTTAATGG AAGGTTCCAC AAGTCACCCT GTGATCAACA GTACCCGTAT GGGACAAAGC TGCAAGGTCA AGATGGTTCA TTATGGCTGT GTTCACCATA GCAAACTGGA AACAATCTAG ATATCCAACA GTGAGGGTTA AGCAACATGG TGCATCTGTG GATAGAACGC CACCCAGCCG CCCGGAGCAG GGACTGTCAT TCAGGGAGGC TAAGGAGAGA GGCTTGCTTG GGATATAGAA AGATATCCTG ACATTGGCCA GGCATGGTGG CTCACGCCTG TAATCCTGGC ACTTTGGGAG GACGAAGCGA GTGGATCACT GAAGTCCAAG AGTTTGAGAC CGGCCTGCGA GACATGGCAA AACCCTGTCT CAAAAAAGAA AGAATGATGT CCTGACATGA AACAGCAGGC TACAAAACCA CTGCATGCTG TGATCCCAAT TTTGTGTTTT TCTTTCTATA TATGGATTAA AACAAAAATC CTAAAGGGAA ATACGCCAAA ATGTTGACAA TGACTGTCTC CAGGTCAAAG GAGAGAGGTG GGATTGTGGG TGACTTTTAA TGTGTATGAT TGTCTGTATT TTACAGAATT TCTGCCATGA CTGTGTATTT TGCATGACAC ATTTTAAAAA TAATAAACAC TATTTTTAGA ATAACAGAAT ATCAGCCTCC TCCTCTCCAA AAATAAGCCC TCAGGAGGGG ACAAAGTTGA CCGCTGATTG AGCCTGTCAG GGCTGTGCAC-3 ' ( FRAG . NO : _) (SEQ . ID NO : 2522 )

Human GM-CSF Nucleic Acid and Antisense Oligonucleotide Fragments

5'-CTTGBGCBGG BBGCTCTGGG GCBGGGBGCT GGCBGGGCCC BGGGGGGTGG CTTCCTGCBC TGTCCBGBGT GCBCTGTGCC BCBGCBGCBG CTGCBGGGCC BTCBGCTTCB TGGGGCTCTG GGTGGCBGGT CCBGCCBTGG GTCTGGGTGG GGCTGGGCTG CBGGCTCCGG GCGGTCCBGCCBTGGGTCTG GGGGCTGGG CTGCBGGCTC CGGGCGGGCG GGTGCGGGCT GCGTGCTGGG GGCTGCCCCG CAGGCCCTGC GGTCCBGCCB TGGGTCTGGG GGCTGGGCTG CBGGCTCCGG GCGGGCGGGT GCGGGCTGCG TGCTGGGGGC TGCCCCGCAG GCCCTGC-3' (FRAG. NO:1847) (SEQ. ID NO: 1858) 5 -GBGCBGG BBG-3' (FRAG. NO:1848) (SEQ. ID NO: 1859) 5 -GCCBCBGCBGCBGC-3' (FRAG. NO:1849) (SEQ. ID NO: 1860) 5 -GGG TGC GGG C-3' (FRAG. NO:1850) (SEQ. ID NO: 1861) 5'-GGT CCB GCC BTG GGT CTG GG-3' (FRAG. NO:1300)(SEQ. ID NO:1310) 5'-GGC TGG GCT GCB GGC TCC GG-3' (FRAG. NO:1301)(SEQ. ID NO:1311) 5'-GCG GGC GGG TGC GGG CTG CGT GCT GGG-3' (FRAG. NO:1302)(SEQ. ID NO:1312) 5'-GGC TGC CCC GCA GGC CCT GC-3' (FRAG. NO:1303)(SEQ. ID NO:1313)

5'-CTTGBGCBGG BBGCTCTGGG GCBGGGBGCT GGCBGGGCCC BGGGGGGTGG CTTCCTGCBC TGTCCBGBGT GCBCTGTGCC BCBGCBGCBG CTGCBGGGCC BTCBGCTTCB TGGGGCTCTG GGTGGCBGGT CCBGCCBTGG GTCTGGGTGG GGCTGGGCTG CBGGCTCCGG GC-3' (FRAG. NO:1851) (SEQ. ID NO: 1862) Human Tumor Necrosis Factor " Antisense Oligonucleotide Fragments

5'-GCBCCGCCTG GBGCCCTGGG GCCCCCCTGT CTTCTTGGGG BGCGCCTCCT CGGCCBGCTC CBCGTCCCGG BTCBTGCTTT CBGTGCTCBT GGTGTCCTTT CCBGGGGBGB GBGGGGCTGG TCCTCTGCTG TCCTTGCTGG TGCTCBTGGT GTCCTTTCCG CCCTGGGGCC CCCCTGTCTT CTTGGGGCCT CTTCCCTCTG GGGGCCGTCT CTCTCCCTCT CTTGCGTCTC TCTCTTTCTC TCTCTCTCTT CCCCTTTCCC GCTCTTTCTG TCTCGGTGTC TGGTTTTCTC TCTCCGCTGG CTGCCTGTCT GGCCTGCGCT CTTGGCCTGT GCTGTTCCTC CTCCGGTTCC TGTCCTCTCT GTCTGTCGCC CCCTCTGGGG TCTCCCTCTG GGTGGTGGTC TTGTTGCTTG GGCTGGGCTC CGTGTCTCCB GTGCTCBTGG TGTCCGCTGB GGGBGCGTCT GCTGGCGCTG GTCCTCTGCTGTC CTTGCTGGTG CTCBTGGTGT CCTTTCCGCC CTGGGGCCCC CCTGTCTTCT TGGGGCCTCT TCCCTCTGGG GGCCGTCTC TCTCCCTCTC TTGCGTCTCT CTCTTTCTCT CTCTCTCTTC CCCTTTCCCG CTCTTTCTGT CTCGGTGTCT GGTTTTCTCT CTCCGCTGGC TGCCTGTCTG GCCTGCGCTC TTGGCCTGTG CTGTTCCTCC TCCGGTTCCT GTCCTCTCTG TCTGTCGCCC CCTCTGGGGT CTCCCTCTGG CGTGGTGGTC TTGTTGCTTG GGCTGGGCTC CGTGTCTCCB GTGCTCBTGG TGTCCGCTGB GGGBGCGTCT GCTGGC-3' (FRAG. NO:1852) (SEQ. ID NO:1863) 5'-GGGGCCCCCC-3' (FRAG. NO:1853) (SEQ. ED NO:1864) EPI-109 203

5'- GGG GGC CG TCT-3' (FRAG. NO:1854) (SEQ. ID NO:1865)

5 -CCBGGGGBGB GBGGGGCTGG-3' (FRAG. NO:1855) (SEQ. ID NO:1866)

5'-

GCBCCGCCTGGBGCCCTGGGGCCCCCCTGTCTTCTTGGGGBGCGCCTCCTCGGCCBGCTCCBCGTCCCGGBTCBTGCTTTCBGTGC

TCBTGGTGTCCTTTCCBGGGGBGBGBGGG-3' (FRAG. NO:1304) (SEQ. ID NO:1314)

5 ' GCT GGT CCT CTG CTG TCC TTG CTG GTG CTC BTG GTG TCC TTT CC GCC CTG GGG CCC CCC TGT CTT CTT GGG G

CCT CTT CCC TCT GGG GGC CG TCT CTC TCC CTC TCT TGC GTC TCT C TCT TTC TCT CTC TCT CTT CCC C TTT CCC GCT

CTT TCT GTC TC GGT GTC TGG TTT TCT CTC TCC GCT GGC TGC CTG TCT GGC CTG CGC TCT T GGC CTG TGC TGT TCC

TCC TCC GGT TCC TGT CCT CTC TGT CTG TC GCC CCC TCT GGG GTC TCC CTC TGG C GTG GTG GTC TTG TTG CTT GGG

CTG GGC TCC GTG TCT C CBG TGC TCB TGG TGT CC-3' (FRAG. NO:1305) (SEQ. ID NO:1315)

5'-GCT GBG GGB GCG TCT GCT GGC GCT GGT CCT CTG CTG TCC TTG CTG GTG CTC BTG GTG TCC TTT CC GCC CTG

GGG CCC CCC TGT CTT CTT GGG G CCT CTT CCC TCT GGG GGC CG TCT CTC TCC CTC TCT TGC GTC TCT C TCT TTC

TCT CTC TCT CTT CCC C TTT CCC GCT CTT TCT GTC TC GGT GTC TGG TTT TCT CTC TCC GCT GGC TGC CTG TCT GGC

CTG CGC TCT T GGC CTG TGC TGT TCC TCC TCC GGT TCC TGT CCT CTC TGT CTG TC GCC CCC TCT GGG GTC TCC CTC

TGG C GTG GTG GTC TTG TTG CTT GGG CTG GGC TCC GTG TCT C CBG TGC TCB TGG TGT CC GCT GBG GGB GCG TCT

GCT GGC-3'

(FRAG. NO:1306) (SEQ. ID NO:1316)

5'-GCT GGT CCT CTG CTG TCC TTG CTG-3' (FRAG. NO:1655) (SEQ. ID NO:1665)

5'-GTG CTC BTG GTG TCC TTT CC-3' (FRAG. NO:1656)(SEQ. ID NO:1666)

5'-GCC CTG GGG CCC CCC TGT CTT CTT GGG G-3' (FRAG. NO:1657)(SEQ. ID NO:1667)

5'-CCT CTT CCC TCT GGG GGC CG-3' (FRAG. NO:1658)(SEQ. ID NO:1668)

5'-TCT CTC TCC CTC TCT TGC GTC TCT C-3' (FRAG. NO:1659)(SEQ. ED NO:1669)

5'-TCT TTC TCT CTC TCT CTT CCC C-3' (FRAG. NO:1660)(SEQ. ID NO:1670)

5'-TTT CCC GCT CTT TCT GTC TC-3' (FRAG. NO:1661)(SEQ. ID NO:1671)

5'-GGT GTC TGG TTT TCT CTC TCC-3' (FRAG. NO:1662)(SEQ. ID NO:1672)

5' GCT GGC TGC CTG TCT GGC CTG CGC TCT T-3' (FRAG. NO:1663)(SEQ. ID NO:1673)

5'-GGC CTG TGC TGT TCC TCC-3' (FRAG. NO:1664)(SEQ. ID NO:1673)

5'-TCC GGT TCC TGT CCT CTC TGT CTG TC-3' (FRAG. NO:1665)(SEQ. ID NO:1675)

5'-GCC CCC TCT GGG GTC TCC CTC TGG C-3' (FRAG. NO:1666)(SEQ. ID NO:1676)

5'-GTG GTG GTC TTG TTG CTT-3' (FRAG. NO:1667)(SEQ. ID NO:1677)

5'-GGG CTG GGC TCC GTG TCT C-3' (FRAG. NO:1668)(SEQ. ID NO:1678)

5' CBG TGC TCB TGG TGT CC-3' (FRAG. NO:1669)(SEQ. ID NO:1679)

5' GCT GBG GGB GCG TCT GCT GGC-3' (FRAG. NO:1670)(SEQ. ID NO:1680)

Human Leukotriene C4 Svnthase Nucleic Acids and Antisense Oligonucleotide Fragments

5'-CTCGGTBGBC GCGCTCGBBC TCGGGTGGGC CGGTGGTGBG CGGCGGCGBCB CGCGGBBGGC CCTGCGCGCC

GBGBTCBCCTG CBGGGBGBBG TBGGCTTGCB GCBGGBCTCC CBGGBGGGTG BCBGCBGCCB GTBGBGCTBC CTCGTCCTTC

BTGGTBCCGT CGGTGTGGTG GCBCGGGCTG TGTGTGBBGG CGBGCTGGGC CCCGTCTGCT GCTCCTCGTG CCGCCTCGTC

CTTCA TGG TA CCGTCGGTGT GGTGGCCTCG GGTGGGCCGG TGGTGGGGCG CGCGCGCTCG CGTGGCTCCG GCTCTTCTTT

CCCGGCTCCGT CGGCCCGGGG GCCTTGGTCT CCCTCGTCCT TCBTGGTBCC G-3' (FRAG. NO:1856) (SEQ ID NO: 1867)

5 -GCB GCBGGBC-3' (FRAG. NO:1857) (SEQ ID NO: 1868)

5 -CCCGGCTCCG-3' (FRAG. NO:1858) (SEQ ID NO: 1869)

5 -CGGCCCGGGG GCC-3' (FRAG. NO:1859) (SEQ ID NO: 1870)

5 -CB CGCGG-3' (FRAG. NO:1860) (SEQ ID NO: 1871)

5'-GCC CCG TCT GCT GCT CCT CGT GCC G-3' (FRAG. NO:1307)(SEQ. ID NO:1317)

5'-CCT CGT CCT TCA TGG TAC CGT CGG TGT GGT GGC-3' (FRAG. NO:1308)(SEQ. ID NO:1318)

5 -CTC GGG TGG GCC GGT GGT G-3' (FRAG. NO:1309)(SEQ. ID NO:1319)

5'-GGG CGC GCG CGC TCG CGT-3' (FRAG. NO:1310)(SEQ. ID NO:1320)

5'-GGC TCC GGC TCT TCT TTC CCG GCT CCG TCG GCC CGG GGG CCT TGG TCT C-3' (FRAG. NO:1311) (SEQ. ID NO:1321)

S'-CCT CGT CCT TCB TGG TBC CG-3' (FRAG. NO:1312)(SEQ. ID NO:1322)

5'-CTCGGTBGBC GCGCTCGBBC TCGGGTGGGC CGGTGGTGBG CGGCGGCGBCB CGCGGBBGGC CCTGCGCGCC

GBGBTCBCCTG CBGGGBGBBG TBGGCTTGCB GCBGGBCTCC CBGGBGGGTG BCBGCBGCCB GTBGBGCTBC CTCGTCCTTC

BTGGTBCCGT CGGTGTGGTG GCBCGGGCTG TGTGTGBBGG CGBGCTGG-3' (FRAG. NO:1861) (SEQ ID NO: 1872)

Human Endothelin-1 Nucleic Acids and Antisense Oligonucleotide Fragments

5'-BCCGGCGGBG CCGCCBGGGT GGBCTGGGBG TGGGTTTCTC CCCGCCGTTC TCBCCCBCCG CGCTGBGCTC BGCGCCTBBG

BCTGCTGTTT CTGGBGCTCC TTGGCBBGCC BCBBBCBGCB GBGBGBBBBT CBTGBGCBBB TBBTCCBTTC TGBBBBBBBG

GGBTCBBBBB CCTCCCGTTC CCCGTTCGCC TGGCGCGCGC TGCGGGTTCC TCGTGGGTTT CTCCCCGCCG TTCTCCGGTC

TGTTGCCTTT GTGGGCTTCT TGTCTTTTTG GCTGTTCTTT TCCTGCTTGG CGTCTTTTCC TTTCTTTGTG CTCGGTTGTG

GGTCCGCTGG TCCTTTGCCC TGTGTGTTTC TGCTGCCCGT TCGCCTGGCG CGCGCTGCGG GTTCCTCGTG GGTTTCTCCC

CGCCGTTCTC CGGTCTGTTG CCTTTGTGGG CTTCTTGTCT TTTTGGCTGT TCTTTTCCTG CTTGGCGTCT TTTCCTTTCT

TTGTGCTCGG TTGTGGGTCC GCTGGTCCTT TGCCCTGTGT GTTTCTGCTG-3' (FRAG. NO:1862) (SEQ. ID NO:1873)

5 -CCGGCGGBG CCGCCBGGGT GGBC-3' (FRAG. NO:1863) (SEQ. ID NO:1874)

5 -CCGCCBGGG-3' (FRAG. NO:1864) (SEQ. ID NO:1875)

5 -GGCGCGCGC-3' (FRAG. NO:1865) (SEQ. ID NO:1876)

5 -GTGGGTCCGC-3' (FRAG. NO:1866) (SEQ. ID NO:1877)

5 -CCCGTTCGCCTGGCGC-3' (FRAG. NO:1313)(SEQ. ID NO:1323)

5'-GCGCTGCGGGTTCCTC-3' (FRAG. NO:1314)(SEQ. ID NO:1324)

5'-GTGGGTTTCTCCCCGCCGTTCTC-3' (FRAG. NO:1315)(SEQ. ID NO:1325)

5'-CGGTCTGTTGCCTTTGTGGG -3' (FRAG. NO:1316)(SEQ. ID NO:1326) EPI-109 204

₅'-CTTCTTGTCTTTTTGGCT-3' (FRAG. NO:1317)(SEQ. ID NO:1327) 5'-GTTCTTTTCCTGCTTGGC-3' (FRAG. NO:1318)(SEQ. ID NO:1328) 5 ' -GTCTTTrCCrr rCIT-3 ^* (FRAG. N0:1319)(SEQ. ID NO:1329) 5'-TGTGCTCGGTTGTGGGTC-3' (FRAG. NO:1320)(SEQ. ED NO:1330) 5'-CGCTGGTCCTTTGCC-3' (FRAG. NO:1321)(SEQ. ID NO:1331) 5'-CTGTGTGTTTCTGCTG-3' (FRAG. NO:1322)(SEQ. ID NO:1332) 5'-CCCGTTCGCCTGGCGC-3' (FRAG. NO:1323)(SEQ. ID NO:1333) ₅'-GCGCTGCGGGTTCCTC-3' (FRAG. NO:1324)(SEQ. ED NO:1334) 5'-GTGGGTTTCTCCCCGCCGTTCTC-3' (FRAG. NO:1325(SEQ. ED NO:1335) 5'-CGGTCTGTTGCCTTTGTGGG-3' (FRAG. NO:1326)(SEQ. π) NO:1336) 5'-CTTCTTGTCTTTTTGGCT-3' (FRAG. NO:1327)(SEQ. ID NO:1337) 5'-GTTCTTTTCCTGCTTGGC-3' (FRAG. NO:1328)(SEQ. ID NO:1338) 5'-GTCTTTTCCTTTCTT-3' (FRAG. NO:1329)(SEQ. ID NO:1339) 5'-TGTGCTCGGTTGTGGGTC-3' (FRAG. NO:1330)(SEQ. ID NO:1340) 5 -CGCTGGTCCTTTGCC-3' (FRAG. NO:1331)(SEQ. ID NO:1341) 5'-CTGTGTGTTTCTGCTG-3' (FRAG. NO:1332)(SEQ. ID NO:1342)

Endothelin Receptor ET-B Nucleic Acids and Antisense Oligonucleotide Fragments

5'-GCCCTGTCGG GCGGGAAGCC TCTCTCCTCT CCCCAGATC CGCGACAGGC CGCAGGCAAG AACCAGCGCA ACCAGGGCGC GTCCGCACAG ACTTGGAGGC GGCTGCATGC TGCTACCTGC TCCAGAAGCG TCCGGTGGCC GCCGCGCC CTGTCGGGCG GGBBGCCTCT CTCCTCTCCC CBGBTCCGCG BCBGGCCGCB GGCBBGBBCC BGCGCBBCCB GGGCGCGTCC GCBCBGBCTT GGBGGCGGCT GCBTGCTGCT BCCTGCTCGGGCG GGBBGCCTCCG GTGGCCGCCG CGCGTCCGGT GGCCGCCGCG CCTCTCTCCT CTCCCCGTGG CCCTGTCGGG CGGGTCCTGC CGTCCTGTCT CCTTTTCTTT TGCTGTCTTG TCTTCCCGTC TCTGCTTT-3' (FRAG. NO: 1867) (SEQ. ID NO: 1878) 5 -CGGGCG GGBBGCC-3' (FRAG. NO: 1868) (SEQ. ID NO: 1879) 5 -CGGGCGGG-3' (FRAG. NO: 1869) (SEQ. ID NO: 1880) 5 -CCGCBCBGBC-3' (FRAG. NO: 1870) (SEQ. ID NO: 1881) 5 -GCGTCCGGTGGCCGCCGC-3' (FRAG. NO:1333)(SEQ. ID NO:1343) 5'-GCCTCTCTCCTCTCCCC-3' (FRAG. NO:1334)(SEQ. ID NO:1344) 5'-GTGGCCCTGTCGGGCGGG-3' (FRAG. NO:1335)(SEQ. ED NO:1345) 5'-TCCTGCCGTCCTGTCTCCTTT-3' (FRAG. NO:1336)(SEQ. ID NO:1346) 5 ' -TCπTTGCTGTCTTGT-3 ' (FRAG. NO:1337)(SEQ. ID NO:1347) 5'-CTTCCCGTCTCTGCTTT-3' (FRAG. NO:1338)(SEQ. ID NO.-1348)

5'-GCCCTGTCGG GCGGGAAGCC TCTCTCCTCT CCCCAGATC CGCGACAGGC CGCAGGCAAG AACCAGCGCA ACCAGGGCGC GTCCGCACAG ACTTGGAGGC GGCTGCATGC TGCTACCTGC TCCAGAAGCG TCCGGTGGCC GCCGC-3' (FRAG. NO: 1871) (SEQ. ID NO: 1882)

5' GCCCTGTCGG GCGGGBBGCC TCTCTCCTCT CCCCBGBTCC GCGBCBGGCC GCBGGCBBGB BCCBGCGCB BCCBGGGCGC GTCCGCBCBG BCTTGGBGGC GGCTGCBTGC TGCTBCCTGC TCCBGBBGCG TCCGGTGGCC GCCGC-3' (FRAG. NO: 1872) (SEQ. ID NO: 1883)

Endothelin ETA Receptor Nucleic Acids and Antisense Oligonucleotide Fragments

5'-GTCTGTCCTC CCCGTCTCCT CCCACTGCTT CTCCCGGGGG CTTCCCCGGC TTCGGGTGGC CGGTGTCCCG GGCTCCGGCG CGGCGGCGGC TTCGGCTGCG GGTGGGTGGC GCGGGCTGCC GGGTCCGCGC GGCGCCTGGG CCCTTGTGCT GCTTTTTGCT TGTTCCGTTC TGGCTGCTCC GGTCTGTGTT GTGGTTGTTT TGTTTCTTCT TGGGTGTGGG CCTTGCGGTT TTGGCTGTGG GCCCTTTGGG GCCTTCGCTT CTGGCTCGTC TGTCCTCCCC GTCTCCTCCC ACTGCTTCT CCCGGGGGCT TCCCCGGCTT CGGGTGGCCG GTGTCCCGGG CTCCGGCGCG GCGGCGGCTT CGGCTGCGGG TGGGTGGCGC GGGCTGCCGG GTCCGCGCGG CGCCTCGGCC CTTGTGCTGC TTTTTGCTTG TTCCGTTCTG GCTGCTCCGG TCTGTGTTGT GGTTGTTTTG TTTCTTCTTG GGTGTGGGCC TTGCGGTTTT GGCTGTGGGC CCTTTGGGGC CTTGGCTTCT GGCTCCAT CCACATGATT GCTTAGATTT GTGCTGTATC TCTCAGGATT ATCACTGATT ACACATCCAA CCAGTGCCAG CCAAAAGGAT GCCCTGAGGC AAAGGGTTTC CATCTTGAGG CAAATTTGAG GACBTCCBC BTGBTTGCTT BGBTTTGTGC TGTBTCTCTC BGGBTTBTCB CTGBTTBCBC BTCCBBCCBG TGCCBGCCBB BBGGBTGCCC TGBGGCBBBG GGTTTCCBTC TTGBGGCBBB TTTGBGGB-3' (FRAG. NO:1873) (SEQ. ID NO: 1884)

5 -GBGGCBBBGGG-3' (FRAG. NO:1874) (SEQ. ID NO: 1885) 5'-GCCBGCCBB BBGGB-3' (FRAG. NO:1875) (SEQ. ED NO: 1886) 5'-CGCCTGGGCC C-3' (FRAG. NO:1876) (SEQ. ED NO: 1887) S'-GTCΓGTCCTCCCCGTCTCCTCCC-S' (FRAG. NO:1339)(SEQ. ID NO:1349) 5'-ACTGCTTCTCCCGGGG-3' (FRAG. NO:1340)(SEQ. ID NO:1350) 5'-GCTTCCCCGGCTTC-3' (FRAG. NO:1341)(SEQ. ID NO:1351)

5 -GGGTGGCCGGTGTCCCGGGCTCCGGCGCGGCGGC-3' (FRAG. NO:1342)(SEQ. ED NO:1352) 5'-GGCTTCGGCTGC-3' (FRAG. NO:1343)(SEQ. ID NO:1353) 5 -GGGTGGGTGGCGCGG-3' (FRAG. NO:1344)(SEQ. ED NO:1354) 5'-GCTGCCGGGTCCGCGCGGCGCCTGGGCC-3' (FRAG. NO:1345)(SEQ. ID NO:1355) 5 " -CTTGTGCTGCTπT-3 ' (FRAG. NO:1346(SEQ. ID NO:1356) S'-TGCTTGTTCCGTTC-S' (FRAG. NO:1347)(SEQ. ED NO:1357)

5^•-TGGCTGCTCCGGTCTGTGTTGTGGTTGTTTTG-3^, (FRAG. NO:1348)(SEQ. ED NO:1358) 5'-TTTCTTCTTGGOTGTGGG-3' (FRAG. NO:1349)(SEQ. ED NO:1359) S'-CCTTGCGGTTTTGG-S' (FRAG. NO:1350)(SEQ. ED NO:1360) 5'-CTGTGGGCCCTTTG-3' (FRAG. NO:1351)(SEQ. ID NO:1361) 5'-GGGCCTTGGCTTCTGGCTC-3' (FRAG. NO:1352)(SEQ. ID NO:1362)

5'-CATCCACATG ATTGCTTAGA TTTGTGCTGT ATCTCTCAGG ATTATCACTG ATTACACATC CAACCAGTGC CAGCCAAAAG GATGCCCTGA GGCAAAGGGT TTCCATCTTG AGGCAAATTT GAGGA-3' (FRAG. NO:1353)(SEQ. ID NO:1363) EPI-109 205

5'-CBTCCBCBTG BTTGCTTBGB TTTGTGCTGT BTCTCTCBGG BTTBTCBCTG BTTBCBCBTC CBBCCBGTGC CBGCCBBBBG GBTGCCCTGB GGCBBBGGGT TTCCBTCTTG BGGCBBBTTT GBGGB-3' (FRAG. NO:1354)(SEQ. ID NO:1364) Endothelin Receptor A Nucleic Acid and Antisense Oligonucleotide Fragments

5'-GCCACCATGG AAACCCTTTG CCTCAGGGCA TCCTTTTGGC TGGCACTGGT TGGATGTGTA ATCAGTGATA ATCCTGAGAG ATACAGCACA AATCTAAGCA ATCATGTGGA TGATTTCACC ACTTTTCGTG GCACAGAGCT CAGCTTCCTG GTTACCACTC ATCAACCCAC TAATTTGGTC CTACCCAGCA ATGGCTCAAT GCACAACTAT TGCCCACAGC AGACTAAAAT TACTTCAGCT TTCAAATACA TTAACACTGT GATATCTTGT ACTATTTTCA TCGTGGGAAT GGTGGGGAAT GCAACTCTGC TCAGGATCAT TTACCAGAAC AAATGTATGA GGAATGGCCC CAACGCGCTG ATAGCCAGTC TTGCCCTTGG AGACCTTATC TATGTGGTCA TTGATCTCCC TATCAATGTA TGGCTGGGCG CTGGCCTTTT GATCACAATG ACTTTGGCGT ATTTCTTTGC AAGCTGTTCC CCTTTTTGCA GAAGTCCTCG GTGGGGATCA CCGTCCTCAA CCTCTGCGCT CTTAGTGTTG ACAGGTACAG AGCAGTTGCC TCCTGGAGTC GTGTTCAGGG AATTGGGATT CCTTTGGTAA CTGCCATTGA AATTGCCTCC ATCTGGATCC TGTCCTTTAT CCTGGCCATT CCTGAAGCGA TTGGCTTCGT CATGGTACCC TTTGAATATA GGGGTGGACA GCATAAAACC TGTATGCTCA ATGCCACATC AAAATTCATG GAGTTCTACC AAGATGTAAA GGACTGGTGG CTCTTCGGGT TCTATTTCTG TATGCCCTTG GTGTGCACTG CGATCTTCTA CACCCTCATG ACTGGTGAGA TGTTGAACAG AAGGAATGGC AGCTTGAGAA TTGCCCTCAG TGAACATCTT AAGCAGCGTC GAGAAGTGGC AAAAACAGTT TTCTGCTTGG TTGTAATTTT TGCTCTTTGC TGGTTCCCTC TTCATTTAAG CCGTATATTG AAGAAAACTG TGTATAACGA GATGGACAAG AACCGATGTG AATTACTTAG TTTCTTACTG CTCATGGATT ACATCGGTAT TAACTTGGCA ACCATGAATT CATGTATAAA CCCCATAGCT CTGTATTTTG TGAGCAAGAA ATTTAAAAAT TGTTTCCAGT CATGCCTCTG CTGCTGCTGT TACCAGTCCA AAAGTCTGAT GACCTCGGTC CCCATGAACG GAACAAGCAT CCAGTGGAAG AACCACGATC AAAACAACCA CAACACAGAC CGGAGCAGCC ATAAGGACAG CATGAACTGA CCACCCTTAG AAGCACTCCT GAATTCGGGA AAAAGTGAAG GTGTAAAAGC AGCACAAGTG CAATAAGAGA TATTTCCTCA AATTTGCCTC AAGATGGAAA CCCTTTGCCT CAGGGCATCC TTTTGGCTGG CACTGGTTGG ATGTGTAATC AGTGATAATC CTGAGAGATA CAGCACAAAT CTAAGCAATC ATGTGGATGA TTTCACCACT TTTCGTGGCA CAGAGCTCAG CTTCCTGGTT ACCACTCATC AACCCACTAA TTTGGTCCTA CCCAGCAATG GCTCAATGCA CAACTATTGC CCACAGCAGA CTAAAATTAC TTCAGCTTTC AAATACATTA ACACTGTGAT ATCTTGTACT ATTTTCATCG TGGGAATGGT GGGGAATGCA ACTCTGCTCA GGATCATTTA CCAGAACAAA TGTATGAGGA ATGGCCCCAA CGCGCTGATA GCCAGTCTTG CCCTTGGAGA CCTTATCTAT GTGGTCATTG ATCTCCCTAT CAATGTATTT AAGCTGCTGG CTGGGCGCTG GCCTTTTGAT CACAATGACT TTGGCGTATT TCTTTGCAAG CTGTTCCCCT TTTTGCAGAA GTCCTCGGTG GGGATCACCG TCCTCAACCT CTGCGCTCTT AGTGTTGACA GGTACAGAGC AGTTGCCTCC TGGAGTCGTG TTCAGGGAAT TGGGATTCCT TTGGTAACTG CCATTGAAAT TGTCTCCATC TGGATCCTGT CCTTTATCCT GGCCATTCCT GAAGCGATTG GCTTCGTCAT GGTACCCTTT GAATATAGGG GTGAACAGCA TAAAACCTGT ATGCTCAATG CCACATCAAA ATTCATGGAG TTCTACCAAG ATGTAAAGGA CTGGTGGCTC TTCGGGTTCT ATTTCTGTAT GCCCTTGGTG TGCACTGCGA TCTTCTACAC CCTCATGACT TGTGAGATGT TGAACAGAAG GAATGGCAGC TTGAGAATTG CCCTCAGTGA ACATCTTAAG CAGCGTCGAG AAGTGGCAAA AACAGTTTTC TGCTTGGTTG TAATTTTTGC TCTTTGCTGG TTCCCTCTTC ATTTAAGCCG TATATTGAAG AAAACTGTGT ATAACGAGAT GGACAAGAAC CGATGTGAAT TACTTAGTTT CTTACTGCTC ATGGATTACA TCGGTATTAA CTTGGCAACC ATGAATTCAT GTATAAACCC CATAGCTCTG TATTTTGTGA GCAAGAAATT TAAAAATTGT TTCCAGTCAT GCCTCTGCTG CTGCTGTTAC CAGTCCAAAA GTCTGATGAC CTCGGTCCCC ATGAACGGAA CAAGCATCCA GTGGAAGAAC CACGATCAAA ACAACCACAA CACAGACCGG AGCAGCCATA AGGACAGCAT GAACTGACCA CCCTTAGAAG CACTCCTCGG TACTCCCATA ATCCTCTCGG AGAAAAAAAT CACAAGGCAA CTGTGAGTCC GGGAATCTCT TCTCTGATCC TTCTTCCTTA ATTCACTCCC ACACCCAAGA AGAAATGCTT TCCAAAACCG CAAGGGTAGA CTGGTTTATC CACCCACAAC ATCTACGAAT CGTACTTCTT TAATTGATCT AATTTACATA TTCTGCGTGT TGTATTCAGC ACTAAAAAAT GGTGGGAGCT GGGGGAGAAT GAAGACTGTT AAATGAAACC AGAAGGATAT TTACTACTTT TGCATGAAAA TAGAGCTTTC AAGTACATGG CTAGCTTTTA TGGCAGTTCT GGTGAATGTT CAATGGGAAC TGGTCACCAT GAAACTTTAG AGATTAACGA CAAGATTTTC TACTTTTTTT AAGTGATTTT TTTGTCCTTC AGCCAAACAC AATATGGGCT CAAGTCACTT TTATTTGAAA TGTCATTTGG TGCCAGTATC CCGAATTC GAATTCGGGA AAAAGTGAAG GTGTAAAAGC AGCACAAGTG CAATAAGAGA TATTTCCTCA AATTTGCCTC AAGATGGAAA CCCTTTGCCT CAGGGCATCC TTTTGGCTGG CACTGGTTGG ATGTGTAATC AGTGATAATC CTGAGAGATA CAGCACAAAT CTAAGCAATC ATGTGGATGA TTTCACCACT TTTCGTGGCA CAGAGCTCAG CTTCCTGGTT ACCACTCATC AACCCACTAA TTTGGTCCTA CCCAGCAATG GCTCAATGCA CAACTATTGC CCACAGCAGA CTAAAATTAC TTCAGCTTTC AAATACATTA ACACTGTGAT ATCTTGTACT ATTTTCATCG TGGGAATGGT GGGGAATGCA ACTCTGCTCA GGATCATTTA CCAGAACAAA TGTATGAGGA ATGGCCCCAA CGCGCTGATA GCCAGTCTTG CCCTTGGAGA CCTTATCTAT GTGGTCATTG ATCTCCCTAT CAATGTATTT AAGCTGCTGG CTGGGCGCTG GCCTTTTGAT CACAATGACT TTGGCGTATT TCTTTGCAAG CTGTTCCCCT TTTTGCAGAA GTCCTCGGTG GGGATCACCG TCCTCAACCT CTGCGCTCTT AGTGTTGACA GGTACAGAGC AGTTGCCTCC TGGAGTCGTG TTCAGGGAAT TGGGATTCCT TTGGTAACTG CCATTGAAAT TGTCTCCATC TGGATCCTGT CCTTTATCCT GGCCATTCCT GAAGCGATTG GCTTCGTCAT GGTACCCTTT GAATATAGGG GTGAACAGCA TAAAACCTGT ATGCTCAATG CCACATCAAA ATTCATGGAG TTCTACCAAG ATGTAAAGGA CTGGTGGCTC TTCGGGTTCT ATTTCTGTAT GCCCTTGGTG TGCACTGCGA TCTTCTACAC CCTCATGACT TGTGAGATGT TGAACAGAAG GAATGGCAGC TTGAGAATTG CCCTCAGTGA ACATCTTAAG CAGCGTCGAG AAGTGGCAAA AACAGTTTTC TGCTTGGTTG TAATTTTTGC TCTTTGCTGG TTCCCTCTTC ATTTAAGCCG TATATTGAAG AAAACTGTGT ATAACGAGAT GGACAAGAAC CGATGTGAAT TACTTAGTTT CTTACTGCTC ATGGATTACA TCGGTATTAA CTTGGCAACC ATGAATTCAT GTATAAACCC CATAGCTCTG TATTTTGTGA GCAAGAAATT TAAAAATTGT TTCCAGTCAT GCCTCTGCTG CTGCTGTTAC CAGTCCAAAA GTCTGATGAC CTCGGTCCCC ATGAACGGAA CAAGCATCCA GTGGAAGAAC CACGATCAAA ACAACCACAA CACAGACCGG AGCAGCCATA AGGACAGCAT GAACTGACCA CCCTTAGAAG CACTCCTCGG TACTCCCATA ATCCTCTCGG AGAAAAAAAT CACAAGGCAA CTGTGAGTCC GGGAATCTCT TCTCTGATCC TTCTTCCTTA ATTCACTCCC ACACCCAAGA AGAAATGCTT TCCAAAACCG CAAGGGTAGA CTGGTTTATC CACCCACAAC ATCTACGAAT CGTACTTCTT TAATTGATCT AATTTACATA TTCTGCGTGT TGTATTCAGC ACTAAAAAAT GGTGGGAGCT GGGGGAGAAT GAAGACTGTT AAATGAAACC AGAAGGATAT TTACTACTTT TGCATGAAAA TAGAGCTTTC AAGTACATGG CTAGCTTTTA TGGCAGTTCT GGTGAATGTT CAATGGGAAC TGGTCACCAT GAAACTTTAG AGATTAACGA CAAGATTTTC TACTTTTTTT AAGTGATTTT TTTGTCCTTC AGCCAAACAC AATATGGGCT CAAGTCACTT TTATTTGAAA TGTCATTTGG TGCCAGTATC CCGAATTC-3'

(FRAG. NO: ) (SEQ ID NO: 2471)

5'-GAATTCGGGA AAAAGTGAAG GTGTAAAAGC AGCACAAGTG CAATAAGAGA TATTTCCTCA AATTTGCCTC AAGATGGAAA CCCTTTGCCT CAGGGCATCC TTTTGGCTGG CACTGGTTGG ATGTGTAATC AGTGATAATC CTGAGAGATA EPI-109 206

CAGCACAAAT CTAAGCAATC ATGTGGATGA TTTCACCACT TTTCGTGGCA CAGAGCTCAG CTTCCTGGTT ACCACTCATC AACCCACTAA TTTGGTCCTA CCCAGCAATG GCTCAATGCA CAACTATTGC CCACAGCAGA CTAAAATTAC TTCAGCTTTC AAATACATTA ACACTGTGAT ATCTTGTACT ATTTTCATCG TGGGAATGGT GGGGAATGCA ACTCTGCTCA GGATCATTTA CCAGAACAAA TGTATGAGGA ATGGCCCCAA CGCGCTGATA GCCAGTCTTG CCCTTGGAGA CCTTATCTAT GTGGTCATTG ATCTCCCTAT CAATGTATTT AAGCTGCTGG CTGGGCGCTG GCCTTTTGAT CACAATGACT TTGGCGTATT TCTTTGCAAG CTGTTCCCCT TTTTGCAGAA GTCCTCGGTG GGGATCACCG TCCTCAACCT CTGCGCTCTT AGTGTTGACA GGTACAGAGC AGTTGCCTCC TGGAGTCGTG TTCAGGGAAT TGGGATTCCT TTGGTAACTG CCATTGAAAT TGTCTCCATC TGGATCCTGT CCTTTATCCT GGCCATTCCT GAAGCGATTG GCTTCGTCAT GGTACCCTTT GAATATAGGG GTGAACAGCA TAAAACCTGT ATGCTCAATG CCACATCAAA ATTCATGGAG TTCTACCAAG ATGTAAAGGA CTGGTGGCTC TTCGGGTTCT ATTTCTGTAT GCCCTTGGTG TGCACTGCGA TCTTCTACAC CCTCATGACT TGTGAGATGT TGAACAGAAG GAATGGCAGC TTGAGAATTG CCCTCAGTGA ACATCTTAAG CAGCGTCGAG AAGTGGCAAA AACAGTTTTC TGCTTGGTTG TAATTTTTGC TCTTTGCTGG TTCCCTCTTC ATTTAAGCCG TATATTGAAG AAAACTGTGT ATAACGAGAT GGACAAGAAC CGATGTGAAT TACTTAGTTT CTTACTGCTC ATGGATTACA TCGGTATTAA CTTGGCAACC ATGAATTCAT GTATAAACCC CATAGCTCTG TATTTTGTGA GCAAGAAATT TAAAAATTGT TTCCAGTCAT GCCTCTGCTG CTGCTGTTAC CAGTCCAAAA GTCTGATGAC CTCGGTCCCC ATGAACGGAA CAAGCATCCA GTGGAAGAAC CACGATCAAA ACAACCACAA CACAGACCGG AGCAGCCATA AGGACAGCAT GAACTGACCA CCCTTAGAAG CACTCCTCGG TACTCCCATA ATCCTCTCGG AGAAAAAAAT CACAAGGCAA CTGTGAGTCC GGGAATCTCT TCTCTGATCC TTCTTCCTTA ATTCACTCCC ACACCCAAGA AGAAATGCTT TCCAAAACCG CAAGGGTAGA CTGGTTTATC CACCCACAAC ATCTACGAAT CGTACTTCTT TAATTGATCT AATTTACATA TTCTGCGTGT TGTATTCAGC ACTAAAAAAT GGTGGGAGCT GGGGGAGAAT GAAGACTGTT AAATGAAACC AGAAGGATAT TTACTACTTT TGCATGAAAA TAGAGCTTTC AAGTACATGG CTAGCTTTTA TGGCAGTTCT GGTGAATGTT CAATGGGAAC TGGTCACCAT GAAACTTTAG AGATTAACGA CAAGATTTTC TACTTTTTTT AAGTGATTTT TTTGTCCTTC AGCCAAACAC AATATGGGCT CAAGTCACTT

TTATTTGAAA TGTCATTTGG TGCCAGTATC CCGAATTC-3' (FRAG. NO: ) (SEQ ID NO: 2482)

5'-GAATTCGGGA AAAAGTGAAG GTGTAAAAGC AGCACAAGTG CAATAAGAGA TATTTCCTCA AATTTGCCTC AAGATGGAAA CCCTTTGCCT CAGGGCATCC TTTTGGCTGG CACTGGTTGG ATGTGTAATC AGTGATAATC CTGAGAGATA CAGCACAAAT CTAAGCAATC ATGTGGATGA TTTCACCACT TTTCGTGGCA CAGAGCTCAG CTTCCTGGTT ACCACTCATC AACCCACTAA TTTGGTCCTA CCCAGCAATG GCTCAATGCA CAACTATTGC CCACAGCAGA CTAAAATTAC TTCAGCTTTC AAATACATTA ACACTGTGAT ATCTTGTACT ATTTTCATCG TGGGAATGGT GGGGAATGCA ACTCTGCTCA GGATCATTTA CCAGAACAAA TGTATGAGGA ATGGCCCCAA CGCGCTGATA GCCAGTCTTG CCCTTGGAGA CCTTATCTAT GTGGTCATTG ATCTCCCTAT CAATGTATTT AAGCTGCTGG CTGGGCGCTG GCCTTTTGAT CACAATGACT TTGGCGTATT TCTTTGCAAG CTGTTCCCCT TTTTGCAGAA GTCCTCGGTG GGGATCACCG TCCTCAACCT CTGCGCTCTT AGTGTTGACA GGTACAGAGC AGTTGCCTCC TGGAGTCGTG TTCAGGGAAT TGGGATTCCT TTGGTAACTG CCATTGAAAT TGTCTCCATC TGGATCCTGT CCTTTATCCT GGCCATTCCT GAAGCGATTG GCTTCGTCAT GGTACCCTTT GAATATAGGG GTGAACAGCA TAAAACCTGT ATGCTCAATG CCACATCAAA ATTCATGGAG TTCTACCAAG ATGTAAAGGA CTGGTGGCTC TTCGGGTTCT ATTTCTGTAT GCCCTTGGTG TGCACTGCGA TCTTCTACAC CCTCATGACT TGTGAGATGT TGAACAGAAG GAATGGCAGC TTGAGAATTG CCCTCAGTGA ACATCTTAAG CAGCGTCGAG AAGTGGCAAA AACAGTTTTC TGCTTGGTTG TAATTTTTGC TCTTTGCTGG TTCCCTCTTC ATTTAAGCCG TATATTGAAG AAAACTGTGT ATAACGAGAT GGACAAGAAC CGATGTGAAT TACTTAGTTT CTTACTGCTC ATGGATTACA TCGGTATTAA CTTGGCAACC ATGAATTCAT GTATAAACCC CATAGCTCTG TATTTTGTGA GCAAGAAATT TAAAAATTGT TTCCAGTCAT GCCTCTGCTG CTGCTGTTAC CAGTCCAAAA GTCTGATGAC CTCGGTCCCC ATGAACGGAA CAAGCATCCA GTGGAAGAAC CACGATCAAA ACAACCACAA CACAGACCGG AGCAGCCATA AGGACAGCAT GAACTGACCA CCCTTAGAAG CACTCCTCGG TACTCCCATA ATCCTCTCGG AGAAAAAAAT CACAAGGCAA CTGTGAGTCC GGGAATCTCT TCTCTGATCC TTCTTCCTTA ATTCACTCCC ACACCCAAGA AGAAATGCTT TCCAAAACCG CAAGGGTAGA CTGGTTTATC CACCCACAAC ATCTACGAAT CGTACTTCTT TAATTGATCT AATTTACATA TTCTGCGTGT TGTATTCAGC ACTAAAAAAT GGTGGGAGCT GGGGGAGAAT GAAGACTGTT AAATGAAACC AGAAGGATAT TTACTACTTT TGCATGAAAA TAGAGCTTTC AAGTACATGG CTAGCTTTTA TGGCAGTTCT GGTGAATGTT CAATGGGAAC TGGTCACCAT GAAACTTTAG AGATTAACGA CAAGATTTTC TACTTTTTTT AAGTGATTTT TTTGTCCTTC AGCCAAACAC AATATGGGCT CAAGTCACTT

TTATTTGAAA TGTCATTTGG TGCCAGTATC CCGAATTC-3' (FRAG. NO: ) (SEQ ID NO: 2470)

5'-GCCACCATGG AAACCCTTTG CCTCAGGGCA TCCTTTTGGC TGGCACTGGT TGGATGTGTA ATCAGTGATA ATCCTGAGAG ATACAGCACA AATCTAAGCA ATCATGTGGA TGATTTCACC ACTTTTCGTG GCACAGAGCT CAGCTTCCTG GTTACCACTC ATCAACCCAC TAATTTGGTC CTACCCAGCA ATGGCTCAAT GCACAACTAT TGCCCACAGC AGACTAAAAT TACTTCAGCT TTCAAATACA TTAACACTGT GATATCTTGT ACTATTTTCA TCGTGGGAAT GGTGGGGAAT GCAACTCTGC TCAGGATCAT TTACCAGAAC AAATGTATGA GGAATGGCCC CAACGCGCTG ATAGCCAGTC TTGCCCTTGG AGACCTTATC TATGTGGTCA TTGATCTCCC TATCAATGTA TGGCTGGGCG CTGGCCTTTT GATCACAATG ACTTTGGCGT ATTTCTTTGC AAGCTGTTCC CCTTTTTGCA GAAGTCCTCG GTGGGGATCA CCGTCCTCAA CCTCTGCGCT CTTAGTGTTG ACAGGTACAG AGCAGTTGCC TCCTGGAGTC GTGTTCAGGG AATTGGGATT CCTTTGGTAA CTGCCATTGA AATTGCCTCC ATCTGGATCC TGTCCTTTAT CCTGGCCATT CCTGAAGCGA TTGGCTTCGT CATGGTACCC TTTGAATATA GGGGTGGACA GCATAAAACC TGTATGCTCA ATGCCACATC AAAATTCATG GAGTTCTACC AAGATGTAAA GGACTGGTGG CTCTTCGGGT TCTATTTCTG TATGCCCTTG GTGTGCACTG CGATCTTCTA CACCCTCATG ACTGGTGAGA TGTTGAACAG AAGGAATGGC AGCTTGAGAA TTGCCCTCAG TGAACATCTT AAGCAGCGTC GAGAAGTGGC AAAAACAGTT TTCTGCTTGG TTGTAATTTT TGCTCTTTGC TGGTTCCCTC TTCATTTAAG CCGTATATTG AAGAAAACTG TGTATAACGA GATGGACAAG AACCGATGTG AATTACTTAG TTTCTTACTG CTCATGGATT ACATCGGTAT TAACTTGGCA ACCATGAATT CATGTATAAA CCCCATAGCT CTGTATTTTG TGAGCAAGAA ATTTAAAAAT TGTTTCCAGT CATGCCTCTG CTGCTGCTGT TACCAGTCCA AAAGTCTGAT GACCTCGGTC CCCATGAACG GAACAAGCAT CCAGTGGAAG AACCACGATC AAAACAACCA CAACACAGAC CGGAGCAGCC ATAAGGACAG CATGAACTGA CCACCCTTAG AAGCACTCCT-3' (FRAG. NO:_) (SEQ ID NO: 2469)

Substance P Antisense Nucleic Acids and Oligonucleotide Antisense Oligonucleotide Fragments S'-CTGCTGBGGC TTGGGTCTCC GGGCGBTTCT CTGCBGBBGB TGCTCBBBGG GCTCCGGCBG TTCCTCCTTG BTCTGGTCGCT GTCGTBCCBG TCGGBCCBGT BBTTCBGBTC BTCBTTGGCT CCTBTTTCTT CTGCBBBCBG CTGBGTGGBG BCBBGBBBBB BGBCTGCCBB GGCCBCGBGG BTTTTCBTGT TGGBTTTTGC GBCGGBCBGT CCCGCGGGGT GCTGAGTTTC TCTGGTTCCT CCGBGCGCBC GTGGTCGCTC CGCGTTTCTC TGGTTCCTCC GGTCCCGCGG GGTGCTGTCT GGTCGCTGTC GTGGCTTGGG TCTCCGGGCG GTTTCCTTCC TTTTCCGC-3' (FRAG. NO:1877) (SEQ ED NO: 1888) EPI-109 207

5'-CTCC GGGCGB-3' (FRAG. NO:1878) (SEQ ID NO: 1889) 5 -GGCCBCGBGG-3' (FRAG. NO:1879) (SEQ ED NO: 1890) 5'-GGGTCTCCGGGCG-3' (FRAG. NO:1880) (SEQ ID NO: 1891) 5 -GGG TCTCCGGGCG G-3' (FRAG. NO:1881) (SEQ ID NO:1892) 5 -CGTGGTCGCTCCGC-3' (FRAG. NO:1355)(SEQ. ID NO:1365) 5'-GTTTCTCTGGTTCCTCCG-3' (FRAG. NO:1356)(SEQ. ID NO:1366) 5 -GTCCCGCGGGGTGCTG-3' (FRAG. NO:1357)(SEQ. ED NO:1367) 5 -TCTGGTCGCTGTCGT-3' (FRAG. NO:1358)(SEQ. ED NO:1368) 5 -GGCTTGGGTCTCCGGGCG-3' (FRAG. NO:1359)(SEQ. ED NO:1369) 5'-GTTTCCTTCCTTTTCCGC-3' (FRAG. NO:1360)(SEQ. ID NO:1370)

5'-CTGCTGBGGC TTGGGTCTCC GGGCGBTTCT CTGCBGBBGB TGCTCBBBGG GCTCCGGCBG TTCCTCCTTG BTCTGGTCGCT GTCGTBCCBG TCGGBCCBGT BBTTCBGBTC BTCBTTGGCT CCTBTTTCTT CTGCBBBCBG CTCBGTGGBG BCBBGBBBBB BGBCTGCCBB GGCCBCGBGG BTTTTCBTGT TGGBTTTTGC GBCGGBCBGT CCCGCGGGGT GCTGAGTTTC TCTGGTTCCT CCGBGCGCB-3' (FRAG. NO:1882) (SEQ ID NO: 1893)

Substance P Receptor Nucleic Acids and Antisense Oligonucleotide Fragments

5 -GGGCTBBGBT GBTCCBCBTC BCTBCCBCGT TGCCCBCCBC BGBGGTCBCC BCBBTGBCCG TGTBGGCBGC TGCCCBBBGG BCBBTTTGCC BGGCTGGTTG CBCGBBCTGB TTGGGTTCCG BGGTGTTBGT GGBGBTGTTT GGGGBGBGGT CTGBGTCCBC CGGGBGGBCG TTBTCCBTTT CGBBGCTBGG CGGTBBBGCC CTBCTBTCTG TBCBCBBCCC CCCTCTGCBG CBGBGTCCTG TCGTGGCGCC TGGGGCTCBG GGTCCGGGC TAAGATGATC CACATCACTA CCACGTTGCC CACCACAGAG GTCACCACAA TGACCGTGTA GGCAGCTGCC CAAAGGACAA TTTGCCAGGC TGGTTGCACG AACTGATTGG GTTCCGAGGT GTTAGTGGAG ATGTTTGGGG AGAGGTCTGA GTCCACCGGG AGGACGTTAT CCATTTCGAA GCTAGGCGGT AAAGCCCTAC TATCTGTACA CAACCCCCCT CTGCAGCAGA GTCCTGTCGT GGCGCCTGGG GCTCAGGGTC CGTCCTGTCG TGGCGCCTGG GGCTCTTCTT TTGTGGGCTC TTTGGTGGCT GTGGCTGTGG TCTCTGTGGT TGCTGCCCTG GGTCTGGGGG TGTGGCCTTG GGGCCGTCCT CTGGCTCCTC CTCGTGGGCC CCC-3' (FRAG. NO:1883) (SEQ. ID NO:1894) 5 -GGGBGGBCG-3' (FRAG. NO:1884) (SEQ. ID NO:1895) 5 -GGGTC CG-3' (FRAG. NO:1885) (SEQ. ID NO:1896) 5- GGGCC CCC-3' (FRAG. NO:1886) (SEQ. ID NO:1897)

5'-GTCCTGTCGTGGCGCCTGGGGCTC-3' (FRAG. NO:1361)(SEQ. ID NO:1371) 5'-TTCTTTTGTGGGCT-3' (FRAG. NO:1362)(SEQ. ID NO:1372) 5'-CTTTGGTGGCTGTGGCTG-3' (FRAG. NO:1363)(SEQ. ID NO:1373) S -TGGTCTCTGTGGTTG^' (FRAG. NO:1364)(SEQ. ID NO:1374) 5'-CTGCCCTGGGTCTGG-3' (FRAG. NO:1365)(SEQ. ID NO:1375)

5'-GGGTGTGGCCTTGGGGCCGTCCTCTGGCTCCTCCTCGTGGGCCCCC (FRAG. NO:1366)(SEQ. ID NO:1376) 5'-GGGCTAAGAT GATCCACATC ACTACCACGT TGCCCACCAC AGAGGTCACC ACAATGACCG TGTAGGCAGC TGCCCAAAGG ACAATTTGCC AGGCTGGTTG CACGAACTGA TTGGGTTCCG AGGTGTTAGT GGAGATGTTT GGGGAGAGGT CTGAGTCCAC CGGGAGGACG TTATCCATTTC GAAGCTAGGC GGTAAAGCCC TACTATCTGTA CACAACCCCC CTCTGCAGCA GAGTCCTGTC GTGGCGCCTG GGGCTCAGGGTCC-3' (FRAG. NO:1367)(SEQ. ID NO:1377) 5'-GGGCTBBGBT GBTCCBCBTC BCTBCCBCGT TGCCCBCCBC BGBGGTCBCC BCBBTGBCCG TGTBGGCBGC TGCCCBBBGG BCBBTTTGCC BGGCTGGTTG CBCGBBCTGB TTGGGTTCCG BGGTGTTBGT GGBGBTGTTT GGGGBGBGGTC TGBGTCCBCC GGGBGGBCGT TBTCCBTTTC GBBGCTBGGC GGTBBBGCCC TBCTBTCTGTB CBCBBCCCCC CTCTGCBGCB GBGTCCTGTC GTGGCGCCTG GGGCTCBGGG TCC-3' (FRAG. NO:1368) (SEQ. ID NO:1378)

Chvmase Antisense Nucleic Acids and Oligonucleotides Antisense Oligonucleotide Fragments 5 -GGBGCTGBTB CTGCBGATTT CBGBGGGBBG BBCCCTGBTB CTCBCCBGCT TCBGCTCTGG BGCBCBBGBG BBBGBGCBGC BGGGGGBGBG GBBGBBGCBG CBTCTTCCCB GBGBGGCTGC CTGBGCBBBT GCTGGTTTTC CTTTCCBGTC TTGGGTTTTB TBBCTCCCBG BBGGCBBGBG BGGGGCBBGG CGTTTTCTTC TCTCGCTGGT TTTCCTTTCC TGGCAGTGGG TGGGGGTGGG GGTGGGGTGG CTTCCTTGTT CCTGGGGGTG TCCTCTTGCT CTGGGCTTTT CTCCCCTTTT CCTTCCTGTC TGTTTTCCTG GGGCTCTCCT CTGTCTCTGT GTCCTTGCCC TGGCCCTCTT CCCTCTCCTG TCTCCTGTCC CTGTGTTCCG CCCGTCTTCC CTCTCCTGAC CTCCTTTTCC TCCGCTGGGT GGGGCCCTGC CTGTTCTCTG CTCCCTGGCT TGGGGTTTCT TCTGTGTGTC TTCTTCCTCT GTTGGCTGGC TTTCTCCTTC TTTTGTCTTC CTGGGTGCCC CTTCTTCCTT TCTTGGGTCC TTGGTGCTTG GGCTGGG TCCCAGTTAA TACATAATCA ATATGCAATT TATTAATACA TCTCTCCATG TCCACTCCCC CTGTATCTTG CCATTCTTGA CCTGCATTTC CATCCTCCTT ACCTTCCCTA GAGGCCAACT CATTTTCTTT GAAAAACCTG GCATTTCCCA GAAAAAAAAG TGAAGGGCTG GGAGCTGTCC GTTGTCCTGA TTTGCTCCCT CTGCCCTTGC TTCCAAATGT GGTTGGAAAG AAGCACTATT GAAAAATCCC TAAACGCACC CCTGCAGGGT TGGCTCTACC CTGTAGCCAT GGACACATGC TGTTGATACC ACCTGCCTCA TGAGTCTCAC ATAATTTGCC CTTTCACACT ATCTACCCCA TCAGCCTTAC CAAAACCATA CCTGCATCCT GGGCAGCATC TGCCCTTCAA GAGACTAAGG AATCTCCTTG CAACCAAGAA TGACTAGACC AATGAGACAC CCTTTAAGGC CCCAGCACAA TATAGAAATC CCACAATATG GTAATCCCAG TAAGGAGCTA TCAAGCCATT GCAGGACCAT CTAGAATACA ACTAGAGTAT AGTTCCTTTC AATCCAGGAA CTATACTCTA ACAGCTTGGC TCACAGGAAC CAGAAGTGAA GATGATGAGG ATCAGGGCTG AGCCTGTGAG CACCAGCTCC ACCACTGACA CCAACCACAG ATTAAACAAG CATCTTGTGG ACCCCTGGGA TGGAAAGAAT AGTTGTTGCC TTATCAACCT CCCCCACAGC CCACACAGAA AAGATAAAAT CATCATGGCT ACAGTGTTAC AGAAGATGAT GACCCAAGGA GTAGGCCTGC CTGAGTGAAT GCTGAGAGTG ATAATGGGAG CAGTAGCATC TCAGAGACTA CAGCAGAAAC CATCCACATA AAGAGCTTTG CCCAAACTTA TGATAAAGGG CACCCTCAGA GACTCTCCCT ACTTTAATAT TAGCCCATTG CAGAAATGGT GAGTGGAAAG AGAAATCTTA GGAAGAACCC CTTAAAAAAG CAAAATGCTT TTTAGGTTTG TGCTGAAGAG CCTGGAAAAG AAATAAGGAC ACACACGCTG AGAAATCTTC CTCCTGCCCC AACACTGGGA TAATCTCCAA GGATCTCTCC ATATCTCATT CTCCTGGATA CACTGTCCAC TCAGAAATAT TGTGCAGAGT GCAGTAATTC AAAAGTGAGC TATTGTGTTA GGAGTGAAGG CAAGAGTATC GTAAAATAAA TCAAATTTGA AATGAATTCT CTTAAATTGC TTTATAGATG TTTAATGTAA GCCAGCAGCT ATTAAACGAT AAACCTTAAA TTCGAGAAAA ACTTGGTCAT TCAGAAACTA TAGAAACAGG CAGGACTTAT TGCGAGGGCA AACACAGAGT GAGCTCCAGC CTGCTTCAGG AAAATCTGCC AGTGCCATGA AGGATGTACT CTGTCTGCTC CACTGCACTA CTGCTCAGTA TGAGCCCATG CCATCAGCTG TCCCTGACCC ACAGGAGTTC TTTAGAAGAG ACTGGTCAAC AAAAGTTTCT AGGGTGTTTT ATACCTGCCA ACTCGAGGGT TAAAACAAGT TGCATAGAAA TGCTCAATCA EPI-109 208

AGAAAGACAC AGTCATTACT CAGAGAATAA TAAACAGCCT GGCAGCACAT GAATGAATAG AAAAAAGATG TTACATGCAA AGCATGAAAT AACCAAATTC CATAACAGAT GTTAATCTGT AATGTGTTTA GGAGAATTTA GAGGAAGTAT AAGATTTATT CTTTCATCAA AAAAATTATA GCCAATGAGG ATATATCTAT CAATTATCCA TCAAGTGGTG ATATGGCAGC ACAAGGTAAA ACACAAAGGA ATAAAACCAA CGTTTATTAA GAACCAATCA TGTGGCATTT CACATTGAGC ATCATATTTA ATTCTGAAAA AAATCCTTGT ACTGTATCAT TCTTCATATT TTATGGATGC AGTAACTAAG GCTGAGAACT TTAAAATTTT TCCTAAGTTC AGACACATAG CTAAGTGGCA GAACCAAGAT TCAAACTCAC CCCATCTAAC TGCAGAGCAA ACTGCATGCC TTAAATGTCA AAGTGAATAC TAGCACAGTT AATACAATGT TTGGAAACTC AGAGAAGGAA TGATCCCTCT GCATTATAGT TACTAAGGAA TCATTGCCAT TATTTAAATG CCAGTGCTTC TACATCAGGC CCAAATTTTC TGTCCTACTA ACTGTGAATC AAGACTTGAT TCAACCTCTA CTTCAGTATC TGCCGCAATG AGAAATCACT TACCTCCACT AACCACACAT TTATTTTATA ACAACAGATT GTTAGTAAGT CCTTTCTTAT ACATACTCAA CAGCTGCTTC CCAAGATGCT GTAGGATTAT GTCTAGAGTC AAACTAGCCA GAAGCAATGT CCAAAATACA CCATAACACT GTGCAGCAAA GGTCCTACTA CCACTTGTTT GGCCCAAACA TTCTAGGCAG CACTGGATAT CTGAATCATC AATTATTTCC ACAAACACTG ACCCCTCTAC CAGTCACCCT CACTAGAAGA ATTAATTCCA CATGATAATA GCTCCCTCAT GTTACTCCCT TCTAAGTCAA ATTGTACACC CCTTTATCTG ATTAACAGAG TCTAAGTCAC ATGACCTAAA TGCAAGAGAA CTGGGAATGG ACGTTTGTGG ATTCTACCTT AGTAAGGCAA AGTTATCATT GGGAATTCCT CTAATACAGG AAGGGTGTTC CAGAGACATT AAGGAGCCAT ATAAATGGAA AATGTCCACT ACAATCCATC ACTTGGTTGC CCCACATCAA CATTCATTCT TTTGCCACAC TTAAAGTTTC CAAGAACAAA AATTATCCCA CTGAACATAA TCTTTACTAT CTTTTATATA AAGGAAAATT AGACTTGACT CAGCAGAACT GAAATAACCC AGCTCTAACA GTTACTGCTT TTAACTTCAA GTACTGTGTC TCTAGGTGAT ACCTGCTCCA ACAATAGTTT GGTCACATTT TCAATTTGAT ATTCTCTAGT CTCCCAACTT GATAACTGTA CCCTAAACCA TAAAGTTCAC TACCAACATG CTATATATAA AATAACCAAA GGGGGAAGAA GAAAGAGAAA AAGGAAATCT CTTAAAATAC ACAGGTATAC ATATGACAAA GCAAAGAAGG AAATGTGAGC AGATAGTGCA GTCCTCGTTT CTGAAATTGG TCCCCTGACT GGGGCTATAC CTATTCCATT TCCTCACCCT CAGCCAGGCA GGTGGAGCAA AAACTTAAGT CTTGGTGGAT CTGAATCTTG ATGCTGTGGA GCTGTCTTAC TAGCCCCAGA CTACCTGCCT CTCAATTTCT AATTATATCA GTGAAAGCAA ACAGCTTTGA TTTGTTTAAG CCTCTGATTT TTTGGTCTAA CTGATGTAAG ACCACAAGGA CAAGAGTTCT CCAGCTCCGG ATTCTCTTCT GTTCTGTTAA TGGTGAAATG CCCGAGAGAA GAGTTGCCAA CTTTGGCAAA TAAAAAATAC AGGATTCCAG TTAAATTCAA ATTTAGATAA ACAACAATTT TTTAGTATTA GTGTGTCCCA TTCAATATTT GGACATACTT AACTAAAAAA TGATTTGTTG TTCATCTGAA ATACAAATTT AACTGGGCAT TCTGAATATT CTCTGGCAAC CCCCGAGAGA GTGAAGAAAG TGGTACAAGG ACACTTAAGA AGACCAGATT TGAAAAGACA TTACGGATGT GTTTAAATGT CTTATTCTAG AGAGAGTTAG AGCTGTAGGT AGAACTTGGG AAATTAAGTT AAAAGCAGAC ACAGAGACCT GGCCAATATA TACTAAGGAG TGGATCACTC TGGTCACAAG CCCAACCTGA GACCAAGGGC ATAGTGAGAT GATTTGGGAA AGGCACTTAT ACACTACTCA TCCCCGTCTT TGAACTAAAT GCCTTATAAA TCTCCAAGAG AAATGACAGT CCACCATGTG GACTGCTTTC TGTAAGTCCA GGGAAAATAA AAGCTATGTG CTTGAAACCC ACTTCTGATA TTATAAGGTG TGTGATCTTT GTCATGTTAA TGGGTCTGAG TATCAATTCT ACAATTGTAA AGTGACAGTA ATGGTGTGTC CCCAGGTTGT TGTGGAAAGC TTGATTCTTA ATGCAACAGT AGGAAACCCC AGCCTCTCTG GAGCAAACAC CCTTCTACAT CTTTACTTCC CCTGCACATT GGCAGGACTC TATTCCTCTA TTTCTCTCTA GTGCTAGAGC AGAAAGGGAC CTTGATTTGA TATCAGGAAA ATCTATTTCT GAACCATAAG CTATGATAGC TGATTTAAAA AATTGACTAT CATGACATGA TAATGATCAT AATGGTAATA CATATTGATA GGGTTGCCGT GAAAGTAATA ATATATCTAA GAGTTGTGAC AATATATGAT ACGCCTAGAC TCTCAGAAAA TGCTAATTCC AATCCCAATT GCTCTTTGCA TAAAGTTCTG TCCTAGGGTC TGTTCTTTTC CCACATCTAC CCTCCTTGGA TCTCTCTTCT GTCTTTTTCA TGTGGTTCAG AGGAGGAGAG AGATCCAGGT CAATGTTTTT CAAATTACAA GGAATTATCA TTTAAATGGG GAAGAAGCTC AAGTTTTGAC GTGTAGTGGA ATTGGAGTGG AGTGGAGTGG AATGGAAACT AACAGGAAGA CACTGCACAT GGTTAAGATA AAGATTGTTT CCTGAAACCT TTAATTTGTG CTTACATACT CACACATACA TATGTGCATG CACTGGGACT CTGCAATATG CATTTCTGAC TATGGAACAT AGCCATAAAA GTCTTTGCAC TGAACGTTCA GTGGGCCTTT CACAAGCTGC CCTAATTGGG AAAGAAAAAC ATGGTCCCTC CATTTCCTGC CCCCAACTCC AGAAAAGTCA CCATAGTTGA GGGTACATCT GAGAAGCCAG CACTTGGGAG TTCAGGGCTC AAGTTCCTTT CTAGAAAAAC ACTGGGTGAT TCTAGGGGAA CTTCCGATCA GAAACAGCCA ATTCAGAGTG AGAGAAGAAA ACGTGACCAT GCAGTTCCTG TGGTTACCAG CCTTGCCCCT CTCTTGCCTT CTGGGAGTTA TAAAACCCAA GACTGGAAAG GAAAACCAGC ATTTGCTCAG GCAGCCTCTC TGGGAAGATG CTGCTTCTTC CTCTCCCCCT GCTGCTCTTT CTCTTGTGCT CCAGAGCTGA AGCTGGTGAG TATCAGGGTT CTTCCCTCTG AAATCTGCAG TATCAGCTCC TGAAACAAAG ATGTTTAGTC TGAAATAGCT GACTCCTAAA CAGGGTTCCA AGATCTCTCT TCAAGAGTCC CACAGAGGAA ATTTCCACTT GGGATGTGTG CCACCCCACC CCCACCCCCA CCCACTGCCA TTCTCTACAG CCTAGGACAC CCCCAGGAAC AAGGAATTTC ACCTCAATTG TAGAAAAGCC CAGAGCAAGT GGAAGGAAAA GGGGTATCCC CAGGAAAACA GACATGTCCT CTTAATCTTC TGAGCATCAG GGCTACCCAT TACTTTGTGA CTTTCTCACT CTGTGACCAT GCTCAAGAGC TATGGAGAAA TCTAAAACAG GAACCTGGAC AGTGGGTCCT ACACAGAGAC AGAGGAGAGT GGGCCAGGGC AAGGTGGGAG TGGGAGAAGT CTGAGATGAA AACATCAGAA TGGAGCAGAG GCAAGAATGA GATTTCACCT GGGAGGTTAT GGGTGGGGAA AGATACGAAA TACAGGAGAC AGGAGAGGGA AGATGGGCGG AACACAGGGT GAGAATGAGA TTCCAGGGAA GCCTAGCTCA GCTTTAACCC AATTTGTCCA TTCATTGGAG AGAGTATCTA TGGCCGTGTT CAAACCCTGG GGTGCTCTGT TCCAGGGGAG ATCATCGGGG GCACAGAATG CAAGCCACAT TCCCGCCCCT ACATGGCCTA CCTGGAAATT GTAACTTCCA ACGGTCCCTC AAAATTTTGT GGTGGTTTCC TTATAAGACG GAACTTTGTG CTGACGGCTG CTCATTGTGC AGGAAGGTGA GACAACAGGG TCTATTTATC TCCAAATGGG AGATGAACAA CCAGAGTAGC ATCCAGGAAT ACACCTGCAC TGGGGACTGA AGAGGGGGTC CTGGGTCTTG TCAACTTTCA GGAGAGGGAA GACTTTGGGC TGAAAGACTT TAGTCTGTGT TTGAATAGTT CCTTGAGCCT CAGTCACTGA GCTAAGCTCC CTTCGGAGGA AAAGGAGGTC CTGTCCGAAG GTCCCTCTTG TTGCAGTAGC ACCCCTCACC CCTACCCAAC TCAAGACACA CGGCTCACTT TTCAGGGCCC CACCCAGTCT CAGGGCCACT TCCTCTATGG CCTTTTCAAG AACACTGGCT CTAGTTCTCA GGGTCCTGAA CCCATCATTT TATGGGAGCA GAGAACAGGT CTACATAAGA CCCCCACTTT CCCGTTTTAA CTGATATCTC CTGCTTCAGG GGCTGGCCCT CATGCAGGGT TCCCTGAATT AGGAAGTGTG AACCCTGTCC CCTGAGTCCT CCCTGGCCTG TTCAGTCCCC AGCAATTCCA GGGGTCGTAG AAATTGTGTC TGTTTCCTGA GAAAGCTCTT TCATGAGTTA AGCCTGAGCC CTCAAATGCC ACAAGTGGCC CATGAAAAGG GAGATGGGTA GAGTCCGGCN ACCCAGTGAC AGAGTTTAGT CCTCTTTTCT CAGAATGAGC TCACCTCAGA AGAAACCCCA AGCCATCACT GTCGCCTCCT TTTCCTTCCT TCTTCCTCAC AGCAGGTCTA TAACAGTCAC CCTTGGAGCC CATAACATAA CAGAGGAAGA AGACACATGG CAGAAGCTTG AGGTTATAAA GCAATTCCGT CATCCAAAAT ATAACACTTC TACTCTTCAC CACGATATCA TGTTACTAAA GGTGACAACA CCTCTCTTCT CCCTTTCCAC TTCCCATTCT CCTAAGCTTC TCCTTCAGGT CCTCATTGCC CTGAATTTTT CTTAGGACTT GGCTATAACA TGAAGCTACT CACCCTGTCC CTCCCTGATC ACCTCCAACT GTCCAGAGCC CATTTCGAGG ACTGACAGTC CTTCATTCCC EPI-109 209

TTCACAGTTG AAGGAGAAAG CCAGCCTGAC CCTGGCTGTG GGGACACTCC CCTTCCCATC ACAATTCAAC TTTGTCCCAC CTGGGAGAAT GTGCCGGGTG GCTGGCTGGG GAAGAACAGG TGTGTTGAAG CCGGGCTCAG ACACTCTGCA AGAGGTGAAG CTGAGACTCA TGGATCCCCA GGCCTGCAGC CACTTCAGAG ACTTTGACCA CAATCTTCAG CTGTGTGTGG GCAATCCCAG GAAGACAAAA TCTGCATTTA AGGTGATCCT CCAACTAGGT TTCCTCTCCA AAACTCACTG TTCAGGGACC TGAATGCTCT TAGAAGGAGA TGGGGTCAGC AGGTTGTCAG TCAGGTGACA GGGTGAGCAT CACAGGAATT GCTGTCCTCC CGTGGTCCAA GACAGCCTCT GACCATCCAT TCCAGTCTAC TGCACTGGGG GCATGGGGTG ACTGTGGAGA ATGTGGATGA CGGTCCCAAG AAAGGAAGAA GGGGCATCAG AACTAGATGT ATAAGTGAGG AGCTCCACCT CCTGGGTCTG ACTTTAGGTC TCACTGTGAC TCCAAGCTGG CTGGCAGACA GGAGTGGAGG ACTTCCCGGG CTCACCTTCT TCTCTCTCTC CTCCCCCTAC AGGGAGACTC TGGGGGCCCT CTTCTGTGTG CTGGGGTGGC CCAGGGCATC GTATCCTATG GACGGTCGGA TGCAAAGCCC CCTGCTGTCT TCACCCGAAT CTCCCATTAC CGGCCCTGGA TCAACCAGAT CCTGCAGGCA AATTAATCCT GGATCCTGAG CCAGCCTGAA GGGAAGCTGG AACTGGACCT TAGCAGCAAA GTGTGTGCAA CTCATTCTGG TTCTACCCTT GGTTCCCTCA GCCACAACCC TAAGCCTCCA AGAGGTCTCC TACAGGTAAC AGAACTTTCA ATAAACTTCA GTGAAGACAC AGCTTCTAGT CGTGAGTGTG TGTCCCTCTC TGCTGCTCTC TTCTCCTGCA CATGTGACCT GATTCCCAGC CCAAGCACCA AGGA ATCATCGGGG GCACAGAATC CAAGCCACAT TCCCGCCCCT ACATGGCCTA CCTGGAAATT GTAACTTCCA ACGGTCCCTC AAAATTTTGT GGTGGTTTCC TTATAAGACG GAACTTTGTG CTGACGGCTG CTCATTGTGC AGGAAGGTCT ATAACAGTCA CCCTTGGAGC CCATAACATA ACAGAGGAAG AAGACACATG GCAGAAGCTT GAGGTTATAA AGCAATTCCG TCATCCAAAA TATAACACTT CTACTCTTCA CCACGATATC ATGTTACTAA AGTTGAAGGA GAAAGCCAGC CTGACCCTGG CTGTGGGGAC ACTCCCCTTC CCATCACAAT TCAACTTTGT CCCACCTGGG AGAATGTGCC GGGTGGCTGG CTGGGGAAGA ACAGGTGTGT TGAAGCCGGG CTCAGACACT CTGCAAGAGG TGAAGCTGAG ACTCATGGAT CCCCAGGCCT GCAGCCACTT CAGAGACTTT GACCACAATC TTCAGCTGTG TGTGGGCAAT CCCAGGAAGA CAAAATCTGC ATTTAAGGGA GACTCTGGGG GCCCTCTTCT GTGTGCTGGG GTGGCCCAGG GCATCGTATC CTATGGACGG TCGGATGCAA AGCCCCCTGC TGTCTTCACC CGAATCTCCC ATTACCGGCC CTGGATCAAC CAGATCCTGC AGGCAAATTA A-3' (FRAG. NO: 1887) (SEQ. ID NO:1898)

5'-ATCATCGGGG GCACAGAATC CAAGCCACAT TCCCGCCCCT ACATGGCCTA CCTGGAAATT GTAACTTCCA ACGGTCCCTC AAAATTTTGT GGTGGTTTCC TTATAAGACG GAACTTTGTG CTGACGGCTG CTCATTGTGC AGGAAGGTCT ATAACAGTCA CCCTTGGAGC CCATAACATA ACAGAGGAAG AAGACACATG GCAGAAGCTT GAGGTTATAA AGCAATTCCG TCATCCAAAA TATAACACTT CTACTCTTCA CCACGATATC ATGTTACTAA AGTTGAAGGA GAAAGCCAGC CTGACCCTGG CTGTGGGGAC ACTCCCCTTC CCATCACAAT TCAACTTTGT CCCACCTGGG AGAATGTGCC GGGTGGCTGG CTGGGGAAGA ACAGGTGTGT TGAAGCCGGG CTCAGACACT CTGCAAGAGG TGAAGCTGAG ACTCATGGAT CCCCAGGCCT GCAGCCACTT CAGAGACTTT GACCACAATC TTCAGCTGTG TGTGGGCAAT CCCAGGAAGA CAAAATCTGC ATTTAAGGGA GACTCTGGGG GCCCTCTTCT GTGTGCTGGG GTGGCCCAGG GCATCGTATC CTATGGACGG TCGGATGCAA AGCCCCCTGC TGTCTTCACC CGAATCTCCC ATTACCGGCC CTGGATCAAC CAGATCCTGC AGGCAAATTA A-3' (FRAG. NO:) (SEQ. ID NO:2467)

S'-TCCCAGTTAA TACATAATCA ATATGCAATT TATTAATACA TCTCTCCATG TCCACTCCCC CTGTATCTTG CCATTCTTGA CCTGCATTTC CATCCTCCTT ACCTTCCCTA GAGGCCAACT CATTTTCTTT GAAAAACCTG GCATTTCCCA GAAAAAAAAG TGAAGGGCTG GGAGCTGTCC GTTGTCCTGA TTTGCTCCCT CTGCCCTTGC TTCCAAATGT GGTTGGAAAG AAGCACTATT GAAAAATCCC TAAACGCACC CCTGCAGGGT TGGCTCTACC CTGTAGCCAT GGACACATGC TGTTGATACC ACCTGCCTCA TGAGTCTCAC ATAATTTGCC CTTTCACACT ATCTACCCCA TCAGCCTTAC CAAAACCATA CCTGCATCCT GGGCAGCATC TGCCCTTCAA GAGACTAAGG AATCTCCTTG CAACCAAGAA TGACTAGACC AATGAGACAC CCTTTAAGGC CCCAGCACAA TATAGAAATC CCACAATATG GTAATCCCAG TAAGGAGCTA TCAAGCCATT GCAGGACCAT CTAGAATACA ACTAGAGTAT AGTTCCTTTC AATCCAGGAA CTATACTCTA ACAGCTTGGC TCACAGGAAC CAGAAGTGAA GATGATGAGG ATCAGGGCTG AGCCTGTGAG CACCAGCTCC ACCACTGACA CCAACCACAG ATTAAACAAG CATCTTGTGG ACCCCTGGGA TGGAAAGAAT AGTTGTTGCC TTATCAACCT CCCCCACAGC CCACACAGAA AAGATAAAAT CATCATGGCT ACAGTGTTAC AGAAGATGAT GACCCAAGGA GTAGGCCTGC CTGAGTGAAT GCTGAGAGTG ATAATGGGAG CAGTAGCATC TCAGAGACTA CAGCAGAAAC CATCCACATA AAGAGCTTTG CCCAAACTTA TGATAAAGGG CACCCTCAGA GACTCTCCCT ACTTTAATAT TAGCCCATTG CAGAAATGGT GAGTGGAAAG AGAAATCTTA GGAAGAACCC CTTAAAAAAG CAAAATGCTT TTTAGGTTTG TGCTGAAGAG CCTGGAAAAG AAATAAGGAC ACACACGCTG AGAAATCTTC CTCCTGCCCC AACACTGGGA TAATCTCCAA GGATCTCTCC ATATCTCATT CTCCTGGATA CACTGTCCAC TCAGAAATAT TGTGCAGAGT GCAGTAATTC AAAAGTGAGC TATTGTGTTA GGAGTGAAGG CAAGAGTATC GTAAAATAAA TCAAATTTGA AATGAATTCT CTTAAATTGC TTTATAGATG TTTAATGTAA GCCAGCAGCT ATTAAACGAT AAACCTTAAA TTCGAGAAAA ACTTGGTCAT TCAGAAACTA TAGAAACAGG CAGGACTTAT TGCGAGGGCA AACACAGAGT GAGCTCCAGC CTGCTTCAGG AAAATCTGCC AGTGCCATGA AGGATGTACT CTGTCTGCTC CACTGCACTA CTGCTCAGTA TGAGCCCATG CCATCAGCTG TCCCTGACCC ACAGGAGTTC TTTAGAAGAG ACTGGTCAAC AAAAGTTTCT AGGGTGTTTT ATACCTGCCA ACTCGAGGGT TAAAACAAGT TGCATAGAAA TGCTCAATCA AGAAAGACAC AGTCATTACT CAGAGAATAA TAAACAGCCT GGCAGCACAT GAATGAATAG AAAAAAGATG TTACATGCAA AGCATGAAAT AACCAAATTC CATAACAGAT GTTAATCTGT AATGTGTTTA GGAGAATTTA GAGGAAGTAT AAGATTTATT CTTTCATCAA AAAAATTATA GCCAATGAGG ATATATCTAT CAATTATCCA TCAAGTGGTG ATATGGCAGC ACAAGGTAAA ACACAAAGGA ATAAAACCAA CGTTTATTAA GAACCAATCA TGTGGCATTT CACATTGAGC ATCATATTTA ATTCTGAAAA AAATCCTTGT ACTGTATCAT TCTTCATATT TTATGGATGC AGTAACTAAG GCTGAGAACT TTAAAATTTT TCCTAAGTTC AGACACATAG CTAAGTGGCA GAACCAAGAT TCAAACTCAC CCCATCTAAC TGCAGAGCAA ACTGCATGCC TTAAATGTCA AAGTGAATAC TAGCACAGTT AATACAATGT TTGGAAACTC AGAGAAGGAA TGATCCCTCT GCATTATAGT TACTAAGGAA TCATTGCCAT TATTTAAATG CCAGTGCTTC TACATCAGGC CCAAATTTTC TGTCCTACTA ACTGTGAATC AAGACTTGAT TCAACCTCTA CTTCAGTATC TGCCGCAATG AGAAATCACT TACCTCCACT AACCACACAT TTATTTTATA ACAACAGATT GTTAGTAAGT CCTTTCTTAT ACATACTCAA CAGCTGCTTC CCAAGATGCT GTAGGATTAT GTCTAGAGTC AAACTAGCCA GAAGCAATGT CCAAAATACA CCATAACACT GTGCAGCAAA GGTCCTACTA CCACTTGTTT GGCCCAAACA TTCTAGGCAG CACTGGATAT CTGAATCATC AATTATTTCC ACAAACACTG ACCCCTCTAC CAGTCACCCT CACTAGAAGA ATTAATTCCA CATGATAATA GCTCCCTCAT GTTACTCCCT TCTAAGTCAA ATTGTACACC CCTTTATCTG ATTAACAGAG TCTAAGTCAC ATGACCTAAA TGCAAGAGAA CTGGGAATGG ACGTTTGTGG ATTCTACCTT AGTAAGGCAA AGTTATCATT GGGAATTCCT CTAATACAGG AAGGGTGTTC CAGAGACATT AAGGAGCCAT ATAAATGGAA AATGTCCACT ACAATCCATC ACTTGGTTGC CCCACATCAA CATTCATTCT TTTGCCACAC TTAAAGTTTC CAAGAACAAA AATTATCCCA CTGAACATAA TCTTTACTAT CTTTTATATA AAGGAAAATT AGACTTGACT CAGCAGAACT GAAATAACCC AGCTCTAACA GTTACTGCTT TTAACTTCAA GTACTGTGTC TCTAGGTGAT ACCTGCTCCA ACAATAGTTT GGTCACATTT TCAATTTGAT ATTCTCTAGT CTCCCAACTT GATAACTGTA EPI-109 210

CCCTAAACCA TAAAGTTCAC TACCAACATG CTATATATAA AATAACCAAA GGGGGAAGAA GAAAGAGAAA AAGGAAATCT CTTAAAATAC ACAGGTATAC ATATGACAAA GCAAAGAAGG AAATGTGAGC AGATAGTGCA GTCCTCGTTT CTGAAATTGG TCCCCTGACT GGGGCTATAC CTATTCCATT TCCTCACCCT CAGCCAGGCA GGTGGAGCAA AAACTTAAGT CTTGGTGGAT CTGAATCTTG ATGCTGTGGA GCTGTCTTAC TAGCCCCAGA CTACCTGCCT CTCAATTTCT AATTATATCA GTGAAAGCAA ACAGCTTTGA TTTGTTTAAG CCTCTGATTT TTTGGTCTAA CTGATGTAAG ACCACAAGGA CAAGAGTTCT CCAGCTCCGG ATTCTCTTCT GTTCTGTTAA TGGTGAAATG CCCGAGAGAA GAGTTGCCAA CTTTGGCAAA TAAAAAATAC AGGATTCCAG TTAAATTCAA ATTTAGATAA ACAACAATTT TTTAGTATTA GTGTGTCCCA TTCAATATTT GGACATACTT AACTAAAAAA TGATTTGTTG TTCATCTGAA ATACAAATTT AACTGGGCAT TCTGAATATT CTCTGGCAAC CCCCGAGAGA GTGAAGAAAG TGGTACAAGG ACACTTAAGA AGACCAGATT TGAAAAGACA TTACGGATGT GTTTAAATGT CTTATTCTAG AGAGAGTTAG AGCTGTAGGT AGAACTTGGG AAATTAAGTT AAAAGCAGAC ACAGAGACCT GGCCAATATA TACTAAGGAG TGGATCACTC TGGTCACAAG CCCAACCTGA GACCAAGGGC ATAGTGAGAT GATTTGGGAA AGGCACTTAT ACACTACTCA TCCCCGTCTT TGAACTAAAT GCCTTATAAA TCTCCAAGAG AAATGACAGT CCACCATGTG GACTGCTTTC TGTAAGTCCA GGGAAAATAA AAGCTATGTG CTTGAAACCC ACTTCTGATA TTATAAGGTG TGTGATCTTT GTCATGTTAA TGGGTCTGAG TATCAATTCT ACAATTGTAA AGTGACAGTA ATGGTGTGTC CCCAGGTTGT TGTGGAAAGC TTGATTCTTA ATGCAACAGT AGGAAACCCC AGCCTCTCTG GAGCAAACAC CCTTCTACAT CTTTACTTCC CCTGCACATT GGCAGGACTC TATTCCTCTA TTTCTCTCTA GTGCTAGAGC AGAAAGGGAC CTTGATTTGA TATCAGGAAA ATCTATTTCT GAACCATAAG CTATGATAGC TGATTTAAAA AATTGACTAT CATGACATGA TAATGATCAT AATGGTAATA CATATTGATA GGGTTGCCGT GAAAGTAATA ATATATCTAA GAGTTGTGAC AATATATGAT ACGCCTAGAC TCTCAGAAAA TGCTAATTCC AATCCCAATT GCTCTTTGCA TAAAGTTCTG TCCTAGGGTC TGTTCTTTTC CCACATCTAC CCTCCTTGGA TCTCTCTTCT GTCTTTTTCA TGTGGTTCAG AGGAGGAGAG AGATCCAGGT CAATGTTTTT CAAATTACAA GGAATTATCA TTTAAATGGG GAAGAAGCTC AAGTTTTGAC GTGTAGTGGA ATTGGAGTGG AGTGGAGTGG AATGGAAACT AACAGGAAGA CACTGCACAT GGTTAAGATA AAGATTGTTT CCTGAAACCT TTAATTTGTG CTTACATACT CACACATACA TATGTGCATG CACTGGGACT CTGCAATATG CATTTCTGAC TATGGAACAT AGCCATAAAA GTCTTTGCAC TGAACGTTCA GTGGGCCTTT CACAAGCTGC CCTAATTGGG AAAGAAAAAC ATGGTCCCTC CATTTCCTGC CCCCAACTCC AGAAAAGTCA CCATAGTTGA GGGTACATCT GAGAAGCCAG CACTTGGGAG TTCAGGGCTC AAGTTCCTTT CTAGAAAAAC ACTGGGTGAT TCTAGGGGAA CTTCCGATCA GAAACAGCCA ATTCAGAGTG AGAGAAGAAA ACGTGACCAT GCAGTTCCTG TGGTTACCAG CCTTGCCCCT CTCTTGCCTT CTGGGAGTTA TAAAACCCAA GACTGGAAAG GAAAACCAGC ATTTGCTCAG GCAGCCTCTC TGGGAAGATG CTGCTTCTTC CTCTCCCCCT GCTGCTCTTT CTCTTGTGCT CCAGAGCTGA AGCTGGTGAG TATCAGGGTT CTTCCCTCTG AAATCTGCAG TATCAGCTCC TGAAACAAAG ATGTTTAGTC TGAAATAGCT GACTCCTAAA CAGGGTTCCA AGATCTCTCT TCAAGAGTCC CACAGAGGAA ATTTCCACTT GGGATGTGTG CCACCCCACC CCCACCCCCA CCCACTGCCA TTCTCTACAG CCTAGGACAC CCCCAGGAAC AAGGAATTTC ACCTCAATTG TAGAAAAGCC CAGAGCAAGT GGAAGGAAAA GGGGTATCCC CAGGAAAACA GACATGTCCT CTTAATCTTC TGAGCATCAG GGCTACCCAT TACTTTGTGA CTTTCTCACT CTGTGACCAT GCTCAAGAGC TATGGAGAAA TCTAAAACAG GAACCTGGAC AGTGGGTCCT ACACAGAGAC AGAGGAGAGT GGGCCAGGGC AAGGTGGGAG TGGGAGAAGT CTGAGATGAA AACATCAGAA TGGAGCAGAG GCAAGAATGA GATTTCACCT GGGAGGTTAT GGGTGGGGAA AGATACGAAA TACAGGAGAC AGGAGAGGGA AGATGGGCGG AACACAGGGT GAGAATGAGA TTCCAGGGAA GCCTAGCTCA GCTTTAACCC AATTTGTCCA TTCATTGGAG AGAGTATCTA TGGCCGTGTT CAAACCCTGG GGTGCTCTGT TCCAGGGGAG ATCATCGGGG GCACAGAATG CAAGCCACAT TCCCGCCCCT ACATGGCCTA CCTGGAAATT GTAACTTCCA ACGGTCCCTC AAAATTTTGT GGTGGTTTCC TTATAAGACG GAACTTTGTG CTGACGGCTG CTCATTGTGC AGGAAGGTGA GACAACAGGG TCTATTTATC TCCAAATGGG AGATGAACAA CCAGAGTAGC ATCCAGGAAT ACACCTGCAC TGGGGACTGA AGAGGGGGTC CTGGGTCTTG TCAACTTTCA GGAGAGGGAA GACTTTGGGC TGAAAGACTT TAGTCTGTGT TTGAATAGTT CCTTGAGCCT CAGTCACTGA GCTAAGCTCC CTTCGGAGGA AAAGGAGGTC CTGTCCGAAG GTCCCTCTTG TTGCAGTAGC ACCCCTCACC CCTACCCAAC TCAAGACACA CGGCTCACTT TTCAGGGCCC CACCCAGTCT CAGGGCCACT TCCTCTATGG CCTTTTCAAG AACACTGGCT CTAGTTCTCA GGGTCCTGAA CCCATCATTT TATGGGAGCA GAGAACAGGT CTACATAAGA CCCCCACTTT CCCGTTTTAA CTGATATCTC CTGCTTCAGG GGCTGGCCCT CATGCAGGGT TCCCTGAATT AGGAAGTGTG AACCCTGTCC CCTGAGTCCT CCCTGGCCTG TTCAGTCCCC AGCAATTCCA GGGGTCGTAG AAATTGTGTC TGTTTCCTGA GAAAGCTCTT TCATGAGTTA AGCCTGAGCC CTCAAATGCC ACAAGTGGCC CATGAAAAGG GAGATGGGTA GAGTCCGGCN ACCCAGTGAC AGAGTTTAGT CCTCTTTTCT CAGAATGAGC TCACCTCAGA AGAAACCCCA AGCCATCACT GTCGCCTCCT TTTCCTTCCT TCTTCCTCAC AGCAGGTCTA TAACAGTCAC CCTTGGAGCC CATAACATAA CAGAGGAAGA AGACACATGG CAGAAGCTTG AGGTTATAAA GCAATTCCGT CATCCAAAAT ATAACACTTC TACTCTTCAC CACGATATCA TGTTACTAAA GGTGACAACA CCTCTCTTCT CCCTTTCCAC TTCCCATTCT CCTAAGCTTC TCCTTCAGGT CCTCATTGCC CTGAATTTTT CTTAGGACTT GGCTATAACA TGAAGCTACT CACCCTGTCC CTCCCTGATC ACCTCCAACT GTCCAGAGCC CATTTCGAGG ACTGACAGTC CTTCATTCCC TTCACAGTTG AAGGAGAAAG CCAGCCTGAC CCTGGCTGTG GGGACACTCC CCTTCCCATC ACAATTCAAC TTTGTCCCAC CTGGGAGAAT GTGCCGGGTG GCTGGCTGGG GAAGAACAGG TGTGTTGAAG CCGGGCTCAG ACACTCTGCA AGAGGTGAAG CTGAGACTCA TGGATCCCCA GGCCTGCAGC CACTTCAGAG ACTTTGACCA CAATCTTCAG CTGTGTGTGG GCAATCCCAG GAAGACAAAA TCTGCATTTA AGGTGATCCT CCAACTAGGT TTCCTCTCCA AAACTCACTG TTCAGGGACC TGAATGCTCT TAGAAGGAGA TGGGGTCAGC AGGTTGTCAG TCAGGTGACA GGGTGAGCAT CACAGGAATT GCTGTCCTCC CGTGGTCCAA GACAGCCTCT GACCATCCAT TCCAGTCTAC TGCACTGGGG GCATGGGGTG ACTGTGGAGA ATGTGGATGA CGGTCCCAAG AAAGGAAGAA GGGGCATCAG AACTAGATGT ATAAGTGAGG AGCTCCACCT CCTGGGTCTG ACTTTAGGTC TCACTGTGAC TCCAAGCTGG CTGGCAGACA GGAGTGGAGG ACTTCCCGGG CTCACCTTCT TCTCTCTCTC CTCCCCCTAC AGGGAGACTC TGGGGGCCCT CTTCTGTGTG CTGGGGTGGC CCAGGGCATC GTATCCTATG GACGGTCGGA TGCAAAGCCC CCTGCTGTCT TCACCCGAAT CTCCCATTAC CGGCCCTGGA TCAACCAGAT CCTGCAGGCA AATTAATCCT GGATCCTGAG CCAGCCTGAA GGGAAGCTGG AACTGGACCT TAGCAGCAAA GTGTGTGCAA CTCATTCTGG TTCTACCCTT GGTTCCCTCA GCCACAACCC TAAGCCTCCA AGAGGTCTCC TACAGGTAAC AGAACTTTCA ATAAACTTCA GTGAAGACAC AGCTTCTAGT CGTGAGTGTG TGTCCCTCTC TGCTGCTCTC TTCTCCTGCA CATGTGACCT GATTCCCAGC CCAAGCACCA AGGA-3' (FRAG. NO:) (SEQ. ID NO:2467) 5 -GGBGCBCBBG-3' (FRAG. NO:1888) (SEQ. ID NO:1899) 5 -GBBGCBGC-3' (FRAG. NO:1889) (SEQ. ID NO:1900) 5 -GGGGCBBGG CG-3' (FRAG. NO:1890) (SEQ. ID NO:1901) 5'-CGTTTTCTTCTCTC-3' (FRAG. NO:1369)(SEQ. ID NO:1379) 5 -GCTGGTTTTCCTTTCC-3' (FRAG. NO:1370)(SEQ. DO NO:1380) EPI-109 21 1

5' TGGCAGTGGGTGGGGGTGGGGGTGGGGTGGC 3 (FRAG. NO:1371)(SEQ. ID NO:1381)

5 TTCCTTGTTCCTGGGGGTGTCCT-3' (FRAG. NO:1372)(SEQ. ID NO:1382)

5 -CTTGCTCTCGGCTTTTCT-3' (FRAG NO 1373)(SEQ ID NO 1383)

5 CCCCTTTTCCTTCC 3' (FRAG NO 1374)(SEQ ID NO 1384)

5'-TGTCTGTTTTCCTGGGG-3' (FRAG NO 1375)(SEQ ID NO 1385)

5'-CTCTCCTCTGTCTCTGTGT 3' (FRAG NO 1376)(SEQ ID NO 1386)

5 CCTTGCCCTGGCCC-3' (FRAG NO 1377)(SEQ ID NO 1387)

5' TCTTCCCTCTCCTGTCTCCTGT-3' (FRAG NO 1378)(SEQ ID NO 1388)

5' CCCTGTGTTCCGCCC-3' (FRAG NO 1379)(SEQ ID NO 1389)

5' GTCTTCCCTCTCCTG-3' (FRAG NO 1380)(SEQ ID NO 1390)

5 ' - ACCTCCTTTTCCTCCG -3 ' (FRAG NO 1381)(SEQ ID NO 1391)

5'-CTGGGTGGGGCCCTG-3 (FRAG NO 1382XSEQ ID NO 1392)

5 -CCTGTTCTCTGCTCCC-3' (FRAG NO 1383)(SEQ ID NO 1393)

S'-TGGCTTGGGGTTTCTTCTG ' (FRAG NO 1384)(SEQ ID NO 1394)

5'-TGTGTCTTCTTCCTCTGTT-3' (FRAG NO 1385)(SEQ ID NO 1395)

5'-GGCTGGCTTTCTCCTTC 3' (FRAG NO 1386)(SEQ ID NO 1396)

5 -TTTTGTCTTCCTGGG-3 (FRAG NO 1387)(SEQ ID NO 1397)

5'-TGCCCCTTCTTCCTTTCTTGGG-3' (FRAG NO 1388)(SEQ ID NO 1398)

5'-TCCTTGGTGCTTGGGCTGGG-3' (FRAG NO 1389)(SEQ ID NO 1399)

5'-GGBGCTGBTB CTGCBGATTT CBGBGGGBBG BBCCCTGBTB CTCBCCBGCT TCBGCTCTGG BGCBCBBGBG BBBGBGCBGC

BGGGGGBGBG GBBGBBGCBG CBTCTTCCCB GBGBGGCTGC CTGBGCBBBT GCTGGTTTTC CTTTCCBGTC TTGGGTTTTB

TBBCTCCCBG BBGGCBBGBG BGGGGCBBGG-3 (FRAG. NO:1891) (SEQ. ID NO:1902)

Endothelial Nitric Oxide Svnthase Nucleic Acids and Antisense Oligonucleotide Fragments

5 -GCGTCTTGGG GTGCBGGGCC CBTCCTGCTG CGCCTGGGCG CTGCTGTGCG TCCGTCTGCT GGGGGGCCGG GGTGGCTGGG

CCCTGCTTGC CGCACGACCC CGGGCCGACC CGAGGCTCGG GGGGCTGTGT TCTGGCGCTG GTGGGCTTGG GCCCCTCTGG

GGGCTGGGTT TCCTGCTGCG CCTGGGCGCT GGCGTCTTGG GGTGCGGGGC CGGGGGGCCG GGGGGCCGCT GTTCGTGGGC

CTGGGGGTGC CTGTGGCTGC CGGTTGCCCC GGTTGGTGGC GCCGTCCTGC TGCCGGTCGT TGGCTGGGTC CCCCCGCCCG

TTTCCTGGGG TCCGCGTGGG GTGCTCCGGT TCCTCGTGCC GCTGCTGCCT TGTCTTTCCG GCCGTGGCGG CGTGGTGGTC

CGCCCCCCCT GGCCTTCTGC TCGGGGTCTG GCTGGTTCCC GGTGCCCTTG GCGGCGGTCT TCTTCCTGGT GGCTCTGGGC

CCGGCCGGTC TCGGGCGTCT CGTGTTCGCT CTTGTGCTGT TCCGGCCGCT CCTTCCTCTT CCGCCGCCGC CGCTCCCCGC

CCGCTCGTCG CCCTGGCCCG GCCTCCTCCT GGCCGCTGTC TCGGGCGGCG GCCTTGGCGC TCCGTTTGGG GCTGCCTCTG

GCGCTTCCGG CCCTCGGCCT GGGCGCTCTC TTCCGCCTGT GCTGGTGGCC CTCGTGGGCC CCTCCTGGCC TCCGGTGTCC

TGTGGTCCCC CGGCTCGTGG CCGGGCCGGT TGGGCGGGCG TGGGCGCCGG CGGGTCCTCC GGGCTCCCCT TCTCCGCCGG

GGGTCCCGCG CTCCTGCTGT TCCCTGGGCT CTTCTGCCTC TCTCCTGGGT GGGTGCTGGG TGCCGGGGTC TCCGGGCTTG

CCCCGCGCTG CTGGGCGTTC TGCGGTCTTG GGGTTGTCTG TGGCCCCGCT CGTGTCGCCC TCCGTCGCCC GTCGCCGGCC

TCGTCCCCTC CTGGGTGCGC GGCGGGCTGG TCCTGGCGTT TTGCTCCTTC CTGGGCGTCT TGGGGTGCBG GGCCCBTCCT

GCTGCGCCTG GGCGCTGCTG TGCGTCCGTC TGCTGGGGGG CCGGGGTGGC TGGGCCCTGC TTGCCGCACG ACCCCGGGCC

GACCCGAGGC TCGGGGGGCT GTGTTCTGGC GCTGGTGGGC TTGGGCCCCT CTGGGGGCTG GGTTTCCTGC TGCGCCTGGG

CGCTGGCGTC TTGGGGTGCG GGGCCGGGGG GCCGGGGGGC CGCTGTTCGT GGGCCTGGGG GTGCCTGTGG CTGCCGGTTG

CCCCGGTTGG TGGCGCCGTC CTGCTGCCGG TCGTTGGCTG GGTCCCCCCG CCCGTTTCCT GGGGTCCGCG TGGGGTGCTC

CGGTTCCTCG TGCCGCTGCT GCCTTGTCTT TCCGGCCGTG GCGGCGTGGT GGTCCGCCCC CCCTGGCCTT CTGCTCGGGG

TCTGGCTGGT TGCCGGTGCC CTTGGCGGCG GTCTTCTTCC TGGTGGCTCT GGGCCCGGCC GGTCTCGGGC GTCTCGTGTT

CGCTCTTGTG CTGTTCCGGC CGCTCCTTCC TCTTCCGCCG CCGCCGCTCC CCGCCCGCTC GTCGCCCTGG CCCGGCCTCC

TCCTGGCCGC TGTCTCGGGC GGCGGCCTTG GCGCTCCGTT TGGGGCTGCC TCTGGCGCTT CCGGCCCTCG GCCTGGGCGC

TCTCTTCCGC CTGTGCTGGT GGCCCTCGTG GGCCCCTCCT GGCCTCCGGT GTCCTGTGGT CCCCCGGCTG GTGGCCGGGC

CGGTTGGGCG GGCGTGGGCG CCGGCGGGTC CTCCGGGCTG CCCTTCTCCG CCGGGGGTCC CGCGCTCCTG CTGTTCCCTG

GGCTCTTCTG CCTCTCTCCT GGGTGGGTGC TGGGTGCCGG GGTCTCCGGG CTTGCCCCGC GCTGCTGGGC GTTCTGCGGT

CTTGGGGTTG TCTGTGGCCC CGCTCGTGTC GCCCTCCGTC GCCCGTCGCC GGCCTCGTCC CCTCCTGGGT GCGCGGCGGG

CTGGTCCTGG CGTTTTGCTC CTTCCTCG-S' (FRAG. NO:1892) (SEQ. U NO: 1903)

5 -GCGGGGCCG-3 (FRAG. NO:1893) (SEQ. ID NO: 1904)

5 -CGGGGGGC-3' (FRAG. NO:1894) (SEQ. ID NO: 1905)

5 -GCGCGGCGGGC-3' (FRAG. NO:1895) (SEQ. ID NO: 1906)

S'-CTGTGCGTCCGTCTGCTGG (FRAG. NO:1390)(SEQ. ID NO:1400)

GGGGCCGGGGTGGCTGGGCCCTGCTTGCCGC (FRAG NO 1391)(SEQ ID NO 1401)

ACGACCCCGGGCCGACCCGAG (FRAG NO 1392)(SEQ ID NO 1402)

GCTCGGGGGGCTGTGTTCTGGCGCTGGTGGG (FRAG NO 1393)(SEQ ID NO 1403)

CTTGGGCCCCTCTGGGGGCTGGGTT (FRAG NO 1394)(SEQ ID NO 1404)

TCCTGCTGCGCCTGGGCGCTG (FRAG NO 1395)(SEQ ID NO 1405)

GCGTCTTGGGGTGC (FRAG NO 1396)(SEQ ID NO 1406)

GGGGCCGGGGGGCCGGGGG (FRAG NO 1397)(SEQ ID NO 1407)

GCCGCTGTTCGTGGGCCTGGG (FRAG NO 1398)(SEQ ID NO 1408)

GGTGCCTGTGGCTGCC (FRAG NO 1399)(SEQ ID NO 1409)

GGTTGCCCCGGTTGGTGGC (FRAG NO 1400)(SEQ ID NO 1410)

GCCGTCCTGCTGCCGGT (FRAG NO 1401XSEQ ID NO 1411)

CGTTGGCTGGGTCCCCCCGC (FRAG NO 1402)(SEQ ID NO 1412)

CCGTTTCCTGGGGTCC (FRAG NO 1403)(SEQ ID NO 1413)

GCGTGGGGTGCTCC (FRAG NO 1404)(SEQ ID NO 1414)

GGTTCCTCGTGCCG (FRAG NO 1405)(SEQ ID NO 1415)

CTGCTGCCTTGTCTTTCC (FRAG NO 1406)(SEQ ID NO 1416) EPI-109 212

GGCCGTGGCGGCGTGGTGGTCC (FRAG NO 1407)(SEQ ID NO 1417)

GCCCCCCCTGGCCTTCTGCTC (FRAG NO 1408)(SEQ ID NO 1418)

GGGGTCTGGCTGGT (FRAG NO 1409)(SEQ ID NO 1419)

TGCCGGTGCCCTTGGCGGC (FRAG NO 1410)(SEQ ID NO 1420)

GGTCTTCTTCCTGGTG (FRAG NO 1411)(SEQ ID NO 1421)

GCTCTGGGCCCGGCCGGTCTCGG (FRAG NO 1412)(SEQ ID NO 1422)

GCGTCTCGTGTTCG (FRAG NO 1413)(SEQ ID NO 1423)

CTCTTGTGCTGTTCCGGCCG (FRAG NO 1414)(SEQ ID NO 1424)

CTCCTTCCTCTTCCGCCGCC (FRAG NO 1415)(SEQ ID NO 1425)

GCCGCTCCCCGCCC (FRAG NO 1416)(SEQ ID NO 1426)

GCTCGTCGCCCTGGCCC (FRAG NO 1417)(SEQ ID NO 1427)

GGCCTCCTCCTGGCCGC (FRAG NO 1418)(SEQ ID NO 1428)

TGTCTCGGGCGGCGGCCTTGGC (FRAG NO 1419)(SEQ ID NO 1429)

GCTCCGTTTGGGGCTG (FRAG NO 1420)(SEQ ID NO 1430)

CCTCTGGCGCTTCC (FRAG NO 1421)(SEQ ID NO 1431)

GGCCCTCGGCCTGGGCGCTC (FRAG NO 1422)(SEQ ID NO 1432)

TCTTCCGCCTGTGC (FRAG NO 1423)(SEQ ID NO 1433)

TGGTGGCCCTCGTGG (FRAG NO 1424)(SEQ ID NO 1434)

GCCCCTCCTGGCCTCCGGTGTCC (FRAG NO 1425)(SEQ ID NO 1435)

TGTGGTCCCCCGGCTGGT (FRAG NO 1426)(SEQ ID NO 1436)

GGCCGGGCCGGTTGGGCGGGC (FRAG NO 1427)(SEQ ID NO 1437)

GTGGGCGCCGGCGGGTCCTCC (FRAG NO 1428)(SEQ ID NO 1438)

GGGCTGCCCTTCTCC (FRAG NO 1429)(SEQ ID NO 1439)

GCCGGGGGTCCCGC (FRAG NO 1430XSEQ ID NO 1440)

GCTCCTGCTGTTCCCTGGGCTCTTCTGCC (FRAG NO 1431)(SEQ ID NO 1441)

TCTCTCCTGGGTGGGTGCTGGGTGCCG (FRAG NO 1432)(SEQ ID NO 1442)

GGGTCTCCGGGCTTG (FRAG NO 1433)(SEQ ID NO 1443)

CCCCGCGCTGCTGGGCGTTCTGC (FRAG NO 1434)(SEQ ID NO 1444)

GGTCTTGGGGTTGTC (FRAG NO 1435)(SEQ ID NO 1445)

TGTGGCCCCGCTCG (FRAG NO 1436)(SEQ ID NO 1446)

TGTCGCCCTCCGTCGCC (FRAG NO 1437)(SEQ ID NO 1447)

CGTCGCCGGCCTCGTCC (FRAG NO 1438)(SEQ ID NO 1448)

CCTCCTGGGTGCGC (FRAG NO 1439)(SEQ ID NO 14₄9)

GGCGGGCTGGTCCT (FRAG NO 14₄0)(SEQ ID NO 1450)

GGCGTTTTGCTCCTTCCTGG (FRAG NO 1441)(SEQ ID NO 1451)

5'-GCGTCTTGGGGTGCBGGGCCCBTCCTGCTGCGCCTGGGCGCTG 3 (FRAG. NO:1896) (SEQ. ID NO: 1907)

Inducible Nitric Oxide Svnthase Nucleic Acids and Antisense Oligonucleotide Fragments

5 -CTGCCCCBGT TTTTGBTCCT CBCBTGCCGT GGGGBGGBCB BTGGCTGCCT CCCCGGGGTT TCTGCTGCTT GCTGCTTCTT

TCCCGTCTCC CTTCTTTCCC GTCTCCTTTT TGCCTCTTTG GGTTCCTGTT GTTTCTGGCC TGCTTGGTGG CGGCTTGTGC

GTTTCCTCTC TCTTCTCTTG GGTCTCCGCT TCTCGTCCTG CCTTTTCCTG TCTCTGTCGC GCCGTTCCTC CTCCGGCGTC

CTCCTGCCCT GTGCTGTTTG CCTCGGGTGG TGCGGGTCCC GGTGCTCCCC CGGCGGGCCG GCTGGTTGCC TGGGCCTGTC

TGGTGGGGTG TGGGGCCGCT GGGTTGGGGG TGTGGTGGGC TCTTCTGTGG CCTGTGGGGC TGTTGGTGTC TCTGTGGGCG

TGTGCTGGGT CTTGGGGCTT CCTCCCTTGT GCTGGGTGCG GCCTCCCCGC CCCCCTTCTG GGCCGGTGGC CTGGCTCCTT

GTGGGCGCTT CTGGCTCTTG CCCTGTCCTT CTTCGCCTCG TGGCTGCTGG GCTGC CATATGTATG GGAATACTGT

ATTTCAGGCA TTATAAGGAA TGAAATTATA GGCCGGGCAT TGTGGCTAAC CCTTGTAATC CTAGCACTTT

GAGAGGCTGA AGTGGGCAGA TCACTTGAGC TTCAGAGTTC GAGACCAGCA TGGACAACAT GGTGAAACCC

AGTCTCTACC AAAAACACAA AAATATTAGC TGGGTGTGGT GGTGCATGCC TGTAGTCCCA GCTACTCAGG

AGGCTGAGGT GGGAGGATCG CTTGAGCCTG GGAGGCAGAA GTTGCAATGA GCAGAGATCG TGCCACTCCG

CTCCAGTCTT GGTGACAGAA TGAGACTCCA TCTCAAAAAT AAATAAATAA ATAAATAAAA TAAATGAAAT

GAAATTATAA GAAATTACCA CTTTTTCATG TAAGAAGTGA TCATTTCCAT TATAAGGGAA GGAATTTAAT

CCTACCTGCC ATTCCACCAA AGCTTACCTA GTGCTAAAGG ATGAGGTGTT AGTAAGACCA ACATCTCAGA

GGCCTCTCTG TGCCAATAGC CTTCCTTCCT TTCCCTTCCA AAAACCTCAA GTGACTAGTT CAGAGGCCTG

TCTGGAATAA TGGCATCATC TAATATCACT GGCCTTCTGG AACCTGGGCA TTTTCCAGTG TGTTCCATAC

TGTCAATATT CCCCCAGCTT CCTGGACTCC TGTCACAAGC TGGAAAAGTG AGAGGATGGA CAGGGATTAA

CCAGAGAGCT CCCTGCTGAG GAAAAAATCT CCCAGATGCT GAAAGTGAGG CCATGTGGCT TGGCCAAATA

AAACCTGGCT CCGTGGTGCC TCTGTCTTAG CAGCCACCCT GCTGATGAAC TGCCACCTTG GACTTGGGAC

CAGAAAGAGG TGGGTTGGGT GAAGAGGCAC CACACAGAGT GATGTAACAG CAAGATCAGG TCACCCACAG

GCCCTGGCAG TCACAGTCAT AAATTAGCTA ACTGTACACA AGCTGGGGAC ACTCCCTTTG GAAACCAAAA

AAAAAAAAAA AAAAAAGAGA CCTTTATGCA AAAACAACTC TCTGGATGGC ATGGGGTGAG TATAAATACT

TCTTGGCTGC CAGTGTGTTC ATAACTTTGT AGCGAGTCGA AAACTGAGGC TCCGGCCGCA GAGAACTCAG

CCTCATTCCT GCTTTAAAAT CTCTCGGCCA CCTTTGATGA GGGGACTGGG CAGTTCTAGA CAGTCCCGAA

GTTCTCAAGG CACAGGTCTC TTCCTGGTTT GACTGTCCTT ACCCCGGGGA GGCAGTGCAG CCAGCTGCAA

GGTGAGTTGC CATATGTATG GGAATACTGT ATTTCAGGCA TTATAAGGAA TGAAATTATA GGCCGGGCAT

TGTGGCTAAC CCTTGTAATC CTAGCACTTT GAGAGGCTGA AGTGGGCAGA TCACTTGAGC TTCAGAGTTC

GAGACCAGCA TGGACAACAT GGTGAAACCC AGTCTCTACC AAAAACACAA AAATATTAGC TGGGTGTGGT

GGTGCATGCC TGTAGTCCCA GCTACTCAGG AGGCTGAGGT GGGAGGATCG CTTGAGCCTG GGAGGCAGAA

GTTGCAATGA GCAGAGATCG TGCCACTCCG CTCCAGTCTT GGTGACAGAA TGAGACTCCA TCTCAAAAAT

AAATAAATAA ATAAATAAAA TAAATGAAAT GAAATTATAA GAAATTACCA CTTTTTCATG TAAGAAGTGA

TCATTTCCAT TATAAGGGAA GGAATTTAAT CCTACCTGCC ATTCCACCAA AGCTTACCTA GTGCTAAAGG EPI-109 213

ATGAGGTGTT AGTAAGACCA ACATCTCAGA GGCCTCTCTG TGCCAATAGC CTTCCTTCCT TTCCCTTCCA AAAACCTCAA GTGACTAGTT CAGAGGCCTG TCTGGAATAA TGGCATCATC TAATATCACT GGCCTTCTGG AACCTGGGCA TTTTCCAGTG TGTTCCATAC TGTCAATATT CCCCCAGCTT CCTGGACTCC TGTCACAAGC TGGAAAAGTG AGAGGATGGA CAGGGATTAA CCAGAGAGCT CCCTGCTGAG GAAAAAATCT CCCAGATGCT GAAAGTGAGG CCATGTGGCT TGGCCAAATA AAACCTGGCT CCGTGGTGCC TCTGTCTTAG CAGCCACCCT GCTGATGAAC TGCCACCTTG GACTTGGGAC CAGAAAGAGG TGGGTTGGGT GAAGAGGCAC CACACAGAGT GATGTAACAG CAAGATCAGG TCACCCACAG GCCCTGGCAG TCACAGTCAT AAATTAGCTA ACTGTACACA AGCTGGGGAC ACTCCCTTTG GAAACCAAAA AAAAAAAAAA AAAAAAGAGA CCTTTATGCA AAAACAACTC TCTGGATGGC ATGGGGTGAG TATAAATACT TCTTGGCTGC CAGTGTGTTC ATAACTTTGT AGCGAGTCGA AAACTGAGGC TCCGGCCGCA GAGAACTCAG CCTCATTCCT GCTTTAAAAT CTCTCGGCCA CCTTTGATGA GGGGACTGGG CAGTTCTAGA CAGTCCCGAA GTTCTCAAGG CACAGGTCTC TTCCTGGTTT GACTGTCCTT ACCCCGGGGA GGCAGTGCAG CCAGCTGCAA GGTGAGTTGC C-3' (FRAG. NO:_)(SEQ. ED NO: 2506) 5'-CTGCTTTAAA ATCTCTCGGC CACCTTTGAT GAGGGGACTG GGCAGTTCTA GACAGTCCCG AAGTTCTCAA GGCACAGGTC TCTTCCTGGT TTGACTGTCC TTACCCCGGG GAGGCAGTGC AGCCAGCTGC AAGCCCCACA GTGAAGAACA TCTGAGCTCA AATCCAGATA AGTGACATAA GTGACCTGCT TTGTAAAGCC ATAGAGATGG CCTGTCCTTG GAAATTTCTG TTCAAGACCA AATTCCACCA GTATGCAATG AATGGGGAAA AAGACATCAA CAACAATGTG GAGAAAGCCC CCTGTGCCAC CTCCAGTCCA GTGACACAGG ATGACCTTCA GTATCACAAC CTCAGCAAGC AGCAGAATGA GTCCCCGCAG CCCCTCGTGG AGACGGGAAA GAAGTCTCCA GAATCTCTGG TCAAGCTGGA TGCAACCCCA TTGTCCTCCC CACGGCATGT GAGGATCAAA AACTGGGGCA GCGGGATGAC TTTCCAAGAC ACACTTCACC ATAAGGCCAA AGGGATTTTA ACTTGCAGGT CCAAATCTTG CCTGGGGTCC ATTATGACTC CCAAAAGTTT GACCAGAGGA CCCAGGGACA AGCCTACCCC TCCAGATGAG CTTCTACCTC AAGCTATCGA ATTTGTCAAC CAATATTACG GCTCCTTCAA AGAGGCAAAA ATAGAGGAAC ATCTGGCCAG GGTGGAAGCG GTAACAAAGG AGATAGAAAC AACAGGAACC TACCAACTGA CGGGAGATGA GCTCATCTTC GCCACCAAGC AGGCCTGGCG CAATGCCCCA CGCTGCATTG GGAGGATCCA GTGGTCCAAC CTGCAGGTCT TCGATGCCCG CAGCTGTTCC ACTGCCCGGG AAATGTTTGA ACACATCTGC AGACACGTGC GTTACTCCAC CAACAATGGC AACATCAGGT CGGCCATCAC CGTGTTCCCC CAGCGGAGTG ATGGCAAGCA CGACTTCCGG GTGTGGAATG CTCAGCTCAT CCGCTATGCT GGCTACCAGA TGCCAGATGG CAGCATCAGA GGGGACCCTG CCAACGTGGA ATTCACTCAG CTGTGCATCG ACCTGGGCTG GAAGCCCAAG TACGGCCGCT TCGATGTGGT CCCCCTGGTC CTGCAGGCCA ATGGCCGTGA CCCTGAGCTC TTCGAAATCC CACCTGACCT TGTGCTTGAG GTGGCCATGG AACATCCCAA ATACGAGTGG TTTCGGGAAC TGGAGCTAAA GTGGTACGCC CTGCCTGCAG TGGCCAACAT GCTGCTTGAG GTGGGCGGCC TGGAGTTCCC AGGGTGCCCC TTCAATGGCT GGTACATGGG CACAGAGATC GGAGTCCGGG ACTTCTGTGA CGTCCAGCGC TACAACATCC TGGAGGAAGT GGGCAGGAGA ATGGGCCTGG AAACGCACAA GCTGGCCTCG CTCTGGAAAG ACCAGGCTGT CGTTGAGATC AACATTGCTG TGATCCATAG TTTTCAGAAG CAGAATGTGA CCATCATGGA CCACCACTCG GCTGCAGAAT CCTTCATGAA GTACATGCAG AATGAATACC GGTCCCGTGG GGGCTGCCCG GCAGACTGGA TTTGGCTGGT CCCTCCCATG TCTGGGAGCA TCACCCCCGT GTTTCACCAG GAGATGCTGA ACTACGTCCT GTCCCCTTTC TACTACTATC AGGTAGAGGC CTGGAAAACC CATGTCTGGC AGGACGAGAA GCGGAGACCC AAGAGAAGAG AGATTCCATT GAAAGTCTTG GTCAAAGCTG TGCTCTTTGC CTGTATGCTG ATGCGCAAGA CAATGGCGTC CCGAGTCAGA GTCACCATCC TCTTTGCGAC AGAGACAGGA AAATCAGAGG CGCTGGCCTG GGACCTGGGG GCCTTATTCA GCTGTGCCTT CAACCCCAAG GTTGTCTGCA TGGATAAGTA CAGGCTGAGC TGCCTGGAGG AGGAACGGCT GCTGTTGGTG GTGACCAGTA CGTTTCGCAA TGGAGACTGC CCTGGCAATG GAGAGAAACT GAAGAAATCG CTCTTCATGC TGAAAGAGCT CAACAACAAA TTCAGGTACG CTGTGTTTGG CCTCGGCTCC AGCATGTACC CTCGGTTCTG CGCCTTTGCT CATGACATTG ATCAGAAGCT GTCCCACCTG GGGGCCTCTC AGCTCACCCC GATGGGAGAA GGGGATGAGC TCAGTGGGCA GGAGGACGCC TTCCGCAGCT GGGCCGTGCA AACCTTCAAG GCAGCCTGTG AGACGTTTGA TGTCCGAGGC AAACAGCACA TTCAGATCCC CAAGCTCTAC ACCTCCAATG TGACCTGGGA CCCGCACCAC TACAGGCTCG TGCAGGACTC ACAGCCTTTG GACCTCAGCA AAGCCCTCAG CAGCATGCAT GCCAAGAACG TGTTCACCAT GAGGCTCAAA TCTCGGCAGA ATCTACAAAG TCCGACATCC AGCCGTGCCA CCATCCTGGT GGAACTCTCC TGTGAGGATG GCCAAGGCCT GAACTACCTG CCGGGGGAGC ACCTTGGGGT TTGCCCAGGC AACCAGCCGG CCCTGGTCCA AGGCATCCTG GAGCGAGTGG TGGATGGCCC CACACCCCAC CAGACAGTGC GCCTGGAGGA CCTGGATGAG AGTGGCAGCT ACTGGGTCAG TGACAAGAGG CTGCCCCCCT GCTCACTCAG CCAGGCCCTC ACCTACTCCC CGGACATCAC CACACCCCCA ACCCAGCTGC TGCTCCAAAA GCTGGCCCAG GTGGCCACAG AAGAGCCTGA GAGACAGAGG CTGGAGGCCC TGTGCCAGCC CTCAGAGTAC AGCAAGTGGA AGTTCACCAA CAGCCCCACA TTCCTGGAGG TGCTAGAGGA GTTCCCGTCC CTGCGGGTGT CTGCTGGCTT CCTGCTTTCC CAGCTCCCCA TTCTGAAGCC CAGGTTCTAC TCCATCAGCT CCTCCCGGGA TCACACGCCC ACGGAGATCC ACCTGACTGT GGCCGTGGTC ACCTACCACA CCGGAGATGG CCAGGGTCCC CTGCACCACG GTGTCTGCAG CACATGGCTC AACAGCCTGA AGCCCCAAGA CCCAGTGCCC TGCTTTGTGC GGAATGCCAG CGCCTTCCAC CTCCCCGAGG ATCCCTCCCA TCCTTGCATC CTCATCGGGC CTGGCACAGG CATCGTGCCC TTCCGCAGTT TCTGGCAGCA ACGGCTCCAT GACTCCCAGC ACAAGGGAGT GCGGGGAGGC CGCATGACCT TGGTGTTTGG GTGCCGCCGC CCAGATGAGG ACCACATCTA CCAGGAGGAG ATGCTGGAGA TGGCCCAGAA GGGGGTGCTG CATGCGGTGC ACACAGCCTA TTCCCGCCTG CCTGGCAAGC CCAAGGTCTA TGTTCAGGAC ATCCTGCGGC AGCAGCTGGC CAGCGAGGTG CTCCGTGTGC TCCACAAGGA GCCAGGCCAC CTCTATGTTT GCGGGGATGT GCGCATGGCC CGGGACGTGG CCCACACCCT GAAGCAGCTG GTGGCTGCCA AGCTGAAATT GAATGAGGAG CAGGTCGAGG ACTATTTCTT TCAGCTCAAG AGCCAGAAGC GCTATCACGA AGATATCTTC GGTGCTGTAT TTCCTTACGA GGCGAAGAAG GACAGGGTGG CGGTGCAGCC CAGCAGCCTG GAGATGTCAG CGCTCTGAGG GCCTACAGGA GGGGTTAAAG CTGCCGGCAC AGAACTTAAG GATGGAGCCA GCTCTGCATT ATCTGAGGTC ACAGGGCCTG GGGAGATGGA GGAAAGTGAT ATCCCCCAGC CTCAAGTCTT ATTTCCTCAA CGTTGCTCCC CATCAAGCCC TTTACTTGAC CTCCTAACAA GTAGCACCCT GGATTGATCG GAGCCTCCTC TCTCAAACTG GGGCCTCCCT GGTCCCTTGG AGACAAAATC TTAAATGCCA GGCCTGGCGA GTGGGTGAAA GATGGAACTT GCTGCTGAGT GCACCACTTC AAGTGACCAC CAGGAGGTGC TATCGCACCA CTGTGTATTT AACTGCCTTG TGTACAGTTA TTTATGCCTC TGTATTTAAA AAACTAACAC CCAGTCTGTT CCCCATGGCC ACTTGGGTCT TCCCTGTATG ATTCCTTGAT GGAGATATTT ACATGAATTG CATTTTACTT TAATC GAATTCCCAC

TCTGCTGCCT GCTCCAGCAG ACGGACGCAC AGTAACATGG GCAACTTGAA GAGCGTGGCC CAGGAGCCTG GGCCACCCTG CGGCCTGGGG CTGGGGCTGG GCCTTGGGCT GTGCGGCAAG CAGGGCCCAG CCACCCCGGC CCCTGAGCCC AGCCGGGCCC CAGCATCCCT ACTCCCACCA GCGCCAGAAC ACAGCCCCCC GAGCTCCCCG CTAACCCAGC CCCCAGAGGG GCCCAAGTTC CCTCGTGTGA AGAACTGGGA GGTGGGGAGC ATCACCTATG ACACCCTCAG CGCCCAGGCG CAGCAGGATG GGCCCTGCAC CCCAAGACGC TGCCTGGGCT CCCTGGTATT TCCACGGAAA CTACAGGGCC GGCCCTCCCC CGGCCCCCCG GCCCCTGAGC EPI-109 214

AGCTGCTGAG TCAGGCCCGG GACTTCATCA ACCAGTACTA CAGCTCCATT AAGAGGAGCG GCTCCCAGGC CCACGAACAG CGGCTTCAAG AGGTGGAAGC CGAGGTGGCA GCCACAGGCA CCTACCAGCT TAGGGAGAGC GAGCTGGTGT TCGGGGCTAA GCAGGCCTGG CGCAACGCTC CCCGCTGCGT GGGCCGGATC CAGTGGGGGA AGCTGCAGGT GTTCGATGCC CGGGACTGCA GGTCTGCACA GGAAATGTTC ACCTACATCT GCAACCACAT CAAGTATGCC ACCAACCGGG GCAACCTTCG CTCGGCCATC ACAGTGTTCC CGCAGCGCTG CCCTGGCCGA GGAGACTTCC GAATCTGGAA CAGCCAGCTG GTGCGCTACG CGGGCTACCG GCAGCAGGAC GGCTCTGTGC GGGGGGACCC AGCCAACGTG GAGATCACCG AGCTCTGCAT TCAGCACGGC TGGACCCCAG GAAACGGTCG CTTCGACGTG CTGCCCCTGC TGCTGCAGGC CCCAGATGAG CCCCCAGAAC TCTTCCTTCT GCCCCCCGAG CTGGTCCTTG AGGTGCCCCT GGAGCACCCC ACGCTGGAGT GGTTTGCAGC CCTGGGCCTG CGCTGGTACG CCCTCCCGGC AGTGTCCAAC ATGCTGCTGG AAATTGGGGG CCTGGAGTTC CCCGCAGCCC CCTTCAGTGG CTGGTACATG AGCACTGAGA TCGGCACGAG GAACCTGTGT GACCCTCACC GCTACAACAT CCTGGAGGAT GTGGCTGTCT GCATGGACCT GGATACCCGG ACCACCTCGT CCCTGTGGAA AGACAAGGCA GCAGTGGAAA TCAACGTGGC CGTGCTGCAC AGTTACCAGC TAGCCAAAGT CACCATCGTG GACCACCACG CCGCCACGGC CTCTTTCATG AAGCACCTGG AGAATGAGCA GAAGGCCAGG GGGGGCTGCC CTGCAGACTG GGCCTGGATC GTGCCCCCCA TCTCGGGCAG CCTCACTCCT GTTTTCCATC AGGAGATGGT CAACTATTTC CTGTCCCCGG CCTTCCGCTA CCAGCCAGAC CCCTGGAAGG GGAGTGCCGC CAAGGGCACC GGCATCACCA GGAAGAAGAC CTTTAAAGAA GTGGCCAACG CCGTGAAGAT CTCCGCCTCG CTCATGGGCA CGGTGATGGC GAAGCGAGTG AAGGCGACAA TCCTGTATGG CTCCGAGACC GGCCGGGCCC AGAGCTACGC ACAGCAGCTG GGGAGACTCT TCCGGAAGGC TTTTGATCCC CGGGTCCTGT GTATGGATGA GTATGACGTG GTGTCCCTCG AACACGAGAC GCTGGTGCTG GTGGTAACCA GCACATTTGG GAATGGGGAT CCCCCGGAGA ATGGAGAGAG CTTTGCAGCT GCCCTGATGG AGATGTCCGG CCCCTACAAC AGCTCCCCTC GGCCGGAACA GCACAAGAGT TATAAGATCC GCTTCAACAG CATCTCCTGC TCAGACCCAC TGGTGTCCTC TTGGCGGCGG AAGAGGAAGG AGTCCAGTAA CACAGACAGT GCAGGGGCCC TGGGCACCCT CAGGTTCTGT GTGTTCGGGC TCGGCTCCCG GGCATACCCC CACTTCTGCG CCTTTGCTCG TGCCGTGGAC ACACGGCTGG AGGAACTGGG CGGGGAGCGG CTGCTGCAGC TGGGCCAGGG CGACGAGCTG TGCGGCCAGG AGGAGGCCTT CCGAGGCTGG GCCCAGGCTG CCTTCCAGGC CGCCTGTGAG ACCTTCTGTG TGGGAGAGGA TGCCAAGGCC GCCGCCCGAG ACATCTTCAG CCCCAAACGG AGCTGGAAGC GCCAGAGGTA CCGGCTGAGC GCCCAGGCCG AGGGCCTGCA GTTGCTGCCA GGTCTGATCC ACGTGCACAG GCGGAAGATG TTCCAGGCTA CAATCCGCTC AGTGGAAAAC CTGCAAAGCA GCAAGTCCAC GAGGGCCACC ATCCTGGTGC GCCTGGACAC CGGAGGCCAG GAGGGGCTGC AGTACCAGCC GGGGGACCAC ATAGGTGTCT GCCCGCCCAA CCGGCCCGGC CTTGTGGAGG CGCTGCTGAG CCGCGTGGAG GACCCGCCGG CGCCCACTGA GCCCGTGGCA GTAGAGCAGC TGGAGAAGGG CAGCCCTGGT GGCCCTCCCC CCGGCTGGGT GCGGGACCCC CGGCTGCCCC CGTGCACGCT GCGCCAGGCT CTCACCTTCT TCCTGGACAT CACCTCCCCA CCCAGCCCTC AGCTCTTGCG GCTGCTCAGC ACCTTGGCAG AAGAGCCCAG GGAACAGCAG GAGCTGGAGG CCCTCAGCCA GGATCCCCGA CGCTACGAGG AGTGGAAGTG GTTCCGCTGC CCCACGCTGC TGGAGGTGCT GGAGCAGTTC CCGTCGGTGG CGCTGCCTGC CCCACTGCTC CTCACCCAGC TGCCTCTGCT CCAGCCCCGG TACTACTCAG TCAGCTCGGC ACCCAGCACC CACCCAGGAG AGATCCACCT CACTGTAGCT GTGCTGGCAT ACAGGACTCA GGATGGGCTG GGCCCCCTGC ACTATGGAGT CTGCTCCACG TGGCTAAGCC AGCTCAAGCC CGGAGACCCT GTGCCCTGCT TCATCCGGGG GGCTCCCTCC TTCCGGCTGC CACCCGATCC CAGCTTGCCC TGCATCCTGG TGGGTCCAGG CACTGGCATT GCCCCCTTCC GGGGATTCTG GCAGGAGCGG CTGCATGACA TTGAGAGCAA AGGGCTGCAG CCCACTCCCA TGACTTTGGT GTTCGGCTGC CGATGCTCCC AACTTGACCA TCTCTACCGC GACGAGGTGC AGAACGCCCA GCAGCGCGGG GTGTTTGGCC GAGTCCTCAC CGCCTTCTCC CGGGAACCTG ACAACCCCAA GACCTACGTG CAGGACATCC TGAGGACGGA GCTGGCTGCG GAGGTGCACC GCGTGCTGTG CCTCGAGCGG GGCCACATGT TTGTCTGCGG CGATGTTACC ATGGCAACCA ACGTCCTGCA GACCGTGCAG CGCATCCTGG CGACGGAGGG CGACATGGAG CTGGACGAGG CCGGCGACGT CATCGGCGTG CTGCGGGATC AGCAACGCTA CCACGAAGAC ATTTTCGGGC TCACGCTGCG CACCCAGGAG GTGACAAGCC GCATACGCAC CCAGAGCTTT TCCTTGCAGG AGCGTCAGTT GCGGGGCGCA GTGCCCTGGG CGTTCGACCC TCCCGGCTCA GACACCAACA GCCCCTGAGA GCCGCCTGGC TTTCCCTTCC AGTTCCGGGA GAGCGGCTGC CCGACTCAGG TCCGCCCGAC CAGGATCAGC CCCGCTCCTC CCCTCTTGAG GTGGTGCCTT CTCACATCTG TCCAGAGGCT GCAAGGATTC AGCATTATTC CTCCAGGAAG GAGCAAAACG CCTCTTTTCC CTCTCTAGGC CTGTTGCCTC GGGCCTGGGT CCGCCTTAAT CTGGAAGGCC CCTCCCAGCA GCGGTACCCC AGGGCCTACT GCCACCCGCT TCCTGTTTCT TAGTCCGAAT GTTAGATTCC TCTTGCCTCT CTCAGGAGTA TCTTACCTGT AAAGTCTAAT CTCTAAATCA AGTATTTATT ATTGAAGATT TACCATAAGG GACTGTGCCA GATGTTAGGA GAACTACTAA AGTGCCTACC CCAGCTC-3' (FRAG. NO:1897) (SEQ. ID NO: 1908)

5'-CATATGTATG GGAATACTGT ATTTCAGGCA TTATAAGGAA TGAAATTATA GGCCGGGCAT TGTGGCTAAC CCTTGTAATC CTAGCACTTT GAGAGGCTGA AGTGGGCAGA TCACTTGAGC TTCAGAGTTC GAGACCAGCA

TGGACAACAT GGTGAAACCC AGTCTCTACC AAAAACACAA AAATATTAGC TGGGTGTGGT GGTGCATGCC

TGTAGTCCCA GCTACTCAGG AGGCTGAGGT GGGAGGATCG CTTGAGCCTG GGAGGCAGAA GTTGCAATGA

GCAGAGATCG TGCCACTCCG CTCCAGTCTT GGTGACAGAA TGAGACTCCA TCTCAAAAAT AAATAAATAA

ATAAATAAAA TAAATGAAAT GAAATTATAA GAAATTACCA CTTTTTCATG TAAGAAGTGA TCATTTCCAT

TATAAGGGAA GGAATTTAAT CCTACCTGCC ATTCCACCAA AGCTTACCTA GTGCTAAAGG ATGAGGTGTT

AGTAAGACCA ACATCTCAGA GGCCTCTCTG TGCCAATAGC CTTCCTTCCT TTCCCTTCCA AAAACCTCAA

GTGACTAGTT CAGAGGCCTG TCTGGAATAA TGGCATCATC TAATATCACT GGCCTTCTGG AACCTGGGCA

TTTTCCAGTG TGTTCCATAC TGTCAATATT CCCCCAGCTT CCTGGACTCC TGTCACAAGC TGGAAAAGTG

AGAGGATGGA CAGGGATTAA CCAGAGAGCT CCCTGCTGAG GAAAAAATCT CCCAGATGCT GAAAGTGAGG

CCATGTGGCT TGGCCAAATA AAACCTGGCT CCGTGGTGCC TCTGTCTTAG CAGCCACCCT GCTGATGAAC

TGCCACCTTG GACTTGGGAC CAGAAAGAGG TGGGTTGGGT GAAGAGGCAC CACACAGAGT GATGTAACAG

CAAGATCAGG TCACCCACAG GCCCTGGCAG TCACAGTCAT AAATTAGCTA ACTGTACACA AGCTGGGGAC

ACTCCCTTTG GAAACCAAAA AAAAAAAAAA AAAAAAGAGA CCTTTATGCA AAAACAACTC TCTGGATGGC

ATGGGGTGAG TATAAATACT TCTTGGCTGC CAGTGTGTTC ATAACTTTGT AGCGAGTCGA AAACTGAGGC

TCCGGCCGCA GAGAACTCAG CCTCATTCCT GCTTTAAAAT CTCTCGGCCA CCTTTGATGA GGGGACTGGG

CAGTTCTAGA CAGTCCCGAA GTTCTCAAGG CACAGGTCTC TTCCTGGTTT GACTGTCCTT ACCCCGGGGA

GGCAGTGCAG CCAGCTGCAA GGTGAGTTGC C-3' (FRAG. NO: )(SEQ. ID NO: 2506) 5'-CTGCTTTAAA ATCTCTCGGC CACCTTTGAT GAGGGGACTG GGCAGTTCTA GACAGTCCCG AAGTTCTCAA GGCACAGGTC TCTTCCTGGT TTGACTGTCC TTACCCCGGG GAGGCAGTGC AGCCAGCTGC AAGCCCCACA GTGAAGAACA TCTGAGCTCA AATCCAGATA AGTGACATAA GTGACCTGCT TTGTAAAGCC ATAGAGATGG CCTGTCCTTG GAAATTTCTG TTCAAGACCA EPI-109 215

AATTCCACCA GTATGCAATG AATGGGGAAA AAGACATCAA CAACAATGTG GAGAAAGCCC CCTGTGCCAC CTCCAGTCCA GTGACACAGG ATGACCTTCA GTATCACAAC CTCAGCAAGC AGCAGAATGA GTCCCCGCAG CCCCTCGTGG AGACGGGAAA GAAGTCTCCA GAATCTCTGG TCAAGCTGGA TGCAACCCCA TTGTCCTCCC CACGGCATGT GAGGATCAAA AACTGGGGCA GCGGGATGAC TTTCCAAGAC ACACTTCACC ATAAGGCCAA AGGGATTTTA ACTTGCAGGT CCAAATCTTG CCTGGGGTCC ATTATGACTC CCAAAAGTTT GACCAGAGGA CCCAGGGACA AGCCTACCCC TCCAGATGAG CTTCTACCTC AAGCTATCGA ATTTGTCAAC CAATATTACG GCTCCTTCAA AGAGGCAAAA ATAGAGGAAC ATCTGGCCAG GGTGGAAGCG GTAACAAAGG AGATAGAAAC AACAGGAACC TACCAACTGA CGGGAGATGA GCTCATCTTC GCCACCAAGC AGGCCTGGCG CAATGCCCCA CGCTGCATTG GGAGGATCCA GTGGTCCAAC CTGCAGGTCT TCGATGCCCG CAGCTGTTCC ACTGCCCGGG AAATGTTTGA ACACATCTGC AGACACGTGC GTTACTCCAC CAACAATGGC AACATCAGGT CGGCCATCAC CGTGTTCCCC CAGCGGAGTG ATGGCAAGCA CGACTTCCGG GTGTGGAATG CTCAGCTCAT CCGCTATGCT GGCTACCAGA TGCCAGATGG CAGCATCAGA GGGGACCCTG CCAACGTGGA ATTCACTCAG CTGTGCATCG ACCTGGGCTG GAAGCCCAAG TACGGCCGCT TCGATGTGGT CCCCCTGGTC CTGCAGGCCA ATGGCCGTGA CCCTGAGCTC TTCGAAATCC CACCTGACCT TGTGCTTGAG GTGGCCATGG AACATCCCAA ATACGAGTGG TTTCGGGAAC TGGAGCTAAA GTGGTACGCC CTGCCTGCAG TGGCCAACAT GCTGCTTGAG GTGGGCGGCC TGGAGTTCCC AGGGTGCCCC TTCAATGGCT GGTACATGGG CACAGAGATC GGAGTCCGGG ACTTCTGTGA CGTCCAGCGC TACAACATCC TGGAGGAAGT GGGCAGGAGA ATGGGCCTGG AAACGCACAA GCTGGCCTCG CTCTGGAAAG ACCAGGCTGT CGTTGAGATC AACATTGCTG TGATCCATAG TTTTCAGAAG CAGAATGTGA CCATCATGGA CCACCACTCG GCTGCAGAAT CCTTCATGAA GTACATGCAG AATGAATACC GGTCCCGTGG GGGCTGCCCG GCAGACTGGA TTTGGCTGGT CCCTCCCATG TCTGGGAGCA TCACCCCCGT GTTTCACCAG GAGATGCTGA ACTACGTCCT GTCCCCTTTC TACTACTATC AGGTAGAGGC CTGGAAAACC CATGTCTGGC AGGACGAGAA GCGGAGACCC AAGAGAAGAG AGATTCCATT GAAAGTCTTG GTCAAAGCTG TGCTCTTTGC CTGTATGCTG ATGCGCAAGA CAATGGCGTC CCGAGTCAGA GTCACCATCC TCTTTGCGAC AGAGACAGGA AAATCAGAGG CGCTGGCCTG GGACCTGGGG GCCTTATTCA GCTGTGCCTT CAACCCCAAG GTTGTCTGCA TGGATAAGTA CAGGCTGAGC TGCCTGGAGG AGGAACGGCT GCTGTTGGTG GTGACCAGTA CGTTTGGCAA TGGAGACTGC CCTGGCAATG GAGAGAAACT GAAGAAATCG CTCTTCATGC TGAAAGAGCT CAACAACAAA TTCAGGTACG CTGTGTTTGG CCTCGGCTCC AGCATGTACC CTCGGTTCTG CGCCTTTGCT CATGACATTG ATCAGAAGCT GTCCCACCTG GGGGCCTCTC AGCTCACCCC GATGGGAGAA GGGGATGAGC TCAGTGGGCA GGAGGACGCC TTCCGCAGCT GGGCCGTGCA AACCTTCAAG GCAGCCTGTG AGACGTTTGA TGTCCGAGGC AAACAGCACA TTCAGATCCC CAAGCTCTAC ACCTCCAATG TGACCTGGGA CCCGCACCAC TACAGGCTCG TGCAGGACTC ACAGCCTTTG GACCTCAGCA AAGCCCTCAG CAGCATGCAT GCCAAGAACG TGTTCACCAT GAGGCTCAAA TCTCGGCAGA ATCTACAAAG TCCGACATCC AGCCGTGCCA CCATCCTGGT GGAACTCTCC TGTGAGGATG GCCAAGGCCT GAACTACCTG CCGGGGGAGC ACCTTGGGGT TTGCCCAGGC AACCAGCCGG CCCTGGTCCA AGGCATCCTG GAGCGAGTGG TGGATGGCCC CACACCCCAC CAGACAGTGC GCCTGGAGGA CCTGGATGAG AGTGGCAGCT ACTGGGTCAG TGACAAGAGG CTGCCCCCCT GCTCACTCAG CCAGGCCCTC ACCTACTCCC CGGACATCAC CACACCCCCA ACCCAGCTGC TGCTCCAAAA GCTGGCCCAG GTGGCCACAG AAGAGCCTGA GAGACAGAGG CTGGAGGCCC TGTGCCAGCC CTCAGAGTAC AGCAAGTGGA AGTTCACCAA CAGCCCCACA TTCCTGGAGG TGCTAGAGGA GTTCCCGTCC CTGCGGGTGT CTGCTGGCTT CCTGCTTTCC CAGCTCCCCA TTCTGAAGCC CAGGTTCTAC TCCATCAGCT CCTCCCGGGA TCACACGCCC ACGGAGATCC ACCTGACTGT GGCCGTGGTC ACCTACCACA CCGGAGATGG CCAGGGTCCC CTGCACCACG GTGTCTGCAG CACATGGCTC AACAGCCTGA AGCCCCAAGA CCCAGTGCCC TGCTTTGTGC GGAATGCCAG CGCCTTCCAC CTCCCCGAGG ATCCCTCCCA TCCTTGCATC CTCATCGGGC CTGGCACAGG CATCGTGCCC TTCCGCAGTT TCTGGCAGCA ACGGCTCCAT GACTCCCAGC ACAAGGGAGT GCGGGGAGGC CGCATGACCT TGGTGTTTGG GTGCCGCCGC CCAGATGAGG ACCACATCTA CCAGGAGGAG ATGCTGGAGA TGGCCCAGAA GGGGGTGCTG CATGCGGTGC ACACAGCCTA TTCCCGCCTG CCTGGCAAGC CCAAGGTCTA TGTTCAGGAC ATCCTGCGGC AGCAGCTGGC CAGCGAGGTG CTCCGTGTGC TCCACAAGGA GCCAGGCCAC CTCTATGTTT GCGGGGATGT GCGCATGGCC CGGGACGTGG CCCACACCCT GAAGCAGCTG GTGGCTGCCA AGCTGAAATT GAATGAGGAG CAGGTCGAGG ACTATTTCTT TCAGCTCAAG AGCCAGAAGC GCTATCACGA AGATATCTTC GGTGCTGTAT TTCCTTACGA GGCGAAGAAG GACAGGGTGG CGGTGCAGCC CAGCAGCCTG GAGATGTCAG CGCTCTGAGG GCCTACAGGA GGGGTTAAAG CTGCCGGCAC AGAACTTAAG GATGGAGCCA GCTCTGCATT ATCTGAGGTC ACAGGGCCTG GGGAGATGGA GGAAAGTGAT ATCCCCCAGC CTCAAGTCTT ATTTCCTCAA CGTTGCTCCC CATCAAGCCC TTTACTTGAC CTCCTAACAA GTAGCACCCT GGATTGATCG GAGCCTCCTC TCTCAAACTG GGGCCTCCCT GGTCCCTTGG AGACAAAATC TTAAATGCCA GGCCTGGCGA GTGGGTGAAA GATGGAACTT GCTGCTGAGT GCACCACTTC AAGTGACCAC CAGGAGGTGC TATCGCACCA CTGTGTATTT AACTGCCTTG TGTACAGTTA TTTATGCCTC TGTATTTAAA AAACTAACAC CCAGTCTGTT CCCCATGGCC ACTTGGGTCT TCCCTGTATG ATTCCTTGAT GGAGATATTT ACATGAATTG CATTTTACTT TAATC-3' (FRAG. NO:J(SEQ. ID NO:2507)

5'-GAATTCCCAC TCTGCTGCCT GCTCCAGCAG ACGGACGCAC AGTAACATGG GCAACTTGAA GAGCGTGGCC CAGGAGCCTG GGCCACCCTG CGGCCTGGGG CTGGGGCTGG GCCTTGGGCT GTGCGGCAAG CAGGGCCCAG CCACCCCGGC CCCTGAGCCC AGCCGGGCCC CAGCATCCCT ACTCCCACCA GCGCCAGAAC ACAGCCCCCC GAGCTCCCCG CTAACCCAGC CCCCAGAGGG GCCCAAGTTC CCTCGTGTGA AGAACTGGGA GGTGGGGAGC ATCACCTATG ACACCCTCAG CGCCCAGGCG CAGCAGGATG GGCCCTGCAC CCCAAGACGC TGCCTGGGCT CCCTGGTATT TCCACGGAAA CTACAGGGCC GGCCCTCCCC CGGCCCCCCG GCCCCTGAGC AGCTGCTGAG TCAGGCCCGG GACTTCATCA ACCAGTACTA CAGCTCCATT AAGAGGAGCG GCTCCCAGGC CCACGAACAG CGGCTTCAAG AGGTGGAAGC CGAGGTGGCA GCCACAGGCA CCTACCAGCT TAGGGAGAGC GAGCTGGTGT TCGGGGCTAA GCAGGCCTGG CGCAACGCTC CCCGCTGCGT GGGCCGGATC CAGTGGGGGA AGCTGCAGGT GTTCGATGCC CGGGACTGCA GGTCTGCACA GGAAATGTTC ACCTACATCT GCAACCACAT CAAGTATGCC ACCAACCGGG GCAACCTTCG CTCGGCCATC ACAGTGTTCC CGCAGCGCTG CCCTGGCCGA GGAGACTTCC GAATCTGGAA CAGCCAGCTG GTGCGCTACG CGGGCTACCG GCAGCAGGAC GGCTCTGTGC GGGGGGACCC AGCCAACGTG GAGATCACCG AGCTCTGCAT TCAGCACGGC TGGACCCCAG GAAACGGTCG CTTCGACGTG CTGCCCCTGC TGCTGCAGGC CCCAGATGAG CCCCCAGAAC TCTTCCTTCT GCCCCCCGAG CTGGTCCTTG AGGTGCCCCT GGAGCACCCC ACGCTGGAGT GGTTTGCAGC CCTGGGCCTG CGCTGGTACG CCCTCCCGGC AGTGTCCAAC ATGCTGCTGG AAATTGGGGG CCTGGAGTTC CCCGCAGCCC CCTTCAGTGG CTGGTACATG AGCACTGAGA TCGGCACGAG GAACCTGTGT GACCCTCACC GCTACAACAT CCTGGAGGAT GTGGCTGTCT GCATGGACCT GGATACCCGG ACCACCTCGT CCCTGTGGAA AGACAAGGCA GCAGTGGAAA TCAACGTGGC CGTGCTGCAC AGTTACCAGC TAGCCAAAGT CACCATCGTG GACCACCACG CCGCCACGGC CTCTTTCATG AAGCACCTGG AGAATGAGCA GAAGGCCAGG GGGGGCTGCC CTGCAGACTG GGCCTGGATC GTGCCCCCCA TCTCGGGCAG CCTCACTCCT GTTTTCCATC AGGAGATGGT CAACTATTTC CTGTCCCCGG CCTTCCGCTA CCAGCCAGAC CCCTGGAAGG GGAGTGCCGC CAAGGGCACC EPI-109 216

GGCATCACCA GGAAGAAGAC CTTTAAAGAA GTGGCCAACG CCGTGAAGAT CTCCGCCTCG CTCATGGGCA CGGTGATGGC

GAAGCGAGTG AAGGCGACAA TCCTGTATGG CTCCGAGACC GGCCGGGCCC AGAGCTACGC ACAGCAGCTG GGGAGACTCT

TCCGGAAGGC TTTTGATCCC CGGGTCCTGT GTATGGATGA GTATGACGTG GTGTCCCTCG AACACGAGAC GCTGGTGCTG

GTGGTAACCA GCACATTTGG GAATGGGGAT CCCCCGGAGA ATGGAGAGAG CTTTGCAGCT GCCCTGATGG AGATGTCCGG

CCCCTACAAC AGCTCCCCTC GGCCGGAACA GCACAAGAGT TATAAGATCC GCTTCAACAG CATCTCCTGC TCAGACCCAC

TGGTGTCCTC TTGGCGGCGG AAGAGGAAGG AGTCCAGTAA CACAGACAGT GCAGGGGCCC TGGGCACCCT CAGGTTCTGT

GTGTTCGGGC TCGGCTCCCG GGCATACCCC CACTTCTGCG CCTTTGCTCG TGCCGTGGAC ACACGGCTGG AGGAACTGGG

CGGGGAGCGG CTGCTGCAGC TGGGCCAGGG CGACGAGCTG TGCGGCCAGG AGGAGGCCTT CCGAGGCTGG GCCCAGGCTG

CCTTCCAGGC CGCCTGTGAG ACCTTCTGTG TGGGAGAGGA TGCCAAGGCC GCCGCCCGAG ACATCTTCAG CCCCAAACGG

AGCTGGAAGC GCCAGAGGTA CCGGCTGAGC GCCCAGGCCG AGGGCCTGCA GTTGCTGCCA GGTCTGATCC ACGTGCACAG

GCGGAAGATG TTCCAGGCTA CAATCCGCTC AGTGGAAAAC CTGCAAAGCA GCAAGTCCAC GAGGGCCACC ATCCTGGTGC

GCCTGGACAC CGGAGGCCAG GAGGGGCTGC AGTACCAGCC GGGGGACCAC ATAGGTGTCT GCCCGCCCAA CCGGCCCGGC

CTTGTGGAGG CGCTGCTGAG CCGCGTGGAG GACCCGCCGG CGCCCACTGA GCCCGTGGCA GTAGAGCAGC TGGAGAAGGG

CAGCCCTGGT GGCCCTCCCC CCGGCTGGGT GCGGGACCCC CGGCTGCCCC CGTGCACGCT GCGCCAGGCT CTCACCTTCT

TCCTGGACAT CACCTCCCCA CCCAGCCCTC AGCTCTTGCG GCTGCTCAGC ACCTTGGCAG AAGAGCCCAG GGAACAGCAG

GAGCTGGAGG CCCTCAGCCA GGATCCCCGA CGCTACGAGG AGTGGAAGTG GTTCCGCTGC CCCACGCTGC TGGAGGTGCT

GGAGCAGTTC CCGTCGGTGG CGCTGCCTGC CCCACTGCTC CTCACCCAGC TGCCTCTGCT CCAGCCCCGG TACTACTCAG

TCAGCTCGGC ACCCAGCACC CACCCAGGAG AGATCCACCT CACTGTAGCT GTGCTGGCAT ACAGGACTCA GGATGGGCTG

GGCCCCCTGC ACTATGGAGT CTGCTCCACG TGGCTAAGCC AGCTCAAGCC CGGAGACCCT GTGCCCTGCT TCATCCGGGG

GGCTCCCTCC TTCCGGCTGC CACCCGATCC CAGCTTGCCC TGCATCCTGG TGGGTCCAGG CACTGGCATT GCCCCCTTCC

GGGGATTCTG GCAGGAGCGG CTGCATGACA TTGAGAGCAA AGGGCTGCAG CCCACTCCCA TGACTTTGGT GTTCGGCTGC

CGATGCTCCC AACTTGACCA TCTCTACCGC GACGAGGTGC AGAACGCCCA GCAGCGCGGG GTGTTTGGCC GAGTCCTCAC

CGCCTTCTCC CGGGAACCTG ACAACCCCAA GACCTACGTG CAGGACATCC TGAGGACGGA GCTGGCTGCG GAGGTGCACC

GCGTGCTGTG CCTCGAGCGG GGCCACATGT TTGTCTGCGG CGATGTTACC ATGGCAACCA ACGTCCTGCA GACCGTGCAG

CGCATCCTGG CGACGGAGGG CGACATGGAG CTGGACGAGG CCGGCGACGT CATCGGCGTG CTGCGGGATC AGCAACGCTA

CCACGAAGAC ATTTTCGGGC TCACGCTGCG CACCCAGGAG GTGACAAGCC GCATACGCAC CCAGAGCTTT TCCTTGCAGG

AGCGTCAGTT GCGGGGCGCA GTGCCCTGGG CGTTCGACCC TCCCGGCTCA GACACCAACA GCCCCTGAGA GCCGCCTGGC

TTTCCCTTCC AGTTCCGGGA GAGCGGCTGC CCGACTCAGG TCCGCCCGAC CAGGATCAGC CCCGCTCCTC CCCTCTTGAG

GTGGTGCCTT CTCACATCTG TCCAGAGGCT GCAAGGATTC AGCATTATTC CTCCAGGAAG GAGCAAAACG CCTCTTTTCC

CTCTCTAGGC CTGTTGCCTC GGGCCTGGGT CCGCCTTAAT CTGGAAGGCC CCTCCCAGCA GCGGTACCCC AGGGCCTACT

GCCACCCGCT TCCTGTTTCT TAGTCCGAAT GTTAGATTCC TCTTGCCTCT CTCAGGAGTA TCTTACCTGT AAAGTCTAAT

CTCTAAATCA AGTATTTATT ATTGAAGATT TACCATAAGG GACTGTGCCA GATGTTAGGA GAACTACTAA AGTGCCTACC

CCAGCTC-3 ' ( FRAG . NO : _) ( SEQ . ID NO : 2508 )

5 -CCCCGGGG-3' (FRAG. NO:1898) (SEQ. ID NO: 1909)

5 -GGGGCCGCTGGG-3' (FRAG. NO:1899) (SEQ. ID NO:1910)

5 -GGGGGTGTGG-3' (FRAG. NO:1900) (SEQ. ID NO: 1911)

₅'-CTGCCTCCCCGGGGT-3' (FRAG. NO:1442)(SEQ. ED NO:1452)

5'-TTCTGCTGCTTGCTG-3' (FRAG. NO:1443)(SEQ. ID NO:1453)

5 ' -CT1 CTTTCCCGTCTCC-3 ' (FRAG. NO:1444)(SEQ. ID NO:1454)

5'-CTTCTTTCCCGTCTCC-3' (FRAG. NO:1445)(SEQ. ID NO:1455)

5'-TTTTTGCCTCTTTG-3' (FRAG. NO:1446)(SEQ. ID NO:1456)

5'-GGTTCCTGTTGTTTCT-3' (FRAG. NO:1447)(SEQ. ID NO:1457)

5'-GGCCTGCTTGGTGGCG-3' (FRAG. NO:1448)(SEQ. ID NO:1458)

5'-GCTTGTGCGTTTCC-3' (FRAG. NO:1449)(SEQ. ID NO:1459)

5' TCTCTCTTCTCTTGGGTCTCCGCπCTCGTCCTGCC-3' (FRAG. NO:1450)(SEQ. ID NO:1460)

5'-TTTTCCTGTCTCTGTCGC-3' (FRAG. NO:1451)(SEQ. ED NO:1461)

5'-GCCGTTCCTCCTCC-3' (FRAG. NO:1452)(SEQ. ID NO:1462)

S'-GGCGTCCTCCTGCCC-S' (FRAG. NO:1453)(SEQ. ID NO:1463)

S'-TGTGCTGTTTGCCTCGG-S' (FRAG NO 1454)(SEQ ID NO- 1464)

5'-GTGGTGCGGGTCCC-3' (FRAG NO 1455)(SEQ ID NO 1465)

5'-GGTGCTCCCCCGGC-3' (FRAG NO 1456)(SEQ ID NO 1466)

5'-GGGCCGGCTGGTTGCCTGGGC-3' (FRAG NO 1₄57)(SEQ ID NO 1467)

5'-CTGTCTGGTGGGGTGTGGGGCC-3' (FRAG NO 1458)(SEQ ID NO 1468)

5'-GCTGGGTTGGGGGTGTGGTG-3' (FRAG NO 1459)(SEQ ID NO 1469)

5'-GGCTCTTCTGTGGCC-3' (FRAG NO 1460)(SEQ ID NO 1470)

5'-TGTGGGGCTGTTGGTG-3' (FRAG NO 1461)(SEQ ID NO 1471)

5'-TCTCTGTGGGCGTGTG-3' (FRAG NO 1462)(SEQ ID NO 1472)

S'-CTGGGTCTTGGGGCTTC-S' (FRAG NO 1463)(SEQ ID NO 1473)

5'-CTCCCTTGTGCTGGG-3' (FRAG NO 1464)(SEQ ID NO 1474)

5'-TGCGGCCTCCCCGC-3' (FRAG NO 1465)(SEQ ID NO 1475)

5^•-CCCCCTTCTGGGCC-3^, (FRAG NO 1466)(SEQ ID NO 1476)

5'-GGTGGCCTGGCTCCTTGTGG 3" (FRAG NO 1467)(SEQ ID NO 1477)

5'-GCGCTTCTGGCTCTTG-3' (FRAG NO 1468)(SEQ ID NO 1478)

5'-CCCTGTCCTTCTTCGCCTCGT-3' (FRAG NO 1469)(SEQ ID NO 1479)

S'-GGCTGCTGGGCTGC-S' (FRAG NO 1470XSEQ ID NO 1480)

5'-CTGCCCCBGTTTTTGBTCCTCBCBTGCCGTGGGGBGGBCBBTGG-3' (FRAG. NO:1901) (SEQ. ED NO: 1912)

NF-kB Nucleic Acids and Antisense Oligonucleotide Fragments

5 -CGGCCCTTCT CACTGGAGGC ACCGGGCAGT CCTCCATGGG AGGGTTGGGC TTGGCCGGGG CTGCCCGGTG CCTCCTCTTG

GCTGGTCCCT CGTTGTCCTT GGGCCCCGC TCCCGCTGCT CGGCCTCCGT GTTCTTTGGC CTCTTGCTCC GCCTGCTGTC EPI-109 217

TTGTCCCGTC CCCTCCTCGC TTGCGTTTCC CTCTTCCTTG TCTTCCAGGC CTTCCTCCGC TTCCGCTGCT GGGGCCCGCG

CCGGGGGGGC GCTCGGCTCC GCGGCTTCCT CCCCGGCTGG GGGGTCCTGG TCTCCGGGGC CTGCGGCTCG CGGGCTCGGG

GCTGCGTGCG CCGCGCGCGG CGTCCGCGGT GGGTGGCGCT GTCCCGCCGT GGTGTGTCTC CGTTCTCGTC CTGCGCCGTC

CTGGTCTGCC CGTGGGGTCC TGGGCGTGGT GGGGGGCGTC TGGTGCCTCG TCTGCCCCGT GGGGCTTCGG GCTCGGGGCT

GTTCGTCCCC CCTGCCGCTC TGTGGCCTCC GGGGCTCCTC GTTTTCGCTG CTTCGGGTGT CCTTCTCGGC GTGTGGCCCC

GGGTCCCGGC CCTGCTGGGC TGGGCGGGGT CGCTGCCCTG GGCTTCTGGC CCGTCTGGTT GTCTGTCGGT GCTTGTCTCG

GGTTTCTGGC CTCTGTGCTG GGCGCTTCTC TGCCTCCTGC TCCGCCCTCC TGGTGGCTCG GCTGGGGGTG CCCGTGCGGG

GGTGGGTGTG GGGTGTTTTC GGGGTCCTCC CCTTCCC-3' (FRAG. NO:1902) (SEQ. ED NO:1913)

5 -GGGCGGGGTCGC-3' (FRAG. NO:1903) (SEQ. ED NO:1914)

5 -GCGCCGTCC-3' (FRAG. NO:1904) (SEQ. ID NO:1915)

5 -GGGCGTGGTGG-3' (FRAG. NO:1905) (SEQ. ID NO:1916)

5' GTTGGGCTTGGCCGGGG-3 (FRAG NO 1471)(SEQ ID NO 1481)

S'-CTGCCCGGTGCCTCC ' (FRAG NO 1472XSEQ ID NO 1482)

5 -TCTTGGCTGGTCCCTCGT-3' (FRAG NO 1473)(SEQ ID NO 1483)

5 -TGTCCTTGGGCCCC-3' (FRAG NO 1474)(SEQ ID NO 1484)

₅'-GCTCCCGCTGCTCGGCCTCCGT-3' (FRAG NO 1475)(SEQ ID NO 1485)

5' GTTCTTTGGCCTCTTGCTCC 3' (FRAG NO 1476)(SEQ ID NO 1486)

5 -GCCTGCTGTCTTGTCC 3' (FRAG NO 1477)(SEQ ID NO 1487)

5 -CGTCCCCTCCTCGCTTGCGTTTC-3' (FRAG NO 1478)(SEQ ID NO 1488)

5' CCTCTTCCTTGTCTTCCA-3 (FRAG NO 1479)(SEQ ID NO 1489)

5 -GGCCTTCCTCCGCTTCCGCTGC-3' (FRAG NO 1480)(SEQ ID NO 1490)

5'-TGGGGCCCGCGCCGG-3' (FRAG NO 1481)(SEQ ID NO 1491)

5 -GGGGGCGCTCGGCTCCGCGGCTTCCTCCCCGG-3' (FRAG NO 1482)(SEQ ID NO 1492)

5 CTGGGGGGTCCTGG-3' (FRAG NO 1483)(SEQ ID NO 1493)

5' TCTCCGGGGCCTGCGGCTCGC-3' (FRAG NO 1484)(SEQ ID NO 1494)

5 -GGGCTCGGGGCTGCGTGCGCC 3' (FRAG NO 1485)(SEQ ID NO 1495)

5' GCGCGCGGCGTCCGCGGTG 3' (FRAG NO 1486)(SEQ ID NO 1496)

5'-GGTGGCGCTGTCCCGCC-3' (FRAG NO 1487)(SEQ ID NO 1497)

5'-GTGGTGTGTCTCCGTTCTCGTCCTGCGCCGTC-3^, (FRAG NO 1488)(SEQ ID NO 1498)

5'-CTGGTCTGCCCGTGG-3' (FRAG NO 1489)(SEQ ID NO 1499)

5 -GGTCCTGGGCGTGGTGG-3' (FRAG NO 1490)(SEQ ID NO 1500)

5'-GGGGCGTCTGGTGC-3' (FRAG NO 1491)(SEQ ID NO 1501)

5'-CTCGTCTGCCCCGTG-3' (FRAG NO 1492)(SEQ ID NO 1502)

5'-GGGCTTCGGGCTCGG-3' (FRAG NO 1493)(SEQ ID NO 1503)

5'-GGCTGTTCGTCCCCCCTGCCGCTCTGTGGCCTCC-3' (FRAG NO 1494)(SEQ ID NO 1504)

5 -GGGGCTCCTCGTTTTC 3' (FRAG NO 1495)(SEQ ID NO 1505)

5 -GCTGCTTCGGGTGTCCTTCTC-3' (FRAG NO 1496)(SEQ ID NO 1506)

5 -GGCGTGTGGCCCCGG-3' (FRAG NO 1497)(SEQ ID NO 1507)

5'-GTCCCGGCCCTGCTGGGCTGGGCGGGGTC-3' (FRAG NO 1498)(SEQ ID NO 1508)

5 GCTGCCCTGGGCTTCTGGCCCGTCT-3' (FRAG NO 1499)(SEQ ID NO 1509)

5 -GGTTGTCTGTCGGT-3' (FRAG NO 1500)(SEQ ID NO 1510)

5'-GCTTGTCTCGGGTTTCTGG-3 (FRAG NO 1501)(SEQ ID NO 1511)

5 CCTCTGTGCTGGGC 3' (FRAG NO 1502)(SEQ ID NO 1512)

5 -GCTTCTCTGCCTCCTGCTCC 3 (FRAG NO 1503XSEQ ID NO 1513)

5 -GCCCTCCTGGTGGCTC 3' (FRAG NO 1504)(SEQ ID NO 1514)

5 -GGCTGGGGGTGCCCGTGCG 3 (FRAG NO 1505)(SEQ ID NO 1515)

5'-GGGGTGGGTGTGGGGTGTT-3 (FRAG NO 1506)(SEQ ID NO 1516)

5'-TTCGGGGTCCTCCCCTTCCC-3 (FRAG NO I507)(SEQ ID NO 1517)

5'-CGGCCCTTCTCACTGGAGGCACCGGGCAGTCCTCCATGGGAGG-3' (FRAG. NO:1906) (SEQ. ID NO:1917)

Human Major Basic Protein Nucleic Acids and Antisense Oligonucleotide Fragments

5'-GTT TCA TCT TGG CTT TAT CCTCT CCC CTT GTT CCT CCC CTCT CCT GCT CTG GRG TCT CCT C TTC CCT CCC TCC

CCT GCC GTG TTG TCT GTG GGT GTC GTT TCG CTC TTG TTG CCC TGG GCC CTT CCC TGC TGG GGG GGA GTT TCA TCT

TGG GTT TCB TCT TGG CTT TBT CCTCT CCC CTT GTT CCT CCC CTCT CCT GCT CTG GRG TCT CCT C TTC CCT CCC TCC

CCT GCC GTG TTG TCT GTG GGT GTC GTT TCG CTC TTG TTG CCC TGG GCC CTT CCC TGC TGG GGG GGB GTT TCB TCT

TGG-3' (FRAG. ED:1907) (SEQ. ED NO:1918)

5 -GGG GGA GTT-3' (FRAG. ED:1908) (SEQ. ED NO:1919)

5 -G CCC TGG GCC C-3' (FRAG. ED:1909) (SEQ. ID NO:1920)

5 -GTT TCA TCT TGG CTT TAT CC-3' (FRAG. NO:1508) (SEQ. ED NO:1518)

5 -TCT CCC CTT GTT CCT CCC C 3' (FRAG. NO:1509)(SEQ. ID NO:1519)

5'-TCT CCT GCT CTG GRG TCT CCT C-3' (FRAG. NO:1510)(SEQ. ED NO:1520)

5'-TTC CCT CCC TCC CCT GCC-3' (FRAG NO 1511)(SEQ ID NO 1521)

5' -GTG TTG TCT GTG GGT GTC C-3' (FRAG NO 1512XSEQ ID NO 1522)

5 -GTT TCG CTC TTG TTG CCC-3 (FRAG NO 1513)(SEQ ID NO 1523)

5 -TGG GCC CTT CCC TGC TGG-3' (FRAG NO 1514)(SEQ ID NO 1524)

5'-GGG GGA GTT TCA TCT TGG-3' (FRAG NO 1515)(SEQ ID NO 1525)

5 -GTT TCA TCT TGG CTT TAT CCTCT CCC CTT GTT CCT CCC CTCT CCT GCT CTG GRG TCT CCT C TTC CCT CCC TCC

CCT GCC GTG TTG TCT GTG GGT GTC GTT TCG CTC TTG TTG CCC TGG GCC CTT CCC TGC TGG GGG GGA GTT TCA TCT

TGG 3' (FRAG. ID:1910) (SEQ. ED NO:1921)

5 GTT TCB TCT TGG CTT TBT CCTCT CCC CTT GTT CCT CCC CTCT CCT GCT CTG GRG TCT CCT C TTC CCT CCC TCC EPI-109 218

CCT GCC GTG TTG TCT GTG GGT GTC GTT TCG CTC TTG TTG CCC TGG GCC CTT CCC TGC TGG GGG GGB GTT TCB TCT

TGG-3' (FRAG. ED:1911) (SEQ. ID NO:1922)

Human Eosinophil Major Basic Protein Nucleic Acids and Antisense Oligonucleotide Fragments

5'-GGG GGB GTT TCB TCT TGG CTT T-3' (FRAG NO 1516)(SEQ ID NO 1526)

5'-GGG GGB GTT TCB TCT TGG CTT-3' (FRAG NO 1517)(SEQ ID NO 1527)

5'-GGG GGB GTT TCB TCT TGG CT-3' (FRAG NO 1518)(SEQ ID NO 1528)

5'-GGG GGB GTT TCB TCT TGG C 3' (FRAG NO 1519)(SEQ ID NO 1529)

5'-GGG GGB GTT TCB TCT TGG-3' (FRAG NO 1520)(SEQ ID NO 1530)

5'-GGG GGB GTT TCB TCT TG 3' (FRAG NO 1521)(SEQ ID NO 1531)

5'-GGG GGB GTT TCB TCT T-3' (FRAG NO 1522)(SEQ ID NO 1532)

5'-GGG GGB GTT TCB TCT-3' (FRAG NO 1523)(SEQ ID NO 1533)

5 -GGG GGB GTT TCB TC-3' (FRAG NO 1524)(SEQ ID NO 1534)

5'-GGG GGB GTT TCB T-3' (FRAG NO 1525)(SEQ ID NO 1535)

5'-GGG GGB GTT TCB-3' (FRAG NO 1526)(SEQ ID NO.1536)

5'-GG GGB GTT TCB TCT TGG CTT T-3' (FRAG NO 1527)(SEQ ID NO 1537)

5'-GG GGB GTT TCB TCT TGG CTT-3' (FRAG NO 1528)(SEQ ID NO 1538)

5'-GG GGB GTT TCB TCT TGG CT-3' (FRAG NO 1529XSEQ ID NO 1539)

5'-GG GGB GTT TCB TCT TGG C-3' (FRAG NO 1530)(SEQ ID NO 1540)

5 GG GGB GTT TCB TCT TGG-3' (FRAG NO 1531)(SEQ ID NO 1541)

5 -GG GGB GTT TCB TCT TG-3' (FRAG NO 1532)(SEQ ID NO 1542)

5 -GG GGB GTT TCB TCT T-3' (FRAG NO 1533)(SEQ ID NO 1543)

5'-GG GGB GTT TCB TCT 3' (FRAG NO 1534)(SEQ ID NO 1544)

5 -GG GGB GTT TCB TC 3 (FRAG NO 1535)(SEQ ID NO 1545)

5 GG GGB GTT TCB T 3 (FRAG NO 1536)(SEQ ID NO 1546)

5 G GGB GTT TCB TCT TGG CTT T-3' (FRAG NO 1537)(SEQ ID NO 1547)

5 G GGB GTT TCB TCT TGG CTT-3' (FRAG NO 1538)(SEQ ID NO 1548)

5 -G GGB GTT TCB TCT TGG CT-3 (FRAG NO 1539)(SEQ ID NO 1549)

5 -G GGB GTT TCB TCT TGG C 3' (FRAG NO 1540)(SEQ ID NO 1550)

5 -G GGB GTT TCB TCT TGG 3' (FRAG NO 1541)(SEQ ID N0.1551)

5'-G GGB GTT TCB TCT TG 3' (FRAG NO 1542)(SEQ ID NO 1552)

5 G GGB GTT TCB TCT T-3' (FRAG NO 1543)(SEQ ID NO.1553)

5'-G GGB GTT TCB TCT-3' (FRAG NO 1544)(SEQ ID NO 1554)

5'-G GGB GTT TCB TC-3' (FRAG NO 1545XSEQ ID NO 1555)

5' -GGB GTT TCB TCT TGG CTT T-3' (FRAG NO 1546)(SEQ ID NO 1556)

5'-GGB GTT TCB TCT TGG CTT-3' (FRAG NO 1547)(SEQ ID NO 1557)

5'-GGB GTT TCB TCT TGG CT-3' (FRAG NO 1548)(SEQ ID NO 1558)

5' GGB GTT TCB TCT TGG C-3' (FRAG NO 1549)(SEQ ID NO 1559)

5'-GGB GTT TCB TCT TGG-3' (FRAG NO 1550)(SEQ ID NO 1560)

5'-GGB GTT TCB TCT TG-3' (FRAG NO 1551)(SEQ ID NO 1561)

5 -GGB GTT TCB TCT T-3' (FRAG NO 1552)(SEQ ID NO 1562)

5 -GGB GTT TCB TCT-3' (FRAG NO 1553)(SEQ ID NO 1563)

5 -GB GTT TCB TCT TGG CTT T-3' (FRAG NO 1554)(SEQ ID NO 1564)

5 GB GTT TCB TCT TGG CTT 3' (FRAG NO 1555XSEQ ID NO 1565)

5 GB GTT TCB TCT TGG CT 3' (FRAG NO 1556XSEQ ID NO 1566)

5 GB GTT TCB TCT TGG C-3 (FRAG NO 1557)(SEQ ID NO 1567)

5 -GB GTT TCB TCT TGG 3' (FRAG NO 1558)(SEQ ID NO 1568)

5 -GB GTT TCB TCT TG-3 (FRAG NO 1559)(SEQ ID NO 1569)

5 -GB GTT TCB TCT T 3 (FRAG NO 1560XSEQ ID NO 1570)

5'-B GTT TCB TCT TGG CTT T-3' (FRAG NO 1561)(SEQ ID NO 1571)

5 -B GTT TCB TCT TGG CTT 3' (FRAG NO 1562)(SEQ ID NO 1572)

5'-B GTT TCB TCT TGG CTT-3' (FRAG NO 1563)(SEQ ID NO 1573)

5'-B GTT TCB TCT TGG CT-3' (FRAG NO 1564)(SEQ ID NO 1574)

5'-B GTT TCB TCT TGG C-3' (FRAG NO 1565XSEQ ID NO 1575)

5 -B GTT TCB TCT TGG-3' (FRAG NO 1565)(SEQ ID NO 1576)

5'-B GTT TCB TCT TG-3' (FRAG NO 1567)(SEQ ID NO 1577)

5' GTT TCB TCT TGG CTT T-3 (FRAG NO 1568)(SEQ ID NO 1578)

5 -GTT TCB TCT TGG CTT 3 (FRAG NO 1569XSEQ ID NO 1579)

5 -GTT TCB TCT TGG CT-3 (FRAG NO 1570XSEQ ID NO 1580)

5'-GTT TCB TCT TGG C-3' (FRAG NO 1571)(SEQ ID NO 1581)

5'-GTT TCB TCT TGG-3' (FRAG NO 1572)(SEQ ID NO 1582)

5 -TT TCB TCT TGG CTT T-3' (FRAG NO 1573)(SEQ ID NO 1583)

5 -TT TCB TCT TGG CTT-3 (FRAG NO 1574)(SEQ ID NO 1584)

5'-TT TCB TCT TGG CT-3 (FRAG NO 1575)(SEQ ID NO 1585)

₅'-TT TCB TCT TGG C-3' (FRAG NO 1576)(SEQ ID NO 1586)

5'-T TCB TCT TGG CTT T-3' (FRAG NO 1577)(SEQ ID NO 1587)

5'-T TCB TCT TGG CTT-3' _(FRAG NO 1578)(SEQ ID NO 1588)

5' T TCB TCT TGG CT-3' (FRAG NO 1579XSEQ ID NO 1589) ₅'-TCB TCT TGG CTT T-3' (FRAG NO 1580)(SEQ ID NO 1590) 5' -TCB TCT TGG CTT-3' (FRAG NO 1581)(SEQ ID NO 1591) EPI-109 219

5 -GGG GGB GTT TCB TCT TGG CTT T 3' (FRAG NO 1582)(SEQ ID NO 1592)

5 -GG GGB GTT TCB TCT TGG CTT T 3 (FRAG NO 1583XSEQ ID NO 1593)

5'-G GGB GTT TCB TCT TGG CTT T-3' (FRAG NO 1584)(SEQ ID NO 1594)

5 -GGB GTT TCB TCT TGG CTT T-3' (FRAG NO 1585)(SEQ ID NO 1595)

5'-GB GTT TCB TCT TGG CTT T-3 (FRAG NO 1586)(SEQ ID NO 1596)

5 -B GTT TCB TCT TGG CTT T-3' (FRAG NO 1587)(SEQ ID NO 1597)

5' GTT TCB TCT TGG CTT T 3' (FRAG NO 1588)(SEQ ID NO 1598)

5 TT TCB TCT TGG CTT T 3' (FRAG NO 1589)(SEQ ID NO 1599)

5 T TCB TCT TGG CTT T 3' (FRAG NO 1590)(SEQ ID NO 1600)

5 -TCB TCT TGG CTT T 3' (FRAG NO 1591)(SEQ ID NO 1601)

5 -CB TCT TGG CTT T 3 (FRAG NO 1592)(SEQ ID NO 1602)

5 -GGG GGB GTT TCB TCT TGG CTT 3' (FRAG NO 1593XSEQ ID NO 1603)

5'-GG GGB GTT TCB TCT TGG CTT 3' (FRAG NO 1594)(SEQ ID NO 1604)

5 -G GGB GTT TCB TCT TGG CTT-3' (FRAG NO 1595)(SEQ ID NO 1605)

5 -GGB GTT TCB TCT TGG CTT-3' (FRAG NO 1596)(SEQ ID NO 1606)

5'-GB GTT TCB TCT TGG CTT 3' (FRAG. NO:1597)(SEQ. ID NO:1607)

5 -B GTT TCB TCT TGG CTT-3' (FRAG NO 1598)(SEQ ID NO 1608)

5' GTT TCB TCT TGG CTT-3 (FRAG. NO:1599)(SEQ. ID NO:1609)

5'-TT TCB TCT TGG CTT-3' (FRAG NO 1600)(SEQ ID NO 1610)

5' T TCB TCT TGG CTT 3' (FRAG NO 1601)(SEQ ID NO 1611)

5' TCB TCT TGG CTT 3' (FRAG NO 1602XSEQ ID NO 1612)

5'-GGG GGB GTT TCB TCT TGG CT 3' (FRAG NO 1603XSEQ ID NO 1613)

5' GG GGB GTT TCB TCT TGG CT-3' (FRAG NO 1604)(SEQ ID NO 1614)

5 G GGB GTT TCB TCT TGG CT-3' (FRAG NO I605)(SEQ ID NO 1615)

5 GGB GTT TCB TCT TGG CT 3' (FRAG NO 1606)(SEQ ID NO 1616)

5'-GB GTT TCB TCT TGG CT-3' (FRAG NO 1607)(SEQ ID NO 1617) '-B GTT TCB TCT TGG CT 3 (FRAG NO 1608XSEQ ID NO 1618)

5' GTT TCB TCT TGG CT 3 (FRAG NO 1609)(SEQ ID NO 1619)

5' TT TCB TCT TGG CT-3 (FRAG NO 1610)(SEQ ID NO 1620)

5'-T TCB TCT TGG CT-3' (FRAG NO 1611)(SEQ ID NO 1621) '-GGG GGB GTT TCB TCT TGG C-3' (FRAG NO 1612)(SEQ ID NO 1622) '-GG GGB GTT TCB TCT TGG C-3 (FRAG NO 1613)(SEQ ID NO 1623) -G GGB GTT TCB TCT TGG C 3' (FRAG NO 1614)(SEQ ID NO 1624)

5'-GGB GTT TCB TCT TGG C-3' (FRAG NO 1615)(SEQ ID NO 1625)

5'-GB GTT TCB TCT TGG C 3 (FRAG NO 1616)(SEQ ID NO 1626)

5'-B GTT TCB TCT TGG C-3' (FRAG NO 1617)(SEQ ID NO 1627) '-GTT TCB TCT TGG C-3' (FRAG NO 1618)(SEQ ID NO 1628) '-TT TCB TCT TGG C-3 (FRAG NO 1619XSEQ ID NO 1629)

5 -GGG GGB GTT TCB TCT TGG-3' (FRAG NO 1620)(SEQ ID NO 1630)

5' GG GGB GTT TCB TCT TGG 3' (FRAG NO 1621)(SEQ ID NO 1631)

5'-G GGB GTT TCB TCT TGG 3' (FRAG NO 1622)(SEQ ID NO 1632)

5'-GGB GTT TCB TCT TGG-3' (FRAG NO 1623)(SEQ ID NO 1633) -GB GTT TCB TCT TGG-3' (FRAG NO 1624)(SEQ ID NO 1634)

5 B GTT TCB TCT TGG-3 (FRAG. NO:1625)(SEQ. ID NO:1635)

5 GTT TCB TCT TGG-3' (FRAG. NO:1626)(SEQ. ID NO:1636)

5'-GGG GGB GTT TCB TCT TG-3' (FRAG. NO:1627)(SEQ. ID NO:1637) -GG GGB GTT TCB TCT TG-3' (FRAG. NO:1628)(SEQ. ID NO:1638) -G GGB GTT TCB TCT TG-3' (FRAG. NO:1629)(SEQ. ED NO:1639)

5 -GGB GTT TCB TCT TG-3' (FRAG. NO:1630)(SEQ. ID NO:1640)

5'-GB GTT TCB TCT TG-3' (FRAG NO 1631)(SEQ ID NO 1641) '-B GTT TCB TCT TG-3' (FRAG NO 1632)(SEQ ID NO 1642) '-GGG GGB GTT TCB TCT T-3 (FRAG NO 1633)(SEQ ID NO 1643) -GG GGB GTT TCB TCT T 3' (FRAG NO 1634)(SEQ ID NO 1644) -G GGB GTT TCB TCT T-3' (FRAG NO 1635)(SEQ ID NO 1645)

5 -G GGB GTT TCB TCT T 3' (FRAG NO 1636)(SEQ ID NO 1646)

5'-GGB GTT TCB TCT T 3' (FRAG NO 1637)(SEQ ID NO 1647)

5'-GB GTT TCB TCT T-3' (FRAG NO 1638)(SEQ ID NO 1648) '-GGG GGB GTT TCB TCT 3' (FRAG NO 1639)(SEQ ID NO 1649) -GG GGB GTT TCB TCT-3' (FRAG NO 1640)(SEQ ID NO 1650)

5 -G GGB GTT TCB TCT-3' (FRAG NO 1641)(SEQ ID NO 1651)

5 -GGB GTT TCB TCT 3' (FRAG NO 1642)(SEQ ID NO 1652)

5'-GGG GGB GTT TCB TC-3' (FRAG NO 1643)(SEQ ID NO 1653)

5'-GG GGB GTT TCB TC-3' (FRAG NO 1644)(SEQ ID NO 1654)

5'-G GGB GTT TCB TC-3' (FRAG NO 1645XSEQ ID NO 1655)

5'-GGG GGB GTT TCB T-3' (FRAG NO 1646XSEQ ID NO 1656)

5'-GG GGB GTT TCB T 3' (FRAG NO 1647)(SEQ ID NO 1657)

5 GGG GGB GTT TCB-3' (FRAG NO 1648XSEQ ID NO 1658)

5 -TCT CCC CTT GTT CCT CCC C 3 (FRAG NO 1649)(SEQ ID NO 1659)

5'-TCT CCT GCT CTG GTG TCT CCT C-3 (FRAG NO 1650)(SEQ ID NO 1660) EPI-109 220

5'-TTC CCT CCC TCC CCT GCC-3' (FRAG. NO:1651)(SEQ. ID NO:1661)

5'-GTG TTG TCT GTG GGT GTC C-3' (FRAG. NO:1652)(SEQ. ID NO:1662)

5'-GTT TCG CTC TTG TTG CCC-3' -3' (FRAG. NO:1653)(SEQ. ID NO:1663)

5 -TGG GCC CTT CCC TGC TGG-3' (FRAG. NO:1654)(SEQ. ID NO:1664)

5 -GGG GGB G-3' (FRAG. NO:1912)(SEQ. ID NO:1923)

5 -GTG GGT GTC C-3' (FRAG. NO:1913) (SEQ. ED NO:1924)

BP-1 Nucleic Acids and Antisense Oligonucleotide Fragments

5'-CCGTGTTGTC BGTGGTGCTG CCCGTTTCBG GTBTGGCGCT CCBCCBBTTC CCTTTTCTCC TTGTTTTCCG TTTCTCTTGC

CGTCTGTGGT T-3' (FRAG. NO:1914) (SEQ. ID NO:1925)

5'-CCCGTTTGBGGTBTGGC-3^,(FRAG. NO:1915) (SEQ. ID NO:1926)

5'-GCTCCBCCBBTTCCCTTTTCTCC-3'(FRAG. NO:1916) (SEQ. ID NO:1927)

S'-TTGTTTTCCGTTTCTCTTG^^FRAG. NO:1917) (SEQ. ID NO:1928)

5'-CCGTCTGTGGTT-3'(FRAG. NO:19I8) (SEQ. ID NO:1929)

5'-CCCGTTTGAGGTATGGC-3'(FRAG. NO:1919) (SEQ. ID NO:1930)

5'-GCTCCBCCAATTCCCTTTTCTCC-3'(FRAG. NO:1920) (SEQ. ID NO:1931)

C/EBPNucleic Acids and Antisense Oligonucleotide Antisense Oligonucleotide Fragments 5'-GGGCCCBGCCCCGCCGCCTTTTCTBGCCCC GGCC-3' (FRAG. NO:1921) (SEQ. ID NO:1932) 5'-GGGCCCBGCCCCGCCGCCTrπ'CTBGCCCC GGC-3' (FRAG. NO:1922) (SEQ. ID NO:1933) 5 -GGGCCCB GCCCCGCCGCCTTTTCTBGCCCCGG-3' (FRAG. NO: 1923) (SEQ. ID NO: 1934) 5 -GGGCCCBGCCCCGCCGCCTTTTCTBGCCCCG-3' (FRAG. NO:1924) (SEQ. ID NO:1935) 5'-GGGCCCBGCCCCGCCGCCTTTTCTBGCCCC-3' (FRAG. NO:1925) (SEQ. ID NO:1936) ₅'-GGGCCCBGCCCCGCCGCCTTTTCTBGCCC-3' (FRAG. NO:1926) (SEQ. ID NO:1937) 5'-GGGCCCBGCCCCGCCGCCTTTTCTBGCC-3' (FRAG. NO:1927) (SEQ. ID NO:1938) 5'-GGGCCCBGCCCCGCCGCCTTTTCTBGC-3' (FRAG. NO:1928) (SEQ. ID NO:1939) 5'-GGGCCCBGCCCCGCCGCCTTTTCTBG-3' (FRAG. NO:1929) (SEQ. ID NO:1940) 5'-GGGCCCBGCCCCGCCGCCTTTTCTB-3' (FRAG. NO:1930) (SEQ. ID NO:1941) 5'-GGGCCCBGCCCCGCCGCCTTTTCT-3' (FRAG. NO:1931) (SEQ. ID NO:1942) 5'-GGGCCCBGCCCCGCCGCCTTTTC-3' (FRAG. NO:I932) (SEQ. ID NO:I943) 5'-GGGCCCBGCCCCGCCGCCTTTT-3' (FRAG. NO:1933) (SEQ. ID NO:1944) 5'-GGGCCCBGCCCCGCCGCCTTT-3' (FRAG. NO:1934) (SEQ. ID NO:1945) 5 -GGGCCCBGCCCCGCCGCCTT-3' (FRAG. NO:1935) (SEQ. ID NO:1946) 5'-GGGCCCBGCCCCGCCGCCT-3' (FRAG. NO:1936) (SEQ. ID NO:I947) 5'-GGGCCCBGCCCCGCCGCC-3' (FRAG. NO:1937) (SEQ. ID NO:1948) 5'-GGGCCCBGCCCCGCCGC-3' (FRAG. NO:1938) (SEQ. ID NO:1949) 5'-GGGCCCBGCCCCGCCG-3' (FRAG. NO:1939) (SEQ. ID NO:1950) 5'-GGGCCCBGCCCCGCC-3' (FRAG. NO:1940) (SEQ. ID NO:1951) 5'-GGGCCCBGCCCCGC-3' (FRAG. NO:1941) (SEQ. ID NO:1952) 5'-GGGCCCBGCCCCG-3' (FRAG. NO:1942) (SEQ. ID NO:1953) 5'-GGGCCCBGCCCC-3' (FRAG. NO:1943) (SEQ. ID NO:1954) 5'-GGGCCCBGCCC-3' (FRAG. NO:1944) (SEQ. ID NO:1955)

5 -GGCCCBGCCCCGCCGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1945) (SEQ. ID NO:1956) 5 -GCCCBGCCCCGCCGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1946) (SEQ. ID NO:I957) 5'-CCCBGCCCCGCCGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1947) (SEQ. ID NO:1958) 5'-CCBGCCCCGCCGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1948) (SEQ. ID NO:1959) 5'-CBGCCCCGCCGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1948) (SEQ. ID NO:1960) 5'-BGCCCCGCCGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1950) (SEQ. ID NO:1961) 5'-GCCCCGCCGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1951) (SEQ. ID NO:1962) 5'-CCCCGCCGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1952) (SEQ. ID NO:1963) 5'-CCCGCCGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1953) (SEQ. ID NO:1964) 5'-CCGCCGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1954) (SEQ. ID NO:1965) 5'-CGCCGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1955) (SEQ. ID NO:1966) 5'-GCCGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1956) (SEQ. ID NO:1967) 5'-CCGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1957) (SEQ. ID NO:1968) S'-CGCCTTTTCTBGCCCCGGC-S' (FRAG. NO:1958) (SEQ. ID NO:1969) 5'-GCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1959) (SEQ. ID NO:1970) ^,, _{CCTTTTCTBGCCCCGGC 3}, _{(FRAG NO:},9₆₀) SEQ. ID NO:1971)

5'-CTTTTCTBGCCCCGGC-3' (FRAG. NO:1961) (SEQ. ID NO:1972) 5'-TTTTCTBGCCCCGGC-3' (FRAG. NO:1962) (SEQ. ID NO:1973) 5'-TTTCTBGCCCCGGC-3' (FRAG. NO:1963) (SEQ. ID NO:1974) 5'-TTCTBGCCCCGGC-3' (FRAG. NO:1964) (SEQ. ID NO:1975) 5'-TCTBGCCCCGGC-3' (FRAG. NO:1965) (SEQ. ID NO:1976) 5'-CTBGCCCCGGC-3' (FRAG. NO:I966) (SEQ. ID NO:1977) 5'-GCGBGGCTGTCBCCTCGCTGGGCCC-3' (FRAG. NO:1967) (SEQ. ID NO:1978) 5'-GCGBGGCTGTCBCCTCGCTGGGCC-3' (FRAG. NO:1968) (SEQ. ID NO:1979) 5'-GCGBGGCTGTCBCCTCGCTGGGC-3' (FRAG. NO:1969) (SEQ. ID NO:1980) EPI-109 221

5'-GCGBGGCTGTCBCCTCGCTGGG-3' (FRAG. NO:1970) (SEQ. ID NO:1981) 5'-GCGBGGCTGTCBCCTCGCTGG-3' (FRAG. NO:1971) (SEQ. ID NO:1982) 5'-GCGBGGCTGTCBCCTCGCTG-3' (FRAG. NO:1972) (SEQ. ID NO:1983) 5'-GCGBGGCTGTCBCCTCGCT-3' (FRAG. NO:1973) (SEQ. ID NO:1984) 5'-GCGBGGCTGTCBCCTCGC-3' (FRAG. NO:1974) (SEQ. ID NO:1985) 5'-GCGBGGCTGTCBCCTCG-3' (FRAG. NO:1975) (SEQ. ID NO:1986) 5 -GCGBGGCTGTCBCCTC-3' (FRAG. NO:1976) (SEQ. ID NO:1987) 5 -GCGBGGCTGTCBCCT-3' (FRAG. NO:1977) (SEQ. ID NO:1988) 5 -GCGBGGCTGTCBCC-3' (FRAG. NO:1978) (SEQ. ID NO:1989) 5 -GCGBGGCTGTCBC-3' (FRAG. NO:1979) (SEQ. ID NO:1990) 5 -GCGBGGCTGTCB-3' (FRAG. NO:1980) (SEQ. ID NO:1991) 5 -GCGBGGCTGTC-3' (FRAG. NO:1981) (SEQ. ID NO:1992) 5'-GCGBGGCTGT-3' (FRAG. NO:1982) (SEQ. ID NO:1993) 5'-CGBGGCTGTCBCCTCGCTGGGCCC-3' (FRAG. NO:1983) (SEQ. ID NO:1994) 5'-GBGGCTGTCBCCTCGCTGGGCCC-3' (FRAG. NO:1984) (SEQ. ID NO:1995) 5'-BGGCTGTCBCCTCGCTGGGCCC-3' (FRAG. NO:1985) (SEQ. ID NO:1996) 5'-GGCTGTCBCCTCGCTGGGCCC-3' (FRAG. NO:1986) (SEQ. ID NO:1997) 5'-GCTGTCBCCTCGCTGGGCCC-3' (FRAG. NO:1987) (SEQ. ID NO:1998) 5'-CTGTCBCCTCGCTGGGCCC-3' (FRAG. NO:1988) (SEQ. ID NO:1999) 5'-TGTCBCCTCGCTGGGCCC-3' (FRAG. NO:1989) (SEQ. ID Nθ:2000) 5'-GTCBCCTCGCTGGGCCC-3' (FRAG. NO:1990) (SEQ. ID Nθ:2001) 5'-TCBCCTCGCTGGGCCC-3' (FRAG. NO:I991) (SEQ. ID NO:2002) 5 -CBCCTCGCTGGGCCC-3' (FRAG. NO:1992) (SEQ. ID NO:2003) 5 -BCCTCGCTGGGCCC-3' (FRAG. NO:1993) (SEQ. ID NO:2004) 5 -CCTCGCTGGGCCC-3' (FRAG. NO:1994) (SEQ. ID NO:2005) 5 -CTCGCTGGGCCC-3' (FRAG. NO:1995) (SEQ. ID NO:2006) 5 -TCGCTGGGCCC-3' (FRAG. NO:1996) (SEQ. ID NO:2007) 5'-CGCTGGGCCC-3' (FRAG. NO:1997) (SEQ. ID NO:2008)

5 -GCGCGGCCGTCBTGGCGGCGTCGGGCCGGGC-3' (FRAG. NO:1998) (SEQ. ID NO:2009) 5 -GCGCGGCCGTCBTGGCGGCGTCGGGCCGGG-3' (FRAG. NO:1999) (SEQ. ID Nθ:2010) 5'-GCGCGGCCGTCBTGGCGGCGTCGGGCCGG-3' (FRAG. Nθ:2000) (SEQ. ID Nθ:2011) 5'-GCGCGGCCGTCBTGGCGGCGTCGGGCCG-3' (FRAG. Nθ:2001) (SEQ. ID NO:20I2) 5'-GCGCGGCCGTCBTGGCGGCGTCGGGCC-3' (FRAG. NO:2002) (SEQ. ID NO:20I3) 5'-GCGCGGCCGTCBTGGCGGCGTCGGGC-3' (FRAG. NO:2003) (SEQ. ID NO:2014) 5'-GCGCGGCCGTCBTGGCGGCGTCGGG-3' (FRAG. NO:2004) (SEQ. ID NO:2015) 5'-GCGCGGCCGTCBTGGCGGCGTCGG-3' (FRAG. NO:2005) (SEQ. ID NO:2016) 5'-GCGCGGCCGTCBTGGCGGCGTCG-3' (FRAG. NO:2006) (SEQ. ID NO:20I7) 5'-GCGCGGCCGTCBTGGCGGCGTC-3' (FRAG. NO:2007) (SEQ. ID NO:2018) 5 -GCGCGGCCGTCBTGGCGGCGT-3' (FRAG. NO:2008) (SEQ. ID NO:2019) 5'-GCGCGGCCGTCBTGGCGGCG-3' (FRAG. NO:2009) (SEQ. ID NO:2020) 5'-GCGCGGCCGTCBTGGCGGC-3' (FRAG. NO:20I0) (SEQ. ID NO:2021) 5 -GCGCGGCCGTCBTGGCGG-3' (FRAG. NO:2011) (SEQ. ID NO:2022) 5 -GCGCGGCCGTCBTGGCG-3' (FRAG. NO:2012) (SEQ. ID NO:2023) 5'-GCGCGGCCGTCBTGGC-3' (FRAG. NO:2013) (SEQ. ID NO:2024) 5 -GCGCGGCCGTCBTGG-3' (FRAG. NO:2014) (SEQ. ID NO:2025) 5 -GCGCGGCCGTCBTG-3' (FRAG. NO:2015) (SEQ. ID NO:2026) 5 -GCGCGGCCGTCBT-3' (FRAG. NO:2016) (SEQ. ID NO:2027) 5'-GCGCGGCCGTCB-3' (FRAG. NO:2017) (SEQ. ID NO:2028) 5 -GCGCGGCCGTC-3' (FRAG. NO:2018) (SEQ. ID NO:2029) 5'-GCGCGGCCGT-3' (FRAG. NO:2019) (SEQ. ID NO:2030)

5 -CGCGGCCGTCBTGGCGGCGTCGGGCCGGGC-3' (FRAG. NO:2020) (SEQ. ID NO:2031) 5 -GCGGCCGTCBTGGCGGCGTCGGGCCGGGC-3' (FRAG. NO:2021) (SEQ. ID NO:2032) 5'-CGGCCGTCBTGGCGGCGTCGGGCCGGGC-3' (FRAG. NO:2022) (SEQ. ID NO:2033) 5'-GGCCGTCBTGGCGGCGTCGGGCCGGGC-3' (FRAG. NO:2023) (SEQ. ID NO:2034) 5 -GCCGTCBTGGCGGCGTCGGGCCGGGC-3' (FRAG. NO:2024) (SEQ. ID NO:2035) 5 -CCGTCBTGGCGGCGTCGGGCCGGGC-3' (FRAG. NO:2025) (SEQ. ID NO:2036) 5 -CGTCBTGGCGGCGTCGGGCCGGGC-3' (FRAG. NO:2026) (SEQ. ID NO:2037) 5 -GTCBTGGCGGCGTCGGGCCGGGC-3' (FRAG. NO:2027) (SEQ. ID NO:2038) 5'-TCBTGGCGGCGTCGGGCCGGGC-3' (FRAG. NO:2028) (SEQ. ID NO:2039) ₅'-CBTGGCGGCGTCGGGCCGGGC-3' (FRAG. NO:2029) (SEQ. ID NO:2040) ₅'-BTGGCGGCGTCGGGCCGGGC-3' (FRAG. NO:2030) (SEQ. ID NO:2041) 5'-TGGCGGCGTCGGGCCGGGC-3' (FRAG. NO:2031) (SEQ. ID NO:2042) 5'-GGCGGCGTCGGGCCGGGC-3' (FRAG. NO:2032) (SEQ. ID NO:2043) 5 -GCGGCGTCGGGCCGGGC-3' (FRAG. NO:2033) (SEQ. ID NO:2044) 5 -CGGCGTCGGGCCGGGC-3' (FRAG. NO:2034) (SEQ. ID NO:2045) EPI-109 222

5'-GGCGTCGGGCCGGGC-3' (FRAG. NO:2035) (SEQ. ID NO:2046) 5'-GCGTCGGGCCGGGC-3' (FRAG. NO:2036) (SEQ. ID NO:2047) 5'-CGTCGGGCCGGGC-3' (FRAG. NO:2037) (SEQ. ID NO:2048) 5'-GTCGGGCCGGGC-3' (FRAG. NO:2038) (SEQ. ID NO:2049) 5'-TCGGGCCGGGC-3' (FRAG. NO:2039) (SEQ. ID NO:2050) 5'-CGGGCCGGGC-3' (FRAG. NO:2040) (SEQ. ID NO:2051)

5'-CCGCBGGCCBGGGCGCGCCGCCGGCCGGGCCG-3' (FRAG. NO:2041) (SEQ. ID NO:2052) 5'-CCGCBGGCCBGGGCGCGCCGCCGGCCGGGCC-3' (FRAG. NO:2042) (SEQ. ID NO:2053) 5'-CCGCBGGCCBGGGCGCGCCGCCGGCCGGGC-3' (FRAG. NO:2043) (SEQ. ID NO:2054) 5'-CCGCBGGCCBGGGCGCGCCGCCGGCCGGG-3' (FRAG. NO:2044) (SEQ. ID NO:2055) 5'-CCGCBGGCCBGGGCGCGCCGCCGGCCGG-3' (FRAG. NO:2045) (SEQ. ID NO:2056) 5'-CCGCBGGCCBGGGCGCGCCGCCGGCCG-3' (FRAG. NO:2046) (SEQ. ID NO:2057) 5'-CCGCBGGCCBGGGCGCGCCGCCGGCC-3' (FRAG. NO:2047) (SEQ. ID NO:2058) 5'-CCGCBGGCCBGGGCGCGCCGCCGGC-3' (FRAG. NO:2048) (SEQ. ID NO:2059) 5'-CCGCBGGCCBGGGCGCGCCGCCGG-3' (FRAG. NO:2049) (SEQ. ID NO:2060) '-CCGCBGGCCBGGGCGCGCCGCCG-3' (FRAG. NO:2050) (SEQ. ID NO:2061) '-CCGCBGGCCBGGGCGCGCCGCC-3' (FRAG. NO:2051) (SEQ. ID NO:2062) '-CCGCBGGCCBGGGCGCGCCGC-3' (FRAG. NO:2052) (SEQ. ID NO:2063) '-CCGCBGGCCBGGGCGCGCCG-3' (FRAG. NO:2053) (SEQ. ID NO:2064) '-CCGCBGGCCBGGGCGCGCC-3' (FRAG. NO:2054) (SEQ. ID NO:2065) -CCGCBGGCCBGGGCGCGC-3' (FRAG. NO:2055) (SEQ. ID NO:2066) '-CCGCBGGCCBGGGCGCG-3' (FRAG. NO:2056) (SEQ. ID NO:2067) '-CCGCBGGCCBGGGCGC-3' (FRAG. NO:2057) (SEQ. ID NO:2068) -CCGCBGGCCBGGGCG-3' (FRAG. NO:2058) (SEQ. ID NO:2069) -CCGCBGGCCBGGGC-3' (FRAG. NO:2059) (SEQ. ID NO:2070) '-CCGCBGGCCBGGG-3' (FRAG. NO:2060) (SEQ. ID NO:2071) -CCGCBGGCCBGG-3' (FRAG. NO:2061) (SEQ. ID NO:2072) '-CCGCBGGCCBG-3" (FRAG. NO:2062) (SEQ. ID NO:2073) '-CCGCBGGCCB-3' (FRAG. NO:2063) (SEQ. ID NO:2074) -CCGCBGGCC-3' (FRAG. NO:2064) (SEQ. ID NO:2075) '-CGCBGGCCBGGGCGCGCCGCCGGCCGGGCCG-3' (FRAG. NO:2065) (SEQ. ID NO:2076) -GCBGGCCBGGGCGCGCCGCCGGCCGGGCCG-3' (FRAG. NO:2066) (SEQ. ID NO:2077) '-CBGGCCBGGGCGCGCCGCCGGCCGGGCCG-3' (FRAG. NO:2067) (SEQ. ID NO:2078) '-BGGCCBGGGCGCGCCGCCGGCCGGGCCG-3' (FRAG. NO:2068) (SEQ. ID NO:2079) '-GGCCBGGGCGCGCCGCCGGCCGGGCCG-3' (FRAG. NO:2069) (SEQ. ID NO:2080) '-GCCBGGGCGCGCCGCCGGCCGGGCCG-3' (FRAG. NO:2070) (SEQ. ID NO:2081) '-CCBGGGCGCGCCGCCGGCCGGGCCG-3' (FRAG. NO:2071) (SEQ. ID NO:2082) -CBGGGCGCGCCGCCGGCCGGGCCG-3' (FRAG. NO:2072) (SEQ. ID NO:2083) '-BGGGCGCGCCGCCGGCCGGGCCG-3' (FRAG. NO:2073) (SEQ. ID NO:2084) -GGGCGCGCCGCCGGCCGGGCCG-3' (FRAG. NO:2074) (SEQ. ID NO:2085) -GGCGCGCCGCCGGCCGGGCCG-3' (FRAG. NO:2075) (SEQ. ID NO:2086) -GCGCGCCGCCGGCCGGGCCG-3' (FRAG. NO:2076) (SEQ. ID NO:2087) '-CGCGCCGCCGGCCGGGCCG-3' (FRAG. NO:2077) (SEQ. ID NO:2088) '-GCGCCGCCGGCCGGGCCG-3' (FRAG. NO:2078) (SEQ. ID NO:2089) -CGCCGCCGGCCGGGCCG-3' (FRAG. NO:2079) (SEQ. ID NO:2090) '-GCCGCCGGCCGGGCCG-3' (FRAG. NO:2080) (SEQ. ID NO:2091) -CCGCCGGCCGGGCCG-3' (FRAG. NO:2081) (SEQ. ID NO:2092) '-CGCCGGCCGGGCCG-3' (FRAG. NO:2082) (SEQ. ID NO:2093) '-GCCGGCCGGGCCG-3' (FRAG. NO:2083) (SEQ. ID NO:2094) -CCGGCCGGGCCG-3' (FRAG. NO:2084) (SEQ. ID NO:2095) -CGGCCGGGCCG-3' (FRAG. NO:2085) (SEQ. ID NO:2096) -GGCCGGGCCG-3' (FRAG. NO:2086) (SEQ. ID NO:2097) '-GGGCGCBGGCTCCGCB-3' (FRAG. NO:2087) (SEQ. ID NO:2098) '-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2088) (SEQ. ID NO:2099) '-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCG-3' (FRAG. NO:2089) (SEQ. ID NO:2100) '-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCC-3' (FRAG. NO:2090) (SEQ. ID Nθ:2101) '-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCσCCCGGCC-3' (FRAG. NO:209I) (SEQ. ID NO:2102) '-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGC-3' (FRAG. NO:2092) (SEQ. ID NO:2103) '-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGG-3' (FRAG. NO:2093) (SEQ. ID NO:2104) '-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCG-3' (FRAG. NO:2094) (SEQ. ID NO:2105) '-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCC-3^, (FRAG. NO:2095) (SEQ. ID NO:2106) '-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCC-3' (FRAG. NO:2096) (SEQ. ID NO:2107) '-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGC-3' (FRAG. NO:2097) (SEQ. ID NO:2108) '-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCG-3' (FRAG. NO:2098) (SEQ. ID NO:2109) '-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCC-3' (FRAG. NO:2099) (SEQ. ID Nθ:2110) EPI-109 223

5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCC-3' (FRAG. Nθ:2100) (SEQ. ID Nθ:2111) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGC-3' (FRAG. Nθ:2101) (SEQ. ID NO:2112) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTG-3' (FRAG. NO:2102) (SEQ. ID NO:2113) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTT-3' (FRAG. NO:2103) (SEQ. ID NO:2114) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCT-3' (FRAG. NO:2104) (SEQ. ID NO:2115) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGC-3' (FRAG. NO:2105) (SEQ. ID NO:2116) S'-GGGCCCCTGGCTCGGCCCCGCGGCCCGG ' (FRAG. NO:2106) (SEQ. ID NO:2117) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCG-3' (FRAG. NO:2107) (SEQ. ID NO:2118) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCC-3' (FRAG. NO:2108) (SEQ. ID NO:2119) 5'-GGGCCCCTGGCTCGGCCCCGCGGCC-3' (FRAG. NO:2109) (SEQ. ID NO:2120) 5'-GGGCCCCTGGCTCGGCCCCGCGGC-3' (FRAG. Nθ:2110) (SEQ. ID NO:2121) 5'-GGGCCCCTGGCTCGGCCCCGCGG-3' (FRAG. Nθ:2111) (SEQ. ID NO:2122) 5'-GGGCCCCTGGCTCGGCCCCGCG-3' (FRAG. NO:2112) (SEQ. ID NO:2123) 5'-GGGCCCCTGGCTCGGCCCCGC-3' (FRAG. NO:2113) (SEQ. ID NO:2124) 5'-GGGCCCCTGGCTCGGCCCCG-3' (FRAG. NO:2114) (SEQ. ID NO:2125) 5'-GGGCCCCTGGCTCGGCCCC-3' (FRAG. NO:2115) (SEQ. ID NO:2126) 5'-GGGCCCCTGGCTCGGCCC-3' (FRAG. NO:2116) (SEQ. ID NO:2127) 5'-GGGCCCCTGGCTCGGCC-3' (FRAG. NO:2117) (SEQ. ID NO:2128) 5'-GGGCCCCTGGCTCGGC-3' (FRAG. NO:2118) (SEQ. ID NO:2129) 5'-GGGCCCCTGGCTCGG-3' (FRAG. NO:2119) (SEQ. ID NO:2130) 5'-GGGCCCCTGGCTCG-3' (FRAG. NO:2120) (SEQ. ID NO:2131) 5 -GGGCCCCTGGCTC-3' (FRAG. NO:2121) (SEQ. ID NO:2132) 5 -GGGCCCCTGGCT-3' (FRAG. NO:2122) (SEQ. ID NO:2133)

5 -GGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. O:2123) (SEQ. ID NO:2134) 5'-GCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2124) (SEQ. ID NO:2135) 5'-CCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2125) (SEQ. ID NO:2136) 5'-CCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2126) (SEQ. ID NO:2137) 5'-CCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2127) (SEQ. ID NO:2138) 5'-CTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2128) (SEQ. ID NO:2139) 5'-TGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2I29) (SEQ. ID NO:2140) 5'-GGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2130) (SEQ. ID NO:2141) S'-GCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG ' (FRAG. NO:2131) (SEQ. ID NO:2142) 5'-CTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2132) (SEQ. ID NO:2143) 5'-TCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2133) (SEQ. ID NO:2144) 5'-CGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2134) (SEQ. ID NO:2145) 5'-GGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2135) (SEQ. ID NO:2146) 5'-GCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2136) (SEQ. ID NO:2147) S'-CCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG ' (FRAG. NO:2137) (SEQ. ID NO:2148) 5'-CCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2138) (SEQ. ID !SO:2149) 5'-CCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2139) (SEQ. ID NO:2150) 5 -CGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2140) (SEQ. ID NO:2151) 5'-GCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2141) (SEQ. ID NO:2152) 5'-CGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2142) (SEQ. ID NO:2153) 5 -GGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2143) (SEQ. ID NO:2154) S'-GCCCGGCTTGCCCGCCCGGCCCGG^' (FRAG. NO:2144) (SEQ. ID NO:2155) 5'-CCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2145) (SEQ. ID NO:2156) 5 -CCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2146) (SEQ. ID NO:2157) 5 -CGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2147) (SEQ. ID NO:2158) 5'-GGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2148) (SEQ. ID NO:2159) 5'-GCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2149) (SEQ. ID NO:2160) 5 -CTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2150) (SEQ. ID NO:2161) 5'-TTGCCCGCCCGGCCCGG-3' (FRAG. NO:2151) (SEQ. ID NO:2162) 5'-TGCCCGCCCGGCCCGG-3' (FRAG. NO:2152) (SEQ. ID NO:2163) 5'-GCCCGCCCGGCCCGG-3' (FRAG. NO:2153) (SEQ. ID NO:2164) 5'-CCCGCCCGGCCCGG-3' (FRAG. NO:2154) (SEQ. ID NO:2165) 5 -CCGCCCGGCCCGG-3' (FRAG. NO:2155) (SEQ. ID NO:2166) 5 -CGCCCGGCCCGG-3' (FRAG. NO:2156) (SEQ. ID NO:2167) 5'-GCCCGGCCCGG-3' (FRAG. NO:2157) (SEQ. ID NO:2168)

5'-GGCGGGGGCGGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2158) (SEQ. ID NO:2169) 5'-GGCGGGGGCGGCGGCGCCTGGCTCGCCTBGGGCCC-3' (FRAG. NO:2159) (SEQ. ID NO:2170) 5'-GGCGGGGGCGGCGGCGCCTGGCTCGCCTBGGGCC-3' (FRAG. NO:2160) (SEQ. ID NO:2171) S'-GGCGGGGGCGGCGGCGCCTGGCTCGCCTBGGGC ' (FRAG. NO:2161) (SEQ. ID NO:2172) 5'-GGCGGGGGCGGCGGCGCCTGGCTCGCCTBGGG-3' (FRAG. NO:2162) (SEQ. ID NO:2173) 5'-GGCGGGGGCGGCGGCGCCTGGCTCGCCTBGG-3' (FRAG. NO:2163) (SEQ. ID NO:2174) S'-GGCGGGGGCGGCGGCGCCrcGCTCGCCTBG-S' (FRAG. NO:2164) (SEQ. ID NO:2175) EPI-109 224

5'-GGCGGGGGCGGCGGCGCCTGGCTCGCCTB-3' (FRAG. NO:2165) (SEQ. ID NO:2176) 5'-GGCGGGGGCGGCGGCGCCTGGCTCGCCT-3' (FRAG. NO:2166) (SEQ. ID NO:2177) 5'-GGCGGGGGCGGCGGCGCCTGGCTCGCC-3' (FRAG. NO:2167) (SEQ. ID NO:2178) 5'-GGCGGGGGCGGCGGCGCCTGGCTCGC-3' (FRAG. NO:2168) (SEQ. ID NO:2179) 5'-GGCGGGGGCGGCGGCGCCTGGCTCG-3' (FRAG. NO:2169) (SEQ. ID NO:2180) 5'-GGCGGGGGCGGCGGCGCCTGGCTC-3' (FRAG. NO:2170) (SEQ. ID NO:2181) 5 -GGCGGGGGCGGCGGCGCCTGGCT-3' (FRAG. NO:2171) (SEQ. ID NO:2082) 5'-GGCGGGGGCGGCGGCGCCTGGC-3' (FRAG. NO:2172) (SEQ. ID NO:2183) 5 -GGCGGGGGCGGCGGCGCCTGG-3' (FRAG. NO:2173) (SEQ. ID NO:2184) 5 -GGCGGGGGCGGCGGCGCCTG-3' (FRAG. NO:2174) (SEQ. ID NO:2185) 5 -GGCGGGGGCGGCGGCGCCT-3' (FRAG. NO:2175) (SEQ. ID NO:2186) 5 -GGCGGGGGCGGCGGCGCC-3' (FRAG. NO:2176) (SEQ. ID NO:2187) 5'-GGCGGGGGCGGCGGCGC-3' (FRAG. NO:2177) (SEQ. ID NO:2188) 5 -GGCGGGGGCGGCGGCG-3' (FRAG. NO:2178) (SEQ. ID NO:2189) 5 -GGCGGGGGCGGCGGC-3' (FRAG. NO:2179) (SEQ. ID NO:2190) 5 -GGCGGGGGCGGCGG-3' (FRAG. NO:2180) (SEQ. ID NO:2191) 5 -GGCGGGGGCGGCG-3' (FRAG. NO:2181) (SEQ. ID NO:2192) 5 -GGCGGGGGCGGC-3' (FRAG. NO:2182) (SEQ. ID NO:2193) 5'-GGCGGGGGCGG-3' (FRAG. NO:2183) (SEQ. ID NO:2194)

5'-GCGGGGGCGGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2184) (SEQ. ID NO:2195) S -CGGGGGCGGCGGCGCCTGGCTCGCCTBGGGCCCC ' (FRAG. NO:2185) (SEQ. ID NO:2196) 5'-GGGGGCGGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2186) (SEQ. ID NO:2197) S -GGGGCGGCGGCGCCTGGCTCGCCTBGGGCCCC ' (FRAG. NO:2187) (SEQ. ID NO:2198) 5'-GGGCGGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2188) (SEQ. ID NO:2199) 5'-GGCGGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2I89) (SEQ. ID NO:2200) 5'-GCGGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2190) (SEQ. ID NO:2201) 5'-CGGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2191) (SEQ. ID NO:2202) 5'-GGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2192) (SEQ. ID NO:2203) 5'-GCGGCGCCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2193) (SEQ. ID NO:2204) 5^,-CGGCGCCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2194) (SEQ. ID NO:2205) 5'-GGCGCCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2195) (SEQ. ID NO:2206) 5 -GCGCCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2196) (SEQ. ID NO:2207) 5'-CGCCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2197) (SEQ. ID NO:2208) 5'-GCCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2198) (SEQ. ID NO:2209) 5'-CCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2199) (SEQ. ID NO:2210) 5'-CTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2200) (SEQ. ID NO:2211) 5'-TGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2201) (SEQ. ID NO:2212) S'-GGCTCGCCTBCGGCCCC ' (FRAG. NO:2202) (SEQ. ID NO:2213) 5'-GCTCGCCTBGGGCCCC-3' (FRAG. NO:2203) (SEQ. ID NO:2214) 5'-CTCGCCTBGGGCCCC-3' (FRAG. NO:2204) (SEQ. ID NO:2215) 5 -TCGCCTBGGGCCCC-3' (FRAG. NO:2205) (SEQ. ID NO:2216) 5 -CGCCTBGGGCCCC-3' (FRAG. NO:2206) (SEQ. ID NO:2217) S'-GCCTBGGGCCCC ' (FRAG. NO:2207) (SEQ. ID NO:2218) 5 -CCTBGGGCCCC-3' (FRAG. NO:2208) (SEQ. ID NO:2219) 5 -CTBGGGCCCC-3' (FRAG. NO:2209) (SEQ. ID NO:2220) 5 -GGGTGGGCBCGGCGGCC-3' (FRAG. NO:2210) (SEQ. ID NO:2221) S'-GGTCGGCGBBGBGCTCGTCGTGGC ' (FRAG. NO:2211) (SEQ. ID NO:2222) S'-GGTCGGCGBBGBGCTCGTCGTGG ' (FRAG. NO:2212) (SEQ. ID NO:2223) 5'-GGTCGGCGBBGBGCTCGTCGTG-3' (FRAG. NO:2213) (SEQ. ID NO:2224) 5 -GGTCGGCGBBGBGCTCGTCGT-3' (FRAG. NO:2214) (SEQ. ID NO:2225) S'-GGTCGGCGBBCBGCTCGTCG ' (FRAG. NO:2215) (SEQ. ID NO:2226) 5'-GGTCGGCGBBGBGCTCGTC-3' (FRAG. NO:2216) (SEQ. ID NO:2227) 5 -GGTCGGCGBBGBGCTCGT-3' (FRAG. NO:2217) (SEQ. ID NO:2228) 5 -GGTCGGCGBBGBGCTCG-3' (FRAG. NO:2218) (SEQ. ID NO:2229) 5'-GGTCGGCGBBGBGCTC-3' (FRAG. NO:2219) (SEQ. ID NO:2230) 5 -GGTCGGCGBBGBGCT-3' (FRAG. NO:2220) (SEQ. ID NO:2231) 5'-GGTCGGCGBBGBGC-3' (FRAG. NO:2221) (SEQ. ID NO:2232) 5 -GGTCGGCGBBGBG-3' (FRAG. NO:2222) (SEQ. ID NO:2233) 5 -GGTCGGCGBBGB-3' (FRAG. NO:2223) (SEQ. ID NO:2234) 5'-GGTCGGCGBBG-3' (FRAG. NO:2224) (SEQ. ID NO:2235) 5'-GTCGGCGBBGBGCTCGTCGTGGC-3' (FRAG. NO:2225) (SEQ. ID NO:2236) 5'-TCGGCGBBGBGCTCGTCGTGGC-3' (FRAG. NO:2226) (SEQ. ID NO:2237) 5'-CGGCGBBGBGCTCGTCGTGGC-3' (FRAG. NO:2227) (SEQ. ID NO:2238) 5 -GGCGBBGBGCTCGTCGTGGC-3' (FRAG. NO:2228) (SEQ. ID NO:2239) 5'-GCGBBGBGCTCGTCGTGGC-3' (FRAG. NO:2229) (SEQ. ID NO:2240) EPI-109 225

5'-CGBBGBGCTCGTCGTGGC-3' (FRAG. NO:2230) (SEQ. ID NO:2241)

5'-GBBGBGCTCGTCGTGGC-3' (FRAG. NO:2231) (SEQ. ID NO:2242)

5 -BBGBGCTCGTCGTGGC-3' (FRAG. NO:2232) (SEQ. ID NO:2243)

5'-BGBGCTCGTCGTGGC-3' (FRAG. NO:2233) (SEQ. ID NO:2244)

5'-GBGCTCGTCGTGGC-3' (FRAG. NO:2234) (SEQ. ID NO:2245)

5'-BGCTCGTCGTGGC-3' (FRAG. NO:2235) (SEQ. ID NO:2246)

S'-GCTCGTCGTGGC ' (FRAG. NO:2236) (SEQ. ID NO:2247)

S'-CTCGTCGTGGC-S' (FRAG. NO:2237) (SEQ. ID NO:2248)

5 -TCGTCGTGGC-3' (FRAG. NO:2238) (SEQ. ID NO:2249)

5'-GGGGCCCCGCGCCGCCCGCC-3' (FRAG. NO:2239) (SEQ. ID NO:2250)

5'-GGGGCCCCGCGCCGCCCGC-3' (FRAG. NO:2240) (SEQ. ID NO:2251)

5 -GGGGCCCCGCGCCGCCCG-3' (FRAG. NO:2241) (SEQ. ID NO:2252)

5'-GGGGCCCCGCGCCGCCC-3' (FRAG. NO:2242) (SEQ. ID NO:2253)

5 -GGGGCCCCGCGCCGCC-3' (FRAG. NO:2243) (SEQ. ID NO:2254)

5 -GGGGCCCCGCGCCGC-3' (FRAG. NO:2244) (SEQ. ID NO:2255)

5 -GGGGCCCCGCGCCG-3' (FRAG. NO:2245) (SEQ. ID NO:2256)

5 -GGGGCCCCGCGCC-3' (FRAG. NO:2246) (SEQ. ID NO:2257)

5'-GGGGCCCCGCGC-3' (FRAG. NO:2247) (SEQ. ID NO:2258)

5'-GGGCCCCGCGCCGCCCGCC-3' (FRAG. NO:2248) (SEQ. ID NO:2259)

5 -GGCCCCGCGCCGCCCGCC-3' (FRAG. NO:2249) (SEQ. ID NO:2260)

5 -GCCCCGCGCCGCCCGCC-3' (FRAG. NO:2250) (SEQ. ID NO:2261)

5 -CCCCGCGCCGCCCGCC-3' (FRAG. NO:2251) (SEQ. ID NO:2262)

5 -CCCGCGCCGCCCGCC-3' (FRAG. NO:2252) (SEQ. ID NO:2263)

5 -CCGCGCCGCCCGCC-3' (FRAG. NO:2253) (SEQ. ID NO:2264)

5 -CGCGCCGCCCGCC-3' (FRAG. NO:2254) (SEQ. ID NO:2265)

5 -GCGCCGCCCGCC-3' (FRAG. NO:2255) (SEQ. ID NO:2266)

5 -CGCCGCCCGCC-3' (FRAG. NO:2256) (SEQ. ID NO:2267)

5 -GCCGCCCGCC-3' (FRAG. NO:2257) (SEQ. ID NO:2268)

5 -GGGGCGCGCGGGGCCGCCGGG-3' (FRAG. NO:2258) (SEQ. ID NO:2269)

5 -GGCGGGGBGCGGCBGGGCCCGGGCCC-3' (FRAG. NO:2259) (SEQ. ID NO:2270)

5'-GGCGCGTCGCCGTCGCCCCBGTCGGGCTCGCGC-3^, (FRAG. NO:2260) (SEQ. ID NO:2271)

5'-GCGCGGGCBBCBGCGBGCCGGGCGCG-3' (FRAG. NO:2261) (SEQ. ID NO:2272)

5'-GCGCBCGGGCCCBCCTGCGCGGGC-3' (FRAG. NO:2262) (SEQ. ID NO:2273)

5'-GGGCGGGGTGGGCTGCCCTGCGGCCGCC-3' (FRAG. NO:2263) (SEQ. ID NO:2274)

5'-GGGCTGCTGCGCGGCGGCTCCGGCGA-3^, (FRAG. NO:2264) (SEQ. ID NO:2275)

5'-CTCCCGGGCGGGGCCGGGCGCGGGG-3' (FRAG. NO:2265) (SEQ. ID NO:2276)

5'-GGGCTGCCGCGGTCCGGGCCCCTCTTGCCGGCG-3^, (FRAG. NO:2266) (SEQ. ID NO:2277)

5'-GCGCTCGCGCCGCTGCCGG-3' (FRAG. NO:2267) (SEQ. ID NO:2278)

5'-GCGCCGCTTGGCCTTGTCGCGGC-3' (FRAG. NO:2268) (SEQ. ID NO:2279)

5'-GCTGCTCCBCGCGCTGG-3' (FRAG. NO:2269) (SEQ. ID NO:2280)

5 -GCCGGBGGCCGGCCBGGTCCCGCG-3' (FRAG. NO:2270) (SEQ. ID NO:2281)

5 -CCCGGCGGCCGGCBGGBBGGGCGGGCTGGGC-3' (FRAG. NO:2271) (SEQ. ID NO:2282)

5'-GTCTCTCCCGCCCCGGCCGCGCG-3' (FRAG. NO:2272) (SEQ. ID NO:2283)

5'-GGGCGTCCGCTCCGGGCCGTCGGG-3' (FRAG. NO:2273) (SEQ. ID NO:2284)

5'-GCGGGCACGCGGCGGCTCTGGCGTCGGC-3' (FRAG. NO:2274) (SEQ. ID NO:2285)

Bradykinin Receptor Nucleic Acids and Antisense Oligonucleotide Fragments

5'-GGTGBCBTTG BGCBTGTCGG CGCGGTCCCG TTBBGBGTGG GCCCGCCAGC CCAGCCACTC CACTTGGGGG CGGGTGGCCA

GCACGAACAG CACCCAGAGG AAGGGGGGCG GCCCAGAAGG GCAGCCCGCA GGCCAGGATC AGGTCTGCTG

CGGCCGGAGA TAATGGCATT CACCACGCGG CGGCCCAGCG CACGCCGCGC ATCCGGCCCG GGTTCTGACC TGCAGCCCCC

GTCTCCTTGG CATTCCTGGG CCCCAGTCAC TCCTCTCCCT GCCCCCCTTG CTGGGGCAGG GACGGGGTG BCBTTGBGCB

TGTCGGCGCG GTCCCGTTBB GBGTGGGCCC GCCAGCCCAG CCACTCCACT TGGGGGCGGG TGGCCAGCAC GAACAGCACC

CAGAGGAAGG GGGGCGGCCC AGAAGGGCAG CCCGCAGGCC AGGATCAGGT CTGCTGCGGC CGGAGATAAT GGCATTCACC

ACGCGGCGGC CCAGCGCACG CCGCGCATCC GGCCCGGGTT CTGACCTGCA GCCCCCGTCT CCTTGGCATT CCTGGGCCCC

AGTCACTCCT CTCCCTGCCC CCCTTGCTGG GGCAGGGACG GCCGTGTTGT CBGTGGTGCT GCCCGTTTGB GGTBTGGCGC

TCCBCCBBTT CCCTTTTCTC CTTGTTTTCC GTTTCTCTTG CCGTCTGTGG TT CAGATTCACA AACTGCAGGA CTGGGCAGGG

AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC

CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT

GCCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA

GCATTACTGT TCTTATTTGC TGCCACACCT GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA

GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC

CAGCTTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT CTTTAATCTA TTCAGCTAGA ACTTTGAAGG

ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT

CACTGATGGA CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA TTGAGCACTT GCTGTATATG CAGTATTGAG

CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCTTGAAGG AACTCAAAGA CTCAAGTGGG AACGACTGGG

CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC

CAAGGTTCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTT TTATGTAACA TGAAGTCGTT EPI-109 226

GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC GGTGTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTT CCACCTGTCA TTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCATTTGGAG AGAAGGCCAT GTCTTCAAAG TCTGATTTGT GATGAGGCAG AGGAAGATAT TTCTAATCGG TCTTGCCCAG AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG GCCTGCTCAG GGACTGTTCC TGTCTCAGCA ACCAAGGGAT TGTTCCTGTC AATCAATGGT TTATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGTGT TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT AAATGAATAT TTATTAGCTG GTTGGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA ACCTAGAAGG GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGTTA GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATTTACAT GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAAT TTTAAAGCAA AAGCGTGAAA AAAAAGATTC CCTCCTTACC CCCAACCCAC TCTTTTTTCC CACCACCCAC TCTCCTCTGC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATTTAGTATT AGTATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC TGTGTTTTGT CACACAGGGC AGTCATTCAG CACCAGAGCA CGTGATGGTC TGAGACTCTC TTAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC TGTCCTGTGA AAGACTCAAT GAGCTGTTAT GTTGTAAACA GGAAGCATTT CACATCCAAA CGAGAAAATC ATGTAAACAT GTGTCTTTTC TGTAGAGCAT AATAAATGGA TGAGGTTTTT GCAAAAAAAA AAAAAAAAA AAATGATAGA CCGTCAATAA TTTGTTAAAT GCTTTTTAAA ATGAATGCTT TAAGCCGGGT GCAGTGCCTC ACATCTGTAA TCCCAGCACT TTGGAGCCGA GCGGGTGGAT TGTGTGAGGT CAGGAGTTCG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCTCTACC AAAAATACAA AAATTAGCCA GGCATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG GAGAATCGCT TGAACCCGGG AGGCAAGGTT GCAGTGAGCC AAGATTACGC CATTGTACTC CAGCCTGGGT GACAGAGAGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATTAC GCTTCAAACA CATGATCTCT CACCACTGTT GAATTTTCTT TCTATGAGCC CAGGAGGGCC TCTCAGAGAG GAAAGCTCCT AGGTCTTCCT TTCCCTCTGC AAACTCCCTG CCTTGAAGGT TCAGAAGGAC TGTGCGTGCT CGTTGCATCC TTTGCAAGTG TCCAAACCCT GATCCCAGCT GTGCTTAGGG GTTCCTGCAA ACCTTTTCCA GGTGTTAATT ACCTCCCACT TCATTTCCTG TTTACCAACT CAGCTTTTTG TTTTAGTGTG TTTGAATTCC CTGAACTGAC CGTTGTCTGA TCTCCACCTC CCAACTGAAT TAGGGGAGCT GGGCTTCTGG AAACCCAGGT GCCGGGTGTT GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACACACAC ACCCACATAC CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TTGGACATGC ATAGACCACA GCTTTCCACA CCCTTCCTAG ACAGGGGTCA CTTGGTATCC TGGAGAGAGT GTGAAGTCCT GGAATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA CAAGTCACCA CCAACCCATC TGCGCCTTGT TTACCTCCTC TGTGAGGCAA GCACAGAGCC CATGCCTGCC CCCCTGGATG GGAGTGATGT GAAACTTGAA GGGCGGTCAG AGCAAGGGTC GGGAATGGAA GGCCCTTGGG AAAAAAGGCC CTTTCAACTA GGGGCACAGA GGAGGCCCTG GGCTGAGAAC TTGACAGCAC CTTGTAATTG GTAAGCCAAG CCCGAAGGGA CTGGAAATAC TCAGATGTGT CTGTCTCCCT TATTAGGTTC AAAGTCCCTC AAGACCCTGT CTCCATCACA GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGACCCAA CCAGCCCTAT GGGGTCGCAT CCCCACCTGC CTGGAATTCT CCAAAGAACC TCCCCTTTAA CAGTTCCAGC CTTTAACAGT TCCAGTCTAA ACACATGACC TTTCTCCTCT AAATCAGCCC CCCATCTCTG CCTTTGCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC CCATCCATGT CCAATCAAGC ACTAGGCATG TCAGGTTTAC CCTCTAAACT CCTCTGGAAT CCAGTCTCTC AGTCTCCATC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCTTGCTTC CACTCTACCC CCACTGCAGT CCTGACTTCC TGAGCAGCAG CCAGGGCCTA ATCGATATTC ACACCAAGCG CCAACCTGAC TGAGATATCC TCCTGCACCA TCATCCCTCC ACCCTGTTTA GTTCTGCTCA CCCTCAGTGT TCTCATCAAT AATCCACTCC CCTCACAGGC GCGTTTGGGA CCCCATGTTC TATGCTCTCA CAGGACCTTT TGCTTGATTT TTCACTGTAC TTAGGTCAGT TTGCAGTTAT TAAGTGACTG AGCAATGTCT GGCTTCTCCA GTAGACTGTC AGCTCCTAGC CATTGTATAC CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG AGTCAGGGAC TCAGCAGTCT CCATTTCTCC GCCCTGCTGG AGAATGCGTG TATTTGGCAA TCCCCAGCCC CTGTGCCATC TAACCATCTT TTCTTCTCTG TTCAGCCCAG GTGTGGCCTC ACTCACATCC CACTCTGAGT CCAAATGTTC TCTCCCTGGA AGATATCAAT GTTTCTGTCT GTTCGTGAGG ACTCCGTGCC CACCACGGCC TCTTTCAGGT GAGTCAAAGG GATTCCTCAG TTCACTAGTT AGGGGAGGTG GGCAGACACC CTGGAGAACT CCCTGGAAAG CTCAACTCTC ATGCCCCGGA CAACAGTTGA AGGAACCATG GTGATGTTAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGTTG GAATCTTGGG AGCAGAGGGA ATGTTCTGTG GTCT AGAGGA AGAGGGGCTC AGGGAGGAGA AGGGCACATT CCTGGTTGTT ATATGTTTCT ATCTATCCCA GATGAACTTG GAAGTGAAGG GAAGAGAGTT AAACATTAAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC CTTGGAAACA AAATATCTCC AACACATGGC TGACATTTGG TGGGAGATCA GAACACCCTA AAGAGAGAAT TTAAGGGGAG GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC AGAGGATAGG GAGATCTGTT CTTGGGGACA GCATTTGCAA GAAACAAGGC TGAGGGGTCC ACTCCAACCT CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGGCCAT CTCAGCTGGG GCCACAGTGC ACTGGACCTA TAGTTTCCAA TTCCGCACTC AGCAGGCATC TTTCTGATGA TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCTTGGCT ACTGTCTTGC TGAGAAATTT ATAAGCAGCA TCTGGTGCTA TACTTTGGTC TCTAGTGAGT TAGCTCATGA AAGATGATAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GGTTTTCTGT AGCTACAGAA ATGGGGTTGA GGGTTGGACC AAGGGACTAC CCAGGGGAAG TCTTACCTTC AGAGGACTCT GGAAAGGAGG CTGCAAGTTT TCATGGGTCA AGAATTCAGA GCCCAGTAGA GACAGCTTAT CTCTGTTCCA AGATGTCTGG GGCCTTGGTT GGAAGATTCA AAGGCTAGGA AACCAGGAGC CACCAAAAGC GTAACTGGGG CCAGAGGATC CACTTTCAAG GTGGCAAGTT GGTTCCCCCC ATGTGGCTGC TTGAGTATCC TCACATGGCG GCTCACATCC TTCCAAGTAA GCAATGCAAA AGGCCAAGAA AGATGCTGCA AAGATGTTAT GACCTAGCCT CAGAAATCAC ACACCATCCC TGCCACCATT AGTAAGAAGT CCAGCCCACG TCCAGGAGAA GAGGAAGCAG ATTCCTCCTT TTGAAATGAA GAATATCAAG TAATTCGGGG GGCATATGAA AGCCACCACA CACCACAGGG ATCTTTTTAG AGCATACTTC TTATACCATC ACTGTAGTTC CTTAAGACTC AGGGGCAAAG CCTCACTTCC TTAGCACCCA GTGAAGACCA CGCTTACTCC CTCACTCAAC CTCTTGCTAC TTCCCACCTC TCCTGTCCAA CATCTAGTGT CACTTTCCAG AACATACCAA CAGCTTCCCC AGTTCTGTGC CTCTGCTCAG GCTGTTCCCC CTGCCTGGTC CACTTGTCCT CCTTCTTGTC CGGTCAAAAT GCTTCTTATC CTTCAAGACC CAGCTCTAGA GTCACCTCCA ACCCCTTACC CACCAGCCCC CTCTCCAAGT CTGTGTCCCA CAACCCCCCT GCTCCCTCCA EPI-109 227

GGGCACCCTC CACCCTCTGG GCCACAGTTG TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG GTGTCTTCTT TGTGTTCTTG CACTCAGGGC AGAGCTCAGC ACAGAGCAGA CGCTCAAAAA ACATTTAAAG GATAGAAGCA TTGATTTGTG GGTCCCCCAG TCTGGCTCCA GGATGCCAGC CAGCTGCTCC TAGAAGCAAA CGGACTTTTC CTGGGAAATC CCAGAGGTGA TGATCAGTAA TCTCTCCCGT GACTCGTAGT TCAGCTCTTC CTCCATGAGC CTGACTATCA GTGGACCTTC CAGAAAGAGC CCCTTTTCCT TCTCTCACCC ACAGCACAGG GCACTGGGAA AATGCCCAAT GAGTCCTGCC TCTGGGTTGT GCTTTGGACT TTTCAGTGTG TCTCGCATCC ACTCTTCAAC TTGAATGTTG CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATTCAGGATG AGAGCAATAC CCTACTCCAA AGAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAATTTGC CCAAGACCAC ACAGCTAGGA GTGGAACTCA TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GGTAGAGATG AATTACAGCA ACAAGTCTAG AAAGGTGCCT GCCCTATGGT CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA GCCAGTGGGT TAAAGATGAG GTCACCAACA ACGGTGGTGT TGGAGTTTAC CACTGATAAT AAGGGTGCAA AATGTAAATT ACTAATGTTT ATTGAGCCTA GTGCAGTGCG TGGGGCATTT TGCACATTGT CTCTGATCCC TATGACAACC CTGAGAGGTA GTGGTTTTAA CTGCCATGTT ACAGGTGAGG TCATTGTGGT TCAAGGACGT TAAGTAACTT CCCCAGCGTG ACACGGCTTA TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT GGCTGCAAAG TCCCCACCCC CCTCGCCATC TGTATCCTCC AATCACTTCA GTGCTTTGCT GCATAGAAGG TAACGGAAAT CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCTC CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATT TTTCTCTTTT AATAAATTAA CTCACCCACC ACACGGCTTT GAGAGGCTCA AAGTTGACCA ACTCCCTTGG GAGGGCCCCG GTTGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC TTCAAGGAGG TCAAGGGTCC AACACTTGAG ATTGTTAGTG CTGTTGGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC CTCGAGATGA AGAACATGAG GCCCCCGTTT AGAACCAAGG ATCAGAGGGG GCTCTGTAAG ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT CGGCTTCTCC TTGTCCTGGC TGGTTGTCCT TAACCCCTGT CTCCTTCTGG ACCAGTTTTT GTCCTTCCCT TGTGACCGCT GAGGGGTAAC AGCCTCTTTC CACTTTCTTT CAGCGCCGAC ATGCTCAATG TCACCTTGCA AGGGCCCACT CTTAACGGGA CCTTTGCCCA GAGCAAATGC CCCCAAGTGG AGTGGCTGGG CTGGCTCAAC ACCATCCAGC CCCCCTTCCT CTGGGTGCTG TTCGTGCTGG CCACCCTAGA GAACATCTTT GTCCTCAGCG TCTTCTGCCT GCACAAGAGC AGCTGCACGG TGGCAGAGAT CTACCTGGGG AACCTGGCCG CAGCAGACCT GATCCTGGCC TGCGGGCTGC CCTTCTGGGC CATCACCATC TCCAACAACT TCGACTGGCT CTTTGGGGAG ACGCTCTGCC GCGTGGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG CATCTGTTTC CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG ATGCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTGGGGGTG TACGCTGCTC CTGAGCTCAC CCATGCTGGT GTTCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC GTCACCGCTT GTGTCATCAG CTACCCATCC CTCATCTGGG AAGTGTTCAC CAACATGCTC CTGAATGTCG TGGGCTTCCT GCTGCCCCTG AGTGTCATCA CCTTCTGCAC GATGCAGATC ATGCAGGTGC TGCGGAACAA CGAGATGCAG AAGTTCAAGG AGATCCAGAC GGAGAGGAGG GCCACGGTGC TAGTCCTGGT TGTGCTGCTG CTATTCATCA TCTGCTGGCT GCCCTTCCAG ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGGCATCC TCTCCAGCTG CCAGGACGAG CGCATCATCG ATGTAATCAC ACAGATCGCC TCCTTCATGG CCTACAGCAA CAGCTGCCTC AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTTCCGAA AGAAGTCTTG GGAGGTGTAC CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA TTCAGATGGA GAACTCCATG GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTGCA GGACTGGGCA GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA ATTTCTGTAA GGATTGAGGG ACAGTTGCTT TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG AAATGAGTTG ATGTCTCCGG TAAAACACCG GAGACTAATT CCTGCCCTGC CCAATTTTGC AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA ACAGCATTAC TGTTCTTATT TGCTGCCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGTG GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA CTGAGCTTCC CTCCCGTGTG TTCTCCGTCC CTGCCCCAGC AAGACAACTT AGATCTCCAG GAGAACTGCC ATCCAGCTTT GGTGCAATGG CTGAGTGCAC AAGTGAGTTG TTGCCCTGGG TTTCTTTAAT CTATTCAGCT AGAACTTTGA AGGACAATTT CTTGCATTAA TAAAGGTTAA GCCCTGAGGG GTCCCTGATA ACAACCTGGA GACCAGGATT TTATGGCTCC CCTCACTGAT GGACAAGGAG GTCTCTGCCA AAGAAGAATC CAATAAGCAC ATATTGAGCA CTTGCTGTAT ATGCAGTATT GAGCACTGTA GGCAAGAGGG AAGAAAGAGA AGGAGCCATC TCCATCTTGA AGGAACTCAA AGACTCAAGT GGGAACGACT GGGCACTGCC ACCACCAGAA AGCTGTTCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA TATGGACAGC AGAAGGGGGA GCCAGGTTCC AGCTCACCAA TACTATTGCA CACCACCTGT CCTGCCTC GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGCCC ATGCCGCTTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTTTCCCTG TGGTCGTGGG GAGTT GAGCTCTTCA ATATTTTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA CACACCTTTT CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA CTGGCAAGTC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGTTTCC CTGTCTCCAT GATGATGGGA TCAGGCTTGA TTGCTGGTTT GTAGGCTTGT TATGAATCAA GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTTCC CCAGATCCAC TGGGCCCACT CTTATCTGTT CTCTTCTGAA GGAAGGGTTT TAAGGCTTCA AAAAAAAATG TTTTGAAAGT CCCTGCCCTT TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAAAC TGAGAAAGCC AGCCTGAGCC TTGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGCC ACTGTCGCCC TTGGGAGCCG TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTTTA CACCTTCCGC GTAAACGCCC ACTGTTTACA TCCAAAACTC AGACACAAAA TAACCACCTC AAGAAGATAA ATAATGATAA GAAATAAATG TTACGCGAGG CAAATTTATT CACATGGGGC TTCCCAGGCC ACTTTGTGGT CAGCCGGGAG GGACGTTTTT GCCGTCCCAC GACTCCAACG GGCAGCCGGG CCTACGCAAA CATGGAAATC TTCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCTT CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCTTCAAAG ATGAGCTGTT CCCGCCGCCA CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGAGAAG GTGGGTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AGTTGGGAAA AGTTCCCTTC CTTCCGGAGG GAGG CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT GCCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA EPI-109 228

GCATTACTGT TCTTATTTGC TGCCACACCT GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAGCTTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT CTTTAATCTA TTCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA TTGAGCACTT GCTGTATATG CAGTATTGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCTTGAAGG AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTT TTATGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC GGTGTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTT CCACCTGTCA TTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCATTTGGAG AGAAGGCCAT GTCTTCAAAG TCTGATTTGT GATGAGGCAG AGGAAGATAT TTCTAATCGG TCTTGCCCAG AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG GCCTGCTCAG GGACTGTTCC TGTCTCAGCA ACCAAGGGAT TGTTCCTGTC AATCAATGGT TTATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGTGT TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT AAATGAATAT TTATTAGCTG GTTGGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA ACCTAGAAGG GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGTTA GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATTTACAT GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAAT TTTAAAGCAA AAGCGTGAAA AAAAAGATTC CCTCCTTACC CCCAACCCAC TCTTTTTTCC CACCACCCAC TCTCCTCTGC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATTTAGTATT AGTATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC TGTGTTTTGT CACACAGGGC AGTCATTCAG CACCAGAGCA CGTGATGGTC TGAGACTCTC TTAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC TGTCCTGTGA AAGACTCAAT GAGCTGTTAT GTTGTAAACA GGAAGCATTT CACATCCAAA CGAGAAAATC ATGTAAACAT GTGTCTTTTC TGTAGAGCAT AATAAATGGA TGAGGTTTIT GCAAAAAAAA AAAAAAAAA AAATGATAGA CCGTCAATAA TTTGTTAAAT GCTTTTTAAA ATGAATGCTT TAAGCCGGGT GCAGTGCCTC ACATCTGTAA TCCCAGCACT TTGGAGCCGA GCGGGTGGAT TGTGTGAGGT CAGGAGTTCG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCTCTACC AAAAATACAA AAATTAGCCA GGCATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG GAGAATCGCT TGAACCCGGG AGGCAAGGTT GCAGTGAGCC AAGATTACGC CATTGTACTC CAGCCTGGGT GACAGAGAGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATTAC GCTTCAAACA CATGATCTCT CACCACTGTT GAATTTTCTT TCTATGAGCC CAGGAGGGCC TCTCAGAGAG GAAAGCTCCT AGGTCTTCCT TTCCCTCTGC AAACTCCCTG CCTTGAAGGT TCAGAAGGAC TGTGCGTGCT CGTTGCATCC TTTGCAAGTG TCCAAACCCT GATCCCAGCT GTGCTTAGGG GTTCCTGCAA ACCTTTTCCA GGTGTTAATT ACCTCCCACT TCATTTCCTG TTTACCAACT CAGCTTTTTG TTTTAGTGTG TTTGAATTCC CTGAACTGAC CGTTGTCTGA TCTCCACCTC CCAACTGAAT TAGGGGAGCT GGGCTTCTGG AAACCCAGGT GCCGGGTGTT GCAGAGTGGC TGAAACCTGG GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACACACAC ACCCACATAC CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TTGGACATGC ATAGACCACA GCTTTCCACA CCCTTCCTAG ACAGGGGTCA CTTGGTATCC TGGAGAGAGT GTGAAGTCCT GGAATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA CAAGTCACCA CCAACCCATC TGCGCCTTGT TTACCTCCTC TGTGAGGCAA GCACAGAGCC CATGCCTGCC CCCCTGGATG GGAGTGATGT GAAACTTGAA GGGCGGTCAG AGCAAGGGTC GGGAATGGAA GGCCCTTGGG AAAAAAGGCC CTTTCAACTA GGGGCACAGA GGAGGCCCTG GGCTGAGAAC TTGACAGCAC CTTGTAATTG GTAAGCCAAG CCCGAAGGGA CTGGAAATAC TCAGATGTGT CTGTCTCCCT TATTAGGTTC AAAGTCCCTC AAGACCCTGT CTCCATCACA GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGACCCAA CCAGCCCTAT GGGGTCGCAT CCCCACCTGC CTGGAATTCT CCAAAGAACC TCCCCTTTAA CAGTTCCAGC CTTTAACAGT TCCAGTCTAA ACACATGACC TTTCTCCTCT AAATCAGCCC CCCATCTCTG CCTTTGCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC CCATCCATGT CCAATCAAGC ACTAGGCATG TCAGGTTTAC CCTCTAAACT CCTCTGGAAT CCAGTCTCTC AGTCTCCATC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCTTGCTTC CACTCTACCC CCACTGCAGT CCTGACTTCC TGAGCAGCAG CCAGGGCCTA ATCGATATTC ACACCAAGCG CCAACCTGAC TGAGATATCC TCCTGCACCA TCATCCCTCC ACCCTGTTTA GTTCTGCTCA CCCTCAGTGT TCTCATCAAT AATCCACTCC CCTCACAGGC GCGTTTGGGA CCCCATGTTC TATGCTCTCA CAGGACCTTT TGCTTGATTT TTCACTGTAC TTAGGTCAGT TTGCAGTTAT TAAGTGACTG AGCAATGTCT GGCTTCTCCA GTAGACTGTC AGCTCCTAGC CATTGTATAC CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG AGTCAGGGAC TCAGCAGTCT CCATTTCTCC GCCCTGCTGG AGAATGCGTG TATTTGGCAA TCCCCAGCCC CTGTGCCATC TAACCATCTT TTCTTCTCTG TTCAGCCCAG GTGTGGCCTC ACTCACATCC CACTCTGAGT CCAAATGTTC TCTCCCTGGA AGATATCAAT GTTTCTGTCT GTTCGTGAGG ACTCCGTGCC CACCACGGCC TCTTTCAGGT GAGTCAAAGG GATTCCTCAG TTCACTAGTT AGGGGAGGTG GGCAGACACC CTGGAGAACT CCCTGGAAAG CTCAACTCTC ATGCCCCGGA CAACAGTTGA AGGAACCATG GTGATGTTAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGTTG GAATCTTGGG AGCAGAGGGA ATGTTCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA AGGGCACATT CCTGGTTGTT ATATGTTTCT ATCTATCCCA GATGAACTTG GAAGTGAAGG GAAGAGAGTT AAACATTAAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC CTTGGAAACA AAATATCTCC AACACATGGC TGACATTTGG TGGGAGATCA GAACACCCTA AAGAGAGAAT TTAAGGGGAG GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC AGAGGATAGG GAGATCTGTT CTTGGGGACA GCATTTGCAA GAAACAAGGC TGAGGGGTCC ACTCCAACCT CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGGCCAT CTCAGCTGGG GCCACAGTGC ACTGGACCTA TAGTTTCCAA TTCCGCACTC AGCAGGCATC TTTCTGATGA TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCTTGGCT ACTGTCTTGC TGAGAAATTT ATAAGCAGCA TCTGGTGCTA TACTTTGGTC TCTAGTGAGT TAGCTCATGA AAGATGATAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GGTTTTCTGT AGCTACAGAA ATGGGGTTGA GGGTTGGACC AAGGGACTAC CCAGGGGAAG TCTTACCTTC AGAGGACTCT GGAAAGGAGG CTGCAAGTTT TCATGGGTCA AGAATTCAGA GCCCAGTAGA GACAGCTTAT CTCTGTTCCA AGATGTCTGG GGCCTTGGTT GGAAGATTCA AAGGCTAGGA AACCAGGAGC CACCAAAAGC EPI-109 229

GTAACTGGGG CCAGAGGATC CACTTTCAAG GTGGCAAGTT GGTTCCCCCC ATGTGGCTGC TTGAGTATCC TCACATGGCG GCTCACATCC TTCCAAGTAA GCAATGCAAA AGGCCAAGAA AGATGCTGCA AAGATGTTAT GACCTAGCCT CAGAAATCAC ACACCATCCC TGCCACCATT AGTAAGAAGT CCAGCCCACG TCCAGGAGAA GAGGAAGCAG ATTCCTCCTT TTGAAATGAA GAATATCAAG TAATTCGGGG GGCATATGAA AGCCACCACA CACCACAGGG ATCTTTTTAG AGCATACTTC TTATACCATC ACTGTAGTTC CTTAAGACTC AGGGGCAAAG CCTCACTTCC TTAGCACCCA GTGAAGACCA CGCTTACTCC CTCACTCAAC CTCTTGCTAC TTCCCACCTC TCCTGTCCAA CATCTAGTGT CACTTTCCAG AACATACCAA CAGCTTCCCC AGTTCTGTGC CTCTGCTCAG GCTGTTCCCC CTGCCTGGTC CACTTGTCCT CCTTCTTGTC CGGTCAAAAT GCTTCTTATC CTTCAAGACC CAGCTCTAGA GTCACCTCCA ACCCCTTACC CACCAGCCCC CTCTCCAAGT CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC CACCCTCTGG GCCACAGTTG TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG GTGTCTTCTT TGTGTTCTTG CACTCAGGGC AGAGCTCAGC ACAGAGCAGA CGCTCAAAAA ACATTTAAAG GATAGAAGCA TTGATTTGTG GGTCCCCCAG TCTGGCTCCA GGATGCCAGC CAGCTGCTCC TAGAAGCAAA CGGACTTTTC CTGGGAAATC CCAGAGGTGA TGATCAGTAA TCTCTCCCGT GACTCGTAGT TCAGCTCTTC CTCCATGAGC CTGACTATCA GTGGACCTTC CAGAAAGAGC CCCTTTTCCT TCTCTCACCC ACAGCACAGG GCACTGGGAA AATGCCCAAT GAGTCCTGCC TCTGGGTTGT GCTTTGGACT TTTCAGTGTG TCTCGCATCC ACTCTTCAAC TTGAATGTTG CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATTCAGGATG AGAGCAATAC CCTACTCCAA AGAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAATTTGC CCAAGACCAC ACAGCTAGGA GTGGAACTCA TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GGTAGAGATG AATTACAGCA ACAAGTCTAG AAAGGTGCCT GCCCTATGGT CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA GCCAGTGGGT TAAAGATGAG GTCACCAACA ACGGTGGTGT TGGAGTTTAC CACTGATAAT AAGGGTGCAA AATGTAAATT ACTAATGTTT ATTGAGCCTA GTGCAGTGCG TGGGGCATTT TGCACATTGT CTCTGATCCC TATGACAACC CTGAGAGGTA GTGGTTTTAA CTGCCATGTT ACAGGTGAGG TCATTGTGGT TCAAGGACGT TAAGTAACTT CCCCAGCGTG ACACGGCTTA TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT GGCTGCAAAG TCCCCACCCC CCTCGCCATC TGTATCCTCC AATCACTTCA GTGCTTTGCT GCATAGAAGG TAACGGAAAT CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCTC CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATT TTTCTCTTTT AATAAATTAA CTCACCCACC ACACGGCTTT GAGAGGCTCA AAGTTGACCA ACTCCCTTGG GAGGGCCCCG GTTGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC TTCAAGGAGG TCAAGGGTCC AACACTTGAG ATTGTTAGTG CTGTTGGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC CTCGAGATGA AGAACATGAG GCCCCCGTTT AGAACCAAGG ATCAGAGGGG GCTCTGTAAG ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT CGGCTTCTCC TTGTCCTGGC TGGTTGTCCT TAACCCCTGT CTCCTTCTGG ACCAGTTTTT GTCCTTCCCT TGTGACCGCT GAGGGGTAAC AGCCTCTTTC CACTTTCTTT CAGCGCCGAC ATGCTCAATG TCACCTTGCA AGGGCCCACT CTTAACGGGA CCTTTGCCCA GAGCAAATGC CCCCAAGTGG AGTGGCTGGG CTGGCTCAAC ACCATCCAGC CCCCCTTCCT CTGGGTGCTG TTCGTGCTGG CCACCCTAGA GAACATCTTT GTCCTCAGCG TCTTCTGCCT GCACAAGAGC AGCTGCACGG TGGCAGAGAT CTACCTGGGG AACCTGGCCG CAGCAGACCT GATCCTGGCC TGCGGGCTGC CCTTCTGGGC CATCACCATC TCCAACAACT TCGACTGGCT CTTTGGGGAG ACGCTCTGCC GCGTGGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG CATCTGTTTC CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG ATGCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTGGGGGTG TACGCTGCTC CTGAGCTCAC CCATGCTGGT GTTCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC GTCACCGCTT GTGTCATCAG CTACCCATCC CTCATCTGGG AAGTGTTCAC CAACATGCTC CTGAATGTCG TGGGCTTCCT GCTGCCCCTG AGTGTCATCA CCTTCTGCAC GATGCAGATC ATGCAGGTGC TGCGGAACAA CGAGATGCAG AAGTTCAAGG AGATCCAGAC GGAGAGGAGG GCCACGGTGC TAGTCCTGGT TGTGCTGCTG CTATTCATCA TCTGCTGGCT GCCCTTCCAG ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGGCATCC TCTCCAGCTG CCAGGACGAG CGCATCATCG ATGTAATCAC ACAGATCGCC TCCTTCATGG CCTACAGCAA CAGCTGCCTC AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTTCCGAA AGAAGTCTTG GGAGGTGTAC CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA TTCAGATGGA GAACTCCATG GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTGCA GGACTGGGCA GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA ATTTGTGTAA GGATTGAGGG ACAGTTGCTT TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG AAATGAGTTG ATGTCTCCGG TAAAACACCG GAGACTAATT CCTGCCCTGC CCAATTTTGC AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA ACAGCATTAC TGTTCTTATT TCCTGCCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGTG GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA CTGAGCTTCC CTCCCGTGTG TTCTCCGTCC CTGCCCCAGC AAGACAACTT AGATCTCCAG GAGAACTGCC ATCCAGCTTT GGTGCAATGG CTGAGTGCAC AAGTGAGTTG TTGCCCTGGG TTTCTTTAAT CTATTCAGCT AGAACTTTGA AGGACAATTT CTTGCATTAA TAAAGGTTAA GCCCTGAGGG GTCCCTGATA ACAACCTGGA GACCAGGATT TTATGGCTCC CCTCACTGAT GGACAAGGAG GTCTGTGCCA AAGAAGAATC CAATAAGCAC ATATTGAGCA CTTGCTGTAT ATGCAGTATT GAGCACTGTA GGCAAGAGGG AAGAAAGAGA AGGAGCCATC TCCATCTTGA AGGAACTCAA AGACTCAAGT GGGAACGACT GGGCACTGCC ACCACCAGAA AGCTGTTCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA TATGGACAGC AGAAGGGGGA GCCAGGTTCC AGCTCACCAA TACTATTGCA CACCACCTGT CCTGCCTC CTGCAGAAAA CAGCCTGAGC TCCACCTCGG CTTCTCCTTG CCCTGGCTGG TTGTCCTTAA CCCCTGTCTC CTTCTGGACC AGTTTTTGTC CTTCCCTTGT GACCCTGAGG GGTAACAGCC TCTTTTCCAC TTTCTTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTT AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCCCC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTTTGTC CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC AACAACTTCG ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA TTCATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC TTCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG EPI-109 230

ACTAATTCCT GNCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGCAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAGCTTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT CTTTAATCTA TTCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA CAAGGGAGGT CTGTGCCAAA GAAGAATCCA ATAAGCACAT ATTGAGCACT TGCTGTATAT GCAGTATTGA GCACTGTAGG CAAGAGGGAA GAAAGAGAAG GAGCCATCTC CATCTTGAAG GAACTCAAAG ACTCAAGTGG GAACGACTGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTC TTCTGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG AGGTCTAGA TGATCCTATC ACAACCTGAG AGTAGTTTTT ACTCCATTTA CAGGTGAGGT CATTGTGGTT CAAGGACGTT AAGTAACTTC CCCAGCTCAC ACGGCTTATA AGTAAGGCAG CCAGGATGTG AACCCAGTAG GACTATCTGG CTGCAAAGTC CCCACCCTCC CTCGCCATCT GTATCCTCCA ATCATCTTCA GTGCTTTGCT GATAGAAGGT ACGGAAATAC GATGCCACAG ACTGTCCAGG AAGACAGAAA CTAGGCAGAT GGGCTGGCCA TGGTCTCCAA GCCAGACTGG AATCTCCAGG TCTGGAATGA TATCATTTTT CTCTTTTAAT AAATTAACTC ACCCACCACA CGGCTTTGAG AGGCTCAAAG GTGACCAACT CCCTTGGGAG GGCCCCGGTT GATAAGGAAG GAATGTGAAT CCTCCCATCA CGGAAGCTTC AAGGAGGTCA AGGGTCCAAC ACTTGAGATT GTTAGTGCTG TTGGTGGATA CTGCAGAATA TCCAGTGGAG CCTCAGATGA AGAACATGAG GCCCCGTTTA GATCCAAGGA TCAGAGGGGG CTCTGTAAGA CCCAGGGGAG TCAGGTGCAC TGGAGCGCGG GCTGCAGAAA ACAGCCTGAG CTCCACCTCG GCTTCTCCTT GCCCTGGCTG GTTGTCCTTA ACCCCTGTCT CCTTCTGGAC CAGTTTTTGT CCTTCCCTTG TGACCTGAGG GGTAACAGCC TCTTTTCCAC TTTCTTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTT AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCCCC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTTTGTC CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC AACAACTTCG ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA TTCATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC TTCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTGTTGA TGTCTCCGGT AAAACACCGG AGACTAATTC CTGCCCTGCC CAATTTTCGA GGGAGCATGG CTGTGAGGAT GGGGTGAACT CACGCACAGC CAAGGACTCC AAAATCACAA CAGCATTACT GTTCTTATTT GCTGCCACAC CTGAGCCAGC CTGCTCCTTC CCAGGAGTGG AGGAGGCCTG GGGGAGGGAG AGGAGTGACT GAGCTTCCCT CCCGTGTGTT CTCCGTCCCT GCCCCAGCAA GACAACTTAG ATCTCCAGGA GAACTGCCAT CCACGTTTGG TGCAATGGCT GAGTGCACAA GTGAGTTGTT GCCCTGGGTT TCTTTAATCT ATCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTTGATAAC AACCTGGAGA CCAGGATTTT ATGGCTCCCC TCACTGATGG ACAAGGAGGT CTGTGCCAAA GAAGAATCAA TAAGCACATA TGAGCACTTC TGTATATCAG TATTGAGCAC TGTAGGCA ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTT GTGAGGACTC CGTGCCCACC ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG ACCTTTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TCTTTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTGGC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AATTTGTGTA AGGATTGAGG GACAGTTGCT T ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTC GTGAGGACTC CGTGCCCACC ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG ACCTTTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TCTTTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTGGC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC EPI-109 231

CTCCTTCATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AATTTGTGTA AGGATTGAGG GACAGTTGCT T GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGGGAC ATCAGGCTGC CCCGCAGTAC CAGGGAGCGA CTGAAGTGCC CATGCCGCTT GCTCCGGAGA AGGTGGGTGC CGGGCAGGGG CTGCTCCAGC CGCCTCACCT CTGCTGGGAG GACAAACTGT CCCAGCACAG AGGGAGGGAG GGAGGGCAGG CAGCGGGGAG AAGTTTCCCT GTGGTCGTGG GGAGTT GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGCCC ATGCCGCTTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTTTCCCTG TGGTCGTGGG GAGTT GAGCTCTTCA ATATTTTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA CACACCTTTT CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA CTGGCAAGTC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGTTTCC CTGTCTCCAT GATGATGGGA TCAGGCTTGA TTGCTGGTTT GTAGGCTTGT TATGAATCAA GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTTCC CCAGATCCAC TGGGCCCACT CTTATCTGTT CTCTTCTGAA GGAAGGGTTT TAAGGCTTCA AAAAAAAATG TTTTGAAAGT CCCTGCCCTT TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAAAC TGAGAAAGCC AGCCTGAGCC TTGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGCC ACTGTCGCCC TTGGGAGCCG TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTTTA CACCTTCCGC GTAAACGCCC ACTGTTTACA TCCAAAACTC AGACACAAAA TAACCACCTC AAGAAGATAA ATAATGATAA GAAATAAATG TTACGCGAGG CAAATTTATT CACATGGGGC TTCCCAGGCC ACTTTGTGGT CAGCCGGGAG GGACGTTTTT GCCGTCCCAC GACTCCAACG GGCAGCCGGG CCTACGCAAA CATGGAAATC TTCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCTT CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCTTCAAAG ATGAGCTGTT CCCGCCGCCA CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGAGAAG GTGGGTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AGTTGGGAAA AGTTCCCTTC CTTCCGGAGG GAGG CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT GCCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAGCTTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT CTTTAATCTA TTCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA TTGAGCACTT GCTGTATATG CAGTATTGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCTTGAAGG AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTT TTATGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC GGTGTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTT CCACCTGTCA TTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCATTTGGAG AGAAGGCCAT GTCTTCAAAG TCTGATTTGT GATGAGGCAG AGGAAGATAT TTCTAATCGG TCTTGCCCAG AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG GCCTGCTCAG GGACTGTTCC TGTCTCAGCA ACCAAGGGAT TGTTCCTGTC AATCAATGGT TTATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGTGT TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT AAATGAATAT TTATTAGCTG GTTGGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA ACCTAGAAGG GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGTTA GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATTTACAT GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAAT TTTAAAGCAA AAGCGTGAAA AAAAAGATTC CCTCCTTACC CCCAACCCAC TCTTTTTTCC CACCACCCAC TCTCCTCTGC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATTTAGTATT AGTATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC TGTGTTTTGT CACACAGGGC AGTCATTCAG CACCAGAGCA CGTGATGGTC TGAGACTCTC TTAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC TGTCCTGTGA AAGACTCAAT GAGCTGTTAT GTTGTAAACA GGAAGCATTT CACATCCAAA CGAGAAAATC ATGTAAACAT GTGTCTTTTC TGTAGAGCAT AATAAATGGA TGAGGTTTTT GCAAAAAAAA AAAAAAAAA AAATGATAGA CCGTCAATAA TTTGTTAAAT GCTTTTTAAA ATGAATGCTT TAAGCCGGGT GCAGTGCCTC ACATCTGTAA TCCCAGCACT TTGGAGCCGA GCGGGTGGAT TGTGTGAGGT CAGGAGTTCG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCTCTACC AAAAATACAA AAATTAGCCA GGCATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG GAGAATCGCT TGAACCCGGG AGGCAAGGTT GCAGTGAGCC AAGATTACGC CATTGTACTC CAGCCTGGGT GACAGAGAGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATTAC GCTTCAAACA CATGATCTCT CACCACTGTT GAATTTTCTT TCTATGAGCC CAGGAGGGCC TCTCAGAGAG GAAAGCTCCT AGGTCTTCCT TTCCCTCTGC AAACTCCCTG CCTTGAAGGT TCAGAAGGAC TGTGCGTGCT CGTTGCATCC TTTGCAAGTG TCCAAACCCT GATCCCAGCT GTGCTTAGGG GTTCCTGCAA ACCTTTTCCA GGTGTTAATT ACCTCCCACT TCATTTCCTG TTTACCAACT CAGCTTTTTG EPI-109 232

TTTTAGTGTG TTTGAATTCC CTGAACTGAC CGTTGTCTGA TCTCCACCTC CCAACTGAAT TAGGGGAGCT GGGCTTCTGG AAACCCAGGT GCCGGGTGTT GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACACACAC ACCCACATAC CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TTGGACATGC ATAGACCACA GCTTTCCACA CCCTTCCTAG ACAGGGGTCA CTTGGTATCC TGGAGAGAGT GTGAAGTCCT GGAATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA CAAGTCACCA CCAACCCATC TGCGCCTTGT TTACCTCCTC TGTGAGGCAA GCACAGAGCC CATGCCTGCC CCCCTGGATG GGAGTGATGT GAAACTTGAA GGGCGGTCAG AGCAAGGGTC GGGAATGGAA GGCCCTTGGG AAAAAAGGCC CTTTCAACTA GGGGCACAGA GGAGGCCCTG GGCTGAGAAC TTGACAGCAC CTTGTAATTG GTAAGCCAAG CCCGAAGGGA CTGGAAATAC TCAGATGTGT CTGTCTCCCT TATTAGGTTC AAAGTCCCTC AAGACCCTGT CTCCATCACA GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGACCCAA CCAGCCCTAT GGGGTCGCAT CCCCACCTGC CTGGAATTCT CCAAAGAACC TCCCCTTTAA CAGTTCCAGC CTTTAACAGT TCCAGTCTAA ACACATGACC TTTCTCCTCT AAATCAGCCC CCCATCTCTG CCTTTGCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC CCATCCATGT CCAATCAAGC ACTAGGCATG TCAGGTTTAC CCTCTAAACT CCTCTGGAAT CCAGTCTCTC AGTCTCCATC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCTTGCTTC CACTCTACCC CCACTGCAGT CCTGACTTCC TGAGCAGCAG CCAGGGCCTA ATCGATATTC ACACCAAGCG CCAACCTGAC TGAGATATCC TCCTGCACCA TCATCCCTCC ACCCTGTTTA GTTCTGCTCA CCCTCAGTGT TCTCATCAAT AATCCACTCC CCTCACAGGC GCGTTTGGGA CCCCATGTTC TATGCTCTCA CAGGACCTTT TGCTTGATTT TTCACTGTAC TTAGGTCAGT TTGCAGTTAT TAAGTGACTG AGCAATGTCT GGCTTCTCCA GTAGACTGTC AGCTCCTAGC CATTGTATAC CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG AGTCAGGGAC TCAGCAGTCT CCATTTCTCC GCCCTGCTGG AGAATGCGTG TATTTGGCAA TCCCCAGCCC CTGTGCCATC TAACCATCTT TTCTTCTCTG TTCAGCCCAG GTGTGGCCTC ACTCACATCC CACTCTCAGT CCAAATGTTC TCTCCCTGGA AGATATCAAT GTTTCTGTCT GTTCGTGAGG ACTCCGTGCC CACCACGGCC TCTTTCAGGT GAGTCAAAGG GATTCCTCAG TTCACTAGTT AGGGGAGGTG GGCAGACACC CTGGAGAACT CCCTGGAAAG CTCAACTCTC ATGCCCCGGA CAACAGTTGA AGGAACCATG GTGATGTTAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGTTG GAATCTTGGG AGCAGAGGGA ATGTTCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA AGGGCACATT CCTGGTTGTT ATATGTTTCT ATCTATCCCA GATGAACTTG GAAGTGAAGG GAAGAGAGTT AAACATTAAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC CTTGGAAACA AAATATCTCC AACACATGGC TGACATTTGG TGGGAGATCA GAACACCCTA AAGAGAGAAT TTAAGGGGAG GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC AGAGGATAGG GAGATCTGTT CTTGGGGACA GCATTTGCAA GAAACAAGGC TGAGGGGTCC ACTCCAACCT CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGGCCAT CTCAGCTGGG GCCACAGTGC ACTGGACCTA TAGTTTCCAA TTCCGCACTC AGCAGGCATC TTTCTGATGA TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCTTGGCT ACTGTCTTGC TGAGAAATTT ATAAGCAGCA TCTGGTGCTA TACTTTGGTC TCTAGTGAGT TAGCTCATGA AAGATGATAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GGTTTTCTGT AGCTACAGAA ATGGGGTTGA GGGTTGGACC AAGGGACTAC CCAGGGGAAG TCTTACCTTC AGAGGACTCT GGAAAGGAGG CTGCAAGTTT TCATGGGTCA AGAATTCAGA GCCCAGTAGA GACAGCTTAT CTCTGTTCCA AGATGTCTGG GGCCTTGGTT GGAAGATTCA AAGGCTAGGA AACCAGGAGC CACCAAAAGC GTAACTGGGG CCAGAGGATC CACTTTCAAG GTGGCAAGTT GGTTCCCCCC ATGTGGCTGC TTGAGTATCC TCACATGGCG GCTCACATCC TTCCAAGTAA GCAATGCAAA AGGCCAAGAA AGATGCTGCA AAGATGTTAT GACCTAGCCT CAGAAATCAC ACACCATCCC TGCCACCATT AGTAAGAAGT CCAGCCCACG TCCAGGAGAA GAGGAAGCAG ATTCCTCCTT TTGAAATGAA GAATATCAAG TAATTCGGGG GGCATATGAA AGCCACCACA CACCACAGGG ATCTTTTTAG AGCATACTTC TTATACCATC ACTGTAGTTC CTTAAGACTC AGGGGCAAAG CCTCACTTCC TTAGCACCCA GTGAAGACCA CGCTTACTCC CTCACTCAAC CTCTTGCTAC TTCCCACCTC TCCTGTCCAA CATCTAGTGT CACTTTCCAG AACATACCAA CAGCTTCCCC AGTTCTGTGC CTCTGCTCAG GCTGTTCCCC CTGCCTGGTC CACTTGTCCT CCTTCTTGTC CGGTCAAAAT GCTTCTTATC CTTCAAGACC CAGCTCTAGA GTCACCTCCA ACCCCTTACC CACCAGCCCC CTCTCCAAGT CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC CACCCTCTGG GCCACAGTTG TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG GTGTCTTCTT TGTGTTCTTG CACTCAGGGC AGAGCTCAGC ACAGAGCAGA CGCTCAAAAA ACATTTAAAG GATAGAAGCA TTGATTTGTG GGTCCCCCAG TCTGGCTCCA GGATGCCAGC CAGCTGCTCC TAGAAGCAAA CGGACTTTTC CTGGGAAATC CCAGAGGTGA TGATCAGTAA TCTCTCCCGT GACTCGTAGT TCAGCTCTTC CTCCATGAGC CTGACTATCA GTGGACCTTC CAGAAAGAGC CCCTTTTCCT TCTCTCACCC ACAGCACAGG GCACTGGGAA AATGCCCAAT GAGTCCTGCC TCTGGGTTGT GCTTTGGACT TTTCAGTGTG TCTCGCATCC ACTCTTCAAC TTGAATGTTG CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATTCAGGATG AGAGCAATAC CCTACTCCAA AGAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAATTTGC CCAAGACCAC ACAGCTAGGA GTGGAACTCA TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GGTAGAGATG AATTACAGCA ACAAGTCTAG AAAGGTGCCT GCCCTATGGT CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA GCCAGTGGGT TAAAGATGAG GTCACCAACA ACGGTGGTGT TGGAGTTTAC CACTGATAAT AAGGGTGCAA AATGTAAATT ACTAATGTTT ATTGAGCCTA GTGCAGTGCG TGGGGCATTT TGCACATTGT CTCTGATCCC TATGACAACC CTGAGAGGTA GTGGTTTTAA CTGCCATGTT ACAGGTGAGG TCATTGTGGT TCAAGGACGT TAAGTAACTT CCCCAGCGTG ACACGGCTTA TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT GGCTGCAAAG TCCCCACCCC CCTCGCCATC TGTATCCTCC AATCACTTCA GTGCTTTGCT GCATAGAAGG TAACGGAAAT CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCTC CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATT TTTCTCTTTT AATAAATTAA CTCACCCACC ACACGGCTTT GAGAGGCTCA AAGTTGACCA ACTCCCTTGG GAGGGCCCCG GTTGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC TTCAAGGAGG TCAAGGGTCC AACACTTGAG ATTGTTAGTG CTGTTGGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC CTCGAGATGA AGAACATGAG GCCCCCGTTT AGAACCAAGG ATCAGAGGGG GCTCTGTAAG ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT CGGCTTCTCC TTGTCCTGGC TGGTTGTCCT TAACCCCTGT CTCCTTCTGG ACCAGTTTTT GTCCTTCCCT TGTGACCGCT GAGGGGTAAC AGCCTCTTTC CACTTTCTTT CAGCGCCGAC ATGCTCAATG TCACCTTGCA AGGGCCCACT CTTAACGGGA CCTTTGCCCA GAGCAAATGC CCCCAAGTGG AGTGGCTGGG CTGGCTCAAC ACCATCCAGC CCCCCTTCCT CTGGGTGCTG TTCGTGCTGG CCACCCTAGA GAACATCTTT GTCCTCAGCG TCTTCTGCCT GCACAAGAGC AGCTGCACGG TGGCAGAGAT CTACCTGGGG AACCTGGCCG CAGCAGACCT GATCCTGGCC TGCGGGCTGC CCTTCTGGGC CATCACCATC TCCAACAACT TCGACTGGCT CTTTGGGGAG ACGCTCTGCC GCGTGGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG CATCTGTTTC CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG ATGCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTGGGGGTG TACGCTGCTC CTGAGCTCAC CCATGCTGGT GTTCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC GTCACCGCTT GTGTCATCAG CTACCCATCC CTCATCTGGG AAGTGTTCAC CAACATGCTC CTGAATGTCG TGGGCTTCCT GCTGCCCCTG AGTGTCATCA CCTTCTGCAC GATGCAGATC ATGCAGGTGC TGCGGAACAA CGAGATGCAG AAGTTCAAGG AGATCCAGAC GGAGAGGAGG GCCACGGTGC TAGTCCTGGT EPI-109 233

TGTGCTGCTG CTATTCATCA TCTGCTGGCT GCCCTTCCAG ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGGCATCC TCTCCAGCTG CCAGGACGAG CGCATCATCG ATGTAATCAC ACAGATCGCC TCCTTCATGG CCTACAGCAA CAGCTGCCTC AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTTCCGAA AGAAGTCTTG GGAGGTGTAC CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA TTCAGATGGA GAACTCCATG GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTGCA GGACTGGGCA GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA ATTTGTGTAA GGATTGAGGG ACAGTTGCTT TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG AAATGAGTTG ATGTCTCCGG TAAAACACCG GAGACTAATT CCTGCCCTGC CCAATTTTGC AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA ACAGCATTAC TGTTCTTATT TGCTGCCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGTG GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA CTGAGCTTCC CTCCCGTGTG TTCTCCGTCC CTGCCCCAGC AAGACAACTT AGATCTCCAG GAGAACTGCC ATCCAGCTTT GGTGCAATGG CTGAGTGCAC AAGTGAGTTG TTGCCCTGGG TTTCTTTAAT CTATTCAGCT AGAACTTTGA AGGACAATTT CTTGCATTAA TAAAGGTTAA GCCCTGAGGG GTCCCTGATA ACAACCTGGA GACCAGGATT TTATGGCTCC CCTCACTGAT GGACAAGGAG GTCTGTGCCA AAGAAGAATC CAATAAGCAC ATATTGAGCA CTTGCTGTAT ATGCAGTATT GAGCACTGTA GGCAAGAGGG AAGAAAGAGA AGGAGCCATC TCCATCTTGA AGGAACTCAA AGACTCAAGT GGGAACGACT GGGCACTGCC ACCACCAGAA AGCTGTTCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA TATGGACAGC AGAAGGGGGA GCCAGGTTCC AGCTCACCAA TACTATTGCA CACCACCTGT CCTGCCTC TGATCCTATC ACAACCTGAG AGTAGTTTTT ACTCCATTTA CAGGTGAGGT CATTGTGGTT CAAGGACGTT AAGTAACTTC CCCAGCTCAC ACGGCTTATA AGTAAGGCAG CCAGGATGTG AACCCAGTAG GACTATCTGG CTGCAAAGTC CCCACCCTCC CTCGCCATCT GTATCCTCCA ATCATCTTCA GTGCTTTGCT GATAGAAGGT ACGGAAATAC GATGCCACAG ACTGTCCAGG AAGACAGAAA CTAGGCAGAT GGGCTGGCCA TGGTCTCCAA GCCAGACTGG AATCTCCAGG TCTGGAATGA TATCATTTTT CTCTTTTAAT AAATTAACTC ACCCACCACA CGGCTTTGAG AGGCTCAAAG GTGACCAACT CCCTTGGGAG GGCCCCGGTT GATAAGGAAG GAATGTGAAT CCTCCCATCA CGGAAGCTTC AAGGAGGTCA AGGGTCCAAC ACTTGAGATT GTTAGTGCTG TTGGTGGATA CTGCAGAATA TCCAGTGGAG CCTCAGATGA AGAACATGAG GCCCCGTTTA GATCCAAGGA TCAGAGGGGG CTCTGTAAGA CCCAGGGGAG TCAGGTGCAC TGGAGCGCGG GCTGCAGAAA ACAGCCTGAG CTCCACCTCG GCTTCTCCTT GCCCTGGCTG GTTGTCCTTA ACCCCTGTCT CCTTCTGGAC CAGTTTTTGT CCTTCCCTTG TGACCTGAGG GGTAACAGCC TCTTTTCCAC TTTCTTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTT AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCCCC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTTTGTC CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC AACAACTTCG ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA TTCATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC TTCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTGTTGA TGTCTCCGGT AAAACACCGG AGACTAATTC CTGCCCTGCC CAATTTTCGA GGGAGCATGG CTGTGAGGAT GGGGTGAACT CACGCACAGC CAAGGACTCC AAAATCACAA CAGCATTACT GTTCTTATTT GCTGCCACAC CTGAGCCAGC CTGCTCCTTC CCAGGAGTGG AGGAGGCCTG GGGGAGGGAG AGGAGTGACT GAGCTTCCCT CCCGTGTGTT CTCCGTCCCT GCCCCAGCAA GACAACTTAG ATCTCCAGGA GAACTGCCAT CCACGTTTGG TGCAATGGCT GAGTGCACAA GTGAGTTGTT GCCCTGGGTT TCTTTAATCT ATCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTTGATAAC AACCTGGAGA CCAGGATTTT ATGGCTCCCC TCACTGATGG ACAAGGAGGT CTGTGCCAAA GAAGAATCAA TAAGCACATA TGAGCACTTC TGTATATCAG TATTGAGCAC TGTAGGCA ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTT GTGAGGACTC CGTGCCCACC ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG ACCTTTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TCTTTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTGGC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AATTTGTGTA AGGATTGAGG GACAGTTGCT T ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTC GTGAGGACTC CGTGCCCACC ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG ACCTTTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TCTTTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA EPI-109 234

CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTGGC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AATTTGTGTA AGGATTGAGG GACAGTTGCT T GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGGGAC ATCAGGCTGC CCCGCAGTAC CAGGGAGCGA CTGAAGTGCC CATGCCGCTT GCTCCGGAGA AGGTGGGTGC CGGGCAGGGG CTGCTCCAGC CGCCTCACCT CTGCTGGGAG GACAAACTGT CCCAGCACAG AGGGAGGGAG GGAGGGCAGG CAGCGGGGAG AAGTTTCCCT GTGGTCGTGG GGAGTT GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGCCC ATGCCGCTTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTTTCCCTG TGGTCGTGGG GAGTT GAGCTCTTCA ATATTTTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA CACACCTTTT CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA CTGGCAAGTC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGTTTCC CTGTCTCCAT GATGATGGGA TCAGGCTTGA TTGCTGGTTT GTAGGCTTGT TATGAATCAA GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTTCC CCAGATCCAC TGGGCCCACT CTTATCTGTT CTCTTCTGAA GGAAGGGTTT TAAGGCTTCA AAAAAAAATG TTTTGAAAGT CCCTGCCCTT TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAAAC TGAGAAAGCC AGCCTGAGCC TTGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGCC ACTGTCGCCC TTGGGAGCCG TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTTTA CACCTTCCGC GTAAACGCCC ACTGTTTACA TCCAAAACTC AGACACAAAA TAACCACCTC AAGAAGATAA ATAATGATAA GAAATAAATG TTACGCGAGG CAAATTTATT CACATGGGGC TTCCCAGGCC ACTTTGTGGT CAGCCGGGAG GGACGTTTTT GCCGTCCCAC GACTCCAACG GGCAGCCGGG CCTACGCAAA CATGGAAATC TTCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCTT CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCTTCAAAG ATGAGCTGTT CCCGCCGCCA CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGAGAAG GTGGGTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AGTTGGGAAA AGTTCCCTTC CTTCCGGAGG GAGG -3' (FRAG. NO:2275) (SEQ. ID NO:2286)

5'- GAGCTCTTCA ATATTTTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA CACACCTTTT CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA CTGGCAAGTC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGTTTCC CTGTCTCCAT GATGATGGGA TCAGGCTTGA TTGCTGGTTT GTAGGCTTGT TATGAATCAA GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTTCC CCAGATCCAC TGGGCCCACT CTTATCTGTT CTCTTCTGAA GGAAGGGTTT TAAGGCTTCA AAAAAAAATG TTTTGAAAGT CCCTGCCCTT TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAAAC TGAGAAAGCC AGCCTGAGCC TTGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGCC ACTGTCGCCC TTGGGAGCCG TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTTTA CACCTTCCGC GTAAACGCCC ACTGTTTACA TCCAAAACTC AGACACAAAA TAACCACCTC AAGAAGATAA ATAATGATAA GAAATAAATG TTACGCGAGG CAAATTTATT CACATGGGGC TTCCCAGGCC ACTTTGTGGT CAGCCGGGAG GGACGTTTTT GCCGTCCCAC GACTCCAACG GGCAGCCGGG CCTACGCAAA CATGGAAATC TTCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCTT CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCTTCAAAG ATGAGCTGTT CCCGCCGCCA CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGAGAAG GTGGGTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AGTTGGGAAA AGTTCCCTTC CTTCCGGAGG GAGG -3' (FRAG. NO:2275) (SEQ. ID NO:2461)

5'- GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGCCC ATGCCGCTTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTTTCCCTG TGGTCGTGGG GAGTT -3' (FRAG. NO:2275) (SEQ. ID NO:2460) 5'- GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGGGAC ATCAGGCTGC CCCGCAGTAC CAGGGAGCGA CTGAAGTGCC CATGCCGCTT GCTCCGGAGA AGGTGGGTGC CGGGCAGGGG CTGCTCCAGC CGCCTCACCT CTGCTGGGAG GACAAACTGT CCCAGCACAG AGGGAGGGAG GGAGGGCAGG CAGCGGGGAG AAGTTTCCCT GTGGTCGTGG GGAGTT -3' (FRAG. NO:2275) (SEQ. ID NO:2459)

5'- ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTCTCTCTTC GTGAGGACTC CGTGCCCACC ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG ACCTTTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TCTTTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA EPI-109 235

GCTACCCATC CCTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTGGC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AATTTGTGTA AGGATTGAGG GACAGTTGCT T -3' (FRAG. NO:2275) (SEQ. ID NO:2458)

5'- ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTT GTGAGGACTC CGTGCCCACC ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG ACCTTTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TCTTTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTGGC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AATTTGTGTA AGGATTGAGG GACAGTTGCT T -3' (FRAG. NO:2275) (SEQ. ID NO:2457)

5'- TGATCCTATC ACAACCTGAG AGTAGTTTTT ACTCCATTTA CAGGTGAGGT CATTGTGGTT CAAGGACGTT AAGTAACTTC CCCAGCTCAC ACGGCTTATA AGTAAGGCAG CCAGGATGTG AACCCAGTAG GACTATCTGG CTGCAAAGTC CCCACCCTCC CTCGCCATCT GTATCCTCCA ATCATCTTCA GTGCTTTGCT GATAGAAGGT ACGGAAATAC GATGCCACAG ACTGTCCAGG AAGACAGAAA CTAGGCAGAT GGGCTGGCCA TGGTCTCCAA GCCAGACTGG AATCTCCAGG TCTGGAATGA TATCATTTTT CTCTTTTAAT AAATTAACTC ACCCACCACA CGGCTTTGAG AGGCTCAAAG GTGACCAACT CCCTTGGGAG GGCCCCGGTT GATAAGGAAG GAATGTGAAT CCTCCCATCA CGGAAGCTTC AAGGAGGTCA AGGGTCCAAC ACTTGAGATT GTTAGTGCTG TTGGTGGATA CTGCAGAATA TCCAGTGGAG CCTCAGATGA AGAACATGAG GCCCCGTTTA GATCCAAGGA TCAGAGGGGG CTCTGTAAGA CCCAGGGGAG TCAGGTGCAC TGGAGCGCGG GCTGCAGAAA ACAGCCTGAG CTCCACCTCG GCTTCTCCTT GCCCTGGCTG GTTGTCCTTA ACCCCTGTCT CCTTCTGGAC CAGTTTTTGT CCTTCCCTTG TGACCTGAGG GGTAACAGCC TCTTTTCCAC TTTCTTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTT AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCCCC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTTTGTC CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTCCCCT TCTGGGCCAT CACCATCTCC AACAACTTCG ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA TTCATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC TTCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTGTTGA TGTCTCCGGT AAAACACCGG AGACTAATTC CTGCCCTGCC CAATTTTCGA GGGAGCATGG CTGTGAGGAT GGGGTGAACT CACGCACAGC CAAGGACTCC AAAATCACAA CAGCATTACT GTTCTTATTT GCTGCCACAC CTGAGCCAGC CTGCTCCTTC CCAGGAGTGG AGGAGGCCTG GGGGAGGGAG AGGAGTGACT GAGCTTCCCT CCCGTGTGTT CTCCGTCCCT GCCCCAGCAA GACAACTTAG ATCTCCAGGA GAACTGCCAT CCACGTTTGG TGCAATGGCT GAGTGCACAA GTGAGTTGTT GCCCTGGGTT TCTTTAATCT ATCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTTGATAAC AACCTGGAGA CCAGGATTTT ATGGCTCCCC TCACTGATGG ACAAGGAGGT CTGTGCCAAA GAAGAATCAA TAAGCACATA TGAGCACTTC TGTATATCAG TATTGAGCAC TGTAGGCA -3' (FRAG. NO:2275) (SEQ. ID NO:2456)

5'- CTGCAGAAAA CAGCCTGAGC TCCACCTCGG CTTCTCCTTG CCCTGGCTGG TTGTCCTTAA CCCCTGTCTC CTTCTGGACC AGTTTTTGTC CTTCCCTTGT GACCCTGAGG GGTAACAGCC TCTTTTCCAC TTTCTTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTT AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCCCC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTTTGTC CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTCCCCT TCTGGGCCAT CACCATCTCC AACAACTTCG ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA TTCATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC TTCATGGCCT ACAGCAACAG EPI-109 236

CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT GNCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGCAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTCCCATC CAGCTTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT CTTTAATCTA TTCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA CAAGGGAGGT CTGTGCCAAA GAAGAATCCA ATAAGCACAT ATTGAGCACT TGCTGTATAT GCAGTATTGA GCACTGTAGG CAAGAGGGAA GAAAGAGAAG GAGCCATCTC CATCTTGAAG GAACTCAAAG ACTCAAGTGG GAACGACTGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTC TTCTGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG AGGTCTAGA -3' (FRAG. NO:2275) (SEQ. ID NO:2455)

5'- AAATGATAGA CCGTCAATAA TTTGTTAAAT GCTTTTTAAA ATGAATGCTT TAAGCCGGGT GCAGTGCCTC ACATCTGTAA TCCCAGCACT TTGGAGCCGA GCGGGTGGAT TGTGTGAGGT CAGGAGTTCG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCTCTACC AAAAATACAA AAATTAGCCA GGCATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG GAGAATCGCT TGAACCCGGG AGGCAAGGTT GCAGTGAGCC AAGATTACGC CATTGTACTC CAGCCTGGGT GACAGAGAGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATTAC GCTTCAAACA CATGATCTCT CACCACTGTT GAATTTTCTT TCTATGAGCC CAGGAGGGCC TCTCAGAGAG GAAAGCTCCT AGGTCTTCCT TTCCCTCTGC AAACTCCCTG CCTTGAAGGT TCAGAAGGAC TGTGCGTGCT CGTTGCATCC TTTGCAAGTG TCCAAACCCT GATCCCAGCT GTGCTTAGGG GTTCCTGCAA ACCTTTTCCA GGTGTTAATT ACCTCCCACT TCATTTCCTG TTTACCAACT CAGCTTTTTG TTTTAGTGTG TTTGAATTCC CTGAACTGAC CGTTGTCTGA TCTCCACCTC CCAACTGAAT TAGGGGAGCT GGGCTTCTGG AAACCCAGGT GCCGGGTGTT GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACACACAC ACCCACATAC CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TTGGACATGC ATAGACCACA GCTTTCCACA CCCTTCCTAG ACAGGGGTCA CTTGGTATCC TGGAGAGAGT GTGAAGTCCT GGAATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA CAAGTCACCA CCAACCCATC TGCGCCTTGT TTACCTCCTC TGTGAGGCAA GCACAGAGCC CATGCCTGCC CCCCTGGATG GGAGTGATGT GAAACTTGAA GGGCGGTCAG AGCAAGGGTC GGGAATGGAA GGCCCTTGGG AAAAAAGGCC CTTTCAACTA GGGGCACAGA GGAGGCCCTG GGCTGAGAAC TTGACAGCAC CTTGTAATTG GTAAGCCAAG CCCGAAGGGA CTGGAAATAC TCAGATGTGT CTGTCTCCCT TATTAGGTTC AAAGTCCCTC AAGACCCTGT CTCCATCACA GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGACCCAA CCAGCCCTAT GGGGTCGCAT CCCCACCTGC CTGGAATTCT CCAAAGAACC TCCCCTTTAA CAGTTCCAGC CTTTAACAGT TCCAGTCTAA ACACATGACC TTTCTCCTCT AAATCAGCCC CCCATCTCTG CCTTTGCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC CCATCCATGT CCAATCAAGC ACTAGGCATG TCAGGTTTAC CCTCTAAACT CCTCTGGAAT CCAGTCTCTC AGTCTCCATC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCTTGCTTC CACTCTACCC CCACTGCAGT CCTGACTTCC TGAGCAGCAG CCAGGGCCTA ATCGATATTC ACACCAAGCG CCAACCTGAC TGAGATATCC TCCTGCACCA TCATCCCTCC ACCCTGTTTA GTTCTGCTCA CCCTCAGTGT TCTCATCAAT AATCCACTCC CCTCACAGGC GCGTTTGGGA CCCCATGTTC TATGCTCTCA CAGGACCTTT TGCTTGATTT TTCACTGTAC TTAGGTCAGT TTGCAGTTAT TAAGTGACTG AGCAATGTCT GGCTTCTCCA GTAGACTGTC AGCTCCTAGC CATTGTATAC CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG AGTCAGGGAC TCAGCAGTCT CCATTTCTCC GCCCTGCTGG AGAATGCGTG TATTTGGCAA TCCCCAGCCC CTGTGCCATC TAACCATCTT TTCTTCTCTG TTCAGCCCAG GTGTGGCCTC ACTCACATCC CACTCTGAGT CCAAATGTTC TCTCCCTGGA AGATATCAAT GTTTCTGTCT GTTCGTGAGG ACTCCGTGCC CACCACGGCC TCTTTCAGGT GAGTCAAAGG GATTCCTCAG TTCACTAGTT AGGGGAGGTG GGCAGACACC CTGGAGAACT CCCTGGAAAG CTCAACTCTC ATGCCCCGGA CAACAGTTGA AGGAACCATG GTGATGTTAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGTTG GAATCTTGGG AGCAGAGGGA ATGTTCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA AGGGCACATT CCTGGTTGTT ATATGTTTCT ATCTATCCCA GATGAACTTG GAAGTGAAGG GAAGAGAGTT AAACATTAAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC CTTGGAAACA AAATATCTCC AACACATGGC TGACATTTGG TGGGAGATCA GAACACCCTA AAGAGAGAAT TTAAGGGGAG GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC AGAGGATAGG GAGATCTGTT CTTGGGGACA GCATTTGCAA GAAACAAGGC TGAGGGGTCC ACTCCAACCT CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGGCCAT CTCAGCTGGG GCCACAGTGC ACTGGACCTA TAGTTTCCAA TTCCGCACTC AGCAGGCATC TTTCTGATGA TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCTTGGCT ACTGTCTTGC TGAGAAATTT ATAAGCAGCA TCTGGTGCTA TACTTTGGTC TCTAGTGAGT TAGCTCATGA AAGATGATAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GGTTTTCTGT AGCTACAGAA ATGGGGTTGA GGGTTGGACC AAGGGACTAC CCAGGGGAAG TCTTACCTTC AGAGGACTCT GGAAAGGAGG CTGCAAGTTT TCATGGGTCA AGAATTCAGA GCCCAGTAGA GACAGCTTAT CTCTGTTCCA AGATGTCTGG GGCCTTGGTT GGAAGATTCA AAGGCTAGGA AACCAGGAGC CACCAAAAGC GTAACTGGGG CCAGAGGATC CACTTTCAAG GTGGCAAGTT GGTTCCCCCC ATGTGGCTGC TTGAGTATCC TCACATGGCG GCTCACATCC TTCCAAGTAA GCAATGCAAA AGGCCAAGAA AGATGCTGCA AAGATGTTAT GACCTAGCCT CAGAAATCAC ACACCATCCC TGCCACCATT AGTAAGAAGT CCAGCCCACG TCCAGGAGAA GAGGAAGCAG ATTCCTCCTT TTGAAATGAA GAATATCAAG TAATTCGGGG GGCATATGAA AGCCACCACA CACCACAGGG ATCTTTTTAG AGCATACTTC TTATACCATC ACTGTAGTTC CTTAAGACTC AGGGGCAAAG CCTCACTTCC TTAGCACCCA GTGAAGACCA CGCTTACTCC CTCACTCAAC CTCTTGCTAC TTCCCACCTC TCCTGTCCAA CATCTAGTGT CACTTTCCAG AACATACCAA CAGCTTCCCC AGTTCTGTGC CTCTGCTCAG GCTGTTCCCC CTGCCTGGTC CACTTGTCCT CCTTCTTGTC CGGTCAAAAT GCTTCTTATC CTTCAAGACC CAGCTCTAGA GTCACCTCCA ACCCCTTACC CACCAGCCCC CTCTCCAAGT CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC CACCCTCTGG GCCACAGTTG TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG GTGTCTTCTT TGTGTTCTTG CACTCAGGGC AGAGCTCAGC ACAGAGCAGA CGCTCAAAAA ACATTTAAAG GATAGAAGCA TTGATTTGTG GGTCCCCCAG TCTGGCTCCA GGATGCCAGC CAGCTGCTCC TAGAAGCAAA CGGACTTTTC CTGGGAAATC CCAGAGGTGA TGATCAGTAA TCTCTCCCGT GACTCGTAGT TCAGCTCTTC CTCCATGAGC CTGACTATCA GTGGACCTTC CAGAAAGAGC CCCTTTTCCT TCTCTCACCC ACAGCACAGG GCACTGGGAA AATGCCCAAT GAGTCCTGCC TCTGGGTTGT GCTTTGGACT TTTCAGTGTG EPI-109 237

TCTCGCATCC ACTCTTCAAC TTGAATGTTG CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATTCAGGATG AGAGCAATAC CCTACTCCAA AGAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAATTTGC CCAAGACCAC ACAGCTAGGA GTGGAACTCA TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GGTAGAGATG AATTACAGCA ACAAGTCTAG AAAGGTGCCT GCCCTATGGT CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA GCCAGTGGGT TAAAGATGAG GTCACCAACA ACGGTGGTGT TGGAGTTTAC CACTGATAAT AAGGGTGCAA AATGTAAATT ACTAATGTTT ATTGAGCCTA GTGCAGTGCG TGGGGCATTT TGCACATTGT CTCTGATCCC TATGACAACC CTGAGAGGTA GTGGTTTTAA CTGCCATGTT ACAGGTGAGG TCATTGTGGT TCAAGGACGT TAAGTAACTT CCCCAGCGTG ACACGGCTTA TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT GGCTGCAAAG TCCCCACCCC CCTCGCCATC TGTATCCTCC AATCACTTCA GTGCTTTGCT GCATAGAAGG TAACGGAAAT CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCTC CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATT TTTCTCTTTT AATAAATTAA CTCACCCACC ACACGGCTTT GAGAGGCTCA AAGTTGACCA ACTCCCTTGG GAGGGCCCCG GTTGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC TTCAAGGAGG TCAAGGGTCC AACACTTGAG ATTGTTAGTG CTGTTGGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC CTCGAGATGA AGAACATGAG GCCCCCGTTT AGAACCAAGG ATCAGAGGGG GCTCTGTAAG ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT CGGCTTCTCC TTGTCCTGGC TGGTTGTCCT TAACCCCTGT CTCCTTCTGG ACCAGTTTTT GTCCTTCCCT TGTGACCGCT GAGGGGTAAC AGCCTCTTTC CACTTTCTTT CAGCGCCGAC ATGCTCAATG TCACCTTGCA AGGGCCCACT CTTAACGGGA CCTTTGCCCA GAGCAAATGC CCCCAAGTGG AGTGGCTGGG CTGGCTCAAC ACCATCCAGC CCCCCTTCCT CTGGGTGCTG TTCGTGCTGG CCACCCTAGA GAACATCTTT GTCCTCAGCG TCTTCTGCCT GCACAAGAGC AGCTGCACGG TGGCAGAGAT CTACCTGGGG AACCTGGCCG CAGCAGACCT GATCCTGGCC TGCGGGCTGC CCTTCTGGGC CATCACCATC TCCAACAACT TCGACTGGCT CTTTGGGGAG ACGCTCTGCC GCGTGGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG CATCTGTTTC CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG ATGCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTGGGGGTG TACGCTGCTC CTGAGCTCAC CCATGCTGGT GTTCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC GTCACCGCTT GTGTCATCAG CTACCCATCC CTCATCTGGG AAGTGTTCAC CAACATGCTC CTGAATGTCG TGGGCTTCCT GCTGCCCCTG AGTGTCATCA CCTTCTGCAC GATGCAGATC ATGCAGGTGC TGCGGAACAA CGAGATGCAG AAGTTCAAGG AGATCCAGAC GGAGAGGAGG GCCACGGTGC TAGTCCTGGT TGTGCTGCTG CTATTCATCA TCTGCTGGCT GCCCTTCCAG ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGGCATCC TCTCCAGCTG CCAGGACGAG CGCATCATCG ATGTAATCAC ACAGATCGCC TCCTTCATGG CCTACAGCAA CAGCTGCCTC AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTTCCGAA AGAAGTCTTG GGAGGTGTAC CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA TTCAGATGGA GAACTCCATG GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTGCA GGACTGGGCA GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA ATTTGTGTAA GGATTGAGGG ACAGTTGCTT TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG AAATGAGTTG ATGTCTCCGG TAAAACACCG GAGACTAATT CCTGCCCTGC CCAATTTTGC AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA ACAGCATTAC TGTTCTTATT TGCTGCCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGTG GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA CTGAGCTTCC CTCCCGTGTG TTCTCCGTCC CTGCCCCAGC AAGACAACTT AGATCTCCAG GAGAACTGCC ATCCAGCTTT GGTGCAATGG CTGAGTGCAC AAGTGAGTTG TTGCCCTGGG TTTCTTTAAT CTATTCAGCT AGAACTTTGA AGGACAATTT CTTGCATTAA TAAAGGTTAA GCCCTGAGGG GTCCCTGATA ACAACCTGGA GACCAGGATT TTATGGCTCC CCTCACTGAT GGACAAGGAG GTCTGTGCCA AAGAAGAATC CAATAAGCAC ATATTGAGCA CTTGCTGTAT ATGCAGTATT GAGCACTGTA GGCAAGAGGG AAGAAAGAGA AGGAGCCATC TCCATCTTGA AGGAACTCAA AGACTCAAGT GGGAACGACT GGGCACTGCC ACCACCAGAA AGCTGTTCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA TATGGACAGC AGAAGGGGGA GCCAGGTTCC AGCTCACCAA TACTATTGCA CACCACCTGT CCTGCCTC -3' (FRAG. NO:2275) (SEQ. ID NO:2454)

5'- CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT GCCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTCCCATC CAGCTTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT CTTTAATCTA TTCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA TTGAGCACTT GCTGTATATG CAGTATTGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCTTGAAGG AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTT TTATGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC GGTGTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTT CCACCTGTCA TTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCATTTGGAG AGAAGGCCAT GTCTTCAAAG TCTGATTTGT GATGAGGCAG AGGAAGATAT TTCTAATCGG TCTTGCCCAG AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG GCCTGCTCAG GGACTGTTCC TGTCTCAGCA ACCAAGGGAT TGTTCCTGTC AATCAATGGT TTATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGTGT TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT AAATGAATAT TTATTAGCTG GTTGGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA ACCTAGAAGG GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGTTA GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATTTACAT GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAAT TTTAAAGCAA AAGCGTGAAA AAAAAGATTC CCTCCTTACC CCCAACCCAC TCTTTTTTCC CACCACCCAC TCTCCTCTGC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATTTAGTATT AGTATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC TGTGTTTTGT CACACAGGGC AGTCATTCAG EPI-109 238

CACCAGAGCA CGTGATGGTC TGAGACTCTC TTAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC TGTCCTGTGA AAGACTCAAT GAGCTGTTAT GTTGTAAACA GGAAGCATTT CACATCCAAA CGAGAAAATC ATGTAAACAT GTGTCTTTTC TGTAGAGCAT AATAAATGGA TGAGGTTTTT GCAAAAAAAA AAAAAAAAA -3' (FRAG. NO:2275) (SEQ. ID NO:2453) 5'- GAGCTCTTCA ATATTTTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA CACACCTTTT CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA CTGGCAAGTC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGTTTCC CTGTCTCCAT GATGATGGGA TCAGGCTTGA TTGCTGGTTT GTAGGCTTGT TATGAATCAA GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTTCC CCAGATCCAC TGGGCCCACT CTTATCTGTT CTCTTCTGAA GGAAGGGTTT TAAGGCTTCA AAAAAAAATG TTTTGAAAGT CCCTGCCCTT TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAAAC TGAGAAAGCC AGCCTGAGCC TTGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGCC ACTGTCGCCC TTGGGAGCCG TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTTTA CACCTTCCGC GTAAACGCCC ACTGTTTACA TCCAAAACTC AGACACAAAA TAACCACCTC AAGAAGATAA ATAATGATAA GAAATAAATG TTACGCGAGG CAAATTTATT CACATGGGGC TTCCCAGGCC ACTTTGTGGT CAGCCGGGAG GGACGTTTTT GCCGTCCCAC GACTCCAACG GGCAGCCGGG CCTACGCAAA CATGGAAATC TTCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCTT CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCTTCAAAG ATGAGCTGTT CCCGCCGCCA CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGAGAAG GTGGGTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AGTTGGGAAA AGTTCCCTTC CTTCCGGAGG GAGG -3' (FRAG. NO:2275) (SEQ. ID NO:2452)

5'- GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGCCC ATGCCGCTTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTTTCCCTG TGGTCGTGGG GAGTT -3' (FRAG. NO:2275) (SEQ. ID NO:2451) 5'- GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGGGAC ATCAGGCTGC CCCGCAGTAC CAGGGAGCGA CTGAAGTGCC CATGCCGCTT GCTCCGGAGA AGGTGGGTGC CGGGCAGGGG CTGCTCCAGC CGCCTCACCT CTGCTGGGAG GACAAACTGT CCCAGCACAG AGGGAGGGAG GGAGGGCAGG CAGCGGGGAG AAGTTTCCCT GTGGTCGTGG GGAGTT -3' (FRAG. NO:2275) (SEQ. ID NO:2450)

5'- ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTC GTGAGGACTC CGTGCCCACC ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG ACCTTTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TCTTTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTGGC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AATTTGTGTA AGGATTGAGG GACAGTTGCT T -3' (FRAG. NO:2275) (SEQ. ID NO:2449)

5'- ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTT GTGAGGACTC CGTGCCCACC ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG ACCTTTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TCTTTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTGGC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AATTTGTGTA AGGATTGAGG GACAGTTGCT T -3' (FRAG. NO:2275) (SEQ. ID NO:2448)

5'- TGATCCTATC ACAACCTGAG AGTAGTTTTT ACTCCATTTA CAGGTGAGGT CATTGTGGTT CAAGGACGTT AAGTAACTTC CCCAGCTCAC ACGGCTTATA AGTAAGGCAG CCAGGATGTG AACCCAGTAG GACTATCTGG CTGCAAAGTC CCCACCCTCC CTCGCCATCT GTATCCTCCA ATCATCTTCA GTGCTTTGCT GATAGAAGGT ACGGAAATAC GATGCCACAG ACTGTCCAGG AAGACAGAAA CTAGGCAGAT GGGCTGGCCA TGGTCTCCAA GCCAGACTGG AATCTCCAGG TCTGGAATGA TATCATTTTT CTCTTTTAAT AAATTAACTC ACCCACCACA CGGCTTTGAG AGGCTCAAAG GTGACCAACT CCCTTGGGAG GGCCCCGGTT GATAAGGAAG GAATGTGAAT CCTCCCATCA CGGAAGCTTC AAGGAGGTCA AGGGTCCAAC ACTTGAGATT GTTAGTGCTG EPI-109 239

TTGGTGGATA CTGCAGAATA TCCAGTGGAG CCTCAGATGA AGAACATGAG GCCCCGTTTA GATCCAAGGA TCAGAGGGGG CTCTGTAAGA CCCAGGGGAG TCAGGTGCAC TGGAGCGCGG GCTGCAGAAA ACAGCCTGAG CTCCACCTCG GCTTCTCCTT GCCCTGGCTG GTTGTCCTTA ACCCCTGTCT CCTTCTGGAC CAGTTTTTGT CCTTCCCTTG TGACCTGAGG GGTAACAGCC TCTTTTCCAC TTTCTTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTT AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCCCC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTTTGTC CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTCCCCT TCTGGGCCAT CACCATCTCC AACAACTTCG ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA TTCATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC TTCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTGTTGA TGTCTCCGGT AAAACACCGG AGACTAATTC CTGCCCTGCC CAATTTTCGA GGGAGCATGG CTGTGAGGAT GGGGTGAACT CACGCACAGC CAAGGACTCC AAAATCACAA CAGCATTACT GTTCTTATTT GCTGCCACAC CTGAGCCAGC CTGCTCCTTC CCAGGAGTGG AGGAGGCCTG GGGGAGGGAG AGGAGTGACT GAGCTTCCCT CCCGTGTGTT CTCCGTCCCT GCCCCAGCAA GACAACTTAG ATCTCCAGGA GAACTGCCAT CCACGTTTGG TGCAATGGCT GAGTGCACAA GTGAGTTGTT GCCCTGGGTT TCTTTAATCT ATCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTTGATAAC AACCTGGAGA CCAGGATTTT ATGGCTCCCC TCACTGATGG ACAAGGAGGT CTGTGCCAAA GAAGAATCAA TAAGCACATA TGAGCACTTC TGTATATCAG TATTGAGCAC TGTAGGCA -3'

(FRAG. NO:2275) (SEQ. ID NO:2447)

5'- CTGCAGAAAA CAGCCTGAGC TCCACCTCGG CTTCTCCTTG CCCTGGCTGG TTGTCCTTAA CCCCTGTCTC CTTCTGGACC AGTTTTTGTC CTTCCCTTGT GACCCTGAGG GGTAACAGCC TCTTTTCCAC TTTCTTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTT AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCCCC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTTTGTC CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTCCCCT TCTGGGCCAT CACCATCTCC AACAACTTCG ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA TTCATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC TTCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT GNCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGCAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTCCCATC CAGCTTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT CTTTAATCTA TTCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA CAAGGGAGGT CTGTGCCAAA GAAGAATCCA ATAAGCACAT ATTGAGCACT TGCTGTATAT GCAGTATTGA GCACTGTAGG CAAGAGGGAA GAAAGAGAAG GAGCCATCTC CATCTTGAAG GAACTCAAAG ACTCAAGTGG GAACGACTGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTC TTCTGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG AGGTCTAGA -3'

(FRAG. NO:2275) (SEQ. ID NO:2446) 5'- AAATGATAGA CCGTCAATAA TTTGTTAAAT GCTTTTTAAA ATGAATGCTT TAAGCCGGGT GCAGTGCCTC ACATCTGTAA TCCCAGCACT TTGGAGCCGA GCGGGTGGAT TGTGTGAGGT CAGGAGTTCG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCTCTACC AAAAATACAA AAATTAGCCA GGCATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG GAGAATCGCT TGAACCCGGG AGGCAAGGTT GCAGTGAGCC AAGATTACGC CATTGTACTC CAGCCTGGGT GACAGAGAGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATTAC GCTTCAAACA CATGATCTCT CACCACTGTT GAATTTTCTT TCTATGAGCC CAGGAGGGCC TCTCAGAGAG GAAAGCTCCT AGGTCTTCCT TTCCCTCTGC AAACTCCCTG CCTTGAAGGT TCAGAAGGAC TGTGCGTGCT CGTTGCATCC TTTGCAAGTG TCCAAACCCT GATCCCAGCT GTGCTTAGGG GTTCCTGCAA ACCTTTTCCA GGTGTTAATT ACCTCCCACT TCATTTCCTG TTTACCAACT CAGCTTTTTG TTTTAGTGTG TTTGAATTCC CTGAACTGAC CGTTGTCTGA TCTCCACCTC CCAACTGAAT TAGGGGAGCT GGGCTTCTGG AAACCCAGGT GCCGGGTGTT GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACACACAC ACCCACATAC CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TTGGACATGC ATAGACCACA GCTTTCCACA CCCTTCCTAG ACAGGGGTCA CTTGGTATCC TGGAGAGAGT GTGAAGTCCT GGAATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA CAAGTCACCA CCAACCCATC TGCGCCTTGT TTACCTCCTC TGTGAGGCAA GCACAGAGCC CATGCCTGCC CCCCTGGATG GGAGTGATGT GAAACTTGAA GGGCGGTCAG AGCAAGGGTC GGGAATGGAA GGCCCTTGGG AAAAAAGGCC CTTTCAACTA EPI-109 240

GGGGCACAGA GGAGGCCCTG GGCTGAGAAC TTGACAGCAC CTTGTAATTG GTAAGCCAAG CCCGAAGGGA CTGGAAATAC TCAGATGTGT CTGTCTCCCT TATTAGGTTC AAAGTCCCTC AAGACCCTGT CTCCATCACA GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGACCCAA CCAGCCCTAT GGGGTCGCAT CCCCACCTGC CTGGAATTCT CCAAAGAACC TCCCCTTTAA CAGTTCCAGC CTTTAACAGT TCCAGTCTAA ACACATGACC TTTCTCCTCT AAATCAGCCC CCCATCTCTG CCTTTGCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC CCATCCATGT CCAATCAAGC ACTAGGCATG TCAGGTTTAC CCTCTAAACT CCTCTGGAAT CCAGTCTCTC AGTCTCCATC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCTTGCTTC CACTCTACCC CCACTGCAGT CCTGACTTCC TGAGCAGCAG CCAGGGCCTA ATCGATATTC ACACCAAGCG CCAACCTGAC TGAGATATCC TCCTGCACCA TCATCCCTCC ACCCTGTTTA GTTCTGCTCA CCCTCAGTGT TCTCATCAAT AATCCACTCC CCTCACAGGC GCGTTTGGGA CCCCATGTTC TATGCTCTCA CAGGACCTTT TGCTTGATTT TTCACTGTAC TTAGGTCAGT TTGCAGTTAT TAAGTGACTG AGCAATGTCT GGCTTCTCCA GTAGACTGTC AGCTCCTAGC CATTGTATAC CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG AGTCAGGGAC TCAGCAGTCT CCATTTCTCC GCCCTGCTGG AGAATGCGTG TATTTGGCAA TCCCCAGCCC CTGTGCCATC TAACCATCTT TTCTTCTCTG TTCAGCCCAG GTGTGGCCTC ACTCACATCC CACTCTCAGT CCAAATGTTC TCTCCCTGGA AGATATCAAT GTTTCTGTCT GTTCGTGAGG ACTCCGTGCC CACCACGGCC TCTTTCAGGT GAGTCAAAGG GATTCCTCAG TTCACTAGTT AGGGGAGGTG GGCAGACACC CTGGAGAACT CCCTGGAAAG CTCAACTCTC ATGCCCCGGA CAACAGTTGA AGGAACCATG GTGATGTTAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGTTG GAATCTTGGG AGCAGAGGGA ATGTTCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA AGGGCACATT CCTGGTTGTT ATATGTTTCT ATCTATCCCA GATGAACTTG GAAGTGAAGG GAAGAGAGTT AAACATTAAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC CTTGGAAACA AAATATCTCC AACACATGGC TGACATTTGG TGGGAGATCA GAACACCCTA AAGAGAGAAT TTAAGGGGAG GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC AGAGGATAGG GAGATCTGTT CTTGGGGACA GCATTTGCAA GAAACAAGGC TGAGGGGTCC ACTCCAACCT CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGGCCAT CTCAGCTGGG GCCACAGTGC ACTGGACCTA TAGTTTCCAA TTCCGCACTC AGCAGGCATC TTTCTGATGA TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCTTGGCT ACTGTCTTGC TGAGAAATTT ATAAGCAGCA TCTGGTGCTA TACTTTGGTC TCTAGTGAGT TAGCTCATGA AAGATGATAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GGTTTTCTGT AGCTACAGAA ATGGGGTTGA GGGTTGGACC AAGGGACTAC CCAGGGGAAG TCTTACCTTC AGAGGACTCT GGAAAGGAGG CTGCAAGTTT TCATGGGTCA AGAATTCAGA GCCCAGTAGA GACAGCTTAT CTCTGTTCCA AGATGTCTGG GGCCTTGGTT GGAAGATTCA AAGGCTAGGA AACCAGGAGC CACCAAAAGC GTAACTGGGG CCAGAGGATC CACTTTCAAG GTGGCAAGTT GGTTCCCCCC ATGTGGCTGC TTGAGTATCC TCACATGGCG GCTCACATCC TTCCAAGTAA GCAATGCAAA AGGCCAAGAA AGATGCTGCA AAGATGTTAT GACCTAGCCT CAGAAATCAC ACACCATCCC TGCCACCATT AGTAAGAAGT CCAGCCCACG TCCAGGAGAA GAGGAAGCAG ATTCCTCCTT TTGAAATGAA GAATATCAAG TAATTCGGGG GGCATATGAA AGCCACCACA CACCACAGGG ATCTTTTTAG AGCATACTTC TTATACCATC ACTGTAGTTC CTTAAGACTC AGGGGCAAAG CCTCACTTCC TTAGCACCCA GTGAAGACCA CGCTTACTCC CTCACTCAAC CTCTTGCTAC TTCCCACCTC TCCTGTCCAA CATCTAGTGT CACTTTCCAG AACATACCAA CAGCTTCCCC AGTTCTGTGC CTCTGCTCAG GCTGTTCCCC CTGCCTGGTC CACTTGTCCT CCTTCTTGTC CGGTCAAAAT GCTTCTTATC CTTCAAGACC CAGCTCTAGA GTCACCTCCA ACCCCTTACC CACCAGCCCC CTCTCCAAGT CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC CACCCTCTGG GCCACAGTTG TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG GTGTCTTCTT TGTGTTCTTG CACTCAGGGC AGAGCTCAGC ACAGAGCAGA CGCTCAAAAA ACATTTAAAG GATAGAAGCA TTGATTTGTG GGTCCCCCAG TCTGGCTCCA GGATGCCAGC CAGCTGCTCC TAGAAGCAAA CGGACTTTTC CTGGGAAATC CCAGAGGTGA TGATCAGTAA TCTCTCCCGT GACTCGTAGT TCAGCTCTTC CTCCATGAGC CTGACTATCA GTGGACCTTC CAGAAAGAGC CCCTTTTCCT TCTCTCACCC ACAGCACAGG GCACTGGGAA AATGCCCAAT GAGTCCTGCC TCTGGGTTGT GCTTTGGACT TTTCAGTGTG TCTCGCATCC ACTCTTCAAC TTGAATGTTG CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATTCAGGATG AGAGCAATAC CCTACTCCAA AGAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAATTTGC CCAAGACCAC ACAGCTAGGA GTGGAACTCA TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GGTAGAGATG AATTACAGCA ACAAGTCTAG AAAGGTGCCT GCCCTATGGT CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA GCCAGTGGGT TAAAGATGAG GTCACCAACA ACGGTGGTGT TGGAGTTTAC CACTGATAAT AAGGGTGCAA AATGTAAATT ACTAATGTTT ATTGAGCCTA GTGCAGTGCG TGGGGCATTT TGCACATTGT CTCTGATCCC TATGACAACC CTGAGAGGTA GTGGTTTTAA CTGCCATGTT ACAGGTGAGG TCATTGTGGT TCAAGGACGT TAAGTAACTT CCCCAGCGTG ACACGGCTTA TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT GGCTGCAAAG TCCCCACCCC CCTCGCCATC TGTATCCTCC AATCACTTCA GTGCTTTGCT GCATAGAAGG TAACGGAAAT CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCTC CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATT TTTCTCTTTT AATAAATTAA CTCACCCACC ACACGGCTTT GAGAGGCTCA AAGTTGACCA ACTCCCTTGG GAGGGCCCCG GTTGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC TTCAAGGAGG TCAAGGGTCC AACACTTGAG ATTGTTAGTG CTGTTGGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC CTCGAGATGA AGAACATGAG GCCCCCGTTT AGAACCAAGG ATCAGAGGGG GCTCTGTAAG ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT CGGCTTCTCC TTGTCCTGGC TGGTTGTCCT TAACCCCTGT CTCCTTCTGG ACCAGTTTTT GTCCTTCCCT TGTGACCGCT GAGGGGTAAC AGCCTCTTTC CACTTTCTTT CAGCGCCGAC ATGCTCAATG TCACCTTGCA AGGGCCCACT CTTAACGGGA CCTTTGCCCA GAGCAAATGC CCCCAAGTGG AGTGGCTGGG CTGGCTCAAC ACCATCCAGC CCCCCTTCCT CTGGGTGCTG TTCGTGCTGG CCACCCTAGA GAACATCTTT GTCCTCAGCG TCTTCTGCCT GCACAAGAGC AGCTGCACGG TGGCAGAGAT CTACCTGGGG AACCTGGCCG CAGCAGACCT GATCCTGGCC TGCGGGCTGC CCTTCTGGGC CATCACCATC TCCAACAACT TCGACTGGCT CTTTGGGGAG ACGCTCTGCC GCGTGGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG CATCTGTTTC CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG ATGCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTGGGGGTG TACGCTGCTC CTGAGCTCAC CCATGCTGGT GTTCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC GTCACCGCTT GTGTCATCAG CTACCCATCC CTCATCTGGG AAGTGTTCAC CAACATGCTC CTGAATGTCG TGGGCTTCCT GCTGCCCCTG AGTGTCATCA CCTTCTGCAC GATGCAGATC ATGCAGGTGC TGCGGAACAA CGAGATGCAG AAGTTCAAGG AGATCCAGAC GGAGAGGAGG GCCACGGTGC TAGTCCTGGT TGTGCTGCTG CTATTCATCA TCTGCTGGCT GCCCTTCCAG ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGGCATCC TCTCCAGCTG CCAGGACGAG CGCATCATCG ATGTAATCAC ACAGATCGCC TCCTTCATGG CCTACAGCAA CAGCTGCCTC AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTTCCGAA AGAAGTCTTG GGAGGTGTAC CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA TTCAGATGGA GAACTCCATG GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTGCA GGACTGGGCA GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA ATTTGTGTAA GGATTGAGGG ACAGTTGCTT TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG AAATGAGTTG ATGTCTCCGG TAAAACACCG EPI-109 241

GAGACTAATT CCTGCCCTGC CCAATTTTGC AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA ACAGCATTAC TGTTCTTATT TGCTGCCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGTG GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA CTGAGCTTCC CTCCCGTGTG TTCTCCGTCC CTGCCCCAGC AAGACAACTT AGATCTCCAG GAGAACTGCC ATCCAGCTTT GGTGCAATGG CTGAGTGCAC AAGTGAGTTG TTGCCCTGGG TTTCTTTAAT CTATTCAGCT AGAACTTTGA AGGACAATTT CTTGCATTAA TAAAGGTTAA GCCCTGAGGG GTCCCTGATA ACAACCTGGA GACCAGGATT TTATGGCTCC CCTCACTGAT GGACAAGGAG GTCTGTGCCA AAGAAGAATC CAATAAGCAC ATATTGAGCA CTTGCTGTAT ATGCAGTATT GAGCACTGTA GGCAAGAGGG AAGAAAGAGA AGGAGCCATC TCCATCTTGA AGGAACTCAA AGACTCAAGT GGGAACGACT GGGCACTGCC ACCACCAGAA AGCTGTTCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA TATGGACAGC AGAAGGGGGA GCCAGGTTCC AGCTCACCAA TACTATTGCA CACCACCTGT CCTGCCTC -3' (FRAG. NO:2275) (SEQ. ID NO:2445)

5'- CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT GCCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTCCCATC CAGCTTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT CTTTAATCTA TTCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA TTGAGCACTT GCTGTATATG CAGTATTGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCTTGAAGG AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTT TTATGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC GGTGTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTT CCACCTGTCA TTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCATTTGGAG AGAAGGCCAT GTCTTCAAAG TCTGATTTGT GATGAGGCAG AGGAAGATAT TTCTAATCGG TCTTGCCCAG AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG GCCTGCTCAG GGACTGTTCC TGTCTCAGCA ACCAAGGGAT TGTTCCTGTC AATCAATGGT TTATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGTGT TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT AAATGAATAT TTATTAGCTG GTTGGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA ACCTAGAAGG GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGTTA GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATTTACAT GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAAT TTTAAAGCAA AAGCGTGAAA AAAAAGATTC CCTCCTTACC CCCAACCCAC TCTTTTTTCC CACCACCCAC TCTCCTCTGC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATTTAGTATT AGTATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC TGTGTTTTGT CACACAGGGC AGTCATTCAG CACCAGAGCA CGTGATGGTC TGAGACTCTC TTAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC TGTCCTGTGA AAGACTCAAT GAGCTGTTAT GTTGTAAACA GGAAGCATTT CACATCCAAA CGAGAAAATC ATGTAAACAT GTGTCTTTTC TGTAGAGCAT AATAAATGGA TGAGGTTTTT GCAAAAAAAA AAAAAAAAA -3' (FRAG. NO:2275) (SEQ. ID NO:2444) 5'- GAGCTCTTCA ATATTTTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA CACACCTTTT CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA CTGGCAAGTC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGTTTCC CTGTCTCCAT GATGATGGGA TCAGGCTTGA TTGCTGGTTT GTAGGCTTGT TATGAATCAA GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTTCC CCAGATCCAC TGGGCCCACT CTTATCTGTT CTCTTCTGAA GGAAGGGTTT TAAGGCTTCA AAAAAAAATG TTTTGAAAGT CCCTGCCCTT TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAAAC TGAGAAAGCC AGCCTGAGCC TTGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGCC ACTGTCGCCC TTGGGAGCCG TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTTTA CACCTTCCGC GTAAACGCCC ACTGTTTACA TCCAAAACTC AGACACAAAA TAACCACCTC AAGAAGATAA ATAATGATAA GAAATAAATG TTACGCGAGG CAAATTTATT CACATGGGGC TTCCCAGGCC ACTTTGTGGT CAGCCGGGAG GGACGTTTTT GCCGTCCCAC GACTCCAACG GGCAGCCGGG CCTACGCAAA CATGGAAATC TTCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCTT CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCTTCAAAG ATGAGCTGTT CCCGCCGCCA CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGAGAAG GTGGGTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AGTTGGGAAA AGTTCCCTTC CTTCCGGAGG GAGG -3' (FRAG. NO:2275) (SEQ. ID NO:2443)

5'- GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGCCC ATGCCGCTTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTTTCCCTG TGGTCGTGGG GAGTT -3' (FRAG. NO:2275) (SEQ. ID NO:2442) 5'- AAATGATAGA CCGTCAATAA TTTGTTAAAT GCTTTTTAAA ATGAATGCTT TAAGCCGGGT GCAGTGCCTC ACATCTGTAA TCCCAGCACT TTGGAGCCGA GCGGGTGGAT TGTGTGAGGT CAGGAGTTCG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCTCTACC AAAAATACAA AAATTAGCCA GGCATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG EPI-109 242

GAGAATCGCT TGAACCCGGG AGGCAAGCTT GCAGTGAGCC AAGATTACGC CATTGTACTC CAGCCTGGGT GACAGAGAGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATTAC GCTTCAAACA CATGATCTCT CACCACTGTT GAATTTTCTT TCTATGAGCC CAGGAGGGCC TCTCAGAGAG GAAAGCTCCT AGGTCTTCCT TTCCCTCTGC AAACTCCCTG CCTTGAAGGT TCAGAAGGAC TGTGCGTGCT CGTTGCATCC TTTGCAAGTG TCCAAACCCT GATCCCAGCT GTGCTTAGGG GTTCCTGCAA ACCTTTTCCA GGTGTTAATT ACCTCCCACT TCATTTCCTG TTTACCAACT CAGCTTTTTG TTTTAGTGTG TTTGAATTCC CTGAACTGAC CGTTGTCTGA TCTCCACCTC CCAACTGAAT TAGGGGAGCT GGGCTTCTGG AAACCCAGGT GCCGGGTGTT GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACACACAC ACCCACATAC CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TTGGACATGC ATAGACCACA GCTTTCCACA CCCTTCCTAG ACAGGGGTCA CTTGGTATCC TGGAGAGAGT GTGAAGTCCT GGAATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA CAAGTCACCA CCAACCCATC TGCGCCTTGT TTACCTCCTC TGTGAGGCAA GCACAGAGCC CATGCCTGCC CCCCTGGATG GGAGTGATGT GAAACTTGAA GGGCGGTCAG AGCAAGGGTC GGGAATGGAA GGCCCTTGGG AAAAAAGGCC CTTTCAACTA GGGGCACAGA GGAGGCCCTG GGCTGAGAAC TTGACAGCAC CTTGTAATTG GTAAGCCAAG CCCGAAGGGA CTGGAAATAC TCAGATGTGT CTGTCTCCCT TATTAGGTTC AAAGTCCCTC AAGACCCTGT CTCCATCACA GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGACCCAA CCAGCCCTAT GGGGTCGCAT CCCCACCTGC CTGGAATTCT CCAAAGAACC TCCCCTTTAA CAGTTCCAGC CTTTAACAGT TCCAGTCTAA ACACATGACC TTTCTCCTCT AAATCAGCCC CCCATCTCTG CCTTTGCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC CCATCCATGT CCAATCAAGC ACTAGGCATG TCAGGTTTAC CCTCTAAACT CCTCTGGAAT CCAGTCTCTC AGTCTCCATC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCTTGCTTC CACTCTACCC CCACTGCAGT CCTGACTTCC TGAGCAGCAG CCAGGGCCTA ATCGATATTC ACACCAAGCG CCAACCTGAC TGAGATATCC TCCTGCACCA TCATCCCTCC ACCCTGTTTA GTTCTGCTCA CCCTCAGTGT TCTCATCAAT AATCCACTCC CCTCACAGGC GCGTTTGGGA CCCCATGTTC TATGCTCTCA CAGGACCTTT TGCTTGATTT TTCACTGTAC TTAGGTCAGT TTGCAGTTAT TAAGTGACTG AGCAATGTCT GGCTTCTCCA GTAGACTGTC AGCTCCTAGC CATTGTATAC CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG AGTCAGGGAC TCAGCAGTCT CCATTTCTCC GCCCTGCTGG AGAATGCGTG TATTTGGCAA TCCCCAGCCC CTGTGCCATC TAACCATCTT TTCTTCTCTG TTCAGCCCAG GTGTGGCCTC ACTCACATCC CACTCTCAGT CCAAATGTTC TCTCCCTGGA AGATATCAAT GTTTCTGTCT GTTCGTGAGG ACTCCGTGCC CACCACGGCC TCTTTCAGGT GAGTCAAAGG GATTCCTCAG TrCACTAGTT AGGGGAGGTG GGCAGACACC CTGGAGAACT CCCTGGAAAG CTCAACTCTC ATGCCCCGGA CAACAGTTGA AGGAACCATG GTGATGTTAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGTTG GAATCTTGGG AGCAGAGGGA ATGTTCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA AGGGCACATT CCTGGTTGTT ATATGTTTCT ATCTATCCCA GATGAACTTG GAAGTGAAGG GAAGAGAGTT AAACATTAAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC CTTGGAAACA AAATATCTCC AACACATGGC TGACATTTGG TGGGAGATCA GAACACCCTA AAGAGAGAAT TTAAGGGGAG GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC AGAGGATAGG GAGATCTGTT CTTGGGGACA GCATTTGCAA GAAACAAGGC TGAGGGGTCC ACTCCAACCT CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGGCCAT CTCAGCTGGG GCCACAGTGC ACTGGACCTA TAGTTTCCAA TTCCGCACTC AGCAGGCATC TTTCTGATGA TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCTTGGCT ACTGTCTTGC TGAGAAATTT ATAAGCAGCA TCTGGTGCTA TACTTTGGTC TCTAGTGAGT TAGCTCATGA AAGATGATAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GGTTTTCTGT AGCTACAGAA ATGGGGTTGA GGGTTGGACC AAGGGACTAC CCAGGGGAAG TCTTACCTTC AGAGGACTCT GGAAAGGAGG CTGCAAGTTT TCATGGGTCA AGAATTCAGA GCCCAGTAGA GACAGCTTAT CTCTGTTCCA AGATGTCTGG GGCCTTGGTT GGAAGATTCA AAGGCTAGGA AACCAGGAGC CACCAAAAGC GTAACTGGGG CCAGAGGATC CACTTTCAAG GTGGCAAGTT GGTTCCCCCC ATGTGGCTGC TTGAGTATCC TCACATGGCG GCTCACATCC TTCCAAGTAA GCAATGCAAA AGGCCAAGAA AGATGCTGCA AAGATGTTAT GACCTAGCCT CAGAAATCAC ACACCATCCC TGCCACCATT AGTAAGAAGT CCAGCCCACG TCCAGGAGAA GAGGAAGCAG ATTCCTCCTT TTGAAATGAA GAATATCAAG TAATTCGGGG GGCATATGAA AGCCACCACA CACCACAGGG ATCTTTTTAG AGCATACTTC TTATACCATC ACTGTAGTTC CTTAAGACTC AGGGGCAAAG CCTCACTTCC TTAGCACCCA GTGAAGACCA CGCTTACTCC CTCACTCAAC CTCTTGCTAC TTCCCACCTC TCCTGTCCAA CATCTAGTGT CACTTTCCAG AACATACCAA CAGCTTCCCC AGTTCTGTGC CTCTGCTCAG GCTGTTCCCC CTGCCTGGTC CACTTGTCCT CCTTCTTGTC CGGTCAAAAT GCTTCTTATC CTTCAAGACC CAGCTCTAGA GTCACCTCCA ACCCCTTACC CACCAGCCCC CTCTCCAAGT CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC CACCCTCTGG GCCACAGTTG TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG GTGTCTTCTT TGTGTTCTTG CACTCAGGGC AGAGCTCAGC ACAGAGCAGA CGCTCAAAAA ACATTTAAAG GATAGAAGCA TTGATTTGTG GGTCCCCCAG TCTGGCTCCA GGATGCCAGC CAGCTGCTCC TAGAAGCAAA CGGACTTTTC CTGGGAAATC CCAGAGGTGA TGATCAGTAA TCTCTCCCGT GACTCGTAGT TCAGCTCTTC CTCCATGAGC CTGACTATCA GTGGACCTTC CAGAAAGAGC CCCTTTTCCT TCTCTCACCC ACAGCACAGG GCACTGGGAA AATGCCCAAT GAGTCCTGCC TCTGGGTTGT GCTTTGGACT TTTCAGTGTG TCTCGCATCC ACTCTTCAAC TTGAATGTTG CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATTCAGGATG AGAGCAATAC CCTACTCCAA AGAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAATTTGC CCAAGACCAC ACAGCTAGGA GTGGAACTCA TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GGTAGAGATG AATTACAGCA ACAAGTCTAG AAAGGTGCCT GCCCTATGGT CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA GCCAGTGGGT TAAAGATGAG GTCACCAACA ACGGTGGTGT TGGAGTTTAC CACTGATAAT AAGGGTGCAA AATGTAAATT ACTAATGTTT ATTGAGCCTA GTGCAGTGCG TGGGGCATTT TGCACATTGT CTCTGATCCC TATGACAACC CTGAGAGGTA GTGGTTTTAA CTGCCATGTT ACAGGTGAGG TCATTGTGGT TCAAGGACGT TAAGTAACTT CCCCAGCGTG ACACGGCTTA TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT GGCTGCAAAG TCCCCACCCC CCTCGCCATC TGTATCCTCC AATCACTTCA GTGCTTTGCT GCATAGAAGG TAACGGAAAT CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCTC CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATT TTTCTCTTIT AATAAATTAA CTCACCCACC ACACGGCTTT GAGAGGCTCA AAGTTGACCA ACTCCCTTGG GAGGGCCCCG GTTGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC TTCAAGGAGG TCAAGGGTCC AACACTTGAG ATTGTTAGTG CTGTTGGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC CTCGAGATGA AGAACATGAG GCCCCCGTTT AGAACCAAGG ATCAGAGGGG GCTCTGTAAG ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT CGGCTTCTCC TTGTCCTGGC TGGTTGTCCT TAACCCCTGT CTCCTTCTGG ACCAGTTTTT GTCCTTCCCT TGTGACCGCT GAGGGGTAAC AGCCTCTTTC CACTTTCTTT CAGCGCCGAC ATGCTCAATG TCACCTTGCA AGGGCCCACT CTTAACGGGA CCTTTGCCCA GAGCAAATGC CCCCAAGTGG AGTGGCTGGG CTGGCTCAAC ACCATCCAGC CCCCCTTCCT CTGGGTGCTG TTCGTGCTGG CCACCCTAGA GAACATCTTT GTCCTCAGCG TCTTCTGCCT GCACAAGAGC AGCTGCACGG TGGCAGAGAT CTACCTGGGG AACCTGGCCG CAGCAGACCT GATCCTGGCC TGCGGGCTGC CCTTCTGGGC CATCACCATC TCCAACAACT TCGACTGGCT CTTTGGGGAG ACGCTCTGCC GCGTGGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG EPI-109 243

CATCTGTTTC CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG ATGCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTGGGGGTG TACGCTGCTC CTGAGCTCAC CCATGCTGGT GTTCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC GTCACCGCTT GTGTCATCAG CTACCCATCC CTCATCTGGG AAGTGTTCAC CAACATGCTC CTGAATGTCG TGGGCTTCCT GCTGCCCCTG AGTGTCATCA CCTTCTGCAC GATGCAGATC ATGCAGGTGC TGCGGAACAA CGAGATGCAG AAGTTCAAGG AGATCCAGAC GGAGAGGAGG GCCACGGTGC TAGTCCTGGT TGTGCTGCTG CTATTCATCA TCTGCTGGCT GCCCTTCCAG ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGGCATCC TCTCCAGCTG CCAGGACGAG CGCATCATCG ATGTAATCAC ACAGATCGCC TCCTTCATGG CCTACAGCAA CAGCTGCCTC AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTTCCGAA AGAAGTCTTG GGAGGTGTAC CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA TTCAGATGGA GAACTCCATG GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTGCA GGACTGGGCA GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA ATTTCTGTAA GGATTGAGGG ACAGTTGCTT TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG AAATGAGTTG ATGTCTCCGG TAAAACACCG GAGACTAATT CCTGCCCTGC CCAATTTTGC AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA ACAGCATTAC TGTTCTTATT TGCTGCCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGTG GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA CTGAGCTTCC CTCCCGTGTG TTCTCCGTCC CTGCCCCAGC AAGACAACTT AGATCTCCAG GAGAACTGCC ATCCAGCTTT GGTGCAATGG CTGAGTGCAC AAGTGAGTTG TTGCCCTGGG TTTCTTTAAT CTATTCAGCT AGAACTTTGA AGGACAATTT CTTGCATTAA TAAAGGTTAA GCCCTGAGGG GTCCCTGATA ACAACCTGGA GACCAGGATT TTATGGCTCC CCTCACTGAT GGACAAGGAG GTCTGTGCCA AAGAAGAATC CAATAAGCAC ATATTGAGCA CTTGCTGTAT ATGCAGTATT GAGCACTGTA GGCAAGAGGG AAGAAAGAGA AGGAGCCATC TCCATCTTGA AGGAACTCAA AGACTCAAGT GGGAACGACT GGGCACTGCC ACCACCAGAA AGCTGTTCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA TATGGACAGC AGAAGGGGGA GCCAGGTTCC AGCTCACCAA TACTATTGCA CACCACCTGT CCTGCCTC -3' (FRAQ. NO: _) (SEQ. ID NO 2441)

5 '-CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT GCCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAGCTTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT CTTTAATCTA TTCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA TTGAGCACTT GCTGTATATG CAGTATTGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCTTGAAGG AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTT TTATGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC GGTGTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTT CCACCTGTCA TTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCATTTGGAG AGAAGGCCAT GTCTTCAAAG TCTGATTTGT GATGAGGCAG AGGAAGATAT TTCTAATCGG TCTTGCCCAG AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG GCCTGCTCAG GGACTGTTCC TGTCTCAGCA ACCAAGGGAT TGTTCCTGTC AATCAATGGT TTATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGTGT TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT AAATGAATAT TTATTAGCTG GTTGGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA ACCTAGAAGG GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGTTA GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATTTACAT GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAAT TTTAAAGCAA AAGCGTGAAA AAAAAGATTC CCTCCTTACC CCCAACCCAC TCTTTTTTCC CACCACCCAC TCTCCTCTGC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATTTAGTATT AGTATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC TGTGTTTTGT CACACAGGGC AGTCATTCAG CACCAGAGCA CGTGATGGTC TGAGACTCTC TTAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC TGTCCTGTGA AAGACTCAAT GAGCTGTTAT GTTGTAAACA GGAAGCATTT CACATCCAAA CGAGAAAATC ATGTAAACAT GTGTCTTTTC TGTAGAGCAT AATAAATGGA TGAGGTTTTT GCAAAAAAAA AAAAAAAAA -3' (FRAQ. NO: _) (SEQ. ID NO 2431) 5'-GGTGBCBTTGBGCBTGTCGGCGC-3' (FRAG. NO:2276) (SEQ. ID NO:2287) 5'-GGTCCCGTTBBGBGTGGGCCC-3' (FRAG. NO:2277) (SEQ. ID NO:2288) 5'-GCCAGCCCAGCCACTCCACTTGGGGGC-3' (FRAG. NO:2278) (SEQ. ID NO:2289) 5'-GGGTGGCCAGCACGAACAGCACCCAGAGGAAGGGGGGC-3' (FRAG. NO:2279) (SEQ. ID NO:2290) 5'-GGCCCAGAAGGGCAGCCCGCAGGCCAGGATCAGGTCTGCTGCGGCC-3' (FRAG. NO:2280) (SEQ. ID NO:2291) 5'-GGAGATAATGGCATTCACCACGCGGC-3' (FRAG. NO:2281) (SEQ. ID NO:2292) 5 -GGCCCAGCGCACGCCGCGCATCCGGCCC-3' (FRAG. NO:2282) (SEQ. ID NO:2293) S'-GGGTTCTGACCTGCAGCCCCC ' (FRAG. NO:2283) (SEQ. ID NO:2294) 5^,-GTCTCCTTGGCATTCCTGGGCCC-3^, (FRAG. NO:2284) (SEQ. ID NO:2295) 5'-CAGTCACTCCTCTCCCTGCCCCC-3' (FRAG. NO:2285) (SEQ. ID NO:2296) 5'-CTTGCTGGGGCAGGGACGG-3' (FRAG. NO:2286) (SEQ. ID NO:2297) 5'-GGTGBCBTTGBGCBTGTCGGCGC-3' (FRAG. NO:2287) (SEQ. ID NO:2298) 5'-GGTCCCGTTBBGBGTGGGCCC-3' (FRAG. NO:2288) (SEQ. ID NO:2299) 5'-GCCAGCCCAGCCACTCCACTTGGGGGC-3' (FRAG. NO:2289) (SEQ. ID NO:2300) EPI-109 244

5'-GGGTGGCCAGCACGAACAGCACCCAGAGGAAGGGGGGC-3' (FRAG. NO:2290) (SEQ. ID NO:2301) 5'-GGCCCAGAAGGGCAGCCCGCAGGCCAGGATCAGGTCTGCTGCGGCC-3' (FRAG. NO:2291) (SEQ. ID NO:2302) 5'-GGAGATAATGGCATTCACCACGCGGC-3' (FRAG. NO:2292) (SEQ. ID NO:2303) 5'-GGCCCAGCGCACGCCGCGCATCCGGCCC-3' (FRAG. NO:2293) (SEQ. ID NO:2304) 5'-GGGTTCTGACCTGCAGCCCCC-3' (FRAG. NO:2294) (SEQ. ID NO:2305) 5'-GTCTCCTTGGCATTCCTGGGCCC-3' (FRAG. NO:2295) (SEQ. ID NO:2306) 5'-CAGTCACTCCTCTCCCTGCCCCC-3' (FRAG. NO:2296) (SEQ. ID NO:2307) 5'-CTTGCTGGGGCAGGGACGG-3' (FRAG. NO:2297) (SEQ. ID NO:2308) 5'-CCGTGTTGTCBGTGGTGCTG-3' (FRAG. NO:2298) (SEQ. ID NO:2309) 5'-CCCGTTTGBGGTBTGGC-3' (FRAG. NO:2299) (SEQ. ID NO:2310) S'-GCTCCBCCBBTTCCCTTTTCTCC-S' (FRAG. NO:2300) (SEQ. ID NO:2311) ₅, _πGT--- _{CCGTTTCTCTTG 3}, _{(FRAG NO:23}oi) (SEQ. ID NO:2312)

5'-CCGTCTGTGGTT-3' (FRAG. NO:2302) (SEQ. ID NO:2313)

32 Adrenergic Receptor Kinase Nucleic Acids and Antisense Oligonucleotide Fragments

5'- GCCGCCGCCG CCAAGATGGC GGACCTGGAG GCGGTGCTGG CCGACGTGAG CTACCTGATG GCCATGGAGA AGAGCAAGGC CACGCCGGCC GCGCGCGCCA GCAAGAAGAT ACTGCTGCCC GAGCCCAGCA TCCGCAGTGT CATGCAGAAG TACCTGGAGG ACCGGGGCGA GGTGACCTTT GAGAAGATCT TTTCCCAGAA GCTGGGGTAC CTGCTCTTCC GAGACTTCTG CCTGAACCAC CTGGAGGAGG CCAGGCCCTT GGTGGAATTC TATGAGGAGA TCAAGAAGTA CGAGAAGCTG GAGACGGAGG AGGAGCGTGT GGCCCGCAGC CGGGAGATCT TCGACTCATA CATCATGAAG GAGCTGCTGG CCTGCTCGCA TCCCTTCTCG AAGAGTGCCA CTGAGCATGT CCAAGGCCAC CTGGGGAAGA AGCAGGTGCC TCCGGATCTC TTCCAGCCAT ACATCGAAGA GATTTGTCAA AACCTCCGAG GGGACGTGTT CCAGAAATTC ATTGAGAGCG ATAAGTTCAC ACGGTTTTGC CAGTGGAAGA ATGTGGAGCT CAACATCCAC CTGACCATGA ATGACTTCAG CGTGCATCGC ATCATTGGGC GCGGGGGCTT TGGCGAGGTC TATGGGTGCC GGAAGGCTGA CACAGGCAAG ATGTACGCCA TGAAGTGCCT GGACAAAAAG CGCATCAAGA TGAAGCAGGG GGAGACCCTG GCCCTGAACG AGCGCATCAT GCTCTCGCTC GTCAGCACTG GGGACTGCCC ATTCATTGTC TGCATGTCAT ACGCGTTCCA CACGCCAGAC AAGCTCAGCT TCATCCTGGA CCTCATGAAC GGTGGGGACC TGCACTACCA CCTCTCCCAG CACGGGGTCT TCTCAGAGGC TGACATGCGC TTCTATGCGG CCGAGATCAT CCTGGGCCTG GAGCACATGC ACAACCGCTT CGTGGTCTAC CGGGACCTGA AGCCAGCCAA CATCCTTCTG GACGAGCATG GCCACGTGCG GATCTCGGAC CTGGGCCTGG CCTGTGACTT CTCCAAGAAG AAGCCCCATG CCAGCGTGGG CACCCACGGG TACATGGCTC CGGAGGTCCT GCAGAAGGGC GTGGCCTACG ACAGCAGTGC CGACTGGTTC TCTCTGGGGT GCATGCTCTT CAAGTTGCTG CGGGGGCACA GCCCCTTCCG GCAGCACAAG ACCAAAGACA AGCATGAGAT CGACCGCATG ACGCTGACGA TGGCCGTGGA GCTGCCCGAC TCCTTCTCCC CTGAACTACG CTCCCTGCTG GAGGGGTTGC TGCAGAGGGA TGTCAACCGG AGATTGGGCT GCCTGGGCCG AGGGGCTCAG GAGGTGAAAG AGAGCCCCTT TTTCCGCTCC CTGGACTGGC AGATGGTCTT CTTGCAGAAG TACCCTCCCC CGCTGATCCC CCCACGAGGG GAGGTGAACG CGGCCGACGC CTTCGACATT GGCTCCTTCG ATGAGGAGGA CACAAAAGGA ATCAAGTTAC TGGACAGTGA TCAGGAGCTC TACCGCAACT TCCCCCTCAC CATCTCGGAG CGGTGGCAGC AGGAGGTGGC AGAGACTGTC TTCGACACCA TCAACGCTGA GACAGACCGG CTGGAGGCTC GCAAGAAAGC CAAGAACAAG CAGCTGGGCC ATGAGGAAGA CTACGCCCTG GGCAAGGACT GCATCATGCA TGGCTACATG TCCAAGATGG GCAACCCCTT CCTGACCCAG TGGCAGCGGC GGTACTTCTA CCTGTTCCCC AACCGCCTCG AGTGGCGGGG CGAGGGCGAG GCCCCGCAGA GCCTGCTGAC CATGGAGGAG ATCCAGTCGG TGGAGGAGAC GCAGATCAAG GAGCGCAAGT GCCTGCTCCT CAAGATCCGC GGTGGGAAAC AGTTCATTTT GCAGTGCGAT AGCGACCCTG AGCTGGTGCA GTGGAAGAAG GAGCTGCGCG ACGCCTACCG CGAGGCCCAG CAGCTGGTGC AGCGGGTGCC CAAGATGAAG AACAAGCCGC GCTCGCCCGT GGTGGAGCTG AGCAAGGTGC CGCTGGTCCA GCGCGGCAGT GCCAACGGCC TCTGACCCGC CCACCCGCCT CCAGGAAGCT ACCTGGAGGA GGTGAGTCTT AGCGGATGAG TAGGAGTTGT CCACGGAGGA AGGTACACAG AAGGGCTTCC AGGCCCAGGA AACAGCAGAG GCACAGAAGT GAGAATGGGT GGGTGAGTTG GTGGGGAAAC TCCAGGTGCA GAGGATGGTA GCGAAACAAA CTGGAGCATT AAGGTCCAAG TCCTCCAAGA TCTTGACTTG CAGATTAAGG AGTTTGTTCA CCTAATCTGC TTTGGGCAGA GTGTGGTGAG TCCTAGAGAC CCCTCTAGGT CTCTCCTCTC AGTAGCCCCA GAAGGCCTGG AGAGCTGCTT CTGGGTGCCA AGCAGGCAGT GACTCCATCA GATCTAGATT TGGGAAAAGC ATCCCTGGTC AGGGCCTGCA TCAGGGCAGT GGCTGGCCAT GAGGACCCTG AGAAGTAGAC AGATTCACGG AGATTCTCAG GAGGCCAGAC AGGAGACTAT GGTGACAAAT TAGATTAGAG AAGGGGAGAG AATGAAGGAG CAGTTGGGGT AAAAGAAAAC TGAGGCTGAC ATGGGTATAT GGGTGGCGAG TGACTCACCA CCCACTGAGA GGAGAACCTC ACAAGCTCTG ACATGCTCTG GTTCCAGGTT CTGTTGGGGC TGATCCAAGA TGGTAGCCTA GAGGTGCACA GAGATGGGGG CCTTGCTTTG CAAAAGGATG CTGGCTGCTG GCCCACAGCA TGGTAATGAG ATTTGAGCTT TATGTGCCCA GGGCTGGGAG GAGGGTCCTG TCACTTTGAA AGCAAAGAGA GGCTCTAGAG AGGGGCATGT TGAGATAGGA ATGCTGCCTT GAGACACCTG GCTTTCCCCA CTCTGGGTGG CTCTCAGCAG GGTGGGTTTC CCCTGCCAGG CAGCACTGAA CCTCTGTGCG CTTCCGGCTG GGAGAGTTTT TACCGTAACT ACATGTGGAA CCATCCTGAA GGAACATCTG GATGGGATGG GGTACAGGGA AGGGAGCTGC CAAGAGTGCT GGCCAGGGAC CTGGGTCTAT GAGCTGGTTG GGGGGTGGGG TTGGGTGCAG GGTACTTGAT CCTGAGTGGG CCTTCTGCGG CCAGGATTGG TTCTAGAGTA GGAGGGGTGG GATCGGGGAT GGGGGAAGCC TGTAACTGCG CTGCAGTTGT CAGGTCCCAG GTTCTGGGTG ACCTACTAAG GATTCTGGGT CCAGTGTGGG TCCCAGGTTA GACGTCCTAG TCCTGAGTCC GTGTCCACAG TTCTGGGTGT TGAGTCTAGG ACAGTGATCT GGAGTTGACA GTCCAATCTA GGTCTGAGTC CTGACCCCAA GTCTAGAGTT CAGGGTCATG GTAGTAGCCT AGGGTCAGAA TCAAGGTTGG GGTCAGTAAC CAGGATGGGA TCGAGGTCAT GGTCCAAAAT CTGGATCTGG GGACCTGTTG GGGGTCTGAG GTGAGTGTCG CAGTCTGGGT ATGGCGTTGG AGACCCAGGG CTGTGATCTG AGGTCATGGT TAGAGTCTCA GGTGGTGGGC CAAGGTTTGA GTCTGGGGTC CTGTTTGGAG TCTGGTGTCA GGTCGTGGAC TGCGTCCAAG GTCAGGGAGT CCGGGGTTAT AGCCAGGGTC TGAGATGAAA GTCCCAGATG GTGTTCAGAG GTCTGAATCT GTGTCTTGGT GAGCGTCCAG GTTCCCTGTG ATCACGTTTG GTGTCAGGGC TGCGGCCCGA CTGGGGAGCC TGGGATCCAG AGATGTGACC CGAGGTTGTG GTCAGAGAAT GGGTCTCGGG TCGTCTTCGT GCCGGGTCCC TGTCGTGTTC CAGGCCCGGG TCTCCGTCCA GCATCGAGGG CCGAGGTCAC GGCCAGGGTC TGAGCCCGCG GTCGCAGGTC TGGTTCGGGG TCAGATTCCG CGCGGCCTCC AGGGGGCGCC GTCGCCGCCC GGCTCGGCCC CTCGCGGGCT CGCTGGCGTT GTGCGCGGCA GGCGGGGCCG EPI-109 245

GAGGCGGCGG CGGCTCCGGG GGCGCGGGCC GGGCGGCGGC GGCGGCGGCG CCCCGACTGC AGTCCCGGCG GGAGCGGAGC GCGAAGCGCG GGGCCGGGCC CGGAGCCGGC GCCATGGGGC GGCGCCGCCT GTGAGCGGCG GCGAGCGGAG CCGCGGGCGC CGAGCAGGGC CAGGCGGGAG CGTCGGCGCC CGAGGCCGAG CGAGCCGCGG CCGGGCCGGG CCGAGCGCCG AGCGAGCAGG AGCGGCGGCG GCGGCGGCGG CGGCGGGAGG AGGCAGCGCC GCCGCCAAGA TGGCGGACCT GGAGGCGGTG CTGGCCGACG TGAGCTACCT GATGGCCATG GAGAAGAGCA AGGCCACGCC GGCCGCGCGC GCCAGCAAGA AGATACTGCT GCCCGAGCCC AGGTGAGGAG AAGCT-3' (FRAG. NO:_) (SEQ. ED NO:2430)

5*-CCAGGAAGCT ACCTGGAGGA GGTGAGTCTT AGCGGATGAG TAGGAGTTGT CCACGGAGGA AGGTACACAG AAGGGCTTCC AGGCCCAGGA AACAGCAGAG GCACAGAAGT GAGAATGGGT GGGTGAGTTG GTGGGGAAAC TCCAGGTGCA GAGGATGGTA GCGAAACAAA CTGGAGCATT AAGGTCCAAG TCCTCCAAGA TCTTGACTTG CAGATTAAGG AGTTTGTTCA CCTAATCTGC TTTGGGCAGA GTGTGGTGAG TCCTAGAGAC CCCTCTAGGT CTCTCCTCTC AGTAGCCCCA GAAGGCCTGG AGAGCTGCTT CTGGGTGCCA AGCAGGCAGT GACTCCATCA GATCTAGATT TGGGAAAAGC ATCCCTGGTC AGGGCCTGCA TCAGGGCAGT GGCTGGCCAT GAGGACCCTG AGAAGTAGAC AGATTCACGG AGATTCTCAG GAGGCCAGAC AGGAGACTAT GGTGACAAAT TAGATTAGAG AAGGGGAGAG AATGAAGGAG CAGTTGGGGT AAAAGAAAAC TGAGGCTGAC ATGGGTATAT GGGTGGCGAG TGACTCACCA CCCACTGAGA GGAGAACCTC ACAAGCTCTG ACATGCTCTG GTTCCAGGTT CTGTTGGGGC TGATCCAAGA TGGTAGCCTA GAGGTGCACA GAGATGGGGG CCTTGCTTTG CAAAAGGATG CTGGCTGCTG GCCCACAGCA TGGTAATGAG ATTTGAGCTT TATGTGCCCA GGGCTGGGAG GAGGGTCCTG TCACTTTGAA AGCAAAGAGA GGCTCTAGAG AGGGGCATGT TGAGATAGGA ATGCTGCCTT GAGACACCTG GCTTTCCCCA CTCTGGGTGG CTCTCAGCAG GGTGGGTTTC CCCTGCCAGG CAGCACTGAA CCTCTGTGCG CTTCCGGCTG GGAGAGTTTT TACCGTAACT ACATGTGGAA CCATCCTGAA GGAACATCTG GATGGGATGG GGTACAGGGA AGGGAGCTGC CAAGAGTGCT GGCCAGGGAC CTGGGTCTAT GAGCTGGTTG GGGGGTGGGG TTGGGTGCAG GGTACTTGAT CCTGAGTGGG CCTTCTGCGG CCAGGATTGG TTCTAGAGTA GGAGGGGTGG GATCGGGGAT GGGGGAAGCC TGTAACTGCG CTGCAGTTGT CAGGTCCCAG GTTCTGGGTG ACCTACTAAG GATTCTGGGT CCAGTGTGGG TCCCAGGTTA GACGTCCTAG TCCTGAGTCC GTGTCCACAG TTCTGGGTGT TGAGTCTAGG ACAGTGATCT GGAGTTGACA GTCCAATCTA GGTCTGAGTC CTGACCCCAA GTCTAGAGTT CAGGGTCATG GTAGTAGCCT AGGGTCAGAA TCAAGGTTGG GGTCAGTAAC CAGGATGGGA TCGAGGTCAT GGTCCAAAAT CTGGATCTGG GGACCTGTTG GGGGTCTGAG GTGAGTGTCG CAGTCTGGGT ATGGCGTTGG AGACCCAGGG CTGTGATCTG AGGTCATGGT TAGAGTCTCA GGTGGTGGGC CAAGGTTTGA GTCTGGGGTC CTGTTTGGAG TCTGGTGTCA GGTCGTGGAC TGCGTCCAAG GTCAGGGAGT CCGGGGTTAT AGCCAGGGTC TGAGATGAAA GTCCCAGATG GTGTTCAGAG GTCTGAATCT GTGTCTTGGT GAGCGTCCAG GTTCCCTGTG ATCACGTTTG GTGTCAGGGC TGCGGCCCGA CTGGGGAGCC TGGGATCCAG AGATGTGACC CGAGGTTGTG GTCAGAGAAT GGGTCTCGGG TCGTCTTCGT GCCGGGTCCC TGTCGTGTTC CAGGCCCGGG TCTCCGTCCA GCATCGAGGG CCGAGGTCAC GGCCAGGGTC TGAGCCCGCG GTCGCAGGTC TGGTTCGGGG TCAGATTCCG CGCGGCCTCC AGGGGGCGCC GTCGCCGCCC GGCTCGGCCC CTCGCGGGCT CGCTGGCGTT GTGCGCGGCA GGCGGGGCCG GAGGCGGCGG CGGCTCCGGG GGCGCGGGCC GGGCGGCGGC GGCGGCGGCG CCCCGACTGC AGTCCCGGCG GGAGCGGAGC GCGAAGCGCG GGGCCGGGCC CGGAGCCGGC GCCATGGGGC GGCGCCGCCT GTGAGCGGCG GCGAGCGGAG CCGCGGGCGC CGAGCAGGGC CAGGCGGGAG CGTCGGCGCC CGAGGCCGAG CGAGCCGCGG CCGGGCCGGG CCGAGCGCCG AGCGAGCAGG AGCGGCGGCG GCGGCGGCGG CGGCGGGAGG AGGCAGCGCC GCCGCCAAGA TGGCGGACCT GGAGGCGGTG CTGGCCGACG TGAGCTACCT GATGGCCATG GAGAAGAGCA AGGCCACGCC GGCCGCGCGC GCCAGCAAGA AGATACTGCT GCCCGAGCCC AGGTGAGGAG AAGCT-3' (FRAG. NO:_) (SEQ. ED NO:2429)

5'-GCCGCCGCCG CCAAGATGGC GGACCTGGAG GCGGTGCTGG CCGACGTGAG CTACCTGATG GCCATGGAGA AGAGCAAGGC CACGCCGGCC GCGCGCGCCA GCAAGAAGAT ACTGCTGCCC GAGCCCAGCA TCCGCAGTGT CATGCAGAAG TACCTGGAGG ACCGGGGCGA GGTGACCTTT GAGAAGATCT TTTCCCAGAA GCTGGGGTAC CTGCTCTTCC GAGACTTCTG CCTGAACCAC CTGGAGGAGG CCAGGCCCTT GGTGGAATTC TATGAGGAGA TCAAGAAGTA CGAGAAGCTG GAGACGGAGG AGGAGCGTGT GGCCCGCAGC CGGGAGATCT TCGACTCATA CATCATGAAG GAGCTGCTGG CCTGCTCGCA TCCCTTCTCG AAGAGTGCCA CTGAGCATGT CCAAGGCCAC CTGGGGAAGA AGCAGGTGCC TCCGGATCTC TTCCAGCCAT ACATCGAAGA GATTTGTCAA AACCTCCGAG GGGACGTGTT CCAGAAATTC ATTGAGAGCG ATAAGTTCAC ACGGTTTTGC CAGTGGAAGA ATGTGGAGCT CAACATCCAC CTGACCATGA ATGACTTCAG CGTGCATCGC ATCATTGGGC GCGGGGGCTT TGGCGAGGTC TATGGGTGCC GGAAGGCTGA CACAGGCAAG ATGTACGCCA TGAAGTGCCT GGACAAAAAG CGCATCAAGA TGAAGCAGGG GGAGACCCTG GCCCTGAACG AGCGCATCAT GCTCTCGCTC GTCAGCACTG GGGACTGCCC ATTCATTGTC TGCATGTCAT ACGCGTTCCA CACGCCAGAC AAGCTCAGCT TCATCCTGGA CCTCATGAAC GGTGGGGACC TGCACTACCA CCTCTCCCAG CACGGGGTCT TCTCAGAGGC TGACATGCGC TTCTATGCGG CCGAGATCAT CCTGGGCCTG GAGCACATGC ACAACCGCTT CGTGGTCTAC CGGGACCTGA AGCCAGCCAA CATCCTTCTG GACGAGCATG GCCACGTGCG GATCTCGGAC CTGGGCCTGG CCTGTGACTT CTCCAAGAAG AAGCCCCATG CCAGCGTGGG CACCCACGGG TACATGGCTC CGGAGGTCCT GCAGAAGGGC GTGGCCTACG ACAGCAGTGC CGACTGGTTC TCTCTGGGGT GCATGCTCTT CAAGTTGCTG CGGGGGCACA GCCCCTTCCG GCAGCACAAG ACCAAAGACA AGCATGAGAT CGACCGCATG ACGCTGACGA TGGCCGTGGA GCTGCCCGAC TCCTTCTCCC CTGAACTACG CTCCCTGCTG GAGGGGTTGC TGCAGAGGGA TGTCAACCGG AGATTGGGCT GCCTGGGCCG AGGGGCTCAG GAGGTGAAAG AGAGCCCCTT TTTCCGCTCC CTGGACTGGC AGATGGTCTT CTTGCAGAAG TACCCTCCCC CGCTGATCCC CCCACGAGGG GAGGTGAACG CGGCCGACGC CTTCGACATT GGCTCCTTCG ATGAGGAGGA CACAAAAGGA ATCAAGTTAC TGGACAGTGA TCAGGAGCTC TACCGCAACT TCCCCCTCAC CATCTCGGAG CGGTGGCAGC AGGAGGTGGC AGAGACTGTC TTCGACACCA TCAACGCTGA GACAGACCGG CTGGAGGCTC GCAAGAAAGC CAAGAACAAG CAGCTGGGCC ATGAGGAAGA CTACGCCCTG GGCAAGGACT GCATCATGCA TGGCTACATG TCCAAGATGG GCAACCCCTT CCTGACCCAG TGGCAGCGGC GGTACTTCTA CCTGTTCCCC AACCGCCTCG AGTGGCGGGG CGAGGGCGAG GCCCCGCAGA GCCTGCTGAC CATGGAGGAG ATCCAGTCGG TGGAGGAGAC GCAGATCAAG GAGCGCAAGT GCCTGCTCCT CAAGATCCGC GGTGGGAAAC AGTTCATTTT GCAGTGCGAT AGCGACCCTG AGCTGGTGCA GTGGAAGAAG GAGCTGCGCG ACGCCTACCG CGAGGCCCAG CAGCTGGTGC AGCGGGTGCC CAAGATGAAG AACAAGCCGC GCTCGCCCGT GGTGGAGCTG AGCAAGGTGC CGCTGGTCCA GCGCGGCAGT GCCAACGGCC TCTGACCCGC CCACCCGCCT-3' (FRAG. NO: ) (SEQ. ID NO:2428) CCR-2 CC Chemokine Receptor Nucleic Acids and Antisense Oligonucleotide Fragments 5'-CTTTGTGAAG AAGGAATTGG CAACACTGAA ACCTCCAGAA CAAAGGCTGT CACTAAGGTC CCGCTGCCTT GATGGATTAT ACACTTGACC TCAGTGTGAC AACAGTGACC GACTACTACT ACCCTGATAT CTTCTCAAGC CCCTGTGATG CGGAACTTAT TCAGACAAAT GGCAAGTTGC TCCTTGCTGT CTTTTATTGC CTCCTGTTTG TATTCAGTCT TCTGGGAAAC AGCCTGGTCA TCCTGGTCCT TGTGGTCTGC AAGAAGCTGA GGAGCATCAC AGATGTATAC CTCTTGAACC TGGCCCTGTC EPI-109 246

TGACCTGCTT TTTGTCTTCT CCTTCCCCTT TCAGACCTAC TATCTGCTGG ACCAGTGGGT GTTTGGGACT GTAATGTGCA AAGTGGTGTC TGGCTTTTAT TACATTGGCT TCTACAGCAG CATGTTTTTC ATCACCCTCA TGAGTGTGGA CAGGTACCTG GCTGTTGTCC ATGCCGTGTA TGCCCTAAAG GTGAGGACGA TCAGGATGGG CACAACGCTG TGCCTGGCAG TATGGCTAAC CGCCATTATG GCTACCATCC CATTGCTAGT GTTTTACCAA GTGGCCTCTG AAGATGGTGT TCTACAGTGT TATTCATTTT ACAATCAACA GACTTTGAAG TGGAAGATCT TCACCAACTT CAAAATGAAC ATTTTAGGCT TGTTGATCCC ATTCACCATC TTTATGTTCT GCTACATTAA AATCCTGCAC CAGCTGAAGA GGTGTCAAAA CCACAACAAG ACCAAGGCCA TCAGGTTGGT GCTCATTGTG GTCATTGCAT CTTTACTTTT CTGGGTCCCA TTCAACGTGG TTCTTTTCCT CACTTCCTTG CACAGTATGC ACATCTTGGA TGGATGTAGC ATAAGCCAAC AGCTGACTTA TGCCACCCAT GTCACAGAAA TCATTTCCTT TACTCACTGC TGTGTGAACC CTGTTATCTA TGCTTTTGTT GGGGAGAAGT TCAAGAAACA CCTCTCAGAA ATATTTCAGA AAAGTTGCAG CCAAATCTTC AACTACCTAG GAAGACAAAT GCCTAGGGAG AGCTGTGAAA AGTCATCATC CTGCCAGCAG CACTCCTCCC GTTCCTCCAG CGTAGACTAC ATTTTGTGAG GATCAATGAA GACTAAATAT AAAAAACATT TTCTTGAATG GCATGCTAGT AGCAGTGAGC AAAGGTGTGG GTGTGAAAGG TTTCCAAAAA AAGTTCAGCA TGAAGGATGC CGTGTGTGTT GTTGCCAACA CTTGGAACAC AATGACTGGA GACATAGTTG TGCATGCCTG GCACAACATC AAGCCTGTGA TTGTGTTTAT TGATGATGTT GAACAAGTGG TGGCTTTGAG GGATTCTGTA TGCCAAGTGG AAAAAAAAGA TGTCTCCGGA ATTCGACAGG TTATCA-3' (FRAG. NO: ) (SEQ. ID NO:2462)

CCR-4 CC Chemokine Receptor Nucleic Acids and Antisense Oligonucleotide Fragments 5'-TTTCATCTCT CCGGGCTTAT TTGCTGGTTT CTCCGAATGC GGGCCTTGTC TGGTTCACGC TGGATCCCCA ACGCCTAGAA CAGTGCGTGG CACGCAGTTC GTCCTTCTAT AAATATCGGA CTAAATGCAT CTCTGTGATG GTAATACCCA CACGGTGTTG TGAGAATGAA TGAGTGATTC TGTGCAAGTT CCTAGTGATC TGTTACAAAA AGTACTGGTC GCTAAATTAC TCTTATAATA AAGCATACTT TTAGGATAAT AAAGCACTAT TCGCGAATTG GTTACCGCTA TTATGAAATT ACTGAGCAAT ACATATCTAC ATCTGATCAG TCTCCAGAAT TATGCCAAAT CCTACCTTCT TCTGAAAGTA TCTCCTAATT ATCTGCACCT GACCCTAGTG ATGCTGTGAA TGTGCAAGTA TAGCTACATC CTCCGAAGGA AGGATCTTTA CTCCTTTTAC CTCCTGAATG GGCTGCGTCT GCTGAAAGCG CGGGGGAATG GGCGGTTGGA AGCTTGGCCC TACTTCCAGC ATTGCCGCCT ACTGGTTGGG TTACTCCAGC AAGTCACTCC CCTTCCCTGG GCCTCAGTGT CTCTACTGTA GCATTCCCAG GTCTGGAATT CCATCCACTT TAGCAAGGAT GGACGCGCCA CAGAGAGACG CGTTCCTAGC CCGCGCTTCC CACCTGTCTT CAGGCGCATC CCGCTTCCCT CAAACTTAGG AAATGCCTCT GGGAGGTCCT GTCCGGCTCC GGACTCACTA CCGACCACCC GCAAACAGCA GGGTCCCCTG GGCTTCCCAA GCCGCGCACC TCTCCGCCCC GCCCCTGCGC CCTCCTTCCT CGCGTCTGCC CCTCTCCCCC ACCCCGCCTT CTCCCTCCCC GCCCCAGCGG CGCATGCGCC GCGCTCGGAG CGTGTTTTTA TAAAAGTCCG GCCGCGGCCA GAAACTTCAG TTTGTTGGCT GCGGCAGCAG GTAGCAAAGT GACGCCGAGG GCCTGAGTGC TCCAGTAGCC ACCGCATCTG GAGAACCAGC GGTTACCATG GAGGGGATCA GTGTAAGTCC AGTTTCAACC TGCTTTGTCA TAAATGTACA AACGTTTGAA CTTAGAGCGC AGCCCCTCTC CGAGCGGGCA GAAGCGGCCA GGACATTGGA GGTACCCGTA CTCCAAAAAA GGGTCACCGA AAGGAGTTTT CTTGACCATG CCTATATAGT GCGGGTGGGT GGGGGGGGAG CAGGATTGGA ATCTTTTTCT CTGTGAGTCG AGGAGAAACG ACTGGAAAGA GCGTTCCAGT GGCTGCATGT GTCTCCCCCT TGAGTCCCGC CGCGCGCGGC GGCTTGCACG CTGTTTGCAA ACGTAAGAAC ATTCTGTGCA CAAGTGCAGA GAAGGCGTGC GCGCTGCCTC GGGACTCAGA CCACCGGTCT CTTCCTTGGG GAAGCGGGGA TGTCTTGGAG CGAGTTACAT TGTCTGAATT TAGAGGCGGA GGGCGGCGTG CCTGGGCTGA CTTCCCAGGA GGAGATTGCG CCCGCTTTAA CTTCGGGGTT AAGCGCCTGG TGACTGTTCT TGACACTGGG TGCGTGTTTG TTAAACTCTG TGCGGCCGAC GGAGCTGTGC CAGTCTCCCA GCACAGTAGG CAGAGGGCGG GAGAGGCGGG TGGACCCACC GCGCCGATCC TCTCAGGGGA TCGAGTGGTG GCAGCAGCTA GGAGTTGATC CGCCCGCGCG CTTTGGGTTT GAGGGGGAAA CCTTCCCGCC GTCCGAAGCG CGCCTCTTCC CCACGGCCGC GAGTGGGTCC TGCAGTTCGA GAGTTTGGGG TCGTGCAGAG GTCAGCGGAG TGGTTTGACC TCCCCTTTGA CACCGCGCAG CTGCCAGCCC TGAGATTTGC GCTCCGGGGA TAGGAGCGGG TACGGGGTGA GGGGCGGGGG CGGTTAAGAC CGCACCTGGG CTGCCAGGTC GCCGCCGCGA AGACTGGCAG GTGCAAGTGG GGAAACCGTT TGGCTCTCTC CGAGTCCAGT TGTGATGTTT AACCGTCGGT GGTTTCCAGA AACCTTTTGA AACCCTCTTG CTAGGGAGTT TTTGGTTTCC TGCAGCGGCG CGCAATTCAA AGACGCTCGC GGCGGAGCCG CCCAGTCGCT CCCCAGCACC CTGTGGGACA GAGCCTGGCG TGTCGCCCAG CGGAGCCCCT GCAGCGCTGC TTGCGGGCGG TTGGCGTGGG TGTAGTGGGC AGCCGCGGCG GCCCGGGGCT GGACGACCCG GCCCCCCGCG TGCCCACCGC CTGGAGGCTT CCAGCTGCCC ACCTCCGGCC GGGTTAACTG GATCAGTGGC GGGGTAATGG GAAGCCACCC GGGAGAGTGA GGAAATGAAA CTTGGGGCGA GGACCACGGG TGCAGACCCC GTTACCTTCT CCACCCAGGA AAATGCCCCG CTCCCTAACG TCCCAAACGC GCCAAGTGAT AAACACGAGG ATGGCAAGAG ACCCACACAC CGGAGGAGCG CCCGCTTGGG GGAGGAGGTG CCGTTTGTTC ATTTTCTGAC ACTCCCGCCC AATATACCCC AAGCACCGAA GGGCCTTCGT TTTAAGACCG CATTCTCTTT ACCCACTACA AGTTGCTTGA AGCCCAGAAT GGTTTGTATT TAGGCAGGCG TGGGAAAATT AAGTTTTTGC GCTTTAGGAG AATGAGTCTT TGCAACGCCC CCGCCCTCCC CCCGTGATCC TCCCTTCTCC CCTCTTCCCT CCCTGGGCGA AAAACTTCTT ACAAAAAGTT AATCACTGCC CCTCCTAGCA GCACCCACCC CACCCCCCAC GCCGCCTGGG AGTGGCCTCT TTGTGTGTAT TTTTTTTTTC CTCCTAAGGA AGGTTTTTTT TCTTCCCTCT AGTGGGCGGG GCAGAGGAGT TAGCCAAGAT GTGACTTTGA AACCCTCAGC GTCTCAGTGC CCTTTTGTTC TAAACAAAGA ATTTTGTAAT TGGTTCTACC AAAGAAGGAT ATAATGAAGT CACTATGGGA AAAGATGGGG AGGAGAGTTG TAGGATTCTA CATTAATTCT CTTGTGCCCT TAGCCCACTA CTTCAGAATT TCCTGAAGAA AGCAAGCCTG AATTGGTTTT TTAAATTGCT TTAAAAATTT TTTTTAACTG GGTTAATGCT TGCTGAATTG GAAGTGAATG TCCATTCCTT TGCCTCTTTT GCAGATATAC ACTTCAGATA ACTACACCGA GGAAATGGGC TCAGGGGACT ATGACTCCAT GAAGGAACCC TGTTTCCGTG AAGAAAATGC TAATTTCAAT AAAATCTTCC TGCCCACCAT CTACTCCATC ATCTTCTTAA CTGGCATTGT GGGCAATGGA TTGGTCATCC TGGTCATGGG TTACCAGAAG AAACTGAGAA GCATGACGGA CAAGTACAGG CTGCACCTGT CAGTGGCCGA CCTCCTCTTT GTCATCACGC TTCCCTTCTG GGCAGTTGAT GCCGTGGCAA ACTGGTACTT TGGGAACTTC CTATGCAAGG CAGTCCATGT CATCTACACA GTCAACCTCT ACAGCAGTGT CCTCATCCTC GCCTTCATCA GTCTGGACCG CTACCTGGCC ATCGTCCACG CCACCAACAG TCAGAGGCCA AGGAAGCTGT TGGCTGAAAA GGTGGTCTAT GTTGGCGTCT GGATCCCTGC CCTCCTGCTG ACTATTCCCG ACTTCATCTT TGCCAACGTC AGTGAGGCAG ATGACAGATA TATCTGTGAC CGCTTCTACC CCAATGACTT GTGGGTGGTT GTGTTCCAGT TTCAGCACAT CATGGTTGGC CTTATCCTGC CTGGTATTGT CATCCTGTCC TGCTATTGCA TTATCATCTC CAAGCTGTCA CACTCCAAGG GCCACCAGAA GCGCAAGGCC CTCAAGACCA CAGTCATCCT CATCCTGGCT TTCTTCGCCT GTTGGCTGCC TTACTACATT GGGATCAGCA TCGACTCCTT CATCCTCCTG GAAATCATCA AGCAAGGGTG TGAGTTTGAG AACACTGTGC ACAAGTGGAT TTCCATCACC GAGGCCCTAG CTTTCTTCCA CTGTTGTCTG AACCCCATCC TCTATGCTTT CCTTGGAGCC AAATTTAAAA CCTCTGCCCA GCACGCACTC ACCTCTGTGA GCAGAGGGTC CAGCCTCAAG ATCCTCTCCA AAGGAAAGCG AGGTGGACAT TCATCTGTTT CCACTGAGTC TGAGTCTTCA AGTTTTCACT CCAGCTAACA CAGATGTAAA EPI-109 247

AGACTTTTTT TTATACGATA AATAACTTTT TTTTAAGTTA CACATTTTTC AGATATAAAA GACTGACCAA TATTGTACAG TTTTTATTGC TTGTTGGATT TTTGTCTTGT GTTTCTTTAG TTTTTGTGAA GTTTAATTGA CTTATTTATA TAAATTTTTT TTGTTTCATA TTGATGTGTG TCTAGGCAGG ACCTGTGGCC AAGTTCTTAG TTGCTGTATG TCTCGTGGTA GGACTGTAGA AAAGGGAACT GAACATTCCA GAGCGTGTAG TGAATCACGT AAAGCTAGAA ATGATCCCCA GCTGTTTATG CATAGATAAT CTCTCCATTC CCGTGGAACG TTTTTCCTGT TCTTAAGACG TGATTTTGCT GTAGAAGATG GCACTTATAA CCAAAGCCCA AAGTGGTATA GAAATGCTGG TTTTTCAGTT TTCAGGAGTG GGTTGATTTC AGCACCTACA GTGTACAGTC TTGTATTAAG TTGTTAATAA AAGTACATGT TAAACTTACT TAGTGTTATG TTCTGATTTC TGTTGACATT CTTTTGGCTA GTAGAAGACA AAAGTAATAC ATTTATGGTA TGCAAAGCAC TATCCTAGGT ATTTCATTGT AATATTTTAC TTACCCCTTA TCACAACTCT GATAGATTCT GCTTCTGTTA CTAATTACAT TTTATAGAAG AGGAAACGGA GGCACAGAAA GCCTAAGTAA CTTGGTTAAA GGCATGTAGT AAGTATCAAA TCCTGTATTT TAAACCAGGT AACATGACTT AACGAATCTG AAGCCTTCAC CACTTTAAAT TCAAATGGAA GTTTAGAAAT GGCCAGCCAG CACCTATTTG TATGAAAGGT CATCTTTCAG AGGATAAGCA TGTATAAAGA AGAAAAGGTA TGCAGTCGTG TTTGGATTTT ACTCCACCAT C-3' (FRAG. NO: (SEQ. ID NO: 2463) CD-34 Nucleic Acids and Antisense Oligonucleotide Fragments

5'-AGGATGATGG TGATGGGGAA CTAAATGGGG AAATATGGAA GGTCACAGGA AAAGTTAACA CAAGTTAGCA AAAGTTAAC ATAACACAAA AAGGTCTTGC AGGAAAAAAA AAAGAAAAGA AAAGAAAGAA AAAGTCTCCA AGAATGGTTT GGACAGCCAA AATGAATACT TATAGTCACG TATACCTGCT CACTCCTGAC GCTTCACTCA CACACAGCAC AGGATCTGGT GAGGCTATCA TAAATGTGC CACATTGTGG TTAAGTTTTA CCTGATTAAC GAAATGCTCA CACTTCTAAA CTGAGGTCCT TACAGTAGAT TCCTTTTGCA AGATTGTTAC TGGCTTACAA CTTAAAAATA AAGGAAAATC ACAAGGAAAG AAAAGTGGGG AAAAAATCGG AGGAAACTTG CCCCTGCCCT GGCCACCGGC AAGGCTGCCA CAAAGGGGTT AAAAGTTAAG TGGAAGTGGA GCTTGAAGAA GTGGGATGGG GCCTCTCCAG GAAAGCTGAA CGAGGCATCT GGAGCCCGAA CAAACCTCCA CCTTTTTTGG CCTCGACGGC GGCAACCCAG CCTCCCTCCT AACGCCCTCC GCCTTTGGGA CCAACCAGGG GAGCTCAAGT TAGTAGCAGC CAAGGAGAGG CGCTGCCTTG CCAAGACTAA AAAGGGAGGG GAGAAGAGAG GAAAAAAGCA AGAATCCCCC ACCCCTCTCC CGGGCGGAGG GGGCGGGAAG AGCGCGTCCT GGCCAAGCCG AGTAGTGTCT TCCACTCGGT GCGTCTCTCT AGGAGCCGCG CGGGAAGGAT GCTGGTCCGC AGGGGCGCGC GCGCAGGGCC CAGGATGCCG CGGGGCTGGA CCGCGCTTTG CTTGCTGAGT TTGCTGC CCTTTTTTGG CCTCGACGGC GGCAACCCAG CCTCCCTCCT AACGCCCTCC GCCTTTGGGA CCAACCAGGG GAGCTCAAGT TAGTAGCAGC CAAGGAGAGG CGCTGCCTTG CCAAGACTAA AAAGGGAGGG GAGAAGAGAG GAAAAAAGCA AGAATCCCCC ACCCCTCTCC CGGGCGGAGG GGGCGGGAAG AGCGCGTCCT GGCCAAGCCG AGTAGTGTCT TCCACTCGGT GCGTCTCTCT AGGAGCCGCG CGGGAAGGAT GCTGGTCCGC AGGGGCGCGC GCGAGGGCCC AGGATGCCGC GGGGCTGGAC CGCGCTTTGC TTGCTGAGTT TGCTGCCTTC TGGGTTCATG AGTCTTGACA ACAACGGTAC TGCTACCCCA GAGTTACCTA CCCAGGGAAC ATTTTCAAAT GTTTCTACAA ATGTATCCTA CCAAGAAACT ACAACACCTA GTACCCTTGG AAGTACCAGC CTGCACCCTG TGTCTCAACA TGGCAATGAG GCCACAACAA ACATCACAGA AACGACAGTC AAATTCACAT CTACCTCTGT GATAACCTCA GTTTATGGAA ACACAAACTC TTCTGTCCAG TCACAGACCT CTGTAATCAG CACAGTGTTC ACCACCCCAG CCAACGTTTC AACTCCAGAG ACAACCTTGA AGCCTAGCCT GTCACCTGGA AATGTTTCAG ACCTTTCAAC CACTAGCACT AGCCTTGCAA CATCTCCCAC TAAACCCTAT ACATCATCTT CTCCTATCCT AAGTGACATC AAGGCAGAAA TCAAATGTTC AGGCATCAGA GAAGTGAAAT TGACTCAGGG CATCTGCCTG GAGCAAAATA AGACCTCCAG CTGTGCGGAG TTTAAGAAGG ACAGGGGAGA GGGCCTGGCC CGAGTGCTGT GTGGGGAGGA GCAGGCTGAT GCTGATGCTG GGGCCCAGGT ATGCTCCCTG CTCCTTGCCC AGTCTGAGGT GAGGCCTCAG TGTCTACTGC TGGTCTTGGC CAACAGAACA GAAATTTCCA GCAAACTCCA ACTTATGAAA AAGCACCAAT CTGACCTGAA AAAGCTGGGG ATCCTAGATT TCACTGAGCA AGATGTTGCA AGCCACCAGA GCTATTCCCA AAAGACCCTG ATTGCACTGG TCACCTCGGG AGCCCTGCTG GCTGTCTTGG GCATCACTGG CTATTTCCTG ATGAATCGCC GCAGCTGGAG CCCCACAGGA GAAAGGCTGG GCGAAGACCC TTATTACACG GAAAACGGTG GAGGCCAGGG CTATAGCTCA GGACCTGGGA CCTCCCCTGA GGCTCAGGGA AAGGCCAGTG TGAACCGAGG GGCTCAGAAA AACGGGACCG GCCAGGCCAC CTCCAGAAAC GGCCATTCAG CAAGACAACA CGTGGTGGCT GATACCGAAT TGTGACTCGG CTAGGTGGGG CAAGGCTGGG CAGTGTCCGA GAGAGCACCC CTCTCTGCAT CTGACCACGT GCTACCCCCA TGCTGGAGGT GACATCTCTT ACGCCCAACC CTTCCCCACT GCACACACCT CAGAGGCTGT TCTTGGGGCC CTACACCTTG AGGAGGGGGC AGGTAAACTC CTGTCCTTTA CACATTCGGC TCCCTGGAGC CAGACTCTGG TCTTCTTTGG GTAAACGTGT GACGGGGGAA AGCCAAGGTC TGGAGAAGCT CCCAGGAACA ATCGATGGCC TTGCAGCACT CACACAGGAC CCCCTTCCCC TACCCCCTCC TCTCTGCCGC AATACAGGAA CCCCCAGGGG AAAGATGAGC TTTTCTAGGC TACAATTTTC TCCCAGGAAG CTTTGATTTT TACCGTTTCT TCCCTGTATT TTCTTTCTCT ACTTTGAGGA AACCAAAGTA ACCTTTTGCA CCTGCTCTCT TGTAATGATA TAGCCAGAAA AACGTGTTGC CTTGAACCAC TTCCCTCATC TCTCCTCCAA GACACTGTGG ACTTGGTCAC CAGCTCCTCC CTTGTTCTCT AAGTTCCACT GAGCTCCATG TGCCCCCTCT ACCATTTGCA GAGTCCTGCA CAGTTTTCTG GCTGGAGCCT AGAACAGGCC TCCCAAGTTT TAGGACAAAC AGCTCAGTTC TAGTCTCTCT GGGGCCACAC AGAAACTCTT TTTGGGCTCC TTTTTCTCCC TCTGGATCAA AGTAGGCAGG ACCATGGGAC CAGGTCTTGG AGCTGAGCCT CTCACCTGTA CTCTTCCGAA AAATCCTCTT CCTCTGAGGC TGGATCCTAG CCTTATCCTC TGATCTCCAT GGCTTCCTCC TCCCTCCTGC CGACTCCTGG GTTGAGCTGT TGCCTCAGTC CCCCAACAGA TGCTTTTCTG TCTCTGCCTC CCTCACCCTG AGCCCCTTCC TTGCTCTGCA CCCCCATATG GTCATAGCCC AGATCAGCTC CTAACCCTTA TCACCAGCTC CCTCTTCTGT GGGTGACCCA GGTCCTTGTT TGCTGTTGAT TTCTTTCCAG AGGGGTTGAG CAGGGATCCT GGTTTCAATG ACGGTTGGAA ATAGAAATTT CCAGAGAAGA GAGTATTGGG TAGATATTTT TTCTGAATAC AAAGTGATGT GTTTAAATAC TGCAATTAAA GTGATACTGA AACAC-3' (FRAG. No: ) (SEQ. ID NO:2466)

5'-AGGATGATGG TGATGGGGAA CTAAATGGGG AAATATGGAA GGTCACAGGA AAAGTTAACA CAAGTTAGCA AAAAGTTAAC ATAACACAAA AAGGTCTTGC AGGAAAAAAA AAAGAAAAGA AAAGAAAGAA AAAGTCTCCA AGAATGGTTT GGACAGCCAA AATGAATACT TATAGTCACG TATACCTGCT CACTCCTGAC GCTTCACTCA CACACAGCAC AGGATCTGGT GAGGCTATCA CTAAATGTGC CACATTGTGG TTAAGTTTTA CCTGATTAAC GAAATGCTCA CACTTCTAAA CTGAGGTCCT TACAGTAGAT TCCTTTTGCA AGATTGTTAC TGGCTTACAA CTTAAAAATA AAGGAAAATC ACAAGGAAAG AAAAGTGGGG AAAAAATCGG AGGAAACTTG CCCCTGCCCT GGCCACCGGC AAGGCTGCCA CAAAGGGGTT AAAAGTTAAG TGGAAGTGGA GCTTGAAGAA GTGGGATGGG GCCTCTCCAG GAAAGCTGAA CGAGGCATCT GGAGCCCGAA CAAACCTCCA CCTTTTTTGG CCTCGACGGC GGCAACCCAG CCTCCCTCCT AACGCCCTCC GCCTTTGGGA CCAACCAGGG GAGCTCAAGT TAGTAGCAGC CAAGGAGAGG CGCTGCCTTG CCAAGACTAA AAAGGGAGGG GAGAAGAGAG GAAAAAAGCA AGAATCCCCC ACCCCTCTCC CGGGCGGAGG GGGCGGGAAG AGCGCGTCCT GGCCAAGCCG AGTAGTGTCT TCCACTCGGT GCGTCTCTCT AGGAGCCGCG CGGGAAGGAT GCTGGTCCGC AGGGGCGCGC GCGCAGGGCC CAGGATGCCG CGGGGCTGGA CCGCGCTTTG CTTGCTGAGT TTGCTGC-3' (FRAG. NO: (SEQ. ID NO:2464)

5'-CCTTTTTTGG CCTCGACGGC GGCAACCCAG CCTCCCTCCT AACGCCCTCC GCCTTTGGGA CCAACCAGGG GAGCTCAAGT TAGTAGCAGC CAAGGAGAGG CGCTGCCTTG CCAAGACTAA AAAGGGAGGG GAGAAGAGAG GAAAAAAGCA AGAATCCCCC ACCCCTCTCC CGGGCGGAGG GGGCGGGAAG AGCGCGTCCT GGCCAAGCCG AGTAGTGTCT TCCACTCGGT EPI-109 248

GCGTCTCTCT AGGAGCCGCG CGGGAAGGAT GCTGGTCCGC AGGGGCGCGC GCGAGGGCCC AGGATGCCGC GGGGCTGGAC CGCGCTTTGC TTGCTGAGTT TGCTGCCTTC TGGGTTCATG AGTCTTGACA ACAACGGTAC TGCTACCCCA GAGTTACCTA CCCAGGGAAC ATTTTCAAAT GTTTCTACAA ATGTATCCTA CCAAGAAACT ACAACACCTA GTACCCTTGG AAGTACCAGC CTGCACCCTG TGTCTCAACA TGGCAATGAG GCCACAACAA ACATCACAGA AACGACAGTC AAATTCACAT CTACCTCTGT GATAACCTCA GTTTATGGAA ACACAAACTC TTCTGTCCAG TCACAGACCT CTGTAATCAG CACAGTGTTC ACCACCCCAG CCAACGTTTC AACTCCAGAG ACAACCTTGA AGCCTAGCCT GTCACCTGGA AATGTTTCAG ACCTTTCAAC CACTAGCACT AGCCTTGCAA CATCTCCCAC TAAACCCTAT ACATCATCTT CTCCTATCCT AAGTGACATC AAGGCAGAAA TCAAATGTTC AGGCATCAGA GAAGTGAAAT TGACTCAGGG CATCTGCCTG GAGCAAAATA AGACCTCCAG CTGTGCGGAG TTTAAGAAGG ACAGGGGAGA GGGCCTGGCC CGAGTGCTGT GTGGGGAGGA GCAGGCTGAT GCTGATGCTG GGGCCCAGGT ATGCTCCCTG CTCCTTGCCC AGTCTGAGGT GAGGCCTCAG TGTCTACTGC TGGTCTTGGC CAACAGAACA GAAATTTCCA GCAAACTCCA ACTTATGAAA AAGCACCAAT CTGACCTGAA AAAGCTGGGG ATCCTAGATT TCACTGAGCA AGATGTTGCA AGCCACCAGA GCTATTCCCA AAAGACCCTG ATTGCACTGG TCACCTCGGG AGCCCTGCTG GCTGTCTTGG GCATCACTGG CTATTTCCTG ATGAATCGCC GCAGCTGGAG CCCCACAGGA GAAAGGCTGG GCGAAGACCC TTATTACACG GAAAACGGTG GAGGCCAGGG CTATAGCTCA GGACCTGGGA CCTCCCCTGA GGCTCAGGGA AAGGCCAGTG TGAACCGAGG GGCTCAGAAA AACGGGACCG GCCAGGCCAC CTCCAGAAAC GGCCATTCAG CAAGACAACA CGTGGTGGCT GATACCGAAT TGTGACTCGG CTAGGTGGGG CAAGGCTGGG CAGTGTCCGA GAGAGCACCC CTCTCTGCAT CTGACCACGT GCTACCCCCA TGCTGGAGGT GACATCTCTT ACGCCCAACC CTTCCCCACT GCACACACCT CAGAGGCTGT TCTTGGGGCC CTACACCTTG AGGAGGGGGC AGGTAAACTC CTGTCCTTTA CACATTCGGC TCCCTGGAGC CAGACTCTGG TCTTCTTTGG GTAAACGTGT GACGGGGGAA AGCCAAGGTC TGGAGAAGCT CCCAGGAACA ATCGATGGCC TTGCAGCACT CACACAGGAC CCCCTTCCCC TACCCCCTCC TCTCTGCCGC AATACAGGAA CCCCCAGGGG AAAGATGAGC TTTTCTAGGC TACAATTTTC TCCCAGGAAG CTTTGATTTT TACCGTTTCT TCCCTGTATT TTCTTTCTCT ACTTTGAGGA AACCAAAGTA ACCTTTTGCA CCTGCTCTCT TGTAATGATA TAGCCAGAAA AACGTGTTGC CTTGAACCAC TTCCCTCATC TCTCCTCCAA GACACTGTGG ACTTGGTCAC CAGCTCCTCC CTTGTTCTCT AAGTTCCACT GAGCTCCATG TGCCCCCTCT ACCATTTGCA GAGTCCTGCA CAGTTTTCTG GCTGGAGCCT AGAACAGGCC TCCCAAGTTT TAGGACAAAC AGCTCAGTTC TAGTCTCTCT GGGGCCACAC AGAAACTCTT TTTGGGCTCC TTTTTCTCCC TCTGGATCAA AGTAGGCAGG ACCATGGGAC CAGGTCTTGG AGCTGAGCCT CTCACCTGTA CTCTTCCGAA AAATCCTCTT CCTCTGAGGC TGGATCCTAG CCTTATCCTC TGATCTCCAT GGCTTCCTCC TCCCTCCTGC CGACTCCTGG GTTGAGCTGT TGCCTCAGTC CCCCAACAGA TGCTTTTCTG TCTCTGCCTC CCTCACCCTG AGCCCCTTCC TTGCTCTGCA CCCCCATATG GTCATAGCCC AGATCAGCTC CTAACCCTTA TCACCAGCTG CCTCTTCTGT GGGTGACCCA GGTCCTTGTT TGCTGTTGAT TTCTTTCCAG AGGGGTTGAG CAGGGATCCT GGTTTCAATG ACGGTTGGAA ATAGAAATTT CCAGAGAAGA GAGTATTGGG TAGATATTTT TTCTGAATAC AAAGTGATGT GTTTAAATAC TGCAATTAAA GTGATACTGA AACAC-3' (FRAG. No: ) (SEQ. ID NO:2465)

Eotaxin Antisense Nucleic Acids and Oligonucleotide Fragments

S'-GCAΠTΠTC AAGTTTTATG ATTTATTTAA CTTGTGGAAC AAAAATAAAC CAGAAACCAC CACCTCTCAC GCCAAAGCTC ACACCTTCAG CCTCCAACAT GAAGGTCTCC GCAGCACTTC TGTGGCTGCT GCTCATAGCA GCTGCCTTCA GCCCCCAGGG GCTCGCTGGG CCAGCTTCTG TCCCAACCAC CTGCTGCTTT AACCTGGCCA ATAGGAAGAT ACCCCTTCAG CGACTAGAGA GCTACAGGAG AATCACCAGT GGCAAATGTC CCCAGAAAGC TGTGATCTTC AAGACCAAAC TGGCCAAGGA TATCTGTGCC GACCCCAAGA AGAAGTGGGT GCAGGATTCC ATGAAGTATC TGGACCAAAA ATCTCCAACT CCAAAGCCAT AAATAATCAC CATTTTTGAA ACCAAACCAG AGCCTGAGTG TTGCCTAATT TGTTTTCCCT TCTTACAATG CATTCTGAGG TAACCTCATT ATCAGTCCAA AGGGCATGGG TTTTATTATA TATATATATA TTTTTTTTTT AAAAAAAAAC GTATTGCATT TAATTTATTG AGGCTTTAAA ACTTATCCTC CATGAATATC AGTTATTTTT AAACTGTAAA GCTTTGTGCA GATTCTTTAC CCCCTGGGAG CCCCAATTCG ATCCCCTGTC ACGTGTGGGC AATGTTCCCC CTCTCCTCTC TTCCTCCCTG GAATCTTGTA AAGGTCCTGG CAAAGATGAT CAGTATGAAA ATGTCATTGT TCTTGTGAAC CCAAAGTGTG ACTCATTAAA TGGAAGTAAA TGTTGTTTTA GGAATAC ATGAAGGTCT CCGCAGCACT TCTGTGGCTG CTGCTCATAG CAGCTGCCTT CAGCCCCCAG GGGCTCGCTG GGCCAGCTTC TGTCCCAACC ACCTGCTGCT TTAACCTGGC CAATAGGAAG ATACCCCTTC AGCGACTAGA GAGCTACAGG AGAATCACCA GTGGCAAATG TCCCCAGAAA GCTGTGATCT TCAAGACCAA ACTGGCCAAG GATATCTGTG CCGACCCCAA GAAGAAGTGG GTGCAGGATT CCATGAAGTA TCTGGACCAA AAATCTCCAA CTCCAAAGCC ATAA CCACATATTC CCCTCCTTTT CCAAGGCAAG ATCCAGATGG ATTAAAAAAT GTACCAAGTC CCTCCTACTA GCTTGCCTCT CTTCTGTTCT GCTTGACTTC CTAGGATCTG GAATCTGGTC AGCAATCAGG AATCCCTTCA TCGTGACCCC CGCATGGGCA AAGGCTTCCC TGGAATCTCC CACACTGTCT GCTCCCTATA AAAGGCAGGC AGATGGGCCA GAGGAGCAGA GAGGCTGAGA CCAACCCAGA AACCACCACC TCTCACGCCA AAGCTCACAC CTTCAGCCTC CAACATGAAG GTCTCCGCAG CACTTCTGTG GCTGCTGCTC ATAGCAGCTG CCTTCAGCCC CCAGGGGCTC GCTGGGCCAG GTAAGCCCCC CAACTCCTTA CAGGAAAGGT AAGGTAACCA CCTCCAGGCT ACTAGGTCAG CAAGAATCTT TACAGACTCA CTGCAAATTC TCCATTTGAA AAATAGGGAA ACAGGTTTTG TGGGTGGACA AGAAATGCCT CAACCGTCAC ATCCAGTCAC TGGAAGAGCC AGAACTAGAA AGCTCCCGAG TCTTTTCCCC ACATTCAAGA GGGCCGCTGG GTGCATCCTT ACCCAGCTAT CCTTACAGTG TTTGGGAATG GGGAATGGCT CTGTCTTACT GTGGGCATGG TGGGCATTTT TGGCAGTGGG AGAGAAGGAA AATCTGTTGA TTAGAAGCTC AGTATGTTAA TTCGACTCCA GGACAGCTTT CAGAGACAGT GGCTAAGAGA AGAACGAGGT CCCAGGGGAT CTCTTGAGGT GACTTATTTT GACACTCTTT GGGAAAGTTA TCTAGGAGAT TTGTTCCATA ACTCATTTTC CCATACTCTG GTGACAAATT TACTGAGTGT ATCGGTCCCA CTGAGCCAGT GCATAGCATG GTAACAAACA GTTCTAAATT ATCAATGACT TAACAGAATT AACTAAATTA ACAAAAGTTA CTTTCTCACT TGTACTAAAT ATCTATAATG TATGGGCTCA GGCTTCTGCA TTTTATACTC AGGATTCTAG ACTGATGGAG AAGTTGCCAT GTGGGGGAAC ATTGATGGAT ACTGTGATAA AGCAGAAGAA AGCTCTCAGG AGTCTTGCAT AGGCAATGCA CTGTGGCTCA AAAATGACAC CCATCACTTT GTCTCCTTCT TTATTGATCA AAACTAATTA ATGCCTCCAA CCAAACAAAA GTGGCCAAGA AATGCAAGTC TACCTTGTGT CTCAAAACAG AGGATGGAGA ATATTTGGTG AAAATTACCA TGACCATCAC ATGGCCACGT AGGTCTTTAT AATGACAGAG CTAGCATTTG TCACATTGAC CAAGCTTTGT CCATACACTC TACAGTAATG ATGAGTCCTC AGTGCACAGG GGAGGATGCT GAAGACACAG GACAGCATCC TCCAGACACA TAAGACTTCA GAGCAGAGGG ATTCTCCCTC CACCTCTCGC AATTCCTTGC TTTCTCCTAA CTTCCTTTAC AAAGTCATGC TTGGAAATGT CTATGTATCA TCATGTGGCT CATTTTTTTC TCTGTTCATT TTTTTTCCCC AAAATTCAGC TTCTGTCCCA ACCACCTGCT GCTTTAACCT GGCCAATAGG AAGATACCCC TTCAGCGACT AGAGAGCTAC AGGAGAATCA CCAGTGGCAA ATGTCCCCAG AAAGCTGTGA TGTAAGTAAA TAAAGTTCAC CCTCCCCTAG ACAAAAAAAT AATGTCTAGG GCACAGAGTC AAGAACTGTG GGAGTCATAG ACTCTGATAG TTTGACCTCT ATGGTCCAAT TCATTAATTT TCACAAGTGA GTGTTCACTC CCAGCTCCCT GCCTGGGAGA EPI-109 249

TTGCTGTAGT CATATCAATT TCTTCAAGTC AAGAGCAAAG ATGGTTTTAC TGGGCCTTTA AGAGCAGCAA CTAACCCAAG AGTCTCATCC TTCCTCCTCT CCGTAGCAAC CCTTTGTCCA GGGGCAGATG GTCCTTAAAT ATTTAGGGTC AAATGGGCAG AATTTTCAAA AACAATCCTT CCAATTGCAT CCTGATTCTC CCCACAGCTT CAAGACCAAA CTGGCCAAGG ATATCTGTGC CGACCCCAAG AAGAAGTGGG TGCAGGATTC CATGAAGTAT CTGGACCAAA AATCTCCAAC TCCAAAGCCA TAAATAATCA CCATTTTTGA AACCAAACCA GAGCCTGAGT GTTGCCTAAT TTGTTTTCCC TTCTTACAAT GCATTCTGAG GTAACCTCAT TATCAGTCCA AAGGGCATGG GTTTTATTAT ATATATATAT ATATATTTTT TTTTAAAAAA AAACGTATTC CATTTAATTT ATTGAGGCTT TAAAACTTAT CCTCCATGAA TATCAGTTAT TTTTAAACTG TAAAGCTTTG TGCAGATTCT TTACCCCCTG GGAGCCCGAA TTCGATCCCC TGTCACGTGT GGGCAATGTT CCCCCTCTCC TCTCTTCCTC CCTGGAATCT TGTAAAGGTC CTGGCAAAGA TGATCAGTAT GAAAATGTCA TTGTTCTTGT GAACCCAAAG TGTGACTCAT TAAATGGAAG TAATGTTGTT TTAGGAATAC ATAAAGTATG TGCATATTTT ATTATAGTCA CTAGTTGTAA TTTTTTTGTG GGAAATCCAC ACTGAGCTGA GGGGG-3- ( FRAG . NO : _) ( SEQ . ID NO : 2494 )

5'-GCATTTTTTC AAGTTTTATG ATTTATTTAA CTTGTGGAAC AAAAATAAAC CAGAAACCAC CACCTCTCAC GCCAAAGCTC ACACCTTCAG CCTCCAACAT GAAGGTCTCC GCAGCACTTC TGTGGCTGCT GCTCATAGCA GCTGCCTTCA GCCCCCAGGG GCTCGCTGGG CCAGCTTCTG TCCCAACCAC CTGCTGCTTT AACCTGGCCA ATAGGAAGAT ACCCCTTCAG CGACTAGAGA GCTACAGGAG AATCACCAGT GGCAAATGTC CCCAGAAAGC TGTGATCTTC AAGACCAAAC TGGCCAAGGA TATCTGTGCC GACCCCAAGA AGAAGTGGGT GCAGGATTCC ATGAAGTATC TGGACCAAAA ATCTCCAACT CCAAAGCCAT AAATAATCAC CATTTTTGAA ACCAAACCAG AGCCTGAGTG TTGCCTAATT TGTTTTCCCT TCTTACAATG CATTCTGAGG TAACCTCATT ATCAGTCCAA AGGGCATGGG TTTTATTATA TATATATATA TTTTTTTTTT AAAAAAAAAC GTATTGCATT TAATTTATTG AGGCTTTAAA ACTTATCCTC CATGAATATC AGTTATTTTT AAACTGTAAA GCTTTGTGCA GATTCTTTAC CCCCTGGGAG CCCCAATTCG ATCCCCTGTC ACGTGTGGGC AATGTTCCCC CTCTCCTCTC TTCCTCCCTG GAATCTTGTA AAGGTCCTGG CAAAGATGAT CAGTATGAAA ATGTCATTGT TCTTGTGAAC CCAAAGTGTG ACTCATTAAA TGGAAGTAAA TGTTGTTTTA GGAATAC-3' (FRAG.NO:J(SEQ. ID NO:2491)

5'-ATGAAGGTCT CCGCAGCACT TCTGTGGCTG CTGCTCATAG CAGCTGCCTT CAGCCCCCAG GGGCTCGCTG GGCCAGCTTC TGTCCCAACC ACCTGCTGCT TTAACCTGGC CAATAGGAAG ATACCCCTTC AGCGACTAGA GAGCTACAGG AGAATCACCA GTGGCAAATG TCCCCAGAAA GCTGTGATCT TCAAGACCAA ACTGGCCAAG GATATCTGTG CCGACCCCAA GAAGAAGTGG GTGCAGGATT CCATGAAGTA TCTGGACCAA AAATCTCCAA CTCCAAAGCC ATAA-3' (FRAG. NO:_)(SEQ. ID NO:2492) 5'-CCACATATTC CCCTCCTTTT CCAAGGCAAG ATCCAGATGG ATTAAAAAAT GTACCAAGTC CCTCCTACTA GCTTGCCTCT CTTCTGTTCT GCTTGACTTC CTAGGATCTG GAATCTGGTC AGCAATCAGG AATCCCTTCA TCGTGACCCC CGCATGGGCA AAGGCTTCCC TGGAATCTCC CACACTGTCT GCTCCCTATA AAAGGCAGGC AGATGGGCCA GAGGAGCAGA GAGGCTGAGA CCAACCCAGA AACCACCACC TCTCACGCCA AAGCTCACAC CTTCAGCCTC CAACATGAAG GTCTCCGCAG CACTTCTGTG GCTGCTGCTC ATAGCAGCTG CCTTCAGCCC CCAGGGGCTC GCTGGGCCAG GTAAGCCCCC CAACTCCTTA CAGGAAAGGT AAGGTAACCA CCTCCAGGCT ACTAGGTCAG CAAGAATCTT TACAGACTCA CTGCAAATTC TCCATTTGAA AAATAGGGAA ACAGGTTTTG TGGGTGGACA AGAAATGCCT CAACCGTCAC ATCCAGTCAC TGGAAGAGCC AGAACTAGAA AGCTCCCGAG TCTTTTCCCC ACATTCAAGA GGGCCGCTGG GTGCATCCTT ACCCAGCTAT CCTTACAGTG TTTGGGAATG GGGAATGGCT CTGTCTTACT GTGGGCATGG TGGGCATTTT TGGCAGTGGG AGAGAAGGAA AATCTGTTGA TTAGAAGCTC AGTATGTTAA TTCGACTCCA GGACAGCTTT CAGAGACAGT GGCTAAGAGA AGAACGAGGT CCCAGGGGAT CTCTTGAGGT GACTTATTTT GACACTCTTT GGGAAAGTTA TCTAGGAGAT TTGTTCCATA ACTCATTTTC CCATACTCTG GTGACAAATT TACTGAGTGT ATCGGTCCCA CTGAGCCAGT GCATAGCATG GTAACAAACA GTTCTAAATT ATCAATGACT TAACAGAATT AACTAAATTA ACAAAAGTTA CTTTCTCACT TGTACTAAAT ATCTATAATG TATGGGCTCA GGCTTCTGCA TTTTATACTC AGGATTCTAG ACTGATGGAG AAGTTGCCAT GTGGGGGAAC ATTGATGGAT ACTGTGATAA AGCAGAAGAA AGCTCTCAGG AGTCTTGCAT AGGCAATGCA CTGTGGCTCA AAAATGACAC CCATCACTTT GTCTCCTTCT TTATTGATCA AAACTAATTA ATGCCTCCAA CCAAACAAAA GTGGCCAAGA AATGCAAGTC TACCTTGTGT CTCAAAACAG AGGATGGAGA ATATTTGGTG AAAATTACCA TGACCATCAC ATGGCCACGT AGGTCTTTAT AATGACAGAG CTAGCATTTG TCACATTGAC CAAGCTTTGT CCATACACTC TACAGTAATG ATGAGTCCTC AGTGCACAGG GGAGGATGCT GAAGACACAG GACAGCATCC TCCAGACACA TAAGACTTCA GAGCAGAGGG ATTCTCCCTC CACCTCTCGC AATTCCTTGC TTTCTCCTAA CTTCCTTTAC AAAGTCATGC TTGGAAATGT CTATGTATCA TCATGTGGCT CATTTTTTTC TCTGTTCATT TTTTTTCCCC AAAATTCAGC TTCTGTCCCA ACCACCTGCT GCTTTAACCT GGCCAATAGG AAGATACCCC TTCAGCGACT AGAGAGCTAC AGGAGAATCA CCAGTGGCAA ATGTCCCCAG AAAGCTGTGA TGTAAGTAAA TAAAGTTCAC CCTCCCCTAG ACAAAAAAAT AATGTCTAGG GCACAGAGTC AAGAACTGTG GGAGTCATAG ACTCTGATAG TTTGACCTCT ATGGTCCAAT TCATTAATTT TCACAAGTGA GTGTTCACTC CCAGCTCCCT GCCTGGGAGA TTGCTGTAGT CATATCAATT TCTTCAAGTC AAGAGCAAAG ATGGTTTTAC TGGGCCTTTA AGAGCAGCAA CTAACCCAAG AGTCTCATCC TTCCTCCTCT CCGTAGCAAC CCTTTGTCCA GGGGCAGATG GTCCTTAAAT ATTTAGGGTC AAATGGGCAG AATTTTCAAA AACAATCCTT CCAATTGCAT CCTGATTCTC CCCACAGCTT CAAGACCAAA CTGGCCAAGG ATATCTGTGC CGACCCCAAG AAGAAGTGGG TGCAGGATTC CATGAAGTAT CTGGACCAAA AATCTCCAAC TCCAAAGCCA TAAATAATCA CCATTTTTGA AACCAAACCA GAGCCTGAGT GTTGCCTAAT TTGTTTTCCC TTCTTACAAT GCATTCTGAG GTAACCTCAT TATCAGTCCA AAGGGCATGG GTTTTATTAT ATATATATAT ATATATTTTT TTTTAAAAAA AAACGTATTG CATTTAATTT ATTGAGGCTT TAAAACTTAT CCTCCATGAA TATCAGTTAT TTTTAAACTG TAAAGCTTTG TGCAGATTCT TTACCCCCTG GGAGCCCCAA TTCGATCCCC TGTCACGTGT GGGCAATGTT CCCCCTCTCC TCTCTTCCTC CCTGGAATCT TGTAAAGGTC CTGGCAAAGA TGATCAGTAT GAAAATGTCA TTGTTCTTGT GAACCCAAAG TGTGACTCAT TAAATGGAAG TAATGTTGTT TTAGGAATAC ATAAAGTATG TGCATATTTT ATTATAGTCA CTAGTTGTAA TTTTTTTGTG GGAAATCCAC ACTGAGCTGA GGGGG-3' (FRAG. NO:_)(SEQ. ID NO:2493) FK-506 Binding Protein Nucleic Acids and Oligonucleotide Fragments

5'- GCCAGGTCGC TGTTGGTCCA CGCCGCCCGT CGCGCCGCCC GCCCGCTCAG CGTCCGCCGC CGCCATGGGA GGCCGGAGCC GAGCCGGGGT CGGGCAGCAG CAGGGACCCC CCAGAGGCGG GGCCTGTGGG ACCGCTATGG GCGTGGAGAT CGAGACCATC TCCCCCGGAG ACGGAAGGAC ATTCCCCAAG AAGGGCCAAA CGTGTGTGGT GCACTACACA GGAATGCTCC AAAATGGGAA GAAGTTTGAT TCATCCAGAG ACAGAAACAA ACCTTTCAAG TTCAGAATTG GCAAACAGGA AGTCATCAAA GGTTTTGAAG AGGGTGCAGC CCAGATGAGC TTGGGGCAGA GGGCGAAGCT GACCTGCACC CCTGATGTGG CATATGGAGC CACGGGCCAC CCCGGTGTCA TCCCTCCCAA TGCCACCCTC ATCTTTGACG TGGAGCTGCT CAACTTAGAG TGAAGGCAGG AAGGAACTCA AGGTGGCTGG AGATGGCTGC TGCTCACCCT CCTAGCCTGC TCTGCCACTG GGACGGCTCC TGCTTTTGGG GCTCTTGATC AGTGTGCTAA CCTCACTGCC TCATGGCATC ATCCATTCTC TCTGCCCAAG TTGCTCTGTA TGTGTTCGTC EPI-109 250

AGTGTTCATG CGAATTCTTG CTTGAGGAAA CTTCGGTTGC AGATTGAAGC ATTTCAGGTT GTGCATTTTC TGTGATGCAT GTAGTAGCCT TTCCTGATGA CAGAACACAG ATCTCTTGTT CGCACAATCT ACACTGCCTT ACCTTCACTT AAACCACACA CACAAGGTGC TCAGACATGA AATGTACATG GCGTACCGTA CACAGAGGGA CTTGAGCCAG TTACCTTTGC TGTCACTTTC TCTCTTATAA ATTCTGTTAG CTGCTCACTT AAACAATGTC CTCTTTGAGA AAATGTAAAA TAAAGGCTCT GTGCTTGACA GAATTCGGGC CGCCGCCAGG TCGCTGTTGG TCCACGCCGC CCGTCGCGCC GCCCGCCCGC TCAGCGTCCG CCGCCGCCAT GGGAGTGCAG GTGGAAACCA TCTCCCCAGG AGACGGGCGC ACCTTCCCCA AGCGCGGCCA GACCTGCGTG GTGCACTACA CCGGGATGCT TGAAGATGGA AAGAAATTTG ATTCCTCCCG GGACAGAAAC AAGCCCTTTA AGTTTATGCT AGGCAAGCAG GAGGTGATCC GAGGCTGGGA AGAAGGGGTT GCCCAGATGA GTGTGGGTCA GAGAGCCAAA CTGACTATAT CTCCAGATTA TGCCTATGGT GCCACTGGGC ACCCAGGCAT CATCCCACCA CATGCCACTC TCGTCTTCGA TGTGGAGCTT CTAAAACTGG AATGACAGGA ATGGCCTCCT CCCTTAGCTC CCTGTTCTTG GATCTGCCAT GGAGGGATCT GGTGCCTCCA GACATGTGCA CATGAGTCCA TATGGAGCTT TTCCTGATGT TCCACTCCAC TTTGTATAGA CATCTGCCCT GACTGAATGT GTTCTGTCAC TCAGCTTTGC TTCCGACACC TCTGTTTCCT CTTCCCCTTT CTCCTCGTAT GTGTGTTTAC CTAAACTATA TGCCATAAAC CTCAAGTTAT TCATTTTATT TTGTTTTCAT TTTGGGGTGA AGATTCAGTT TCAGTCTTTT GGATATAGGT TTCCAATTAA GTACATGGTC AAGTATTAAC AGCACAAGTG GTAGGTTAAC ATTAGAATAG GAATTGGTGT TGGGGGGGGG GTTTGCAAGA ATATTTTATT TTAATTTTTT GGATGAAATT TTTATCTATT ATATATTAAA CATTCTTGCT GCTGCGCTGC AAAGCCATAG CAGATTTGAG GCGCTGTTGA GGACTGAATT ACTCTCCAAG TTGAGAGATG TCTTTGGGTT AAATTAAAAG CCCTACCTAA AACTGAGGTG GGGATGGGGA GAGCCTTTGC CTCCACCATT CCCACCCACC CTCCCCTTAA ACCCTCTGCC TTTGAAAGTA GATCATGTTC ACTGCAATGC TGGACACTAC AGGTATCTGT CCCTGGGCCA GCAGGGACCT CTGAAGCCTT CTTTGTGGCC TTTTTTTTTT TTCATCCTGT GGTTTTTCTA ATGGACTTTC AGGAATTTTG TAATCTCATA ACTTTCCAAG CTCCACCACT TCCTAAATCT TAAGAACTTT AATTGACAGT TTCAATTGAA GGTGCTGTTT GTAGACTTAA CACCCAGTGA AAGCCCAGCC ATCATGACAA ATCCTTGAAT GTTCTCTTAA GAAAATGATG CTGGTCATCG CAGCTTCAGC ATCTCCTGTT TTTTGATGCT TGGCTCCCTC TGCTGATCTC AGTTTCCTGG CTTTTCCTCC CTCAGCCCCT TCTCACCCCT TTGCTGTCCT GTGTAGTGAT TTGGTGAGAA ATCGTTGCTG CACCCTTCCC CCAGCACCAT TTATGAGTCT CAAGTTTTAT TATTGCAATA AAAGTGCTTT ATGCCCGAAT TC GCCGCCGCCA TGGGAGTGCA GGTGGAAACC ATCTCCCCAG GAGACGGGCG CACCTTCCCC

AAGCGCGGCC AGACCTGCGT GGTGCACTAC ACCGGGATGC TTGAAGATGG AAAGAAATTT GATTCCTCCC GGGACAGAAA CAAGCCCTTT AAGTTTATGC TAGGCAAGCA GGAGGTGATC CGAGGCTGGG AAGAAGGGGT TGCCCAGATG AGTGTGGGTC AGAGAGCCAA ACTGACTATA TCTCCAGATT ATGCCTATGG TGCCACTGGG CACCCAGGCA TCATCCCACC ACATGCCACT CTCGTCTTCG ATGTGGAGCT TCTAAAACTG GAATGACAGG AATGGCCTCC TCCCTTAGCT CCCTGTTCTT GGATCTGCCR TGGAGGGATC TGGTGCCTCC AGACATGTGC ACATGARTCC ATATGGAGCT TTTCCTGATG TTCCACTCCA CTTTGTATAG ACATCTGCCC TGACTGAATG TGTTCTGTCA CTCAGCTTTG CTTCCGACAC CTCTGTTTCC TCTTCCCCTT TCTCCTCGTA TGTGTGTTTA CCTAAACTAT ATGCCATAAA CCTCAAGTTA TTCA-3' (FRAG NO _)(SEQ ID NO 2499)

5'-GCCAGGTCGC TGTTGGTCCA CGCCGCCCGT CGCGCCGCCC GCCCGCTCAG CGTCCGCCGC CGCCATGGGA-3' (FRAG. No:J(SEQ. ID NO: 2495)

5'-GGCCGGAGCC GAGCCGGGGT CGGGCAGCAG CAGGGACCCC CCAGAGGCGG GGCCTGTGGG ACCGCTATGG GCGTGGAGAT CGAGACCATC TCCCCCGGAG ACGGAAGGAC ATTCCCCAAG AAGGGCCAAA CGTGTGTGGT GCACTACACA GGAATGCTCC AAAATGGGAA GAAGTTTGAT TCATCCAGAG ACAGAAACAA ACCTTTCAAG TTCAGAATTG GCAAACAGGA AGTCATCAAA GGTTTTGAAG AGGGTGCAGC CCAGATGAGC TTGGGGCAGA GGGCGAAGCT GACCTGCACC CCTGATGTGG CATATGGAGC CACGGGCCAC CCCGGTGTCA TCCCTCCCAA TGCCACCCTC ATCTTTGACG TGGAGCTGCT CAACTTAGAG TGAAGGCAGG AAGGAACTCA AGGTGGCTGG AGATGGCTGC TCCTCACCCT CCTAGCCTGC TCTGCCACTG GGACGGCTCC TGCTTTTGGG GCTCTTGATC AGTGTGCTAA CCTCACTGCC TCATGGCATC ATCCATTCTC TCTGCCCAAG TTGCTCTGTA TGTGTTCGTC AGTGTTCATG CGAATTCTTG CTTGAGGAAA CTTCGGTTGC AGATTGAAGC ATTTCAGGTT GTGCATTTTC TGTGATGCAT GTAGTAGCCT TTCCTGATGA CAGAACACAG ATCTCTTGTT CGCACAATCT ACACTGCCTT ACCTTCACTT AAACCACACA CACAAGGTGC TCAGACATGA AATGTACATG GCGTACCGTA CACAGAGGGA CTTGAGCCAG TTACCTTTGC TGTCACTTTC TCTCTTATAA ATTCTGTTAG CTGCTCACTT AAACAATGTC CTCTTTGAGA AAATGTAAAA TAAAGGCTCT GTGCTTGACA- 3 ' ( FRAG . Nθ : _) ( SEQ . ID NO : 24 96 )

5'-GAATTCGGGC CGCCGCCAGG TCGCTGTTGG TCCACGCCGC CCGTCGCGCC GCCCGCCCGC TCAGCGTCCG CCGCCGCCAT GGGAGTGCAG GTGGAAACCA TCTCCCCAGG AGACGGGCGC ACCTTCCCCA AGCGCGGCCA GACCTGCGTG GTGCACTACA CCGGGATGCT TGAAGATGGA AAGAAATTTG ATTCCTCCCG GGACAGAAAC AAGCCCTTTA AGTTTATGCT AGGCAAGCAG GAGGTGATCC GAGGCTGGGA AGAAGGGGTT GCCCAGATGA GTGTGGGTCA GAGAGCCAAA CTGACTATAT CTCCAGATTA TGCCTATGGT GCCACTGGGC ACCCAGGCAT CATCCCACCA CATGCCACTC TCGTCTTCGA TGTGGAGCTT CTAAAACTGG AATGACAGGA ATGGCCTCCT CCCTTAGCTC CCTGTTCTTG GATCTGCCAT GGAGGGATCT GGTGCCTCCA GACATGTGCA CATGAGTCCA TATGGAGCTT TTCCTGATGT TCCACTCCAC TTTGTATAGA CATCTGCCCT GACTGAATGT GTTCTGTCAC TCAGCTTTGC TTCCGACACC TCTGTTTCCT CTTCCCCTTT CTCCTCGTAT GTGTGTTTAC CTAAACTATA TGCCATAAAC CTCAAGTTAT TCATTTTATT TTGTTTTCAT TTTGGGGTGA AGATTCAGTT TCAGTCTTTT GGATATAGGT TTCCAATTAA GTACATGGTC AAGTATTAAC AGCACAAGTG GTAGGTTAAC ATTAGAATAG GAATTGGTGT TGGGGGGGGG GTTTGCAAGA ATATTTTATT TTAATTTTTT GGATGAAATT TTTATCTATT ATATATTAAA CATTCTTGCT GCTGCGCTGC AAAGCCATAG CAGATTTGAG GCGCTGTTGA GGACTGAATT ACTCTCCAAG TTGAGAGATG TCTTTGGGTT AAATTAAAAG CCCTACCTAA AACTGAGGTG GGGATGGGGA GAGCCTTTGC CTCCACCATT CCCACCCACC CTCCCCTTAA ACCCTCTGCC TTTGAAAGTA GATCATGTTC ACTGCAATGC TGGACACTAC AGGTATCTGT CCCTGGGCCA GCAGGGACCT CTGAAGCCTT CTTTGTGGCC TTTTTTTTTT TTCATCCTGT GGTTTTTCTA ATGGACTTTC AGGAATTTTG TAATCTCATA ACTTTCCAAG CTCCACCACT TCCTAAATCT TAAGAACTTT AATTGACAGT TTCAATTGAA GGTGCTGTTT GTAGACTTAA CACCCAGTGA AAGCCCAGCC ATCATGACAA ATCCTTGAAT GTTCTCTTAA GAAAATGATG CTGGTCATCG CAGCTTCAGC ATCTCCTGTT TTTTGATGCT TGGCTCCCTC TGCTGATCTC AGTTTCCTGG CTTTTCCTCC CTCAGCCCCT TCTCACCCCT TTGCTGTCCT GTGTAGTGAT TTGGTGAGAA ATCGTTGCTG CACCCTTCCC CCAGCACCAT TTATGAGTCT CAAGTTTTAT TATTGCAATA AAAGTGCTTT ATGCCCGAAT TC-3' (FRAG NO _)(SEQ. ID NO:2497)

5' GCCGCCGCCA TGGGAGTGCA GGTGGAAACC ATCTCCCCAG GAGACGGGCG CACCTTCCCC AAGCGCGGCC AGACCTGCGT GGTGCACTAC ACCGGGATGC TTGAAGATGG AAAGAAATTT GATTCCTCCC GGGACAGAAA CAAGCCCTTT AAGTTTATGC TAGGCAAGCA GGAGGTGATC CGAGGCTGGG AAGAAGGGGT TGCCCAGATG AGTGTGGGTC AGAGAGCCAA ACTGACTATA TCTCCAGATT ATGCCTATGG TGCCACTGGG CACCCAGGCA TCATCCCACC ACATGCCACT CTCGTCTTCG EPI-109 251

ATGTGGAGCT TCTAAAACTG GAATGACAGG AATGGCCTCC TCCCTTAGCT CCCTGTTCTT GGATCTGCCR TGGAGGGATC TGGTGCCTCC AGACATGTGC ACATGARTCC ATATGGAGCT TTTCCTGATG TTCCACTCCA CTTTGTATAG ACATCTGCCC TGACTGAATG TGTTCTGTCA CTCAGCTTTG CTTCCGACAC CTCTGTTTCC TCTTCCCCTT TCTCCTCGTA TCTGTGTTTA CCTAAACTAT ATGCCATAAA CCTCAAGTTA TTCA 3 (FRAG NO _)(SEQ ID NO 2498)

The present agents are also provided as a pharmaceutical composition compnsing an anti-sense oligonucleotide as given above in an amount effective to reduce expression of a target mRNA, by passing through a cell membrane and binding specifically with target mRNA m the cell so as to prevent its translation are another aspect of the present invention Such compositions are provided in a suitable pharmaceutically acceptable carrier, e g sterile pyrogen-free saline solution The agent of the invention may be formulated with a hydrophobic earner capable of passmg through a cell membrane, e g in a liposome, with the liposomes earned in a pharmaceutically acceptable aqueous earner The oligonucleotides may be coupled to an agent which inactivates mRNA, such as a nbozyme Such oligonucleotides may be administered to a subject in need of such treatment to inhibit the activation of A, A_2b and/or A₃ adenosine receptors The pharmaceutical formulation may also compnse chimenc molecules compnsing anti-sense oligonucleotides attached to molecules which are known to be internalized by cells These oligonucleotide conjugates utilize cellular up-take pathways to increase intracellular concentrations of the oligonucleotide Examples of molecules used in this manner are macromolecules including transfernn, asialoglycoprotein (bound to oligonucleotides via polylysine) and streptavidin, among others

The anti-sense compound may be contained m the pharmaceutical formulation within a lipid particle or vesicle, such as a liposome or microcrystal The particles may be of any suitable structure, such as unilamellar or pluπlamellar The one preferred embodiment, the anti-sense oligonucleotide is compnsed within the liposome Positively charged lipids such as N-[l-(2, 3 -dioleoyloxi) propyl] -N, N, N-tπmethylammoniumethylsulfate, or "DOTAP", are particularly preferred for such particles and vesicles However, others are also suitable The preparation of such lipid particles is well known See, e g , US Patent Nos 4,880,635 to Janoff et al , 4,906,477 to Kurono et al , 4,91 1,928 to Wallach, 4,917,951 to Wallach, 4,920,016 to Allen et al , 4,921,757 to Wheatley et al , the relevant sections of all of which are herein mcoporated in their entireties by reference The composition of the invention may be administered by any means which transports the agent to the lung(s) The present agent(s) may be administered to the lungs of a patient by any suitable means, but are preferably administered through the respiratory system as a respirable formulation, more preferably in the form of an aerosol compnsing respirable particles which, in turn, compnse the agent for respiration or inhalation by the subject The respirable particles may be m gaseous, liquid or solid form, and they may, optionally, contam other therapeutic ingredients and formulation components The particles of the present invention are preferably particles of respirable size, preferably of a size sufficiently small to pass, upon inhalation, through the mouth and larynx and into the bronchi and alveoli of the lungs In general, particles ranging from about 0 5 to 10 microns in diameter are respirable However, other sizes may also be suitable Particles of non-respirable size, of considerably larger diameter which are included in the respirable formulation tend to deposit m the throat and may be swallowed Accordingly, it is desirable to minimize the quantity of non-respirable particles in the aerosol For nasal admmistration, a particle size in the range of 10-500 m is preferred to ensure their retention m the nasal cavity Liquid pharmaceutical compositions of the agent of the invention for producing a respirable formulation, e g an aerosol may be prepared by combining the anti-sense oligo with a suitable vehicle or carrier, such as steπle pyrogen-free water and or other known pharmaceutically or vetennanly acceptable carrier Other therapeutic compounds may be included as well as other formulation ingredients as is known m the art Solid paniculate compositions compnsing respirable dry particles of, e g the micronized agent of the invention may be prepared by grinding the dry anti-sense compound with a mortar and pestle, and then passing the thus ground, e g micronized composition through a screen, e g 400 mesh screen, to break up or separate large agglomerates of particles A solid paniculate composition compnsmg the anti-sense compound may optionally also compnse a dispersant and other known agents, which serve to facilitate the formation of a mist or aerosol A suitable dispersant is lactose, which may be blended with the anti-sense compound in any suitable ratio, about 1 1 w/w Other ratios may be utilized as well, and other therapeutic and formulation agents may also be included

The dosage of the anti-sense compound administered generally vanes with the disease being treated, the condition of the subject, the particular formulation, the route of administration, the timing of administration to a subject, etc In general, it is desirable to attain intracellular concentrations of the oligonucleotide of from 0 05 to 50 M, or more particularly 02 to 5 M, although not cπtical For administration to a subject such as a human, a dosage of from about 01, preferably about 0 01, more preferably about 1 mg/Kg, to about 150, preferably about EPI-109 252

100, and still more preferably about 50 mg/Kg are typically employed Higher and lower doses may also be administered as an artisan will see suitable for specific application These amounts are preferably admmistered every 24 hrs, although other regimens are also suitable Dependmg on the solubility of the particular formulation of active compound admmistered, a daily dose may be divided among one or several unit dose administrations Admmistration of the anti-sense compounds may be earned out therapeutically, l e as a rescue treatment, prophylactically, or as a chronic mamtenance regimen

Aerosols of liquid particles compnsing the agent may be produced by any suitable means, such as with an insufflator or nebulizer See, e g , US Patent No 4,501,729 Nebulizers are commercially available devices which transform solutions or suspensions of an agent mto a therapeutic aerosol mist either by means of acceleration of a compressed gas, typically air or oxygen, e g through a narrow ventuπ orifice or by means of ultrasonic agitation Suitable formulations for use m insufflators and nebulizers comprise the present agent, the agent of this invention, in an amount of about 0 01 to about 40%, preferably less than 20% w/w in a liquid earner which is typically water or a dilute aqueous alcoholic solution, preferably made isotonic with body fluids by the addition of, for example, sodium chlonde Other earners are also suitable Optional additives include preservatives if the formulation is not prepared sterile, for example, methyl hydroxybenzoate, antioxidants, flavonng agents, volatile oils, buffenng agents and surfactants, among others

The pharmaceutical compositions provided herein comprise nucleic acιd(s) compnsmg the anti-sense ohgonucleotιde(s) descnbed above and one or more surfactants Suitable surfactants or surfactant components for enhancing the uptake of the anti-sense oligonucleotides of the invention include synthetic and natural as well as full and truncated forms of surfactant protem A, surfactant protem B, surfactant protem C, surfactant protein D and surfactant Protem E, di-saturated phosphatidylcholine (other than dipalπutoyl), dipalmitoylphosphatidylcholme, phosphatidylcholine, phosphatidylglycerol, phosphatidylinositol, phosphatidylethanolamine, phosphatidylsenne, phosphatidic acid, ubiquinones, lysophosphatidylethanolamine, lysophosphatidylcholine, palmitoyl-lysophosphatidylcho ne, dehydroepiandrosterone, dohchols, sulfatidic acid, glycerol-3-phosphate, dihydroxyacetone phosphate, glycerol, glycero-3-phosphocholιne, dihydroxyacetone, palmitate, cytidine diphosphate (CDP) diacylglycerol, CDP cholme, choline, cholme phosphate, as well as natural and artificial lamelar bodies which are the natural earner vehicles for the components of surfactant, omega-3 fatty acids, polyenic acid, polyenoic acid, lecithin, palmitmic acid, non-ionic block copolymers of ethylene or propylene oxides, polyoxypropylene, monomeric and polymenc, polyoxyethylene, monomeric and polymeric, poly (vinyl amine) with dextran and/or alkanoyl side chains, Bπj 35, Tπton X-100 and synthetic surfactants ALEC, Exosurf, Survan and Atovaquone, among others These surfactants may be useed either as single or part of a multiple component surfactant in a formulation, or as covalently bound additions to the 5' and/or 3' ends ofthe anti-sense oligonucleotides (oligos)

The composition of the invention may be admmistered by any means which transports the anti-sense nucleotide and the surfactant composition to the lung The antisense compounds disclosed herem may be admmistered to the lungs of a patient by any suitable means, but are preferably admmistered by inhalation of an aerosol comprised of respirable particles which compnse the anti-sense compound The respirable particles may be liquid or solid, and they may optionally contain other therapeutic or diagnostic mgredients as well as other typical ingredients for a particular formulation Examples of other agents are analgesics such as acetominophen, amlerdine, aspirin, buprenorphine, butabital, butorpphanol, Cholme Sahcylate, Codeme, Dezocrne, Diclofenac, Diflunisal, Dihydrocodeine, Elcatomnin, Etodolac, Fenoprofen, Hydrocodone, Hydromorphone, Ibuprofen, Ketoprofen, Ketorolac, Levorphanol, Magnesium Sahcylate, Meclofenamate, Mefenamic Acid, Mependine, Methadone, Methotnmeprazme, Morphine, Nalbuphme, Naproxen, Opium, Oxycodone, Oxymorphone, Pentazocine, Phenobarbital, Propoxyphene, Salsalate, Sodium Sahcylate, Tramadol and Narcotic analgesics m addition to those listed above See, Mosby's Physician's GenRx Anti- anxiety agents are also useful including Alprazolam, Bromazepam, Buspirone, Chlordiazepoxide, Chlormezanone, Clorazepate, Diazepam, Halazepam, Hydroxyzine, Ketaszolam, Lorazepam, Meprobamate, Oxazepam and Prazepam, among others Anti-anxiety agents associated with mental depression, such as Chlordiazepoxide, Amitnpty ne, Loxaprne Maprotiline and Perphenazine, among others Anti-inflammatory agents such as non-rheumatic Aspirin, Cholme Sahcylate, Diclofenac, Diflunisal, Etodolac, Fenoprofen, Floctafenine, Flurbiprofen, Ibuprofen, Indomethacin, Ketoprofen, Magnesium Sahcylate, Meclofenamate Mefenamic Acid, Nabumetone, Naproxen, Oxaprozm, Phenylbutazone, Piroxicam, Salsalate, Sodium Sahcylate Sulmdac Tenoxicam, Tiaprofemc Acid, Tolmetm, anti-rnflammatoπes for EPI-109 253 ocular treatment such as Diclofenac, Flurbiprofen, Indomethacin, Ketorolac, Rimexolone (generally for postoperative treatment), anti-inflammatoπes for, non-infectious nasal applications such as Beclomethaxone, Budesomde, Dexamethasone Flumsolide, Tnamcinolone, and the like Soporifics (anti-insomma/sleep inducing agents) such as those utilized for treatment of insomnia, including Alprazolam, Bromazepam, Diazepam, Diphenhydramme, Doxylamine, Estazolam, Flurazepam, Halazepam, Ketazolam, Lorazepam, Nitrazepam, Prazepam Quazepam, Temazepam, Tnazolam, Zolpidem and Sopiclone, among others Sedatives including Diphenhydramme, Hydroxyzme, Methotnmeprazme, Promethazme, Propofol, Melatonm, Tnmeprazine, and the like Sedatives and agents used for treatment of petit mal and tremors, among other conditions, such as Armtnptyline HC1, Chlordiazepoxide, Amobarbital, Secobarbital, Aprobarbital, Butabarbital, Ethchiorvynol, Glutethimide, L-Tryptophan Mephobarbital, MethoHexital Na, Midazolam Hcl, Oxazepam, Pentobarbital Na, Phenobarbital, Secobarbital Na, Thiamylal Na, and many others Agents used m the treatment of head trauma (Bram Injury/Ischemia), such as Enadolme HC1 (e g for treatment of severe head injury, orphan status, Warner Lambert), cytoprotective agents, and agents for the treatment of menopause, menopausal symptoms (treatment), e g Ergotamine, Belladonna Alkaloids and Phenobarbital, for the treatment of menopausal vasomotor symptoms, e g Clomdine, Conjugated Estrogens and Medroxyprogesterone, Estradiol, Estradiol Cypionate, Estradiol Valerate, Estrogens, conjugated Estrogens, estenfied Estrone, Estropipate, and Ethinyl Estradiol Examples of agents for treatment of pre menstrual syndrome (PMS) are Progesterone, Progestm Gonadotrophic Releasing Hormone, Oral contracep es Danazol Luprolide Acetate, Vitamin B6 Examples of agents for treatment of emotional/psychiatric treatments such as Tncychc Antidepressants including Amitnptyhne HC1 (Elavil), Amitnptyhne HC1, Perphenazine (Tnavil) and Doxepin HC1 (Sinequan) Examples of tranquilizers, anti- depressants and anti-anxiety agents are Diazepam (Va um), Lorazepam (Ativan), Alprazolam (Xanax), SSRI's (selective Ssrotonm reuptake inhibitors), Fluoxetine HC1 (Prozac), Sertaline HC1 (Zoloft), Paroxetme HC1 (Paxil), Fluvoxamine Maleate (Luvox), Venlafaxme HC1 (Effexor), Serotonin, Serotonin Agonists (Fenfluramine), and other over the counter (OTC) medications

The composition of the present invention may be admmistered into the respiratory system as a formulation including particles of respirable size, e g particles of a size sufficiently small to pass through the nose, mouth and larynx upon inhalation and through the bronchi and alveoli of the lungs In general, respirable particles range from about 5 to 10 microns m size Particles of non-respirable size which are included m the aerosol tend to deposit in the throat and be swallowed and the quantity of non-respirable particles m the aerosol is thus minimized For nasal admmistration, a particle size m the range of 10-500 m is preferred to ensure retention in the nasal cavity Aerosols or mists of solid particles compnsing the agent of the mvention may likewise be produced with any device that generates solid particulate medicament aerosols or mists Aerosol and mist generators are suitable for administering solid paniculate medicaments These devices produce respirable particles as explained above , and generate a volume of aerosol or mist containing a predetermined metered dose of a medicament at a rate suitable for human or animal administration One illustrative type of solid particulate aerosol generator is an insufflator Suitable formulations for admmistration by insufflation include finely comminuted powders which may be delivered by means of an insufflator or taken mto the nasal cavity m the manner of a snuff In the insufflator, the powder, e g a metered dose of the agent effective to carry out the treatments descnbed herem, is contamed in a capsule or a cartridge These capsules or cartridges are typically made of gelatin or plastic, and may be pierced or opened in situ, and the powder delivered by air drawn through the device upon inhalation or by means of a manually-operated pump The powder employed m the insufflator may consist either solely of the agent or of a powder blend compnsmg the agent, a suitable powder diluent, such as lactose, and an optional surfactant as well as other agents The agent typically compnses from 0 01 to 100 w/w of the formulation A second type of illustrative aerosol generator compnses a metered dose inhaler Metered dose inhalers are pressurized aerosol dispensers, typically compnsmg a suspension or solution formulation of the active ingredient m a liquified propellant Duπng use these devices discharge the formulation through a valve adapted to deliver a metered volume, typically about 10 to 150 1, although other volumes are also suitable, to produce a fine particle spray containing the active mgredient Suitable propellants include solvents such as certain chlorofluorocarbon compounds, for example, dichlorodifluoromethane, tnchlorofluoromethane, dichlorotetrafluoroethane and/or mixtures thereof The formulation may additionally compnse one or more co-solvents, for example, ethanol, surfactants, such as oleic acid or sorbitan tnoleate, antioxidants and suitable flav oring agents The aerosol, whether formed from solid or liquid particles, may be produced bv the aerosol generator at a rate of from about 10 to 150 liters per minute, more preferably from about EPI-109 254

30 to 150 liters per mmute. and most preferably about 60 liters per minute Aerosols contammg greater amounts of medicament may be admmistered more rapidly

The following examples are provided to illustrate the present invention, and should not be construed as lumtmg thereon In these examples, M means micromolar, ml means millihters, M means micrometers, mm means millimeters, cm means centimeters, EC means degrees Celsius, g means micrograms, mg means milligrams, g means grams, kg means kilograms, M means molar, and h means hours

EXAMPLES Example 1: Design and Synthesis of Anti-sense Oligonucleotides

The design of ann-sense oligonucleotides against the A, and A₃ adenosine receptors may requue the solution of the complex secondary structure of the target A, receptor mRNA and the target A₃ receptor mRNA After generatmg this structure, anti-sense nucleotide are designed which target regions of mRNA which might be construed to confer functional activity or stability to the mRNA and which optimally may overlap the initiation codon Other target sites are readily usable As a demonstration of specificity of the anti-sense effect, other oligonucleotides not totally complementary to the target mRNA, but contammg identical nucleotide compositions on a w/w basis, are included as controls m anti-sense experiments The mRNA secondary structure of the adenosme A, receptor was analyzed and used as descnbed above to design a phosphorothioate anti-sense oligonucleotide The anti-sense oligonucleotide which was synthesized was designated HAdA,AS and had the following sequence 5' -GAT GGA GGG CGG CAT GGC GGG-3' ( SEQ ID NO:l). As a control, a mismatched phosphorothioate anti-sense nucleotide designated HAdALMMl was synthesized with the following sequence 5' -GTA GCA GGC GGG GAT GGG GGC-3' (SEQ ID NO:2). Each oligonucleotide had identical base content and general sequence structure Homology searches in GENBANK (release 85 0) and EMBL (release 40 0) indicated that the anti-sense oligonucleotide was specific for the human and rabbit adenosme A, receptor genes, and that the mismatched control was not a candidate for hybndization with any known gene sequence

The secondary structure of the adenosine A₃ receptor mRNA was similarly analyzed and used as descnbed above to design two phosphorothioate anti-sense oligonucleotides The first anti-sense oligonucleotide (HAdAJASl) synthesized had the following sequence 5'-GTT GTT GGG CAT CTT GCC-3' (SEQ ID NO:3). As a control, a mismatched phosphorothioate anti-sense oligonucleotide (HAdA3MMl) was synthesized, having the following sequence 5'-GTA CTT GCG GAT CTA GGC-3' (SEQ ID NO:4). A second phosphorothioate anti-sense oligonucleotide (HAdA3AS2) was also designed and synthesized, havmg the following sequence 5'- GTG GGC CTA GCT CTC GCC-3* (SEQ ID NO:5). Its control oligonucleotide (HAdA3MM2) had the sequence 5'-GTC GGG GTA CCT GTC GGC-3' (SEQ ID NO:6). Phosphorothioate oligonucleotides were synthesized on an Applied Biosystems Model 396 Oligonucleotide Synthesizer, and punfied using NENSORB chromatography (DuPont, MD) Example 2: In Vivo Testing of Adenosine A, Receptor Anti-sense Oligos

The anti-sense oligonucleotide agamst the human A, receptor (SEQ ID NO:l) descnbed above was tested for efficacy m an m vitro model utilizing lung adenocarcmoma cells HTB-54 HTB-54 lung adenocarcinoma cells were demonstrated to express the A, adenosine receptor usmg standard northern blotting procedures and receptor probes designed and synthesized m the laboratory HTB-54 human lung adenocarcmoma cells (106/100 mm tissue culture dish) were exposed to 5 0 M HAdAlAS or HAdALMMl for 24 hours, with a fresh change of media and oligonucleotides after 12 hours of incubation Following 24 hour exposure to the oligonucleotides, cells were harvested and their RNA extracted by standard procedures A 21-mer probe correspondmg to the region of mRNA targeted by the anti-sense (and therefore havmg the same sequence as the anti-sense, but not phosphorothioated) was synthesized and used to probe northern blots of RNA prepared from HAdAlAS-treated, HAdAlMM 1 -treated and non-treated HTB-54 cells These blots showed clearly that HAdALAS but not HAdAlMM 1 effectively reduced human adenosme receptor mRNA by >50% This result showed that HAdAlAS is a good candidate for an anti- asthma drug smce it depletes intracellular mRNA for the adenosme A, receptor, which is mvolved m asthma Example 3: In Vivo Efficacy of Adenosine A, Receptor Anti-sense Oligos

A fortuitous homology between the rabbit and human DNA sequences withm the adenosine A, gene overlapping the initiation codon permitted the use of the phosphorothioate anti-sense oligonucleotides initially designed for use agamst the human adenosine A, receptor in a rabbit model Neonatal New Zealand white Pasteurella-free rabbits were immunized mtrapentoneally withm 24 hours of birth with 312 antigen umts/ml house dustmite (D farmae) extract (Berkeley Biologicals, Berkeley, CA), mixed with 10% kaolm Immunizations were EPI-109 255 repeated weekly for the first month and then biweekly for the next 2 months At 3-4 months of age, eight sensitized rabbits were anesthetized and relaxed with a mixture of ketamine hydrochloride (44 mg/kg) and acepromazine maleate (0 4 mg/kg) admmistered mtramuscularly The rabbits were then laid supme in a comfortable position on a small molded, padded animal board and mtubated with a 4 0-mm mtratracheal tube (Mallmkrodt, Inc , Glens Falls, NY) A polyethylene catheter of external diameter 2 4 mm with an attached latex balloon was passed mto the esophagus and mamtamed at the same distance (approximately 16 cm) from the mouth throughout the experiments The mtratracheal tube was attached to a heated Fleisch pneumotachograph (size 00, DOM Medical, Richmond, VA), and flow was measured usmg a Vahdyne differential pressure transducer (Model DP-45161927, Va dyne Engmeenng Corp , Northndge, CA) dnven by a Gould earner amplifier (Model 1 1-41 13, Gould Electronic, Cleveland, OH) The esophageal balloon was attached to one side of the differential pressure transducer, and the outflow of the mtratracheal tube was connected to the opposite side of the pressure transducer to allow recording of transpulmonary pressure Flow was integrated to give a contmuous tidal volume, and measurements of total lung resistance (RL) and dynamic compliance (Cdyn) were calculated at lsovolumetnc and flow zero points, respectively, usmg an automated respiratory analyzer (Model 6, Buxco, Sharon, CT) Animals were randomized and on Day 1 pretreatment values for PC50 were obtained for aerosolized adenosme Anti-sense (HAdAlAS) or mismatched control (HAdAlMM) oligonucleotides were dissolved in sterile physiological saline at a concentration of 5000 g (5 mg) per 1 0 ml Animals were subsequently admmistered the aerosolized anti-sense or mismatch oligonucleotide via the mtratracheal tube (approximately 5000 g m a volume of 1 0 ml), twice daily for two days Aerosols of either salme, adenosine, or anti-sense or mismatch oligonucleotides were generated by an ultrasonic nebulizer (DeVilbiss, Somerset, PA), producing aerosol droplets 80% of which were smaller than 5 m m diameter In the first arm of the experiment, four randomly selected allergic rabbits were admmistered anti-sense oligonucleotide and four the mismatched control oligonucleotide On the mommg of the thud day, PC50 values (the concentration of aerosolized adenosme m mg/ml requued to reduce the dynamic compliance of the bronchial airway 50% from the baseline value) were obtained and compared to PC50 values obtamed for these animals pnor to exposure to oligonucleotide Following a 1 week interval, animals were crossed over, with those previously admmistered mismatch control oligonucleotide now administered anti-sense oligonucleotide, and those previously treated with anti-sense oligonucleotide now admmistered mismatch control oligonucleotide Treatment methods and measurements were identical to those employed m the first arm of the experiment It should be noted that m six of the eight animals treated with anti-sense oligonucleotide, adenosme-mediated bronchoconstnction could not be obtamed up to the limit of solubility of adenosine, 20 mg/ml For the purpose of calculation, PC50 values for these animals were set at 20 mg/ml The values given therefore represent a minimum figure for anti-sense effectiveness Actual effectiveness was higher The results of this experiment are illustrated in Table 3 below Table 3: Effect of Adenosine A, Receptor Anti-sense Oligo upon PC50 Values m Asthmatic Rabbits

Mismatch Control A, Receptor Anti-sense Oligo

Pre Oligonucleotide Post Oligonucleotide Pre Oligonucleotide Post Oligonucleotide

3 56 + 1 02 5 16 + 1 03 2 36 + 0 68 >19 5 ± 0 34**

The results are presented as the mean (n=8) + SEM

The significance was determined by repeated-measures analysis of variance (ANOVA), and Tukey's protected test

"Significantly different from all other groups, p<0 01

In both arms of the experiment, animals receivmg the anti-sense oligonucleotide showed an order of magnitude mcrease in the dose of aerosolized adenosme required to reduce dynamic compliance of the lung by 50% No effect of the mismatched control oligonucleotide upon PC50 values was observed No toxicity was observed m any animal receivmg either anti-sense or control inhaled oligonucleotide These results show clearly that the lung has exceptional potential as a target for anti-sense o gonucleotide-based therapeutic intervention in lung disease They further show, m a model system which closely resembles human asthma, that downregulation of the adenosme A, receptor largely eliminates adenosme-mediated bronchoconstriction m asthmatic airways Bronchial hyperresponsiveness m the allergic rabbit model of human asthma is an excellent endpomt for anti-sense intervention since the tissues involved in this response e near to the point of contact with aerosolized oligonucleotides, and the model closely simulates an important human disease Example 4: Specificity of A,-adenosine Receptor Anti-sense Oligonucleotide EPI-109 256

At the conclusion of the cross-over experiment of Example 3 above, airway smooth muscle from all rabbits was quantitatively analyzed for adenosme A, receptor number As a control for the specificity of the anti- sense oligonucleotide, adenosme A₂ receptors, which should not have been affected, were also quantified Airway smooth muscle tissue was dissected from each rabbit and a membrane fracnon prepared accordmg to the method of Kleinstem et al (Klemstem, J. and Glossmann, H , Naunyn-Schmiedeberg's Arch Pharmacol. 305 191-200 (1978)), the relevant portion of which is hereby mcorporated m its entirety by reference, with slight modifications. Crude plasma membrane preparations were stored at 70EC until the time of assay. Protem content was determined by the method of Bradford (M. Bradford, Anal Biochem 72, 240-254 (1976), the relevant portion of which is hereby incorporated m its entirety by reference) Frozen plasma membranes were thawed at room temperature and were mcubated with 0.2 U/ml adenosme deaminase for 30 minutes at 37EC to remove endogenous adenosme. The bmdmg of [³H] DPCPX (A, receptor-specific) or [³H] CGS-21680 (A, receptor-specific) was measured as previously descnbed by A et al. (Ali, S et al , J. Pharmacol. Exp Ther. 268, Am. J. Physiol 266, L271-277 (1994), the relevant portion of which is hereby mcorporated m its entuety by reference) The animals treated with adenosme A, anti-sense oligonucleotide m the cross-over experiment had a nearly 75% decrease m A, receptor number compared to controls, as assayed by specific bindmg of the A, -specific antagonist DPCPX There was no change in adenosme A₂ receptor number, as assayed by specific bmdmg of the A₂ receptor-specific agonist 2- [p- (2-carboxyethyl)-phenethylamιno] -5' - (N-ethylcarboxarmdo) adenosme (CGS-21680) This is illustrated in Table 4 below Table 4: Specificity of Action of Adenosine A, Receptor Anti-sense Oligonucleotide

Mismatch Control A, Anti-sense Oligonucleotide Oligonucleotide

A,-Specific Binding 1105 + 48** 293 + 18

A₂-Specifϊc Binding 302 + 22 442 + 171

The results are presented as the mean (π = 8) + SEM

The significance was determined by repeated-measures analysis of variance (ANOVA), and Tukey's protected test

•"Significantly different from mismatch control, p<001

The above results illustrate the effectiveness of anti-sense oligonucleotides m treating airway disease Smce the anti-sense oligos descnbed above eliminate the receptor systems responsible for adenosme-mediated bronchoconstriction, it may be less imperative to eliminate adenosme from them However, it would be preferable to eliminate adenosme from even these oligonucleotides to reduce the dose needed to attain a similar effect Described above are other anti-sense oligonucleotides targetmg mRNA of proteins mvolved in inflammation Adenosine has been eliminated from their nucleotide content to prevent its liberation during degradation Example 5: Anti-sense Oligos directed to other Target Nucleic Acids

This work was conducted to demonstrate that the present mvention is broadly applicable to anti-sense oligonucleotides ("oligos") specific to nucleic acid targets broadly The following experimental studies were conducted to show that the method of the mvention is broadly suitable for use with anti-sense oligos designed as taught by this application and targeted to any and all adenosme receptor mRNAs. For this purpose, vanous anti- sense oligos were porepared to adenosme receptor mRNAs exemplified by the adenosme A„ A_2b and A₃ receptor mRNAs Anti-sense Oligo I was disclosed above (SEQ. ID NO:l) Five additional anti-sense phosphorothioate oligos were designed asnd synthesized as indicated above.

1- Oligo II (SEQ. ID NO: 7) also targeted to the adenosme A, receptor, but to a different region than Oligo I

2- Oligo V (SEQ. ID NO: 10) targeted to the adenosme A_2b receptor

3- Oligos III (SEQ. ID NO: 8) and IV (SEQ. ID NO: 9) targeted to different regions ofthe adenosme A₃ receptor

4- Oligo I-PD (SEQ. ID NO: 1681)(a phosphodiester oligo of the same sequence as Oligo I).

These anti-sense oligos were designed for therapy on a selected species as descnbed above and are generally specific for that species, unless the segment of the target mRNA of other species happens to contain a similar sequences. All anti-sense oligos were prepared as descnbed below, and tested in vivo m a rabbit model for bronchoconstriction, inflammation and allergy, which have breathing difficulties and impeded lung airways, as is the case m ailments such as asthma, as descnbed m the above-identified application. Example 6: Design & Sequences of other Anti-sense Oligos EPI-109 257

Six oligos and theu effects m a rabbit model were studied and the results of these studies are reported and discussed below Five of these oligos were selected for this study to complement the data on Oligo I (SEQ ID NO: 1) provided m Examples 1 to 4 above This oligo is anti-sense to one region of the adenosme A, receptor mRNA The oligos tested are identified as anti-sense Oligos I (SEQ ID NO: 1) and II (SEQ. ID No: 7) targeted to a different region of the adenosine A, receptor mRNA, Oligo V (SEQ. ID No:8) targeted to the adenosme A_2b receptor mRNA, and anti-sense Oligos III and IV (SEQ. ID NOS: 9 and 10) targeted to two different regions ofthe adenosine A₃ receptor mRNA The sixth oligo (Oligo I-PD) is a phosphodiester version of Oligo I (SEQ. ID NO:l) The design and synthesis of these anti-sense oligos was performed m accordance with Example 1 above

(I) Anti-sense Oligo I: The anti-sense oligonucleotide I refened to m Examples 1 to 4 above is targeted to the human A, adenosme receptor mRNA (EPI 2010) Anti-sense oligo I is 21 nucleotide long, overlaps the initiation codon, and has the following sequence 5'- GAT GGA GGG CGG CAT GGC GGG -3' ( SEQ. ID No 1) The oligo I was previously shown to abrogate the adenosme-mduced bronchoconstriction in allergic rabbits, and to reduce allergen-induced airway obstruction and bronchial hyperresponsiveness (BHR), as discussed above and shown by Nyce, J W & Metzger, W J , Nature, 385 721 (1977), the relevant portions of which reference are mcorporated m their entireties herein by reference

(II) Anti-sense Oligo II: A phosphorothioate anti-sense oligo (SEQ. ID NO:7) was designed m accordance with the mvention to target the rabbit adenosine A, receptor mRNA region +936 to +956 relative to the initiation codon (start site) The anti-sense oligo II is 21 nucleotide long, and has the following sequence 5'-CTC GTC GCC GTC GCC GGC GGG-3' (SEQ. ID NO:7).

(III) Anti-sense Oligo III: A phosphorothioate anti-sense oligo other than that provided in Example 1 above (SEQ. ID NO:8) was designed m accordance with the mvention to target the anti-sense A₃ receptor mRNA region +3 to + 22 relative to the initiation codon start site The anti-sense oligo III is 20 nucleotide long, and has the following sequence 5'-GGG TGG TGC TAT TGT CGG GC-3' (SEQ. ID NO:8).

(IV) Anti-sense Oligo IV: Yet another phosphorothioate anti-sense oligo (SEQ. ID NO:9) was designed m accordance with the mvention to target the adenosme A₃ receptor mRNA region + 386 to + 401 relative to the initiation codon (start site) The anti-sense oligo IV is 15 nucleotide long, and has the following sequence 5'-GGC CCA GGG CCA GCC-3' (SEQ. ID NO:9).

(V) Anti-sense Oligo V: A phosphorothioate anti-sense oligo (SEQ. ID NO: 10) was designed in accordance with the invention to target the adenosine A_2b receptor mRNA region -21 to - 1 relative to the initiation codon (start site) The anti-sense oligonucleotide V is 21 nucleotide long, and has the following sequence 5'-GGC CGG GCC AGC CGG GCC CGG-3' (SEQ. ID NO:10).

(VI) A, Mismatch Oligos: Two different mismatched oligonucleotides having the following sequences were used as controls for anti-sense oligo I (SEQ. ID NO: 1) described m Example 5 above

A, MM2 5'-GTA GGT GGC GGG CAA GGC GGG-3' (SEQ. ID NO:1682) A, MM3 5'-GAT GGA GGC GGG CAT GGC GGG-3' (SEQ. ID NO:1683)

Anti-sense o go I and the two mismatch anti-sense oligos had identical base content and general sequence structure Homology searches m GENBANK (release 85 0) and EMBL (release 40 0) indicated that the anti-sense ohgo 1 was specific, not only for the human, but also for the rabbit, adenosine A, receptor genes, and that the mismatched controls were not candidates for hybridization with any known human or animal gene sequence

(VII) Anti-sense Oligo A,-PD (Oligo VI): A phosphodiester anti-sense o go (Oligo VI; SEQ. ID NO:1681) havmg the same nucleotide sequence as Ohgo I was designed as disclosed in the above-identified application Anti- sense ohgo I-PD is 21 nucleotide long, overlaps the initiation codon, and has the following sequence:

5'- GAT GGA GGG CGG CAT GGC GGG -3' (SEQ. ID NO:1681)

(VIII) Controls: Each rabbit was admmistered 5 0 ml aerosolized stenle saline following the same schedule as for the anti-sense oligos m (II), (III), and (IV) above

Example 7: Synthesis of Anti-sense Oligos

Phosphorothioate anti-sense oligos having the sequences descnbed in (a) above, were synthesized on an Applied Biosystems Model 396 Oligonucleotide Synthesizer, and punfied usmg NENSORB chromatography (DuPont, DE) TETD (tetraethylthiuram disulfide) was used as the sulfunzing agent during the synthesis Anti- sense oligonucleotide II (SEQ. ID NO:7), anti-sense oligonucleotide III (SEQ. ID NO: 8) and anti-sense oligonucleotide IV (SEQ. ID NO: 9) were each synthesized and purified in this manner Example 8: Preparation of Allergic Rabbits EPI-109 258

Neonatal New Zealand white Pasturella-free rabbits were immunized lntrapeπtoneally withm 24 hours of birth with 0.5 ml of 312 antigen units/ml house dust mite (D fannae) extract (Berkeley Biologicals, Berkeley, CA) mixed with 10% kaolm as previously descnbed (Metzger, W J , in Late Phase Allergic Reactions, Dorsch, W., Ed., CRC Handbook, pp 347-362, CRC Press, Boca Raton (1990); A , S., Metzger, W. J. and Mustafa, S. J., Am. J Resp. Cπt. Care Med. 149- 908 (1994)), the relevant portions of which are mcorporated m then entireties here by reference Immunizations were repeated weekly for the first month and then biweekly until the age of 4 months These rabbits preferentially produce allergen-specific IgE antibody, typically respond to aeroallergen challenge with both an early and late-phase asthmatic response, and show bronchial hyper responsiveness (BHR) Monthly mtraperitoneal admmistration of allergen (312 units dust mite allergen, as above) contmues to stimulate and mamtain allergen-specific IgE antibody and BHR At 4 months of age, sensitized rabbits were prepared for aerosol admmistration as descnbed by Ah et al. (Ah, S , Metzger, W J. and Mustafa, S. J., Am J. Resp. Cπt. Care Med 149 (1994)), the relevant secnon being incorporated in its entirety here by reference. DOSE-RESPONSE STUDIES Example 9: Experimental Setup

Aerosols of either adenosine (0-20 mg/ml), or anti-sense or one of two mismatch oligonucleotides (5 mg/ml) were separately prepared with an ultrasonic nebulizer (Model 646, DeVilbiss, Somerset, PA), which produced aerosol droplets. 80% of which were smaller than 5.m m diameter Equal volumes of the aerosols were admmistered directly to the lungs via an mtratracheal tube The animals were randomized, and admmistered aerosolized adenosine Day 1 pre-treatment values for sensitivity to adenosme were calculated as the dose of adenosine causing a 50% loss of compliance (PC₅₀ Adenosme) The animals were then admmistered either the aerosolized anti-sense or one of the mismatch anti-sense oligos via the mtratracheal tube (5 mg/1.0 ml), for 2 minutes, twice daily for 2 days (total dose, 20 mg). Post-treatment PC₅₀ values were recorded (post-treatment challenge) on the mommg of the thud day The results of these studies are provided m Example 21 below. Example 10: Crossover Experiments

For some expenments utilizing anti-sense ohgo I (SEQ ID NO: 1) and a corresponding mismatch control oligonucleotide A1MM2, following a 2 week interval, the animals were crossed over, with those previously admmistered the mismatch control A,MM2, now receivmg the anti-sense ohgo I, and those previously treated with the anti-sense o go I, now receiving the mismatch control A,MM2 ohgo The number of animals per group was as follows For mismatch A,MM2 (Control 1), n=7, since one animal was lost m the second control arm of the experiment due to technical difficulties, for mismatch A,MM3 n=4 (Control 2) and for A,AS anti-sense o go I, n=8. The A,MM3 o go-treated animals were analyzed separately and were not part of the cross-over expeπment The treatment methods and measurements employed following the cross-over were identical to those employed in the first arm of the expenment In 6 of the 8 animals treated with the anti-sense o go I (SEQ. ID NO: 1), no PC₅₀ value could be obtained for adenosine doses of up to 20 mg/ml, which is the limit of solubility of adenosine Accordmgly, the PC₅₀ values for these animals were assumed to be 20 mg/ml for calculation purposes The values given, therefore, represent a minimum figure for the effectiveness of the anti-sense oligonucleotides of the invention. Other groups of allergic rabbits (n=4 for each group) were admmistered 0.5 or 0 05 mg doses of the anti- sense o go I (SEQ ID NO: 1), or the A,MM2 o go in the manner and accordmg to the schedule descnbed above (the total doses bemg 2.0 or 0.2 mg) The results of these studies are provided in Example 22 below. Example 11: Anti-sense Oligo Formulation

Each one of anti-sense oligos were separately solubiltzed m an aqueous solution and admmistered as descnbed for anti-sense o go I (SEQ. ID No:l) in (e) above, m four 5 mg aliquots (20 mg total dose) by means of a nebulizer via endotracheal tube, as descπbed above. The results obtamed for anti-sense o go I and its mismatch controls confirmed that the mismatch controls are equivalent to salme, as descnbed m Example 19 below and m Table 1 of Nyce & Metzger, Nature 385, 721-725 (1997) Because of this findmg, salme was used as a control for pulmonary function studies employing anti-sense oligos II, III and IV (SEQ. ID NOS; 7, 8 and 9) Example 12: Specificity of Oligo I for Adenosine A, Receptor (Receptor Binding Studies)

Tissue from airway smooth muscle was dissected to primary, secondary and tertiary bronchi from rabbits which had been admmistered 20 mg o go I (SEQ ID NO: 1) in 4 divided doses over a penod of 48 hours as described above A membrane fraction was prepared according to the method of Ah et al (Ah, S , et al , Am J Resp. Cπt Care Med. 149 908 (1994), the relevant section relating to the preparation of the membrane fraction is incorporated m its entirety hereby by reference) The protein content was determined by the method of Bradford EPI-109 259 and plasma membranes were incubated with 0.2 U/ml adenosine deaminase for 30 minutes at 37EC to remove endogenous adenosine. See, Bradford, M. M. Anal. Biochem. 72, 240-254 (1976), the relevant portion of which is hereby incorporated in its entirety by reference. The binding of [³H]DPCPX, [³H]NPC 17731, or [³H]CGS-21680 was measured as described by Jarvis et al. See, Jarvis, M.F., et al., Pharmacol. Exptl. Ther. 251, 888-893 (1989), the relevant portion of which is fully incorporated herein by reference. The results of this study are shown in Table

8 and discussed in Example 20 below.

Example 13: Pulmonary Function Measurements (Compliance c_DYN and Resistance)

At 4 months of age, the immunized animals were anesthetized and relaxed with 1.5 ml of a mixture of ketamine HCl (35 mg/kg) and acepromazine maleate (1.5 mg/kg) administered intramuscularly. After induction of anesthesia, allergic rabbits were comfortably positioned supine on a soft molded animal board. Salve was applied to the eyes to prevent drying, and they were closed. The animals were then intubated with a 4.0 mm intermediate high-low cuffed Murphy 1 endotracheal tube (Mallinckrodt, Glen Falls, NY), as previously described by Zavala and Rhodes. See, Zavala and Rhodes, Proc. Soc. Exp. Biol. Med. 144: 509-512 (1973), the relevant portion of which is incorporated herein by reference in its entirety. A polyethylene catheter of OD 2.4 mm (Becton Dickinson, Clay Adams, Parsippany NJ) with an attached thin-walled latex balloon was passed into the esophagus and maintained at the same distance (approximately 16 cm) from the mouth throughout the experiment. The endotracheal tube was attached to a heated Fleisch pneumotach (size 00; DEM Medical, Richmond, VA), and the flow (v) measured using a Vahdyne differential pressure transducer (Model DP-45-16-1927, Validyne Engineering, Northridge, CA), driven by a Gould carrier amplifier (Model 1 1-4113, Gould Electronics, Cleveland, OH). An esophageal balloon was attached to one side of the Validyne differential pressure transducer, and the other side was attached to the outflow of the endotracheal tube to obtain transpulmonary pressure (P_tp). The flow was integrated to yield a continuous tidal volume, and the measurements of total lung resistance (R,) and dynamic compliance (C_dy_) were made at isovolumetric and zero flow points. The flow, volume and pressure were recorded on an eight channel Gould 2000 W high-frequency recorder and C_dyn was calculated using the total volume and the difference in P_φ at zero flow, and . R, was calculated as the ratio of Ptp and V at midtidal lung volumes. These calculations were made automatically with the Buxco automated pulmonary mechanics respiratory analyzer (Model 6, Buxco Electronics, Sharon, CT), as previously described by Giles et al. See, Giles et al., Arch. Int. Pharmacodyn. Ther. 194: 213-232 (1971), the relevant portion of which describing these calculations is incorporated in toto hereby by reference. The results obtained upon administration of oligo II on allergic rabbits are shown and discussed in Example 26 below. Example 14: Measurement of Bronchial Hyperresponsiveness (BHR)

Each allergic rabbit was administered histamine by aerosol to determine their baseline hyperresponsiveness. Aerosols of either saline or histamine were generated using a DeVilbiss nebulizer (DeVilbiss, Somerset, PA) for 30 seconds and then for 2 minutes at each dose employed. The ultrasonic nebulizer produced aerosol droplets of which 80% were <5 micron in diameter. The histamine aerosol was administered in increasing concentrations (0.156 to 80 mg/ml) and measurements of pulmonary function were made after each dose. The B4R was then determined by calculating the concentration of histamine (mg/ml) required to reduce the C_dyn 50% from baseline (PC_{50 Hisamim}).

Example 15: Cardiovascular Effect of Anti-sense Oligo I The measurement of cardiac output and other cardiovascular parameters using CardiomaxJ utilizes the principal of thermal dilution in which the change in temperature of the blood exiting the heart after a venous injection of a known volume of cool saline is monitored. A single rapid injection of cool saline was made into the right atrium via cannulation of the right jugular vein, and the conesponding changes in temperature of the mixed injectate and blood in the aortic arch were recorded via cannulation of the carotid artery by a temperature-sensing miniprobe. Twelve hours after the allergic rabbits had been treated with aerosols of oligo I (EPI 2010; SEQ. ID NO: 1) as described in (d) above, the animals were anesthetized with 0.3 ml/kg of 80% Ketamine and 20% Xylazine. This time point coincides with previous data showing efficacy for SEQ. ID NO: 1, as is clearly shown by Nyce & Metzger, (1997), supra, the pertinent disclosure being incorporated in its entirety here by reference. A thermocouple was then inserted into the left carotid artery of each rabbit, and was then advanced 6.5 cm and secured with a silk ligature. The right jugular vein was then cannulated and a length of polyethylene tubing was inserted and secured. A thermodilution curve was then established on a CardiomaxJ II (Columbus Instruments, Ohio) by injecting sterile saline at 20EC to determine the correctness of positioning of the EPI-109 260 thermocouple probe After establishmg the correcmess of the position of the thermocouple, the femoral artery and vem were isolated The femoral vein was used as a portal for drug mjections, and the femoral artery for blood pressure and heart rate measurements Once constant baselme cardiovascular parameters were established,

CardiomaxJ measurements of blood pressure, heart rate, cardiac output, total penpheral resistance, and cardiac contractility were made

Example 16: Duration of Action of Ohgo I (SEQ. ID NO: 1)

Eight allergic rabbits received initially increasing log doses of adenosme by means of a nebulizer via an lntra-tracheal tube as descnbed m (f) above, beginning with 0 156 mg/ml until compliance was reduced by 50% (PC_{50 Adenos e}) ^t0 establish a baselme Six of the rabbits then received four 5 mg aerosolized doses of (SEQ. ID NO: 1) as described above Two rabbits received equivalent amounts of salme vehicle as controls Beginning 18 hours after the last treatment, the PC_{50 A-en∞me} values were tested agam After this point, the measurements were contmued for all animals each day, for up to 10 days The results of this study are discussed m Example 25 below Example 17: Reduction of Adenosine A_2b Receptor Number by Anti-sense Oligo V

Sprague Dawley rats were admmistered 2 0 mg respirable anti-sense ohgo V (SEQ ID NO: 10) three tunes over two days usmg an inhalation chamber as descnbed above Twelve hours after the last admmistration, lung parenchymal tissue was dissected and assayed for adenosine A_2b receptor bmdmg usmg [311]-NECA as descπbed by Nyce & Metzger ( 1997), supra Controls were conducted by admmistration of equal volumes of salme The results are significant at p<0 05 usmg Student's paired t test, and are discussed m Example 28 below Example 18: Comparison of Oligo I & Corresponding Phosphodiester Ohgo VI (SEQ. ID NO:1681)

Ohgo I (SEQ ID NO:l) countered the effects of adenosine and eliminated sensitivity to it for adenosme amounte up to 20 mg adenosme/5 0 ml (the limit of solubility of adenosme) Ohgo VI (SEQ ID NO:1681), the phosphodiester version of the oligonucleotide sequence, was completely ineffective when tested m the same manner Both compounds have identical sequence, differing only m the presence of phosphorothioate residues in Ohgo I (SEQ ID NO:l), and were delivered as an aerosol as descπbed above and m Nyce & Metzger ( 1997), supra Significantly different at p<0 001, Student's paued t test The results are discussed in Example 29 below RESULTS OBTAINED FOR ANTI-SENSE OLIGO I (SEQ. ID NO: 1) Example 19: Results of Prior Work

The nucleotide sequence and other data for anti-sense o go I (SEQ. ID NO: 1), which is specific for the adenosine A, receptor, were provided above The experimental data showing the effectiveness of ohgo I in down regulating the receptor number and activity were also provided above Further information on the charactenstics and activities of anti-sense ohgo I is provided in Nyce, J W and Metzger, W J , Nature 385 721 ( 1997), the relevant parts of which relatmg to the following results are incorporated in their entireties herem by reference The Nyce & Metzger (1997) publication provided data showing that the anti-sense ohgo I (SEQ. ID NO: 1)

(1 ) The anti-sense o go I reduces the number of adenosine A, receptors m the bronchial smooth muscle of allergic rabbits m a dose-dependent manner as may be seen m Table 5

(2) Anti-sense Ohgo I attenuates adenosme-mduced bronchoconstπction and allergen-induced bronchoconstnction

(3) The Ohgo I attenuates bronchial hypenesponsiveness as measured by PC₅₀ histamme, a standard measurement to assess bronchial hyperresponsiveness This result clearly demonstrates anti-inflammatory activity of the anti- sense o go I as is shown m Table 5

(4) As expected, because it was designed to target it, the anti-sense o go I is totally specific for the adenosme A, receptor, and has no effect at all at any dose on either the very closely related adenosme A₂ receptor or the related bradykimn B₂ receptor This is seen m Table 5

(5) In contradistinction to the above effects of the O go I, the mismatch control molecules MM2 and MM3 (SEQ. ID NO:1682 and SEQ. ID NO:1683) which have identical base composition and molecular weight but differed from the anti-sense o go I (SEQ ID NO: 1) by 6 and 2 mismatches, respectively These mismatches, which are the minimum possible while still retammg identical base composition, produced absolutely no effect upon any of the targeted receptors (A,, A₂ or B₂)

These results, along with a complete lack of prior art on the use of anti-sense oligonucleotides, such as ohgo I, targeted to the adenosine A, receptor, are unexpected results The showings presented in this patent clearly enable and demonstrate the effectiveness, for their mtended use, of the claimed agents and method for treating a disease or condition associated with lung airway, such as bronchoconstnction, inflammation, allergy(ιes), and the like Example 20: Ohgo I Significantly Reduces Response to Adenosine Challenge

The receptor bmdmg experiment is descnbed m Example 12 above, and the results shown m Table 5 below which shows the bmdmg characteπstics of the adenosme A, -selective ligand [₃H]DPCPX and the bradykmm B₂-selectιve ligand [³H]NPC 17731 m membranes isolated from airway smooth muscle of A, adenosme receptor and B₂ bradykmm receptor ann-sense- and mismatch-treated allergic rabbits

Table 5: Binding Characteπstics of Three Anti-Sense Oligos

Treatment¹ A, receptor B; receptor

Kd B... Kd Bmax

Adenosme A, Receptor

20 mg 0 36+0 029 nM 19+1 52 fmoles* 0 39+0 031 nM 14 8+0 99fmoles

2 mg 0 38+0 030 nM 32+2 56 fmoles* 0 41+0 028 nM 15 5+1 08 fmoles

0 2 mg 0 37+0 030 nM 49+3 43 fmoles 0 34+0 024 nM 15 0+1 06 fmoles

A,MM1 (Control)

20 mg 0 34+0 027 nM 52 0+3 64 fmoles 0 35+0 024 nM 14 0+1 0 fmoles

2 mg 0 37+0 033 nM 51 8+3 88 fmoles 0 38+0 028 nM 14 6+1 02 fmoles

B;Λ (Bradvkinin Receptor)

20 mg 0 36+0 028 nM 45 0+O 15 fmoles 0 38+0 027 nM 8 7+0 62 fmoles*

2 mg 0 39+0 035 nM 44 3+2 90 fmoles 0 34+0 024 nM 11 9+0 76 fmoles"

0.2 mg 0 40+0 028 nM 47 0+3 76 fmoles 0 35+0 028 nM 15 1+1 05 fmoles

B,MM (Control) +

20 mg 0 39+0 031 nM 42 0+2 94 fmoles 0 41+0 029 nM 14 0+0 98 fmoles

2 mg 0 41+0 035 nM 40 0+3 20 fmoles 0 37+0 030 nM 14 8+0 99 fmoles

0.2 mg 0 37+0 029 nM 43 0+3 14 fmoles 0 36+0 025 nM 15 1+1 35 fmoles

Salme Control 0 37+0 041 46 0+5 21 0 39+0 047 nM 14 2+1 35 fmoles

¹ Refers to total oligo aαmmistereα in tour equivalently divided doses over a 48 hour peπod Treatments and analyses were performed as descnbed in methods Significance was determined by repeated-measures analysis of vaπance (ANOVA) anϊukey s protected t test n = 4-6 for all groups ' Significantly different from mismatcn control- and saline treated groups p<0001 "Significantly different from mismatch control- and saline-treated groups p<005

Example 21 : Dose-response Effect of Oligo I

Anti-sense oligo I (SEQ ID NO:l) was found to reduce the effect of adenosme admmistration to the animal in a dose-dependent manner over the dose range tested as shown m Table 6 below EPI-109 262

Table 6: Dose-Response Effect to Anti-sense Oligo I

Total Dose PC_{50 Aitammt}

(mg) (mg Adenosme)

Anti-sense Oligo I

0.2 8.32+7.2

2.0 14.0+7.2

20 19.5+0.34

A,MM2 oligo (control)

0.2 2.51+0.46

2.0 3.13+0.71

20 3.25+0.34

The above results were found by the Student's paired t test statistically different, p=005

The ohgo I (SEQ. ID NO:l), an anti-adenosme A, receptor oligo, acts specifically on the adenosine A, receptor, but not on the adenosine A, receptors. These results stem from the treatment of rabbits with anti-sense ohgo I (SEQ. ID NO.l) or mismatch control ohgo (SEQ. ID NO:1682, A.MM2) as descnbed in Example 9 above and in Nyce & Metzger (1997), supra (four doses of 5 mg spaced 8 to 12 hours apart via nebulizer via endotracheal tube), bronchial smooth muscle tissue excised and the number of adenosine A, and adenosine A₂ receptors determined as reported in Nyce & Metzger (1997), supra. Example 22: Specificity of Oligo I (SEQ. ID NO:l) for Target Gene Product

O go I (SEQ. ID No 1) is specific for the adenosme A, receptor whereas its mismatch controls had no activity Figure 1 depicts the results obtained from the cross-over expenment descnbed m Example 10 above and in Nyce & Metzger (1997), supra The two mismatch controls (SEQ. ID NO:1682 and SEQ. ID NO:1683) evidenced no effect on the PC_{50 A<Jm0Slnc} value On the contrary, the administration of anti-sense ohgo I (SEQ. ID NO:l) showed a seven-fold increase m the PC_{50 Adcnosιnc} value The results clearly indicate that the anti-sense ohgo I (SEQ. ID NO: 1) reduces the response (attenuates the sensitivity) to exogenously admmistered adenosine when compared with a salme control The results provided in Table 2 above clearly establish that the effect of the anti- sense o go I is dose dependent (see, column 3 of Table 1) The Ohgo I was also shown to be totally specific for the adenosine A, receptor, (see, top 3 rows of Table), inducing no activity at either the closely related adenosine A₂ receptor or the bradykmm B₂ receptor (see, lmes 8-10 of Table 2 above) In addition, the results shown in Table 2 establish that the anti-sense ohgo I (SEQ. ID NO:l) decreases sensitivity to adenosme m a dose dependent manner, and that it does this m an anti-sense ohgo-dependent manner since neither of two mismatch control oligonucleotides (A.MM2, SEQ. ID NO:1682 and A.MM3, SEQ. ID NO:1683) show any effect on PC_{50 Adenosln}. values or on attenuating the number of adenosme A, receptors. Example 23: Effect on Aeroallergen-induced Bronchoconstriction & Inflammation

The Ohgo I (SEQ. ID NO:l) was shown to significantly reduce the histamine-induced effect in the rabbit model when compared to the mismatch oligos. The effect of the anti-sense O go I (SEQ. ID No. l) and the mismatch oligos (A,MM2, SEQ. ID NO:1682 and A,MM3, SEQ. ID NO:1682) on allergen-induced airway obstruction and bronchial hyperresponsiveness was assessed in allergic rabbits The effect of the anti-sense o go I (SEQ. ID NO:l) on allergen-mduced airway obstruction was assessed As calculated from the area under the plotted curve, the anti-sense oligo I significantly inhibited allergen-mduced airway obstruction when compared with the mismatched control (55%, p<0 05; repeated measures ANOVA, and Tukey's t test) A complete lack of effect was mduced by the mismatch o go A,MM2 (Control) on allergen induced airway obstruction The effect of the anti-sense o go I (SEQ. ID NO:l) on allergen-mduced BHR was determined as above As calculated from the PC_{50 H},_{SIam e} value , the anti-sense ohgo I (SEQ. ID NO:l) significantly inhibited allergen-mduced BHR in allergic rabbits when compared to the mismatched control (61%, p<0 05; repeated measures ANOVA, Tukey's t test) A complete lack of effect of the A,MM mismatch control on allergen-mduced BHR was observed. The results indicated that anti-sense oligo I (SEQ. ID NO: 1) is effective to protect agamst aeroallergen-induced bronchoconstnction (house dust mite) In addition, the anti-sense o go I (SEQ. ID NO:l) was also found to be a EPI-109 263 potent inhibitor of dust mite-induced bronchial hyper responsiveness, as shown by its effects upon histamme sensitivity which mdicates and- inflammatory activity for anti-sense ohgo I (SEQ. ID NO:l). Example 24: Anti-sense Oligo I is Free of Deleterious Side Effects

The Ohgo I (SEQ. ID NO:l) was shown to be free of side effects that might be toxic to the recipient. No changes in arteπal blood pressure, cardiac output, stroke volume, heart rate, total peπpheral resistance or heart contractility (dPdT) were observed following admmistration of 2.0 or 20 mg ohgo I (SEQ. ID NO:l) The addition, the results ofthe measurement of cardiac output (CO), stroke volume (SV), mean arterial pressure (MAP), heart rate (HR), total peπpheral resistance (TPR), and contractility (dPdT) with a CardiomaxJ apparatus (Columbus Instruments, Ohio) were assessed These results evidenced that o go I (SEQ. ID NO:l) has no detrimental effect upon critical cardiovascular parameters More particularly, this ohgo does not cause hypotension. This findmg is of particular importance because other phosphorothioate anti-sense oligonucleotides have been shown m the past to induce hypotension m some model systems Furthermore, the adenosme A, receptor plays an important role m sinoatnal conduction withm the heart Attenuation of the adenosme A, receptor by anti-sense ohgo I (SEQ. ID NO:l) might be expected to result, therefore, in deleterious extrapulmonary activity in response to the downregulation of the receptor This is not the case The anti-sense o go I (SEQ. ID NO:l) does not produce any deleteπous intrapulmonary effects and renders the administration of the low doses of the present anti-sense ohgo free of unexpected, undesirable side effects This demonstrates that when o go I (SEQ. ID NO:l) is admmistered directly to the lung, it does not reach the heart m significant quantities to cause deleterious effects This is in contrast to traditional adenosme receptor antagonists like theophyllme which do escape the lung and can cause deleterious, even fe-threatenmg effects outside the lung Example 25: Long Lasting Effect of Oligo I

The O go I (SEQ. ID NO:l) evidenced a long lasting effect as evidenced by the PC₅₀ and Resistance values obtained upon its admmistration prior to adenosine challenge The duration of the effect was measured for with respect to the PC₅₀ of adenosine anti-sense o go I when admmistered m four equal doses of 5 mg each by means of a nebulizer via an endotracheal tube, as descnbed above The effect of the agent is significant over days 1 to 8 after admmistration When the effect of the anti-sense ohgo I (SEQ. ID NO:l) had disappeared, the animals were administered salme aerosols (controls), and the PC_{50 Aάm∞mc} values for all animals were measured again. Saline-treated animals showed base lme PC₅₀ adenosme values (n=6) The duration of the effect (with respect tσ Resistance) was measured for six allergic rabbits which were admmistered 20 mg of anti-sense ohgo I (SEQ. ID NO: 1) as descπbed above, upon airway resistance measured as also descπbed above. The mean calculated duration of effect was 8 3 days for both PC₅₀ adenosine (p<0 05) and resistance (p<0 05) These results show that anti-sense ohgo I (SEQ. ID NO:l) has an extremely long duration of action, which is completely unexpected Example 26: Anti-sense Oligo II

Anti-sense ohgo II, targeted to a different region of the adenosme A, receptor mRNA, was found to be highly active against the adenosine A, -mediated effects The expenment measured the effect of the admmistration of anti-sense ohgo II (SEQ. ID NO:7) upon compliance and resistance values when 20 mg anti-sense ohgo II or salme (control) were admmistered to two groups of allergic rabbits as descπbed above Compliance and resistance values were measured following an admmistration of adenosme or salme as descπbed above m Example 13 The effect of the anti-sense o go of the mvention was different from the control m a statistically significant manner, p<0.05 usmg paired t-test, compliance; p<0 01 for resistance. The results showed that anti-sense o go II (SEQ. ID NO:7), which targets the adenosine A, receptor, effectively maintains compliance and reduces resistance upon adenosme challenge. Example 27: Antisense Oligos III and IV

Ohgos III (SEQ. ID NO:8) and IV (SEQ. ID NO:9) were shown to be m fact specifically targeted to the adenosme A₃ receptor by their effect on reducmg inflammation and the number of inflammatory cells present upon separate admmistration of 20 mg of the anti-sense oligos III (SEQ. ID NO:8) and IV (SEQ. ID NO:9) to allergic rabbits as descπbed above. The number of inflammatory cells was determined their bronchial lavage fluid 3 hours later by counting at least 100 viable cells per lavage. The effect of anti-sense oligos III (SEQ. ID NO:8) and IV (SEQ. ID NO:9) upon granulocytes, and upon total cells m bronchial lavage were assessed following exposure to dust mite allergen. The results showed that the anti-sense o go IV (SEQ. ID NO:9) and anti-sense o go III (SEQ. ID NO:8) are very potent anti-inflammatory agents m the asthmatic lung following exposure to dust mite allergen As is known m the art, granulocytes, especially eosinophils are the primary inflammatory cells of EPI-109 264 asthma, and the admmistration of anti-sense oligos III (SEQ. ID NO:8) and IV (SEQ. ID NO:9) reduced their numbers by 40% and 66%, respectivel} Furthermore, anti-sense ohgos IV (SEQ. ID NO:9) and HI (SEQ. ID NO:8) also reduced the total number of cells in the bronchial lavage fluid by 40% and 80%, respectively This is also an important indicator of anti-inflammatory activity by the present anti-adenosme A₃ agents of the invention Inflammation is known to underlie bronchial hyperresponsiveness and allergen-mduced bronchoconstnction m asthma Both anti-sense oligonucleotides III (SEQ. ID NO:8) and IV (SEQ. ID NO:9), which are targeted to the adenosine A₃ receptor, are representative of an important new class of anti-inflammatory agents which may be designed to specifically target the lung receptors of each species Example 28: Anti-sense Oligo V

The anti-sense ohgo V (SEQ. ID NO:10) , targeted to the adenosme A_2b adenosme receptor mRNA was shown to be highly effective at countering adenosine A_2b-medιated effects and at reducmg the number of adenosme A_2b receptors present to less than half Example 29: Unexpected Superiority of Substituted over Phosphodiester-residue Oligo I-DS(SEQ.ID Nθ:l68i)

Oligos I (SEQ. ID NO:l) and I-DS (SEQ. ID NO:1681) were separately administered to allergic rabbits as descnbed above, and the rabbits were then challenged with adenosine The phosphodiester ohgo I-DS (SEQ. ID NO:1681) was statistically significantly less effective in countering the effect of adenosine whereas o go I (SEQ. ID NO:l) showed high effectiveness, evidencmg a PC_{50 Adol0Sm}. of 20 mg Example 30: Anti-sense Oligo VI

For the present work I designed an additional anti-sense phosphorothioate ohgo targeted to the adenosine A, receptor (Ohgo VI) This anti-sense ohgo was designed for therapy on a selected species as descnbed in the above patent application and is generally specific for that species, unless the segment of the adenosine receptor mRNA of other species elected happens to have a similar sequence The anti-sense oligos were prepared as descnbed below, and tested m vivo in a rabbit model for bronchoconstnction, inflammation and lung allergy, which have breathing difficulties and impeded lung airways, as is the case m ailments such as asthma, as described in the above-identified application One additional ohgo and its effect m a rabbit model was studied and the results of the study are reported and discussed below The present ohgo (anti-sense ohgo VI) was selected for this study to complement the data on SEQ ID NO 1 (O go I), which is anti-sense to the adenosme A, receptor mRNA provided m the above-identified patent application This additional ohgo is identified as anti-sense O go VI, and is targeted to a different region of the adenosme A, receptor mRNA than Ohgo I The design and synthesis of this anti-sense ohgo was performed m accordance with the teachmg, particularly Example 1, of the above-identified patent application The anti-sense Ohgo VI is a phosphorothioate designed to target the cod g region of the rabbit adenosine A, receptor mRNA region +964 to +984 relative to the initiation codon (start site) The O go VI was prepared as descπbed in the above-mdicated application, and is 20 nucleotides long The OhgoVI is duected to the adenosine A, receptor gene, and has the following sequence 5'-CGC CGG CGG GTG CGG GCC GG-3' (SEQ. ID NO:_). The phosphorothioate anti-sense O go VI havmg the sequence described m (5) above, was synthesized on an Applied Biosystems Model 396 Oligonucleotide Synthesizer, and punfied usmg NENSORB chromatography (DuPont, DE) TETD (tetraethylthiuram disulfide) was used as the sulfuπzing agent duπng the synthesis Example 31 : Preparation of Allergic Rabbits

Neonatal New Zealand white Pasturella-free rabbits were immunized lntrapeπtoneally withm 24 hours of birth with 0 5 ml of 312 antigen units/ml house dust mite (D fannae) extract (Berkeley Biologicals, Berkeley, CA) mixed with 10% kaolm as previously described (Metzger, W J , m Late Phase Allergic Reactions, Dorsch, W , Ed , CRC Handbook, pp 347-362, CRC Press, Boca Raton, 1990, Ah, S Et al , Am J Resp Cπt Care Med 149 908 (1994)) The immunizations were repeated weekly for the first month and then bi-weekly until the animals were 4 months old These rabbits preferentially produce allergen-specific IgE antibody, typically respond to aeroallergen challenge with both an early and late-phase asthmatic response, and show bronchial hyper responsiveness (BHR) Monthly intrapentoneal administration of allergen (312 units dust mite allergen, as above) continues to stimulate and maintain allergen-specific IgE antibody and BHR At 4 months of age, sensitized rabbits were prepared for aerosol admmistration as descnbed by Ah et al ( 1994), supra Example 32: Adenosine Aerosol Preparation

An adenosme aerosol (20 mg/ml) was prepared with an ultrasonic nebulizer (Model 646, DeVilbiss, Somerset, PA), which produced aerosol droplets, 80% of which were smaller than 5 m m diameter Equal volumes of the aerosols were admmistered directly to the lungs via an mtratracheal tube to all three rabbits The animals EPI-109 265 were then admmistered the aerosolized adenosme and Day 1 pre-treatment values for sensitivity to adenosme were calculated as the dose of adenosme causmg a 50% loss of compliance (PC₅₀ Adenosme) The animals were then admmistered the aerosolized anti-sense via the mtratracheal tube (5 mg/1.0 ml), for 2 minutes, twice daily for 2 days (total dose, 20 mg) Post-treatment PC₃₀ values were recorded (post-treatment challenge) on the morning of the third day The results of these studies are provided m (9) below

Example 33: Anti-sense Oligo Formulation

Each one of anti-sense ohgos were separately solubilized m an aqueous solution and admmistered as descπbed for anti-sense o go I in (e) above, m four 5 mg aliquots (20 mg total dose) by means of a nebulizer via endotracheal tube, as descπbed above Example 34: Oligo VI Reduces Response to Adenosine Challenge as well or Better than Oligo I

Ohgo VI was tested in three allergic rabbits of the characteπstics and readied as described in (7) above and in the above-indicated patent application Ohgo VI targets a section of the coding region of the A, receptor which is different from Ohgo I. Both these target sequences were selected randomly from many possible coding region target sequences The three rabbits were treated identically as previously indicated for Ohgo I Bnefly, 5 mg of Ohgo VI were nebulized to the rabbits twice per day at 8 hour intervals, for two days Thereafter, PC₅₀ adenosme studies were performed on the mornmg ofthe third day and compared to pre-treatment PC₅₀ values This protocol is described m more detail in Nyce and Metzger (Nyce & Metzger, Nature 385 721 -725 ( 1997)) The results obtamed for the three rabbits are shown in Table 1 below. Table 1 : PC₅₀ Adenosine before & after Aerosolized Adenosine Treatment

Treatment Time PC₅₀ Adenosine

(mg)

Pre-treatment 3.0+2.1

Post-treatment >20.0*

* maximum achievable dose due to adenosme insolubility in salme

All three animals treated with Ohgo VI completely eliminated sensitivity to adenosine up to the measurable level of the agent shown m Table 1 above That is, the admmistration of the O go VI abrogated the adenosme-mduced bronchoconstnction in the three allergic rabbits The actual efficacy of Ohgo VI is, therefore, greater than could be measured in the expenmental system used By comparing with the previously submitted results for the Ohgo I, it may be seen that the O go VI was found to be as effective, or more, than Ohgo I Example 34: Conclusions

The work descnbed and results discussed in the examples clearly indicates that all anti-sense oligonucleotides designed in accordance with the teachings of the above-identified application were found to be highly effective at countering or reducmg effects mediated by the receptors they are targeted to That is, each and all of the two anti-sense ohgos targeting an adenosme A, receptor mRNA, 1 anti-sense o go targetmg an adenosme A,_b receptor mRNA, and the 2 anti-sense oligos targetmg an A₃ receptor mRNA were shown capable of counteπng the effect of exogenously admmistered adenosine which is mediated by the specific receptor they are targeted to The activity of the anti-sense ohgos of this mvention, moreover, is specific to the target and substitutively fails to inhibit another target. In addition, the results presented also show that the admmistration of the present agents results m extremely low or non-existent deleteπous side effects or toxicity This represents 100% success m providing agents that are highly effective and specific in the treatment of bronchoconstnction and or inflammation This mvention is broadly applicable m the same manner to all gene(s) and correspondmg mRNAs encodmg protems involved m or associated with airway diseases A comparison of the phosphodiester and a version of the same oligonucleotide wherem the phosphodiester bonds are substituted with phosphorothioate bonds evidenced an unexpected supeπoπty for the phosphothiorate oligonucleotide over the phosphodiester anti-sense ohgo. The foregoing examples are illustrative of the present mvention, and are not to be construed as lumtmg thereof The mvention is defined by the following claims, with equivalents of the claims to be included therein EPI-109 266

SEQUENCE LISTING

GENERAL INFORMATION

(I) APPLICANT: East Carolina University et al .

(II) TITLE OF THE INVENTION: LOW ADENOSINE OLIGONUCLEOTIDE AGENT,

COMPOSITION, KIT & TREATMENTS

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(A) APPLICATION NUMBER: PCT/US99/

(B) FILING DATE: 3-AUG-1999

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(B) TYPE: nucleic acid

(C) STRANDEDNESS: single EPI-109 ₂₇₀

(D) TOPOLOGY: linear (11) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:27: AGATGGAGGG CGGCATGGCG GGCACAGGCT GGGC 34

(2) INFORMATION FOR SEQ ID NO: 28:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 28: GATGGAGGGC GGCATGGCGG GCACAGGCTG GGC 33

(2) INFORMATION FOR SEQ ID NO: 29:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:29: ATGGAGGGCG GCATGGCGGG CACAGGCTGG GC 32

(2) INFORMATION FOR SEQ ID NO:30: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 30: TGGAGGGCGG CATGGCGGGC ACAGGCTGGG C 31

(2) INFORMATION FOR SEQ ID NO: 31:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (11) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 31: GGAGGGCGGC ATGGCGGGCA CAGGCTGGGC 30

(2) INFORMATION FOR SEQ ID NO: 32: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 32: GAGGGCGGCA TGGCGGGCAC AGGCTGGGC 29

(2) INFORMATION FOR SEQ ID NO:33:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:33:

AGGGCGGCAT GGCGGGCACA GGCTGGGC 28

(2) INFORMATION FOR SEQ ID NO: 34:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH. 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear (li) MOLECULE TYPE: cDNA

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 34: GGGCGGCATG GCGGGCACAG GCTGGGC 27 EPI-109 271

(2) INFORMATION FOR SEQ ID NO:35:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ll) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:35: GGCGGCATGG CGGGCACAGG CTGGGC 26

(2) INFORMATION FOR SEQ ID NO: 36:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:36: GCGGCATGGC GGGCACAGGC TGGGC 25

(2) INFORMATION FOR SEQ ID NO: 37: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 37: CGGCATGGCG GGCACAGGCT GGGC 24

(2) INFORMATION FOR SEQ ID NO: 38:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 38: GGCATGGCGG GCACAGGCTG GGC 23

(2) INFORMATION FOR SEQ ID NO: 39:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:39: GCATGGCGGG CACAGGCTGG GC 22

(2) INFORMATION FOR SEQ ID NO: 40:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:40: CATGGCGGGC ACAGGCTGGG C 21

(2) INFORMATION FOR SEQ ID NO: 1:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ll) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:41: ATGGCGGGCA CAGGCTGGGC 20

(2) INFORMATION FOR SEQ ID NO: 2: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid EPI-109 272

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (11) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 42: TGGCGGGCAC AGGCTGGGC 19

(2) INFORMATION FOR SEQ ID NO: 43:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 43: GGCGGGCACA GGCTGGGC 18

(2) INFORMATION FOR SEQ ID NO: 4:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 44: GCGGGCACAG GCTGGGC 17

(2) INFORMATION FOR SEQ ID NO: 45:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: Single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 5: CGGGCACAGG CTGGGC 16

(2) INFORMATION FOR SEQ ID NO: 46:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 46: GGGCACAGGC TGGGC 15

(2) INFORMATION FOR SEQ ID NO: 47:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 7: GGCACAGGCT GGGC 14

(2) INFORMATION FOR SEQ ID NO: 48:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 8: GCACAGGCTG GGC 13

(2) INFORMATION FOR SEQ ID NO: 49:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 49: CACAGGCTGG GC 12 EPI-109 273

(2) INFORMATION FOR SEQ ID NO: 50: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 50: ACAGGCTGGG C 11

(2) INFORMATION FOR SEQ ID NO: 51: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 51: CAGGCTGGGC 10

(2) INFORMATION FOR SEQ ID NO: 52: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(x ) SEQUENCE DESCRIPTION: SEQ ID NO:52: AGGCTGGGC 9

(2) INFORMATION FOR SEQ ID NO: 53:

(I) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 51 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(II) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 53: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGGCTGGG C 51

(2) INFORMATION FOR SEQ ID NO: 54: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 50 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 54: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGGCTGGG 50

(2) INFORMATION FOR SEQ ID NO: 55: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 49 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: Single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 55: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGGCTGG 49

(2) INFORMATION FOR SEQ ID NO: 56: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 48 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:56: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGGCTG 48

(2) INFORMATION FOR SEQ ID NO: 57: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 47 base pairs

(B) TYPE: nucleic acid EPI-109 274

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (11) MOLECULE TYPE: cDNA

(Xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 57: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGGCT 47

(2) INFORMATION FOR SEQ ID NO: 58: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 46 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 58: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGGC 46

(2) INFORMATION FOR SEQ ID NO: 59: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 45 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

( i) SEQUENCE DESCRIPTION: SEQ ID NO:59: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGG 45

(2) INFORMATION FOR SEQ ID NO: 60: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 44 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 60: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAG 44

(2) INFORMATION FOR SEQ ID NO: 61: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 43 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:61: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACA 43

(2) INFORMATION FOR SEQ ID NO: 62: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 42 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 62: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGGGC AC 42

(2) INFORMATION FOR SEQ ID NO: 63: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 41 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 63: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGGGC A 41

(2) INFORMATION FOR SEQ ID NO: 64:

(I) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 40 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(II) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 64: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGGGC 40 EPI-109 275

(2) INFORMATION FOR SEQ ID NO: 65: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 39 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 65: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGGG 39

(2) INFORMATION FOR SEQ ID NO: 66: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 38 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 66: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGG 38

(2) INFORMATION FOR SEQ ID NO: 67: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 37 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 67: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCG 37

(2) INFORMATION FOR SEQ ID NO: 68: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 36 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 68: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGC 36

(2) INFORMATION FOR SEQ ID NO: 69: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 35 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 69: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGG 35

(2) INFORMATION FOR SEQ ID NO:70: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:70: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATG 34

(2) INFORMATION FOR SEQ ID NO: 71: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 71: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CAT 33

(2) INFORMATION FOR SEQ ID NO: 72: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid EPI-109 276

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (11) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 72: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CA 32

(2) INFORMATION FOR SEQ ID NO: 73: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 73: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG C 31

(2) INFORMATION FOR SEQ ID NO: 74: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 74: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG 30

(2) INFORMATION FOR SEQ ID NO:75: (l) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:75: GGCGGCCTGG AAAGCTGAGA TGGAGGGCG 29

(2) INFORMATION FOR SEQ ID NO:76: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 76: GGCGGCCTGG AAAGCTGAGA TGGAGGGC 28

(2) INFORMATION FOR SEQ ID NO: 77: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 77: GGCGGCCTGG AAAGCTGAGA TGGAGGG 27

(2) INFORMATION FOR SEQ ID NO: 78:

(I) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(II) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 78: GGCGGCCTGG AAAGCTGAGA TGGAGG 26

(2) INFORMATION FOR SEQ ID NO: 79: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 79: GGCGGCCTGG AAAGCTGAGA TGGAG 25 EPI-109 277

(2) INFORMATION FOR SEQ ID NO: 80: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 80: GGCGGCCTGG AAAGCTGAGA TGGA 24

(2) INFORMATION FOR SEQ ID NO: 81: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:81: GGCGGCCTGG AAAGCTGAGA TGG 23

(2) INFORMATION FOR SEQ ID NO: 82: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH. 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:82: GGCGGCCTGG AAAGCTGAGA TG 22

(2) INFORMATION FOR SEQ ID NO: 83: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 83: GGCGGCCTGG AAAGCTGAGA T 21

(2) INFORMATION FOR SEQ ID NO: 84: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 84: GGCGGCCTGG AAAGCTGAGA 20

(2) INFORMATION FOR SEQ ID NO: 85: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:85: GGCGGCCTGG AAAGCTGAG 19

(2) INFORMATION FOR SEQ ID NO: 86:

(I) SEQUENCE CHARACTERISTICS:

(A) LENGTH. 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(II) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 86: GGCGGCCTGG AAAGCTGA 18

(2) INFORMATION FOR SEQ ID NO: 87: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH. 17 base pairs

(B) TYPE: r.ucleic acid EPI-109 278

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (11) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 87: GGCGGCCTGG AAAGCTG 17

(2) INFORMATION FOR SEQ ID NO: 88: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 88: GGCGGCCTGG AAAGCT 16

(2) INFORMATION FOR SEQ ID NO: 89: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 89: GGCGGCCTGG AAAGC 15

(2) INFORMATION FOR SEQ ID NO: 90: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 90: GGCGGCCTGG AAAG 14

(2) INFORMATION FOR SEQ ID NO: 91: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:91: GGCGGCCTGG AAA 13

(2) INFORMATION FOR SEQ ID NO: 92: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:92: GGCGGCCTGG AA 12

(2) INFORMATION FOR SEQ ID NO: 93: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 93: GGCGGCCTGG A 11

(2) INFORMATION FOR SEQ ID NO: 94: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (l ) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 94: GGCGGCCTGG 10 EPI-109 279

(2) INFORMATION FOR SEQ ID NO: 95: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 50 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 95: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAGGCTGGGC 50

(2) INFORMATION FOR SEQ ID NO: 96: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 49 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 96: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAGGCTGGG 49

(2) INFORMATION FOR SEQ ID NO: 97: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 48 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 97: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAGGCTGG 48

(2) INFORMATION FOR SEQ ID NO: 98:

(I) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 47 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(II) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 98: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAGGCTG 47

(2) INFORMATION FOR SEQ ID NO: 99:

(I) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 46 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(II) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 99: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAGGCT 46

(2) INFORMATION FOR SEQ ID NO: 100: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 45 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 100: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAGGC 45

(2) INFORMATION FOR SEQ ID NO: 101: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 44 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 101: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAGG 44

(2) INFORMATION FOR SEQ ID NO: 102: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 43 base pairs

(B) TYPE: nucleic acid EPI-109 280

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (11) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:102: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAG 43

(2) INFORMATION FOR SEQ ID NO: 103: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 42 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 103: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CA 42

(2) INFORMATION FOR SEQ ID NO: 104: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 41 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 104: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA C 41

(2) INFORMATION FOR SEQ ID NO: 105:

( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 40 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(II) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:105: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA 40

(2) INFORMATION FOR SEQ ID NO: 106: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 39 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 106: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGCGGGC 39

(2) INFORMATION FOR SEQ ID NO: 107: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 38 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 107: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGCGGG 38

(2) INFORMATION FOR SEQ ID NO: 108: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 37 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 108: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGCGG 37

(2) INFORMATION FOR SEQ ID NO: 109: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 36 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:109: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGCG 36 EPI-109 281

(2) INFORMATION FOR SEQ ID Nθ:110: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 35 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:110: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGC 35

(2) INFORMATION FOR SEQ ID NO: 111: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 111: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGG 34

(2) INFORMATION FOR SEQ ID NO:112: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 112: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATG 33

(2) INFORMATION FOR SEQ ID NO: 113:

(I) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(II) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 113: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC AT 32

(2) INFORMATION FOR SEQ ID NO: 114:

(I) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(II) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:114: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC A 31

(2) INFORMATION FOR SEQ ID NO: 115: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 115: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC 30

(2) INFORMATION FOR SEQ ID NO: 116:

(I) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(II) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 116: GCGGCCTGGA AAGCTGAGAT GGAGGGCGG 29

(2) INFORMATION FOR SEQ ID NO: 117: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid EPI-109 282

(C ) STRANDEDNESS : single

(D) TOPOLOGY: linear (11) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 117: GCGGCCTGGA AAGCTGAGAT GGAGGGCG 28

(2) INFORMATION FOR SEQ ID NO: 118: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 118: GCGGCCTGGA AAGCTGAGAT GGAGGGC 27

(2) INFORMATION FOR SEQ ID Nθ:119: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 119: GCGGCCTGGA AAGCTGAGAT GGAGGG 26

(2) INFORMATION FOR SEQ ID NO: 120: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:120: GCGGCCTGGA AAGCTGAGAT GGAGG 25

(2) INFORMATION FOR SEQ ID NO: 121: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 121: GCGGCCTGGA AAGCTGAGAT GGAG 24

(2) INFORMATION FOR SEQ ID NO: 122: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 122: GCGGCCTGGA AAGCTGAGAT GGA 23

(2) INFORMATION FOR SEQ ID NO: 123: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:123: GCGGCCTGGA AAGCTGAGAT GG 22

(2) INFORMATION FOR SEQ ID NO: 124: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 124: GCGGCCTGGA AAGCTGAGAT G 21 EPI-109 283

( 2 ) INFORMATION FOR SEQ ID NO : 125 :

(I) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(II) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 125: GCGGCCTGGA AAGCTGAGAT 20

(2) INFORMATION FOR SEQ ID NO: 126: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: Single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:126: GCGGCCTGGA AAGCTGAGA 19

(2) INFORMATION FOR SEQ ID NO: 127:

(I) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( I) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 127: GCGGCCTGGA AAGCTGAG 18

(2) INFORMATION FOR SEQ ID NO: 128: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 128: GCGGCCTGGA AAGCTGA 17

(2) INFORMATION FOR SEQ ID NO: 129: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:129: GCGGCCTGGA AAGCTG 16

(2) INFORMATION FOR SEQ ID NO: 130:

(I) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(II) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 130: GCGGCCTGGA AAGCT 15

(2) INFORMATION FOR SEQ ID NO: 131: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 131: GCGGCCTGGA AAGC 14

(2) INFORMATION FOR SEQ ID NO: 132: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid EPI-109 284

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (11) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 132: GCGGCCTGGA AAG 13

(2) INFORMATION FOR SEQ ID NO:133:

(I) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(II) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 133: GCGGCCTGGA AA 12

(2) INFORMATION FOR SEQ ID NO: 134: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li ) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:134: GCGGCCTGGA A 11

(2) INFORMATION FOR SEQ ID NO: 135: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:135: GCGGCCTGGA 10

(2) INFORMATION FOR SEQ ID NO:136: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 49 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 136: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AGGCTGGGC 49

(2) INFORMATION FOR SEQ ID NO: 137: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 48 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: Single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 137: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AGGCTGGG 48

(2) INFORMATION FOR SEQ ID NO: 138: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 47 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:138: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AGGCTGG 47

(2) INFORMATION FOR SEQ ID NO: 139: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 46 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 139: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AGGCTG 46 EPI-109 285

(2) INFORMATION FOR SEQ ID NO: 140: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 45 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 140: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AGGCT 45

(2) INFORMATION FOR SEQ ID NO: 141: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 44 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li ) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:141: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AGGC 44

(2) INFORMATION FOR SEQ ID NO: 142: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 43 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 142: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AGG 43

(2) INFORMATION FOR SEQ ID NO: 143: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 42 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 143: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AG 42

(2) INFORMATION FOR SEQ ID NO: 144: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 41 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 144: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGCGGGCAC A 41

(2) INFORMATION FOR SEQ ID NO:145: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 40 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 145: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGCGGGCAC 40

(2) INFORMATION FOR SEQ ID NO: 146: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 39 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 146: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGCGGGCA 39

(2) INFORMATION FOR SEQ ID NO: 147: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH. 38 base pairs

(B) TYPE: nucleic acid EPI-109 286

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (11) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:147: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGCGGGC 38

(2) INFORMATION FOR SEQ ID NO: 148: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 37 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 148: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGCGGG 37

(2) INFORMATION FOR SEQ ID NO: 149: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 36 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 149: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGCGG 36

(2) INFORMATION FOR SEQ ID NO: 150: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 35 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 150: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGCG 35

(2) INFORMATION FOR SEQ ID NO: 151: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 151: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGC 34

(2) INFORMATION FOR SEQ ID NO: 152: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:152: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGG 33

(2) INFORMATION FOR SEQ ID NO: 153:

(I) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(II) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 153: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TG 32

(2) INFORMATION FOR SEQ ID NO: 154: (1) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 154: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA T 31 EPI-109 287

(2) INFORMATION FOR SEQ ID NO: 155: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 155: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA 30

(2) INFORMATION FOR SEQ ID NO: 156: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 156: CGGCCTGGAA AGCTGAGATG GAGGGCGGC 29

(2) INFORMATION FOR SEQ ID NO: 157: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:157: CGGCCTGGAA AGCTGAGATG GAGGGCGG 28

(2) INFORMATION FOR SEQ ID NO: 158: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 158: CGGCCTGGAA AGCTGAGATG GAGGGCG 27

(2) INFORMATION FOR SEQ ID NO: 159: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 159: CGGCCTGGAA AGCTGAGATG GAGGGC 26

(2) INFORMATION FOR SEQ ID NO: 160: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 160: CGGCCTGGAA AGCTGAGATG GAGGG 25

(2) INFORMATION FOR SEQ ID NO: 161: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 161: CGGCCTGGAA AGCTGAGATG GAGG 24

(2) INFORMATION FOR SEQ ID NO: 162: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid EPI-109 288

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (11) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 162: CGGCCTGGAA AGCTGAGATG GAG 23

(2) INFORMATION FOR SEQ ID NO: 163: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 163: CGGCCTGGAA AGCTGAGATG GA 22

(2) INFORMATION FOR SEQ ID NO: 164: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 164: CGGCCTGGAA AGCTGAGATG G 21

(2) INFORMATION FOR SEQ ID NO: 165: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH. 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 165: CGGCCTGGAA AGCTGAGATG 20

(2) INFORMATION FOR SEQ ID NO: 166: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 166: CGGCCTGGAA AGCTGAGAT 19

(2) INFORMATION FOR SEQ ID NO: 167: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 167: CGGCCTGGAA AGCTGAGA 18

(2) INFORMATION FOR SEQ ID NO: 168: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:168: CGGCCTGGAA AGCTGAG 17

(2) INFORMATION FOR SEQ ID NO:169: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 169- CGGCCTGGAA AGCTGA 16 EPI-109 289

(2) INFORMATION FOR SEQ ID NO: 170: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 170: CGGCCTGGAA AGCTG 15

(2) INFORMATION FOR SEQ ID NO: 171: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 171: CGGCCTGGAA AGCT 14

(2) INFORMATION FOR SEQ ID NO: 172: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 172: CGGCCTGGAA AGC 13

(2) INFORMATION FOR SEQ ID NO:173: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 173: CGGCCTGGAA AG 12

(2) INFORMATION FOR SEQ ID NO: 174: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 174: CGGCCTGGAA A 11

(2) INFORMATION FOR SEQ ID NO:175: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 175: CGGCCTGGAA 10

(2) INFORMATION FOR SEQ ID NO: 176: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 48 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 176: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGCGGGCACA GGCTGGGC 48

(2) INFORMATION FOR SEQ ID NO: 177: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 47 base pairs

(B) TYPE: nucleic acid EPI-109 290

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (11) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:177: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGCGGGCACA GGCTGGG 47

(2) INFORMATION FOR SEQ ID NO: 178: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 46 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:178: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGCGGGCACA GGCTGG 46

(2) INFORMATION FOR SEQ ID NO: 179: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 45 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 179: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGCGGGCACA GGCTG 45

(2) INFORMATION FOR SEQ ID NO:180: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 44 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 180: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGCGGGCACA GGCT 44

(2) INFORMATION FOR SEQ ID NO: 181: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 43 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 181: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGCGGGCACA GGC 43

(2) INFORMATION FOR SEQ ID NO: 182: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 42 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 182: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGCGGGCACA GG 42

(2) INFORMATION FOR SEQ ID NO: 183: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 41 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:183: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGCGGGCACA G 41

(2) INFORMATION FOR SEQ ID NO: 184: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 40 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 184: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGCGGGCACA 40 EPI-109 291

( 2 ) INFORMATION FOR SEQ ID NO : 185 :

(I) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 39 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(II) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 185: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGCGGGCAC 39

(2) INFORMATION FOR SEQ ID NO: 186: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 38 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 186: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGCGGGCA 38

(2) INFORMATION FOR SEQ ID NO: 187:

(I) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 37 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(II) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 187: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGCGGGC 37

(2) INFORMATION FOR SEQ ID NO:188: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 36 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 188: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGCGGG 36

(2) INFORMATION FOR SEQ ID NO: 189: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 35 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS. Single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 189: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGCGG 35

(2) INFORMATION FOR SEQ ID NO: 190: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 190: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGCG 34

(2) INFORMATION FOR SEQ ID NO: 191: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 191: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGC 33

(2) INFORMATION FOR SEQ ID NO: 192: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid EPI-109 292

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (11) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:192: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GG 32

(2) INFORMATION FOR SEQ ID NO: 193: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 193: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT G 31

(2) INFORMATION FOR SEQ ID NO: 194: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 194: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT 30

(2) INFORMATION FOR SEQ ID NO: 195: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 195: GGCCTGGAAA GCTGAGATGG AGGGCGGCA 29

(2) INFORMATION FOR SEQ ID NO:196: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 196: GGCCTGGAAA GCTGAGATGG AGGGCGGC 28

(2) INFORMATION FOR SEQ ID NO: 197: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 197: GGCCTGGAAA GCTGAGATGG AGGGCGG 27

(2) INFORMATION FOR SEQ ID NO: 198: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 198: GGCCTGGAAA GCTGAGATGG AGGGCG 26

(2) INFORMATION FOR SEQ ID NO: 199:

(I) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(II) MOLECULE TYPE: cDNA

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 199: GGCCTGGAAA GCTGAGATGG AGGGC 25 EPI-109 293

(2) INFORMATION FOR SEQ ID NO:200: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:200: GGCCTGGAAA GCTGAGATGG AGGG 24

(2) INFORMATION FOR SEQ ID NO:201:

(I) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(II) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 201: GGCCTGGAAA GCTGAGATGG AGG 23

(2) INFORMATION FOR SEQ ID NO: 202: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:202: GGCCTGGAAA GCTGAGATGG AG 22

(2) INFORMATION FOR SEQ ID NO:203: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 203: GGCCTGGAAA GCTGAGATGG A 21

(2) INFORMATION FOR SEQ ID NO:204: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 204: GGCCTGGAAA GCTGAGATGG 20

(2) INFORMATION FOR SEQ ID NO: 205: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:205: GGCCTGGAAA GCTGAGATG 19

(2) INFORMATION FOR SEQ ID NO: 206: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 206: GGCCTGGAAA GCTGAGAT 18

(2) INFORMATION FOR SEQ ID NO:207: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid EPI-109 294

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (11) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:207: GGCCTGGAAA GCTGAGA 17

(2) INFORMATION FOR SEQ ID NO: 208: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:208: GGCCTGGAAA GCTGAG 16

(2) INFORMATION FOR SEQ ID NO: 209: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:209: GGCCTGGAAA GCTGA 15

(2) INFORMATION FOR SEQ ID NO:210: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 210: GGCCTGGAAA GCTG 14

(2) INFORMATION FOR SEQ ID NO:211: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

( i) SEQUENCE DESCRIPTION: SEQ ID NO:211: GGCCTGGAAA GCT 13

(2) INFORMATION FOR SEQ ID NO: 212:

(I) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 212: GGCCTGGAAA GC 12

(2) INFORMATION FOR SEQ ID NO: 213: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(II) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:213: GGCCTGGAAA G 11

(2) INFORMATION FOR SEQ ID NO: 214: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:214: GGCCTGGAAA 10 EPI-109 295

(2) INFORMATION FOR SEQ ID NO: 215: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 47 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:215: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GCGGGCACAG GCTGGGC 47

(2) INFORMATION FOR SEQ ID NO:216: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 46 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:216: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GCGGGCACAG GCTGGG 46

(2) INFORMATION FOR SEQ ID NO:217: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 45 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:217: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GCGGGCACAG GCTGG 45

(2) INFORMATION FOR SEQ ID NO:218: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 44 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 218: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GCGGGCACAG GCTG 44

(2) INFORMATION FOR SEQ ID NO:219: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 43 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:219: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GCGGGCACAG GCT 43

(2) INFORMATION FOR SEQ ID NO:220: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 42 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:220: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GCGGGCACAG GC 42

(2) INFORMATION FOR SEQ ID NO: 221: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH- 41 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 221: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GCGGGCACAG G 41

(2) INFORMATION FOR SEQ ID NO: 222: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 40 base pairs

(B) TYPE: nucleic acid EPI-109 296

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:222: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GCGGGCACAG 40

(2) INFORMATION FOR SEQ ID NO: 223: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 39 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: Single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(x ) SEQUENCE DESCRIPTION: SEQ ID NO: 223: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GCGGGCACA 39

(2) INFORMATION FOR SEQ ID NO:224: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 38 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:224: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GCGGGCAC 38

(2) INFORMATION FOR SEQ ID NO:225- (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 37 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:225: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GCGGGCA 37

(2) INFORMATION FOR SEQ ID NO: 226: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 36 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:226: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GCGGGC 36

(2) INFORMATION FOR SEQ ID NO: 227: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 35 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 227: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GCGGG 35

(2) INFORMATION FOR SEQ ID NO: 228: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:228: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GCGG 34

(2) INFORMATION FOR SEQ ID NO: 229:

(I) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(II) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:229: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GCG 33 EPI-109 297

(2) INFORMATION FOR SEQ ID NO: 230: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:230: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GC 32

(2) INFORMATION FOR SEQ ID NO: 231: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 231: GCCTGGAAAG CTGAGATGGA GGGCGGCATG G 31

(2) INFORMATION FOR SEQ ID NO:232. (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 232: GCCTGGAAAG CTGAGATGGA GGGCGGCATG 30

(2) INFORMATION FOR SEQ ID NO: 233: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:233: GCCTGGAAAG CTGAGATGGA GGGCGGCAT 29

(2) INFORMATION FOR SEQ ID NO:234: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 234: GCCTGGAAAG CTGAGATGGA GGGCGGCA 28

(2) INFORMATION FOR SEQ ID NO:235: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:235: GCCTGGAAAG CTGAGATGGA GGGCGGC 27

(2) INFORMATION FOR SEQ ID NO:236: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:236: GCCTGGAAAG CTGAGATGGA GGGCGG 26

(2) INFORMATION FOR SEQ ID NO: 237: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid EPI-109 298

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ll) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 237: GCCTGGAAAG CTGAGATGGA GGGCG 25

(2) INFORMATION FOR SEQ ID NO: 238: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:238: GCCTGGAAAG CTGAGATGGA GGGC 24

(2) INFORMATION FOR SEQ ID NO: 239: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:239: GCCTGGAAAG CTGAGATGGA GGG 23

(2) INFORMATION FOR SEQ ID NO: 240: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:240: GCCTGGAAAG CTGAGATGGA GG 22

(2) INFORMATION FOR SEQ ID NO: 241: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:241: GCCTGGAAAG CTGAGATGGA G 21

(2) INFORMATION FOR SEQ ID NO: 242:

(I) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: Single

(D) TOPOLOGY: linear

(II) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:242: GCCTGGAAAG CTGAGATGGA 20

(2) INFORMATION FOR SEQ ID NO:243:

(I) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(II) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:243: GCCTGGAAAG CTGAGATGG 19

(2) INFORMATION FOR SEQ ID NO: 244: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:244: GCCTGGAAAG CTGAGATG 18 EPI-109 ₂99

(2) INFORMATION FOR SEQ ID NO:245: (1) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 245: GCCTGGAAAG CTGAGAT 1

(21 INFORMATION FOR SEQ ID NO:246: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:246: GCCTGGAAAG CTGAGA 16

(2) INFORMATION FOR SEQ ID NO: 247: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:247: GCCTGGAAAG CTGAG 15

(2) INFORMATION FOR SEQ ID NO: 248: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:248: GCCTGGAAAG CTGA 14

(2) INFORMATION FOR SEQ ID NO: 2 9:

(I) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(II) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:249: GCCTGGAAAG CTG 13

(2) INFORMATION FOR SEQ ID NO:250: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 250: GCCTGGAAAG CT 12

(2) INFORMATION FOR SEQ ID NO:251: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:251: GCCTGGAAAG C 11

(2) INFORMATION FOR SEQ ID NO:252: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid EPI-109 300

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (11) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 252: GCCTGGAAAG 10

(2) INFORMATION FOR SEQ ID NO: 253: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 46 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:253: CCTGGAAAGC TGAGATGGAG GGCGGCATGG CGGGCACAGG CTGGGC 46

(2) INFORMATION FOR SEQ ID NO:254: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 45 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 254: CCTGGAAAGC TGAGATGGAG GGCGGCATGG CGGGCACAGG CTGGG 45

(2) INFORMATION FOR SEQ ID NO: 255. (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH 44 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:255: CCTGGAAAGC TGAGATGGAG GGCGGCATGG CGGGCACAGG CTGG 44

(2) INFORMATION FOR SEQ ID NO:256: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 43 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:256: CCTGGAAAGC TGAGATGGAG GGCGGCATGG CGGGCACAGG CTG 43

(2) INFORMATION FOR SEQ ID NO: 257: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 42 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:257: CCTGGAAAGC TGAGATGGAG GGCGGCATGG CGGGCACAGG CT 42

(2) INFORMATION FOR SEQ ID NO: 258: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 41 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 258: CCTGGAAAGC TGAGATGGAG GGCGGCATGG CGGGCACAGG C 41

(2) INFORMATION FOR SEQ ID NO:259:

(I) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 40 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(II) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:259- CCTGGAAAGC TGAGATGGAG GGCGGCATGG CGGGCACAGG 40 EPI-109 301

(2) INFORMATION FOR SEQ ID NO: 260: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 39 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:260: CCTGGAAAGC TGAGATGGAG GGCGGCATGG CGGGCACAG 39

(2) INFORMATION FOR SEQ ID NO: 261: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 38 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:261: CCTGGAAAGC TGAGATGGAG GGCGGCATGG CGGGCACA 38

(2) INFORMATION FOR SEQ ID NO: 262: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 37 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:262: CCTGGAAAGC TGAGATGGAG GGCGGCATGG CGGGCAC 37

(2) INFORMATION FOR SEQ ID NO: 263: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 36 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 263: CCTGGAAAGC TGAGATGGAG GGCGGCATGG CGGGCA 36

(2) INFORMATION FOR SEQ ID NO:264: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 35 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:264: CCTGGAAAGC TGAGATGGAG GGCGGCATGG CGGGC 35

(2) INFORMATION FOR SEQ ID NO: 265: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:265: CCTGGAAAGC TGAGATGGAG GGCGGCATGG CGGG 34

(2) INFORMATION FOR SEQ ID NO:266: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 266: CCTGGAAAGC TGAGATGGAG GGCGGCATGG CGG 33

(2) INFORMATION FOR SEQ ID NO: 267: (l) SEQUENCE CHARACTERISTICS: (A, LENGTH: 32 base pairs (B) TYPE: nucleic acid EPI-109 302

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (11) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:267: CCTGGAAAGC TGAGATGGAG GGCGGCATGG CG 32

(2) INFORMATION FOR SEQ ID NO: 268: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:268: CCTGGAAAGC TGAGATGGAG GGCGGCATGG C 31

(2) INFORMATION FOR SEQ ID NO:269: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:269: CCTGGAAAGC TGAGATGGAG GGCGGCATGG 30

(2) INFORMATION FOR SEQ ID NO:270: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:270: CCTGGAAAGC TGAGATGGAG GGCGGCATG 29

(2) INFORMATION FOR SEQ ID NO: 271: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 271: CCTGGAAAGC TGAGATGGAG GGCGGCAT 28

(2) INFORMATION FOR SEQ ID NO:272: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 272: CCTGGAAAGC TGAGATGGAG GGCGGCA 27

(2) INFORMATION FOR SEQ ID NO:273: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:273: CCTGGAAAGC TGAGATGGAG GGCGGC 26

(2) INFORMATION FOR SEQ ID NO:274: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 274: CCTGGAAAGC TGAGATGGAG GGCGG 25 EPI-109 303

(2) INFORMATION FOR SEQ ID NO:275: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:275: CCTGGAAAGC TGAGATGGAG GGCG 24

(2) INFORMATION FOR SEQ ID NO:276: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(x ) SEQUENCE DESCRIPTION: SEQ ID NO:276: CCTGGAAAGC TGAGATGGAG GGC 23

(2) INFORMATION FOR SEQ ID NO:277: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:277. CCTGGAAAGC TGAGATGGAG GG 22

(2) INFORMATION FOR SEQ ID NO:278: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:278: CCTGGAAAGC TGAGATGGAG G 21

(2) INFORMATION FOR SEQ ID NO: 279: (l) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 279: CCTGGAAAGC TGAGATGGAG 20

(2) INFORMATION FOR SEQ ID NO:280: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:280: CCTGGAAAGC TGAGATGGA 19

(2) INFORMATION FOR SEQ ID NO: 281: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:281: CCTGGAAAGC TGAGATGG 18

(2) INFORMATION FOR SEQ ID NO:282: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH 17 base pairs

(B) TYPE: nucleic acid EPI-109 304

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (11) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 282: CCTGGAAAGC TGAGATG 17

(2) INFORMATION FOR SEQ ID NO: 283: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 283: CCTGGAAAGC TGAGAT 16

(2) INFORMATION FOR SEQ ID NO: 284: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:284: CCTGGAAAGC TGAGA 15

(2) INFORMATION FOR SEQ ID NO: 285: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:285: CCTGGAAAGC TGAG 14

(2) INFORMATION FOR SEQ ID NO:286: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:286: CCTGGAAAGC TGA 13

(2) INFORMATION FOR SEQ ID NO:287:

(I) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(II) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:287: CCTGGAAAGC TG 12

(2) INFORMATION FOR SEQ ID NO: 288: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 288: CCTGGAAAGC T 11

(2) INFORMATION FOR SEQ ID NO: 289: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:289: CCTGGAAAGC 10 EPI-109 305

(2) INFORMATION FOR SEQ ID NO: 290: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 45 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:290: CTGGAAAGCT GAGATGGAGG GCGGCATGGC GGGCACAGGC TGGGC 45

(2) INFORMATION FOR SEQ ID NO: 291: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 44 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:291: CTGGAAAGCT GAGATGGAGG GCGGCATGGC GGGCACAGGC TGGG 44

(2) INFORMATION FOR SEQ ID NO: 292: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 43 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 292: CTGGAAAGCT GAGATGGAGG GCGGCATGGC GGGCACAGGC TGG 43

(2) INFORMATION FOR SEQ ID NO: 293: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 42 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:293: CTGGAAAGCT GAGATGGAGG GCGGCATGGC GGGCACAGGC TG 42

(2) INFORMATION FOR SEQ ID NO: 294: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 41 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 294: CTGGAAAGCT GAGATGGAGG GCGGCATGGC GGGCACAGGC T 41

(2) INFORMATION FOR SEQ ID NO: 295: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 40 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:295: CTGGAAAGCT GAGATGGAGG GCGGCATGGC GGGCACAGGC 40

(2) INFORMATION FOR SEQ ID NO: 296: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 39 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:296: CTGGAAAGCT GAGATGGAGG GCGGCATGGC GGGCACAGG 39

(2) INFORMATION FOR SEQ ID NO:297: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 38 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single EPI-109 306

(D) TOPOLOGY: linear (11) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:297: CTGGAAAGCT GAGATGGAGG GCGGCATGGC GGGCACAG 38

(2) INFORMATION FOR SEQ ID NO: 298: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 37 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (n) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 298: CTGGAAAGCT GAGATGGAGG GCGGCATGGC GGGCACA 37

(2) INFORMATION FOR SEQ ID NO:299: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 36 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:299: CTGGAAAGCT GAGATGGAGG GCGGCATGGC GGGCAC 36

(2) INFORMATION FOR SEQ ID NO:300: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 35 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:300: CTGGAAAGCT GAGATGGAGG GCGGCATGGC GGGCA 35

(2) INFORMATION FOR SEQ ID NO: 301: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 301: CTGGAAAGCT GAGATGGAGG GCGGCATGGC GGGC 34

(2) INFORMATION FOR SEQ ID NO:302: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 302: CTGGAAAGCT GAGATGGAGG GCGGCATGGC GGG 33

(2) INFORMATION FOR SEQ ID NO: 303: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:303: CTGGAAAGCT GAGATGGAGG GCGGCATGGC GG 32

(2) INFORMATION FOR SEQ ID NO: 304: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:304: CTGGAAAGCT GAGATGGAGG GCGGCATGGC G 31

(2) INFORMATION FOR SEQ ID NO: 305: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH. 30 base pairs

(B) TYPE: nucleic acid EPI-109 307

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 305: CTGGAAAGCT GAGATGGAGG GCGGCATGGC 30

(2) INFORMATION FOR SEQ ID NO:306: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:306: CTGGAAAGCT GAGATGGAGG GCGGCATGG 29

(2) INFORMATION FOR SEQ ID NO:307: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 307: CTGGAAAGCT GAGATGGAGG GCGGCATG 28

(2) INFORMATION FOR SEQ ID NO:308: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 308: CTGGAAAGCT GAGATGGAGG GCGGCAT 27

(2) INFORMATION FOR SEQ ID NO:309: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:309: CTGGAAAGCT GAGATGGAGG GCGGCA 26

(2) INFORMATION FOR SEQ ID NO: 310: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 310: CTGGAAAGCT GAGATGGAGG GCGGC 25

(2) INFORMATION FOR SEQ ID NO: 311: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 311: CTGGAAAGCT GAGATGGAGG GCGG 24

(2) INFORMATION FOR SEQ ID NO:312: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 312: CTGGAAAGCT GAGATGGAGG GCG 23

(2) INFORMATION FOR SEQ ID NO: 313: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 313. EPI-109 308

CTGGAAAGCT GAGATGGAGG GC 22

(2) INFORMATION FOR SEQ ID NO:314: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 314: CTGGAAAGCT GAGATGGAGG G 21

(2) INFORMATION FOR SEQ ID NO: 315: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: Single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:315: CTGGAAAGCT GAGATGGAGG 20

(2) INFORMATION FOR SEQ ID NO: 316: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 316: CTGGAAAGCT GAGATGGAG 19

(2) INFORMATION FOR SEQ ID NO:317: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:317: CTGGAAAGCT GAGATGGA 18

(2) INFORMATION FOR SEQ ID NO: 318: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 318: CTGGAAAGCT GAGATGG 17

(2) INFORMATION FOR SEQ ID NO:319: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 319: CTGGAAAGCT GAGATG 16

(2) INFORMATION FOR SEQ ID NO: 320: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 320: CTGGAAAGCT GAGAT 15

(2) INFORMATION FOR SEQ ID NO: 321: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:321: CTGGAAAGCT GAGA 14

(2) INFORMATION FOR SEQ ID NO: 322: EPI-109 309

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 322: CTGGAAAGCT GAG 13

(2) INFORMATION FOR SEQ ID NO: 323: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 323: CTGGAAAGCT GA 12

(2) INFORMATION FOR SEQ ID NO: 324: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 324: CTGGAAAGCT G 11

(2) INFORMATION FOR SEQ ID NO: 325: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 325: CTGGAAAGCT 10

(2) INFORMATION FOR SEQ ID NO: 326: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 44 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:326: TGGAAAGCTG AGATGGAGGG CGGCATGGCG GGCACAGGCT GGGC 44

(2) INFORMATION FOR SEQ ID NO:327: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 43 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 327: TGGAAAGCTG AGATGGAGGG CGGCATGGCG GGCACAGGCT GGG 43

(2) INFORMATION FOR SEQ ID NO: 328: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 42 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 328: TGGAAAGCTG AGATGGAGGG CGGCATGGCG GGCACAGGCT GG 42

(2) INFORMATION FOR SEQ ID NO: 329: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 41 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:329: TGGAAAGCTG AGATGGAGGG CGGCATGGCG GGCACAGGCT G 41

(2) INFORMATION FOR SEQ ID NO: 330: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 40 base pairs

(B) TYPE: nucleic acid EPI-109 310

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:330: TGGAAAGCTG AGATGGAGGG CGGCATGGCG GGCACAGGCT 40

(2) INFORMATION FOR SEQ ID NO: 331: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 39 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:331: TGGAAAGCTG AGATGGAGGG CGGCATGGCG GGCACAGGC 39

(2) INFORMATION FOR SEQ ID NO: 332: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 38 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 332: TGGAAAGCTG AGATGGAGGG CGGCATGGCG GGCACAGG 38

(2) INFORMATION FOR SEQ ID NO: 333: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 37 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:333: TGGAAAGCTG AGATGGAGGG CGGCATGGCG GGCACAG 37

(2) INFORMATION FOR SEQ ID NO: 334: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 36 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 334: TGGAAAGCTG AGATGGAGGG CGGCATGGCG GGCACA 36

(2) INFORMATION FOR SEQ ID NO: 335: (1) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 35 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(x ) SEQUENCE DESCRIPTION: SEQ ID NO:335: TGGAAAGCTG AGATGGAGGG CGGCATGGCG GGCAC 35

(2) INFORMATION FOR SEQ ID NO: 336: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:336: TGGAAAGCTG AGATGGAGGG CGGCATGGCG GGCA 34

(2) INFORMATION FOR SEQ ID NO: 337: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 337: TGGAAAGCTG AGATGGAGGG CGGCATGGCG GGC 33

(2) INFORMATION FOR SEQ ID NO: 338: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 338: EPI-109 311

TGGAAAGCTG AGATGGAGGG CGGCATGGCG GG 32

(2) INFORMATION FOR SEQ ID NO: 339: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 339: TGGAAAGCTG AGATGGAGGG CGGCATGGCG G 31

(2) INFORMATION FOR SEQ ID NO: 340: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:340: TGGAAAGCTG AGATGGAGGG CGGCATGGCG 30

(2) INFORMATION FOR SEQ ID NO:341: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 341: TGGAAAGCTG AGATGGAGGG CGGCATGGC 29

(2) INFORMATION FOR SEQ ID NO: 342: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 342: TGGAAAGCTG AGATGGAGGG CGGCATGG 28

(2) INFORMATION FOR SEQ ID NO: 343: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 343: TGGAAAGCTG AGATGGAGGG CGGCATG 27

(2) INFORMATION FOR SEQ ID NO: 344: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:344: TGGAAAGCTG AGATGGAGGG CGGCAT 26

(2) INFORMATION FOR SEQ ID NO: 345: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 345: TGGAAAGCTG AGATGGAGGG CGGCA 25

(2) INFORMATION FOR SEQ ID NO: 346: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:346: TGGAAAGCTG AGATGGAGGG CGGC 24

(2) INFORMATION FOR SEQ ID NO: 347: EPI-109 312

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 347: TGGAAAGCTG AGATGGAGGG CGG 23

(2) INFORMATION FOR SEQ ID NO: 348: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 348: TGGAAAGCTG AGATGGAGGG CG 22

(2) INFORMATION FOR SEQ ID NO: 349: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:349: TGGAAAGCTG AGATGGAGGG C 21

(2) INFORMATION FOR SEQ ID NO: 350: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 350: TGGAAAGCTG AGATGGAGGG 20

(2) INFORMATION FOR SEQ ID NO: 351: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 351: TGGAAAGCTG AGATGGAGG 19

(2) INFORMATION FOR SEQ ID NO: 352: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 352: TGGAAAGCTG AGATGGAG 18

(2) INFORMATION FOR SEQ ID NO: 353: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 353: TGGAAAGCTG AGATGGA 17

(2) INFORMATION FOR SEQ ID NO: 354: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:354: TGGAAAGCTG AGATGG 16

(2) INFORMATION FOR SEQ ID NO: 355: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid EPI-109 313

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 355: TGGAAAGCTG AGATG 15

(2) INFORMATION FOR SEQ ID NO: 356: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:356: TGGAAAGCTG AGAT 14

(2) INFORMATION FOR SEQ ID NO: 357: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 357: TGGAAAGCTG AGA 13

(2) INFORMATION FOR SEQ ID NO:358: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH. 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:358: TGGAAAGCTG AG 12

(2) INFORMATION FOR SEQ ID NO: 359: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:359: TGGAAAGCTG A 11

(2) INFORMATION FOR SEQ ID NO: 360: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 360: TGGAAAGCTG 10

(2) INFORMATION FOR SEQ ID NO: 361: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 43 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 361: GGAAAGCTGA GATGGAGGGC GGCATGGCGG GCACAGGCTG GGC 43

(2) INFORMATION FOR SEQ ID NO: 362: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 42 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 362: GGAAAGCTGA GATGGAGGGC GGCATGGCGG GCACAGGCTG GG 42

(2) INFORMATION FOR SEQ ID NO: 363: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 41 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:363: EPI-109 314

GGAAAGCTGA GATGGAGGGC GGCATGGCGG GCACAGGCTG G 41

(2) INFORMATION FOR SEQ ID NO: 364: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 40 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 364: GGAAAGCTGA GATGGAGGGC GGCATGGCGG GCACAGGCTG 40

(2) INFORMATION FOR SEQ ID NO: 365: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 39 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 365: GGAAAGCTGA GATGGAGGGC GGCATGGCGG GCACAGGCT 39

(2) INFORMATION FOR SEQ ID NO: 366: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 38 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: Single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 366: GGAAAGCTGA GATGGAGGGC GGCATGGCGG GCACAGGC 38

(2) INFORMATION FOR SEQ ID NO: 367: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 0 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 367:

(2) INFORMATION FOR SEQ ID NO: 368: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 36 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: Single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 368: GGAAAGCTGA GATGGAGGGC GGCATGGCGG GCACAG 36

(2) INFORMATION FOR SEQ ID NO:369: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 35 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: Single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:369: GGAAAGCTGA GATGGAGGGC GGCATGGCGG GCACA 35

(2) INFORMATION FOR SEQ ID NO: 370: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 370: GGAAAGCTGA GATGGAGGGC GGCATGGCGG GCAC 34

(2) INFORMATION FOR SEQ ID NO: 371: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:371: GGAAAGCTGA GATGGAGGGC GGCATGGCGG GCA 33

(2) INFORMATION FOR SEQ ID NO: 372: EPI-109 315

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 372: GGAAAGCTGA GATGGAGGGC GGCATGGCGG GC 32

(2) INFORMATION FOR SEQ ID NO: 373: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 373: GGAAAGCTGA GATGGAGGGC GGCATGGCGG G 31

(2) INFORMATION FOR SEQ ID NO: 374: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:374: GGAAAGCTGA GATGGAGGGC GGCATGGCGG 30

(2) INFORMATION FOR SEQ ID NO: 375: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:375: GGAAAGCTGA GATGGAGGGC GGCATGGCG 29

(2) INFORMATION FOR SEQ ID NO: 376: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 376: GGAAAGCTGA GATGGAGGGC GGCATGGC 28

(2) INFORMATION FOR SEQ ID NO: 377: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 377: GGAAAGCTGA GATGGAGGGC GGCATGG 27

(2) INFORMATION FOR SEQ ID NO: 378: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:378: GGAAAGCTGA GATGGAGGGC GGCATG 26

(2) INFORMATION FOR SEQ ID NO: 379: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 379: GGAAAGCTGA GATGGAGGGC GGCAT 25

(2) INFORMATION FOR SEQ ID NO: 380: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid EPI-109 316

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 380: GGAAAGCTGA GATGGAGGGC GGCA 24

(2) INFORMATION FOR SEQ ID NO: 381: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:381: GGAAAGCTGA GATGGAGGGC GGC 23

(2) INFORMATION FOR SEQ ID NO: 382: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:382: GGAAAGCTGA GATGGAGGGC GG 22

(2) INFORMATION FOR SEQ ID NO: 383: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:383: GGAAAGCTGA GATGGAGGGC G 21

(2) INFORMATION FOR SEQ ID NO: 384: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 384: GGAAAGCTGA GATGGAGGGC 20

(2) INFORMATION FOR SEQ ID NO: 385: (ι) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:385: GGAAAGCTGA GATGGAGGG 19

(2) INFORMATION FOR SEQ ID NO:386: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:386: GGAAAGCTGA GATGGAGG 18

(2) INFORMATION FOR SEQ ID NO: 387: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 387: GGAAAGCTGA GATGGAGG 18

(2) INFORMATION FOR SEQ ID NO: 388: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:388. EPI-109 317

GGAAAGCTGA GATGGA 16

(2) INFORMATION FOR SEQ ID NO: 389: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:389: GGAAAGCTGA GATGG 15

(2) INFORMATION FOR SEQ ID NO: 390: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:390: GGAAAGCTGA GATG 14

(2) INFORMATION FOR SEQ ID NO: 391: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:391: GGAAAGCTGA GAT 13

(2) INFORMATION FOR SEQ ID NO:392: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 392: GGAAAGCTGA GA 12

(2) INFORMATION FOR SEQ ID NO: 393: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 393: GGAAAGCTGA G 11

(2) INFORMATION FOR SEQ ID NO: 394: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 394: GGAAAGCTGA 10

(2) INFORMATION FOR SEQ ID NO: 395: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 42 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 395: GAAAGCTGAG ATGGAGGGCG GCATGGCGGG CACAGGCTGG GC 42

(2) INFORMATION FOR SEQ ID NO:396: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 41 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:396: GAAAGCTGAG ATGGAGGGCG GCATGGCGGG CACAGGCTGG G 41

(2) INFORMATION FOR SEQ ID NO: 397: EPI-109 318

( 1 ) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 40 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 397: GAAAGCTGAG ATGGAGGGCG GCATGGCGGG CACAGGCTGG 40

(2) INFORMATION FOR SEQ ID NO: 398: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 39 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 398: GAAAGCTGAG ATGGAGGGCG GCATGGCGGG CACAGGCTG 39

(2) INFORMATION FOR SEQ ID NO: 399: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 38 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO.-399: GAAAGCTGAG ATGGAGGGCG GCATGGCGGG CACAGGCT 38

(2) INFORMATION FOR SEQ ID NO: 400: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 37 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:400: GAAAGCTGAG ATGGAGGGCG GCATGGCGGG CACAGGC 37

(2) INFORMATION FOR SEQ ID NO: 401: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 36 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 401: GAAAGCTGAG ATGGAGGGCG GCATGGCGGG CACAGG 36

(2) INFORMATION FOR SEQ ID NO:402: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 35 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:402: GAAAGCTGAG ATGGAGGGCG GCATGGCGGG CACAG 35

(2) INFORMATION FOR SEQ ID NO: 403: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 403: GAAAGCTGAG ATGGAGGGCG GCATGGCGGG CACA 34

(2) INFORMATION FOR SEQ ID NO: 404: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 404: GAAAGCTGAG ATGGAGGGCG GCATGGCGGG CACA 34

(2) INFORMATION FOR SEQ ID NO: 05: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH. 32 base pairs

(B) TYPE: nucleic acid EPI-109 319

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 405: GAAAGCTGAG ATGGAGGGCG GCATGGCGGG CA 32

(2) INFORMATION FOR SEQ ID NO: 406: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 406: GAAAGCTGAG ATGGAGGGCG GCATGGCGGG C 31

(2) INFORMATION FOR SEQ ID NO: 07: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 07: GAAAGCTGAG ATGGAGGGCG GCATGGCGGG 30

(2) INFORMATION FOR SEQ ID NO: 408: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 408: GAAAGCTGAG ATGGAGGGCG GCATGGCGG 29

(2) INFORMATION FOR SEQ ID NO: 409: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:409: GAAAGCTGAG ATGGAGGGCG GCATGGCG 28

(2) INFORMATION FOR SEQ ID NO: 10: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:410: GAAAGCTGAG ATGGAGGGCG GCATGGC 27

(2) INFORMATION FOR SEQ ID NO: 411: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 411: GAAAGCTGAG ATGGAGGGCG GCATGG 26

(2) INFORMATION FOR SEQ ID NO: 412: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 412: GAAAGCTGAG ATGGAGGGCG GCATG 25

(2) INFORMATION FOR SEQ ID NO: 413: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 413: EPI-109 320

GAAAGCTGAG ATGGAGGGCG GCAT 24

(2) INFORMATION FOR SEQ ID NO: 414: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 414: GAAAGCTGAG ATGGAGGGCG GCA 23

(2) INFORMATION FOR SEQ ID NO: 415: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 415: GAAAGCTGAG ATGGAGGGCG GC 22

(2) INFORMATION FOR SEQ ID NO: 416: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS- single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 416: GAAAGCTGAG ATGGAGGGCG G 21

(2) INFORMATION FOR SEQ ID NO: 417: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 417: GAAAGCTGAG ATGGAGGGCG 20

(2) INFORMATION FOR SEQ ID NO: 418: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 418: GAAAGCTGAG ATGGAGGGC 19

(2) INFORMATION FOR SEQ ID NO: 419: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 419: GAAAGCTGAG ATGGAGGG 18

(2) INFORMATION FOR SEQ ID NO: 20: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:420: GAAAGCTGAG ATGGAGG 17

(2) INFORMATION FOR SEQ ID NO: 421: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:421: GAAAGCTGAG ATGGAG 16

(2) INFORMATION FOR SEQ ID NO:422: EPI-109 321

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 22: GAAAGCTGAG ATGGA 15

(2) INFORMATION FOR SEQ ID NO: 423: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 423: GAAAGCTGAG ATGG 14

(2) INFORMATION FOR SEQ ID NO: 424: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:424: GAAAGCTGAG ATG 13

(2) INFORMATION FOR SEQ ID NO: 425: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:425: GAAAGCTGAG AT 12

(2) INFORMATION FOR SEQ ID NO: 26: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 426: GAAAGCTGAG A 11

(2) INFORMATION FOR SEQ ID NO: 427: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 427: GAAAGCTGAG 10

(2) INFORMATION FOR SEQ ID NO: 28: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 41 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 428: AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGGCTGGG C 41

(2) INFORMATION FOR SEQ ID NO: 429: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 40 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 429: AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGGCTGGG 40

(2) INFORMATION FOR SEQ ID NO: 30: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 39 base pairs

(B) TYPE: nucleic acid EPI-109 322

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO-.430: AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGGCTGG 39

(2) INFORMATION FOR SEQ ID NO: 31: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 38 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:431: AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGGCTG 38

(2) INFORMATION FOR SEQ ID NO: 32: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 37 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 32: AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGGCT 37

(2) INFORMATION FOR SEQ ID NO: 433: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 36 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:433: AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGGC 36

(2) INFORMATION FOR SEQ ID NO: 434: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 35 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 434: AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGG 35

(2) INFORMATION FOR SEQ ID NO: 435: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 435: AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAG 34

(2) INFORMATION FOR SEQ ID NO: 36: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 436: AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACA 33

(2) INFORMATION FOR SEQ ID NO: 437: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 37: AAAGCTGAGA TGGAGGGCGG CATGGCGGGC AC 32

(2) INFORMATION FOR SEQ ID NO: 438: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 438: EPI-109 323

AAAGCTGAGA TGGAGGGCGG CATGGCGGGC A ₃1

(2) INFORMATION FOR SEQ ID NO: 439: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 439: AAAGCTGAGA TGGAGGGCGG CATGGCGGGC 30

(2) INFORMATION FOR SEQ ID NO: 440: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 40: AAAGCTGAGA TGGAGGGCGG CATGGCGGG 29

(2) INFORMATION FOR SEQ ID NO: 41: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 441: AAAGCTGAGA TGGAGGGCGG CATGGCGG 28

(2) INFORMATION FOR SEQ ID NO: 442: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:442: AAAGCTGAGA TGGAGGGCGG CATGGCG 27

(2) INFORMATION FOR SEQ ID NO: 443: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 443: AAAGCTGAGA TGGAGGGCGG CATGGC 26

(2) INFORMATION FOR SEQ ID NO: 444: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 444: AAAGCTGAGA TGGAGGGCGG CATGG 25

(2) INFORMATION FOR SEQ ID NO: 445: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 45: AAAGCTGAGA TGGAGGGCGG CATG 24

(2) INFORMATION FOR SEQ ID NO: 46: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 446: AAAGCTGAGA TGGAGGGCGG CAT 23

(2) INFORMATION FOR SEQ ID NO: 47: EPI-109 324

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 447: AAAGCTGAGA TGGAGGGCGG CA 22

(2) INFORMATION FOR SEQ ID NO: 448: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 448: AAAGCTGAGA TGGAGGGCGG C 21

(2) INFORMATION FOR SEQ ID NO: 449: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:449: AAAGCTGAGA TGGAGGGCGG 20

(2) INFORMATION FOR SEQ ID NO: 450: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 450: AAAGCTGAGA TGGAGGGCG 19

(2) INFORMATION FOR SEQ ID NO: 451: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:451: AAAGCTGAGA TGGAGGGC 18

(2) INFORMATION FOR SEQ ID NO: 52: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 452: AAAGCTGAGA TGGAGGG 17

(2) INFORMATION FOR SEQ ID NO: 453: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 453: AAAGCTGAGA TGGAGG 16

(2) INFORMATION FOR SEQ ID NO: 454: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 454: AAAGCTGAGA TGGAG 15

(2) INFORMATION FOR SEQ ID NO: 455: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid EPI-109 325

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 55: AAAGCTGAGA TGGA 14

(2) INFORMATION FOR SEQ ID NO: 456: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 456: AAAGCTGAGA TGG 13

(2) INFORMATION FOR SEQ ID NO: 457: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 457: AAAGCTGAGA TG 12

(2) INFORMATION FOR SEQ ID NO: 58: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 458: AAAGCTGAGA T 11

(2) INFORMATION FOR SEQ ID NO: 459: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 59: AAAGCTGAGA 10

(2) INFORMATION FOR SEQ ID NO: 60: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 40 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:460: AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAGGCTGGGC 40

(2) INFORMATION FOR SEQ ID NO: 61: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 39 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 61: AAAGCTGAGA T 11

(2) INFORMATION FOR SEQ ID NO: 462: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 38 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 462: AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAGGCTGG 38

(2) INFORMATION FOR SEQ ID NO: 463: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 37 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 463. EPI-109 326

AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAGGCTG 37

(2) INFORMATION FOR SEQ ID NO: 464: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 36 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 464: AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAGGCT 36

(2) INFORMATION FOR SEQ ID NO: 465: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 35 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:465: AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAGGC 35

(2) INFORMATION FOR SEQ ID NO: 66: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 466: AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAGG 34

(2) INFORMATION FOR SEQ ID NO: 467: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 467: AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAG 33

(2) INFORMATION FOR SEQ ID NO: 468: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:468: AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CA 32

(2) INFORMATION FOR SEQ ID NO: 469: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 469: AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA C 31

(2) INFORMATION FOR SEQ ID NO: 470: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 470: AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA 30

(2) INFORMATION FOR SEQ ID NO: 71: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 471: AAGCTGAGAT GGAGGGCGGC ATGGCGGGC 29

(2) INFORMATION FOR SEQ ID NO: 472: EPI-109 327

(1) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 472: AAGCTGAGAT GGAGGGCGGC ATGGCGGG 28

(2) INFORMATION FOR SEQ ID NO: 473: (l) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 473: AAGCTGAGAT GGAGGGCGGC ATGGCGG 27

(2) INFORMATION FOR SEQ ID NO: 474: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 474: AAGCTGAGAT GGAGGGCGGC ATGGCG 26

(2) INFORMATION FOR SEQ ID NO: 475: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 475: AAGCTGAGAT GGAGGGCGGC ATGGC 25

(2) INFORMATION FOR SEQ ID NO: 476: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 476: AAGCTGAGAT GGAGGGCGGC ATGG 24

(2) INFORMATION FOR SEQ ID NO: 477: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 477: AAGCTGAGAT GGAGGGCGGC ATG 23

(2) INFORMATION FOR SEQ ID NO: 78: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 78: AAGCTGAGAT GGAGGGCGGC AT 22

(2) INFORMATION FOR SEQ ID NO: 79: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 479: AAGCTGAGAT GGAGGGCGGC A 21

(2) INFORMATION FOR SEQ ID NO:480: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH. 20 base pairs

(B) TYPE: nucleic acid EPI-109 328

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:480: AAGCTGAGAT GGAGGGCGGC 20

(2) INFORMATION FOR SEQ ID NO: 481: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 481: AAGCTGAGAT GGAGGGCGG 19

(2) INFORMATION FOR SEQ ID NO: 482: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 482: AAGCTGAGAT GGAGGGCG 18

(2) INFORMATION FOR SEQ ID NO: 483: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 483: AAGCTGAGAT GGAGGGC 17

(2) INFORMATION FOR SEQ ID NO: 484: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 484: AAGCTGAGAT GGAGGG 16

(2) INFORMATION FOR SEQ ID NO: 485: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 485: AAGCTGAGAT GGAGG 15

(2) INFORMATION FOR SEQ ID NO: 486: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 486: AAGCTGAGAT GGAG 14

(2) INFORMATION FOR SEQ ID NO: 487: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 487: AAGCTGAGAT GGA 13

(2) INFORMATION FOR SEQ ID NO:488: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 488: EPI-109 329

AAGCTGAGAT GG 12

(2) INFORMATION FOR SEQ ID NO: 489: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 489: AAGCTGAGAT G 11

(2) INFORMATION FOR SEQ ID NO: 490: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 90: AAGCTGAGAT 10

(2) INFORMATION FOR SEQ ID NO: 491: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 39 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 491: AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AGGCTGGGC 39

(2) INFORMATION FOR SEQ ID NO: 492: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 38 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 492: AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AGGCTGGG 38

(2) INFORMATION FOR SEQ ID NO: 493: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 37 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 493: AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AGGCTGG 37

(2) INFORMATION FOR SEQ ID NO: 494: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 36 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 494: AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AGGCTG 36

(2) INFORMATION FOR SEQ ID NO: 495: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 35 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 495: AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AGGCT 35

(2) INFORMATION FOR SEQ ID NO: 496: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 496: AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AGGC 34

(2) INFORMATION FOR SEQ ID NO: 497: EPI-109 330

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 497: AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AGG 33

(2) INFORMATION FOR SEQ ID NO: 498: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 98: AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AG 32

(2) INFORMATION FOR SEQ ID NO:499: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 99: AGCTGAGATG GAGGGCGGCA TGGCGGGCAC A 31

(2) INFORMATION FOR SEQ ID NO: 500: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 500: AGCTGAGATG GAGGGCGGCA TGGCGGGCAC 30

(2) INFORMATION FOR SEQ ID NO: 501: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 501: AGCTGAGATG GAGGGCGGCA TGGCGGGCA 29

(2) INFORMATION FOR SEQ ID NO: 502: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 502: AGCTGAGATG GAGGGCGGCA TGGCGGGC 28

(2) INFORMATION FOR SEQ ID NO: 503: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 503: AGCTGAGATG GAGGGCGGCA TGGCGGG 27

(2) INFORMATION FOR SEQ ID NO: 504: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:504: AGCTGAGATG GAGGGCGGCA TGGCGG 26

(2) INFORMATION FOR SEQ ID NO: 505: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid EPI-109 331

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:505: AGCTGAGATG GAGGGCGGCA TGGCG 25

(2) INFORMATION FOR SEQ ID NO: 506: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 506: AGCTGAGATG GAGGGCGGCA TGGC 24

(2) INFORMATION FOR SEQ ID NO: 507: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 507: AGCTGAGATG GAGGGCGGCA TGG 23

(2) INFORMATION FOR SEQ ID NO: 508: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 508: AGCTGAGATG GAGGGCGGCA TG 22

(2) INFORMATION FOR SEQ ID NO: 509: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 509: AGCTGAGATG GAGGGCGGCA T 21

(2) INFORMATION FOR SEQ ID NO: 510: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS. single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:510: AGCTGAGATG GAGGGCGGCA 20

(2) INFORMATION FOR SEQ ID NO: 511: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:511: AGCTGAGATG GAGGGCGGC 19

(2) INFORMATION FOR SEQ ID NO: 512: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 512: AGCTGAGATG GAGGGCGG 18

(2) INFORMATION FOR SEQ ID NO:513: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 513: EPI-109 332

AGCTGAGATG GAGGGCG 17

(2) INFORMATION FOR SEQ ID NO: 514: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 514: AGCTGAGATG GAGGGC 16

(2) INFORMATION FOR SEQ ID NO: 515: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO.-515: AGCTGAGATG GAGGG 15

(2) INFORMATION FOR SEQ ID NO: 516: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 516: AGCTGAGATG GAGG 14

(2) INFORMATION FOR SEQ ID NO: 517: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 517: AGCTGAGATG GAG 13

(2) INFORMATION FOR SEQ ID NO:518: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:518: AGCTGAGATG GA 12

(2) INFORMATION FOR SEQ ID NO: 519: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 519: AGCTGAGATG G 11

(2) INFORMATION FOR SEQ ID NO: 520: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 520: AGCTGAGATG 10

(2) INFORMATION FOR SEQ ID NO:521: (1) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 38 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 521: GCTGAGATGG AGGGCGGCAT GGCGGGCACA GGCTGGGC 38

(2) INFORMATION FOR SEQ ID NO:522: EPI-109 333

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 37 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 522: GCTGAGATGG AGGGCGGCAT GGCGGGCACA GGCTGGG 37

(2) INFORMATION FOR SEQ ID NO: 523: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 36 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 523: GCTGAGATGG AGGGCGGCAT GGCGGGCACA GGCTGG 36

(2) INFORMATION FOR SEQ ID NO: 524: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 35 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 524: GCTGAGATGG AGGGCGGCAT GGCGGGCACA GGCTG 35

(2) INFORMATION FOR SEQ ID NO: 525: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 525: GCTGAGATGG AGGGCGGCAT GGCGGGCACA GGCT 34

(2) INFORMATION FOR SEQ ID NO: 526: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:526: GCTGAGATGG AGGGCGGCAT GGCGGGCACA GGC 33

(2) INFORMATION FOR SEQ ID NO: 527: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:527: GCTGAGATGG AGGGCGGCAT GGCGGGCACA GG 32

(2) INFORMATION FOR SEQ ID NO: 528: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:528: GCTGAGATGG AGGGCGGCAT GGCGGGCACA G 31

(2) INFORMATION FOR SEQ ID NO:529: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:529: GCTGAGATGG AGGGCGGCAT GGCGGGCACA 30

(2) INFORMATION FOR SEQ ID NO: 530: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid EPI-109 334

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 530: GCTGAGATGG AGGGCGGCAT GGCGGGCAC 29

(2) INFORMATION FOR SEQ ID NO: 531: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 531: GCTGAGATGG AGGGCGGCAT GGCGGGCA 28

(2) INFORMATION FOR SEQ ID NO: 532: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 532: GCTGAGATGG AGGGCGGCAT GGCGGGC 27

(2) INFORMATION FOR SEQ ID NO: 533: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:533: GCTGAGATGG AGGGCGGCAT GGCGGG 26

(2) INFORMATION FOR SEQ ID NO: 534: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 534: GCTGAGATGG AGGGCGGCAT GGCGG 25

(2) INFORMATION FOR SEQ ID NO: 535: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:535: GCTGAGATGG AGGGCGGCAT GGCG 24

(2) INFORMATION FOR SEQ ID NO: 536: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 536: GCTGAGATGG AGGGCGGCAT GGC 23

(2) INFORMATION FOR SEQ ID NO: 537: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 537: GCTGAGATGG AGGGCGGCAT GG 22

(2) INFORMATION FOR SEQ ID NO: 538: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 538: EPI-109 335

GCTGAGATGG AGGGCGGCAT G 21

(2) INFORMATION FOR SEQ ID NO: 539: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:539: GCTGAGATGG AGGGCGGCAT 20

(2) INFORMATION FOR SEQ ID NO: 540: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:540: GCTGAGATGG AGGGCGGCA 19

(2) INFORMATION FOR SEQ ID NO: 541: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:541: GCTGAGATGG AGGGCGGC 18

(2) INFORMATION FOR SEQ ID NO: 542: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:542: GCTGAGATGG AGGGCGG 17

(2) INFORMATION FOR SEQ ID NO: 543: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 543: GCTGAGATGG AGGGCG 16

(2) INFORMATION FOR SEQ ID NO: 544: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 544: GCTGAGATGG AGGGC 15

(2) INFORMATION FOR SEQ ID NO:545: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: Single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:545: GCTGAGATGG AGGG 14

(2) INFORMATION FOR SEQ ID NO: 546: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 546: GCTGAGATGG AGG 13

(2) INFORMATION FOR SEQ ID NO: 547: EPI-109 336

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 547: GCTGAGATGG AG 12

(2) INFORMATION FOR SEQ ID NO: 548: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 548: GCTGAGATGG A 11

(2) INFORMATION FOR SEQ ID NO: 549: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:549: GCTGAGATGG 10

(2) INFORMATION FOR SEQ ID NO: 550: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 37 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:550: CTGAGATGGA GGGCGGCATG GCGGGCACAG GCTGGGC 37

(2) INFORMATION FOR SEQ ID NO: 551: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 36 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 551: CTGAGATGGA GGGCGGCATG GCGGGCACAG GCTGGG 36

(2) INFORMATION FOR SEQ ID NO: 552: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 35 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:552: CTGAGATGGA GGGCGGCATG GCGGGCACAG GCTGG 35

(2) INFORMATION FOR SEQ ID NO: 553: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 553: CTGAGATGGA GGGCGGCATG GCGGGCACAG GCTG 34

(2) INFORMATION FOR SEQ ID NO: 554: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 554: CTGAGATGGA GGGCGGCATG GCGGGCACAG GCT 33

(2) INFORMATION FOR SEQ ID NO: 555: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid EPI-109 337

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 555: CTGAGATGGA GGGCGGCATG GCGGGCACAG GC 32

(2) INFORMATION FOR SEQ ID NO:556: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:556: CTGAGATGGA GGGCGGCATG GCGGGCACAG G 31

(2) INFORMATION FOR SEQ ID NO: 557: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 557: CTGAGATGGA GGGCGGCATG GCGGGCACAG 30

(2) INFORMATION FOR SEQ ID NO: 558: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 558: CTGAGATGGA GGGCGGCATG GCGGGCACA 29

(2) INFORMATION FOR SEQ ID NO:559: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:559: CTGAGATGGA GGGCGGCATG GCGGGCAC 28

(2) INFORMATION FOR SEQ ID NO: 560: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 560: CTGAGATGGA GGGCGGCATG GCGGGCA 27

(2) INFORMATION FOR SEQ ID NO: 561: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 561: CTGAGATGGA GGGCGGCATG GCGGGC 26

(2) INFORMATION FOR SEQ ID NO:562: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 562: CTGAGATGGA GGGCGGCATG GCGGG 25

(2) INFORMATION FOR SEQ ID NO: 563: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 563: EPI-109 338

CTGAGATGGA GGGCGGCATG GCGG 24

(2) INFORMATION FOR SEQ ID NO: 564: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 564: CTGAGATGGA GGGCGGCATG GCG 23

(2) INFORMATION FOR SEQ ID NO: 565: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 565: CTGAGATGGA GGGCGGCATG GC 22

(2) INFORMATION FOR SEQ ID NO: 566: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO-.566: CTGAGATGGA GGGCGGCATG G 21

(2) INFORMATION FOR SEQ ID NO:567: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:567: CTGAGATGGA GGGCGGCATG 20

(2) INFORMATION FOR SEQ ID NO: 568: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 568: CTGAGATGGA GGGCGGCAT 19

(2) INFORMATION FOR SEQ ID NO: 569: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:569: CTGAGATGGA GGGCGGCA 18

(2) INFORMATION FOR SEQ ID NO:570: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 570: CTGAGATGGA GGGCGGC 17

(2) INFORMATION FOR SEQ ID NO: 571: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:571: CTGAGATGGA GGGCGG 16

(2) INFORMATION FOR SEQ ID NO:572: EPI-109 339

(1) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 572: CTGAGATGGA GGGCG 15

(2) INFORMATION FOR SEQ ID NO: 573: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 573: CTGAGATGGA GGGC 14

(2) INFORMATION FOR SEQ ID NO: 574: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 574: CTGAGATGGA GGG 13

(2) INFORMATION FOR SEQ ID NO:575: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:575: CTGAGATGGA GG 12

(2) INFORMATION FOR SEQ ID NO: 576: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:576: CTGAGATGGA G 11

(2) INFORMATION FOR SEQ ID NO: 577: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 577: CTGAGATGGA 10

(2) INFORMATION FOR SEQ ID NO:578: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 36 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 578: TGAGATGGAG GGCGGCATGG CGGGCACAGG CTGGGC 36

(2) INFORMATION FOR SEQ ID NO: 579: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 35 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 579: TGAGATGGAG GGCGGCATGG CGGGCACAGG CTGGG 35

(2) INFORMATION FOR SEQ ID NO:580: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 base pairs

(B) TYPE: nucleic acid EPI-109 340

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:580: TGAGATGGAG GGCGGCATGG CGGGCACAGG CTGG 34

(2) INFORMATION FOR SEQ ID NO: 581: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 581: TGAGATGGAG GGCGGCATGG CGGGCACAGG CTG 33

(2) INFORMATION FOR SEQ ID NO: 582: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 582: TGAGATGGAG GGCGGCATGG CGGGCACAGG CT 32

(2) INFORMATION FOR SEQ ID NO: 583: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:583: TGAGATGGAG GGCGGCATGG CGGGCACAGG C 31

(2) INFORMATION FOR SEQ ID NO: 584: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 584: TGAGATGGAG GGCGGCATGG CGGGCACAGG 30

(2) INFORMATION FOR SEQ ID NO: 585: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 585: TGAGATGGAG GGCGGCATGG CGGGCACAG 29

(2) INFORMATION FOR SEQ ID NO: 586: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:586: TGAGATGGAG GGCGGCATGG CGGGCACA 28

(2) INFORMATION FOR SEQ ID NO: 587: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 587: TGAGATGGAG GGCGGCATGG CGGGCAC 27

(2) INFORMATION FOR SEQ ID NO:588: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 588: EPI-109 341

TGAGATGGAG GGCGGCATGG CGGGCA 26

(2) INFORMATION FOR SEQ ID NO: 589: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 589: TGAGATGGAG GGCGGCATGG CGGGC 25

(2) INFORMATION FOR SEQ ID NO: 590: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 590: TGAGATGGAG GGCGGCATGG CGGG 24

(2) INFORMATION FOR SEQ ID NO:591: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 591: TGAGATGGAG GGCGGCATGG CGG 23

(2) INFORMATION FOR SEQ ID NO: 592: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 592: TGAGATGGAG GGCGGCATGG CG 22

(2) INFORMATION FOR SEQ ID NO:593: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 593: TGAGATGGAG GGCGGCATGG C 21

(2) INFORMATION FOR SEQ ID NO:594: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 594: TGAGATGGAG GGCGGCATGG 20

(2) INFORMATION FOR SEQ ID NO: 595: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:595: TGAGATGGAG GGCGGCATG 19

(2) INFORMATION FOR SEQ ID NO.-596: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 596: TGAGATGGAG GGCGGCAT 18

(2) INFORMATION FOR SEQ ID NO: 597. EPI-109 342

(l) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:597: TGAGATGGAG GGCGGCA 17

(2) INFORMATION FOR SEQ ID NO: 598: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 598: TGAGATGGAG GGCGGC 16

(2) INFORMATION FOR SEQ ID NO: 599: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:599: TGAGATGGAG GGCGG 15

(2) INFORMATION FOR SEQ ID NO: 600: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 600: TGAGATGGAG GGCG 14

(2) INFORMATION FOR SEQ ID NO: 601: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 601: TGAGATGGAG GGC 13

(2) INFORMATION FOR SEQ ID NO: 602: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 602: TGAGATGGAG GG 12

(2) INFORMATION FOR SEQ ID NO: 603: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 603: TGAGATGGAG G 11

(2) INFORMATION FOR SEQ ID NO: 604: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 604: TGAGATGGAG 10

(2) INFORMATION FOR SEQ ID NO: 605: (l) SEQUENCE CHARACTERISTICS: (A; LENGTH: 35 base pairs (B) TYPE: nucleic acid EPI-109 343

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 605: GAGATGGAGG GCGGCATGGC GGGCACAGGC TGGGC 35

(2) INFORMATION FOR SEQ ID NO: 606: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(XI) SEQUENCE DESCRIPTION: SEQ ID NO: 606: GAGATGGAGG GCGGCATGGC GGGCACAGGC TGGG 34

(2) INFORMATION FOR SEQ ID NO: 607: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 607: GAGATGGAGG GCGGCATGGC GGGCACAGGC TGG 33

(2) INFORMATION FOR SEQ ID NO: 608: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 608: GAGATGGAGG GCGGCATGGC GGGCACAGGC TG 32

(2) INFORMATION FOR SEQ ID NO: 609: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 609: GAGATGGAGG GCGGCATGGC GGGCACAGGC T 31

(2) INFORMATION FOR SEQ ID NO: 610: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: Single

(D) TOPOLOGY: linear

(x ) SEQUENCE DESCRIPTION: SEQ ID NO:610: GAGATGGAGG GCGGCATGGC GGGCACAGG 29

(2) INFORMATION FOR SEQ ID NO: 611: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 611: GAGATGGAGG GCGGCATGGC GGGCACAGG 29

(2) INFORMATION FOR SEQ ID NO: 612: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 612: GAGATGGAGG GCGGCATGGC GGGCACAG 28

(2) INFORMATION FOR SEQ ID NO: 613: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 613: EPI-109 344

GAGATGGAGG GCGGCATGGC GGGCACA 27

(2) INFORMATION FOR SEQ ID NO: 614: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 614: GAGATGGAGG GCGGCATGGC GGGCAC 26

(2) INFORMATION FOR SEQ ID NO: 615: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 615: GAGATGGAGG GCGGCATGGC GGGCA 25

(2) INFORMATION FOR SEQ ID NO: 616: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 616: GAGATGGAGG GCGGCATGGC GGGC 24

(2) INFORMATION FOR SEQ ID NO: 617: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 617: GAGATGGAGG GCGGCATGGC GGG 23

(2) INFORMATION FOR SEQ ID NO: 618: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 618: GAGATGGAGG GCGGCATGGC GG 22

(2) INFORMATION FOR SEQ ID NO: 619: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 619: GAGATGGAGG GCGGCATGGC G 21

(2) INFORMATION FOR SEQ ID NO: 620: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 620: GAGATGGAGG GCGGCATGGC 20

(2) INFORMATION FOR SEQ ID NO: 621: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 621: GAGATGGAGG GCGGCATGG 19

(2) INFORMATION FOR SEQ ID NO: 622: EPI-109 345

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 622: GAGATGGAGG GCGGCATG 18

(2) INFORMATION FOR SEQ ID NO: 623: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 623: GAGATGGAGG GCGGCAT 17

(2) INFORMATION FOR SEQ ID NO: 624: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 624: GAGATGGAGG GCGGCA 16

(2) INFORMATION FOR SEQ ID NO: 625: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH. 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 625: GAGATGGAGG GCGGC 15

(2) INFORMATION FOR SEQ ID NO: 626: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 626: GAGATGGAGG GCGG 14

(2) INFORMATION FOR SEQ ID NO: 627: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH. 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 627: GAGATGGAGG GCG 13

(2) INFORMATION FOR SEQ ID NO: 628: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 628: GAGATGGAGG GC 12

(2) INFORMATION FOR SEQ ID NO: 629: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 629: GAGATGGAGG G 11

(2) INFORMATION FOR SEQ ID NO: 630: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid EPI-109 346

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 630: GAGATGGAGG 10

(2) INFORMATION FOR SEQ ID NO: 631: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 631: AGATGGAGGG CGGCATGGCG GGCACAGGCT GGGC 34

(2) INFORMATION FOR SEQ ID NO: 632: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 632: AGATGGAGGG CGGCATGGCG GGCACAGGCT GGG 33

(2) INFORMATION FOR SEQ ID NO: 633: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 633: AGATGGAGGG CGGCATGGCG GGCACAGGCT GG 32

(2) INFORMATION FOR SEQ ID NO: 634: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: Single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 634: AGATGGAGGG CGGCATGGCG GGCACAGGCT G 31

(2) INFORMATION FOR SEQ ID NO: 635: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 635: AGATGGAGGG CGGCATGGCG GGCACAGGCT 30

(2) INFORMATION FOR SEQ ID NO: 636: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 636: AGATGGAGGG CGGCATGGCG GGCACAGGC 29

(2) INFORMATION FOR SEQ ID NO: 637: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 637: AGATGGAGGG CGGCATGGCG GGCACAGG 28

(2) INFORMATION FOR SEQ ID NO: 638: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 638: EPI-109 347

AGATGGAGGG CGGCATGGCG GGCACAG 27

(2) INFORMATION FOR SEQ ID NO: 639: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 639: AGATGGAGGG CGGCATGGCG GGCACA 26

(2) INFORMATION FOR SEQ ID NO: 640: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 640: AGATGGAGGG CGGCATGGCG GGCAC 25

(2) INFORMATION FOR SEQ ID NO: 641: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 641: AGATGGAGGG CGGCATGGCG GGCA 24

(2) INFORMATION FOR SEQ ID NO: 642: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 642: AGATGGAGGG CGGCATGGCG GGC 23

(2) INFORMATION FOR SEQ ID NO: 643: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:643: AGATGGAGGG CGGCATGGCG GG 22

(2) INFORMATION FOR SEQ ID NO: 644: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 644: AGATGGAGGG CGGCATGGCG G 21

(2) INFORMATION FOR SEQ ID NO: 645: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 645: AGATGGAGGG CGGCATGGCG 20

(2) INFORMATION FOR SEQ ID NO: 646: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 646: AGATGGAGGG CGGCATGGC 19

(2) INFORMATION FOR SEQ ID NO: 647: EPI-109 348

( l ) SEQUENCE CHARACTERISTICS :

(A) LENGTH : 18 base pairs

(B ) TYPE : nucleic acid

(C ) STRANDEDNESS : single

( D) TOPOLOGY : linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 647: AGATGGAGGG CGGCATGG 18

(2) INFORMATION FOR SEQ ID NO: 648: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 648: AGATGGAGGG CGGCATG 17

(2) INFORMATION FOR SEQ ID NO: 649: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 649: AGATGGAGGG CGGCAT 16

(2) INFORMATION FOR SEQ ID NO: 650: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 650: AGATGGAGGG CGGCA 15

(2) INFORMATION FOR SEQ ID NO: 651: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 651: AGATGGAGGG CGGC 14

(2) INFORMATION FOR SEQ ID NO: 652: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 652: AGATGGAGGG CGG 13

(2) INFORMATION FOR SEQ ID NO: 653: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 653: AGATGGAGGG CG 12

(2) INFORMATION FOR SEQ ID NO: 654: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 654: AGATGGAGGG C 11

(2) INFORMATION FOR SEQ ID NO: 655: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid EPI-109 349

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 655: AGATGGAGGG 10

(2) INFORMATION FOR SEQ ID NO: 656: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 656: GATGGAGGGC GGCATGGCGG GCACAGGCTG GGC 33

(2) INFORMATION FOR SEQ ID NO: 657: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 657: GATGGAGGGC GGCATGGCGG GCACAGGCTG GG 32

(2) INFORMATION FOR SEQ ID NO: 658: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:658: GATGGAGGGC GGCATGGCGG GCACAGGCTG G 31

(2) INFORMATION FOR SEQ ID NO: 659: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 659: GATGGAGGGC GGCATGGCGG GCACAGGCTG 30

(2) INFORMATION FOR SEQ ID NO: 660: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:660: GATGGAGGGC GGCATGGCGG GCACAGGCT 29

(2) INFORMATION FOR SEQ ID NO:661: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 661: GATGGAGGGC GGCATGGCGG GCACAGGC 28

(2) INFORMATION FOR SEQ ID NO: 662: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 662: GATGGAGGGC GGCATGGCGG GCACAGG 27

(2) INFORMATION FOR SEQ ID NO: 663: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 663: EPI-109 350

GATGGAGGGC GGCATGGCGG GCACAG 26

(2) INFORMATION FOR SEQ ID NO: 664: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 664: GATGGAGGGC GGCATGGCGG GCACA 25

(2) INFORMATION FOR SEQ ID NO: 665: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 665: GATGGAGGGC GGCATGGCGG GCAC 24

(2) INFORMATION FOR SEQ ID NO: 666: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 666: GATGGAGGGC GGCATGGCGG GCA 23

(2) INFORMATION FOR SEQ ID NO: 667: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 667: GATGGAGGGC GGCATGGCGG GC 22

(2) INFORMATION FOR SEQ ID NO: 668: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 668: GATGGAGGGC GGCATGGCGG G 21

(2) INFORMATION FOR SEQ ID NO: 669: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 669: GATGGAGGGC GGCATGGCGG 20

(2) INFORMATION FOR SEQ ID NO: 670: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 670: GATGGAGGGC GGCATGGCG 19

(2) INFORMATION FOR SEQ ID NO: 671: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 671: GATGGAGGGC GGCATGGC 18

(2) INFORMATION FOR SEQ ID NO: 672: EPI-109 351

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:672: GATGGAGGGC GGCATGG 17

(2) INFORMATION FOR SEQ ID NO: 673: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:673: GATGGAGGGC GGCATG 16

(2) INFORMATION FOR SEQ ID NO: 674: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 674: GATGGAGGGC GGCAT 15

(2) INFORMATION FOR SEQ ID NO: 675: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 675: GATGGAGGGC GGCA 14

(2) INFORMATION FOR SEQ ID NO: 676: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 676: GATGGAGGGC GGC 13

(2) INFORMATION FOR SEQ ID NO: 677: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 677: GATGGAGGGC GG 12

(2) INFORMATION FOR SEQ ID NO: 678: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 678: GATGGAGGGC G 11

(2) INFORMATION FOR SEQ ID NO: 679: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 679: GATGGAGGGC 10

(2) INFORMATION FOR SEQ ID NO: 680: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid EPI-109 352

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 680: ATGGAGGGCG GCATGGCGGG CACAGGCTGG GC 32

(2) INFORMATION FOR SEQ ID NO: 681: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:681: ATGGAGGGCG GCATGGCGGG CACAGGCTGG G 31

(2) INFORMATION FOR SEQ ID NO: 682: d) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 682: ATGGAGGGCG GCATGGCGGG CACAGGCTGG 30

(2) INFORMATION FOR SEQ ID NO: 683: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 683: ATGGAGGGCG GCATGGCGGG CACAGGCTG 29

(2) INFORMATION FOR SEQ ID NO: 684: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 684: ATGGAGGGCG GCATGGCGGG CACAGGCT 28

(2) INFORMATION FOR SEQ ID NO: 685: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: Single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 685: ATGGAGGGCG GCATGGCGGG CACAGGC 27

(2) INFORMATION FOR SEQ ID NO: 686: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 686: ATGGAGGGCG GCATGGCGGG CACAGG 26

(2) INFORMATION FOR SEQ ID NO: 687: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 687: ATGGAGGGCG GCATGGCGGG CACAG 25

(2) INFORMATION FOR SEQ ID NO: 688: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 688: EPI-109 353

ATGGAGGGCG GCATGGCGGG CACA 24

(2) INFORMATION FOR SEQ ID NO: 689: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 689: ATGGAGGGCG GCATGGCGGG CAC 23

(2) INFORMATION FOR SEQ ID NO: 690: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 690: ATGGAGGGCG GCATGGCGGG CA 22

(2) INFORMATION FOR SEQ ID NO: 691: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 691: ATGGAGGGCG GCATGGCGGG C 21

(2) INFORMATION FOR SEQ ID NO: 692: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 692: ATGGAGGGCG GCATGGCGGG 20

(2) INFORMATION FOR SEQ ID NO: 693: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:693: ATGGAGGGCG GCATGGCGG 19

(2) INFORMATION FOR SEQ ID NO: 694: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 694: ATGGAGGGCG GCATGGCG 18

(2) INFORMATION FOR SEQ ID NO: 695: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 695: ATGGAGGGCG GCATGGC 17

(2) INFORMATION FOR SEQ ID NO: 696: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 696: ATGGAGGGCG GCATGG 16

(2) INFORMATION FOR SEQ ID NO: 697: EPI-109 354

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 697: ATGGAGGGCG GCATG 15

(2) INFORMATION FOR SEQ ID NO: 698: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 698: ATGGAGGGCG GCAT 14

(2) INFORMATION FOR SEQ ID NO: 699: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 699: ATGGAGGGCG GCA 13

(2) INFORMATION FOR SEQ ID NO:700: (1) SEQUENCE CHARACTERISTICS.

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:700: ATGGAGGGCG GC 12

(2) INFORMATION FOR SEQ ID NO: 701: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 701: ATGGAGGGCG G 11

(2) INFORMATION FOR SEQ ID NO: 702: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 702: ATGGAGGGCG 10

(2) INFORMATION FOR SEQ ID NO: 703: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:703: TGGAGGGCGG CATGGCGGGC ACAGGCTGGG C 31

(2) INFORMATION FOR SEQ ID NO: 704: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 704: TGGAGGGCGG CATGGCGGGC ACAGGCTGGG 30

(2) INFORMATION FOR SEQ ID NO:705: (l) SEQUENCE CHARACTERISTICS. (A, LENGTH: 29 base pairs (B) TYPE: nucleic acid EPI-109 355

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:705: TGGAGGGCGG CATGGCGGGC ACAGGCTGG 29

(2) INFORMATION FOR SEQ ID NO:706: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:706: TGGAGGGCGG CATGGCGGGC ACAGGCTG 28

(2) INFORMATION FOR SEQ ID NO: 707: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 707: TGGAGGGCGG CATGGCGGGC ACAGGCT 27

(2) INFORMATION FOR SEQ ID NO: 708: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:708: TGGAGGGCGG CATGGCGGGC ACAGGC 26

(2) INFORMATION FOR SEQ ID NO: 709: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:709: TGGAGGGCGG CATGGCGGGC ACAGG 25

(2) INFORMATION FOR SEQ ID NO: 710: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:710: TGGAGGGCGG CATGGCGGGC ACAG 24

(2) INFORMATION FOR SEQ ID NO: 711: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 711: TGGAGGGCGG CATGGCGGGC ACA 23

(2) INFORMATION FOR SEQ ID NO:712: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 712: TGGAGGGCGG CATGGCGGGC AC 22

(2) INFORMATION FOR SEQ ID NO: 713: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:713: EPI-109 356

TGGAGGGCGG CATGGCGGGC A 21

(2) INFORMATION FOR SEQ ID NO: 714: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 714: TGGAGGGCGG CATGGCGGGC 20

(2) INFORMATION FOR SEQ ID NO:715: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:715: TGGAGGGCGG CATGGCGGG 19

(2) INFORMATION FOR SEQ ID NO: 716: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 716: TGGAGGGCGG CATGGCGG 18

(2) INFORMATION FOR SEQ ID NO: 717: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 717: TGGAGGGCGG CATGGCG 17

(2) INFORMATION FOR SEQ ID NO: 718: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 718: TGGAGGGCGG CATGGC 16

(2) INFORMATION FOR SEQ ID NO: 719: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:719: TGGAGGGCGG CATGG 15

(2) INFORMATION FOR SEQ ID NO: 720: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:720: TGGAGGGCGG CATG 14

(2) INFORMATION FOR SEQ ID NO: 721: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 721: TGGAGGGCGG CAT 13

(2) INFORMATION FOR SEQ ID NO:722: EPI-109 357

(1) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 722: TGGAGGGCGG CA 12

(2) INFORMATION FOR SEQ ID NO: 723: (l) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:723: TGGAGGGCGG C 11

(2) INFORMATION FOR SEQ ID NO: 724: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:724: TGGAGGGCGG 10

(2) INFORMATION FOR SEQ ID NO:725: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 725: GGAGGGCGGC ATGGCGGGCA CAGGCTGGGC 30

(2) INFORMATION FOR SEQ ID NO: 726: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:726: GGAGGGCGGC ATGGCGGGCA CAGGCTGGG 29

(2) INFORMATION FOR SEQ ID NO: 727: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 727: GGAGGGCGGC ATGGCGGGCA CAGGCTGG 28

(2) INFORMATION FOR SEQ ID NO: 728: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:728: GGAGGGCGGC ATGGCGGGCA CAGGCTG 27

(2) INFORMATION FOR SEQ ID NO: 729: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 729: GGAGGGCGGC ATGGCGGGCA CAGGCT 26

(2) INFORMATION FOR SEQ ID NO: 730: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid EPI-109 358

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:730: GGAGGGCGGC ATGGCGGGCA CAGGC 25

(2) INFORMATION FOR SEQ ID NO: 731: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 731: GGAGGGCGGC ATGGCGGGCA CAGG 24

(2) INFORMATION FOR SEQ ID NO: 732: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 732: GGAGGGCGGC ATGGCGGGCA CAG 23

(2) INFORMATION FOR SEQ ID NO: 733: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 733: GGAGGGCGGC ATGGCGGGCA CA 22

(2) INFORMATION FOR SEQ ID NO: 734: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 734: GGAGGGCGGC ATGGCGGGCA C 21

(2) INFORMATION FOR SEQ ID NO: 735: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 735: GGAGGGCGGC ATGGCGGGCA 20

(2) INFORMATION FOR SEQ ID NO: 736: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 736: GGAGGGCGGC ATGGCGGGC 19

(2) INFORMATION FOR SEQ ID NO: 737: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:737: GGAGGGCGGC ATGGCGGG 18

(2) INFORMATION FOR SEQ ID NO: 738: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 738- EPI-109 359

GGAGGGCGGC ATGGCGG 17

(2) INFORMATION FOR SEQ ID NO:739: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 739: GGAGGGCGGC ATGGCG 16

(2) INFORMATION FOR SEQ ID NO: 740: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 740: GGAGGGCGGC ATGGC 15

(2) INFORMATION FOR SEQ ID NO:741: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 741: GGAGGGCGGC ATGG 14

(2) INFORMATION FOR SEQ ID NO: 742: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:742: GGAGGGCGGC ATG 13

(2) INFORMATION FOR SEQ ID NO: 743: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 743: GGAGGGCGGC AT 12

(2) INFORMATION FOR SEQ ID NO: 744: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:744: GGAGGGCGGC A 11

(2) INFORMATION FOR SEQ ID NO: 745: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:745: GGAGGGCGGC 10

(2) INFORMATION FOR SEQ ID NO:746: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 746: GAGGGCGGCA TGGCGGGCAC AGGCTGGGC 29

(2) INFORMATION FOR SEQ ID NO: 747: EPI-109 360

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:747: GAGGGCGGCA TGGCGGGCAC AGGCTGGG 28

(2) INFORMATION FOR SEQ ID NO: 748: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 748: GAGGGCGGCA TGGCGGGCAC AGGCTGG 27

(2) INFORMATION FOR SEQ ID NO: 749: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:749: GAGGGCGGCA TGGCGGGCAC AGGCTG 26

(2) INFORMATION FOR SEQ ID NO:750: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 750: GAGGGCGGCA TGGCGGGCAC AGGCT 25

(2) INFORMATION FOR SEQ ID NO: 751: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 751: GAGGGCGGCA TGGCGGGCAC AGGC 24

(2) INFORMATION FOR SEQ ID NO: 752: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 752: GAGGGCGGCA TGGCGGGCAC AGG 23

(2) INFORMATION FOR SEQ ID NO: 753: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 753: GAGGGCGGCA TGGCGGGCAC AG 22

(2) INFORMATION FOR SEQ ID NO:754: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 754: GAGGGCGGCA TGGCGGGCAC A 21

(2) INFORMATION FOR SEQ ID NO: 755: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid EPI-109 361

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:755: GAGGGCGGCA TGGCGGGCAC 20

(2) INFORMATION FOR SEQ ID NO: 756: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 756: GAGGGCGGCA TGGCGGGCA 19

(2) INFORMATION FOR SEQ ID NO: 757: (l) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 757: GAGGGCGGCA TGGCGGGC 18

(2) INFORMATION FOR SEQ ID NO: 758: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:758: GAGGGCGGCA TGGCGGG 17

(2) INFORMATION FOR SEQ ID NO:759: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 759: GAGGGCGGCA TGGCGG 16

(2) INFORMATION FOR SEQ ID NO: 760: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:760: GAGGGCGGCA TGGCG 15

(2) INFORMATION FOR SEQ ID NO:761: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:761: GAGGGCGGCA TGGC 14

(2) INFORMATION FOR SEQ ID NO: 762: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 762: GAGGGCGGCA TGG 13

(2) INFORMATION FOR SEQ ID NO: 763: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 763: EPI-109 362

GAGGGCGGCA TG 12

(2) INFORMATION FOR SEQ ID NO: 764: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 764:

GAGGGCGGCA T 11

(2) INFORMATION FOR SEQ ID NO: 765: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:765: GAGGGCGGCA 10

(2) INFORMATION FOR SEQ ID NO: 766: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:766: AGGGCGGCAT GGCGGGCACA GGCTGGGC 28

(2) INFORMATION FOR SEQ ID NO:767: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 767: AGGGCGGCAT GGCGGGCACA GGCTGGG 27

(2) INFORMATION FOR SEQ ID NO: 768: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 768: AGGGCGGCAT GGCGGGCACA GGCTGG 26

(2) INFORMATION FOR SEQ ID NO: 769: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:769: AGGGCGGCAT GGCGGGCACA GGCTG 25

(2) INFORMATION FOR SEQ ID NO: 770: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:770: AGGGCGGCAT GGCGGGCACA GGCT 24

(2) INFORMATION FOR SEQ ID NO: 771: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:771: AGGGCGGCAT GGCGGGCACA GGC 23

(2) INFORMATION FOR SEQ ID NO: 772: EPI-109 363

(1) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 772: AGGGCGGCAT GGCGGGCACA GG 22

(2) INFORMATION FOR SEQ ID NO: 773: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 773: AGGGCGGCAT GGCGGGCACA G 21

(2) INFORMATION FOR SEQ ID NO: 774: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 774: AGGGCGGCAT GGCGGGCACA 20

(2) INFORMATION FOR SEQ ID NO:775: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:775: AGGGCGGCAT GGCGGGCAC 19

(2) INFORMATION FOR SEQ ID NO: 776: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:776: AGGGCGGCAT GGCGGGCA 18

(2) INFORMATION FOR SEQ ID NO:777: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 777: AGGGCGGCAT GGCGGGC 17

(2) INFORMATION FOR SEQ ID NO:778: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 778: AGGGCGGCAT GGCGGG 16

(2) INFORMATION FOR SEQ ID NO: 779: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:779: AGGGCGGCAT GGCGG 15

(2) INFORMATION FOR SEQ ID NO: 780: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid EPI-109 364

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:780: AGGGCGGCAT GGCG 14

(2) INFORMATION FOR SEQ ID NO: 781: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:781: AGGGCGGCAT GGC 13

(2) INFORMATION FOR SEQ ID NO: 782: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 782: AGGGCGGCAT GG 12

(2) INFORMATION FOR SEQ ID NO: 783: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 783: AGGGCGGCAT G 11

(2) INFORMATION FOR SEQ ID NO: 784: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:784: AGGGCGGCAT 10

(2) INFORMATION FOR SEQ ID NO: 785: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:785: GGGCGGCATG GCGGGCACAG GCTGGGC 27

(2) INFORMATION FOR SEQ ID NO:786: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 786: GGGCGGCATG GCGGGCACAG GCTGGG 26

(2) INFORMATION FOR SEQ ID NO.-787: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 787: GGGCGGCATG GCGGGCACAG GCTGG 25

(2) INFORMATION FOR SEQ ID NO: 788: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 788: EPI-109 365

GGGCGGCATG GCGGGCACAG GCTG 24

(2) INFORMATION FOR SEQ ID NO: 789: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO:789: GGGCGGCATG GCGGGCACAG GCT 23

(2) INFORMATION FOR SEQ ID NO: 790: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:790: GGGCGGCATG GCGGGCACAG GC 22

(2) INFORMATION FOR SEQ ID NO: 791: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 791: GGGCGGCATG GCGGGCACAG G 21

(2) INFORMATION FOR SEQ ID NO: 792: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 792: GGGCGGCATG GCGGGCACAG 20

(2) INFORMATION FOR SEQ ID NO: 793: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 793: GGGCGGCATG GCGGGCACA 19

(2) INFORMATION FOR SEQ ID NO: 794: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 794: GGGCGGCATG GCGGGCAC 18

(2) INFORMATION FOR SEQ ID NO:795: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:795: GGGCGGCATG GCGGGCA 17

(2) INFORMATION FOR SEQ ID NO: 796: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:796: GGGCGGCATG GCGGGC 16

(2) INFORMATION FOR SEQ ID NO: 797: EPI-109 366

(1) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:797: GGGCGGCATG GCGGG 15

(2) INFORMATION FOR SEQ ID NO:798: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 798: GGGCGGCATG GCGG 14

(2) INFORMATION FOR SEQ ID NO: 799: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:799: GGGCGGCATG GCG 13

(2) INFORMATION FOR SEQ ID NO: 800: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:800: GGGCGGCATG GC 12

(2) INFORMATION FOR SEQ ID NO: 801: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 801: GGGCGGCATG G 11

(2) INFORMATION FOR SEQ ID NO:802: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 802: GGGCGGCATG 10

(2) INFORMATION FOR SEQ ID NO: 803: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 803: GGCGGCATGG CGGGCACAGG CTGGGC 26

(2) INFORMATION FOR SEQ ID NO: 804: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 804: GGCGGCATGG CGGGCACAGG CTGGG 25

(2) INFORMATION FOR SEQ ID NO:805: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid EPI-109 367

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 805: GGCGGCATGG CGGGCACAGG CTGG 24

(2) INFORMATION FOR SEQ ID NO: 806: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 806: GGCGGCATGG CGGGCACAGG CTG 23

(2) INFORMATION FOR SEQ ID NO: 807: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 807: GGCGGCATGG CGGGCACAGG CT 22

(2) INFORMATION FOR SEQ ID NO: 808: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 808: GGCGGCATGG CGGGCACAGG C 21

(2) INFORMATION FOR SEQ ID NO: 809: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:809: GGCGGCATGG CGGGCACAGG 20

(2) INFORMATION FOR SEQ ID NO: 810: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:810: GGCGGCATGG CGGGCACAG 19

(2) INFORMATION FOR SEQ ID NO: 811: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 811: GGCGGCATGG CGGGCACA 18

(2) INFORMATION FOR SEQ ID NO: 812: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 812: GGCGGCATGG CGGGCAC 17

(2) INFORMATION FOR SEQ ID NO: 813: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 813: EPI-109 368

GGCGGCATGG CGGGCA 16

(2) INFORMATION FOR SEQ ID NO: 814: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 814: GGCGGCATGG CGGGC 15

(2) INFORMATION FOR SEQ ID NO:815: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 815: GGCGGCATGG CGGG 14

(2) INFORMATION FOR SEQ ID NO.-816: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 816: GGCGGCATGG CGG 13

(2) INFORMATION FOR SEQ ID NO: 817: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 817: GGCGGCATGG CG 12

(2) INFORMATION FOR SEQ ID NO: 818: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 818: GGCGGCATGG C 11

(2) INFORMATION FOR SEQ ID NO: 819: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 819: GGCGGCATGG 10

(2) INFORMATION FOR SEQ ID NO:820: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 820: GCGGCATGGC GGGCACAGGC TGGGC 25

(2) INFORMATION FOR SEQ ID NO: 821: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 821: GCGGCATGGC GGGCACAGGC TGGG 24

(2) INFORMATION FOR SEQ ID NO: 822: EPI-109 369

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 822: GCGGCATGGC GGGCACAGGC TGG 23

(2) INFORMATION FOR SEQ ID NO: 823: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 823: GCGGCATGGC GGGCACAGGC TG 22

(2) INFORMATION FOR SEQ ID NO: 824: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 824: GCGGCATGGC GGGCACAGGC T 21

(2) INFORMATION FOR SEQ ID NO: 825: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:825: GCGGCATGGC GGGCACAGGC 20

(2) INFORMATION FOR SEQ ID NO: 826: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 826: GCGGCATGGC GGGCACAGG 19

(2) INFORMATION FOR SEQ ID NO: 827: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 827: GCGGCATGGC GGGCACAG 18

(2) INFORMATION FOR SEQ ID NO: 828: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 828: GCGGCATGGC GGGCACA 17

(2) INFORMATION FOR SEQ ID NO:829: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 829: GCGGCATGGC GGGCAC 16

(2) INFORMATION FOR SEQ ID NO: 830: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid EPI-109 370

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 830: GCGGCATGGC GGGCA 15

(2) INFORMATION FOR SEQ ID NO: 831: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 831: GCGGCATGGC GGGC 14

(2) INFORMATION FOR SEQ ID NO: 832: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 832: GCGGCATGGC GGG 13

(2) INFORMATION FOR SEQ ID NO: 833: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 833: GCGGCATGGC GG 12

(2) INFORMATION FOR SEQ ID NO: 834: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 834: GCGGCATGGC G 11

(2) INFORMATION FOR SEQ ID NO: 835: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 835: GCGGCATGGC 10

(2) INFORMATION FOR SEQ ID NO:836: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 836: CGGCATGGCG GGCACAGGCT GGGC 24

(2) INFORMATION FOR SEQ ID NO: 837: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 837: CGGCATGGCG GGCACAGGCT GGG 23

(2) INFORMATION FOR SEQ ID NO: 838: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 838: EPI-109 371

CGGCATGGCG GGCACAGGCT GG 22

(2) INFORMATION FOR SEQ ID NO: 839: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 839: CGGCATGGCG GGCACAGGCT G 21

(2) INFORMATION FOR SEQ ID NO: 840: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 840: CGGCATGGCG GGCACAGGCT 20

(2) INFORMATION FOR SEQ ID NO: 841: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:841: CGGCATGGCG GGCACAGGC 19

(2) INFORMATION FOR SEQ ID NO: 842: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 842: CGGCATGGCG GGCACAGG 18

(2) INFORMATION FOR SEQ ID NO:843: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 843: CGGCATGGCG GGCACAG 17

(2) INFORMATION FOR SEQ ID NO: 844: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 844: CGGCATGGCG GGCACA 16

(2) INFORMATION FOR SEQ ID NO: 845: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 845: CGGCATGGCG GGCAC 15

(2) INFORMATION FOR SEQ ID NO: 846: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:846: CGGCATGGCG GGCA 14

(2) INFORMATION FOR SEQ ID NO: 847: EPI-109 372

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 847: CGGCATGGCG GGC 13

(2) INFORMATION FOR SEQ ID NO: 848: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 848: CGGCATGGCG GG 12

(2) INFORMATION FOR SEQ ID NO: 849: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:849: CGGCATGGCG G 11

(2) INFORMATION FOR SEQ ID NO:850: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:850: CGGCATGGCG 10

(2) INFORMATION FOR SEQ ID NO: 851: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 851: GGCATGGCGG GCACAGGCTG GGC 23

(2) INFORMATION FOR SEQ ID NO: 852: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 852: GGCATGGCGG GCACAGGCTG GG 22

(2) INFORMATION FOR SEQ ID NO: 853: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: Single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:853: GGCATGGCGG GCACAGGCTG G 21

(2) INFORMATION FOR SEQ ID NO: 854: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 854: GGCATGGCGG GCACAGGCTG 20

(2) INFORMATION FOR SEQ ID NO: 855: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid EPI-109 373

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:855: GGCATGGCGG GCACAGGCT 19

(2) INFORMATION FOR SEQ ID NO:856: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:856: GGCATGGCGG GCACAGGC 18

(2) INFORMATION FOR SEQ ID NO: 857: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 857: GGCATGGCGG GCACAGG 17

(2) INFORMATION FOR SEQ ID NO: 858: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:858: GGCATGGCGG GCACAG 16

(2) INFORMATION FOR SEQ ID NO: 859: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:859: GGCATGGCGG GCACA 15

(2) INFORMATION FOR SEQ ID NO: 860: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 860: GGCATGGCGG GCAC 14

(2) INFORMATION FOR SEQ ID NO: 861: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 861: GGCATGGCGG GCA 13

(2) INFORMATION FOR SEQ ID NO:862: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 862: GGCATGGCGG GC 12

(2) INFORMATION FOR SEQ ID NO: 863: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 863: EPI-109 374

GGCATGGCGG G 11

(2) INFORMATION FOR SEQ ID NO:864: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 864: GGCATGGCGG 10

(2) INFORMATION FOR SEQ ID NO: 865: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 865: GCATGGCGGG CACAGGCTGG GC 22

(2) INFORMATION FOR SEQ ID NO: 866: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: Single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 866: GCATGGCGGG CACAGGCTGG G 21

(2) INFORMATION FOR SEQ ID NO: 867: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:867: GCATGGCGGG CACAGGCTGG 20

(2) INFORMATION FOR SEQ ID NO: 868: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 868: GCATGGCGGG CACAGGCTG 19

(2) INFORMATION FOR SEQ ID NO: 869: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:869: GCATGGCGGG CACAGGCT 18

(2) INFORMATION FOR SEQ ID NO:870: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 870: GCATGGCGGG CACAGGC 17

(2) INFORMATION FOR SEQ ID NO: 871: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 871: GCATGGCGGG CACAGG 16

(2) INFORMATION FOR SEQ ID NO:872: EPI-109 375

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 872: GCATGGCGGG CACAG 15

(2) INFORMATION FOR SEQ ID NO: 873: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 873: GCATGGCGGG CACA 14

(2) INFORMATION FOR SEQ ID NO: 874: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:874: GCATGGCGGG CAC 13

(2) INFORMATION FOR SEQ ID NO: 875: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:875: GCATGGCGGG CA 12

(2) INFORMATION FOR SEQ ID NO: 876: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:876: GCATGGCGGG C 11

(2) INFORMATION FOR SEQ ID NO: 877: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 877: GCATGGCGGG 10

(2) INFORMATION FOR SEQ ID NO: 878: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 878: CATGGCGGGC ACAGGCTGGG C 21

(2) INFORMATION FOR SEQ ID NO: 879: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:879: CATGGCGGGC ACAGGCTGGG 20

(2) INFORMATION FOR SEQ ID NO: 880: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid EPI-109 376

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 880: CATGGCGGGC ACAGGCTGG 19

(2) INFORMATION FOR SEQ ID NO:881: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:881: CATGGCGGGC ACAGGCTG 18

(2) INFORMATION FOR SEQ ID NO: 882: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 882: CATGGCGGGC ACAGGCT 17

(2) INFORMATION FOR SEQ ID NO: 883: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:883: CATGGCGGGC ACAGGC 16

(2) INFORMATION FOR SEQ ID NO: 884: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 884: CATGGCGGGC ACAGG 15

(2) INFORMATION FOR SEQ ID NO:885: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 885: CATGGCGGGC ACAG 14

(2) INFORMATION FOR SEQ ID NO: 886: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 886: CATGGCGGGC ACA 13

(2) INFORMATION FOR SEQ ID NO: 887: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 887: CATGGCGGGC AC 12

(2) INFORMATION FOR SEQ ID NO: 888: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 888: EPI-109 377

CATGGCGGGC A 11

(2) INFORMATION FOR SEQ ID NO: 889: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:889: CATGGCGGGC 10

(2) INFORMATION FOR SEQ ID NO:890: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 890: ATGGCGGGCA CAGGCTGGGC 20

(2) INFORMATION FOR SEQ ID NO: 891: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 891: ATGGCGGGCA CAGGCTGGG 19

(2) INFORMATION FOR SEQ ID NO: 892: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 892: ATGGCGGGCA CAGGCTGG 18

(2) INFORMATION FOR SEQ ID NO: 893: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 893: ATGGCGGGCA CAGGCTG 17

(2) INFORMATION FOR SEQ ID NO: 894: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 894: ATGGCGGGCA CAGGCT 16

(2) INFORMATION FOR SEQ ID NO: 895: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:895: ATGGCGGGCA CAGGC 15

(2) INFORMATION FOR SEQ ID NO: 896: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 896: ATGGCGGGCA CAGG 14

(2) INFORMATION FOR SEQ ID NO: 897: EPI-109 378

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 897: ATGGCGGGCA CAG 13

(2) INFORMATION FOR SEQ ID NO: 898: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 898: ATGGCGGGCA CA 12

(2) INFORMATION FOR SEQ ID NO:899: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 899: ATGGCGGGCA C 11

(2) INFORMATION FOR SEQ ID NO: 900: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 900: ATGGCGGGCA 10

(2) INFORMATION FOR SEQ ID NO: 901: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 901: TGGCGGGCAC AGGCTGGGC 19

(2) INFORMATION FOR SEQ ID NO: 902: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 902: TGGCGGGCAC AGGCTGGG 18

(2) INFORMATION FOR SEQ ID NO: 903: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 903: TGGCGGGCAC AGGCTGG 17

(2) INFORMATION FOR SEQ ID NO: 904: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 904: TGGCGGGCAC AGGCTG 16

(2) INFORMATION FOR SEQ ID NO: 905: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid EPI-109 379

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 905: TGGCGGGCAC AGGCT 15

(2) INFORMATION FOR SEQ ID NO: 906: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 906: TGGCGGGCAC AGGC 14

(2) INFORMATION FOR SEQ ID NO: 907: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 907: TGGCGGGCAC AGG 13

(2) INFORMATION FOR SEQ ID NO: 908: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 908: TGGCGGGCAC AG 12

(2) INFORMATION FOR SEQ ID NO: 909: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 909: TGGCGGGCAC A 11

(2) INFORMATION FOR SEQ ID NO: 910: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:910: TGGCGGGCAC 10

(2) INFORMATION FOR SEQ ID NO: 911: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 911: GGCGGGCACA GGCTGGGC 18

(2) INFORMATION FOR SEQ ID NO: 912: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 912: GGCGGGCACA GGCTGGG 17

(2) INFORMATION FOR SEQ ID NO: 913: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 913: EPI-109 380

GGCGGGCACA GGCTGG 16

(2) INFORMATION FOR SEQ ID NO: 914: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 914: GGCGGGCACA GGCTG 15

(2) INFORMATION FOR SEQ ID NO: 915: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 915: GGCGGGCACA GGCT 14

(2) INFORMATION FOR SEQ ID NO: 916: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 916: GGCGGGCACA GGC 13

(2) INFORMATION FOR SEQ ID NO: 917: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 917: GGCGGGCACA GG 12

(2) INFORMATION FOR SEQ ID NO: 918: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 918: GGCGGGCACA G 11

(2) INFORMATION FOR SEQ ID NO: 919: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 919: GGCGGGCACA 10

(2) INFORMATION FOR SEQ ID NO: 920: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 920: GCGGGCACAG GCTGGGC 17

(2) INFORMATION FOR SEQ ID NO: 921: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 921: GCGGGCACAG GCTGGG 16

(2) INFORMATION FOR SEQ ID NO: 922: EPI-109 381

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 922: GCGGGCACAG GCTGG 15

(2) INFORMATION FOR SEQ ID NO: 923: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 923: GCGGGCACAG GCTG 14

(2) INFORMATION FOR SEQ ID NO: 924: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 924: GCGGGCACAG GCT 13

(2) INFORMATION FOR SEQ ID NO: 925: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 925: GCGGGCACAG GC 12

(2) INFORMATION FOR SEQ ID NO: 926: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 926: GCGGGCACAG G 11

(2) INFORMATION FOR SEQ ID NO: 927: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 927: GCGGGCACAG 10

(2) INFORMATION FOR SEQ ID NO: 928:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 928: CGGGCACAGG CTGGGC 16

(2) INFORMATION FOR SEQ ID NO: 929: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 929: GGGCACAGGC TGGG 14

(2) INFORMATION FOR SEQ ID NO: 930: (l) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs EPI-109 382

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 930: CGGGCACAGG CTGG 14

(2) INFORMATION FOR SEQ ID NO: 931: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 931: CGGGCACAGG CTG 13

(2) INFORMATION FOR SEQ ID NO: 932: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 932: CGGGCACAGG CT 12

(2) INFORMATION FOR SEQ ID NO: 933: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 933: CGGGCACAGG C 11

(2) INFORMATION FOR SEQ ID NO: 934: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 934: CGGGCACAGG 10

(2) INFORMATION FOR SEQ ID NO: 935: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 935: GGGCACAGGC TGGGC 15

(2) INFORMATION FOR SEQ ID NO: 936: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 936: GGGCACAGGC TGGG 14

(2) INFORMATION FOR SEQ ID NO: 937: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 937: GGGCACAGGC TGG 13

(2) INFORMATION FOR SEQ ID NO: 938: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear EPI-109 383

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 938: GGGCACAGGC TG 12

(2) INFORMATION FOR SEQ ID NO: 939: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 939: GGGCACAGGC T 11

(2) INFORMATION FOR SEQ ID NO: 940: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 940: GGGCACAGGC 10

(2) INFORMATION FOR SEQ ID NO: 941: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:941: GGCACAGGCT GGGC 14

(2) INFORMATION FOR SEQ ID NO: 942: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 942: GGCACAGGCT GGG 13

(2) INFORMATION FOR SEQ ID NO: 943: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY- linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 943: GGCACAGGCT GG 12

(2) INFORMATION FOR SEQ ID NO: 944: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 944: GGCACAGGCT G 11

(2) INFORMATION FOR SEQ ID NO: 945: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 945: GGCACAGGCT 10

(2) INFORMATION FOR SEQ ID NO: 946: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 946: GCACAGGCTG GGC 1₃ EPI-109 384

(2) INFORMATION FOR SEQ ID NO: 947: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 947: GCACAGGCTG GG 12

(2) INFORMATION FOR SEQ ID NO: 948: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 948: GCACAGGCTG G 11

(2) INFORMATION FOR SEQ ID NO: 949: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 949: GCACAGGCTG 10

(2) INFORMATION FOR SEQ ID NO: 950: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 950: CACAGGCTGG GC 12

(2) INFORMATION FOR SEQ ID NO: 951: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 951: CACAGGCTGG G 11

(2) INFORMATION FOR SEQ ID NO: 952: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 952: CACAGGCTGG 10

(2) INFORMATION FOR SEQ ID NO: 953: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 953: ACAGGCTGGG C 11

(2) INFORMATION FOR SEQ ID NO: 954: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 954 : ACAGGCTGGG 10

(2) INFORMATION FOR SEQ ID NO: 955. (1) SEQUENCE CHARACTERISTICS. (A) LENGTH 10 base pairs EPI-109 385

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 955: CAGGCTGGGC 10

(2) INFORMATION FOR SEQ ID NO: 956: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 956: TTTTCCTTCC TTTGTCTCTC TTC 23

(2) INFORMATION FOR SEQ ID NO: 957: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 957: GCTCCCGGCT GCCTG 15

(2) INFORMATION FOR SEQ ID NO: 958: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 958: CTCGGCCGTG CGGCTCTGTC GCTCCCGGT 29

(2) INFORMATION FOR SEQ ID NO: 959: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 959: CCGCCGCCCT CCGGGGGGTC 20

(2) INFORMATION FOR SEQ ID NO: 960: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 960: TGCTGCCGTT GGCTGCCC 18

(2) INFORMATION FOR SEQ ID NO: 961: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 961: CTTCTGCGGG TCGCCGG 17

(2) INFORMATION FOR SEQ ID NO: 962: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 962: TGCTGGGCTT GTGGC 15

(2) INFORMATION FOR SEQ ID NO: 963: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear EPI-109 386

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 963: GGCCTCTCTT CTGGG 15

(2) INFORMATION FOR SEQ ID NO: 964: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 964: CCTGGTCCCT CCGT 14

(2) INFORMATION FOR SEQ ID NO: 965: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 965: GGTGGCTCCT CTGC 14

(2) INFORMATION FOR SEQ ID NO: 966: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 966: GCTTGGTCCT GGGGCTGC 18

(2) INFORMATION FOR SEQ ID NO: 967: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 967: TGCTCTCCTC TCCTT 15

(2) INFORMATION FOR SEQ ID NO: 968: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 968: TGCTTTTCTT TTCTGGGCCT C 21

(2) INFORMATION FOR SEQ ID NO: 969: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 969: TGTGGTCTGT TTTTTTCTG 19

(2) INFORMATION FOR SEQ ID NO: 970: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 970: GCCCTGCTGG GGCGCTCTCC 20

(2) INFORMATION FOR SEQ ID NO: 971: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:971: GCCGCCCGCC TGGCTCCC 18 EPI-109 387

(2) INFORMATION FOR SEQ ID NO: 972: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: Genomic DNA (xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 972: GGBGCCCBTG BTGGGCBTGC C 21

(2) INFORMATION FOR SEQ ID NO:973: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 973: GTGGTTCTTG CCCTCCTTTG GCTG 24

(2) INFORMATION FOR SEQ ID NO: 974: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 74: CCGTGCCCGC TCCCCGGC 18

(2) INFORMATION FOR SEQ ID NO: 975: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 975: CTCCTGGCGG GTGGCCGTTG 20

(2) INFORMATION FOR SEQ ID NO: 976: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 976: GGCCCGTGTT CCCCTGGG 18

(2) INFORMATION FOR SEQ ID NO: 977: (l) SEQUENCE CHARACTERISTICS-

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 977: GCCTGGGGCT CCCTTCTCTC 20

(2) INFORMATION FOR SEQ ID NO: 978: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 978: GCCCTTCTTG CTGGGCCTC 19

(2) INFORMATION FOR SEQ ID NO: 979: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 979: TGCTGCTGCT GGTGCTGTGG CCCCC 25

(2) INFORMATION FOR SEQ ID NO: 980: (1) SEQUENCE CHARACTERISTICS: EPI-109 388

(A) LENGTH: 43 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 980: GTACACCGAG GAGCCCATGA TGGGCATGCC ACAGACGACA GGC 43

(2) INFORMATION FOR SEQ ID NO: 981: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 43 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 981: GTBCBCCGBG GBGCCCBTGB TGGGCBTGCC BCBGBCGBCB GGC 43

(2) INFORMATION FOR SEQ ID NO: 982: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 982: GGCGCCGTGC CGCGTCTTGG TGGCGGCGG 29

(2) INFORMATION FOR SEQ ID NO: 983: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 983: GTTCGCGCCC GCGCGGGGCC CCTCCGGTCC 30

(2) INFORMATION FOR SEQ ID NO: 984: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 984 : GTTCGCGCCC GCGCGGGGCC CCTCCGGTCC 30

(2) INFORMATION FOR SEQ ID NO: 985: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 985: CGGGTCGGGG CCCCCCGCGG CC 22

(2) INFORMATION FOR SEQ ID NO: 986: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 986: GCCTCGGGGC TGGGGCGCTG GTGGCCGGG 29

(2) INFORMATION FOR SEQ ID NO: 987: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY- linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 987: CCGCGCCTCC GCCTGCCGCT TCTG 24

(2) INFORMATION FOR SEQ ID NO: 988: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid EPI-109 389

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 988: GCTGGGCCCC GGGCGCCCCC T 21

(2) INFORMATION FOR SEQ ID NO: 989: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 989: CCCCTCTTGC TCGGGTCCCC GTG 23

(2) INFORMATION FOR SEQ ID NO: 990: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 48 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 990: ACAGCGCGTC CTGTGTCTCC AGCAGCATGG CCGGGCCAGC TGGGCCCC 48

(2) INFORMATION FOR SEQ ID NO: 991: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 48 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: Single

(D) TOPOLOGY: linear

(li) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 991: BCBGCGCGTC CTGTGTCTCC BGCBGCBTGG CCGGGCCBGC TGGGCCCC 48

(2) INFORMATION FOR SEQ ID NO: 992: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 39 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 992: ACAGAGCATG CTGTTGTTGG GCATCTTGCC TTCCCAGGG 39

(2) INFORMATION FOR SEQ ID NO: 993: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 39 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(li) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIT'TION: SEQ ID NO: 993: BCBGBGCBTG CTGTTGTTGG GCBTCTTGCC TTCCCBGGG 39

(2) INFORMATION FOR SEQ ID NO:994: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 994: CCCTTTTCTG GTGGGGTG 18

(2) INFORMATION FOR SEQ ID NO: 995: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 995: GTGCTGTTGT TGGGC 15

(2) INFORMATION FOR SEQ ID NO: 996: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single EPI-109 390

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 996: TTTCTTCTGT TCCC 14

(2) INFORMATION FOR SEQ ID NO: 997: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 997: CCCTTTTCTG GTGGGGTG 18

(2) INFORMATION FOR SEQ ID NO: 998: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 998: GTGCTGTTGT TGGGC 15

(2) INFORMATION FOR SEQ ID NO: 999: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 999: TTTCTTCTGT TCCC 14

(2) INFORMATION FOR SEQ ID NO: 1000: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1000: TTTCCCCTGG GTCTTCC 17

(2) INFORMATION FOR SEQ ID NO: 1001: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1001: CTCCTGCTCT TTTTTC 16

(2) INFORMATION FOR SEQ ID NO: 1002: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 50 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1002: ATTTGCTCTC CTATTACTTT CTGTGTCCAT TTTTTCATTA ACCGAGCTGT 50

(2) INFORMATION FOR SEQ ID NO: 1003: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 50 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1003: BTTTGCTCTC CTBTTBCTTT CTGTGTCCBT TTTTTCBTTB BCCGBGCTGT 50

(2) INFORMATION FOR SEQ ID NO: 1004: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1004: EPI-109 391

GCCTGTGTCT GTCCTCCT 18

(2) INFORMATION FOR SEQ ID NO: 1005: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1005: GCTTCGTTCC TCTCGTTC 18

(2) INFORMATION FOR SEQ ID NO: 1006: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1006: CTGCTTGGTG CCCTTGCCG 19

(2) INFORMATION FOR SEQ ID NO: 1007: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1007: GTCCTGCTCC TCCGGGCTGT GG 22

(2) INFORMATION FOR SEQ ID NO: 1008: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 36 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1008: GTCGTGGCCC TGGCTCCGGC TGGTGGGCTC CCCTGG 36

(2) INFORMATION FOR SEQ ID NO: 1009: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1009: CCTTCGCTGG CTGGCGGCGT GC 22

(2) INFORMATION FOR SEQ ID NO: 1010: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1010: GGGTCTTGCT CTGGGCCTGG CTGT 24

(2) INFORMATION FOR SEQ ID NO: 1011: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID Nθ:1011: GGCCGTGGTT GGGGGTCTTC 20

(2) INFORMATION FOR SEQ ID NO: 1012: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1012: GCTGCCTCCG TTTGGGTGGC 20

(2) INFORMATION FOR SEQ ID NO:1013: EPI-109 392

(1) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 50 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1013: TCTCTGAATA TTGACCTTCC TCCATGGCGG TCCTGCTTGG ATTCTCCCGA 50

(2) INFORMATION FOR SEQ ID NO: 1014: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 50 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1014: TCTCTGBBTB TTGBCCTTCC TCCBTGGCGG TCCTGCTTGG BTTCTCCCGB 50

(2) INFORMATION FOR SEQ ID NO: 1015: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 39 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1015: GCCTTTCCTG GTTCTCTTGT TGTTTTTGGG GTTTGGCTT 39

(2) INFORMATION FOR SEQ ID NO: 1016: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 50 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1016: ACAGTAGAGT AGGGGATTCC ATGGCAGGAG CCATCTTCTT CATGGACTCC 50

(2) INFORMATION FOR SEQ ID NO: 1017: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 50 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1017: TTCAAGGAGA CCTTAGGTTT CTGAGGGACT GCTAACACGC CATCTGGAGC 50

(2) INFORMATION FOR SEQ ID NO: 1018: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 77 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(li) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1018: BCBGTBGBGT BGGGGBTTCC BTGGCBGGBG CCBTCTTCTT CBTGGBCTCC TTCBBGGBGB 60 CCTTBGGTTT CTGBGGG 77

(2) INFORMATION FOR SEQ ID NO: 1019: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1019: BCTGCTBBCB CGCCBTCTGG BGC 23

(2) INFORMATION FOR SEQ ID NO: 1020: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1020: GTTGTTTTTG GGGTTTGGCT T 21 EPI-109 393

(2) INFORMATION FOR SEQ ID NO: 1021: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1021: GCCTTTCCTG GTTCTCTT 18

(2) INFORMATION FOR SEQ ID NO: 1022: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 50 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1022: BCBGTBGBGT BGGGGBTTCC BTGGCBGGBG CCBTCTTCTT CBTGGBCTCC 50

(2) INFORMATION FOR SEQ ID NO: 1023: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 50 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1023: TTCBBGGBGB CCTTBGGTTT CTGBGGGBCT GCTBBCBCGC CBTCTGGBGC 50

(2) INFORMATION FOR SEQ ID NO: 1024: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1024: GCCTGTGTCT GTCCTCCT 18

(2) INFORMATION FOR SEQ ID NO:1025: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1025: GCTTCGTTCC TCTCGTTC 18

(2) INFORMATION FOR SEQ ID NO: 1026: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1026: CTGCTTGGTG CCCTTGCCG 19

(2) INFORMATION FOR SEQ ID NO: 1027: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1027: GTCCTGCTCC TCCGGGCTGT GG 22

(2) INFORMATION FOR SEQ ID NO: 1028: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 36 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1028: GTCCTCGCCC TGGCTCCGGC TGGTGGGCTC CCCTGG 36

(2) INFORMATION FOR SEQ ID NO: 1029: EPI-109 394

( 1 ) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1029. CCTTCGCTGG CTGGCGGCGT GC 22

(2) INFORMATION FOR SEQ ID NO:1030: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1030: CCCBGBBCGB GBCCCGGBCC GBCB 24

(2) INFORMATION FOR SEQ ID NO: 1031: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1031: GGCCGTGGTT GGGGGTCTTC 20

(2) INFORMATION FOR SEQ ID NO: 1032: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1032: GCTGCCTCCG TTTGGGTGGC 20

(2) INFORMATION FOR SEQ ID NO: 1033: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 40 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(li) MOLECULE TYPE: Genomic DNA ( i) SEQUENCE DESCRIPTION: SEQ ID NO: 1033: GBTCTCTGBB TBTTGBCCTT CCBTGGCGGT CCTGCTTGGB 40

(2) INFORMATION FOR SEQ ID NO: 1034: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1034: TCTCCCTTGG GCTCTGGCTC CTTCTC 26

(2) INFORMATION FOR SEQ ID NO: 1035: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1035: TCTCTCTCCC TCTCTCTCTG T 21

(2) INFORMATION FOR SEQ ID NO: 1036: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1036: CGCCTCCGCC CTGGCTGCTG GGGTGGTGGT GC 32

(2) INFORMATION FOR SEQ ID NO: 1037: (l) SEQUENCE CHARACTERISTICS: EPI-109 395

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1037: TTTTGTTCTT CCTTGCTGCC 20

(2) INFORMATION FOR SEQ ID NO: 1038: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1038: GCCCCGCTGC TTGTCTTCCT CG 22

(2) INFORMATION FOR SEQ ID NO: 1039: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 50 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1039: CTCTGTCCCT CTCTCTCTGT BCTCCTCBGG CTCCBTCBTC TCCCTTGGGC 50

(2) INFORMATION FOR SEQ ID NO: 1040: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1040: CTTGCTCCTG GGGGCCTCCT G 21

(2) INFORMATION FOR SEQ ID NO:1041: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1041: GTCCCTCCGG GTGTTCCCGG C 21

(2) INFORMATION FOR SEQ ID NO: 1042: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 81 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1042: GGGCCTGGCC TGGGGCBGGG GCCGCGTBGG CGCGGCTCGC CBGGBCGGGC BGCGCCBGCB 60 GCBGCBGBTT CBGCBTCCTG G 81

(2) INFORMATION FOR SEQ ID NO: 1043: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1043: CTTGCTCCTG GGGGCCTCCT G 21

(2) INFORMATION FOR SEQ ID NO: 1044: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1044: GTCCCTCTGG CTGTTCCCGG C 21

(2) INFORMATION FOR SEQ ID NO: 1045: (l) SEQUENCE CHARACTERISTICS: EPI-109 396

(A) LENGTH: 90 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1045:

CCTGGBCTGG GGCBGGGGCC GCGTBGGCGC GGCTCGCCBG GBCGGGCBGC GCCBGCBGCB 60

GCBGGCTCBG CBTCCTGGCC BCGGBBTTCC 90

(2) INFORMATION FOR SEQ ID NO: 1046: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1046: GGTGTGCGGG GCCTGGTGCC 20

(2) INFORMATION FOR SEQ ID NO: 1047: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(XI) SEQUENCE DESCRIPTION: SEQ ID NO: 1047: CCTGGGCCTC GGGTGCTGCC TGT 23

(2) INFORMATION FOR SEQ ID NO:1048: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1048: GCGCTGCCTT CTTCTCCTGG 20

(2) INFORMATION FOR SEQ ID NO: 1049: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1049: GTCCTCGCCG GGGCCCTTGC TGCCCTGGCT GT ₃2

(2) INFORMATION FOR SEQ ID NO: 1050: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1050: GCCCTGGGGG TCTGGGTTCG GCTGT 25

(2) INFORMATION FOR SEQ ID NO: 1051: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 60 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1051: CCCCBGCBGG BCCBGTCCCB TCCBCBGCGT GTGBTGBGTB GCCBTTCTCC TGCBGCCGBG 60

(2) INFORMATION FOR SEQ ID NO: 1052: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1052: GGGCGCGGGC GBGCBTCGC 19

(2) INFORMATION FOR SEQ ID NO: 1053: EPI-109 397

(1) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1053: TTTGGGCTTT TCTCCTTTGG TT 22

(2) INFORMATION FOR SEQ ID NO: 1054: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 60 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1054: TGBGCGCCBG GBCCGCGCBC BGCBGCBGGG CGCGGGCGBG CBTCGCBGCG GCGGGCBGGG 60

(2) INFORMATION FOR SEQ ID NO: 1055: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1055: GCCCTGCTGC TCTTTCTGCT 20

(2) INFORMATION FOR SEQ ID NO: 1056: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1056: TCCCTTGGTG GGTTGGGCC 19

(2) INFORMATION FOR SEQ ID NO: 1057: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1057: TTGCTGCCCC TTCTGTCCC 19

(2) INFORMATION FOR SEQ ID NO: 1058: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1058: TTGCTGCCCC TTCTGTCCC 19

(2) INFORMATION FOR SEQ ID NO: 1059: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1059: TGTTTGCTGG TGTCTGCGC 19

(2) INFORMATION FOR SEQ ID NO: 1060: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 60 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1060: CCCCBBCBGB BGBBGCBGBC BBBTTTGGGB BGTGBBCBGT TTTGGBBCCB TGTTTCCTGT 60

(2) INFORMATION FOR SEQ ID NO: 1061: (l) SEQUENCE CHARACTERISTICS: EPI-109 398

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1061: GCGCTCGGCC TGGTCCCGG 19

(2) INFORMATION FOR SEQ ID NO: 1062: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1062: GGGTCTCCTC TTGTTGTTGC 20

(2) INFORMATION FOR SEQ ID NO:1063: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1063: TTGCGCCTCC TGCTGGGGGT CC 22

(2) INFORMATION FOR SEQ ID NO: 1064: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1064: CTCTGTTCTT GTTTTGGGGG C 21

(2) INFORMATION FOR SEQ ID NO: 1065: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1065: GGGCCCGGCC GTTGTCTTG 19

(2) INFORMATION FOR SEQ ID NO: 1066: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1066: GTTTGGGGGT TTCCGTTG 18

(2) INFORMATION FOR SEQ ID NO: 1067: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1067: GGGTTCTCCT GGCCCGGGCC TTGCCC 26

(2) INFORMATION FOR SEQ ID NO: 1068: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1068: GGCCGTGGTC CCGGCTTCGT TGC 23

(2) INFORMATION FOR SEQ ID NO: 1069: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single EPI-109 399

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1069: CCTGTCTCCG TCTCGGCTCT TCTG 24

(2) INFORMATION FOR SEQ ID NO: 1070: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1070: GGGCCTTGCG CTGTCTTTGG TG 22

(2) INFORMATION FOR SEQ ID NO: 1071: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 60 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1071: GCBCCGTCCB GTGBTGGTGC GGTBCTTGTC GCTGCBGCGC TCGGCCTGGT CCCGGBGBGC 60

(2) INFORMATION FOR SEQ ID NO: 1072: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1072: GCGCGGGCCG GGGGCTGCTG GG 22

(2) INFORMATION FOR SEQ ID NO:1073: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1073: GGTTGGCCCG GGGTGCCCC 19

(2) INFORMATION FOR SEQ ID NO: 1074: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1074: GCCGCTGGGT GCCCTCGTCC TCTGCGGTC 29

(2) INFORMATION FOR SEQ ID NO: 1075: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1075: GTGTCTCCTG GCTCTGGTTC CCC 23

(2) INFORMATION FOR SEQ ID NO: 1076: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1076: GCTGCGCCCG TTGTCCTCTG GGGTGGCCTT C 31

(2) INFORMATION FOR SEQ ID NO: 1077: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1077: EPI-109 400

GCTCCCGGGT CTGGTTCTTG TGT 23

(2) INFORMATION FOR SEQ ID NO: 1078: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1078: TGGGGGTCCC TTTTTGGGCC TGTTGT 26

(2) INFORMATION FOR SEQ ID NO:1079: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1079: GGCGTGGCTT GTGTGTTCGG TTTC 24

(2) INFORMATION FOR SEQ ID NO: 1080: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1080: TGCCCTGTCC TCCGGCGTCC C 21

(2) INFORMATION FOR SEQ ID NO: 1081: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 142 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1081:

CGGBGCCTCC CCGGGGCBGG BTGBCTTTTG BGGGGGBCBC BGBTGTCTGG GCBTTGCCBG 60

GTCCTGGGBB CBGBGCCCCG BGCBGGBCCB GGBGTGCGGG CBGCGCGGGC CGGGGGCTGC 120

TGGGBGCCBT BGCGBGGCTG BG 142

(2) INFORMATION FOR SEQ ID NO: 1082: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1082: CCTCTTTTCT GTTTTTCCC 19

(2) INFORMATION FOR SEQ ID NO: 1083: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1083: CTCTGCCTTT GTTTGGGTTC G 21

(2) INFORMATION FOR SEQ ID NO: 1084: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1084: CTTCCTTTCT GCTTCTTCC 19

(2) INFORMATION FOR SEQ ID NO: 1085: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1085: EPI-109 401

CTGTGTCTCC TGTCTCCGCT TTTTTCTTC 29

(2) INFORMATION FOR SEQ ID NO: 1086: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1086: GTCTTTGTTG TTTTCTCTTC CTTG 24

(2) INFORMATION FOR SEQ ID NO: 1087: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 130 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1087: CTGBGCBBGB TBTCTBGBTT CTGGGGTGGT CTCGBTTTTB BBBGCTTGBG BBGCTGCBBB 60 CBTTBTCCBB BGTBTBTTTG BGGCTCCBBG GBTCBCGBCC BTCTTCCCBG GCBTTTTBBG 120 TTGCTGTCGT 1₃0

(2) INFORMATION FOR SEQ ID NO: 1088: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1088: GTTCTTGGCT TCTTCTGTC 19

(2) INFORMATION FOR SEQ ID NO: 1089: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1089: CGTTGGCTTC TCGTTGTCCC 20

(2) INFORMATION FOR SEQ ID NO: 1090: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1090: TGTGGGCTTC TCGTTGTCCC 20

(2) INFORMATION FOR SEQ ID NO: 1091: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1091: CCCTTCGGGG GCTGGTGG 18

(2) INFORMATION FOR SEQ ID NO: 1092: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1092: GGCTGGTGG 9

(2) INFORMATION FOR SEQ ID NO: 1093: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1093: EPI-109 402

GGCCGTCCTT GCCTGCTGG 19

(2) INFORMATION FOR SEQ ID NO: 1094: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 41 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1094: TTTTCTCTTT CGCTTTCTTT TCGTCTCCTG TTCCTCCTTT T 41

(2) INFORMATION FOR SEQ ID NO: 1095: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 36 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1095: TTGCTGTTTT TTCTCCTTCT TCTCTCCTTT CTTTTC 36

(2) INFORMATION FOR SEQ ID NO: 1096: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 41 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1096: TTTTCTCTTT CGCTTTCTTT TCGTCTCCTG TTCCTCCTTT T 41

(2) INFORMATION FOR SEQ ID NO: 1097: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 36 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1097: TTGCTGTTTT TTCTCCTTCT TCTCTCCTTT CTTTTC 36

(2) INFORMATION FOR SEQ ID NO: 1098: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1098: CTCTGTCTTG TTCTGGTCCT TCGTGGGGCT CTG 33

(2) INFORMATION FOR SEQ ID NO: 1099: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1099: TGTCGCGTGG GTGCGGCCGT GGCC 24

(2) INFORMATION FOR SEQ ID NO: 1100: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 69 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1100: GGCGGBCCBG GBGTTGGBGC BGGBGCBGGB CGGGCBGGCG GCTCBTGTTT GGBTCGGCBG 60 GBGGCBCTC 69

(2) INFORMATION FOR SEQ ID NO: 1101: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1101: TCTGGGGTGT CCTG 14 EPI-109 403

(2) INFORMATION FOR SEQ ID NO: 1102:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1102: GCCTTCGTGG TTCC 14

(2) INFORMATION FOR SEQ ID NO: 1103: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1103: TCTTCCTTCG TTTGC 15

(2) INFORMATION FOR SEQ ID NO: 1104: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1104: GGCTGCGCTC CTGCCCCGC 19

(2) INFORMATION FOR SEQ ID NO: 1105: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1105: GGCTGCGCTC CTGCCCCGC 19

(2) INFORMATION FOR SEQ ID NO: 1106: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1106: CTCTTTCCCG GGCTCTT 17

(2) INFORMATION FOR SEQ ID NO:1107: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1107: GCGCTGGGGG GTGCTCC 17

(2) INFORMATION FOR SEQ ID NO: 1108: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1108: CGTGTGTTTG CGCCCTCCTC CTGGTCGC 28

(2) INFORMATION FOR SEQ ID NO:1109: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1109: GCTTGTCGTT TTGG 14

(2) INFORMATION FOR SEQ ID NO: 1110: EPI-109 404

(l) SEQUENCE CHARACTERISTICS.

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1110: GGCCGGCTTT GCCCGCCTCC C 21

(2) INFORMATION FOR SEQ ID NO:llll: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1111: GGCGCCTGGC CCGGCC 16

(2) INFORMATION FOR SEQ ID NO: 1112: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1112: TTCCTGGGCT GCGTGCGC 18

(2) INFORMATION FOR SEQ ID NO: 1113: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1113: GTTCTGTTCT TCTTCCTGGC 20

(2) INFORMATION FOR SEQ ID NO: 1114: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 78 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1114: GCBGGBGBCB GGGCBGGGCG BTCBGGBGCB GCGTGBGCCB BBGGBGGBCC BTCGGGBBCG 60 CBGCTCCGGB BCGCBGGB 78

(2) INFORMATION FOR SEQ ID NO: 1115: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1115: CTCTGGTTGG CTTCCTTC 18

(2) INFORMATION FOR SEQ ID NO: 1116: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 70 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1116:

GCCGGCBCBT GCTBGCBGGB BGBBCBGBGG GGGBBGCBGT TGGGBGGTGB GBCCCBTTBB 60

TBGGTGTCGB 70

(2) INFORMATION FOR SEQ ID NO: 1117: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1117: TCTGCGCGCC CCTGCTCC 18 EPI-109 405

(2) INFORMATION FOR SEQ ID NO: 1118: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1118: CGCCCGGCTT CTCT 14

(2) INFORMATION FOR SEQ ID NO: 1119: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1119: CGTGTGGGCT TCGG 14

(2) INFORMATION FOR SEQ ID NO: 1120: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1120: CCCCGCGCCT CCGTTGTTCT C 21

(2) INFORMATION FOR SEQ ID NO: 1121: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1121: TGCTCGCTGG GCTTG 15

(2) INFORMATION FOR SEQ ID NO: 1122: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1122: GGTTTCCTGG GGCCCTGGGT TTC 23

(2) INFORMATION FOR SEQ ID NO: 1123: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1123: TCTGCCGGGT CGTTTTC 17

(2) INFORMATION FOR SEQ ID NO: 1124: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1124: GGGTGCTGGC TGCG 14

(2) INFORMATION FOR SEQ ID NO: 1125: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1125: CTTGGTGCTG GGGCTCC 17

(2) INFORMATION FOR SEQ ID NO: 1126: (l) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs EPI-109 406

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1126: GGCGGCTGCG GGCTGGGTTG GG 22

(2) INFORMATION FOR SEQ ID NO: 1127: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1127: CTTGGCTGGT TCCTGGCCTC GGG 23

(2) INFORMATION FOR SEQ ID NO: 1128: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 35 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1128: CCTCCTCCTC CTCCTCGCTC CCTTTTTCTT CCTCT 35

(2) INFORMATION FOR SEQ ID NO: 1129: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1129: TCCCTGCTGC TCTC 14

(2) INFORMATION FOR SEQ ID NO: 1130: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1130: TGCCCTCCCT TCCCTCCTGG 20

(2) INFORMATION FOR SEQ ID NO:1131: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1131: GGTGCCTCCT TGGGCCCTGC 20

(2) INFORMATION FOR SEQ ID NO: 1132: (l) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1132: GGCTGCTCCT TGCCCC 16

(2) INFORMATION FOR SEQ ID NO: 1133: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1133: CTCTGGGTCG GGCTGGC 17

(2) INFORMATION FOR SEQ ID NO: 1134: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear EPI-109 407

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1134: GGGGCGTCTC TGTGC 15

(2) INFORMATION FOR SEQ ID NO: 1135: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1135: CTGGCCTGGG TGCC 14

(2) INFORMATION FOR SEQ ID NO: 1136: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 1136: GCCTCTCCTG GGGGGGTGGC TCCCTGTCC 29

(2) INFORMATION FOR SEQ ID NO: 1137: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1137: CCTTTTCCCC CGGCTCC 17

(2) INFORMATION FOR SEQ ID NO: 1138: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1138: GTGGGGGCTT TGGC 14

(2) INFORMATION FOR SEQ ID NO: 1139: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1139: GGGGGTCTGT GGCCTGCTCC TGGGG 25

(2) INFORMATION FOR SEQ ID NO: 1140: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1140: AGGGGTCTGG GGCCCTC 17

(2) INFORMATION FOR SEQ ID NO: 1141: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1141: TTTTGGGGGT CTGGCTTG 18

(2) INFORMATION FOR SEQ ID NO: 1142: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 1142 : GCCTGGCTGC CTTCC 15 EPI-109 408

(2) INFORMATION FOR SEQ ID NO: 1143: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1143: GGGGCCTGCC GTGGGGC 17

(2) INFORMATION FOR SEQ ID NO: 1144: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1144: TGTCCTCTGT TGCTCCCCTT 20

(2) INFORMATION FOR SEQ ID NO: 1145: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1145: TGCCTGCTGT CTGG 14

(2) INFORMATION FOR SEQ ID NO:1146: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 1146: GGTTCCCGCC TTCCCT 16

(2) INFORMATION FOR SEQ ID NO:1147: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 100 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1147: GTTCCCAGAG CTTGCCACCT GCAGCAGGAC CAGGCAGCTC ACAGGGAACA GGAGCCCAGA 60 GCAAAGCCAC CCCATTGGGA GATGCCAAGG CACCAGGCTG 100

(2) INFORMATION FOR SEQ ID NO:1148: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 100 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1148: GTTCCCBGBG CTTGCCBCCT GCBGCBGGBC CBGGCBGCTC BCBGGGBBCB GGBGCCCBGB 60 GCBBBGCCBC CCCBTTGGGB GBTGCCBBGG CBCCBGGCTG 100

(2) INFORMATION FOR SEQ ID NO:1149: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1149: TCCCTGTTTC CCCCCTTT 18

(2) INFORMATION FOR SEQ ID NO: 1150: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1150: CGTTCTGCGT TTGCCTTTGG C 21 EPI-109 409

(2) INFORMATION FOR SEQ ID NO: 1151: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1151: GTTTTTTGTT TGTTTTCT 18

(2) INFORMATION FOR SEQ ID NO: 1152: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1152: CTCTCCGTCT TTCTTCTCC 19

(2) INFORMATION FOR SEQ ID NO: 1153: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 1153: CCTCCTGCCT GTGTCCCTGC TCCCC 25

(2) INFORMATION FOR SEQ ID NO: 1154: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1154: GAGGGTTTCT GGCTTCCTCT CT 22

(2) INFORMATION FOR SEQ ID NO: 1155: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1155: TGTCTCTCTG TCCTTTTGTT 20

(2) INFORMATION FOR SEQ ID NO: 1156: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1156: TGTTGTGCGG CCTGGTGCTG CCCTGCCCCG GG 32

(2) INFORMATION FOR SEQ ID NO:1157: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 89 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1157: GTGGGBBTTT CTGTGGGGBT GGCBTBCBCG TBGGCBGCTC CBBGBGCTBG CBBBCTCBBB 60 TGCBGBBGCB TCCTCBTGGC TCTGBBBCG 89

(2) INFORMATION FOR SEQ ID NO: 1158: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1158: GTGTGTCTTT GCTGT 15

(2) INFORMATION FOR SEQ ID NO: 1159: EPI-109 410

(l) SEQUENCE CHARACTERISTICS.

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1159: TTCCTTTGCT CTTG 1

(2) INFORMATION FOR SEQ ID NO:1160: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1160: GTGTGTCTTT GCTGT 15

(2) INFORMATION FOR SEQ ID NO: 1161: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1161: GCCCTGCCTC TCTGC 15

(2) INFORMATION FOR SEQ ID NO: 1162: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1162: GGGGGTGGCT TCCTGCC 17

(2) INFORMATION FOR SEQ ID NO: 1163: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1163: GCGTCTCTGG GCCGTCCC 18

(2) INFORMATION FOR SEQ ID NO: 1164: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 36 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1164: GTCCCTCGGC CCCGCGCCGC GCTCGGCTCC TCTCCC 36

(2) INFORMATION FOR SEQ ID NO: 1165: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1165: TCTGGCCCGG CTC 1₃

(2) INFORMATION FOR SEQ ID NO:1166: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1166: GGGGCGGGGC GGGGCGGTGG GCGGGC 26

(2) INFORMATION FOR SEQ ID NO: 1167: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid EPI-109 411

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1167: GGCGCTGCCC TGCGC 15

(2) INFORMATION FOR SEQ ID NO: 1168: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1168: TGCTGGCCGT CGGCTGCGCG CTGCTGGCTG CCCT 34

(2) INFORMATION FOR SEQ ID NO: 1169: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1169: TGCTGGCCGT CGGCTGCGCG CTGCTGGCTG CCCT 34

(2) INFORMATION FOR SEQ ID NO: 1170: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1170: GCTGGCCGCG CCGGG 15

(2) INFORMATION FOR SEQ ID NO: 1171: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1171: GCCTGTCCGC CTCTGCGGG 19

(2) INFORMATION FOR SEQ ID NO:1172: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1172: CGCTGTCTCC TGGC 14

(2) INFORMATION FOR SEQ ID NO: 1173: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1173: TTGTCTTCCG GCTCT 15

(2) INFORMATION FOR SEQ ID NO: 1174: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1174: TCTGCTGGGG TGGG 14

(2) INFORMATION FOR SEQ ID NO: 1175: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1175: EPI-109 41

GCTGGGCGGC CGGCCCGGT 19

(2) INFORMATION FOR SEQ ID NO: 1176: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1176: GCTGGGGCTC CTCGGGGGG 19

(2) INFORMATION FOR SEQ ID NO: 1177: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1177: GGGGGCTCTT CCGG 14

(2) INFORMATION FOR SEQ ID NO: 1178: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1178: GCTGTCTCCC TCCGGG 16

(2) INFORMATION FOR SEQ ID NO: 1179: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1179: GCGGGGGTTT CTGGCC 16

(2) INFORMATION FOR SEQ ID NO: 1180: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1180: GTGGGGGTCT TGCC 14

(2) INFORMATION FOR SEQ ID NO: 1181: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1181: TGGCCTCCGG GCTCC 15

(2) INFORMATION FOR SEQ ID NO: 1182: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1182: TGCTTGTCTT GCCTTCCTTC 20

(2) INFORMATION FOR SEQ ID NO:1183: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1183: TCTGGTCGGT TGTGGCTCG 19

(2) INFORMATION FOR SEQ ID NO: 1184: EPI-109 413

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1184: GGGCTCCGTG GGTCCCTGGC 20

(2) INFORMATION FOR SEQ ID NO: 1185: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1185: GCCCGTTTGT GTTTTGTC 18

(2) INFORMATION FOR SEQ ID NO: 1186: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1186: TTTTCCCCTG GCGT 14

(2) INFORMATION FOR SEQ ID NO: 1187: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 35 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1187: CCCTGTGCCC CTCTCCTCTC CTTCCTCTGC TTCTC 35

(2) INFORMATION FOR SEQ ID NO:1188: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1188: GCTCTCCTTT GTGGG 15

(2) INFORMATION FOR SEQ ID NO: 1189: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 1189: GCCCTCCCTG CTGCT 15

(2) INFORMATION FOR SEQ ID NO: 1190: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1190: CTTGGTTTTG GGCT 14

(2) INFORMATION FOR SEQ ID NO: 1191: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1191: TTTTTTCTCT TCCTCCTTTT TC 22

(2) INFORMATION FOR SEQ ID NO: 1192: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid EPI-109 414

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1192: GTGCGTGGGC CTCC 1₄

(2) INFORMATION FOR SEQ ID NO: 1193: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1193: CCCGGCGC 8

(2) INFORMATION FOR SEQ ID NO: 1194: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 150 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1194:

GCACGCCTCT TGCCACCTCC TGCGCAGGGC AGCGCCTTGG GGCCAGCGCC GCTCCCGGCG 60

CGGCCAGCAG GGCAGCCAGC AGCGCGCAGC CGACGGCCAG CATGCTTCCT CCTCGGCTAC 120

CACTCCATGG TCCCGCAGAG GCGGACAGGC 150

(2) INFORMATION FOR SEQ ID NO: 1195: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1195: GGCCBGCBGG 10

(2) INFORMATION FOR SEQ ID NO: 1196: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 150 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1196: GCBCGCCTCT TGCCBCCTCC TGCGCBGGGC BGCGCCTTGG GGCCBGCGCC GCTCCCGGCG 60 CGGCCBGCBG GGCBGCCBGC BGCGCGCBGC CGBCGGCCBG CBTGCTTCCT CCTCGGCTBC 120 CBCTCCBTGG TCCCGCBGBG GCGGBCBGGC 150

(2) INFORMATION FOR SEQ ID NO: 1197: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1197: GCTTCTCTTT CGTTCCCGGT GGGCTCG 27

(2) INFORMATION FOR SEQ ID NO:1198:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1198: GTGGCTGTCT GTGTGGGGCG GCT 23

(2) INFORMATION FOR SEQ ID NO: 1199: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1199: GTGCCTCTTT GCTGCTTTC 19 EPI-109 415

(2) INFORMATION FOR SEQ ID NO: 1200: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1200: GATTCTTTGC CTTTTTCTGC 20

(2) INFORMATION FOR SEQ ID NO: 1201: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID Nθ:1201: GCTTGTGTGC TCTGCTGTCT CT 22

(2) INFORMATION FOR SEQ ID NO: 1202: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 37 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1202: TGGTTCCTTC CGGTGGTTTC TTCCTGGCTC TTGTCCT 37

(2) INFORMATION FOR SEQ ID NO: 1203: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1203: TTCTCTTGGC CCTTGGC 17

(2) INFORMATION FOR SEQ ID NO: 1204: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 39 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1204: TGGTGGGGCT GGGGCTCCGG GGTCTCTGCC CCTCCGTGC 39

(2) INFORMATION FOR SEQ ID NO: 1205: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1205: CGCGTGGGGC CGCGCTCGCC GGCCCCCC 28

(2) INFORMATION FOR SEQ ID NO: 1206: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1206: CCTGCCGGGT GGGCTCCCGC CGCG 24

(2) INFORMATION FOR SEQ ID NO: 1207: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1207: CGCCGGCCTG CCGGCCCCTC 20

(2) INFORMATION FOR SEQ ID NO: 1208: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 39 base pairs O 00/09525

EPI-109 416

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1208: GTGGGTCCTG CTGGCCGGGT CCGGGTCCCG GGGGTGGGG 39

(2) INFORMATION FOR SEQ ID NO:1209: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1209: CGCGBGTCGG CGGCCGBGGG TC 22

(2) INFORMATION FOR SEQ ID NO: 1210: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1210: GGCCTCCBCC BGGGBCBTG 19

(2) INFORMATION FOR SEQ ID NO: 1211: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1211: GTCCTTCTTG TCCGCTGCC 19

(2) INFORMATION FOR SEQ ID NO: 1212: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1212: TCTCTGGGGT TTTCGGTCTG GGTGG 25

(2) INFORMATION FOR SEQ ID NO: 1213: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1213: GCTTTCCTCC TGGGGCTGCT GCTG 24

(2) INFORMATION FOR SEQ ID NO: 1214: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1214: GGCTCTTCTT TTTGTTTCTG GCCTGGTG 28

(2) INFORMATION FOR SEQ ID NO:1215: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1215: CTCTCTCGTG CCCTTTCC 18

(2) INFORMATION FOR SEQ ID NO: 1216: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid EPI-109 417

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1216: CTTGGGTGTC TTGTTTTTGT 20

(2) INFORMATION FOR SEQ ID NO: 1217: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1217: GGCCTCCBCC BGGGBCBTG 19

(2) INFORMATION FOR SEQ ID NO: 1218: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1218: GTGGGGCCTG CTCTCCCGGC CTCCG 25

(2) INFORMATION FOR SEQ ID NO: 1219: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1219: TGTGTTGCTG GGTGTTTTCC CGTCTCTGG 29

(2) INFORMATION FOR SEQ ID NO: 1220: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1220: TCTGCCTTCG GGGGTCGT 18

(2) INFORMATION FOR SEQ ID NO: 1221: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1221: GGGTCCTCBT GGCTGGGG 18

(2) INFORMATION FOR SEQ ID NO: 1222: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1222: GCCTGGGCCT GCBGGGCC 18

(2) INFORMATION FOR SEQ ID NO: 1223: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1223: GCTCTTGCCT GGBGTGGCTC 20

(2) INFORMATION FOR SEQ ID NO: 1224: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs EPI-109 418

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1224: GCCCBGBGTC TTCCCTGGT 19

(2) INFORMATION FOR SEQ ID NO: 1225: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear •

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1225: GGGTCCTCBT GGCTGGGGTC 20

(2) INFORMATION FOR SEQ ID NO: 1226: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1226: CCTCTCTCCC GTCCT 15

(2) INFORMATION FOR SEQ ID NO: 1227: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1227: GTCTTTGTTT CTGGGCTCGT GCC 23

(2) INFORMATION FOR SEQ ID NO: 1228: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear .

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1228: CCBTCCCGGC TTCTCTCTGG TTCC 24

(2) INFORMATION FOR SEQ ID NO:1229: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1229: GTCCTCTGTG GTGTTTGG 18

(2) INFORMATION FOR SEQ ID NO: 1230: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1230: CCCTGCTTCC TTTTGCCTGT T 21

(2) INFORMATION FOR SEQ ID NO: 1231: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 85 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1231: GAGGGGGCAG CAGTTGGGCC CCAAAGGCCC TCTCGTTCAC CTTCTGGCAC GGAGTTGCAT 60 CCCCATAGTC AAACTCTGTG GTCGT 85

(2) INFORMATION FOR SEQ ID NO: 1232: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 59 base pairs EPI-109 419

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1232: GTCATAGTCC TCTGTGGTGT TTGGAGTTTC CATCCCGGCT TCTCTCTGGT TCCAAGGGA 59

(2) INFORMATION FOR SEQ ID NO: 1233: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 86 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1233: GBGGGGGCBG CBGTTGGGCC CCBBBGGCCC TCTCGTTCBC CTTCTGGCBC GGBGTTGCBT 60 CCCCBTBGTC BBBCTCTGTG GTCGTG 86

(2) INFORMATION FOR SEQ ID NO: 1234: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 58 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1234: TCBTBGTCCT CTGTGGTGTT TGGBGTTTCC BTCCCGGCTT CTCTCTGGTT CCBBGGGB 58

(2) INFORMATION FOR SEQ ID NO: 1235: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 84 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1235: GGGCBCGGGG CBGTGGGCGG GCBBTGTBGG CBBBGCBGCB GGGTGTGGTG TCCGBGGBBT 60 BTGGGGBGGC BGBTGCBGGB GCGC 84

(2) INFORMATION FOR SEQ ID NO: 1236: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 78 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1236: BGBGGGCBGT BGCBBTGBGG BTGBCBGCGB GGCGTGCCGC GGBGBCCTTC BTGGTBCCTG 60 TGGBGBGGCT GTCGGBGG 78

(2) INFORMATION FOR SEQ ID NO: 1237: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 70 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1237: GGGTGTGGTG TCCGCTTGGC GGTTCTTTCG GGTGTTTCTT CTCTGGGTTG GCCTGCTGCT 60 CGTCGTGGTC 70

(2) INFORMATION FOR SEQ ID NO: 1238: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 71 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1238: GCTCCGCTCC CGGGTTCGTC TCGCTCTGTC GCCCCTTCCT TCCTTGTCGT GTTCCTCCCT 60 TCCTTGCCTC T 71

(2) INFORMATION FOR SEQ ID NO: 1239: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear EPI-109 420

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1239: GGGTGTGGTG TCCG 14

(2) INFORMATION FOR SEQ ID NO: 1240: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1240: CTTGGCGGTT CTTTCGGGTG 20

(2) INFORMATION FOR SEQ ID NO:1241: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1241: TTTCTTCTCT GGGTTGGC 18

(2) INFORMATION FOR SEQ ID NO: 1242: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1242: CTGCTGCTCG TCGTGGTC 18

(2) INFORMATION FOR SEQ ID NO: 1243: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1243: GCTCCGCTCC CGGGTTC 17

(2) INFORMATION FOR SEQ ID NO: 1244: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1244: GTCTCGCTCT GTCGCCC 17

(2) INFORMATION FOR SEQ ID NO: 1245: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1245: CTTCCTTCCT TGTC 14

(2) INFORMATION FOR SEQ ID NO: 1246: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1246: GTGTTCCTCC CTTCCTTGCC TCT 23

(2) INFORMATION FOR SEQ ID NO: 12 7: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1247: GTTCBTGGTG GCTBGGTGGG GC 22 EPI-109 421

(2) INFORMATION FOR SEQ ID NO: 1248: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1248: GCTGCCCGGC GGGGTGTGCG CTTGGC 26

(2) INFORMATION FOR SEQ ID NO: 1249: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1249: GCTCCCGTGC TCGGTTCTCT GTCTCCCGGT 30

(2) INFORMATION FOR SEQ ID NO: 1250: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1250: CCCCCTTTGC CTGGCGTCTC GG 22

(2) INFORMATION FOR SEQ ID NO: 1251: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH r 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1251: GCCTTCGTCC TCTTCCTCTT CTTCCTTCC 29

(2) INFORMATION FOR SEQ ID NO: 1252: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 43 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1252: GCTCCGTGGG GGCTGCTTGG TGGGGGCCTG TGCCTCGGGG TCC 43

(2) INFORMATION FOR SEQ ID NO: 1253: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1253: CGGGGCTTCT GGCCCTTGCC 20

(2) INFORMATION FOR SEQ ID NO: 1254: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1254: GTTCATGGTG GCTAGGTGGG GC 22

(2) INFORMATION FOR SEQ ID NO: 1255: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1255: GGGGTGGGTB GGCCGTGTCT GGGG 24

(2) INFORMATION FOR SEQ ID NO: 1256: O 00/09525

EPI-109 422

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1256: GTTGGCCBTG TTGGTTGCC 19

(2) INFORMATION FOR SEQ ID NO: 1257: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1257: TCTTGGTGGT GCGCCGGGC 19

(2) INFORMATION FOR SEQ ID NO: 1258: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 47 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1258: GCGTCTTGGC TTTCTTCTCC TTCGGGCCCT CGGGCCGGTG CTTGTGG 47

(2) INFORMATION FOR SEQ ID NO: 1259: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 38 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1259: GCTCCTCCCG GGCGGCCTCC CCGGGCGGGG GCTTCTTG 38

(2) INFORMATION FOR SEQ ID NO: 1260: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1260: GCGCTGGCGG GGGGGCCTCC TCC 23

(2) INFORMATION FOR SEQ ID NO: 1261: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 37 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1261: GCTCTGTGGC TGGGCGTTCC TTGGTGTTCT GGGTGGC 37

(2) INFORMATION FOR SEQ ID NO.-1262: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1262: TGGCGGGCGT GGTGGCCTCT GTGGTGG 27

(2) INFORMATION FOR SEQ ID NO: 1263: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1263: GGGCCCGCGG CTGCBGGGG 19

(2) INFORMATION FOR .SEQ ID NO: 1264: (i) SEQUENCE CHARACTERISTICS: EPI-109 423

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1264: TTGCCTGTCT GCTTCGTC 18

(2) INFORMATION FOR SEQ ID NO: 1265: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1265: CTTTGCGCTC CCGGGCCGCC 20

(2) INFORMATION FOR SEQ ID NO: 1266: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1266: GGGGTGGGTA GGCCGTGTCT GGGG 24

(2) INFORMATION FOR SEQ ID NO: 1267: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1267: GTTGGCCATG TTGGTTGCC 19

(2) INFORMATION FOR SEQ ID NO: 1268: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1268: GGGCCCGCGG CTGCAGGGG 19

(2) INFORMATION FOR SEQ ID NO: 1269: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1269: CGGTTTCCTT TGCGGTC 17

(2) INFORMATION FOR SEQ ID NO: 1270: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1270: TTGGCCCGGG CTCCGGGTG 19

(2) INFORMATION FOR SEQ ID NO: 1271: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1271: CCCGCCCGCC CGCCGGCCGC CGC 23

(2) INFORMATION FOR SEQ ID NO: 1272: (i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single EPI-109 424

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1272: CCCGCCGGGC TGTCCCCGCC CCGCCCC 27

(2) INFORMATION FOR SEQ ID NO: 1273: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1273: GGCCCGGGGC GCGGGGG 17

(2) INFORMATION FOR SEQ ID NO: 1274: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1274: CGGCCCTCCC GCCCCTCTGG 20

(2) INFORMATION FOR SEQ ID NO: 1275: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1275: GCCGGCGCGG GCGTCGG 17

(2) INFORMATION FOR SEQ ID NO: 1276: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 37 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1276: CCGCTCGCGC CTGGGGTTCC CTCTCCTCCC CCTGTGC 37

(2) INFORMATION FOR SEQ ID NO: 1277: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1277: GCCTGCCTCT TGCTCTTC 18

(2) INFORMATION FOR SEQ ID NO: 1278: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1278: TGCGTCCGCT GCCTTCTCCC 20

(2) INFORMATION FOR SEQ ID NO: 1279: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1279: CTCTCCTCGG CCGTTGCCTG TGC 23

(2) INFORMATION FOR SEQ ID NO:1280: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1280: TGTCCGTCCT GTCGCCCTTC CGTGGTGC 28 EPI-109 425

(2) INFORMATION FOR SEQ ID NO: 1281: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1281: TGTTGTCTCT TCTGCCCTC 19

(2) INFORMATION FOR SEQ ID NO: 1282: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: sin'gle

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1282: GGTGTGCTGG TGCTGGTGGT GGTG 24

(2) INFORMATION FOR SEQ ID NO: 1283: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1283: CCTCTGCCCG TGCTCGCC 18

(2) INFORMATION FOR SEQ ID NO: 1284: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH:- 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1284: CTGCCTGGGC TGGCCTCTTC GGGT 24

(2) INFORMATION FOR SEQ ID NO: 1285: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear ^•

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1285: GTGGCTTTGG GGCTCTCTTG GTTGCCCTTT 30

(2) INFORMATION FOR SEQ ID NO: 1286: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 35 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1286: CTTCTCGTGG TGCCTCTCCT CCCTGGCTTG GTCGT 35

(2) INFORMATION FOR SEQ ID NO: 1287: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1287: TGTCTGGGGT GGTGCTCCTC TCCC 24

(2) INFORMATION FOR SEQ ID NO: 1288: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1288: TTTCCCTGCT GGCCGTTTGT 20

(2) INFORMATION FOR SEQ ID NO: 1289: (i) SEQUENCE CHARACTERISTICS: EPI-109 426

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1289: CCTGTTTTCT GTCTTCCTCT 20

(2) INFORMATION FOR SEQ ID NO: 1290: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1290: TTCCTCCTGT TTCTCCGT 18

(2) INFORMATION FOR SEQ ID NO: 1291: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1291: TTGGCTTGCT GCTTGCGGGG CTGTCTCC 28

(2) INFORMATION FOR SEQ ID NO: 1292: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1292: CTTGCCCCTG TGGGCTTTCC C 21

(2) INFORMATION FOR SEQ ID NO: 1293: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1293: TGGTCCGGTC TTCTCCTTGG GGGTC 25

(2) INFORMATION FOR SEQ ID NO: 1294: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1294: GCCCTTCTTG GTGGGCTG . 18

(2) INFORMATION FOR SEQ ID NO: 1295: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1295: GCTCGTCTGT CTTTTTCCTT CC 22

(2) INFORMATION FOR SEQ ID NO: 1296: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1296: TGGGGGTGGC CGTTGTGGGC GGTGTGGTCC GCCT 34

(2) INFORMATION FOR SEQ ID NO: 1297: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single EPI-109 427

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1297: TGCCTCTGCT GGTCTTTC 18

(2) INFORMATION FOR SEQ ID NO: 1298: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1298: GTGCTCCGGT GGCTTTTT 18

(2) INFORMATION FOR SEQ ID NO: 1299: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1299: GCTTGTGTGC TCTGCTGTCT CTG 23

(2) INFORMATION FOR SEQ ID NO: 1300: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1300: TTCCTTCCGG TGGTTTCTTC CTGGCTCTTG TCCT 34

(2) INFORMATION FOR SEQ ID NO: 1301: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1301: TTCTCTTGGC CCTTGGCCC 19

(2) INFORMATION FOR SEQ ID NO: 1302: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1302: TGGCTCGGTG CTTCTGCCCC 20

(2) INFORMATION FOR SEQ ID NO: 1303: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1303: TGTTGTTGCG GCGCTC 16

(2) INFORMATION FOR SEQ ID NO: 1304: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1304: GGTTGGTGTG GCCCCTG 17

(2) INFORMATION FOR SEQ ID NO: 1305: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1305: TGGTGCTTCG TTTCC 15 EPI-109 428

(2) INFORMATION FOR SEQ ID NO:1306: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1306: CCCTCTTTCT CTTTGTTC 18

(2) INFORMATION FOR SEQ ID NO: 1307: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1307: GGGGGTTCTT GTGGC 15

(2) INFORMATION FOR SEQ ID NO: 1308: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1308: GGGCTGCTTG TCTCGTTCC 19

(2) INFORMATION FOR SEQ ID NO: 1309: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH:- 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1309: GGTCCBGCCB TGGGTCTGGG 20

(2) INFORMATION FOR SEQ ID NO: 1310: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1310: GGCTGGGCTG CBGGCTCCGG 20

(2) INFORMATION FOR SEQ ID NO: 1311: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1311: GCGGGCGGGT GCGGGCTGCG TGCTGGG 27

(2) INFORMATION FOR SEQ ID NO: 1312: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1312: GGCTGCCCCG CAGGCCCTGC 20

(2) INFORMATION FOR SEQ ID NO: 1313: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 115 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1313: GCBCCGCCTG GBGCCCTGGG GCCCCCCTGT CTTCTTGGGG BGCGCCTCCT CGGCCBGCTC 60 EPI-109 429

CBCGTCCCGG BTCBTGCTTT CBGTGCTCBT GGTGTCCTTT CCBGGGGBGB GBGGG 115

(2) INFORMATION FOR SEQ ID NO: 1314: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 331 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1314:

GCTGGTCCTC TGCTGTCCTT GCTGGTGCTC BTGGTGTCCT TTCCGCCCTG GGGCCCCCCT 60

GTCTTCTTGG GGCCTCTTCC CTCTGGGGGC CGTCTCTCTC CCTCTCTTGC GTCTCTCTCT 120

TTCTCTCTCT CTCTTCCCCT TTCCCGCTCT TTCTGTCTCG GTGTCTGGTT TTCTCTCTCC 180

GCTGGCTGCC TGTCTGGCCT GCGCTCTTGG CCTGTGCTGT TCCTCCTCCG GTTCCTGTCC 240

TCTCTGTCTG TCGCCCCCTC TGGGGTCTCC CTCTGGCGTG GTGGTCTTGT TGCTTGGGCT 300

GGGCTCCGTG TCTCCBGTGC TCBTGGTGTC C 331

(2) INFORMATION FOR SEQ ID NO: 1315: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 373 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1315:

GCTGBGGGBG CGTCTGCTGG CGCTGGTCCT CTGCTGTCCT TGCTGGTGCT CBTGGTGTCC 60

TTTCCGCCCT GGGGCCCCCC TGTCTTCTTG GGGCCTCTTC CCTCTGGGGG CCGTCTCTCT 120

CCCTCTCTTG CGTCTCTCTC TTTCTCTCTC TCTCTTCCCC TTTCCCGCTC TTTCTGTCTC 180

GGTGTCTGGT TTTCTCTCTC CGCTGGCTGC CTGTCTGGCC TGCGCTCTTG GCCTGTGCTG 240

TTCCTCCTCC GGTTCCTGTC CTCTCTGTCT GTCGCCCCCT CTGGGGTCTC CCTCTGGCGT 300

GGTGGTCTTG TTGCTTGGGC TGGGCTCCGT GTCTCCBGTG CTCBTGGTGT CCGCTGBGGG 360

BGCGTCTGCT GGC 373

(2) INFORMATION FOR SEQ ID NO:1316: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1316: GCCCCGTCTG CTGCTCCTCG TGCCG 25

(2) INFORMATION FOR SEQ ID NO: 1317: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear ^■

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1317: CCTCGTCCTT CATGGTACCG TCGGTGTGGT GGC 33

(2) INFORMATION FOR SEQ ID NO: 1318: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1318: CTCGGGTGGG CCGGTGGTG 19

(2) INFORMATION FOR SEQ ID NO: 1319: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1319: GGGCGCGCGC GCTCGCGT 18

(2) INFORMATION FOR SEQ ID NO: 1320: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 49 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear EPI-109 430

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1320: GGCTCCGGCT CTTCTTTCCC GGCTCCGTCG GCCCGGGGGC CTTGGTCTC 49

(2) INFORMATION FOR SEQ ID NO: 1321: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1321: CCTCGTCCTT CBTGGTBCCG 20

(2) INFORMATION FOR SEQ ID NO: 1322: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1322: CCCGTTCGCC TGGCGC 16

(2) INFORMATION FOR SEQ ID NO: 1323: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear ^•

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1323: GCGCTGCGGG TTCCTC 16

(2) INFORMATION FOR SEQ ID NO: 1324: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1324: GTGGGTTTCT CCCCGCCGTT CTC 23

(2) INFORMATION FOR SEQ ID NO: 1325: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1325: CGGTCTGTTG CCTTTGTGGG 20

(2) INFORMATION FOR SEQ ID NO:1326: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1326: CTTCTTGTCT TTTTGGCT 18

(2) INFORMATION FOR SEQ ID NO: 1327: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1327: GTTCTTTTCC TGCTTGGC 18

(2) INFORMATION FOR SEQ ID NO: 1328: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1328: GTCTTTTCCT TTCTT 15 EPI-109 431

(2) INFORMATION FOR SEQ ID NO: 1329: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1329: TGTGCTCGGT TGTGGGTC 18

(2) INFORMATION FOR SEQ ID NO: 1330: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1330: CGCTGGTCCT TTGCC 15

(2) INFORMATION FOR SEQ ID NO:1331: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1331: CTGTGTGTTT CTGCTG 16

(2) INFORMATION FOR SEQ ID NO: 1332: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH:- 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1332: CCCGTTCGCC TGGCGC . 16

(2) INFORMATION FOR SEQ ID NO: 1333: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1333: GCGCTGCGGG TTCCTC 16

(2) INFORMATION FOR SEQ ID NO: 1334: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1334: GTGGGTTTCT CCCCGCCGTT CTC 23

(2) INFORMATION FOR SEQ ID NO: 1335: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1335: CGGTCTGTTG CCTTTGTGGG 20

(2) INFORMATION FOR SEQ ID NO: 1336: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1336: CTTCTTGTCT TTTTGGCT 18

(2) INFORMATION FOR SEQ ID NO: 1337: (i) SEQUENCE CHARACTERISTICS: O 00/09525

EPI-109 432

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1337: GTTCTTTTCC TGCTTGGC 18

(2) INFORMATION FOR SEQ ID NO:1338: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1338: GTCTTTTCCT TTCTT 15

(2) INFORMATION FOR SEQ ID NO:1339: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1339: TGTGCTGGGT TGTGGGTC 18

(2) INFORMATION FOR SEQ ID NO:1340: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1340: CGCTGGTCCT TTGCC 15

(2) INFORMATION FOR SEQ ID NO: 1341: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1341: CTGTGTGTTT CTGCTG 16

(2) INFORMATION FOR SEQ ID NO:1342: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1342: GCGTCCGGTG GCCGCCGC 18

(2) INFORMATION FOR SEQ ID NO: 1343: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1343: GCCTCTCTCC TCTCCCC 17

(2) INFORMATION FOR SEQ ID NO: 1344: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1344: GTGGCCCTGT CGGGCGGG 18

(2) INFORMATION FOR SEQ ID NO: 1345: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single O 00/09 5

EPI-109 433

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1345: TCCTGCCGTC CTGTCTCCTT T 21

(2) INFORMATION FOR SEQ ID NO: 1346: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO.-1346: TCTTTTGCTG TCTTGT 16

(2) INFORMATION FOR SEQ ID NO: 1347: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1347: CTTCCCGTCT CTGCTTT 17

(2) INFORMATION FOR SEQ ID NO: 1348: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1348: GTCTGTCCTC CCCGTCTCCT CCC 23

(2) INFORMATION FOR SEQ ID NO: 1349: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1349: ACTGCTTCTC CCGGGG 16

(2) INFORMATION FOR SEQ ID NO: 1350: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1350: GCTTCCCCGG CTTC 14

(2) INFORMATION FOR SEQ ID NO: 1351: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1351: GGGTGGCCGG TGTCCCGGGC TCCGGCGCGG CGGC 34

(2) INFORMATION FOR SEQ ID NO: 1352: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1352: GGCTTCGGCT GC 12

(2) INFORMATION FOR SEQ ID NO: 1353: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1353: GGGTGGGTGG CGCGG 15 EPI-109 434

(2) INFORMATION FOR SEQ ID NO: 1354: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1354: GCTGCCGGGT CCGCGCGGCG CCTGGGCC 28

(2) INFORMATION FOR SEQ ID NO: 1355: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1355: CTTGTGCTGC TTTT 14

(2) INFORMATION FOR SEQ ID NO: 1356: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1356: TGCTTGTTCC GTTC 14

(2) INFORMATION FOR SEQ ID NO: 1357: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH:- 32 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1357: TGGCTGCTCC GGTCTGTGTT GTGGTTGTTT TG 32

(2) INFORMATION FOR SEQ ID NO: 1358: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1358: TTTCTTCTTG GGTGTGGG 18

(2) INFORMATION FOR SEQ ID NO: 1359: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1359: CCTTGCGGTT TTGG ^' 14

(2) INFORMATION FOR SEQ ID NO: 1360: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear .

' (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1360: CTGTGGGCCC TTTG 14

(2) INFORMATION FOR SEQ ID NO: 1361: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1361: GGGCCTTGGC TTCTGGCTC 19

(2) INFORMATION FOR SEQ ID NO: 1362: (i) SEQUENCE CHARACTERISTICS: EPI-109 435

(A) LENGTH: 125 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1362:

CATCCACATG ATTGCTTAGA TTTGTGCTGT ATCTCTCAGG ATTATCACTG ATTACACATC 60

CAACCAGTGC CAGCCAAAAG GATGCCCTGA GGCAAAGGGT TTCCATCTTG AGGCAAATTT 120

GAGGA 125

(2) INFORMATION FOR SEQ ID NO: 1363: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 125 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1363: CBTCCBCBTG BTTGCTTBGB TTTGTGCTGT BTCTCTCBGG BTTBTCBCTG BTTBCBCBTC 60 CBBCCBGTGC CBGCCBBBBG GBTGCCCTGB GGCBBBGGGT TTCCBTCTTG BGGCBBBTTT 120 GBGGB 125

(2) INFORMATION FOR SEQ ID NO: 1364: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1364: CGTGGTCGCT CCGC 14

(2) INFORMATION FOR SEQ ID NO: 1365: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1365: GTTTCTCTGG TTCCTCCG 18

(2) INFORMATION FOR SEQ ID NO: 1366: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1366: GTCCCGCGGG GTGCTG 16

(2) INFORMATION FOR SEQ ID NO: 1367: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1367: TCTGGTCGCT GTCGT 15

(2) INFORMATION FOR SEQ ID NO: 1368: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1368: GGCTTGGGTC TCCGGGCG 18

(2) INFORMATION FOR SEQ ID NO: 1369: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1369: GTTTCCTTCC TTTTCCGC 18 EPI-109 436

(2) INFORMATION FOR SEQ ID NO: 1370: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1370: GTCCTGTCGT GGCGCCTGGG GCTC 24

(2) INFORMATION FOR SEQ ID NO: 1371: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1371: TTCTTTTGTG GGCT 14

(2) INFORMATION FOR SEQ ID NO: 1372: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1372: CTTTGGTGGC TGTGGCTG 18

(2) INFORMATION FOR SEQ ID NO: 1373: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1373: TGGTCTCTGT GGTTG 15

(2) INFORMATION FOR SEQ ID NO: 1374: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1374: CTGCCCTGGG TCTGG 15

(2) INFORMATION FOR SEQ ID NO.-1375: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 46 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1375: GGGTGTGGCC TTGGGGCCGT CCTCTGGCTC CTCCTCGTGG GCCCCC 46

(2) INFORMATION FOR SEQ ID NO:1376: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 265 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1376:

GGGCTAAGAT GATCCACATC ACTACCACGT TGCCCACCAC AGAGGTCACC ACAATGACCG 60

TGTAGGCAGC TGCCCAAAGG ACAATTTGCC AGGCTGGTTG CACGAACTGA TTGGGTTCCG 120

AGGTGTTAGT GGAGATGTTT GGGGAGAGGT CTGAGTCCAC CGGGAGGACG TTATCCATTT 180

CGAAGCTAGG CGGTAAAGCC CTACTATCTG TACACAACCC CCCTCTGCAG CAGAGTCCTG 240

TCGTGGCGCC TGGGGCTCAG GGTCC 265

(2) INFORMATION FOR SEQ ID NO: 1377: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 265 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1377: EPI-109 437

GGGCTBBGBT GBTCCBCBTC BCTBCCBCGT TGCCCBCCBC BGBGGTCBCC BCBBTGBCCG 60

TGTBGGCBGC TGCCCBBBGG BCBBTTTGCC BGGCTGGTTG CBCGBBCTGB TTGGGTTCCG 120

BGGTGTTBGT GGBGBTGTTT GGGGBGBGGT CTGBGTCCBC CGGGBGGBCG TTBTCCBTTT 180

CGBBGCTBGG CGGTBBBGCC CTBCTBTCTG TBCBCBBCCC CCCTCTGCBG CBGBGTCCTG 240

TCGTGGCGCC TGGGGCTCBG GGTCC 265

(2) INFORMATION FOR SEQ ID NO: 1378: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1378: CGTTTTCTTC TCTC 14

(2) INFORMATION FOR SEQ ID NO: 1379: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1379: GCTGGTTTTC CTTTCC 16

(2) INFORMATION FOR SEQ ID NO: 1380: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1380: TGGCAGTGGG TGGGGGTGGG GGTGGGGTGG C 31

(2) INFORMATION FOR SEQ ID NO: 1381: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1381: TTCCTTGTTC CTGGGGGTGT CCT 23

(2) INFORMATION FOR SEQ ID NO: 1382: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1382: CTTGCTCTGG GCTTTTCT 18

(2) INFORMATION FOR SEQ ID NO: 1383: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1383: CCCCTTTTCC TTCC 14

(2) INFORMATION FOR SEQ ID NO: 1384: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear ^'

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1384: TGTCTGTTTT CCTGGGG 1

(2) INFORMATION FOR SEQ ID NO: 1385: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear EPI-109 438

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1385: CTCTCCTCTG TCTCTGTGT 19

(2) INFORMATION FOR SEQ ID NO: 1386: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1386: CCTTGCCCTG GCCC 14

(2) INFORMATION FOR SEQ ID NO: 1387: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1387: TCTTCCCTCT CCTGTCTCCT GT 22

(2) INFORMATION FOR SEQ ID NO: 1388: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1388: CCCTGTGTTC CGCCC 15

(2) INFORMATION FOR SEQ ID NO: 1389: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1389: GTCTTCCCTC TCCTG 15

(2) INFORMATION FOR SEQ ID NO: 1390: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear .

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1390: ACCTCCTTTT CCTCCG 16

(2) INFORMATION FOR SEQ ID NO: 1391: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1391: CTGGGTGGGG CCCTG 15

(2) INFORMATION FOR SEQ ID NO: 1392: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1392: CCTGTTCTCT GCTCCC 16

(2) INFORMATION FOR SEQ ID NO: 1393: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1393: TGGCTTGGGG TTTCTTCTG 19 EPI-109 439

(2) INFORMATION FOR SEQ ID NO: 1394: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1394: TGTGTCTTCT TCCTCTGTT 19

(2) INFORMATION FOR SEQ ID NO:1395: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1395: GGCTGGCTTT CTCCTTC 17

(2) INFORMATION FOR SEQ ID NO: 1396: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1396: TTTTGTCTTC CTGGG ^• 15

(2) INFORMATION FOR SEQ ID NO: 1397: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1397: TGCCCCTTCT TCCTTTCTTG GG 22

(2) INFORMATION FOR SEQ ID NO:1398: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1398: TCCTTGGTGC TTGGGCTGGG 20

(2) INFORMATION FOR SEQ ID NO:1399: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1399: CTGTGCGTCC GTCTGCTGG 19

(2) INFORMATION FOR SEQ ID NO:1400: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1400: GGGGCCGGGG TGGCTGGGCC CTGCTTGCCG C 31

(2) INFORMATION FOR SEQ ID NO: 1401: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1401: ACGACCCCGG GCCGACCCGA G 21

(2) INFORMATION FOR SEQ ID NO: 1402: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs EPI-109 440

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1402: GCTCGGGGGG CTGTGTTCTG GCGCTGGTGG G 31

(2) INFORMATION FOR SEQ ID NO: 1403: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1403: CTTGGGCCCC TCTGGGGGCT GGGTT 25

(2) INFORMATION FOR SEQ ID NO: 1404: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1404: TCCTGCTGCG CCTGGGCGCT G 21

(2) INFORMATION FOR SEQ ID NO: 1405: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1405: GCGTCTTGGG GTGC 14

(2) INFORMATION FOR SEQ ID NO: 1406: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1406: GGGGCCGGGG GGCCGGGGG 19

(2) INFORMATION FOR SEQ ID NO: 1407: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1407: GCCGCTGTTC GTGGGCCTGG G 21

(2) INFORMATION FOR SEQ ID NO: 1408: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1408: GGTGCCTGTG GCTGCC 16

(2) INFORMATION FOR SEQ ID NO:1409: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1409: GGTTGCCCCG GTTGGTGGC 19

(2) INFORMATION FOR SEQ ID NO: 1410: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear EPI-109 441

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1410: GCCGTCCTGC TGCCGGT 17

(2) INFORMATION FOR SEQ ID NO: 1411: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1411: CGTTGGCTGG GTCCCCCCGC 20

(2) INFORMATION FOR SEQ ID NO: 1412: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1412: CCGTTTCCTG GGGTCC 16

(2) INFORMATION FOR SEQ ID NO: 1413: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1413: GCGTGGGGTG CTCC 14

(2) INFORMATION FOR SEQ ID NO: 1414: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1414: GGTTCCTCGT GCCG 14

(2) INFORMATION FOR SEQ ID NO: 1415: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1415: CTGCTGCCTT GTCTTTCC 18

(2) INFORMATION FOR SEQ ID NO: 1416: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1416: GGCCGTGGCG GCGTGGTGGT CC 22

(2) INFORMATION FOR SEQ ID NO: 1417: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1417: GCCCCCCCTG GCCTTCTGCT C 21

(2) INFORMATION FOR SEQ ID NO: 1418: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear ^"

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1418: GGGGTCTGGC TGGT 14 O 00/09525

EPI-109 442

(2) INFORMATION FOR SEQ ID NO: 1419: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1419: TGCCGGTGCC CTTGGCGGC 19

(2) INFORMATION FOR SEQ ID NO: 1420: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO.-1420: GGTCTTCTTC CTGGTG 16

(2) INFORMATION FOR SEQ ID NO:1421: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear .

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1421: GCTCTGGGCC CGGCCGGTCT CGG 23

(2) INFORMATION FOR SEQ ID NO: 1422: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1422: GCGTCTCGTG TTCG 14

(2) INFORMATION FOR SEQ ID NO: 1423: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1423: CTCTTGTGCT GTTCCGGCCG 20

(2) INFORMATION FOR SEQ ID NO: 1424: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1424: CTCCTTCCTC TTCCGCCGCC 20

(2) INFORMATION FOR SEQ ID NO: 1425: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1425: GCCGCTCCCC GCCC 14

(2) INFORMATION FOR SEQ ID NO: 1426: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1426: GCTCGTCGCC CTGGCCC 1

(2) INFORMATION FOR SEQ ID NO: 1427: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs EPI-109 443

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1427: GGCCTCCTCC TGGCCGC 17

(2) INFORMATION FOR SEQ ID NO: 1428: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1428: TGTCTCGGGC GGCGGCCTTG GC 22

(2) INFORMATION FOR SEQ ID NO: 1429: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1429: GCTCCGTTTG GGGCTG 16

(2) INFORMATION FOR SEQ ID NO:1430: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1430: CCTCTGGCGC TTCC . 14

(2) INFORMATION FOR SEQ ID NO: 1431: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1431: GGCCCTCGGC CTGGGCGCTC 20

(2) INFORMATION FOR SEQ ID NO: 1432: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1432: TCTTCCGCCT GTGC 14

(2) INFORMATION FOR SEQ ID NO: 1433: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1433: TGGTGGCCCT CGTGG 15

(2) INFORMATION FOR SEQ ID NO: 1434: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1434: GCCCCTCCTG GCCTCCGGTG TCC 23

(2) INFORMATION FOR SEQ ID NO:1435: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear 00/09525

EPI-109 444

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1435: TGTGGTCCCC CGGCTGGT 18

(2) INFORMATION FOR SEQ ID NO: 1436: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1436: GGCCGGGCCG GTTGGGCGGG C 21

(2) INFORMATION FOR ^'SEQ ID NO: 1437: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1437: GTGGGCGCCG GCGGGTCCTC C 21

(2) INFORMATION FOR SEQ ID NO: 1438: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1438: GGGCTGCCCT TCTCC 15

(2) INFORMATION FOR SEQ ID NO: 1439: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1439: GCCGGGGGTC CCGC 14

(2) INFORMATION FOR SEQ ID NO: 1440: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1440: GCTCCTGCTG TTCCCTGGGC TCTTCTGCC 29

(2) INFORMATION FOR SEQ ID NO: 1441: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1441: TCTCTCCTGG GTGGGTGCTG GGTGCCG 27

(2) INFORMATION FOR SEQ ID NO: 1442: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1442: GGGTCTCCGG GCTTG 15

(2) INFORMATION FOR SEQ ID NO: 1443: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1443: CCCCGCGCTG CTGGGCGTTC TGC 23 O 00/09525

EPI-109 445

(2) INFORMATION FOR SEQ ID NO: 1444: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1444: GGTCTTGGGG TTGTC 15

(2) INFORMATION FOR SEQ ID NO: 1445: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1445: TGTGGCCCCG CTCG 14

(2) INFORMATION FOR SEQ ID NO:1446: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1446: TGTCGCCCTC CGTCGCC 17

(2) INFORMATION FOR SEQ ID NO: 1447: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1447: CGTCGCCGGC CTCGTCC 17

(2) INFORMATION FOR SEQ ID NO: 1448: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1448: CCTCCTGGGT GCGC 14

(2) INFORMATION FOR SEQ ID NO: 1449: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1449: GGCGGGCTGG TCCT 14

(2) INFORMATION FOR SEQ ID NO: 1450: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1450: GGCGTTTTGC TCCTTCCTGG 20

(2) INFORMATION FOR SEQ ID NO: 1451: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1451: CTGCCTCCCC GGGGT 15

(2) INFORMATION FOR SEQ ID NO: 1452: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs O 00/09525

EPI-109 446

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1452: TTCTGCTGCT TGCTG 15

(2) INFORMATION FOR SEQ ID NO: 1453: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1453: CTTCTTTCCC GTCTCC 16

(2) INFORMATION FOR SEQ ID NO: 1454: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1454: CTTCTTTCCC GTCTCC 16

(2) INFORMATION FOR SEQ ID NO: 1455: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO.-1455: TTTTTGCCTC TTTG 14

(2) INFORMATION FOR SEQ ID NO: 1456: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1456: GGTTCCTGTT GTTTCT 16

(2) INFORMATION FOR SEQ ID NO: 1457: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1457: GGCCTGCTTG GTGGCG 16

(2) INFORMATION FOR SEQ ID NO: 1458: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1458: GCTTGTGCGT TTCC 14

(2) INFORMATION FOR SEQ ID NO:1459: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 36 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1459: TCTCTCTTCT CTTGGGTCTC CGCTTCTCGT CCTGCC 36

(2) INFORMATION FOR SEQ ID NO: 1460: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear EPI-109 447

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1460: TTTTCCTGTC TCTGTCGC 18

(2) INFORMATION FOR SEQ ID NO: 1461: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1461: GCCGTTCCTC CTCC 14

(2) INFORMATION FOR SEQ ID NO: 1462: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1462: GGCGTCCTCC TGCCC 15

(2) INFORMATION FOR SEQ ID NO: 1463: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1463: TGTGCTGTTT GCCTCGG 17

(2) INFORMATION FOR SEQ ID NO: 1464: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1464: GTGGTGCGGG TCCC ^' 14

(2) INFORMATION FOR SEQ ID NO: 1465: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1465: GGTGCTCCCC CGGC 14

(2) INFORMATION FOR SEQ ID NO: 1466: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1466: GGGCCGGCTG GTTGCCTGGG C 21

(2) INFORMATION FOR SEQ ID NO: 1467: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1467: CTGTCTGGTG GGGTGTGGGG CC 22

(2) INFORMATION FOR SEQ ID NO: 1468: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1468: GCTGGGTTGG GGGTGTGGTG 20 EPI-109 448

(2) INFORMATION FOR SEQ ID NO: 1469: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1469: GGCTCTTCTG TGGCC 15

(2) INFORMATION FOR SEQ ID NO: 1470: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1470: TGTGGGGCTG TTGGTG 16

(2) INFORMATION FOR SEQ ID NO: 1471: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1471: TCTCTGTGGG CGTGTG 16

(2) INFORMATION FOR SEQ ID NO: 1472: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1472: CTGGGTCTTG GGGCTTC 17

(2) INFORMATION FOR SEQ ID NO:1473: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1473: CTCCCTTGTG CTGGG 15

(2) INFORMATION FOR SEQ ID NO: 1474: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1474: TGCGGCCTCC CCGC 14

(2) INFORMATION FOR SEQ ID NO: 1475: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1475: CCCCCTTCTG GGCC 14

(2) INFORMATION FOR SEQ ID NO: 1476: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1476: GGTGGCCTGG CTCCTTGTGG 20

(2) INFORMATION FOR SEQ ID NO: 1477: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs EPI-109 ₄₄9

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1477: GCGCTTCTGG CTCTTG 16

(2) INFORMATION FOR SEQ ID NO: 1478: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1478: CCCTGTCCTT CTTCGCCTCG T 21

(2) INFORMATION FOR SEQ ID NO: 1479: (i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1479: GGCTGCTGGG CTGC 14

(2) INFORMATION FOR SEQ ID NO: 1480: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1480: GTTGGGCTTG GCCGGGG 17

(2) INFORMATION FOR SEQ ID NO: 1481: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1481: CTGCCCGGTG CCTCC 15

(2) INFORMATION FOR SEQ ID NO: 1482: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1482: TCTTGGCTGG TCCCTCGT 18

(2) INFORMATION FOR SEQ ID NO: 1483: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1483: TGTCCTTGGG CCCC 14

(2) INFORMATION FOR SEQ ID NO: 1484: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1484: GCTCCCGCTG CTCGGCCTCC GT 22

(2) INFORMATION FOR SEQ ID NO: 1485: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear O 00/09525

EPI-109 450

(xi) SEQUENCE DESCRIPTION: SEQ ID NO.-1485: GTTCTTTGGC CTCTTGCTCC 20

(2) INFORMATION FOR SEQ ID NO: 1486: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1486: GCCTGCTGTC TTGTCC 16

(2) INFORMATION FOR SEQ ID NO: 1487: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1487: CGTCCCCTCC TCGCTTGCGT TTC 23

(2) INFORMATION FOR SEQ ID NO: 1488: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1488: CCTCTTCCTT GTCTTCCA 18

(2) INFORMATION FOR SEQ ID NO: 1489: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1489: GGCCTTCCTC CGCTTCCGCT GC 22

(2) INFORMATION FOR SEQ ID NO: 1490: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1490: TGGGGCCCGC GCCGG 15

(2) INFORMATION FOR SEQ ID NO:1491: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1491: GGGGGCGCTC GGCTCCGCGG CTTCCTCCCC GG 32

(2) INFORMATION FOR SEQ ID NO: 1492: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1492: CTGGGGGGTC CTGG 14

(2) INFORMATION FOR SEQ ID NO: 1493: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid 00/09525 451

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1493: TCTCCGGGGC CTGCGGCTCG C 21

(2) INFORMATION FOR SEQ ID NO: 1494: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1494: GGGCTCGGGG CTGCGTGCGC C • 21

(2) INFORMATION FOR SEQ ID NO: 1495: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1495: GCGCGCGGCG TCCGCGGTG 19

(2) INFORMATION FOR SEQ ID NO: 1496: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1496: GGTGGCGCTG TCCCGCC 17

(2) INFORMATION FOR SEQ ID NO: 1497: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1497: GTGGTGTGTC TCCGTTCTCG TCCTGCGCCG TC 32

(2) INFORMATION FOR SEQ ID NO:1498: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1498: CTGGTCTGCC CGTGG 15

(2) INFORMATION FOR SEQ ID NO: 1499: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1 99: GGTCCTGGGC GTGGTGG 1₇

(2) INFORMATION FOR SEQ ID NO: 1500: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1500: GGGGCGTCTG GTGC 1₄ EPI-109 452

(2) INFORMATION FOR SEQ ID NO: 1501: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1501: CTCGTCTGCC CCGTG 15

(2) INFORMATION FOR SEQ ID NO: 1502: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1502: GGGCTTCGGG CTCGG 15

(2) INFORMATION FOR SEQ ID NO: 1503: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1503: GGCTGTTCGT CCCCCCTGCC GCTCTGTGGC CTCC 34

(2) INFORMATION FOR SEQ ID NO: 1504: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1504: GGGGCTCCTC GTTTTC 16

(2) INFORMATION FOR SEQ ID NO: 1505: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1505: GCTGCTTCGG GTGTCCTTCT C 21

(2) INFORMATION FOR SEQ ID NO: 1506: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1506: GGCGTGTGGC CCCGG 15

(2) INFORMATION FOR SEQ ID NO: 1507: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1507: GTCCCGGCCC TGCTGGGCTG GGCGGGGTC 29

(2) INFORMATION FOR SEQ ID NO: 1508: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1508: GCTGCCCTGG GCTTCTGGCC CGTCT 25 O 00/0 52

EPI-109 453

(2) INFORMATION FOR SEQ ID NO: 1509: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1509: GGTTGTCTGT CGGT 14

(2) INFORMATION FOR SEQ ID NO: 1510: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1510: GCTTGTCTCG GGTTTCTGG 19

(2) INFORMATION FOR SEQ ID NO: 1511: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1511: CCTCTGTGCT GGGC 14

(2) INFORMATION FOR SEQ ID NO: 1512: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO.-1512: GCTTCTCTGC CTCCTGCTCC 20

(2) INFORMATION FOR SEQ ID NO: 1513: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1513: GCCCTCCTGG TGGCTC 16

(2) INFORMATION FOR SEQ ID NO: 1514: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1514: GGCTGGGGGT GCCCGTGCG 19

(2) INFORMATION FOR SEQ ID NO: 1515: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear ^■

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1515: GGGGTGGGTG TGGGGTGTT 19

(2) INFORMATION FOR SEQ ID NO: 1516: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1516: TTCGGGGTCC TCCCCTTCCC 20

(2) INFORMATION FOR SEQ ID NO: 1517: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs EPI-109 454

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1517: GTTTCATCTT GGCTTTATCC 20

(2) INFORMATION FOR SEQ ID NO: 1518: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1518: TCTCCCCTTG TTCCTCCCC 19

(2) INFORMATION FOR SEQ ID NO: 1519: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1519: TCTCCTGCTC TGGRGTCTCC TC 22

(2) INFORMATION FOR SEQ ID NO: 1520: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1520: TTCCCTCCCT CCCCTGCC 18

(2) INFORMATION FOR SEQ ID NO: 1521: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1521: GTGTTGTCTG TGGGTGTCC • 19

(2) INFORMATION FOR SEQ ID NO: 1522: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1522: GTTTCGCTCT TGTTGCCC 18

(2) INFORMATION FOR SEQ ID NO: 1523: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1523: TGGGCCCTTC CCTGCTGG 18

(2) INFORMATION FOR SEQ ID NO: 1524: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1524: GGGGGAGTTT CATCTTGG 18

(2) INFORMATION FOR SEQ ID NO: 1525: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear EPI-109 455

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1525: GGGGGBGTTT CBTCTTGGCT TT 22

(2) INFORMATION FOR SEQ ID NO: 1526: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1526: GGGGGBGTTT CBTCTTGGCT T 21

(2) INFORMATION FOR SEQ ID NO: 1527: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1527: GGGGGBGTTT CBTCTTGGCT 20

(2) INFORMATION FOR SEQ ID NO: 1528: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1528: GGGGGBGTTT CBTCTTGGC 19

(2) INFORMATION FOR SEQ ID NO: 1529: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1529: GGGGGBGTTT CBTCTTGG 18

(2) INFORMATION FOR SEQ ID NO: 1530: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1530: GGGGGBGTTT CBTCTTG 17

(2) INFORMATION FOR SEQ ID NO: 1531: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1531: GGGGGBGTTT CBTCTT 16

(2) INFORMATION FOR SEQ ID NO:1532: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1532: GGGGGBGTTT CBTCT 15

(2) INFORMATION FOR SEQ ID NO: 1533: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1533: GGGGGBGTTT CBTC 14 EPI-109 456

(2) INFORMATION FOR SEQ ID NO: 1534: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1534: GGGGGBGTTT CBT 13

(2) INFORMATION FOR SEQ ID NO: 1535: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1535: GGGGGBGTTT CB 12

(2) INFORMATION FOR SEQ ID NO: 1536: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1536: GGGGBGTTTC BTCTTGGCTT T 21

(2) INFORMATION FOR SEQ ID NO: 1537: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1537: GGGGBGTTTC BTCTTGGCTT 20

(2) INFORMATION FOR SEQ ID NO: 1538: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1538: GGGGBGTTTC BTCTTGGCT 19

(2) INFORMATION FOR SEQ ID NO: 1539: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1539: GGGGBGTTTC BTCTTGGC 18

(2) INFORMATION FOR SEQ ID NO:1540: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1540: GGGGBGTTTC BTCTTGG 17

(2) INFORMATION FOR SEQ ID NO: 1541: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1541: GGGGBGTTTC BTCTTG 16

(2) INFORMATION FOR SEQ ID NO: 1542: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs O 00/09525

EPI-109 457

(B) TYPE: nucleic acid

(C) STRANDEDNESS : single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1542: GGGGBGTTTC BTCTT 15

(2) INFORMATION FOR SEQ ID NO: 1543: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1543: GGGGBGTTTC BTCT 14

(2) INFORMATION FOR SEQ ID NO: 1544: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1544: GGGGBGTTTC BTC 13

(2) INFORMATION FOR SEQ ID NO: 1545: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1545: GGGGBGTTTC BT 12

(2) INFORMATION FOR SEQ ID NO: 1546: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1546: GGGBGTTTCB TCTTGGCTTT 20

(2) INFORMATION FOR SEQ ID NO: 1547: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1547: GGGBGTTTCB TCTTGGCTT 19

(2) INFORMATION FOR SEQ ID NO:1548: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1548: GGGBGTTTCB TCTTGGCT 18

(2) INFORMATION FOR SEQ ID NO: 1549: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1549: GGGBGTTTCB TCTTGGC 17

(2) INFORMATION FOR SEQ ID NO: 1550:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single 00/09525

EPI-109 458

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1550: GGGBGTTTCB TCTTGG 16

(2) INFORMATION FOR SEQ ID NO: 1551: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1551: GGGBGTTTCB TCTTG 15

(2) INFORMATION FOR SEQ ID NO: 1552: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1552: GGGBGTTTCB TCTT 14

(2) INFORMATION FOR SEQ ID NO: 1553: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1553: GGGBGTTTCB TCT 13

(2) INFORMATION FOR SEQ ID NO: 1554: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1554: GGGBGTTTCB TC 12

(2) INFORMATION FOR SEQ ID NO: 1555: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1555: GGBGTTTCBT CTTGGCTTT 19

(2) INFORMATION FOR SEQ ID NO: 1556: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1556: GGBGTTTCBT CTTGGCTT 18

(2) INFORMATION FOR SEQ ID NO: 1557: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1557: GGBGTTTCBT CTTGGCT 1₇

(2) INFORMATION FOR SEQ ID NO: 1558: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1558: GGBGTTTCBT CTTGGC 16 EPI-109 459

(2) INFORMATION FOR SEQ ID NO: 1559: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1559: GGBGTTTCBT CTTGG 15

(2) INFORMATION FOR SEQ ID NO: 1560: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1560: GGBGTTTCBT CTTG 14

(2) INFORMATION FOR SEQ ID NO: 1561: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1561: GGBGTTTCBT CTT ^• 13

(2) INFORMATION FOR SEQ ID NO: 1562: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1562: GGBGTTTCBT CT 12

(2) INFORMATION FOR SEQ ID NO: 1563: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1563: GBGTTTCBTC TTGGCTTT 18

(2) INFORMATION FOR SEQ ID NO: 1564: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1564: GBGTTTCBTC TTGGCTT 17

(2) INFORMATION FOR SEQ ID NO:1565: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1565: GBGTTTCBTC TTGGCT 16

(2) INFORMATION FOR SEQ ID NO:1566: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1566: GBGTTTCBTC TTGGC 15

(2) INFORMATION FOR SEQ ID NO: 1567: (i) SEQUENCE CHARACTERISTICS: EPI-109 460

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1567: GBGTTTCBTC TTGG 14

(2) INFORMATION FOR SEQ ID NO: 1568: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1568: GBGTTTCBTC TTG 13

(2) INFORMATION FOR SEQ ID NO: 1569: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1569: GBGTTTCBTC TT 12

(2) INFORMATION FOR SEQ ID NO:1570: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1570: BGTTTCBTCT TGGCTTT 17

(2) INFORMATION FOR SEQ ID NO: 1571: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1571: BGTTTCBTCT TGGCTT 16

(2) INFORMATION FOR SEQ ID NO: 1572: (l) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1572: BGTTTCBTCT TGGCTT 16

(2) INFORMATION FOR SEQ ID NO: 1573: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1573: BGTTTCBTCT TGGCT 15

(2) INFORMATION FOR SEQ ID NO: 1574: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1574: BGTTTCBTCT TGGC 14

(2) INFORMATION FOR SEQ ID NO: 1575: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear EPI-109 461

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1575: BGTTTCBTCT TGG 13

(2) INFORMATION FOR SEQ ID NO: 1576: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1576: BGTTTCBTCT TG 12

(2) INFORMATION FOR SEQ ID NO: 1577: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1577: GTTTCBTCTT GGCTTT 16

(2) INFORMATION FOR SEQ ID NO: 1578: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1578: GTTTCBTCTT GGCTT 15

(2) INFORMATION FOR SEQ ID NO: 1579: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1579: GTTTCBTCTT GGCT 14

(2) INFORMATION FOR SEQ ID NO: 1580: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1580: GTTTCBTCTT GGC 13

(2) INFORMATION FOR SEQ ID NO: 1581: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1581: GTTTCBTCTT GG 12

(2) INFORMATION FOR SEQ ID NO: 1582: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1582: TTTCBTCTTG GCTTT 15

(2) INFORMATION FOR SEQ ID NO: 1583: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1583: TTTCBTCTTG GCTT 14 O 00/09525

EPI-109 462

(2) INFORMATION FOR SEQ ID NO: 1584: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1584: TTTCBTCTTG GCT 13

(2) INFORMATION FOR SEQ ID NO: 1585: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1585: TTTCBTCTTG GC 12

(2) INFORMATION FOR SEQ ID NO: 1586: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear ^'

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1586: TTCBTCTTGG CTTT 14

(2) INFORMATION FOR SEQ ID NO: 1587: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1587: TTCBTCTTGG CTT 13

(2) INFORMATION FOR SEQ ID NO: 1588: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1588: TTCBTCTTGG CT 12

(2) INFORMATION FOR SEQ ID NO: 1589: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1589: TCBTCTTGGC TTT 13

(2) INFORMATION FOR SEQ ID NO:1590: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1590: TCBTCTTGGC TT 12

(2) INFORMATION FOR SEQ ID NO: 1591: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1591: GGGGGBGTTT CBTCTTGGCT TT 22

(2) INFORMATION FOR SEQ ID NO: 1592: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs EPI-109 463

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1592: GGGGBGTTTC BTCTTGGCTT T 21

(2) INFORMATION FOR SEQ ID NO: 1593: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1593: GGGBGTTTCB TCTTGGCTTT 20

(2) INFORMATION FOR SEQ ID NO: 1594: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1594: GGBGTTTCBT CTTGGCTTT 19

(2) INFORMATION FOR SEQ ID NO:1595: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1595: GBGTTTCBTC TTGGCTTT 18

(2) INFORMATION FOR SEQ ID NO: 1596: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1596: BGTTTCBTCT TGGCTTT 17

(2) INFORMATION FOR SEQ ID NO: 1597: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1597: GTTTCBTCTT GGCTTT 16

(2) INFORMATION FOR SEQ ID NO: 1598: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1598: TTTCBTCTTG GCTTT 15

(2) INFORMATION FOR SEQ ID NO: 1599: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1599: TTCBTCTTGG CTTT 14

(2) INFORMATION FOR SEQ ID NO: 1600: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear EPI-109 464

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1600: TCBTCTTGGC TTT 13

(2) INFORMATION FOR SEQ ID NO: 1601: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1601: CBTCTTGGCT TT 12

(2) INFORMATION FOR SEQ ID NO: 1602: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1602: GGGGGBGTTT CBTCTTGGCT T 21

(2) INFORMATION FOR SEQ ID NO: 1603: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1603: GGGGBGTTTC BTCTTGGCTT 20

(2) INFORMATION FOR SEQ ID NO: 1604: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1604: GGGBGTTTCB TCTTGGCTT 19

(2) INFORMATION FOR SEQ ID NO: 1605: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1605: GGBGTTTCBT CTTGGCTT 18

(2) INFORMATION FOR SEQ ID NO: 1606: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1606: GBGTTTCBTC TTGGCTT 17

(2) INFORMATION FOR SEQ ID NO: 1607: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1607: BGTTTCBTCT TGGCTT 16

(2) INFORMATION FOR SEQ ID NO: 1608: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1608: GTTTCBTCTT GGCTT 15 EPI-109 465

(2) INFORMATION FOR SEQ ID NO: 1609: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1609: TTTCBTCTTG GCTT 14

(2) INFORMATION FOR SEQ ID NO: 1610: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1610: TTCBTCTTGG CTT 13

(2) INFORMATION FOR SEQ ID NO: 1611: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1611: TCBTCTTGGC TT 12

(2) INFORMATION FOR SEQ ID NO: 1612: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1612: GGGGGBGTTT CBTCTTGGCT 20

(2) INFORMATION FOR SEQ ID NO: 1613: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1613: GGGGBGTTTC BTCTTGGCT 19

(2) INFORMATION FOR SEQ ID NO: 1614: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1614: GGGBGTTTCB TCTTGGCT 18

(2) INFORMATION FOR SEQ ID NO: 1615: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1615: GGBGTTTCBT CTTGGCT 17

(2) INFORMATION FOR SEQ ID NO: 1616: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1616: GBGTTTCBTC TTGGCT 16

(2) INFORMATION FOR SEQ ID NO: 1617: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs EPI-109 466

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1617: BGTTTCBTCT TGGCT 15

(2) INFORMATION FOR SEQ ID NO: 1618: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1618: GTTTCBTCTT GGCT 14

(2) INFORMATION FOR SEQ ID NO: 1619: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1619: TTTCBTCTTG GCT 13

(2) INFORMATION FOR SEQ ID NO:1620: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1620: TTCBTCTTGG CT 12

(2) INFORMATION FOR SEQ ID NO: 1621: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1621: GGGGGBGTTT CBTCTTGGC 19

(2) INFORMATION FOR SEQ ID NO: 1622: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1622: GGGGBGTTTC BTCTTGGC 18

(2) INFORMATION FOR SEQ ID NO: 1623: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1623: GGGBGTTTCB TCTTGGC 17

(2) INFORMATION FOR SEQ ID NO: 1624: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1624: GGBGTTTCBT CTTGGC 16

(2) INFORMATION FOR SEQ ID NO: 1625: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear EPI-109 467

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1625: GBGTTTCBTC TTGGC 15

(2) INFORMATION FOR SEQ ID NO: 1626: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1626: BGTTTCBTCT TGGC 14

(2) INFORMATION FOR SEQ ID NO: 1627: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1627: GTTTCBTCTT GGC 13

(2) INFORMATION FOR SEQ ID NO: 1628: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1628: TTTCBTCTTG GC 12

(2) INFORMATION FOR SEQ ID NO: 1629: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1629: GGGGGBGTTT CBTCTTGG 18

(2) INFORMATION FOR SEQ ID NO: 1630: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1630: GGGGBGTTTC BTCTTGG 17

(2) INFORMATION FOR SEQ ID NO: 1631: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1631: GGGBGTTTCB TCTTGG 16

(2) INFORMATION FOR SEQ ID NO: 1632: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1632: GGBGTTTCBT CTTGG 15

(2) INFORMATION FOR SEQ ID NO: 1633: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1633: GBGTTTCBTC TTGG 14 EPI-109 468

(2) INFORMATION FOR SEQ ID NO: 1634: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1634: BGTTTCBTCT TGG 13

(2) INFORMATION FOR SEQ ID NO: 1635: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1635: GTTTCBTCTT GG 12

(2) INFORMATION FOR SEQ ID NO:1636: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1636: GGGGGBGTTT CBTCTTG 17

(2) INFORMATION FOR SEQ ID NO: 1637: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1637: GGGGBGTTTC BTCTTG 16

(2) INFORMATION FOR SEQ ID NO: 1638: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1638: GGGBGTTTCB TCTTG 15

(2) INFORMATION FOR SEQ ID NO: 1639: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1639: GGBGTTTCBT CTTG 14

(2) INFORMATION FOR SEQ ID NO: 1640: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1640: GBGTTTCBTC TTG 13

(2) INFORMATION FOR SEQ ID NO: 1641: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1641: BGTTTCBTCT TG 12

(2) INFORMATION FOR SEQ ID NO: 1642: (l) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs EPI-109 469

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1642: GGGGGBGTTT CBTCTT 16

(2) INFORMATION FOR SEQ ID NO: 1643: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1643: GGGGBGTTTC BTCTT 15

(2) INFORMATION FOR SEQ ID NO: 1644: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1644: GGGBGTTTCB TCTT 14

(2) INFORMATION FOR SEQ ID NO: 1645: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1645: GGGBGTTTCB TCTT 14

(2) INFORMATION FOR SEQ ID NO: 1646: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1646: GGBGTTTCBT CTT 13

(2) INFORMATION FOR SEQ ID NO: 1647: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1647: GBGTTTCBTC TT 12

(2) INFORMATION FOR SEQ ID NO: 1648: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1648: GGGGGBGTTT CBTCT 15

(2) INFORMATION FOR SEQ ID NO: 1649: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1649: GGGGBGTTTC BTCT 14

(2) INFORMATION FOR SEQ ID NO: 1650: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear EPI-109 470

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1650: GGGBGTTTCB TCT 1₃

(2) INFORMATION FOR SEQ ID NO: 1651: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1651: GGBGTTTCBT CT 12

(2) INFORMATION FOR SEQ ID NO: 1652: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1652: GGGGGBGTTT CBTC 14

(2) INFORMATION FOR SEQ ID NO: 1653: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1653: GGGGBGTTTC BTC 13

(2) INFORMATION FOR SEQ ID NO: 1654: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1654: GGGBGTTTCB TC 12

(2) INFORMATION FOR SEQ ID NO: 1655: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1655: GGGGGBGTTT CBT 13

(2) INFORMATION FOR SEQ ID NO: 1656: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1656: GGGGBGTTTC BT 12

(2) INFORMATION FOR SEQ ID NO: 1657: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1657: GGGGGBGTTT CB 12

(2) INFORMATION FOR SEQ ID NO: 1658: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1658: TCTCCCCTTG TTCCTCCCC 19 O 00/09525

(2) INFORMATION FOR SEQ ID NO: 1659: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1659: TCTCCTGCTC TGGTGTCTCC TC 22

(2) INFORMATION FOR SEQ ID NO: 1660: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1660: TTCCCTCCCT CCCCTGCC 18

(2) INFORMATION FOR SEQ ID NO: 1661: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1661: GTGTTGTCTG TGGGTGTCC 19

(2) INFORMATION FOR SEQ ID NO: 1662: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1662: GTTTCGCTCT TGTTGCCC 18

(2) INFORMATION FOR SEQ ID NO: 1663: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1663: TGGGCCCTTC CCTGCTGG 18

(2) INFORMATION FOR SEQ ID NO: 1664: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1664: GCTGGTCCTC TGCTGTCCTT GCTG 24

(2) INFORMATION FOR SEQ ID NO: 1665: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1665: GTGCTCBTGG TGTCCTTTCC 20

(2) INFORMATION FOR SEQ ID NO: 1666: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1666: GCCCTGGGGC CCCCCTGTCT TCTTGGGG 28

(2) INFORMATION FOR SEQ ID NO: 1667: (l) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs EPI-109 472

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1667: CCTCTTCCCT CTGGGGGCCG 20

(2) INFORMATION FOR SEQ ID NO: 1668: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1668: TCTCTCTCCC TCTCTTGCGT CTCTC 25

(2) INFORMATION FOR SEQ ID NO: 1669: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1669: TCTTTCTCTC TCTCTCTTCC CC 22

(2) INFORMATION FOR SEQ ID NO: 1670: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1670: TTTCCCGCTC TTTCTGTCTC 20

(2) INFORMATION FOR SEQ ID NO: 1671: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1671: GGTGTCTGGT TTTCTCTCTC C 21

(2) INFORMATION FOR SEQ ID NO: 1672: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1672: GCTGGCTGCC TGTCTGGCCT GCGCTCTT 28

(2) INFORMATION FOR SEQ ID NO: 1673: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1673: GGCCTGTGCT GTTCCTCC 18

(2) INFORMATION FOR SEQ ID NO: 1674: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1674: TCCGGTTCCT GTCCTCTCTG TCTGTC 26

(2) INFORMATION FOR SEQ ID NO: 1675: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear EPI-109 473

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1675: GCCCCCTCTG GGGTCTCCCT CTGGC 25

(2) INFORMATION FOR SEQ ID NO: 1676: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1676: GTGGTGGTCT TGTTGCTT 18

(2) INFORMATION FOR SEQ ID NO: 1677: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1677: GGGCTGGGCT CCGTGTCTC 19

(2) INFORMATION FOR SEQ ID NO: 1678: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1678: CBGTGCTCBT GGTGTCC 17

(2) INFORMATION FOR SEQ ID NO: 1679: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1679: GCTGBGGGBG CGTCTGCTGG C 21

(2) INFORMATION FOR SEQ ID NO: 1680: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 329 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1680:

TGCTTTTCTT TTCTGGGCCT CTGTGGTCTG TTTTTTTCTG GCCCTGCTGG GGCGCTCTCC 60

GCCGCCCGCC TGGCTCCCGG BGCCCBTGBT GGGCBTGCCG TGGTTCTTGC CCTCCTTTGG 120

CTGCCGTGCC CGCTCCCCGG CCTCCTGGCG GGTGGCCGTT GGGCCCGTGT TCCCCTGGGG 180

CCTGGGGCTC CCTTCTCTCG CCCTTCTTGC TGGGCCTCTG CTGCTGCTGG TGCTGTGGCC 240

CCCGTACACC GAGGAGCCCA TGATGGGCAT GCCACAGACG ACAGGCGTBC BCCGBGGBGC 300

CCBTGBTGGG CBTGCCBCBG BCGBCBGGC 329

(2) INFORMATION FOR SEQ ID NO: 1681: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1681: CTGGGCCTC 9

(2) INFORMATION FOR SEQ ID NO: 1682: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1682: GCCGCCCGCC TG 12

(2) INFORMATION FOR SEQ ID NO: 1683: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid EPI-109 474

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO:1683: GCCCGCTCCC CGGC 14

(2) INFORMATION FOR SEQ ID NO: 1684: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1684: CBCCGBGGBG CCC 13

(2) INFORMATION FOR SEQ ID NO: 1685: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 304 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1685:

GGCGCCGTGC CGCGTCTTGG TGGCGGCGGG TTCGCGCCCG CGCGGGGCCC CTCCGGTCCG 60

TTCGCGCCCG CGCGGGGCCC CTCCGGTCCC GGGTCGGGGC CCCCCGCGGC CGCCTCGGGG 120

CTGGGGCGCT GGTGGCCGGG CCGCGCCTCC GCCTGCCGCT TCTGGCTGGG CCCCGGGCGC 180

CCCCTCCCCT CTTGCTCGGG TCCCCGTGAC AGCGCGTCCT GTGTCTCCAG CAGCATGGCC 240

GGGCCAGCTG GGCCCCBCBG CGCGTCCTGT GTCTCCBGCB GCBTGGCCGG GCCBGCTGGG 300

CCCC 304

(2) INFORMATION FOR SEQ ID NO: 1686: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1686: GCGCGTCCTG 10

(2) INFORMATION FOR SEQ ID NO: 1687: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1687: GCTGGGCCCC GG 12

(2) INFORMATION FOR SEQ ID NO: 1688: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1688: CGGGTCGGGG CCCCCC 16

(2) INFORMATION FOR SEQ ID NO: 1689: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1689: CGCGCCCGCG 10

(2) INFORMATION FOR SEQ ID NO: 1690: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 213 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1690:

ACAGAGCAGT GCTGTTGTTG GGCATCTTGC CTTCCCAGGG BCBGBGCBTG CTGTTGTTGG 60

GCBTCTTGCC TTCCCBGGGC CCTTTTCTGG TGGGGTGGTG CTGTTGTTGG GCTTTCTTCT 120

GTTCCCBCBG BGCBGTGCTG TTGTTGGGCB TCTTGCCTTC CCBGGGCCCT TTTCTGGTGG 180

GGTGGTGCTG TTGTTGGGCT TTCTTCTGTT CCC 213 EPI-109 475

(2) INFORMATION FOR SEQ ID NO: 1691: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1691: GBGCBTGC 8

(2) INFORMATION FOR SEQ ID NO: 1692: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1692: TTGTTGGGC 9

(2) INFORMATION FOR SEQ ID NO: 1693: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1693: TGCCTTCCCB GGG 13

(2) INFORMATION FOR SEQ ID NO: 1694: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 133 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1694:

TTTCCCCTGG GTCTTCCCTC CTGCTCTTTT TTCATTTGCT CTCCTATTAC TTTCTGTGTC 60

CATTTTTTCA TTAACCGAGC TGTBTTTGCT CTCCTBTTBC TTTCTGTGTC CBTTTTTTCB 120

TTBBCCGBGC TGT 133

(2) INFORMATION FOR SEQ ID NO: 1695: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi)' SEQUENCE DESCRIPTION: SEQ ID NO:1695: CCCCTGGG 8

(2) INFORMATION FOR SEQ ID NO: 1696: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1696: GCTCTCCTBT T 11

(2) INFORMATION FOR SEQ ID NO: 1697: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1697: CBTTBBCCGB GCTG 14

(2) INFORMATION FOR SEQ ID NO: 1698: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 299 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1698: GCCTGTGTCT GTCCTCCTGC TTCGTTCCTC TCGTTCCTGC TTGGTGCCCT TGCCGGTCCT 60 GCTCCTCCGG GCTGTGGGTC GTGGCCCTGG CTCCGGCTGG TGGGCTCCCC TGGCCTTCGC 120

TGGCTGGCGG CGTGCGGGTC TTGCTCTGGG CCTGGCTGTG GCCGTGGTTG GGGG.CTTCG 180 CTGCCTCCGT TTGGGTGGCT CTCTGAATAT TGACCTTCCT CCATGGCGGT CCT3CTTGGA 240 TTCTCCCGAT CTCTGBBTBT TGBCCTTCCT CCBTGGCGGT CCTGCTTGGB TTCTCCCGB 299

(2) INFORMATION FOR SEQ ID NO: 1699: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1699: GTCCTCCT 8

(2) INFORMATION FOR SEQ ID NO: 1700: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1700: TGTGTCTGTC CTCC 14

(2) INFORMATION FOR SEQ ID NO: 1701: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1701: GTGGCCCTGG C 11

(2) INFORMATION FOR SEQ ID NO: 1702: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1702: CGTGGTTGGG G 11

(2) INFORMATION FOR SEQ ID NO: 1703: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1703: TCTCTGBBTB TTGBCC 16

(2) INFORMATION FOR SEQ ID NO: 1704: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 378 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1704:

GCCTTTCCTG GTTCTCTTGT TGTTTTTGGG GTTTGGCTTA CAGTAGAGTA GGGGATTCCA 60

TGGCAGGAGC CATCTTCTTC ATGGACTCCT TCAAGGAGAC CTTAGGTTTC TGAGGGACTG 120

CTAACACGCC ATCTGGAGCB CBGTBGBGTB GGGGBTTCCB TGGCBGGBGC CBTCTTCTTC 180

BTGGBCTCCT TCBBGGBGBC CTTBGGTTTC TGBGGGBCTG CTBBCBCGCC BTCTGGBGCG 240

TTGTTTTTGG GGTTTGGCTT GCCTTTCCTG GTTCTCTTBC BGTBGBGTBG GGGBTTCCBT 300

GGCBGGBGCC BTCTTCTTCB TGGBCTCCTT CBBGGBGBCC TTBGGTTTCT GBGGGBCTGC 360

TBBCBCGCCB TCTGGBGC 378

(2) INFORMATION FOR SEQ ID NO: 1705: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1705: TGGBCTCC 8

(2) INFORMATION FOR SEQ ID NO: 1706: (l) SEQUENCE CHARACTERISTICS: EPI-109 477

(A) LENGTH: 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1706: CCBTCTGGB 9

(2) INFORMATION FOR SEQ ID NO: 1707: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1707: CTGCTBBCBC G 11

(2) INFORMATION FOR SEQ ID NO: 1708: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1708: GTTTTTGGGG TTTG 14

(2) INFORMATION FOR SEQ ID NO: 1709: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 279 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1709:

GCCTGTGTCT GTCCTCCTGC TTCGTTCCTC TCGTTCCTGC TTGGTGCCCT TGCCGGTCCT 60

GCTCCTCCGG GCTGTGGGTC CTCGCCCTGG CTCCGGCTGG TGGGCTCCCC TGGCCTTCGC 120

TGGCTGGCGG CGTGCCCCBG BBCGBGBCCC GGBCCGBCBG GCCGTGGTTG GGGGTCTTCG 180

CTGCCTCCGT TTGGGTGGCG ATCTCTGAAT ATTGACCTTC CATGGCGGTC CTGCTTGGAG 240

BTCTCTGBBT BTTGBCCTTC CBTGGCGGTC CTGCTTGGB 279

(2) INFORMATION FOR SEQ ID NO: 1710: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 291 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1710:

GCCTGTGTCT GTCCTCCTGC TTCGTTCCTC TCGTTCCTGC TTGGTGCCCT TGCCGGTCCT 60

GCTCCTCCGG GCTGTGGGTC CTCGCCCTGG CTCCGGCTGG TGGGCTCCCC TGGCCTTCGC 120

TGGCTGGCGG CGTGCCCCBG BBCGBGBCCC GGBCCGBCBG GCCGTGGTTG GGGGTCTTCG 180

CTGCCTCCGT TTGGGTGGCG ATCTCTGAAT ATTGACCTTC CATGGCGGTC CTGCTTGGAG 240

BTCTCTGBBT BTTGBCCTTC CBTGGCGGTC CTGCTTGGBT CGTTCCTCTC G 291

(2) INFORMATION FOR SEQ ID NO: 1711: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1711: BGBBCGBGBC 10

(2) INFORMATION FOR SEQ ID NO: 1712: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1712: TGBBTBTTGB 10

(2) INFORMATION FOR SEQ ID NO:1713: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 171 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single EPI-109 478

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1713: TCTCCCTTGG GCTCTGGCTC CTTCTCTCTC TCTCCCTCTC TCTCTGTCGC CTCCGCCCTG 60 GCTGCTGGGG TGGTGGTGCT TTTGTTCTTC CTTGCTGCCG CCCCGCTGCT TGTCTTCCTC 120 GCTCTGTCCC TCTCTCTCTG TBCTCCTCBG GCTCCBTCBT CTCCCTTGGG C 171

(2) INFORMATION FOR SEQ ID NO: 1714: (l) SEQUENCE CHA ACTERISTICS:

(A) LENGTH: 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1714: GGCTCTGGC 9

(2) INFORMATION FOR SEQ ID NO:1715: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 7 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1715: CCCTTGG 7

(2) INFORMATION FOR SEQ ID NO: 1716: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1716: TTTGTTCTTC C 11

(2) INFORMATION FOR SEQ ID NO: 1717: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 123 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1717:

CTTGCTCCTG GGGGCCTCCT GGTCCCTCCG GGTGTTCCCG GCGGGCCTGG CCTGGGGCBG 60

GGGCCGCGTB GGCGCGGCTC GCCBGGBCGG GCBGCGCCBG CBGCBGCBGB TTCBGCBTCC 120

TGG 123

(2) INFORMATION FOR SEQ ID NO:1718: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1718: GCTCCTGGGG GCCT 14

(2) INFORMATION FOR SEQ ID NO: 1719: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 1719: CGTBGGCGC 9

(2) INFORMATION FOR SEQ ID NO: 1720: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1720: TGGCCTGGGG 10

(2) INFORMATION FOR SEQ ID NO: 1721: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 132 base pairs

(B) TYPE: nucleic acid EPI-109 479

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1721:

CTTGCTCCTG GGGGCCTCCT GGTCCCTCTG GCTGTTCCCG GCCCTGGBCT GGGGCBGGGG 60

CCGCGTBGGC GCGGCTCGCC BGGBCGGGCB GCGCCBGCBG CBGCBGGCTC BGCBTCCTGG 120

CCBCGGBBTT CC 132

(2) INFORMATION FOR SEQ ID NO: 1722: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1722: CTCCTGGGGG CCTCCTG 17

(2) INFORMATION FOR SEQ ID NO:1723: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1723: BTCCTGGCCB CGGBBTTCC 19

(2) INFORMATION FOR SEQ ID NO: 1724: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 7 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1724: GTCCCTC 7

(2) INFORMATION FOR SEQ ID NO: 1725: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 180 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1725:

GGTGTGCGGG GCCTGGTGCC CCTGGGCCTC GGGTGCTGCC TGTGCGCTGC CTTCTTCTCC 60

TGGGTCCTCG CCGGGGCCCT TGCTGCCCTG GCTGTGCCCT GGGGGTCTGG GTTCGGCTGT 120

CCCCBGCBGG BCCBGTCCCB TCCBCBGCGT GTGBTGBGTB GCCBTTCTCC TGCBGCCGBG 180

(2) INFORMATION FOR SEQ ID NO: 1726: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1726: TTCTCCTGCB GCCGBG 16

(2) INFORMATION FOR SEQ ID NO: 1727: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1727: CTTGCTGCCC TGGCTGT 17

(2) INFORMATION FOR SEQ ID NO: 1728: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1728: TCTTCTCCTG G 11

(2) INFORMATION FOR SEQ ID NO: 1729: (l) SEQUENCE CHARACTERISTICS: (A) LENGTH: 101 base pairs EPI-109 480

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1729: GGGCGCGGGC GBGCBTCGCT TTGGGCTTTT CTCCTTTGGT TTGBGCGCCB GGBCCGCGCB 60 CBGCBGCBGG GCGCGGGCGB GCBTCGCBGC GGCGGGCBGG G 101

(2) INFORMATION FOR SEQ ID NO: 1730: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 7 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1730: GGCBGGG 7

(2) INFORMATION FOR SEQ ID NO: 1731: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1731: TCCTTTGGTT 10

(2) INFORMATION FOR SEQ ID NO: 1732: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 81 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1732: CCTCCTTCCT GGTCTGTCTG CCBGBCBBBT TTGGGBBGTG BBCBGTTTTG GBBCCBTGTT 60 TCCCBGTCTC TGBGCTGTGG C 81

(2) INFORMATION FOR SEQ ID NO: 1733: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1733: TTCTCCTTTG GTT 13

(2) INFORMATION FOR SEQ ID NO: 1734: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1734: TTTCTCCTTT GGTT 14

(2) INFORMATION FOR SEQ ID NO: 1735: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 156 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1735:

GCCCTGCTGC TCTTTCTGCT TCCCTTGGTG GGTTGGGCCG CTGGTTGTTC TGGGGTTCTT 60

GCTGCCCCTT CTGTCCCTGT TTGCTGGTGT CTGCGCCCCC BBCBGBBGBB GCBGBCBBBT 120

TTGGGBBGTG BBCBGTTTTG GBBCCBTGTT TCCTGT 156

(2) INFORMATION FOR SEQ ID NO: 1736: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 7 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1736: TTCCTGT η

(2) INFORMATION FOR SEQ ID NO: 1737: (l) SEQUENCE CHARACTERISTICS: EPI-109 481

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1737: CTCTTTCTGC T 11

(2) INFORMATION FOR SEQ ID NO: 1738: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1738: CCCCTTCTGT CCC 13

(2) INFORMATION FOR SEQ ID NO: 1739: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 272 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1739:

GCGCTCGGCC TGGTCCCGGG GGTCTCCTCT TGTTGTTGCT TGCGCCTCCT GCTGGGGGTC 60

CCTCTGTTCT TGTTTTGGGG GCGGGCCCGG CCGTTGTCTT GGTTTGGGGG TTTCCGTTGG 120

GGTTCTCCTG GCCCGGGCCT TGCCCGGCCG TGGTCCCGGC TTCGTTCCTG TCTCCGTCTC 180

GGCTCTTCTG GGGCCTTGCG CTGTCTTTGG TGGCBCCGTC CBGTGBTGGT GCGGTBCTTG 240

TCGCTGCBGC GCTCGGCCTG GTCCCGGBGB GC 272

(2) INFORMATION FOR SEQ ID NO: 1740: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1740: TCGGCCTGGT CCCGG 15

(2) INFORMATION FOR SEQ ID NO: 1741: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1741: TGGGGGTTTC CGTTG 15

(2) INFORMATION FOR SEQ ID NO: 1742: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1742: TGGTCCCGGB GBGC 14

(2) INFORMATION FOR SEQ ID NO: 1743: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 360 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1743:

GCGCGGGCCG GGGGCTGCTG GGGGTTGGCC CGGGGTGCCC CGCCGCTGGG TGCCCTCGTC 60

CTCTGCGGTC GTGTCTCCTG GCTCTGGTTC CCCGCTGCGC CCGTTGTCCT CTGGGGTGGC 120

CTTCGCTCCC GGGTCTGGTT CTTGTGTTGG GGGTCCCTTT TTGGGCCTGT TGTGGCGTGG 180

CTTGTGTGTT CGGTTTCTGC CCTGTCCTCC GGCGTCCCCG GBGCCTCCCC GGGGCBGGBT 240

GBCTTTTGBG GGGGBCBCBG BTGTCTGGGC BTTGCCBGGT CCTGGGBBCB GBGCCCCGBG 300

CBGGBCCBGG BGTGCGGGCB GCGCGGGCCG GGGGCTGCTG GGBGCCBTBG CGBGGCTGBG 360

(2) INFORMATION FOR SEQ ID NO: 1744: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single O 00/09525

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1744: GGGGGCTGCT GGG 13

(2) INFORMATION FOR SEQ ID NO: 1745: (l) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1745: TGTCCTCCGG CGTCCC 16

(2) INFORMATION FOR SEQ ID NO: 1746: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1746: GCCBTBGCGB GGCTGBG 17

(2) INFORMATION FOR SEQ ID NO:1747: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1747: CTCTGGGGTG GCCTTC 16

(2) INFORMATION FOR SEQ ID NO: 1748: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 242 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1748:

CCTCTTTTCT GTTTTTCCCC TCTGCCTTTG TTTGGGTTCG CTTCCTTTCT GCTTCTTCCC 60

TGTGTCTCCT GTCTCCGCTT TTTTCTTCGT CTTTGTTGTT TTCTCTTCCT TGCTGBGCBB 120

GBTBTCTBGB TTCTGGGGTG GTCTCGBTTT TBBBBGCTTG BGBBGCTGCB BBCBTTBTCC 180

BBBGTBTBTT TGBGGCTCCB BGGBTCBCGB CCBTCTTCCC BGGCBTTTTB BGTTGCTGTC 240 GT 242

(2) INFORMATION FOR SEQ ID NO.-1749: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 7 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1749: CTGTCGT 7

(2) INFORMATION FOR SEQ ID NO: 1750: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1750: TGCTTCTTCC 10

(2) INFORMATION FOR SEQ ID NO: 1751: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 249 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1751:

BBGTGBGBGC TGBGBGBBBC TGTGBBGCBB TCBTGBCTTC BBGBGTTCTT TTCBCCCGTT 60

CTTGGCTTCT TCTGTCCGTT GGCTTCTCGT TGTCCCTGTG GGCTTCTCGT TGTCCCCCCT 120

TCGGGGGCTG GTGGGGCCGT CCTTGCCTGC TGGGTTCTTG GCTTCTTCTG TCCGTTGGCT 180

TCTCGTTGTC CCTGTGGGCT TCTCGTTGTC CCCCCTTCGG GGGCTGGTGG GGCCGTCCTT 240

GCCTGCTGG 249 EPI-109 483

(2) INFORMATION FOR SEQ ID NO:1752: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1752: CCTTGCCTGC TGG 13

(2) INFORMATION FOR SEQ ID NO: 1753: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1753: GTTGTCCC 8

(2) INFORMATION FOR SEQ ID NO: 1754: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 77 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1754: TTTTCTCTTT CGCTTTCTTT TCGTCTCCTG TTCCTCCTTT TTTGCTGTTT TTTCTCCTTC 60 TTCTCTCCTT TCTTTTC 77

(2) INFORMATION FOR SEQ ID NO: 1755: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1755: TCCTTTCTTT TC 12

(2) INFORMATION FOR SEQ ID NO.-1756: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1756: CTCCTTTT 8

(2) INFORMATION FOR SEQ ID NO: 1757: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 77 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1757: TTTTCTCTTT CGCTTTCTTT TCGTCTCCTG TTCCTCCTTT TTTGCTGTTT TTTCTCCTTC 60 TTCTCTCCTT TCTTTTC

(2) INFORMATION FOR SEQ ID NO: 1758: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 1758: CCTTTCTTTT C 11

(2) INFORMATION FOR SEQ ID NO:1759: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1759: CTGTTCCTCC TTTT 1₄

(2) INFORMATION FOR SEQ ID NO: 1760: hPMUy 484

(ι) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 126 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1760: CTCTGTCTTG TTCTGGTCCT TCGTGGGGCT CTGTGTCGCG TGGGTGCGGC CGTGGCCGGC 60 GGBCCBGGBG TTGGBGCBGG BGCBGGBCGG GCBGGCGGCT CBTGTTTGGB TCGGCBGGBG 120 GCBCTC 126

(2) INFORMATION FOR SEQ ID NO: 1761: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1761: GGBGGCBCTC 10

(2) INFORMATION FOR SEQ ID NO: 1762: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1762: GTGGGGCTCT G 11

(2) INFORMATION FOR SEQ ID NO: 1763: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 648 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1763:

TCTGGGGTGT CCTGGCCTTC GTGGTTCCTC TTCCTTCGTT TGCCGTCCGC GGGGGCCCCC 60

GGGCCTGGCT GCGCTCCTGC CCCGCCTCTT TCCCGGGCTC TTGCGCTGGG GGGTGCTCCC 120

GTGTGTTTGC GCCCTCCTCC TGGTCGCGCT TGTCGTTTTG GGGCCGGCTT TGCCCGCCTC 180

CCGGCGCCTG GCCCGGCCTT CCTGGGCTGC GTGCGCGTTC TGTTCTTCTT CCTGGCTCTG 240

GGGTGTCCTG GCCTTCGTGG TTCCTCTTCC TTCGTTTGCC GTCCGCGGGG GCCCCCGGGC 300

CTGGCTGCGC TCCTGCCCCG CCTCTTTCCC GGGCTCTTGC GCTGGGGGGT GCTCCCGTGT 360

GTTTGCGCCC TCCTCCTGGT CGCGCTTGTC GTTTTGGGGC CGGCTTTGCC CGCCTCCCGG 420

CGCCTGGCCC GGCCTTCCTG GGCTGCGTGC GCGTTCTGTT CTTCTTCCTG GCGCAGGAGA 480

CAGGGCAGGG CGATCAGGAG CAGCGTGAGC CAAAGGAGGA CCATCGGGAA CGCAGCTCCG 540

GAACGCAGGA CAGAGGTGCC GCBGGBGBCB GGGCBGGGCG BTCBGGBGCB GCGTGBGCCB 600

BBGGBGGBCC BTCGGGBBCG CBGCTCCGGB BCGCBGGBCB GBGGTGCC 648

(2) INFORMATION FOR SEQ ID NO: 1764: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1764: GBGGTGCC 8

(2) INFORMATION FOR SEQ ID NO: 1765: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 7 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1765: GCCCCGC η

(2) INFORMATION FOR SEQ ID NO: 1766: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 88 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1766: CTCTGGTTGG CTTCCTTCGC CGGCBCBTGC TBGCBGGBBG BBCBGBGGGG GBBGCBGTTG 60 GGBGGTGBGB CCCBTTBBTB GGTGTCGB 88 EPI-109 485

(2) INFORMATION FOR SEQ ID NO: 1767: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1767: GCCGGCBCB 9

(2) INFORMATION FOR SEQ ID NO: 1768: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 7 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1768: TTCCTTC 7

(2) INFORMATION FOR SEQ ID NO: 1769: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 562 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1769:

TCTGCCCTGT CCGCCGGCTC TTCGGTGGCT CGGCCCCGCT CCTTGTCTTG CCGCGGGTTG 60

GTTCCTGGGC CTGGTTCTTG CGGGCGTTTC GGTCTGCTGG CTGGTCTGGG CCCGCGGTGC 120

GGCGGGTGGC TTGCTGTTCT GCCTGGGCTC TCCCCTCTCC TCCTTTTCTC CCTTCCTCTG 180

TCTTGCCTCC TTCCTCTGGG TCCTCTTGGC CTGGGCGCTC TTCCCCTCGG GCGGCTGCGG 240

GCGCTCGTGC TGCCTGGTCC GCTCCCTGGG GGTGCTCCTT CCCTTTCCCC GCTCGTGGGG 300

TTTGCGGGGC TGGGCTGCCC TGGGGGGTCT GGGCCTTTTG GGGTCGGCTG GCTGCTGCTT 360

CGGGCCGCCT GGGCTTCCCT GTGCCCCTTT CCTCTGCTGG GTCCCCCTCC CGTTCCAAGC 420

TGCACCGCAC AGACCGGCGC TACAGGACAG AGCCAGGCAA GCACCCATGG GGATCCAGGC 480

CCAGCTGTTC CBBGCTGCBC CGCBCBGBCC GGCGCTBCBG GBCBGBGCCB GGCBBGCBCC 540

CBTGGGGBTC CBGGCCCBGC TG 562

(2) INFORMATION FOR SEQ ID NO: 1770: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 7 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 1770: TCTGCGC 7

(2) INFORMATION FOR SEQ ID NO: 1771: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1771: CCTGCTCCTG GGG 13

(2) INFORMATION FOR SEQ ID NO: 1772: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 257 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1772:

TCCCTGTTTC CCCCCTTTCG TTCTGCGTTT GCCTTTGGCG TTTTTTGTTT GTTTTCTCTC 60

TCCGTCTTTC TTCTCCCCTG TGGGBBTTTC TGTGGGGBTG GCBTBCBCGT BGGCBGCTCC 120

BBGBGCTBGC BBBCTCBBBT GCBGBBGCBT CCTCBTGGCT CTGBBBCGGT GGGAATTTCT 180

GTGGGGBTGG CATACACGTA GGCAGCTCCA AGAGCTAGCA AACTCAAATG CAGAAGCATC 240

CTCATGGCTC TGAAACG 257

(2) INFORMATION FOR SEQ ID NO: 1773: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1773: GCCCCGGG Q EPI-109 486

(2) INFORMATION FOR SEQ ID NO: 1774: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1774: GGGTTTCT 8

(2) INFORMATION FOR SEQ ID NO:1775: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1775: GTGGGGBTGG C 11

(2) INFORMATION FOR SEQ ID NO: 1776: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1776: CCBBGBGCTB GC 12

(2) INFORMATION FOR SEQ ID NO: 1777: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 89 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1777: GTGGGAATTT CTGTGGGGBT GGCATACACG TAGGCAGCTC CAAGAGCTAG CAAACTCAAA 60 TGCAGAAGCA TCCTCATGGC TCTGAAACG 89

(2) INFORMATION FOR SEQ ID NO: 1778: (l) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 249 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1778:

CTCAGTGGCC CCCAAAAGGA TGAGTAATAC ATGCGCCACG ATGATCATAT CCTTTTTACT 60

ATGAGGCCGT GTCTGTCGTG TCTTTCCTTT GCTCTTGGTG TGTCTTTGCT GTGCCCTGCC 120

TCTCTGCCCG TGTCTGTCGT GTCTTTCCTT TGCTCTTGGT GTGTCTTTGC TGTGCCCTGC 180

CTCTCTGCCC GTGTCTGTCG TGTCTTTCCT TTGCTCTTGG TGTGTCTTTG CTGTGCCCTG 240

CCTCTCTGC 249

(2) INFORMATION FOR SEQ ID NO: 1779: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 7 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1779: CCGTGTC η

(2) INFORMATION FOR SEQ ID NO: 1780: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1780: GCCCTGCC ₈

(2) INFORMATION FOR SEQ ID NO: 1781: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 66 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear O 00/09525

487

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1781: CTCBGTGGCC CCCBBBBGGB TGBGTBBTBC BTGCGCCBCG BTGBTCBT3T CCTTTTTBCT 60 BTGBGG 66

(2) INFORMATION FOR SEQ ID NO: 1782: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 869 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1782: GGGGGTGGCT TCCTGCCGCG TCTCTGGGCC GTCCCGTCCC TCGGCCCCGC GCCGCGCTCG 60

GCTCCTCTCC CTCTGGCCCG GCTCGGGGCG GGGCGGGGCG GTGGGCGGGC GGCGCTGCCC 120

TGCGCGCGGC GCTGGCCCCT GCTGGCCGTC GGCTGCGCGC TGCTGGCTGC CCTGCTGGCC 180

GCGCCGGGGC CTGTCCGCCT CTGCGGGCGC TGTCTCCTGG CTTGTCTTCC GGCTCTTCTG 240

CTGGGGTGGG GCTGGGCGGC CGGCCCGGTG CTGGGGCTCC TCGGGGGGGG GGGCTCTTCC 300

GGGCTGTCTC CCTCCGGGGC GGGGGTTTCT GGCCGTGGGG GTCTTGCCTG GCCTCCGGGC 360

TCCTGCTTGT CTTGCCTTCC TTCTCTGGTC GGTTGTGGCT CGGGGCTCCG TGGGTCCCTG 420

GCGCCCGTTT GTGTTTTGTC TTTTCCCCTG GCGTCCCTGT GCCCCTCTCC TCTCCTTCCT 480

CTGCTTCTCG CTCTCCTTTG TGGGGCCCTC CCTGCTGCTC TTGGTTTTGG GCTTTTTTTC 540

TCTTCCTCCT TTTTCGTGCG TGGGCCTCCG CACGCCTCTT GCCACCTCCT GCGCAGGGCA 600

GCGCCTTGGG GCCAGCGCCG CTCCCGGCGC GGCCAGCAGG GCAGCCAGCA GCGCGCAGCC 660

GACGGCCAGC ATGCTTCCTC CTCGGCTACC ACTCCATGGT CCCGCAGAGG CGGACAGGCG 720

CBCGCCTCTT GCCBCCTCCT GCGCBGGGCB GCGCCTTGGG GCCBGCGCCG CTCCCGGCGC 780

GGCCBGCBGG GCBGCCBGCB GCGCGCBGCC GBCGGCCBGC BTGCTTCCTC CTCGGCTBCC 840

BCTCCBTGGT CCCGCBGBGG CGGBCBGGC 869

(2) INFORMATION FOR SEQ ID NO: 1783: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1783: GCBGCCBGCB GCG 13

(2) INFORMATION FOR SEQ ID NO: 1784: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1784: CGCBGCCGBC GGCC 14

(2) INFORMATION FOR SEQ ID NO: 1785: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 869 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1785:

GGGGGTGGCT TCCTGCCGCG TCTCTGGGCC GTCCCGTCCC TCGGCCCCGC GCCGCGCTCG 60

GCTCCTCTCC CTCTGGCCCG GCTCGGGGCG GGGCGGGGCG GTGGGCGGGC GGCGCTGCCC 120

TGCGCGCGGC GCTGGCCCCT GCTGGCCGTC GGCTGCGCGC TGCTGGCTGC CCTGCTGGCC 180

GCGCCGGGGC CTGTCCGCCT CTGCGGGCGC TGTCTCCTGG CTTGTCTTCC GGCTCTTCTG 240

CTGGGGTGGG GCTGGGCGGC CGGCCCGGTG CTGGGGCTCC TCGGGGGGGG GGGCTCTTCC 300

GGGCTGTCTC CCTCCGGGGC GGGGGTTTCT GGCCGTGGGG GTCTTGCCTG GCCTCCGGGC 360

TCCTGCTTGT CTTGCCTTCC TTCTCTGGTC GGTTGTGGCT CGGGGCTCCG TGGGTCCCTG 420

GCGCCCGTTT GTGTTTTGTC TTTTCCCCTG GCGTCCCTGT GCCCCTCTCC TCTCCTTCCT 480

CTGCTTCTCG CTCTCCTTTG TGGGGCCCTC CCTGCTGCTC TTGGTTTTGG GCTTTTTTTC 540

TCTTCCTCCT TTTTCGTGCG TGGGCCTCCG CACGCCTCTT GCCACCTCCT GCGCAGGGCA 600

GCGCCTTGGG GCCAGCGCCG CTCCCGGCGC GGCCAGCAGG GCAGCCAGCA GCGCGCAGCC 660

GACGGCCAGC ATGCTTCCTC CTCGGCTACC ACTCCATGGT CCCGCAGAGG CGGACAGGCG 720

CBCGCCTCTT GCCBCCTCCT GCGCBGGGCB GCGCCTTGGG GCCBGCGCCG CTCCCGGCGC 780

GGCCBGCBGG GCBGCCBGCB GCGCGCBGCC GBCGGCCBGC BTGCTTCCTC CTCGGCTBCC 840

BCTCCBTGGT CCCGCBGBGG CGGBCBGGC 869

(2) INFORMATION FOR SEQ ID NO: 1786: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1786: O 00/09525

488

GGGGCBGG 8

(2) INFORMATION FOR SEQ ID NO: 1787: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1787: GBBGGCBGCB GGC 13

(2) INFORMATION FOR SEQ ID NO: 1788: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1788: CCBGGBGCBG CCCC 14

(2) INFORMATION FOR SEQ ID NO:1789: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1789: BGGGBGBBGG CBBC 14

(2) INFORMATION FOR SEQ ID NO: 1790: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 128 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1790:

CTCCTGGGGG TBCTGGGGCB GGGBBGGCBG CBGGCBBCBC CBGGBGCBGC CCCBGGGBGB 60

BGGCBBCTGG BCCGBBGGCG CTTGTGGBGB BGGBGTTCBT BGCTGGGCTC CTGGBGGGGB 120

GBTBGBGC 128

(2) INFORMATION FOR SEQ ID NO: 1791: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 244 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1791:

GGGGTGGBBB GGTTTGGBGT BTGTCTTTBT GCBCTGBCBT CTBBGTTCTT TBGCBCTCCT 60

TGGCBBBBCT GCBCCTTCBC BCBGBGCTGC BGBBBTCBGG BBGGCTGCCB BGBGBGCCBC 120

GGCCBGCTTG GBBGTCBTGT TTBCBCBCBG TGBGBTGGTT CCTTCCGGGC TTGTGTGCTC 180

TGCTGTCTCT TGGTTCCTTC CGGTGGTTTC TTCCTGGCTC TTGTCCTTTC TCTTGGCCCT 240

TGGC 244

(2) INFORMATION FOR SEQ ID NO: 1792: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1792: GGBGTBTG 8

(2) INFORMATION FOR SEQ ID NO: 1793: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1793: GCBCTGBCBT CT 12

(2) INFORMATION FOR SEQ ID NO: 1794: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 7 base pairs

(B) TYPE: nucleic acid O 00/09525

489

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1794: CCGGTGG 1

(2) INFORMATION FOR SEQ ID NO: 1795: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1795: GGCCCTTGGC 10

(2) INFORMATION FOR SEQ ID NO:1796: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 87 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1796: GGGGTGGBBB GGTTTGGBGT BTGTCTTTBT GCBCTGBCBT CTBBGTTCTT TBGCBCTCCT 60 TGGCBBBBCT GCBCCTTCBC BCBGBGC 87

(2) INFORMATION FOR SEQ ID NO: 1797: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 489 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1797:

GGGCTCCCGC CGCGBGBGGT TBTGGGCTCC CBGGBCCBCC CGCBCCGCGC GGBCGTTTBC 60

BTTCGCCBCG CBGTGCGCGG CCGBCBTGBC GBBGTTGGGC GCBBTCBGGG TGGCGCCGCB 120

GBBGTGGCCT CCGCGCBGCT GCBGGGBCBC CBTGBBGGGC CBCGCGTGGG GCCGCGCTCG 180

CCGGCCCCCC BCBBTCTCCG BGGCCBGCGC GGTGCCCCCC BGCBGCBBGG CCGGCBGGBC 240

BCBGGCGBGG BGBCBCGCGB GTCGGCGGCC GBGGGTCBTG GTGGGGCTGG GGCTCCGGGG 300

TCTCTGCCCC TCCGTGCTGG TGGGGCTGGG GCTCCGGGGT CTCTGCCCCT CCGTGCCGCG 360

TGGGGCCGCG CTCGCCGGCC CCCCCCTGCC GGGTGGGCTC CCGCCGCGCG CCGGCCTGCC 420

GGCCCCTCGT GGGTCCTGCT GGCCGGGTCC GGGTCCCGGG GGTGGGGCGC GBGTCGGCGG 480

CCGBGGGTC 489

(2) INFORMATION FOR SEQ ID NO: 1798: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1798: GGTGGGGC 8

(2) INFORMATION FOR SEQ ID NO: 1799: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 7 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1799: GGGGCCG η

(2) INFORMATION FOR SEQ ID NO: 1800: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1800: GGCCGGGTCC GGG 1

(2) INFORMATION FOR SEQ ID NO: 1801: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 317 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA EPI-109 490

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1801:

GGGCTCCCGC CGCGBGBGGT TBTGGGCTCC CBGGBCCBCC CGCBCCGCGC GGBCGTTTBC 60

BTTCGCCBCG CBGTGCGCGG CCGBCBTGBC GBBGTTGGGC GCBBTCBGGG TGGCGCCGCB 120

GBBGTGGCCT CCGCGCBGCT GCBGGGBCBC CBTGBBGGGC CBCGCGTGGG GCCGCGCTCG 180

CCGGCCCCCC BCBBTCTCCG BGGCCBGCGC GGTGCCCCCC BGCBGCBBGG CCGGCBGGBC 240

BCBGGCGBGG BGBCBCGCGB GTCGGCGGCC GBGGGTCBTG GTGGGGCTGG GGCTCCGGGG 300

TCTCTGCCCC TCCGTGC 317

(2) INFORMATION FOR SEQ ID NO: 1802: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 308 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1802:

CGGGBGTGGG GGTCCTGGBC GGCBCTGBBG GCBTCCBGGG CTCCCTTCCB GTCCTTCTTG 60

TCCGCTGCCB GCBCCCCTTC BTTCCBGBGG CTGBTGGCCT CCBCCBGGGB CBTGBTTBGG 120

TBGBBBCTBG GBGGCCGGCC TCCBCCBGGG BCBTGGTCCT TCTTGTCCGC TGCCTCTCTG 180

GGGTTTTCGG TCTGGGTGGG CTTTCCTCCT GGGGCTGCTG CTGGGCTCTT CTTTTTGTTT 240

CTGGCCTGGT GCTCTCTCGT GCCCTTTCCC TTGGGTGTCT TGTTTTTGTG GCCTCCBCCB 300

GGGBCBTG 308

(2) INFORMATION FOR SEQ ID NO: 1803: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1803: CGGGBGTGGG GG 12

(2) INFORMATION FOR SEQ ID NO: 1804: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1804: GCCBGCBCCC C 11

(2) INFORMATION FOR SEQ ID NO: 1805: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 7 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1805: CCBCCBG 7

(2) INFORMATION FOR SEQ ID NO: 1806: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 136 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1806:

CGGGBGTGGG GGTCCTGGBC GGCBCTGBBG GCBTCCBGGG CTCCCTTCCB GTCCTTCTTG 60

TCCGCTGCCB GCBCCCCTTC BTTCCBGBGG CTGBTGGCCT CCBCCBGGGB CBTGBTTBGG 120

TBGBBBCTBG GBGGCC 136

(2) INFORMATION FOR SEQ ID NO:1807: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 233 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 1807:

CCCTCCBCBT CTGCTCTGBC CTGCTGGBCT CTGGBTCTGB BGBTBCGCCB TGTBGGGGCG 60

GGBGTGGGGC CTGCTCTCCC GGCCTCCGBT GBTCTCCCCT GCCTCBGCCC CBGTGGGTBG 120

GBGBBBGGCC BGCBGBBGCB GGBGTGGCTG CBTCTTTCCT GGTGGGGCCT GCTCTCCCGG 180

CCTCCGTGTG TTGCTGGGTG TTTTCCCGTC TCTGGTCTGC CTTCGGGGGT CGT 233

(2) INFORMATION FOR SEQ ID NO: 1808: (l) SEQUENCE CHARACTERISTICS: 491

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1808: GBBGBTBCGC C 11

(2) INFORMATION FOR SEQ ID NO: 1809: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1809: CBGCCCCBG 9

(2) INFORMATION FOR SEQ ID NO:1810: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO.-1810: TCCCGTCTCT GG 12

(2) INFORMATION FOR SEQ ID NO: 1811: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 150 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1811:

CCCTCCBCBT CTGCTCTGBC CTGCTGGBCT CTGGBTCTGB BGBTBCGCCB TGTBGGGGCG 60

GGBGTGGGGC CTGCTCTCCC GGCCTCCGBT GBTCTCCCCT GCCTCBGCCC CBGTGGGTBG 120

GBGBBBGGCC BGCBGBBGCB GGBGTGGCTG 150

(2) INFORMATION FOR SEQ ID NO: 1812: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 222 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1812:

CCGGGGCTGC BGCBBCCTCB TCBGCTCTTG CCTGGBGTGG CTCBGCCTGG GCCTGCBGGG 60

CCBCCBGGBG BBTGGCBGCB BGGBTGGCGB GGGTCCTCBT GGCTGGGGTC BCBGBTCCTC 120

TBGCTBGGCB GGGTGBCCBG BGBGGGCGGG TCCTCBTGGC TGGGGGCCTG GGCCTGCBGG 180

GCCGCTCTTG CCTGGBGTGG CTCGCCCBGB GTCTTCCCTG GT 222

(2) INFORMATION FOR SEQ ID NO: 1813: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 7 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1813: CCGGGGC 7

(2) INFORMATION FOR SEQ ID NO: 1814: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1814: GGGCCTGCBG GGCC 14

(2) INFORMATION FOR SEQ ID NO: 1815: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1815: GGCBGCBBGG 10 EPI-109 492

(2) INFORMATION FOR SEQ ID NO: 1816: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 147 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1816:

CCGGGGCTGC BGCBBCCTCB TCBGCTCTTG CCTGGBGTGG CTCBGCCTGG GCCTGCBGGG 60

CCBCCBGGBG BBTGGCBGCB BGGBTGGCGB GGGTCCTCBT GGCTGGGGTC BCBGBTCCTC 120

TBGCTBGGCB GGGTGBCCBG BGBGGGC 147

(2) INFORMATION FOR SEQ ID NO: 1817: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 180 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1817:

CGCTGCBBTC TGCTCCGGGG CTGCBGCBBC CTCBTCBGCT CTTGCCTGGB GTGGCTCBGC 60

CTGGGCCTGC BGGGCCBCCB GGBGBBTGGC BGCBBGGBTG GCGBGGGTCC TCBTGGCTGG 120

GGTCBCCTGG BGGBGGGBGB GCBGGGGGTC CTCBTGGCTG GGGTCCCTCT CTCCCGTCCT 180

(2) INFORMATION FOR SEQ ID NO: 1818: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1818: GGCBGCBBGG 10

(2) INFORMATION FOR SEQ ID NO: 1819: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1819: GGCTGGGG 8

(2) INFORMATION FOR SEQ ID NO: 1820: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1820: GGGGTCBCC 9

(2) INFORMATION FOR SEQ ID NO:1821: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 145 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1821:

CGCTGCBBTC TGCTCCGGGG CTGCBGCBBC CTCBTCBGCT CTTGCCTGGB GTGGCTCBGC 60

CTGGGCCTGC BGGGCCBCCB GGBGBBTGGC BGCBBGGBTG GCGBGGGTCC TCBTGGCTGG 120

GGTCBCCTGG BGGBGGGBGB GCBGG 145

(2) INFORMATION FOR SEQ ID NO: 1822: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 374 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1822:

GTCTTTGTTT CTGGGCTCGT GCCCCBTCCC GGCTTCTCTC TGGTTCCGTC CTCTGTGGTG 60

TTTGGCCCTG CTTCCTTTTG CCTGTTGAGG GGGCAGCAGT TGGGCCCCAA AGGCCCTCTC 120

GTTCACCTTC TGGCACGGAG TTGCATCCCC ATAGTCAAAC TCTGTGGTCG TGTCATAGTC 180

CTCTGTGGTG TTTGGAGTTT CCATCCCGGC TTCTCTCTGG TTCCAAGGGA GBGGGGGCBG 240

CBGTTGGGCC CCBBBGGCCC TCTCGTTCBC CTTCTGGCBC GGBGTTGCBT CCCCBTBGTC 300

BBBCTCTGTG GTCGTGTCBT BGTCCTCTGT GGTGTTTGGB GTTTCCBTCC CGGCTTCTCT 360

CTGGTTCCBB GGGB ₇₄ (2) INFORMATION FOR SEQ ID NO: 1823: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 7 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1823: GGGCCCC 7

(2) INFORMATION FOR SEQ ID NO: 1824: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1824: GGGGGCBGC 9

(2) INFORMATION FOR SEQ ID NO: 1825: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1825: CCCGGCTTC 9

(2) INFORMATION FOR SEQ ID NO:1826: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 303 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1826:

GGGCBCGGGG CBGTGGGCGG GCBBTGTBGG CBBBGCBGCB GGGTGTGGTG TCCGBGGBBT 60

BTGGGGBGGC BGBTGCBGGB GCGCBGBGGG CBGTBGCBBT GBGGBTGBCB GCGBGGCGTG 120

CCGCGGBGBC CTTCBTGGTB CCTGTGGBGB GGCTGTCGGB GGGGGTGTGG TGTCCGCTTG 180

GCGGTTCTTT CGGGTGTTTC TTCTCTGGGT TGGCCTGCTG CTCGTCGTGG TCGCTCCGCT 240

CCCGGGTTCG TCTCGCTCTG TCGCCCCTTC CTTCCTTGTC GTGTTCCTCC CTTCCTTGCC 300

TCT 303

(2) INFORMATION FOR SEQ ID NO:1827: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1827: GGGTTGGC 8

(2) INFORMATION FOR SEQ ID NO: 1828: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1828: CGGGGCBG 8

(2) INFORMATION FOR SEQ ID NO: 1829: d) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1829: CCCGGGTTCG 10

(2) INFORMATION FOR SEQ ID NO: 1830: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1830: GGGTGTGGTG 10

(2) INFORMATION FOR SEQ ID NO: 1831: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 162 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1831:

GGGCBCGGGG CBGTGGGCGG GCBBTGTBGG CBBBGCBGCB GGGTGTGGTG TCCGBGGBBT 60

BTGGGGBGGC BGBTGCBGGB GCGCBGBGGG CBGTBGCBBT GBGGBTGBCB GCGBGGCGTG 120

CCGCGGBGBC CTTCBTGGTB CCTGTGGBGB GGCTGTCGGB GG 162

(2) INFORMATION FOR SEQ ID NO:1832: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 213 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1832:

GCTGCCCGGC GGGGTGTGCG CTTGGCGCTC CCGTGCTCGG TTCTCTGTCT CCCGGTCCCC 60

CTTGCCTGGC GTCTCGGGCC TTCGTCCTCT TCCTCTTCTT CCTTCCGCTC CGTGGGGGCT 120

GCTTGGTGGG GGCCTGTGCC TCGGGGTCCC GGGGCTTCTG GCCCTTGCCG TTCATGGTGG 180

CTAGGTGGGG CGTTCBTGGT GGCTBGGTGG GGC 213

(2) INFORMATION FOR SEQ ID NO:1833: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1833: GGTGGGGC 8

(2) INFORMATION FOR SEQ ID NO: 1834: (I) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1834: GCCCGGCGGG G 11

(2) INFORMATION FOR SEQ ID NO: 1835: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1835: CGGGGCTTCT GGCCC 15

(2) INFORMATION FOR SEQ ID NO: 1836: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 347 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1836:

GGGGTGGGTB GGCCGTGTCT GGGGGTTGGC CBTGTTGGTT GCCTCTTGGT GGTGCGCCGG 60

GCGCGTCTTG GCTTTCTTCT CCTTCGGGCC CTCGGGCCGG TGCTTGTGGG CTCCTCCCGG 120

GCGGCCTCCC CGGGCGGGGG CTTCTTGGCG CTGGCGGGGG GGCCTCCTGC TCTGTGGCTG 180

GGCGTTCCTT GGTGTTCTGG GTGGTGGCGG GCGTGGTGGC CTCTGTGGGG GCCCGCGGCT 240

GCBGGGGTTG CCTGTCTGCT TCGTCCTTTG CGCTCCCGGG CCGCCGGGGT GGGTAGGCCG 300

TGTCTGGGGG TTGGCCATGT TGGTTGCCGG GCCCGCGGCT GCAGGGG 347

(2) INFORMATION FOR SEQ ID NO: 1837: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1837: CCCGGGCGG q EPI-109 495

(2) INFORMATION FOR SEQ ID NO: 1838: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1838: GGCGGGGGGG CC 12

(2) INFORMATION FOR SEQ ID NO: 1839: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1839: CCCGGGCCGC C 11

(2) INFORMATION FOR SEQ ID NO: 1840: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1840: GGCCGTGT 8

(2) INFORMATION FOR SEQ ID NO: 1841: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 664 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1841:

CGGTTTCCTT TGCGGTCTTG GCCCGGGCTC CGGGTGCCCG CCCGCCCGCC GGCCGCCGCC 60

CCGCCGGGCT GTCCCCGCCC CGCCCCGGCC CGGGGCGCGG GGGCGGCCCT CCCGCCCCTC 120

TGGGCCGGCG CGGGCGTCGG CCGCTCGCGC CTGGGGTTCC CTCTCCTCCC CCTGTGCGCC 180

TGCCTCTTGC TCTTCTGCGT CCGCTGCCTT CTCCCCTCTC CTCGGCCGTT GCCTGTGCTG 240

TCCGTCCTGT CGCCCTTCCG TGGTGCTGTT GTCTCTTCTG CCCTCGGTGT GCTGGTGCTG 300

GTGGTGGTGC CTCTGCCCGT GCTCGCCCTG CCTGGGCTGG CCTCTTCGGG TGTGGCTTTG 360

GGGCTCTCTT GGTTGCCCTT TCTTCTCGTG GTGCCTCTCC TCCCTGGCTT GGTCGTTGTC 420

TGGGGTGGTG CTCCTCTCCC TTTCCCTGCT GGCCGTTTGT CCTGTTTTCT GTCTTCCTCT 480

TTCCTCCTGT TTCTCCGTTT GGCTTGCTGC TTGCGGGGCT GTCTCCCTTG CCCCTGTGGG 540

CTTTCCCTGG TCCGGTCTTC TCCTTGGGGG TCGCCCTTCT TGGTGGGCTG GCTCGTCTGT 600

CTTTTTCCTT CCTGGGGGTG GCCGTTGTGG GCGGTGTGGT CCGCCTTGCC TCTGCTGGTC 660

TTTC 664

(2) INFORMATION FOR SEQ ID NO: 1842: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1842: GGCCCGGGC 9

(2) INFORMATION FOR SEQ ID NO:1843: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1843: GCCGGCGCGG GCG 1₃

(2) INFORMATION FOR SEQ ID NO: 1844: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1844: GCCTGGGCTG GCC 1₃

(2) INFORMATION FOR SEQ ID NO: 1845: EPI-109 496

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1845: GGGGGTGGCC G 11

(2) INFORMATION FOR SEQ ID NO: 1846: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1846: GGGGGTGGCC GTTGTGGGCG G 21

(2) INFORMATION FOR SEQ ID NO: 1847: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 266 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1847:

GBTGTTTGTT BCCBBBGCBT CBBGBBTBGC TTTGCTBTCT BBGGBTCBCB TTTBGBCBTB 60

GGBBBBCGCT GTBGGTCBGB BBGBTGTGCT TBCCTTCBCB CBGBGCTGCB GBBBTCBGGB 120

BGGCTGCCBB GBGBGCCBCG GCCBGCTTGG BGTCBTGTTT BCBCBCBGTG BGGTGCTCCG 180

GTGGCTTTTT GCTTGTGTGC TCTGCTGTCT CTGTTCCTTC CGGTGGTTTC TTCCTGGCTC 240

TTGTCCTTTC TCTTGGCCCT TGGCCC 266

(2) INFORMATION FOR SEQ ID NO: 1848: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 7 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1848: GCTCCGG 7

(2) INFORMATION FOR SEQ ID NO: 1849: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1849: CBBGBBTBGC 10

(2) INFORMATION FOR SEQ ID NO: 1850: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1850: CBCBCBGTGB GGTGC 15

(2) INFORMATION FOR SEQ ID NO: 1851: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1851: BCCBBBGCBT CBBGBBTBGC 20

(2) INFORMATION FOR SEQ ID NO: 1852: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1852: GCCBBGBGBG CCBCGGCCBG C 21 O 00/09525

497

(2) INFORMATION FOR SEQ ID NO: 1853: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 196 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1853:

GBTGTTTGTT BCCBBBGCBT CBBGBBTBGC TTTGCTBTCT BBGGBTCBCB TTTBGBCBTB 60

GGBBBBCGCT GTBGGTCBGB BBGBTGTGCT TBCCTTCBCB CBGBGCTGCB GBBBTCBGGB 120

BGGCTGCCBB GBGBGCCBCG GCCBGCTTGG BGTCBTGTTT BCBCBCBGTG BGGTGCTCCG 180

GTGGCTTTTT GCTTGT 196

(2) INFORMATION FOR SEQ ID NO: 1854: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 400 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1854:

ACAGGGGCTG TAATCTTCAT CTGCAGGTGG CATGCCAGTG AAATTTAGAT CATCAAAATC 60

CCACATCTGT GGATCTGTAA TATTTGACAT GTCCTCTTCA GTTTCAGCAA TGGTTTGATC 120

TAACTGAAGC ACCGGCCAGG BCBGGGGCTG TBBTCTTCBT CTGCBGGTGG CBTGCCBGTG 180

BBBTTTBGBT CBTCBBBBTC CCBCBTCTGT GGBTCTGTBB TBTTTGBCBT GTCCTCTTCB 240

GTTTCBGCBB TGGTTTGBTC TBBCTGBBGC BCCGGCCBGG TGGCTCGGTG CTTCTGCCCC 300

TGTTGTTGCG GCGCTCGGTT GGTGTGGCCC CTGTGGTGCT TCGTTTCCCC CTCTTTCTCT 360

TTGTTCGGGG GTTCTTGTGG CGGGCTGCTT GTCTCGTTCC 400

(2) INFORMATION FOR SEQ ID NO: 1855: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 7 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1855: CBGGGGC 7

(2) INFORMATION FOR SEQ ID NO: 1856: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1856: GCBGGTGGC 9

(2) INFORMATION FOR SEQ ID NO: 1857: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1857: GCGGCGCTC 9

(2) INFORMATION FOR SEQ ID NO: 1858: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 140 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1858:

ACAGGGGCTG TAATCTTCAT CTGCAGGTGG CATGCCAGTG AAATTTAGAT CATCAAAATC 60

CCACATCTGT GGATCTGTAA TATTTGACAT GTCCTCTTCA GTTTCAGCAA TGGTTTGATC 120

TAACTGAAGC ACCGGCCAGG 140

(2) INFORMATION FOR SEQ ID NO: 1859: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 140 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1859: BCBGGGGCTG TBBTCTTCBT CTGCBGGTGG CBTGCCBGTG BBBTTTBGBT CBTCBBBBTC 60 CCBCBTCTGT GGBTCTGTBB TBTTTGBCBT GTCCTCTTCB GTTTCBGCBB TGGTTTGBTC 120 EPI-109 498

TBBCTGBBGC BCCGGCCBGG 140

(2) INFORMATION FOR SEQ ID NO: 1860: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 346 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1860:

CTTGBGCBGG BBGCTCTGGG GCBGGGBGCT GGCBGGGCCC BGGGGGGTGG CTTCCTGCBC 60

TGTCCBGBGT GCBCTGTGCC BCBGCBGCBG CTGCBGGGCC BTCBGCTTCB TGGGGCTCTG 120

GGTGGCBGGT CCBGCCBTGG GTCTGGGTGG GGCTGGGCTG CBGGCTCCGG GCGGTCCBGC 180

CBTGGGTCTG GGGGCTGGGC TGCBGGCTCC GGGCGGGCGG GTGCGGGCTG CGTGCTGGGG 240

GCTGCCCCGC AGGCCCTGCG GTCCBGCCBT GGGTCTGGGG GCTGGGCTGC BGGCTCCGGG 300

CGGGCGGGTG CGGGCTGCGT GCTGGGGGCT GCCCCGCAGG CCCTGC 346

(2) INFORMATION FOR SEQ ID NO: 1861: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1861:

GBGCBGGBBG 10

(2) INFORMATION FOR SEQ ID NO:1862: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1862:

GCCBCBGCBG CBGC 14

(2) INFORMATION FOR SEQ ID NO:1863: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1863:

GGGTGCGGGC 10

(2) INFORMATION FOR SEQ ID NO: 1864: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 172 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1864:

CTTGBGCBGG BBGCTCTGGG GCBGGGBGCT GGCBGGGCCC BGGGGGGTGG CTTCCTGCBC 60 TGTCCBGBGT GCBCTGTGCC BCBGCBGCBG CTGCBGGGCC BTCBGCTTCB TGGGGCTCTG 120 GGTGGCBGGT CCBGCCBTGG GTCTGGGTGG GGCTGGGCTG CBGGCTCCGG GC 172

(2) INFORMATION FOR SEQ ID NO: 1865: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 818 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1865:

GCBCCGCCTG GBGCCCTGGG GCCCCCCTGT CTTCTTGGGG BGCGCCTCCT CGGCCBGCTC 60

CBCGTCCCGG BTCBTGCTTT CBGTGCTCBT GGTGTCCTTT CCBGGGGBGB GBGGGGCTGG 120

TCCTCTGCTG TCCTTGCTGG TGCTCBTGGT GTCCTTTCCG CCCTGGGGCC CCCCTGTCTT 180

CTTGGGGCCT CTTCCCTCTG GGGGCCGTCT CTCTCCCTCT CTTGCGTCTC TCTCTTTCTC 240

TCTCTCTCTT CCCCTTTCCC GCTCTTTCTG TCTCGGTGTC TGGTTTTCTC TCTCCGCTGG 300

CTGCCTGTCT GGCCTGCGCT CTTGGCCTGT GCTGTTCCTC CTCCGGTTCC TGTCCTCTCT 360

GTCTGTCGCC CCCTCTGGGG TCTCCCTCTG GGTGGTGGTC TTGTTGCTTG GGCTGGGCTC 420

CGTGTCTCCB GTGCTCBTGG TGTCCGCTGB GGGBGCGTCT GCTGGCGCTG GTCCTCTGCT 480

GTCCTTGCTG GTGCTCBTGG TGTCCTTTCC GCCCTGGGGC CCCCCTGTCT TCTTGGGGCC 540

TCTTCCCTCT GGGGGCCGTC TCTCTCCCTC TCTTGCGTCT CTCTCTTTCT CTCTCTCTCT 600

TCCCCTTTCC CGCTCTTTCT GTCTCGGTGT CTGGTTTTCT CTCTCCGCTG GCTGCCTGTC 660

TGGCCTGCGC TCTTGGCCTG TGCTGTTCCT CCTCCGGTTC CTGTCCTCTC TGTCTGTCGC 720

CCCCTCTGGG GTCTCCCTCT GGCGTGGTGG TCTTGTTGCT TGGGCTGGGC TCCGTGTCTC 780

CBGTGCTCBT GGTGTCCGCT GBGGGBGCGT CTGCTGGC 818 EPI-109 499

(2) INFORMATION FOR SEQ ID NO:1866: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1866: GGGGCCCCCC 10

(2) INFORMATION FOR SEQ ID NO:1867: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1867: GGGGGCCGTC T 11

(2) INFORMATION FOR SEQ ID NO: 1868: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(x ) SEQUENCE DESCRIPTION: SEQ ID NO: 1868: CCBGGGGBGB GBGGGGCTGG 20

(2) INFORMATION FOR SEQ ID NO: 1869: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 364 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1869:

CTCGGTBGBC GCGCTCGBBC TCGGGTGGGC CGGTGGTGBG CGGCGGCGBC BCGCGGBBGG 60

CCCTGCGCGC CGBGBTCBCC TGCBGGGBGB BGTBGGCTTG CBGCBGGBCT CCCBGGBGGG 120

TGBCBGCBGC CBGTBGBGCT BCCTCGTCCT TCBTGGTBCC GTCGGTGTGG TGGCBCGGGC 180

TGTGTGTGBB GGCGBGCTGG GCCCCGTCTG CTGCTCCTCG TGCCGCCTCG TCCTTCATGG 240

TACCGTCGGT GTGGTGGCCT CGGGTGGGCC GGTGGTGGGG CGCGCGCGCT CGCGTGGCTC 300

CGGCTCTTCT TTCCCGGCTC CGTCGGCCCG GGGGCCTTGG TCTCCCTCGT CCTTCBTGGT 360

BCCG ₃64

(2) INFORMATION FOR SEQ ID NO: 1870: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1870: GCBGCBGGBC 10

(2) INFORMATION FOR SEQ ID NO: 1871: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1871: CCCGGCTCCG 10

(2) INFORMATION FOR SEQ ID NO: 1872: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1872: CGGCCCGGGG GCC

(2) INFORMATION FOR SEQ ID NO:1873: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 7 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single EPI-109 500

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1873: CBCGCGG 7

(2) INFORMATION FOR SEQ ID NO: 1874: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 200 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1874:

CTCGGTBGBC GCGCTCGBBC TCGGGTGGGC CGGTGGTGBG CGGCGGCGBC BCGCGGBBGG 60

CCCTGCGCGC CGBGBTCBCC TGCBGGGBGB BGTBGGCTTG CBGCBGGBCT CCCBGGBGGG 120

TGBCBGCBGC CBGTBGBGCT BCCTCGTCCT TCBTGGTBCC GTCGGTGTGG TGGCBCGGGC 180

TGTGTGTGBB GGCGBGCTGG 200

(2) INFORMATION FOR SEQ ID NO: 1875: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 530 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1875:

BCCGGCGGBG CCGCCBGGGT GGBCTGGGBG TGGGTTTCTC CCCGCCGTTC TCBCCCBCCG 60

CGCTGBGCTC BGCGCCTBBG BCTGCTGTTT CTGGBGCTCC TTGGCBBGCC BCBBBCBGCB 120

GBGBGBBBBT CBTGBGCBBB TBBTCCBTTC TGBBBBBBBG GGBTCBBBBB CCTCCCGTTC 180

CCCGTTCGCC TGGCGCGCGC TGCGGGTTCC TCGTGGGTTT CTCCCCGCCG TTCTCCGGTC 240

TGTTGCCTTT GTGGGCTTCT TGTCTTTTTG GCTGTTCTTT TCCTGCTTGG CGTCTTTTCC 300

TTTCTTTGTG CTCGGTTGTG GGTCCGCTGG TCCTTTGCCC TGTGTGTTTC TGCTGCCCGT 360

TCGCCTGGCG CGCGCTGCGG GTTCCTCGTG GGTTTCTCCC CGCCGTTCTC CGGTCTGTTG 420

CCTTTGTGGG CTTCTTGTCT TTTTGGCTGT TCTTTTCCTG CTTGGCGTCT TTTCCTTTCT 480

TTGTGCTCGG TTGTGGGTCC GCTGGTCCTT TGCCCTGTGT GTTTCTGCTG 530

(2) INFORMATION FOR SEQ ID NO: 1876: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1876: CCGGCGGBGC CGCCBGGGTG GBC 23

(2) INFORMATION FOR SEQ ID NO:1877: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1877: CCGCCBGGG 9

(2) INFORMATION FOR SEQ ID NO: 1878: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1878: GGCGCGCGC 9

(2) INFORMATION FOR SEQ ID NO: 1879: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1879: GTGGGTCCGC 10

(2) INFORMATION FOR SEQ ID NO: 1880: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 399 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear 501

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 1880 :

GCCCTGTCGG GCGGGAAGCC TCTCTCCTCT CCCCAGATCC GCGACAGGCC GCAGGCAAGA 60

ACCAGCGCAA CCAGGGCGCG TCCGCACAGA CTTGGAGGCG GCTGCATGCT GCTACCTGCT 120

CCAGAAGCGT CCGGTGGCCG CCGCGCCCTG TCGGGCGGGB BGCCTCTCTC CTCTCCCCBG 180

BTCCGCGBCB GGCCGCBGGC BBGBBCCBGC GCBBCCBGGG CGCGTCCGCB CBGBCTTGGB 240

GGCGGCTGCB TGCTGCTBCC TGCTCGGGCG GGBBGCCTCC GGTGGCCGCC GCGCGTCCGG 300

TGGCCGCCGC GCCTCTCTCC TCTCCCCGTG GCCCTGTCGG GCGGGTCCTG CCGTCCTGTC 360

TCCTTTTCTT TTGCTGTCTT GTCTTCCCGT CTCTGCTTT 399

( 2 ) INFORMATION FOR SEQ ID NO : 1881 : ( l ) SEQUENCE CHARACTERISTICS :

(A) LENGTH : 13 base pairs

(B ) TYPE : nucleic acid

( C ) STRANDEDNESS : single

( D ) TOPOLOGY : linear

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 1881 : CGGGCGGGBB GCC 13

(2 ) INFORMATION FOR SEQ ID NO: 1882 : ( l ) SEQUENCE CHARACTERISTICS :

(A) LENGTH : 8 base pairs

(B ) TYPE : nucleic acid

( C ) STRANDEDNESS : single

( D) TOPOLOGY : linear

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 1882 : CGGGCGGG 8

( 2 ) INFORMATION FOR SEQ ID NO : 1883 : ( l ) SEQUENCE CHARACTERISTICS :

(A) LENGTH : 10 base pairs

(B ) TYPE : nucleic acid

(C) STRANDEDNESS : single

( D ) TOPOLOGY : linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1883: CCGCBCBGBC 10

(2) INFORMATION FOR SEQ ID NO: 1884: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 144 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1884:

GCCCTGTCGG GCGGGAAGCC TCTCTCCTCT CCCCAGATCC GCGACAGGCC GCAGGCAAGA 60

ACCAGCGCAA CCAGGGCGCG TCCGCACAGA CTTGGAGGCG GCTGCATGCT GCTACCTGCT 120

CCAGAAGCGT CCGGTGGCCG CCGC 144

(2) INFORMATION FOR SEQ ID NO: 1885: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 144 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1885:

GCCCTGTCGG GCGGGBBGCC TCTCTCCTCT CCCCBGBTCC GCGBCBGGCC GCBGGCBBGB 60

BCCBGCGCBB CCBGGGCGCG TCCGCBCBGB CTTGGBGGCG GCTGCBTGCT GCTBCCTGCT 120

CCBGBBGCGT CCGGTGGCCG CCGC 144

(2) INFORMATION FOR SEQ ID NO: 1886: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 784 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1886:

GTCTGTCCTC CCCGTCTCCT CCCACTGCTT CTCCCGGGGG CTTCCCCGGC TTCGGGTGGC 60

CGGTGTCCCG GGCTCCGGCG CGGCGGCGGC TTCGGCTGCG GGTGGGTGGC GCGGGCTGCC 120

GGGTCCGCGC GGCGCCTGGG CCCTTGTGCT GCTTTTTGCT TGTTCCGTTC TGGCTGCTCC 180

GGTCTGTGTT GTGGTTGTTT TGTTTCTTCT TGGGTGTGGG CCTTGCGGTT TTGGCTGTGG 240

GCCCTTTGGG GCCTTGGCTT CTGGCTCGTC TGTCCTCCCC GTCTCCTCCC ACTGCTTCTC 300

CCGGGGGCTT CCCCGGCTTC GGGTGGCCGG TGTCCCGGGC TCCGGCGCGG CGGCGGCTTC 360

GGCTGCGGGT GGGTGGCGCG GGCTGCCGGG TCCGCGCGGC GCCTGGGCCC TTGTGCTGCT 420

TTTTGCTTGT TCCGTTCTGG CTGCTCCGGT CTGTGTTGTG GTTGTTTTGT TTCTTCTTGG 480

GTGTGGGCCT TGCGGTTTTG GCTGTGGGCC CTTTGGGGCC TTGGCTTCTG GCTCCATCCA 540

CATGATTGCT TAGATTTGTG CTGTATCTCT CAGGATTATC ACTGATTACA CATCCAACCA 600 00/09525

502

GTGCCAGCCA AAAGGATGCC CTGAGGCAAA GGGTTTCCAT CTTGAGGCAA ATTTGAGGAC 660

BTCCBCBTGB TTGCTTBGBT TTGTGCTGTB TCTCTCBGGB TTBTCBCTGB TTBCBCBTCC 720

BBCCBGTGCC BGCCBBBBGG BTGCCCTGBG GCBBBGGGTT TCCBTCTTGB GGCBBBTTTG 780

BGGB 784

(2) INFORMATION FOR SEQ ID NO: 1887: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1887: GBGGCBBBGG G 11

(2) INFORMATION FOR SEQ ID NO: 1888: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1888: GCCBGCCBBB BGGB 14

(2) INFORMATION FOR SEQ ID NO: 1889: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1889: CGCCTGGGCC C 11

(2) INFORMATION FOR SEQ ID NO: 1890: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 349 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1890:

CTGCTGBGGC TTGGGTCTCC GGGCGBTTCT CTGCBGBBGB TGCTCBBBGG GCTCCGGCBG 60

TTCCTCCTTG BTCTGGTCGC TGTCGTBCCB GTCGGBCCBG TBBTTCBGBT CBTCBTTGGC 120

TCCTBTTTCT TCTGCBBBCB GCTGBGTGGB GBCBBGBBBB BBGBCTGCCB BGGCCBCGBG 180

GBTTTTCBTG TTGGBTTTTG CGBCGGBCBG TCCCGCGGGG TGCTGAGTTT CTCTGGTTCC 240

TCCGBGCGCB CGTGGTCGCT CCGCGTTTCT CTGGTTCCTC CGGTCCCGCG GGGTGCTGTC 300

TGGTCGCTGT CGTGGCTTGG GTCTCCGGGC GGTTTCCTTC CTTTTCCGC 349

(2) INFORMATION FOR SEQ ID NO: 1891: d) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1891: CTCCGGGCGB 10

(2) INFORMATION FOR SEQ ID NO: 1892: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1892: GGCCBCGBGG 10

(2) INFORMATION FOR SEQ ID NO: 1893: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1893: GGGTCTCCGG GCG 1₃

(2) INFORMATION FOR SEQ ID NO: 1894: (l) SEQUENCE CHARACTERISTICS: EPI-109 503

(A) LENGTH . 14 base pairs

(B ) TYPE : nucleic acid

( C) STRANDEDNESS : single

( D) TOPOLOGY : linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1894: GGGTCTCCGG GCGG 14

(2) INFORMATION FOR SEQ ID NO: 1895: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 250 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1895:

CTGCTGBGGC TTGGGTCTCC GGGCGBTTCT CTGCBGBBGB TGCTCBBBGG GCTCCGGCBG 60

TTCCTCCTTG BTCTGGTCGC TGTCGTBCCB GTCGGBCCBG TBBTTCBGBT CBTCBTTGGC 120

TCCTBTTTCT TCTGCBBBCB GCTGBGTGGB GBCBBGBBBB BBGBCTGCCB BGGCCBCGBG 180

GBTTTTCBTG TTGGBTTTTG CGBCGGBCBG TCCCGCGGGG TGCTGAGTTT CTCTGGTTCC 240

TCCGBGCGCB 250

(2) INFORMATION FOR SEQ ID NO: 1896: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 662 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1896:

GGGCTBBGBT GBTCCBCBTC BCTBCCBCGT TGCCCBCCBC BGBGGTCBCC BCBBTGBCCG 60

TGTBGGCBGC TGCCCBBBGG BCBBTTTGCC BGGCTGGTTG CBCGBBCTGB TTGGGTTCCG 120

BGGTGTTBGT GGBGBTGTTT GGGGBGBGGT CTGBGTCCBC CGGGBGGBCG TTBTCCBTTT 180

CGBBGCTBGG CGGTBBBGCC CTBCTBTCTG TBCBCBBCCC CCCTCTGCBG CBGBGTCCTG 240

TCGTGGCGCC TGGGGCTCBG GGTCCGGGCT AAGATGATCC ACATCACTAC CACGTTGCCC 300

ACCACAGAGG TCACCACAAT GACCGTGTAG GCAGCTGCCC AAAGGACAAT TTGCCAGGCT 360

GGTTGCACGA ACTGATTGGG TTCCGAGGTG TTAGTGGAGA TGTTTGGGGA GAGGTCTGAG 420

TCCACCGGGA GGACGTTATC CATTTCGAAG CTAGGCGGTA AAGCCCTACT ATCTGTACAC 480

AACCCCCCTC TGCAGCAGAG TCCTGTCGTG GCGCCTGGGG CTCAGGGTCC GTCCTGTCGT 540

GGCGCCTGGG GCTCTTCTTT TGTGGGCTCT TTGGTGGCTG TGGCTGTGGT CTCTGTGGTT 600

GCTGCCCTGG GTCTGGGGGT GTGGCCTTGG GGCCGTCCTC TGGCTCCTCC TCGTGGGCCC 660

CC 662

(2) INFORMATION FOR SEQ ID NO: 1897: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1897: GGGBGGBCG 9

(2) INFORMATION FOR SEQ ID NO: 1898: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 7 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1898: GGGTCCG η

(2) INFORMATION FOR SEQ ID NO:1899: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1899: GGGCCCCC 8

(2) INFORMATION FOR SEQ ID NO: 1900: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 567 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1900: GGBGCTGBTB CTGCBGATTT CBGBGGGBBG BBCCCTGBTB CTCBCCBGCT TCBGCTCTGG 60 O 00/09525

504

BGCBCBBGBG BBBGBGCBGC BGGGGGBGBG GBBGBBGCBG CBTCTTCCCB GBGBGGCTGC 120

CTGBGCBBBT GCTGGTTTTC CTTTCCBGTC TTGGGTTTTB TBBCTCCCBG BBGGCBBGBG 180

BGGGGCBBGG CGTTTTCTTC TCTCGCTGGT TTTCCTTTCC TGGCAGTGGG TGGGGGTGGG 240

GGTGGGGTGG CTTCCTTGTT CCTGGGGGTG TCCTCTTGCT CTGGGCTTTT CTCCCCTTTT 300

CCTTCCTGTC TGTTTTCCTG GGGCTCTCCT CTGTCTCTGT GTCCTTGCCC TGGCCCTCTT 360

CCCTCTCCTG TCTCCTGTCC CTGTGTTCCG CCCGTCTTCC CTCTCCTGAC CTCCTTTTCC 420

TCCGCTGGGT GGGGCCCTGC CTGTTCTCTG CTCCCTGGCT TGGGGTTTCT TCTGTGTGTC 480

TTCTTCCTCT GTTGGCTGGC TTTCTCCTTC TTTTGTCTTC CTGGGTGCCC CTTCTTCCTT 540

TCTTGGGTCC TTGGTGCTTG GGCTGGG 567

(2) INFORMATION FOR SEQ ID NO:1901: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1901: GGBGCBCBBG 10

(2) INFORMATION FOR SEQ ID NO: 1902: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1902: GBBGCBGC

(2) INFORMATION FOR SEQ ID NO: 1903: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1903: GGGGCBBGGC G 11

(2) INFORMATION FOR SEQ ID NO: 1904: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 190 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1904: GGBGCTGBTB CTGCBGATTT CBGBGGGBBG BBCCCTGBTB CTCBCCBGCT TCBGCTCTGG 60 BGCBCBBGBG BBBGBGCBGC BGGGGGBGBG GBBGBBGCBG CBTCTTCCCB GBGBGGCTGC 120 CTGBGCBBBT GCTGGTTTTC CTTTCCBGTC TTGGGTTTTB TBBCTCCCBG BBGGCBBGBG 180 BGGGGCBBGG 190

(2) INFORMATION FOR SEQ ID NO: 1905 (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2028 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1905: GCGTCTTGGG GTGCBGGGCC CBTCCTGCTG CGCCTGGGCG CTGCTGTGCG TCCGTCTGCT 60 GGGGGGCCGG GGTGGCTGGG CCCTGCTTGC CGCACGACCC CGGGCCGACC CGAGGCTCGG 120 GGGGCTGTGT TCTGGCGCTG GTGGGCTTGG GCCCCTCTGG GGGCTGGGTT TCCTGCTGCG 180 CCTGGGCGCT GGCGTCTTGG GGTGCGGGGC CGGGGGGCCG GGGGGCCGCT GTTCGTGGGC 240 CTGGGGGTGC CTGTGGCTGC CGGTTGCCCC GGTTGGTGGC GCCGTCCTGC TGCCGGTCGT 300 TGGCTGGGTC CCCCCGCCCG TTTCCTGGGG TCCGCGTGGG GTGCTCCGGT TCCTCGTGCC 360 GCTGCTGCCT TGTCTTTCCG GCCGTGGCGG CGTGGTGGTC CGCCCCCCCT GGCCTTCTGC 420 TCGGGGTCTG GCTGGTTGCC GGTGCCCTTG GCGGCGGTCT TCTTCCTGGT GGCTCTGGGC 480 CCGGCCGGTC TCGGGCGTCT CGTGTTCGCT CTTGTGCTGT TCCGGCCGCT CCTTCCTCTT 540 CCGCCGCCGC CGCTCCCCGC CCGCTCGTCG CCCTGGCCCG GCCTCCTCCT GGCCGCTGTC 600 TCGGGCGGCG GCCTTGGCGC TCCGTTTGGG GCTGCCTCTG GCGCTTCCGG CCCTCGGCCT 660 GGGCGCTCTC TTCCGCCTGT GCTGGTGGCC CTCGTGGGCC CCTCCTGGCC TCCGGTGTCC 720 TGTGGTCCCC CGGCTGGTGG CCGGGCCGGT TGGGCGGGCG TGGGCGCCGG CGGGTCCTCC 780 GGGCTGCCCT TCTCCGCCGG GGGTCCCGCG CTCCTGCTGT TCCCTGGGCT CTTCTGCCTC 840 TCTCCTGGGT GGGTGCTGGG TGCCGGGGTC TCCGGGCTTG CCCCGCGCTG CTGGGCGTTC 900 TGCGGTCTTG GGGTTGTCTG TGGCCCCGCT CGTGTCGCCC TCCGTCGCCC GTCGCCGGCC 960 TCGTCCCCTC CTGGGTGCGC GGCGGGCTGG TCCTGGCGTT TTGCTCCTTC CTGGGCGTCT 1020 TGGGGTGCBG GGCCCBTCCT GCTGCGCCTG GGCGCTGCTG TGCGTCCGTC TGCTGGGGGG 1080 CCGGGGTGGC TGGGCCCTGC TTGCCGCACG ACCCCGGGCC GACCCGAGGC TCGGGGGGCT 1140 505

GTGTTCTGGC GCTGGTGGGC TTGGGCCCCT CTGGGGGCTG GGTTTCCTGC TC--ι~-,ι_CTGGG 1200

CGCTGGCGTC TTGGGGTGCG GGGCCGGGGG GCCGGGGGGC CGCTGTTCGT GGGCCTGGGG 1260

GTGCCTGTGG CTGCCGGTTG CCCCGGTTGG TGGCGCCGTC CTGCTGCCGG TCGTTGGCTG 1320

GGTCCCCCCG CCCGTTTCCT GGGGTCCGCG TGGGGTGCTC CGGTTCCTCG TGCCGCTGCT 1380

GCCTTGTCTT TCCGGCCGTG GCGGCGTGGT GGTCCGCCCC CCCTGGCCTT CTGCTCGGGG 1440

TCTGGCTGGT TGCCGGTGCC CTTGGCGGCG GTCTTCTTCC TGGTGGCTCT GGGCCCGGCC 1500

GGTCTCGGGC GTCTCGTGTT CGCTCTTGTG CTGTTCCGGC CGCTCCTTCC TCTTCCGCCG 1560

CCGCCGCTCC CCGCCCGCTC GTCGCCCTGG CCCGGCCTCC TCCTGGCCGC TGTCTCGGGC 1620

GGCGGCCTTG GCGCTCCGTT TGGGGCTGCC TCTGGCGCTT CCGGCCCTCG GCCTGGGCGC 1680

TCTCTTCCGC CTGTGCTGGT GGCCCTCGTG GGCCCCTCCT GGCCTCCGGT GTCCTGTGGT 1740

CCCCCGGCTG GTGGCCGGGC CGGTTGGGCG GGCGTGGGCG CCGGCGGGTC CTCCGGGCTG 1800

CCCTTCTCCG CCGGGGGTCC CGCGCTCCTG CTGTTCCCTG GGCTCTTCTG CCTCTCTCCT 1860

GGGTGGGTGC TGGGTGCCGG GGTCTCCGGG CTTGCCCCGC GCTGCTGGGC GTTCTGCGGT 1920

CTTGGGGTTG TCTGTGGCCC CGCTCGTGTC GCCCTCCGTC GCCCGTCGCC GGCCTCGTCC 1980

CCTCCTGGGT GCGCGGCGGG CTGGTCCTGG CGTTTTGCTC CTTCCTGG 2028

( 2 ) INFORMATION FOR SEQ ID NO : 1906 : ( l ) SEQUENCE CHARACTERISTICS :

(A) LENGTH : 9 base pairs

(B) TYPE : nucleic acid

( C) STRANDEDNESS : single

(D) TOPOLOGY : linear

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 1906 : GCGGGGCCG 9

( 2 ) INFORMATION FOR SEQ ID NO: 1907 : ( l ) SEQUENCE CHARACTERISTICS :

(A) LENGTH : 8 base pairs

(B ) TYPE : nucleic acid

( C ) STRANDEDNESS : single

( D ) TOPOLOGY : linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 1907: CGGGGGGC 8

(2) INFORMATION FOR SEQ ID NO: 1908: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1908: GCGCGGCGGG C 11

(2) INFORMATION FOR SEQ ID NO:1909: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 43 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO: 1909 : GCGTCTTGGG GTGCBGGGCC CBTCCTGCTG CGCCTGGGCG CTG 43

( 2 ) INFORMATION FOR SEQ ID NO : 1910 : (l ) SEQUENCE CHARACTERISTICS :

(A) LENGTH : 535 base pairs

(B) TYPE : nucleic acid

( C ) STRANDEDNESS : single

( D) TOPOLOGY : linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1910:

CTGCCCCBGT TTTTGBTCCT CBCBTGCCGT GGGGBGGBCB BTGGCTGCCT CCCCGGGGTT 60

TCTGCTGCTT GCTGCTTCTT TCCCGTCTCC CTTCTTTCCC GTCTCCTTTT TGCCTCTTTG 120

GGTTCCTGTT GTTTCTGGCC TGCTTGGTGG CGGCTTGTGC GTTTCCTCTC TCTTCTCTTG 180

GGTCTCCGCT TCTCGTCCTG CCTTTTCCTG TCTCTGTCGC GCCGTTCCTC CTCCGGCGTC 240

CTCCTGCCCT GTGCTGTTTG CCTCGGGTGG TGCGGGTCCC GGTGCTCCCC CGGCGGGCCC 300

GCTGGTTGCC TGGGCCTGTC TGGTGGGGTG TGGGGCCGCT GGGTTGGGGG TGTGGTGGGC 360

TCTTCTGTGG CCTGTGGGGC TGTTGGTGTC TCTGTGGGCG TGTGCTGGGT CTTGGGGCTT 420

CCTCCCTTGT GCTGGGTGCG GCCTCCCCGC CCCCCTTCTG GGCCGGTGGC CTGGCTCCTT 480

GTGGGCGCTT CTGGCTCTTG CCCTGTCCTT CTTCGCCTCG TGGCTGCTGG GCTGC 535

(2) INFORMATION FOR SEQ ID NO: 1911: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1911: CCCCGGGG 8

(2) INFORMATION FOR SEQ ID NO: 1912: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1912: GGGGCCGCTG GG 12

(2) INFORMATION FOR SEQ ID NO: 1913: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1913: GGGGGTGTGG 10

(2) INFORMATION FOR SEQ ID NO: 1914: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 44 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1914: CTGCCCCBGT TTTTGBTCCT CBCBTGCCGT GGGGBGGBCB BTGG 44

(2) INFORMATION FOR SEQ ID NO: 1915: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 756 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1915:

CGGCCCTTCT CACTGGAGGC ACCGGGCAGT CCTCCATGGG AGGGTTGGGC TTGGCCGGGG 60

CTGCCCGGTG CCTCCTCTTG GCTGGTCCCT CGTTGTCCTT GGGCCCCGCT CCCGCTGCTC 120

GGCCTCCGTG TTCTTTGGCC TCTTGCTCCG CCTGCTGTCT TGTCCCGTCC CCTCCTCGCT 180

TGCGTTTCCC TCTTCCTTGT CTTCCAGGCC TTCCTCCGCT TCCGCTGCTG GGGCCCGCGC 240

CGGGGGGGCG CTCGGCTCCG CGGCTTCCTC CCCGGCTGGG GGGTCCTGGT CTCCGGGGCC 300

TGCGGCTCGC GGGCTCGGGG CTGCGTGCGC CGCGCGCGGC GTCCGCGGTG GGTGGCGCTG 360

TCCCGCCGTG GTGTGTCTCC GTTCTCGTCC TGCGCCGTCC TGGTCTGCCC GTGGGGTCCT 420

GGGCGTGGTG GGGGGCGTCT GGTGCCTCGT CTGCCCCGTG GGGCTTCGGG CTCGGGGCTG 480

TTCGTCCCCC CTGCCGCTCT GTGGCCTCCG GGGCTCCTCG TTTTCGCTGC TTCGGGTGTC 540

CTTCTCGGCG TGTGGCCCCG GGTCCCGGCC CTGCTGGGCT GGGCGGGGTC GCTGCCCTGG 600

GCTTCTGGCC CGTCTGGTTG TCTGTCGGTG CTTGTCTCGG GTTTCTGGCC TCTGTGCTGG 660

GCGCTTCTCT GCCTCCTGCT CCGCCCTCCT GGTGGCTCGG CTGGGGGTGC CCGTGCGGGG 720

GTGGGTGTGG GGTGTTTTCG GGGTCCTCCC CTTCCC 756

(2) INFORMATION FOR SEQ ID NO: 1916: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1916: GGGCGGGGTC GC 12

(2) INFORMATION FOR SEQ ID NO: 1917: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1917: GCGCCGTCC 9

(2) INFORMATION FOR SEQ ID NO: 1918: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear O /0

507

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1918: GGGCGTGGTG G 11

(2) INFORMATION FOR SEQ ID NO: 1919: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 43 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1919: CGGCCCTTCT CACTGGAGGC ACCGGGCAGT CCTCCATGGG AGG 43

(2) INFORMATION FOR SEQ ID NO: 1920: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 302 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1920:

GTTTCATCTT GGCTTTATCC TCTCCCCTTG TTCCTCCCCT CTCCTGCTCT GGRGTCTCCT 60

CTTCCCTCCC TCCCCTGCCG TGTTGTCTGT GGGTGTCGTT TCGCTCTTGT TGCCCTGGGC 120

CCTTCCCTGC TGGGGGGGAG TTTCATCTTG GGTTTCBTCT TGGCTTTBTC CTCTCCCCTT 180

GTTCCTCCCC TCTCCTGCTC TGGRGTCTCC TCTTCCCTCC CTCCCCTGCC GTGTTGTCTG 240

TGGGTGTCGT TTCGCTCTTG TTGCCCTGGG CCCTTCCCTG CTGGGGGGGB GTTTCBTCTT 300 GG 302

(2) INFORMATION FOR SEQ ID NO: 1921: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1921: GGGGGAGTT 9

(2) INFORMATION FOR SEQ ID NO: 1922: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1922: GCCCTGGGCC C 11

(2) INFORMATION FOR SEQ ID NO: 1923: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 151 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1923:

GTTTCATCTT GGCTTTATCC TCTCCCCTTG TTCCTCCCCT CTCCTGCTCT GGRGTCTCCT 60

CTTCCCTCCC TCCCCTGCCG TGTTGTCTGT GGGTGTCGTT TCGCTCTTGT TGCCCTGGGC 120

CCTTCCCTGC TGGGGGGGAG TTTCATCTTG G 151

(2) INFORMATION FOR SEQ ID NO: 1924: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 151 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1924:

GTTTCBTCTT GGCTTTBTCC TCTCCCCTTG TTCCTCCCCT CTCCTGCTCT GGRGTCTCCT 60

CTTCCCTCCC TCCCCTGCCG TGTTGTCTGT GGGTGTCGTT TCGCTCTTGT TGCCCTGGGC 120

CCTTCCCTGC TGGGGGGGBG TTTCBTCTTG G 151

(2) INFORMATION FOR SEQ ID NO: 1925: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 7 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1925: GGGGGBG η O 00/09525

508

(2) INFORMATION FOR SEQ ID NO: 1926: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 1926: GTGGGTGTCC 10

(2) INFORMATION FOR SEQ ID NO: 1927: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 91 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1927: CCGTGTTGTC BGTGGTGCTG CCCGTTTGBG GTBTGGCGCT CCBCCBBTTC CCTTTTCTCC 60 TTGTTTTCCG TTTCTCTTGC CGTCTGTGGT T 91

(2) INFORMATION FOR SEQ ID NO: 1928: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 1928: CCCGTTTGBG GTBTGGC 1₇

(2) INFORMATION FOR SEQ ID NO: 1929: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO.-1929: GCTCCBCCBB TTCCCTTTTC TCC 23

(2) INFORMATION FOR SEQ ID NO: 1930: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1930: TTGTTTTCCG TTTCTCTTG 19

(2) INFORMATION FOR SEQ ID NO: 1931: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1931: CCGTCTGTGG TT 12

(2) INFORMATION FOR SEQ ID NO: 1932: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH. 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS. single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1932: CCCGTTTGAG GTATGGC 1

(2) INFORMATION FOR SEQ ID NO: 1933: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1933: GCTCCBCCAA TTCCCTTTTC TCC 23

(2) INFORMATION FOR SEQ ID NO: 1934: (l) SEQUENCE CHARACTERISTICS: 509

(A) LENGTH: 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1934: GGGCCCBGCC CCGCCGCCTT TTCTBGCCCC GGCC 34

(2) INFORMATION FOR SEQ ID NO: 1935: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1935: GGGCCCBGCC CCGCCGCCTT TTCTBGCCCC GGC 33

(2) INFORMATION FOR SEQ ID NO: 1936: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1936: GGGCCCBGCC CCGCCGCCTT TTCTBGCCCC GG 32

(2) INFORMATION FOR SEQ ID NO: 1937: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1937: GGGCCCBGCC CCGCCGCCTT TTCTBGCCCC G 31

(2) INFORMATION FOR SEQ ID NO: 1938: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1938: GGGCCCBGCC CCGCCGCCTT TTCTBGCCCC 30

(2) INFORMATION FOR SEQ ID NO: 1939: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1939: GGGCCCBGCC CCGCCGCCTT TTCTBGCCC 29

(2) INFORMATION FOR SEQ ID NO: 1940: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i ) SEQUENCE DESCRIPTION : SEQ ID NO : 1940 : GGGCCCBGCC CCGCCGCCTT TTCTBGCC 28

( 2 ) INFORMATION FOR SEQ ID NO : 1941 : ( l ) SEQUENCE CHARACTERISTICS :

(A) LENGTH : 27 base pairs

(B ) TYPE : nucleic acid

(C ) STRANDEDNESS : single

( D ) TOPOLOGY : linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO:1941: GGGCCCBGCC CCGCCGCCTT TTCTBGC 27

(2) INFORMATION FOR SEQ ID NO: 1942: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single ππ-iυy 510

(D) TOPOLOGY, linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1942: GGGCCCBGCC CCGCCGCCTT TTCTBG 26

(2) INFORMATION FOR SEQ ID NO: 1943: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1943: GGGCCCBGCC CCGCCGCCTT TTCTB 25

(2) INFORMATION FOR SEQ ID NO: 1944: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1944: GGGCCCBGCC CCGCCGCCTT TTCT 24

(2) INFORMATION FOR SEQ ID NO: 1945: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1945: GGGCCCBGCC CCGCCGCCTT TTC 23

(2) INFORMATION FOR SEQ ID NO: 1946: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1946: GGGCCCBGCC CCGCCGCCTT TT 22

(2) INFORMATION FOR SEQ ID NO: 1947: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1947: GGGCCCBGCC CCGCCGCCTT T 21

(2) INFORMATION FOR SEQ ID NO:1948: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1948: GGGCCCBGCC CCGCCGCCTT 20

(2) INFORMATION FOR SEQ ID NO: 1949: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1949: GGGCCCBGCC CCGCCGCCT 19

(2) INFORMATION FOR SEQ ID NO: 1950: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1950: GGGCCCBGCC CCGCCGCC 18 (2) INFORMATION FOR SEQ ID NO: 1951: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1951: GGGCCCBGCC CCGCCGC 1₇

(2) INFORMATION FOR SEQ ID NO: 1952: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1952: GGGCCCBGCC CCGCCG 16

(2) INFORMATION FOR SEQ ID NO: 1953: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1953: GGGCCCBGCC CCGCC 15

(2) INFORMATION FOR SEQ ID NO: 1954: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1954: GGGCCCBGCC CCGC 14

(2) INFORMATION FOR SEQ ID NO: 1955: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1955: GGGCCCBGCC CCG 13

(2) INFORMATION FOR SEQ ID NO: 1956: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1956: GGGCCCBGCC CC 12

(2) INFORMATION FOR SEQ ID NO: 1957: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1957: GGGCCCBGCC C 11

(2) INFORMATION FOR SEQ ID NO: 1958: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1958: GGCCCBGCCC CGCCGCCTTT TCTBGCCCCG GC 32

(2) INFORMATION FOR SEQ ID NO: 1959: (l) SEQUENCE CHARACTERISTICS: O 00/09525

512

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1959: GCCCBGCCCC GCCGCCTTTT CTBGCCCCGG C 31

(2) INFORMATION FOR SEQ ID NO: 1960: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO.-1960: CCCBGCCCCG CCGCCTTTTC TBGCCCCGGC 30

(2) INFORMATION FOR SEQ ID NO: 1961: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1961: CCBGCCCCGC CGCCTTTTCT BGCCCCGGC 29

(2) INFORMATION FOR SEQ ID NO: 1962: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1962: CBGCCCCGCC GCCTTTTCTB GCCCCGGC 28

(2) INFORMATION FOR SEQ ID NO: 1963: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1963: BGCCCCGCCG CCTTTTCTBG CCCCGGC 27

(2) INFORMATION FOR SEQ ID NO: 1964: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1964: GCCCCGCCGC CTTTTCTBGC CCCGGC 26

(2) INFORMATION FOR SEQ ID NO: 1965: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1965: CCCCGCCGCC TTTTCTBGCC CCGGC 25

(2) INFORMATION FOR SEQ ID NO: 1966: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1966: CCCGCCGCCT TTTCTBGCCC CGGC 24

(2) INFORMATION FOR SEQ ID NO: 1967: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1967: CCGCCGCCTT TTCTBGCCCC GGC 23

(2) INFORMATION FOR SEQ ID NO:1968: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1968: CGCCGCCTTT TCTBGCCCCG GC 22

(2) INFORMATION FOR SEQ ID NO: 1969: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1969: GCCGCCTTTT CTBGCCCCGG C 21

(2) INFORMATION FOR SEQ ID NO: 1970: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1970: CCGCCTTTTC TBGCCCCGGC 20

(2) INFORMATION FOR SEQ ID NO: 1971: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1971: CGCCTTTTCT BGCCCCGGC 19

(2) INFORMATION FOR SEQ ID NO: 1972: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1972: GCCTTTTCTB GCCCCGGC 18

(2) INFORMATION FOR SEQ ID NO: 1973: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1973: CCTTTTCTBG CCCCGGC 1

(2) INFORMATION FOR SEQ ID NO: 1974: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1974: CTTTTCTBGC CCCGGC 16

(2) INFORMATION FOR SEQ ID NO:1975: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1975: TTTTCTBGCC CCGGC 15 (2) INFORMATION FOR SEQ ID NO: 1976: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1976: TTTCTBGCCC CGGC 14

(2) INFORMATION FOR SEQ ID NO:1977: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1977: TTCTBGCCCC GGC 13

(2) INFORMATION FOR SEQ ID NO: 1978: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1978: TCTBGCCCCG GC 12

(2) INFORMATION FOR SEQ ID NO: 1979: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1979: CTBGCCCCGG C 11

(2) INFORMATION FOR SEQ ID NO: 1980: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1980: GCGBGGCTGT CBCCTCGCTG GGCCC 25

(2) INFORMATION FOR SEQ ID NO: 1981: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1981: GCGBGGCTGT CBCCTCGCTG GGCC 24

(2) INFORMATION FOR SEQ ID NO: 1982: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1982: GCGBGGCTGT CBCCTCGCTG GGC 23

(2) INFORMATION FOR SEQ ID NO: 1983: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1983: GCGBGGCTGT CBCCTCGCTG GG 22

(2) INFORMATION FOR SEQ ID NO: 1984: (i) SEQUENCE CHARACTERISTICS. tri-iuy 515

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1984: GCGBGGCTGT CBCCTCGCTG G 21

(2) INFORMATION FOR SEQ ID NO: 1985: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1985: GCGBGGCTGT CBCCTCGCTG 20

(2) INFORMATION FOR SEQ ID NO: 1986: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1986: GCGBGGCTGT CBCCTCGCT 19

(2) INFORMATION FOR SEQ ID NO: 1987: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1987: GCGBGGCTGT CBCCTCGC 18

(2) INFORMATION FOR SEQ ID NO: 1988: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1988: GCGBGGCTGT CBCCTCG 17

(2) INFORMATION FOR SEQ ID NO: 1989: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1989: GCGBGGCTGT CBCCTC 16

(2) INFORMATION FOR SEQ ID NO: 1990: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1990: GCGBGGCTGT CBCCT 15

(2) INFORMATION FOR SEQ ID NO: 1991: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1991: GCGBGGCTGT CBCC 14

(2) INFORMATION FOR SEQ ID NO: 1992: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1992. GCGBGGCTGT CBC 13

(2) INFORMATION FOR SEQ ID NO: 1993: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1993: GCGBGGCTGT CB 12

(2) INFORMATION FOR SEQ ID NO: 1994: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1994: GCGBGGCTGT C 11

(2) INFORMATION FOR SEQ ID NO: 1995: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 1995: GCGBGGCTGT 10

(2) INFORMATION FOR SEQ ID NO: 1996: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1996: CGBGGCTGTC BCCTCGCTGG GCCC 24

(2) INFORMATION FOR SEQ ID NO:1997: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1997: GBGGCTGTCB CCTCGCTGGG CCC 23

(2) INFORMATION FOR SEQ ID NO: 1998: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1998: BGGCTGTCBC CTCGCTGGGC CC 22

(2) INFORMATION FOR SEQ ID NO: 1999: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1999: GGCTGTCBCC TCGCTGGGCC C 21

(2) INFORMATION FOR SEQ ID NO:2000: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS. single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2000: GCTGTCBCCT CGCTGGGCCC 20 O 00/09525

EPI-109 517

(2) INFORMATION FOR SEQ ID NO: 2001: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 2001: CTGTCBCCTC GCTGGGCCC 19

(2) INFORMATION FOR SEQ ID NO: 2002: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2002: TGTCBCCTCG CTGGGCCC 18

(2) INFORMATION FOR SEQ ID NO: 2003: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2003: GTCBCCTCGC TGGGCCC 17

(2) INFORMATION FOR SEQ ID NO: 2004: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2004: TCBCCTCGCT GGGCCC 16

(2) INFORMATION FOR SEQ ID NO:2005: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2005: CBCCTCGCTG GGCCC 15

(2) INFORMATION FOR SEQ ID NO: 2006: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: Single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2006: BCCTCGCTGG GCCC 14

(2) INFORMATION FOR SEQ ID NO:2007: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2007: CCTCGCTGGG CCC 1₃

(2) INFORMATION FOR SEQ ID NO:2008: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2008: CTCGCTGGGC CC 12

(2) INFORMATION FOR SEQ ID NO: 2009: (l) SEQUENCE CHARACTERISTICS: O 00/09525

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 2009: TCGCTGGGCC C 11

(2) INFORMATION FOR SEQ ID NO:2010: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2010: CGCTGGGCCC 10

(2) INFORMATION FOR SEQ ID NO:2011: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2011: GCGCGGCCGT CBTGGCGGCG TCGGGCCGGG C 31

(2) INFORMATION FOR SEQ ID NO:2012: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2012: GCGCGGCCGT CBTGGCGGCG TCGGGCCGGG 30

(2) INFORMATION FOR SEQ ID NO: 2013:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2013: GCGCGGCCGT CBTGGCGGCG TCGGGCCGG 29

(2) INFORMATION FOR SEQ ID NO: 2014: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2014: GCGCGGCCGT CBTGGCGGCG TCGGGCCG 28

(2) INFORMATION FOR SEQ ID NO:2015: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2015: GCGCGGCCGT CBTGGCGGCG TCGGGCC 27

(2) INFORMATION FOR SEQ ID NO:2016: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2016: GCGCGGCCGT CBTGGCGGCG TCGGGC 26

(2) INFORMATION FOR SEQ ID NO: 2017: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid t l-109 519

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2017: GCGCGGCCGT CBTGGCGGCG TCGGG 25

(2) INFORMATION FOR SEQ ID NO:2018: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2018: GCGCGGCCGT CBTGGCGGCG TCGG 24

(2) INFORMATION FOR SEQ ID NO: 2019: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2019: GCGCGGCCGT CBTGGCGGCG TCG 23

(2) INFORMATION FOR SEQ ID NO: 2020: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH. 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2020: GCGCGGCCGT CBTGGCGGCG TC 22

(2) INFORMATION FOR SEQ ID NO: 2021: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2021: GCGCGGCCGT CBTGGCGGCG T 21

(2) INFORMATION FOR SEQ ID NO: 2022: d) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2022: GCGCGGCCGT CBTGGCGGCG 20

(2) INFORMATION FOR SEQ ID NO:2023: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2023: GCGCGGCCGT CBTGGCGGC 19

(2) INFORMATION FOR SEQ ID NO:2024: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: Single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2024: GCGCGGCCGT CBTGGCGG 18

(2) INFORMATION FOR SEQ ID NO: 2025: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 2025:

GCGCGGCCGT CBTGGCG 17

(2) INFORMATION FOR SEQ ID NO:2026: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2026: GCGCGGCCGT CBTGGC 16

(2) INFORMATION FOR SEQ ID NO: 2027: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2027: GCGCGGCCGT CBTGG 15

(2) INFORMATION FOR SEQ ID NO: 2028: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2028: GCGCGGCCGT CBTG 14

(2) INFORMATION FOR SEQ ID NO: 2029: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2029: GCGCGGCCGT CBT 13

(2) INFORMATION FOR SEQ ID NO: 2030: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2030: GCGCGGCCGT CB 12

(2) INFORMATION FOR SEQ ID NO:2031: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO.-2031: GCGCGGCCGT C 11

(2) INFORMATION FOR SEQ ID NO: 2032: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2032: GCGCGGCCGT 10

(2) INFORMATION FOR SEQ ID NO: 2033: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH. 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2033. CGCGGCCGTC BTGGCGGCGT CGGGCCGGGC ₃0

(2) INFORMATION FOR SEQ ID NO: 2034- bPl-109 521

(l) SEQUENCE CHARACTERISTICS.

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2034: GCGGCCGTCB TGGCGGCGTC GGGCCGGGC 29

(2) INFORMATION FOR SEQ ID NO: 2035: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2035: CGGCCGTCBT GGCGGCGTCG GGCCGGGC 28

(2) INFORMATION FOR SEQ ID NO: 2036: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2036: GGCCGTCBTG GCGGCGTCGG GCCGGGC 27

(2) INFORMATION FOR SEQ ID NO: 2037: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 2037: GCCGTCBTGG CGGCGTCGGG CCGGGC 26

(2) INFORMATION FOR SEQ ID NO: 2038: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2038: CCGTCBTGGC GGCGTCGGGC CGGGC 25

(2) INFORMATION FOR SEQ ID NO:2039: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2039: CGTCBTGGCG GCGTCGGGCC GGGC 24

(2) INFORMATION FOR SEQ ID NO:2040: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2040: GTCBTGGCGG CGTCGGGCCG GGC 23

(2) INFORMATION FOR SEQ ID NO:2041: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 2041: TCBTGGCGGC GTCGGGCCGG GC 22

(2) INFORMATION FOR SEQ ID NO: 2042: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH. 21 base pairs

(B) TYPE: nucleic acid EPI-109 522

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2042: CBTGGCGGCG TCGGGCCGGG C 21

(2) INFORMATION FOR SEQ ID NO: 2043: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO:2043: BTGGCGGCGT CGGGCCGGGC 20

(2) INFORMATION FOR SEQ ID NO: 2044: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2044: TGGCGGCGTC GGGCCGGGC 19

(2) INFORMATION FOR SEQ ID NO: 2045: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2045: GGCGGCGTCG GGCCGGGC 18

(2) INFORMATION FOR SEQ ID NO:2046: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2046: GCGGCGTCGG GCCGGGC 17

(2) INFORMATION FOR SEQ ID NO: 2047: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2047: CGGCGTCGGG CCGGGC 16

(2) INFORMATION FOR SEQ ID NO: 2048: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2048: GGCGTCGGGC CGGGC 15

(2) INFORMATION FOR SEQ ID NO:2049: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2049: GCGTCGGGCC GGGC 14

(2) INFORMATION FOR SEQ ID NO: 2050: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2050: EPI-109 523

CGTCGGGCCG GGC 1₃

(2) INFORMATION FOR SEQ ID NO: 2051: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 2051: GTCGGGCCGG GC 12

(2) INFORMATION FOR SEQ ID NO: 2052: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2052: TCGGGCCGGG C 11

(2) INFORMATION FOR SEQ ID NO: 2053: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2053: CGGGCCGGGC 10

(2) INFORMATION FOR SEQ ID NO.-2054: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2054: CCGCBGGCCB GGGCGCGCCG CCGGCCGGGC CG 32

(2) INFORMATION FOR SEQ ID NO: 2055: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2055: CCGCBGGCCB GGGCGCGCCG CCGGCCGGGC C 31

(2) INFORMATION FOR SEQ ID NO: 2056: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2056: CCGCBGGCCB GGGCGCGCCG CCGGCCGGGC 30

(2) INFORMATION FOR SEQ ID NO: 2057: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2057: CCGCBGGCCB GGGCGCGCCG CCGGCCGGG 29

(2) INFORMATION FOR SEQ ID NO: 2058: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2058: CCGCBGGCCB GGGCGCGCCG CCGGCCGG 28

(2) INFORMATION FOR SEQ ID NO: 2059: O 00/09525

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2059: CCGCBGGCCB GGGCGCGCCG CCGGCCG 27

(2) INFORMATION FOR SEQ ID NO: 2060: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2060: CCGCBGGCCB GGGCGCGCCG CCGGCC 26

(2) INFORMATION FOR SEQ ID NO: 2061: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2061: CCGCBGGCCB GGGCGCGCCG CCGGC 25

(2) INFORMATION FOR SEQ ID NO:2062: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2062: CCGCBGGCCB GGGCGCGCCG CCGG 24

(2) INFORMATION FOR SEQ ID NO: 2063: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2063: CCGCBGGCCB GGGCGCGCCG CCG 23

(2) INFORMATION FOR SEQ ID NO:2064: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2064: CCGCBGGCCB GGGCGCGCCG CC 22

(2) INFORMATION FOR SEQ ID NO: 2065: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2065: CCGCBGGCCB GGGCGCGCCG C 21

(2) INFORMATION FOR SEQ ID NO: 2066: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2066: CCGCBGGCCB GGGCGCGCCG 20

(2) INFORMATION FOR SEQ ID NO: 2067: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid 00

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2067: CCGCBGGCCB GGGCGCGCC 19

(2) INFORMATION FOR SEQ ID NO: 2068: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2068: CCGCBGGCCB GGGCGCGC 18

(2) INFORMATION FOR SEQ ID NO:2069: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2069: CCGCBGGCCB GGGCGCG 17

(2) INFORMATION FOR SEQ ID NO:2070: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2070: CCGCBGGCCB GGGCGC 16

(2) INFORMATION FOR SEQ ID NO: 2071: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2071: CCGCBGGCCB GGGCG 15

(2) INFORMATION FOR SEQ ID NO: 2072: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2072: CCGCBGGCCB GGGC 14

(2) INFORMATION FOR SEQ ID NO: 2073: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2073: CCGCBGGCCB GGG 13

(2) INFORMATION FOR SEQ ID NO: 2074: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2074: CCGCBGGCCB GG 12

(2) INFORMATION FOR SEQ ID NO: 2075: d) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2075:

CCGCBGGCCB G 11

(2) INFORMATION FOR SEQ ID NO: 2076: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2076: CCGCBGGCCB 10

(2) INFORMATION FOR SEQ ID NO:2077: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2077: CCGCBGGCC 9

(2) INFORMATION FOR SEQ ID NO: 2078: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2078: CGCBGGCCBG GGCGCGCCGC CGGCCGGGCC G 31

(2) INFORMATION FOR SEQ ID NO: 2079: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2079: GCBGGCCBGG GCGCGCCGCC GGCCGGGCCG 30

(2) INFORMATION FOR SEQ ID NO:2080: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2080: CBGGCCBGGG CGCGCCGCCG GCCGGGCCG 29

(2) INFORMATION FOR SEQ ID NO: 2081: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2081: BGGCCBGGGC GCGCCGCCGG CCGGGCCG 28

(2) INFORMATION FOR SEQ ID NO: 2082: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2082: GGCCBGGGCG CGCCGCCGGC CGGGCCG 27

(2) INFORMATION FOR SEQ ID NO: 2083: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2083: GCCBGGGCGC GCCGCCGGCC GGGCCG 26

(2) INFORMATION FOR SEQ ID NO: 2084: -....-, 527

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2084: CCBGGGCGCG CCGCCGGCCG GGCCG 25

(2) INFORMATION FOR SEQ ID NO: 2085: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2085: CBGGGCGCGC CGCCGGCCGG GCCG 24

(2) INFORMATION FOR SEQ ID NO: 2086: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2086: BGGGCGCGCC GCCGGCCGGG CCG 23

(2) INFORMATION FOR SEQ ID NO:2087: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2087: GGGCGCGCCG CCGGCCGGGC CG 22

(2) INFORMATION FOR SEQ ID NO: 2088: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2088: GGCGCGCCGC CGGCCGGGCC G 21

(2) INFORMATION FOR SEQ ID NO: 2089: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2089: GCGCGCCGCC GGCCGGGCCG 20

(2) INFORMATION FOR SEQ ID NO:2090: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2090: CGCGCCGCCG GCCGGGCCG 19

(2) INFORMATION FOR SEQ ID NO: 2091: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2091: GCGCCGCCGG CCGGGCCG 18

(2) INFORMATION FOR SEQ ID NO: 2092: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid J---1 l"IW7 528

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2092: CGCCGCCGGC CGGGCCG 17

(2) INFORMATION FOR SEQ ID NO: 2093: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2093: GCCGCCGGCC GGGCCG 16

(2) INFORMATION FOR SEQ ID NO: 2094: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2094: CCGCCGGCCG GGCCG 15

(2) INFORMATION FOR SEQ ID NO:2095: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO.-2095: CGCCGGCCGG GCCG 14

(2) INFORMATION FOR SEQ ID NO:2096: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 2096: GCCGGCCGGG CCG 13

(2) INFORMATION FOR SEQ ID NO: 2097: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2097: CCGGCCGGGC CG 12

(2) INFORMATION FOR SEQ ID NO:2098: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2098: CGGCCGGGCC G 11

(2) INFORMATION FOR SEQ ID NO:2099: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2099: GGCCGGGCCG 10

(2) INFORMATION FOR SEQ ID NO: 2100: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2100: ,..-._^^ 529

GGGCGCBGGC TCCGCB 16

(2) INFORMATION FOR SEQ ID NO: 2101: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 46 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2101: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT TGCCCGCCCG GCCCGG 46

(2) INFORMATION FOR SEQ ID NO: 2102: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 45 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2102: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT TGCCCGCCCG GCCCG 45

(2) INFORMATION FOR SEQ ID NO: 2103: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 44 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2103: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT TGCCCGCCCG GCCC 44

(2) INFORMATION FOR SEQ ID NO:2104: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 43 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2104: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT TGCCCGCCCG GCC 43

(2) INFORMATION FOR SEQ ID NO: 2105: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 42 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2105: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT TGCCCGCCCG GC 42

(2) INFORMATION FOR SEQ ID NO: 2106: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 41 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2106: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT TGCCCGCCCG G 41

(2) INFORMATION FOR SEQ ID NO:2107: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 40 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2107: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT TGCCCGCCCG 40

(2) INFORMATION FOR SEQ ID NO:2108: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 39 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2108: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT TGCCCGCCC 9

(2) INFORMATION FOR SEQ ID NO:2109. cπ-iυy 530

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 38 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2109: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT TGCCCGCC 38

(2) INFORMATION FOR SEQ ID NO: 2110: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 37 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2110: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT TGCCCGC 37

(2) INFORMATION FOR SEQ ID NO: 2111: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 36 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: Single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2111: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT TGCCCG 36

(2) INFORMATION FOR SEQ ID NO: 2112: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 35 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2112: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT TGCCC 35

(2) INFORMATION FOR SEQ ID NO: 2113: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2113: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT TGCC 34

(2) INFORMATION FOR SEQ ID NO: 2114: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2114: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT TGC 3₃

(2) INFORMATION FOR SEQ ID NO:2115: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2115: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT TG ₃₂

(2) INFORMATION FOR SEQ ID NO: 2116: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO:2116: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT T ₃1

(2) INFORMATION FOR SEQ ID NO: 2117: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2117: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT 30

(2) INFORMATION FOR SEQ ID NO: 2118: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2118: GGGCCCCTGG CTCGGCCCCG CGGCCCGGC 29

(2) INFORMATION FOR SEQ ID NO:2119: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2119: GGGCCCCTGG CTCGGCCCCG CGGCCCGG 28

(2) INFORMATION FOR SEQ ID NO:2120: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2120: GGGCCCCTGG CTCGGCCCCG CGGCCCG 27

(2) INFORMATION FOR SEQ ID NO: 2121: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2121: GGGCCCCTGG CTCGGCCCCG CGGCCC 26

(2) INFORMATION FOR SEQ ID NO: 2122: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2122: GGGCCCCTGG CTCGGCCCCG CGGCC 25

(2) INFORMATION FOR SEQ ID NO: 2123: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2123: GGGCCCCTGG CTCGGCCCCG CGGC 24

(2) INFORMATION FOR SEQ ID NO:2124: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2124: GGGCCCCTGG CTCGGCCCCG CGG 23

(2) INFORMATION FOR SEQ ID NO:2125: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 2125- bPl-109 532

GGGCCCCTGG CTCGGCCCCG CG 22

(2) INFORMATION FOR SEQ ID NO:2126: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2126: GGGCCCCTGG CTCGGCCCCG C 21

(2) INFORMATION FOR SEQ ID NO:2127: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2127: GGGCCCCTGG CTCGGCCCCG 20

(2) INFORMATION FOR SEQ ID NO: 2128: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 2128: GGGCCCCTGG CTCGGCCCC 19

(2) INFORMATION FOR SEQ ID NO:2129: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2129: GGGCCCCTGG CTCGGCCC 18

(2) INFORMATION FOR SEQ ID NO:2130: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2130: GGGCCCCTGG CTCGGCC 17

(2) INFORMATION FOR SEQ ID NO: 2131: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2131: GGGCCCCTGG CTCGGC 16

(2) INFORMATION FOR SEQ ID NO: 2132: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 2132: GGGCCCCTGG CTCGG 15

(2) INFORMATION FOR SEQ ID NO: 2133: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2133: GGGCCCCTGG CTCG 1₄

(2) INFORMATION FOR SEQ ID NO:2134: EPI-109 533

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2134: GGGCCCCTGG CTC 1

(2) INFORMATION FOR SEQ ID NO: 2135: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2135: GGGCCCCTGG CT 12

(2) INFORMATION FOR SEQ ID NO: 2136: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 45 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2136: GGCCCCTGGC TCGGCCCCGC GGCCCGGCTT GCCCGCCCGG CCCGG 45

(2) INFORMATION FOR SEQ ID NO:2137: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 44 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2137: GCCCCTGGCT CGGCCCCGCG GCCCGGCTTG CCCGCCCGGC CCGG 44

(2) INFORMATION FOR SEQ ID NO: 2138: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 43 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2138: CCCCTGGCTC GGCCCCGCGG CCCGGCTTGC CCGCCCGGCC CGG 43

(2) INFORMATION FOR SEQ ID NO: 2139: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 42 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2139: CCCTGGCTCG GCCCCGCGGC CCGGCTTGCC CGCCCGGCCC GG 42

(2) INFORMATION FOR SEQ ID NO: 2140: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 41 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2140: CCTGGCTCGG CCCCGCGGCC CGGCTTGCCC GCCCGGCCCG G 41

(2) INFORMATION FOR SEQ ID NO:2141: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 40 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 2141: CTGGCTCGGC CCCGCGGCCC GGCTTGCCCG CCCGGCCCGG 40

(2) INFORMATION FOR SEQ ID NO: 2142: (l) SEQUENCE CHARACTERISTICS: (A> LENGTH: 39 base pairs (B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i ) SEQUENCE DESCRIPTION: SEQ ID NO: 2142: TGGCTCGGCC CCGCGGCCCG GCTTGCCCGC CCGGCCCGG 39

(2) INFORMATION FOR SEQ ID NO: 2143: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 38 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 2143: GGCTCGGCCC CGCGGCCCGG CTTGCCCGCC CGGCCCGG 38

(2) INFORMATION FOR SEQ ID NO: 2144: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 37 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2144: GCTCGGCCCC GCGGCCCGGC TTGCCCGCCC GGCCCGG 37

(2) INFORMATION FOR SEQ ID NO:2145: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 36 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2145: CTCGGCCCCG CGGCCCGGCT TGCCCGCCCG GCCCGG 36

(2) INFORMATION FOR SEQ ID NO:2146: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 35 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2146: TCGGCCCCGC GGCCCGGCTT GCCCGCCCGG CCCGG 35

(2) INFORMATION FOR SEQ ID NO: 2147: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2147: CGGCCCCGCG GCCCGGCTTG CCCGCCCGGC CCGG 34

(2) INFORMATION FOR SEQ ID NO: 2148: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2148: GGCCCCGCGG CCCGGCTTGC CCGCCCGGCC CGG 33

(2) INFORMATION FOR SEQ ID NO: 2149: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2149: GCCCCGCGGC CCGGCTTGCC CGCCCGGCCC GG 32

(2) INFORMATION FOR SEQ ID NO:2150: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2150: EPI-109 535

CCCCGCGGCC CGGCTTGCCC GCCCGGCCCG G ₃1

(2) INFORMATION FOR SEQ ID NO: 2151: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2151: CCCGCGGCCC GGCTTGCCCG CCCGGCCCGG ₃0

(2) INFORMATION FOR SEQ ID NO:2152: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2152: CCGCGGCCCG GCTTGCCCGC CCGGCCCGG 29

(2) INFORMATION FOR SEQ ID NO: 2153: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 153: CGCGGCCCGG CTTGCCCGCC CGGCCCGG 28

(2) INFORMATION FOR SEQ ID NO:2154: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2154: GCGGCCCGGC TTGCCCGCCC GGCCCGG 27

(2) INFORMATION FOR SEQ ID NO: 2155: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2155: CGGCCCGGCT TGCCCGCCCG GCCCGG 26

(2) INFORMATION FOR SEQ ID NO: 2156: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2156: GGCCCGGCTT GCCCGCCCGG CCCGG 25

(2) INFORMATION FOR SEQ ID NO:2157: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2157: GCCCGGCTTG CCCGCCCGGC CCGG 24

(2) INFORMATION FOR SEQ ID NO:2158: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2158: CCCGGCTTGC CCGCCCGGCC CGG 23

(2) INFORMATION FOR SEQ ID NO:2159: EPI-109 536

(1) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2159: CCGGCTTGCC CGCCCGGCCC GG 22

(2) INFORMATION FOR SEQ ID NO: 2160: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2160: CGGCTTGCCC GCCCGGCCCG G 21

(2) INFORMATION FOR SEQ ID NO: 2161: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2161: GGCTTGCCCG CCCGGCCCGG 20

(2) INFORMATION FOR SEQ ID NO:2162: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2162: GCTTGCCCGC CCGGCCCGG 19

(2) INFORMATION FOR SEQ ID NO: 2163: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2163: CTTGCCCGCC CGGCCCGG 18

(2) INFORMATION FOR SEQ ID NO: 2164: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 2164: TTGCCCGCCC GGCCCGG 17

(2) INFORMATION FOR SEQ ID NO: 2165: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2165: TGCCCGCCCG GCCCGG 16

(2) INFORMATION FOR SEQ ID NO: 2166: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2166: GCCCGCCCGG CCCGG 15

(2) INFORMATION FOR SEQ ID NO: 2167: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO:2167: CCCGCCCGGC CCGG 14

(2) INFORMATION FOR SEQ ID NO: 2168: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2168: CCGCCCGGCC CGG 13

(2) INFORMATION FOR SEQ ID NO: 2169: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2169: CGCCCGGCCC GG 12

(2) INFORMATION FOR SEQ ID NO: 2170: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2170: GCCCGGCCCG G 11

(2) INFORMATION FOR SEQ ID NO:2171: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 36 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2171: GGCGGGGGCG GCGGCGCCTG GCTCGCCTBG GGCCCC 36

(2) INFORMATION FOR SEQ ID NO: 2172: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 35 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2172: GGCGGGGGCG GCGGCGCCTG GCTCGCCTBG GGCCC 35

(2) INFORMATION FOR SEQ ID NO: 2173: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 2173: GGCGGGGGCG GCGGCGCCTG GCTCGCCTBG GGCC 34

(2) INFORMATION FOR SEQ ID NO: 2174: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2174: GGCGGGGGCG GCGGCGCCTG GCTCGCCTBG GGC 3

(2) INFORMATION FOR SEQ ID NO: 2175: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2175-

GGCGGGGGCG GCGGCGCCTG GCTCGCCTBG GG 2

(2) INFORMATION FOR SEQ ID NO:2176: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 2176: GGCGGGGGCG GCGGCGCCTG GCTCGCCTBG G ₃1

(2) INFORMATION FOR SEQ ID NO:2177: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2177: GGCGGGGGCG GCGGCGCCTG GCTCGCCTBG 30

(2) INFORMATION FOR SEQ ID NO: 2178: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2178: GGCGGGGGCG GCGGCGCCTG GCTCGCCTB 29

(2) INFORMATION FOR SEQ ID NO:2179: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2179: GGCGGGGGCG GCGGCGCCTG GCTCGCCT 28

(2) INFORMATION FOR SEQ ID NO: 2180: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2180: GGCGGGGGCG GCGGCGCCTG GCTCGCC 27

(2) INFORMATION FOR SEQ ID NO:2181: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2181: GGCGGGGGCG GCGGCGCCTG GCTCGC 26

(2) INFORMATION FOR SEQ ID NO:2182: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2182: GGCGGGGGCG GCGGCGCCTG GCTCG ₂5

(2) INFORMATION FOR SEQ ID NO: 2183: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2183: GGCGGGGGCG GCGGCGCCTG GCTC ₂₄

(2) INFORMATION FOR SEQ ID NO: 2184: EPI-109 539

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2184: GGCGGGGGCG GCGGCGCCTG GCT 23

(2) INFORMATION FOR SEQ ID NO:2185: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2185: GGCGGGGGCG GCGGCGCCTG GC 22

(2) INFORMATION FOR SEQ ID NO:2186: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2186: GGCGGGGGCG GCGGCGCCTG G 21

(2) INFORMATION FOR SEQ ID NO: 2187: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2187: GGCGGGGGCG GCGGCGCCTG 20

(2) INFORMATION FOR SEQ ID NO: 2188: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2188: GGCGGGGGCG GCGGCGCCT 19

(2) INFORMATION FOR SEQ ID NO:2189: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2189: GGCGGGGGCG GCGGCGCC 18

(2) INFORMATION FOR SEQ ID NO: 2190: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2190: GGCGGGGGCG GCGGCGC 17

(2) INFORMATION FOR SEQ ID NO: 2191: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2191: GGCGGGGGCG GCGGCG 16

(2) INFORMATION FOR SEQ ID NO: 2192: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2192: GGCGGGGGCG GCGGC 15

(2) INFORMATION FOR SEQ ID NO: 2193: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2193: GGCGGGGGCG GCGG 14

(2) INFORMATION FOR SEQ ID NO: 2194: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2194: GGCGGGGGCG GCG 13

(2) INFORMATION FOR SEQ ID NO: 2195: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2195: GGCGGGGGCG GC 12

(2) INFORMATION FOR SEQ ID NO:2196: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2196: GGCGGGGGCG G 11

(2) INFORMATION FOR SEQ ID NO: 2197: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 35 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2197: GCGGGGGCGG CGGCGCCTGG CTCGCCTBGG GCCCC 35

(2) INFORMATION FOR SEQ ID NO: 2198: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2198: CGGGGGCGGC GGCGCCTGGC TCGCCTBGGG CCCC 34

(2) INFORMATION FOR SEQ ID NO: 2199: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:2199: GGGGGCGGCG GCGCCTGGCT CGCCTBGGGC CCC ₃₃

(2) INFORMATION FOR SEQ ID NO: 2200: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2200: EPI-109 541

GGGGCGGCGG CGCCTGGCTC GCCTBGGGCC CC

(2) INFORMATION FOR SEQ ID NO:2201: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2201: GGGCGGCGGC GCCTGGCTCG CCTBGGGCCC C 31

(2) INFORMATION FOR SEQ ID NO: 2202: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2202: GGCGGCGGCG CCTGGCTCGC CTBGGGCCCC 30

(2) INFORMATION FOR SEQ ID NO: 2203: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2203: GCGGCGGCGC CTGGCTCGCC TBGGGCCCC 29

(2) INFORMATION FOR SEQ ID NO: 2204: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2204: CGGCGGCGCC TGGCTCGCCT BGGGCCCC 28

(2) INFORMATION FOR SEQ ID NO: 2205: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2205: GGCGGCGCCT GGCTCGCCTB GGGCCCC 27

(2) INFORMATION FOR SEQ ID NO:2206: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2206: GCGGCGCCTG GCTCGCCTBG GGCCCC 26

(2) INFORMATION FOR SEQ ID NO: 2207: (l) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2207: CGGCGCCTGG CTCGCCTBGG GCCCC 25

(2) INFORMATION FOR SEQ ID NO: 2208: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2208: GGCGCCTGGC TCGCCTBGGG CCCC 24

(2) INFORMATION FOR SEQ ID NO: 2209: O 00/09525 bPl-109 542

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2209: GCGCCTGGCT CGCCTBGGGC CCC 23

(2) INFORMATION FOR SEQ ID NO: 2210: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2210: CGCCTGGCTC GCCTBGGGCC CC 22

(2) INFORMATION FOR SEQ ID NO: 2211: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2211: GCCTGGCTCG CCTBGGGCCC C 21

(2) INFORMATION FOR SEQ ID NO: 2212: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2212: CCTGGCTCGC CTBGGGCCCC 20

(2) INFORMATION FOR SEQ ID NO: 2213: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2213: CTGGCTCGCC TBGGGCCCC 19

(2) INFORMATION FOR SEQ ID NO: 2214: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2214: TGGCTCGCCT BGGGCCCC 18

(2) INFORMATION FOR SEQ ID NO: 2215: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2215: GGCTCGCCTB GGGCCCC 17

(2) INFORMATION FOR SEQ ID NO: 2216: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO:2216: GCTCGCCTBG GGCCCC 16

(2) INFORMATION FOR SEQ ID NO: 2217: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid EPI-109 543

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2217: CTCGCCTBGG GCCCC 15

(2) INFORMATION FOR SEQ ID NO:2218: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2218: TCGCCTBGGG CCCC 14

(2) INFORMATION FOR SEQ ID NO:2219: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2219: CGCCTBGGGC CCC 13

(2) INFORMATION FOR SEQ ID NO.-2220: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 2220: GCCTBGGGCC CC 12

(2) INFORMATION FOR SEQ ID NO:2221: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 2221: CCTBGGGCCC C 11

(2) INFORMATION FOR SEQ ID NO: 2222: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2222: CTBGGGCCCC 10

(2) INFORMATION FOR SEQ ID NO:2223: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 2223: GGGTGGGCBC GGCGGCC 17

(2) INFORMATION FOR SEQ ID NO: 2224: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2224: GGTCGGCGBB GBGCTCGTCG TGGC 24

(2) INFORMATION FOR SEQ ID NO:2225: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2225: EPI-109 544

GGTCGGCGBB GBGCTCGTCG TGG 23

(2) INFORMATION FOR SEQ ID NO: 2226: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2226: GGTCGGCGBB GBGCTCGTCG TG 22

(2) INFORMATION FOR SEQ ID NO: 2227: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2227: GGTCGGCGBB GBGCTCGTCG T 21

(2) INFORMATION FOR SEQ ID NO: 2228: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2228: GGTCGGCGBB GBGCTCGTCG 20

(2) INFORMATION FOR SEQ ID NO: 2229: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2229: GGTCGGCGBB GBGCTCGTC 19

(2) INFORMATION FOR SEQ ID NO:2230: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2230: GGTCGGCGBB GBGCTCGT 18

(2) INFORMATION FOR SEQ ID NO:2231: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2231: GGTCGGCGBB GBGCTCG 17

(2) INFORMATION FOR SEQ ID NO: 2232: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2232: GGTCGGCGBB GBGCTC 16

(2) INFORMATION FOR SEQ ID NO: 2233: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2233: GGTCGGCGBB GBGCT 15

(2) INFORMATION FOR SEQ ID NO:2234: EPI-109 545

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2234: GGTCGGCGBB GBGC 14

(2) INFORMATION FOR SEQ ID NO:2235: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2235: GGTCGGCGBB GBG 13

(2) INFORMATION FOR SEQ ID NO: 2236: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2236: GGTCGGCGBB GB 12

(2) INFORMATION FOR SEQ ID NO:2237: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2237: GGTCGGCGBB G 11

(2) INFORMATION FOR SEQ ID NO: 2238: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2238: GTCGGCGBBG BGCTCGTCGT GGC 23

(2) INFORMATION FOR SEQ ID NO: 2239: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 2239: TCGGCGBBGB GCTCGTCGTG GC 22

(2) INFORMATION FOR SEQ ID NO: 2240: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2240: CGGCGBBGBG CTCGTCGTGG C 21

(2) INFORMATION FOR SEQ ID NO: 2241: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2241: GGCGBBGBGC TCGTCGTGGC 20

(2) INFORMATION FOR SEQ ID NO:2242: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid EPI-109 546

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2242: GCGBBGBGCT CGTCGTGGC 19

(2) INFORMATION FOR SEQ ID NO: 2243: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2243: CGBBGBGCTC GTCGTGGC 18

(2) INFORMATION FOR SEQ ID NO: 2244: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2244: GBBGBGCTCG TCGTGGC 17

(2) INFORMATION FOR SEQ ID NO: 2245: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY- linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2245: BBGBGCTCGT CGTGGC 16

(2) INFORMATION FOR SEQ ID NO:2246: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2246: BGBGCTCGTC GTGGC 15

(2) INFORMATION FOR SEQ ID NO: 2247: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2247: GBGCTCGTCG TGGC 14

(2) INFORMATION FOR SEQ ID NO:2248: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2248: BGCTCGTCGT GGC 13

(2) INFORMATION FOR SEQ ID NO:2249: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2249: GCTCGTCGTG GC 12

(2) INFORMATION FOR SEQ ID NO: 2250: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION. SEQ ID NO: 2250 EPI-109 547

CTCGTCGTGG C 11

(2) INFORMATION FOR SEQ ID NO: 2251: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2251: TCGTCGTGGC 10

(2) INFORMATION FOR SEQ ID NO: 2252: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2252: GGGGCCCCGC GCCGCCCGCC 20

(2) INFORMATION FOR SEQ ID NO: 2253: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2253: GGGGCCCCGC GCCGCCCGC 19

(2) INFORMATION FOR SEQ ID NO:2254: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2254: GGGGCCCCGC GCCGCCCG 18

(2) INFORMATION FOR SEQ ID NO:2255: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2255: GGGGCCCCGC GCCGCCC 17

(2) INFORMATION FOR SEQ ID NO: 2256: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2256: GGGGCCCCGC GCCGCC 16

(2) INFORMATION FOR SEQ ID NO:2257: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2257: GGGGCCCCGC GCCGC 15

(2) INFORMATION FOR SEQ ID NO: 2258: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2258: GGGGCCCCGC GCCG 14

(2) INFORMATION FOR SEQ ID NO:2259- EPI-109 548

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2259: GGGGCCCCGC GCC 13

(2) INFORMATION FOR SEQ ID NO: 2260: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2260: GGGGCCCCGC GC 12

(2) INFORMATION FOR SEQ ID NO:2261: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2261: GGGCCCCGCG CCGCCCGCC 19

(2) INFORMATION FOR SEQ ID NO: 2262: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2262: GGCCCCGCGC CGCCCGCC 18

(2) INFORMATION FOR SEQ ID NO: 2263: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2263: GCCCCGCGCC GCCCGCC 17

(2) INFORMATION FOR SEQ ID NO: 2264: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2264: CCCCGCGCCG CCCGCC 16

(2) INFORMATION FOR SEQ ID NO: 2265: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2265: CCCGCGCCGC CCGCC 15

(2) INFORMATION FOR SEQ ID NO:2266: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2266: CCGCGCCGCC CGCC 14

(2) INFORMATION FOR SEQ ID NO: 2267: (l) SEQUENCE CHARACTERISTICS: (A; LENGTH: 13 base pairs (B) TYPE: nucleic acid EPI-109 549

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2267: CGCGCCGCCC GCC 13

(2) INFORMATION FOR SEQ ID NO: 2268: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2268: GCGCCGCCCG CC 12

(2) INFORMATION FOR SEQ ID NO:2269: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2269: CGCCGCCCGC C 11

(2) INFORMATION FOR SEQ ID NO: 2270: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: Single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2270: GCCGCCCGCC 10

(2) INFORMATION FOR SEQ ID NO:2271: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2271: GGGGCGCGCG GGGCCGCCGG G 21

(2) INFORMATION FOR SEQ ID NO:2272: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2272: GGCGGGGBGC GGCBGGGCCC GGGCCC 26

(2) INFORMATION FOR SEQ ID NO: 2273: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2273: GGCGCGTCGC CGTCGCCCCB GTCGGGCTCG CGC 33

(2) INFORMATION FOR SEQ ID NO:2274: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2274: GCGCGGGCBB CBGCGBGCCG GGCGCG 26

(2) INFORMATION FOR SEQ ID NO:2275: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single (D; TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2275: EPI-109 550

GCGCBCGGGC CCBCCTGCGC GGGC 24

(2) INFORMATION FOR SEQ ID NO:2276: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2276: GGGCGGGGTG GGCTGCCCTG CGGCCGCC 28

(2) INFORMATION FOR SEQ ID NO: 2277: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2277: GGGCTGCTGC GCGGCGGCTC CGGCGA 26

(2) INFORMATION FOR SEQ ID NO: 2278: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2278: CTCCCGGGCG GGGCCGGGCG CGGGG 25

(2) INFORMATION FOR SEQ ID NO:2279: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2279: GGGCTGCCGC GGTCCGGGCC CCTCTTGCCG GCG 33

(2) INFORMATION FOR SEQ ID NO: 2280: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2280: GCGCTCGCGC CGCTGCCGG 19

(2) INFORMATION FOR SEQ ID NO:2281: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2281: GCGCCGCTTG GCCTTGTCGC GGC 23

(2) INFORMATION FOR SEQ ID NO: 2282: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2282: GCTGCTCCBC GCGCTGG 17

(2) INFORMATION FOR SEQ ID NO: 2283: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2283: GCCGGBGGCC GGCCBGGTCC CGCG 24

(2) INFORMATION FOR SEQ ID NO:2284: EPI-109 551

(1) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2284: CCCGGCGGCC GGCBGGBBGG GCGGGCTGGG C 31

(2) INFORMATION FOR SEQ ID NO:2285: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2285: GTCTCTCCCG CCCCGGCCGC GCG 23

(2) INFORMATION FOR SEQ ID NO:2286: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2286: GGGCGTCCGC TCCGGGCCGT CGGG 24

(2) INFORMATION FOR SEQ ID NO: 2287: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2287: GCGGGCACGC GGCGGCTCTG GCGTCGGC 28

(2) INFORMATION FOR SEQ ID NO: 2288: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 681 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2288:

GGTGBCBTTG BGCBTGTCGG CGCGGTCCCG TTBBGBGTGG GCCCGCCAGC CCAGCCACTC 60

CACTTGGGGG CGGGTGGCCA GCACGAACAG CACCCAGAGG AAGGGGGGCG GCCCAGAAGG 120

GCAGCCCGCA GGCCAGGATC AGGTCTGCTG CGGCCGGAGA TAATGGCATT CACCACGCGG 180

CGGCCCAGCG CACGCCGCGC ATCCGGCCCG GGTTCTGACC TGCAGCCCCC GTCTCCTTGG 240

CATTCCTGGG CCCCAGTCAC TCCTCTCCCT GCCCCCCTTG CTGGGGCAGG GACGGGGTGB 300

CBTTGBGCBT GTCGGCGCGG TCCCGTTBBG BGTGGGCCCG CCAGCCCAGC CACTCCACTT 360

GGGGGCGGGT GGCCAGCACG AACAGCACCC AGAGGAAGGG GGGCGGCCCA GAAGGGCAGC 420

CCGCAGGCCA GGATCAGGTC TGCTGCGGCC GGAGATAATG GCATTCACCA CGCGGCGGCC 480

CAGCGCACGC CGCGCATCCG GCCCGGGTTC TGACCTGCAG CCCCCGTCTC CTTGGCATTC 540

CTGGGCCCCA GTCACTCCTC TCCCTGCCCC CCTTGCTGGG GCAGGGACGG CCGTGTTGTC 600

BGTGGTGCTG CCCGTTTGBG GTBTGGCGCT CCBCCBBTTC CCTTTTCTCC TTGTTTTCCG 660

TTTCTCTTGC CGTCTGTGGT T 681

(2) INFORMATION FOR SEQ ID NO:2289: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2289: GGTGBCBTTG BGCBTGTCGG CGC 23

(2) INFORMATION FOR SEQ ID NO: 2290: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2290: GGTCCCGTTB BGBGTGGGCC C 21

(2) INFORMATION FOR SEQ ID NO:2291: 'l) SEQUENCE CHARACTERISTICS: EPI-109 552

(A) LENGTH. 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2291: GCCAGCCCAG CCACTCCACT TGGGGGC 27

(2) INFORMATION FOR SEQ ID NO: 2292: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 38 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2292: GGGTGGCCAG CACGAACAGC ACCCAGAGGA AGGGGGGC 38

(2) INFORMATION FOR SEQ ID NO: 2293: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 46 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2293: GGCCCAGAAG GGCAGCCCGC AGGCCAGGAT CAGGTCTGCT GCGGCC 46

(2) INFORMATION FOR SEQ ID NO:2294: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2294: GGAGATAATG GCATTCACCA CGCGGC 26

(2) INFORMATION FOR SEQ ID NO: 2295: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2295: GGCCCAGCGC ACGCCGCGCA TCCGGCCC 28

(2) INFORMATION FOR SEQ ID NO:2296: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2296: GGGTTCTGAC CTGCAGCCCC C 21

(2) INFORMATION FOR SEQ ID NO:2297: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2297: GTCTCCTTGG CATTCCTGGG CCC 23

(2) INFORMATION FOR SEQ ID NO: 2298: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2298: CAGTCACTCC TCTCCCTGCC CCC 23

(2) INFORMATION FOR SEQ ID NO:2299: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single EPI-109 553

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2299: CTTGCTGGGG CAGGGACGG 19

(2) INFORMATION FOR SEQ ID NO:2300: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 2300: GGTGBCBTTG BGCBTGTCGG CGC 23

(2) INFORMATION FOR SEQ ID NO: 2301: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 2301: GGTCCCGTTB BGBGTGGGCC C 21

(2) INFORMATION FOR SEQ ID NO: 2302: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2302: GCCAGCCCAG CCACTCCACT TGGGGGC 27

(2) INFORMATION FOR SEQ ID NO:2303: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 38 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2303: GGGTGGCCAG CACGAACAGC ACCCAGAGGA AGGGGGGC 38

(2) INFORMATION FOR SEQ ID NO: 2304: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 46 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2304: GGCCCAGAAG GGCAGCCCGC AGGCCAGGAT CAGGTCTGCT GCGGCC 46

(2) INFORMATION FOR SEQ ID NO:2305: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2305: GGAGATAATG GCATTCACCA CGCGGC 26

(2) INFORMATION FOR SEQ ID NO:2306: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2306: GGCCCAGCGC ACGCCGCGCA TCCGGCCC 28

(2) INFORMATION FOR SEQ ID NO: 2307: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2307: GGGTTCTGAC CTGCAGCCCC C 21 EPI-109 554

(2) INFORMATION FOR SEQ ID NO: 2308: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2308: GTCTCCTTGG CATTCCTGGG CCC 23

(2) INFORMATION FOR SEQ ID NO:2309: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2309: CAGTCACTCC TCTCCCTGCC CCC 23

(2) INFORMATION FOR SEQ ID NO:2310: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2310: CTTGCTGGGG CAGGGACGG 19

(2) INFORMATION FOR SEQ ID NO: 2311: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2311: CCGTGTTGTC BGTGGTGCTG 20

(2) INFORMATION FOR SEQ ID NO: 2312: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2312: CCCGTTTGBG GTBTGGC 17

(2) INFORMATION FOR SEQ ID NO:2313: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2313: GCTCCBCCBB TTCCCTTTTC TCC 23

(2) INFORMATION FOR SEQ ID NO: 2314: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2314: TTGTTTTCCG TTTCTCTTG 19

(2) INFORMATION FOR SEQ ID NO:2315: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2315: CCGTCTGTGG TT 12

(2) INFORMATION FOR SEQ ID NO:2316: (l) SEQUENCE CHARACTERISTICS: EPI-109 555

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2316: CCCGGCCCCG CCTCGTGCC 19

(2) INFORMATION FOR SEQ ID NO: 2317: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2317: CGTCCBTGCC GCGGGCCC 18

(2) INFORMATION FOR SEQ ID NO:2318: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2318: GCCCCGCTGC TTGGGCTGCT CTGCCGGG 28

(2) INFORMATION FOR SEQ ID NO: 2319: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2319: TCTGTGCTCC TCTCGCCTGG G 21

(2) INFORMATION FOR SEQ ID NO:2320: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2320: TGGTGGGGTG GGTCTTGGTG G 21

(2) INFORMATION FOR SEQ ID NO: 2321: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2321: CTGTCCCTGG TCCTGTG 17

(2) INFORMATION FOR SEQ ID NO: 2322: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2322: GGTCCCGCTT CTTC 14

(2) INFORMATION FOR SEQ ID NO: 2323: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2323: GGGGTTGTTG TTGGTCTGG 19

(2) INFORMATION FOR SEQ ID NO: 2324: (l) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B; TYPE: nucleic acid (C) STRANDEDNESS: single EPI-109 556

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2324: TGTCCTCTTT CTGC 14

(2) INFORMATION FOR SEQ ID NO: 2325: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2325: GCCTCGGGCC TCCC 14

(2) INFORMATION FOR SEQ ID NO: 2326: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2326: GGCTGGGGTC TGCGT 15

(2) INFORMATION FOR SEQ ID NO:2327: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2327: GGCCGGGGGT CGGTGGGTCC GCTG 24

(2) INFORMATION FOR SEQ ID NO: 2328: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2328: GGGCTGGGGT GCTGGCTTGG GG 22

(2) INFORMATION FOR SEQ ID NO:2329: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2329: GGGGCTGGGG CCTGGGCC 18

(2) INFORMATION FOR SEQ ID NO:2330: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2330: GCCTGGGTGG GCTTGGGGGC 20

(2) INFORMATION FOR SEQ ID NO: 2331: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2331: GCTGGGTCTG TGCTGTTGCC 20

(2) INFORMATION FOR SEQ ID NO: 2332: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO : 2332: GTTGTGTGGG GGGCC 15 EPI-109 557

(2) INFORMATION FOR SEQ ID NO:2333: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2333: GCTGGGTCGG GGGGCCTCTG GGCTGTC 27

(2) INFORMATION FOR SEQ ID NO: 2334: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2334: GCCCCGGGGC CCCC 14

(2) INFORMATION FOR SEQ ID NO: 2335: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2335: TGGCTCCCCC CTCC 14

(2) INFORMATION FOR SEQ ID NO:2336: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2336: GCTCCCCCCT TTCC 14

(2) INFORMATION FOR SEQ ID NO:2337: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2337: CGGACGAAGA CAGAGA 16

(2) INFORMATION FOR SEQ ID NO: 2338: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2338: GGCTTTGTGG GCTC 14

(2) INFORMATION FOR SEQ ID NO: 2339: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2339: GCCTGCTCTC CCCC 14

(2) INFORMATION FOR SEQ ID NO:2340: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2340: CCCGGCCCCG CCBCGBBCC 19

(2) INFORMATION FOR SEQ ID NO:2341: ( ) SEQUENCE CHARACTERISTICS: EPI-109 558

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2341: CCCGGCCCCG CCBCG 15

(2) INFORMATION FOR SEQ ID NO: 2342: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2342: CCCGGCCCCG CCBCGBBCC 19

(2) INFORMATION FOR SEQ ID NO: 2343: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2343: CCCGGCCCCG CCBCG 15

(2) INFORMATION FOR SEQ ID NO: 2344: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2344: CCCGBCCCCG CCTCBBG 17

(2) INFORMATION FOR SEQ ID NO: 2345: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2345: CCCGBCCCCG CCTC 14

(2) INFORMATION FOR SEQ ID NO: 2346: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2346: CCGGCCCCGC CTC 13

(2) INFORMATION FOR SEQ ID NO:2347: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2347: CCCGBBCCCG CBTBGTGCC 19

(2) INFORMATION FOR SEQ ID NO: 2348: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2348: CCCGCBTBGT GCC 13

(2) INFORMATION FOR SEQ ID NO: 23 9: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single EPI-109 559

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2349: CCCGGBCCCB CCBBGTGCC 19

(2) INFORMATION FOR SEQ ID NO: 2350: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2350: CBGBBCCCGC CTCGTGCC 18

(2) INFORMATION FOR SEQ ID NO: 2351: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2351: CCCGCCTCGT GCC 13

(2) INFORMATION FOR SEQ ID NO: 2352: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 2352: CCGGCBCCGC CTCBTGCC 18

(2) INFORMATION FOR SEQ ID NO:2353: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2353: CCGGCCCCGC CBCBTGCC 18

(2) INFORMATION FOR SEQ ID NO:2354: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2354: CCCGBCCCCG BCTCG 15

(2) INFORMATION FOR SEQ ID NO: 2355: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 2355: CCCGGCCBCG BCTCG 15

(2) INFORMATION FOR SEQ ID NO: 2356: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2356: CCCGGCCCBG CCTBG 15

(2) INFORMATION FOR SEQ ID NO: 2357: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2357: CCCGGCBCBG BCTCGTBCC 19 EPI-109 560

(2) INFORMATION FOR SEQ ID NO: 2358: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2358: CCCGGCCCCG CCBCG 15

(2) INFORMATION FOR SEQ ID NO: 2359: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2359: CCCGGCCCCG CCBCG 15

(2) INFORMATION FOR SEQ ID NO: 2360: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2360: TCCBTGCCGC GGGC 14

(2) INFORMATION FOR SEQ ID NO:2361: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 2361: TCCBTGCCBC GGGCC 15

(2) INFORMATION FOR SEQ ID NO:2362: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2362: TCCBTGCCBC GGGCC 15

(2) INFORMATION FOR SEQ ID NO:2363: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2363: TCCBTGCCBC BGGCC 15

(2) INFORMATION FOR SEQ ID NO:2364: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 2364: GTCCBTGBCG CGG 13

(2) INFORMATION FOR SEQ ID NO:2365: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2365: TCCBTGBCGC GGG 13

(2) INFORMATION FOR SEQ ID NO:2366: (l) SEQUENCE CHARACTERISTICS. EPI-109 561

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2366: TCTGBGCTCC TCTBBCCTGG G 21

(2) INFORMATION FOR SEQ ID NO: 2367: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2367: CTGTGCBCCT BBCBCCTGGG 20

(2) INFORMATION FOR SEQ ID NO: 2368: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2368: TGTGBTCCBC TBGBCTGGG 19

(2) INFORMATION FOR SEQ ID NO:2369: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2369: TCTGTBCTCB BCTCBCCTG 19

(2) INFORMATION FOR SEQ ID NO: 2370: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2370: TGCTCCTCBC BBCTGGG 17

(2) INFORMATION FOR SEQ ID NO: 2371: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2371: CTCCTCTBGC CTGG 14

(2) INFORMATION FOR SEQ ID NO: 2372: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2372: GTGCTCCBBT CBBCTGGG 18

(2) INFORMATION FOR SEQ ID NO: 2373: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2373: GTGCBCCBBT CBCCTGGG 18

(2) INFORMATION FOR SEQ ID NO: 2374: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single EPI-109 562

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2374: TCTGTGCBCC TCTBGBCT 18

(2) INFORMATION FOR SEQ ID NO: 2375: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2375: TBBTCCTBBC BCCTGG 16

(2) INFORMATION FOR SEQ ID NO: 2376: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2376: TGTGCTBBTC BCBCBTGGG 19

(2) INFORMATION FOR SEQ ID NO: 2377: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2377: GTGCBCCBCT CBCCTG 16

(2) INFORMATION FOR SEQ ID NO: 2378: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2378: CTGTGCBCCT CTC 13

(2) INFORMATION FOR SEQ ID NO: 2379: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2379: CBGTGCBCCB CTCBCCTG 18

(2) INFORMATION FOR SEQ ID NO: 2380: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2380: GTGCBCCBCT CBCCTG 16

(2) INFORMATION FOR SEQ ID NO: 2381: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2381: CBCCTCTCBC CTGGG 15

(2) INFORMATION FOR SEQ ID NO: 2382: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION. SEQ ID NO:2382: CCTCTCBCCT GGG 13 EPI-109 563

(2) INFORMATION FOR SEQ ID NO: 2383: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2383: GCTCCBCTCG CCT 13

(2) INFORMATION FOR SEQ ID NO: 2384: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2384: TGCTCCTCBC GCC 13

(2) INFORMATION FOR SEQ ID NO:2385: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2385: GTTGTTGBTC TGG 13

(2) INFORMATION FOR SEQ ID NO:2386: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2386: GGTTGBBBTT GGTCTTGG 18

(2) INFORMATION FOR SEQ ID NO: 2387: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2387: GGTTGTTGBT GBTCTG 16

(2) INFORMATION FOR SEQ ID NO: 2388: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2388: GGGTTBBBGT TGBTCTGG 18

(2) INFORMATION FOR SEQ ID NO: 2389: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2389: GGGTTBBBGT TGBTCTGG 18

(2) INFORMATION FOR SEQ ID NO: 2390: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2390: TTGTTGTBGB TCTGG 15

(2) INFORMATION FOR SEQ ID NO:2391: (l) SEQUENCE CHARACTERISTICS: EPI-109 564

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2391: GGGTBGBBGB GTCCGCTG 18

(2) INFORMATION FOR SEQ ID NO: 2392: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2392: GGGTCBGBGG BTCBGCTG 18

(2) INFORMATION FOR SEQ ID NO: 2393: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2393: GGGTBGGTGG GTC 13

(2) INFORMATION FOR SEQ ID NO: 2394: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2394: GGGTCGGBGG GTCBGC 16

(2) INFORMATION FOR SEQ ID NO: 2395: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2395: CCTGGGTGGG CTT 13

(2) INFORMATION FOR SEQ ID NO: 2396: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2396: GGGTGGGCTT GGG 13

(2) INFORMATION FOR SEQ ID NO:2397: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2397: CCTGGGTGGG BBTGGG 16

(2) INFORMATION FOR SEQ ID NO: 2398: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2398: CCTGGBTGGG CBTGGG 16

(2) INFORMATION FOR SEQ ID NO:2399: (l) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B; TYPE: nucleic acid (C) STRANDEDNESS: single EPI-109 565

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2399: GCCTGBGTGB BCTTGGG 17

(2) INFORMATION FOR SEQ ID NO: 2400: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2400: CCCAVGVCCV CCCAGGC 17

(2) INFORMATION FOR SEQ ID NO: 2401: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2401: AGCCCACCCA GGC 13

(2) INFORMATION FOR SEQ ID NO: 2402: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2402: BCCTGGGTGG GCTB 14

(2) INFORMATION FOR SEQ ID NO: 2403: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2403: GGTGGGCTTG GG 12

(2) INFORMATION FOR SEQ ID NO: 2404: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2404: CCBBGGTGGG CTTGGG 16

(2) INFORMATION FOR SEQ ID NO:2405: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2405: CTGGGTGGGB BTGGG 15

(2) INFORMATION FOR SEQ ID NO:2406: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2406: CCBGGGTGGG CTTGG 15

(2) INFORMATION FOR SEQ ID NO: 2407: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2407: GGGTGGGCTT GG 12 EPI-109 566

(2) INFORMATION FOR SEQ ID NO:2408: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2408: CCTGBGTGBG CBTGGG 16

( 2) INFORMATION FOR SEQ ID NO: 2409: (i) SEQUENCE CHARACTERISTICS: (A ) LENGTH: 7800 base- pairs (B ) TYPE: nucleic acid (C ) STRANDEDNESS: single (D ) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2409: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGGCTGGG CTGCTTTTCT 60 TTTCTGGGCC TCTGTGGTCT GTTTTTTTCT GGCCCTGCTG GGGCGCTCTC CGCCGCCCGC 120 CTGGCTCCCG GBGCCCBTGB TGGGCBTGCC GTGGTTCTTG CCCTCCTTTG GCTGCCGTGC 180 CCGCTCCCCG GCCTCCTGGC GGGTGGCCGT TGGGCCCGTG TTCCCCTGGG GCCTGGGGCT 240 CCCTTCTCTC GCCCTTCTTG CTGGGCCTCT GCTGCTGCTG GTGCTGTGGC CCCCGTACAC 300 CGAGGAGCCC ATGATGGGCA TGCCACAGAC GACAGGCGTB CBCCGBGGBG CCCBTGBTGG 360 GCBTGCCBCB GBCGBCBGGC GGCGCCGTGC CGCGTCTTGG TGGCGGCGGG TTCGCGCCCG 420 CGCGGGGCCC CTCCGGTCCG TTCGCGCCCG CGCGGGGCCC CTCCGGTCCC GGGTCGGGGC 480 CCCCCGCGGC CGCCTCGGGG CTGGGGCGCT GGTGGCCGGG CCGCGCCTCC GCCTGCCGCT 540 TCTGGCTGGG CCCCGGGCGC CCCCTCCCCT CTTGCTCGGG TCCCCGTGAC AGCGCGTCCT 600 GTGTCTCCAG CAGCATGGCC GGGCCAGCTG GGCCCCBCBG CGCGTCCTGT GTCTCCBGCB 660 GCBTGGCCGG GCCBGCTGGG CCCCACAGAG CAGTGCTGTT GTTGGGCATC TTGCCTTCCC 720 AGGGBCBGBG CBTGCTGTTG TTGGGCBTCT TGCCTTCCCB GGGCCCTTTT CTGGTGGGGT 780 GGTGCTGTTG TTGGGCTTTC TTCTGTTCCC BCBGBGCBGT GCTGTTGTTG GGCBTCTTGC 840 CTTCCCBGGG CCCTTTTCTG GTGGGGTGGT GCTGTTGTTG GGCTTTCTTC TGTTCCCTTT 900 CCCCTGGGTC TTCCCTCCTG CTCTTTTTTC ATTTGCTCTC CTATTACTTT CTGTGTCCAT 960 TTTTTCATTA ACCGAGCTGT BTTTGCTCTC CTBTTBCTTT CTGTGTCCBT TTTTTCBTTB 1020 BCCGBGCTGT GCCTGTGTCT GTCCTCCTGC TTCGTTCCTC TCGTTCCTGC TTGGTGCCCT 1080 TGCCGGTCCT GCTCCTCCGG GCTGTGGGTC GTGGCCCTGG CTCCGGCTGG TGGGCTCCCC 1140 TGGCCTTCGC TGGCTGGCGG CGTGCGGGTC TTGCTCTGGG CCTGGCTGTG GCCGTGGTTG 1200 GGGGTCTTCG CTGCCTCCGT TTGGGTGGCT CTCTGAATAT TGACCTTCCT CCATGGCGGT 1260 CCTGCTTGGA TTCTCCCGAT CTCTGBBTBT TGBCCTTCCT CCBTGGCGGT CCTGCTTGGB 1320 TTCTCCCGBG CCTTTCCTGG TTCTCTTGTT GTTTTTGGGG TTTGGCTTAC AGTAGAGTAG 1380 GGGATTCCAT GGCAGGAGCC ATCTTCTTCA TGGACTCCTT CAAGGAGACC TTAGGTTTCT 1440 GAGGGACTGC TAACACGCCA TCTGGAGCBC BGTBGBGTBG GGGBTTCCBT GGCBGGBGCC 1500 BTCTTCTTCB TGGBCTCCTT CBBGGBGBCC TTBGGTTTCT GBGGGBCTGC TBBCBCGCCB 1560 TCTGGBGCGT TGTTTTTGGG GTTTGGCTTG CCTTTCCTGG TTCTCTTBCB GTBGBGTBGG 1620 GGBTTCCBTG GCBGGBGCCB TCTTCTTCBT GGBCTCCTTC BBGGBGBCCT TBGGTTTCTG 1680 BGGGBCTGCT BBCBCGCCBT CTGGBGCGCC TGTGTCTGTC CTCCTGCTTC GTTCCTCTCG 1740 TTCCTGCTTG GTGCCCTTGC CGGTCCTGCT CCTCCGGGCT GTGGGTCCTC GCCCTGGCTC 1800 CGGCTGGTGG GCTCCCCTGG CCTTCGCTGG CTGGCGGCGT GCCCCBGBBC GBGBCCCGGB 1860 CCGBCBGGCC GTGGTTGGGG GTCTTCGCTG CCTCCGTTTG GGTGGCGATC TCTGAATATT 1920 GACCTTCCAT GGCGGTCCTG CTTGGAGBTC TCTGBBTBTT GBCCTTCCBT GGCGGTCCTG 1980 CTTGGBTCTG GGGTGTCCTG GCCTTCGTGG TTCCTCTTCC TTCGTTTGCC GTCCGCGGGG 2040 GCCCCCGGGC CTGGCTGCGC TCCTGCCCCG CCTCTTTCCC GGGCTCTTGC GCTGGGGGGT 2100 GCTCCCGTGT GTTTGCGCCC TCCTCCTGGT CGCGCTTGTC GTTTTGGGGC CGGCTTTGCC 2160 CGCCTCCCGG CGCCTGGCCC GGCCTTCCTG GGCTGCGTGC GCGTTCTGTT CTTCTTCCTG 2220 GCTCTGGGGT GTCCTGGCCT TCGTGGTTCC TCTTCCTTCG TTTGCCGTCC GCGGGGGCCC 2280 CCGGGCCTGG CTGCGCTCCT GCCCCGCCTC TTTCCCGGGC TCTTGCGCTG GGGGGTGCTC 2340 CCGTGTGTTT GCGCCCTCCT CCTGGTCGCG CTTGTCGTTT TGGGGCCGGC TTTGCCCGCC 2400 TCCCGGCGCC TGGCCCGGCC TTCCTGGGCT GCGTGCGCGT TCTGTTCTTC TTCCTGGCGC 2460 AGGAGACAGG GCAGGGCGAT CAGGAGCAGC GTGAGCCAAA GGAGGACCAT CGGGAACGCA 2520 GCTCCGGAAC GCAGGACAGA GGTGCCGCBG GBGBCBGGGC BGGGCGBTCB GGBGCBGCGT 2580 GBGCCBBBGG BGGBCCBTCG GGBBCGCBGC TCCGGBBCGC BGGBCBGBGG TGCCTCTGCC 2640 CTGTCCGCCG GCTCTTCGGI GGCTCGGCCC CGCTCCTTGT CTTGCCGCGG GTTGGTTCCT 2700 GGGCCTGGTT CTTGCGGGCG TTTCGGTCTG CTGGCTGGTC TGGGCCCGCG GTGCGGCGGG 2760 TGGCTTGCTG TTCTGCCTGG GCTCTCCCCT CTCCTCCTTT TCTCCCTTCC TCTGTCTTGC 2820 CTCCTTCCTC TGGGTCCTCT TGGCCTGGGC GCTCTTCCCC TCGGGCGGCT GCGGGCGCTC 2880 GTGCTGCCTG GTCCGCTCCC TGGGGGTGCT CCTTCCCTTT CCCCGCTCGT GGGGTTTGCG 2940 GGGCTGGGCT GCCCTGGGGG GTCTGGGCCT TTTGGGGTCG GCTGGCTGCT GCTTCGGGCC 3000 GCCTGGGCTT CCCTGTGCCC CTTTCCTCTG CTGGGTCCCC CTCCCGTTCC AAGCTGCACC 3060 GCACAGACCG GCGCTACAGG ACAGAGCCAG GCAAGCACCC ATGGGGATCC AGGCCCAGCT 3120 GTTCCBBGCT GCBCCGCBCB GBCCGGCGCT BCBGGBCBGB GCCBGGCBBG CBCCCBTGGG 3180 GBTCCBGGCC CBGCTGCTCA GTGGCCCCCA AAAGGATGAG TAATACATGC GCCACGATGA 3240 TCATATCCTT TTTACTATGA GGCCGTGTCT GTCGTGTCTT TCCTTTGCTC TTGGTGTGTC 3300 TTTGCTGTGC CCTGCCTCTC TGCCCGTGTC TGTCGTGTCT TTCCTTTGCT CTTGGTGTGT 3360 CTTTGCTGTG CCCTGCCTCT CTGCCCGTGT CTGTCGTGTC TTTCCTTTGC TCTTGGTGTG 3420 TCTTTGCTGT GCCCTGCCTC TCTGCGGGGG TGGCTTCCTG CCGCGTCTCT GGGCCGTCCC 3480 EPI-109 567

GTCCCTCGGC CCCGCGCCGC GCTCGGCTCC TCTCCCTCTG GCCCGGCTCG GGGCGGGGCG 3540 GGGCGGTGGG CGGGCGGCGC TGCCCTGCGC GCGGCGCTGG CCCCTGCTGG CCGTCGGCTG 3600 CGCGCTGCTG GCTGCCCTGC TGGCCGCGCC GGGGCCTGTC CGCCTCTGCG GGCGCTGTCT 3660 CCTGGCTTGT CTTCCGGCTC TTCTGCTGGG GTGGGGCTGG GCGGCCGGCC CGGTGCTGGG 3720 GCTCCTCGGG GGGGGGGGCT CTTCCGGGCT GTCTCCCTCC GGGGCGGGGG TTTCTGGCCG 3780 TGGGGGTCTT GCCTGGCCTC CGGGCTCCTG CTTGTCTTGC CTTCCTTCTC TGGTCGGTTG 3840 TGGCTCGGGG CTCCGTGGGT CCCTGGCGCC CGTTTGTGTT TTGTCTTTTC CCCTGGCGTC 3900 CCTGTGCCCC TCTCCTCTCC TTCCTCTGCT TCTCGCTCTC CTTTGTGGGG CCCTCCCTGC 3960 TGCTCTTGGT TTTGGGCTTT TTTTCTCTTC CTCCTTTTTC GTGCGTGGGC CTCCGCACGC 4020 CTCTTGCCAC CTCCTGCGCA GGGCAGCGCC TTGGGGCCAG CGCCGCTCCC GGCGCGGCCA 4080 GCAGGGCAGC CAGCAGCGCG CAGCCGACGG CCAGCATGCT TCCTCCTCGG CTACCACTCC 4140 ATGGTCCCGC AGAGGCGGAC AGGCGCBCGC CTCTTGCCBC CTCCTGCGCB GGGCBGCGCC 4200 TTGGGGCCBG CGCCGCTCCC GGCGCGGCCB GCBGGGCBGC CBGCBGCGCG CBGCCGBCGG 4260 CCBGCBTGCT TCCTCCTCGG CTBCCBCTCC BTGGTCCCGC BGBGGCGGBC BGGCGCTGCC 4320 CGGCGGGGTG TGCGCTTGGC GCTCCCGTGC TCGGTTCTCT GTCTCCCGGT CCCCCTTGCC 4380 TGGCGTCTCG GGCCTTCGTC CTCTTCCTCT TCTTCCTTCC GCTCCGTGGG GGCTGCTTGG 4440 TGGGGGCCTG TGCCTCGGGG TCCCGGGGCT TCTGGCCCTT GCCGTTCATG GTGGCTAGGT 4500 GGGGCGTTCB TGGTGGCTBG GTGGGGCGGG GTGGGTBGGC CGTGTCTGGG GGTTGGCCBT 4560 GTTGGTTGCC TCTTGGTGGT GCGCCGGGCG CGTCTTGGCT TTCTTCTCCT TCGGGCCCTC 4620 GGGCCGGTGC TTGTGGGCTC CTCCCGGGCG GCCTCCCCGG GCGGGGGCTT CTTGGCGCTG 4680 GCGGGGGGGC CTCCTGCTCT GTGGCTGGGC GTTCCTTGGT GTTCTGGGTG GTGGCGGGCG 4740 TGGTGGCCTC TGTGGGGGCC CGCGGCTGCB GGGGTTGCCT GTCTGCTTCG TCCTTTGCGC 4800 TCCCGGGCCG CCGGGGTGGG TAGGCCGTGT CTGGGGGTTG GCCATGTTGG TTGCCGGGCC 4860 CGCGGCTGCA GGGGACAGGG GCTGTAATCT TCATCTGCAG GTGGCATGCC AGTGAAATTT 4920 AGATCATCAA AATCCCACAT CTGTGGATCT GTAATATTTG ACATGTCCTC TTCAGTTTCA 4980 GCAATGGTTT GATCTAACTG AAGCACCGGC CAGGBCBGGG GCTGTBBTCT TCBTCTGCBG 5040 GTGGCBTGCC BGTGBBBTTT BGBTCBTCBB BBTCCCBCBT CTGTGGBTCT GTBBTBTTTG 5100 BCBTGTCCTC TTCBGTTTCB GCBBTGGTTT GBTCTBBCTG BBGCBCCGGC CBGGTGGCTC 5160 GGTGCTTCTG CCCCTGTTGT TGCGGCGCTC GGTTGGTGTG GCCCCTGTGG TGCTTCGTTT 5220 CCCCCTCTTT CTCTTTGTTC GGGGGTTCTT GTGGCGGGCT GCTTGTCTCG TTCCGCCCTG 5280 TCGGGCGGGA AGCCTCTCTC CTCTCCCCAG ATCCGCGACA GGCCGCAGGC AAGAACCAGC 5340 GCAACCAGGG CGCGTCCGCA CAGACTTGGA GGCGGCTGCA TGCTGCTACC TGCTCCAGAA 5400 GCGTCCGGTG GCCGCCGCGC CCTGTCGGGC GGGBBGCCTC TCTCCTCTCC CCBGBTCCGC 5460 GBCBGGCCGC BGGCBBGBBC CBGCGCBBCC BGGGCGCGTC CGCBCBGBCT TGGBGGCGGC 5520 TGCBTGCTGC TBCCTGCTCG GGCGGGBBGC CTCCGGTGGC CGCCGCGCGT CCGGTGGCCG 5580 CCGCGCCTCT CTCCTCTCCC CGTGGCCCTG TCGGGCGGGT CCTGCCGTCC TGTCTCCTTT 5640 TCTTTTGCTG TCTTGTCTTC CCGTCTCTGC TTTGTCTGTC CTCCCCGTCT CCTCCCACTG 5700 CTTCTCCCGG GGGCTTCCCC GGCTTCGGGT GGCCGGTGTC CCGGGCTCCG GCGCGGCGGC 5760 GGCTTCGGCT GCGGGTGGGT GGCGCGGGCT GCCGGGTCCG CGCGGCGCCT GGGCCCTTGT 5820 GCTGCTTTTT GCTTGTTCCG TTCTGGCTGC TCCGGTCTGT GTTGTGGTTG TTTTGTTTCT 5880 TCTTGGGTGT GGGCCTTGCG GTTTTGGCTG TGGGCCCTTT GGGGCCTTGG CTTCTGGCTC 5940 GTCTGTCCTC CCCGTCTCCT CCCACTGCTT CTCCCGGGGG CTTCCCCGGC TTCGGGTGGC 6000 CGGTGTCCCG GGCTCCGGCG CGGCGGCGGC TTCGGCTGCG GGTGGGTGGC GCGGGCTGCC 6060 GGGTCCGCGC GGCGCCTGGG CCCTTGTGCT GCTTTTTGCT TGTTCCGTTC TGGCTGCTCC 6120 GGTCTGTGTT GTGGTTGTTT TGTTTCTTCT TGGGTGTGGG CCTTGCGGTT TTGGCTGTGG 6180 GCCCTTTGGG GCCTTGGCTT CTGGCTCCAT CCACATGATT GCTTAGATTT GTGCTGTATC 6240 TCTCAGGATT ATCACTGATT ACACATCCAA CCAGTGCCAG CCAAAAGGAT GCCCTGAGGC 6300 AAAGGGTTTC CATCTTGAGG CAAATTTGAG GACBTCCBCB TGBTTGCTTB GBTTTGTGCT 6360 GTBTCTCTCB GGBTTBTCBC TGBTTBCBCB TCCBBCCBGT GCCBGCCBBB BGGBTGCCCT 6420 GBGGCBBBGG GTTTCCBTCT TGBGGCBBBT TTGBGGBGGG CTBBGBTGBT CCBCBTCBCT 6480 BCCBCGTTGC CCBCCBCBGB GGTCBCCBCB BTGBCCGTGT BGGCBGCTGC CCBBBGGBCB 6540 BTTTGCCBGG CTGGTTGCBC GBBCTGBTTG GGTTCCGBGG TGTTBGTGGB GBTGTTTGGG 6600 GBGBGGTCTG BGTCCBCCGG GBGGBCGTTB TCCBTTTCGB BGCTBGGCGG TBBBGCCCTB 6660 CTBTCTGTBC BCBBCCCCCC TCTGCBGCBG BGTCCTGTCG TGGCGCCTGG GGCTCBGGGT 6720 CCGGGCTAAG ATGATCCACA TCACTACCAC GTTGCCCACC ACAGAGGTCA CCACAATGAC 6780 CGTGTAGGCA GCTGCCCAAA GGACAATTTG CCAGGCTGGT TGCACGAACT GATTGGGTTC 6840 CGAGGTGTTA GTGGAGATGT TTGGGGAGAG GTCTGAGTCC ACCGGGAGGA CGTTATCCAT 6900 TTCGAAGCTA GGCGGTAAAG CCCTACTATC TGTACACAAC CCCCCTCTGC AGCAGAGTCC 6960 TGTCGTGGCG CCTGGGGCTC AGGGTCCGTC CTGTCGTGGC GCCTGGGGCT CTTCTTTTGT 7020 GGGCTCTTTG GTGGCTGTGG CTGTGGTCTC TGTGGTTGCT GCCCTGGGTC TGGGGGTGTG 7080 GCCTTGGGGC CGTCCTCTGG CTCCTCCTCG TGGGCCCCCG GTGBCBTTGB GCBTGTCGGC 7140 GCGGTCCCGT TBBGBGTGGG CCCGCCAGCC CAGCCACTCC ACTTGGGGGC GGGTGGCCAG 7200 CACGAACAGC ACCCAGAGGA AGGGGGGCGG CCCAGAAGGG CAGCCCGCAG GCCAGGATCA 7260 GGTCTGCTGC GGCCGGAGAT AATGGCATTC ACCACGCGGC GGCCCAGCGC ACGCCGCGCA 7320 TCCGGCCCGG GTTCTGACCT GCAGCCCCCG TCTCCTTGGC ATTCCTGGGC CCCAGTCACT 7380 CCTCTCCCTG CCCCCCTTGC TGGGGCAGGG ACGGGGTGBC BTTGBGCBTG TCGGCGCGGT 7440 CCCGTTBBGB GTGGGCCCGC CAGCCCAGCC ACTCCACTTG GGGGCGGGTG GCCAGCACGA 7500 ACAGCACCCA GAGGAAGGGG GGCGGCCCAG AAGGGCAGCC CGCAGGCCAG GATCAGGTCT 7560 GCTGCGGCCG GAGATAATGG CATTCACCAC GCGGCGGCCC AGCGCACGCC GCGCATCCGG 7620 CCCGGGTTCT GACCTGCAGC CCCCGTCTCC TTGGCATTCC TGGGCCCCAG TCACTCCTCT 7680 CCCTGCCCCC CTTGCTGGGG CAGGGACGGC CGTGTTGTCB GTGGTGCTGC CCGTTTGBGG 7740 TBTGGCGCTC CBCCBBTTCC CTTTTCTCCT TGTTTTCCGT TTCTCTTGCC GTCTGTGGTT 7800

(2) INFORMATION FOR SEQ ID NO: 2410: (i) SEQUENCE CHARACTERISTICS: EPI-109 568

(A ) LENGTH : 6225 base pa. (B ) TYPE : nucleic acid (C ) STRANDEDNESS : single (D ) TOPOLOGY : linear (xi) SEQUENCE DESCRIPTION : SEQ ID NO:; 2410: CTTGCTCCTG GGGGCCTCCT GGTCCCTCTG GCTGTTCCCG GCCCTGGBCT GGGGCBGGGG 60 CCGCGTBGGC GCGGCTCGCC BGGBCGGGCB GCGCCBGCBG CBGCBGGCTC BGCBTCCTGG 120 CCBCGGBBTT CCGGTGTGCG GGGCCTGGTG CCCCTGGGCC TCGGGTGCTG CCTGTGCGCT 180 GCCTTCTTCT CCTGGGTCCT CGCCGGGGCC CTTGCTGCCC TGGCTGTGCC CTGGGGGTCT 240 GGGTTCGGCT GTCCCCBGCB GGBCCBGTCC CBTCCBCBGC GTGTGBTGBG TBGCCBTTCT 300 CCTGCBGCCG BGGGGCGCGG GCGBGCBTCG CTTTGGGCTT TTCTCCTTTG GTTTGBGCGC 360 CBGGBCCGCG CBCBGCBGCB GGGCGCGGGC GBGCBTCGCB GCGGCGGGCB GGGGGGCTCC 420 CGCCGCGBGB GGTTBTGGGC TCCCBGGBCC BCCCGCBCCG CGCGGBCGTT TBCBTTCGCC 480 BCGCBGTGCG CGGCCGBCBT GBCGBBGTTG GGCGCBBTCB GGGTGGCGCC GCBGBBGTGG 540 CCTCCGCGCB GCTGCBGGGB CBCCBTGBBG GGCCBCGCGT GGGGCCGCGC TCGCCGGCCC 600 CCCBCBBTCT CCGBGGCCBG CGCGGTGCCC CCCBGCBGCB BGGCCGGCBG GBCBCBGGCG 660 BGGBGBCBCG CGBGTCGGCG GCCGBGGGTC BTGGTGGGGC TGGGGCTCCG GGGTCTCTGC 720 CCCTCCGTGC TGGTGGGGCT GGGGCTCCGG GGTCTCTGCC CCTCCGTGCC GCGTGGGGCC 780 GCGCTCGCCG GCCCCCCCCT GCCGGGTGGG CTCCCGCCGC GCGCCGGCCT GCCGGCCCCT 840 CGTGGGTCCT GCTGGCCGGG TCCGGGTCCC GGGGGTGGGG CGCGBGTCGG CGGCCGBGGG 900 TCCCCTCCBC BTCTGCTCTG BCCTGCTGGB CTCTGGBTCT GBBGBTBCGC CBTGTBGGGG 960 CGGGBGTGGG GCCTGCTCTC CCGGCCTCCG BTGBTCTCCC CTGCCTCBGC CCCBGTGGGT 1020 BGGBGBBBGG CCBGCBGBBG CBGGBGTGGC TGCBTCTTTC CTGGTGGGGC CTGCTCTCCC 1080 GGCCTCCGTG TGTTGCTGGG TGTTTTCCCG TCTCTGGTCT GCCTTCGGGG GTCGTCCGGG 1140 GCTGCBGCBB CCTCBTCBGC TCTTGCCTGG BGTGGCTCBG CCTGGGCCTG CBGGGCCBCC 1200 BGGBGBBTGG CBGCBBGGBT GGCGBGGGTC CTCBTGGCTG GGGTCBCBGB TCCTCTBGCT 1260 BGGCBGGGTG BCCBGBGBGG GCGGGTCCTC BTGGCTGGGG GCCTGGGCCT GCBGGGCCGC 1320 TCTTGCCTGG BGTGGCTCGC CCBGBGTCTT CCCTGGTCGC TGCBBTCTGC TCCGGGGCTG 1380 CBGCBBCCTC BTCBGCTCTT GCCTGGBGTG GCTCBGCCTG GGCCTGCBGG GCCBCCBGGB 1440 GBBTGGCBGC BBGGBTGGCG BGGGTCCTCB TGGCTGGGGT CBCCTGGBGG BGGGBGBGCB 1500 GGGGGTCCTC BTGGCTGGGG TCCCTCTCTC CCGTCCTCGG TTTCCTTTGC GGTCTTGGCC 1560 CGGGCTCCGG GTGCCCGCCC GCCCGCCGGC CGCCGCCCCG CCGGGCTGTC CCCGCCCCGC 1620 CCCGGCCCGG GGCGCGGGGG CGGCCCTCCC GCCCCTCTGG GCCGGCGCGG GCGTCGGCCG 1680 CTCGCGCCTG GGGTTCCCTC TCCTCCCCCT GTGCGCCTGC CTCTTGCTCT TCTGCGTCCG 1740 CTGCCTTCTC CCCTCTCCTC GGCCGTTGCC TGTGCTGTCC GTCCTGTCGC CCTTCCGTGG 1800 TGCTGTTGTC TCTTCTGCCC TCGGTGTGCT GGTGCTGGTG GTGGTGCCTC TGCCCGTGCT 1860 CGCCCTGCCT GGGCTGGCCT CTTCGGGTGT GGCTTTGGGG CTCTCTTGGT TGCCCTTTCT 1920 TCTCGTGGTG CCTCTCCTCC CTGGCTTGGT CGTTGTCTGG GGTGGTGCTC CTCTCCCTTT 1980 CCCTGCTGGC CGTTTGTCCT GTTTTCTGTC TTCCTCTTTC CTCCTGTTTC TCCGTTTGGC 2040 TTGCTGCTTG CGGGGCTGTC TCCCTTGCCC CTGTGGGCTT TCCCTGGTCC GGTCTTCTCC 2100 TTGGGGGTCG CCCTTCTTGG TGGGCTGGCT CGTCTGTCTT TTTCCTTCCT GGGGGTGGCC 2160 GTTGTGGGCG GTGTGGTCCG CCTTGCCTCT GCTGGTCTTT CCTCGGTBGB CGCGCTCGBB 2220 CTCGGGTGGG CCGGTGGTGB GCGGCGGCGB CBCGCGGBBG GCCCTGCGCG CCGBGBTCBC 2280 CTGCBGGGBG BBGTBGGCTT GCBGCBGGBC TCCCBGGBGG GTGBCBGCBG CCBGTBGBGC 2340 TBCCTCGTCC TTCBTGGTBC CGTCGGTGTG GTGGCBCGGG CTGTGTGTGB BGGCGBGCTG 2400 GGCCCCGTCT GCTGCTCCTC GTGCCGCCTC GTCCTTCATG GTACCGTCGG TGTGGTGGCC 2460 TCGGGTGGGC CGGTGGTGGG GCGCGCGCGC TCGCGTGGCT CCGGCTCTTC TTTCCCGGCT 2520 CCGTCGGCCC GGGGGCCTTG GTCTCCCTCG TCCTTCBTGG TBCCGBCCGG CGGBGCCGCC 2580 BGGGTGGBCT GGGBGTGGGT TTCTCCCCGC CGTTCTCBCC CBCCGCGCTG BGCTCBGCGC 2640 CTBBGBCTGC TGTTTCTGGB GCTCCTTGGC BBGCCBCBBB CBGCBGBGBG BBBBTCBTGB 2700 GCBBBTBBTC CBTTCTGBBB BBBBGGGBTC BBBBBCCTCC CGTTCCCCGT TCGCCTGGCG 2760 CGCGCTGCGG GTTCCTCGTG GGTTTCTCCC CGCCGTTCTC CGGTCTGTTG CCTTTGTGGG 2820 CTTCTTGTCT TTTTGGCTGT TCTTTTCCTG CTTGGCGTCT TTTCCTTTCT TTGTGCTCGG 2880 TTGTGGGTCC GCTGGTCCTT TGCCCTGTGT GTTTCTGCTG CCCGTTCGCC TGGCGCGCGC 2940 TGCGGGTTCC TCGTGGGTTT CTCCCCGCCG TTCTCCGGTC TGTTGCCTTT GTGGGCTTCT 3000 TGTCTTTTTG GCTGTTCTTT TCCTGCTTGG CGTCTTTTCC TTTCTTTGTG CTCGGTTGTG 3060 GGTCCGCTGG TCCTTTGCCC TGTGTGTTTC TGCTGGGBGC TGBTBCTGCB GATTTCBGBG 3120 GGBBGBBCCC TGBTBCTCBC CBGCTTCBGC TCTGGBGCBC BBGBGBBBGB GCBGCBGGGG 3180 GBGBGGBBGB BGCBGCBTCT TCCCBGBGBG GCTGCCTGBG CBBBTGCTGG TTTTCCTTTC 3240 CBGTCTTGGG TTTTBTBBCT CCCBGBBGGC BBGBGBGGGG CBBGGCGTTT TCTTCTCTCG 3300 CTGGTTTTCC TTTCCTGGCA GTGGGTGGGG GTGGGGGTGG GGTGGCTTCC TTGTTCCTGG 3360 GGGTGTCCTC TTGCTCTGGG CTTTTCTCCC CTTTTCCTTC CTGTCTGTTT TCCTGGGGCT 3420 CTCCTCTGTC TCTGTGTCCT TGCCCTGGCC CTCTTCCCTC TCCTGTCTCC TGTCCCTGTG 3480 TTCCGCCCGT CTTCCCTCTC CTGACCTCCT TTTCCTCCGC TGGGTGGGGC CCTGCCTGTT 3540 CTCTGCTCCC TGGCTTGGGG TTTCTTCTGT GTGTCTTCTT CCTCTGTTGG CTGGCTTTCT 3600 CCTTCTTTTG TCTTCCTGGG TGCCCCTTCT TCCTTTCTTG GGTCCTTGGT GCTTGGGCTG 3660 GGGCGTCTTG GGGTGCBGGG CCCBTCCTGC TGCGCCTGGG CGCTGCTGTG CGTCCGTCTG 3720 CTGGGGGGCC GGGGTGGCTG GGCCCTGCTT GCCGCACGAC CCCGGGCCGA CCCGAGGCTC 3780 GGGGGGCTGT GTTCTGGCGC TGGTGGGCTT GGGCCCCTCT GGGGGCTGGG TTTCCTGCTG 3840 CGCCTGGGCG CTGGCGTCTT GGGGTGCGGG GCCGGGGGGC CGGGGGGCCG CTGTTCGTGG 3900 GCCTGGGGGT GCCTGTGGCT GCCGGTTGCC CCGGTTGGTG GCGCCGTCCT GCTGCCGGTC 3960 GTTGGCTGGG TCCCCCCGCC CGTTTCCTGG GGTCCGCGTG GGGTGCTCCG GTTCCTCGTG 4020 CCGCTGCTGC CTTGTCTTTC CGGCCGTGGC GGCGTGGTGG TCCGCCCCCC CTGGCCTTCT 4080 GCTCGGGGTC TGGCTGGTTG CCGGTGCCCT TGGCGGCGGT CTTCTTCCTG GTGGCTCTGG 4140 GCCCGGCCGG TCTCGGGCGT CTCGTGTTCG CTCTTGTGCT GTTCCGGCCG CTCCTTCCTC 4200 EPI-109 569

TTCCGCCGCC GCCGCTCCCC GCCCGCTCGT CGCCCTGGCC CGGCCTCCTC CTGGCCGCTG 4260 TCTCGGGCGG CGGCCTTGGC GCTCCGTTTG GGGCTGCCTC TGGCGCTTCC GGCCCTCGGC 4320 CTGGGCGCTC TCTTCCGCCT GTGCTGGTGG CCCTCGTGGG CCCCTCCTGG CCTCCGGTGT 4380 CCTGTGGTCC CCCGGCTGGT GGCCGGGCCG GTTGGGCGGG CGTGGGCGCC GGCGGGTCCT 4440 CCGGGCTGCC CTTCTCCGCC GGGGGTCCCG CGCTCCTGCT GTTCCCTGGG CTCTTCTGCC 4500 TCTCTCCTGG GTGGGTGCTG GGTGCCGGGG TCTCCGGGCT TGCCCCGCGC TGCTGGGCGT 4560 TCTGCGGTCT TGGGGTTGTC TGTGGCCCCG CTCGTGTCGC CCTCCGTCGC CCGTCGCCGG 4620 CCTCGTCCCC TCCTGGGTGC GCGGCGGGCT GGTCCTGGCG TTTTGCTCCT TCCTGGGCGT 4680 CTTGGGGTGC BGGGCCCBTC CTGCTGCGCC TGGGCGCTGC TGTGCGTCCG TCTGCTGGGG 4740 GGCCGGGGTG GCTGGGCCCT GCTTGCCGCA CGACCCCGGG CCGACCCGAG GCTCGGGGGG 4800 CTGTGTTCTG GCGCTGGTGG GCTTGGGCCC CTCTGGGGGC TGGGTTTCCT GCTGCGCCTG 4860 GGCGCTGGCG TCTTGGGGTG CGGGGCCGGG GGGCCGGGGG GCCGCTGTTC GTGGGCCTGG 4920 GGGTGCCTGT GGCTGCCGGT TGCCCCGGTT GGTGGCGCCG TCCTGCTGCC GGTCGTTGGC 4980 TGGGTCCCCC CGCCCGTTTC CTGGGGTCCG CGTGGGGTGC TCCGGTTCCT CGTGCCGCTG 5040 CTGCCTTGTC TTTCCGGCCG TGGCGGCGTG GTGGTCCGCC CCCCCTGGCC TTCTGCTCGG 5100 GGTCTGGCTG GTTGCCGGTG CCCTTGGCGG CGGTCTTCTT CCTGGTGGCT CTGGGCCCGG 5160 CCGGTCTCGG GCGTCTCGTG TTCGCTCTTG TGCTGTTCCG GCCGCTCCTT CCTCTTCCGC 5220 CGCCGCCGCT CCCCGCCCGC TCGTCGCCCT GGCCCGGCCT CCTCCTGGCC GCTGTCTCGG 5280 GCGGCGGCCT TGGCGCTCCG TTTGGGGCTG CCTCTGGCGC TTCCGGCCCT CGGCCTGGGC 5340 GCTCTCTTCC GCCTGTGCTG GTGGCCCTCG TGGGCCCCTC CTGGCCTCCG GTGTCCTGTG 5400 GTCCCCCGGC TGGTGGCCGG GCCGGTTGGG CGGGCGTGGG CGCCGGCGGG TCCTCCGGGC 5460 TGCCCTTCTC CGCCGGGGGT CCCGCGCTCC TGCTGTTCCC TGGGCTCTTC TGCCTCTCTC 5520 CTGGGTGGGT GCTGGGTGCC GGGGTCTCCG GGCTTGCCCC GCGCTGCTGG GCGTTCTGCG 5580 GTCTTGGGGT TGTCTGTGGC CCCGCTCGTG TCGCCCTCCG TCGCCCGTCG CCGGCCTCGT 5640 CCCCTCCTGG GTGCGCGGCG GGCTGGTCCT GGCGTTTTGC TCCTTCCTGG CTGCCCCBGT 5700 TTTTGBTCCT CBCBTGCCGT GGGGBGGBCB BTGGCTGCCT CCCCGGGGTT TCTGCTGCTT 5760 GCTGCTTCTT TCCCGTCTCC CTTCTTTCCC GTCTCCTTTT TGCCTCTTTG GGTTCCTGTT 5820 GTTTCTGGCC TGCTTGGTGG CGGCTTGTGC GTTTCCTCTC TCTTCTCTTG GGTCTCCGCT 5880 TCTCGTCCTG CCTTTTCCTG TCTCTGTCGC GCCGTTCCTC CTCCGGCGTC CTCCTGCCCT 5940 GTGCTGTTTG CCTCGGGTGG TGCGGGTCCC GGTGCTCCCC CGGCGGGCCG GCTGGTTGCC 6000 TGGGCCTGTC TGGTGGGGTG TGGGGCCGCT GGGTTGGGGG TGTGGTGGGC TCTTCTGTGG 6060 CCTGTGGGGC TGTTGGTGTC TCTGTGGGCG TGTGCTGGGT CTTGGGGCTT CCTCCCTTGT 6120 GCTGGGTGCG GCCTCCCCGC CCCCCTTCTG GGCCGGTGGC CTGGCTCCTT GTGGGCGCTT 6180 CTGGCTCTTG CCCTGTCCTT CTTCGCCTCG TGGCTGCTGG GCTGC 6225

(2) INFORMATION FOR SEQ ID NO: 2411 (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 7033 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2411: CCTCCTTCCT GGTCTGTCTG CCBGBCBBBT TTGGGBBGTG BBCBGTTTTG GBBCCBTGTT 60 TCCCBGTCTC TGBGCTGTGG CGCCCTGCTG CTCTTTCTGC TTCCCTTGGT GGGTTGGGCC 120 GCTGGTTGTT CTGGGGTTCT TGCTGCCCCT TCTGTCCCTG TTTGCTGGTG TCTGCGCCCC 180 CBBCBGBBGB BGCBGBCBBB TTTGGGBBGT GBBCBGTTTT GGBBCCBTGT TTCCTGTGCG 240 CTCGGCCTGG TCCCGGGGGT CTCCTCTTGT TGTTGCTTGC GCCTCCTGCT GGGGGTCCCT 300 CTGTTCTTGT TTTGGGGGCG GGCCCGGCCG TTGTCTTGGT TTGGGGGTTT CCGTTGGGGT 360 TCTCCTGGCC CGGGCCTTGC CCGGCCGTGG TCCCGGCTTC GTTCCTGTCT CCGTCTCGGC 420 TCTTCTGGGG CCTTGCGCTG TCTTTGGTGG CBCCGTCCBG TGBTGGTGCG GTBCTTGTCG 480 CTGCBGCGCT CGGCCTGGTC CCGGBGBGCG CGCGGGCCGG GGGCTGCTGG GGGTTGGCCC 540 GGGGTGCCCC GCCGCTGGGT GCCCTCGTCC TCTGCGGTCG TGTCTCCTGG CTCTGGTTCC 600 CCGCTGCGCC CGTTGTCCTC TGGGGTGGCC TTCGCTCCCG GGTCTGGTTC TTGTGTTGGG 660 GGTCCCTTTT TGGGCCTGTT GTGGCGTGGC TTGTGTGTTC GGTTTCTGCC CTGTCCTCCG 720 GCGTCCCCGG BGCCTCCCCG GGGCBGGBTG BCTTTTGBGG GGGBCBCBGB TGTCTGGGCB 780 TTGCCBGGTC CTGGGBBCBG BGCCCCGBGC BGGBCCBGGB GTGCGGGCBG CGCGGGCCGG 840 GGGCTGCTGG GBGCCBTBGC GBGGCTGBGC CTCTTTTCTG TTTTTCCCCT CTGCCTTTGT 900 TTGGGTTCGC TTCCTTTCTG CTTCTTCCCT GTGTCTCCTG TCTCCGCTTT TTTCTTCGTC 960 TTTGTTGTTT TCTCTTCCTT GCTGBGCBBG BTBTCTBGBT TCTGGGGTGG TCTCGBTTTT 1020 BBBBGCTTGB GBBGCTGCBB BCBTTBTCCB BBGTBTBTTT GBGGCTCCBB GGBTCBCGBC 1080 CBTCTTCCCB GGCBTTTTBB GTTGCTGTCG TBBGTGBGBG CTGBGBGBBB CTGTGBBGCB 1140 BTCBTGBCTT CBBGBGTTCT TTTCBCCCGT TCTTGGCTTC TTCTGTCCGT TGGCTTCTCG 1200 TTGTCCCTGT GGGCTTCTCG TTGTCCCCCC TTCGGGGGCT GGTGGGGCCG TCCTTGCCTG 1260 CTGGGTTCTT GGCTTCTTCT GTCCGTTGGC TTCTCGTTGT CCCTGTGGGC TTCTCGTTGT 1320 CCCCCCTTCG GGGGCTGGTG GGGCCGTCCT TGCCTGCTGG TTTTCTCTTT CGCTTTCTTT 1380 TCGTCTCCTG TTCCTCCTTT TTTGCTGTTT TTTCTCCTTC TTCTCTCCTT TCTTTTCTTT 1440 TCTCTTTCGC TTTCTTTTCG TCTCCTGTTC CTCCTTTTTT GCTGTTTTTT CTCCTTCTTC 1500 TCTCCTTTCT TTTCCTCTGT CTTGTTCTGG TCCTTCGTGG GGCTCTGTGT CGCGTGGGTG 1560 CGGCCGTGGC CGGCGGBCCB GGBGTTGGBG CBGGBGCBGG BCGGGCBGGC GGCTCBTGTT 1620 TGGBTCGGCB GGBGGCBCTC CTCTGGTTGG CTTCCTTCGC CGGCBCBTGC TBGCBGGBBG 1680 BBCBGBGGGG GBBGCBGTTG GGBGGTGBGB CCCBTTBBTB GGTGTCGBTC CCTGTTTCCC 1740 CCCTTTCGTT CTGCGTTTGC CTTTGGCGTT TTTTGTTTGT TTTCTCTCTC CGTCTTTCTT 1800 CTCCCCTGTG GGBBTTTCTG TGGGGBTGGC BTBCBCGTBG GCBGCTCCBB GBGCTBGCBB 1860 BCTCBBBTGC BGBBGCBTCC TCBTGGCTCT GBBBCGGTGG GAATTTCTGT GGGGBTGGCA 1920 TACACGTAGG CAGCTCCAAG AGCTAGCAAA CTCAAATGCA GAAGCATCCT CATGGCTCTG 1980 EPI-109 570

AAACGGGGGG TGGCTTCCTG CCGCGTCTCT GGGCCGTCCC GTCCCTCGGC CCCGCGCCGC 2040

GCTCGGCTCC TCTCCCTCTG GCCCGGCTCG GGGCGGGGCG GGGCGGTGGG CGGGCGGCGC 2100

TGCCCTGCGC GCGGCGCTGG CCCCTGCTGG CCGTCGGCTG CGCGCTGCTG GCTGCCCTGC 2160

TGGCCGCGCC GGGGCCTGTC CGCCTCTGCG GGCGCTGTCT CCTGGCTTGT CTTCCGGCTC 2220

TTCTGCTGGG GTGGGGCTGG GCGGCCGGCC CGGTGCTGGG GCTCCTCGGG GGGGGGGGCT 2280

CTTCCGGGCT GTCTCCCTCC GGGGCGGGGG TTTCTGGCCG TGGGGGTCTT GCCTGGCCTC 2340

CGGGCTCCTG CTTGTCTTGC CTTCCTTCTC TGGTCGGTTG TGGCTCGGGG CTCCGTGGGT 2400

CCCTGGCGCC CGTTTGTGTT TTGTCTTTTC CCCTGGCGTC CCTGTGCCCC TCTCCTCTCC 2460

TTCCTCTGCT TCTCGCTCTC CTTTGTGGGG CCCTCCCTGC TGCTCTTGGT TTTGGGCTTT 2520

TTTTCTCTTC CTCCTTTTTC GTGCGTGGGC CTCCGCACGC CTCTTGCCAC CTCCTGCGCA 2580

GGGCAGCGCC TTGGGGCCAG CGCCGCTCCC GGCGCGGCCA GCAGGGCAGC CAGCAGCGCG 2640

CAGCCGACGG CCAGCATGCT TCCTCCTCGG CTACCACTCC ATGGTCCCGC AGAGGCGGAC 2700

AGGCGCBCGC CTCTTGCCBC CTCCTGCGCB GGGCBGCGCC TTGGGGCCBG CGCCGCTCCC 2760

GGCGCGGCCB GCBGGGCBGC CBGCBGCGCG CBGCCGBCGG CCBGCBTGCT TCCTCCTCGG 2820

CTBCCBCTCC BTGGTCCCGC BGBGGCGGBC BGGCGGGGTG GBBBGGTTTG GBGTBTGTCT 2880

TTBTGCBCTG BCBTCTBBGT TCTTTBGCBC TCCTTGGCBB BBCTGCBCCT TCBCBCBGBG 2940

CTGCBGBBBT CBGGBBGGCT GCCBBGBGBG CCBCGGCCBG CTTGGBBGTC BTGTTTBCBC 3000

BCBGTGBGBT GGTTCCTTCC GGGCTTGTGT GCTCTGCTGT CTCTTGGTTC CTTCCGGTGG 3060

TTTCTTCCTG GCTCTTGTCC TTTCTCTTGG CCCTTGGCCG GGBGTGGGGG TCCTGGBCGG 3120

CBCTGBBGGC BTCCBGGGCT CCCTTCCBGT CCTTCTTGTC CGCTGCCBGC BCCCCTTCBT 3180

TCCBGBGGCT GBTGGCCTCC BCCBGGGBCB TGBTTBGGTB GBBBCTBGGB GGCCGGCCTC 3240

CBCCBGGGBC BTGGTCCTTC TTGTCCGCTG CCTCTCTGGG GTTTTCGGTC TGGGTGGGCT 3300

TTCCTCCTGG GGCTGCTGCT GGGCTCTTCT TTTTGTTTCT GGCCTGGTGC TCTCTCGTGC 3360

CCTTTCCCTT GGGTGTCTTG TTTTTGTGGC CTCCBCCBGG GBCBTGGTCT TTGTTTCTGG 3420

GCTCGTGCCC CBTCCCGGCT TCTCTCTGGT TCCGTCCTCT GTGGTGTTTG GCCCTGCTTC 3480

CTTTTGCCTG TTGAGGGGGC AGCAGTTGGG CCCCAAAGGC CCTCTCGTTC ACCTTCTGGC 3540

ACGGAGTTGC ATCCCCATAG TCAAACTCTG TGGTCGTGTC ATAGTCCTCT GTGGTGTTTG 3600

GAGTTTCCAT CCCGGCTTCT CTCTGGTTCC AAGGGAGBGG GGGCBGCBGT TGGGCCCCBB 3660

BGGCCCTCTC GTTCBCCTTC TGGCBCGGBG TTGCBTCCCC BTBGTCBBBC TCTGTGGTCG 3720

TGTCBTBGTC CTCTGTGGTG TTTGGBGTTT CCBTCCCGGC TTCTCTCTGG TTCCBBGGGB 3780

GGGCBCGGGG CBGTGGGCGG GCBBTGTBGG CBBBGCBGCB GGGTGTGGTG TCCGBGGBBT 3840

BTGGGGBGGC BGBTGCBGGB GCGCBGBGGG CBGTBGCBBT GBGGBTGBCB GCGBGGCGTG 3900

CCGCGGBGBC CTTCBTGGTB CCTGTGGBGB GGCTGTCGGB GGGGGTGTGG TGTCCGCTTG 3960

GCGGTTCTTT CGGGTGTTTC TTCTCTGGGT TGGCCTGCTG CTCGTCGTGG TCGCTCCGCT 4020

CCCGGGTTCG TCTCGCTCTG TCGCCCCTTC CTTCCTTGTC GTGTTCCTCC CTTCCTTGCC 4080

TCTGBTGTTT GTTBCCBBBG CBTCBBGBBT BGCTTTGCTB TCTBBGGBTC BCBTTTBGBC 4140

BTBGGBBBBC GCTGTBGGTC BGBBBGBTGT GCTTBCCTTC BCBCBGBGCT GCBGBBBTCB 4200

GGBBGGCTGC CBBGBGBGCC BCGGCCBGCT TGGBGTCBTG TTTBCBCBCB GTGBGGTGCT 4260

CCGGTGGCTT TTTGCTTGTG TGCTCTGCTG TCTCTGTTCC TTCCGGTGGT TTCTTCCTGG 4320

CTCTTGTCCT TTCTCTTGGC CCTTGGCCCC TTGBGCBGGB BGCTCTGGGG CBGGGBGCTG 4380

GCBGGGCCCB GGGGGGTGGC TTCCTGCBCT GTCCBGBGTG CBCTGTGCCB CBGCBGCBGC 4440

TGCBGGGCCB TCBGCTTCBT GGGGCTCTGG GTGGCBGGTC CBGCCBTGGG TCTGGGTGGG 4500

GCTGGGCTGC BGGCTCCGGG CGGTCCBGCC BTGGGTCTGG GGGCTGGGCT GCBGGCTCCG 4560

GGCGGGCGGG TGCGGGCTGC GTGCTGGGGG CTGCCCCGCA GGCCCTGCGG TCCBGCCBTG 4620

GGTCTGGGGG CTGGGCTGCB GGCTCCGGGC GGGCGGGTGC GGGCTGCGTG CTGGGGGCTG 4680

CCCCGCAGGC CCTGCGCBCC GCCTGGBGCC CTGGGGCCCC CCTGTCTTCT TGGGGBGCGC 4740

CTCCTCGGCC BGCTCCBCGT CCCGGBTCBT GCTTTCBGTG CTCBTGGTGT CCTTTCCBGG 4800

GGBGBGBGGG GCTGGTCCTC TGCTGTCCTT GCTGGTGCTC BTGGTGTCCT TTCCGCCCTG 4860

GGGCCCCCCT GTCTTCTTGG GGCCTCTTCC CTCTGGGGGC CGTCTCTCTC CCTCTCTTGC 4920

GTCTCTCTCT TTCTCTCTCT CTCTTCCCCT TTCCCGCTCT TTCTGTCTCG GTGTCTGGTT 4980

TTCTCTCTCC GCTGGCTGCC TGTCTGGCCT GCGCTCTTGG CCTGTGCTGT TCCTCCTCCG 5040

GTTCCTGTCC TCTCTGTCTG TCGCCCCCTC TGGGGTCTCC CTCTGGGTGG TGGTCTTGTT 5100

GCTTGGGCTG GGCTCCGTGT CTCCBGTGCT CBTGGTGTCC GCTGBGGGBG CGTCTGCTGG 5160

CGCTGGTCCT CTGCTGTCCT TGCTGGTGCT CBTGGTGTCC TTTCCGCCCT GGGGCCCCCC 5220

TGTCTTCTTG GGGCCTCTTC CCTCTGGGGG CCGTCTCTCT CCCTCTCTTG CGTCTCTCTC 5280

TTTCTCTCTC TCTCTTCCCC TTTCCCGCTC TTTCTGTCTC GGTGTCTGGT TTTCTCTCTC 5340

CGCTGGCTGC CTGTCTGGCC TGCGCTCTTG GCCTGTGCTG TTCCTCCTCC GGTTCCTGTC 5400

CTCTCTGTCT GTCGCCCCCT CTGGGGTCTC CCTCTGGCGT GGTGGTCTTG TTGCTTGGGC 5460

TGGGCTCCGT GTCTCCBGTG CTCBTGGTGT CCGCTGBGGG BGCGTCTGCT GGCCTGCTGB 5520

GGCTTGGGTC TCCGGGCGBT TCTCTGCBGB BGBTGCTCBB BGGGCTCCGG CBGTTCCTCC 5580

TTGBTCTGGT CGCTGTCGTB CCBGTCGGBC CBGTBBTTCB GBTCBTCBTT GGCTCCTBTT 5640

TCTTCTGCBB BCBGCTGBGT GGBGBCBBGB BBBBBGBCTG CCBBGGCCBC GBGGBTTTTC 5700

BTGTTGGBTT TTGCGBCGGB CBGTCCCGCG GGGTGCTGAG TTTCTCTGGT TCCTCCGBGC 5760

GCBCGTGGTC GCTCCGCGTT TCTCTGGTTC CTCCGGTCCC GCGGGGTGCT GTCTGGTCGC 5820

TGTCGTGGCT TGGGTCTCCG GGCGGTTTCC TTCCTTTTCC GCCGGCCCTT CTCACTGGAG 5880

GCACCGGGCA GTCCTCCATG GGAGGGTTGG GCTTGGCCGG GGCTGCCCGG TGCCTCCTCT 5940

TGGCTGGTCC CTCGTTGTCC TTGGGCCCCG CTCCCGCTGC TCGGCCTCCG TGTTCTTTGG 6000

CCTCTTGCTC CGCCTGCTGT CTTGTCCCGT CCCCTCCTCG CTTGCGTTTC CCTCTTCCTT 6060

GTCTTCCAGG CCTTCCTCCG CTTCCGCTGC TGGGGCCCGC GCCGGGGGGG CGCTCGGCTC 6120

CGCGGCTTCC TCCCCGGCTG GGGGGTCCTG GTCTCCGGGG CCTGCGGCTC GCGGGCTCGG 6180

GGCTGCGTGC GCCGCGCGCG GCGTCCGCGG TGGGTGGCGC TGTCCCGCCG TGGTGTGTCT 6240

CCGTTCTCGT CCTGCGCCGT CCTGGTCTGC CCGTGGGGTC CTGGGCGTGG TGGGGGGCGT 6300

CTGGTGCCTC GTCTGCCCCG TGGGGCTTCG GGCTCGGGGC TGTTCGTCCC CCCTGCCGCT 6360

CTGTGGCCTC CGGGGCTCCT CGTTTTCGCT GCTTCGGGTG TCCTTCTCGG CGTGTGGCCC 6420

CGGGTCCCGG CCCTGCTGGG CTGGGCGGGG TCGCTGCCCT GGGCTTCTGG CCCGTCTGGT 6480 EPI-109 571

TGTCTGTCGG TGCTTGTCTC GGGTTTCTGG CCTCTGTGCT GGGCGCTTCT CTGCCTCCTG 6540

CTCCGCCCTC CTGGTGGCTC GGCTGGGGGT GCCCGTGCGG GGGTGGGTGT GGGGTGTTTT 6600

CGGGGTCCTC CCCTTCCCGT TTCATCTTGG CTTTATCCTC TCCCCTTGTT CCTCCCCTCT 6660

CCTGCTCTGG RGTCTCCTCT TCCCTCCCTC CCCTGCCGTG TTGTCTGTGG GTGTCGTTTC 6720

GCTCTTGTTG CCCTGGGCCC TTCCCTGCTG GGGGGGAGTT TCATCTTGGG TTTCBTCTTG 6780

GCTTTBTCCT CTCCCCTTGT TCCTCCCCTC TCCTGCTCTG GRGTCTCCTC TTCCCTCCCT 6840

CCCCTGCCGT GTTGTCTGTG GGTGTCGTTT CGCTCTTGTT GCCCTGGGCC CTTCCCTGCT 6900

GGGGGGGBGT TTCBTCTTGG GGGGGBGTTT CBTCTTGGCT TTCCGTGTTG TCBGTGGTGC 6960

TGCCCGTTTG BGGTBTGGCG CTCCBCCBBT TCCCTTTTCT CCTTGTTTTC CGTTTCTCTT 7020

GCCGTCTGTG GTT 7033

(2) INFORMATION FOR SEQ ID NO:2412: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2412: GATGGAGGGC GGCATGGCGG G 21

(2) INFORMATION FOR SEQ ID NO:2413: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2413: GCGGGTCGCC GG 12

(2) INFORMATION FOR SEQ ID NO:2414: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2414: GGCGGGCBCB GGC 13

(2) INFORMATION FOR SEQ ID NO:2415: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(x ) SEQUENCE DESCRIPTION: SEQ ID NO: 2415: GGCGGGCBC 9

(2) INFORMATION FOR SEQ ID NO:2416: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2416: GCGGCCTGG 9

(2) INFORMATION FOR SEQ ID NO:2417: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2417: GGBGGGCGGC 10

(2) INFORMATION FOR SEQ ID NO:2418: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2418: GBTGGBGGG 9

(2) INFORMATION FOR SEQ ID NO:2419: EPI-109 572

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2419: GGCTGGGC 8

(2) INFORMATION FOR SEQ ID NO:2420: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 961 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2420:

1 ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC

61 CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG

121 CGGGATGCCA CCTTCTGCTT CATCGTCTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC

181 CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC

241 CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA

301 ATTGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC

361 CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG

421 ACCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC

481 AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG

541 GTCTACTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC

601 CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC

661 GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC

721 TTCCTCTTTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC

781 CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC

841 TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT

901 AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA

961 GAAGAGAGGC CTGATGACTA G

(2) INFORMATION FOR SEQ ID NO:2421: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2881 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2421: 1 ATGAGTGTCA GAAGTGTGAA GGGTGCCTGT TCTGAATCCC AGAGCCTCCT CTCCCTCTGT

61 GAGGCTGGCA GGTGAGGAAG GGTTTAACCT CACTGGAAGG AATCCCTGGA GCTAGCGGCT 121 GCTGAAGGCG TCGAGGTGTG GGGGCACTTG GACAGAACAG TCAGGCAGCC GGGAGCTCTG 181 CCAGCTTTGG TGACCTTGGG CCGGGCTGGG AGCGCTGCGG CGGGAGCCGG AGGACTATGA 241 GCTGCCGCGC GTTGTCCAGA GCCCAGCCCA GCCCTACGCG CGCGGCCCGG AGCTCTGTTC 301 CCTGGAACTT TGGGCACTGC CTCTGGGACC CCTGCCGGCC AGCAGGCAGG ATGGTGCTTG

361 CCTCGTGCCC CTTGGTGCCC GTCTGCTGAT GTGCCCAGCC TGTGCCCGCC ATGCCGCCCT 421 CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG

481 TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA 541 CCTTCTGCTT CATCGTGTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC 601 CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG 661 CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG 721 ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG 781 CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT 841 TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG 901 AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA 961 ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT

1021 TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA 1081 AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCCTCTTTG 1141 CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC 1201 ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA 1261 ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA 1321 ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC 1381 CTGATGACTA GACCCCGCCT TCCGCTCCCA CCAGCCCACA TCCAGTGGGG TCTCAGTCCA 1441 GTCCTCACAT GCCCGCTGTC CCAGGGGTCT CCCTGAGCCT GCCCCAGCTG GGCTGTTGGC 1501 TGGGGGCATG GGGGAGGCTC TGAAGAGATA CCCACAGAGT GTGGTCCCTC CACTAGGAGT 1561 TAACTACCCT ACACCTCTGG GCCCTGCAGG AGGCCTGGGA GGGCAAGGGT CCTACGGAGG 1621 GACCAGGTGT CTAGAGGCAA CAGTGTTCTG AGCCCCCACC TGCCTGACCA TCCCATGAGC 1681 AGTCCAGCGC TTCAGGGCTG GGCAGGTCCT GGGGAGGCTG AGACTGCAGA GGAGCCACCT 1741 GGGCTGGGAG AAGGTGCTTG GGCTTCTGCG GTGAGGCAGG GGAGTCTGCT TGTCTTAGAT EPI-109 573

1801 GTTGGTGGTG CAGCCCCAGG ACCAAGCTTA AGGAGAGGAG AGCATCTGCT CTGAGACGGA 1861 TGGAAGGAGA GAGGTTGAGG ATGCACTGGC CTGTTCTGTA GGAGAGACTG GCCAGAGGCA

1921 GCTAAGGGGC AGGAATCAAG GAGCCTCCGT TCCCACCTCT GAGGACTCTG GACCCCAGGC

1981 CATACCAGGT GCTAGGGTGC CTGCTCTCCT TGCCCTGGGC CAGCCCAGGA TTGTACGTGG

2041 GAGAGGCAGA AAGGGTAGGT TCAGTAATCA TTTCTGATGA TTTGCTGGAG TGCTGGCTCC

2101 ACGCCCTGGG GAGTGAGCTT GGTGCGGTAG GTGCTGGCCT CAAACAGCCA CGAGGTGGTA

2161 GCTCTGAGCC CTCCTTCTTG CCCTGAGCTT TCCGGGGAGG AGCCTGGAGT GTAATTACCT

2221 GTCATCTGGG CCACCAGCTC CACTGGCCCC CGTTGCCGGG CCTGGACTGT CCTAGGTGAC

2281 CCCATCTCTG CTGCTTCTGG GCCTGATGGA GAGGAGAACA CTAGACATGC CAACTCGGGA

2341 GCATTCTGCC TGCCTGGGAA CGGGGTGGAC GAGGGAGTGT CTGTAAGGAC TCAGTGTTGA

2401 CTGTAGGCGC CCCTGGGGTG GGTTTAGCAG GCTGCAGCAG GCAGAGGAGG AGTACCCCCC

2461 TGAGAGCATG TGGGGGAAGG CCTTGCTGTC ATGTGAATCC CTCAATACCC CTAGTATCTG

2521 GCTGGGTTTT CAGGGGCTTT GGAAGCTCTG TTGCAGGTGT CCGGGGGTCT AGGACTTTAG

2581 GGATCTGGGA TCTGGGGAAG GACCAACCCA TGCCCTGCCA AGCCTGGAGC CCCTGTGTTG

2641 GGGGGCAAGG TGGGGGAGCC TGGAGCCCCT GTGTGGGAGG GCGAGGCGGG GGAGCCTGGA

2701 GCCCCTGTGT GGGAGGGCGA GGCGGGGGAT CCTGGAGCCC CTGTGTCGGG GGGCGAGGGA

2761 GGGGAGGTGG CCGTCGGTTG ACCTTCTGAA CATGAGTGTC AACTCCAGGA CTTGCTTCCA

2821 AGCCCTTCCC TCTGTTGGAA ATTGGGTGTG CCCTGGCTCC CAAGGGAGGC CCATGTGACT 2881 AATAAAAAAC TGTGAACCCT

(2) INFORMATION FOR SEQ ID NO: 2422: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1921 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2422: 1 CGCATTTGTG TTTTAATAAA AGAATCTGGA AGATAAATAG TCTTGAAGAG AGACAAAGGA

61 AGGAAAATTT AAATCCTTAG ATTCAAGCAG AAGAATTCCA TGTGGAAGGT TTGGGTTGTT 121 GTTGTTGTTG TTTGGTGTGT TTTTTGTTTT TTTGTTTTTT TGTTTTTTTT TGAGATGGAG 181 TCTCGCTGTG TTACCGGGAG CGACAGAGCC GCACGGCCGA GTCGAGTCCC AGCCAGCTAC 241 CATCCCTCTG GAGCTTACCG GCCGGCCTTG GCTTCCCCAG GAATCCCTGG AGCTAGCGGC 301 TGCTGAAGGC GTCGAGGTGT GGGGGCACTT GGACAGAACA GTCAGGCAGC CGGGAGCTCT

361 GCCAGCTTTG GTGACCTTGG GTGCTTGCCT CGTGCCCCTT GGTGCCCGTC TGCTGATGTG

421 CCCAGCCTGT GCCCGCCATG CCGCCCTCCA TCTCAGCTTT CCAGGCCGCC TACATCGGCA 481 TCGAGGTGCT CATCGCCCTG GTCTCTGTGC CCGGGAACGT GCTGGTGATC TGGGCGGTGA 541 AGGTGAACCA GGCGCTGCGG GATGCCACCT TCTGCTTCAT CGTGTCGCTG GCGGTGGCTG 601 ATGTGGCCGT GGGTGCCCTG GTCATCCCCC TCGCCATCCT CATCAACATT GGGCCACAGA 661 CCTACTTCCA CACCTGCCTC ATGGTTGCCT GTCCGGTCCT CATCCTCACC CAGAGCTCCA 721 TCCTGGCCCT GCTGGCAATT GCTGTGGACC GCTACCTCCG GGTCAAGATC CCTCTCCGGT 781 ACAAGATGGT GGTGACCCCC CGGAGGGCGG CGGTGGCCAT AGCCGGCTGC TGGATCCTCT 841 CCTTCGTGGT GGGACTGACC CCTATGTTTG GCTGGAACAA TCTGAGTGCG GTGGAGCGGG 901 CCTGGGCAGC CAACGGCAGC ATGGGGGAGC CCGTGATCAA GTGCGAGTTC GAGAAGGTCA 961 TCAGCATGGA GTACATGGTC TACTTCAACT TCTTTGTGTG GGTGCTGCCC CCGCTTCTCC

1021 TCATGGTCCT CATCTACCTG GAGGTCTTCT ACCTAATCCG CAAGCAGCTC AACAAGAAGG

1081 TGTCGGCCTC CTCCGGCGAC CCGCAGAAGT ACTATGGGAA GGAGCTGAAG ATCGCCAAGT

1141 CGCTGGCCCT CATCCTCTTC CTCTTTGCCC TCAGCTGGCT GCCTTTGCAC ATCCTCAACT

1201 GCATCACCCT CTTCTGCCCG TCCTGCCACA AGCCCAGCAT CCTTACCTAC ATTGCCATCT

1261 TCCTCACGCA CGGCAACTCG GCCATGAACC CCATTGTCTA TGCCTTCCGC ATCCAGAAGT

1321 TCCGCGTCAC CTTCCTTAAG ATTTGGAATG ACCATTTCCG CTGCCAGCCT GCACCTCCCA

1381 TTGACGAGGA TCTCCCAGAA GAGAGGCCTG ATGACTAGAC CCCGCCTTCC GCTCCCACCG

1441 CCCACATCCA GTGGGGTCTC AGTCCAGTCC TCACATGCCC GCTGTCCCAG GGGTCTCCCT

1501 GAGCCTGCCC CAGCTGGGCT GTTGGCTGGG GGCATGGGGG AGGCTCTGAA GAGATACCCA

1561 CAGAGTGTGG TCCCTCCACT AGGAGTTAAC TACCCTACAC CTCTGGGCCC TGCAGGAGGC

1621 CTGGGAGGGC AAGGGTCCTA CGGAGGGACC AGGTGTCTAG AGGCAACAGT GTTCTGAGCC

1681 CCCACCTGCC TGACCATCCC ATGAGCAGTC CAGAGCTTCA GGGCTGGGCA GGTCCTGGGG

1741 AGGCTGAGAC TGCAGAGGAG CCACCTGGGC TGGGAGAAGG TGCTTGGGCT TCTGCGGTGA

1801 GGCAGGGGAG TCTGCTTGTC TTAGATGTTG GTGGTGCAGC CCCAGGACCA AGCTTAAGGA

1861 GAGGAGAGCA TCTGCTCTGA GACGGATGGA AGGAGAGAGG TTGAGGATGC ACTGGCCTGT 1921 TCTGTAGGAG AGACTGGCCA GA

(2) INFORMATION FOR SEQ ID NO:2423: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 5904 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2423: ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTTCTGCTT EPI-109 574

CATCGTCTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG CCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCCTCTTTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA G ATGAGTGTCA GAAGTGTGAA GGGTGCCTGT TCTGAATCCC AGAGCCTCCT CTCCCTCTGT GAGGCTGGCA GGTGAGGAAG GGTTTAACCT CACTGGAAGG AATCCCTGGA GCTAGCGGCT GCTGAAGGCG TCGAGGTGTG GGGGCACTTG GACAGAACAG TCAGGCAGCC GGGAGCTCTG CCAGCTTTGG TGACCTTGGG CCGGGCTGGG AGCGCTGCGG CGGGAGCCGG AGGACTATGA GCTGCCGCGC GTTGTCCAGA GCCCAGCCCA GCCCTACGCG CGCGGCCCGG AGCTCTGTTC CCTGGAACTT TGGGCACTGC CTCTGGGACC CCTGCCGGCC AGCAGGCAGG ATGGTGCTTG CCTCGTGCCC CTTGGTGCCC GTCTGCTGAT GTGCCCAGCC TGTGCCCGCC ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTTCTGCTT CATCGTGTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCCTCTTTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA GACCCCGCCT TCCGCTCCCA CCAGCCCACA TCCAGTGGGG TCTCAGTCCA GTCCTCACAT GCCCGCTGTC CCAGGGGTCT CCCTGAGCCT GCCCCAGCTG GGCTGTTGGC TGGGGGCATG GGGGAGGCTC TGAAGAGATA CCCACAGAGT GTGGTCCCTC CACTAGGAGT TAACTACCCT ACACCTCTGG GCCCTGCAGG AGGCCTGGGA GGGCAAGGGT CCTACGGAGG GACCAGGTGT CTAGAGGCAA CAGTGTTCTG AGCCCCCACC TGCCTGACCA TCCCATGAGC AGTCCAGCGC TTCAGGGCTG GGCAGGTCCT GGGGAGGCTG AGACTGCAGA GGAGCCACCT GGGCTGGGAG AAGGTGCTTG GGCTTCTGCG GTGAGGCAGG GGAGTCTGCT TGTCTTAGAT GTTGGTGGTG CAGCCCCAGG ACCAAGCTTA AGGAGAGGAG AGCATCTGCT CTGAGACGGA TGGAAGGAGA GAGGTTGAGG ATGCACTGGC CTGTTCTGTA GGAGAGACTG GCCAGAGGCA GCTAAGGGGC AGGAATCAAG GAGCCTCCGT TCCCACCTCT GAGGACTCTG GACCCCAGGC CATACCAGGT GCTAGGGTGC CTGCTCTCCT TGCCCTGGGC CAGCCCAGGA TTGTACGTGG GAGAGGCAGA AAGGGTAGGT TCAGTAATCA TTTCTGATGA TTTGCTGGAG TGCTGGCTCC ACGCCCTGGG GAGTGAGCTT GGTGCGGTAG GTGCTGGCCT CAAACAGCCA CGAGGTGGTA GCTCTGAGCC CTCCTTCTTG CCCTGAGCTT TCCGGGGAGG AGCCTGGAGT GTAATTACCT GTCATCTGGG CCACCAGCTC CACTGGCCCC CGTTGCCGGG CCTGGACTGT CCTAGGTGAC CCCATCTCTG CTGCTTCTGG GCCTGATGGA GAGGAGAACA CTAGACATGC CAACTCGGGA GCATTCTGCC TGCCTGGGAA CGGGGTGGAC GAGGGAGTGT CTGTAAGGAC TCAGTGTTGA CTGTAGGCGC CCCTGGGGTG GGTTTAGCAG GCTGCAGCAG GCAGAGGAGG AGTACCCCCC TGAGAGCATG TGGGGGAAGG CCTTGCTGTC ATGTGAATCC CTCAATACCC CTAGTATCTG GCTGGGTTTT CAGGGGCTTT GGAAGCTCTG TTGCAGGTGT CCGGGGGTCT AGGACTTTAG GGATCTGGGA TCTGGGGAAG GACCAACCCA TGCCCTGCCA AGCCTGGAGC CCCTGTGTTG GGGGGCAAGG TGGGGGAGCC TGGAGCCCCT GTGTGGGAGG GCGAGGCGGG GGAGCCTGGA GCCCCTGTGT GGGAGGGCGA GGCGGGGGAT CCTGGAGCCC CTGTGTCGGG GGGCGAGGGA GGGGAGGTGG CCGTCGGTTG ACCTTCTGAA CATGAGTGTC AACTCCAGGA CTTGCTTCCA AGCCCTTCCC TCTGTTGGAA ATTGGGTGTG CCCTGGCTCC CAAGGGAGGC CCATGTGACT AATAAAAAAC TGTGAACCCT CGCATTTGTG TTTTAATAAA AGAATCTGGA AGATAAATAG TCTTGAAGAG AGACAAAGGA AGGAAAATTT AAATCCTTAG ATTCAAGCAG AAGAATTCCA TGTGGAAGGT TTGGGTTGTT GTTGTTGTTG TTTGGTGTGT TTTTTGTTTT TTTGTTTTTT TGTTTTTTTT TGAGATGGAG TCTCGCTGTG TTACCGGGAG CGACAGAGCC GCACGGCCGA GTCGAGTCCC AGCCAGCTAC CATCCCTCTG GAGCTTACCG GCCGGCCTTG GCTTCCCCAG GAATCCCTGG AGCTAGCGGC TGCTGAAGGC GTCGAGGTGT GGGGGCACTT GGACAGAACA GTCAGGCAGC CGGGAGCTCT GCCAGCTTTG GTGACCTTGG GTGCTTGCCT CGTGCCCCTT GGTGCCCGTC TGCTGATGTG CCCAGCCTGT GCCCGCCATG CCGCCCTCCA TCTCAGCTTT CCAGGCCGCC TACATCGGCA TCGAGGTGCT CATCGCCCTG GTCTCTGTGC CCGGGAACGT GCTGGTGATC TGGGCGGTGA AGGTGAACCA GGCGCTGCGG GATGCCACCT TCTGCTTCAT CGTGTCGCTG GCGGTGGCTG ATGTGGCCGT GGGTGCCCTG GTCATCCCCC TCGCCATCCT CATCAACATT GGGCCACAGA CCTACTTCCA CACCTGCCTC ATGGTTGCCT GTCCGGTCCT CATCCTCACC CAGAGCTCCA TCCTGGCCCT GCTGGCAATT GCTGTGGACC GCTACCTCCG GGTCAAGATC CCTCTCCGGT ACAAGATGGT GGTGACCCCC CGGAGGGCGG CGGTGGCCAT AGCCGGCTGC TGGATCCTCT CCTTCGTGGT GGGACTGACC CCTATGTTTG GCTGGAACAA TCTGAGTGCG GTGGAGCGGG CCTGGGCAGC CAACGGCAGC ATGGGGGAGC CCGTGATCAA GTGCGAGTTC GAGAAGGTCA TCAGCATGGA GTACATGGTC TACTTCAACT TCTTTGTGTG GGTGCTGCCC CCGCTTCTCC TCATGGTCCT EPI-109 575

CATCTACCTG GAGGTCTTCT ACCTAATCCG CAAGCAGCTC AACAAGAAGG TGTCGGCCTC CTCCGGCGAC

CCGCAGAAGT ACTATGGGAA GGAGCTGAAG ATCGCCAAGT CGCTGGCCCT CATCCTCTTC CTCTTTGCCC

TCAGCTGGCT GCCTTTGCAC ATCCTCAACT GCATCACCCT CTTCTGCCCG TCCTGCCACA AGCCCAGCAT

CCTTACCTAC ATTGCCATCT TCCTCACGCA CGGCAACTCG GCCATGAACC CCATTGTCTA TGCCTTCCGC

ATCCAGAAGT TCCGCGTCAC CTTCCTTAAG ATTTGGAATG ACCATTTCCG CTGCCAGCCT GCACCTCCCA

TTGACGAGGA TCTCCCAGAA GAGAGGCCTG ATGACTAGAC CCCGCCTTCC GCTCCCACCG CCCACATCCA

GTGGGGTCTC AGTCCAGTCC TCACATGCCC GCTGTCCCAG GGGTCTCCCT GAGCCTGCCC CAGCTGGGCT

GTTGGCTGGG GGCATGGGGG AGGCTCTGAA GAGATACCCA CAGAGTGTGG TCCCTCCACT AGGAGTTAAC

TACCCTACAC CTCTGGGCCC TGCAGGAGGC CTGGGAGGGC AAGGGTCCTA CGGAGGGACC AGGTGTCTAG

AGGCAACAGT GTTCTGAGCC CCCACCTGCC TGACCATCCC ATGAGCAGTC CAGAGCTTCA GGGCTGGGCA

GGTCCTGGGG AGGCTGAGAC TGCAGAGGAG CCACCTGGGC TGGGAGAAGG TGCTTGGGCT TCTGCGGTGA

GGCAGGGGAG TCTGCTTGTC TTAGATGTTG GTGGTGCAGC CCCAGGACCA AGCTTAAGGA GAGGAGAGCA

TCTGCTCTGA GACGGATGGA AGGAGAGAGG TTGAGGATGC ACTGGCCTGT TCTGTAGGAG AGACTGGCCA GA GAT

GGA GGG CGG CAT GGC GGG G CGG GTC GCC GG GGC GGG CBC BGG C GGC GGG CBC GC GGC CTG G

GGB GGG CGG C GBT GGB GGG GG CTG GGC GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC

GGG CAC AGG CTG GGC 5904

(2) INFORMATION FOR SEQ ID NO: 2424: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1681 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2424:

1 CCCAGCCCCG AGGCTCAGAA GCGGCAGGCG GAGGCGCGGT CCGGGCGCTA TGGCCATGCC

61 CGGCGGGTCT CACGCGGCTG CCCCTCGCCC GGCGCGCCTT CGGTAGGGGG CGCCCGGGGC

121 CCAGCTGGCC CGGCCATGCT GCTGGAGACA CAGGACGCGC TGTACGTGGC GCTGGAGCTG

181 GTCATCGCCG CGCTTTCGGT GGCGGGCAAC GTGCTGGTGT GCGCCGCGGT GGGCACGGCG

241 AACACTCTGC AGACGCCCAC CAACTACTTC CTGGTGTCCC TGGCTGCGGC CGACGTGGCC

301 GTGGGGCTCT TCGCCATCCC CTTTGCCATC ACCATCAGCC TGGGCTTCTG CACTGACTTC

361 TACGGCTGCC TCTTCCTCGC CTGCTTCGTG CTGGTGCTCA CGCAGAGCTC CATCTTCAGC

421 CTTCTGGCCG TGGCAGTCGA CAGATACCTG GCCATCTGTG TCCCGCTCAG GTATAAAAGT

481 TTGGTCACGG GGACCCGAGC AAGAGGGGTC ATTGCTGTCC TCTGGGTCCT TGCCTTTGGC

541 ATCGGATTGA CTCCATTCCT GGGGTGGAAC AGTAAAGACA GTGCCACCAA CAACTGCACA

601 GAACCCTGGG ATGGAACCAC GAATGAAAGC TGCTGCCTTG TGAAGTGTCT CTTTGAGAAT

661 GTGGTCCCCA TGAGCTACAT GGTATATTTC AATTTCTTTG GGTGTGTTCT GCCCCCACTG

721 CTTATAATGC TGGTGATCTA CATTAAGATC TTCCTGGTGG CCTGCAGGCA GCTTCAGCGC

781 ACTGAGCTGA TGGACCACTC GAGGACCACC CTCCAGCGGG AGATCCATGC AGCCAAGTCA

841 CTGGCCATGA TTGTGGGGAT TTTTGCCCTG TGCTGGTTAC CTGTGCATGC TGTTAACTGT

901 GTCACTCTTT TCCAGCCAGC TCAGGGTAAA AATAAGCCCA AGTGGGCAAT GAATATGGCC

961 ATTCTTCTGT CACATGCCAA TTCAGTTGTC AATCCCATTG TCTATGCTTA CCGGAACCGA

1021 GACTTCCGCT ACACTTTTCA CAAAATTATC TCCAGGTATC TTCTCTGCCA AGCAGATGTC

1081 AAGAGTGGGA ATGGTCAGGC TGGGGTACAG CCTGCTCTCG GTGTGGGCCT ATGATCTAGG

1141 CTCTCGCCTC TTCCAGGAGA AGATACAAAT CCACAAGAAA CAAAGAGGAC ACGGCTGGTT

1201 TTCATTGTGA AAGATAGCTA CACCTCACAA GGAAATGGAC TGCCTCTCTT GAGCACTTCC

1261 CTGGAGCTAC CACGTATCTA GCTAATATGT ATGTGTCAGT AGTAGCACCA AGGATTGACA

1321 AATATATTTA TGATCTATTC AGCTGCTTTT ACTGTGTGGA TTATGCCAAC AGCTTGAATG

1381 GATTCTAACA GACTCTTTTG TTTTTAAAAG TCTGCCTTGT TTATGGTGGA AAATTACTGA

1441 AACTATTTTA CTGTGAAACA GTGTGAACTA TTATAATGCA AATACTTTTT AACTTAGAGG

1501 CAATGGAAAA ATAAAAGTTG ACTGTACTAA AAATGTATAC TTGTTGCCAG GAAGGTGACC

1561 TCAAAAATTA AAAGTATAAT TATTCGGCCG GGCATGGTGG CTCACACCTG TAATTCCAGC

1621 ACTTTGGGAG GCCAAGGCAG GCGGATCACG AGGTCAGGAG TTCAAAACCA GCCTGTCCAA

1681 TATAGTG

(2) INFORMATION FOR SEQ ID NO: 2425: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1681 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2425:

1 GGGCAATTTG TTAGTTATCC GCCGCCACCA AGACGCGGCA CGGCGCCTGG ACCGGAGGGG

61 CCCCGCGCGG GCGCGAACTT TGGGCTCGGG CGAGTGGGTG GTGCTCCGCC CAGCCCGAGA

121 CGGGCGGGCG CGCGGGCCAA TGGGTGCCGC CTCTTGGCCG CGGGGGGCCC CGACCCGTGG

181 GTCCCGGCCA CCAGCGCCCC AGCCCCGAGG CTCAGAAGCG GCAGGCGGAG GCGCGGTCCG

241 GGCGCTATGG CCATGCCCGG CGGGTCTCAC GCGGCTGCCC CTCGCCCGGC GCGCCTTCGG

301 TAGGGGGCGC CCGGGGCCCA GCTGGCCCGG CCATGCTGCT GGAGACACAG GACGCGCTGT

361 ACGTGGCGCT GGAGCTGGTC ATCGCCGCGC TTTCGGTGGC GGGCAACGTG CTGGTGTGCG

421 CCGCGGTGGG CACGGCGAAC ACTCTGCAGA CGCCCACCAA CTACTTCCTG GTGTCCCTGG EPI-109 576

481 CTGCGGCCGA CGTGGCCGTG GGGCTCTTCG CCATCCCCTT TGCCATCACC ATCAGCCTGG

5 1 GCTTCTGCAC TGACTTCTAC GGCTGCCTCT TCCTCGCCTG CTTCGTGCTG GTGCTCACGC

601 AGAGCTCCAT CTTCAGCCTT CTGGCCGTGG CAGTCGACAG ATACCTGGCC ATCTGTGTCC

661 CGCTCAGGTA TAAAAGTTTG GTCACGGGGA CCCGAGCAAG AGGGGTCATT GCTGTCCTCT

721 GGGTCCTTGC CTTTGGCATC GGATTGACTC CATTCCTGGG GTGGAACAGT AAAGACAGTG

781 CCACCAACAA CTGCACAGAA CCCTGGGATG GAACCACGAA TGAAAGCTGC TGCCTTGTGA

841 AGTGTCTCTT TGAGAATGTG GTCCCCATGA GCTACATGGT ATATTTCAAT TTCTTTGGGT

901 GTGTTCTGCC CCCACTGCTT ATAATGCTGG TGATCTACAT TAAGATCTTC CTGGTGGCCT

961 GCAGGCAGCT TCAGCGCACT GAGCTGATGG ACCACTCGAG GACCACCCTC CAGCGGGAGA

1021 TCCATGCAGC CAAGTCACTG GCCATGATTG TGGGGATTTT TGCCCTGTGC TGGTTACCTG

1081 TGCATGCTGT TAACTGTGTC ACTCTTTTCC AGCCAGCTCA GGGTAAAAAT AAGCCCAAGT

1141 GGGCAATGAA TATGGCCATT CTTCTGTCAC ATGCCAATTC AGTTGTCAAT CCCATTGTCT

1201 ATGCTTACCG GAACCGAGAC TTCCGCTACA CTTTTCACAA AATTATCTCC AGGTATCTTC

1261 TCTGCCAAGC AGATGTCAAG AGTGGGAATG GTCAGGCTGG GGTACAGCCT GCTCTCGGTG

1321 TGGGCCTATG ATCTAGGCTC TCGCCTCTTC CAGGAGAAGA TACAAATCCA CAAGAAACAA

1381 AGAGGACACG GCTGGTTTTC ATTGTGAAAG ATAGCTACAC CTCACAAGGA AATGGACTGC

1441 CTCTCTTGAG CACTTCCCTG GAGCTACCAC GTATCTAGCT AATATGTATG TGTCAGTAGT

1501 AGGCTCCAAG GATTGACAAA TATATTTATG ATCTATTCAG CTGCTTTTAC TGTGTGGATT

1561 ATGCCAACAG CTTGAATGGA TTCTAACAGA CTCTTTTGTT TTTAAAAGTC TGCCTTGTTT

1621 ATGGTGGAAA ATTACTGAAA CTATTTTACT GTGAAACAGT GTGAACTATT ATAATGCAAA

1681 TACTTTTTAA CTTAGAGGCA ATGGAAAAAT AAAAGTTGAC TGTACTAAAA ATG

(2) INFORMATION FOR SEQ ID NO:2426: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2461 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2426:

1 GAATTCCCAG ATGGGCAGAG GTGGCTGGGC TGGTGACCCT AAGTGTGTCT CCTGCCTTTA

61 TTCTCTCTAG TGGGTTATTC TTTCATGTGG TATCTTGCCT ACAGCATGCT GTGTTTGGAC

121 ACAAACCCCT TTCCTTGGTT TCTCTGACCC AGCTGAGATG GACTGATTCC AAAAGAACTC

181 ACCTATGTAC TGGGGTAGGG GAGGGAGGGT TTTTTGCAGT ATTTAACTAA GGTTCAAAGA

241 GTGCTATATA GTGAGAAAGG CTTCTTTTTT TTTTTTTTTT TTTTTTGGCA GAGTGCTGCC

301 TCCTAGAAAT TTCTCTTGGT AACTTCCTTC TCTGAAGCAC AGATAAAGAA AACAATTACA

361 GTAGAAACAT TTATGAGGGA CACATTGGAG GCCGATGAAG CTTTTCAAGT TCCAGCAGTG

421 CAGGGATGTG GGCAGAACTG ACATTGGAAA ATACTAGAAT GATGGAAATT CAGTTGGAGA

481 GGACTGCCCT TTTTAATGTC TGGGGAGTCT GCTCAGGGAG AAATGACAAG TCTGGCGGGG

541 ACAAGTATGG GATTTGGTAA GACTTGGATC AACTTGGGAT ACAGGGTGGG GGTCGGGAGT

601 GGAATCAATG AATGATGCCA GAGCAGATCA ACTAACAAGA GGACCCTGAT GAGCCCCAGG

661 CAGAGGCGTC TCCCTTATGC CCCACTCTGA AGTGTTTGTT AGTAAACACC AGAACGCCAT

721 TGTTGTTACT GCTGAATTTT ATTTTGGGCT GTACATATTT AGATGCTTAA GGTAAAAATG

781 ATAAAGCCCT CAAGCCACTG TGTGGGTTTG GGTCCAAGTG TTCCTTCTTG CTGCCTCTCT

841 AACACGCCTG GTTAAAATAA TCCCTTTGGA TGGTGCTGAG AAGCACCTGA ACCAAGTGGG

901 TCCCCAAATA ACAATGGCGT GCAAGTGTCT GGTTCCCAGA AGTTGGTGAC TAGGTAAGCA

961 GCTTCAGGGA GAGGGGGCTG ATTCCCAGAC AGTCGCCTGT TCCTGCGGGG ATGGGGCTGA

1021 GGCTTGGGGA ATGTGGGCAG GAGGATATGC CATTTGATTC TGTTGCACAC GTTCTTTTCC

1081 CTTCTTTCTG TATGTCTGGT CATTCTGCTA TTCTGTCGTT CCTCACATAG GTTGGACATT

1141 GGCCGGCTGC CAGCATAAGT GCCAGTGTGA TTTTGCTAGG TGTGAGCTGA GAAAGAGAGG

1201 TGGAGGCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG TTTTTGCCCT TCTGAGCAGG

1261 GAATCTTTGC TTATCCCTTT GACCAAGGAT CTTTGCTGCA AAGGCTGGGT ATCGGCTGTG

1321 CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGGTTAGGA

1381 GGCTGCCACC AAAGTCTCTT TTTTGTTCCT CTGCTTCTCC CGTTTGCCTC CTTATCATGA

1441 GATCTTTTTG CTAAGCTGGC AGAAAGATTG CATAGTCAGT GCTTCCAGCT CTGCTCCCAC

1501 CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC

1561 GAGCCTTCTC TATGCCACTC ATGGCTCCTC TTCTGCTCTT TCCATCTTTT TGCTGAGAGT

1621 TCTGAGCTCT GTACTTCCTC TTGGCCCATC TCACTTCCTG AAACACCCCT GAAGAGGGTT

1681 GCTTATCTTG ATGGAACTCA AAAAGCCAAA AAGCTGCAGG CAGAGGCGTT GAGGACATCT

1741 GTTTGGGGAA CTAAGAGCAG CAGCACTTTC AGATTCAGTC CATATAGAGC TGTCCTACAG 1801 CATTCTGGAA ACTTGAGGAT GTGCGGTGCA TAAAGGGGCT GGAAGTGACC CACCTGTGAT

1861 GAGCCCTTTC TAAGGAGAAG GGTTTCCAAG AGATCACCCC ACCAGAAAAG GGTAGGAATG 1921 AGCAAGTTGG GAATTTTAGA CTGTCACTGC ACATGGACCT CTGGGAAGAC GTCTGGCGAG 1981 AGCTAGGCCC ACTGGCCCTA CAGACGGATC TTGCTGGCTC ACCTGTCCCT GTGGAGGTTC 2041 CCCTGGGAAG GCAAGATGCC CAACAACAGC ACTGCTCTGT CATTGGCCAA TGTTACCTAC 2101 ATCACCATGG AAATTTTCAT TGGACTCTGC GCCATAGTGG GCAACGTGCT GGTCATCTGC 2161 GTGGTCAAGC TGAACCCCAG CCTGCAGACC ACCACCTTCT ATTTCATTGT CTCTCTAGCC 2221 CTGGCTGACA TTGCTGTTGG GGTGCTGGTC ATGCCTTTGG CCATTGTTGT CAGCCTGGGC 2281 ATCACAATCC ACTTCTACAG CTGCCTTTTT ATGACTTGCC TACTGCTTAT CTTTACCCAC 2341 GCCTCCATCA TGTCCTTGCT GGCCATCGCT GTGGACCGAT ACTTGCGGGT CAAGCTTACC EPI-109 577

2401 GTCAGGTAGC CTGCGGCGTG GGGTGGGCAG CAATTGAGGC AGCTGGGAAA TGAGGCTACA 2461 AAGCCAGAGC

(2) INFORMATION FOR SEQ ID NO: 2427: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1741 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2427:

1 CGAATTCGGG GGACATCTGT TTGGGGAACT AAGAGCAGCA GCACTTTCAG ATTCAGTCCA

61 TATAGAGCTG TCCTACAGCA TTCTGGAAAC TTGAGGATGT GCGGTGCATA AACGGGCTGG

121 AAGTGACCCA CCTGTGATGA GCCCTTTCTA AGGAGAAGGG TTTCCAAGAG ATCACCCCAC

181 CAGAAAAGGG TAGGAATGAG CAAGTTGGGA ATTTTAGACT GTCACTGCAC ATGGACCTCT

241 GGGAAGACGT CTGGCGAGAG CTAGGCCCAC TGGCCCTACA GACGGATCTT GCTGGCTCAC

301 CTGTCCCTGT GGAGGTTCCC CTGGGAAGGC AAGATGCCCA ACAACAGCAC TGCTCTGTCA

361 TTGGCCAATG TTACCTACAT CACCATGGAA ATTTTCATTG GACTCTGCGC CATAGTGGGC

421 AACGTGCTGG TCATCTGCGT GGTCAAGCTG AACCCCAGCC TGCAGACCAC CACCTTCTAT

481 TTCATTGTCT CTCTAGCCCT GGCTGACATT GCTGTTGGGG TGCTGGTCAT GCCTTTGGCC

541 ATTGTTGTCA GCCTGGGCAT CACAATCCAC TTCTACAGCT GCCTTTTTAT GACTTGCCTA

601 CTGCTTATCT TTACCCACGC CTCCATCATG TCCTTGCTGG CCATCGCTGT GGACCGATAC

661 TTGCGGGTCA AGCTTACCGT CAGATACAAG AGGGTCACCA CTCACAGAAG AATATGGCTG

721 GCCCTGGGCC TTTGCTGGCT GGTGTCATTC CTGGTGGGAT TGACCCCCAT GTTTGGCTGG

781 AACATGAAAC TGACCTCAGA GTACCACAGA AATGTCACCT TCCTTTCATG CCAATTTGTT

841 TCCGTCATGA GGATGGACTA CATGGTATAC TTCAGCTTCC TCACCTGGAT TTTCATCCCC

901 CTGGTTGTCA TGTGCGCCAT CTATCTTGAC ATCTTTTACA TCATTCGGAA CAAACTCAGT

961 CTGAACTTAT CTAACTCCAA AGAGACAGGT GCATTTTATG GACGGGAGTT CAAGACGGCT

1021 AAGTCCTTGT TTCTGGTTCT TTTCTTGTTT GCTCTGTCAT GGCTGCCTTT ATCTCTCATC

1081 AACTGCATCA TCTACTTTAA TGGTGAGGTA CCACAGCTTG TGCTGTACAT GGGCATCCTG

1141 CTGTCCCATG CCAACTCCAT GATGAACCCT ATCGTCTATG CCTATAAAAT AAAGAAGTTC

1201 AAGGAAACCT ACCTTTTGAT CCTCAAAGCC TGTGTGGTCT GCCATCCCTC TGATTCTTTG

1261 GACACAAGCA TTGAGAAGAA TTCTGAGTAG TTATCCATCA GAGATGACTC TGTCTCATTG

1321 ACCTTCAGAT TCCCCATCAA CAAACACTTG AGGGCCTGTA TGCCTGGGCC AAGGGATTTT

1381 TACATCCTTG ATTACTTCCA CTGAGGTGGG AGCATCTCCA GTGCTCCCCA ATTATATCTC

1441 CCCCACTCCA CTACTCTCTT CCTCCACTTC ATTTTTCCTT TGTCCTTTCT CTCTAATTCA

1501 GTGTTTTGGA GGCCTGACTT GGGGACAACG TATTATTGAT ATTATTGTCT GTTTTCCTTC

1561 TTCCCAATAG AAGAATAAGT CATGGAGCCT GAAGGGTGCC TAGTTGACTT ACTGACAAAA

1621 GGCTCTAGTT GGGCTGAACA TGTGTGTGGT GGTGACTCAT TTCCATGCCA TTGTGGAATT

1681 GAGCAGAGAA CCTGCTCTCG GAGGATGCCT AGGAGATGTT GGGAACAGAA GAAATAAACT

1741 GAGTTTAAGG GGGACTTAAA CTGCTGAATT C

(2) INFORMATION FOR SEQ ID NO:2428: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2041 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2428:

1 GCCGCCGCCG CCAAGATGGC GGACCTGGAG GCGGTGCTGG CCGACGTGAG CTACCTGATG

61 GCCATGGAGA AGAGCAAGGC CACGCCGGCC GCGCGCGCCA GCAAGAAGAT ACTGCTGCCC

121 GAGCCCAGCA TCCGCAGTGT CATGCAGAAG TACCTGGAGG ACCGGGGCGA GGTGACCTTT

181 GAGAAGATCT TTTCCCAGAA GCTGGGGTAC CTGCTCTTCC GAGACTTCTG CCTGAACCAC

241 CTGGAGGAGG CCAGGCCCTT GGTGGAATTC TATGAGGAGA TCAAGAAGTA CGAGAAGCTG

301 GAGACGGAGG AGGAGCGTGT GGCCCGCAGC CGGGAGATCT TCGACTCATA CATCATGAAG

361 GAGCTGCTGG CCTGCTCGCA TCCCTTCTCG AAGAGTGCCA CTGAGCATGT CCAAGGCCAC

421 CTGGGGAAGA AGCAGGTGCC TCCGGATCTC TTCCAGCCAT ACATCGAAGA GATTTGTCAA

481 AACCTCCGAG GGGACGTGTT CCAGAAATTC ATTGAGAGCG ATAAGTTCAC ACGGTTTTGC

541 CAGTGGAAGA ATGTGGAGCT CAACATCCAC CTGACCATGA ATGACTTCAG CGTGCATCGC

601 ATCATTGGGC GCGGGGGCTT TGGCGAGGTC TATGGGTGCC GGAAGGCTGA CACAGGCAAG

661 ATGTACGCCA TGAAGTGCCT GGACAAAAAG CGCATCAAGA TGAAGCAGGG GGAGACCCTG

721 GCCCTGAACG AGCGCATCAT GCTCTCGCTC GTCAGCACTG GGGACTGCCC ATTCATTGTC

781 TGCATGTCAT ACGCGTTCCA CACGCCAGAC AAGCTCAGCT TCATCCTGGA CCTCATGAAC

841 GGTGGGGACC TGCACTACCA CCTCTCCCAG CACGGGGTCT TCTCAGAGGC TGACATGCGC

901 TTCTATGCGG CCGAGATCAT CCTGGGCCTG GAGCACATGC ACAACCGCTT CGTGGTCTAC

961 CGGGACCTGA AGCCAGCCAA CATCCTTCTG GACGAGCATG GCCACGTGCG GATCTCGGAC

1021 CTGGGCCTGG CCTGTGACTT CTCCAAGAAG AAGCCCCATG CCAGCGTGGG CACCCACGGG

1081 TACATGGCTC CGGAGGTCCT GCAGAAGGGC GTGGCCTACG ACAGCAGTGC CGACTGGTTC

1141 TCTCTGGGGT GCATGCTCTT CAAGTTGCTG CGGGGGCACA GCCCCTTCCG GCAGCACAAG

1201 ACCAAAGACA AGCATGAGAT CGACCGCATG ACGCTGACGA TGGCCGTGGA GCTGCCCGAC EPI-109 578

1261 TCCTTCTCCC CTGAACTACG CTCCCTGCTG GAGGGGTTGC TGCAGAGGGA TGTCAACCGG 1321 AGATTGGGCT GCCTGGGCCG AGGGGCTCAG GAGGTGAAAG AGAGCCCCTT TTTCCGCTCC 1381 CTGGACTGGC AGATGGTCTT CTTGCAGAAG TACCCTCCCC CGCTGATCCC CCCACGAGGG 1441 GAGGTGAACG CGGCCGACGC CTTCGACATT GGCTCCTTCG ATGAGGAGGA CACAAAAGGA 1501 ATCAAGTTAC TGGACAGTGA TCAGGAGCTC TACCGCAACT TCCCCCTCAC CATCTCGGAG 1561 CGGTGGCAGC AGGAGGTGGC AGAGACTGTC TTCGACACCA TCAACGCTGA GACAGACCGG 1621 CTGGAGGCTC GCAAGAAAGC CAAGAACAAG CAGCTGGGCC ATGAGGAAGA CTACGCCCTG 1681 GGCAAGGACT GCATCATGCA TGGCTACATG TCCAAGATGG GCAACCCCTT CCTGACCCAG 1741 TGGCAGCGGC GGTACTTCTA CCTGTTCCCC AACCGCCTCG AGTGGCGGGG CGAGGGCGAG 1801 GCCCCGCAGA GCCTGCTGAC CATGGAGGAG ATCCAGTCGG TGGAGGAGAC GCAGATCAAG 1861 GAGCGCAAGT GCCTGCTCCT CAAGATCCGC GGTGGGAAAC AGTTCATTTT GCAGTGCGAT 1921 AGCGACCCTG AGCTGGTGCA GTGGAAGAAG GAGCTGCGCG ACGCCTACCG CGAGGCCCAG 1981 CAGCTGGTGC AGCGGGTGCC CAAGATGAAG AACAAGCCGC GCTCGCCCGT GGTGGAGCTG 2041 AGCAAGGTGC CGCTGGTCCA GCGCGGCAGT GCCAACGGCC TCTGACCCGC CCACCCGCCT

(2) INFORMATION FOR SEQ ID NO:2429: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2341 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2429: 1 CCAGGAAGCT ACCTGGAGGA GGTGAGTCTT AGCGGATGAG TAGGAGTTGT CCACGGAGGA

61 AGGTACACAG AAGGGCTTCC AGGCCCAGGA AACAGCAGAG GCACAGAAGT GAGAATGGGT

121 GGGTGAGTTG GTGGGGAAAC TCCAGGTGCA GAGGATGGTA GCGAAACAAA CTGGAGCATT

181 AAGGTCCAAG TCCTCCAAGA TCTTGACTTG CAGATTAAGG AGTTTGTTCA CCTAATCTGC

241 TTTGGGCAGA GTGTGGTGAG TCCTAGAGAC CCCTCTAGGT CTCTCCTCTC AGTAGCCCCA

301 GAAGGCCTGG AGAGCTGCTT CTGGGTGCCA AGCAGGCAGT GACTCCATCA GATCTAGATT

361 TGGGAAAAGC ATCCCTGGTC AGGGCCTGCA TCAGGGCAGT GGCTGGCCAT GAGGACCCTG

421 AGAAGTAGAC AGATTCACGG AGATTCTCAG GAGGCCAGAC AGGAGACTAT GGTGACAAAT

481 TAGATTAGAG AAGGGGAGAG AATGAAGGAG CAGTTGGGGT AAAAGAAAAC TGAGGCTGAC

541 ATGGGTATAT GGGTGGCGAG TGACTCACCA CCCACTGAGA GGAGAACCTC ACAAGCTCTG

601 ACATGCTCTG GTTCCAGGTT CTGTTGGGGC TGATCCAAGA TGGTAGCCTA GAGGTGCACA

661 GAGATGGGGG CCTTGCTTTG CAAAAGGATG CTGGCTGCTG GCCCACAGCA TGGTAATGAG

721 ATTTGAGCTT TATGTGCCCA GGGCTGGGAG GAGGGTCCTG TCACTTTGAA AGCAAAGAGA

781 GGCTCTAGAG AGGGGCATGT TGAGATAGGA ATGCTGCCTT GAGACACCTG GCTTTCCCCA

841 CTCTGGGTGG CTCTCAGCAG GGTGGGTTTC CCCTGCCAGG CAGCACTGAA CCTCTGTGCG

901 CTTCCGGCTG GGAGAGTTTT TACCGTAACT ACATGTGGAA CCATCCTGAA GGAACATCTG

961 GATGGGATGG GGTACAGGGA AGGGAGCTGC CAAGAGTGCT GGCCAGGGAC CTGGGTCTAT

1021 GAGCTGGTTG GGGGGTGGGG TTGGGTGCAG GGTACTTGAT CCTGAGTGGG CCTTCTGCGG

1081 CCAGGATTGG TTCTAGAGTA GGAGGGGTGG GATCGGGGAT GGGGGAAGCC TGTAACTGCG

1141 CTGCAGTTGT CAGGTCCCAG GTTCTGGGTG ACCTACTAAG GATTCTGGGT CCAGTGTGGG

1201 TCCCAGGTTA GACGTCCTAG TCCTGAGTCC GTGTCCACAG TTCTGGGTGT TGAGTCTAGG

1261 ACAGTGATCT GGAGTTGACA GTCCAATCTA GGTCTGAGTC CTGACCCCAA GTCTAGAGTT

1321 CAGGGTCATG GTAGTAGCCT AGGGTCAGAA TCAAGGTTGG GGTCAGTAAC CAGGATGGGA

1381 TCGAGGTCAT GGTCCAAAAT CTGGATCTGG GGACCTGTTG GGGGTCTGAG GTGAGTGTCG

1441 CAGTCTGGGT ATGGCGTTGG AGACCCAGGG CTGTGATCTG AGGTCATGGT TAGAGTCTCA

1501 GGTGGTGGGG CAAGGTTTGA GTCTGGGGTC CTGTTTGGAG TCTGGTGTCA GGTCGTGGAC

1561 TGCGTCCAAG GTCAGGGAGT CCGGGGTTAT AGCCAGGGTC TGAGATGAAA GTCCCAGATG

1621 GTGTTCAGAG GTCTGAATCT GTGTCTTGGT GAGCGTCCAG GTTCCCTGTG ATCACGTTTG

1681 GTGTCAGGGC TGCGGCCCGA CTGGGGAGCC TGGGATCCAG AGATGTGACC CGAGGTTGTG

1741 GTCAGAGAAT GGGTCTCGGG TCGTCTTCGT GCCGGGTCCC TGTCGTGTTC CAGGCCCGGG 1801 TCTCCGTCCA GCATCGAGGG CCGAGGTCAC GGCCAGGGTC TGAGCCCGCG GTCGCAGGTC

1861 TGGTTCGGGG TCAGATTCCG CGCGGCCTCC AGGGGGCGCC GTCGCCGCCC GGCTCGGCCC 1921 CTCGCGGGCT CGCTGGCGTT GTGCGCGGCA GGCGGGGCCG GAGGCGGCGG CGGCTCCGGG 1981 GGCGCGGGCC GGGCGGCGGC GGCGGCGGCG CCCCGACTGC AGTCCCGGCG GGAGCGGAGC 2041 GCGAAGCGCG GGGCCGGGCC CGGAGCCGGC GCCATGGGGC GGCGCCGCCT GTGAGCGGCG 2101 GCGAGCGGAG CCGCGGGCGC CGAGCAGGGC CAGGCGGGAG CGTCGGCGCC CGAGGCCGAG 2161 CGAGCCGCGG CCGGGCCGGG CCGAGCGCCG AGCGAGCAGG AGCGGCGGCG GCGGCGGCGG 2221 CGGCGGGAGG AGGCAGCGCC GCCGCCAAGA TGGCGGACCT GGAGGCGGTG CTGGCCGACG 2281 TGAGCTACCT GATGGCCATG GAGAAGAGCA AGGCCACGCC GGCCGCGCGC GCCAGCAAGA 2341 AGATACTGCT GCCCGAGCCC AGGTGAGGAG AAGCT

(2) INFORMATION FOR SEQ ID NO:2430: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4382 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear EPI-109 579

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2430: GCCGCCGCCG CCAAGATGGC GGACCTGGAG GCGGTGCTGG CCGACGTGAG CTACCTGATG GCCATGGAGA AGAGCAAGGC CACGCCGGCC GCGCGCGCCA GCAAGAAGAT ACTGCTGCCC GAGCCCAGCA TCCGCAGTGT CATGCAGAAG TACCTGGAGG ACCGGGGCGA GGTGACCTTT GAGAAGATCT TTTCCCAGAA GCTGGGGTAC CTGCTCTTCC GAGACTTCTG CCTGAACCAC CTGGAGGAGG CCAGGCCCTT GGTGGAATTC TATGAGGAGA TCAAGAAGTA CGAGAAGCTG GAGACGGAGG AGGAGCGTGT GGCCCGCAGC CGGGAGATCT TCGACTCATA CATCATGAAG GAGCTGCTGG CCTGCTCGCA TCCCTTCTCG AAGAGTGCCA CTGAGCATGT CCAAGGCCAC CTGGGGAAGA AGCAGGTGCC TCCGGATCTC TTCCAGCCAT ACATCGAAGA GATTTGTCAA AACCTCCGAG GGGACGTGTT CCAGAAATTC ATTGAGAGCG ATAAGTTCAC ACGGTTTTGC CAGTGGAAGA ATGTGGAGCT CAACATCCAC CTGACCATGA ATGACTTCAG CGTGCATCGC ATCATTGGGC GCGGGGGCTT TGGCGAGGTC TATGGGTGCC GGAAGGCTGA CACAGGCAAG ATGTACGCCA TGAAGTGCCT GGACAAAAAG CGCATCAAGA TGAAGCAGGG GGAGACCCTG GCCCTGAACG AGCGCATCAT GCTCTCGCTC GTCAGCACTG GGGACTGCCC ATTCATTGTC TGCATGTCAT ACGCGTTCCA CACGCCAGAC AAGCTCAGCT TCATCCTGGA CCTCATGAAC GGTGGGGACC TGCACTACCA CCTCTCCCAG CACGGGGTCT TCTCAGAGGC TGACATGCGC TTCTATGCGG CCGAGATCAT CCTGGGCCTG GAGCACATGC ACAACCGCTT CGTGGTCTAC CGGGACCTGA AGCCAGCCAA CATCCTTCTG GACGAGCATG GCCACGTGCG GATCTCGGAC CTGGGCCTGG CCTGTGACTT CTCCAAGAAG AAGCCCCATG CCAGCGTGGG CACCCACGGG TACATGGCTC CGGAGGTCCT GCAGAAGGGC GTGGCCTACG ACAGCAGTGC CGACTGGTTC TCTCTGGGGT GCATGCTCTT CAAGTTGCTG CGGGGGCACA GCCCCTTCCG GCAGCACAAG ACCAAAGACA AGCATGAGAT CGACCGCATG ACGCTGACGA TGGCCGTGGA GCTGCCCGAC TCCTTCTCCC CTGAACTACG CTCCCTGCTG GAGGGGTTGC TGCAGAGGGA TGTCAACCGG AGATTGGGCT GCCTGGGCCG AGGGGCTCAG GAGGTGAAAG AGAGCCCCTT TTTCCGCTCC CTGGACTGGC AGATGGTCTT CTTGCAGAAG TACCCTCCCC CGCTGATCCC CCCACGAGGG GAGGTGAACG CGGCCGACGC CTTCGACATT GGCTCCTTCG ATGAGGAGGA CACAAAAGGA ATCAAGTTAC TGGACAGTGA TCAGGAGCTC TACCGCAACT TCCCCCTCAC CATCTCGGAG CGGTGGCAGC AGGAGGTGGC AGAGACTGTC TTCGACACCA TCAACGCTGA GACAGACCGG CTGGAGGCTC GCAAGAAAGC CAAGAACAAG CAGCTGGGCC ATGAGGAAGA CTACGCCCTG GGCAAGGACT GCATCATGCA TGGCTACATG TCCAAGATGG GCAACCCCTT CCTGACCCAG TGGCAGCGGC GGTACTTCTA CCTGTTCCCC AACCGCCTCG AGTGGCGGGG CGAGGGCGAG GCCCCGCAGA GCCTGCTGAC CATGGAGGAG ATCCAGTCGG TGGAGGAGAC GCAGATCAAG GAGCGCAAGT GCCTGCTCCT CAAGATCCGC GGTGGGAAAC AGTTCATTTT GCAGTGCGAT AGCGACCCTG AGCTGGTGCA GTGGAAGAAG GAGCTGCGCG ACGCCTACCG CGAGGCCCAG CAGCTGGTGC AGCGGGTGCC CAAGATGAAG AACAAGCCGC GCTCGCCCGT GGTGGAGCTG AGCAAGGTGC CGCTGGTCCA GCGCGGCAGT GCCAACGGCC TCTGACCCGC CCACCCGCCT CCAGGAAGCT ACCTGGAGGA GGTGAGTCTT AGCGGATGAG TAGGAGTTGT CCACGGAGGA AGGTACACAG AAGGGCTTCC AGGCCCAGGA AACAGCAGAG GCACAGAAGT GAGAATGGGT GGGTGAGTTG GTGGGGAAAC TCCAGGTGCA GAGGATGGTA GCGAAACAAA CTGGAGCATT AAGGTCCAAG TCCTCCAAGA TCTTGACTTG CAGATTAAGG AGTTTGTTCA CCTAATCTGC TTTGGGCAGA GTGTGGTGAG TCCTAGAGAC CCCTCTAGGT CTCTCCTCTC AGTAGCCCCA GAAGGCCTGG AGAGCTGCTT CTGGGTGCCA AGCAGGCAGT GACTCCATCA GATCTAGATT TGGGAAAAGC ATCCCTGGTC AGGGCCTGCA TCAGGGCAGT GGCTGGCCAT GAGGACCCTG AGAAGTAGAC AGATTCACGG AGATTCTCAG GAGGCCAGAC AGGAGACTAT GGTGACAAAT TAGATTAGAG AAGGGGAGAG AATGAAGGAG CAGTTGGGGT AAAAGAAAAC TGAGGCTGAC ATGGGTATAT GGGTGGCGAG TGACTCACCA CCCACTGAGA GGAGAACCTC ACAAGCTCTG ACATGCTCTG GTTCCAGGTT CTGTTGGGGC TGATCCAAGA TGGTAGCCTA GAGGTGCACA GAGATGGGGG CCTTGCTTTG CAAAAGGATG CTGGCTGCTG GCCCACAGCA TGGTAATGAG ATTTGAGCTT TATGTGCCCA GGGCTGGGAG GAGGGTCCTG TCACTTTGAA AGCAAAGAGA GGCTCTAGAG AGGGGCATGT TGAGATAGGA ATGCTGCCTT GAGACACCTG GCTTTCCCCA CTCTGGGTGG CTCTCAGCAG GGTGGGTTTC CCCTGCCAGG CAGCACTGAA CCTCTGTGCG CTTCCGGCTG GGAGAGTTTT TACCGTAACT ACATGTGGAA CCATCCTGAA GGAACATCTG GATGGGATGG GGTACAGGGA AGGGAGCTGC CAAGAGTGCT GGCCAGGGAC CTGGGTCTAT GAGCTGGTTG GGGGGTGGGG TTGGGTGCAG GGTACTTGAT CCTGAGTGGG CCTTCTGCGG CCAGGATTGG TTCTAGAGTA GGAGGGGTGG GATCGGGGAT GGGGGAAGCC TGTAACTGCG CTGCAGTTGT CAGGTCCCAG GTTCTGGGTG ACCTACTAAG GATTCTGGGT CCAGTGTGGG TCCCAGGTTA GACGTCCTAG TCCTGAGTCC GTGTCCACAG TTCTGGGTGT TGAGTCTAGG ACAGTGATCT GGAGTTGACA GTCCAATCTA GGTCTGAGTC CTGACCCCAA GTCTAGAGTT CAGGGTCATG GTAGTAGCCT AGGGTCAGAA TCAAGGTTGG GGTCAGTAAC CAGGATGGGA TCGAGGTCAT GGTCCAAAAT CTGGATCTGG GGACCTGTTG GGGGTCTGAG GTGAGTGTCG CAGTCTGGGT ATGGCGTTGG AGACCCAGGG CTGTGATCTG AGGTCATGGT TAGAGTCTCA GGTGGTGGGC CAAGGTTTGA GTCTGGGGTC CTGTTTGGAG TCTGGTGTCA GGTCGTGGAC TGCGTCCAAG GTCAGGGAGT CCGGGGTTAT AGCCAGGGTC TGAGATGAAA GTCCCAGATG GTGTTCAGAG GTCTGAATCT GTGTCTTGGT GAGCGTCCAG GTTCCCTGTG ATCACGTTTG GTGTCAGGGC TGCGGCCCGA CTGGGGAGCC TGGGATCCAG AGATGTGACC CGAGGTTGTG GTCAGAGAAT GGGTCTCGGG TCGTCTTCGT GCCGGGTCCC TGTCGTGTTC CAGGCCCGGG TCTCCGTCCA GCATCGAGGG CCGAGGTCAC GGCCAGGGTC TGAGCCCGCG GTCGCAGGTC TGGTTCGGGG TCAGATTCCG CGCGGCCTCC AGGGGGCGCC GTCGCCGCCC GGCTCGGCCC CTCGCGGGCT CGCTGGCGTT GTGCGCGGCA GGCGGGGCCG GAGGCGGCGG CGGCTCCGGG GGCGCGGGCC GGGCGGCGGC GGCGGCGGCG CCCCGACTGC AGTCCCGGCG GGAGCGGAGC GCGAAGCGCG GGGCCGGGCC CGGAGCCGGC GCCATGGGGC GGCGCCGCCT GTGAGCGGCG GCGAGCGGAG CCGCGGGCGC CGAGCAGGGC CAGGCGGGAG CGTCGGCGCC CGAGGCCGAG CGAGCCGCGG CCGGGCCGGG CCGAGCGCCG AGCGAGCAGG AGCGGCGGCG GCGGCGGCGG CGGCGGGAGG AGGCAGCGCC GCCGCCAAGA TGGCGGACCT GGAGGCGGTG CTGGCCGACG TGAGCTACCT GATGGCCATG GAGAAGAGCA AGGCCACGCC GGCCGCGCGC GCCAGCAAGA AGATACTGCT GCCCGAGCCC AGGTGAGGAG AAGCT 4382

(2) INFORMATION FOR SEQ ID NO:2431: EPI-109 580

( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2581 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2431:

1 CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT

61 GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC

121 AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG

181 ACTAATTCCT GCCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA

241 CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT

301 GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG

361 AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG

421 AACTGCCATC CAGCTTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT

481 CTTTAATCTA TTCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC

541 CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA

601 CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA TTGAGCACTT GCTGTATATG

661 CAGTATTGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCTTGAAGG

721 AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAAGC TGTTCGACGA

781 GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA

841 GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTT TTATGTAACA

901 TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG

961 TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA

1021 AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC

1081 GGTGTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTT CCACCTGTCA

1141 TTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCATTTGGAG AGAAGGCCAT

1201 GTCTTCAAAG TCTGATTTGT GATGAGGCAG AGGAAGATAT TTCTAATCGG TCTTGCCCAG

1261 AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG

1321 GCCTGCTCAG GGACTGTTCC TGTCTCAGCA ACCAAGGGAT TGTTCCTGTC AATCAATGGT

1381 TTATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGTGT

1441 TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT AAATGAATAT TTATTAGCTG

1501 GTTGGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA

1561 CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT

1621 AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA

1681 ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA

1741 ACCTAGAAGG GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG

1801 AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGTTA

1861 GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC

1921 TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC

1981 TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATTTACAT

2041 GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAAT TTTAAAGCAA AAGCGTGAAA

2101 AAAAAGATTC CCTCCTTACC CCCAACCCAC TCTTTTTTCC CACCACCCAC TCTCCTCTGC

2161 CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATTTAGTATT

2221 AGTATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC

2281 TGTGTTTTGT CACACAGGGC AGTCATTCAG CACCAGAGCA CGTGATGGTC TGAGACTCTC

2341 TTAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA

2401 CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC

2461 TGTCCTGTGA AAGACTCAAT GAGCTGTTAT GTTGTAAACA GGAAGCATTT CACATCCAAA

2521 CGAGAAAATC ATGTAAACAT GTGTCTTTTC TGTAGAGCAT AATAAATGGA TGAGGTTTTT

2581 GCAAAAAAAA AAAAAAAAA

(2) INFORMATION FOR SEQ ID NO: 2432: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 961 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2432:

1 ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC 61 CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG 121 CGGGATGCCA CCTTCTGCTT CATCGTCTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC 181 CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC 241 CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA 301 ATTGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC 361 CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG 421 ACCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC 481 AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG 541 GTCTACTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC EPI-109 581

601 CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC

661 GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC

721 TTCCTCTTTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC

781 CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC

841 TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT

901 AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA

961 GAAGAGAGGC CTGATGACTA G

(2) INFORMATION FOR SEQ ID NO: 2433: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2881 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2433:

1 ATGAGTGTCA GAAGTGTGAA GGGTGCCTGT TCTGAATCCC AGAGCCTCCT CTCCCTCTGT

61 GAGGCTGGCA GGTGAGGAAG GGTTTAACCT CACTGGAAGG AATCCCTGGA GCTAGCGGCT

121 GCTGAAGGCG TCGAGGTGTG GGGGCACTTG GACAGAACAG TCAGGCAGCC GGGAGCTCTG

181 CCAGCTTTGG TGACCTTGGG CCGGGCTGGG AGCGCTGCGG CGGGAGCCGG AGGACTATGA

241 GCTGCCGCGC GTTGTCCAGA GCCCAGCCCA GCCCTACGCG CGCGGCCCGG AGCTCTGTTC

301 CCTGGAACTT TGGGCACTGC CTCTGGGACC CCTGCCGGCC AGCAGGCAGG ATGGTGCTTG

361 CCTCGTGCCC CTTGGTGCCC GTCTGCTGAT GTGCCCAGCC TGTGCCCGCC ATGCCGCCCT

421 CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG

481 TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA

541 CCTTCTGCTT CATCGTGTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC

601 CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG

661 CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG

721 ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG

781 CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT

841 TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG

901 AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA

961 ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT

1021 TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA

1081 AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCCTCTTTG

1141 CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC

1201 ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA

1261 ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA

1321 ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC

1381 CTGATGACTA GACCCCGCCT TCCGCTCCCA CCAGCCCACA TCCAGTGGGG TCTCAGTCCA

1441 GTCCTCACAT GCCCGCTGTC CCAGGGGTCT CCCTGAGCCT GCCCCAGCTG GGCTGTTGGC

1501 TGGGGGCATG GGGGAGGCTC TGAAGAGATA CCCACAGAGT GTGGTCCCTC CACTAGGAGT

1561 TAACTACCCT ACACCTCTGG GCCCTGCAGG AGGCCTGGGA GGGCAAGGGT CCTACGGAGG

1621 GACCAGGTGT CTAGAGGCAA CAGTGTTCTG AGCCCCCACC TGCCTGACCA TCCCATGAGC

1681 AGTCCAGCGC TTCAGGGCTG GGCAGGTCCT GGGGAGGCTG AGACTGCAGA GGAGCCACCT

1741 GGGCTGGGAG AAGGTGCTTG GGCTTCTGCG GTGAGGCAGG GGAGTCTGCT TGTCTTAGAT

1801 GTTGGTGGTG CAGCCCCAGG ACCAAGCTTA AGGAGAGGAG AGCATCTGCT CTGAGACGGA

1861 TGGAAGGAGA GAGGTTGAGG ATGCACTGGC CTGTTCTGTA GGAGAGACTG GCCAGAGGCA

1921 GCTAAGGGGC AGGAATCAAG GAGCCTCCGT TCCCACCTCT GAGGACTCTG GACCCCAGGC

1981 CATACCAGGT GCTAGGGTGC CTGCTCTCCT TGCCCTGGGC CAGCCCAGGA TTGTACGTGG

2041 GAGAGGCAGA AAGGGTAGGT TCAGTAATCA TTTCTGATGA TTTGCTGGAG TGCTGGCTCC

2101 ACGCCCTGGG GAGTGAGCTT GGTGCGGTAG GTGCTGGCCT CAAACAGCCA CGAGGTGGTA

2161 GCTCTGAGCC CTCCTTCTTG CCCTGAGCTT TCCGGGGAGG AGCCTGGAGT GTAATTACCT

2221 GTCATCTGGG CCACCAGCTC CACTGGCCCC CGTTGCCGGG CCTGGACTGT CCTAGGTGAC

2281 CCCATCTCTG CTGCTTCTGG GCCTGATGGA GAGGAGAACA CTAGACATGC CAACTCGGGA

2341 GCATTCTGCC TGCCTGGGAA CGGGGTGGAC GAGGGAGTGT CTGTAAGGAC TCAGTGTTGA

2401 CTGTAGGCGC CCCTGGGGTG GGTTTAGCAG GCTGCAGCAG GCAGAGGAGG AGTACCCCCC

2461 TGAGAGCATG TGGGGGAAGG CCTTGCTGTC ATGTGAATCC CTCAATACCC CTAGTATCTG

2521 GCTGGGTTTT CAGGGGCTTT GGAAGCTCTG TTGCAGGTGT CCGGGGGTCT AGGACTTTAG

2581 GGATCTGGGA TCTGGGGAAG GACCAACCCA TGCCCTGCCA AGCCTGGAGC CCCTGTGTTG

26 1 GGGGGCAAGG TGGGGGAGCC TGGAGCCCCT GTGTGGGAGG GCGAGGCGGG GGAGCCTGGA

2701 GCCCCTGTGT GGGAGGGCGA GGCGGGGGAT CCTGGAGCCC CTGTGTCGGG GGGCGAGGGA

2761 GGGGAGGTGG CCGTCGGTTG ACCTTCTGAA CATGAGTGTC AACTCCAGGA CTTGCTTCCA

2821 AGCCCTTCCC TCTGTTGGAA ATTGGGTGTG CCCTGGCTCC CAAGGGAGGC CCATGTGACT

2881 AATAAAAAAC TGTGAACCCT

(2) INFORMATION FOR SEQ ID NO:2434: (l) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1921 base pairs EPI-109 582

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2434:

1 CGCATTTGTG TTTTAATAAA AGAATCTGGA AGATAAATAG TCTTGAAGAG AGACAAAGGA

61 AGGAAAATTT AAATCCTTAG ATTCAAGCAG AAGAATTCCA TGTGGAAGGT TTGGGTTGTT

121 GTTGTTGTTG TTTGGTGTGT TTTTTGTTTT TTTGTTTTTT TGTTTTTTTT TGAGATGGAG

181 TCTCGCTGTG TTACCGGGAG CGACAGAGCC GCACGGCCGA GTCGAGTCCC AGCCAGCTAC

2 1 CATCCCTCTG GAGCTTACCG GCCGGCCTTG GCTTCCCCAG GAATCCCTGG AGCTAGCGGC

301 TGCTGAAGGC GTCGAGGTGT GGGGGCACTT GGACAGAACA GTCAGGCAGC CGGGAGCTCT

361 GCCAGCTTTG GTGACCTTGG GTGCTTGCCT CGTGCCCCTT GGTGCCCGTC TGCTGATGTG

421 CCCAGCCTGT GCCCGCCATG CCGCCCTCCA TCTCAGCTTT CCAGGCCGCC TACATCGGCA

481 TCGAGGTGCT CATCGCCCTG GTCTCTGTGC CCGGGAACGT GCTGGTGATC TGGGCGGTGA

541 AGGTGAACCA GGCGCTGCGG GATGCCACCT TCTGCTTCAT CGTGTCGCTG GCGGTGGCTG

601 ATGTGGCCGT GGGTGCCCTG GTCATCCCCC TCGCCATCCT CATCAACATT GGGCCACAGA

661 CCTACTTCCA CACCTGCCTC ATGGTTGCCT GTCCGGTCCT CATCCTCACC CAGAGCTCCA

721 TCCTGGCCCT GCTGGCAATT GCTGTGGACC GCTACCTCCG GGTCAAGATC CCTCTCCGGT

781 ACAAGATGGT GGTGACCCCC CGGAGGGCGG CGGTGGCCAT AGCCGGCTGC TGGATCCTCT

841 CCTTCGTGGT GGGACTGACC CCTATGTTTG GCTGGAACAA TCTGAGTGCG GTGGAGCGGG

901 CCTGGGCAGC CAACGGCAGC ATGGGGGAGC CCGTGATCAA GTGCGAGTTC GAGAAGGTCA

961 TCAGCATGGA GTACATGGTC TACTTCAACT TCTTTGTGTG GGTGCTGCCC CCGCTTCTCC

1021 TCATGGTCCT CATCTACCTG GAGGTCTTCT ACCTAATCCG CAAGCAGCTC AACAAGAAGG

1081 TGTCGGCCTC CTCCGGCGAC CCGCAGAAGT ACTATGGGAA GGAGCTGAAG ATCGCCAAGT

1141 CGCTGGCCCT CATCCTCTTC CTCTTTGCCC TCAGCTGGCT GCCTTTGCAC ATCCTCAACT

1201 GCATCACCCT CTTCTGCCCG TCCTGCCACA AGCCCAGCAT CCTTACCTAC ATTGCCATCT

1261 TCCTCACGCA CGGCAACTCG GCCATGAACC CCATTGTCTA TGCCTTCCGC ATCCAGAAGT

1321 TCCGCGTCAC CTTCCTTAAG ATTTGGAATG ACCATTTCCG CTGCCAGCCT GCACCTCCCA

1381 TTGACGAGGA TCTCCCAGAA GAGAGGCCTG ATGACTAGAC CCCGCCTTCC GCTCCCACCG

1441 CCCACATCCA GTGGGGTCTC AGTCCAGTCC TCACATGCCC GCTGTCCCAG GGGTCTCCCT

1501 GAGCCTGCCC CAGCTGGGCT GTTGGCTGGG GGCATGGGGG AGGCTCTGAA GAGATACCCA

1561 CAGAGTGTGG TCCCTCCACT AGGAGTTAAC TACCCTACAC CTCTGGGCCC TGCAGGAGGC

1621 CTGGGAGGGC AAGGGTCCTA CGGAGGGACC AGGTGTCTAG AGGCAACAGT GTTCTGAGCC

1681 CCCACCTGCC TGACCATCCC ATGAGCAGTC CAGAGCTTCA GGGCTGGGCA GGTCCTGGGG

1741 AGGCTGAGAC TGCAGAGGAG CCACCTGGGC TGGGAGAAGG TGCTTGGGCT TCTGCGGTGA

1801 GGCAGGGGAG TCTGCTTGTC TTAGATGTTG GTGGTGCAGC CCCAGGACCA AGCTTAAGGA

1861 GAGGAGAGCA TCTGCTCTGA GACGGATGGA AGGAGAGAGG TTGAGGATGC ACTGGCCTGT

1921 TCTGTAGGAG AGACTGGCCA GA

(2) INFORMATION FOR SEQ ID NO:2435: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1681 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2435:

1 CCCAGCCCCG AGGCTCAGAA GCGGCAGGCG GAGGCGCGGT CCGGGCGCTA TGGCCATGCC

61 CGGCGGGTCT CACGCGGCTG CCCCTCGCCC GGCGCGCCTT CGGTAGGGGG CGCCCGGGGC

121 CCAGCTGGCC CGGCCATGCT GCTGGAGACA CAGGACGCGC TGTACGTGGC GCTGGAGCTG

181 GTCATCGCCG CGCTTTCGGT GGCGGGCAAC GTGCTGGTGT GCGCCGCGGT GGGCACGGCG

241 AACACTCTGC AGACGCCCAC CAACTACTTC CTGGTGTCCC TGGCTGCGGC CGACGTGGCC

301 GTGGGGCTCT TCGCCATCCC CTTTGCCATC ACCATCAGCC TGGGCTTCTG CACTGACTTC

361 TACGGCTGCC TCTTCCTCGC CTGCTTCGTG CTGGTGCTCA CGCAGAGCTC CATCTTCAGC

421 CTTCTGGCCG TGGCAGTCGA CAGATACCTG GCCATCTGTG TCCCGCTCAG GTATAAAAGT

481 TTGGTCACGG GGACCCGAGC AAGAGGGGTC ATTGCTGTCC TCTGGGTCCT TGCCTTTGGC

541 ATCGGATTGA CTCCATTCCT GGGGTGGAAC AGTAAAGACA GTGCCACCAA CAACTGCACA

601 GAACCCTGGG ATGGAACCAC GAATGAAAGC TGCTGCCTTG TGAAGTGTCT CTTTGAGAAT

661 GTGGTCCCCA TGAGCTACAT GGTATATTTC AATTTCTTTG GGTGTGTTCT GCCCCCACTG

721 CTTATAATGC TGGTGATCTA CATTAAGATC TTCCTGGTGG CCTGCAGGCA GCTTCAGCGC

781 ACTGAGCTGA TGGACCACTC GAGGACCACC CTCCAGCGGG AGATCCATGC AGCCAAGTCA

841 CTGGCCATGA TTGTGGGGAT TTTTGCCCTG TGCTGGTTAC CTGTGCATGC TGTTAACTGT

901 GTCACTCTTT TCCAGCCAGC TCAGGGTAAA AATAAGCCCA AGTGGGCAAT GAATATGGCC

961 ATTCTTCTGT CACATGCCAA TTCAGTTGTC AATCCCATTG TCTATGCTTA CCGGAACCGA

1021 GACTTCCGCT ACACTTTTCA CAAAATTATC TCCAGGTATC TTCTCTGCCA AGCAGATGTC

1081 AAGAGTGGGA ATGGTCAGGC TGGGGTACAG CCTGCTCTCG GTGTGGGCCT ATGATCTAGG

1141 CTCTCGCCTC TTCCAGGAGA AGATACAAAT CCACAAGAAA CAAAGAGGAC ACGGCTGGTT

1201 TTCATTGTGA AAGATAGCTA CACCTCACAA GGAAATGGAC TGCCTCTCTT GAGCACTTCC

1261 CTGGAGCTAC CACGTATCTA GCTAATATGT ATGTGTCAGT AGTAGCACCA AGGATTGACA

1321 AATATATTTA TGATCTATTC AGCTGCTTTT ACTGTGTGGA TTATGCCAAC AGCTTGAATG

1381 GATTCTAACA GACTCTTTTG TTTTTAAAAG TCTGCCTTGT TTATGGTGGA AAATTACTGA EPI-109 583

1441 AACTATTTTA CTGTGAAACA GTGTGAACTA TTATAATGCA AATACTTTTT AACTTAGAGG 1501 CAATGGAAAA ATAAAAGTTG ACTGTACTAA AAATGTATAC TTGTTGCCAG GAAGGTGACC 1561 TCAAAAATTA AAAGTATAAT TATTCGGCCG GGCATGGTGG CTCACACCTG TAATTCCAGC 1621 ACTTTGGGAG GCCAAGGCAG GCGGATCACG AGGTCAGGAG TTCAAAACCA GCCTGTCCAA 1681 TATAGTG

(2) INFORMATION FOR SEQ ID NO:2436: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1681 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2436:

1 GGGCAATTTG TTAGTTATCC GCCGCCACCA AGACGCGGCA CGGCGCCTGG ACCGGAGGGG

61 CCCCGCGCGG GCGCGAACTT TGGGCTCGGG CGAGTGGGTG GTGCTCCGCC CAGCCCGAGA

121 CGGGCGGGCG CGCGGGCCAA TGGGTGCCGC CTCTTGGCCG CGGGGGGCCC CGACCCGTGG

181 GTCCCGGCCA CCAGCGCCCC AGCCCCGAGG CTCAGAAGCG GCAGGCGGAG GCGCGGTCCG

241 GGCGCTATGG CCATGCCCGG CGGGTCTCAC GCGGCTGCCC CTCGCCCGGC GCGCCTTCGG

301 TAGGGGGCGC CCGGGGCCCA GCTGGCCCGG CCATGCTGCT GGAGACACAG GACGCGCTGT

361 ACGTGGCGCT GGAGCTGGTC ATCGCCGCGC TTTCGGTGGC GGGCAACGTG CTGGTGTGCG

421 CCGCGGTGGG CACGGCGAAC ACTCTGCAGA CGCCCACCAA CTACTTCCTG GTGTCCCTGG

481 CTGCGGCCGA CGTGGCCGTG GGGCTCTTCG CCATCCCCTT TGCCATCACC ATCAGCCTGG

541 GCTTCTGCAC TGACTTCTAC GGCTGCCTCT TCCTCGCCTG CTTCGTGCTG GTGCTCACGC

601 AGAGCTCCAT CTTCAGCCTT CTGGCCGTGG CAGTCGACAG ATACCTGGCC ATCTGTGTCC

661 CGCTCAGGTA TAAAAGTTTG GTCACGGGGA CCCGAGCAAG AGGGGTCATT GCTGTCCTCT

721 GGGTCCTTGC CTTTGGCATC GGATTGACTC CATTCCTGGG GTGGAACAGT AAAGACAGTG

781 CCACCAACAA CTGCACAGAA CCCTGGGATG GAACCACGAA TGAAAGCTGC TGCCTTGTGA

8 1 AGTGTCTCTT TGAGAATGTG GTCCCCATGA GCTACATGGT ATATTTCAAT TTCTTTGGGT

901 GTGTTCTGCC CCCACTGCTT ATAATGCTGG TGATCTACAT TAAGATCTTC CTGGTGGCCT

961 GCAGGCAGCT TCAGCGCACT GAGCTGATGG ACCACTCGAG GACCACCCTC CAGCGGGAGA

1021 TCCATGCAGC CAAGTCACTG GCCATGATTG TGGGGATTTT TGCCCTGTGC TGGTTACCTG

1081 TGCATGCTGT TAACTGTGTC ACTCTTTTCC AGCCAGCTCA GGGTAAAAAT AAGCCCAAGT

1141 GGGCAATGAA TATGGCCATT CTTCTGTCAC ATGCCAATTC AGTTGTCAAT CCCATTGTCT

1201 ATGCTTACCG GAACCGAGAC TTCCGCTACA CTTTTCACAA AATTATCTCC AGGTATCTTC

1261 TCTGCCAAGC AGATGTCAAG AGTGGGAATG GTCAGGCTGG GGTACAGCCT GCTCTCGGTG

1321 TGGGCCTATG ATCTAGGCTC TCGCCTCTTC CAGGAGAAGA TACAAATCCA CAAGAAACAA

1381 AGAGGACACG GCTGGTTTTC ATTGTGAAAG ATAGCTACAC CTCACAAGGA AATGGACTGC

1441 CTCTCTTGAG CACTTCCCTG GAGCTACCAC GTATCTAGCT AATATGTATG TGTCAGTAGT

1501 AGGCTCCAAG GATTGACAAA TATATTTATG ATCTATTCAG CTGCTTTTAC TGTGTGGATT

1561 ATGCCAACAG CTTGAATGGA TTCTAACAGA CTCTTTTGTT TTTAAAAGTC TGCCTTGTTT

1621 ATGGTGGAAA ATTACTGAAA CTATTTTACT GTGAAACAGT GTGAACTATT ATAATGCAAA

1681 TACTTTTTAA CTTAGAGGCA ATGGAAAAAT AAAAGTTGAC TGTACTAAAA ATG

(2) INFORMATION FOR SEQ ID NO: 2437: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2461 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2437:

1 GAATTCCCAG ATGGGCAGAG GTGGCTGGGC TGGTGACCCT AAGTGTGTCT CCTGCCTTTA 61 TTCTCTCTAG TGGGTTATTC TTTCATGTGG TATCTTGCCT ACAGCATGCT GTGTTTGGAC 121 ACAAACCCCT TTCCTTGGTT TCTCTGACCC AGCTGAGATG GACTGATTCC AAAAGAACTC 181 ACCTATGTAC TGGGGTAGGG GAGGGAGGGT TTTTTGCAGT ATTTAACTAA GGTTCAAAGA 241 GTGCTATATA GTGAGAAAGG CTTCTTTTTT XTTTTTTTTT TTTTTTGGCA GAGTGCTGCC 301 TCCTAGAAAT TTCTCTTGGT AACTTCCTTC TCTGAAGCAC AGATAAAGAA AACAATTACA 361 GTAGAAACAT TTATGAGGGA CACATTGGAG GCCGATGAAG CTTTTCAAGT TCCAGCAGTG 421 CAGGGATGTG GGCAGAACTG ACATTGGAAA ATACTAGAAT GATGGAAATT CAGTTGGAGA 481 GGACTGCCCT TTTTAATGTC TGGGGAGTCT GCTCAGGGAG AAATGACAAG TCTGGCGGGG 5 1 ACAAGTATGG GATTTGGTAA GACTTGGATC AACTTGGGAT ACAGGGTGGG GGTCGGGAGT 601 GGAATCAATG AATGATGCCA GAGCAGATCA ACTAACAAGA GGACCCTGAT GAGCCCCAGG 661 CAGAGGCGTC TCCCTTATGC CCCACTCTGA AGTGTTTGTT AGTAAACACC AGAACGCCAT 721 TGTTGTTACT GCTGAATTTT ATTTTGGGCT GTACATATTT AGATGCTTAA GGTAAAAATG 781 ATAAAGCCCT CAAGCCACTG TGTGGGTTTG GGTCCAAGTG TTCCTTCTTG CTGCCTCTCT 841 AACACGCCTG GTTAAAATAA TCCCTTTGGA TGGTGCTGAG AAGCACCTGA ACCAAGTGGG 901 TCCCCAAATA ACAATGGCGT GCAAGTGTCT GGTTCCCAGA AGTTGGTGAC TAGGTAAGCA 961 GCTTCAGGGA GAGGGGGCTG ATTCCCAGAC AGTCGCCTGT TCCTGCGGGG ATGGGGCTGA 1021 GGCTTGGGGA ATGTGGGCAG GAGGATATGC CATTTGATTC TGTTGCACAC GTTCTTTTCC 1081 CTTCTTTCTG TATGTCTGGT CATTCTGCTA TTCTGTCGTT CCTCACATAG GTTGGACATT EPI-109 584

1141 GGCCGGCTGC CAGCATAAGT GCCAGTGTGA TTTTGCTAGG TGTGAGCTGA GAAAGAGAGG 1201 TGGAGGCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG TTTTTGCCCT TCTGAGCAGG 1261 GAATCTTTGC TTATCCCTTT GACCAAGGAT CTTTGCTGCA AAGGCTGGGT ATCGGCTGTG 1321 CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGGTTAGGA 1381 GGCTGCCACC AAAGTCTCTT TTTTGTTCCT CTGCTTCTCC CGTTTGCCTC CTTATCATGA 1441 GATCTTTTTG CTAAGCTGGC AGAAAGATTG CATAGTCAGT GCTTCCAGCT CTGCTCCCAC 1501 CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC 1561 GAGCCTTCTC TATGCCACTC ATGGCTCCTC TTCTGCTCTT TCCATCTTTT TGCTGAGAGT 1621 TCTGAGCTCT GTACTTCCTC TTGGCCCATC TCACTTCCTG AAACACCCCT GAAGAGGGTT 1681 GCTTATCTTG ATGGAACTCA AAAAGCCAAA AAGCTGCAGG CAGAGGCGTT GAGGACATCT 1741 GTTTGGGGAA CTAAGAGCAG CAGCACTTTC AGATTCAGTC CATATAGAGC TGTCCTACAG 1801 CATTCTGGAA ACTTGAGGAT GTGCGGTGCA TAAAGGGGCT GGAAGTGACC CACCTGTGAT 1861 GAGCCCTTTC TAAGGAGAAG GGTTTCCAAG AGATCACCCC ACCAGAAAAG GGTAGGAATG 1921 AGCAAGTTGG GAATTTTAGA CTGTCACTGC ACATGGACCT CTGGGAAGAC GTCTGGCGAG 1981 AGCTAGGCCC ACTGGCCCTA CAGACGGATC TTGCTGGCTC ACCTGTCCCT GTGGAGGTTC 2041 CCCTGGGAAG GCAAGATGCC CAACAACAGC ACTGCTCTGT CATTGGCCAA TGTTACCTAC 2101 ATCACCATGG AAATTTTCAT TGGACTCTGC GCCATAGTGG GCAACGTGCT GGTCATCTGC 2161 GTGGTCAAGC TGAACCCCAG CCTGCAGACC ACCACCTTCT ATTTCATTGT CTCTCTAGCC 2221 CTGGCTGACA TTGCTGTTGG GGTGCTGGTC ATGCCTTTGG CCATTGTTGT CAGCCTGGGC 2281 ATCACAATCC ACTTCTACAG CTGCCTTTTT ATGACTTGCC TACTGCTTAT CTTTACCCAC 2341 GCCTCCATCA TGTCCTTGCT GGCCATCGCT GTGGACCGAT ACTTGCGGGT CAAGCTTACC 2401 GTCAGGTAGC CTGCGGCGTG GGGTGGGCAG CAATTGAGGC AGCTGGGAAA TGAGGCTACA 2461 AAGCCAGAGC

(2) INFORMATION FOR SEQ ID NO: 2438: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1321 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2438:

1 CTGCTGAATT TTATTTTGGA CTGTACATAT TTAGATGCTT AAGGTAAAAA TGATAAAGCC

61 CTCAAGCCAC TGTGTGGGTT GGGTCCAAGT GTTCCTTGCT GCTGCCTCTC TAACACGCCT

121 GGTTAAAATA ATCCCTTTGG ATGGTGCTGA GAAGCACCTG AACCAAGTGG GTCCCCAAAT

181 AACTATGGCG TGCAAGTGTC TGGTTCCCAG AAGTTGGTGA CTAGGTAAGC GACTCAGGGA

241 GAGGGGCTGA TTCCCAGACA GTCGCCTGTT CCTGCTGGGA TGGGGCTGAG GCTTGGGGAA

301 TGTGGGCAGG AGGATATGCC ATTTGATTCT GTTGCACACG TTCTTTTCCC TTCTTTCTGT

361 ATGTCTGGTC ATTCTGCTAT TCTGTCGTTC CTCACATAGG TTGGACATTG GCCGGCTGCC

421 AGCATAAGTG CCAGTGTGAT TTTGCTAGGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA

481 GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG TTTTTGCCCT TCTGAGCAGG GAATCTTTGC

541 TTATCCCTTT GACCAAGGAT CTTTGCTCCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG

601 CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGGTTAGGA GGCTGCCACC

661 AAAGTCTCTT TTTTGTTCCT CTGCTTCTCC CGTTTGCCTC CTTATCATGA GATCTTTTTG

721 CTAAGCTGGC AGAAAGATTG CATAATCAGT GCTTCCAGCT CCGCTCCCAC CTGATCCTGC

781 ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC GAGCCTTCTC

841 TATGCCACTC ATGGCTCCTC TTCTGCTCTT TCCATCTTTT TGCTGAGAGT TACTGAGCTC

901 TGTACTTCCT CTTGGCCCAT CTCACTTCCT GAAACACCCC TGAAGAGGGT TGCTTATCTT

961 GATGGAACTC AAAAAGCCAA AAAGCTGCAG GCAGAGGCGT TGAGGACATC TGTTTGGGGA

1021 ACTAAGAGCA GCAGCACTTT CAGATTCAGT CCATATAGAG CTGTCCTACA GCATTCTGGA

1081 AACTTGAGGA TGTGCGGTGC ATAAAGGGGC TGGAAGTGAC CCACCTGTGA TGAGCCCTTT

1141 CTAAGGAGAA GGGTTTCCAA GAGATCACCC CACCAGAAAA GGGTAGGAAT GAGCAAGTTG

1201 GGAATTTTAG ACTGTCACTG CACATGGACC TCTGGGAAGA CGTCTGGCGA GAGCTAGGCC

1261 CACTGGCCCT ACAGACGGAT CTTGCTGGCT CACCTGTCCC TGTGGAGGTT CCCCTGGGAA

1321 GGCAAGATGC CCAACAACAG CACTGCTCTG

(2) INFORMATION FOR SEQ ID NO:2439: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1741 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2439:

1 CGAATTCGGG GGACATCTGT TTGGGGAACT AAGAGCAGCA GCACTTTCAG ATTCAGTCCA 61 TATAGAGCTG TCCTACAGCA TTCTGGAAAC TTGAGGATGT GCGGTGCATA AACGGGCTGG 121 AAGTGACCCA CCTGTGATGA GCCCTTTCTA AGGAGAAGGG TTTCCAAGAG ATCACCCCAC 181 CAGAAAAGGG TAGGAATGAG CAAGTTGGGA ATTTTAGACT GTCACTGCAC ATGGACCTCT 241 GGGAAGACGT CTGGCGAGAG CTAGGCCCAC TGGCCCTACA GACGGATCTT GCTGGCTCAC 301 CTGTCCCTGT GGAGGTTCCC CTGGGAAGGC AAGATGCCCA ACAACAGCAC TGCTCTGTCA 361 TTGGCCAATG TTACCTACAT CACCATGGAA ATTTTCATTG GACTCTGCGC CATAGTGGGC EPI-109 585

421 AACGTGCTGG TCATCTGCGT GGTCAAGCTG AACCCCAGCC TGCAGACCAC CACCTTCTAT

481 TTCATTGTCT CTCTAGCCCT GGCTGACATT GCTGTTGGGG TGCTGGTCAT GCCTTTGGCC

541 ATTGTTGTCA GCCTGGGCAT CACAATCCAC TTCTACAGCT GCCTTTTTAT GACTTGCCTA

601 CTGCTTATCT TTACCCACGC CTCCATCATG TCCTTGCTGG CCATCGCTGT GGACCGATAC

661 TTGCGGGTCA AGCTTACCGT CAGATACAAG AGGGTCACCA CTCACAGAAG AATATGGCTG

721 GCCCTGGGCC TTTGCTGGCT GGTGTCATTC CTGGTGGGAT TGACCCCCAT GTTTGGCTGG

781 AACATGAAAC TGACCTCAGA GTACCACAGA AATGTCACCT TCCTTTCATG CCAATTTGTT

841 TCCGTCATGA GGATGGACTA CATGGTATAC TTCAGCTTCC TCACCTGGAT TTTCATCCCC

901 CTGGTTGTCA TGTGCGCCAT CTATCTTGAC ATCTTTTACA TCATTCGGAA CAAACTCAGT

961 CTGAACTTAT CTAACTCCAA AGAGACAGGT GCATTTTATG GACGGGAGTT CAAGACGGCT

1021 AAGTCCTTGT TTCTGGTTCT TTTCTTGTTT GCTCTGTCAT GGCTGCCTTT ATCTCTCATC

1081 AACTGCATCA TCTACTTTAA TGGTGAGGTA CCACAGCTTG TGCTGTACAT GGGCATCCTG

1141 CTGTCCCATG CCAACTCCAT GATGAACCCT ATCGTCTATG CCTATAAAAT AAAGAAGTTC

1201 AAGGAAACCT ACCTTTTGAT CCTCAAAGCC TGTGTGGTCT GCCATCCCTC TGATTCTTTG

1261 GACACAAGCA TTGAGAAGAA TTCTGAGTAG TTATCCATCA GAGATGACTC TGTCTCATTG

1321 ACCTTCAGAT TCCCCATCAA CAAACACTTG AGGGCCTGTA TGCCTGGGCC AAGGGATTTT

1381 TACATCCTTG ATTACTTCCA CTGAGGTGGG AGCATCTCCA GTGCTCCCCA ATTATATCTC

1441 CCCCACTCCA CTACTCTCTT CCTCCACTTC ATTTTTCCTT TGTCCTTTCT CTCTAATTCA

1501 GTGTTTTGGA GGCCTGACTT GGGGACAACG TATTATTGAT ATTATTGTCT GTTTTCCTTC

1561 TTCCCAATAG AAGAATAAGT CATGGAGCCT GAAGGGTGCC TAGTTGACTT ACTGACAAAA

1621 GGCTCTAGTT GGGCTGAACA TGTGTGTGGT GGTGACTCAT TTCCATGCCA TTGTGGAATT

1681 GAGCAGAGAA CCTGCTCTCG GAGGATGCCT AGGAGATGTT GGGAACAGAA GAAATAAACT

1741 GAGTTTAAGG GGGACTTAAA CTGCTGAATT C

(2) INFORMATION FOR SEQ ID NO: 2440: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2041 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2440:

1 GCCGCCGCCG CCAAGATGGC GGACCTGGAG GCGGTGCTGG CCGACGTGAG CTACCTGATG

61 GCCATGGAGA AGAGCAAGGC CACGCCGGCC GCGCGCGCCA GCAAGAAGAT ACTGCTGCCC

121 GAGCCCAGCA TCCGCAGTGT CATGCAGAAG TACCTGGAGG ACCGGGGCGA GGTGACCTTT

181 GAGAAGATCT TTTCCCAGAA GCTGGGGTAC CTGCTCTTCC GAGACTTCTG CCTGAACCAC

241 CTGGAGGAGG CCAGGCCCTT GGTGGAATTC TATGAGGAGA TCAAGAAGTA CGAGAAGCTG

301 GAGACGGAGG AGGAGCGTGT GGCCCGCAGC CGGGAGATCT TCGACTCATA CATCATGAAG

361 GAGCTGCTGG CCTGCTCGCA TCCCTTCTCG AAGAGTGCCA CTGAGCATGT CCAAGGCCAC

421 CTGGGGAAGA AGCAGGTGCC TCCGGATCTC TTCCAGCCAT ACATCGAAGA GATTTGTCAA

481 AACCTCCGAG GGGACGTGTT CCAGAAATTC ATTGAGAGCG ATAAGTTCAC ACGGTTTTGC

541 CAGTGGAAGA ATGTGGAGCT CAACATCCAC CTGACCATGA ATGACTTCAG CGTGCATCGC

601 ATCATTGGGC GCGGGGGCTT TGGCGAGGTC TATGGGTGCC GGAAGGCTGA CACAGGCAAG

661 ATGTACGCCA TGAAGTGCCT GGACAAAAAG CGCATCAAGA TGAAGCAGGG GGAGACCCTG

721 GCCCTGAACG AGCGCATCAT GCTCTCGCTC GTCAGCACTG GGGACTGCCC ATTCATTGTC

781 TGCATGTCAT ACGCGTTCCA CACGCCAGAC AAGCTCAGCT TCATCCTGGA CCTCATGAAC

841 GGTGGGGACC TGCACTACCA CCTCTCCCAG CACGGGGTCT TCTCAGAGGC TGACATGCGC

901 TTCTATGCGG CCGAGATCAT CCTGGGCCTG GAGCACATGC ACAACCGCTT CGTGGTCTAC

961 CGGGACCTGA AGCCAGCCAA CATCCTTCTG GACGAGCATG GCCACGTGCG GATCTCGGAC

1021 CTGGGCCTGG CCTGTGACTT CTCCAAGAAG AAGCCCCATG CCAGCGTGGG CACCCACGGG

1081 TACATGGCTC CGGAGGTCCT GCAGAAGGGC GTGGCCTACG ACAGCAGTGC CGACTGGTTC

1141 TCTCTGGGGT GCATGCTCTT CAAGTTGCTG CGGGGGCACA GCCCCTTCCG GCAGCACAAG

1201 ACCAAAGACA AGCATGAGAT CGACCGCATG ACGCTGACGA TGGCCGTGGA GCTGCCCGAC

1261 TCCTTCTCCC CTGAACTACG CTCCCTGCTG GAGGGGTTGC TGCAGAGGGA TGTCAACCGG

1321 AGATTGGGCT GCCTGGGCCG AGGGGCTCAG GAGGTGAAAG AGAGCCCCTT TTTCCGCTCC

1381 CTGGACTGGC AGATGGTCTT CTTGCAGAAG TACCCTCCCC CGCTGATCCC CCCACGAGGG

1441 GAGGTGAACG CGGCCGACGC CTTCGACATT GGCTCCTTCG ATGAGGAGGA CACAAAAGGA

1501 ATCAAGTTAC TGGACAGTGA TCAGGAGCTC TACCGCAACT TCCCCCTCAC CATCTCGGAG

1561 CGGTGGCAGC AGGAGGTGGC AGAGACTGTC TTCGACACCA TCAACGCTGA GACAGACCGG

1621 CTGGAGGCTC GCAAGAAAGC CAAGAACAAG CAGCTGGGCC ATGAGGAAGA CTACGCCCTG

1681 GGCAAGGACT GCATCATGCA TGGCTACATG TCCAAGATGG GCAACCCCTT CCTGACCCAG

1741 TGGCAGCGGC GGTACTTCTA CCTGTTCCCC AACCGCCTCG AGTGGCGGGG CGAGGGCGAG

1801 GCCCCGCAGA GCCTGCTGAC CATGGAGGAG ATCCAGTCGG TGGAGGAGAC GCAGATCAAG

1861 GAGCGCAAGT GCCTGCTCCT CAAGATCCGC GGTGGGAAAC AGTTCATTTT GCAGTGCGAT

1921 AGCGACCCTG AGCTGGTGCA GTGGAAGAAG GAGCTGCGCG ACGCCTACCG CGAGGCCCAG

1981 CAGCTGGTGC AGCGGGTGCC CAAGATGAAG AACAAGCCGC GCTCGCCCGT GGTGGAGCTG

2041 AGCAAGGTGC CGCTGGTCCA GCGCGGCAGT GCCAACGGCC TCTGACCCGC CCACCCGCCT

(2) INFORMATION FOR SEQ ID NO:2441: (l) SEQUENCE CHARACTERISTICS: EPI-109 586

(A) LENGTH: 7321 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2441:

1 AAATGATAGA CCGTCAATAA TTTGTTAAAT GCTTTTTAAA ATGAATGCTT TAAGCCGGGT

61 GCAGTGCCTC ACATCTGTAA TCCCAGCACT TTGGAGCCGA GCGGGTGGAT TGTGTGAGGT

121 CAGGAGTTCG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCTCTACC AAAAATACAA

181 AAATTAGCCA GGCATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG

241 GAGAATCGCT TGAACCCGGG AGGCAAGGTT GCAGTGAGCC AAGATTACGC CATTGTACTC

301 CAGCCTGGGT GACAGAGAGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATTAC

361 GCTTCAAACA CATGATCTCT CACCACTGTT GAATTTTCTT TCTATGAGCC CAGGAGGGCC

421 TCTCAGAGAG GAAAGCTCCT AGGTCTTCCT TTCCCTCTGC AAACTCCCTG CCTTGAAGGT

481 TCAGAAGGAC TGTGCGTGCT CGTTGCATCC TTTGCAAGTG TCCAAACCCT GATCCCAGCT

541 GTGCTTAGGG GTTCCTGCAA ACCTTTTCCA GGTGTTAATT ACCTCCCACT TCATTTCCTG

601 TTTACCAACT CAGCTTTTTG TTTTAGTGTG TTTGAATTCC CTGAACTGAC CGTTGTCTGA

661 TCTCCACCTC CCAACTGAAT TAGGGGAGCT GGGCTTCTGG AAACCCAGGT GCCGGGTGTT

721 GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACACACAC

781 ACCCACATAC CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TTGGACATGC

841 ATAGACCACA GCTTTCCACA CCCTTCCTAG ACAGGGGTCA CTTGGTATCC TGGAGAGAGT

901 GTGAAGTCCT GGAATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA

961 CAAGTCACCA CCAACCCATC TGCGCCTTGT TTACCTCCTC TGTGAGGCAA GCACAGAGCC

1021 CATGCCTGCC CCCCTGGATG GGAGTGATGT GAAACTTGAA GGGCGGTCAG AGCAAGGGTC

1081 GGGAATGGAA GGCCCTTGGG AAAAAAGGCC CTTTCAACTA GGGGCACAGA GGAGGCCCTG

1141 GGCTGAGAAC TTGACAGCAC CTTGTAATTG GTAAGCCAAG CCCGAAGGGA CTGGAAATAC

1201 TCAGATGTGT CTGTCTCCCT TATTAGGTTC AAAGTCCCTC AAGACCCTGT CTCCATCACA

1261 GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGACCCAA CCAGCCCTAT

1321 GGGGTCGCAT CCCCACCTGC CTGGAATTCT CCAAAGAACC TCCCCTTTAA CAGTTCCAGC

1381 CTTTAACAGT TCCAGTCTAA ACACATGACC TTTCTCCTCT AAATCAGCCC CCCATCTCTG

1441 CCTTTGCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC CCATCCATGT

1501 CCAATCAAGC ACTAGGCATG TCAGGTTTAC CCTCTAAACT CCTCTGGAAT CCAGTCTCTC

1561 AGTCTCCATC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCTTGCTTC CACTCTACCC

1621 CCACTGCAGT CCTGACTTCC TGAGCAGCAG CCAGGGCCTA ATCGATATTC ACACCAAGCG

1681 CCAACCTGAC TGAGATATCC TCCTGCACCA TCATCCCTCC ACCCTGTTTA GTTCTGCTCA

1741 CCCTCAGTGT TCTCATCAAT AATCCACTCC CCTCACAGGC GCGTTTGGGA CCCCATGTTC

1801 TATGCTCTCA CAGGACCTTT TGCTTGATTT TTCACTGTAC TTAGGTCAGT TTGCAGTTAT

1861 TAAGTGACTG AGCAATGTCT GGCTTCTCCA GTAGACTGTC AGCTCCTAGC CATTGTATAC

1921 CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG AGTCAGGGAC TCAGCAGTCT

1981 CCATTTCTCC GCCCTGCTGG AGAATGCGTG TATTTGGCAA TCCCCAGCCC CTGTGCCATC

2041 TAACCATCTT TTCTTCTCTG TTCAGCCCAG GTGTGGCCTC ACTCACATCC CACTCTGAGT

2101 CCAAATGTTC TCTCCCTGGA AGATATCAAT GTTTCTGTCT GTTCGTGAGG ACTCCGTGCC

2161 CACCACGGCC TCTTTCAGGT GAGTCAAAGG GATTCCTCAG TTCACTAGTT AGGGGAGGTG

2221 GGCAGACACC CTGGAGAACT CCCTGGAAAG CTCAACTCTC ATGCCCCGGA CAACAGTTGA

2281 AGGAACCATG GTGATGTTAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGTTG

2341 GAATCTTGGG AGCAGAGGGA ATGTTCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA

2401 AGGGCACATT CCTGGTTGTT ATATGTTTCT ATCTATCCCA GATGAACTTG GAAGTGAAGG

2461 GAAGAGAGTT AAACATTAAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC

2521 CTTGGAAACA AAATATCTCC AACACATGGC TGACATTTGG TGGGAGATCA GAACACCCTA

2581 AAGAGAGAAT TTAAGGGGAG GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC AGAGGATAGG

2641 GAGATCTGTT CTTGGGGACA GCATTTGCAA GAAACAAGGC TGAGGGGTCC ACTCCAACCT

2701 CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGGCCAT CTCAGCTGGG

2761 GCCACAGTGC ACTGGACCTA TAGTTTCCAA TTCCGCACTC AGCAGGCATC TTTCTGATGA

2821 TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCTTGGCT ACTGTCTTGC

2881 TGAGAAATTT ATAAGCAGCA TCTGGTGCTA TACTTTGGTC TCTAGTGAGT TAGCTCATGA

2941 AAGATGATAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GGTTTTCTGT AGCTACAGAA

3001 ATGGGGTTGA GGGTTGGACC AAGGGACTAC CCAGGGGAAG TCTTACCTTC AGAGGACTCT

3061 GGAAAGGAGG CTGCAAGTTT TCATGGGTCA AGAATTCAGA GCCCAGTAGA GACAGCTTAT

3121 CTCTGTTCCA AGATGTCTGG GGCCTTGGTT GGAAGATTCA AAGGCTAGGA AACCAGGAGC

3181 CACCAAAAGC GTAACTGGGG CCAGAGGATC CACTTTCAAG GTGGCAAGTT GGTTCCCCCC

3241 ATGTGGCTGC TTGAGTATCC TCACATGGCG GCTCACATCC TTCCAAGTAA GCAATGCAAA

3301 AGGCCAAGAA AGATGCTGCA AAGATGTTAT GACCTAGCCT CAGAAATCAC ACACCATCCC

3361 TGCCACCATT AGTAAGAAGT CCAGCCCACG TCCAGGAGAA GAGGAAGCAG ATTCCTCCTT

3421 TTGAAATGAA GAATATCAAG TAATTCGGGG GGCATATGAA AGCCACCACA CACCACAGGG

3481 ATCTTTTTAG AGCATACTTC TTATACCATC ACTGTAGTTC CTTAAGACTC AGGGGCAAAG

3541 CCTCACTTCC TTAGCACCCA GTGAAGACCA CGCTTACTCC CTCACTCAAC CTCTTGCTAC

3601 TTCCCACCTC TCCTGTCCAA CATCTAGTGT CACTTTCCAG AACATACCAA CAGCTTCCCC

3661 AGTTCTGTGC CTCTGCTCAG GCTGTTCCCC CTGCCTGGTC CACTTGTCCT CCTTCTTGTC

3721 CGGTCAAAAT GCTTCTTATC CTTCAAGACC CAGCTCTAGA GTCACCTCCA ACCCCTTACC

3781 CACCAGCCCC CTCTCCAAGT CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC EPI-109 587

3841 CACCCTCTGG GCCACAGTTG TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG GTGTCTTCTT

3901 TGTGTTCTTG CACTCAGGGC AGAGCTCAGC ACAGAGCAGA CGCTCAAAAA ACATTTAAAG 3961 GATAGAAGCA TTGATTTGTG GGTCCCCCAG TCTGGCTCCA GGATGCCAGC CAGCTGCTCC

4021 TAGAAGCAAA CGGACTTTTC CTGGGAAATC CCAGAGGTGA TGATCAGTAA TCTCTCCCGT 4081 GACTCGTAGT TCAGCTCTTC CTCCATGAGC CTGACTATCA GTGGACCTTC CAGAAAGAGC 4141 CCCTTTTCCT TCTCTCACCC ACAGCACAGG GCACTGGGAA AATGCCCAAT GAGTCCTGCC 4201 TCTGGGTTGT GCTTTGGACT TTTCAGTGTG TCTCGCATCC ACTCTTCAAC TTGAATGTTG 4261 CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATTCAGGATG AGAGCAATAC CCTACTCCAA 4321 AGAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAATTTGC CCAAGACCAC ACAGCTAGGA 4381 GTGGAACTCA TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GGTAGAGATG AATTACAGCA 4441 ACAAGTCTAG AAAGGTGCCT GCCCTATGGT CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA 4501 GCCAGTGGGT TAAAGATGAG GTCACCAACA ACGGTGGTGT TGGAGTTTAC CACTGATAAT 4561 AAGGGTGCAA AATGTAAATT ACTAATGTTT ATTGAGCCTA GTGCAGTGCG TGGGGCATTT 4621 TGCACATTGT CTCTGATCCC TATGACAACC CTGAGAGGTA GTGGTTTTAA CTGCCATGTT 4681 ACAGGTGAGG TCATTGTGGT TCAAGGACGT TAAGTAACTT CCCCAGCGTG ACACGGCTTA 4741 TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT GGCTGCAAAG TCCCCACCCC 4801 CCTCGCCATC TGTATCCTCC AATCACTTCA GTGCTTTGCT GCATAGAAGG TAACGGAAAT 4861 CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCTC 4921 CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATT TTTCTCTTTT AATAAATTAA

4981 CTCACCCACC ACACGGCTTT GAGAGGCTCA AAGTTGACCA ACTCCCTTGG GAGGGCCCCG 5041 GTTGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC TTCAAGGAGG TCAAGGGTCC 5101 AACACTTGAG ATTGTTAGTG CTGTTGGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC 5161 CTCGAGATGA AGAACATGAG GCCCCCGTTT AGAACCAAGG ATCAGAGGGG GCTCTGTAAG 5221 ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT 5281 CGGCTTCTCC TTGTCCTGGC TGGTTGTCCT TAACCCCTGT CTCCTTCTGG ACCAGTTTTT 5341 GTCCTTCCCT TGTGACCGCT GAGGGGTAAC AGCCTCTTTC CACTTTCTTT CAGCGCCGAC 5401 ATGCTCAATG TCACCTTGCA AGGGCCCACT CTTAACGGGA CCTTTGCCCA GAGCAAATGC 5461 CCCCAAGTGG AGTGGCTGGG CTGGCTCAAC ACCATCCAGC CCCCCTTCCT CTGGGTGCTG 5521 TTCGTGCTGG CCACCCTAGA GAACATCTTT GTCCTCAGCG TCTTCTGCCT GCACAAGAGC 5581 AGCTGCACGG TGGCAGAGAT CTACCTGGGG AACCTGGCCG CAGCAGACCT GATCCTGGCC

5641 TGCGGGCTGC CCTTCTGGGC CATCACCATC TCCAACAACT TCGACTGGCT CTTTGGGGAG 5701 ACGCTCTGCC GCGTGGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG CATCTGTTTC 5761 CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG 5821 ATGCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTGGGGGTG TACGCTGCTC 5881 CTGAGCTCAC CCATGCTGGT GTTCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC 5941 GTCACCGCTT GTGTCATCAG CTACCCATCC CTCATCTGGG AAGTGTTCAC CAACATGCTC 6001 CTGAATGTCG TGGGCTTCCT GCTGCCCCTG AGTGTCATCA CCTTCTGCAC GATGCAGATC 6061 ATGCAGGTGC TGCGGAACAA CGAGATGCAG AAGTTCAAGG AGATCCAGAC GGAGAGGAGG 6121 GCCACGGTGC TAGTCCTGGT TGTGCTGCTG CTATTCATCA TCTGCTGGCT GCCCTTCCAG 6181 ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGGCATCC TCTCCAGCTG CCAGGACGAG 6241 CGCATCATCG ATGTAATCAC ACAGATCGCC TCCTTCATGG CCTACAGCAA CAGCTGCCTC 6301 AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTTCCGAA AGAAGTCTTG GGAGGTGTAC 6361 CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA TTCAGATGGA GAACTCCATG 6421 GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTGCA GGACTGGGCA 6481 GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA ATTTGTGTAA GGATTGAGGG 6541 ACAGTTGCTT TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG 6601 AAATGAGTTG ATGTCTCCGG TAAAACACCG GAGACTAATT CCTGCCCTGC CCAATTTTGC 6661 AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA 6721 ACAGCATTAC TGTTCTTATT TGCTGCCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGTG 6781 GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA CTGAGCTTCC CTCCCGTGTG TTCTCCGTCC 6841 CTGCCCCAGC AAGACAACTT AGATCTCCAG GAGAACTGCC ATCCAGCTTT GGTGCAATGG 6901 CTGAGTGCAC AAGTGAGTTG TTGCCCTGGG TTTCTTTAAT CTATTCAGCT AGAACTTTGA 6961 AGGACAATTT CTTGCATTAA TAAAGGTTAA GCCCTGAGGG GTCCCTGATA ACAACCTGGA 7021 GACCAGGATT TTATGGCTCC CCTCACTGAT GGACAAGGAG GTCTGTGCCA AAGAAGAATC 7081 CAATAAGCAC ATATTGAGCA CTTGCTGTAT ATGCAGTATT GAGCACTGTA GGCAAGAGGG 7141 AAGAAAGAGA AGGAGCCATC TCCATCTTGA AGGAACTCAA AGACTCAAGT GGGAACGACT 7201 GGGCACTGCC ACCACCAGAA AGCTGTTCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA 7261 TATGGACAGC AGAAGGGGGA GCCAGGTTCC AGCTCACCAA TACTATTGCA CACCACCTGT 7321 CCTGCCTC

(2) INFORMATION FOR SEQ ID NO: 2442: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 241 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2442: 1 GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA 61 GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC EPI-109 588

121 TGAAGTGCCC ATGCCGCTTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC 181 GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC 241 AGCGGGGAGA AGTTTCCCTG TGGTCGTGGG GAGTT

(2) INFORMATION FOR SEQ ID NO: 2443: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1441 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2443:

1 GAGCTCTTCA ATATTTTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA

61 CACACCTTTT CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA

121 CTGGCAAGTC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC

181 AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT

241 TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGTTTCC

301 CTGTCTCCAT GATGATGGGA TCAGGCTTGA TTGCTGGTTT GTAGGCTTGT TATGAATCAA

361 GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTTCC

421 CCAGATCCAC TGGGCCCACT CTTATCTGTT CTCTTCTGAA GGAAGGGTTT TAAGGCTTCA

481 AAAAAAAATG TTTTGAAAGT CCCTGCCCTT TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT

5 1 GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAAAC TGAGAAAGCC AGCCTGAGCC

601 TTGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA

661 GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGCC ACTGTCGCCC TTGGGAGCCG

721 TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTTTA

781 CACCTTCCGC GTAAACGCCC ACTGTTTACA TCCAAAACTC AGACACAAAA TAACCACCTC

841 AAGAAGATAA ATAATGATAA GAAATAAATG TTACGCGAGG CAAATTTATT CACATGGGGC

901 TTCCCAGGCC ACTTTGTGGT CAGCCGGGAG GGACGTTTTT GCCGTCCCAC GACTCCAACG

961 GGCAGCCGGG CCTACGCAAA CATGGAAATC TTCCAAGAGC CTCCCTGGCC CCCAGGGCTC

1021 AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCTT CCCGGCCCCA CAGCCAGCCT

1081 GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG

1141 CTGATGACAT CACTACCCAG CCCTTCAAAG ATGAGCTGTT CCCGCCGCCA CTCCAGCTCT

1201 GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC

1261 CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGAGAAG GTGGGTGCCG

1321 GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG

1381 GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AGTTGGGAAA

14 1 AGTTCCCTTC CTTCCGGAGG GAGG

(2) INFORMATION FOR SEQ ID NO: 2444: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2581 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2444:

1 CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT

61 GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC

121 AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG

181 ACTAATTCCT GCCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA

2 1 CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT

301 GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG

361 AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG

421 AACTGCCATC CAGCTTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT

481 CTTTAATCTA TTCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC

541 CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA

601 CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA TTGAGCACTT GCTGTATATG

661 CAGTATTGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCTTGAAGG

721 AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAAGC TGTTCGACGA

781 GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA

841 GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTT TTATGTAACA

901 TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG

961 TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA

1021 AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC

1081 GGTGTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTT CCACCTGTCA

1141 TTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCATTTGGAG AGAAGGCCAT

1201 GTCTTCAAAG TCTGATTTGT GATGAGGCAG AGGAAGATAT TTCTAATCGG TCTTGCCCAG

1261 AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG

1321 GCCTGCTCAG GGACTGTTCC TGTCTCAGCA ACCAAGGGAT TGTTCCTGTC AATCAATGGT

1381 TTATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGTGT

1441 TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT AAATGAATAT TTATTAGCTG EPI-109 589

1501 GTTGGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA

1561 CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT

1621 AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA

1681 ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA

1741 ACCTAGAAGG GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG

1801 AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGTTA

1861 GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC

1921 TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC

1981 TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATTTACAT

2041 GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAAT TTTAAAGCAA AAGCGTGAAA

2101 AAAAAGATTC CCTCCTTACC CCCAACCCAC TCTTTTTTCC CACCACCCAC TCTCCTCTGC

2161 CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATTTAGTATT

2221 AGTATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC

2281 TGTGTTTTGT CACACAGGGC AGTCATTCAG CACCAGAGCA CGTGATGGTC TGAGACTCTC

2341 TTAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA

2401 CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC

2461 TGTCCTGTGA AAGACTCAAT GAGCTGTTAT GTTGTAAACA GGAAGCATTT CACATCCAAA

2521 CGAGAAAATC ATGTAAACAT GTGTCTTTTC TGTAGAGCAT AATAAATGGA TGAGGTTTTT

2581 GCAAAAAAAA AAAAAAAAA

(2) INFORMATION FOR SEQ ID NO:2445: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 7321 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2445:

1 AAATGATAGA CCGTCAATAA TTTGTTAAAT GCTTTTTAAA ATGAATGCTT TAAGCCGGGT

61 GCAGTGCCTC ACATCTGTAA TCCCAGCACT TTGGAGCCGA GCGGGTGGAT TGTGTGAGGT

121 CAGGAGTTCG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCTCTACC AAAAATACAA

181 AAATTAGCCA GGCATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG

241 GAGAATCGCT TGAACCCGGG AGGCAAGGTT GCAGTGAGCC AAGATTACGC CATTGTACTC

301 CAGCCTGGGT GACAGAGAGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATTAC 361 GCTTCAAACA CATGATCTCT CACCACTGTT GAATTTTCTT TCTATGAGCC CAGGAGGGCC 421 TCTCAGAGAG GAAAGCTCCT AGGTCTTCCT TTCCCTCTGC AAACTCCCTG CCTTGAAGGT

481 TCAGAAGGAC TGTGCGTGCT CGTTGCATCC TTTGCAAGTG TCCAAACCCT GATCCCAGCT 541 GTGCTTAGGG GTTCCTGCAA ACCTTTTCCA GGTGTTAATT ACCTCCCACT TCATTTCCTG 601 TTTACCAACT CAGCTTTTTG TTTTAGTGTG TTTGAATTCC CTGAACTGAC CGTTGTCTGA 661 TCTCCACCTC CCAACTGAAT TAGGGGAGCT GGGCTTCTGG AAACCCAGGT GCCGGGTGTT 721 GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACACACAC 781 ACCCACATAC CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TTGGACATGC 841 ATAGACCACA GCTTTCCACA CCCTTCCTAG ACAGGGGTCA CTTGGTATCC TGGAGAGAGT 901 GTGAAGTCCT GGAATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA 961 CAAGTCACCA CCAACCCATC TGCGCCTTGT TTACCTCCTC TGTGAGGCAA GCACAGAGCC

1021 CATGCCTGCC CCCCTGGATG GGAGTGATGT GAAACTTGAA GGGCGGTCAG AGCAAGGGTC 1081 GGGAATGGAA GGCCCTTGGG AAAAAAGGCC CTTTCAACTA GGGGCACAGA GGAGGCCCTG 1141 GGCTGAGAAC TTGACAGCAC CTTGTAATTG GTAAGCCAAG CCCGAAGGGA CTGGAAATAC 1201 TCAGATGTGT CTGTCTCCCT TATTAGGTTC AAAGTCCCTC AAGACCCTGT CTCCATCACA 1261 GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGACCCAA CCAGCCCTAT 1321 GGGGTCGCAT CCCCACCTGC CTGGAATTCT CCAAAGAACC TCCCCTTTAA CAGTTCCAGC 1381 CTTTAACAGT TCCAGTCTAA ACACATGACC TTTCTCCTCT AAATCAGCCC CCCATCTCTG 1441 CCTTTGCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC CCATCCATGT 1501 CCAATCAAGC ACTAGGCATG TCAGGTTTAC CCTCTAAACT CCTCTGGAAT CCAGTCTCTC 1561 AGTCTCCATC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCTTGCTTC CACTCTACCC 1621 CCACTGCAGT CCTGACTTCC TGAGCAGCAG CCAGGGCCTA ATCGATATTC ACACCAAGCG 1681 CCAACCTGAC TGAGATATCC TCCTGCACCA TCATCCCTCC ACCCTGTTTA GTTCTGCTCA

1741 CCCTCAGTGT TCTCATCAAT AATCCACTCC CCTCACAGGC GCGTTTGGGA CCCCATGTTC 1801 TATGCTCTCA CAGGACCTTT TGCTTGATTT TTCACTGTAC TTAGGTCAGT TTGCAGTTAT

1861 TAAGTGACTG AGCAATGTCT GGCTTCTCCA GTAGACTGTC AGCTCCTAGC CATTGTATAC 1921 CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG AGTCAGGGAC TCAGCAGTCT 1981 CCATTTCTCC GCCCTGCTGG AGAATGCGTG TATTTGGCAA TCCCCAGCCC CTGTGCCATC 2041 TAACCATCTT TTCTTCTCTG TTCAGCCCAG GTGTGGCCTC ACTCACATCC CACTCTGAGT 2101 CCAAATGTTC TCTCCCTGGA AGATATCAAT GTTTCTGTCT GTTCGTGAGG ACTCCGTGCC 2161 CACCACGGCC TCTTTCAGGT GAGTCAAAGG GATTCCTCAG TTCACTAGTT AGGGGAGGTG 2221 GGCAGACACC CTGGAGAACT CCCTGGAAAG CTCAACTCTC ATGCCCCGGA CAACAGTTGA 2281 AGGAACCATG GTGATGTTAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGTTG 2341 GAATCTTGGG AGCAGAGGGA ATGTTCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA 2401 AGGGCACATT CCTGGTTGTT ATATGTTTCT ATCTATCCCA GATGAACTTG GAAGTGAAGG 2461 GAAGAGAGTT AAACATTAAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC EPI-109 590

2521 CTTGGAAACA AAATATCTCC AACACATGGC TGACATTTGG TGGGAGATCA GAACACCCTA 2581 AAGAGAGAAT TTAAGGGGAG GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC AGAGGATAGG

2641 GAGATCTGTT CTTGGGGACA GCATTTGCAA GAAACAAGGC TGAGGGGTCC ACTCCAACCT 2701 CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGGCCAT CTCAGCTGGG 2761 GCCACAGTGC ACTGGACCTA TAGTTTCCAA TTCCGCACTC AGCAGGCATC TTTCTGATGA 2821 TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCTTGGCT ACTGTCTTGC 2881 TGAGAAATTT ATAAGCAGCA TCTGGTGCTA TACTTTGGTC TCTAGTGAGT TAGCTCATGA 2941 AAGATGATAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GGTTTTCTGT AGCTACAGAA 3001 ATGGGGTTGA GGGTTGGACC AAGGGACTAC CCAGGGGAAG TCTTACCTTC AGAGGACTCT 3061 GGAAAGGAGG CTGCAAGTTT TCATGGGTCA AGAATTCAGA GCCCAGTAGA GACAGCTTAT 3121 CTCTGTTCCA AGATGTCTGG GGCCTTGGTT GGAAGATTCA AAGGCTAGGA AACCAGGAGC 3181 CACCAAAAGC GTAACTGGGG CCAGAGGATC CACTTTCAAG GTGGCAAGTT GGTTCCCCCC 3241 ATGTGGCTGC TTGAGTATCC TCACATGGCG GCTCACATCC TTCCAAGTAA GCAATGCAAA 3301 AGGCCAAGAA AGATGCTGCA AAGATGTTAT GACCTAGCCT CAGAAATCAC ACACCATCCC 3361 TGCCACCATT AGTAAGAAGT CCAGCCCACG TCCAGGAGAA GAGGAAGCAG ATTCCTCCTT 3421 TTGAAATGAA GAATATCAAG TAATTCGGGG GGCATATGAA AGCCACCACA CACCACAGGG 3481 ATCTTTTTAG AGCATACTTC TTATACCATC ACTGTAGTTC CTTAAGACTC AGGGGCAAAG 3541 CCTCACTTCC TTAGCACCCA GTGAAGACCA CGCTTACTCC CTCACTCAAC CTCTTGCTAC 3601 TTCCCACCTC TCCTGTCCAA CATCTAGTGT CACTTTCCAG AACATACCAA CAGCTTCCCC 3661 AGTTCTGTGC CTCTGCTCAG GCTGTTCCCC CTGCCTGGTC CACTTGTCCT CCTTCTTGTC 3721 CGGTCAAAAT GCTTCTTATC CTTCAAGACC CAGCTCTAGA GTCACCTCCA ACCCCTTACC 3781 CACCAGCCCC CTCTCCAAGT CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC 3841 CACCCTCTGG GCCACAGTTG TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG GTGTCTTCTT

3901 TGTGTTCTTG CACTCAGGGC AGAGCTCAGC ACAGAGCAGA CGCTCAAAAA ACATTTAAAG 3961 GATAGAAGCA TTGATTTGTG GGTCCCCCAG TCTGGCTCCA GGATGCCAGC CAGCTGCTCC

4021 TAGAAGCAAA CGGACTTTTC CTGGGAAATC CCAGAGGTGA TGATCAGTAA TCTCTCCCGT 4081 GACTCGTAGT TCAGCTCTTC CTCCATGAGC CTGACTATCA GTGGACCTTC CAGAAAGAGC 4141 CCCTTTTCCT TCTCTCACCC ACAGCACAGG GCACTGGGAA AATGCCCAAT GAGTCCTGCC 4201 TCTGGGTTGT GCTTTGGACT TTTCAGTGTG TCTCGCATCC ACTCTTCAAC TTGAATGTTG 4261 CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATTCAGGATG AGAGCAATAC CCTACTCCAA 4321 AGAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAATTTGC CCAAGACCAC ACAGCTAGGA 4381 GTGGAACTCA TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GGTAGAGATG AATTACAGCA 4441 ACAAGTCTAG AAAGGTGCCT GCCCTATGGT CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA 4501 GCCAGTGGGT TAAAGATGAG GTCACCAACA ACGGTGGTGT TGGAGTTTAC CACTGATAAT 4561 AAGGGTGCAA AATGTAAATT ACTAATGTTT ATTGAGCCTA GTGCAGTGCG TGGGGCATTT 4621 TGCACATTGT CTCTGATCCC TATGACAACC CTGAGAGGTA GTGGTTTTAA CTGCCATGTT 4681 ACAGGTGAGG TCATTGTGGT TCAAGGACGT TAAGTAACTT CCCCAGCGTG ACACGGCTTA 4741 TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT GGCTGCAAAG TCCCCACCCC 4801 CCTCGCCATC TGTATCCTCC AATCACTTCA GTGCTTTGCT GCATAGAAGG TAACGGAAAT 4861 CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCTC 4921 CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATT TTTCTCTTTT AATAAATTAA 4981 CTCACCCACC ACACGGCTTT GAGAGGCTCA AAGTTGACCA ACTCCCTTGG GAGGGCCCCG 5041 GTTGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC TTCAAGGAGG TCAAGGGTCC 5101 AACACTTGAG ATTGTTAGTG CTGTTGGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC 5161 CTCGAGATGA AGAACATGAG GCCCCCGTTT AGAACCAAGG ATCAGAGGGG GCTCTGTAAG 5221 ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT 5281 CGGCTTCTCC TTGTCCTGGC TGGTTGTCCT TAACCCCTGT CTCCTTCTGG ACCAGTTTTT 5341 GTCCTTCCCT TGTGACCGCT GAGGGGTAAC AGCCTCTTTC CACTTTCTTT CAGCGCCGAC 5401 ATGCTCAATG TCACCTTGCA AGGGCCCACT CTTAACGGGA CCTTTGCCCA GAGCAAATGC 5461 CCCCAAGTGG AGTGGCTGGG CTGGCTCAAC ACCATCCAGC CCCCCTTCCT CTGGGTGCTG 5521 TTCGTGCTGG CCACCCTAGA GAACATCTTT GTCCTCAGCG TCTTCTGCCT GCACAAGAGC 5581 AGCTGCACGG TGGCAGAGAT CTACCTGGGG AACCTGGCCG CAGCAGACCT GATCCTGGCC 5641 TGCGGGCTGC CCTTCTGGGC CATCACCATC TCCAACAACT TCGACTGGCT CTTTGGGGAG 5701 ACGCTCTGCC GCGTGGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG CATCTGTTTC 5761 CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG 5821 ATGCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTGGGGGTG TACGCTGCTC 5881 CTGAGCTCAC CCATGCTGGT GTTCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC 5941 GTCACCGCTT GTGTCATCAG CTACCCATCC CTCATCTGGG AAGTGTTCAC CAACATGCTC 6001 CTGAATGTCG TGGGCTTCCT GCTGCCCCTG AGTGTCATCA CCTTCTGCAC GATGCAGATC 6061 ATGCAGGTGC TGCGGAACAA CGAGATGCAG AAGTTCAAGG AGATCCAGAC GGAGAGGAGG 6121 GCCACGGTGC TAGTCCTGGT TGTGCTGCTG CTATTCATCA TCTGCTGGCT GCCCTTCCAG 6181 ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGGCATCC TCTCCAGCTG CCAGGACGAG 6241 CGCATCATCG ATGTAATCAC ACAGATCGCC TCCTTCATGG CCTACAGCAA CAGCTGCCTC 6301 AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTTCCGAA AGAAGTCTTG GGAGGTGTAC 6361 CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA TTCAGATGGA GAACTCCATG 6421 GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTGCA GGACTGGGCA 6481 GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA ATTTGTGTAA GGATTGAGGG 6541 ACAGTTGCTT TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG EPI-109 591

6601 AAATGAGTTG ATGTCTCCGG TAAAACACCG GAGACTAATT CCTGCCCTGC CCAATTTTGC 6661 AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA 6721 ACAGCATTAC TGTTCTTATT TGCTGCCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGTG 6781 GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA CTGAGCTTCC CTCCCGTGTG TTCTCCGTCC 6841 CTGCCCCAGC AAGACAACTT AGATCTCCAG GAGAACTGCC ATCCAGCTTT GGTGCAATGG 6901 CTGAGTGCAC AAGTGAGTTG TTGCCCTGGG TTTCTTTAAT CTATTCAGCT AGAACTTTGA 6961 AGGACAATTT CTTGCATTAA TAAAGGTTAA GCCCTGAGGG GTCCCTGATA ACAACCTGGA 7021 GACCAGGATT TTATGGCTCC CCTCACTGAT GGACAAGGAG GTCTGTGCCA AAGAAGAATC 7081 CAATAAGCAC ATATTGAGCA CTTGCTGTAT ATGCAGTATT GAGCACTGTA GGCAAGAGGG 7141 AAGAAAGAGA AGGAGCCATC TCCATCTTGA AGGAACTCAA AGACTCAAGT GGGAACGACT 7201 GGGCACTGCC ACCACCAGAA AGCTGTTCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA 7261 TATGGACAGC AGAAGGGGGA GCCAGGTTCC AGCTCACCAA TACTATTGCA CACCACCTGT 7321 CCTGCCTC

(2) INFORMATION FOR SEQ ID NO: 2446: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2221 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2446:

1 CTGCAGAAAA CAGCCTGAGC TCCACCTCGG CTTCTCCTTG CCCTGGCTGG TTGTCCTTAA

61 CCCCTGTCTC CTTCTGGACC AGTTTTTGTC CTTCCCTTGT GACCCTGAGG GGTAACAGCC

121 TCTTTTCCAC TTTCTTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTT

181 AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC

241 ATCCAGCCCC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTTTGTC

301 CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC

361 CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC

421 AACAACTTCG ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC

481 ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC

5 1 CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC

601 TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG

661 AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC

721 ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT

781 GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG

841 TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA

901 TTCATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC

961 GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC

1021 TTCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC

1081 TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA

1141 GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC

1201 CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT

1261 GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC

1321 AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG

1381 ACTAATTCCT GNCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA

1441 CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT

1501 GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGCAGGGAGA GGAGTGACTG

1561 AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG

1621 AACTGCCATC CAGCTTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT

1681 CTTTAATCTA TTCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC

1741 CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA

1801 CAAGGGAGGT CTGTGCCAAA GAAGAATCCA ATAAGCACAT ATTGAGCACT TGCTGTATAT

1861 GCAGTATTGA GCACTGTAGG CAAGAGGGAA GAAAGAGAAG GAGCCATCTC CATCTTGAAG

1921 GAACTCAAAG ACTCAAGTGG GAACGACTGG CACTGCCACC ACCAGAAAGC TGTTCGACGA

1981 GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA

2041 GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTC TTCTGTAACA

2101 TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG

2161 TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA

2221 AAAGACACTG AGGTCTAGA

(2) INFORMATION FOR SEQ ID NO: 2447: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2461 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2447:

1 TGATCCTATC ACAACCTGAG AGTAGTTTTT ACTCCATTTA CAGGTGAGGT CATTGTGGTT 61 CAAGGACGTT AAGTAACTTC CCCAGCTCAC ACGGCTTATA AGTAAGGCAG CCAGGATGTG EPI-109 592

121 AACCCAGTAG GACTATCTGG CTGCAAAGTC CCCACCCTCC CTCGCCATCT GTATCCTCCA

181 ATCATCTTCA GTGCTTTGCT GATAGAAGGT ACGGAAATAC GATGCCACAG ACTGTCCAGG

241 AAGACAGAAA CTAGGCAGAT GGGCTGGCCA TGGTCTCCAA GCCAGACTGG AATCTCCAGG

301 TCTGGAATGA TATCATTTTT CTCTTTTAAT AAATTAACTC ACCCACCACA CGGCTTTGAG

361 AGGCTCAAAG GTGACCAACT CCCTTGGGAG GGCCCCGGTT GATAAGGAAG GAATGTGAAT

421 CCTCCCATCA CGGAAGCTTC AAGGAGGTCA AGGGTCCAAC ACTTGAGATT GTTAGTGCTG

481 TTGGTGGATA CTGCAGAATA TCCAGTGGAG CCTCAGATGA AGAACATGAG GCCCCGTTTA

541 GATCCAAGGA TCAGAGGGGG CTCTGTAAGA CCCAGGGGAG TCAGGTGCAC TGGAGCGCGG

601 GCTGCAGAAA ACAGCCTGAG CTCCACCTCG GCTTCTCCTT GCCCTGGCTG GTTGTCCTTA

661 ACCCCTGTCT CCTTCTGGAC CAGTTTTTGT CCTTCCCTTG TGACCTGAGG GGTAACAGCC

721 TCTTTTCCAC TTTCTTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTT

781 AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC

841 ATCCAGCCCC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTTTGTC

901 CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC

961 CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC

1021 AACAACTTCG ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC

1081 ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC

1141 CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC

1201 TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG

1261 AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC

1321 ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT

1381 GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG

1441 TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA

1501 TTCATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC

1561 GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC

1621 TTCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC

1681 TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA

1741 GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC

1801 CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT

1861 GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC

1921 AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTGTTGA TGTCTCCGGT AAAACACCGG

1981 AGACTAATTC CTGCCCTGCC CAATTTTCGA GGGAGCATGG CTGTGAGGAT GGGGTGAACT

2041 CACGCACAGC CAAGGACTCC AAAATCACAA CAGCATTACT GTTCTTATTT GCTGCCACAC

2101 CTGAGCCAGC CTGCTCCTTC CCAGGAGTGG AGGAGGCCTG GGGGAGGGAG AGGAGTGACT

2161 GAGCTTCCCT CCCGTGTGTT CTCCGTCCCT GCCCCAGCAA GACAACTTAG ATCTCCAGGA

2221 GAACTGCCAT CCACGTTTGG TGCAATGGCT GAGTGCACAA GTGAGTTGTT GCCCTGGGTT

2281 TCTTTAATCT ATCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC

2341 CTGAGGGGTC CCTTGATAAC AACCTGGAGA CCAGGATTTT ATGGCTCCCC TCACTGATGG

2401 ACAAGGAGGT CTGTGCCAAA GAAGAATCAA TAAGCACATA TGAGCACTTC TGTATATCAG

2461 TATTGAGCAC TGTAGGCA

(2) INFORMATION FOR SEQ ID NO:2448: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1201 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2448:

1 ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTT GTGAGGACTC CGTGCCCACC

61 ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG

121 ACCTTTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG

181 CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC

241 GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC

301 GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC

361 TTCGACTGGC TCTTTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC

421 CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG

481 AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG

541 ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG

601 TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG

661 GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC

721 ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG

781 GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC

841 ATCTGCTGGC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC

901 CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG

961 GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA

1021 AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC

1081 ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT

1141 CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG

1201 AATTTGTGTA AGGATTGAGG GACAGTTGCT T EPI-109 593

(2) INFORMATION FOR SEQ ID NO:2449: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1201 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2449:

1 ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTC GTGAGGACTC CGTGCCCACC

61 ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG

121 ACCTTTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG

181 CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC

241 GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC

301 GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC

361 TTCGACTGGC TCTTTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC

421 CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG

481 AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG

541 ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG

601 TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG

661 GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC

721 ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG

781 GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC

841 ATCTGCTGGC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC

901 CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG

961 GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA

1021 AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC

1081 ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT

1141 CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG

1201 AATTTGTGTA AGGATTGAGG GACAGTTGCT T

(2) INFORMATION FOR SEQ ID NO: 2450: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 241 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2450:

1 GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA

61 GGGGTGGGGA CGGTGGGGAC ATCAGGCTGC CCCGCAGTAC CAGGGAGCGA CTGAAGTGCC

121 CATGCCGCTT GCTCCGGAGA AGGTGGGTGC CGGGCAGGGG CTGCTCCAGC CGCCTCACCT

181 CTGCTGGGAG GACAAACTGT CCCAGCACAG AGGGAGGGAG GGAGGGCAGG CAGCGGGGAG

241 AAGTTTCCCT GTGGTCGTGG GGAGTT

(2) INFORMATION FOR SEQ ID NO:2451: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 241 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2451:

1 GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA

61 GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC

121 TGAAGTGCCC ATGCCGCTTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC

181 GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC

241 AGCGGGGAGA AGTTTCCCTG TGGTCGTGGG GAGTT

(2) INFORMATION FOR SEQ ID NO: 2452: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1441 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2452:

1 GAGCTCTTCA ATATTTTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA 61 CACACCTTTT CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA 121 CTGGCAAGTC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC 181 AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT 241 TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGTTTCC 301 CTGTCTCCAT GATGATGGGA TCAGGCTTGA TTGCTGGTTT GTAGGCTTGT TATGAATCAA 361 GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTTCC EPI-109 594

421 CCAGATCCAC TGGGCCCACT CTTATCTGTT CTCTTCTGAA GGAAGGGTTT TAAGGCTTCA

481 AAAAAAAATG TTTTGAAAGT CCCTGCCCTT TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT

541 GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAAAC TGAGAAAGCC AGCCTGAGCC

601 TTGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA

661 GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGCC ACTGTCGCCC TTGGGAGCCG

721 TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTTTA

781 CACCTTCCGC GTAAACGCCC ACTGTTTACA TCCAAAACTC AGACACAAAA TAACCACCTC

8 1 AAGAAGATAA ATAATGATAA GAAATAAATG TTACGCGAGG CAAATTTATT CACATGGGGC

901 TTCCCAGGCC ACTTTGTGGT CAGCCGGGAG GGACGTTTTT GCCGTCCCAC GACTCCAACG

961 GGCAGCCGGG CCTACGCAAA CATGGAAATC TTCCAAGAGC CTCCCTGGCC CCCAGGGCTC

1021 AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCTT CCCGGCCCCA CAGCCAGCCT

1081 GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG

1141 CTGATGACAT CACTACCCAG CCCTTCAAAG ATGAGCTGTT CCCGCCGCCA CTCCAGCTCT

1201 GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC

1261 CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGAGAAG GTGGGTGCCG

1321 GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG

1381 GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AGTTGGGAAA

1441 AGTTCCCTTC CTTCCGGAGG GAGG

(2) INFORMATION FOR SEQ ID NO: 2453: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2581 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2453:

1 CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT

61 GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC

121 AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG

181 ACTAATTCCT GCCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA

241 CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT

301 GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG

361 AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG

421 AACTGCCATC CAGCTTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT

481 CTTTAATCTA TTCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC

541 CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA

601 CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA TTGAGCACTT GCTGTATATG

661 CAGTATTGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCTTGAAGG

721 AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAAGC TGTTCGACGA

781 GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA

841 GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTT TTATGTAACA

901 TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG

961 TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA

1021 AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC

1081 GGTGTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTT CCACCTGTCA

1141 TTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCATTTGGAG AGAAGGCCAT

1201 GTCTTCAAAG TCTGATTTGT GATGAGGCAG AGGAAGATAT TTCTAATCGG TCTTGCCCAG

1261 AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG

1321 GCCTGCTCAG GGACTGTTCC TGTCTCAGCA ACCAAGGGAT TGTTCCTGTC AATCAATGGT

1381 TTATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGTGT

1441 TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT AAATGAATAT TTATTAGCTG

1501 GTTGGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA

1561 CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT

1621 AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA

1681 ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA

17 1 ACCTAGAAGG GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG 1801 AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGTTA

1861 GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC 1921 TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC 1981 TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATTTACAT 2041 GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAAT TTTAAAGCAA AAGCGTGAAA 2101 AAAAAGATTC CCTCCTTACC CCCAACCCAC TCTTTTTTCC CACCACCCAC TCTCCTCTGC 2161 CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATTTAGTATT 2221 AGTATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC 2281 TGTGTTTTGT CACACAGGGC AGTCATTCAG CACCAGAGCA CGTGATGGTC TGAGACTCTC 2341 TTAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA 2401 CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC 2461 TGTCCTGTGA AAGACTCAAT GAGCTGTTAT GTTGTAAACA GGAAGCATTT CACATCCAAA 2521 CGAGAAAATC ATGTAAACAT GTGTCTTTTC TGTAGAGCAT AATAAATGGA TGAGGTTTTT EPI-109 595

2581 GCAAAAAAAA AAAAAAAAA

(2) INFORMATION FOR SEQ ID NO: 2454: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 7321 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2454:

1 AAATGATAGA CCGTCAATAA TTTGTTAAAT GCTTTTTAAA ATGAATGCTT TAAGCCGGGT

61 GCAGTGCCTC ACATCTGTAA TCCCAGCACT TTGGAGCCGA GCGGGTGGAT TGTGTGAGGT

121 CAGGAGTTCG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCTCTACC AAAAATACAA

181 AAATTAGCCA GGCATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG

241 GAGAATCGCT TGAACCCGGG AGGCAAGGTT GCAGTGAGCC AAGATTACGC CATTGTACTC

301 CAGCCTGGGT GACAGAGAGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATTAC

361 GCTTCAAACA CATGATCTCT CACCACTGTT GAATTTTCTT TCTATGAGCC CAGGAGGGCC

421 TCTCAGAGAG GAAAGCTCCT AGGTCTTCCT TTCCCTCTGC AAACTCCCTG CCTTGAAGGT

481 TCAGAAGGAC TGTGCGTGCT CGTTGCATCC TTTGCAAGTG TCCAAACCCT GATCCCAGCT

5 1 GTGCTTAGGG GTTCCTGCAA ACCTTTTCCA GGTGTTAATT ACCTCCCACT TCATTTCCTG

601 TTTACCAACT CAGCTTTTTG TTTTAGTGTG TTTGAATTCC CTGAACTGAC CGTTGTCTGA

661 TCTCCACCTC CCAACTGAAT TAGGGGAGCT GGGCTTCTGG AAACCCAGGT GCCGGGTGTT

721 GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACACACAC

781 ACCCACATAC CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TTGGACATGC

841 ATAGACCACA GCTTTCCACA CCCTTCCTAG ACAGGGGTCA CTTGGTATCC TGGAGAGAGT

901 GTGAAGTCCT GGAATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA

961 CAAGTCACCA CCAACCCATC TGCGCCTTGT TTACCTCCTC TGTGAGGCAA GCACAGAGCC

1021 CATGCCTGCC CCCCTGGATG GGAGTGATGT GAAACTTGAA GGGCGGTCAG AGCAAGGGTC

1081 GGGAATGGAA GGCCCTTGGG AAAAAAGGCC CTTTCAACTA GGGGCACAGA GGAGGCCCTG

1141 GGCTGAGAAC TTGACAGCAC CTTGTAATTG GTAAGCCAAG CCCGAAGGGA CTGGAAATAC

1201 TCAGATGTGT CTGTCTCCCT TATTAGGTTC AAAGTCCCTC AAGACCCTGT CTCCATCACA

1261 GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGACCCAA CCAGCCCTAT

1321 GGGGTCGCAT CCCCACCTGC CTGGAATTCT CCAAAGAACC TCCCCTTTAA CAGTTCCAGC

1381 CTTTAACAGT TCCAGTCTAA ACACATGACC TTTCTCCTCT AAATCAGCCC CCCATCTCTG

1441 CCTTTGCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC CCATCCATGT

1501 CCAATCAAGC ACTAGGCATG TCAGGTTTAC CCTCTAAACT CCTCTGGAAT CCAGTCTCTC

1561 AGTCTCCATC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCTTGCTTC CACTCTACCC

1621 CCACTGCAGT CCTGACTTCC TGAGCAGCAG CCAGGGCCTA ATCGATATTC ACACCAAGCG

1681 CCAACCTGAC TGAGATATCC TCCTGCACCA TCATCCCTCC ACCCTGTTTA GTTCTGCTCA

1741 CCCTCAGTGT TCTCATCAAT AATCCACTCC CCTCACAGGC GCGTTTGGGA CCCCATGTTC 1801 TATGCTCTCA CAGGACCTTT TGCTTGATTT TTCACTGTAC TTAGGTCAGT TTGCAGTTAT

1861 TAAGTGACTG AGCAATGTCT GGCTTCTCCA GTAGACTGTC AGCTCCTAGC CATTGTATAC 1921 CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG AGTCAGGGAC TCAGCAGTCT 1981 CCATTTCTCC GCCCTGCTGG AGAATGCGTG TATTTGGCAA TCCCCAGCCC CTGTGCCATC 2041 TAACCATCTT TTCTTCTCTG TTCAGCCCAG GTGTGGCCTC ACTCACATCC CACTCTGAGT 2101 CCAAATGTTC TCTCCCTGGA AGATATCAAT GTTTCTGTCT GTTCGTGAGG ACTCCGTGCC 2161 CACCACGGCC TCTTTCAGGT GAGTCAAAGG GATTCCTCAG TTCACTAGTT AGGGGAGGTG 2221 GGCAGACACC CTGGAGAACT CCCTGGAAAG CTCAACTCTC ATGCCCCGGA CAACAGTTGA 2281 AGGAACCATG GTGATGTTAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGTTG 2341 GAATCTTGGG AGCAGAGGGA ATGTTCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA 2401 AGGGCACATT CCTGGTTGTT ATATGTTTCT ATCTATCCCA GATGAACTTG GAAGTGAAGG 2461 GAAGAGAGTT AAACATTAAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC 2521 CTTGGAAACA AAATATCTCC AACACATGGC TGACATTTGG TGGGAGATCA GAACACCCTA 2581 AAGAGAGAAT TTAAGGGGAG GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC AGAGGATAGG 2641 GAGATCTGTT CTTGGGGACA GCATTTGCAA GAAACAAGGC TGAGGGGTCC ACTCCAACCT 2701 CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGGCCAT CTCAGCTGGG 2761 GCCACAGTGC ACTGGACCTA TAGTTTCCAA TTCCGCACTC AGCAGGCATC TTTCTGATGA 2821 TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCTTGGCT ACTGTCTTGC 2881 TGAGAAATTT ATAAGCAGCA TCTGGTGCTA TACTTTGGTC TCTAGTGAGT TAGCTCATGA 2941 AAGATGATAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GGTTTTCTGT AGCTACAGAA 3001_, ATGGGGTTGA GGGTTGGACC AAGGGACTAC CCAGGGGAAG TCTTACCTTC AGAGGACTCT 3061 GGAAAGGAGG CTGCAAGTTT TCATGGGTCA AGAATTCAGA GCCCAGTAGA GACAGCTTAT 3121 CTCTGTTCCA AGATGTCTGG GGCCTTGGTT GGAAGATTCA AAGGCTAGGA AACCAGGAGC 3181 CACCAAAAGC GTAACTGGGG CCAGAGGATC CACTTTCAAG GTGGCAAGTT GGTTCCCCCC 3241 ATGTGGCTGC TTGAGTATCC TCACATGGCG GCTCACATCC TTCCAAGTAA GCAATGCAAA 3301 AGGCCAAGAA AGATGCTGCA AAGATGTTAT GACCTAGCCT CAGAAATCAC ACACCATCCC 3361 TGCCACCATT AGTAAGAAGT CCAGCCCACG TCCAGGAGAA GAGGAAGCAG ATTCCTCCTT 3421 TTGAAATGAA GAATATCAAG TAATTCGGGG GGCATATGAA AGCCACCACA CACCACAGGG 3481 ATCTTTTTAG AGCATACTTC TTATACCATC ACTGTAGTTC CTTAAGACTC AGGGGCAAAG 3541 CCTCACTTCC TTAGCACCCA GTGAAGACCA CGCTTACTCC CTCACTCAAC CTCTTGCTAC EPI-109 596

3601 TTCCCACCTC TCCTGTCCAA CATCTAGTGT CACTTTCCAG AACATACCAA CAGCTTCCCC 3661 AGTTCTGTGC CTCTGCTCAG GCTGTTCCCC CTGCCTGGTC CACTTGTCCT CCTTCTTGTC 3721 CGGTCAAAAT GCTTCTTATC CTTCAAGACC CAGCTCTAGA GTCACCTCCA ACCCCTTACC 3781 CACCAGCCCC CTCTCCAAGT CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC 3841 CACCCTCTGG GCCACAGTTG TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG GTGTCTTCTT 3901 TGTGTTCTTG CACTCAGGGC AGAGCTCAGC ACAGAGCAGA CGCTCAAAAA ACATTTAAAG 3961 GATAGAAGCA TTGATTTGTG GGTCCCCCAG TCTGGCTCCA GGATGCCAGC CAGCTGCTCC 4021 TAGAAGCAAA CGGACTTTTC CTGGGAAATC CCAGAGGTGA TGATCAGTAA TCTCTCCCGT 4081 GACTCGTAGT TCAGCTCTTC CTCCATGAGC CTGACTATCA GTGGACCTTC CAGAAAGAGC 4141 CCCTTTTCCT TCTCTCACCC ACAGCACAGG GCACTGGGAA AATGCCCAAT GAGTCCTGCC 4201 TCTGGGTTGT GCTTTGGACT TTTCAGTGTG TCTCGCATCC ACTCTTCAAC TTGAATGTTG 4261 CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATTCAGGATG AGAGCAATAC CCTACTCCAA 4321 AGAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAATTTGC CCAAGACCAC ACAGCTAGGA 4381 GTGGAACTCA TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GGTAGAGATG AATTACAGCA 4441 ACAAGTCTAG AAAGGTGCCT GCCCTATGGT CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA 4501 GCCAGTGGGT TAAAGATGAG GTCACCAACA ACGGTGGTGT TGGAGTTTAC CACTGATAAT 4561 AAGGGTGCAA AATGTAAATT ACTAATGTTT ATTGAGCCTA GTGCAGTGCG TGGGGCATTT 4621 TGCACATTGT CTCTGATCCC TATGACAACC CTGAGAGGTA GTGGTTTTAA CTGCCATGTT 4681 ACAGGTGAGG TCATTGTGGT TCAAGGACGT TAAGTAACTT CCCCAGCGTG ACACGGCTTA 4741 TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT GGCTGCAAAG TCCCCACCCC 4801 CCTCGCCATC TGTATCCTCC AATCACTTCA GTGCTTTGCT GCATAGAAGG TAACGGAAAT 4861 CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCTC 4921 CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATT TTTCTCTTTT AATAAATTAA

4981 CTCACCCACC ACACGGCTTT GAGAGGCTCA AAGTTGACCA ACTCCCTTGG GAGGGCCCCG 5041 GTTGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC TTCAAGGAGG TCAAGGGTCC 5101 AACACTTGAG ATTGTTAGTG CTGTTGGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC 5161 CTCGAGATGA AGAACATGAG GCCCCCGTTT AGAACCAAGG ATCAGAGGGG GCTCTGTAAG 5221 ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT 5281 CGGCTTCTCC TTGTCCTGGC TGGTTGTCCT TAACCCCTGT CTCCTTCTGG ACCAGTTTTT 5341 GTCCTTCCCT TGTGACCGCT GAGGGGTAAC AGCCTCTTTC CACTTTCTTT CAGCGCCGAC 5401 ATGCTCAATG TCACCTTGCA AGGGCCCACT CTTAACGGGA CCTTTGCCCA GAGCAAATGC 5461 CCCCAAGTGG AGTGGCTGGG CTGGCTCAAC ACCATCCAGC CCCCCTTCCT CTGGGTGCTG 5521 TTCGTGCTGG CCACCCTAGA GAACATCTTT GTCCTCAGCG TCTTCTGCCT GCACAAGAGC 5581 AGCTGCACGG TGGCAGAGAT CTACCTGGGG AACCTGGCCG CAGCAGACCT GATCCTGGCC 5641 TGCGGGCTGC CCTTCTGGGC CATCACCATC TCCAACAACT TCGACTGGCT CTTTGGGGAG 5701 ACGCTCTGCC GCGTGGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG CATCTGTTTC 5761 CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG 5821 ATGCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTGGGGGTG TACGCTGCTC 5881 CTGAGCTCAC CCATGCTGGT GTTCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC

5941 GTCACCGCTT GTGTCATCAG CTACCCATCC CTCATCTGGG AAGTGTTCAC CAACATGCTC 6001 CTGAATGTCG TGGGCTTCCT GCTGCCCCTG AGTGTCATCA CCTTCTGCAC GATGCAGATC 6061 ATGCAGGTGC TGCGGAACAA CGAGATGCAG AAGTTCAAGG AGATCCAGAC GGAGAGGAGG 6121 GCCACGGTGC TAGTCCTGGT TGTGCTGCTG CTATTCATCA TCTGCTGGCT GCCCTTCCAG 6181 ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGGCATCC TCTCCAGCTG CCAGGACGAG 6241 CGCATCATCG ATGTAATCAC ACAGATCGCC TCCTTCATGG CCTACAGCAA CAGCTGCCTC 6301 AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTTCCGAA AGAAGTCTTG GGAGGTGTAC 6361 CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA TTCAGATGGA GAACTCCATG 6421 GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTGCA GGACTGGGCA 6481 GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA ATTTGTGTAA GGATTGAGGG 6541 ACAGTTGCTT TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG 6601 AAATGAGTTG ATGTCTCCGG TAAAACACCG GAGACTAATT CCTGCCCTGC CCAATTTTGC 6661 AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA 6721 ACAGCATTAC TGTTCTTATT TGCTGCCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGTG 6781 GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA CTGAGCTTCC CTCCCGTGTG TTCTCCGTCC 6841 CTGCCCCAGC AAGACAACTT AGATCTCCAG GAGAACTGCC ATCCAGCTTT GGTGCAATGG 6901 CTGAGTGCAC AAGTGAGTTG TTGCCCTGGG TTTCTTTAAT CTATTCAGCT AGAACTTTGA 6961 AGGACAATTT CTTGCATTAA TAAAGGTTAA GCCCTGAGGG GTCCCTGATA ACAACCTGGA 7021 GACCAGGATT TTATGGCTCC CCTCACTGAT GGACAAGGAG GTCTGTGCCA AAGAAGAATC 7081 CAATAAGCAC ATATTGAGCA CTTGCTGTAT ATGCAGTATT GAGCACTGTA GGCAAGAGGG 7141 AAGAAAGAGA AGGAGCCATC TCCATCTTGA AGGAACTCAA AGACTCAAGT GGGAACGACT 7201 GGGCACTGCC ACCACCAGAA AGCTGTTCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA 7261 TATGGACAGC AGAAGGGGGA GCCAGGTTCC AGCTCACCAA TACTATTGCA CACCACCTGT 7321 CCTGCCTC

(2) INFORMATION FOR SEQ ID NO:2455: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2221 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single EPI-109 597

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2455:

1 CTGCAGAAAA CAGCCTGAGC TCCACCTCGG CTTCTCCTTG CCCTGGCTGG TTGTCCTTAA

61 CCCCTGTCTC CTTCTGGACC AGTTTTTGTC CTTCCCTTGT GACCCTGAGG GGTAACAGCC

121 TCTTTTCCAC TTTCTTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTT

181 AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC

241 ATCCAGCCCC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTTTGTC

301 CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC

361 CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC

421 AACAACTTCG ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC

481 ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC

541 CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC

601 TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG

661 AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC

721 ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT

781 GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG

841 TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA

901 TTCATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC

961 GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC

1021 TTCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC

1081 TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA

1141 GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC

1201 CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT

1261 GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC

1321 AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG

1381 ACTAATTCCT GNCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA

1441 CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT

1501 GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGCAGGGAGA GGAGTGACTG

1561 AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG

1621 AACTGCCATC CAGCTTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT

1681 CTTTAATCTA TTCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC

1741 CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA 1801 CAAGGGAGGT CTGTGCCAAA GAAGAATCCA ATAAGCACAT ATTGAGCACT TGCTGTATAT

1861 GCAGTATTGA GCACTGTAGG CAAGAGGGAA GAAAGAGAAG GAGCCATCTC CATCTTGAAG 1921 GAACTCAAAG ACTCAAGTGG GAACGACTGG CACTGCCACC ACCAGAAAGC TGTTCGACGA 1981 GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA 2041 GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTC TTCTGTAACA 2101 TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG 2161 TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA 2221 AAAGACACTG AGGTCTAGA

(2) INFORMATION FOR SEQ ID NO: 2456: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2461 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2456:

1 TGATCCTATC ACAACCTGAG AGTAGTTTTT ACTCCATTTA CAGGTGAGGT CATTGTGGTT

61 CAAGGACGTT AAGTAACTTC CCCAGCTCAC ACGGCTTATA AGTAAGGCAG CCAGGATGTG

121 AACCCAGTAG GACTATCTGG CTGCAAAGTC CCCACCCTCC CTCGCCATCT GTATCCTCCA

181 ATCATCTTCA GTGCTTTGCT GATAGAAGGT ACGGAAATAC GATGCCACAG ACTGTCCAGG

241 AAGACAGAAA CTAGGCAGAT GGGCTGGCCA TGGTCTCCAA GCCAGACTGG AATCTCCAGG

301 TCTGGAATGA TATCATTTTT CTCTTTTAAT AAATTAACTC ACCCACCACA CGGCTTTGAG

361 AGGCTCAAAG GTGACCAACT CCCTTGGGAG GGCCCCGGTT GATAAGGAAG GAATGTGAAT

421 CCTCCCATCA CGGAAGCTTC AAGGAGGTCA AGGGTCCAAC ACTTGAGATT GTTAGTGCTG

481 TTGGTGGATA CTGCAGAATA TCCAGTGGAG CCTCAGATGA AGAACATGAG GCCCCGTTTA

541 GATCCAAGGA TCAGAGGGGG CTCTGTAAGA CCCAGGGGAG TCAGGTGCAC TGGAGCGCGG

601 GCTGCAGAAA ACAGCCTGAG CTCCACCTCG GCTTCTCCTT GCCCTGGCTG GTTGTCCTTA

661 ACCCCTGTCT CCTTCTGGAC CAGTTTTTGT CCTTCCCTTG TGACCTGAGG GGTAACAGCC

721 TCTTTTCCAC TTTCTTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTT

781 AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC

841 ATCCAGCCCC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTTTGTC

901 CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC

961 CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC

1021 AACAACTTCG ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC

1081 ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC

1141 CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC

1201 TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG EPI-109 598

1261 AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC

1321 ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT

1381 GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG

1441 TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA

1501 TTCATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC

1561 GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC

1621 TTCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC

1681 TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA

1741 GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC

1801 CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT

1861 GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC

1921 AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTGTTGA TGTCTCCGGT AAAACACCGG

1981 AGACTAATTC CTGCCCTGCC CAATTTTCGA GGGAGCATGG CTGTGAGGAT GGGGTGAACT

2041 CACGCACAGC CAAGGACTCC AAAATCACAA CAGCATTACT GTTCTTATTT GCTGCCACAC

2101 CTGAGCCAGC CTGCTCCTTC CCAGGAGTGG AGGAGGCCTG GGGGAGGGAG AGGAGTGACT

2161 GAGCTTCCCT CCCGTGTGTT CTCCGTCCCT GCCCCAGCAA GACAACTTAG ATCTCCAGGA

2221 GAACTGCCAT CCACGTTTGG TGCAATGGCT GAGTGCACAA GTGAGTTGTT GCCCTGGGTT

2281 TCTTTAATCT ATCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC

2341 CTGAGGGGTC CCTTGATAAC AACCTGGAGA CCAGGATTTT ATGGCTCCCC TCACTGATGG

2401 ACAAGGAGGT CTGTGCCAAA GAAGAATCAA TAAGCACATA TGAGCACTTC TGTATATCAG

2461 TATTGAGCAC TGTAGGCA

(2) INFORMATION FOR SEQ ID NO: 2457: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1201 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2457:

1 ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTT GTGAGGACTC CGTGCCCACC

61 ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG

121 ACCTTTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG

181 CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC

241 GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC

301 GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC

361 TTCGACTGGC TCTTTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC

421 CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG

481 AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG

541 ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG

601 TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG

661 GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC

721 ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG

781 GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC

8 1 ATCTGCTGGC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC

901 CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG

961 GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA

1021 AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC

1081 ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT

11 1 CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG

1201 AATTTGTGTA AGGATTGAGG GACAGTTGCT T

(2) INFORMATION FOR SEQ ID NO:2458: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1201 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2458:

1 ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTC GTGAGGACTC CGTGCCCACC

61 ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG

121 ACCTTTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG

181 CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC

241 GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC

301 GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC

361 TTCGACTGGC TCTTTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC

421 CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG

481 AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG

541 ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG

601 TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG EPI-109 599

661 GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC

721 ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG

781 GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC

841 ATCTGCTGGC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC

901 CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG

961 GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA

1021 AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC

1081 ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT

1141 CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG

1201 AATTTGTGTA AGGATTGAGG GACAGTTGCT T

(2) INFORMATION FOR SEQ ID NO:2459: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 241 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2459:

1 GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA

61 GGGGTGGGGA CGGTGGGGAC ATCAGGCTGC CCCGCAGTAC CAGGGAGCGA CTGAAGTGCC

121 CATGCCGCTT GCTCCGGAGA AGGTGGGTGC CGGGCAGGGG CTGCTCCAGC CGCCTCACCT

181 CTGCTGGGAG GACAAACTGT CCCAGCACAG AGGGAGGGAG GGAGGGCAGG CAGCGGGGAG

241 AAGTTTCCCT GTGGTCGTGG GGAGTT

(2) INFORMATION FOR SEQ ID NO: 2460: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 241 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2460:

1 GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA

61 GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC

121 TGAAGTGCCC ATGCCGCTTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC

181 GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC

241 AGCGGGGAGA AGTTTCCCTG TGGTCGTGGG GAGTT

(2) INFORMATION FOR SEQ ID NO:2461: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1441 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2461:

1 GAGCTCTTCA ATATTTTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA 61 CACACCTTTT CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA 121 CTGGCAAGTC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC 181 AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT 241 TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGTTTCC 301 CTGTCTCCAT GATGATGGGA TCAGGCTTGA TTGCTGGTTT GTAGGCTTGT TATGAATCAA

361 GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTTCC 421 CCAGATCCAC TGGGCCCACT CTTATCTGTT CTCTTCTGAA GGAAGGGTTT TAAGGCTTCA

481 AAAAAAAATG TTTTGAAAGT CCCTGCCCTT TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT 541 GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAAAC TGAGAAAGCC AGCCTGAGCC 601 TTGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA 661 GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGCC ACTGTCGCCC TTGGGAGCCG 721 TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTTTA 781 CACCTTCCGC GTAAACGCCC ACTGTTTACA TCCAAAACTC AGACACAAAA TAACCACCTC 841 AAGAAGATAA ATAATGATAA GAAATAAATG TTACGCGAGG CAAATTTATT CACATGGGGC 901 TTCCCAGGCC ACTTTGTGGT CAGCCGGGAG GGACGTTTTT GCCGTCCCAC GACTCCAACG 961 GGCAGCCGGG CCTACGCAAA CATGGAAATC TTCCAAGAGC CTCCCTGGCC CCCAGGGCTC

1021 AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCTT CCCGGCCCCA CAGCCAGCCT

1081 GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG

1141 CTGATGACAT CACTACCCAG CCCTTCAAAG ATGAGCTGTT CCCGCCGCCA CTCCAGCTCT

1201 GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC

1261 CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGAGAAG GTGGGTGCCG

1321 GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG

1381 GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AGTTGGGAAA

1441 AGTTCCCTTC CTTCCGGAGG GAGG EPI-109 600

(2) INFORMATION FOR SEQ ID NO: 2462: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1381 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2462:

1 CTTTGTGAAG AAGGAATTGG CAACACTGAA ACCTCCAGAA CAAAGGCTGT CACTAAGGTC

61 CCGCTGCCTT GATGGATTAT ACACTTGACC TCAGTGTGAC AACAGTGACC GACTACTACT

121 ACCCTGATAT CTTCTCAAGC CCCTGTGATG CGGAACTTAT TCAGACAAAT GGCAAGTTGC

181 TCCTTGCTGT CTTTTATTGC CTCCTGTTTG TATTCAGTCT TCTGGGAAAC AGCCTGGTCA

241 TCCTGGTCCT TGTGGTCTGC AAGAAGCTGA GGAGCATCAC AGATGTATAC CTCTTGAACC

301 TGGCCCTGTC TGACCTGCTT TTTGTCTTCT CCTTCCCCTT TCAGACCTAC TATCTGCTGG

361 ACCAGTGGGT GTTTGGGACT GTAATGTGCA AAGTGGTGTC TGGCTTTTAT TACATTGGCT

421 TCTACAGCAG CATGTTTTTC ATCACCCTCA TGAGTGTGGA CAGGTACCTG GCTGTTGTCC

481 ATGCCGTGTA TGCCCTAAAG GTGAGGACGA TCAGGATGGG CACAACGCTG TGCCTGGCAG

541 TATGGCTAAC CGCCATTATG GCTACCATCC CATTGCTAGT GTTTTACCAA GTGGCCTCTG

601 AAGATGGTGT TCTACAGTGT TATTCATTTT ACAATCAACA GACTTTGAAG TGGAAGATCT

661 TCACCAACTT CAAAATGAAC ATTTTAGGCT TGTTGATCCC ATTCACCATC TTTATGTTCT

721 GCTACATTAA AATCCTGCAC CAGCTGAAGA GGTGTCAAAA CCACAACAAG ACCAAGGCCA

781 TCAGGTTGGT GCTCATTGTG GTCATTGCAT CTTTACTTTT CTGGGTCCCA TTCAACGTGG

841 TTCTTTTCCT CACTTCCTTG CACAGTATGC ACATCTTGGA TGGATGTAGC ATAAGCCAAC

901 AGCTGACTTA TGCCACCCAT GTCACAGAAA TCATTTCCTT TACTCACTGC TGTGTGAACC

961 CTGTTATCTA TGCTTTTGTT GGGGAGAAGT TCAAGAAACA CCTCTCAGAA ATATTTCAGA

1021 AAAGTTGCAG CCAAATCTTC AACTACCTAG GAAGACAAAT GCCTAGGGAG AGCTGTGAAA

1081 AGTCATCATC CTGCCAGCAG CACTCCTCCC GTTCCTCCAG CGTAGACTAC ATTTTGTGAG

11 1 GATCAATGAA GACTAAATAT AAAAAACATT TTCTTGAATG GCATGCTAGT AGCAGTGAGC

1201 AAAGGTGTGG GTGTGAAAGG TTTCCAAAAA AAGTTCAGCA TGAAGGATGC CGTGTGTGTT

1261 GTTGCCAACA CTTGGAACAC AATGACTGGA GACATAGTTG TGCATGCCTG GCACAACATC

1321 AAGCCTGTGA TTGTGTTTAT TGATGATGTT GAACAAGTGG TGGCTTTGAG GGATTCTGTA

1381 TGCCAAGTGG AAAAAAAAGA TGTCTCCGGA ATTCGACAGG TTATCA

(2) INFORMATION FOR SEQ ID NO: 2463: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 5161 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2463:

1 TTTCATCTCT CCGGGCTTAT TTGCTGGTTT CTCCGAATGC GGGCCTTGTC TGGTTCACGC

61 TGGATCCCCA ACGCCTAGAA CAGTGCGTGG CACGCAGTTC GTCCTTCTAT AAATATCGGA

121 CTAAATGCAT CTCTGTGATG GTAATACCCA CACGGTGTTG TGAGAATGAA TGAGTGATTC

181 TGTGCAAGTT CCTAGTGATC TGTTACAAAA AGTACTGGTC GCTAAATTAC TCTTATAATA

241 AAGCATACTT TTAGGATAAT AAAGCACTAT TCGCGAATTG GTTACCGCTA TTATGAAATT

301 ACTGAGCAAT ACATATCTAC ATCTGATCAG TCTCCAGAAT TATGCCAAAT CCTACCTTCT

361 TCTGAAAGTA TCTCCTAATT ATCTGCACCT GACCCTAGTG ATGCTGTGAA TGTGCAAGTA

421 TAGCTACATC CTCCGAAGGA AGGATCTTTA CTCCTTTTAC CTCCTGAATG GGCTGCGTCT

481 GCTGAAAGCG CGGGGGAATG GGCGGTTGGA AGCTTGGCCC TACTTCCAGC ATTGCCGCCT

541 ACTGGTTGGG TTACTCCAGC AAGTCACTCC CCTTCCCTGG GCCTCAGTGT CTCTACTGTA

601 GCATTCCCAG GTCTGGAATT CCATCCACTT TAGCAAGGAT GGACGCGCCA CAGAGAGACG

661 CGTTCCTAGC CCGCGCTTCC CACCTGTCTT CAGGCGCATC CCGCTTCCCT CAAACTTAGG

721 AAATGCCTCT GGGAGGTCCT GTCCGGCTCC GGACTCACTA CCGACCACCC GCAAACAGCA

781 GGGTCCCCTG GGCTTCCCAA GCCGCGCACC TCTCCGCCCC GCCCCTGCGC CCTCCTTCCT

841 CGCGTCTGCC CCTCTCCCCC ACCCCGCCTT CTCCCTCCCC GCCCCAGCGG CGCATGCGCC

901 GCGCTCGGAG CGTGTTTTTA TAAAAGTCCG GCCGCGGCCA GAAACTTCAG TTTGTTGGCT

961 GCGGCAGCAG GTAGCAAAGT GACGCCGAGG GCCTGAGTGC TCCAGTAGCC ACCGCATCTG

1021 GAGAACCAGC GGTTACCATG GAGGGGATCA GTGTAAGTCC AGTTTCAACC TGCTTTGTCA

1081 TAAATGTACA AACGTTTGAA CTTAGAGCGC AGCCCCTCTC CGAGCGGGCA GAAGCGGCCA

1141 GGACATTGGA GGTACCCGTA CTCCAAAAAA GGGTCACCGA AAGGAGTTTT CTTGACCATG

1201 CCTATATAGT GCGGGTGGGT GGGGGGGGAG CAGGATTGGA ATCTTTTTCT CTGTGAGTCG

1261 AGGAGAAACG ACTGGAAAGA GCGTTCCAGT GGCTGCATGT GTCTCCCCCT TGAGTCCCGC

1321 CGCGCGCGGC GGCTTGCACG CTGTTTGCAA ACGTAAGAAC ATTCTGTGCA CAAGTGCAGA

1381 GAAGGCGTGC GCGCTGCCTC GGGACTCAGA CCACCGGTCT CTTCCTTGGG GAAGCGGGGA

1441 TGTCTTGGAG CGAGTTACAT TGTCTGAATT TAGAGGCGGA GGGCGGCGTG CCTGGGCTGA

1501 CTTCCCAGGA GGAGATTGCG CCCGCTTTAA CTTCGGGGTT AAGCGCCTGG TGACTGTTCT

1561 TGACACTGGG TGCGTGTTTG TTAAACTCTG TGCGGCCGAC GGAGCTGTGC CAGTCTCCCA

1621 GCACAGTAGG CAGAGGGCGG GAGAGGCGGG TGGACCCACC GCGCCGATCC TCTGAGGGGA

1681 TCGAGTGGTG GCAGCAGCTA GGAGTTGATC CGCCCGCGCG CTTTGGGTTT GAGGGGGAAA

1741 CCTTCCCGCC GTCCGAAGCG CGCCTCTTCC CCACGGCCGC GAGTGGGTCC TGCAGTTCGA EPI-109 601

1801 GAGTTTGGGG TCGTGCAGAG GTCAGCGGAG TGGTTTGACC TCCCCTTTGA CACCGCGCAG 1861 CTGCCAGCCC TGAGATTTGC GCTCCGGGGA TAGGAGCGGG TACGGGGTGA GGGGCGGGGG 1921 CGGTTAAGAC CGCACCTGGG CTGCCAGGTC GCCGCCGCGA AGACTGGCAG GTGCAAGTGG 1981 GGAAACCGTT TGGCTCTCTC CGAGTCCAGT TGTGATGTTT AACCGTCGGT GGTTTCCAGA 2041 AACCTTTTGA AACCCTCTTG CTAGGGAGTT TTTGGTTTCC TGCAGCGGCG CGCAATTCAA 2101 AGACGCTCGC GGCGGAGCCG CCCAGTCGCT CCCCAGCACC CTGTGGGACA GAGCCTGGCG 2161 TGTCGCCCAG CGGAGCCCCT GCAGCGCTGC TTGCGGGCGG TTGGCGTGGG TGTAGTGGGC 2221 AGCCGCGGCG GCCCGGGGCT GGACGACCCG GCCCCCCGCG TGCCCACCGC CTGGAGGCTT 2281 CCAGCTGCCC ACCTCCGGCC GGGTTAACTG GATCAGTGGC GGGGTAATGG GAAGCCACCC 2341 GGGAGAGTGA GGAAATGAAA CTTGGGGCGA GGACCACGGG TGCAGACCCC GTTACCTTCT 2401 CCACCCAGGA AAATGCCCCG CTCCCTAACG TCCCAAACGC GCCAAGTGAT AAACACGAGG 2461 ATGGCAAGAG ACCCACACAC CGGAGGAGCG CCCGCTTGGG GGAGGAGGTG CCGTTTGTTC 2521 ATTTTCTGAC ACTCCCGCCC AATATACCCC AAGCACCGAA GGGCCTTCGT TTTAAGACCG 2581 CATTCTCTTT ACCCACTACA AGTTGCTTGA AGCCCAGAAT GGTTTGTATT TAGGCAGGCG 2641 TGGGAAAATT AAGTTTTTGC GCTTTAGGAG AATGAGTCTT TGCAACGCCC CCGCCCTCCC 2701 CCCGTGATCC TCCCTTCTCC CCTCTTCCCT CCCTGGGCGA AAAACTTCTT ACAAAAAGTT 2761 AATCACTGCC CCTCCTAGCA GCACCCACCC CACCCCCCAC GCCGCCTGGG AGTGGCCTCT 2821 TTGTGTGTAT TTTTTTTTTC CTCCTAAGGA AGGTTTTTTT TCTTCCCTCT AGTGGGCGGG 2881 GCAGAGGAGT TAGCCAAGAT GTGACTTTGA AACCCTCAGC GTCTCAGTGC CCTTTTGTTC 2941 TAAACAAAGA ATTTTGTAAT TGGTTCTACC AAAGAAGGAT ATAATGAAGT CACTATGGGA 3001 AAAGATGGGG AGGAGAGTTG TAGGATTCTA CATTAATTCT CTTGTGCCCT TAGCCCACTA 3061 CTTCAGAATT TCCTGAAGAA AGCAAGCCTG AATTGGTTTT TTAAATTGCT TTAAAAATTT 3121 TTTTTAACTG GGTTAATGCT TGCTGAATTG GAAGTGAATG TCCATTCCTT TGCCTCTTTT 3181 GCAGATATAC ACTTCAGATA ACTACACCGA GGAAATGGGC TCAGGGGACT ATGACTCCAT 3241 GAAGGAACCC TGTTTCCGTG AAGAAAATGC TAATTTCAAT AAAATCTTCC TGCCCACCAT 3301 CTACTCCATC ATCTTCTTAA CTGGCATTGT GGGCAATGGA TTGGTCATCC TGGTCATGGG 3361 TTACCAGAAG AAACTGAGAA GCATGACGGA CAAGTACAGG CTGCACCTGT CAGTGGCCGA 3421 CCTCCTCTTT GTCATCACGC TTCCCTTCTG GGCAGTTGAT GCCGTGGCAA ACTGGTACTT 3481 TGGGAACTTC CTATGCAAGG CAGTCCATGT CATCTACACA GTCAACCTCT ACAGCAGTGT 3541 CCTCATCCTG GCCTTCATCA GTCTGGACCG CTACCTGGCC ATCGTCCACG CCACCAACAG 3601 TCAGAGGCCA AGGAAGCTGT TGGCTGAAAA GGTGGTCTAT GTTGGCGTCT GGATCCCTGC 3661 CCTCCTGCTG ACTATTCCCG ACTTCATCTT TGCCAACGTC AGTGAGGCAG ATGACAGATA 3721 TATCTGTGAC CGCTTCTACC CCAATGACTT GTGGGTGGTT GTGTTCCAGT TTCAGCACAT 3781 CATGGTTGGC CTTATCCTGC CTGGTATTGT CATCCTGTCC TGCTATTGCA TTATCATCTC 3841 CAAGCTGTCA CACTCCAAGG GCCACCAGAA GCGCAAGGCC CTCAAGACCA CAGTCATCCT 3901 CATCCTGGCT TTCTTCGCCT GTTGGCTGCC TTACTACATT GGGATCAGCA TCGACTCCTT 3961 CATCCTCCTG GAAATCATCA AGCAAGGGTG TGAGTTTGAG AACACTGTGC ACAAGTGGAT 4021 TTCCATCACC GAGGCCCTAG CTTTCTTCCA CTGTTGTCTG AACCCCATCC TCTATGCTTT 4081 CCTTGGAGCC AAATTTAAAA CCTCTGCCCA GCACGCACTC ACCTCTGTGA GCAGAGGGTC 4141 CAGCCTCAAG ATCCTCTCCA AAGGAAAGCG AGGTGGACAT TCATCTGTTT CCACTGAGTC 4201 TGAGTCTTCA AGTTTTCACT CCAGCTAACA CAGATGTAAA AGACTTTTTT TTATACGATA 4261 AATAACTTTT TTTTAAGTTA CACATTTTTC AGATATAAAA GACTGACCAA TATTGTACAG 4321 TTTTTATTGC TTGTTGGATT TTTGTCTTGT GTTTCTTTAG TTTTTGTGAA GTTTAATTGA 4381 CTTATTTATA TAAATTTTTT TTGTTTCATA TTGATGTGTG TCTAGGCAGG ACCTGTGGCC 4441 AAGTTCTTAG TTGCTGTATG TCTCGTGGTA GGACTGTAGA AAAGGGAACT GAACATTCCA 4501 GAGCGTGTAG TGAATCACGT AAAGCTAGAA ATGATCCCCA GCTGTTTATG CATAGATAAT 4561 CTCTCCATTC CCGTGGAACG TTTTTCCTGT TCTTAAGACG TGATTTTGCT GTAGAAGATG 4621 GCACTTATAA CCAAAGCCCA AAGTGGTATA GAAATGCTGG TTTTTCAGTT TTCAGGAGTG 4681 GGTTGATTTC AGCACCTACA GTGTACAGTC TTGTATTAAG TTGTTAATAA AAGTACATGT 4741 TAAACTTACT TAGTGTTATG TTCTGATTTC TGTTGACATT CTTTTGGCTA GTAGAAGACA 4801 AAAGTAATAC ATTTATGGTA TGCAAAGCAC TATCCTAGGT ATTTCATTGT AATATTTTAC 4861 TTACCCCTTA TCACAACTCT GATAGATTCT GCTTCTGTTA CTAATTACAT TTTATAGAAG 4921 AGGAAACGGA GGCACAGAAA GCCTAAGTAA CTTGGTTAAA GGCATGTAGT AAGTATCAAA 4981 TCCTGTATTT TAAACCAGGT AACATGACTT AACGAATCTG AAGCCTTCAC CACTTTAAAT 5041 TCAAATGGAA GTTTAGAAAT GGCCAGCCAG CACCTATTTG TATGAAAGGT CATCTTTCAG 5101 AGGATAAGCA TGTATAAAGA AGAAAAGGTA TGCAGTCGTG TTTGGATTTT ACTCCACCAT 5161 C

(2) INFORMATION FOR SEQ ID NO: 2464: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 841 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2464:

1 AGGATGATGG TGATGGGGAA CTAAATGGGG AAATATGGAA GGTCACAGGA AAAGTTAACA

61 CAAGTTAGCA AAAAGTTAAC ATAACACAAA AAGGTCTTGC AGGAAAAAAA AAAGAAAAGA

121 AAAGAAAGAA AAAGTCTCCA AGAATGGTTT GGACAGCCAA AATGAATACT TATAGTCACG

181 TATACCTGCT CACTCCTGAC GCTTCACTCA CACACAGCAC AGGATCTGGT GAGGCTATCA EPI-109 602

241 CTAAATGTGC CACATTGTGG TTAAGTTTTA CCTGATTAAC GAAATGCTCA CACTTCTAAA

301 CTGAGGTCCT TACAGTAGAT TCCTTTTGCA AGATTGTTAC TGGCTTACAA CTTAAAAATA

361 AAGGAAAATC ACAAGGAAAG AAAAGTGGGG AAAAAATCGG AGGAAACTTG CCCCTGCCCT 421 GGCCACCGGC AAGGCTGCCA CAAAGGGGTT AAAAGTTAAG TGGAAGTGGA GCTTGAAGAA 481 GTGGGATGGG GCCTCTCCAG GAAAGCTGAA CGAGGCATCT GGAGCCCGAA CAAACCTCCA 5 1 CCTTTTTTGG CCTCGACGGC GGCAACCCAG CCTCCCTCCT AACGCCCTCC GCCTTTGGGA 601 CCAACCAGGG GAGCTCAAGT TAGTAGCAGC CAAGGAGAGG CGCTGCCTTG CCAAGACTAA 661 AAAGGGAGGG GAGAAGAGAG GAAAAAAGCA AGAATCCCCC ACCCCTCTCC CGGGCGGAGG 721 GGGCGGGAAG AGCGCGTCCT GGCCAAGCCG AGTAGTGTCT TCCACTCGGT GCGTCTCTCT 781 AGGAGCCGCG CGGGAAGGAT GCTGGTCCGC AGGGGCGCGC GCGCAGGGCC CAGGATGCCG 841 CGGGGCTGGA CCGCGCTTTG CTTGCTGAGT TTGCTGC

(2) INFORMATION FOR SEQ ID NO:2465: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2581 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2465:

1 CCTTTTTTGG CCTCGACGGC GGCAACCCAG CCTCCCTCCT AACGCCCTCC GCCTTTGGGA 61 CCAACCAGGG GAGCTCAAGT TAGTAGCAGC CAAGGAGAGG CGCTGCCTTG CCAAGACTAA 121 AAAGGGAGGG GAGAAGAGAG GAAAAAAGCA AGAATCCCCC ACCCCTCTCC CGGGCGGAGG 181 GGGCGGGAAG AGCGCGTCCT GGCCAAGCCG AGTAGTGTCT TCCACTCGGT GCGTCTCTCT 241 AGGAGCCGCG CGGGAAGGAT GCTGGTCCGC AGGGGCGCGC GCGAGGGCCC AGGATGCCGC 301 GGGGCTGGAC CGCGCTTTGC TTGCTGAGTT TGCTGCCTTC TGGGTTCATG AGTCTTGACA 361 ACAACGGTAC TGCTACCCCA GAGTTACCTA CCCAGGGAAC ATTTTCAAAT GTTTCTACAA

421 ATGTATCCTA CCAAGAAACT ACAACACCTA GTACCCTTGG AAGTACCAGC CTGCACCCTG 481 TGTCTCAACA TGGCAATGAG GCCACAACAA ACATCACAGA AACGACAGTC AAATTCACAT 541 CTACCTCTGT GATAACCTCA GTTTATGGAA ACACAAACTC TTCTGTCCAG TCACAGACCT 601 CTGTAATCAG CACAGTGTTC ACCACCCCAG CCAACGTTTC AACTCCAGAG ACAACCTTGA 661 AGCCTAGCCT GTCACCTGGA AATGTTTCAG ACCTTTCAAC CACTAGCACT AGCCTTGCAA 721 CATCTCCCAC TAAACCCTAT ACATCATCTT CTCCTATCCT AAGTGACATC AAGGCAGAAA 781 TCAAATGTTC AGGCATCAGA GAAGTGAAAT TGACTCAGGG CATCTGCCTG GAGCAAAATA 841 AGACCTCCAG CTGTGCGGAG TTTAAGAAGG ACAGGGGAGA GGGCCTGGCC CGAGTGCTGT 901 GTGGGGAGGA GCAGGCTGAT GCTGATGCTG GGGCCCAGGT ATGCTCCCTG CTCCTTGCCC 961 AGTCTGAGGT GAGGCCTCAG TGTCTACTGC TGGTCTTGGC CAACAGAACA GAAATTTCCA

1021 GCAAACTCCA ACTTATGAAA AAGCACCAAT CTGACCTGAA AAAGCTGGGG ATCCTAGATT 1081 TCACTGAGCA AGATGTTGCA AGCCACCAGA GCTATTCCCA AAAGACCCTG ATTGCACTGG 1141 TCACCTCGGG AGCCCTGCTG GCTGTCTTGG GCATCACTGG CTATTTCCTG ATGAATCGCC 1201 GCAGCTGGAG CCCCACAGGA GAAAGGCTGG GCGAAGACCC TTATTACACG GAAAACGGTG 1261 GAGGCCAGGG CTATAGCTCA GGACCTGGGA CCTCCCCTGA GGCTCAGGGA AAGGCCAGTG 1321 TGAACCGAGG GGCTCAGAAA AACGGGACCG GCCAGGCCAC CTCCAGAAAC GGCCATTCAG 1381 CAAGACAACA CGTGGTGGCT GATACCGAAT TGTGACTCGG CTAGGTGGGG CAAGGCTGGG 1441 CAGTGTCCGA GAGAGCACCC CTCTCTGCAT CTGACCACGT GCTACCCCCA TGCTGGAGGT 1501 GACATCTCTT ACGCCCAACC CTTCCCCACT GCACACACCT CAGAGGCTGT TCTTGGGGCC 1561 CTACACCTTG AGGAGGGGGC AGGTAAACTC CTGTCCTTTA CACATTCGGC TCCCTGGAGC 1621 CAGACTCTGG TCTTCTTTGG GTAAACGTGT GACGGGGGAA AGCCAAGGTC TGGAGAAGCT 1681 CCCAGGAACA ATCGATGGCC TTGCAGCACT CACACAGGAC CCCCTTCCCC TACCCCCTCC 1741 TCTCTGCCGC AATACAGGAA CCCCCAGGGG AAAGATGAGC TTTTCTAGGC TACAATTTTC 1801 TCCCAGGAAG CTTTGATTTT TACCGTTTCT TCCCTGTATT TTCTTTCTCT ACTTTGAGGA 1861 AACCAAAGTA ACCTTTTGCA CCTGCTCTCT TGTAATGATA TAGCCAGAAA AACGTGTTGC 1921 CTTGAACCAC TTCCCTCATC TCTCCTCCAA GACACTGTGG ACTTGGTCAC CAGCTCCTCC 1981 CTTGTTCTCT AAGTTCCACT GAGCTCCATG TGCCCCCTCT ACCATTTGCA GAGTCCTGCA 2041 CAGTTTTCTG GCTGGAGCCT AGAACAGGCC TCCCAAGTTT TAGGACAAAC AGCTCAGTTC 2101 TAGTCTCTCT GGGGCCACAC AGAAACTCTT TTTGGGCTCC TTTTTCTCCC TCTGGATCAA 2161 AGTAGGCAGG ACCATGGGAC CAGGTCTTGG AGCTGAGCCT CTCACCTGTA CTCTTCCGAA 2221 AAATCCTCTT CCTCTGAGGC TGGATCCTAG CCTTATCCTC TGATCTCCAT GGCTTCCTCC 2281 TCCCTCCTGC CGACTCCTGG GTTGAGCTGT TGCCTCAGTC CCCCAACAGA TGCTTTTCTG 2341 TCTCTGCCTC CCTCACCCTG AGCCCCTTCC TTGCTCTGCA CCCCCATATG GTCATAGCCC 2401 AGATCAGCTC CTAACCCTTA TCACCAGCTG CCTCTTCTGT GGGTGACCCA GGTCCTTGTT 2461 TGCTGTTGAT TTCTTTCCAG AGGGGTTGAG CAGGGATCCT GGTTTCAATG ACGGTTGGAA 2521 ATAGAAATTT CCAGAGAAGA GAGTATTGGG TAGATATTTT TTCTGAATAC AAAGTGATGT 2581 GTTTAAATAC TGCAATTAAA GTGATACTGA AACAC

(2) INFORMATION FOR SEQ ID NO:2466: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3422 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear EPI-109 603

1) SEQUENCE DESCRIPTION: SEQ ID NO:2466:

AGGATGATGG TGATGGGGAA CTAAATGGGG AAATATGGAA GGTCACAGGA AAAGTTAACA CAAGTTAGCA AAAGTTAAC ATAACACAAA AAGGTCTTGC AGGAAAAAAA AAAGAAAAGA AAAGAAAGAA AAAGTCTCCA AGAATGGTTT GGACAGCCAA AATGAATACT TATAGTCACG TATACCTGCT CACTCCTGAC GCTTCACTCA CACACAGCAC AGGATCTGGT GAGGCTATCA TAAATGTGC CACATTGTGG TTAAGTTTTA CCTGATTAAC GAAATGCTCA CACTTCTAAA CTGAGGTCCT TACAGTAGAT TCCTTTTGCA AGATTGTTAC TGGCTTACAA CTTAAAAATA AAGGAAAATC ACAAGGAAAG AAAAGTGGGG AAAAAATCGG AGGAAACTTG CCCCTGCCCT GGCCACCGGC AAGGCTGCCA CAAAGGGGTT AAAAGTTAAG TGGAAGTGGA GCTTGAAGAA GTGGGATGGG GCCTCTCCAG GAAAGCTGAA CGAGGCATCT GGAGCCCGAA CAAACCTCCA CCTTTTTTGG CCTCGACGGC GGCAACCCAG CCTCCCTCCT AACGCCCTCC GCCTTTGGGA CCAACCAGGG GAGCTCAAGT TAGTAGCAGC CAAGGAGAGG CGCTGCCTTG CCAAGACTAA AAAGGGAGGG GAGAAGAGAG GAAAAAAGCA AGAATCCCCC ACCCCTCTCC CGGGCGGAGG GGGCGGGAAG AGCGCGTCCT GGCCAAGCCG AGTAGTGTCT TCCACTCGGT GCGTCTCTCT AGGAGCCGCG CGGGAAGGAT GCTGGTCCGC AGGGGCGCGC GCGCAGGGCC CAGGATGCCG CGGGGCTGGA CCGCGCTTTG CTTGCTGAGT TTGCTGC CCTTTTTTGG CCTCGACGGC GGCAACCCAG CCTCCCTCCT AACGCCCTCC GCCTTTGGGA CCAACCAGGG GAGCTCAAGT TAGTAGCAGC CAAGGAGAGG CGCTGCCTTG CCAAGACTAA AAAGGGAGGG GAGAAGAGAG GAAAAAAGCA AGAATCCCCC ACCCCTCTCC CGGGCGGAGG GGGCGGGAAG AGCGCGTCCT GGCCAAGCCG AGTAGTGTCT TCCACTCGGT GCGTCTCTCT AGGAGCCGCG CGGGAAGGAT GCTGGTCCGC AGGGGCGCGC GCGAGGGCCC AGGATGCCGC GGGGCTGGAC CGCGCTTTGC TTGCTGAGTT TGCTGCCTTC TGGGTTCATG AGTCTTGACA ACAACGGTAC TGCTACCCCA GAGTTACCTA CCCAGGGAAC ATTTTCAAAT GTTTCTACAA ATGTATCCTA CCAAGAAACT ACAACACCTA GTACCCTTGG AAGTACCAGC CTGCACCCTG TGTCTCAACA TGGCAATGAG GCCACAACAA ACATCACAGA AACGACAGTC AAATTCACAT CTACCTCTGT GATAACCTCA GTTTATGGAA ACACAAACTC TTCTGTCCAG TCACAGACCT CTGTAATCAG CACAGTGTTC ACCACCCCAG CCAACGTTTC AACTCCAGAG ACAACCTTGA AGCCTAGCCT GTCACCTGGA AATGTTTCAG ACCTTTCAAC CACTAGCACT AGCCTTGCAA CATCTCCCAC TAAACCCTAT ACATCATCTT CTCCTATCCT AAGTGACATC AAGGCAGAAA TCAAATGTTC AGGCATCAGA GAAGTGAAAT TGACTCAGGG CATCTGCCTG GAGCAAAATA AGACCTCCAG CTGTGCGGAG TTTAAGAAGG ACAGGGGAGA GGGCCTGGCC CGAGTGCTGT GTGGGGAGGA GCAGGCTGAT GCTGATGCTG GGGCCCAGGT ATGCTCCCTG CTCCTTGCCC AGTCTGAGGT GAGGCCTCAG TGTCTACTGC TGGTCTTGGC CAACAGAACA GAAATTTCCA GCAAACTCCA ACTTATGAAA AAGCACCAAT CTGACCTGAA AAAGCTGGGG ATCCTAGATT TCACTGAGCA AGATGTTGCA AGCCACCAGA GCTATTCCCA AAAGACCCTG ATTGCACTGG TCACCTCGGG AGCCCTGCTG GCTGTCTTGG GCATCACTGG CTATTTCCTG ATGAATCGCC GCAGCTGGAG CCCCACAGGA GAAAGGCTGG GCGAAGACCC TTATTACACG GAAAACGGTG GAGGCCAGGG CTATAGCTCA GGACCTGGGA CCTCCCCTGA GGCTCAGGGA AAGGCCAGTG TGAACCGAGG GGCTCAGAAA AACGGGACCG GCCAGGCCAC CTCCAGAAAC GGCCATTCAG CAAGACAACA CGTGGTGGCT GATACCGAAT TGTGACTCGG CTAGGTGGGG CAAGGCTGGG CAGTGTCCGA GAGAGCACCC CTCTCTGCAT CTGACCACGT GCTACCCCCA TGCTGGAGGT GACATCTCTT ACGCCCAACC CTTCCCCACT GCACACACCT CAGAGGCTGT TCTTGGGGCC CTACACCTTG AGGAGGGGGC AGGTAAACTC CTGTCCTTTA CACATTCGGC TCCCTGGAGC CAGACTCTGG TCTTCTTTGG GTAAACGTGT GACGGGGGAA AGCCAAGGTC TGGAGAAGCT CCCAGGAACA ATCGATGGCC TTGCAGCACT CACACAGGAC CCCCTTCCCC TACCCCCTCC TCTCTGCCGC AATACAGGAA CCCCCAGGGG AAAGATGAGC TTTTCTAGGC TACAATTTTC TCCCAGGAAG CTTTGATTTT TACCGTTTCT TCCCTGTATT TTCTTTCTCT ACTTTGAGGA AACCAAAGTA ACCTTTTGCA CCTGCTCTCT TGTAATGATA TAGCCAGAAA AACGTGTTGC CTTGAACCAC TTCCCTCATC TCTCCTCCAA GACACTGTGG ACTTGGTCAC CAGCTCCTCC CTTGTTCTCT AAGTTCCACT GAGCTCCATG TGCCCCCTCT ACCATTTGCA GAGTCCTGCA CAGTTTTCTG GCTGGAGCCT AGAACAGGCC TCCCAAGTTT TAGGACAAAC AGCTCAGTTC TAGTCTCTCT GGGGCCACAC AGAAACTCTT TTTGGGCTCC TTTTTCTCCC TCTGGATCAA AGTAGGCAGG ACCATGGGAC CAGGTCTTGG AGCTGAGCCT CTCACCTGTA CTCTTCCGAA AAATCCTCTT CCTCTGAGGC TGGATCCTAG CCTTATCCTC TGATCTCCAT GGCTTCCTCC TCCCTCCTGC CGACTCCTGG GTTGAGCTGT TGCCTCAGTC CCCCAACAGA TGCTTTTCTG TCTCTGCCTC CCTCACCCTG AGCCCCTTCC TTGCTCTGCA CCCCCATATG GTCATAGCCC AGATCAGCTC CTAACCCTTA TCACCAGCTG CCTCTTCTGT GGGTGACCCA GGTCCTTGTT TGCTGTTGAT TTCTTTCCAG AGGGGTTGAG CAGGGATCCT GGTTTCAATG ACGGTTGGAA ATAGAAATTT CCAGAGAAGA GAGTATTGGG TAGATATTTT TTCTGAATAC AAAGTGATGT GTTTAAATAC TGCAATTAAA GTGATACTGA AACAC 3422

(2) INFORMATION FOR SEQ ID NO:2467: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 8101 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2467:

1 TCCCAGTTAA TACATAATCA ATATGCAATT TATTAATACA TCTCTCCATG TCCACTCCCC 61 CTGTATCTTG CCATTCTTGA CCTGCATTTC CATCCTCCTT ACCTTCCCTA GAGGCCAACT 121 CATTTTCTTT GAAAAACCTG GCATTTCCCA GAAAAAAAAG TGAAGGGCTG GGAGCTGTCC 181 GTTGTCCTGA TTTGCTCCCT CTGCCCTTGC TTCCAAATGT GGTTGGAAAG AAGCACTATT 241 GAAAAATCCC TAAACGCACC CCTGCAGGGT TGGCTCTACC CTGTAGCCAT GGACACATGC 301 TGTTGATACC ACCTGCCTCA TGAGTCTCAC ATAATTTGCC CTTTCACACT ATCTACCCCA 361 TCAGCCTTAC CAAAACCATA CCTGCATCCT GGGCAGCATC TGCCCTTCAA GAGACTAAGG 421 AATCTCCTTG CAACCAAGAA TGACTAGACC AATGAGACAC CCTTTAAGGC CCCAGCACAA 481 TATAGAAATC CCACAATATG GTAATCCCAG TAAGGAGCTA TCAAGCCATT GCAGGACCAT 541 CTAGAATACA ACTAGAGTAT AGTTCCTTTC AATCCAGGAA CTATACTCTA ACAGCTTGGC EPI-109 604

601 TCACAGGAAC CAGAAGTGAA GATGATGAGG ATCAGGGCTG AGCCTGTGAG CACCAGCTCC 661 ACCACTGACA CCAACCACAG ATTAAACAAG CATCTTGTGG ACCCCTGGGA TGGAAAGAAT 721 AGTTGTTGCC TTATCAACCT CCCCCACAGC CCACACAGAA AAGATAAAAT CATCATGGCT 781 ACAGTGTTAC AGAAGATGAT GACCCAAGGA GTAGGCCTGC CTGAGTGAAT GCTGAGAGTG 841 ATAATGGGAG CAGTAGCATC TCAGAGACTA CAGCAGAAAC CATCCACATA AAGAGCTTTG 901 CCCAAACTTA TGATAAAGGG CACCCTCAGA GACTCTCCCT ACTTTAATAT TAGCCCATTG 961 CAGAAATGGT GAGTGGAAAG AGAAATCTTA GGAAGAACCC CTTAAAAAAG CAAAATGCTT 1021 TTTAGGTTTG TGCTGAAGAG CCTGGAAAAG AAATAAGGAC ACACACGCTG AGAAATCTTC 1081 CTCCTGCCCC AACACTGGGA TAATCTCCAA GGATCTCTCC ATATCTCATT CTCCTGGATA 1141 CACTGTCCAC TCAGAAATAT TGTGCAGAGT GCAGTAATTC AAAAGTGAGC TATTGTGTTA 1201 GGAGTGAAGG CAAGAGTATC GTAAAATAAA TCAAATTTGA AATGAATTCT CTTAAATTGC 1261 TTTATAGATG TTTAATGTAA GCCAGCAGCT ATTAAACGAT AAACCTTAAA TTCGAGAAAA 1321 ACTTGGTCAT TCAGAAACTA TAGAAACAGG CAGGACTTAT TGCGAGGGCA AACACAGAGT 1381 GAGCTCCAGC CTGCTTCAGG AAAATCTGCC AGTGCCATGA AGGATGTACT CTGTCTGCTC 1441 CACTGCACTA CTGCTCAGTA TGAGCCCATG CCATCAGCTG TCCCTGACCC ACAGGAGTTC 1501 TTTAGAAGAG ACTGGTCAAC AAAAGTTTCT AGGGTGTTTT ATACCTGCCA ACTCGAGGGT 1561 TAAAACAAGT TGCATAGAAA TGCTCAATCA AGAAAGACAC AGTCATTACT CAGAGAATAA 1621 TAAACAGCCT GGCAGCACAT GAATGAATAG AAAAAAGATG TTACATGCAA AGCATGAAAT 1681 AACCAAATTC CATAACAGAT GTTAATCTGT AATGTGTTTA GGAGAATTTA GAGGAAGTAT 1741 AAGATTTATT CTTTCATCAA AAAAATTATA GCCAATGAGG ATATATCTAT CAATTATCCA 1801 TCAAGTGGTG ATATGGCAGC ACAAGGTAAA ACACAAAGGA ATAAAACCAA CGTTTATTAA 1861 GAACCAATCA TGTGGCATTT CACATTGAGC ATCATATTTA ATTCTGAAAA AAATCCTTGT 1921 ACTGTATCAT TCTTCATATT TTATGGATGC AGTAACTAAG GCTGAGAACT TTAAAATTTT 1981 TCCTAAGTTC AGACACATAG CTAAGTGGCA GAACCAAGAT TCAAACTCAC CCCATCTAAC 2041 TGCAGAGCAA ACTGCATGCC TTAAATGTCA AAGTGAATAC TAGCACAGTT AATACAATGT 2101 TTGGAAACTC AGAGAAGGAA TGATCCCTCT GCATTATAGT TACTAAGGAA TCATTGCCAT 2161 TATTTAAATG CCAGTGCTTC TACATCAGGC CCAAATTTTC TGTCCTACTA ACTGTGAATC 2221 AAGACTTGAT TCAACCTCTA CTTGAGTATC TGCCGCAATG AGAAATCACT TACCTCCACT 2281 AACCACACAT TTATTTTATA ACAACAGATT GTTAGTAAGT CCTTTCTTAT ACATACTCAA 2341 CAGCTGCTTC CCAAGATGCT GTAGGATTAT GTCTAGAGTC AAACTAGCCA GAAGCAATGT 2401 CCAAAATACA CCATAACACT GTGCAGCAAA GGTCCTACTA CCACTTGTTT GGCCCAAACA 2461 TTCTAGGCAG CACTGGATAT CTGAATCATC AATTATTTCC ACAAACACTG ACCCCTCTAC 2521 CAGTCACCCT CACTAGAAGA ATTAATTCCA CATGATAATA GCTCCCTCAT GTTACTCCCT 2581 TCTAAGTCAA ATTGTACACC CCTTTATCTG ATTAACAGAG TCTAAGTCAC ATGACCTAAA 2641 TGCAAGAGAA CTGGGAATGG ACGTTTGTGG ATTCTACCTT AGTAAGGCAA AGTTATCATT 2701 GGGAATTCCT CTAATACAGG AAGGGTGTTC CAGAGACATT AAGGAGCCAT ATAAATGGAA 2761 AATGTCCACT ACAATCCATC ACTTGGTTGC CCCACATCAA CATTCATTCT TTTGCCACAC 2821 TTAAAGTTTC CAAGAACAAA AATTATCCCA CTGAACATAA TCTTTACTAT CTTTTATATA 2881 AAGGAAAATT AGACTTGACT CAGCAGAACT GAAATAACCC AGCTCTAACA GTTACTGCTT 2941 TTAACTTCAA GTACTGTGTC TCTAGGTGAT ACCTGCTCCA ACAATAGTTT GGTCACATTT 3001 TCAATTTGAT ATTCTCTAGT CTCCCAACTT GATAACTGTA CCCTAAACCA TAAAGTTCAC 3061 TACCAACATG CTATATATAA AATAACCAAA GGGGGAAGAA GAAAGAGAAA AAGGAAATCT 3121 CTTAAAATAC ACAGGTATAC ATATGACAAA GCAAAGAAGG AAATGTGAGC AGATAGTGCA 3181 GTCCTCGTTT CTGAAATTGG TCCCCTGACT GGGGCTATAC CTATTCCATT TCCTCACCCT

3241 CAGCCAGGCA GGTGGAGCAA AAACTTAAGT CTTGGTGGAT CTGAATCTTG ATGCTGTGGA 3301 GCTGTCTTAC TAGCCCCAGA CTACCTGCCT CTCAATTTCT AATTATATCA GTGAAAGCAA

3361 ACAGCTTTGA TTTGTTTAAG CCTCTGATTT TTTGGTCTAA CTGATGTAAG ACCACAAGGA 3421 CAAGAGTTCT CCAGCTCCGG ATTCTCTTCT GTTCTGTTAA TGGTGAAATG CCCGAGAGAA

3481 GAGTTGCCAA CTTTGGCAAA TAAAAAATAC AGGATTCCAG TTAAATTCAA ATTTAGATAA 3541 ACAACAATTT TTTAGTATTA GTGTGTCCCA TTCAATATTT GGACATACTT AACTAAAAAA 3601 TGATTTGTTG TTCATCTGAA ATACAAATTT AACTGGGCAT TCTGAATATT CTCTGGCAAC 3661 CCCCGAGAGA GTGAAGAAAG TGGTACAAGG ACACTTAAGA AGACCAGATT TGAAAAGACA 3721 TTACGGATGT GTTTAAATGT CTTATTCTAG AGAGAGTTAG AGCTGTAGGT AGAACTTGGG 3781 AAATTAAGTT AAAAGCAGAC ACAGAGACCT GGCCAATATA TACTAAGGAG TGGATCACTC 3841 TGGTCACAAG CCCAACCTGA GACCAAGGGC ATAGTGAGAT GATTTGGGAA AGGCACTTAT 3901 ACACTACTCA TCCCCGTCTT TGAACTAAAT GCCTTATAAA TCTCCAAGAG AAATGACAGT 3961 CCACCATGTG GACTGCTTTC TGTAAGTCCA GGGAAAATAA AAGCTATGTG CTTGAAACCC 4021 ACTTCTGATA TTATAAGGTG TGTGATCTTT GTCATGTTAA TGGGTCTGAG TATCAATTCT 4081 ACAATTGTAA AGTGACAGTA ATGGTGTGTC CCCAGGTTGT TGTGGAAAGC TTGATTCTTA 4141 ATGCAACAGT AGGAAACCCC AGCCTCTCTG GAGCAAACAC CCTTCTACAT CTTTACTTCC 4201 CCTGCACATT GGCAGGACTC TATTCCTCTA TTTCTCTCTA GTGCTAGAGC AGAAAGGGAC 4261 CTTGATTTGA TATCAGGAAA ATCTATTTCT GAACCATAAG CTATGATAGC TGATTTAAAA 4321 AATTGACTAT CATGACATGA TAATGATCAT AATGGTAATA CATATTGATA GGGTTGCCGT 4381 GAAAGTAATA ATATATCTAA GAGTTGTGAC AATATATGAT ACGCCTAGAC TCTCAGAAAA 4441 TGCTAATTCC AATCCCAATT GCTCTTTGCA TAAAGTTCTG TCCTAGGGTC TGTTCTTTTC 4501 CCACATCTAC CCTCCTTGGA TCTCTCTTCT GTCTTTTTCA TGTGGTTCAG AGGAGGAGAG 4561 AGATCCAGGT CAATGTTTTT CAAATTACAA GGAATTATCA TTTAAATGGG GAAGAAGCTC 4621 AAGTTTTGAC GTGTAGTGGA ATTGGAGTGG AGTGGAGTGG AATGGAAACT AACAGGAAGA EPI-109 605

4681 CACTGCACAT GGTTAAGATA AAGATTGTTT CCTGAAACCT TTAATTTGTG CTTACATACT 4741 CACACATACA TATGTGCATG CACTGGGACT CTGCAATATG CATTTCTGAC TATGGAACAT 4801 AGCCATAAAA GTCTTTGCAC TGAACGTTCA GTGGGCCTTT CACAAGCTGC CCTAATTGGG 4861 AAAGAAAAAC ATGGTCCCTC CATTTCCTGC CCCCAACTCC AGAAAAGTCA CCATAGTTGA 4921 GGGTACATCT GAGAAGCCAG CACTTGGGAG TTCAGGGCTC AAGTTCCTTT CTAGAAAAAC 4981 ACTGGGTGAT TCTAGGGGAA CTTCCGATCA GAAACAGCCA ATTCAGAGTG AGAGAAGAAA 5041 ACGTGACCAT GCAGTTCCTG TGGTTACCAG CCTTGCCCCT CTCTTGCCTT CTGGGAGTTA 5101 TAAAACCCAA GACTGGAAAG GAAAACCAGC ATTTGCTCAG GCAGCCTCTC TGGGAAGATG 5161 CTGCTTCTTC CTCTCCCCCT GCTGCTCTTT CTCTTGTGCT CCAGAGCTGA AGCTGGTGAG 5221 TATCAGGGTT CTTCCCTCTG AAATCTGCAG TATCAGCTCC TGAAACAAAG ATGTTTAGTC 5281 TGAAATAGCT GACTCCTAAA CAGGGTTCCA AGATCTCTCT TCAAGAGTCC CACAGAGGAA 5341 ATTTCCACTT GGGATGTGTG CCACCCCACC CCCACCCCCA CCCACTGCCA TTCTCTACAG 5401 CCTAGGACAC CCCCAGGAAC AAGGAATTTC ACCTCAATTG TAGAAAAGCC CAGAGCAAGT 5461 GGAAGGAAAA GGGGTATCCC CAGGAAAACA GACATGTCCT CTTAATCTTC TGAGCATCAG 5521 GGCTACCCAT TACTTTGTGA CTTTCTCACT CTGTGACCAT GCTCAAGAGC TATGGAGAAA 5581 TCTAAAACAG GAACCTGGAC AGTGGGTCCT ACACAGAGAC AGAGGAGAGT GGGCCAGGGC 5641 AAGGTGGGAG TGGGAGAAGT CTGAGATGAA AACATCAGAA TGGAGCAGAG GCAAGAATGA 5701 GATTTCACCT GGGAGGTTAT GGGTGGGGAA AGATACGAAA TACAGGAGAC AGGAGAGGGA 5761 AGATGGGCGG AACACAGGGT GAGAATGAGA TTCCAGGGAA GCCTAGCTCA GCTTTAACCC 5821 AATTTGTCCA TTCATTGGAG AGAGTATCTA TGGCCGTGTT CAAACCCTGG GGTGCTCTGT 5881 TCCAGGGGAG ATCATCGGGG GCACAGAATG CAAGCCACAT TCCCGCCCCT ACATGGCCTA 5941 CCTGGAAATT GTAACTTCCA ACGGTCCCTC AAAATTTTGT GGTGGTTTCC TTATAAGACG 6001 GAACTTTGTG CTGACGGCTG CTCATTGTGC AGGAAGGTGA GACAACAGGG TCTATTTATC 6061 TCCAAATGGG AGATGAACAA CCAGAGTAGC ATCCAGGAAT ACACCTGCAC TGGGGACTGA 6121 AGAGGGGGTC CTGGGTCTTG TCAACTTTCA GGAGAGGGAA GACTTTGGGC TGAAAGACTT 6181 TAGTCTGTGT TTGAATAGTT CCTTGAGCCT CAGTCACTGA GCTAAGCTCC CTTCGGAGGA 6241 AAAGGAGGTC CTGTCCGAAG GTCCCTCTTG TTGCAGTAGC ACCCCTCACC CCTACCCAAC 6301 TCAAGACACA CGGCTCACTT TTCAGGGCCC CACCCAGTCT CAGGGCCACT TCCTCTATGG 6361 CCTTTTCAAG AACACTGGCT CTAGTTCTCA GGGTCCTGAA CCCATCATTT TATGGGAGCA 6421 GAGAACAGGT CTACATAAGA CCCCCACTTT CCCGTTTTAA CTGATATCTC CTGCTTCAGG 6481 GGCTGGCCCT CATGCAGGGT TCCCTGAATT AGGAAGTGTG AACCCTGTCC CCTGAGTCCT 6541 CCCTGGCCTG TTCAGTCCCC AGCAATTCCA GGGGTCGTAG AAATTGTGTC TGTTTCCTGA 6601 GAAAGCTCTT TCATGAGTTA AGCCTGAGCC CTCAAATGCC ACAAGTGGCC CATGAAAAGG 6661 GAGATGGGTA GAGTCCGGCN ACCCAGTGAC AGAGTTTAGT CCTCTTTTCT CAGAATGAGC 6721 TCACCTCAGA AGAAACCCCA AGCCATCACT GTCGCCTCCT TTTCCTTCCT TCTTCCTCAC 6781 AGCAGGTCTA TAACAGTCAC CCTTGGAGCC CATAACATAA CAGAGGAAGA AGACACATGG 6841 CAGAAGCTTG AGGTTATAAA GCAATTCCGT CATCCAAAAT ATAACACTTC TACTCTTCAC 6901 CACGATATCA TGTTACTAAA GGTGACAACA CCTCTCTTCT CCCTTTCCAC TTCCCATTCT 6961 CCTAAGCTTC TCCTTCAGGT CCTCATTGCC CTGAATTTTT CTTAGGACTT GGCTATAACA 7021 TGAAGCTACT CACCCTGTCC CTCCCTGATC ACCTCCAACT GTCCAGAGCC CATTTCGAGG 7081 ACTGACAGTC CTTCATTCCC TTCACAGTTG AAGGAGAAAG CCAGCCTGAC CCTGGCTGTG 71 1 GGGACACTCC CCTTCCCATC ACAATTCAAC TTTGTCCCAC CTGGGAGAAT GTGCCGGGTG 7201 GCTGGCTGGG GAAGAACAGG TGTGTTGAAG CCGGGCTCAG ACACTCTGCA AGAGGTGAAG 7261 CTGAGACTCA TGGATCCCCA GGCCTGCAGC CACTTCAGAG ACTTTGACCA CAATCTTCAG 7321 CTGTGTGTGG GCAATCCCAG GAAGACAAAA TCTGCATTTA AGGTGATCCT CCAACTAGGT 7381 TTCCTCTCCA AAACTCACTG TTCAGGGACC TGAATGCTCT TAGAAGGAGA TGGGGTCAGC 7441 AGGTTGTCAG TCAGGTGACA GGGTGAGCAT CACAGGAATT GCTGTCCTCC CGTGGTCCAA 7501 GACAGCCTCT GACCATCCAT TCCAGTCTAC TGCACTGGGG GCATGGGGTG ACTGTGGAGA 7561 ATGTGGATGA CGGTCCCAAG AAAGGAAGAA GGGGCATCAG AACTAGATGT ATAAGTGAGG 7621 AGCTCCACCT CCTGGGTCTG ACTTTAGGTC TCACTGTGAC TCCAAGCTGG CTGGCAGACA 7681 GGAGTGGAGG ACTTCCCGGG CTCACCTTCT TCTCTCTCTC CTCCCCCTAC AGGGAGACTC 7741 TGGGGGCCCT CTTCTGTGTG CTGGGGTGGC CCAGGGCATC GTATCCTATG GACGGTCGGA 7801 TGCAAAGCCC CCTGCTGTCT TCACCCGAAT CTCCCATTAC CGGCCCTGGA TCAACCAGAT 7861 CCTGCAGGCA AATTAATCCT GGATCCTGAG CCAGCCTGAA GGGAAGCTGG AACTGGACCT 7921 TAGCAGCAAA GTGTGTGCAA CTCATTCTGG TTCTACCCTT GGTTCCCTCA GCCACAACCC 7981 TAAGCCTCCA AGAGGTCTCC TACAGGTAAC AGAACTTTCA ATAAACTTCA GTGAAGACAC 8041 AGCTTCTAGT CGTGAGTGTG TGTCCCTCTC TGCTGCTCTC TTCTCCTGCA CATGTGACCT 8101 GATTCCCAGC CCAAGCACCA AGGA

(2) INFORMATION FOR SEQ ID NO:2468: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 661 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2468:

1 ATCATCGGGG GCACAGAATC CAAGCCACAT TCCCGCCCCT ACATGGCCTA CCTGGAAATT

61 GTAACTTCCA ACGGTCCCTC AAAATTTTGT GGTGGTTTCC TTATAAGACG GAACTTTGTG

121 CTGACGGCTG CTCATTGTGC AGGAAGGTCT ATAACAGTCA CCCTTGGAGC CCATAACATA EPI-109 606

181 ACAGAGGAAG AAGACACATG GCAGAAGCTT GAGGTTATAA AGCAATTCCG TCATCCAAAA 241 TATAACACTT CTACTCTTCA CCACGATATC ATGTTACTAA AGTTGAAGGA GAAAGCCAGC 301 CTGACCCTGG CTGTGGGGAC ACTCCCCTTC CCATCACAAT TCAACTTTGT CCCACCTGGG 361 AGAATGTGCC GGGTGGCTGG CTGGGGAAGA ACAGGTGTGT TGAAGCCGGG CTCAGACACT 421 CTGCAAGAGG TGAAGCTGAG ACTCATGGAT CCCCAGGCCT GCAGCCACTT CAGAGACTTT 481 GACCACAATC TTCAGCTGTG TGTGGGCAAT CCCAGGAAGA CAAAATCTGC ATTTAAGGGA 541 GACTCTGGGG GCCCTCTTCT GTGTGCTGGG GTGGCCCAGG GCATCGTATC CTATGGACGG 601 TCGGATGCAA AGCCCCCTGC TGTCTTCACC CGAATCTCCC ATTACCGGCC CTGGATCAAC 661 CAGATCCTGC AGGCAAATTA A

(2) INFORMATION FOR SEQ ID NO: 2469: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1261 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2469:

1 GCCACCATGG AAACCCTTTG CCTCAGGGCA TCCTTTTGGC TGGCACTGGT TGGATGTGTA 61 ATCAGTGATA ATCCTGAGAG ATACAGCACA AATCTAAGCA ATCATGTGGA TGATTTCACC 121 ACTTTTCGTG GCACAGAGCT CAGCTTCCTG GTTACCACTC ATCAACCCAC TAATTTGGTC 181 CTACCCAGCA ATGGCTCAAT GCACAACTAT TGCCCACAGC AGACTAAAAT TACTTCAGCT 241 TTCAAATACA TTAACACTGT GATATCTTGT ACTATTTTCA TCGTGGGAAT GGTGGGGAAT 301 GCAACTCTGC TCAGGATCAT TTACCAGAAC AAATGTATGA GGAATGGCCC CAACGCGCTG

361 ATAGCCAGTC TTGCCCTTGG AGACCTTATC TATGTGGTCA TTGATCTCCC TATCAATGTA 421 TTTAAGCTGC TGGCTGGGCG CTGGCCTTTT GATCACAATG ACTTTGGCGT ATTTCTTTGC

481 AAGCTGTTCC CCTTTTTGCA GAAGTCCTCG GTGGGGATCA CCGTCCTCAA CCTCTGCGCT 541 CTTAGTGTTG ACAGGTACAG AGCAGTTGCC TCCTGGAGTC GTGTTCAGGG AATTGGGATT 601 CCTTTGGTAA CTGCCATTGA AATTGCCTCC ATCTGGATCC TGTCCTTTAT CCTGGCCATT 661 CCTGAAGCGA TTGGCTTCGT CATGGTACCC TTTGAATATA GGGGTGGACA GCATAAAACC 721 TGTATGCTCA ATGCCACATC AAAATTCATG GAGTTCTACC AAGATGTAAA GGACTGGTGG 781 CTCTTCGGGT TCTATTTCTG TATGCCCTTG GTGTGCACTG CGATCTTCTA CACCCTCATG 841 ACTGGTGAGA TGTTGAACAG AAGGAATGGC AGCTTGAGAA TTGCCCTCAG TGAACATCTT 901 AAGCAGCGTC GAGAAGTGGC AAAAACAGTT TTCTGCTTGG TTGTAATTTT TGCTCTTTGC 961 TGGTTCCCTC TTCATTTAAG CCGTATATTG AAGAAAACTG TGTATAACGA GATGGACAAG

1021 AACCGATGTG AATTACTTAG TTTCTTACTG CTCATGGATT ACATCGGTAT TAACTTGGCA

1081 ACCATGAATT CATGTATAAA CCCCATAGCT CTGTATTTTG TGAGCAAGAA ATTTAAAAAT

11 1 TGTTTCCAGT CATGCCTCTG CTGCTGCTGT TACCAGTCCA AAAGTCTGAT GACCTCGGTC

1201 CCCATGAACG GAACAAGCAT CCAGTGGAAG AACCACGATC AAAACAACCA CAACACAGAC

1261 CGGAGCAGCC ATAAGGACAG CATGAACTGA CCACCCTTAG AAGCACTCCT

(2) INFORMATION FOR SEQ ID NO:2470: (l) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 1861 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2470:

1 GAATTCGGGA AAAAGTGAAG GTGTAAAAGC AGCACAAGTG CAATAAGAGA TATTTCCTCA 61 AATTTGCCTC AAGATGGAAA CCCTTTGCCT CAGGGCATCC TTTTGGCTGG CACTGGTTGG 121 ATGTGTAATC AGTGATAATC CTGAGAGATA CAGCACAAAT CTAAGCAATC ATGTGGATGA 181 TTTCACCACT TTTCGTGGCA CAGAGCTCAG CTTCCTGGTT ACCACTCATC AACCCACTAA 241 TTTGGTCCTA CCCAGCAATG GCTCAATGCA CAACTATTGC CCACAGCAGA CTAAAATTAC 301 TTCAGCTTTC AAATACATTA ACACTGTGAT ATCTTGTACT ATTTTCATCG TGGGAATGGT

361 GGGGAATGCA ACTCTGCTCA GGATCATTTA CCAGAACAAA TGTATGAGGA ATGGCCCCAA 421 CGCGCTGATA GCCAGTCTTG CCCTTGGAGA CCTTATCTAT GTGGTCATTG ATCTCCCTAT

481 CAATGTATTT AAGCTGCTGG CTGGGCGCTG GCCTTTTGAT CACAATGACT TTGGCGTATT 541 TCTTTGCAAG CTGTTCCCCT TTTTGCAGAA GTCCTCGGTG GGGATCACCG TCCTCAACCT 601 CTGCGCTCTT AGTGTTGACA GGTACAGAGC AGTTGCCTCC TGGAGTCGTG TTCAGGGAAT 661 TGGGATTCCT TTGGTAACTG CCATTGAAAT TGTCTCCATC TGGATCCTGT CCTTTATCCT 721 GGCCATTCCT GAAGCGATTG GCTTCGTCAT GGTACCCTTT GAATATAGGG GTGAACAGCA 781 TAAAACCTGT ATGCTCAATG CCACATCAAA ATTCATGGAG TTCTACCAAG ATGTAAAGGA 841 CTGGTGGCTC TTCGGGTTCT ATTTCTGTAT GCCCTTGGTG TGCACTGCGA TCTTCTACAC 901 CCTCATGACT TGTGAGATGT TGAACAGAAG GAATGGCAGC TTGAGAATTG CCCTCAGTGA 961 ACATCTTAAG CAGCGTCGAG AAGTGGCAAA AACAGTTTTC TGCTTGGTTG TAATTTTTGC

1021 TCTTTGCTGG TTCCCTCTTC ATTTAAGCCG TATATTGAAG AAAACTGTGT ATAACGAGAT 1081 GGACAAGAAC CGATGTGAAT TACTTAGTTT CTTACTGCTC ATGGATTACA TCGGTATTAA 1141 CTTGGCAACC ATGAATTCAT GTATAAACCC CATAGCTCTG TATTTTGTGA GCAAGAAATT 1201 TAAAAATTGT TTCCAGTCAT GCCTCTGCTG CTGCTGTTAC CAGTCCAAAA GTCTGATGAC 1261 CTCGGTCCCC ATGAACGGAA CAAGCATCCA GTGGAAGAAC CACGATCAAA ACAACCACAA EPI-109 607

1321 CACAGACCGG AGCAGCCATA AGGACAGCAT GAACTGACCA CCCTTAGAAG CACTCCTCGG 1381 TACTCCCATA ATCCTCTCGG AGAAAAAAAT CACAAGGCAA CTGTGAGTCC GGGAATCTCT 1441 TCTCTGATCC TTCTTCCTTA ATTCACTCCC ACACCCAAGA AGAAATGCTT TCCAAAACCG 1501 CAAGGGTAGA CTGGTTTATC CACCCACAAC ATCTACGAAT CGTACTTCTT TAATTGATCT 1561 AATTTACATA TTCTGCGTGT TGTATTCAGC ACTAAAAAAT GGTGGGAGCT GGGGGAGAAT 1621 GAAGACTGTT AAATGAAACC AGAAGGATAT TTACTACTTT TGCATGAAAA TAGAGCTTTC 1681 AAGTACATGG CTAGCTTTTA TGGCAGTTCT GGTGAATGTT CAATGGGAAC TGGTCACCAT 1741 GAAACTTTAG AGATTAACGA CAAGATTTTC TACTTTTTTT AAGTGATTTT TTTGTCCTTC 1801 AGCCAAACAC AATATGGGCT CAAGTCACTT TTATTTGAAA TGTCATTTGG TGCCAGTATC 1861 CCGAATTC

(2) INFORMATION FOR SEQ ID NO: 2471: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2581 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2471:

TACCAGTCCA AAAGTCTGAT GACCTCGGTC CCCATGAACG GAACAAGCAT CCAGTGGAAG AACCACGATC

AAAACAACCA CAACACAGAC CGGAGCAGCC ATAAGGACAG CATGAACTGA CCACCCTTAG AAGCACTCCT

GAATTCGGGA AAAAGTGAAG GTGTAAAAGC AGCACAAGTG CAATAAGAGA TATTTCCTCA AATTTGCCTC

AAGATGGAAA CCCTTTGCCT CAGGGCATCC TTTTGGCTGG CACTGGTTGG ATGTGTAATC AGTGATAATC

CTGAGAGATA CAGCACAAAT CTAAGCAATC ATGTGGATGA TTTCACCACT TTTCGTGGCA CAGAGCTCAG

CTTCCTGGTT ACCACTCATC AACCCACTAA TTTGGTCCTA CCCAGCAATG GCTCAATGCA CAACTATTGC

CCACAGCAGA CTAAAATTAC TTCAGCTTTC AAATACATTA ACACTGTGAT ATCTTGTACT ATTTTCATCG

TGGGAATGGT GGGGAATGCA ACTCTGCTCA GGATCATTTA CCAGAACAAA TGTATGAGGA ATGGCCCCAA

CGCGCTGATA GCCAGTCTTG CCCTTGGAGA CCTTATCTAT GTGGTCATTG ATCTCCCTAT CAATGTATTT

AAGCTGCTGG CTGGGCGCTG GCCTTTTGAT CACAATGACT TTGGCGTATT TCTTTGCAAG CTGTTCCCCT

TTTTGCAGAA GTCCTCGGTG GGGATCACCG TCCTCAACCT CTGCGCTCTT AGTGTTGACA GGTACAGAGC

AGTTGCCTCC TGGAGTCGTG TTCAGGGAAT TGGGATTCCT TTGGTAACTG CCATTGAAAT TGTCTCCATC

TGGATCCTGT CCTTTATCCT GGCCATTCCT GAAGCGATTG GCTTCGTCAT GGTACCCTTT GAATATAGGG

GTGAACAGCA TAAAACCTGT ATGCTCAATG CCACATCAAA ATTCATGGAG TTCTACCAAG ATGTAAAGGA

CTGGTGGCTC TTCGGGTTCT ATTTCTGTAT GCCCTTGGTG TGCACTGCGA TCTTCTACAC CCTCATGACT

TGTGAGATGT TGAACAGAAG GAATGGCAGC TTGAGAATTG CCCTCAGTGA ACATCTTAAG CAGCGTCGAG

AAGTGGCAAA AACAGTTTTC TGCTTGGTTG TAATTTTTGC TCTTTGCTGG TTCCCTCTTC ATTTAAGCCG

TATATTGAAG AAAACTGTGT ATAACGAGAT GGACAAGAAC CGATGTGAAT TACTTAGTTT CTTACTGCTC

ATGGATTACA TCGGTATTAA CTTGGCAACC ATGAATTCAT GTATAAACCC CATAGCTCTG TATTTTGTGA

GCAAGAAATT TAAAAATTGT TTCCAGTCAT GCCTCTGCTG CTGCTGTTAC CAGTCCAAAA GTCTGATGAC

CTCGGTCCCC ATGAACGGAA CAAGCATCCA GTGGAAGAAC CACGATCAAA ACAACCACAA CACAGACCGG

AGCAGCCATA AGGACAGCAT GAACTGACCA CCCTTAGAAG CACTCCTCGG TACTCCCATA ATCCTCTCGG

AGAAAAAAAT CACAAGGCAA CTGTGAGTCC GGGAATCTCT TCTCTGATCC TTCTTCCTTA ATTCACTCCC

ACACCCAAGA AGAAATGCTT TCCAAAACCG CAAGGGTAGA CTGGTTTATC CACCCACAAC ATCTACGAAT

CGTACTTCTT TAATTGATCT AATTTACATA TTCTGCGTGT TGTATTCAGC ACTAAAAAAT GGTGGGAGCT

GGGGGAGAAT GAAGACTGTT AAATGAAACC AGAAGGATAT TTACTACTTT TGCATGAAAA TAGAGCTTTC

AAGTACATGG CTAGCTTTTA TGGCAGTTCT GGTGAATGTT CAATGGGAAC TGGTCACCAT GAAACTTTAG

AGATTAACGA CAAGATTTTC TACTTTTTTT AAGTGATTTT TTTGTCCTTC AGCCAAACAC AATATGGGCT

CAAGTCACTT TTATTTGAAA TGTCATTTGG TGCCAGTATC CCGAATTC

(2) INFORMATION FOR SEQ ID NO: 2472: (i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 361 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2472: 1 GCTCAGCCTC CAAAGGAGCC AGCCTCTCCC CAGTTCCTGA AATCCTGAGT GTTGCCTGCC 61 AGTCGCCATG AGAACTTCCT ACCTTCTGCT GTTTACTCTC TGCTTACTTT TGTCTGAGAT 121 GGCCTCAGGT GGTAACTTTC TCACAGGCCT TGGCCACAGA TCTGATCATT ACAATTGCGT 181 CAGCAGTGGA GGGCAATGTC TCTATTCTGC CTGCCCGATC TTTACCAAAA TTCAAGGCAC 241 CTGTTACAGA GGGAAGGCCA AGTGCTGCAA GTGAGCTGGG AGTGACCAGA AGAAATGACG 301 CAGAAGTGAA ATGAACTTTT TATAAGCATT CTTTTAATAA AGGAAAATTG CTTTTGAAGT 361 AT

(2) INFORMATION FOR SEQ ID NO: 2473: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4621 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2473: EPI-109 608

1 ATCCTTTAAG TCAATGGACT TTGCATCAGT CACACCATCT TTTGTTACTT TGGACTTCCC

61 CAGCTATGTT CAATAATTAC TGTTCTTCCC TTGGGCCCCA TTGTAATGGC TACAGCCTCG

121 ACAAAAAGTC TACACTTTGA AGCATTAAGG CTCGGACATC AGCACCAAAT TTTACATCTT

181 TACCATCACT TCAAGTGAGG TGAGGAGCCA GTAGCCTGGA CACTGGTCTC ATCTGGTGAA

241 AGACTGTGGG TAATGGAAGC ATTTCTGTGG GGTGCTGGCA GGACATGTGC ATGGCGAGGC

301 AGGTCATCAG CAGCAAGTGA GAGCTGCCTC TTACTTTCTA AAGGTGACAT AGCAAATATA

361 CAAAAAAAAA TAAATAAATT ATTAATTTAG GTAGAGCACA TAAAGGCTTT ATTTCATATT

421 CCATTTCTCT GTATGCTTTC TTCACCAGGA AGAAATAGTT TTAGTGTCAG GAATGAATGA

481 GTCTGCCCCT CAATTCCAGC CTGCTCAACA CACAAGGAAA CAAAGCCCTG ACAATCAGAG

541 TGACTCCCTG GTGACTAAGC TCCCAGTCCT GGATGCATAT TTGTTTAGCA GTTCTGACAG

601 CATTTGACCC AGCCCTCTCT CTGCATATCC CATCAGAACC TTCTTTTTTT TTTTTTTCTT

661 TGAGACTGAG TCTTGCTCTG TCGGAAGCGA CTCCTGTGCC TCAGCCTCCC AAATACCTGG

721 AATTATAGGC GTAAGCCATC ATGCCTGGCT AATTTTTGTA TTTTTCATGG AGATGGGGTT

781 TTGCCATGTT GGTCAAATTG GTCTCACACT CCTGACCTCA TGTGATCCAC CTGCCTCAGC

841 CTCCCAAACT GCTGGGATGA CAGGTGTAAG CCACCATGCT AGGCTCAGAA ATTTCCTTTT

901 ATAAAAATGT CATTAAGGAT CTTGGCTGCA CAATATCGTT ACCAGCTTCC TTTAAATCCA

961 CTTCTGGCCT GCCAGGAATC AGGTTCTTCA GAACCTGACA TTTTAAATGA AGAGGTCAGG

1021 CAGTTCATGA GGAAAGCCTC ATTGTCCCCA TGTCTCTGTC ACTGCTGCAC CCCTGAGACA

1081 TCACAGACAT GGACACTGGG GCCTGCTTGT TTCTCAAACT GCCCTTAGAT CGAAAGAGGG

1141 AGGAACCAGG ATGAATGCCA CTCATTTTCC CAAGAAAGGC CCTCTCCTGA GTGCCCGGGA

1201 TGGGGCTCTG TCCATTGCCT GGGGCCGCCA ATTGCTACTC TGGGTTACGG AGGAAGGACA

1261 GGGTCCTGAG AGACACCAGA GACCTCACAC AGCCCTGAAA ACATGGGGCT CCTTCATAAG

1321 TGTTTCCCAT CACCAACAGG GAGACCACGT GGAGGCCTTG CAGCCCCACT CGGTGCTTCT

1381 CCACCAAATC CCAAGGGCAG TGACGCTGAC GTCTGTGGAA AGCAGAGAAA GCCCTGGCTC

1441 CCAAAGCCCT GAAGTCCCTG TGGAGCTGAC ATTCCCTGAG TGACGGTGTG AATGGAAGGA

1501 ACTCAAGTGC GGGTGGTAGG CCACCTCCTG GCCCAGGCCT GGGTGAACTC TGAGGGGACA

1561 CATGTAGTCA CAATCCCATC CTCCCATTCT CCTTCTCAGA GGAAGGAAGT GGGCATCCAT

1621 CTGCCTCATC TCTCTCCCGT GGGGAAGATG GGGAGTTTCA GGGGAACTTT CACATAAATT

1681 TCACCAGCTC AGATCTCCTG TGAGGATGGG GCCCACCATG CTCCCGGTGC TGCCAGAGGC

1741 CCTGAGCCCC TCCCAGGGTC CCTGGGTTTG AGCCAGCCCT GTATCATCCC CAGGAGCTGA

1801 ATGTCAGAGC AATGGATAGA ATTAGATGGA AAGAGCTCTC AATTTGACCT GAGACTGTCC

1861 CCAGATACTC AGGAAAAACA GGACGTCGCA CAGAGTGGGC AGCAGGTGAG TGGCAGGTTA

1921 TAGGTCCTGA GTTTGAGTTT GTTCTCACGT GAGACAGACC CAGCCCCTCA CTCCATTCAC

1981 ACACTGGGTT TTAAATGGTG CAAGATAGGA GCAATTTTCT GGTCCCAAGA GCAGGAGGAA

2041 GGGATTTTCT GGGGTTTCCT GAGTCCAGAT TTGCATAAGA TCTCCTGAGT GTGCATTGTT

2101 CTTTGAGGAC CATTCTCTGA CTCACCAGGT AAGTGGCTGA ATTCTAACCT CTGTAATGAG

2161 CATTGCACCC AATACCAGTT CTGAACTCTA CCTGGTGACC AGGGACCAGG ACCTTTATAA

2221 GGTGGAAGGC TTGATGTCCT CCCCAGACTC AGCTCCTGGT GAAGCTCCCA GCCATCAGCC

2281 ATGAGGGTCT TGTATCTCCT CTTCTCGTTC CTCTTCATAT TCCTGATGCC TCTTCCAGGT

2341 GAGATGGGCC AGGGAAATAG GAGGGTTGGC CAAATGGAAG AATGGCGTAG AAGTTCTCTG

2401 TCTCCTCTCA TTCCCCTCCA CCTATCTCTC CCTCATCCCT CTCTCTCCTT CCTCTCTCTG

2461 TGTGTCCCCT CCATCCTTTT CTCCTGCTTC TCTCTCTTCT TCCCTCTCTC TCTTTTTTCT

2521 GTCTTTCTTT TTCCTCTCTC CCTAGAGCAT GTCTTTCTTT CTTTCTCTTT CCTTTCTTCT

2581 ACCCACACTT TTAGACTGAA TGCCCTATTT AATTGAACAA AGCATTGCTT CCTTCAATAG

2641 AAAAGGAGTT TGAGAACCCA ATGGACACCT CACTCGTTCT TCTAAGCCAA TATGAAGGAG 2701 CCCAGTAGCT TGTAAATATC ATCTCTTCAC TGCTTTCCAT GCTACAACTG CTGAGACTAT 2761 GGTTGAAACC TGTTAGGTGA CTTTTTAAAT AAAAGGCAGA AATTTTGATT TTATCTAAAG 2821 AAAGTAGTAT AGAATGTCAT TTTCTAAATT TTTATATTTA AAGGGTAGAT ACTGCAACCT 2881 AGAGAATTCC AGATAATCTT AAGGCCCAGC CTATACTGTG AGAACTACTG CAGCAAGACA 2941 CTCTGCCTCC AGGACTTTTC TGATCAGAGG CCCTGAGAAC AGTCCCTGCC ACTAGGCCAC 3001 TGCAGGTTCA CAGGACAGGG TACAGCCCAT TGAAACCTAC TTTTAAACCT GGATGCCTAA 3061 CCTTCATTTT CTCCTTGATA TTATGAAAAT AAAATAAAAA CCATGAAAGG ATAAAAGAGG 3121 GAGAGTGGAA GGGAAGGATG GAGAAAGGGA AAAAGAAAAT TTGAGAGTAA ATCCTAAAAC 3181 AATTAATCTA ATAGATATCA TCTTGTGAAA TCCTCATTTT ACCAATCTTA TTTATGAGTC 3241 CTGGGTTTTG TGAGAACAAT GGGGTTCTGA GAGGCACCAG AGACCTCATG TTTTCCAAAA 3301 CCTAGAACAG TATAATGAAG GAAGGCGGGG AGGCAGGGAG GCAGGGAGGC AGGGAGGCAG 3361 GGAGGCGGGC AGGTGGGGAG GGAGGGACGG AAGGAGGGAG GGAGGGAGGG AGGGAGGGAG 3421 GGAGGGATAA AAAAAGAAGA ATGAGGTTGA AACCAGGACT TAGATATTAG AAACAAGCCA 3481 TTACAAAATT TATTTCTATG GTTAATTGTG GTTTTCAACT GTAAGTTACT TGGTGTTAAT 3541 TTCCTATTAA ACAATTTCAG TAAGTTGCAT CTTTTTATCC CATCTCAGGT CAAATACTTA 3601 ACAGACTAAA TGATTTGAAA AAGCAAAAGT TTACTGGCTT GTGTGTGTTA AAATGGAGGT 3661 ATGGTGGCTT TGATATTATC TTCTTGTGGT GGAGCTGAAT TCACAAGAGA TCGTTGCTGA 3721 GCTCCTACCA GACCCCACCT GGAGGCCCCA GTCACTCAGG AGAGATCAGG GTCTTTCACA 3781 ATCAGGTTCT ACAAAAATAA ACATCCCCCC AACCACAGCA GTGCCAGTTT CCATGTCAGA 3841 AACTTAGATC CAAATGACTG ACTCGCGTCT CATTATCATG ATGGAAAAGC CCAGGCTTGA 3901 GAAAGAAGCC CGCTGCGGAT TTACTCAAGG CGATACTGAC ACAGGGTTTG TGTTTTTCCA

3961 ACATGAGTTT TGAGTTCTTA CACGCTGTTT GCTCTTTTTG TGTGTTTTTT CCCTGTTAGG 4021 TGTTTTTGGT GGTATAGGCG ATCCTGTTAC CTGCCTTAAG AGTGGAGCCA TATGTCATCC EPI-109 609

4081 AGTCTTTTGC CCTAGAAGGT ATAAACAAAT TGGCACCTGT GGTCTCCCTG GAACAAAATG

4141 CTGCAAAAAG CCATGAGGAG GCCAAGAAGC TGCTGTGGCT GATGCGGATT CAGAAAGGGC

4201 TCCCTCATCA GAGACGTGCG ACATGTAAAC CAAATTAAAC TATGGTGTCC AAAGATACGC

4261 AATCTTTATC CTAGTAATTG TGGTCATTGG GTGATGTTGG TTTGGGCAGG CCATCTCTAA

4321 TATCCTTGAA ACACCTTTTT CTGCTCTCCA GGAAGGGGTC AGGGCTGCCA CAGCGGGGCT

4381 TGGAGTGCTT TCCAGGGTCA CAGGCATCTG TATTCTTTGG ATTCCTTGAC CTTCCCCATT

4441 TATTCCCGGC ATTTTCCTAA AACGTGTGCT TTGCTCCTCC TGCATCCTCC CCTTGCATGC

4501 CCTCACCTAC CCCACATCTT CCCTAAAAAA AGCAAGCCCA ACTCAAAGAC CAGTTCCCTC

4561 ATGGAATCAT AGTGGATCTG CCAAGGGAGG GGATGCCCAG TCCTCTGTTC TTCACAAGAC

4621 TCCCTTCTTC TGGCTAAGGT TTCTTATGCA ATTAT

(2) INFORMATION FOR SEQ ID NO:2474: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1981 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2474:

1 CTGCAGTGGT AAAAAGATTC TATATCTGCT GTTTGATGAA TGCAGCACCC ACTAGCCACA

61 TAGTGCTCGT GAGCACTTGC AATGCGGCTA GGGTGATTTC AATTAACCTA AAAGAGAACA

121 GCCACAGGGA GCATGTGGCT GCCATATTGG ATGGTGCTGC TTTGAGAACA AAATGAGAGA

181 AATGAAGCCT CTATTTACCT TGGTTGGCGG AACACATTGA AGGGACTCTG TATTGATACC

241 AGGCTTCAAA CTTTGGGAAG TGTACTGGCC AACTTAAACA CATCCACAGG AGAATGAAGA

301 GGTTTGGGAA GGGACCAGAA ACCAGGCATT GAGGACAATG AGAAGAGTTT TTCAAAAGTG

361 GAATTACTGC AAAAAGTGGA AAAATAGCCT TTGGATGGAA GTTACTGATG AGACAATTTC

421 CATCGGTGTG AAAGCCATCT TTCCAACAGA GATCTGCAAC ATGAGAATGT ACTGTCTCCT

481 AGGGTAGCGA TGGCCTCTTG TATTAGTCCG CTCAGGCTAC CAGATTTATC GTTTAAACTG

541 CCCATAAACA GACCAGGCAG TTTAAACAAC AGAAATTTAT TTCCTCGCAG TCCTGGAGGC

601 AGGAAGTCTG CGATCAAGGT GGAAGCAGGG TTGGCTTCTT CTCAGGTGTC TGTCCTTGGC

661 TGGTAGATGA CCGCCGCCTC CCTGGGTCCT CACATGGTCT TTCCTCTGTG TGTGTCTGTC

721 CCAATCTCTT CTTATAAGGA TGCAAGTCTT ATGGATCAGA GCACACCCCA ATGACCGTGT

781 TTAACTTGAA TCACCTCTTT AAAGTTTCTC TCTCCAAATA CAATCACCTC CTGAGGCACT

841 GTTAGGGCTT CGACACAGGA ATTCTTTTCC TAGGGGATTC AGTTCAGTCC AAAACGCCTA

901 CCAGTGGAGA CTTGCAACAT GGCGGCCTGC TGGTCCCTCG CCAGGAATAT CACAGGCGAC

961 TGTTCCCTGT TGCATGGAAT AGAAGGCTAT TCCAGAGTAC TGTCTCTATT TATCAGATCT

1021 GGGATACTGG GAGAAGGGCA AAATAAAGTC CAAGTAGAAA AAAAAACTAT GAAAGTTTTA

1081 GAGAGTAACC ATAATTTCAG CCCGATGTGA AACGATCCTA GATTTCAGCT GAAATAGTGA

1141 TGTGGGAAGT GAGGGGGCCG GGATTCAAGG CAGAGGGAAC AGCGTAACTG AAGGCATGGA

1201 AGGAGGGAAG TGTAGGCTGT GTTTGAAGAG TGGCAGCTGC TTCCACATTT CTAAAACACA

1261 GGATGTGATT TTGGGGTGTG TTGAGACAAG GCAGAAAACT TGTTTGGAAA AATAACTTGA

1321 ATTCCCTGCA CATTTAAAAT CTCTCAGCAG AAGAAAACCC CACTCAGAAC CCCACTGTTC

1381 ATTCCTTGGC TTGTATTTGG SCACAGCTGG CATAGCCCCA GACTGAGTAA GCTCTTCAGA

1441 CACCTCATTT CATGAGTAGC CCCAAAGATC AATCATGGGC CAATTTCTTG GAAGAGAAGA

1501 CTCTCCGGTG TTTTGCAGTT ATTTGTTCTG CTTTCGCGAG ATGTTCTCAA ATCGTTGCAG

1561 CTACAAGCCA TGAGTCTGAA GTGTTTGTGT TCCCTCCTTA CAGGTGGTAA CTTTCTCACA

1621 GGCCTTGGCC ACAGATCTGA TCATTACAAT TGCGTCAGCA GTGGAGGGCA ATGTCTCTAT

1681 TCTGCCTGCC CGATCTTTAC CAAAATTCAA GGCACCTGTT ACAGAGGGAA GGCCAAGTGC

1741 TGCAAGTGAG CTGAGAGTGA CCAGAAGAAA TGACGCAGAA GTGAAATGAA CTTTTTATAA

1801 GCATTCTTTT AATAAAGGAA AATTGCTTTT GAAGTATACC TCCTTTGGGC CAAAATGAAT

1861 CTTGTGTCTC AATTGGAAGA GGTAAAGAAG TAGGGGGTTA GGGTGCATGG GTTGGAACGT

1921 GAGACAGGTC GAACCACAAA GCCTGCCTGG AAAAGGGGAG TGACGTCCTA GGCTTCAGTG

1981 ATGTCACCTC CACTTTGTTT GATCCACAAA CCAACAGGTG ACTGATTTTG

(2) INFORMATION FOR SEQ ID NO: 2475: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 301 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2475:

1 GTCAGCTCAG CCTCCAAAGG AGCCAGCCTC TCCCCAGTTC CTGAAATCCT GAGTGTTGCC

61 TGCCAGTCGC CATGAGAACT TCCTACCTTC TGCTGTTTAC TCTCTGCTTA CTTTTGTCTG

121 AGATGGCCTC AGGTGGTAAC TTTCTCACAG GCCTTGGCCA CAGATCTGAT CATTACAATT

181 GCGTCAGCAG TGGAGGGCAA TGTCTCTATT CTGCCTGCCC GATCTTTACC AAAATTCAAG

2 1 GCACCTGTTA CAGAGGGAAG GCCAAGTGCT GCAAGTGAGC TGGGAGTGAC CAGAAGAAAT

301 GACGCAGAAG TGAAATGAAC TT

(2) INFORMATION FOR SEQ ID NO:2476: (l) SEQUENCE CHARACTERISTICS: (A) LENGTH: 4741 base pairs EPI-109 610

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2476:

1 GAATTCACAT TTCTCACCTT TTGATGTATT AAGAAAGTAT GGAGAAATAT ATCCTCTATC

61 AAATTTTCAT GCCTTCAATA ATTTCTAATT CATCAGTCAG TGTTTTTCCA TCCTTTACTG

121 TGATGATGCC CTTTCTTCCA AACTTTTTCA TTGCATCAGA GATGATGTTA CCAATTTCTT

181 TGTCTCCATT TGCAGAAATT GTAGCAACCT GTGCAATTTC TTCAGGTTTG GTCACAGGTT

241 TAGACTGCTT TTTAAGTTCA GCAATTACAG CATCAACAGC TAACATCACA CCTCTCTTGA

301 TTTCCACTGG ATTAGCACCT TTGCTAACCT TCTGGAAGGC TTATTTGGAA ATAGAGCATA

361 CCAGTACAGC AGCAGTGATA GTGCCATCCC CCAGTCTCTC CATTTGTGTT ATTGGCAACA

421 TCTTGGACAA GTTTAGCTCC AATGCTTTTA TATTTATCCT TTAAGTCAAT TGACTTTGCA

481 TCAGTCACAC CATCTTTTGT TACTTTGGGA CTTCCCCAGC TATGTTCAAT AATTACTGTT

541 CTTCCCTTTG GCCCCATTGT AATGGCTACA GCATCGACAA AAAGTCTACA CTTTGAAGCA

601 TTAAGGCTCA GACATCAGCA CCAAATTTTA CATCTTTACC ATCACTTCAA GTGAGGTGAG

661 GAGCCAGTAG CCTGGACACT GGTCTCATCT GGTGAAAGAC TGTGGGTAAT GGAAGCATTT

721 CTGTGGGGTG GTGGCAGGAC ATGTGCATGG TGAGGCAGGT CATCAGCAGC AAGTGAGAGC

781 TGCCTCTTAC TTTCTAAAGG TGACATAGCA AGTATACAAA AAAAAATAAA ATATTAATTT

841 AGGCAGAGCA CATAAAGGCT TTATTTCATA TTCCATTTCT CTGTATGCTT TCTTCACCAG

901 GAAGAAATAG TTTTAGTGTC AGGAATGAAT GAGTCTGCCC CTCAATTCCA GCCTGCTCAG

961 CACACAAGGA AACAAAGCCC TGACAATCAG AGTGACTCCC TGGTGACTAA GCTCCAGTCC

1021 TGGATGCATA TTTGTTTAGC AGTTCTGACA GCATCTGACC CAGCCCTCTC TTTGCATACC

1081 CCACCAGAAC CTTCTTTTTT TTTTTTTTTC TTTGAGACTG AGTCTTGCTC TGTCGGAAGC

1141 GATTCCCGTG CCTCAGCCTC CCAAATACCT GGAATTATAG GCGTAAGCCA TCATGCCTGG

1201 CTAATTTTTG TATTTTTCAT GGAGATGGGG TTTTGCCATG TTGGTCAAAT TGGTCTCACA

1261 CTCCTGACCT CATGTGATCC ACCTGCCTCA GCCTCCCAAA GTGCTGGGAT GACAGGTGTA

1321 AGCCACCATG CTAGGCTCAG AAATTTCCTT TTATAAAAAT GTCATTAAGG ATCTTGGCTG

1381 CACAATATCG TTACCAGCTT CCTTTAAATC CACCTCTGGC CTGCCAGGAA TCAGGGTTCT

1441 TCAGAACCTG ACATTTTAAA TGAAGAGGTC AGGCAGGTCA TGAGGAAAGC CTCATTGTCC

1501 CCATGTCTCT GTCACTGCTG CACCCCTGAG ACATCACAGA CATGGACACT GGGGCCTGCT

1561 TGTTTCTCAA ACTGCCCTTA GATCGAAAGA GGGAGGAACC AGGATGAATG CCACTCATTT

1621 TCCCAAGAAA GGCCCTCTCC TGAGTGCCCG GGATGGGGCT CTGTCCATTG CCTGGGGCCG

1681 CCAATTGCTA CTCTGGGTTA CGGAAGAAGG ACAGGGTCCT GAGAGACACC AGAGACCTCA

1741 CACAGCCCTG AAAACATGGG GCTCCTTCAT AAGTGTTTCC CATCACCAAC AGGGAGACCA

1801 CGTGGAGGCC TTGCAGCCCT ACTCGGTGCT TCTCCACCAA ATCCCAAGGG CAGTGACGCT

1861 GACGTCTGTG GAAAGCAGAG AAAGCCCTGG CTCCCAAAGC CCTGAAGTCC TGTGGAGCTG

1921 ACATTCCCTG AGTGACGGTG TGAATGGAAG GAACTCAAGT GCGGGTGGTA GGCCACCTCC

1981 TGGCCCAGGC CTGGGTGAAC TCTGAGGGGA CACATGTAGT CACAATCCCA TCCTCCCATT

2041 CTCCTTCTCA GAGGAAGGAA GTGGGCATCC ATCTGCCTCA TCTCTCTCCC GTGGGGAAGA

2101 TGGGGAGTTT CAGGGGAACT TTCACATAAA TTTCACCAGC TCAGATCTCC TGTGAGGATG

2161 GGGCCCACCA TGCTCCCGGT GCTGCCAGAG GCCCTGAGCC CCTCCAGGGT CCCTGGGTTT

2221 GAGCCAGCCC TGTATCATCC CCAGGAGCTG AATGTCCGAA CAATGGATAG AATTAGATGG

2281 AAAGAGCTCT CAATTTGGCC TGAGACTGTC CCCAGATACT CAGGAAAAAC AGGACGTCGC

2341 ACAGAGTGGG CAGCAGGTGA GTGGCAGGTT ATAGGTCCTG AGTTTGAGTT TGTTCTCACG

2401 TGAGACAGAC CCAGCCCCTC ACTCCATTCA CACACTGGGT TTTAAATGGT GCAAGATAGG

2461 AGGAATTTTC TGGTCCCAAG AGCAGGAGGA AGGGATTTTC TGGGGTTTCC TGAGTCCAGA

2521 TTTGCATAAG ATCTCCTGAG TGTGCATTGT TCTTTGAGGA CCATTCTCTG ACTCACCAGG

2581 TAAGTGGCTG AATTCTAACC TCTGTAATGA GCATTGCACC CAATACCAGT TCTGAACTCT

2641 ACCTGGTGAC CAGGGACCAG GACCTTTATA AGGTGGAAGG CTTGATGTCC TCCCCAGACT

2701 CAGCTCCTGG TGAAGCTCCC AGCCATCAGC CATGAGGGTC TTGTATCTCC TCTTCTCGTT

2761 CCTCTTCATA TTCCTGATGC CTCTTCCAGG TGAGATGGGC CAGGGAAATA GGAGGGTTGG

2821 CCAAATGGAA GAATGGCGTA GAAGTTCTCT GTCTCCTCTC ATTCCCCTCC ACCTATCTCT

2881 CCCTCATCCC TCTCTCTCCT TCCTCTCTCT GTGTGTCCCC TCCATCCTTT TCTCCTGCTT

2941 CTCTCTCTTC TTCCCTCTCT CTCTTTTTTT CTGTCTTTCT TTTTCCTCTC TCCCTAGAGC

3001 ATGTCTTTCT TTCTTTCTCT TTCCTTTCTT CTACCCACAC TTTTAGACTG AGTAGACTGA

3061 ATGCCCTATT TAATTGAACC AAGCATTGCT TCCTTCAATA GAAAAGGAGT TTGAGAACCC

3121 AATGGACAAC TCACTCGTTC TTCTAAGCCA ATATGAAGGA GCCCAGTAGT TTGTAAATAT

3181 CATCTCTTCA CTGCTTTCCA TGCTACAACT GCTGAGACTA TGGTTGAAAC CTGTTAGGTG

3241 ACTTTTTAAA TAAAAGGCAG AAATTTTGAT TTTATCTAAA GAAAGTAGTA TAGAATGTCA

3301 TTTTCTAAAT TTTTATATTT AAAGAGTAGA TACTGCAACC TAGAGAATTC CAGATAATCT

3361 TAAGGCCCAG CCTATACTGT GAGAACTACT GCAGCAGACA CTCTGCCCCC AGGACTTTTC

3421 TGATCAGAGG CCCTGAGAAC AGTCCCTGCC ACTAGGCCAC TGCAGGTTCA CAGGACAGGG

3481 ACAGCCCATT GAAACCAACT TTTAAACCTG GATGCCTAAC CTTCATTTTC TCCTTGATAT

3541 TATGAAAATA AAATAAAAAC CATGAAAGGA TAAAAGAGGG AGAGTGGAAG GGAAGGATGG

3601 AGAAAGGGAA AAAGAAAATT TGAGAGTAAA TCCTAAAACA ATTAATCTAA TAGATATCAT

3661 CTTGTGAAAT CCTCATTTTA CCAATCTTAT TTATGAGTCC TGGGTTTTGT GAGAACAATG

3721 GGGTTCTGAG AGGCACCAGA GACCTCATAT TTTCCAAAAC CTAGAACAGT ATAATGAAGG

3781 AAGGAGGGAA GGAGGGAGGG AGGGAGGGAA GGAGGGAAGG AGGGAGGGAG GGAGGGAAAC

3841 AAAAAGAAGA ATGAGGTTGA AACCAGGACT TAGATATTAG AAACAAGCCA TTACAAAATT EPI-109 611

3901 TATTTCTATG GTTAATTGTG GTTTTCAACT GTAAGTTACT TGGTGTTAAT TTCCTATTAA

3961 ACAATTTCAG TAAGTTGCAT CTTTTTTATC CCATCTCAGA TCAAATACTT AACAGACTAA

4021 ATGATTTGAA AAAGCAAAAG TTTACTGGCT TGTGTGTGTT AAAATGGAGG TATGGTGGCT 4081 TTGATATTAT CTTCTTGTGG TGGAGCTGAA TTCACAAGAG ATCGTTGCTG AGCTCCTGCC 4141 AGACCCCACC TGGAGGCCCC AGTCACTCAG GAGAGATCAG GGTCTTTCAC AATCAGGTTC 4201 TACAAAAATA AACATCCCCC AAACCACAGC AGTGCCAGTT TCCATGTCAG AAACTTAGAT 4261 CCAAATGACT GACTCGCGTC TCATTATCAT GATGGAAAAG CCCAGGCTTG AGAAAGAAGC 4321 CCGCTGCGGA TTTACTCAAG GCGATACTGA CACAGGGTTT GTGTTTTTCC AACATGAGTT 4381 TTGAGTTCTT ACACGCTGTT TGCTCTTTTT GTGTGTTTTT TCCCTGTTAG GTGTTTTTGG 4441 TGGTATAGGC GATCCTGTTA CCTGCCTTAA GAGTGGAGCC ATATGTCATC CAGTCTTTTG 4501 CCCTAGAAGG TATAAACAAA TTGGCACCTG TGGTCTCCCT GGAACAAAAT GCTGCAAAAA 4561 GCCATGAGGA GGCCAAGAAG CTGCTGTGGC TGATGCGGAT TCAGAAAGGG CTCCCTCATC 4621 AGAGACGTGC GACATGTAAA CCAAATTAAA CTATGGTGTC CAAAGATACG CAATCTTTAT 4681 CCTAGTAATT GTGGTCATTG GGTGATGTTG GTTTGGGCAG GCCATCTCTA ATATCCTTGA 4741 AACACCTTTT TCTGCTCTCC AGGAAGGGGT CAGGGCTGCC ACAGCGGGGC TTGGAGTGC

(2) INFORMATION FOR SEQ ID NO:2477: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3661 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2477:

1 GAATTCCCTG TAAGCCCTGT TACAGGGGCT GCACCCCAGA TACAACCTGA CCTGTGTCCA

61 AGGCGGGCAA CTCAACCCTT AGATATTGAA TGGGTCCCAT GGCACCAATG CTTAAACACC

121 AGCAGCCCTC ACAACCACAG ATCGTGTTTT AAGGATGAGG AGGTAGTTCT CTGGATGCAC

181 AGGCTTCAAT CCAAATGGGC TCATGACGCC GCAGCACACA CCCAGTCTGC AGCCTGAAGA

241 GTTGGAGCAT TGCATTCACA GAAAGCATCC AGACATGATC ATGGGCTCAG GGATACACCT

301 GTTCTCCGAT GTGTACCAGT GAAGGATGGA AACTCCTATG CCTCCCAGAA AGCACCACTC

361 AAGCTTTTGC TGAATGCTTC TCTGAAGGCC CACAAGGCTG AGAGGCTGTG CAACACCAGC

421 AGTAAAGTGA ATGCCCAGAC TCCCACCTCC TTTCTTGGGT GGCCATCTGG AAAGGCCACT

481 CCCACCCTGA TGGCTAATGC CTCAGACCAG TTCTTGGCCC AGATGATCCT AGACAATTGT

541 TTAAGCTTAA ACTGTTCATT GGCCAAGCAA ACAGGTGATA GTACCTCTGG GGAACCACAT

601 GCCGCGTGTA CATCCAGATC TCAGGAGAAC CCAAAAATGT CTGTTCCACA TAGCAACAGA

661 AGCCCAGGTA GCACTCAGTC TCACCTGGGT GTTCTCCAAC ATCCCAGCTC AGCCAAATGG

721 CTTTCATTAG TTTTTATGGT TAGACCCCAG GTCCTCGGGA CACTGCTTTA GAAACACATT

781 CCAAATCCTC CTCTGTGTGC AGGTGGCATT CCTATCCCAA TCTCTTTGCA GGGCGTATAC

841 TGTGATACGC AGCCAGGCTG TCCCAGAGGC CTTAAATATT CCCTTGGTGC AGGTAGTTCA

901 GCTTAGCCAC AGCCAATGCA TCACAGGGTC AACTGTGTTA GGAGCCATTG AGAATCCATA

961 GTTGGTTGCT GCCTGGGCCT GGCCAGGGCT GACCAAGGTA GATGAGAGGT TCCTCTGTGG

1021 AGTTCTACTT TAACCTCACC TTCCCACCAA ATTTCTCAAC TGTCCTTGCC ACCACAATTA

1081 TTTAATGGAC CCAACAGAAA GTAACCCCGG AAATTAGGAC ACCTCATCCC AAAAGACCTT

1141 TAAATAGGGG AAGTCCACTT GTGCACGGCT GCTCCTTGCT ATAGAAGACC TGGGACAGAG

1201 GACTGCTGTC TGCCCTCTCT GGTCACCCTG CCTAGCTAGA GGATCTGTAA GTACTACAAA

1261 ACTTAAACTT TACACTGAGT TTTCATCATT GAAGCTATGC CTCCAATCTG ACCTCTGACT

1321 GTGGGGCCGC CCCAGAGGGA CCCAGCGGGT GAATCCCTGC TAGGAACGTC TGTCCGGACC

1381 TCTGGTGACT GCTGGGGACG ATGGCTTCCA GCTAACTTAA TAGAGAAACT CAAGCAGTTT

1441 CCTTCTAAAT ACACATGTCA CATGTCCTGG TTGACATGTC CAGTAAGAAG ACTATCACAG

1501 GTCTTTGGAA CATTCTTTTG AGAGAAACCT ATTTAGGTCC TTGGTCTGTT TTTCAATCAG

1561 GTTGTTTGAT TTTTGCTATT GAGTTGTTGG AATTCCTTAT GTATTCAGAT ATTTGCCCCT

1621 TCTGCCATGT AGGTTTTGCA AATATTTTCT CTCATTTTCT GGGTTATCTT TTCACTCGGT

1681 TGATTGTTTC CTTTGCTGTG CAGATGCTTT AGCGTTAAAT GAAGCCACAC TTGTCTATTT

1741 TCCCTTTTAT TGCCTGTGCC TTTGGTGTCA TAGCCAAGAA ATCATTACCT ACATCAATGT

1801 CAAAAGCTTT ATCCTTCTAT ACACTTCTAG TAGTTTATGG TTTCAGTTGT TACATTTAGG

1861 TTTTCAATTC ATTCTGAGTT GATGTTCCTA CATGGTGTGA GATAAAGATT TAAATACATA

1921 CATATATAAA ATCATGAGGT AGTGTACACT ATAAATATAC AATTGTTAAT TGTTACTCAA

1981 GTCTAAGTAG AGGTGGAAAT AATAAACTTT CTTTTTTTTA CTTAAACCAC TCTGTGTCAC

2041 TGAGCTGATT TCACCTTTAG CCTGATAAAA TCATTGTCCT CTCCACCCTG ATTCCTACAG

2101 GAGACTACTC ACCCCATAAC CTCAAAAACC TCTTCATGAG GATGGTAAGT CACCTGAATC

2161 CTGAAGTGAA TTACTCGCTA TTCCATTGGA ACTCATATAG GACACCAGAA TCTAGACCTC

2221^' CAGAGAACAG CAGGACCCAT CTTCAGAAAA TAAGAAGCAT TTGTTCCCTG AGCCTGTTGA

2281 ATCAAAGTGC AATTTCTATT CTTTTTGGAA TGTTAAAAAG TGAATCATAA TATTTAAGCA

2341 GGTGAACCCA CGAGTAACAT AGCAGGGTCT TTCTTGTCAT TATTAGCTCC AACCTAGCAC

2401 AGACATTAAA GGTACAGATG TATACTAGCA TGAAACTGGG AGAACAGGAG CATTCGAGCA

2461 ACCTTGAGAC CAATGGGCCT CTCTTATAAA ATGCACACCT CCTCTCACTG AGATTGAGGA

2521 AGGTTTCTTG TCTCCGAGCC TTCTCCCAGT AGAGCTATAA ATCCAGGCTG GCTCCTCCCT

2581 CCCCACACAG CTGCTCCTGC TCTCCCTCCT CCAGGTGACC CCAGCCATGA GGACCCTCGC

2641 CATCCTTGCT GCCATTCTCC TGGTGGCCCT GCAGGCCCAG GCTGAGCCAC TCCAGGCAAG

2701 AGCTGATGAG GTTGCTGCAG CCCCGGAGCA GATTGCAGCG GACATCCCAG AAGTGGTTGT EPI-109 612

2761 TTCCCTTGCA TGGGACGAAA GCTTGGCTCC AAAGCATCCA GGTGAGAGAG GCAGGCATGC

2821 AGAGCTGCTA AGTCTAGAGG GAAGGACGGG AGAGAGGTTC CAGAGTTGGG TCTCAGCAGT

2881 CTATGTCACT GAGGTGGCTT CACTTAGAAT CTCTGGGCAT TGATTTTCTC ATCTAGAAAT

2941 TGAACAGAGA GCCAAATAAA CCTGAGAAAC TTTATTTCTC CAAAGACTTG ATTCCAAGAA

3001 ACATCTGTGA AATTCACTAA GTTTAAGATA TGAAGAGACA GACTAGTTAT TTCTGGATCT

3061 AAACAAGTAG ACTTAGTTGT AAAGAGAACA TTTTACTCTA TCTACAGAAG AGCTTTTAAA

3121 AACTGCAGCC AAGCCTGAGG GTAAGTTCAG GTGTGTGTGT GATGGGGCAG GAATGCAAAA

3181 ATGAGAGCAA AGGAGAATGA GTCTCAAATT CTGTGTGACA AGCACTGCTC TGCGTGTTTA

3241 TTCCTATCGA CTGAGGTTGT TCGTGCTACC GGCTGCAATG CAGCCAGCAT CACCTGTCAG

3301 CTAGCATGTG ACTTCCCCGA GATTCTTTTT CTTACCCACT GCTAACTCCA TACTCAATTT

3361 CTCATGCTCT CCCTGTCCCA GGCTCAAGGA AAAACATGGA CTGCTATTGC AGAATACCAG

3421 CGTGCATTGC AGGAGAACGT CGCTATGGAA CCTGCATCTA CCAGGGAAGA CTCTGGGCAT

3481 TCTGCTGCTG AGCTTGCAGA AAAAGAAAAA TGAGCTCAAA ATTTGCTTTG AGAGCTACAG

3541 GGAATTGCTA TTACTCCTGT ACCTTCTGCT CAATTTCCTT TCCTCATCTC AAATAAATGC

3601 CTTGTTACAA GATTTCTGTG TTTCCACCTC TTTAATGTGT GATATGTGTC TGTGTCAAGA

3661 CACTTGGGAT ACACGTACCA AAACGCAAAA TCAAATTTTT GAACAATATA

(2) INFORMATION FOR SEQ ID NO: 2478: (i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 421 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2478:

1 CCTACCTTGC TATAGAAGAC CTGGGACAGA GGACTGCTGT CTGCCCTCTC TGGTCACCCT

61 GCCTAGCTAG AGGATCTGTG ACCCCAGCCA TGAGGACCCT CGCCATCCTT GCTGCCATTC

121 TCCTGGTGGC CCTGCAGGCC CAGGCTGAGC CACTCCAGGC AAGAGCTGAT GAGGTTGCTG

181 CAGCCCCGGA GCAGATTGCA GCGGACATCC CAGAAGTGGT TGTTTCCCTT GCATGGGACG

241 AAAGCTTGGC TCCAAAGCAT CCAGGCTCAA GGAAAAACAT GGACTGCTAT TGCAGAATAC

301 CAGCGTGCAT TGCAGGAGAA CGTCGCTATG GAACCTGCAT CTACCAGGGA AGACTCTGGG

361 CATTCTGCTG CTGAGCTTGC AGAAAAAGAA AAATGAGCTC AAAATTTGCT TTGAGAGCTA

421 CAGGGAATTG CTATTACTCC TGTACCTTCT GCTCAATTTC CTTT

(2) INFORMATION FOR SEQ ID NO:2479: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3781 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2479:

1 CCTGAGACAG AGGCAGCAGT GATACCCACC TGAGAGATCC TGTGTTTGAA CAACTGCTTC

61 CCAAAACGGA AAGTATTTCA AGCCTAAACC TTTGGGTGAA AAGAACTCTT GAAGTCATGA

121 TTGCTTCACA GTTTCTCTCA GCTCTCACTT TGGTGCTTCT CATTAAAGAG AGTGGAGCCT

181 GGTCTTACAA CACCTCCACG GAAGCTATGA CTTATGATGA GGCCAGTGCT TATTGTCAGC

241 AAAGGTACAC ACACCTGGTT GCAATTCAAA ACAAAGAAGA GATTGAGTAC CTAAACTCCA

301 TATTGAGCTA TTCACCAAGT TATTACTGGA TTGGAATCAG AAAAGTCAAC AATGTGTGGG

361 TCTGGGTAGG AACCCAGAAA CCTCTGACAG AAGAAGCCAA GAACTGGGCT CCAGGTGAAC

421 CCAACAATAG GCAAAAAGAT GAGGACTGCG TGGAGATCTA CATCAAGAGA GAAAAAGATG

481 TGGGCATGTG GAATGATGAG AGGTGCAGCA AGAAGAAGCT TGCCCTATGC TACACAGCTG

541 CCTGTACCAA TACATCCTGC AGTGGCCACG GTGAATGTGT AGAGACCATC AATAATTACA

601 CTTGCAAGTG TGACCCTGGC TTCAGTGGAC TCAAGTGTGA GCAAATTGTG AACTGTACAG

661 CCCTGGAATC CCCTGAGCAT GGAAGCCTGG TTTGCAGTCA CCCACTGGGA AACTTCAGCT

721 ACAATTCTTC CTGCTCTATC AGCTGTGATA GGGGTTACCT GCCAAGCAGC ATGGAGACCA

781 TGCAGTGTAT GTCCTCTGGA GAATGGAGTG CTCCTATTCC AGCCTGCAAT GTGGTTGAGT

841 GTGATGCTGT GACAAATCCA GCCAATGGGT TCGTGGAATG TTTCCAAAAC CCTGGAAGCT

901 TCCCATGGAA CACAACCTGT ACATTTGACT GTGAAGAAGG ATTTGAACTA ATGGGAGCCC

961 AGAGCCTTCA GTGTACCTCA TCTGGGAATT GGGACAACGA GAAGCCAACG TGTAAAGCTG

1021 TGACATGCAG GGCCGTCCGC CAGCCTCAGA ATGGCTCTGT GAGGTGCAGC CATTCCCCTG

1081 CTGGAGAGTT CACCTTCAAA TCATCCTGCA ACTTCACCTG TGAGGAAGGC TTCATGTTGC

1141 AGGGACCAGC CCAGGTTGAA TGCACCACTC AAGGGCAGTG GACACAGCAA ATCCCAGTTT

1201 GTGAAGCTTT CCAGTGCACA GCCTTGTCCA ACCCCGAGCG AGGCTACATG AATTGTCTTC

1261 CTAGTGCTTC TGGCAGTTTC CGTTATGGGT CCAGCTGTGA GTTCTCCTGT GAGCAGGGTT

1321 TTGTGTTGAA GGGATCCAAA AGGCTCCAAT GTGGCCCCAC AGGGGAGTGG GACAACGAGA

1381 AGCCCACATG TGAAGCTGTG AGATGCGATG CTGTCCACCA GCCCCCGAAG GGTTTGGTGA

1441 GGTGTGCTCA TTCCCCTATT GGAGAATTCA CCTACAAGTC CTCTTGTGCC TTCAGCTGTG

1501 AGGAGGGATT TGAATTATAT GGATCAACTC AACTTGAGTG CACATCTCAG GGACAATGGA

1561 CAGAAGAGGT TCCTTCCTGC CAAGTGGTAA AATGTTCAAG CCTGGCAGTT CCGGGAAAGA

1621 TCAACATGAG CTGCAGTGGG GAGCCCGTGT TTGGCACTGT GTGCAAGTTC GCCTGTCCTG

1681 AAGGATGGAC GCTCAATGGC TCTGCAGCTC GGACATGTGG AGCCACAGGA CACTGGTCTG EPI-109 613

1741 GCCTGCTACC TACCTGTGAA GCTCCCACTG AGTCCAACAT TCCCTTGGTA GCTGGACTTT 1801 CTGCTGCTGG ACTCTCCCTC CTGACATTAG CACCATTTCT CCTCTGGCTT CGGAAATGCT 1861 TACGGAAAGC AAAGAAATTT GTTCCTGCCA GCAGCTGCCA AAGCCTTGAA TCAGACGGAA 1921 GCTACCAAAA GCCTTCTTAC ATCCTTTAAG TTCAAAAGAA TCAGAAACAG GTGCATCTGG 1981 GGAACTAGAG GGATACACTG AAGTTAACAG AGACAGATAA CTCTCCTCGG GTCTCTGGCC 2041 CTTCTTGCCT ACTATGCCAG ATGCCTTTAT GGCTGAAACC GCAACACCCA TCACCACTTC 2101 AATAGATCAA AGTCCAGCAG GCAAGGACGG CCTTCAACTG AAAAGACTCA GTGTTCCCTT 2161 TCCTACTCTC AGGATCAAGA AAGTGTTGGC TAATGAAGGG AAAGGATATT TTCTTCCAAG 2221 CAAAGGTGAA GAGACCAAGA CTCTGAAATC TCAGAATTCC TTTTCTAACT CTCCCTTGCT 2281 CGCTGTAAAA TCTTGGCACA GAAACACAAT ATTTTGTGGC TTTCTTTCTT TTGCCCTTCA 2341 CAGTGTTTCG ACAGCTGATT ACACAGTTGC TGTCATAAGA ATGAATAATA ATTATCCAGA 2401 GTTTAGAGGA AAAAAATGAC TAAAAATATT ATAACTTAAA AAAATGACAG ATGTTGAATG 2461 CCCACAGGCA AATGCATGGA GGGTTGTTAA TGGTGCAAAT CCTACTGAAT GCTCTGTGCG 2521 AGGGTTACTA TGCACAATTT AATCACTTTC ATCCCTATGG GATTCAGTGC TTCTTAAAGA 2581 GTTCTTAAGG ATTGTGATAT TTTTACTTGC ATTGAATATA TTATAATCTT CCATACTTCT 2641 TCATTCAATA CAAGTGTGGT AGGGACTTAA AAAACTTGTA AATGCTGTCA ACTATGATAT 2701 GGTAAAAGTT ACTTATTCTA GATTACCCCC TCATTGTTTA TTAACAAATT ATGTTACATC 2761 TGTTTTAAAT TTATTTCAAA AAGGGAAACT ATTGTCCCCT AGCAAGGCAT GATGTTAACC 2821 AGAATAAAGT TCTGAGTGTT TTTACTACAG TTGTTTTTTG AAAACATGGT AGAATTGGAG 2881 AGTAAAAACT GAATGGAAGG TTTGTATATT GTCAGATATT TTTTCAGAAA TATGTGGTTT 2941 CCACGATGAA AAACTTCCAT GAGGCCAAAC GTTTTGAACT AATAAAAGCA TAAATGCAAA 3001 CACACAAAGG TATAATTTTA TGAATGTCTT TGTTGGAAAA GAATACAGAA AGATGGATGT 3061 GCTTTGCATT CCTACAAAGA TGTTTGTCAG ATGTGATATG TAAACATAAT TCTTGTATAT 3121 TATGGAAGAT TTTAAATTCA CAATAGAAAC TCACCATGTA AAAGAGTCAT CTGGTAGATT 3181 TTTAACGAAT GAAGATGTCT AATAGTTATT CCCTATTTGT TTTCTTCTGT ATGTTAGGGT 3241 GCTCTGGAAG AGAGGAATGC CTGTGTGAGC AAGCATTTAT GTTTATTTAT AAGCAGATTT 3301 AACAATTCCA AAGGAATCTC CAGTTTTCAG TTGATCACTG GCAATGAAAA ATTCTCAGTC 3361 AGTAATTGCC AAAGCTGCTC TAGCCTTGAG GAGTGTGAGA ATCAAAACTC TCCTACACTT 3421 CCATTAACTT AGCATGTGTT GAAAAAAAAA GTTTCAGAGA AGTTCTGGCT GAACACTGGC 3481 AACGACAAAG CCAACAGTCA AAACAGAGAT GTGATAAGGA TCAGAACAGC AGAGGTTCTT 3541 TTAAAGGGGC AGAAAAACTC TGGGAAATAA GAGAGAACAA CTACTGTGAT CAGGCTATGT 3601 ATGGAATACA GTGTTATTTT CTTTGAAATT GTTTAAGTGT TGTAAATATT TATGTAAACT 3661 GCATTAGAAA TTAGCTGTGT GAAATACCAG TGTGGTTTGT GTTTGAGTTT TATTGAGAAT 3721 TTTAAATTAT AACTTAAAAT ATTTTATAAT TTTTAAAGTA TATATTTATT TAAGCTTATG 3781 TCAGACCTAT TTGACATAAC ACTATAAAGG TTGACAATAA ATGTGCTTAT GTTT

(2) INFORMATION FOR SEQ ID NO-.2480: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 141541 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2480: GATCAAAATT TTTACCTATT ATGCATTTGA TATATAAATA AGTATATAAA TGCACACACA

61 GACACAGCAA TGATGGTGAA CAGTCTTCAT ACAATTATAT GGATGAATCT CATAAAATGC

121 TGAGTTAAAG AAATCAGACC AAAGAACATA TACTGAAAGA TTCTCTCTAT ATACAAAGTT

181 CAAAAATAGG TGGACCAATT CATGGTGGTG TTAGAAATCA GAAGAGAGGC TACCTTTGTG

241 GGGAGGGGAC AGTTTAATGC CCAGAAGCGG TAAATAAGGA ATCCTCTGGG GAGTGGTAAT

301 GATCTGGATG CTGGCTACAG GATGTGTTGG TTGTAAAAAT GCATTTTTTT ATATCTAGCT

361 TTTTCCATGT GTATATTATA CTTCAAAGAA GTTCAGTTAA TAATTTCTCA TGTCACTGTA

421 GAGTAGCTCA GTTAGCCCCA GCAAGCCTCT GGCTTAATCT TGTTTTACCT TAAGCCATCA

481 GTCATTTACA AGTAGGAAAA TTCACAGGGA AAGTTAGAGT ATAAAATCCA GAATGAAGGT

541 TTACTGGGTA AGAGTCTCTC CATTTTCCAA AGCCCGTTTA TTTCTTGATT CCAGTTCTTA

601 AGAAGTCTCA GCATTGTGTC TTTTTCATGT ATCTTACAAG AAGACAGCAT GTGCTTCTAA

661 CACCTGATAC ATTGTATCTA CCAGCACTTG GTAAACAGAA AAGAACCACA TTTTTCTTGT

721 AGGAGAAATT TGGTGCCTAT TTCCTACCAG GCACCAATAA GTGGGACCAA TAGGTGGGAT

781 TAAAGATACA GTAGAAAGTA TTTAAAACTT GCCAGGGGGC AATAGTCTGA AAATAAGTAA

841 ATTGGTGCTA TAGAATGGAA GTTACAGGCT TCTTTCTTTT TTCCCACAAG ATCTGCTCCT

901 TGAGCCCCTA GAGACTTTTC TGTCTGTTAC TGTTTCTTCA TTCCTCATCT GCAGAGCCAG

961 CCCTGAGAAG TGCAGACCAA AGCCAGGGAA GGCTCTGCAA AGATGTACAA ATGGAAGTCA

1021 CCTTAATAAC CTCTGACTGC TGCGCATAAT ACATTTCACT CAAAAGAGGG GTTAAACAAT

1081 GGAACAGAAT ACAGAGGCCA GAAATAATGC TGAACACTGA CAACCATCTG ATCTTTGACA

1141 AAATCCACAA AAACAAGCAA TGGAGAAAGG ACTCCCTATT CCATAATGGT GCTGGGATAA

1201 CTGTCTAGCT ATATACAGAA GATTGAACCT GGGCCCCTTC CTTACATCAT ATACAAAAAA

1261 TAACTCAAGA TGGAGTAAAG ACTTAAATCT AAAACCAAAC ACTATAAAAA CCCTGGAAGA

1321 TAGCCTGGGA AATACCATTC TGGACATAGG ACCTGGCAAA GACTTCATGA CAAGACACCA

1381 AAAGCAATAG CAACAAAAAC CAAATTGACT AATGAAACTA ATGAAACTCT TTAGTTGTAC

1441 AACAGATAGT TTATCTGTAC AACAAAATAA ACTATCAACA GAGTAAACAA CCTACAGAAT

1501 GGAAAAATTT TTTGCAAACT ATGCATCTGA CAAAGGTCTA ATATCCAGAA TCTATAAGGA

1561 ATTTAAACAA ATTTACAAGC AAAAAAATGA CCTCATTAAA AAGTGGGCAA AGGACATGAA

1621 CAGATGCTTT TCAAAATAAG ACATTCACAC ATCCAACAAC CATATGAAAA GATGTTTAAC EPI-109 614

1681 ATCACTAATC ATTAGAGGAA TACAAATCAA AAGCATAATA AGATACCATC TAATACCAGT 1741 AGGAATGACT ACTATTAAAA AGTCAGACAA TAACAGATGC TGGTGAAGGT TGTGGAGAAA 1801 AGGGAATGTT TATGCACTGC TAGTGGGAAT GTAAACTAGT TCAGCCATTG TGGAAGAGAG 1861 TGTGGTGATT CCTCAAAGAA TGTAAAACCG AACTGCCTTT CAATCCAGCA ATCCCATTAT 1921 TGGATATACA CCAAAAGGAA TAGAAATTGT TTTACCGTAA AGGCGCATGC ATGCATATGT 1981 TCATTACAGC ACTATTTACG ATAGCAAAGA CATGGAATCG TCTAAATGCC CATCAGTGGT 2041 AGACTAGCTA AAAAAAAAAA AATGTGGTAC ATATACATCA CAGAATAGTA TGCAGCCATA 2101 AAAATGAACA AGATCATCAT GTCCTTTGCA GCAACATGGA TGTAGTTGGA GGCCATTATC 2161 CTAAGCAAAT TAATGCAGGA ACAGAAAGCC AAATACCACA TGTTCTCATT TATAAGTGAC 2221 AGCTAAATAT TGAGTACACA TGGACACAAA GAAGGGAACA ATAGACATGG GACCTACTTG 2281 AGAATAGAGG GTGGGAGGAG GGTGAGGATC AAAAAGTACC CATAGGACAC TGTGCTTATT 2341 ACCTGGGTGA TGAAATAATT TGCACACCAA ACCCCTGTGA CACACAATTT ACCTATATAG 2401 AAAACCTGTG CATGTACCCC TGAACCTAAA AGTTAATGGT GGGGGGGTGG GGTTAAGCTA 2461 CTTTGTGGTA TAAATCTGAG CATTCATATT AAAATAAAAT ATTTACCTCA TTAGAGTAAT 2521 TAACATTTAT TAAGCAAAGA GCCAAGTACC TTACACACAT GATGTTTAAT CTCACAATGA 2581 TCTTTAATCT CATAACAACC GTCCATTGTA TGTACATATG TGGAAATTGA GCCTTGGAGA 2641 GATTAAATGC ATGGGGCATG CCATTTGACT AGAAACTGGA AGCATCAGGA TTTAAACTCA 2701 GTTCTGAATG GTTTTGTAGG CTTTGTTTTT TCCACATTAT AGCATGGCCT GCCATGAAGA 2761 ACAGGTCCTT TCTGGTGTTT GTCTTGTTTG GTTTAAGTGA AGCAAATATT TATTTAAATA 2821 TTCAAGATAT GCTGTTAAAT TTTTACTCAA AAATTTGAGT ACAGTATGGA TCTTCTGAAG 2881 CCAAATAACT CTTATTCAAT GCTTAGTTGA GAAATTTTAT GGAGTAGTTC TCAATTTTTA 2941 TGTAGTTCCA CTGCAAAGGT AAGTCTTATG GAAAGATTCA CTGTAATTTT TTTTCCTCAT 3001 TTGGACATCA GCTTTTTCTT TTCCTCAGAC CCGCTGAAAG ATAATTTTTA AAATAAAAAC 3061 CTTGTTTTTA TATCAAGTGG GGACATTTTT TCCAAATGAA AACCGTGTAT TCATTTTATA 3121 TGATAAAATC AATGTTATTA TTTTTAAAAT TTTGATTTAA AAATCATTAA AAATAAATTT 3181 TCAGATATTA CCTGAAATTC TACCATCCAG AGATAATAGT GCTTAAAGAT TTGATATATA 32 1 GACACACACA CATATATACA TATATATCAT CCTAAACTTC TTTGTATAAA TGTATATAAA 3301 GTTTTTAATA AAAACTAGGA GATTAATGCC CTTTGAATGA AAATAAATAC AATGTGTATG 3361 CTTTAACATC TTGCCTTTAC TTTATAACAT TTATCACAGC AGTCATGAGA TAATGATTTA 3421 CATGGTCATT GTTAGTAAGC TAATAGCTAA GTGCATGAAC TCTGGAGCTA GCCTCCCTGG 3481 ATTTTAATCC CAGATCTGTC ACTGACCAGC TGAGCAATAC TAGGTAAATT GCTCTTGTTC 3541 CTTAGTTTCT TCATCTGTAA AATAGAGATA AAAATAATAT CCACCTCATA GGATTGGTGT 3601 GAGCATTAAA TGAGCATACG TATGTAGGCC ACTTAACAAC AATGCCTTCA CATACTGAAC 3661 ACAAATATAC GAGCTGTTGT CTTATTGGGC TCATGTTTTT CCTACCACTA AGCCGCATGC 3721 ATGCAAGGAC CATGTTGGTT TTGTTCCACA TTGCATCCCC AACCTGGTAT ACAGTGTGCA 3781 TTCAATAGTT GTTGACTATT ATTACTAGTG GCATTTAACA AATATCTGTT AAATGAGTGA 3841 AGAAATACCC ATTTACTGCA AGTGTGTCTA ATATTGATGG CATAATGGGG GAAACTCAAA 3901 CTCTGGAGTC AAACAGGTTT TAAAACCTTA TTCCCTCATC CTCAGTTATT GACGTTTTTT 3961 TTTTGGCAGG TGTGTGTGTG GGACAACTTA TTGAACTTTT CTGAATTTCC AGCTTCGCAT 4021 ATATAAAATA GAGATAGTGA TTCATTCTTG CAATGTATGG ATTTGAGACA ATTGTGTAAG 4081 TTTATCAATA AATAGTAGCT ATTTTTGTAT AAGTATTACA TATAATATCC AGGCCACTGC 4141 TTTGCATAAC CCAAAAGGGG CACCATTCAT GCAGAATACA ACATAAATGG TGTCCCTGGA 4201 GCAGTGCAGT ATAGGAACCC TGAGGGGACC TACAGTATAC TTTATAGTTC ATAGATTACA 4261 AATTATCCCT TTATCAGAGT CTCTCAAGGT TGGATGTATT TGAGGTCCAT AAGAGCAATT 4321 TAGGATTAAC AGTAGCTGCA GAAACCATCT GCAGTGATAT TCTCATTTTA AATCCGCGGG 4381 AAAGAAGACA GCTATAAACT TGGGACCTGG GTTTAAGCAT TTTAAATGCC AAGTTCACCA 4441 TTTTCTAAAA CACAACAAAT ACCCAGTGAG AGAGGGAGAA GGGAAGTAAA TGCCTCTGAA 4501 TAAGCAAGTT AATGTCAGTA GTTGTACTGT ATGCATATTG ATGAACAATA GAGGAACCAA 4561 TGTCCAATCA GATGAGCAGG ATATTTGGCA ATAACAAGTT GCCTTTGAGG AAAAATGATT 4621 TTCTTGGCAA GTTCTTTATC AGCATTACAA AGCTAAAAGC TACGCTTATC ATCACTTATA 4681 CTAGCATACC CTGTTGTGCA AATGCTGTCT GTGTTTGCAT CTGCTATTGT TGATGCCTGG 4741 TGCATGAATC AGGACTCCAG CCCACAAGTT TTCCCAGAAC TTTCTTATGG CCATCATCTT 4801 TAAGTGTCTG GTGAACAGTC ATAGTTTGGT ACACAAAAGG GTCAACCTGG GGGATGGCTA 4861 GGGTTTGACT CAGTCGTTAC ATTTCAATAG AGCAGGAAGG GGAAATGGTG GCCTGTAACC 4921 TCAGGGAATT TTGCCAGTTG GTCCACCCCA CTCTCTCTCT CCTGCTCTGA GGAAGTGGCA

4981 CAGCCTAGAA CAGCACCACA GGTGAGAGAA ATGCAAACCC TAACCAGAGA AGCAGACTCT 5041 TTGCCAGTAG TAATAGTTCA GGACCACCAC CAGCTTTTAT TAAAATTTTT AATAACACTC 5101 AAGTATTGGC AGAAAGAAAT AATCTTGGGT TAACTATAAC TAGAATATTG ACTCTTCCTC 5161 TGTGGAAGAA TCAGCCAATC ACATTTGTTT ACATCAGTTC CCCTGAAGAA GAAAAATACA 5221 CTGATGTTGC AGCAAGACAA ATTTAAGCTA GATGTAAATA ACTTCCTTTA GCCTGTAATG 5281 CTAGGCTAAT TACATATTGG AACTATTTTT TCAGGGAAGA ATTGTGTAGG GTTTCAGGGA 5341 AGAATTCTGA AGAAAATATA GAGCTGAAAT GATCTTGCAG CTCACTGAAA CTGCAGGGTT 5401 TAGATCCACA CTGATACTCG TTCTATTATC ACTGTAATGA AGGCTGATGG AATAAGTAAA 5461 AATGTTTTGT ATTAGTATGT TTTTACACTT ATTTGCAAGG CATAAATAGG TTAGGTTTTG 5521 ATCTTAATTT AATTCTAACA TGTATTGTGC ACAAGCTGTG AGCAGTTTTC AGGAGTTAGG 5581 TATCTGGCCA TGACTGATTT TTCAGGAGTT AATCATCTGG TAGAAGGGTC ATACACAATA

5641 GGAAGATGTG TGTGACAGGT TGTGATCATT ACTATAATCA CACAGAGAGC TGTAGAATTT 5701 TAGGCTGGCA GGGTGGCTCA CGCCTGTAAT CCCAGCACTT TGGGAGGCCA AGGCAGGCGG 5761 ATCAAGAGGT CAGGAGATGG AGACCATCCT GGCTAACACG GTGAAACCCC GTCTGTACTA 5821 AAAATACAAA AAAAAAAAAA AGCCAGGCGT GGTGGTGGGC GCCTGTAGTC CCAGCTACTT 5881 GGGAGGCTGA GGCAGGAGAA TGGCGTGAAC CCGGGAGGTG GAGCTTGCAG TGAGCCGAGA 5941 TCGCATCACT GCAATCCAAC CTGGGCGACA GAGGGAGACT CAGTCTCAAA AAAAAAAAAA 6001 AAAAAAAGTC ATGTTAGATC CAGAGGGGTA GCAACTGGGG CTGGGCTGTC AGTCAACTCA 6061 GTCAACTCAG TCAACTCTGC TCCCCCACAG GAGATGCCAG TGATGCATTT TCATGGCCAA 6121 CATTGTCAGT CAGCATCATT GAATTACTCC TGATTATAGA GACACAGCTG CAAACGATTC EPI-109 615

6181 CCCATTAAAT ATGATGTTTC TTGCAATGTT TGGAAGGTAC TCCTTTTTAG TAAGGGAAAT 6241 CCCCTCTTCT GGCTTGCTGA AAGTTTTTTC TTTCCATTTT AAAAATCGTG AATTCCTTTT 6301 TGCAATATTG AGGTGGTTAT ATGGTTTCTC TTCTCTAATC TGTTAATATG GTGATTTAAT 6361 GGTTAGAAAT TTTCTAATGT AAATTCCACT CATATTGCAG AAATAAACCT AAACTGAGCA 6421 TGAGGCTATA TTTTTTATTT GCTTCTATAT TTGGTTGCTA TACAGTATTA TGTTTAAGAT 6481 TTGTTCACAT ATATTTGTGA ATGGGATTGG ACTATTTTTC CTTCTTGCCG ATTTTTATCT 6541 GGTTTTTAAA TTAAGGATAT TTTAGACTTA TGAAATATTT GGCAAACAAT CCTTGGCAAG 6601 TAATTTTTTG GGGAATTTGT TTTGGCTATT TTGAGTATTA CCCAATATAT TTTAATTAAG 6661 TTATTCTTAA TGTTTTCTTA ATTAAAAAAA TTACCTACTC TAGAGATATT CTTTATGTAC 6721 TCCAGATTTT GTCTATTTAT ACCACTTTTC TTTTTTCCTC GATGAGTGTC ATAGATGTTC 6781 ATCTATTTTT TTATCTTCTT TGATCTTCTC TTATTCCTTG TTTCTATTAA CTTCTGAAGT 6841 TTATTATTTT CTTTTTTCCA CTTCCTTATG GTTTATTCTT TCAATTTTTC TCTAACTTCT 6901 TAAGTTGGGT GTTTAATTTT TAGCTTGCTT TGCTTTTTTA GGATAAGCAT TAAAACTACA 6961 AATTTTCCTT GTTATTCTTT TGCTGCACCC CAAATTGTTG ATATTTCTAT TGTCTAATTT 7021 CTATTCAATT AGAATACTTT AAAGTTTCTT TTTGGTTTTT AAAAACTAAC TTTTTAAATT 7081 GACAAATAAA AATTGTGTAT ATTTATTGTG CACAGCATAT GGCTTTGAAA TATATGTACA 7141 TTGTGGAATG GCTAAATTTA GCTTATTAAT GTATGCATTA TCTCACATAC TTATCATTTT 7201 TTGTGGTGAG AGCTATGTGA CTTTTGAACT TATGAGTTAT TTAAATATTT TTAAATTATT 7261 AAGCATATTG GGATTTTAAG TAATTTACCT TTTTATTATT AACTTATAAC AAGTAGAACA 7321 GTTAACCTGT ATGATTCTAC ATCATTGAAA TTTATTGACA TTTGCTTCAT AGTCTATTAT 7381 ATGGTCTACT TTTGTTCATG TTACATCTGT AGTAGAATTG GCTAATAGTT GAGTAAAGTA 7441 CACATATGTC TATGAAATCA AGTGTAATCC AGAGAAAAAG AGAAATTTAC TGAATATATT 7501 GTTCTAGGTG CTATTATATG TTGTCATGTT TAATCCTCAC CACAATTGTA TGAGGCAGCC 7561 ATAATTAATT CCACTTTACA CATGAGGAGC CTGAGGGTTA AAAAAAAAGC TAGCTCTACT 7621 ATTTGTAAAG AATGAAGCAA AGATACAAAT GAAGGCCCAC ATATCCTATA ACTAGATATT 7681 TAAGCATTTT AATTCAAGCT TTAAAACTGC TAAATAAAAT GTGCTCCAAT TTCTATATTG 7741 ACAGACATAC CTTCCTAATG AGCTGGGGTT CGAATTTAGA AATCTTTGAT GCTTCAGAGT 7801 CCACACTGAA ATGTGGAGGC ACATAGTGAG TTGGTCCCCA GCCTTCAGTC CACCCACCTT 7861 CTCTTTACTA AATCACCTTT CACATACATG TATGAACACC CCAGCCTCCA AGTCCAAACC 7921 CTAAACAAAA TGGGACACCC TTGTGCATAC ACAGAGACAC AGCCCATCCT CAGGAAAACC

7981 TGGAAAAGTC CATACAAGTT CTGGAAGCAA GCTTGGGACG GTTTCAGTAG TGTGGTCTAT 8041 AAGGGAGGCC TCAGAAGACA GGTTTTCTTA ATTCTGTGAA CTTCTCCCAC AGTAGAAAGG 8101 GTGCTGGAGG AGGGTCAGAG TGAGGACTTC TAAAGCATGG GTCCTGAGTA GGGGCCACTC 8161 TTGCCCAAGT CTAAGAAGGG TACTAGAATA GCACACTACT ACTAGATACT AGAACCCAGA 8221 TACAAGCACA GGTCTTCTGA AATTAATAAT AATAATAACT ATTACCATTA TTATACCAGT 8281 AGCTGTCATT TATTTAGTGC TTATTATTTG CCAGTCACTG TTCTAAATTC TTTACATGTA 8341 TTATACAACT GCCATATAAC TGCCATATGA GGGATGTACC CTCATTGTCA CCATTTTACC 8401 GATGAGAAAA CTGGCATAAA ACGTTTAAGT AACTTGTCCA AGTTACAGAG CTTAGTGAAG 8461 CCACAATGTT GCTCAATTTG CTCTCAAACT TCAAAGGGAT GGGAAGGACA CCTAAGTCAT 8521 AGAGTCTTTA AGAATCAGAG CTAGAAGGAA TCTTAGATGT TATCTAGTCA GCCTCCTCCC 8581 ATTACAGTCC AAGAGAAGAT GGCCCTGAGT TACTTGTAGC TATTTTTGCA TGTGAATTGC 8641 AAGTGAATAT ACATTCTACT GAAGATAAAA GATATTTAAA GATATCGCTG GATATAGGAA 8701 CAGTGGTTTT AAATCTCTAG GCTTTAACTT TTCTCAGAAC AAGAAATCCT TTTTGGTTTT 8761 AATCTATATG CACATCTGTA TTTTTCTCAA TTATCGGGTA GTAAAATATA ACTTTTCTTC 8821 TGTAATATTT TTTAACTTTA ATGAGTGTTC CTCATAATAG AAAAGTTTGG AAACCATTGC 8881 TATGGGTATA TACTTTCTAA AGGGATAGTA ATTTCTCTAG AATATTCATT TAATGCTCCA

8941 GAAGTAATTA GCACAATTGT GCAAGTCTGT GCATCATCAA CTATACATTC TGCCTGTTTA 9001 CTCCAAATCC ACATGAAACT GATTATACAG TCAAAGGCGA GCCCAGTGGA GAGGCATTTT 9061 TGGAGACTTC CTGGTACATT GAGACAGGGT CGGCCAGTCT GCGTTAGGGT CTTGGTCAAA 9121 ACTGCATTTC TGAAACTAAA CTCAGATTGC TTTCTTTTAA GGGGTCAGAA CTGATTCAAA 9181 TCTACATTTT TAAAAGCCTT AGATGTGGGG CTTTTCCTAT TCCCAGTCTC CGCTATTGGT 9241 CTTTGTGAAT CCACAGGCAA TTTGGCCACA TCCTTGACTC TCTCTTATAT TAAGAATTAA 9301 ACAGCTAAGT TCATGCAGAG GAAATATAAC AAAGGAGGGA CTTTCCTACA AGATCTTTGA 9361 AAAATGGAAC ATTTGCATAA GTCATATTTA GCCAGAACTG TTGTTTTATA TTTTCCTTTC 9421 TGAATACTTT GTTACACCTC CTCCCAGCCA ACCCCCCCCC TCCCTGACCC CAACTAGTCA 9481 GAGACCAAAG CCTTCACAAT GGTTTACACT TGAACCTTCC TGGCCCCACC CTCATCATCA 9541 CGCCTGAATA ATTACATTCA CTGACTGGTC TCCCCTGCTT CCGTTTATCT CCACTCCTAA 9601 ACCCTCTGAC ACCTTAATCT TCCCAGAATA CCATTGTGAT CCTGTTCCAC TCTTGCTCAA 9661 GTTTTCCCAG AAACTAGAGT ACAAACTTTA TAAGCTTTAG AGTTGAAAGC CACTCTATCT 9721 CTTTTTCATC CCCAGGTCTC TGCCAAGGCA GTATAACCTG TCCAACATCT CTAACTTCAA 9781 TACCTTTGTC TTAGATACTA GACTCTCCTC CTGGTTTCTA ATTAAACCTG ATCTAGGATC 9841 TAATTTTGCC TCTGAATTCT GTTGCCCTTT GCCAAGTGAT CTCTTCCTCC TCTGAGCCGC 9901 AGCATCTCTG AGCTTGCACA CTTAGCATAG CCATAGCACA CACAGCCTTA GCTTGCAGTT 9961 CAGGGTGTTT ACCTTCCCTC CCCTTCCAGA TGCTGGATCC CCAGGGATAG GAACTCTGCC

10021 CTTATGTGTC CATAGCCCCT GGTAGTATGT CTTGCAGTCG TACATTTTCA GCAAATGTTT 10081 AATTGGTTAA TTGAAGACAA CTGTCCCATG CCTTAAGCCT CTCTTTTTGC TAAACATGCC 10141 TGTGTCCTTT GTCATTGAAC AACTATTTTG ATCTATTTTC TTCCTGACAT AGGGGTCAGT 10201 TCCGAGGATG CTGAAATCAA GAGACATAGC TTATTCTCTC AAAATTGCTT TCAAGAGTGA 10261 TTTTGTTGTG AATTGAGAAC TGGCTGCCTA CTTTTGGACT ACCCACTTCA GCAAGAGTGT 10321 TTGAAACCAA ATCTATTCTA AGTAATTTTT TATTCCCTTT TCTCTATGGC ATTAGACACA 10381 CAGCTCTTTT AAACTACCTT TCGTTATCTA TTAAACAGAC ATTCAGTAAC TCTATAGACA 10441 CTGTCTAGCT ATATGAACTT AGACAAACTA ATATCTCTGA GCTTCAGTTT CTTAAAATTT 10501 AAAATGAGGA CAATACCATC TATGGCCGGG GATTAAATGC TATGAGGAAT GTAAACCAGA 10561 TGTCAGGTAC CATCTCTCTA AAATCCAGAT AAAATGAATT AAAAATACTG GCCGCAAACC 10621 CTCTCTAAGA GTTCTCAAAA TTCTCAGAGA GCTTAATTTT CATGCTCACC ATAGCACCGA EPI-109 616

10681 TTTTCTTCTA AATATTTTGT TTCTACCAAA ATATTTTGTC CCAATTTTGC CTTTTATGGC 10741 TATTTCTTCA TATCCACTTT CCCAAACTAA AGAAGCAGCC CCTTCACCTT AAACTCCTCC 10801 TTCAAAGCAA CCTAAATACA GGTCTGGGTT TGTATTCCTA GTGGGATGTT ACAGAGGTTA 10861 GTGTGATGCA GAGGAGGAGT CATGCTGTTT AAATCCATAC TAGTCCCCAG AGGCCAGGCT 10921 GCTTCTGCCA CCCCTACCCC TCCCGCCACA GAGCTCTTCA GCTTCTCACA TTTCTAGTTC 10981 TTCTCTCTCT ACTTTCATTA CCTTCTCTCT TTTTTTTTTT CTTCTCATGT GCTCACGGGA 11041 GCAGAGAAAA TTAACTCCTC TAAGTTTTCT TAACACAGAG TGCCTTAATT ACATATTACT 11101 ATTGTTTGAG TTCCTGCCAA CACTACGTCT GTAGGGTCAC ACCTGCTATA TTAGAGGCTT 11161 ATCAAAAAAA GATAGCTTTC TCCTAAAAAG GGATTTGGAT GCCTACTAAG ATAACTGGAT 11221 GCCAAGATAA GTTTAACCTA ACAAACTTTA TTATTATTAT TATTATTATT ATTAGAGATA 11281 GGTACTTATT CTGTCACCCA GACTGCAGTG CAGGGATGCA ATAATAGCTC ACTGCAGCCT 11341 CAAAGTCCTG AGTTCATGCA ATCCTTCTGC TTCAGCTCCC TGAGTAGCTA GGACTACAGG 11401 CATATGCTAC TCTGCCCAGC TACTTTTAAA AAAATAATTA GGGATGGGGT CTTGTTGTAT 11461 TGCCCAGGCT CGTCTCAAAC TTCTGGTTTC AAGCAATCCT CCTGCCTTTT ACCTCCCTAA 11521 TTGTTGGAGT TACAGGCATG AGCCACAGCA CTCAACCAAG ATTTAAAAAC TTTTAAAAGA 11581 AATCACATTA CTTACTGTTA TCATCATTAT GGTTACTACC AGTGTTAAAA CAATTGGTAT 11641 TGAAAACACC ACTACCAGAT CAAGCTTCAA ACCAAGATGT CAAGTAAATA TTATTGTCAG 11701 ACCTCTGAGC CCAAGCCTGC AGGTATACAC CCAGATGGCC TGAAGCAAGT GAAGAATCAC 11761 AAAAGAACTG AAAATGGCCG GTTCCTGCCT TAACTGATGA CATTCCACCA TTGTGATTTG 11821 TTCCTGCCCC ACCTTGACTG AGGGATTAAC CTTGTGAAAT TCCTTCCCCT GGCTCAGAAG 11881 CTCCCCGACT GAGTACCTTG TGACCCCCAC CCCTGCCCAC AAGTGAAAAA CCCCCTTTGA 11941 CTGTAATTTT CCACTACCCA CCCAAATCCT ATAAAACAGC CTCACCCCTA TCTCCCTTCG 12001 CTGACTCTCT TTTCAGACTC AACCTGCCTG CACCTAGGTG ATTCAAAAGC TTTATTGCTC 12061 ACACAAAGCC TGTTTGGTGG TCTCTTCACA CAGACCATGT GACATTTGGT GCCGTAACTC 12121 AGATCGGGGA ACCTCCCTTG GGAGATCAGT CCCCTGTCAT CCTGCTCTTT GCTCCATGAG 12181 AAAGATCCAC CTATGACCTC TGGTCCTCAG ACCAACCAGC CCAAGGAACA TCTCACCAAT 12241 TTTAAATTGG GTAAGTGGCC TCTTTTTACT CTCTTCTCCA GCCTCTCTCA CTATCCCTCA 12301 ACATCTTTCT CCTTTCAATC TTGGCACCAC GCTTCAATCT CTCCCTTCCC TTAATTTCAG 12361 TTCCTTTCTT TTTCTGGTAG AGACAGAGGA AACGTGTTCT ATCTGTGAAC CCAAAACTCC 12421 AGCACTGGTC ATGGACTTGG AAAGACAGTC TTCCCTTGAT GTTTAATCAC TGCAGGGATG 12481 CCTGCCTGAT TATTCACCCA CATTTCAGAG CTGTCTGATC ACTGCAGGGA CGCCTGCCTG 12541 GATCCTTCAC CTTAGTGGCA AGTACCACTT TGCCTGGGTG GCAAGCACCA CCTCTCCTGG 12601 GGGGCAAGCA CCACCTCTCC TGGGGGGCAA GTACCCCCCA ACCCCTTCTC TCCATGTCTC 12661 CACCCTCTCT TCTCTGGGCT TGCCTCCTTC ACTATGGGCC ACCTTCCACC CTCCATTCCT 12721 CCCTTTTCTC CCTTAGCCTG TGTTCTCAAG AACTTAAAAC CTCTTCAACT CACGTCTGAC 12781 CTAAAACCTA AATGCCTTAC TTTCTTCTGC AATACCGCTT GACCCCAATA CAAACTCAAC 12841 AATGGTTCCA AATAGCCTGA AAACGGCACT TTCAATTTCT CCATCCCACA AGATCTAAAT 12901 AATTCTTGTC GTAAAATGGA CAAATGGTCT GAGGTGCCTG ACATCTGGGC ATTCTTTTAC 12961 ACGTCGGTCC CTCCCTAGTC TCTGTTCCCA ATGCAACTCA TCCCAAATCC TCCTTCTTTC 13021 CCTCCTGCCT GTCCCCTCAG TCCCAACCCC AAGTGTCGCT GAGTCTTTCC AATCTTCCTT 13081 TTCTACTGAC CCATCTGACC TCTCCCCTCT TCCCCAGACT GCTCCTCCTC AGGTCGCTCC 13141 CCGCCAGGCT GAATCAGGCT CCAATTCTTC CTCAGCGTCC GCTCCTCCAC CCTATAATCC 13201 TTCTATCACC TCCCCTCCTC ACACCTGGTC CAGCTTACAG TTTCATTCTG TGACTAGCCC 13261 TCCCCCACCT GCCCAACAAT TTCCTCTTAA AGAGGTGGCT GGAGCTAAAG GCATAGTCAA 13321 GGTTAATGCT CCTTTTTCTT TATCCAACCT CTCCCATCTC AGTTAGTATT TAGGCTTTTT 13381 TTCATCAAAT ATGAATACCT AGCCCACTCC ATGGCTCATT TGGCAGCAAC TCCTAGACAT 13441 TTTACAGCCT TGGACCCAGA GGGGCCAGAA GGTCATCTTA TTCTCAATAT GCATTTTATT 13501 ACCCAATCCA CTCCCAACAT TAGAAAAAGC TCCAAAAGTT AGACTCCGGC CCTCAAACCC 13561 CACAACAGGA CTTAATTAAC CTTGCCTTCA AAGCGTACAA TAATAGAGTA GAGGCAGCCA 13621 AGTAGCAACA TATTTCTGAG TTGCAATTCC TTGCCTCCAC TGTGAGAGAA ACCCCAGCCA 13681 CATCTCCAGT ACACAAGAAC TTCAAAATGC CTAAGCCACA GTGGTCAAGC ATTCCTACAG 13741 GACCTCCTCC ATCAGGATCT TGCTTCAAGT GCCAGAAATC TGGCCACTGG GCCAAGGAAT 13801 GCCCTCAGCC TGGGATTCCT CCTAAGCCAT GTTCCATCTG TGTGGGACCC CACTGGAAAT 13861 CGGACTGTCC AACTTGCCCA GCACCCACTC CCAGAGCCCC TGGAACTCTG GCCCAAGGCT 13921 CTCTGACTGA CTCCTTCCCA GATCTTCTTG GCTTAGTGGC TGAAGACTGA TGCTGCCTGA 13981 TCGCCTCAGA AGCCTCCTGG ACCATCACAG ATGCTTTTGG TAACTCTTAC AGTGGAGGGT 14041 AAGTCCGTCC CCTTCTTAAT CAATGCAGAG GCTACCCACT CCACATTACC TTCTCTTCAA 14101 GGTCCTGTTT CCCTTGTCTT CATAAATGTT GTGGGTATTG ATGGCCAGGC TTCTAAACCC 14161 CTTAAAACTC CCCAACTCTG GTGCCGATTT AAACAACATT CTTTTATACA CTTCTTTTTA 14221 GTTATCCCCA CCTGCCCAGT TCCCTTATTA GGCTGAGACA TTTTAACCAA ATTATTTGCT 14281 TCCCTGACTA TTCCTGGACT ACAGCCACAT CTCATTGCTG CCCTTCTTCC CAACCCAAAA 14341 GTGGCAACTC CTTTGCCACT TCCTCTCATA TCCCCCTACC TTAACCCACA GGTATGGGAC 14401 ACCTCTACTC CCTCCCTGGC AACAAATCAC ACCCTCATTA CTATCCCATT AAAACCTAAT 14461 CACCCTTACC TGGGTCAACG CCAGTATCCC ATCCCACAAC AGGCTTTAAA GGGATTAAAG 14521 CCTGTTATCA CTTGCCTGTT ACAACATGTC CTTTTAAAGC CTGTAAACTC TCCTTACAAT 14581 TCCCCCATTT TACCTGTCCA AAAACTGGAC ATGCCTTACA GGTTAGTTCA GGATCTGTGC 14641 CTTATCAACC AAATTGTCTT GCCTATCCAC GCCATGGTGC CAAACCCATA TACTCTCCTA 14701 TCCTCAATAC CTCCCTCCAA AACCCCTCCA TAACCCTTAT TCTGTTCTGG ATCTCAAAAC 14761 ATGCTTTCTT TACTATTCAT TTGCACCCTT CATCCCAGCC TCTCTTCACT TTCACTTGGA 14821 CTGACCCTGA CACCCATCAG CCTCAGCAAC TTACCTGGGC TGTACTGCCG CAAGGCTTCA 14881 TGGACAGCCC CCATTACCTC AGTCAACCCA AATTTCTTCT TCATCCATTA CCTATCCAGG 14941 CATAGTTCTT CATGAAAACA CACGTGCTCT CCCTGCTGAT CATGTCCAGC TAATCTCCCC 15001 AACCCCAGGA CTGGCAAATT GACTTTACTC ACATGCCCCA AATCAGGACA CTAAAGTACC 15061 TCTTGGTCTG GGTAGACACT TTCACTGGAT AGGTAGATGC CTTTCCCACA GGGCCTAAGA 15121 AGGCCACCGT GGTCATTTCT TCCCTTCTGT CAGACATAAT TCCTTGGTTT GGCCTTCCCA EPI-109 617

15181 CCTCTATACA GTCTGATAAT GGACAAGCCT TTACTAGTCA AAGCACGCAA GCAGTTTCTC 15241 AGGCTCTTGG TATTCAGTGA AACCTTCATA CCCCTTACCG TCCTCAATCC TTAGGAAAGG 15301 TAGAACTGAT TAATGGTCTT TTAAAAACAC ACCTCACCAA GCTCAGCCTC CAACTTAAAA 15361 AGGACTGGAC AGTACTTTTA CCACTTGCCA TTCTCAGAAT TCGGGCCTGT CCTCGAAATG 15421 CTACAAGGTA CAGCCCATTT AAGATTCTGT ATGGACGCTC CTTTTTATTA GGCCCCAGTC 15481 TCATTCCAGA CACCAGCCCA ACTTGAACTG TGCCCCAAAA ACTTGTCATC CCTACAATCT 15541 TCTGTCTAGT CATACTCCTA TTCACCATTC TCAACTACTT GTAAATGCCC TGCCCTTTTT 15601 TACAGTGCTG ATTTATACTT TTCCTCCAAA CCATCATAAC TGATATCTCC TGGTTTTACC 15661 TCAAACCGCC ACCCTTAAGT CTCTCTTAAA GTGGATAGAA GATCTTCAGT GACAAGGTAC 15721 ACTCCAATAC TTTCACCCTA ATAAAGCCCT ATTCTTTACT TTTATATTCA CTCTTATTCT 15781 TGTTCCCATT CTTATGCCAC TCTCTACCTC TCCCCAGCTA TCTCCACCAC ACTATCAATC 15841 TCACTCACTC TCTCCTAGCC ATTTCTAATC CTTCTTTAAC AAACAATTGC TGGCTTTACA 15901 ATTTCTCTTT CCTCCAAAAT CACCGAGTCC TCAATTTACT CACTGCTAAA AAAGGGGACT

15961 CTGCATATTT TTAAATGAAG AGTGTTGTTT TTACCTAAAT CAATCTGGCC TGGTATATGA 16021 CAACATAAAA AAAACTCAAG GATAGAGCCA AAAACCTTGC CAACCAAGCA AGTAATTATG 16081 CTGAACCCCC TTGGGCACTC TAATTAGATG TCCTGGGTTC TCCCGATTCT TAATCCTTTA 16141 ATACCTGTTT TTCTCCTTCT CTTATGCAGA CCTTGTGTCT TCCATTTAGT TTCTCAATTC 16201 ATACAAAACC GTATCCAGGC CATCACCAAT CATTCTATAC GACAAATGTT TTAAGGGAGG 16261 AGACCACCCC TCATATTGTC TTATGCCCAA TTTCTGCCTC CAAAGAAAGA AGTAAAAATG 16321 AAAAGGCAGA AATGAAATCC ACAGGCAGAC AGCCTGATGC CACACCCTGG GCCTGGTGGT 16381 TAAGATCAAC CCCTGACCTA ATCAGTTATG TTATCTATAG ATTACAGACA TTGTATGGAA 16441 AAGCACTGTG AAAATCCCTG TCTTGTTCTG TTCCTCTAAT TACCAGTACA CGCAGCCCCT 16501 AGTCATGTAC CCCCTGCTTG CTCCCCCTGC TTGCTCAATC AGTCATGACC CTCTCACGCA 16561 GACCCCCTTA GAGTTGTAAG CCCTTAAGAG GAAAAGGAAT TGTTCACTCG GAGAGCTCGG 16621 TTTTTGAGAC ATGAGTCTTG CCAATGCTCC CAGCTGAATA AAGCCCTTCC TTCTTTAACT 16681 CAGTGTCTGA GGGGTTTTGT CTGTGTCTTG TCCTGCTACA GTTTCATCTA ACAACCCCAT 16741 AATATCACCC CTTACCACAA AATCTTCCTT CAGCTTAATC TCTCCCACTC TAGGTTCTCA 16801 CGCCACCCCT AATCCTGCTC GAAGCAGCCC TGAGAAACAT CGCCCGTTAT CTCTCCACAC 16861 CACCCCCAAA AATTTTCACT GCCCCAACAC TTTACCACTA TTTCGTTTTA TTTTTCTTAT 16921 TAATATAAGA AGATAGAAAT GTCAGGCCTC TGAGCCCAAG CCTGCACGTA TACATCCACA 16981 TGGCCTGAAG CAAGTGAAGA ATCACAAAAG AAGTGAAAAT GGCTGGTTCC TGCCTTAACT 17041 GATGATATTC CACCATTGTG ATTTGTTCCT GCGCCACCTT GACTGAGGGA TTAACCTTGT 17101 GAAATTCCTT CCCCTGGCTC AGAAGCTCCC CCACTGAGCA CCTTGTGACC CCCACCCCTA 17161 CCCACAAGTG AAAAACCCCC TTTGACTGTA ATTTTCCACT ACCCACCCAA ATCCTATAAA 17221 ACAGCCCCAC CCCATCTCCC TTTGCTGACT CTATTTTTGG ACTCAGCCCA CCTGCACCCA 17281 GGTGATTCAA AAGCTTCATT GCTCACACAA AGCCTGTTTG GTGGTCTCTT CACACCGACA 17341 CGCGTGATAA TTATTATATT ACTTTTAACT AAAACCCTTT CAGAGTCTCG CAGGGAAGGC 17401 TGTATATATC TCATAAAATG TTGGGGCCCA CTGGATCAGA CAAGGCCACA AAGGCCAAAG 17461 GGAAGTAAAG ATCTCATTAT TTCTCCTAAT AATTTCCCTG TCCTTTGTCA TAAATGGTGG 17521 GTAGGCTGTT ATGGTGATGG CAGATTTTCT TTCCATAAAA TGTCCATAAT AGGACATTTG 17581 AACAGAAGGG AAAAATCAAA TTGCTGAAGT TGAAAGAGGG CAATGCAAAG AACTTTGGAG 17641 AAAGAACTGT ACAGAGAAGT CAACTGGCAG ATGGGAGGAA GTTTAAGGGG AAAAATATAG 17701 ATGTCTAAAG AATACATTTA TTCATTTTCC ACAGTGCAAT TTGGACAAGA AGCCTCTTTC 17761 TTGCTTCTTT CTATTCTCAT TAAATCATTA GAGCTCAAGC AATCCTTCTG CCTCAGCTTC 17821 CCGACTAGCT AGGACTACAG GTATGTGCTA CTATGCCCAG CTAATTTTTT AAAAATTAGA 17881 TTTTAATTTG GTGAACTATT TCTGTAGGAA ACTACAATAA TACAGCCCAG GCACATTGAT

17941 CTTGGGTGAA CAAATCAGAA GGAATGAATA ATTCTGTGTT CCTGGGACTC TGACAATTTC 18001 ATGAACTTGG TACTCTGAGT AAAGCATAGG AGGAGTTATT TCATAAAATG TGGAGCACAA 18061 TCATGTGACA AAGATAATGG GATCCCCATT TCATAAATAA ATCTGAAGTT CAGAGAGAGT 18121 AACAACTGGC CAGGGTCACA TCACGGAGAC AGAGGCAGGG TTCCCACTGA TGCCTCTGAC 18181 TCCCTGTCCC AGGCCCTTCC TCCTCCCGCA AGCAGAAGTG CAGGGGGCAG AGCTGACCCT 18241 GTGCAGTGAA AATCTGAGGG CTGAGTTCCT ATTGGAACAC AAGTGAAAGA CTTCCTGGCT 18301 TCTAATCTCA GGATAAGGAC TCAGAGCTCC ATCTGTTCCA GCCTTAGGAT AAGAACCAGA 18361 ATCTTACACC ATGAAAGCAT GAAAGGTAAG ATTTGAGTGA GGAAAAAAAA AAAAAAAGTC 18421 TGTGTTTCAG ATTCAGTTCA CAAAGCAGTT TCATACTTAA GGTACCATCA CAATAACCCT 18481 GTGGGGTAAG CAAGGCAAAT TTCATTCTTG TTTTATGGGC ATAGGAAGTA AGTCTCAGGG 18541 AGGTTAAGAC CAAGGTTTCT GGAGAATTTT ATATTATGAA TCTTGATTTA TGGGATTACT 18601 ATTATGTAAT TCCTAAGATC ATATAGGAAT CCTAGAGCTT GAATATAGAA CTTTATTTTT 18661 AAATCTATAT ACATCATAAT TACAAGGAGT AGTGTCCATT TGGGTTCCTT GGCCCTGATG 18721 TGTTAGTGGA ATAAACATTT TTGTCAGGGT TGCCATGTGT GTCTGTGCAC GTGTGCACTG 18781 TACACCTCCA GGGGATGTAC CCTAAACCAC ATGAATGTGA TTTGCACATC CAAGATTTAC 18841 AGTGTACTAT AGGGAGAATC TTTTGCAACA GCTTTTGCTA TAATACAGAA TCTGAGATGT

18901 CTTTGAGAAA GAAAAGTGTA ATCATTACCA AAAAATTATT CTCATAATGT GTGCAAATTT 18961 GTATGAAATC TATATTGGCC ATGGGACAAG GAGGTATTTC CAGCTAGCTT CTGAAAGGGC 19021 TCTATTCTCT CATAAGAATT CAGCTGTTGA CATTAGGTGA TATCTGCCCA GGTCATCAGA 19081 TGCCATAGAG AAAGAGGGTT TGCTGAAACT TATATCAGCA GTGCACTGTA TGCTCTTTCT 19141 GATTTATTTG AACATTCATT TATTGAGTGT CAAGTAATGC ACTAGATACT CCAGGGATCT 19201 GACACAAACT CTGCCCTGAA GGAGCATGTA ATCTCACTGG GGAGAAAACA AAACATATGA 19261 TAATTTCAAA ATAACAAACT AGGCAAACTA GTTAACACTT AAAAAGCAGG CTTTATTCAA 19321 ATGCAAAATT GCATGTTACA GGGTAACCTT TCAGTAAGAA GCCAGGAAGA GGAGCTCATC 19381 ATGGGTTGGA TTAGTAAAGG ACTAGTTATA AAAGAAGTGG TGGGGTTGAG GGAGGCCTGA 19441 GATGAAATTT AAAGAATATG TAGAATCTAG GTAAGTGGAT AAAAGGTCTG GGGGCAGGGG 19501 AAAGGAGAGC ATTTCATTGT GAATCAAGGA ATTTCTCCAC CTGTTTTAAC TCTTCCATAT 19561 GACATCAAAG AGATGTCACT TGCAGCTAGC ATTTCAGTGA TGTTTTCTTA CTAATAATAT EPI-109 618

19621 CGTGATAAAA GAAACATTGA CTATAAGAAA TAGGAATGGG TCTCATAAAA GGAAACAGCA

19681 AAACCCCCAA ACTAAAAAAC AGCGCAGGCT ATTTCTCTCT TCTCTCCTTT TGCTTGGCAC

19741 TCATGAGATG CTAGGTGTGG AAGTCAGCCA ACTGAAAAAG AGAGGTGGCT GAAGAAGGTG

19801 GGGAGGCTGA AGCCAGTTAA ATAGGATGGT CCAATTCACA GACGGCGAGG CTACAGTGCA

19861 AATAGGACTC TTTCAACTTG AGCAGGACCC CATTACTTCA CTGGAGTTAG AAAGAAAGGA

19921 GAGCGTAGAC TTTTTGAACT TTCTATAAGA GTGTACCTCC ACAGTATACA GAAGACGACG

19981 TGAAATTTGA TCTGCAAGAA AACTGAGTCC ATATTCACAT ATGTATCAAA TTTGCACTTC

20041 ATTTAGAAGT GTCTGTCATC AAGTACAGCA CTGAATTGAA ACTGAAAACA AGAGTCAAGA

20101 AAGAGCAAAG TCAGCCATCT TTATATTCCA CATGAATCCT TTCCCTTTAT GGTCTTATTT

20161 GTTTCTCCTC AGAAAAGACA AAAAGCTGAG CTGTATAAAC ACCTGTGGGC TGGGGGTTGA

20221 GGGATAAATG AGGGGCGAAA TGGAAGCTGA AGGAACTGTT GGTCAGGTAG AAATCTTCCC

20281 AGATGCACTG AAGGAAACAC ACTTCATGTT TGACGTAGGA GGTGCCACCA CACAAAACGT

20341 TTCATGGAAG GATTTAAAGG ATCTCATGAT TTTTAGTATT CCAAGAATTT TCTTTCACCA

20401 AGGGCGATTT AATATGGGTC ATTCATACTG AAAGAAAAAC AAAAGATAAT AAGAGTTTAA

20461 AAATTGCAAA ACTTGGAGTG TTAGTAGTAA AGGTAAATAT TCATTAGAGA TGAGAAGAGG

20521 AGCAAGGAAA TGCTTTCAGC TGGAAATCTC AGACAAGAGG CCAGGCTTTA GGAACCTCTG

20581 AAGATGAACA AATGTAAGCA AACCCTAGTA GCAGCACTTC TCAGATTTTC ATGTGCTTAC

20641 CACTCAGAGA TGGTGTTAAA ATGCAGACTC TGATTCAGTA GGTCTGAGTG GAGCCTGAGA

20701 TTCTGCACCC CTAACAAGCT CTTTAGTGAT GCTTATGCCA CTGGCGCACA GACCCCACTT

20761 GGAGAAATTT TTGTGGTGCA TACGGTCTTT GTCTCCAGAT CTAATGAGTC TGAAGGACAG

20821 TGTAGATTGA TTTTTTAAAT TTATGTTTAT TTTAATTTAA TTTAATTTAA TTTATTTATT

20881 TATTTATTTT TGAGATGGAG TCTCACTCTG TTGCCCAGTC CGGAGTGCAG TGGCACGGAG

20941 GCAGCTCATG CAACCACGGC CTCCTGGGTT CAAGCGATTC TTCCGCCTCA ACTTCCTGAG

21001 TAGCTGGGAA TACAGGCACG TGCCAGCACA CCCAGCTAAT TTTTGTATTT TTAGTAGAGA

21061 TGGGGTTTCA CCACATTGGC CAAGCTAATC TCAAACTCCT GACCTCATGA TCCACCTGCC

21121 ACGGCCTCCG AAAGTGCTGG GATTACAGGC GTGAGCCACC GAGCCCAGCT GTAGATTGAT

21181 TTTGAGCAGT GGAAAGTCAA GGAATTAGAA GGCATGCTTA AATGGAAAGT GAAATTGGAG

21241 AAAATTTAAA CTCATGAAAT AGTGGTGGTT ATAAACTCGT GATAAATTAT ATCCTGGGAT

21301 ATAATTTAAT GAGATGGTAA CACATTTAGT TTAAAGAAAT AAGTGACACT TTTTTTGTGT

21361 GACACAACTG TCTTATTCTT GGAAAGGACA AGGAGAGAAT GAAATATGGT ATGTCTTCAC

21421 AGCACCTTTC AAAGGGAGAA CCAGATTCTG AGGAGCTGGT CTCATGATGA ACTGTCAGGG

21481 TAAACCACAG TTCAGCAGCT GCAAATGTGC TTGCCAAAAT AGAGACAAAA AAATGTTTCT

21541 GAAAACAAAA TTTCACATAT GCCCTCCTCT GAGGTTGGCA TCATATCTTC CTGTGTATCT

21601 TGGGTGTAGC TTCTATCCTG CCAGAATTTA GACAGTAGAA ACCAAATGAG GTGATAAACA

21661 GAGTCATTTT GCAGAAGAGT CAAAATAACC CAGCAAGAAA TGAAACCACA AATGCCCAAG

21721 GAGTCATTCA TTCACCATTC AAAAGCTAAT AGAAATGAAC ACAAACTACT ATGAAAATTC

21781 ACCCAAGAAC TTAAAAAAAA AAAAAAAGGC TCATGGTGTT TAGTGTGATA GTATTCATTT

21841 TACCTTTGAC TTGTTCTAAA AACACACCAT ACTTCTACCC CACCCTTCCT CAGTGCCGTC

21901 ACACAATGGT TTCAGTGTGA AAAAAAAAAC CACGTTACTG GAAAAGGAGG GTGCCTGGGA

21961 CTTGCCACTC TAAGCTGGTA GTCAAGGGTC TTGAGTTCTA AAAGCATACG CGTTAAGAGC

22021 ATGATTCCTG GATCCAAATG AGTATGGATC TCAGCATTGC CATTTATTGT GACCTCAGGC

22081 TATTTTATTT CTCTGTGCCT GTTTCTTTAT CAGTAATGAA GATGTTCATA GACCCTTCTC

22141 CCACAGACTT AAAGGCATAT TTCATGATTT AAGACATGTA AACCATTCAT AACAGTATAC

22201 AACATGGAAT TAATATTTGA TAAAGGTTTA TGATTATTGT AACTAACTCT GTCACTTGCT

22261 CAAGGCCTAT AGAAAACTTA CTTAATTAGT TCAACTACAA AAAGAGTTTG AATGTGATAT

22321 CCACCAAGAT CATATTCAGA CCTAGAATTC TGTGATTCTT ATGAATTAAT ACAGCCTTGG

22381 TCAATAAATG AGAGCTGGGC AAATAATTCT TCTTTGCTAG GCCTTTCTAG ACCATCTGGT

22441 GAAGCATTCA AGACTTATGT TATTGGGGCC AGCCTTCCTT TCCAACTTCA ACTCCACAAC

22501 TCCTCAATAA GCCATGGGCT CAAGAAAGTT CTGCTCAGTG GCCCCTGAAA AATGCTTTCA

22561 TAGTCTCACT ACCATACCAC TGCTTACACA ATTTCCTTCC TACAGACTGC CTTCCTTTCC

22621 TGCTTTTCTC CATATACCTA AATCCTATCT ATTCTTCATA AGCAACCTTC TTTATAACAT

22681 TTTCTATAAC CACCAAGCCA AATGACCTTT TCCTTCTTAA ATATAGCACC CATTGGCCAT

22741 TACCATGCTC TGCCTTGTAT TTTTCTGATT TTTTTCTTTC TATATTCCTG TCTTAACTCC

22801 CCAGCTAGGT AATAATTTTC CTGAAATCAG GGACCAGGCT GACTCCTCTT GCTGTCTCAA

22861 GAAAGCTTAG CAGTTTCCAA CACAAAAATG TTCAATAAAC AACTATTAAT TGACTGATTA

22921 TAAAAAATCA GTGAACCATT AAACTTAATA TAGCAATTTG CTTAGCATGG TAATTAGCTT

22981 TTTGCTAATA TTCTTCCAGC CAGTCTCTCC TCCTGTGCCT CAAGGACATC TTAAAAAAAA

23041 AAAATCTAGT TGATCTGCTT CCATCTAGTG GCAATTAAAA CAGGTGGTTC CGGTAGCCAG

23101 AAAACAGCTC TGGGTAGATT GTGCCAGAAA ATACTTTCAC TCAGTAGGTG CGAGTTTGAA

23161 AGAAATCTTC ACATCTGTG^'G GTTTCCTGCC ACAGACATAG GGAGACCAGC CCAGAGAAAG

23221 AAGCCTTTCC TCACTAGACT CCATTTGCAC TAGTAAAGAG AAGACAGAGT AATTAAAAAG

23281 AATAAAAAGA ACCTCCACTG ATCGTACATC CTCATCCAGT TACCCCTGCC CCACTTCTCC

23341 TTCACAGCCA AACATTTTAA AAGAGATGAC TGCTTGTTCT GTCTCTACTT TCTCATCCTC

23401 AGTAATGCTC AATGCTTGGC CGTCTGACCT CTGTCTTGAT GTCTGCACTG CAAATAGTCT

23461 CCCCACTGAC ACCCTTGTTG CATCCAGGGG ATACTTACTG GTTCTCTTGG CAATGTTTGA

23521^' AACCGTTCCC CTTTCTTTGT TTCCTTGGCA TTCATTACCC CACACTCTTT CTCCTCTTCC

23581 TTCTCCCTGC CTGGCAACAT CTTTTCATTT CTCTTTCCCT TAGGTGACTT ATTAGATAAT

23641 GATGTTCCTC TGGCTCCCAT ACTCTCTCCC AGGTCCTCTT CCATTCTTAA AGCACTCACA

23701 CCCTCCCTGG ATGATAGTAC CCACTCCTGA GATGGCAGTT ACCTCCTGAA ATGTGAGGGA

23761 CCCAAATCCA CTTCTCCTGC CATAGCCTCT GTGCTTTGGA TAGGTCCAAT GAGCCACAGT

23821 GAATGATGTG CATACACCCA AAGCTCAGTA CAAAACTGAA CCCATGATCT TTACCTCCAA

23881 AACCTCTCAT TCTTTTATGT TCCCTTCTCA GAAGTAAACA GGACTACCAT CCGCCAGTTT

23941 CCAGGTGAGA AAGATGATAA TTTGATTCTT CTCTCTCACT TTTAGCCAAT TAACAGACAC

24001 ATTCAGTTAA TATCACCTCC TCTTATTTCA TGAACCCATT CTTACTACTA GTTCCCTAGA

24061 CAGGCGCCAT CGGTTTTAAT CTAATAACTG CAAATGCCTC CAAAACAAGT CTCTTTGAAT EPI-109 619

24121 CCAGGCTCAC CTGTCTCCCA CACTTGCCAT ACTGCTCTGC AGGGTGACCT TATAAGATGC 24181 CAGAGGTAAG GCTACTCACT GTTTAAACCC CTTTAGTGAT ATCCCAAAAG ACCTCAAGAT 24241 AAAGCCCATA TCACATGGCT TATACATTAG TTTATGATCT GGCTTCTGGT GCCTCATTTT 24301 TCCCCACTTT TTCCTTTGCA TTCTAAGCAA TGGCCCATAC TAAGTTTGTG ATTGGTAGGA 24361 TGGTTGCCCA AACCAGCATC CAATCCCTTC AGAAATCATC TCACTTCATT TCTAGCATTT 24421 TAAAGGAAGC TCAGTTGTCC AGCTGGGTAC TGAATATGTC ACCAAAGTCC TCCTTTCATA 24481 GTTTATTTTA CTTAAACTCT CCTTCCTAAA ATTCCAGAGC AAGTCACTAA ACCCTAGATA 24541 CTGAGAAATA TTTTTCCATC TTCATTTCTG CCAGGTGGGC CATCAACTTT CACATGTCTG 24601 CATCTCCTCC CACTGTGCTA TTTCTCCAGT AGAAGAAATT TGAGCTTCAA GACCAAACTG 24661 AAAAATACTT GCCTCCTTGG GGAAGCTGTA GGTAGAATTC ATGCTCCCTA TCTTTCCCAC 24721 ATTTCTGAAG GACAATGCCT GTTAGAGCAA TTGAATGCAA ATAGTCAATT GAATAAGCAT 24781 TTATTCATTT CTCAATAAGT GCTTGTTCAA TTGAATATTT CTTAAATAAT ATATTTAAGA 24841 ACAAGAAGAA CACACCACAA TGTTTTTAAC CCTCAGAAAA AATTCTGAGG TAATCAGAAA 24901 AATCTCCCTT TACATAAACT GCCCTTTTCT AATAGGGATT ACTTGTTCGT TCATTCATTC 24961 ATTCAGCTCC ACTAGCACCA AAAAGCACAG CTCTGAAAGG AAGCTAGTAG ATTTATCACC 25021 TTATCTGGTC ATTTGGATGA GGACCCCAGG TAAATAAACT ACTATGGGGT TAATGTGTCT 25081 AGCTAGAGCA GGAAGTAACT TAAGGAAGTA GAGAATGAAT CAGCAGATGT GGAAACTCCT 25141 CGCCACTAAT AAAACTTACC TTCTCTTGGA TTTCTTGCCT GAAAATAGAA AATAGAGAAA 25201 AGGCATTAGC AAAAATTAGA CAATTTAAAG TTTTTCAAGT AAGGGAGAAG GAAGACTCCC 25261 ACTCTCAAAA CTGTCTTTTG AAGTATATTA GGTATTTGTT AGGTGGACCC TATCTGTGTC 25321 AAAGGAGATT TGAGGAACTG GCTTAATAAA CAGTGGTAGA CACTAATACA GAACAGACAT 25381 GTTGATGCAG ATGCCTCCTG AGGTTCCATT CCATTCTCCG TGCTACTCAA GAAGACAGAA 25441 TTGCTAAATT GCCTGGTGGC AAGACCCAAT ATGTCCATTC AAGTGTTTAT CCCTTCCCAA 25501 TCTGCCATCT CATCCTACCT GCAGATTCTT CCCTTGAGGG ACAGCTGCTA ATACTGTAAA 25561 ACTATGTGCC ATTACAGCTC ACAGCATCAT CTCTATGAGA ATCCACAAGA GAATTTCACT 25621 TTGGTCTTGT TGGTAGGAAT TGTGCAGCCT CATCTGAGTA ACTAATGTGT TTTTATCTTA 25681 CAAACACAAG GAATATCACA TGGTTCTCCT TTGACTGGCT GTAAGGAAAC TCAGAGCTAG 25741 ATCTGAGACC CTCTCCTACC AAGTATATAA AACTTTGTGA CATACATTTT TGTGCCATAA 25801 CTTCAACCTT GGTTCCAAAT GATTTTTGTA CCCTAAGTTT AAATTTGGCT TTCTTTTTTT 25861 TTTTTTTGTA CTCAATAAAA CATCAAGCTC ATTTATTATT GCGAAGAGCG AAACAACAAA 25921 GCTTCCACAG CGTGGAAGGG GACCCGAGTG GGTTGCCCAA ATTGGCTTCT TTTTCTTACT 25981 TTTTAATTAA TTTTAATTTG CTATACTGAA CACATTTTGT ACTGTTCTCA CATTCTTTTT 26041 GAAAAAAGCA GAATATAAAT AAGTAGATAA CTTAAAAAAA ACTCTTTGAG CAGAAAGAAT 26101 CATTTGGGAG GCAATATATT TCAGTGGCTG TAAAGTGGCA TTCTAGAATC ATCCTACCCA 26161 GGTGAAAGCC CTATTTTGCC ACCTGTAGTG TAGTGTGTAT TTGAACAGCT ACTTTCTTTT 26221 CTAAACTACA ATTTCTTCAT CTGTTAAAGA GGCATAATAA TTGTATCATC CTCATTGGGT 26281 TGATAAAATA AAATATTTCC AAGTATTTAG TTCAGGTCCT AGCACGTAGA CAGTGTTGCA 26341 TTACTGTTTT AATCCTTTAA AGTATTAAAG ACTACTATTT GAAATCTTTT CTTCTAAAAT 26401 TCAGCCTGCT GATGACCAAG TGCACTTGAG CAGGGGGAAT CAAATCTGAA TTAATTTCAG 26461 ATTCTGGTTA GCTTCACATA AATATTTTTT TTAGGGATGA TGAACCTAAC AGCAATAGAT 26521 GAGTAAGAAT CTGTTCCTAC TGAGAGAGTT TCATTTTGAA GAAAAAGGAA CTAAGGGGGC 26581 ATGTGTTCAG TTTCATGCCC TGGTCTAACC CTGTGTGTTG GTTCTGGTGG GAAATTCTTC 26641 CAACCGAGGA AAAAACCAGT TCACAAATCT GAAGACCAGT GATTTTAGAA GATGTATCTG 26701 GACTGGAGTC TAATCTCTGA CTCTGGGTCC TGCTGATATG GTATTTTTGA GATTTGGCCT 26761 AAAACATCAT TGCCCTGGTT TCCTTATTTA CCAAACAGGG CCAATGGTAG TGACTAATCA 26821 GAAAATGATA ATGCCTGGTG CACAAAATGT GTCTAGATGA GCCCATGCAC AAGGACACAT 26881 GTTTCTGGAA CTGTTCCTTA TTCCTTTCCT AAAAGAAAGG AGGGAAAGTC TCCATACTAA 26941 GACTACTAGG GCAGGGGACA AAGTGCTAGA GTCAGAAGAT TCATCTGAGG ACAGAAGAAT 27001 AGGGGTGAAG GCTCTAGTCA CTTCATTGGC TACCATGCTC TAAATAGTTA CCTGTGCCCT 27061 TTTTCTAACT ATTAGAACCC AAAAAGCCTA TAAATTCTCT CTCTCTCTCT CTCTCTCTCT 27121 GTGTATATAT ATACATATAC ACACACACAT AGACACACAC ACACACCTAA ACACACACAT 27181 AGAGATTTAT GACTTTTTAC TTTTATCCTT GTAAATGCCA TTAACTATAT TTTGTCTTAG 27241 ATTTAGCCTG GGAATGTAGC CATTATTTCT ACCATTGCCT CCATAGGAAA AATACTCTTC 27301 ATGTTTTAAA GGACCAACCT ACAACTAAAA TCTTTGGAAA GCAGAATCAT TTGTAAGTTG 27361 GTGAAAATGG AAGATGTTGT TTTATAAATG AAGACTTTTT TTTTTTTTTT TTTTGAGACA 27421 GGGCCTCACT CTGTTGTGGA GTGCAGTGGT GCTGTCATGG CTTACTGCAG CCTTGACCTC 27481 CTGGGTTCAA GTGATCCTCC CACCTCAGTC TCCTGGGTAG CTGGGACTAC ATGTGCATGC 27541 TACCATGCCT GACTAATTTT TTGTATTTTT GTAGAGATGT GGTTTCGCCA TGTTGCCCAG 27601 GCTGGTCTTG AACTCGTGGG CTCAAGTAAT CCTCCTGCCT CAGCCTCCAA AAGTGCTGGG 27661 ATTAGAGGTG ACAGCCAAGG TGCCTGGCCC ACAGATGAAG ACTATTTAAT GTTATCTTAA 27721 AGATACCCTA AGCTTCCTAC CAAGCCAGTG ATCTTTTGGG GCTTCTGTTT TCTTTGTTGG 27781 CATAACTGTA ACTAGCCTAA CTGCCCGTTA TCTGTTTCCT GTTTGCCCCA CACTGATTCC 27841 CACAGCAGTT TTCAAGTTAT CGGTTTGAGA TCTTGTACAG AAATGACTCC AAGGTAAAAA 27901 ATTTAAAAAC AACCCCTCTA ATTTTTTTAC CCTTGCTTAT AAAACAGCCT TAGCCAGCTA 27961 ACCCCTCACT ACATGCAAAT GAGTTTGATT CTATTCTTTT GATTCTACAA ACACTTATTA 28021 AAAGATTTTA GAATTCGGAA ATAAATAGCT TCCTTATTAA GGTGACTTAC AGCCCCAAAG 28081 TCCTTAAAAT TATTTAGACA ATAGCCACCT TATCCCAGGG GGCAGTGTGT AATAACCCAC 28141 CCTGTTCTCT ATCCGTCAGT TCTGCCATCA TCGCCCAAGG TAGGAAGAAA GACAGGACAA 28201 CCGGGGTCAA GATTTGAAGT CTCAATGGAA AGAATAATCA GTGGTTGGAG AAAACTGTCA 28261 TTCTTGTTTT GCCTTAATGC AGTACTTGAT ACTTATACTT AGTACTGTAT AGTACTTAGT 28321 ACTGTATAAT ACTATAAGAT AGTGAGATTC AATCAGCACA GAATTTCTAA TAGCAAGGGC 28381 AGAGACATTT TAACTGCTCA GTGCTCTCAG GTTATACATA GCTAATGAAG TTCTTGCATA 28441 TCAACAATCC CCACCCCCCT CACACACTTT GTCTTTCTGG ATTGGTTAGA AAACTTACCT 28501 AGCGCCCACT ATTCTCAAAT TTAAATGAAA GATAAGATCA GAGTGGCACG CAATTAGGGA 28561 CTGATAAATA ATATTTTTGT AATTGCCAGT GTAAATGGAC AGGGGGCAAC CTTTACATAC EPI-109 620

28621 CATATTCAGT GAACAGAATA CGTACTAACT AATTTGATGG AAGGAAAATT AAAATGACAA

28681 TCAACTGAGC CCACAGAAAG GCAACACAGA GCAGTTGGTT AGCAATTGTT TCGAGATCAT

28741 CCCTGAACTT GAAACAGGTA TATCTTTTTT TTGAGACAGA GTCTCACTCT

28801 GTCACCAGGC TGGAGTGCAA TGGTGCGGTC TCAGCTCACT GCAACCTCCG CCTCCCGGGT

28861 TCAAGTGATT CTTCTGTCTC AGCCTCCCGA GTAGCTGGGA TTACAGGTGC CCGCCACCAC

28921 GCCTGGCTAA TTTTTGTATT TTTAGTAGAG ACAGGGTTTC ACCATGTTGG CCAGGCTGGT

28981 CTTGAACTGC TGAGCTCATG ATCCGCCCGC CTCGGCCTCC CAAAGTGCTG GGATTACAGG

29041 CATGAGCCAC CACACCTGGC CAAAACAGGT ATATCTTAAA AGCTGCCCAA TGTCCATGAA

29101 TGTTACAGCC TTGAATGGTT CTTCCAGGTG AGTTTGGCCA AATGTGGCAC CATACACCCA

29161 AGGCCTGCTG CAGGCTAGTG GGTTGCTCAC ACTTTAAAGC TGAGACACAC TCATGCCTTA

29221 AGGTAAAGGG AGTGATAATC TGGGCAGCAG ATGTTAACTT CTCAAGGCAG TCCTCCTTCT

29281 CTTTTCCTCT CCAGTGACGG ATGGTTGGAA AGCATATATG GTGCATTTGG TTAGAGCTGT

29341 GGCCTTGGTG AATAGATACT TGGGAGAATA CATGGGAATT TCTCCCAGGG TTAATGCAAT

29401 GCCCATGTGT TGGGAACCAG GTGACTCTTG AAGAGGTCAG GTATTTGGGA GCAGTGCCTT

29461 GAAACCTTAG TGGACATTAG ACCCACTTCC TAGTGGAATT GTAGCATTGA AATCCAAGGC

29521 ATGTAGGCTC TTAGAGGACA GAGATAGTGT GTCATTTTTT CAGAATTAAT TAAGAGCAGG

29581 CCAGGCGTGG TGGCTCACAC CTGTAATCCA AGCCCTTTGG GAGGCCAAGG CAGGCAGATC

29641 ACGAGGTCAG GAGATCGAGA CCACTCTGGC TAACACAGTG AAACCCCGTG TCTACTAAAA

29701 ATACAAAAAA TTAGCTGGGC ATGGTGGCAC GCTCCTGTAG TCCCAGCTAC TTGGGAGGCT

29761 GAGGTGGGAG AATAGCTTGA ACCCAGAAGG CGGAGGTTGC AGTGAGCTGA AATTGCACCA

29821 CTGCACTCTA GCCTGGTGAC AGAGTGAGGC TCTGTCTCAA AAAAAAAAAA GTATTAAAGA

29881 ATTACATAAG AGCAAAGAAC CATTAGAATA TCTCACTTAG TTGTTATCAG CCTAGCAAGC

29941 TGCCTTGAAG GTAATAGACA TTTTTAAAAG TTTATCAGAT GAAAAGCGAA AATCAGCCAA

30001 CCTGTTTTAA TGAAGGTGTG TCCTGGGCTG ATTTACATGT CTCCAGGGAC TGATGGCTCT

30061 AGAATGTAAA GCTTGGCATC CTGCTTGTGT TGAATCTATC ACATTTAATT TCCTGTGGGT

30121 TTCTTTTTTT TTTCTTTTTC ACTTTAAAGT TGTGTTCTTT TCATGTGAAG TTAAACTCAC

30181 ATACCTTTTT TTAATCTCCT TGCCAGCCAA ATGATAAATG CCAACCCAGA GAATGCAGTA

30241 ACCATGACTG CCACTGGAAT GAAGAGGGGG TTATAATCAC CCTCCTTAAT CATTGAGAAA

30301 CTTTTGTCCA ATTCTGAAAG AGAAATCAGT AAGGCACATA GCATGAGACC ACCAGCATTA

30361 TTTCCTTAGT CTATCTCATG ATATTTGACT TTTTTCCTCC TTACATCTCC CAGTAGTAGC

30421 CCATTTGATG CCATTTGACA GATGAGGAAA CTGGCATGGG AAGGCCCCTG ATGAGTCTAC

30481 AGCATAGGCA AAGACTGGAC CAGCCTTGCT AGTCTAATGC CTACAGAATC TCAATGCCCA

30541 GATTTGTGGT TCATAGAGTT CCTGAAAATG CACCTAAAAA TGTTGGCAAG AATGGTCATC

30601 GTTGTATTTA GCTCCATGGA CTTGTTCAAT GACTGGAACT CTGAAACACA GAGAAGAGCT

30661 AAAAGCCTAA TACAACTTCA GGAAAAATAA AAGCCAATGA TCTGAACTGG ATAATTCACC

30721 AGTCAAAGGA AATCATTAAT GCTTTTACTT TAAAGCAGTT GTGCAAAAAT AAGCACTTGA

30781 TTTTTACATG CCAAGGACCT GCACTAATTT CTTTCCAATG CAGTAGTTAC CACTTCCCTC

30841 TACTTCCTTC ACGAATAAGT AAAAGGGCAT GTTTAGAGAT ACTCTTGTAA GTGTAAACTA

30901 AGTTCATTTG GGAGCCTCTA TTTGAAAATA CTGGTATAAA AAAAAATCTG TCTCCTGATA

30961 CTAACATTTG AAGGAATCTA CTTTTTTACA TATTGGCAGA GGGTCTGATT CTATCCTTAG

31021 TTCTTCCCAT TACTTTGATG AACCTTTTCA AGGTGATTTG ATCCCCACAC CCAAATATAT

31081 GATTGAGAGA AGGCTCAAGT TCCCAGGAGC TCCAGACAGA AGGTACCTGT TGGCTTGATG

31141 AAGATGAGGA GGAAATGAAC ACTAGCTAGG CCTTAAAGGG AAATGTCTCT GATAGGCCTA

31201 ATACACAGTC CTCTGCTAAA GGCCTCCCTG CCTCTCTCTG CTCATCCACT CTACTCCCTG

31261 GCCCTGGGCA CGCAGCACAC AGAGATCAGC ATTTCTGACA GCTTCTGTAG ATCCTACCAT

31321 TTAAAGACTT TTGTCATCCA TGCAGATAGT CTCAGGAGCA GACACAGGTA GCTATTCTTT

31381 CACATGCTAG CTTAACATGC ATTTGCTTTA GCACCTATTG CCAGGCACTG TGTCAGGTGG

31441 AGGGTATACA AAGATGAACA AGACATGATT CTTCTCATAT ACAGATAGAT TTTGGAGGCA

31501 TTAGCTTAGT GATGATTCAG GAGTATCCAT TATTTGGGGA AGTAGGTGGT CATTAGTGAC

31561 CTTTTACAGG CATTTCAATG GGCTAACAGA GATGTTAGAT TGTAGTGGAA TAGAAGAATG

31621 GGTAAAAAGT AAATCAGTGA GTTCAGATTT TAGGAGTTAA GATGGCAAGA GGTGAGAACA

31681 AAAAAAGGAA ATGATTGTCA TTAAAGGAGG AGGAAAGACC AGCCAAAGAT TTTACAGTGA

31741 GTTAAGCATA CAAATTTATT TCTAGGCCAC ATATTCTTAG CAAAACAACA TGTAAATGTT

31801 TATGTATGTC TTTCCTCATA TCTGCTCATC CATCAGCTCC ATCGTTAAGA TTTCAGTTTT

31861 CCAGGACAAA CTTACTCACT TTGACATATT GGACTAGGAT TTGACCAGAT TCCAGATGAT

31921 TCACAAATGG TTTTCTTCTT CCCAATTAAC TCAGTTCCTT CTGAGCAGAT GAAGGTACAT

31981 GCAGAGGTAA AGCTGAAGCT GGCCAGGGGA TGGCTACAGT TCATGATCCC CAAATCTGGT

32041 GCTGATAGAG GCTCACACTG AATCACTTCA ATGAAAAAGA AAAAAAAAAA AAAGACAAAA

32101 CAGTATTTCT GAGTAGAGAC CCTCCCTTGA GCAAAGGATT TTTAGCCAAA GCTGCCTGAC

32161 TACATTACTT GTGATATTGC TTCCAGGCTT TATTTTCTTG AGAATGATGG TGGGTGGTGA

32221 ATGAGAGATG AAGGCAAGGA AGCATTGAAA GCTGTGGGGA GAGGAGTAGC TACTCCAGGC

32281 TGCTGCCCTA GCTAAGGTGA CCCTCCCCTT CTGCTGGAAG TACCATGCCA TATGGCCTCT

32341 GCATCAAGGG CTCTTATGGG ATATTCTCAG AGAATCTCTG CCGTTTCATC TGTTCTGATA

32401 TCTACCCAAG CATTTTGAAA AACATCCCAA TTCACTGAAG CAAGTCCAAC TTCCGTAAAT

32461 TCCAGTAGGT GGGTTGACAG TTTTATAATT TCAATAAGGG ATTTTGATAG CACTTCTAAG

32521 AATTAAACTA CTTAAACTAA TGCATCAGGA GCATACTTGT AGAAAAGTTA ACCAAAACTT

32581 CGTAAGTTCA GATGACATTG GTTTTCTCCC ATATGGAGAT AAGGTTGGCA GTTAAAAATG

32641 AAAAAAAAAA AAAAACCTAC CTTATTTCAA ACTTGAAAAG ATCAAGAGAT TGTGTTTTTG

32701 TTTTTCAGTT GTTATTCTCC TAAAAGTTTA TGCATGAGGA AAAGTAAAAG TGATTTTAAG

32761 AATAAGCCAA ATAAAACAAC CAAGAAAGAC CTCCACTACC CTGGGAAGGA AACTGGTTGG

32821 TATTAAGTAG GACACCACAT AAAACAGGTG TTATTGAGAG GAGAAGAACC AAAATGTAAC

32881 TGAGGTTCAA CAAGACATTA TTTATGCAAT GGCAATGAGA AAAATAAAAA ACACAGTATA

32941 ACCATGCTGT ATTGCTATAA GTCATGTTAC ACACTGGGAG ATGGCTTCAG GGGTATTTGG

33001 TTTTTACTTT TTGTTTGGGA GGTTTTTCAA AAAAATTTAG TTAGAATAAG TCCTTTGAGA

33061 AACATCACAG TAGGTTAAAC AAAGTTAGGT TAAATTAGGC TCCTAAGTTT GACTTCTCAG EPI-109 621

33121 CAAACTTCTA CTGAATGTTC TGACTGTAAG CCCAGGATTG CATGACAAAA CCTCTAGTCT 33181 GAAGTTACTC ACCTTGACAG GTTGGTTCTG GAGATGACCA GTTTCCAAAT GGTCCACAGG 33241 TGGTTTCTTC AATCCCAGTT AAGTTTGTTC CTTCAGAGCA GCTGAAGGCA CACTGTGAGC 33301 TGAAGCTGAA GTTTCCCAAA GGGTGAGTAC AGTCCATGGT ACCCAGCTCT GGGGCCTCCA 33361 AAGGCTCACA CTGAATCACT TCAATAGGGA AAGAAACAGT ATGGGGAAGA GTTAAGAGGA 33421 ACTGACGCCT GGATTTGAAT CCTAGCCCTG CCACTTGATA ACCATGTGCC TTTAAACAAG 33481 GTTACTTGAA CCCTCCAACT TCAGTTTCTT CATCTATATA AGAGGAATAA TGAAATTGTG 33541 TTATCTTTAT CAAATTGATA TGGAAACTAA ATGTAATTCA ATTAGCATAA GTCAAGGACC 33601 TTAGAACAAA GCCTGACTCA TCAGAAATTC TAAGTAAACA TTAGCTAGTC TTCATATTAT 33661 TATCTTCAGC ATTATCTGTA GTGAGAATCC TTAAAGCCAA ATAGGTGTAA CTGGGAATGA 33721 CCAGCTTAGT CGGGAAATAA CTATCACATC AGAGCCCCTG AGTCTACTAG AGTATTGGGA 33781 GCAAGATGTT CAGAGAAAGA GTGGGTCTCC ATAATAAGCC TTCTTTGCAA GGAGAGAATA 33841 TAAAAGTCTA GGAAGCATTT TGACCTCAAT TCTGTCTTCT ATTCTAGCTC AGTTCCAGAA 33901 TTTTAACTCT TTTGATTTTG ACAACCCTCT CCAGAAACTG TATCTATTTC CCTGTTCTGA 33961 TTGGTGGTAC AATAGGTAAA TTTAAGACTT GGAAATCAAA GTTTTCACAT TTTAGACCCT 34021 GCCATGCCAT TTAGTAAACA GTACAACTTT CATGTCTTAT TCCTCATCTG TCAAATTTAA 34081 GCCATTATTG CTACCTTGCT CTAGAGACTT CAAGGAAGAA TGGACTCAAG GAATCAGAAG 34141 AATTTTTGTA TTTGGAAACT ATATGAGATG AGATTAGGGA GAAACATGGG AACTAAGAGA 34201 AAATGTTATC TTTTTTCATT GATTTAAAGA GTATCTATTA TATATCAAGC ATTACTCTGG 34261 GGCTTGAAGA GCTTAGATTT CACCCTGTAG GACAAAATGG TAGGTAGAAA TTAATGGGTG 34321 GATTGTCATG TATGTGTGAT GTGTTTTAAT TGCTTTTAAT TGATCAGTCT CCCTGTAGTA 34381 TGAATAATGT ATTTGAGGGG AGCTAATTTA AAATTGTGGA ACTCATCTAA TAAACTATTG 34441 CAAGAATCTA GAAGAAAGAT AATGACGGCA ATGGTAGTAG AGTTGACAAG TGGAAGACAA 34501 ATTAGAAAAA CACTAAGTTG TAAAAATTGG TAGAATGTTA CCCTGCATAA ATGTTGGGGG 34561 AGTTAAGAGA GTCTCATACC AGGGTGCCCA TGTAAATGGT GATTCCACAT ACTGAGATAA 34621 GAAATACGAA GAGAAAAGCT GACTGGGAAC AATTGGTTTT ATAGTCTTTT AAACATCCCA 34681 AAGGACATCC TTAGCATATT TGAGTTCAGA GCTGGAGATA GGCTTATCAG TCCAAAGATC 34741 ACATAGATTT GTGAGTCCGC AAAAGTCAGT AAGTTTGACC AAAGGATACA TGTAGATTAG 34801 AGTCAGAAGA GCAATATACA AAAGACAAAA GCTGAGAAAT TATAGTAGTT TATGGTCCTG 34861 GATAAGTGCT CATGAAGGAT CTCAGGAGAA ATGATCACAG GTAGAAAGAA TGAGAAAAGA 34921 GTGATATGAG AGAAACCAAG ACAAAGAAAA GTAAAATGTT AAAAATGAGT GAAATAGGCA 34981 TACCAATAAT TAAAAATGAG TAAAATAGGC ATACCAATAA CATAAGGGTT AAAAAATAGA 35041 GTTCAAAAAT GGGGTGAGGG TAAAGTATTA GGAAGGAGTC ATGGCCCAGG GATCAAGTGA 35101 AATGAGTTAG ATCTATAGAT CTATTTCAGT TGGTTGACAT TTAAATGTAT TTTGGTTTTA 35161 ATTCTTTATT GTTTACAAAC ATTGCTTTTT TAAAAAATTA AATTGTCCAA TTCAATTCAG 35221 GCTCACAAGC AAGTGCCTCA TATATACAGG CATTTTGTGG ATCCCAAAGA TGCAATGATA 35281 AATAGGACAC TTACTGATCT CAAGAAGTTT TCAGTACCAG AGGAGACGGA CAAGTGAACA 35341 GATGACTTCA ACATAAGTGG GAGAAATGAG GAAGAAATAT GTGGAGCTAT CAGAACTAAG 35401 AAAGCTTCCT AGAAGAAACT GTCTTTGAAC AATGTCTTAA AGATGACATG TTTTTTGGCC 35461 ATGTGCAAAA TGAGAGAGAA GGCCACCAGC AAAGTCAGTG TGCTACAGAG CACATGTGTT 35521 AAGTGTGGAG AACTGCAAGA AGGAAAGGAA CTACTAGAAG GAAAAAGCAA GATACTTTCT 35581 GGGTAACTCA GCCTCCTAAT GATAAATGGC ATAGTTTCTT CCAGACCTTA GAGTTCTAAT 35641 TAATCTAACA AGCTCATTAG ATCGTGAGCT TCTTGAGAGC GGGAATCTAC CATGCTAATT 35701 CCTTATGGTA ACCCTGACAG CTTTTATCCC AACACTGTGC TTCTTGTGGT ACTCAAAAAG 35761 ACTTGTTGAG AAGTGAGTCG AAACTTCATG CTGACTTATG AAATCTTTAC GGAAAGGTAA 35821 CAATATTGTG AAAGCAGAGC TTTCTGATCA AAACTTCCCA TTTCTCAGAG TGGCTAGTAT 35881 CATTTTGTTC CAACCAGCTT CATGATAAGC TATAATGATT CCTGTGACTT TACCTAAGAA 35941 GAAGCAAAGA AAGGAAAGAG ACTTACCAAA CTGACACTGG GGCCCATAGT ACCCCACATC 36001 ACAGTTGCAG GTGTAATTAT TGATGATTTC TACACATTCT CCATGGCCAC TGCATGACCA 36061 GGGCTGGCAA GAAGCTTTAA GGAGGTCAGA AAAAAAATAT TTTAATGTGA TTACATTTTA 36121 GTACTCAAAG TCATTTCTTT AGACATAGAT AACCTTTTGT CTGAGATGAT TTAAATAATC 36181 AGGAAAGGTT TATTTGTAAA TTCATAGCAT AAAAATCATA TGCTAAAATT TTTACGTATA 36241 AAATACACTA AGCATATAGT CATAGGCATT TATTTGCTTT TGGAATGAAA TTACCAATAC 36301 TAATATTCTG TAACACTTAT AGGAAACTTA GTGGCATACC TTGAAACTCT TGAAATTACT 36361 TGTTTTTAAT GAGTGAGAAG GTTAAATGAT GACCTGACCT CAATCATTTC TGCATGCAAT 36421 TATTTCTTGG CAATCCCTTT CTTTATAGAA ATCAAAGATT AAAAAGTCCA AATTTGCTAA 36481 AACGGTAGAG TCCAATTTAT AAGAGACCAA ATTAACTATG GTTCATTATT AAAACATCAC 36541 TTGGAAAATG CTGGCTGTTT TGGAATTGTA GAAGATTTTA CAGAAATATT CATACACCAA 36601 AGATAGTGCA ATTTTTATAT AAAATTATAT AAGGTTAGAC CAAGAAGGAA GCACGCAGCA 36661 CCACACTCTC TACTTCACAA TGTGAAAACT GAGGTGATGT GAGCCTAAGT TTCCAACTGG 36721 CCCCAGCTGT CAGCTTCTCC TCCCCTGCCT TATTATCAAA GGCACTGATT GTCTAGCTCT 36781 TCCTCTGTAC TTCCTACGTA GATCTATCAT TTTGATGTAA CTTGATTTAG GGGTATAGCT 36841 TTTGTGCACA GGGACAAATC TTACACACCA AAAATTCTTA GGAGTGACAC GATGCAAGAT 36901 TATATAGAGG GCTAGATGTA TTTTAGAATG AACCAGAAGC TGTTCTCATC CCCCCACCTT 36961 TCCATGGGGT AAATCTGAGT ATTCTCTTAA CCGTGGCCCT TCCTGAGTCT GAGGCAGCAT 37021 AGCCGTCTTG TCACTCCCTA CCTGTGTAAC AGAGGGCTGC CTTTAGTTTG TGGCAGGCGT 37081 CATCGTTCCA TTTGCCTGCA TCTTTGTTTC TCTTGATATA GATCTCCACG CAGTCCTCCT 37141 TGTTCTTCTT GTTGTTGGGC TCACCATCTC CCCAGTTCTC TGCTTCTTCA GTAAGAGATT 37201 TGTTGGTTCC CACCCACGTC CATATTCCTC CTATCTTCCG GATTCCTATC CAGTAGTAAG 37261 AACGACTGAA AGGCAGAGTC TTCTCCAGAT ACTCAATTTC CGCCTTGTTT TGTATGGCAA 37321 CTAAATCTGT GTAATTGTCT CGGCAGAATC TTCTAGCCCT TTGCCAGTTC ATGGGTTTTT 37381 CAGAATAATG GTAAGTCCAG CAGTCGGTTC CATGATGTGC CAGGAAATCT GCAAGACATC 37441 AGTGTGACCT ATGCAGACTT ACATAATGTT ACAGCTAAAA AGAACCTAGC ACTACTCCAG 37501 GCTGAGCTAG ACACTTAGAG ATGAGGAAAC AGAGCCTAAG AGTGTATGTG ACCATCTCAG 37561 GATCACAGAA TAGTTGTTTG CAGATTTGAA GTAGAACCTA GACCTTCTGG CTTGAATATA EPI-109 622

37621 AGATGCTTTT ATCTAAGGTT CTATTTGAAA CAAATTTAGT GGTTTTCTAG GTTTATTTTC

37681 TTATTAATTT TTTTCTCAAA ATTATTTCAG GTGAAATTTA ACCAACATAT TTTAGACATT

37741 CATATTTCTT TTTCTTTGTA GCTGTTAATG ATTTACAACT AATTACCGTG TAATATCATA

37801 TAACTATACA ATTTACGTAT ACTTTTTAAT CCTGGAATCA TTTCTTGAAG GCCAACACAT

37861 ATGTACCTAT GGGAGAAGCA TAATAAGGAC AGGAAGAACA GTGACATACT TTTAAGTAAC

37921 CTCTTTTACA TAAAAAACAT TTTATTTTAC CATAGGAAGA ACTGCTTCTG GAAAAGCCCA

37981 ATATACCACT CAACTCTTAT ATATCTAACT GTATAATTTT TAAAAAGAAC AATTTACAAA

38041 GCCAAATGGT ATAGGATTAT GAAATTCATT AGATCATGTT CTATACACAA AGAGACTCAA

38101 CTGATGATGT TTAATAAACA TATGGACCCA TCAAATATGA GGGCTTTGAA GATATCTAAT

38161 TAAACACATA ATTACACAAT GACTTCATAA TAATATATGG CATTCTAAGC ATGGTATGAT

38221 CTACATGAAT CACTATTTAA TACAGTAAAG AAACAGATAT AATTGATGGT AAAGAGCATC

38281 ATAAAATAAA CATTTTGAAC AGAGTTTTGA ATGAGCATTC CACTAGAATG CAAGTTCTAA

38341 GAGGGAAAAA ACTGTTGTGT CCACTGCTGT ATCCTTAGTG CCTAGCATAA ATTTCACACA

38401 TTGTAGGGAC TCAGAAAATA CCTGTTGTAT GAAAAGAGCA CTAAGTTTCT ATGTGACACA

38461 GTGCAGACAT GGCATAAGGA ATGTGTGAAC GGGAGAGTTA GCATGTTTGC TTGGCTAGAG

38521 CTGAAAATCC AGGCTAGGGA GAAAGAAGAC ATTAGTTTAC TTAGGAAATG AAAAACCAAG

38581 TTCAAAGCTA TTGCTGGAGA GTCTTCAAGA ATCAGATATA AAATTTGTCA CAACAATGGG

38641 AGAAGGACCA AAAAATGATA AACCCCCGTC CCTTAATAAG CTCGTATTGT AATTGTAGAA

38701 ATGACATTAA TGTACACTGA ACTATGAATA AAAAATAGAA AATGAGGTGC TAAATATTTG

38761 GTACAGATTG TAAGTACCTT AACAGAGATT TCTTAATTAA CATTATTCCT TTATAATTGA

38821 GGGATTTTGT GGGGTTATTG GGATTTGAAC TCTACAGCAT GGGCTATTAT AGGTTAAAAA

38881 TAGTGTTCAG GAGTTTCTGG GGAAGAACTA AAGGTAAGAA GAAAAGAGAT GTTTACAGAA

38941 GGGATAGAAT TAACAGCTCT GTGAAATAAT TTTCCCTTAG ACTATGTATA ACTAGTGGAT

39001 ATTTAAGAAA AATGAATATA AGTAAAATAG ACTTAGCGAT ATATAAATAT CATAACATAC

39061 CACAACAGAG CATTGTCCAC CCCCACAACT TGAAGATGTT CCATAAGTCC CTCTGGGTGC

39121 TCTGACATTT CCATGGAAAT ATCTGCAAAT GAAATACAAA ATTATATTTA GATGTATACT

39181 CTTAAACCAC ACATTTATAG CCTTTGAGGT GGTGCTTACA ACTTTCTTAA TAATCAGAAT

39241 AAAACACATA TGTCTACTAA CCCTGTCTGA GGTAACAGGT TTCTCAGACA TAGATGAAAA

39301 ATTACTTCAA ATTTACATCA GAACTGATGC ACAGTTTTGT TTTGTTCTAT TTTATTTTTA

39361 CGCTTTAGTC TCAAGTTGCT AATCGGTACT GCCCTGAATT TTTTCTATGG TTTGGTAATT

39421 TTTATACCTG CTTTTCTGCT GAGCTATTAG ATAAAACTAT TTAATATTTA CTATGTATAT

39481 TTTTTAAAGT ATTGTTGCTG CTTAATTAAC TATTGATGCT TATATTTAAT GTTATAGCCT

39541 CACTCTTGAT CATAATGGGT CAATGCCTCA AATACCTAAA AAAAAAAAAA ATTAGATAGC

39601 CAGACACCAG GAAAGAAAAG TATTTCTTTT TTTAATAAAA AGAAATACCT TTTTGAGCAA

39661 CTGAAATGAC AAAGTCACAA ATTTCCTGCA CACCTTAAAA TATACTTAAT GTAAATGACG

39721 AGTTAATGGG TGCAGCACAC CAACATGGCA CATGTATACA TGTGTGACAA ACCTGTATGT

39781 TGTGCACATG TACCCTAGAA CTTAAAGTAT AATTTTAAAA AAATTCTATC TTCCAAAGCA

39841 TATCACTTCT CAGGTAGACA CAGTGTTTAT TGCAAAAGAT CTGATTTCAA TAGTATTTCT

39901 TCAAGAGTCT CCCCAGAGAC AAAGTCAAGA AGAGGAAATC AGCATATCTG AGAAGAAAGA

39961 TTTCAGGATC ACTTTTTTTG AGGGTCTGAG AAAATGTTTA GTTTCTATAT TATTTAAAAC

40021 CAGAATTGAA ATGGGGTGAT TCCTATCCTT GCCACCTGCC TCTACAACCC CAAGAGTTTC

40081 TATCTGAGCA TCTAAACGTC TTTTAGGCTG AAAGGCTCAC CATGGCTTTG CTTGGTCCTT

40141 CTCTAGTTCT TCTGCAGCCC ATTGAGCCTC TTGACTTAGC ACAAGGGTCT CAGGTCCTTG

40201 CCCAAAGGGA GTGTGCTGTG CTGCAGGTAG ACTGCACTGA ATGTCAACAG AAAGCCTTGC

40261 TTTCTTTCAT TTCTCTAACC CAGTCTCACA TCCTCCTCCT CCTCCCCTTT TCCCTCCCCT

40321 TCCTCCTGCA CTTCTCTTTC CTCTTTCCCC ACCCCTTTCC TAGACTGGCC TCTATTGCCT

40381 CCCACTGAGA CAAAAATGAA CTGCTGATCA GAAAGTAATG TGACTAGATT CTCTCTTCCT

40441 TCCCTCCTTT CTATCCTTCC TTCCATTCTC CTATGCATCT TTCCTTACCC TCCTCCTCCT

40501 TCACTCATTG TTGTTGCTGT TCTTCTTCCT CTTCTTTTTC CTCCTGCTCC TCTTCTTCTA

40561 CTTGTTCTTG TTCTTGTTTT TGTTTGGTTC TTGTTCTCCT CTTCCTCCTT CTCTCTCTCC

40621 TCCTCCTCCT TCTTTTCCAC CACCCTCCCC TATCTTTTTC ATAAATGCTA AACTAACTCT

40681 TGGCTACCTG TGGTAAATGG CCCTTGGAAA TTGCAAATAC TACAAATCAA AACTGCATTT

40741 CAGACATATT TATGATGTTT GCAAAACTTC AGTAGAGCTA AGCAGTGGAC TTGACTCGTT

40801 TCGGTTCCTT CACCTCCGTC TTTCCTTGCT CACCACCTAG TGGACGTCCT TGTTAGTGGC

40861 ACTTCCTGAA GTTAACCCCT GAAGAGAGCC CATGCTCTCT AGCTTTTCAC CGTGTAGGTT

40921 TGGGAGCCTA CAAGTACCTT TAATATTCTT GGACTATAAA ATGAGATGGT TTTATAAGAC

40981 TGCATGTGAA ATTAGGACCC ATATGATGAA GGACAATAAA AAGGAAGACC CACTGATGTG

41041 AGTCAATGAG TCAAATGCAA ATCAGATTTG CATTTTTAGG AAAATAATAA TAACAACAAC

41101 AAAAACTCTG AAGCTCAGCG CCCCATATTT ATTATATTGT TTAATCTTTA TAACAGCTCT

41161 CTGCTATAGA TATGATTATT ATCCCCATTC TAAAGAGTCT CAAAGAGGTT AAGAAACAAA

41221 TTCAAAAACT AGCGAAAGAC AAGAAATAAC TAAGATCAGA GCAGAACCAT AGGAGGTAGA

41281 GACACGAAAA AGCCTTCAAA AAATCAATAA ATCCAGGAGC TGCATTTTGA AAAGATTAAC

41341 AAAATAGATG GACCACTAGC TAGACTAATA AGAAAGAAGA ATCAATAGAC ACAATAAAAA

41401 ATGGTAAAGG GGATATTACC ACTGATCCCG TAGAAATACA AACTACCATC AGAGATTACT

41461 ATAAACATCT TTACACAAAT AAACTAGAAA ATCTAGAAGA AATGGATAAA TTCCTGGACA

41521 CATACACCCT CCCAAGACTA AACCAGGAAG AAGTCAAATC CCTGAATAGA CTAATAACAA

41581 GTTCTGAAAT TAAGGCAGCA ATTAATAGCC TACCAACTAA AAAAAGCCCA GGACCAGATG

41641 GATTCACAGC CAAATTCTAC CAGAGGTACA AAGAGGTGCT GGTACCATTC CTTCTGAAAC

41701 TATTCCAGAG AATAGAAAAA GAGGAACTCC TCCCTCACTC ATTTTATGAG GCCAGCATCA

41761 TCCTGATACT AAAACCTGGC AGAGACACAA CAAAAAAAGA AAATTTCAGG CCAATATCCC

41821 TGATGAACAT CATTGCGAAA ATACTCAATA AAATACGGCA AACTGAATCC AGCAGCACAT

41881 CAAAAAGCTT ATCAACCACA ATCAAGTTGG CTTCATCCCT GGAATGCAAG GCTGGTTCAA

41941 CATACACAAA TCAATAAACA GAATCCATTA CGTAAACAGA ACCAATCACA AAAACCACGT

42001 GATTATCTCA ATAGATGCAG AAAAGGCCTT GGATAAAATT CAACACCCCT TCATGCTAAA

42061 AACTCTCAAT AAACTAGGTA TTGATGGAAC GTATCTCAAA ATAATAAGAG CTATTTATGA EPI-109 623

42121 CAAACCCACA GCCAATAGCA TACTGAATGG GCAAAAACTG AAAGCGTTCC CTTTAAAAAC 42181 TGGCACAAGA CAAGTATGCC TCTCTCACCA CTCCTGTTCA ACATAGTATT GGAAGTTCTG 42241 GCCAGGGCAA TCAGGCAAGA GAAAGAAATA AAGTGTATTC AAATAGAAGA GAGGAAGTCA 42301 AATTGTGTCT GTTTGCAGAT GACATGATTG TATATTTAGA AAATCCCATT GTCTCAGCCC 42361 AAAATCTCCT TAAACTGATC AGCAACTTCA GCAAAGTCTC AGGTTACAAA ATCAATGTGA 42421 AAAAATCACA AGAATTCCTA TACAGCAATA ATAGACAAAC AGAGAGCCAA ATCATGAGTG 42481 AACTCCCATT CACGATTGCT ACAAAGAGAA TAAAATACCT AGGAATCCAA CTTACAAGGA 42541 ATGTGAAGGA CCTATTCAAG GAGAACTACA AACCACTGCT CAAGGAAATA AGAGAGGACA 42601 CAAATGAATG GAAAAACATT CCATGCTCAT GGGTAGGAAG AATCAATATC ATGAAAATGA 42661 CCATACTGCC CAAGGTAATT TATAGATTCA GTGCTATCCC CATCAAGCTA CTACTGACTT 42721 TTTTCACAGA ATTAGAAAAA AACTACTTTA AATTTCATAT GGAACCAAAA AAGAGCTTGT 42781 ATAGCCAAGA CAATCCTAAG CAAAAAGAAC AAAGCTGGAG GCATCATGCT ACCTGACTTC 42841 AAACTATACT ACAAGGCTAT AGTAACCAAA ACAGCATGGT GCTGGTACAA AAACAGATAT 42901 ATGGACCAAC GGAACAGAAC AGAGGCATCA GAAATAACAC CACACATCTA CAACCATCTG 42961 ATCTTTGACA AAGCTGACAA AAAGAAGCAA TTGGGAAAGG ATTCCCCATT TAATAAATGA 43021 TGTTGGGAAA ACTGGCTAGC CATATGCAGA AAACTGAAAC TGGATCCCTT CCTTACACCT 43081 TATATAAAAA TTAACTCAAG ATGGATTAAA GACTTAAATG GAAGACCTAA AACCATAAAA 43141 ATTCTAGGAG AAAACCTAGG CAATACCATT CAGGACGTAG GTATGGGCAA AGACTTCATG 43201 ACTAAAACAC CAAAAGCAAC AGCAACAAAA GCCAAAATTG ACAAATGGGA TCTAATTAAA 43261 CTAAAGAGCT TCTGCACAGT AGAAAAAAAA AAACTATCAT CAAAGTGAAC AGGAAACCTA 43321 CAGAATGGGA GAAAATTTTT GCAATCTATT CACCTGACAA AGGGCTAATA TCCAAAATCT 3381 ACAAGAAACT TAAACAAATT TACAAGAAAA AACAAACAAC ACCATCAAAA AGTGAGTGAA 43441 GGATATGAAC AGATGCTTCT CAAAAGAAGA AGTTTATGCA GTCAACAAAC ATATGAAAAA 43501 AAGCTCATCA TCACTGGTCA TTAGAGAAAT GCAAATCAAA ACCACAATGA GATGCCATCT 43561 CATGCCAGTT AGAATGGCGA TTATTAAAAA GTCAGGAAAC AACAGATGCT GGAGAGGATG 43621 TGGAGAAATA AGAATGCTTT TTACAGTGTT GGTGGAAGTG TAAATTAGTT CAATCATTGT 43681 GGAAGACAAT GTGGCGATTT CTCAAGGATC TATAACTAGA AAAACCATTT GACCCAGCAA 43741 TCCCATTACT GGGTATATAC CCAAAGGATT ATAAATCATT CTACGATAAA GACACATGCA 43801 CACTTATGTT TATTGAGGCA CTATTCACAA CAGCAAAGAG TTGGAACCAA CCCAAATGCC 43861 CACCAATGAT AAACTGGATA AAGATGATGT GGCACATATA CATCATGGAA TACTATACAG 43921 CCATAAAAAA GGATGAGTTC ATGTCCTTTG CAGGGACATG GATGAAGCTG GAAACCGTCA 43981 TTCTCAGCAA ACTAACACTG GAACAGAAAA CCAAACATTA CCCATTCTCA CTCATAAGTG 44041 GGAGTTGAAC AATGAGAACA CATGGACACA GGGAGGGGAA CATCACACAC TGGGGCATGT 44101 CAGGGGATGT GGGGCTAGGG GAGGAACAGC ATTAGGAGAA ATACCTAATG TAGATGACAG 44161 GTTGATGAAT GCAGCAAACC ACCATGGCAC ATGTATACCT ATGTAACAAA CCTGCACGTT 44221 CTGCTCATGT ATCCCAGAAA TTAAAGTATA ATTTAAAAAA AGTTTAAAAA AAGAAAGTTG 44281 CCTTAGTCAC ATAACTAGTA AGAGACATGG TTGGGAATTT GAACAGAGGC CAATCAGTTC 44341 CAAATCCATG CTCTTGATCA TTAAGCTGAA CTTATGGCAG GAACTTGGAA GACATGGTAA 44401 AATGGGGAAA AACGTGGAGC CAGGGAGACT TGTGAAAGTG CCAGTGCTCC CACTATACCC 44461 TGAAAGAAGT ATCTAGACTT ACTTTTTTCT AAGTCCTCTC CTCTAATTCT CTCAATCTCT 44521 CTCTCTCTTT CTCTAAGAGA TGGGAATGCT GCTCTGTCAC TCAGGCTAGA GTGCAGTGGT 44581 GCGATCATAG CTCATTGCAC TCAAGGAATC CTAGGGTCTA GTGCCCCTTC TCCCTCAGCC 44641 TCCCATGTAG CTAAGACTAC AGGCACATGC CCCAACCCTC GACTAATTTT TTTATTTTTT 44701 ATTTTTGTAG AGACAGGATC TCACTATGTT GCTCAGGCTG TAATTCTGTC TTGAAGCTTG 44761 TCCAATCAGG CTTTCAGCCA CACCAATTCC CTGAGACTGC TCTCACCAAG GTCCTACACT 44821 TCACTAACAC AAACAGCCTA TTCTCCATCC TCATCTTACT TCACCAGGGA GCTCCTGGTT 44881 TTCCTCCTAC TTCACTGGCT ATTTCTTCTG TATCATGTGT TGATTCTCCC TCATCTCCCC 44941 AACCTCCAAA CCCTTGGAGT ACTCCAGAGA TCACCGCTTT GCTCTTCTGT GTCTAACCTC 45001 ACTAACTTGG TGGTCCAATT CACACTCTTG ACTTTGAATA CCATTTAAAT GCGAACGAAT 45061 TCTAAATTCT GTACAACCAG AACCATTCTC CTGTAGCCAA ATGCCTACTC AACATCTCCA 45121 TCCCCAAACA AATTTAGTTG TTCAATAAGC CTCTCATATT TTACATATCC CAAACTGAAC 45181 TTCTGAATTT CTCCTCCAAT CTGTAGGGCT CTTCCCACAG CCTTTCCATC TCAGTGGATT 45241 ATAACTCCAT CCTTCCAGTT ACTCAGACCA AAACTTTTGG AGTTAACTGA GACACCTCTC 45301 TTTTTTTTCA CAAGTCATAT CCAATGTGTC AACAAATTTT GGTAGTGGAA ATATTGCGGG 45361 ATTTTTTAAG AAATCAGAGA GACCGATGGG GTTCAGGAGG ATATTTATTA TTTAGGTGCA 45421 CTGGCCAAGT CAGATTAACA TCCAAAGGAC TGAGCCCTGA ACAAAGAGTT AAGTTACCTT 45481 TTAAGCATTT TGTGGGGTGG GAGAGAGGGG TATCTGTGCA GGGGGAAGCA TACTACAGAA 45541 GTGAGAAATA AAGACAGTTA TTCAATTAAT TGAGACATGC ATTACATCAT TTCTTACTTT 45601 TCAAGAAGAA ACATGTTTTG CGACTTGAGT TTATCTGTCT AGTGACCTTG CAGCTGCACA 45661 GCTAGAGAAA CAGGGTCTTC ACAATGCCTG GGAAAGGAGG AGAGGTAAGT CTCACTAGCC 45721 ACAGAAAAAC AGGCAGTTAA TTTTTAAAGG GCTCCAGCTC TTTCTCTTTC TCAGGGGGAG 45781 TTGGGTTTTG TTACATACAA CTGAGTTTCC GCTTACACAT TATTTAATTT CTTTTAATTC 45841 CTGTTCCAAA AGAAGCCAGA TACAAAAGGT TACATGTTGT CTGATTCCAT TTATATGAAA 45901 CATATAGAAG AGGTAAATCC ATAGAGACAG AAAGTAGATT AGAGGTTCCC AGGGGCTGAG 45961 GAAGAAATGG GGACTAACTG CTTATAGGGT ACAGAGTTTT CTTCTGATAA AAATATTTTG 46021 GAACTAGATA GACATTTTGT TAGGCCATTC TTGCATTGTT ATAAAGAATT ACCTGAGACT 46081 TGGTAATTTA TAAAGAAAAG ATGTTTAATT GGCTTACACT TCTGCAAGCT TTACAGGAAG 46141 CATGGTGCCG ATATCTGCTC AGCTTCTGGT AAGGCCTCAG GAAGCTTACA ATCATGGCAG 46201 AAGGTGAAAG GGGAGCAGGC ATATCACATA GCAAAAGCAG GAGCAAGAGA GGGATGTGGG 46261 GAGGTGACAG TCACTTTTAA ACAGCCAGAT CTTGTGAGAA CTCATTCACT ATCATGAAGA 46321 CAGTACCAAG AGGATGGTAC TAAATCATTC ATGAGAAACC CCACCCTCAT GATCAAATCA 46381 CCTCCCACCA GGCCCCACCT CCAACACTGG GGATTACAAT TTGACATGAG ATTTGAGTGA 46441 GAACACGGAT CCAAACCATA TCAGAGATGG TGGTTATACA ATGCGATAAA CGTCACTGGA 46501 TTGTACACTT TAAGATGGTT GTTTTATGTT GTGTGAACTT CACCTCAATA AAAAAAAATA 46561 TTTAATGTAC ATTCAGCCAA AAGAAGATTT GGAATAGGAA AGGTCATGGA GATATATTAA EPI-109 624

46621 CAGCCATTTG ATGGGTGGTA AGGAAAAGAG TGGTTATTAG ACTGTTTTGT GGCCCTCAAA

46681 AGGTAGAACT AGATCGAGTT GGTGAGCATT ATAAAACCAT CACAAAACCC TGGAGAGAGG

46741 ACCCAGTGCT GAAGAACCGT TTGCCTGCCA TGAGACATGA GGGAAGTACC AGTGAATGCC

46801 ATTGAAAGCA GCATCCCTGG GTCCAAGGGA TGGTCAAAGG ACCACTACCC AACCCTTCCC

46861 TAGCCTACGC CTCCATTACA GATGACCGCA AGATTTATTT GCTCATTGCT GCCAACCAAG

46921 GCTGCACTCA CTGCAGTTGC TATCAGTTTA TCATGGGTAA AAGGAATGTG CAGTAGAGAA

46981 CTAACTAACT GCCCACCTAC CTCCACAATC CTATCAGGAC AAATCACCAT GGCTCACATT

47041 TCCTTACATT TGGCATGTAA GCCCCTCTTA CTGTCTGTCA TCTATCTCCT ACACAGTTCA

47101 CCTAAACTGT TCTCTCCTGA CCCAACCTTG ATTTTCATCC CAAATGCTTC CTTGCCATCT

47161 CTGGGATTCC TGTCTTCACC ATCACCAAAC TCCCCTCAAT CTTCCAGTTT CCTGTTCAAA

47221 CTTTTCTCCT ACCTCCTTGC TTTGTCATTA GCCCGACTGC CTCCCTAGGA CATCACTTCC

47281 CCTGCAGATC TCTCAAGATG ACAATATTTA TTCTCCACAC AGCACATACT TCAGGGTTGG

47341 AAGGCAGGGG CAATCTTCTC CTTTATAATG AGTGCCTCTT ATATATGTTT ATTCATCTGC

47401 CCTCTTGTAA AACACACACA CACACACACA CAAAGAAGAA ATAAAATAAC TCTGCTTCTT

47461 TGAAGCTTGT GACACTGAGA TAAACCATCT CACTGTCCTC ATTGTAGTGA CCTCTCAACT

47521 CCTCATGCAA GATTGGCTTT GGCACCTAGT TCCTGATCTT CCTTTCCCTG TAAGCACTTC

47581 TCATAGTCTT ACGGGACTTC ACCATCCATG GCACAACCAA TACCACAGCC CAGATCCTCA

47641 GCTCTCCAAT GACATTTTCC TCCACTAGAC TTGAGCTACC TCCTTCCCTA GGCACAGCCT

47701 CAACCTCGAC AACACCTAAG ACTGTACCGT CTCTAAAGTC ACATGTTCAA ACACTTCACT

47761 CTTTAACCAC TGTCTCCTAT TCTTGCAAGT GTATTGCTCA AGTATCTCAT TGCAATGCTT

47821 TTTACTTCTA CCTCATTGAA CCTCCAGGCC ATTAAACATT TCCTTATTTC TAACCATCAG

47881 GTTTCTCCTT ACTTGTTTGT TTGTTTATTT GTTTCTTTTT TTTGAGACAG

47941 GGTCTCACTC TGTTGCCCAG GCTGGAGTGC AGTGGTATGA TCTCGGCTCA CTGCAGCCTC

48001 CATCTCCCTG GTTCAAGTGA TTCTCATGTC TCAGCCTCCC GAGTAGCTGG GACTACAGGT

48061 GCATGCCACT ACGCCTGGCT AAGATTTTGT ATTTTTATTA GAGAAGGGGT TTTGCCATGT

48121 TGGCCAAGCT GGTCTCGAAC TCCTAACCTC AGGTGATCCA CCTGCCTCAG CCTCCCAAAG

48181 TGCTGAGATT ATAGGCATGA GCCACTATGC CCCACCTGGT TTCTCCTTAT TTATTTCAAG

48241 TCTATGCTGC ACTATTAAAA CTGCCTTGAC AAAAATTATA ATAGTGAGAA AATTATGACA

48301 GTGAAAGAGA TCTGAAATAA TCAACCCCCA TCTTGCCTTT ACCTTCCAGA CTGCCCTTAA

48361 TAATTCCTGA GCTTGGGCCA AGCTATCTTT GGCAGAAATT TAGTTTATAG TTTAAATGAT

48421 AATAGCCCTT CTCCAAAACT AAACTGCCTT TGTAAAACTA ATAAAAGACC ACCAATGAAA

48481 GGTTAGGAGG ATGAGAGGAG CCTGAATTCT GCTAAGGTGT AGATGTAAAC AATTACCAAC

48541 TGTTATTCCG GAGGTCACAA GATTTGCAAC ATCGCCAATT ACTCCTGCAG ATAACAGCAC

48601 TATCATAGAA TCTGATTGGC CTTTTGAGAT GTCTTTTCAG ATTCTTACAT TTCAACTGGT

48661 GGCTCTACCT GGACCCATCA ACAAGTCCTG TGGCTCCACC CAGAAGCAGA CTTAACATGC

48721 ACAAGGACCA TTTTCCACAC CGCTATGATT GCATCCCAAC CAATCAGCAG CAACCATTCC

48781 TCTGCCTGCC AAATTATCCT TGAAAAATCT TAGCCTTAGA ATTTTGGGGG AGGCTGATTT

48841 CAGTAATAAC AAAACCCCGG TCTCCCATTT GGCTGGCTCT GCATGAATTA AATTCTTTCT

48901 CTATTGCAGT TCCCATCTTG ATAAATCACC TTTATCTGGG CAGCAAACAA AAGGAACCCA

48961 TTGGACAGTT ACACTGTTGG CAGATATATC TTGCTTCCAA AATTGGATTT TTGTTTAATG

49021 AATTTATTCT GTTTTCTTGA TATTTACAAC TGTGAATGTT GTGTCTGAAT TCTCTTTATT

49081 TCTTGTTGAA AAGAACTATA TTGCTACAGC CAGTACATAC AGATGGATAG CTAATTACTC

49141 AACACGGGGG GATGTGACCA TCACCGCACT GTGCAAATGA ATGTTACCCA TTGTCCACTT

49201 TTCCCAAACT ACATAGTGTT ATATGGTATA TGACCCAATC AACGGTGGCA AAGCTCCAGA

49261 AATACCACAT AGACATCAGG GACACTTTAA ACTAATCAGC CTATAGTCCT TTTTCAGTAA

49321 TTTCCAAACC TGGTTGTGCA TCCAAATCAC TTGGTAACAT TAAAAAAACA AAAAAATATA

49381 CACGCAACAT TCGCTCCCAA TCCTACTGAA TCAGAATATT TTGGGTTGGT TCAGGAACAT

49441 TCAGGAGTTT TTCAGGGTCC AAGGTTTATA TAATTTGAGG TCTCTCTTTG AGAAAAGGAA

49501 CGTAAAAGCG TCTTGCTTTT ATAGATCTTA CAAAGATGTA TTACCATGTA AACACATTCC

49561 TAGGACCCAG GCCCTTGTAA TTTAAAGGTT TATCTAAGTA ATGGGCCCTG AAGCTTAATT

49621 TTCATTATCT TCAGGGCAAA TTACCTGTGG GTTAGGGTTT AGGAATATAT CTCTCTGTGT

49681 ATGTGTGTGC ACATTAGCAT GTACGCTTGT GTGGATTTTT TTTTTTTTTC

49741 TGAGACAGAG TCTCGCTCTG TCGCCAGGCT GGAGTGCAGT GGCGTGATCT CTGCTCACTG

49801 CAAACTCCGC CTCCCAGGCT CAAGCGATTC TTCTGCCTCA GCCTCTTGAG TAGCTGGGAC

49861 TATAGGCACG CACCACTATG CCCAGCTAAT TTTTGTATTT TTAGTAGAGT TGGGGTTTCG

49921 CCATGTTGGC CAGGATGGTC TTGATCTCTT GACCTCGTGA TCCACCCGCC TCCACCTCCC

49981 AAAGTGCTGG GATTACAGGC GTGAGTCACC ATGCCCAGCA CTTGTGTGGA TGTTTTAAGC

50041 TCCCAGGTGA GTGAATACAA AACTAGATCT TTCCCTTCTG TAGCATCTGT ACTGTTTACT

50101 CTATGCATCT CAATATTTTT TCTTTTAGTA TCTTTCCTTT TTCTCTCTTA TTACTTCCTC

50161 TTGTGCTATT TTTACACCTC CTTTTTTAAA AAATTTTTTC CCTTTTATTT CTATTGACCT

50221 TTAGCCCTCA CAATGATTCC TACAAGCCCC ATTTCTGTAA ATGGGGATTG AAATAATTGC

50281 TGGACTTTTG AGAGATAGAT ATATTAAATT GCAAACTGGC AGTAGTGGGG GCAGTTGATA

50341 CATAACTAGG TTTTAAAGTC TAGCCTTCTG AGACCACTCA TTCCATTTGT GAAAAGTGAT

50401 TCTACTTCTT ATTATGAGCC AAAATATGCA TTCATTCACC CATGCATTGA TTTATTCATT

50461 CAATAAATAT TTGTTGGATG TCCACTCTGT ATCAGGAATG TGCTAGGTTC TGGGAATACA

50521 GCAATGAACA AGGTAATTTT TCCCTACCCC TAAGGAACTT AGAGTTTAGT GGGGAAGACA

50581 GACATTAAAC AAACAATTGT GCAAGTAATA ATCTATAATT ATTTATTACA ATTAAAGGAA

50641 GGAAGAGACA TATGGATTAT GAGGGCATTA AAGAGGAGAC CTAGTGTAAG TAGCCAGTTC

50701 TCGTGAAGGG ACATGTATTA GTTGGAGTTC TCCAGAGAAA CAGAACCAAT GGTGTGTGTG

50761 TGTGTGTGTG CGTGTGTGCG TGTGTGTGTT GGGGTGTGGG GGTGTGGTAT TTTTTATAGA

50821 AATTGTCTCA CACAATTATG GAAGCTGAGA AGTCCCATGG CCTGCTGTCT ACGAGCTGAG

50881 AACCAGGAAA GCCAGTGGAA TACTTCAAAG TCCAAAGGCC CTGGAACCAA GAGTGCCAGT

50941 GTTGGAAGGC AGGAGAAGAT GGGTGTCCCA GCTTAAAAAG ACAGTGAATT CACTCTTTTT

51001 GCTCTACATA GGGCCTCAAT GGGTTGGATC ATGGCCACCC ACATTGGTGA AGGCAATCCT

51061 CTTAGTCTAC CAATTAAATA CTAATCTCTT TGGAAATACT CTCACAGACA CACTGAGAAA EPI-109 625

51121 TAATGTTTTA TCAGGGTGAT AGAAATCTTC TGGAGTTAAA CAATGGTGAT AGCTGTACAA 51181 TCACATACAT TTTTAAAGGG TGCGTTTTAT GGAAAGTGAG TTTTATCTAA ATAAAATTTC 51241 TAAGAAAGAG ACTTAACACA GAGATAAACA TAAGCACATT TATTGTCAAC CTTTATAGTG 51301 TTATGTCAAA TAGGTCTGAC ATAAGCTTAA ATAAATATAT ACTTTAAAAA TTATAAAATA 51361 TTTTAAGTTA TAATTTAAAA TTCTCAATAA AACTCAAACA CAAACCACAC TGGTATTTCA 51421 CACAGCTAAT TTCTAATGCA GTTTACATAA ATATTTACAA CACTTAAACA ATTTCAAAGA 51481 AAATAACACT GTATTCCATA CATAGCCTGA TCACAGTAGT TGTTCTCTCT TATTTCCCAG 51541 AGTTTTTCTG CCCCTTTAAA AGAACCTCTG CTGTTCTGAT CCTTATCACA TCTCTGTTTT 51601 GACTGTTGGC TTTGTTGTTG CCAGTGTTCA GCCAGAACTT CTCTGAAACT TTTTTTTCAA 51661 CACATGCTAA GTTAATGGAA GTGTAGGAGA GTTTTGATTC TCACACTCCT CAAGGCTAGA 51721 GCAGCTTTGG CAATTACTGA CTGAGAATTT TTCATTGCCA GTGATCAACT GAAAACTGGA 51781 GATTCCTTTG GAATTGTTAA ATCTGCTTAT AAATAAACAT AAATGCTTGC TCACACAGGC 51841 ATTCCTCTCT TCCAGAGCAC CCTAACATAC AGAAGAAAAC AAATAGGGAA TAACTATTAG 51901 ACATCTTCAT TCGTTAAAAA TCTACCAGAT GACTCTTTTA CATGGTGAGT TTCTATTGTG 51961 AATTTAAAAT CTTCCATAAT ATACAAGAAT TATGTTTACA TATCATATCT GACAAACATC 52021 TTTGTAGGAA TGCAAAGCAC ATCCATCTTT CTGTATTCTT TTCCAACAAA GACATTCATA 52081 AAATTATACC TTTGTGTGTT TGCATTTATG CTTTTATTAG TTCAAAACGT TTGGCCTCAT 52141 GGAAGTTTTT CATCGTGGAA ACCACATATT TCTGAAAAAA TATCTGACAA TATACAAACC 52201 TTCCATTCAG TTTTTACTCT CCAATTCTAC CATGTTTTCA AAAAACAACT GTAGTAAAAA 52261 CACTCAGAAC TTTATTCTGG TTAACATCAT GCCTTGCTAG GGGACAATAG TTTCCCTTTT 52321 TGAAATAAAT TTAAAACAGA TGTAACATAA TTTGTTAATA AACAATGAGG GGGTAATCTA 52381 GAATAAGTAA CTTTTACCAT ATCATAGTTG ACAGCATTTA CAAGTTTTTT AAGTCCCTAC 52441 CACACTTGTA TTGAATGAAG AAGTATGGAA GATTATAATA TATTCAATGC AAGTAAAAAT 52501 ATCACAATCC TTAAGAACTC TTTAAGAAGC ACTGAATCCC ATAGGGATGA AAGTGATTAA 52561 ATTGTGCATA GTAACCCTCG CACAGAGCAT TCAGTAGGAT TTGCACCATT AACAACCCTC 52621 CATGCATTTG CCTGTGGGCA TTCAACATCT GTCATTTTTT TAAGTTATAA TATTTTTAGT

52681 CATTTTTTTC CTCTAAACTC TGGATAATTA TTATTCATTC TTATGACAGC AACTGTGTAA

52741 TCAGCTGTCG AAACACTGTG AAGGGCAAAA GAAAGAAAGC CACAAAATAT TGTGTTTCTG 52801 TGCCAAGATT TTACAGCGAG CAAGGGAGAG TTAGAAAAGG AATTCTGAGA TTTCAGAGTC

52861 TTGGTCTCTT CACCTTTGCT TGGAAGAAAA TATCCTTTCC CTTCATTAGC CAACACTTTC 52921 TTGATCCTGA GAGTAGGAAA GGGAACACTG AGTCTTTTCA GTTGAAGGCC GTCCTTGCCT 52981 GCTGGACTTT GATCTATTGA AGTGGTGATG GGTGTTGCGG TTTCAGCCAT AAAGGCATCT 53041 GGCATAGTAG GCAAGAAGGG CCAGAGACCC GAGGAGAGTT ATCTGTCTCT GTTAACTTCA 53101 GTGTATCCCT CTAGTTCCCC AGATGCACCT GTTTCTGTAA ATATAAACAT GCATGTCATC 53161 AGAACACTTA ATATTCTGCA TACTGATCAT GACAACAAAA TGTACCTTCT AACACAGACA 53221 CTCTCACTAG GATAGACCAT GTAGGAACAT CGAATTCTAT TCAGTTAGGA CAGTGATGAT 53281 GTCTACATAT TATACCTCTG TCAAAACCTA CAGAATATAC AACACAGCAC AGAGTGAATT 53341 CTAATGTAGC CTGTGGACAT TAATGAATAA TAATGTATCA ATATTGGCCC ATCAGTTGTA 53401 ACACTAATAT AAGATGTTAA TAACAGGGGG AATTGAAGGG GTGGTGGGGA GATATGTTGG 53461 AACTCTTTGT GCTTTCTGCT CAATTTTTCT GTAAACTTAA AACCGCACAC ACAAAAAAAG 53521 TTATTTTAAT TTTTTAAAAA GTATTCAGAG GGACTTGACC TTTCCAAATT CTCTCAAAGC 53581 AGGTCGGAGT AGTTAAGAAC ACAAATTTTA GAACCAGACT GCCAGAGTTT GAATCCTGGC 53641 TACACCACTT ACTAGCTTTG AGATTTCAGA CAATTTACTT AACTTCTCTG TCTCATTTTC 53701 TTCATCTGTG TGATAAGAAA TAAAGTAACA GGCCAGGCCC AGTGGCTCAC GCCTGTAATC 53761 CCAGCACTTT GAGAGGCCAA GGCGGGTGGA TCAGGAGTTC AAGATCAGCC TGGCCAACAT 53821 GACGAAAAAA TACAAAATCT CTACTAAAAA TACAAAAATT AGCTGGGTGT GGTGGCAGGC 53881 ACCTGTAATC CCAGCTACTC AGGAGGCTGA GGCAGGAGAA TTGCTTGAAC GCAGGAGGTG

53941 GAGGTTGCAG TGAGCCAAGA TCATGCCACT GCACTCCAGT CTAGGCAACA GAATGAGACT

54001 CCATCTCAAA ATTAAAAAAA AAAAAAGTAA AAAGAAAAGA TAAGAAATAT AGTACCAGCC 54061 CCTATCTCAG AGTTCCTAGC TTAGAAAAAT TCCCAGAATA TAATAAGTGC AATGTAAGGG 54121 TCAGCTATCT TCATTATTAT TATCTATCAT AAATGAAATT ACACAATAAA GCTAGATCCG 54181 TTTCTTTCCT CTCCTTCTAC AAAAAATAAA GCAACTTTCC AGAACAATAC CCAGGTGATG 54241 ATTTCTCCCC TGCTCCCTCC CTAAGATATT GGCAAGTTTG GAGGGTTCAA GGAGAAACAG 54301 AGCATGTAGA GAAGATACCT CTCTCATAAC CATTTGTGAT TTACAAGTCT TACCTGATTC 54361 TTTTGAACTT AAAGGATGTA AGAAGGCTTT TGGTAGCTTC CATCTGATTC AAGGCTTTGG 54421 CAGCTGCTGT GGAATACATG AGAACACTAG GTAAAGCACT GTCTTCCAAC ATGAAGAGAG 54481 AAAAATATGT GGAATGTTCA ATGGCATGCT TTGTATAAGA ATGCAACTTA CCTGGCAGGA 54541 ACAAATTTCT TTGCTGCAAA AGAAAAGACA AACAACCATT AATTCAGACT AAATGACTTT 54601 TAAGGATATA TTAAATCCAG ATACAATATG ACTTAATTCA TCAAGTGTTG CAAACTCGAT 54661 GCTTCAGGGC CTCTGTAATA ATCAGAGCAC AAGCATGGCT CTGTGGCATC TAGGGTAAAA 54721 TGCAAAGTGC ACAGCCATCC AAAGGGCATA GCAGCTTCCT AATGCCAGCA AATAGCTACG 54781 GGGTCATCTT GCCCAATTCA GCTCCCAATT TTTCATGAGA AGTCCAAAGT CTTAATTTAA 54841 ATGTGAGATT TCCTATTTTG TAAACGTCAG AACTTAACTC AAAAATGTTT TAAGTACTCT 54901 TAAACATGTA AGCCAAACAA ACCATGAGTG TAGTCAGATG TGCTTCCATA TTCCTTATGA 54961 GAGACTCTCA AATTTAAGCC TGTACTCCAA ATAAATCTCC TTAGGAAGAA TTTTATCCAT 55021 TTTCCTTAGA GTGCTCATCA TGGCAGTTCC ATTGCACAAT TCCGGGAGGC ATCATATAAT 55081 TCAACATGAA TAGCACCCCC TGGAGTTGTA CAATATTAGG CACGACTAAC ATTTTTATTT 55141 CCTGAAACAC TTCCCACACT GAGTTGTACT ACTAACTCTT TTCTTAATAC TTCTGCTTAA 55201 TTATACTGCA TTTTATCCAG ATTCTAATTA TTGTTTAAAT CAGTAAGCAA GACCATGACT 55261 TATCAATGAG AAAGAAATGT ATTTTCAAAA ACATTTTTGA AGTACATTCA TAAACTTCCT 55321 CACCTTTCCG TAAGCATTTC CGAAGCCAGA GGAGAAATGG TGCTAATGTC AGGAGGGAGA 55381 GTCCAGCAGC AGAAAGTCCA GCTACCAAGG GAATGTTGGA CTCAGTGGGA GCTAAGGAAG 55441 TAAGAGACGA AGAAAGGTCA TGAGGAAGAA TTGATGTTAA AGTCTCTCCG TCCTGTCCCT 55501 TTGGCCTTTT TTCTGTACAT TCATTACTAG GAGCAGAAGA GCTATCTAGT TTAATACAAG 55561 AAGCAGAGAT GTGGCATTAC AGGCCTTTGA GATCTGCTCC AAGCCACCTT TGAAGCTATT EPI-109 626

55621 TCCACCATTG GCAGGCAGAA CTCTAACTTG CCAAGCTCGT TCACAATACC ACACCACACC 55681 TTGGTTAATA AACACTGCAC TTGCTTGCTC TCTTGCTCTC ACTCCCTCTT GTTTTCCATT

55741 TCCCCTTTCT CCTCTCCTCT CTCTGTCTCC TTTTTCCAGT TGTCAGAATT CTACCCTTTC 55801 CATCAACATG CAACTTCTGT TTTTTCTCTA TCCCCATACA ACTTAATATT CACAACTTGT

55861 CAACCTGGGC GAACTTTGTG GTTTGGATAT AATGAATAGT TGATTACTGT AACAAGATAG 55921 CTCCCCCTTT TTCTTTTTAA TCACCAGACA ACCACCATCA ATCAATGCAT CACCTTCACA 55981 GGTAGGTAGC AGGCCAGACC AGTGTCCTGT GGCTCCACAT GTCCGAGCTG CAGAGCCATT 56041 GAGCGTCCAT CCTTCAGGAC AGGCGAACTT GCACACAGTG CCAAACACGG GCTCCCCACT 56101 GCAGCTCATG TTGATCTTTC CCGGAACTGC CAGGCTTGAA CATTTTACCA CTGCAAATGT 56161 TAGGTACACA GGCAGAGTTT CAGAAAAATC TACTGGAAAA CTTCCAAAAC TTGCTTAAAA 56221 GTCAACAATG AATGTAAAGT GTAAGCGCTA CTTAGTTTTC AGCATGTAGG AAATTAGGAC 56281 CAAACCCCTT TGGGGCAATC TAGGTTCAGA AACTTTATGA AGTATTTGAC CTGTACCCTA 56341 AAAAAGTCTG CACTCAATTC TACCTTGGCA GGAAGGAACC TCTTCTGTCC ATTGTCCCTG 56401 AGATGTGCAC TCAAGTTGAG TTGATCCATG TAATTCAAAT CCCTCCTCAC AGCTGAAGGC 56461 ACAAGAGGAC TTGTAGGTGA ATTCTCCAAT AGGGGAATGA GCACACCTCA CCAAACCCTT 56521 CGGGGGCTGG TGGACAGCAT CGCATCTCAC AGCTGGAACA CACGAGAGAG CACTTTAGAA 56581 GTTTGTTTGC ATCTCCAGCA ATACGTTTCC CAAGGTAACC AAGTTCCCAA GCTCTTCAAT 56641 AGTTCTTTTT ATCTTAAAAT AAAATAAAAA CAAAGACTGT ACCTTCACAT GTGGGCTTCT 56701 CGTTGTCCCA CTCCCCTGTG GGGCCACATT GGAGCCTTTT GGATCCCTTC AACACAAAAC 56761 CCTGCTCACA GGAGAACTCA CAGCTGGACC CATAACGGAA ACTGCCAGAA GCACTAGGAA 56821 GACAATTCAT GTAGCCTCGC TCGGGGTTGG ACAAGGCTGT GCACTGGAAA GCTGAGACAT 56881 CAAAATGATG GTCAGAAAAT ATTGCAGTGG AACTAGAGAG TACTTGGCGT TTGTTGAGTG 56941 AACCCAGTTC ATTCAAGCAA CACTTGGAGA ACTGAAGATT CTTTATAATT CCCTGGACAA 57001 ATGGGAAGAT GGCTGTGTTT TCTTTGAATT TCAGCCCCCT CACTGATCAT GGCACTAATT 57061 AAAAGACTAA TTAATCAGAA CATTAGTTCC TGAGCACTGT TCTTCTAACA CACAAAATAA 57121 ATTATGGTCC AAGGAAAGAT TTCACGCAGT CTGAGGACAA CATATGGGTC ATGGATGTTT 57181 ATAGATGGTG CCAAAAAGAA AGAAAAGAAA GCACCCCTAT AAAATTTGTC TGTTTTGCAG 57241 TTTGGTTTTT GTGTTATGTT TTGCTACTGG AAATCATTCT GTGCTGGCTT TGGCTAGGAC 57301 AAGGCCAGTG CCTGATAGTA AAAACTGCTT GTTTTCAATA TCCTTGCTCT CACTTTAAAG 57361 TGAATTAAAA TTTACTGCTT ATATATGCAT CAATACTATC TCTGTAGCTG ACACCATGCT 57421 TGAAACAGTC TCATCACTGC TAATTATGAG CCATTTCAGA AGACAGGTGT GATGAGAGTT 57481 TTACATTCAA ATCATGTTCT CATTATTCTG CTTTCCGAAT TTTCTAATAT GATTCCTTTA 575 1 GATTAAGAAT TCTGTCTATT CCATGCTAAT GTCTACAAAG TTTTATCAGC ACATCACAGT 57601 TAAAAAAAAA CAGCAAAGAA TTCATTCTTA ACACATATGA TCCTTTCCCT GGCCAAACAT 57661 TAGTTCTTTT AAATGAATCT CAAAGATACG AGGGTTGCTC ATCAAATCTG ATTTCTATAG 57721 TTAAAGTGGG TATTGGTTTT TTTTTTCACT GTCCAAGTTT GAAGATGGTT GTTCTTTAAG 57781 AAAGTATAAA TCGAAGGATC TCAAGCTTAC CTTCACAAAC TGGGATTTGC TGTGTCCACT 57841 GCCCTTGAGT GGTGCATTCA ACCTGGGCTG GTCCCTGCAA CATGAAGCCT TCCTCACAGG 57901 TGAAGTTGCA GGATGATTTG AAGGTGAACT CTCCAGCAGG GGAATGGCTG CACCTCACAG

57961 AGCCATTCTG AGGCTGGCGG ACGGCCCTGC ATGTCACAGC TGTAACAAAT ATACGCATTG 58021 ATATTAGCAC GGCCTAGAAT TAGCTTGCCC ATTTCCAGTA TGGGTTGAGA GAAAGAATGT 58081 TCACAGTAAG TCTCCATGTG GAACAACTCT ACCTTTACAC GTTGGCTTCT CGTTGTCCCA 58141 ATTCCCAGAT GAGGTACACT GAAGGCTCTG GGCTCCCATT AGTTCAAATC CTTCTTCACA 58201 GTCAAATGTA CAGGTTGTGT TCCATGGGAA GCTTCCAGGG TTTTGGAAAC ATTCCACGAA 58261 CCCATTGGCT GGATTTGTCA CAGCATCACA CTCAACCACT GAGGATTTTA AAGAGCACCA 58321 TGAATTTTAC AGAAGAATGA TCTTTTCACT TCCTATTGAG CTGGGTGCCT AACAGAGTGA 58381 GGAAGCTGCC TTCAAAGGGT AGATCCCAAA GTCCTATGTC AATTCTTAGG GACATGCACA 58441 GCCAGAATAA AAGCTTTTAT TCTTTTTCAT GGATATTCTA TCTTTTCTGA TTTCCACTTT 58501 GCCTATGCTG AGTGGTCTCT AATCTATGTT ATCATTTACG TGAGGTAAAA ATTTAAAAAA 58561 AATAGATTCC AGATTAGGAG TTATGACTAG TACTGACATA CGTAGGCTAT TCATTTATTT 58621 TAGCCCATCA GAGCCTGAAG AACTGATTTT TCTTTTTTTG GCCTCTGGTT CAGAAAGATA

58681 AAATTAAGAG AGAAAAAGAG ATACTAAGAC TGCTTGACTA TCATGGTCTT AAGTTAGTCC 58741 CATGGCTTGG AAAAGTTAAA CAGGGAAACA AGATGAGAAA TCCATTGAGA TTTCTAGAGC 58801 TTTATTGTTT TATGGTCTCC CTTACAAATC ACCAGAGCCT CAGAAACACC CATTTCAAGC 58861 ATAGAATAAA AAAACCTCTC TCAACCCAAG CAGGTACTGG GTTGGCAATA TACATTGGCT 58921 GAGAGAACAA ATTGTATTAA AAACAAAAAC AAAAAAAAAA CTTTCCCTGA AGTTTTGAAA 58981 ATGTAAGTTG AATCAAAAAA CAGAAGCAAT GAGGGATGAG TTACAGAACG TTCTGTGCAT 59041 TCTCAGAGGG ATTTACCATT GCAGGCTGGA ATAGGAGCAC TCCATTCTCC AGAGGACATA 59101 CACTGCATGG TCTCCATGCT GCTTGGCAGG TAACCCCTAT CACAGCTGAT AGAGCAGGAA 59161 GAATTGTAGC TGAAGTTTCC CAGTGGGTGA CTGCAAACCA GGCTTCCATG CTCAGGGGAT 59221 TCCAGGGCTG TACAGTTCAC AACTGAAAAA GAAACCCAAA TCAGTTCTGC TCATCTCTCA 59281 CCTTTAACAG ATAAGAACAC TGGAAACTAG AACTACAGTT TGGTTTTTTT TTTTTTTAGT 59341 TTAAAAATTT ATAAAATTTC TAATGGAATT TGTAAAATTG ACTGTAATTC TACCCCTTTT 59401 CTTTTATTCA AGAAAATGCT GATCCATAAC AACAACAACA AAAAAGCAGT GATGACAACC 59461 ATAAAAAAGA AATATTGAGT GATATGGGGA GAGTAGTGTA ATTGTGTTTA CCTCAAAACT 59521 GTTCAAATTA TATGAACAAA CACAGCAAAC TTAGGTACCA CAACAAATTT CTTGTTACTT 59581 TTCTCACAAC TGCTAAAAAT ACTACAGTAA GCTTCCAACC AGGATGAGAA CCATTCACAA 59641 AGCTATATTT CAAATTTAAG TACTAGAATA CATTACAAAT TTTAAAACCC TAATGCTGCA 59701 CTGTCTACTA TAGTAGCCAC TATCTGTGTG GCTACTCAAA TTTAAACTTG AATTCGTTGA 59761 AATCAAATAA CATTTAAAAT TCAGTTCCTC AGTGTCACCA GCCACATTTC AAGTACTCAA 59821 TAACCACATG TGGCTCATAG GTACACACTG GAAAACACAG CTATGGAACA TTTCCATTAT 59881 CACAAAAGCT CTACTGCACA ACGCTGTGCT AAGGAATCTT GGAGAGAAGC TCATCTAACT 59941 CTCTTAATGT ACAAATTTAG GAACTGAGAC CTCATTTCAT TCAAGTGACT TGCTCCATGC 60001 TACACGGCTA GTCATTACAG AGCCAGAGGC CAGAGCATGA ACCAAGATAC CCTGGACTCT 60061 GTAACTCACT CATTTCTACT GCAACGTCTT GTTACCACCT AGATGAGGTG AGTACATGTT EPI-109 6₂7

60121 CCTCGCAGGG ACACAGAATT ACAGTTTATT GAATGTGTCC TGTGTGCCAG GCACCATGTA 60181 ACCATGAGCC TATGAAG7TC ACACTATTAT TATCCTCATT TTACAATGAG AAAACTGACA 60241 TAGAGAGTTA AACTATCTTG TCAAGGTGCC AAAATAAATA ACTGGTGAAT CTAGGACTCA 60301 AACCCAGCAG GGTCTGACTT CATAGTCTCA GCTCACGATC ACCATATGAC ACCATCTGCA 60361 CCAGGGAAGG GAAGGCATGC AGACCTGACT CTAATGCCAG CTAGGACGTG AGATGGTGCT 60421 ACCATCTCAA GTGAAGAAAG AGGCAAGAAC CAGACTTACT TTGCTCACAC TTGAGTCCAC 60481 TGAAGCCAGG GTCACACTTG CAAGTGTAAT TATTGATGGT CTCTACACAT TCACCGTGGC 60541 CACTGCAGGA TGTATTGGTA CAGGCAGCTA CGGAAAATAC AAAGCATGAT GAGGAGGACT 60601 ATTACTGTGC TTATACTGAG TGCCTTTGAT TTTAGAATCA ACAGTGTGCA ACAGAGACAT 60661 CAGCAGTCCT ACAGAGTGCC ATAGACTTTA ACTGAAGTGT TTTACAAAGT TCCAAATCTG 60721 AGTTTCAGGC CCACCT.-.TCC TAAACCTTGA TGCTAATGTA TAGCTGTGGC TGGCACCTAC 60781 CGTAGAAAAT TTACTTCTTC ACAAACTCTG AAGACAGTTC CCCTACCACA AATAAACAAG 60841 TAATTAAAAT ATGTATTGTG TGTGTGCATT TTTATATGTA AAGAACTACA TATTTGCCTA 60901 CAGTATTTAT ATATATTTTA TATATATACA TACACACATA TATGTGTGTA TATGTGTGTA 60961 TGTATATATA TAAAATGTAT ATAAATGCTG TAGGCTATAT ATATATACAC ACACACATAT 61021 ATGTGTGTGT GTATATATGT GTGTGTGTGT ATATATATAC ATATCCACAT ATTCTTGCCC 61081 ACATTCACAC AAAACAGCAA AAGAGAGAAA CTTTAGCAGT TAAACAGAAT CTTTTGGAAC 61141 ATAAAATGAC CACAATAGAG AGCAGTTTTT GCATGCTGTA AATTTGCCAA GATGCCCACA 61201 CACTGAAACT ACCTCCCACT GCTGCCGCAA ACTCCCTACC TGTGTAGCAT AGGGCAAGCT 61261 TCTTCTTGCT GCACCTCTCA TCATTCCACA TGCCCACATC TTTTTCTCTC TTGATGTAGA 61321 TCTCCACGCA GTCCTCATCT TTTTGCCTAT TGTTGGGTTC ACCTGGAGCC CAGTTCTTGG 61381 CTTCTTCTGT CAGAGGTTTC TGGGTTCCTA CCCAGACCCA CACATTGTTG ACTTTTCTGA 61441 TTCCAATCCA GTAATAACTT GGTGAATAGC TCAATATGGA GTTTAGGTAC TCAATCTCTT 61501 CTTTGTTTTG AATTGCAACC AGGTGTGTGT ACCTTTGCTG ACAATAAGCA CTGGCCTCAT 61561 CATAAGTCAT AGCTTCCGTG GAGGTGTTGT AAGACCAGGC TCCACTCTCT TTAATGAGAA 61621 GCACTAGTGG GAGAAAAAGA AAAGAAATGG TAGAGTTTGG TACTGTTGTG GTTTAACTCT 61681 GACAACTGTG CTTTTTATTG TCTTATTTTT GGCAATGTTT GTGACATGGC CCAGACTTTT 61741 CTCATCTTTT CAAAAGTAAG AAGTACGTAT GAAGAAACAG CGACTTATTG TTTATCTCTT 61801 TTGTGACTGC CACCCACTAG GTACCTTATC CACACTCACT CACAACATTA TAGTATACCC 61861 ATTTTGTAGT AGAATAATAA TCAGAATAAC TAAGCTTTAT TGAGCACTTA GTATGCACCA 61921 AGAAGCACTG TATGAGGTAC TTTCCATGAA CCATGCTATT GAATCCTCAC AATGCATCTG 61981 GGAAATAGGT CATTATGATC CACACTTTAC ACTTAAGGAA AGGGAGACAC CAAGAGGTAA 62041 AGTAAATGAC CCCAAGCCCA GGGAAGAACA CATTGCAGGT AGAGGTCAAG GATGCTGCCA 62101 GATATCCTGT GCAGGACAGC CCCAGACAAG CAAGGATATT TCAGTCTGAA ATATCTATAG 62161 TGCGAGAATG AGAAATCTTG GTCTAATGGC ACTGACTTAC CCAAAGTGAG AGCTGAGAGA 62221 AACTGTGAAG CAATCATGAC TTCAAGAGTT CTTTTCACCC AAAGGTTTAG GCTTGAAATA 62281 CTTTCCTGGG GAGATAAAAC ACAAAATGAA TTAAAGAAGG AAATCGTGGG TAGCTAGTTA 62341 CATTATTCTA CCATGATGTT TAAGGCAGCA TCCTAAGATT TTGGGCAAAG GACACTAGTG 62401 CAATAATCTT TATTTCAGAG TTTAATCAAA TAAATAAACA AATTTTAAGA CTTTCATTAT 62461 TTAGGTCAAA GAGAAAAGAC AGGTTTTAGC TACAATACAA TAAGAGCTTG TACAGATGTG 62521 GTTTTTATTA GAAGGCCTTT TGCATATCTG TGTTTCATGG CCCGAGGCTG CCCTTATAAA 62581 GCGTTCTGCA CTTACCGTTT TGGGAAGCAG TTGTTCAAAC ACAGGATCTC TCAGGTGGGT 62641 ATCACTGCTG CCTCTGTCTC AGGTCAGTAT AGGAGTTTTG ATGTGAAGTC AGCCAAGAAC 62701 AGCTGAACAC TACTTCGGCT GAGGCCCTTT TATAGGAGGG ATTGCTTCCT GTGAATAATA 62761 GGAGGATATT GTCCACATCC AGTAAAGAGG AAATCCCCAA TGGCATCCAA AAACTTTCCC 62821 GGGAATATCC ACGATGCTTA AAATTACAAT GATGTCAGAA ACTCTGTCTC TTGAAGCTAC 62881 TTCACCTTTG TCCATGCCTT TATATCGTAT ATGCAATTTT ATTAATATGA CAAAAATGCA 62941 TGATTTTTAA TTATAATAAC ATAAAGTCTA TGTCTTTAAA AAGTTGTAAA ACTTTGCTTG 63001 TTAGTAGTGT CTCTCATGTA GTTGTGGTAG TAATTAGAAT TTCAGAAACA GAAGGAAACC 63061 AAGAATAGGT TTGTCATCCA TAGTCTACTA CCTTCAATTT CTCATTCATA GCTGTGGATA 63121 ACCAATCACT ACTCATTTTT TCTTCCTTTT TCACCTGCCA ATTCAACATA TTTAACATGC 63181 ACTGTCTCAC AGAGGAATGA CTCACAAGGT AGATATTAAT CTTCAGATTT TGCACGGCAG 63241 TTATGCCTAA ATTAAAATAT TATCTAAAAA TAATATCTAA CACTCAAATG GTTAAAATAA 63301 TGCCTTATTT TAAAAAAAGA AAAATGGGAA ATAGATATTT ACATCTGGGA AAGTTTCATG 63361 GTTTGTTCAG TGAAAAAAAT AAAAAGGAGG CCAGGCACAG TGGCTCACGC CTGTAATCCC 63421 ACCACTTTGG GAGGCCGAGG CAGGCGGATC ACCTGAGGCC GGGAGTTCAA GACCAGCCTG 63481 ACCAACATGG AGAAACGCCA TCTCTACTAA AAATACAAAA TTAGCTGGGC ATGGTGGCGC 63541 ATGCCTGTAA TCCCAGCTAC TCGGGAGGCT GAGGCAGGAG AATCGCTTGA ACCCGGGAAG 63601 TGGAGGTTGC AGTGAGCCAA GATCACGCCA GTGCACTCCA GCCTGGGAAA CGAGTGAAAC 63661 TCTGTCTTAA AAAAAAAAAA AAAAAAAGAA AAGAAAAGAA AAAAAATAAA ACGGAAAACT 63721 ATATATATAT ATTTAATTGG TCAAAATTTT GTTTAAAATT TTTGAAATGT TAATGTGCAA 63781 AGAATAAAAA TTCTTCCACA ATGTTAACAG TGACTAACTC TGGATGGCAG GATTTGGGAT 63841 AATTTTTATA TCCTTCATTA TTATTTTCAG GATTTTAAAG TTTTTTTCAA TTTCCCTTTT 63901 TTTCACCTTT ATAGTAACAA GAATACAGTT TAAAGAAACT TGTCTCTAGG CCAGGCATGA 63961 TGGCTCATGC CTGTAATCCC AGCACTTTGG GAGGCTGAGG TGGGTGGATC ACCTGAGGTC 64021 AGGAGTTCCA GACCAGCGTG GCCAATATGG TGAAACCCTG TCTCTACTAA AAATACAAAA 64081 ATTAGCCGGG GTGTAGTGGC GCATGCCTGT AATCCCAGCT ACTGGGGAGC CTGATGCAAG 64141 AGAATCGCTT GAACCCAGGA GGCAGAGGTT GCAGTGAGCT GAAATCACAC CATTGCACTC 64201 CAGCCTGGGC GACAGAGCAA GACTCCATCT CAAAAAAAAA GAAAAAAAGA AAAAGAAAAG 64261 AAAAGAAATT TGTTTCCAAA TGCAACAGAA GGAGATGTAT GTGGTATCCT ATATTCCTGC 64321 TCTTCATTTT GACATTTCTT CTGGGTGATT GTATACATTC CCCATCTCTG CATCTTACCC 64381 TATCTAAATG ATGGTAACAG TAAATGGGGA TCATTTTAAT TTCCATATTC TGTAGGTTTT 64441 CAGAGCTCAA GTCAAGCTAA TATTCTATAT CTACAGCCTT TCAAAATAGG AGGTCTATCT 64501 AAAAATGTAC TGTCAGCAGA CCTGAACGAG TAGTGGTAAA AGCCTCGTTT TTCTCTTTAC 64561 TTGTTAGCAC TGGTCTTTCT GTGTTCATAA AGATGTCAAG ACCCAAAAAA AAAACAAGAA EPI-109 628

64 621 AAGAGAAGAA AAATTCCAAA AAAGACAACT GATTAGAAAA AAATAACTTA ATTAACGAAT 64681 TTAATTCAAC CCCTATCAAA AAGCATAGAA TTTATTCCCT CCACCTTACC ACTCTCTTAC 64741 ATGATCCAGA TACTGACATT ATTCCAATTC TTTATCCCAC TTTACTTAGC TCAATGTGGT 64801 TGTTGCTTCA ATAAATTCAG AAGAGTAATC ACTCATATAG TGTTTATTTA GATTTTAGGG 64861 CAGAATGTCA AGTTGGGTTA ATACATTATC TGTATGTATT TTATTTTTAA TAAAGTATGA 64921 ATACATAATC TGCTATTTTT AAAAAGCATG GTCAAATGTA TAGAGTAGCC AAATCTTAAA 64981 AAACAATTTA TCTTCGATAT CAATAAAGTA CCTAATAATT ATATTGCTAA TAGAAATTAG 65041 TCGTTAACAT CCCTAGATAA CTAACTTTAT TATTGCGAAT TTTTCATAAC TAAGTTTATA 65101 GTTTATCTCT TCCCCTTTTT AAAATTAGTT CAAAGATATC TAAAAATAGC CCCAGTGGTG 65161 ATGAAGTTTC TATTTTACTT ACATATATAT GTCCTGGACC CCCAATTATA ATCTCTAACA 65221 TTTATTGAGT GCTTACTATG TGCCAGGCCA TATTCTGAGC ATTTTGTATG TTCACCTATT 65281 GATTATTCAA TCCGTACAAC AGCCTATGAA ATAGGTACTC CTATTATCCC CATTTTACAG 65341 ATGAGGAAAT TGAGAATGTG GGGATTTTAT CTCATTCAAA AGCACAGAGC TAAGGGTTGA 65401 AACCAGGCAG TTGATATCCA GAGCCCACTC CCTTACCTGC TACTCCAAAC CATGATTTCT 65461 TTTGTTGTTA TGCCCCGAGA TTCCTTGTTC TACCCAAGTT TCCTGTACTC TTCTTGCCCT 65521 CTTCTTCCTG AGACATCCTT GACCATCACA GCTCTCCACT GAGATAACTG TGTCCTGGGT 65581 TCTGAGACAT GGGGGCTGGA AGGGACCCCA GGGACAGTGA GCAGTAGGGA GAGGATGCAG 65641 TGAGAACAGA CCCTGGATCC CCGGTGCATA GGCAGGGAGA AAGTGGACAA AGGAAAAAAC 65701 AAGCAAGGCA GGTGGAGCCA TGCCTAGGTA AAGTTGATCC CTAAGCCACA GTTCCCAGAA 65761 GTTCCTGATT CAAAAGCAAA TTTTCTCTAA GGTCAAAGGG CAAACTGATT ATTCTAAATT 65821 CTAAACTGAT TATTTCTAAA TTGAGAAAGC TTCAGGGAGA GATCCCAATA TTCGAAGGAT 65881 AAGAGAAATG AGGAGTGGAA GAGATAGGTG AGTAACAGTA ACTTAAATGT AGACTATATA 65941 TAATATATAA TATATGTAGA GTATATATAT ATAATTACAA TATATTATAT ATGTGGAATA 66001 TATAT ATTAT TTATATATAT TTATATATTT TATATATATA GATATTTTTA TATTTTATAT 66061 ATAAATATAG ATATTTTTAT ATTTTATATA TAAATATAGA TATTTTTATA TATATTATAT 66121 ATAAATATAT GTAAAATACT GTGAAAGAAG AATAGAATCT TGAGACCTCA AATTCACTAT 66181 GCCAAAGGGA AAGTTAAGCT TGGGAAATGA GTCATGCAAA AACTGCCTTC CTTTTGTTCC 66241 CAAATACCTG TAATTTCACA TGCTTACTTT ATCTTATATA AAATGTAGAT GTACTGAGCA 66301 TGAGATCCAT GCATAATTTC CCTCTAGTCC CTTCTTTTTA CATGTAAAGT GTAGACTCAC 66361 TGAGTGTTAC AGAGCCTTGC CACAATGTAA ACACTTGTCT CATTGCCAAC CCATCTTTCG 66421 TTTATTTTCT TCCCCTCCTG CTTGCTCTTT CCCCTCTAAA GATGGAAGTT CCCAAAACTC 66481 TCTTTGGAAA AAGCGCAGGT CACAGATCCT ACAGTGATTT GTGTTTCTTT TACCTGGGAC 66541 AAAATAAACC TCTAATCTGT TGAGATATGC TTCAGTTACT TTTTGGTTTA CAATATGTAC 66601 ATGTATGTAT ATAATTTATA TGTATATAAT ATATGTACTT GTTTTAACCA GAGGTATGTT 66661 ATTCAAAATC CATTCATCCT TACAATTACC TGCATTCTCC CACAGTATTT TCTGTGTCCC 66721 TGCCCCCGAG GTTGTCACTG CAAATCAGGT ACATGGATAC TGGGAGCTGA TGGGCTCCCC 66781 TCTGGCTACC TGGGCTGCTG AAGGGGCCAT AGACAGACCC AGCTTTCCTC TCGTGGAGAG 66841 GCCCTGGGCC AGCGCTGCGT GGGAGTGGGA TTACAACCAG ACTATAGCTT CTTCACCTGC 66901 TTTTTCCTAT CAGGATTTCA TAAGAGGCAA TTGCTTGTTT TTTGAGGGTG GGGGCAAATC 66961 AGGGGGAGTT GAAGAGGAAA TTGGGTAAGA TTTGAATAGT TGGGCATGTT GAATATTATG 67021 AATATCATCT CCCTCTTCAA ATAATCCAAA ATATACCCCC AAGAAACAGG CTGATTAGAG 67081 GTGCTTCAAG GCTCCACTGA ATCTCCCAAG CTCTGAAGAT GTAGCTAGCT GTTACCGGAT 67141 TGCCGGTTTT CAAGCCTCGC CTCACATGGA CCCTCTTGGC AGTTTCTCGC ATGGGGGAAG 67201 CATCCGCTAC ATAGATGGGA ATGAAAAGAG GAAAGAAGAC GGTGCAAACT CAGGCACACC 67261 CCGGTGTCTG CCACCAGTGC TATTTAATCT CTGAGGTGTC ACCCTTCCTG GCTTTATTGT 67321 CTCTTCCTGG AAGTCTCTTG TCCTCTCCTC CACACCCTTT AATCAGGCAT CAAAGACTTT 67381 AACCAGTTTT GCTGTGTGCC CAGGCCCACT CATTCTCACT TTTATGGCAA AGGGAGTGGG 67441 AGACAGAGAG ATAGCCAGAA AGAAGAGATT GGGGACCCCA AGACAAATGT TAGAATTTTA 67501 ACCAAGGCCA CCCTGTGGAC AGGAGATTAT TGGGTTTAGT GGAAAGCAGC ACTGGCCACA 67561 ACCACACGTG GCAAAAGCAT CTATCGAGGA GTGAAGTTAT ATTTGGTGAA TGTGACCGGG 67621 AAGCAGGGGC AGTGGTGTCC TCCTGCCTTC CTGAGGCACT CTGTTCCCTT ACCTCTGCGA 67681 AGGCTTATTT TACCCCTGAG TGCTTAGTTT TGAAAGCCTT AGTTCCCTCT CTCCCATAAA 67741 AAAGCTCTAC TCTGCTAACA TCTAAGTTAC CTTTGCAGAG TCTTAGGTAG AGGGAGGAAA 67801 TCCCAATAAA GATTCCACCC TATCTGCAAA ATACAAACAT GGTATTTCTT GCATTCCCAA 67861 AATTGTGAAA GAAAATGTGT ATCACCACAG TAGAGAATGG CATTTTTTGT TTGATCAAAA 67921 CCTAAATATA TTTGATGAAA ATGTGTCTGG TTCTAAGTTT ATTTCCCAGA AAGCCATGTT

67981 TACTCACTTG GAATTTATAG ACATCTTATA ATATCTGAGT CGAGTAGGAG CTCCGGGCTC 68041 TACCTCACTC TTTTCTCCCA CACCCAGGGG GAAGTGTAGG GTTCTCAGAC TTTAGAATAA 68101 AGAGGAATCA CCTGGACAAC TCACCTAAAA TGCACATCTT CAGGTCTCAT ACTCAGAGGC 68161 TCTGACTCAA CAGGTCTGGG TGGCGCCCAA GAATTTGGGC TTTAAATGAG TATCTCAGAT 68221 GATTCTAATA CAGAATGTGT AAGATGACCA GATCCTATCA CACTTAGATG TATTGGCCTA 68281 GGGCCACCTA ACTTGGAGAA AATGTTAGTA AGACCCCGTG GTTGGTGCTC AGCTATAGGT 68341 ACCAGAATTT TGATCAAAAT TTACTATCAT TGTGACACTT CTCTTCGGAA CTGGAAGGCC 68401 AGAACCCCAC TTGTAAAGTG CTGGGAAAAT ACAAGGAAAA TTTAGGGTGA GTAGCATTTT 68461 GAATTCTTAC ACATGGAAAG TAAATGTATA AGAATTCTTA CCAATAAAAA AAAAGCAAGA 68521 GAGAATAGCT GCTAAAGAAT TAACACAAAT ATGTATATAT TAGTTATTCT CTTTTCTCCT 68581 CTGATTCCAG AGGACTTTGT AATTCCACTA ATTCTTCTTG AGCTTCCAGG ATGATCTGAG

68641 ACTTGAATTT TTCATGTGCT TTTTGCTTCC TATTTGGCAG CATCTTATCT TGAAGTTTCC 68701 GCTTTCTGCT TGGGGACCTA AAAACTAACT AATGGGAATT TCTTCAAAAT GAGCAAACTC 68761 TGGTGAATTC CCAAAGCGGA AGAAACAAGT GAGGATCGGG CTGGTTAATT AAGAGAACTT 68821 TTCCTGAATG TAGCCAGACT GTTTGCCGAC TGTTGTTAAC ATGAGGGAAG AAATACCCCT 68881 GGATTTTAGA AGAGCCCCTT GTTTGTTTTC CTTGGCCATT TGTGCTGCTT GTTTTGTAAG 68941 TCAGAAATTT CCTGAAGGAC TATTATTAGC TTTGTTCTCA CGTCAGAAAA CTTCTGCTCT 69001 GGCCACTTTT AAACATATAA CTTGGATTTT ACTGTATTAG AAAATGTAAC AATTACAGAC 69061 AGCACTAAAA GGACACCAAA GGGCAAAGAA AATGGGTAAC TTTTTTTTCT TCCCCAAATC EPI-109 629

69121 TAAAATAGGT GATTTTGGAG AAGTAGGAGA AAAACCTGGA TTTTCTAGAT CTCTTTAGAG 69181 CTCAACAACT GATATAGTTA ATTATGTAAG TCTTTGATAT TTGGAAATGA TTGGATTAAC 69241 CGGATAACAA TGAATATTTA AATACAGTGA TTTGGCCAGG AGCAGTGGCT CATGCCTGTA 69301 ATCCCAGCAT TTGGGGAGGC TGAGGCGGGT GGATCACCTA AGGCCGGGAG TTCCAGACCA 69361 GCCTGGCCAA CATGGTGAAA CCCCATCTCT ACTAAAAATA CAAAATTAGC CAGGCGTGGT 69421 GGTGCAAGAC TGTAATCCCA GCAACTCGGG AGGCTGAGGC AGGAGAATTG CTTGAACCCG 69481 GGAGGCAGAG GTTGCAGTGA GCCAAGATCA CGCCATTGCA CTCCAGCCTG GGCAACAAGA 69541 GCGAAATTCC ATCTCAATAA ATAAATAAAT AAATACAGTG ATTTAACACA AGAGATTTCT 69601 ATTTCACACT AATGAGCTCT GTCACTGGGG CAAGCTTCTT TGCCTCATTA AGTCTCAGAT 69661 TTCCCGAGAG CTTATTTATT TATACCAAGA GTGCTTTACT ACCGTCTCTG CTAGCTGTGA 69721 CATAATATGA CAAAAGGTAT AAATATGGGA AAAGGCACTA ATTTATATCA AAGCGTTCTT 69781 CGTTTTTCCT TGCTGTGAAG TTTTTAGCTA ATAATTCATA AGAATATACC ATATTTAGAG 698 1 TGTTTACTAT GCATGGGCCT GGCACTTCAC ATACATTGCT TCTTACAAAT TTTACAAAGT 69901 GAAAGGTAGA TATTAATCTC ATTTTATGGA GGACAAGATA GAGATCTGGA GAGGTTACAT 69961 AACTTGCCAG TGTTTTTTCA GTTAATAAAT GGTAGGGTGG AGATTCAATC TGTGTTACTC 70021 TAAAGTCCGT GTCCTTTTTA TTGGCTCCAT GCCTACTCAG ATTTAAATCT CAGCAGGGAA 70081 GTAAACCTTA GTTTTTACAT GAGAAAATGT TACAGCAGCC TTCTCGGCTT CCTTTACCCC 70141 CATCCCAGTT TCACGAGCTT AGTGCCTTAG ATCGGGTTCC TTTAGAAGCA GACCTCGAAA 70201 TAAGGATGTG GGTGCCAGTC ATTTATTGAA AAGATGATCC CAAGAAAGCC TAGTAGGAGA 70261 GTGAGGAAGT GAGATGGGGA AAGGAAGAAA CTCCACAAGA AGTGTGTTAA TAAGCAGGTT 70321 ACCGCTGTGG GCAGCCATGG GGCTCAGCTG CACTAACAAA CTCTGTCTAG TACAGAAAAC 70381 CTCAGGGTCT CCCCAAGGAG GGGCAAGAAG TCTGCCTAGG GTATATATCC GCCAACTCAG 70441 TCACTGGCTG AGAGCTGATC CTGGGAGGGC ATGGTTAATT CCTCTGCACT TTCAAGTGGA 70501 TTCCTGTGGT CAGAAAAAGC CCTCTACAAT GAATTCCAGA TGCTTGTATT TAAATCTGAC 70561 ATGATCTGAA TGCTGTGTTG GGACAGGGTG GGCGTTATTA GTTTTCTGTC ATTACTGTAA 70621 CAGATTACTA CAAACCTGAT GGCTGCAAAC AACACATATT TATTATGTCA TAGTTTGTGT 70681 GGGTCAGAAG TACAGGTTAG CTCAACTAGT TTCTCTGCTC TAGGTTTCAC ATTGCCAATA 70741 TCAAGGTGTC ATCCAGTTGG GCTCTTCTTG GGAGGCTTGG GGATGAATCC ACTTTCAAGC 70801 TCATTCAGAT TGTTGGCAGA ATCCAGTTCC TTGTGGTTGC AGGACCAAGG TCCCTGTTGC 70861 CTTGCTGGCT GTTGGCCAGG AGTCATTCTT AGCTTCTAGA GACTACCTGT ACTCTCTGAC 70921 TCGTGTCTCC ACTTCACCTT TCAAACCAGC AGCGGCTAGT CGAGTCCCTC TCTTCAAATG 70981 TCTCCAACTG TGCCTTCACC TCATTTCTCC TCTGTGTACC ATGTCTGCCT CTACTGCTTG 71041 TAAGGGCTCA TGGGATTACA TTGGATTTAT TCAATCCAGG ATAATCTCCA TATTTTAAGG 71101 CTAGCTGACT AGTGATCTTA ATTCCATCTA CAAAGTCCCT TCCAATAGTA CTGTATTAGT 71161 CCATTTTCAT GCTACTGATA AAGACATACC CAAGACTGGG CAATTCACAA AAGAAAGAGG 71221 TTTAATTAGA TTTACAGTTC CACATGGCTG GGGAAGCCTC ACAATCATGG CAGAAGTCAA 71281 GGAAGAGCAA GTCATGTCTT ACATAGATGG CAGCAGGCAA AGAGAGAGAG CTTGTGCAGG 71341 GAACTCCTCT TTTTAAAACC ATCAGATCTC ATAATACTTA TTCACTATCA CAAGAACAGC 71401 ATGGGAAAGT CTTGCCCCCA TGATTCAATT ACTCCCACCA GGTCCCTCCC ACAACATGCA 71461 GGAATTCAAG ATGAGATTTG TGTGGGGACA CAGCCAAACC ATATCAAGTA CCTAGATTCA 71521 TGTTTGATTA AACAACCAGG GAGCAGAAAT CTTCAGGAGT GGGGGGCATC TTTAGAATTC 71581 TGCCCACCAA GGCTGGGCGC GGTGGCTCAC ACCTGTAATC CCAGCACTTT GGGAGGCCAA 71641 GGTGGGTGGA TCATGAGGTC AAGAGATCGA GACCACCCTG GCCATGGTGA AACCCCATTT 71701 CTACTAAAAA TACAAAAATT AGCCAGGTAT GGTGGTGGGC ACCTGTAGTC CCAGCTACTC 71761 AGGAGGCTGA GGTAGGAGAA TCACTTGAAC CCAGGAAGCG GAGGTTGCAG TGAGCCAAGA 71821 TTGCGCCGCT GCACTCCAGC CTGGGAGACA GAGCAAGACT GTCTCAAAAA AAAAGAATTC 71881 TGCCCATCAT AGTAGGCTGT CCTACAGAGA CATAACCCAG GAATTAGGTG AATGGCTAAC 71941 CTAAATTAGC ACTGTGATGT GTTTTCTGAC TTGGTCCTTA TAGCTCCTCT GCTTAGATGT 72001 GGAACTAATC CATGAATGCA AGGGTTTGTC TAGAGTTTTA AGTGGGAGTT AAATATCCAA 72061 AGTACAGGAG ATATTATGGG TGCCTCATCC ATGTCCCCTT GGCATTTATC TTTCTTGGAT 72121 AACCCAACTC TATTAGTTTT TATATCTCAC TTGTTCCTAT ACTCTGTGAA CTGATGTCCC 72181 ATAAATAGAC ATTTCATTTT GCCAGTCTTC TTGAACAATA ATTACGATTA TTAATCTAGC 72241 AGTTATCATT AATTGGCCAC TTCACATTAG ACACAGCACT TAGGACTTAA GAATACCATG 72301 TCATTTGATC ATCATAATAT GGTCAGGAAT TAAGTATTGC TATCCAAATT TTACAAAGAA 72361 GGCACTGAGG GTTAGAGTTT AAATAACTTG CTTAAGATGT CATAGCCTGT AAGTGACAAA 72421 ACTAGGACTC AAATACAGGT CCATCTGACT CCAAAGTCTA TGTTCTTGGC TACCACACTG 72481 CCTCTCCTAC AAGTGACCTG TGGTTTTACT ACTATATTCA CACTCTACTA ACTTTACCAT 72541 CTCCCATGAG TCTGTCTAGA GGAGGGCACA CACAGCACAG AAAACACATG AATGCAAAAT 72601 AAGGAAGGGC CTACTTACTA CACAGAGCCA TTCTAATACC TGATGTTTGC TCTAATCCAG 72661 TTTTACTATT AATTAGTTGC TGGTGCCCAA GTTTTTACTG AGAAATGGGG ATAATTTTGG 72721 AAGTCATAAT GATGCCTTCT TCTCATAGGG TATTTTATTT GTTGTTGTAT CTCCAGGCCC 72781 CAACACAGCC TGGCTTTTAG TAAATGATCA AAAATACCTG TTGAATGAAT AAATGGAGTC 72841 ACCTGAAACA TGTTAAACAT TTGTTCATGT GTCCTAATCG TGGATTTCAG GATAGTAAGC 72901 ATCCTAAAAG GAAAGCATGC ACACTGTTCT TGCTACATTA ATTTCTCACA ATATAAAAAA 72961 AGAAAAGCAT CTGAAAAAAG CTGCCAGCCG CTGTGTCTCC TAATATCAAA CTGAGCACAG 73021 ATATGGAGAA GCTAAGGGAG AGGGATGATG GGCCATGCCT CTAACCTCAT CATGGCAAAA 73081 GTCCTGGGGG TCAGACCCGA GGAGAGCAGG AAGTGTCTTT TGAGGGATAC ATTTCCACAG 73141 TGGAAATAAT GAGACTTAAA TAAATATTAT ATACACAGTT CAACTGTTTT TATGTGTAAA 73201 GGTAGTAGGT TTTCACAGTA AGGAAGCACT TCTTTTTTTT TTTGTTTGAG ACAGAGTCTC 73261 GCTCTGTCTC CCAGCCTGGA GTACAGTGGT GCTATCTCGG CTCACTGCAA TCTCTGCCTC 73321 CTGGATTCAA GTGATTCTCC TGCCTCAGCC TCCCGAGTAG CTGGGACAAC AGGTGTGTGC 73381 CATTACACCT GGCTAATTTT TGTATTTTTA GCAGAGATGC GGTTTCACCA TGTTGGCCAG 73441 GCTGATCTCG AACTCCTGAC CTCAGGTGTT CTGCCCGCCT CTGCCTCCCA ATGTGCTGGG 73501 ATTACAGGCA TGAGCCACTG CACTCACCAA GCACTTCTAC TGATAGCATT TACAAACCCT 73561 TCTTAGAATA TTTAAAAATT CTAAGAGAAG AGTAAATTGA GCCTTCCCAA CTAATACTAG EPI-109 630

73621 GAGGTTATAA CCTTCATACC AAAACTGGAC AATGCTTGCA CAAAAGAAGG AAGCCAATGA 73681 GGCCACCTAG AAGGAAGACT GGGCATTGGG CCCAGTGAGT CCTGGAAACC TCATCTGTGC 73741 CAGCCACCCC GGCATGGCCT GTATGAGTGG ATGAGGGTGA CTTGTCCACA GACAATAGCC 73801 ATCTAGCTGT GATAAAGGAG TCAAGGTAGT CAGCTGCATC TCTTTCACCT GTTTGCCAAT 73861 GTTACACAGG TTGAAAAGCT AAGGTTTATG TAAAGCAAGC ATCAAAGATG ATGAAATGAT 73921 CAACCTGACA ATGAGTACTA TGCTGCATTG TCCAGAAAGG AACTGTGGAA GATTTTGGGC 73981 TGAATTTCAA AACAGAATTT CCTCACTCTC TGGATGTTGG CTTACTTGGC CTTTGATGTT 74041 CAGAGGTGGT GCCTTTGTGT TGTTGAACAA TGTTGATTTT GGAGAGAAAA CAGAGTTGAA 74101 AAACCCACAA GTCATTCCCT GGGGAGTATT ACCGGAATAC AGAGGATAAT TTCAGCAAGC 74161 CAGCAAGGCC TCATCTCTGC TTCTAATAGA TAGGAAGAAA GGAAGAGAGG AACAATACTT 74221 TTTTAAGAAG CTCAGCTTTA TCGCCTTATC TCATAGAAAG ATGCCTCCAG TCTGTCTGGC 74281 TAAAGGTAAT TGGCATGGGA AAGTCTTTAT CTGTGATTCT AACAAGTGGA ATGTTTCCCT 74341 TCATTAAGAG AGCCTTGTCT GGCTTGGGGA AATGAAACAC TTTCTCCGAT ATGAGTGGGC 74401 TGTAACCCCT GCTACTAAAT ACTCAGAAGA AATAAGGCGG TTGTGGAGCA GTCAGGAATG 74461 AGTCACTTGC CTCCCTGGAA TATTCAGAAA ACTGAATCAA AAGTACATTC TTCTGGGTTT 74521 TCTTAGTCTA ATAGACTAAG GGTCTCTACT TTGTTAAATT TCTGGGAAAC AGCATAGAAT 74581 GGGAGAAAAA ACTGGTCACT GTAGTCATGC AAATCTGCAA AACAAACAAA AAAGTCTGGG 74641 TATTGCTGCT AACTAGCTAT GTGACCTTAA GCAAGGTATT AACTCTCTCT GAATTTCAGG 74701 TTCTTCATCT GTTAAATAGC ATATCTGTAA AATGGGAATT ATTTTCATAT CATAATGCTG 74761 TAGCTTTAAA AAATAAAATA AAATGGATGA GATAATCAGA ATTAAAGAGC CTGGGATATA 74821 TAGTTAATAT ATAGCAGCAT GTAAAGATCC TGTTAGAAAT GCTAATTTTA CAGTTAACCA 74881 TTTGGAGATG ATCCGCCAAA GCTGCTAGTG TAGAGGCAAC TGAGAATTTG CCTGTCCTTC 74941 AGAATATGAA TAAATAACTG TCAATGATGT CTCAAGCCTA GAAAAACCTA TCCATCTGGA 75001 TGGGTGGGAA ATTTCTAGGC TAGTATTGAG AAGCCCATTT CTTGGGAAAT AGGTCCTGGA 75061 CTGAGTGAAG GAAAAGAAAC AGTAAAACCC ATGGTAAAGC AGCAAGGCTC TCTAGAGGCT 75121 CTGGAGAGGA TGAATTGAAT TCTAGAAGAT GAAGTAGGGA AGACGCTTTA CCTTCTTGTG 75181 AAATGGATTC AAAGATTCAA AGACCTTCGG GAATCTCCAA TTGTATAAAT GGCACCATAG 75241 CTGTATGTTC CATGGAACAC TACTTCCCAG AGATGCCCAG TGAAAAAAGA ATGCCACAGT 75301 CAAATAAGTT TGGAAACACT CCATTATGTG GCCACCTCCT TGAAGACTCT AATGCACATT 75361 AGCATGTTAA ACAGTCTTGA GAAGTCCTGC AGAGCAGAAA TTGCTTCACA TCTGCTAAGC 75421 CGGCAGTTTC CCAATATACT TGATTATGGA TAGTTTTTTC CTTACAACAC CATTCTCTGA 75481 TATGCTTCCA ATGACATGAA ATAAATATAT ATGCATGAGG TTCTTCATTA GGGCATACTT 75541 TTTAATAGAA AATATTGAGA ATAATCTAAA TATAAATGCA CAGCATTTAC CTTTTCTGCA 75601 TAAACTATAT ACAGGCATAC CTTGGAGATA CTATGGGTTT GGTTCCCACA ATATCTCCAA 75661 AACCACATTC GGTTTTATGA CCACTGCCAT AAAACCAGCC ACATGAATTT TTTGGTTTCC 75721 CAATGTATAT CAAAGTTACA TTTTTACTAT ACCATAGTCT ATTATATATA CAATAGCATT 75781 ATATCTAAAA AACAACGTAA ACACCTTAAT TTAAGGCTGT GGCTGGTTTG ATTTTCTACC 75841 CAGACCACTA AAACTTTCTT CATATCAGCA ATAAGGCTGT TTCACTTTCT TACTATTTTT 75901 TGTGATAGCA CTTTTCCTTT CCTTCAAGAA TTTTTCCTTT CTATTCACAA TTTGTTTGAT 75961 ACAAGAGGAC TAGATTTTAG CTTATCTCAG TTTAAGGTGT TTACATTGTT AGCTAAAAAT 76021 GCTAATGATC ATCTGAGACT TCAGCAAGTC ATAATCTTTT GCTGGTGGAA GGTCTTGCCT 76081 CAGTGTTGAT GTCTGCTGAC TGGGTGGCTT TGGCAATTTC TTAAAGTAAG ACAACAATCA 76141 AGTTTGACAT ATCAATTGAC CCTTCCTGTC ATAAATGATT TTTTTTTTCT CTGTAGCCTG 76201 CAATGCTCTT TGATAGCATT TTACCCACAG TAGAATTTTC AAAATTGGAG TCAATCCTTT 76261 CAAACTCTGG TGCTGTTTTA TCAACTAAGT TTATGGAGTA TTAGAAATCC CTTGTTGTCA 76321 TTTCAACAAT GTTCACACCA TCTTCCCCAG GAGTATATTC TACCTCAAGA AACCACTTTC 76381 TTTGCTCATC TATAAGAAGC AGCTCCTCAT CCACTAAAGT TTTATCCTGA GATTGCAACA 76441 ATTCAGTTAC ATCTTCAGGC TCTACTTCTA ATTCTAGTTC TCTTGCTGTT TCTATCTCAT 76501 TTGTGCTTAC TTTCTCCGCT GAAGTCTTGA ACCCCTTAAA GTCACTCATG AGGGTTGGAA 76561 TCAACTTCTT ACAAACTCCT GTTGATGTTG ATATTTTGAC CTGCTCCCAT GATTCATGGG 76621 TATTCTTAAT GGCATCTAGA ATGGTGAACG TTTTCAGAAG GTTTTCAGTT GGCTTTGCCC 76681 GGATCCATCA GACGAATCCC TATCTATGGA AGCTATAGAT TTATAAAATG TATTTCTTTT 76741 TTTGTGGGGG CATAGCGTCT CACCCTGTCA CCCAACCTGG AATGCAGTGG CACAGTCATA 76801 ACTCACTGAA GACTCAAACT CCTGGGCTCA AGTGATTCTT CCACCTTGGC CTCCCAAAAC 76861 ACTGGATTAC AAGCTTGAGC CACTGTGTCT AGCCCAAAAT GTATATCATA ACTAATGAGG 76921 CTTGAAAGTC AAAGTGACTC CTTGATCCAT GGGCTACAGA ATGGACGCTG GGTTACCAGA 76981 CATGAAAACA ATACTCATCT CCTCATACAT CTCCTTCAGA GCTCCTGGGT GAGCAGGCCC 77041 ATTGTCAAAT GAGCAGTAGT ATCTTGAAAG AAATTTTTTT TCTGAGCAGT AGATCTCCAC 77101 AGTGGACTTA AAATAGTCAG TAAACTATGC TGTAAACAGA AGTGCTGTCA TCCAAGCTCT 77161 GTTTTTCCAC TGATAGGGCA AAAGCAGAGT AGATTTGGCA TAATTCTCTA GGGCCTTAGG 77221 ATTTTTGGAA TGGCAAATTG AGCATTGGCT TCAACTTTTT TTTTTTTTTT TTTTTTTGAG 77281 ACAGAGTCTT GGTCTGTCAC CCAGGCTGGA GTGCAGTGGT GCAATCTCGG CCCACTGCAA 77341 GCTCTGCCTC CTAGGTTCAC ACCATTCTCC TGCCTCTGCC TCCTGAGTAG CTGGGACTAC 77401 AGGCACCCGC CACCATGCCC GGCTAATTTT TTGTATTTTA GTACAGACGG GGTTTCGCCA 77461 TGTTAGCCAG GATGGTCTCG ATCTCCTGAC CTCGTGATCC ACCCGCCTCG GCCTCCCAAA 77521 GTGCTGGGAT TACAGGCGTG AGCCACAGCG CCCAGCCTGT CTTCAACTTA AAGTCGCCAG 77581 CTGTGTTAGC CTCTAATAAG AGAGTCTGCC TGTCCTTTCA AGCTTTGAAG CCAGGCATCA 77641 TTCTCTTCTC TAGCTATGAA AATCTTAGAT AGCATCTTCT CCCAATAGGA AGCCATTTTT 77701 TATGCCCTAA AAATCTGTCG TTTGGTGTAG CCACCTTCAT CATTGATCTT ACCTAGATCC 77761 GCTGGATAAC TTACCACAGT GTCTACATCA TTACTTCTGC TTCACCTTGC ACTTTTATGT 77821 TATGGGGATG GCTCCTTTCC TCTAACCTCA TAAACTAACC TCCACTAGCC TCACATTCTT 77881 CTTTTACAGC TTCCTCGCCT CTCTCAGAGT TCACAGAATT GAAGAATGTT GGGCCTTGGA 77941 TTACACTTTG GTTTAAGGGA ATGCTGTGGC TGGTTTGATT TTCTATCCAG AACACTAAAA 78001 CTTTCTTCAT ATCAGCAATA AGACTGTTTC ACTTTCTTAC TATTTTTTGT GATAGCACTT 78061 TTCCTTTCCT TCAAGAATTT TTCCTTTCTA TTCACAATTT GACCGTTTGA TATGAGAGGC EPI-109 631

78121 CTAGATTTTA GCCAATCTCA GTTTACACCA TGCCTTTTTC ACTAAGCTTC ATCATTTTAG 78181 CTTTTTATTT AAAGTAAGAT GTGTGACCCT TCCTTTCATT TGAACACTTA CATGATGATG 78241 CCTGGCTTCA AAGCTTGAAA GGACAGGCAG ACTCTCTTAT TAGGGGCTAA CACAGCTGGC 78301 GACTTTTAAG TTGAAGCCAA TGCTCAATTT GCCATTAGAA GCCATTGTAG GGTTAATTAA 78361 TTTGCCTAAT TTTAATATTA TGGTGTCTCA GGGAATAAGG AGGCCTGAGT AGAGGGAGGG 78421 AGATGGGGAA ACAGCCAGTC ATCAGAGCAC ACACAACATT TATCAATTAA GTTTATCACC 78481 TTGAGGGCAC AGGTCATGAT ACTTCAAAAC AATTACAATA ATAAAATAAA AAATCATTGA 78541 TCGCAGATCA CCATAACAGA TATAATGATA ATGAAAAATT TGAAGTATTG TGAGAATTAC 78601 CAAAACGTGA CACACAGACA CAAAGTGAGC ACATGTCATT GGAAAAGTGG TGCTGATAGA 78661 CTTACTTCAT GCAGGGTTGC CACAAATACT CAATCTGTAA AAAATTCAAT TATCTACATA 78721 GTACCATAAA AACAAGGTAT ACCTGTTTAT ATAATCAAGA CCAACAGAAC CCTAGAGAAA 78781 ATAGCTCACT CCCTAGCTCG GAGACATTCT AACCAACATA CACTTACCTT TCTTTTTGCT 78841 GTGTACAGAA TTCAAATCCC TGTCTCAGCA AAATTGCAAA GTATCAAATG TCATGTCCAT 78901 CTAATACTCA AAACTGCAAA TGTTAAGTCT TGTAAGCCCA GAGACCACTG TATATACAAG 78961 TGTTGCTATA AGCATTAGTT CTTCTCCAAA GAAAATAGTC CACTTGGTAG AAACAAACAA 79021 AAAGAAAAAA AAAGAAAGAA AAAACATTTT TTACAAGAAG ATTCAGTCTC TTACCTACAT 79081 AAGCAAAAAT ATGAGATGTT CTCTTATCAT TTTTCCATCT ATCTTATAAT CTTTGGTGCT 79141 GACTTAGACA CTCATTTTCC TTTTTGTACG TGACCATGTA AAAGTTCAAG TCAAGAAAAA 79201 CTTGTTTTGA CATTTGTTTT GCTGAGTGAT GGGTCCCTAA AAGAAATTTG GCTTTGCTTT 79261 TGAAAAGTTC AGCATGATAT TGTGTGAATT TTTCATGGCT AATGATTTTT AGAACAGTTG 79321 TGATGTGTTT AGGTGTTTTA AGAATATGAA GCATTCAGTG GTTTAAGTTG GTTGTTATAA 79381 AATGAAAGAA TATGAAGGAA AGCCTTCTTG TCTTAGAACA CACTGATTCA CAAATAAGCA 79441 GCTTCTCTCA AAATGTTGTA ATTACAAAAA TTCCAAGGCA AATATAATAA ACTCCTTGTC 79501 GGTGCTATGT CTAGAAACTT AACAGCCCCA AAGAAAGTCC TGACAAGGCA AAAAATATAT 79561 ATATATATAC AAATTGTGGA AGCAGGGTGT TGAAAGAAGA ATAAAGACTA TATAAGGACA 79621 AACTGTTTAA AAGGGAGGGT ATCCTTGAAA GCTTGACACT TGACTCTTTT GACGAGGCTG 79681 AGGGAAAACA CTCAGTTTCA TAGATTGCTG GTACGGATGT AAAATAGTGA CATCCCTATA 79741 GAGAGGAATT TGGCAATATC TAGCAAAAGT GCTTATGCAT TTATTCTTTG ACCTAGTAAT 79801 CCCGCTTCTA GGATTAGTGG TGAAGATACA CCTCAACAAT AAAAATATAT ATACATTAGG 79861 TTATTAGTTA TGGTTTAATT TTTAATAGCA AAATATTTAA AACAACCTAC ATGAACAAAT 79921 AGGAGACTTA CTGAATAAAC TATGGTATAT CTGTACAATA AAGTGCAATT CACTTATGTT 79981 GTTAATTTGT TCCAAAAATC CAGAGCCAAA GAGTATTTGT TATGCTCTCT TTAGTATAAG 80041 AAAGGGGAAA TAAGATATGT GTGCATCTGT TTATTTTTGT GAAAATAAGT ACAGAAAGGA 80101 TAAGTAAGAA ACTAGTAAAA CTAGTTATCT CCTAGTGTTA GTAGAAATAG AATGAAAGTG 80161 AATTAGGCTT CTTTGAGTAT ATGTTTATAT ATAGTTTTGA CTTTTGAATT ATGTTTATGT 80221 TTACATAGTC AAAAATATAA ATTAATCAAC AGAAATAACA AAAAAAGAAG AAATCACAAG 80281 CTTTAAAATT TAATACAAAC AGAAATAATT GAATCTAACA GTATATCAAA GTGATAACGT 80341 AAACTCAGAA GAAAAAAACA TAATCCAACA TACCAGTGGA ACACAATATT CTAACTGTAT 80401 ACATTCAGTG GTTATAGTCT AAGGACAAGA AAAATTGCAA AAATATCTTG AACTTTAGCT 80461 TGTAGGATTT TTATTGGTAG CAATACTAAT GTACTAATTC TGAAATTAAT GTTCGTGTAT 80521 TATAGAATTG AGTAAATGAA TAAATATGTT GATGTTATTG GGAACTAAAA TTATCATTCT 80581 GGGAGTAGAG AAATATAAAT ATGGACTTGG CAAATGAAAC AAAGACCTGC AGAGAGATAA 80641 CCATATAAAC TCATTATTTT AAAAATTATA AGTGTCCTAG CTCTGTTACT GAAAAGGCCT 80701 AGATTCAATC TTATCTTGAT AGACAGGAGG GCACCCCTTT CTCAGAACAT GGTTTCCAAA 80761 TGCCATTCTC CATTAAAAGG AACAAGGTCT TCTTGGAGAA AAGACTGATT CTAGGTCTGG 80821 ATTAGGTAAA GTACAACGTT AGTCTGGAAT TTCTTGCTGA ATCAGAAGTA AGAAAGTGCT 80881 CAAAAACATG GGAACATGTC ACAAACACAC GTGAGGCAAC TTGAATCCTC ACTGGCCATA 80941 TTTAGGACAA TCGAGCATCA AAAAAAAAAA AAATGTTGAG AATAATGGAT TCTAACACTT 81001 AAAACAAAAA ATAATCCATA GCCCACAGAA GGGGAAGAGA GGGGGAGCTC TTATTTACAG 81061 ATGAATATCA AATAGCAAAG ACAGAAGAAA TGACAGAATT AGAGAAACAT CATTTTGCAA 81121 AACACCACTG TAATAATCAA TTCAGGCAAG TATTATTAAT GGATGTATTA CTATTGCGTA 81181 AAACCAGTTG GGGAACAGGA TATTCATACA GTCTGAAGGT GTCACCCTAA ACATAACTTA 81241 TTACAAGTGG AAAATGGTGC CTTTACAATG AAGAAATCTA GCAGAAACCA TCTTAATCTA 81301 GTGATCAAAC TTAGTATCAC CAATAATGGA TCATACTGAG TCATGTGTCT CCTAATATGA 81361 TGCACCAGGA AGGATGCAAC GTCATGAACG TTGTATTCTT TTGTATTCAA CAGACCACCC 81421 AGGGTAAAGG CAGCTTTCTC ACTTACTAAT CAGAATTGTT GGTTTTAATT CATTTTGGAT 81481 TTTAAGATTT CTTACTTTCT TGTCAGCTCA GAAATTTATT TAAGATGATT TTTATCTTTT 81541 ATTCAATACT TTAGCTTGGA GAACCATTCA GAGTTTCTAA CTCATTGTAT TGCCAAAAAT 81601 AGAAAACAGC ATGGTTTCTT TTGAAAATGT CTAACTTTAA AGTTACTTGT GTGTGTCACT 81661 CAGATTCACA TAGCTTTTTT GCCTAGTAAT GTAGTATCAT GTGGCAAGGC TATAAAAATG 81721 TTTACAATCT TTTATTTAAT ATGACTCTTG AGAGTTTATT CTAAGGAAAT AATTGAATAG 81781 TAACAAAACA CTATTAACAC AAAGCATAGC AATTTGATTT GGGCAACCAA ACACTGGAAA 81841 CAACCTAAAT GTCCATTACA GGAATCATTT ATGAAGCAAA CACTAAAATA TTTATTGTGA 81901 AGATTATGAG AACATAGAAG ACAGTTATGA GAGTAAATTT GAAAACCTGA ACACAAAACT 81961 TACATATACT CCAATTGTAA CTTATAAAAA ATACGTGCAT ATAAGGATAA AACAGTACAA 82021 ACAAAAAAAT AGTTGCGTTA GATTGGTAGA ATTATGGCTC CTTTTGCTGT CTTAATTTTT 82081 TCCTTTTACA TTTTGATACA TTATTTTAAT TTTAATTTTA AAATTCAAAA GAATTTGCCA 82141 CTCATCTTTG CCACTTCAAG GAAAAAAGAA ATGTGTTCGA TTATTCTGTT CTTAGTATAG 82201 TTTTGGCAAT TTCCTCACGT GTAAAAAGAG AATACTATTA ATAATTTCAG TATCTATAAG 82261 ACAATATAAA ATTAAAGAAT CTAGCCCAGT AACTGGTACA TGGAACGTAA TTAATAAATC 82321 ATTATGGACT TTTTTTCTCA CACCCAAGTA GGGAGGAATC AGTGGTCCCC TAGAGGCCCA 82381 GTGTAGAGGT GGCAGCACCA ATCCCTAGGG GAGAAGATCT TGGTGATGAT AATTCCTGAG 82441 CAGACAGTTA GCTGAGAATT CAAGAGCAGA AAAGTAAGAA AGAAACAACT TCTTGCTAAC 82501 ACCTTTCCAC CCACGTTTCC CTGTTCTGTT GTACTCTGCT TACCCTTTCA TGGATGGAGG 82561 CAGAGGAAAG AGAACCAAGT TTGCTCTTAG TCATTCACTA TGTTGTTTAA TCTGCCTTCC EPI-109 632

82621 ATCTTTCTTA TCAGTTCAAA TTAGAATGTA GACCTGAATT TAAATCL b TTCTGTCAGT 82681 TATAATGTGA CCCTAGACAA AACACATTCT CTGAACCTCA GAGAACATTC TTCATTTGTA

82741 GAATGGGAAG ATTAATCTAT ATTCCACTTG GATGGCAAGT CTTTTATAAA CTTTATAACC 82801 TAAACATGTG TGAGTTGCTA GTATCATTAT GTTGGTAAAG TTATTCTGAG ATATGATAAC

82861 AGAACTGTTT TGTCTAACTC CACTAGCATG GTTCAGGTTT AGAGAGTGTG GAATTAAAAG 82921 GCTTTATCCT CAAATATGAC TTAAATCCGA TTTTTCTCAT CCACTTTCCT CCACAAACAA 82981 ATCCTCAGGA AATGACAAAC TTTACATGGT TAAACATCAG TTTTGTTTAG TCTTTGACAT 83041 CCACATGGTT AAATCATACA TTTGAAAACT GCTTATATTT GTGTTGTCTA TGTCTAAATT 83101 GAAAAGACTT ATTGAGGAAT AGAAGACTAC ACATTTTTCA GCAAACACTG CACGTTTTGC 83161 AGAATTTCCC CAGGCACCAG TCTCCAGGAA TTTATTGGCT ACTAACAATA CTAAGATATG 83221 GATGAATGAG GAAATCAAAA TGGAGATCTT GCAAGTTTTG TGAGAATGGG TGAATGGTCC 83281 AAATGAAGAG ATAAGTTGTG AAATATTAGT ACAAGTAAAA ATTATTTACA ATGAAAGACA 83341 TTTTGTCAAT AGCTATGAGA ATTTTACCAT TGACCCAGAA ATTCCATTTC TTTCTTCAGA 83401 AATACCCACG TAGGTATACA TATAAAAAGT TATTCATTAC AGTATCGTTT TTCATAGGAA 83461 AAAGTTTTAA AAATCAGAAG CTATCTAAAC TATGGTATAT CTAGGTCATA GAAATCAAAT 83521 GACTAAAAAT GTTAATATAA GCATATGTTT TTAAATTAAC TTGGCTTGGG TCTTCAGCAA 83581 AATTGGCTTC TTAACATTGC ACTCCAGAGT TAGACTTACC CACTCAGTCA CTTATCATGC 83641 AGGAGCAGAC TCCTAATACC ACATATCATA GAGCAGAGTA GGACACAGGT TCTCTGCAGG 83701 CAGGCAAATC CCAAAGAGAA GGGAGGAAAG GGCTGAGACA CTGCATGGTC AATTTCTTCT 83761 GAACTCTGCA ATGTACGGAG GTGGACAGTG TCCACAAAGA TTGCTCCCCT GGACCCACCA 83821 TCATAATAAC ACAACGGCTT TGTTTTGTTT TTGTTTTTGT TTTTTGACAC GGAGTTTTGC 83881 TCTTGTTGTC CAGGCTGGAG TGCAATGGTG TGATCTCGAC TCACCACAAC CTCCACTTCC 83941 TGGGTTCAAG TGATTCTCCT GCCTCAGCCT CCTGAGTGGA TGGGATTACA GGCATGCACC 84001 ACCATGCCCA GCTAATTTTG TATTTTTAGT AGAGACGAGG TTTCTCCACG TTGGCCAGGC 84061 TGGTCTCAAA CTCTTAACCT CAGGTGATCC ACCCGTCTTG GCCTCCCAAA GTGCTGCGAT 84121 TACAGGTGTG AGCCACCGCG CCCAGCCCAC AATGGCCTTT TGTTTACATC TCTAGTGCAG 84181 CACTCATTTC ATGTTCTTTC AAGAAGAATA CATATTTCAT CTTTTTATTT TATACAGCAA 842 1 TTAGCACAGT GCCTGGCATA AGGAAAATGA TCATTAAAAG CTGGGTGAAA AACCTAATAA 84301 AGCTACTGAG GATAGGAACT GCAGACCAGC ATGGAAAGAA AACTATGAGC CAGATATTGA 84361 CATCATCCTG AAAGGCAGAA GATTTAGTAT AGGCAAGAAG TATGCTTTTG GAATATAGAA 84421 AATCTGGATT ATGATAAGAA AAGAATCATA TTTGTCTTAT CTTACCTACT CACTTCTCAG 84481 TTCCACATGT TTCTGAGGCT GTTTGTCCTT ACTTTCTTTT CTGTTTTATC CACTCTTTCT 84541 GTTCTTTAGA TTGGATCATT CCTATTGAGC TGACATCAAG TTAACTGACC TTTTATTTTG 84601 TCCAAACTGC TGTTAAATGC ATCCAGTGAA TTTTTAACTT TATATAGTAT ATCTTTTAGT 84661 CCTAGAATTT CCACATGAGT TTTTTAAGTT TCCATTTCTC TGCTGAGATC TCCTATTTGT 84721 TCATTCATTA TGACCATATT TTTCTCTACA TTATTGAGCA TAATTATAAC AGCTCTTCTA 84781 AAATTCTTGT CTGCACATTC TAACACCTGA ATTATTCTGG GGTCAGTCTC TGTTACATTG 84841 CCTTATTACA AAAACAGTAT AAGTCACATT GCCTTGTTTC TTAATATGCA AAATGATTTT 84901 TGATTGCAGA CTAGACATTT TGAATTAAAC ATTATAGAGA TTCTGGATTC TCGAGAGAGT 84961 ATTGACTTGT TTTTTCCATC AGGCAGGTAA CTTGACTGGA CTCAAACTCC AAACTCTAGG 85021 TCCTCTGTAA TGGGCAACTG CAGTAATCTT TGTTTAGTTC TTTAAGACTT ATTGGCCAGG 85081 CACGGGGGCT CATGCCTGCA ATCCCAGCAC TGTGGGAGGC CAAGGTGGGA GGATCACCTG 85141 AGGTCAGGAG TTCGAGACCA GCCTGGCCCA CATGGTGAAA CCCTGCCTCT ACTAAAAATA 85201 CAAAAATTAG CCGGGTGTGG TGGTGGGCGC CTGTAGTCCC AGCTACTCAG AAGGCTAAGG 85261 CAGAAGAATC ACTTGAACCT GGAAGGCAGA GGTTGCAGTG AGCCGAGATT GTGCCACTAT 85321 ACTCCAGCCT GGGTGACAAA AGCGAGACTC CCTCTCAAAA AAAAATTTAT TGGCACTGCT 85381 TGGCATCTGC TATGAATACA TGAAGTTCAT GGGTCAGCTA TAGATCTGGG CACGTTATAC 85441 ACAGAATTTG GGTCTCCCTT TCTCTGGATT TCTCCTTTTC TGGATTTCTT TTCTCATTTT 85501 CCAGCAGCTG TGGTTGCCCT AAACTCGGTC CTCTGTTTCT TTACGGCAGT AAGATTTGGG 85561 AACTTTTAGG TTTTACCTGC CTCTCAGACA AAATAAAAAA TAATTTTCAT CTTGATGCTA 85621 CTCCTTTCTT CCAGATGTAG ACACCTCTCT AATTTCCAGT TGCTTTTTAT TGCTCTCCAG 85681 AGTCTAAAGA TTATCATTGT TTTCTGTGGG AGAGTTGGTC TGATAAAAAC TACTCCCCCA 85741 AAACTGGAAG CTGGAAGCTT GTAATTATGA ATAGACTTTG AGTAGTATTC TTCTTTGGAA 85801 AAGGATTTTA ACTACTCCCT ATGTACTTCT TTATTTCCTG TTTTTCTCAT CCGTAATCTT 85861 TTTATTTTCA TACTTCCTAA GTCAGACAAT TTTCCTACTT GAAGATTCAG TGACTGCTAT 85921 CAAATGACCC CCATATTACT AAATACAATA TCCCCAACTG CATTTATAAA AAGAAAATTT 85981 ACTGTTTATT AGTAAACAAT GTTGTAGAAT AGTAAAATAT TGCTGGGCTT TGGAGCCAGA 86041 TAATCAAGGT TAGAATCCCA GATTCTAACT TACTAGCTGG TGTATTAGTC CTTTCTCATG 86101 CTGCTAATAA AGACATACCC CAGACTGGGA GACTGGGTAA TTTATGAAGA AAAGAGGTTT 86161 AATTGACTCA CAGTTCAGCA TGGCTGGGGA GGCCTTAGGA AACTTACAGT CATGGTGGCA 86221 GCAAGGAGAA GTTCCAAGCA AAGAGGGAAA AGCCCCTTAT AAAACCATCT GATCTTATGA 86281 GAACTCACTC ACTATCACGA GAACAGCATG AGGGTAACTG CCCTCACGTT TAATTACCTT 86341 CCACCAGTTC CCCCCCATGA CACATGGGGA TTATGAAAGC TATAATTCAA GATGAGATTT 86401 GGGTGGAGAA ATAGCCAAAC CATATAATTC CACCCCTGGC CCCTCTCAAA TCTCATGTCC 86461 TCACATTTCA AAACTCAATC ATGCCCTCCC AACTGTCCCC CAAGGTCTTA ACTCATTCCA 86521 GCATTAAGTC AAAAATCCAA GTTCAAAGTC TCATCTGAGA CAAGGCAAGT CCCTTCTGCC 86581 TATGAGCCTA TAAAATCAAA AGCATGTTAG TTACTTCCTA GATACAGTGG GGGTACAGGC 86641 GTTGGGTAAA TACACTGATT CCAAATGGGA GAAATTGCCA AAACAAAAGA GTTACAGACC 86701 CCATGCAAGT CCAAAACCCA ATAGGGCAGT CATTAACATT AAAGTTCCAA AATGATCTCC 86761 TTTGACTTCA TGTCTCACAT CCAGGTCACA CTGATGCAAG AGGTGGGCTT CCAATGGCCT 86821 TGGGCAGCTC TGCCCCTGTG GCTTTGCAGG GTATAGCCTG CTTCCTGTTT GCTTTTTCAC 86881 AGGCTGACAT TGAGTGTCTG TGGCTTTTCC ATGAGTATGG TGCAAGCTGT TGGTGGATTT 86941 ACCATTCTGG GGTCTGGGCC AGGTGCAGTG GCTCATGCCT GTAATCCCAG CACTTTGGGA 87001 GGCTGAGGTG GGGGATCACA AGGTCAGGAG ATCGAGACCA TCCTGGCTAA CACGGTAAAA 87061 CCCAGTCTCT GCTTAAAAAA TACAAAAAAT TAGCCAGGCG TGGTGGTGGG TGCCTGTAGT EPI-109 633

87121 CCCAGATACT TGGGAGGCTG AGGCAGGAGA ATGGCGTGAA CCCAG.-7.._■>_^■- ι-.ι-Λfc7CTTGCA 87181 GCGAGCTGAG ATTGTGCCAC TGCACTCCAG CCTGGGCGAC AGAGCAAGAC TCCATCAAAA 87241 AAAAAAACAA AAAAACCATT CTGGGGTCTG GAGAATGGTA GCCCTTACAG CACCACCAGG 87301 CAGTGCCCCA GTGGGGACTC TGTGTGGGGG CTCTGACCCC ACATTTCCCT TCTGCACGGC 87361 CCTAGTAGAG GTTCTCCATG AGGGTTCTAC CCCTGCAGCA AACTTCTGCC TGGACATCCA 87421 GGCATTTCCA TACATCCTCG GAAATCTAAG CCGCGGAGGT TCCCAAACTT CAATTCTTGA 87481 CTCCTGTGCA CCCACAGGCT CAATACCACA TGTAAGCCAC CAATGCTTGG TCAGGGCTTG 87541 AACCCTCTGA AGCAATGGCC TGAGCTGTAC GTTGACACCT TTTAGCCTAG ACATCTAGGA 87601 CACAGGGCAC CATGACCCGA AGCTTCATAA AGTGGGAGGG CCTTGGGACT AGCTGAGGAA 87661 ACCATTTTTC CATCCTAGGC CTCCAGGCCT GTGATGGGAA GGGCAGCCAT GAAGGTGCCT 87721 GACATGCCCT GGAGACGTTT TCCCCATTGT CTTGGTAACT AACATTCAGC TCCGTGTGCA 87781 GCACCAACTT ACTTATGCAA ATTTCTGTCA CTGGTTTGAA TTTCTCCCCA GAAAACAGGA 87841 TTTTTCTTTT CTATTGCATC ATCATGCTGC AAATTTTCAA ACTTTTATGC TATGCTTCCT 87901 GTTGAAGACT TTGCGGCTTA GAAATTTCTT CCCCCAGATA CCCAAAATTA TCTCTCTCAA

87961 GTTCAAAGTT CCACAGATAT CTAGGGGACA AAATGTTGCC AGTCTCTTTG CATAGCAAGA 88021 GTGACCTTTA CTCCAGTTCC CAACAAGTTT CTCATCTCCA TATGAGACCA TCTCAGCTTG 88081 GACTTAGTTG TCCATGTTAC TATCAACATT TTGGTCAAAG CCATTCAACA AGTCTCTATG 88141 AAGTTTCAAA CTTCCCCATG TTTTCCTGTC TTCTAATAGC CCTCCAAATT TTTCCAACCT 88201 CTGTCTGTTA CCCAGTTCTA AAGTCACTTC TACATTTTTG GGTATCTTTA CAGCAGTGGC 88261 ACTCCCCATG GTACTAATTT ACTGTATTAG TCTGTTCTCA TGCTGCTAAT AAAGACTTAC 88321 TCGAGACTGG GTAATTTATA AAGAACAGAG GTTCAACTGG CTCACAGTTC AGCATGGCTG 88381 GGAGGCCTCA GGAAACTTAC AAACATGGTG GCAGCAAAGA GAAGTTCCAA GCAAAGAGGG 88441 AAAAGCCCCT TATAAAACCA TCAGATCTTG TGAGAATTCA CTATCATGAA AATAGCATGA 88501 GGGTAACTGC CCCCATGATT AATTTACCTC CCACAGGGTC CCTCCCATGA CAGGTGGGGA 88561 TTATGGGAAC TACAATTCAA GATGAGATTT GGGTGGGGAC ACAGCCATAC CATGCCAGCT

88621 AGAGAGCCTT AAGAAAGTCA CCTAATCTCC ACAAATAAAA GGTTTCCTAT TTGTTCAACA 88681 AAAATAATGA CACCCCTTTT ATGGGATTTC TGTGAGGACA AATGATAACT AACATAGCCT 88741 TGCATAGTGT CTGGCACAAA ATAGCTACTC AAAAAATAAT AGAAACAACA TTTAAAAAAT 88801 GTAGACTTTA TTTTTTAGAG TTTTATGTAC AAAGCAAAAT TGAGCAGAAT GTACAGAGAG 88861 TTTCCGTATA GCACTCCCTA CCCCCAAGCA CAGATAGCCT CCCCCAGTAT CAGCATCCCG 88921 CACCAGAGTG GTACATTTAT TATAACTGAT GAATCTATAT TGACGTGTCA TTTTCATCCA 88981 AAATCCATAG TTTATATTAG GGATGCCTCT TGGTGTTGTA CCTTCTATGG GTTTTGACAA 89041 ATGTATAATG ACATGTATTC ACCATTACAG TATCATAAAG AATAGTTTCA CTGTCCTAAA 89101 AATCTTTGAT CTTCTTCCTA TTCATCACTC CCTCCCCATT AATCCCTGAC AACTACTGCT 89161 AATTTTCCTG TCTCCATTGT TTTGTCTTTT CCTGAATGTC ATATAGTTTA AATATACAGT 89221 ATGTAGGATT TTCAAACTGG TTTATTTCAC TTAGTAATAT GCATTTGATG TTCTTCCATA 89281 TCTTTTCAAA GCTTCATAGT TCAATATTTA TAGAATTGAA TAATATTCCA TTGTCTGGAT 89341 GTACTACAGT TTATGTATTC ATTCACCTAT CAAAGAACAC CTTGGTTGCT TCCAAGTTTC 89401 AACAATCATG AGTAAAGCTG CTATAAACAT CTATGTACAT GTTTTTTTGT GAATTGAACA 89461 TTTTCAGCTT TTTTAGCTCC ATTCCTAGGA GTGCAATTGC TGGATTGTAT GATAAGGGTA 89521 TGTTTAGTGT TGTAAGAAAC TGCCACGCTC TTCCTAACTG GATGTACTGT TTTGCATTCT 89581 CACCAGCAAT GAAAGAGTTC CTGTTGCTCC ACATACTCAC CAGCATTTGG TGTCGTCAAT 89641 GTTTTGAGCA ATAGCATTTT GATCTAACTT TTCCTAGGTA TTCTTTTTGA AGGAAATAAT 89701 ATGACAGATA ATAGAGAAAG GATATACGAG GACAGTTCTG TCCTTTATTT ATAGTCCATC 89761 ATTTAATGAA GGACTCTGTC CACACTTGGT ATTTTTAACT CTGATCCTCC TCTCCCATGA 89821 ACTCTGACAA TCTCCTAAAT CCCTGTTGCT GGCACACATG GTTGTGTATC AGGCCCCCTG 89881 TGGTCTGTCT GAAGCATGGC TTTTTTTTTT TTTTTTTTTT TTTTTTTGAG ACGGAGTCTC 89941 GCTCTGTCGC CCAGGCTGGA GTGCAGTGGC GCGATCTCGG CTCACTGCAA GCTCCGCCTC 90001 CCGGGTTCAC GCCATTCTCC TGCCTCAGCC TCCCGAGTAG CTGGGACTAC AGGCGCCCGC 90061 CACCACGCCT GGCTAATTTT TTGTATTTTT AGTAGAGGCG GGGTTTCACT GTGTTAGCCA 90121 GGATGGTCTC GATCTCCTGA CCTTGTGATC CGCCCGCCTC TGCCTCCCAA AGTGCTGGGA 90181 TTACAGGCGT GAGCCACCGC GCCCGGCCTT TTTTTTTTTT TTTTTTTTTT TTTGAGATGG 90241 AGTCTGTCAC TCTGTCACCC AGGCTGGTGC AGTGATGCAA TCTTGGCTCA CTACAACCTC 90301 CATCTTTCAG GTTCAAGTGA TTCTGCCACC TCAGCCTCCC AAGTACCTGG GATTACAGGT 90361 GCCCGCCACC ACACCCAGCT ATTTTTTTGT ATTTTTAGTA GAGACGTAGT TTCACCATGT 90421 TGGCCAGGCT GGTCTCATTC CTGACCTTGA GTGATCCACC TGCCTTGGCC TCCCAAAGTG 90481 CTGGGATTAC AGGCATGGGT CATCACATGT GGCCTGAAGC ATGACTGTTG CTTTAATCAT 90541 ATGAAATACT GCTCTGTATT GTTATCTATT TGAAATGCCA CACCTCCTGA GCTAAATTGC 90601 AAGCTTTTAT GGAGCACAAA CCATATTTAT ATATATTAGC ATGATACCAT GACACATATC 90661 AAAAGCTGTT ATATATTGTT ACGTGAATTG ATTCTTTCTC AGTTAAGAGG ACCTCTGTAG 90721 TAGCACTTTC ATACCGTTAA TTTTTCATTT TGTGCCCAGC CCCTACTCTG TGAAAAATGA 90781 AATGAATCCT GTTATCATTT CCCTCCCAGG CCTTTTCTCC TTGTGGACAA TGTGTGGCTC 90841 AAGAGAAAAT TCAGTCAGTA AATTTGTTCA GTGCACAAAC TCTTTATCAC CTCTCACTGT 90901 TCTCAAGTGA GATAGAACAG AACATCCATC CAGTGTCTTA CAAATTGTCT GGTATATAGT 90961 AGGCACTCAA TAAATGTTTT TTGAATAAAT GCATACATGA ATCCTATTCC TATATATAGT 91021 ATGGTAGACA GATCATTGAT ACCCAAAGAT GCCCAAATGC TGATCCCCAG AACTTGTGAA 91081 TATGTTACAT TTCATGTCAA AAGGGACTTT GCTAATGTGA TTAAGGATTC AGACCCTTGG 91141 ATTGTAAGAT TATCCCGGAT TAACCAGGGC CAATCTAATC ACATGAGACC TTAAAAAAGC 91201 AGAAAACATT TCCCAGCTGG GTTAGAGAGA GATGAGACAG AGTAAAAAGG AAAGAGATTC 91261 AGGGCATGAA AATGACTCTA CCCACTGTTG CTGGCTTTGA AGATAGAGGA ACTAGGCCAC 91321 AAAACAAGGA GTATGAGTGG CCTTAAGAAA TAGGAAAAAG CCCTCATCTG ACAGCCAGCT 91381 AGAAAGCAGT CCTCTGACCA CAAGAAATTG GATTCTGCCA ACCACTCAAA TGAGCAAGGA 91441 AATGGATTCT CCCCTAGAAC CTCCAGAAAG GAACACAGCT CTGTAATGCC TTGATTTTAG 91501 CCAGGTGAGA CCTGTTTCAG ACTTTTGACC TATGGAAATA TAAGATAATA AAGTTTTATT 91561 GTATGCTGCT AAATTTGCGG TAGTTTATTA CTGAAGCAAT GGAAAGCCAA TACAGACAGA

91621 ATATACAGAG AGAAAGAGAA TGAGTTCTTT CCTGATAATT TGTAAΛ...-. IUU-IUΪCA 91681 CTGGACAAGC TTCACAGAGG ATTCACTGGT TCCCTAGCAA ACCAGCATGT CCAGTCCTGC 91741 AGCCTCCCTT TCTTAGGCCC AGCATATGTC AGCTGTGTGC ATAGAAAAAT CAAAGCAGGA 91801 CCCTGAGTAG TTGGAAAGAA AAGATGGTTG GAAATGGGTT GCACTTCAAG TGAGGAAACA 91861 AGAGGTAGGA GACCGGCATC TCTTTCTCAT ATGTCCCAGG CTGACTCTTG TGAGTTGTTT 91921 TCCCTTGGAG GCTATCGATG ACAGTCACAG TAACCTGATG GAACCTGGAT CATGATGAAA 91981 GAAGTAAGTG TCAATGGCTC CGACTTCCAA GGACTCTGAT GTCCCACAGC ACTAGCTAAA 92041 CAAAGCCAGT TGGAAATGAG CTTAAATGGG GAATTTCCTG AATATATTCC CTATTGTTAG 92101 GAAGCCAGGT TGGCTTCCTT GCCTACAATT ATGCCAAGCA GTCACACTAT AGAGTCCCTA 92161 GGGACATGAT ATTAAGTGAT TCTTTTAACA CAAACAACTT AATAATCATT TATACTAATA 92221 GCAAAACGGC CAACGGCTGA TATTCCACTT GAAGTAGAAT TGGCTATCCA ACTGGAAGAG 92281 AAGACAGGAA GACGTGATCT CCAGGGAGCC ACTAAAAGGA TTGGCACCTG CCTCTGGATT 92341 CCCCTTTTCC TTATATTACC TCTCAGCACT GGCAGGCCTT TATTTCAGGA TACAGTTTCA 92401 CAAGTATTAT GTCACGTCTC TGAGAATTAT GTTGGTAGAT ATTTGCTCCT CTGGCCAGAA 92461 AGACCTAGTT TGGAGTCTGG AGTCATGAAG GTGACATACA TGTAGCTAGT GACATAAGTG 92521 TAGCTAGTAA AAATAGTGAG TAATGGCCCT GAAATTCTAT TGAATGCCCA AAGTGCTGAC 92581 CAGGAACAAG CATGCTCTAG CTTATCTCAC AAGGAACTTG ACAATTTTCT TCAAAAATCC 92641 TAGTAGCTAA GATTTCTTAG TAACAAAGCC ACTAAGGCAC AATTATGATT AACTTGACCC 92701 TTAGGTGACT TTTAAGGACT ATTCTATAAA ATATTACAAC TAATAGTGGA TCCAAGCCAG 92761 CACACTCTGC TATATAAGAT TAATTGACAG TGTCCACACT GGTAAAATAA GTTGTTTCAT 92821 AAATACATTA GAATTCATTT GCACTTTCTA CACAGCCCCA AGTCCAGAAC TTTCCCCAGA 92881 ATAGGTCTAT GTTTTGCAAT CTGCTACTCC ATACAGAGAT TTGAGTTCAC TTGGCAATTT 92941 AGTGCTGCTT ATATGTGACC AGTTAGTCTG TTTTACTTAT CTATGCCTTA AACATTACTA 93001 TACTTACTAA CTCCAAGATG CCTGGTCTCA ACTTGACAAA AATACCCCAA GTTGGGAAAT 93061 CCTTATGTGA ATATGTAGAT AGTCACAATT GCTGGTTGAT GATGATCTGT CTTTTCCTGT 93121 ATTTGAGAAA ATGGAGATAA AATGGACCAA TCCAAATAAT GGATTAAACA TGGGAATAGG 93181 TGAGAGAGAG AGAGGAATAC ATGGTGGCTC TCAGTGTCTG GCTTAGGCAG TAAACACTTT 93241 CGTTAATAAA GACGGAAAAT AAAAAAGGAA TAATTGGTGT CTAGGGGAAA ATAATGAGCT 93301 CAAGTTTTAA CACTCTGAGT TCCCGGATGT GAGACATCCA GGCGCATTTA TCCAAGAGGC 93361 AGTTGGAAGC AACGTTCCGG AGCTTAGGAG AGAGGCATGA CCAAAAGCTG GTGGGACTGT 93421 GAAAAGGTAT GGCCATTCTG GAAAACTGTT TGGCAGTTTC TTAGAAAATT AAACATGTAC 93481 TAACAACCCA GCAATTGTAC TCTTGAGCAT TTGTCCCAGA TAAATGAAAA AAAAAAAAAG 93541 CATTTTTTTT ACACAAAAAC ATATACATGA AAGTTCATAG AAGTGTTATT CATAAAAAAC 93601 TGGAAAAAAC TGAGATGTCT TTATTGAGTG AATGCTTAGG CAAACGGTGG TCTATCCATA 93661 CAATGGAATT ATGCTTAGCA ATAAAGAGAA AAGAACTATT GATACATGCA ATAACACAGA 93721 TGAATCTCAA AGGAATTAAT GCTGAGTGGG AAAAAAAGCA CATCTCAAAA TGGTATATAC 93781 TGTACTATTT TATTTACTTA ACATTTTAAA AATAGCAAAA TCATAGAGAT GGAGAACAGA 93841 TTAATGGGTA CTGTGTTTTG GGATGGGGAG TGAGAAAAGG GTAAGGTGTA AATATAAAGG 93901 GGTAGCACAA AAGAGCCTTG TGGTTGAAGG ATTCTATGTC TTGGTTGTAG TCGTGATTGC 93961 AGGAATCTAC ATGTGATAAA ATTGTATGGG TCTACATACG CATACACACA AGAGCATATA 94021 AAACTGGTGA CATGTGAAGA AGCTCCGCAC ATTGTGCCAA CATCAGTATC CTAGTTTCAA 94081 TATCAGACTA CAGTTATACA AAACATTGTC ATTGAGGGAA ACTGGGTAAA GGGAACACAG 94141 GACATTTGGC ATATATTTTT GCAATTTCCT GTGAATCCGT AATTATTTAA AAATAACAGA 94201 TATACTACAT ATCAAAAATT TAATGTCATA AAGTTGATGA GTTTACCTAG TGGATAGCTT 94261 TGTTAATATC TGCTATAAGA CTACTGAAAA TGACAGTTAT GCAAGTATAA GCTCAGAGAA 94321 CTTTCCTCCC CCTTCGTAAA TGAAATGAGC AAAAGAAATG AAACAGGAAA GGCAAGCAGT 94381 ACTGAAAACA GGGAAGGGCT CTTCCCCATA TAACTATATC TGCGACTTCA ACAGCTATTC 94441 ATCCAGAAAC ACAGCCTCTT GCGCTAAGAG GAAACTTTGG ATAACAATAT GTTTTCACTC 94501 TCCAAGAGAG AAAATGGATA GATTAATTTT TAAGAAAAAA AAAAAAACCT CACCAATTTC 94561 ATGCTGTGGC TTGCACCTTT AATCCCAGCT ACCTACAAGG CTGAGGTGAG AGGCTTACTT 94621 GAGCCCAGGA GTTCAAGGCT GCAATGAGCT ATGATTGATT GTGCTATCGC ACTCCAACCT 94681 GGAGTACTAA GCTAAGAGCT AAGAACACAG CTGAGAGCGG AGAAGAAACA AACAAATCTG 94741 ACCAATAACC CCCACTCCCC TCATTTTACT GGAGTGAGCT GAGACTGCTG GCAAACATGG 94801 CCTTTGACCT AGCCTGAACT GTAGCAAAAG TCATCAGATA TTTTTCCACC AATCAACAGA 94861 CAGAAGTGGG GAGAAAACAA TCGTAGTTCA TAACTACAAC AAGCAGATAA ACGAAGGCCA 94921 TGGTGAGGGA TGGAAGACAT TGTGATATAT CAAAGGCAGG CTCATTTAAA ACTCAACCCA 94981 AATTCCAAAC AAAATATATA ATTGAATATG TATTAATGCC AAAGGAGCTT GAGTGAGCTT 95041 TAGCACAAAC CCCGCCCTCC AGCCCCCACC CAAAAAAATC ACTCTGTTCT CTCCCCATTC 95101 TTTGATAGGC ATACTTGCTG TTTTCTCACA GCCAAGGTAC AGAGGGGACT TAGAGGAACT 95161 AGAACTCTAA TACACTGCTA GCAGGAATGT AAAATGAAGC ATCTACTTCA GAAAACCATT 95221 TTATCAGTTT CTAGAAAGTT AAACATAGAC CCACCATGCA GCCCAGCCAC TCTACTCCTA 95281 AGTATTTACA CAAGAGAAAT GAAAACGTGT CCCCACACAG TTGTATTTAA AGGTGATGGT 95341 TAGCCTTGTG TGTCAACTTG GCTAGGCTAT AATACCCAGT TACTGAATCA AATAGTAATC 95401 TAGGTGCATC TGTGAAGGTA TTTTGTAGAT GTGGTTAACA GCTACAATCT GTTGACTTCA 95461 AGTAAAGGAG ATTGCTCTTG ATAGTATGGG TGGGCTTCAT CCAATCAATT GAAGGCCTTA 95521 AGAGCAAAAA GTAAGGTTTC CCGGAGAGAA AGAAATTCTG CCTCAAGACT GCAGCCTCAA 95581 CTCCTGCCTG AGTTTCCAGT CAGCCAGCCA GCCTAAAGAT TTGCTAGGCA TTATAATCAC 95641 ATCAGCTAAT TTCTTAAAAT AAACCTCTTT ATATATATTG ATACAATGAA TGGTTATAGC 95701 AGCCTTATTT GTAATAGCCA CAAACTGGAA ACAACCTAAA TGTCCTTCAA TAAGTGAATA 95761 CATAAACAAA TTGTGGTATA TCCACAATTT TTACGCAGCA GTAAAAAGGA ATAAATGGTT 95821 GAATAAGGAA TAAACACATA ACAAGGATGA ACCTTAAAAC CGTAAGGCTG AATGGAAAAA 95881 GTCAGACAAA ACTAATACAT ACTGAATAAT TCCATTTATA TTGAAGTTCT AGAAAATGAG 95941 GACTAACCTA TAGTAACAAA AAGCAGAAAA ATTTTGCCCA CTGGTGATGG AGGGGGCGCA 96001 GGTATTGTAG AGTATCTGAG AAAGGACAAC TGGATAAAAG GGGGCACAAG AAAACTTTTG 96061 AGGGTGATTG ATATGTTCAT TATCTTGTGG CATGGTTTCA TAGGTGCATA CATATGTCAA EPI-109 635

96121 AACATCAAGT TATACACTTT TAAAATGTTC AGTTTACTGT ATATCTAΓTA TACTTCAGTA 96181 GAGAGGAAGG AAGAAAGTGG GCAGGGTGGG GGAGAGGAAA GGAAACGAGG GAGGAAAGGC 96241 CCTAATAGGA AGGATTTTGG AGTTTAGATT TTAAAATGAT AAAGGATGTT TGACACTCTA 96301 GGCATATGAC GAATATAGGA TTATGAGTCC ACAAAAACCA CCAGGAAGTC ATGTATGTTT 96361 ATACTTTTAA GTGAAGGATC AGTGGATTAT CAACTCCCTA ATGCTTTGCC TCTCTATGAC 96421 TGGCTGCTGT CCTTCTCATC CCAATACTCC TTCCAAAGCC CCTTGCTTAA ATGTAAGCCT 96481 TCTTTCCTCC TTTCAACACA TCCTGCATTC CGTGACAAAA TAAGTTTTCC TTAAACAGAA 96541 TGTACAGCAT ATTATTTGTA CAATTAAAAA TTTTTGGCCA GGTGTGATGA CTCATGCCTG 96601 TAATCCCAGC AATTTGGGAG GCCGAGATGT GTGGATTACC TGAGGTCAGG AGTTCGAGAC 96661 CAGCCTGGCC AACATGGTGA AACCCTGTCT CTACTAAAAA TACAAAAATT AGCTGAGTGT 96721 AGTGTGGCAG GTACCTGTAA TCCCAGCTAC TCAGGAAGCT GAGGCAGGAG AATCGCTTGA 96781 ACCTGGGAGG TGGAGGTTGC TGTGAGCAGA GATCAGACTA TTGCATTCTA GGCTAGGAGA 96841 CAGAGTGAGA CTCGGTCCCC AAAAAAAAAC ACATTTTTTT TTAATGTTTC CTCCTTGCCT 96901 GTAGGAAAAA GGCTCTGACT CCTTAGCCTG GGCATCAGAG CTCTATCTAA ATGGACTTTA 96961 ACCTGATTTT GTGGCACTAA TTCCATTGCA GTACTTGTCC GCTCACTGGC CTGTGCCTCT 97021 CTGCCACTAT TTTTGGAATA ATGTCCTCTC TCCATCTTGT TTACTCAACT ATATCCAACC 97081 TCTAAGGCTG TGCTCCTACA AAGCCTCCCC TGGCTACTTC AGCCCACAGA GATATTTAAC 97141 TGCTCTGCAG TTCAGGACAT TCTTCTGACT CTTTAAATCA CATTTACTTA TATATGATCT 97201 TGTGATATTT TTTGTTGACG TGTTTACTTT AATTTTCTTC CATAACCTAT TCATTCAACA 97261 AACTCAACAA TTATTTATTA AATGCCAAGT TAGAAAAATA TTATTGATTT TATATAGATT 97321 ATAGATATGT TTGAAATTTT ATTTGGCAAT CTGCAAGTAG AAAAATAATT ATAATGTGGT 97381 ATATCTGTGA TAGAAGTATT AGTGCAGAGA CCATGGGGAA CATAATCCAG CCTGGAAGTT 97441 CAGGAGAGAT ACGTGGAAGA AAGGACGTCA GAGCCTTTTT CCTACAGGCA TGGAAGAAAC 97501 ATTAAAAAAA ATTTTTTTTT TTGAGATGGA GTCTCACTCT GTCTCCCAGC CTAGACTGTG 97561 GTGGTGCGAT CTCTGCTCAC TGCAACCTCT GTCTCCCGGG TTCAAGTGAT TCTCCTGCCT 97621 CAGCTTCCCA AGTAGCTGGG ATTACAGGTA CCTGCCACAC ATGGATGATA AATATGATCA 97681 TATTTTCTTG TTCTTTTCCT CCTCAGTTGT CTTCCCTGAA GAAAGGAATG CCTTTTATAG 97741 ATGACAAACT CCCATTCTCA AGAACAAGGA TTTTTGACCA ATTTAATTTA ATCAGATGTC 97801 TGGCTTTGAC CTAGAAACAC AGTCACGAAA CTTGGTGATT AGAGACCAAT TCCCAAACAT 97861 GAGCATTTCT TAGGAAACAC AGTAAAGATC TGAGAGACCC AAGAGCAGAA GGGCGAGAAA 97921 CCAAAAGCCA TCAGTTTGCA TAGGAAACAC CTTGTTTAGC CTAATCTTTT TATTTTTATT 97981 ACTCTATTAG TCACTACAAC TATTTTCTGA TTGCTATGGT GATAGATGGT TTAAAACAAG 98041 CCTTCATTAA GAATTGTCAC ACCATGGTCT CAGTCAAAAA CACCAACATT TTTATTGGTA 98101 TTGACAATTA TGGGAATATC CAATTCCAAG AAGACAAGGA GACCTCTGAA CTTTCTAAAT 98161 GAAGACTCCA ATCTTCCTGA TCTGATGGGA AGCAGCTTGG CAAGATTACC AACCACCACC 98221 ACAGAGAGTG GACTCTAAGC TAAGACTTAA AAGATAAGTA GAAATTATCC AGGTAAAGAT 98281 GTGTACAGAG AAGGAAGTAC ATCCAGGGGA AAAGAACAAT ACGTGCAAAA GTACGGAAAT 98341 GGTAAAAAGT AATACTACAT AGTCAAAGCC AAGCAGAGTT CAGAAGGGAT CTGGTGGTGA 98401 AAAATACGGC TAGAGAAAGC AGCAAGGATT GGCTTCTAAA ACCTATGTAG TATCTTGGAC 98461 CTTACCCTAA ATGTAATGAG AAGCTTCTAA AGAATCTTTC ATTTATTCAT TCATTGAACA 98521 AATATTTTGA GGCTTTCTGT GAAGAACATC ATTCTAAGTA GTAAAGATAC AGCAGTGAAT 98581 AGGACACATA AAATCCTAGA TCTCACAGAA TTGACATTCC AGAGAGGGAA AGGTAGACAA 98641 TAAATACATA AACAAATCAT TTAACAAGAT GATTTCAGAC AATGGTACGT ACTGTGAAAA 98701 AAATGAAACA AGGTAATGGA CAGCGAAAAG GCACTGGAAG GAAGCCTGCT TACCTTTGCA 98761 TGGTTAGAAA AGATCTCTCT AAGAAAGAGA CCACATGTGA GCTGCGACCT GAAGGATACC 98821 GAGAAGCTAG GTGTGCAAAG ATGTGGGGAC AGAACTTTTG GACTGAATAG CAAATACAAA 98881 TGCCCTTGGG TGCAAGCTTT GCCTGTTCAA GGACCAAAAA GAAGGCCAGT GTGCCTGCAG 98941 CATACTAAGC ACAGAGGAAA ACACTGTTAT ATGCTGAGAT TGGAATTATA AGTAGAGCCA 99001 GATAATATAG TCTCTTATAG GTCATAATAA GGCAACCAGA TTTTATTCCA AGAGGATTTA 99061 AAAATCACTG GAGGTTTTGC ACTAGGGTGA GAGGTGTGAT TTGTATTTTT AAAAGATAAT 99121 TCTGGAGAAT TAACTATAAT GAGGTAGGAG TAAACTAAGT TAGGGGCTAT TTCAGTGGCT 99181 CAGACAAGAG ATAATGGTAG CTTAGACTAG GATAGTAGTC GTAGAAATAA ATAAAAGTGG 99241 CACTCTACTT TGGGGGTAGA GTCTATAATA GGTTTGGTTT ATGGATCATA TATGAGAGTA 99301 AAAAAAAGAA AATAAATTAA TAATGGTTCC TAGGTTTGTA CCTGAGCAAC TGAATAAATG 99361 GGTGCTGTGA ATTGAGATAA AGGAGATTGA GAATCACAGG CTTTGTTTTG CAAATTAATT 99421 TTGAGAGGCT TATTAGACAT CCCAGTGGAG ATTTCAGGTG AGTGGAGCCC ATTGAAAGGT 99481 AAGGGACAGG GTCAGGTGTG GTAGGTCAGG CCTGTGATCC CAGGACTTTG GAAGGCCAAG 99541 GCAGACAGAT CAGTTGAGCT CAGGAGTTTG AGACCAGCCT GGGCAACATG GGAAAACCCT 99601 GTCTCTACAA AATATGCAAA ATATTACCTG GGCATGGTGG CATATGACTG TGGTCCAAGC 99661 CACTTGGGGG GCTGAGATGG GAGGATCACT TGAGTACAGG AGGCGGAGGT TGCAGTGAGC 99721 CAAGATCTCG CCACTGCAAA CCAGCTTAGG TGACAGAGTG AGAACCTGTC TCAATAAATA 99781 AATAAGAAAC GTAAGGGAAA AGGAAATTAA TCTGATCATT GGCAAATGCA TAGTATTTAA 99841 AGCCAGGGGA GTAGATGAGA TACTCAAAGT AGGTGAAGAT AAGGAGGCAA TGAAGGCCTA 99901 GGACTCTGGT GTACATTTAG ATGGTTATAA GAGGAATAGA AACTGGCAAA ATAAGTAACA 99961 CTGAGCACCC AATGAGGTGG AGAGGAAAGC CAGGAGATGA AGCATCATAG AAGGCAAGAG 100021 AAGAAGGGTG TCAAAGAGGC GAGGCAGTCA TCAACTTCTG GGCAGTCAAA TAATATAAGG 100081 ACAGAAAAGT GACCATTGGA TTTGGAAATA TGATGAGCAC TTTGAGTGGA GTGTTGAGAC 100141 AGAAGACCAA TTAGAGTAGA TTGAGGAGAT AACGAGAAAT GAGAAAATGT AACCTGCAAG 100201 CACAGACAAT TCTTGAGAGA CTTTTCTGTG AAAGGAAACA GACACAGAGT CTTAGCATGT 100261 CTTGTCTTTC TATGGGAAAT GTAAATAGTT TGAGATCAGG GATAGTATTT TATTCTGCTT 100321 TTTGTACCTC TACATTACCT AGCATAGAGC TAGCTAATGT GCACTTAAGT ATGTTCTCAA 100381 TTCTTATCGC CTGAATGACT GGATGGGTGA AAGAATGGAT GGATGGATGG ATGGATGGAT 100441 GGAAGGATGG ATGGATGGAT GGAAGACTTC TGATTTGCCA AGAAGAGGAT ACTGGTAGCA 100501 GAAATAAAAA CAGCACTGGA GAAAGAAGAG TTTAGATTTT TATTCTTTGG TGTCAGTTAG 100561 ACAGGAAAGT AAGACATTAG AAGAGTCCTT AGATAATTTA TGTAATTGTT CACTTAGGAT EPI-109 636

100621 TTTTAAATGT GATCACTGAT ATTGGACATG TTCCTAGTGA AGCATTTTTG GTGTTTCACT 100681 GGTTGAAGTT AATAACTGTA AAATTATTTC CCGTTCAGGA CAGAAAAACA GAAAACTTGA 100741 AGCTCCTATT AGAAAGTTCA AGATTCTCTG GGGTTCTTAG GATTTACTGT TCCCAAAACT 100801 CTGTCAAGAA CAAGAAAATG ACCTGTATAC TTAACTGGTC TAGGCAACAG TGGAAAGACA 100861 ATTCTCAGAG AAGATTTGTT TTAAGAAGAC ACTTTCCATA GGAATCAAAC AATAGCTTTC 100921 AGTGACTAAC ATGGTAAGAC ACAGGGTGTT AGCTCTTTCC TTCCAACCTC ATGGCTGTTG 100981 TACCTTACCT TTCGACCCCG TGTTCCTGAA ATTGTTAAAT TCATAAACTT ACCAAGGACT 101041 AACCAGCCTC TGGGGAATTG CTGTATACTT AGCAAACTTA CAATGGACAT ATTTATAAGC 101101 CATAATGATA ACTGACTAAT AGGAAATACC CTCAACTGAA AATGAGAGAT CATCATTTGC 101161 AAATGAGTTC CCTTGCCCAG GCAACTACTG GGGAAAATGT CATGCAAGCA AAATTAATCT 101221 TTGAAATCCT CCTTTTCCAT TTTTTGTGTC TTCCTTTTCC ATAGGCACCA GAAATATCAT 101281 GGTGCCTGGA TCTCATCTCT ACAGAAAAAA AAAGTGATTT GATAAACTGA TTTATATTGT 101341 GTCCAAATGT GATTGTATTT TCAAAGATAA CCTAAGGGGA GAATGCTGTC TGGCCCAACA 101401 GCAGGCTCTC GACTTCATTT CAGACACTGT GGCCAATGGC TGGGAAACAG GTATGAACAG 101461 TAGGTTTCTG AGTCCCCTGG AATTATTCCA TTTATGTAGC CACCTCCATG ACAGGAAGCC 101521 TCCCTACTCT TACTTCCCAG TTTGTTCATT CATGGCACCA GGTTGCAGAT TAAAATTTGC 101581 TCAGTGACCT TTTATCTAAT AATGTGTTAC CTTCTTCTCT TAAAAAGTAC AAGGGACAAA 101641 TGCTCATGGT ATACTTTTAG GAGATTGTGG CTCTCTATTA ACAGTATTTA TTCAACAAAC 101701 ATTTATTGAG CATTTATATG TGCATCATGC TAGGGACTGG AACCTAGTAA GTGTAGCACA 101761 TATTATTTCA TTTAATCCTC ACAACAAACC CATGAGGTTG GTTTTATGAT CCCAATTTTT 101821 CAGAAGAAGA AACTGATATT CAGAACCAGT TAACTAACTG GTTCAAGGTC ATGCAATTTC 101881 TAAGATACAG AACCAAGAGT CAAAGACATG ATTTTAAACC AAAGCTTTTT CTGCTACTCC 101941 ACATTGCTTC CCTAGGTGAG ATCTGAGGCA TTCCGCGAAA AGAGAAGGGT CATAAAGCCA 102001 AGGGAAGACA AGCTTAGGAA AAAAAAGGGA AATGTCCTAA ATAAACAGCT TTCCTATTTA 102061 CCAGAAACCA CTAGTTTAAA AATATAATGG GAAAAATCCT ATTCACTTTA ACAATGTTAA 102121 AAAAAAAAAA GATAGAAGAA ACATAGGGAT AAACTTAACA CATTTGTAGG ATATGTAAAG 102181 AAACTAAAAG ATGTTAATAA TGGCCTAAAG AAAAAAAAAC TTACATGTAT GGGGAGATAG 102241 ACCATCTTAC TGGATTCTAA TATTTAATAG TCTAGGTGTT CCATTTCTCA CCAAATTAAT 102301 GTATACATTT AATACAATGT CAAACGAAAT ATCTTAGGAA TTGCTTACAA ATTGTCAGAT 102361 AATTACAAAG TTTACCTGGG AAATATAAGC ATATATGAAG AGTGAATGGG ACCCCACCAC 102421 TCCCCCCAAA ACAAAAAAGG TCTGAAAAGG ACAGAAATCA AGGAGAGTCT TGCCTGCCAG 102481 ATACAAAATT CTATTATAAA GGTGTATTGA TGAAAACAAT TTAATACTAG TGTAGCAATA 102541 GGCAGCAAAG CAATGAAACA GCATAAAAAG ACCAGAACTA TACCTAATTA TGATGAAGAT 102601 TTAAGGTATG ATAAACATGA CATAATTCAA ATCAGCAGAA ATTGGCATAG ATAGGGTTAA 102661 GACAAATAGC TAATCATTAG AGGGGAGGAA GGAAAGGAGG GAGGATAAAA TTAGGTTCCT 102721 GCCTTCATCT TACATTAAAA TAAATTCCAG ATGTATTACA TTTAAATTTT TTTAAAAAAA 102781 GAAACCACAA AATACTTGAA GAAAATATAA GTTGTTATAT AGTCTTTTGA TGGGAATTTT 102841 TTTTTTTTTC AGAGACAGGG TCTTGCTCTG TCACCTAGCC TAGAGTGCAA TGGCATGATC 102901 ATGGCTCACT GCAGCCTTGA ACTCCTGGGC TCAAGTGATC CTCCCAGCTC AGCCCCCCAG 102961 GTAGCAGGAA CTACAGGCAT GCGACACCCC ATCCAACTTA TTTTTTATTT TTTGTAGAGA 103021 CAGGGGTCTT GCTTTGTTTC CCAGGCTTAT CTCGAACTTC TGCCTTCAAG CACCTCAGCC 103081 TCCCAAAGAG CTGGGCTGAT GGGACATTTT TTAACATAGT GCCACATTAC CATAAATGAA 103141 AAGCTTGTAA AATACTAATT TTTAAAACTA ATATATATCA GAAATTTTTA TAAACAAAGT 103201 TAAAAAGCAA ACACAAAAAA TTTGTAGCAC TTATGACAAA TATATGTATA TATATGAATA 103261 CAAAAAGAGC CTTTACAAAA CAGTAAGAAA ACAATGAATA CTCCCAATGG AGTATTCAAA 103321 ACTAAACTGC TAAAAGCAAT TCAAAACAAA AAACATAAAC TATGCATATA TGTATGTGAA 103381 AAAGTTTAAC CTTATCAAAG AAGTAAACTC TCAAAGAAAT AAACATCAAA TAAGGAAATA 103441 GCCTTTTCCC ACAAATAACC AAAATCTGTA AGAATACTGA GCTGCGAATG TTTCAGAAAA 103501 AAAAAAAAAT CATACACCTA GTTCGGCATG TAATTAATAT AGATCAGAAC ACTTTAAAAA 103561 TATTTATAGG CCAGGCACGG TGGCTCATGC CTATAATCCC AGCACTTTGG GAGGCCAAGG 103621 CGGGTGGATC ACCTGAAGTC AGGAGTTTGA GACCATCCTG ACCAACATGG TGAAACCCTG 103681 TCTCTACTAA AAATACAAAA ACTAGCCAGG CATGTTGGCG TATGCTGGTA ATCCTGGCTA 103741 CTCGGGAGGC TGAGGCAGGA GAATTGCTTG AACCCAGGAG GTGGAGGTTG CAGTGAGCTG 103801 ACATTGTGCC ACTGTACTCC AGCCTGGGCA ACAAGAGCAA AACTCTGTCT CAAAAAATAA 103861 TAATAAATAA AAATAAAATA TTTATATACT CTGACCCATC AATTTGTCCA GCATAATTAG 103921 GCATGTGTAC AAGGGTTTAC ACACAAGAAT GCCTATTGCA ATATTGCTTT TAATGCTAAA 103981 AAAAATTGGG GAAAATGCTT TAAAAATATA GATTAAGACT GTACATTGTG GTACAGTCAT 104041 ATAATCAATA GTATACAGCT ATTATTTATT TTCAGCCACT GTCCAAAATA TAGCCTGGCC 104101 TAACAACATT CTGTTAGGAT ACGCAAGCAC CGTGAGGAGA TCAGCTATAA AGTATCAGTG 104161 TTTCACACCA CTGCTCCTTT GCTAATAACC TTCAATGGCT TTTAAAGAAG TAAAAAACAA 104221 AGGCAAAATT CCTTAGTCAG CCCTTAAGAC TCTCTGTTAC TTAGCTCAAA CTACCCTTTT 104281 CAACAACACT GCCCTAACCA GGATGAGTTT TTTGCCCCCC TGGAGTACAT TCAGCCTTTC 104341 CTTATCAAAC CTTCCTTTAA ATAAGTATCT TCTCCAGGAC CACTTCACTT TCTTCCCCAA 104401 TTTAGCATTT TCTATATCTC CAGGCCTACC TCTATAAAGC CTGTCCTAAC CACTCAAACC 104461 CTAGCTTTTT CTCTGAACTG CTAGAAATAT TTTTCTCTCA TTGGCCATTT AGGTAAAAAG 104521 GTTTTTACTG TTTATTACCT ACTCAATAAA AATTTTCTTT TTTTGAGACA AGGTCTTACT 104581 CTGTCGCCTA GAATGGGGGG AAGTGGTGTG ATCACAACTC ACTGCAGCTT CTACCTCCCA 104641 GCTCAACAGT CCTCCCACCT CAGCCTAGTG AGTAGCTGTG ACTACAGGCA TGTGCCACCA 104701 TACCCCACTA CTTTTCATTT TTTATTTTTT GTGAGATGGA ATCTCACTAT GTTACCCAGG 104761 CTGGTCTGCT GATCTCAATT GATCCTCCCA CTGTGGCCTC CCAAAATGCT GGGATTACAG 104821 GCATGAGCCA CAATATCTGG CCCCAGTAAG CTTTTAAGGC CATTAACATG AGGAACAGTG 104881 TTCTTTACAC TATTTTATCA GCTAGGGCTT TGCATGGAGT AGGAGTTTAG TAAATGCGGT 104941 TGATGGGTTA ATCAATGTGT GAAAATATTC AGAGCCACCA AAAACAGATA TTATGTCTAT 105001 TCTCATCAAC AATCAAAATT GAGTAAACAG CCATTTTCTA ATACAGGAAA CCACAAAACA 105061 TTGAATGGTG ACATTAAAAA ATTCCCCCAG CAGGAGCCAA CCAATTTTTT CATCCTGATC EPI-109 637

105121 CAAGTTAGCA AACTGCAAAA GA AGGAAGC ACTAATGAGT GGAAATTTGA GTAGAAGCAT 105181 TTCTTATGAA GGCTGTCTTG ACTGGATCAC ATTTTTATTG CTGTTGGAGG TGCCAAATGT 105241 GTGTGTTTAT GCTAATCCTC CACCTCAGGC AACACACAGT CAAGGATCCT ACCAAGTGTT 105301 ACCGTCAAGT GTCTGTTGGC AGCTCAAGGC CCCAGCGTTG TTCCCTTGCA CTAGGGAAAA 105361 GACATATTCC AGGTACAAGT ACTCCCACTT TGATGCTACA GAGGAGTTGC TGAACTTTGT 105421 GTCATTAATC TCTCTTCGTT AGATCCCAAC CCTGTTTAAA TCCCACTATC TGCCTACTCT 105481 GGGTCTTCAC CAATTTACTA GATCATAGTT GGAGAAAATC TACAAAGCCT TGCTCCCTTT 105541 AGATTTAAAC AGGTCTCCGT TTAAATTTAG AATTGCTAAC TTCAAGCGGG CCCTTATGCG 105601 ACAGTATGCC TGTCAGTCAT ACTACATTTC CTCAATTCCA TTCATGTGAC TGCTCCATAC 105661 CCTTCCCTCT CTCTTCATAC TACTATTATC TCTTCCCCCC TCCCTCATTT TTAACTGATG 105721 ATCTTGTTTC CTATTTCTCT GAGAAAATAG AAGCCATCAA AAGAGAGTTT CCACAAACTC 105781 CTACTGCCTT ATCTAGCCCT GTACCATATA CTTTGCATTT CCTCTCATTA CCATGGATGT 105841 ACTGCCTATC TGTGCTTCTA TCTAAGGCTA ACCCTTCCAC TTCAGTTTTG AATATTATCA 105901 GCTCTTACCA ACTCAAGGCC ATTGCTCTAG CAATTCTCTC ATTCTCTCTC ATTTTCTTCC 105961 ATCAAGTTTT CCTTTTCTTC AATTAACAGA GTAGCTCCTA AAGGGAAAAA AAAGTCTTCT 106021 TTTTCAATGC TCATCATCAC TGGCCATCAG AGAAATGCAA ATCAAAACCA CAATGAGATA 106081 TCATCTCACA CCAGTTAGAA TGGCAATCAT TAAAAAGTCA GGAAACAACA GGTGCTGGAG 106141 AGGATGTGGA GAAATAGGAA CACTTTTACA CTGTTGGTGG GACTGTAAAC TAGTTCAACC 106201 ATTGTGGAAG ACAGTGTGG.C GATTCCTCAG GGATCTAGAA TTAGAAATAC CATTTGACCC 106261 AGCCATCCCA TTACTGGGTA TATACCCAAA GGATTATAAA CAATGCTGCT ATAAAGACAC 106321 ATGCACACGT ATGTTTATTG TGGCACTACT CACAATAGCA AAGACTTGGA ACCAACCCAA 106381 ACGTCCAACA ATGATAGACT GGATTAAGAA AATGTGGCAC ATATACACCA TGGAATACTA 106441 TGCAGCCATA AAAAATGATG AGTTCATGTC CTTTGTAGGG ACATGGAGGA AGCTGGAAAC 106501 CATCACTCTC AGCAAACTAT CACAAGGACA AAAAACCAAA CACTGCATGT TCTCACTCAT 106561 AGGTGGGAAT TGAACAATGA GAACACTTGG ACACAGGAAG GGGAACATCA CCCACTGGGG 106621 CCTGTTGTGG GATGAGGGGA GTGGGGAGGG ATAGCATTAG GAGATATACC TAATGTTAAA 106681 TGATGAGTTA ATGGGTGCAG CACACCAACA TAGCACATGT ATACATATGT AACAAACCTG 106741 CACGTTGTGC ACATGTACCC TAAAACTTAA AGTATAATAA AAAAATATAT ATATATATAT 106801 AAAACAACTA AAAATAAATC TTCTTTTTCT GCAGGATCAG TCCATCACCA CACACACAGG 106861 CTGTGTTTTA TGTTGTTCCC CAGCTTAAGA GATCGTTCTC CAGATCCCAC TGCTCCTTCC 106921 AGTTGTCACC TCAGTTCTCC ACTTCTTTTT GCTGATAAAC TACTCTAACT AGTTACATAT 106981 GATTTCTGTC CCCAGGTCCC CTCCCTCAGT TGTTTTGAAC ATAATCATTT ATATCATTTA 107041 TCATTTTCAC TCTAATTGCA CAACCAAAAA CTCCCTTTTT TTTTAGATGG AGTCTCACTC 107101 TGTCACCTAG GCTGGAGTGC AGTGGCATGA TCTCGGCTCA CTCCAACCTC CGCCTCACGG 107161 GTTCAAGTGA TCCCCCTGCC TTAGCCTCCT GAATAGCTGG GATTATACAC ATGCACCACC 107221 ACACCTGGCT AATTGCTTTG TTTTTGTTTG TGTGTGTGTG TGTTTTTTTT TTTTTTTGGA 107281 CAGAGTCTCA CTCTGTTGCC CAGGCTAGAC TGCAGTGGCA TGATCTCAGC TCACTGCAAC 107341 CTCCACCTCC TGGGTTCAAG CGATTCTCCT GCCTCAGCCT CCCGAGTAGC TGGGACTACA 107401 GGCATGCACC ACCATGCCAG GCTAATTTTT TTGTATTTTC AGTAGAGACC AGGTTTCACC 107461 ATGTTGGTCA GGCTGGTCTT GAACTCCTGA CCTCAAATGA TCTGCGCACC TGGACCTCCC 107521 AAAGTGCTGG GATTACAGAC TTGAGCTACT GCGCCGGGCT ATTTTGTGTT TTTAGTAAAG 107581 ACGGGGTTTC ACCATGTTGT CCAGGCTGGT CTCAAACTCC TGACCTCAAG TGATCCGCTC 107641 GCCTCAGGCC CTCAAAGTGC TGGGATTACA GGAGTGAGCC ACCATGCCTG GCCATAAAAC 107701 TGCCCTTTGT TAATATGACT GTTGGCCTGC ACATTGTCAA ATCCAGTGGC ATTCATCTTA 107761 CTCGGCCAAC CTACGGCATT TGACACTGTC TGTCTTTCCT TCTGTTCCTC TATCTGTTTC 107821 CAGTATACTG GCCTGGCTTT CTTTTTACCT CTTTTATATG CTCTTCCAGT CTCAGGCTCC

107881 TTTGGGGATT TGAAGGTATG TTGCATTTTG CTATTCAATG AATAATGACA AGTAATGATC 107941 ACTTAAGACA TTAAGTGGTC AGTTCCTTTA CTAGGATAAA AATAATTTTC TTCCCAACAT 108001 GGGGCATATT CCATTTCCAG TCTGACTGTT CTGTGTAATC TTTGTATTCC TTGGCAGCCC 108061 CTTTTATATC AGTTCATCTA CTGTGCAGGA AATTGGACAA ACATTTGCAC TGGTATAACC 108121 AAATACAGTT GAACTTTTGG CTTGACTCTT AGCTGAACTC ACCAAAAATA ATTTCTGTAA 108181 GAGACTGAGA CGTCTACGAG TAGGTTTTTC AGAATTAGTA AACATAAATC AAGGATACAC 108241 AGGTAGATTT GAATTTCAGA TAAACAACAA ATACTTTTTT AGTATGTCTA CTGAAATATT 108301 TGTATCTTAT CTGGCAATTC TACCTGGTAC AGAACTAATC CATTCTCTTG AAAGATCTTG 108361 ACTCTGTAAT AAGTTCTTTG GTGATGGAAG GGAGGTATTT CTGTAATTAG AGTCACTGTC 108421 TTCCTCCCAG TTTTTTATCC TGGCCCAGAT CTGCAATGAA CACACGACAG AATCCAGGGG 108481 GGATGAAGAT GGGTGCTTTG CAGGAAAAAA AAATTAAAAA CATCTGAAAA AGCTTTTGTA 108541 CTAAAAGAAT GTGATCTAAA AAAGAAAGCA GGAGAACTTT CTGTCTGCAC TTTACATCAG 108601 AACAACCTTG GCGTCTAGAA GCTGTGCCCT GTGGGAAGTG GTGGTGCTTG GTAAGAGATG 108661 CCAGGACCAG TGGTACCCAC TGGGAGCACT GCCAATACCC AGCAAGGAGC ATGGGTGCAC 108721 AGTAAGGCAT TGCACTGTGA TTCAGCATAA AATAACAATA AGGGAACGTC ACGGAGAAAA 108781 GGCCAGACTT CCTTTGTTTA GAATGTGGGA AATGTCTTCT GAAAAATGGT AGTAAAAAAG 108841 CATGCTTGGA TGGTCCACTC CAGGCAAAAC TGACTAATCG GGGGTCAGGG ATACAACCCC 108901 TGCATCATAT GTTTGTTTCT GTTGGGCTGA CATGAGGTTC ACTGTGACCA CTGTGGTTTA

108961 ACCCCATAGT CTCCTGGAAA TACAGCCAGG TCAAGAGAGC TCCACATAAA ACATAATCAA 109021 AAAAATAAAC TCAAGTTTCC ACTGATCAGC TTTTCACAAC TCTTATCCTT TCACTAACTT 109081 TGGAGCAAGA TTTGAGAATT GGATGGCTAT TTGAGGGCTA TTTCTGCGCT TTAGTTCAAT 109141 GTTTTGTTCT TTCTTTATTA GAGAACTATG GTTTTTTATT ATATTTACAC TTTAAGTTCT 109201 AGGGTACATG TGCACAACGT GCAGATTTGT TACACAGGTA TAAATGTGCC ATGTTGGTTT 109261 GCTGCACCCA TCAACTCGTC ATTTACATTA GGTATTTCTC CTAATGCTAT CCCTCCCCCA 109321 GTCCCCCACC CCCCGACAGG CCCTGGTGTG TGATGTTCCC CTTCCTGTGT CCAAGTGTTC 109381 TGTTTATGTG ATAGATTACG TTTATTGATT TGTGTATGTT GAACCAGCCT TGCATCACAG 109441 TCACTTGCTT ACAAGAAACA AACACTTCAC AGATGGATCA TTATGTGTGA TAAGTGAAAT 109501 CCAAGGATTT ATGCTCAGAG GTGGGCTTAA CAGGTAGGAA GAGCAGTATT TTCCTTCAAC 109561 CATGAGTGTA TGCAGGTTTT TCTTTTCTTT TTTGAGATGG AGTCTCACTC TTTTACCCAG EPI-109 638

109621 GCTGGCGCGC AGTGGTGCGA TCTTGGCTCA CTGTAACCTC TGCCACCTGG GTTCAAGCAA 109681 TTCTCCTGCC TCAGCCTCCC AAGTGGCTGG GATTACAGGC ACCTGCCACT GTCTCCGGCT 109741 AATTTTTGTC TTTTTAGTAG AGATGGGGTT TCACCATCTT GGCCAGCCTT GTCTTGAACT 109801 CCTGACCTCA TGAATCATCC TTCTCAGCCT CCCAAAGTGC TGGGATTACA GGCATGAGCC 109861 ACTGCGCCCA GCCCACAGGT TTTTCAAAGA CTAAACTTAA AAAAAAAAAA AAAATTTCCC 109921 AATGAAATAT AAAACTAAAG TGCTAAACTG TGATAGACTG TTTTACAAGA ATGCCAGTTT 109981 TCACAAGTGT CTATAGAACA TGTAATTTAG ATAGGTAAGA TGAAATTTTG ATAATATTTG 110041 ATGGCAAATT TAAACAGGTA TACAACAAAA ATAAAATTCT AAGCCCCTCA ACCAACTGAA 110101 TGGACTCCTT CTCTCAGCCA AAGGAATACC AAAGTAAACC TGAAAAACTA GTTTTGGCCA 110161 GGATTGGGGG TAGGTGGGGG AAGCCCAACA TGACTCATTA TTCTCTCCTC CCTTTGGAAT 110221 TCAGGCACAA CTGAATGTCA GCATTGACAC TAAAACACAG ATCTTAAGAC TGACAAGCCA 110281 GACTCTTTGT AGCAGAGAGC CAGGCCCTGG AAGAAATCAA GTTATTTTAT CCCAAAAAAT 110341 ATTTCTTTGA TATATTTTCA AATGGCCCTG CAAAGCTGTC TCTTGTGGGG AAAATTGACA 110401 TGCTGTACAG AATTTCCTTC TCTTTCCAAG TTTTTACTGA TCCAGGAGAG ATTTAACTAA 110461 GAGGCTAGCA TGTTTTTTTT TTTTTTTTTT TGAGGCGGAG TCTTGCTCTG TTGCCCAGGC 110521 TGGAGTGCAG TGGCGTGATC TCAGCTCACT GCAACCTTCG CCTCCCGGGT TCAAGCGATT 110581 CTCCTGCCTC AGCTTCCCGA GTAGCTGGGA TTACAGATCC ATGCCACTAT GCCCAGCTAA 110641 TTTTTGTATT TTTTGTAGAG ACAGGGTTTC ACCATGTTGG CCAGGCTAGT ATTGAACTCC 110701 TGACCTCGTG ATCCGCCCAC CTCGGCCTCC CAAAGTGCTG GCATTACAGG CGTGAGCCAC 110761 CGTGCCCAGC ACAAGACATT TACCGTCTAT TCTCTCTGAA GCTACTATCT AGAGGCTTCA 110821 TCAACATAAT AAGACCCTTG GTCTCCACAA CTCCTTATCT TATCCTATTA GTTTCTACTG 110881 ATTCCAGGTC TTTAGATAAT AACAACTCTT TCAACCAATT GCCAATCAGA AAGTCTTTGA 110941 ATCCACCTAT GACTTAAAAG CCCCACTCCT TCAAGTTATC CCGCCTTTCT GGACTGAACC 111001 AATGTACACC TTATATGTGT TGATGGATAT CTGCCTGTAA CTTCCATTCC CCTAAAATGT 111061 ATAACATCAA GCTGTAACCC AACCACCTTG GGCACATGTT TTCAGGAACT CATGAGACTG 111121 TGTTGCAGAC CTTGGTCACT CATATTTGGC TCACAGTAAA CTTCTTTAAA TATTGTATAG 111181 AGTTTGGCTT TTTTCATTGA CACAGGAAAA ATAAAGAATT GGAAGGTCTT TCATCAGTCA 111241 CTGAGCCAGC TTCATATCTG ACTGAGGTCA TACAGTTCAG TGATTTGTAG CTTTGCTACT 111301 TAGATTGCTA TCCATTATCT AGAAGCATCA GGATCACGTG GGACCTATTG GAAATGCAGA 111361 CTTTCCTCCT AGAACCCAGG ACCTTGGAAT ATTCTTGGCA CATAGTAGGT GCTCAATACA 111421 TATTGAACTC CTAGGTGCAA TTCATTAATT CATGAATTAA TGAATTAACA CGCTCTCAAA 111481 GTTTAGTGCT TTTTCACAGA CTAGTCTTTC TGCCTCTTAA GCACTCAGCT CACCACGCTT 111541 CCAGTCTCAC TCCCCTATTA GTCTGATTAA AATCTGCTTA CATGTGAGTC TGAGATCAAG 111601 TGTTATCTCT TCTGAGAAGT CTTCCCTCAC TGGCCCAAAG GAATTTCTCC TCTATTTTAG 111661 CACTGTCCCA GTTGACTTGT CATTATTCTA GTCTTTTTCA TATTAGTTGT TTTTCATATA 111721 TATGTTATTA AGGAAACTAG TCATTTCCCC TAATAGAACA AAATTGCTGG CCTTTGGGGT 111781 TGGCAATGGA GGGGAGGCTC TTCTTGAAAA GGGGGAAGAG TGTTCTCCTA ATATTTTTCT 111841 TACGAGATTT ATGTTGCTCA TCTTTAGCCT TTAGTCCCCC ATTGCCTGCC TACAGTTGGC 111901 AGAGACCATC TGTTCTCTCA CTGTCAGGAA CTGTCTCAAT TCTTGAAGTT CAGAGTCAAA 111961 AAAGAAGCAA GTTTTCCTAG CTCTTTGATC AACTTTCAAA GTTTTACTTC CATTTGAAAA 112021 TTTACTAAGT CACCAGGAGA TGGTTTATAC TGAGAAATAT CCACTCATAC TCTTCCTCTT 112081 CAACTTTCTT CCATATACAC CCTATTACAG GGATATAGTC TTACTCTATA GCTCAAAAGG 112141 ATGACCCTAT CAGAAACCTG CACAGTATGT AAAACATTCT CACCAGAGGT TCACTTGTGT 112201 ATTTCCACCC TAGAATGGAA GCTCTACAAA AGCACAGAAT GTATCATTTT AACTTTAGAT 112261 TCTATTTTCA CACCCAGTGC TTGACACATG ATTTGAAGTT AATATTTATT TATCAAGTGA 112321 TTGTTTTAAA ATCATGACTC ACTCAACAAA GTTATAAGAA TAAGAATAGT GTTACAGAAT 112381 TGGTATACAC AAGCTGACCA TAATCAACAC ACCTATTATC ATTTTTTTGC GACAGGTTCT 112441 CGCTGTCTCA CCCTGGCTGG AGTGGAGTGG CATGACCACG GTTCACTGCA GGTTTGAACT 112501 TCCAGGCTCA AGCAATCCTC CCACCTCAGC CTCCCACATA GCTGAGCCCA CAGGTGTGTG 112561 CCACCATGTC CAGCTAACTT TTTAATTCTT TGTAGAGACA GGGTCACCCT ATGTTGCCCA 112621 AGCTGGTCTT GAACTCCTTG GCTAGAGAGA TCCTCCCTCC AAGGTCCCCC AAAATGCTGG 112681 GATCTCAGGC AAGAGCCACC ATGCCTGGCC ATAATCAATA CACTTTTAAG AATGCTAGAA 112741 TGTTATATCA GATGCATACT TCAGCACTAT CTCAAGCAAA CTGGGGTGTG GGTTATTCTA 112801 CATATAAAGT TCAGCAGTGT TGTTCCACAG TCCCAAACTC CAACTGAGGT CAAATGTAGG 112861 GTGCAGCAAG GTCACTGGGG CTGTCATCAA GGGCCTCTCC TTGCACTCTT GCCAACCCTG 112921 TTTCTTGATT GTCTCTACCA CCATGAGTCA CCAGCAATCT CCCACAGTCA CTTGTTTAAA 112981 AGTTCACAAG TATTGTGTGA ATTGCAGGCA ACCCCTTGAC TCCCTGATTG CCTGGTCTTC 113041 TTCCTTGGGC TCTACCATTT TTTTTCCCCA GCACTCTTTC TGCTGCTCTA AATTTTAATT 113101 CATGCAATTC CATATGTGTT TCTCTATCAT TCTTCATCTC TTTCCTCTCC CTTCCATCCA 113161 ATTTTGTTTG TCTGTTTCCT TGCTTGCTTG CTTTAATACA TTTCTCTTTT TCTGAGAAGG 113221 CTTGAGTCCA AAACTCTCAG TTACCTGTTG TTCTGTTTCC CGTTAGTTAA TCTCCGAACC 113281 TTCATAAATT AAATCTGACA AAGTCCCCTG ACTAACAAAG GAAATGCACA AGTCACAGTA 113341 AAAGGGGCAC ACACAGAACA CAAATAGACC CAGGGTCTTT TCTGTTCATC ACTCAGCTTT 113401 TTATAGGAGA TCCAGGAGAA ATGAAGTGGA AAGGGAAGTG TGTTGAGTTA CTATACAACA 113461 CAAGAGTAAA CTTTCTTATA AGTGGTAATT TTTTTTTACA GGAATAATTG AAAATGGAAA 113521 TTACCTTCTC TACTCATAGT AAGTACTCAG TGCGTTCTTG ATGGGATGAG AATGTGTTTG 113581 AGCTTTAGTG TAAGGCAGAA TTCTGTTTAG TCTGCCAGTA TTGGAGAAAA ATAAAACACA 113641 AAGGGACTGA CATGTAGGAA GTGGCACCTG GGAGGGTCTC AATTCTTCCT ATTACAAAAA 113701 TGCCCCAGAG AAATAAAAAG CTTGTGTACA TGTTGAGATG GGAGAGTTCT CTGGCCCCCC 113761 TCGCAGGATG TGTGACAGTG GGGTGGCTCT CTGCTGCGCC ACCATGAGCT CAAACCCCTC 113821 ATAGGAGGGG GAGCACACAG GCAGGAAGGT GCAGGAGCTG GGCGAGCTCT TTGGGCTCTG 113881 GCCCCGTGGT ACTGTCTAGA GGTGGGTGCC TGCAACTCCT GAAAGCCCAA GTGGGCATGT 113941 GTTACAGTGC ACTCTTTCAG CTTTGCTGTC TGCAGCTTAA GCGTTAACCA GCTCAGTTTC 114001 TTCTTGGTAC CCAGGTCCTT GTCTGGCATC CAGGAAGAAT CAGGTTACAC ATGGACTTGA 114061 AGGATGAATG TGGGAGTTTT ATGGAGTGGT GGAGGTGGCT CTCAGTGGGA TGGATGGGGA EPI-109 639

114121 GCTGGAAGGG GGATGGAGTG GGAAGATGAT ATTCTCCTGG AGTTTC-u<~T TCCAGCAGCC - 114181 GATCTCCTCT CCAGTCGTCC CCAGCCTCTC GACGTTCAGA TGCTCCTCTT CTCTCCTTCT

114241 CTGCCATGCT GTTCTGCCGT TCATCTGCCT GTCTCTCTCT GGAGCCTGGA ATTTGGGGTT 114301 TATATGGTAC ACAATAAGGG GCATGGCAGG CCAAAAGGGA ACTTTTTAGG TGCAAAAAAC

114361 AGGAATGCCT CTTCTCACTT AGGGCTATAG ATTTTCAGGC TTGAAGGTGG GGCCTTTACC 114421 AGCGAACCTG TATTTCCCTG TCTCCTGTGC ATATCAATGT AATCAAATAC TGGGCTGATC 114481 CAGGATGTTT CTTTAGACCA ATTATGGGTA AAATAATTTA CATTCAGGTT TTTATATTTG 114541 CTTTTGTCAT TTCTTTTTAA GCAATCATGT AAAATATCTA TACGACAGTA ATAGATGATA 114601 GCGAACCTAA TTAAAATTAC CAGAAACTTA AGAATCTCTA ATGATTTCAA CTGTAACTAA 114661 GGTTATTTCT CTTTATGTTG AACAATGTTG GGAGATAAGA CACAAGAGTT TCTGAAGTAT 114721 TTCAGAAACA CAAAGAGGGA GGTTATATAA ATAATATTTT TTTCCTACTT TGGGAAAATG 114781 AAAGCTAGTC ACAAAGTTAA ACGAGTGGTT ATTTTAATAT TTAAAATACA GGCTTGGATG 114841 TATTTCCTGT TAAAGAAAAT AAAATGCAGA ATATTCAAAA CGTCTGACCA CCCTTCTAAG 114901 AAAATGCATC TCTGAGGTAT TTTTCCTTAG AAGTTATTGT AAAAATCCTG GAGAAGCTTG 114961 AACACAGCAA AGCAAACAGG ATGCAGAGTT TAATCTGTGG AAAGCTTAGG GAAGAAAAGC 115021 AAATCATTAA AAATAGGTCT TCCTCTGAAG ATTTTTAAAA CGCAAAGAGG GTGGAATAGC 115081 AATGATAATA AAAAAGCTGG CATAGAGAGT GGCACAATTT GCTGTGCCAC TGAGCTGACT 115141 GGATGTGTTC TGAATTTCTA GGCATTAGTG TACCTTTCCA CACGCATTCT CCCTTTAAAA 115201 AAAATGCCCA CACACTGAAT ACTTTTTTCA TGCAATTTAA AATAAGCGCA CCATCTAGTT 115261 TACAGAAATT CACTAGAAGT TATTTATCCT AAAATAGCAG AGATCTAGAA GAATTTTGAG 115321 CTCTAGGACA TTTTAGACAC ACAGAAAGAA GAATCTGGAC AAGTCTTGAC CAGACATGAC 115381 AGAATAGAAA TTTCTTTTCC TATTTATCTC TTTGAATAAA ATTTTCAGGA TCTTACAGTG 115441 GACAAGTTTG TTATCTACAC ATTGTGAAGC ACATTGATTT CTCCTCTGTA GCCTTAGGAA 115501 GATCTGAGAG GTGACTGAGC TGATTGAATG ATCCGTGACC GCTCTACTGG GACCAGTAGT 115561 AGAACTTTAC TGGTGGAGAC CTGCTGGAGG TTTGAGAGCA GACTTTGAAA ATTACTAGAG 115621 CTACACAGAT ACTGTGTGGC TAACTGGATT ATGTTTAGAG GCTTTCAGAA CTATGCTGCT 115681 GCTGCTGCAG TGTAGCCAGG ACGCACAGAG AACATCTAAG GCTCTTGAAT GGGGCGATAG 115741 GGACAGATTT CAGCAGCCAT CTGACTTCAG TGCTCATTTT GATGCTTTCC CTGCAGGGTG 115801 CAGTGTGCAG TGTGCAGTGT GCAGTGGTGG GAGGCTCACA CAGGAATACT TGCTTCTGTA 115861 GCCCTAATTT CCGGTTCAAA CTCTGCATTC ACCTTGACAG ATTCTTTCCT TGGCCAAAAT 115921 TTAGTTAGGC TTCTGGGCTT TCTCTTATGC CCACCTGCAG ACTTTTTGGT AAAATCCAGT 115981 TTTAGTAAAG AGCTCTGCTA AGTCAGTTTA GCAAGAATCC CCACCTCAAA AGTCACTATC 116041 TCCCTCCCTG GTAGTGTCTG GCTTGTCTTC AGCGAGAATT CTATTAGGTT CTGTTAGATT 116101 AGAATCCTCC TTACCCTTGA TGCTTCCTCT TAGTATTTTT TCATCCACTG ACTCCTTGAC 116161 CCACCTTGCT CCTCGGCTAT AAATTCCCAC TTGCCCATAC TCTGCAGTTA AGACTATTTT 116221 CTCCCCACTA CTGCAAAATC CCATTGCCAT GGTCCCTATA CTATCTCAAT GGTAATGAAT 116281 AAAGTCTGCC TTACCATGCT TTAACAAGTA ACATTGAACC ATTTTTTTCT TTAACAATCT 116341 GCTGCACAAT GAGATTACTA AAACTTTATT CCATTTTGCC ATGCTGGATG TCCTCAATGG 116401 AATGGCTCTT GTGAGCACCA AATCATTGTG AGAAGGAAAA CCCATCTCTT ACAGCCCCCT 116461 GTAACGTGAT GTATGTTACA TGTGATGTAT GTTACATAGT TTTTTTTCAT GTTGATCACT 116521 TTTTGCCCAT TTTCCTATAT CTTATCAGTT GGAAGACTGT GGAAGTTTGT AGTACTAAGC 116581 CACAAGATGA CTAAGAAGAG TTGAAAGGGC AAGTGGGGCT AAAAACAGAT TTTGTTTGAC 116641 TTACCCCACC ATTCCCCCTA TCATGGGGCT GAATCTGCCT GGAGGAAGGA GCATCTTTAT 116701 CTTTGTACTG TGAACCACAC AGTCTAGCAG CAGCACAGCC AAGGCACTTG GGGTTTCATG 116761 AGACTAAGTA CATGCAATTC TATTGTAAAG GCTTAAAATA TATACAACTG ACCCTTGAAC 116821 AACATGAATT TGAATTGCAT GGTCAGTTAT ACGCAGATTT TCTTCCACCT CTGCCACCCC 116881 TGAGACAGTA AGATCAATCA ATCCTCTTCC TCCTACTCCT CAGTCTACTC AAAGATACTT 116941 GAAGTCTACT TGAAGATGAC AAGCACAAAG ACATTTATGA TGATCCACTT CCACTTAGTG 117001 AATAGTAAAT ATGTTTTCTC TTCCTCCTAA TTTTTTAACA CTTTCTTCTC TCTAGCTTAA 117061 TTTATTGTTA AGAATACAAT CTATAATACA TATGACATAC AAAATATGTC TTAGTTGACT 117121 GTTTATGTTA TCTGTAAGGC TTCAGGTCAA GAGTATGCTA TTAGTGGTTA AGTTTTCGAG 117181 GAGTCAAAAG GTGTATGTGG ACTTTCAACT GCAGGGGGGT GGGCACCCCT GCCCCCATGT 117241 TGTTCAAGGG TCAACTTTAC TGCCAAAGGC AAGCCTTTAC ATCCACTTTT TCCATCCCAT 117301 CAGTAAATGG AAAAAGATAG CTACAGTATC CCTGCGTCAA ATCTTTTTTT TTGCAGATCA 117361 CAAATTGGCC ACTCACCTTG CTCTGTGAGG GGTAAAATGC CCCACTTTCT TTAGTAATAT 117421 TTAAGTTAGA TAATATTTAA GTTATAAAGT TGTTCTTTGT AATCGTTAAT TGTAATTTTT 117481 ACATAGTTTC TTTCAAACAG AAATAGCATT TTTGTTAGAT AACCTCCCGT ATAGATGATG 117541 AAACTCCTTT TAAGGGCTAT CTGAATTTTA ATTCCTTGAA AAGGCAGAAA TTGGATAGCT 117601 AGTAGTCATA AATGTACTGT GGCTTCCCCC AACCATCTGG GCTATATAGA AGCTGCATCC 117661 TTGGACTGCA GTAGAGGAGT CTTACAAAGC ACAGAGCAAC TTCTCTCCTG GGTTGCGCTA 117721 GTTATGATGG CAATTTTAAA TGTGTACTTT TACCCAAAGA AAATCCTTAT TATCAACAAT 117781 CACAATGCCA TCATAACCAT GGTATAAAAA ATTCAAAATG TCCCAGCTGA AGTGGAGGCA 117841 AAGACTCAAG TTCATGGAGT CAGAGTTTCC TTGCTATTCC TCTTTTTCAA ATGACCATTT 117901 AGTAAGCACC TGAAGAAAAT ACTATGGACG GCATTGAAAA GTGAAGATAG GTTTAATCTT 117961 CTCGAAAATC TAATTCTCCA GATGAAACGC TGACACTTAT CCACCCCACA GACCCTATAG 118021 CAGATGTGTC ACTGGCCATC ACATTTGACA CAGAGAAGTC ATAACTCAGT CAGCACAGAG 118081 ACATTTCCAT GAGTTTCTGA ACCATGGACA GAACGTCGTC TGTGGGACAT GAAAACTGGA 118141 ACTTAGAGGA CAGGCACATC TGAGAAATGG GCAGTTTAAA GGCAGAACAT AGCACATATG 118201 TGACTGGGTT TTAGAAGCAA ATTTACAAGA CGCACTCTTC TTCATCCTAA ATAATCTGCA 118261 ACCAAAGCTT CCAAAAAAGA CAATTTAGGA ATGCAGAGGT GAGGAGTAGG GAGGGGAATG 118321 GGATGAGAGA GAGTGGAGAT TAATGGTGGG CAGAGCGAGG TTTAGAACTT AGTGGTTTCT 118381 TCAGGTTCTG AACTGAAATT TGTATACTGT AAAGGCACAA ACACCATTTT TAACAAAAGT 118441 GAGCAGGACT TCCTATCTGG TTCAGAAAAT AGGTGAATAA ATAGTACGAA TTATTAAAAA 118501 TAATAATTTC CACTTATACA TAGGAAACTT GATAGGAACC ATGATAAATG CTTAACTCTT 118561 AATCTTCAAG GAACTCTGCT AGGGATATAA TATTATAAAT CTTGTTTTGC AGATGGAGAA EPI-109 640

118621 ATTGAATTTT AACCCAAGTT ATCATAACCC TTAAATGATT AAATGATACT GTTACATGAG 118681 AAAGCTGCGT ATCTGTTTCC TGGATTTGTA GCCATAATTT GTGTCTCAAG TCCCTTTTGC 118741 TGCCAGCTAT CTTGGGTAGG TGTGTTCCCT TTGGGCTGTT TGATACCCCC ACATTTATCT 118801 TTTTTTTTTC TCTTTTTTTG TTGAGAGAGT CTTTCCCTGT TGCCTAGGCT GGAGGGCAAT 118861 GGCGCGATCT CGGCTCACTG CAACCTCCGC CTCCTGGGTT CAAGTGCTTC TCACGATTCT 118921 CTTGTCCCAG CCTCTCTAAT AGCTCGGATT ACTGGCATGC ACCACCACGC CCACCTAATT 118981 TTGTATTTTT AGTAGACAAG GGGTTTCTCC ATGTTGGTCA GGGTGGTCTC AAACTCCTGA 119041 CCTCAGGTGA TCTGCCTGCC TTGGCCTCCC AAAGTGCTGG GATTACAGGT GTGAGCCACC 119101 ATGCCTGGCC CCAAATTTAT CTTTAATGCC CCAAATTATC TAGTTCCCAT GACTGGGCTT 119161 CTGCTTTGAT CCTTTCTGCA CTTGCTGGAC CCTCTCCCTG GGAAATGAGA TTGTGTCCTG 119221 AGCCCCTAGT TAGAGGCTAT GTCTCTGCTG TTCCTGAATG GGCCTCCTGG ATGAGACCTC 119281 ATTAAAAGTC TAATTCTCTT GGAGAATTGA GAGATACCTA TTTGTCTCAA AATCATTGAA 119341 ACCAATTAAT GTATTATGAG CCTCTATCCA GTGATTTGTA CCTCAATTCC CCAATCCAGC 119401 TGTCAAGGCC AATTTGTTCT ACCTTACCTA GTAGGTAAGT CTGGAATTGT AGCTGTGGCA 119461 TTTTCAGTAA TGGTACTCTA GGTTAGCAGT CCCCAACCTT TTTGGCACCA GGGACCAGTT 119521 TTGTGGAAGA CAATTTTTCC ATGAAGGGCT GGGCAGGGGA GTGGTTTCAG GATGAAACTG 119581 TTCCACCTCA GATCATCAGG CATTAGATTC TCACAAGGAG TGCGCAAGCT AGATCCCTCA 119641 CACATGCAGT TCACAATAGG GTGTGCACTC CCATGAGAAT CTAACACCGC TGCTGATCTG 119701 ACAGGAGACA GAGCTCAGGC AGTAATACTC ATTTGCCTAC CGCTCACCTC CTGCCGTGCA 119761 GCTCAGTTCC TAACAGGCCA CGGACCAGTA CTGGTCCACG GCGCAGGCAT CAGGGACCCC 119821 TGTTGCTAGG TATAAGCATC TGGCTGCTGC ATGTCTTCTG TGTAGCTACA TCTGTATGTG 119881 TATCTGATGA GATATAAATT ATTTGATTAT AAATTACTTT CTTCATATTA GAGTTGTGAA 119941 TGAGTATCAC ATATAATTAT ACATAAACTA GGAATATGCT TTTTAATAAT GTATATAAGT 120001 AAGTTTCCTT AACTATGACT TTCATCTTAG CGTAGTAAGA GGGTGCTAAG AAATATTTGT 120061 GATGAAAATA GGCATTGGTA GAGTTGAGAC CACTGGGTGA TGAAAGAGTG TAAAGATTTT 120121 AAAGCCTTCA GATGCTGGTT CAAGGTGAGA AATGTGATTG GGAGCAAATC AATTAACTTC 120181 TTGAAGTCTT ATAGGGCAGT TATGAATACT TAATGTTAAC A ATGTAAAG CTCTTCTGCC 120241 CTGTATACAG TAAATGCTAG TTAGCTATTA TGATCACTAC TAAAATGGGG ATGACATAAA 120301 CCTCATAAGG TTTTAAGTAT TATGCAAGAT ACTATACAAA GTCCAGTAAA TATCACATTC 120361 AATTGAATCC ATGATGTCCG ATTATTTTAG CTACTTCCAA GAGAGAAAAA AATGCTGTCA 120421 GTTTTACTGT TCTTATAGAG AGCAAGGCAG ATCCCAATTC CCAATGTGGT AACGTGAAAA 120481 TTTTTGCATT TGAATCAACA AAACACTTTC TCCTTTCTTT CCTACTATTT AACAACTGGT 120541 AAGTCTATAC TCCCCCAAAT CTGGAATTCT CCTTTCTTAT TCTTTTTCCT CCTACCAAGA 120601 CCGCAGGATC TTTTACTTGG CTATAAGGGG TAAACCTCAA GTAGTACAAG TTCTCTGTAT 120661 TACTTTTATA CTCTGTCACA GATTCCCTTT GTTTCCTCAT CTCCATGTGA ATTTAGTTAA 120721 ATTCTCAGCA TTCTGATCCT TACTATACAA GGTAAATGAA TATAAAAACA AAACGAAACA 120781 AAAACCTCTT CCTATTTACA TAAGGCCCCA ACCTAATATT TAGTGATATA TATTAATGTG 120841 AACAAGGAAC TAACGAAGAC TGGGAAGAAA TTCACAGACT TGAGAGAAGA AATGGCAGGA 120901 TTTCCTGGGA ACAATTTCAT GTAACGTCAA AGGTGGTAAA AGGTCAAATA GAATGAAGAT 120961 GGAGAATACC GGATTTTCTT ACAAAATGAT TTCCCAGGAG ATCTCATCAA ATGCACGAGG 121021 ATACCTTCTC AGTTTCACCT AGTGAGTAAA AGACTGGTAA CATAGCTCAC TTACAATTTG 121081 GATAAACAAA ACTAAACAAA CAACATCAAA ATTTCAGAAA AAATAATAGC AAAACAGAAA 121141 TCAAACACTC AAATTTTTGG TCCTTCTGTT TATTTCATTT TGGATACTCA GTGAATGTTA 121201 ATTAACCAGG AAACTTAAAA GTTATTTCAA TTATGAACCT CTTCAATCCT TCATCAATTA 121261 TTTTGAGTAT TCTGGTCTTA AAAACATCTC TTTCTTCTAC AAACTTCTGA AAGAGATGAA 121321 CACCTCCACC TACACCAAAA TAATGTGCTT TGCTGGCCAA AAGTACACGT CCATTTTTAC 121381 TTAACAGTCT AAGGAAAGTC TGGTGCAAAT TACTATAATA ATCTGGGTTG TAAATGGTTT 121441 CTGAGGTGAG AATGAGATCA TATTTTACAA AAAGTTTTTC ACTACTTAGT ACAAGCTTAC 121501 AAAACTCAGA CCACTCACCA GAAAAAAATC GGCATTTATA TAGTTGTGTT ACTTTTGGTT 121561 TCCTGCATCT TTTCACATCT GGCTCATTTA CATCATTTTC TTCATCTTCC AAAGTGGAGT 121621 TAGCTACTAC ATTAGGTAAG GTTACTTCAT CAATCACCAT ACTGTTATAA TCTTGAAAGT 121681 GAATTTCTTT GGACCCTCCC TTGAATGCAG TTATACCTAG TAAACCTGAT CCACAACCAA 121741 GATCCAAGAC TTTTTTCCCA GCAAATTTCA CTTTGGCCTT TGTGAAATAA GCCAGGAGGT 121801 CAAAGGTACA TTCCCAGATT TTTAAGCCTC CCTCATAAAC ACCTGTAATC AGATCAGAGT 121861 GAGAAGAAAA GCTTTTTGAA ACTATGTTTT CTCCAGGGAA GTTCTCTTTC AACAAGATGG 121921 TTTTCACTAC TGATAACTTA ACATGCTGGA AACCTGGTAA TGTTTCTATG ACTTTATTTT 121981 CTAACATCTT CTTTAAATCT TTAGGCATAG CATGCTCTTT GGCAGCTCTC AAGGAGGGCT 122041 GTTTTCCATG TGGCTCCAAG TTCCTTGAAC TGCTGGCTGC ACTGAGTGGA CTGTCTGTGT 122101 CTTGAGAGGG AGCTGCATTT TCCATTGACT TATGTTCCCA CAAGTGATCC TGAGGCAAGT 122161 CAAATTGTTC TGCAGAACAT TTTCTGTCCC TCTCTTCTCC TTTTTGACTT TCTGAGACTG 122221 ACAGCTCTTT TGAGGAATCC AGGGTCAAAG CTCCATCTCT AATGGGTGTT AATTCATTTT 122281 CCAGATGGTC TTCTATAGTG AAATTAAACT GAAAGGTCAT CCTCTTATTA AATGCACACA 122341 ATCTTTAAAT TCAGATTCTT CAACTTCTGG ATAGAATTTG ATGATACACA CAAATCTGCC 122401 TCAATTATTC AATTAGTTTT GTTGGGCCCA ATTTCTCTTT AGCAGCTTAT ACATGGTAAC 122461 AAATATTTAG AGATATTTCC AAATGACTTT TTAGACGTCT TTGGTCCTCT TTCCAAGCAG 122521 CTCTGGAAAG AAAAAAAAAA AAAAAAGAAA GAAAATGATG ATTAAAGCAA AATGGCACAT 122581 TTCACTAAAG TGTAATATTA AACAGCCACC CCCACCCCTC CCTGTCCCAC CATACAGCTG 122641 CTTTTTCTTA AAAAGTTGTG GGGAAGAGAG AGAGATAAGA GATTTGGACA CTCATACACA 122701 CCTTAAGGGT TCCAAAGTGG GAGAAGAAAA TCAACTATAA AAACAAACAG AAGAACAACA 122761 GCAACCACCA CCACTACCAC CTGGACAAAC ATAAAGTCCA AGATATTCAG ACAGGACAGC 122821 CTAGCTACTT GCTGTCTTTC AGCTGTCTTG ATTTGTGTCC AACCATATTC ACCCCCTAAG 122881 CTTCCAGAAT AACTTCACTT CTGTCTTTTA CAGAAGAGGT GCAGTATTTT ATTTTGGTAA 122941 GTCAGCGTCC CTTTAAAAAC ATGCATAGGT ATGGCCTGGT GTGTGTAAAT TCATCCAAGA 123001 CTTCACTCCA AACATTTAGT CGAGAACAGC AGCCCTAAGT GTATAGAAGT GGGGGTAATT 123061 TGGCAATAAT TAGTAAAGAC TAATTCGGTG GCAGAGCAAA CGCAAACTAG GGCACTGCAG EPI-109 641

123121 TAGTTTGGAG AGACCTGTAG AAATAAGAAG CAACTTTATT GAGAATCTTC TATCTACTGC

123181 GCTAGACACT ATACCATCTG CCTCAATTTT CACAGTTCTG GCAAGTGGGA TCTTTGTTCC

123241 CTTTATACAA GATTTACAAT TTGGGGGAGA GGCGGGTCAC CCAGTCCCGC GGCTAGGAAC

123301 GCGCCTCTTT CCTCTCCCAT CACGCTGCAA GGCTTGGAGT CACTTCCGGC TGCAGGTCCC

123361 GGAACAAATC CGACCCCAGA AGTGGGGACT TCTGGCCCTC ACCTCCCCAT TTGAATGTAA

123421 TGTTTACAGT GATCCAGACC TGGGGATGCT TGCTTCCCGA CGTGTCCTGG GATCGCGCTT

123481 CTGAAAAAGC TCACCTCACA ACGCCTCCTC CGGACCTAAA TCGCGCACCA GTGAGTCGAG

123541 TCCTCCAGGG GCTAGAGAAG CCCGACTTTC TTTCCGGCCT TGAGGGACCC GGGCTCACCA

123601 AGAAACCAGC CGCCCTCCTC TCTATGGTTT TGGAGCCGGC GGAGAGCGCG CAAGGGTTGG

123661 CGGGACTGCG AGTTTCCGGT CTGGGCTTTG GCGGGTCTGG TTTGAAGCTC TCCTGTTTGA

123721 CGAAAGTATG TCTCAGGAAG GTGCGGTCCC AGCTAGCGCG GTTCCCCTGG AAGAATTAAG

123781 TAGCTGGCCA GAGGAGCTAT GCCGCCGGGA ACTGCCGTCC GTCCTGCCCC GACTCCTCAT

123841 ATCCTTCCTT GGTTGTCACT TCTACCTAGA GAAGGGTGTG GGCGGGTCGC GAACCTTTCT

123901 CTTCTGTCCC TTCAGACCCA CCGCCAGGCT GGGTTATATT ACCGCGGCCT GAACCCCCTC

123961 TTTTCTTTGT CAGTGAGTGG GATGAAAAGT GAGGGACTGG AGGGGAAGCG ACAACCGTGG

124021 TAGATTTAAG TAAGGCTTTG GCCCTGGAAA GCCTCGCGGA CGTGTTCTGA CCCAAGGTTT

124081 TAGCAGTGGA TGTGGCGTTT TCTTCCATTC CTTCTTTCAG TTTTTCTGTA CTCGTTGCTT

124141 GCAATTAAGT GTAAATACTT TTGCTAGTGG ATAATGGGGG AGGCAAGGAC TGAGACCTGC

124201 GGTATGACGA TAGCTCTGGC TCTTAATAGT TTGAGGTAAA GCGAGATACT CTGAGCTTTT

124261 GTCTCCCGTA AAAAGGGTGG TGAATATGAA TAAGGGCTTT CTTAGCGTTA TAAGAATTAA

124321 AGGGCATAGT TCTGTGGTGT GAAATCTTTA AAAGATGTTC AGTAAATAAA AATGATTTTC

124381 CTCCTTCCCC TCTCAGACCT CTTTTTCTTC TTTCTTTCTT TTTTTTTGAC AAGTTCTCAC

124441 TCCTCTCACC CAGGCTGGAG TCTTTCTGAA AGAGTTCTTC CGCTTGTTGT TGGCTTTCAA

124501 CTGTTGGATT TGAGGCGCT.T AGCGCCTTCT TCGTCCGGGT GCAGCACATT CTTGATTGGT

124561 CTCATGCCTT TGTGGTTGTA AATGTGCCTG GAATCCTAGC CTTTCATGGT AAACCATATG

124621 TATATGTATC TTTTTCACAA CATTTGAGCC CAGCTTTATA CAATTACACT CAAAAGAAAA

124681 AAAGTAACCT TCACTTGAGA GAATCTCAAT ACTGCACAAA TATTGTGCAG CTAAAGCCCT

124741 ATGTAATCAC ATAGAAGTCA TTCACCTAGG CATTAGCAAA ATCTCAGAAG GTGCCAAAGC

124801 CCCCTTTTTT AGTTTTTGTG TAGGTACAGA ACTGCCGTCT TCAAGGAGTT TCAACTTGAA

124861 AACAAATAGC CACCCTCAAA ACATTCAAAA ACACTTAAAC TGCGTGCATA ATGTGTGTGA

124921 GACATGGTGT TAGGCTTTGG GAGAACAGAG ACACGGAACG TGATTCCTCT TCTTCCCCAC

124981 AAGCTTATAG AGAGACTTCA TTAAGTTGAA AGTCAACATT CCCACCTAGC TTTGCACTTC

125041 AAACGACATA TTCAAAAAAG CCCAAACTTC CTCTAGTTTT CTTCATCTGA GTAAATGGTT

125101 TCACAAACTG AAACCTTGAA TCCTCTCTGT CTCACACACC CGATCAGTAA GTTCTATTGT

125161 TTCTGATTCC AAACTATGTC TTGAATCAAT CCGTTTATCT CCATCCTCAT TGCTACCACT

125221 CTGATTCCAA ACCCTTATCA CCTCTCACTT GGAGTATTAA TAGTTTCCTT GTTTCTACTC

125281 ATAATTCATT ATTCCAAAAA AGTTAAGAGG GGAAAAACAT AGATCTCGTC ATTTCCCTTT

125341 TTAAACCACT TTACCTTCAA GGTTCCAGGT GATCTAAGCC TTGCCCTTCT CTCATACCTA

125401 GTTAATTAAC TACACTCTGT TCATGAATAC ATTAGGCTCA CCTACCTCAA GATCTTTTTG

125461 CTCAGCCTGA TTTGTTCTCT CAGCCTTTTG CATATTTCAT GTTTATGTCT TGGCCCAAAT

125521 GTCACTTCCT TAGAGGGGCT TTTTCAGAGC CTTCAATCTT AGGCAGTTCC CCCAAACGCA

125581 GTCTTACACT TGTATCACAT TGGCCTGTTC AGTTTTCTAA AAAGCACATT ACCATTAAAA

125641 GAAATGCTCT TGTTTGCTTT GTATATTTTC CACTTCTACA CATTATGTTG CAAAGTTCAT

125701 AAAGGCAGGA TGTTGATTTT CTTCACAGCG TTACCCTCAG CACCTAGAAC AGTGCCTGAC

125761 ACATAGTAAG CATTCATTAA AGGGCTAAAA ATATTTCATG TTTTAAAAAT ACTTGGGAGT

125821 CTAATTAGAC AATACTTTTT TTCAGCTTAA TGGTAGTATT TTAGCTTCAC TATTTTAACA

125881 AATGAAAAAT TTGCAATAAA TCTACAATGC CATTACCCCC CAAAATCTTT TTCATGTTTT

125941 GCATTTTACG TATTATTTTC CAGGCCTTAC CTGCATGTCT GCATAATCAT AACTGACTAA

126001 TTTTGGAACA GCTGGTAATT ATTTGAGCTT TACTGAAATT TTTTCATGAG GCCAATTCTA

126061 CCCTACTGAA CTCAAATTTG AGTTAATGAT GACCTCATTT TGATTGCTGC TGTAAAAAAT

126121 AAGATTTCGG AAGAGGAATG AATTCTTGTA TTACTGTGGT AGGACTATGG GTTTTTTTTT

126181 GTTTGTTTGT TTGTTTTGAG ACGGAGTCTC ACCCTGTCAC CCAGGCTGGA GTGCAGTGGT

126241 GCGATCTCAG CTCACAGCAG CCAGGTTCAA GTGATTCTCC TTCCTCAGCC TCCCGAGTAG

126301 CTGAGATTAC AGGCACGTGC CACCATGCCC GGCTAATTTT TTGTATCTTT AGTAGAGATG

126361 GTTTCACCAT GTTGGCCAGG CTGGTCTCGA ACTCCTGACC TCGTGATCCG CCTGCCTCAG

126421 CCTCCCAAAG TGCTGGGACT ACAGGCGTGA GCCACCGTGC CCGGCCGGGT TATTCATTTT

126481 TCTTATTAAC ATTCTTTGAT GATTCTTATG GTGTTGTTAC AGTAAAACAT TTCTAACAAT

126541 TATTCTAACA ATTATTCTTG ATGGTGTATA TGAAGAATTT ATTGTCGTGT ATTTGTAAGC

126601 TGCTATGTGC AGAAGAATTT CAGTCAAATA AAGTTGGTAA GATAGGTATG TAAGTAATAT

126661 GAAAAAAGAT AGAAGGTGAT GAGTGACTTA GGTATAAATT AAGTACAATA GAAATGTTGA

126721 GGAAAGAAAA ATTTCTTGTA ATAGAAATCG GAAGTACAAA CTGGGCATGG TGGTGTGCAT

126781 CTCTAATCCC AGCTCCTTGA GAGGCTGGTA TGGGAGGATC ACTTTAGCCC AGGAGCTTGA

126841 GGCTGCAGTG AGGTGTGATC ATGTCACCGC ACTCCATCCT GGGTGACAGC AAGACCGTCT

126901 CTCTTTTTTT TTTTTTTTGA GACGGAGTCT CGCCTATGCT GGAGTGCAAT GGCGCGATCT

126961 TGGCTCACTG CAACCTCTGC CTCCCAGTTT CAAGTGATTC TCCTGCCTCA GCCTCCTGAG

127021 CAGCTGGGAT TACAGGTGTG CGCCACCATG CCCAGCTAAT TATTTTGTAT TTTAAGTAGA

127081 GACGGGTTCT CACCATACTG GCCAGGCTGG TCTTCAACTC CTGACCTCTT GTTCGCCCAT

127141 CTAGGTCTCC CAAAGTGCTG GGATTACAGG TGTGAGCCAC CCCACTTGGC CCCGAGCGAG

127201 ACCCTCTCTC TAAAAAAAAA TAAATAAATA AATCATAAAC CTGTGGATTA TTGTAGCATT

127261 GTTTCTCATC TGTCAAAAAT ATTTCATGAC TATGCATAGT TTGAAAAGGC AAGTTTGTCC

127321 CTGGGCAATT TTCAAAATAT TTCTTTAATG TGTTTTCACA ATACTGTTTA CCTAATAAAT

127381 CTTAAGTTTT TAAAAGCAAA ATTAAGCCAG TAATTTGAGT CCAATTCCAA TCTCTTATGA

127441 GTCATTGCTT AAATTTCAAA AGGGTTTTAT TTTTTTTTTA GGTTTGTTCT GAGTAATGAA

127501 TACCCTATTA CTATGATACT AGTATCTTCC TTAATTATCC TACTCATTGT CTCAACATTC

127561 TGACAGTTGG ATTGAGCATA TTCGTAAGTA AAATTGTTTT AACTGTATGA TGTACTTTGA EPI-109 642

127621 TGTTAAGGTC CGAGTCCCCA CATACCTCGG TAGATGTGTT CTTACAGTTT TGTATTCCCT

127681 TGAAATGTAA CTGTTCTGTA TGTTACAGCC TTTATAACCT TCAGTTACTT GAAATGAACA

127741 AATTCATTCA AATTCCAGCA CTTAAAAGTT TTAAATTACA TTTTGGATAA ATACCAAAGT

127801 GTTTTGTTGA TGATGTATGT ATAAACAAAT TGTAAATATT AAACGTTAGT TGTTACGATT

127861 AGACCTATAT AAAACATGAT ATGCAGTCTA CTGAATAGCT ATCAGCCTCT AACATGTTTA

127921 GTGTCATTTA GAAAATGCTT TCTAAATTGC CAAAAGCTGA TTGTCTAGGT GATAACAAAT

127981 TTACCATTTG GAGGAAGTTG ACTTTCTCAT TTTCATGTCT TCATCAGTCT TACTTGATGA

128041 GATTCATTCT TCTAGTCAGA AGAGAGTTTA GACTGCTCAG TTTACTCATA TTTTGAGTTA

128101 GCTTTTCTAT TTAGAGTTCA CTTGGTTGTG GAATATTCAT TTATAATTTG AATCTACGTT

128161 GTGTAATGGG ACCTAA TTT TTTTTCCTTT GTTTTTGTTG GAGTCTCGTT TTGTCACCCA

128221 GGTTGGAGTG CAGTGGCCTG ATCTTTGCTC ACTGCAACCT CCACCTTCCA GGTTCAGGTG

128281 ATTCTCCTGC CTCAGTCTCC CAAGTAGCTG GGATTACAGG CATGCTTCAC CACGCCTGGC

128341 TAATTTTTGT ATTTTTAGTA GAGATGGGGT TTCACCATGT TGGCCAGGCT GGTCTCAAAA

128401 CTCCTGAGCT CAAGTGATCC TCCTGCCTTG GCCTCCATAA GTGCTGGGAT TACAGGCGTG

128461 AGCCGCTGAG CCTGGCCCCA GAGTTTGTTT TGTTTTGTTT TCAAGACAAG ATCTCACTCT

128521 ATTGCCCAGG CTGGAGAGCA GTAGTGCGAT CATAGCTCAC TGCAGCCTGA ACTCCTGGGT

128581 TCAAGCTATT CTCCTGCCTC CATCTTCTAA AGTGCTGTGA TTACAGGTCT GAGCCATGAT

128641 GCTTGGCCTG TGTTTTTGTT TGTTTGTTTT GGGGGACAGG GTCTTGCTTT GTCACCAAAA

128701 CTGGAGTGTA GTGGTGCGAA CATAGCTAGC TCACTGCAGC CTCCATCTCC CACGCTCAAG

128761 CAATCCTCTC ACCTCAGCCT TCCAAGTAGC TGAGACCGCA GGTGCGTGCT ACCATGCGTG

128821 GCTAATTTTC TATTTATATA TTTATTTTTT GGTAGACATG AGGTCTTGTC ATGTTTCCCA

128881 GGTGGTCTTT AACTCCTGGG CTCAGACAGT CCTCCCGCCT CAGCCACCCA AAGTGTTGGG

128941 ATTACAGGCG TGAGCCACCA TGCGTGGCAT AATTTTTTTT AAGTAAATTA TTTTTTTATC

129001 TTGAGTATAG AAGTGATTCA TGTTCATTGT GGAAAATATG AAACATATAG AAAAACAGAA

129061 AAGATTACAA AACATCTAAT CTGAAATGGT TAAGATTTTG ATGAGAACAG TCTCATCTCA

129121 TTTCCGTATA TTCCTGCCAG CCTATCCATC ATTCTTCGTA CATGTTTATC TACATTAAAA

129181 TTGGTGTTAT ATTTTGGAAA CTTTTTGTTT AACTACATTG TGAACATTTT TCATGTTTTA

129241 AAATGTCATT TTAATGATGG CAGATCCTAT TCAATAGATG TACACACACC TATTTAACTG

129301 GTCCACAATT GTTGGATATG TAGGTCGTTT CCTTTCTCTC TTTTTTTTTT TTTTTGGCTA

129361 CTACTTAATA GTTTCTCTGT ATAGAATGTG GTATTTTGAA AGTGTATCAA GCTTTAGATT

129421 GGTAGTATTC TTGCATTTAA TAAAGGGCAG TGGCCTTTGT TGACTGACAT GACAATATTT

129481 TTATAAAATT TGTTATTTGC TTTACAGAAA TTTTGAAAAT TATTGTAGAA ATGTTTTTAC

129541 CTCATATGAA CCACCTGACA TTGGAACAGA CTTTCTTTTC ACAAGTGTTA CCAAAGGTAT

129601 AATACTATTA CCTGAAAATA CATGTTATAA GGAATCTAGC CTCAGTCTTA GATGATTTAT

129661 TATTAATTAT GGCTCTCTTT TTCTAATATA TCAAATATAT TCAAAATAAA AATAAGGAGT

129721 AAGTAGATCT CATGTGAGAC TATAATGGTG TTAGTGTGAT CATTAGGCAG TTAAAAACTG

129781 TTACAGGCTG GGCACGGTGG CTCATGCCTG TAATCCCAGC TCTCTGAGAG GCTGAGGTGG

129841 GCAGATCATC TGAGGTCAGG AGTTCGAGAC CACCCATGGT CAACATGATG AAACCTCGTC

129901 TCTACTAAAA GTACAAAAAA TTAGCTGGAC ATGGTGGCAG GTGCCTGTAA TCCCAGCTAC

129961 TTGGGAGACT GAGACAGGAG AATTGCTTGA GCCTGGGAGG CGGAGGTTGC ATTGAGTCAA

130021 GATCGTGCCA TTGCACTCCA GCCTGGGCAA TAAGAGCGAT GCTCCGTCTC AAAAAAAAAA

130081 AAAAAAAAAA AAGAACTTAT ATTTTCAGAT TGTGTGGTTC CTTTACTAAC TGAATTTAAA

130141 TTATTTGTAG TCAATTTTAA ATGCTCTTGT ATTTTAAAGC CACTGTACTC CAGCCTGGGT

130201 GACAGAGTGA AACCCTTAAT TCAAAAAAAA AAAAAAAAAA AAGAAAAGCT GGAATATTGG

130261 CAAAATCAAG TAACTAAGAG AAAACATTAA ATTCACAGAA TACATTATTA CATTTTAGAT

130321 ATATATGGTA TATGTTTTCT CTGAAAAGCA CAAGCATACC TTTTTTGTTT TAAATGGAGG

130381 GAACTAAAGA TACTTTGGTG CCAAAATGAA ACATTATTTG TAATTAATCT CTTATTGAAA

130441 TGGGTTTCTA ACTTTAGCTT TGAATCGTAA TCTTTCAAAT TTCTTGTACT CATAGTCACT

130501 TGATGATTCT CTATCTGAAA TATTTCTTAG AATTTGTTCT TGACCACCAG AAAAAGATTC

130561 AACTGTTACA TAGATGAAAA TGGATGTTGA GTGTTAACAG GCCTATGGGA AACAGTATTT

130621 TCTTTAGCTA CATTGTATTG TTGACTGTGT TGCTATTCTT ATAATGTTTA GGTCATTTAA

130681 ATTGTTAGAA AGATCCAAGT ATTAAGATCT AGGGTGGCTA ACTTTTCACA GACAAAAAGC

130741 TTGTTTGTAA GGTCATTTAC TATACCCTTA ATTCAGGAAG GTTAGCTTGA ATTGGGTCAA

130801 AAGGAAACTG GTTAGAAAAT AAGTGAGTAG TGAATAGGCG ATTCAGTGCA AATTCCTTCC

130861 AGAAAATACC CTTGTAAATG ACTGTATGAA TGTGGATTCT TCAAGACAGT CAAATTTATT

130921 GTGCGAAAGT AATACTTTTA TTTTTTGCAT CTCTAAAACA TGAACTTTGA GTGATTTTTT

130981 AAAAAAATTG ATGCTATTAA ATAGATTCAA ACCATAGAAA TGGAAAATAA ATTTCTGTTT

131041 GGGGCTTTTG GGGGGATTAT GTTGTAAAAA TACCTTTTCT CTGTATTTTG TGCTTAATTA

131101 GGTACAATTG TTAAGCTAGA TGATAGCCTG TGGATGTTAC TAGTGCAAAA TCAAATTATC

131161 GTATTGTGTT TTCTCTGTAA AGTTTTGTCT TGTCTTTTCT AGTGATTTCT CTTATTCCTG

131221 TTTATTACTT GATTTGTTTT TACAGACTGT GAAATTATTC GATGACATGA TGTATGAATT

131281 AACCAGTCAA GCCAGAGGAC TGTCAAGCCA AAATTTGGAA ATCCAGACCA CTCTAAGGAA

131341 TATTTTACAA GTAAGTCAAA TGTATTAGAA AGCAGGAGAG AGAGGGAGCT TAAAGAATGT

131401 CAAAATTTTT ATACTGATAC TGATTAGCTA TGTATTCTTA TGTAATGGCC TAATGTTGGA

131461 ATTAAATTTA TAGAATTAAA GACGTGAATA TAGAAACATG AATTCTGAAT AATAAACTCT

131521 TATAAGAAGA GAAGTCATCA AGCTAGCTGA CCCTACCTGT ATTTTCAAGG ATATGTGTGG

131581 AACACCTGCC ATGTGTTTTG AAGTTTGTGT TAGTATTCTA AATGGCTAGA CAGTTGTTCC

131641 AGTATTTGTA GTTCTGATAG ACTAAAGTTC TGTGAAAAGA GGAAGAGACT GTGTTTTGTT

131701 CATTGCTGTA TTTGTAGCAC CCAGCATGCT GACTAATACC TTTTCAGTGC ACAAAAAATA

131761 TATTCTAAGT GAAATTTCCT TCCTTATTCA CAGACAATGG TGCAGCTCTT AGGAGCTCTC

131821 ACAGGATGTG TTCAGCATAT CTGTGCCACA CAGGAATCCA TCATTTTGGA AAATATTCAG

131881 AGTCTCCCCT CCTCAGTCCT TCATATAATT AAAAGCACAT TTGTGCATTG TAAGGTGAGT

131941 AAAGGTCTAA TTATACTTTG AATGGTATAT AATCAATGTG CATAGGGGCT GAGTAAAATA

132001 ATGTTTGTAT AAGATTTTAC ATTTTAGTCT ATATTATTGA AATAAACTTT TCCATAGAAT

132061 AAAGAACATG TAAGTAAATA ATTGTTGCAA AAAAAGTGGT TTTAAGGAAG TCATTAAAAG EPI-109 643

132121 TGGCTTTTTG GGGTTTTTTA GTTTTATCTT ATTTCCCCTC TATAAAGAAA GAAGTTTTAA

132181 GAATTTGTGT TGAGACACAC ACAGGGATCC TGAAATAGTT ATGTCATGTT GCATTGACCA

132241 ATATTCAATT ACCATTATGA TTAGATGTCA GAACTTCCTT TTATAAAGGA AAGTTAATCC

132301 TTATTTAGTC CATCTCTACA TGCCAGAGGT AGCCTTGAGG CACAAAAGCT TGCCTAGAAT

132361 TTATGGGTCA CAGACAGTTT TAATATTGCT ATTTGTTGGG CGAATGAAAA TCACTAGTTA

132421 ATTAATACCT CTCTTTGCTG ATAGGATGCT AAAAATGTCA CGCACCTGGC CTAATGTTAC

132481 CCTTTTTTAG TTCTGTATTT GCAAGATCAT GGAAGTCAGA AATAATATTT TATACATGCT

132541 TGCATCTCTT GAAGCACACT ATATTTAATG GATGTTCACT AAACAATGAA TGAATATGTG

132601 ATTCAGTAAA TTTATGATCT CTAATAGTAT GAATTAAAGT AAATTTGGCT CTTGAGCTTT

132661 GATTTGTTTT TTCTCTCATT TTTATTTATC CGTAATCAGA ATAGTGAATC TGTGTATTCT

132721 GGGTGTTTAC ACCTAGTTTC AGACCTTCTC CAGGCTCTTT TCAAGGAGGC CTATTCTCTT

132781 CAAAAGCAGT TAATGGAACT GCTGGACATG GTTTGCATGG ACCCTTTAGT AGATGACAAT

132841 GATGATATTT TGAATATGGT AATAGGTGAG TGAAGAAAAC TTTCTGCTTA GTATATGGTG

132901 ACTATAAATC ATGTATCAAT TAAAATTGTC TCTAATGATT CATGTTATTT TCTTACTAAT

132961 TATGCATTAA AATTGATTTA AATCTTACCA AATAAATTTT TAATCTTGAA ATTTGGAATT

133021 TGTAAAATTT ATTTTGGGTA CCTTAACCTA GATTTGCGTA TTTAGTTACT GTAATTTCTC

133081 CACAATGATT AACTTATATA ACTTTATAAT CTCTGAGGTT GTCCATATTC AGAGACAATA

133141 ACTTTCACAT TTTTTTAACC ATAACTGATA TTGAGATGCA GTTTATATTT CCTTCCAGAA

133201 TACATATAAA TACGTGCATA TGTGTATGTA AATATGTCTA TTCTCATATA CATATTATAA

133261 TGAAATAACT CATTTTACAT GTGATGCACT TTATACTAGT TTATTTTTAT TTTATTTTAT

133321 TTTTTTGAGA CAGAGTCTCA CTGTGTAGCC CAGGCTGGAG TGCAGTGGCA CAATCTCGGC

133381 TCACTGCAAC CTCGCCTCCC GGACTCAAGC GATTCTCCTG CCTCAGCCTC ATGAGTAGCT

133441 GGGATTATAG GCGTCCGCCA CCACACCTGG CTAATTTTTG TATTTTTAGT AGAGACAGGG

133501 TTTCACCGTG TTGGCCAGGC TGGTCTTGAA CTCCTGACCT CAGGTAATCC ACCTGCCTCA

133561 GCCTCCCAAA GTGCTGGGAT TACAGGCATG AGCCACCGTG CCCAGCCAAT ACTAGTTTAT

133621 TTTTAAAGAA TTGCTGGTCG TAACACACTT CATTGATTTT ATCACTCATT AATGGATTAT

133681 GAACAAGAGT TTGAAAAACA ATATAAAGGC AAAGTTTGCA TTCAAAACTT TGGTATAAAG

133741 AGAGTAAGTT GGTTTTGTGC AGTGTATCAG GCACCTGTTG CTCTGCAACA CACCACCTCA

133801 AAATCTATTT ATTCACTATT TATTTATTCA TGATTCTGTG AGTCTGCAGT TTAGGGTGGG

133861 ATGTCCTGAG ACAACTTTCT CTGATCCACC TGGGGCACTA GCTCACCCAT GTGACTTCAG

133921 TGACTTCATT CACATCTGGC TGTTGGCAGA GGCAGAAGTA CTTGAGAAAG CCATGTGCAT

133981 CATCCAGCAG GTTCACCCTA TCTCAGATAC CTGATGCCAG TGGTTTCAGG GTTTCTAAGA

134041 GTAGCAAAAG TGTGAGCAGG TCGCTGTGTG CTAGCACTTT TCAAGTTTCT GCTTGCCTTA

134101 ATTTTATTAT TGTCCCCCGG GCCACAGCAG GTCATAGCGT TTAGCCCAGA GTCATTGTAG

134161 AAAAGTGTGG ATTCACAAAG GGCAGTCATT GTGGCCATTT TTATAAATAA TCTACCACAG

134221 ACTGAGTAAA AGCCTTGCAT GAATACCATG GATATTAATT TGAATTCTTC CTTTTTAGAT

134281 TTTCTTTCCT TAGCAATTTG TTTTGTCATT TTGGATTAGA ATTATATCTG TAGAATATTT

134341 CAGTTATAAT AGGGTACAAC TTTTATTCCA CTGAACATCT TTAGTTTTAT TTAGGTCATC

134401 TGGTAGGTAT AAACTTCAGA AGTTAATATT CAATATTTAT AAAAACCATT AACAAGTGTG

134461 ACACTTAAAT AGTTTAAATA ATTCTTTTGA CACAACTGTT TCCAAGTTGT GTTACGTATT

134521 TTAATTCAAT CAAATGTTGA AATTGTTCAG TAGATAGTTT TAATTATAGG AGAAACTCAC

134581 CCCCATGACA TTTGGATGTC TTAAAAGTTC TGTTATCTTT CTTTGCAGTT ATTCATTCTT

134641 TATTGGATAT CTGCTCTGTT ATTTCCAGTA TGGACCATGC ATTTCATGCC AATACTTGGA

134701 AGTTTATAAT TAAGTAAGTT TGTTTGTTAT TTTTTACTTT TTAGAAAATG TTTTCCATAT

134761 TCCCCAATCT TAATTATTCA TGATTCTTTA GATTGCATTT AAAACATTTT GTGTGAATTT

134821 AATGTTCACT GACACTGCTG TCTGATAATC CAGATATTCT ACATGTAGCT CTCAAGCCAA

134881 ATTGGACTTC TTTACCCTGT GGCCTCTAAA ATTAAAAAAA ATGTTCTTCC TAGTTAGCTA

134941 GTACTTCAGA AATAATGGGC CATGGGCCAG ACTAGAACTT AACCACTTTT CTTCTGCTAC

135001 TGTTGTTTAA CCAGCTATCA AGTATCCTAT TTCTAGGATT AGATAAATTG ATAACTATAA

135061 TTAAAACTGA ATATAATCTT TTCATTAGGT ACTTTTAAGT TGTTCACACT TAATTCCATT

135121 TGTACAGTAA TTTTAACTTT CTGAAACTGA AGCATTTTAA AGGGTCACCA GGGATAGTGC

135181 CTGTAGCATT CATCAGATTC TTAGGGGTGA GAGGAGATGT GGTTGAGATG TAAAAATGGT

135241 TAAGAATATC TACTTTATAC ACATACATAA AACATTAAAG GTCAGTGTAT TTTCAGGTCT

135301 TAGGTACTTT TCTTGTACTA CCAGGACATT AAGTTGCCAT TCAGTGGTTA AGAGTGTTGC

135361 CTGGGAGCTG TATCACATGT GCTTAAATCC ATTCTTGAAA TCATTTACTC CTTCTGAGCC

135421 CTTGGGCTAT TTGGTTAATT TCTCTGAACG TTAGTTTGCT CATCTGAAAA TGGAAATAAT

135481 AATAGCAACT TCTTGACAGG GTTATAGTGA GAATTGAGTT CATCACTGTG AAATGCTTAG

135541 AAATGTGCAT GACACATAGT TAATACTCAA GGAATTAGCC ACATCACTAT CATCATCACT

135601 GATTATCTTC CACTCTTACC CTCTTCCAGT TCATTTTCTG CCCAGCAGAA TGATCTTTTA

135661 AAAAGTAAAT CAGATCATGT TACTCTATTG CTTGAAGTCT ATCCCATTTG ATTAAGAATA

135721 ACAACCTAAT CCTCTGTGGA TGCTGCCTCC TTCACCAGCC TGTCTCATGC TGCTCTCCCT

135781 ACTCTTAGTT CCTCAAACAT ACCAAACTCT CCTGTCCCAG AGTCTTTTCG TGGTTTTTCC

135841 ATCTGCCTAG GATGCTTCTC TCTCCTATTT TGTGTACCTT GCTAACTCCT GCTTACTGTC

135901 TTTCAGTTCT CAGCTTAAGA GTTATATCTT CATGATAACA TTCTTTGATA TCCTTACCCT

135961 AAGATTAAGT TAGATTGATA TCCTTACCCT AAGAATAAGT TAGATTAGGT CTCTCTATTG

136021 TAGCACCTTA GACTCTGTCA TTTGACAAAT CACAGCCCTA ATTAATTATT CTTAAAATTA

136081 TTTAACATTC TCTCTCATGC TAGACCACAA GTTTCATGCA GGTAAGGCGG AGATTGTGTC

136141 CATTTGTTTG ACCCCTTTGT CTCCAGGGCC TGGTAGAATG CCTCATACAT AGTAAGAATT

136201 CAATTAATAT TTTACACAGA GAAAAAATTA GCAACTTATT TAAACAAATA TAACTGCTTC

136261 AGAGGTAAAC TGGGCACATC TTAGTTATAT TATGTGATAT ATGATGCTTT TTGATTGTTT

136321 TTTTAAATGT TCTACAAGGT AGATATTGTT AGAGGTCCTA AGTTACTTGA TGTGTTACTT

136381 GTGGTGATTG TATTCTTTTC TTTTTATTCA TTTAGGCAGA GCCTTAAGCA CCAGTCCATA

136441 ATAAAAAGCC AGTTGAAACA CAAAGATATA ATTACTAGCT TGTGTGAAGA CATTCTTTTC

136501 TCCTTCCATT CTTGTTTACA GTTAGCTGAG CAGATGACAC AGTCAGATGC ACAGGTAAAA

136561 TTTGGGCTAA TAGCATTTTA AACAGCAACT CTTATTTTCT TTGGCAGTTA GTAAATCTCA EPI-109 644

136621 TTTGAATGTC TGGGTCAGTC TATTTAAGAG GATTTTAATT TATTTCATTT GGGTGTTTTT 136681 TTTTGATCTG TGGGATTATT TATATCCCAT AATTACTTTT CACCCAGAGC ATTGTATTAG 136741 ATTCCTAACT GCTGTCATTG CCTCTGGGGT CTGCCTGGCT CCCTCTTTGC TTGGTAACTG 136801 GTTGGTCACA GCATTCTTCT CAGAATCCTT TCATTCTTTT CTGCATGAGA ACAAAAATTC 136861 TTTTGTTCAT ATTTGTATAA GATCTGATAT AGCTGCAATC AATCTTGCAT TTTTTCTTCA 136921 CCAACGCATT GCGACCTTTA GGGATACAAG TATGTTTGTG CATGTATATG TATGTATCAG 136981 TCTTTTAAAT TTGATATAGT CATACATTTG TTTTTATTTT GAAAAGTTAG AGTGTTGAAT 137041 TGGTATCCCA TTTATGAAAC ATTATATTCT AAAAATTTGT AGTACGATTA TTGGGAATTA 137101 TAACTCATTT TCCTGTAACA CTGTTATACA TAGTACCTTT TGCTTTCAGA CTAGCCCTCA 137161 ATTTTATTTA ACTATAGTAG TCCTAAATTA TAAGATTAAT AGTACTCAGG ACCTAACAGT 137221 TATATGTCAT TTGTTTTTTT TTTTTTTGAG ATGGCGTCTC ACTCTGTCAC CCAAGCTGGA 137281 GTGCAGTGGT ATGACCTTGG CTCACTGCAG CCTCTGCCTC ACGGGTTCAA GGGATCGTTC 137341 TGCCTTAGCC TCCTGAGTAG CTGGGATTAT AGGCGCCTGC CACCACGCCT GGCTAATTTT 137401 TTTAGTAGAG ACGGGGTTTC GCCATGTTGG CCAGGCTGGT CTCGAACTCC TGACCTCAGG 137461 TGGTCCACCC GCCTTGGCCT CCCAAAGTGC TGGGATTACA GGTGTGAGCC ACCGCGCCCA 137521 GCCTATATGT AATAATTTTA ATGGGACCAT GAATTGAATA TTTCTTCCTT GAATAGCAAT 137581 GACATAGCCC CTTCTATTGT ACATCTGCAA GCTGATACAG GGAATTCCTT TGTACCTGCG 137641 CTCTTCCCTG CCAGTCAGCT ATGGGGGTGA AAGTGTAGGG GTTCATCCAA GTCCTAAAAC 137701 TGGTAGCAAC TCCTAGGGCA GGGCTGATCT GGAAGGACAG ACCCTAGGGG AGGGTGGAAC 137761 TTTAAAAAGA AGTTCTGAAG GTAGTAAGAA GGAAATGAGG AGTAGTGTTA GGAAGGGGCT 137821 AACTTTTTTC TTCTTGCTTC TCTTCTTTAT CTCACCTGCC CCTCCCCTTG TATCCCTTCT 137881 TCCTTTTTCC CTTTCCTTTT TTGTCCTCAC TTCATTCGTG CATCCTTTCT GATTCCTCTT 137941 ACCTTGCTAA AAGGAGAAGT TTGTTTGGGT ATCCTATATC AATGGCAGGA AGGTTGTTTT 138001 CTTCTTTACC TTTATCCTAT AGATTCATAT TCTCAACACC AACCTCCTCC TTTTTCAGTT 138061 TCCTTCTTGC TTCTCTTGAC ACCACAGAGT TTGCAGCTAG TACTTGGAGA GGAAAATTAA 138121 ACAGAGATAC TTGGACCAAG AGTAAGATGA AGAAAGTCTA AACAACAGTA TAGTCTATAG 138181 TGGCAAGAGA GAGTATGGGG GCTGCTTAGC CAGGGTGGCT GTACATAAAG TATATCTTCA 138241 GTTTATATAA ACTGCTTATA GATGGAAATC AGAAAATTTA AATTCTCTTA ACTGTCCAAG 138301 AAAATTCTCA TTTTTTCAAA TTTGGGACTG ATAAATGTGA CCAGTTCTGC TTACTGTCCA 138361 TTGCCTGAAA TGGAGCTTTG AGGTGGACTG TATAATTTCT TCAATCTTAA CTCCAAATTC 138421 TGATCAGCGA CGCCCTCTGC TGTTCACTAT TAATATTTAT TTACCAATCA AAGTAAAGTA 138481 TTGAAGTTTT CCTGGCAGTT TTCACTTTGT GTTTTAGTCC ATTTAGGCTG CTATAACAAA 138541 ATCCCTTAAA CTGGGTAAGG GATTATAAAT ATTAGAAATT TATCTCTCAC AGTTCTGGAA 138601 GCTGGGAAGC CCAATATCAA GGCACCAGTA GATTTGGTGT CTAACGAGGG TGTGCCGTCT 138661 GCTTCAAAAA TGGCCCCTTG TTGCTGCATC CTCACTTAGT GCAAGGGGCA AGACAGCTCC 138721 CTTCAACCTC TTTTATAAGG GCACTTATGT CATTCATGAG GGCAGAGCCC TCATGACTTA 138781 ATCACTTCCC CAAAGGCCCC ACCTCTTAAT AGTATCACAT TGGGTGTTAG GTGTCTGGGA 138841 GGACACCAAT CTTCAAGCCA TATCATCTCA CTTGGAAAAA AGTCAAAATA AAACCAGTAG 138901 ATTTAATTAA TATTACACTA TTTATAGAAG CATGTGATGT ATCATTCCTT GTATTAATTT 138961 CCTGGGGTTG CCGTAACAAG TTACCACAAA CTAGGTGGCT TAAAACAATA GAATTTTATT 139021 CTCTCACATT TCTAGAGGCA GAAGTTCACA GTGTGTCAAT AGGGCCATGT TCTCTGGAAG 139081 GCTTTAGGGG AGAATATATT TCATATCTTT CTCTTAGCTT CTCGGTGTCA CTGGCAATCC 139141 TTAGCTTACT TTGGCTTTCT GTGTCTTCAC ATCATCTTTT TATAAGAACA CCAGTGATAG 139201 TGATTAAGGG CATACCTTAC TTTAATATGA CCTCATCTTA ACTAATTATG TCTTCAATAA 139261 CCCTATTTCC AAATAAGGCC ACATTCTGAA GTATTGGGAG TTAGAACTTA AAGCTTTTTG 139321 GGAGGGACAC AGTTCAACCC ATAACAACCC CTAAAATCGA TATTTATTCT CAATTAAGTC 139381 TTGAAATTGG TTTCAAAAAG AGAATATTCT ATTAGAGTTT TTAATGTATA GTTTTAACAT 139441 ATAGTTCTTT AGCCCCCAAT TTTTTTTTTT TTTTTTTTTT TTTTTTTTTT TTTTTGAGAC 139501 GGAGTCTCGC TCTGTCGCCC AGGCCGGACT GCGGACTGCA GTGGCGCAAT CTCGGCTCAC 139561 TGCAAGCTCC GCTTCCCGGG TTCACGCCAT TCCCCTGCCT CAGCCTCCCG AGTAGCTGGG 139621 ACTACAGGCG CCTGCCACCG CGCCCGGCTA ATTTTTTTGT ATTTTTAGTA GAGACGGGGT 139681 TTCACCTTGT TAGCCAGGAT GGTCTCGATC TCCTGACCTC ATGATCCACC CGCCTCGGCC 139741 TCCCAAAGTG CTGGGATTAC AGGCGTGAGC CACCGCGCCC GGCCTGCCCC CAATTATTTA 139801 GTTTTTCTAT AAACAGGGAA ATTTATTTGT GTGGCCCTTA GAACTAATTT AATTTCCACT 139861 CTAATTCCTA CTTATGTTTA TATAATGCTT TTAGAAATTT GTATTATTCA GAAAATAAAC 139921 ATATACTATT GTATCTGTTG CCTACACTTA GATTTTATTG CCTGCTATAT TTAAATTTTA

139981 TTAGTATTTT AATTGTTTTA TTAAAGAAAG AATGTGCCTG TAATCTCAGC ACTTTTGAGA 140041 GGCCAAGGCA GAAGGATTGC TTGAGCCCAG GAGTTTGAGA CCAGACTGAG CAACACAGGG 140101 AGACCCCCAT CTCTACAAAA AATAAAAAAA TTCTCCAGGC CTCATGGCAC ATACCTGTAG 140161 TTCTAGTTAC TTGGGAGACT GGGGTGGGAG GATGCATTGA GCCCAGGAGA TTGAGGCTGC 140221 AGTGAGCCAT GATCAGGCCA CTGTACTCCA GCTTGGACAA CAGAGTGAGA GCTTGTCTAG 140281 ATAGATAGAT AGATAGATAA TCTAAATAGA TAATAGACAG ATTATCTAAA TAGATAATAG

1403 1 ACAGATTATC TAAATAGATA ATAGACAGAT TATCTAAATA GATAATAGAC AGATTATCTA 140401 AATAGATAAT AGACAGATTA TCTAAATAGA TAATAGACAG ATTATCTATC TAAATAGATA 140461 ATAGATTATC TAAATAGATA ATAGATAGAT AGATTAGATA GATAGATAGA TAGATAGAGC 140521 TTGGACAACA GAGTGAGAGC CTGTCTAGAT AGATAGAAAC AAAGAAAGAA AGAAAGAATG 140581 GTGCTCATAT TTTAAAGCAT TGAAAAATGG TCTTCCTTGC TTATATTACC CACACCTTCT 140641 TTGTTGGCAT TAAGATGCAA ACTTTGTTTT AAACAGTTGA GTAAATCAAA GATGGGACTG 140701 TTAAGTTATT TGTGTTATTT ACCTGCTTTT TGAAAATGTA AAAATAAAAC TCTAGGTTTA 140761 ATTAGTAGTA TGCTATTTAG TAATGAAGTA AAGCTAGAGG CTTCGAACAA ATCTTGTGTA 140821 ATTTCCTCTT GAATGAGAGA GAAAATTTAA AGTAAGCAAA CAAATAAGTT GTGTGTCACC 140881 ACTCATTCAG TCATTTAACA AGTATTTCCA GAGTACTTAT TCTGTGCCAG GAAATGTTGT 140941 AGGTGCCCTC AACAACTTAG AGTCTAGCCT GAGACACAAG TAAGTAGGTA ATTATTATAG 141001 AATGGTATGA TCTTTGGAGG ACTGGGTATT GGCTGGCTCA TGGGAGTACA AGATAGGTAC 141061 CCAGTGATGA AGTCAGGAAA GGTTTCTTAT GGTGATATGA TGACGTCTAT GCTGATTATA EPI-109 645

141121 AGGTCAGTGT AGAATAAACT TTGTGCTTTT AAATTTGCAT AGCACTGTAT TAGAGAGTTC 1 1181 ATCTTCAAAA TAATCGAAAA GGCTGAGTGT GGTGACCCAT GGCTGTAATC CCAGCACTTT 141241 GGGAGGCCGA GGTGGGCAGA TTGCTTGAGC TAGGAGTTCG AGACCAGGCT GGCCAACATG 141301 GTGAAACCCC GTCTCTACTA AAAATACAAA AATTAGCCAG GAGTGATGGT GCGCACCTGT 141361 AATGCCAGCT ACTTGGGAGG CTGAGGCAGG AGGATCACTT GAACCCAGGA GGTGGAGGTT 141421 GAAGTAAGCC GAGGTCATGC CACTGCACTC CAGCCTGGGC AACAGAGTGA GACTCCATCT 141481 CAAAAAAAAA AAAAATGATC AAAGAAAGGT GAATTTTCAT CTACCCTATT TCTGCTGAGG 141541 AAAATGGACT ATTTTCAAAT ATTTTTAATA AGGGTCAAAA TGAGGGATC

(2) INFORMATION FOR SEQ ID 0:2481: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1261 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2481:

1 GCCACCATGG AAACCCTTTG CCTCAGGGCA TCCTTTTGGC TGGCACTGGT TGGATGTGTA

61 ATCAGTGATA ATCCTGAGAG ATACAGCACA AATCTAAGCA ATCATGTGGA TGATTTCACC

121 ACTTTTCGTG GCACAGAGCT CAGCTTCCTG GTTACCACTC ATCAACCCAC TAATTTGGTC

181 CTACCCAGCA ATGGCTCAAT GCACAACTAT TGCCCACAGC AGACTAAAAT TACTTCAGCT

241 TTCAAATACA TTAACACTGT GATATCTTGT ACTATTTTCA TCGTGGGAAT GGTGGGGAAT

301 GCAACTCTGC TCAGGATCAT TTACCAGAAC AAATGTATGA GGAATGGCCC CAACGCGCTG

361 ATAGCCAGTC TTGCCCTTGG AGACCTTATC TATGTGGTCA TTGATCTCCC TATCAATGTA

421 TTTAAGCTGC TGGCTGGGCG CTGGCCTTTT GATCACAATG ACTTTGGCGT ATTTCTTTGC

481 AAGCTGTTCC CCTTTTTGCA GAAGTCCTCG GTGGGGATCA CCGTCCTCAA CCTCTGCGCT

541 CTTAGTGTTG ACAGGTACAG AGCAGTTGCC TCCTGGAGTC GTGTTCAGGG AATTGGGATT

601 CCTTTGGTAA CTGCCATTGA AATTGCCTCC ATCTGGATCC TGTCCTTTAT CCTGGCCATT

661 CCTGAAGCGA TTGGCTTCGT CATGGTACCC TTTGAATATA GGGGTGGACA GCATAAAACC

721 TGTATGCTCA ATGCCACATC AAAATTCATG GAGTTCTACC AAGATGTAAA GGACTGGTGG

781 CTCTTCGGGT TCTATTTCTG TATGCCCTTG GTGTGCACTG CGATCTTCTA CACCCTCATG

841 ACTGGTGAGA TGTTGAACAG AAGGAATGGC AGCTTGAGAA TTGCCCTCAG TGAACATCTT

901 AAGCAGCGTC GAGAAGTGGC AAAAACAGTT TTCTGCTTGG TTGTAATTTT TGCTCTTTGC

961 TGGTTCCCTC TTCATTTAAG CCGTATATTG AAGAAAACTG TGTATAACGA GATGGACAAG

1021 AACCGATGTG AATTACTTAG TTTCTTACTG CTCATGGATT ACATCGGTAT TAACTTGGCA

1081 ACCATGAATT CATGTATAAA CCCCATAGCT CTGTATTTTG TGAGCAAGAA ATTTAAAAAT

1141 TGTTTCCAGT CATGCCTCTG CTGCTGCTGT TACCAGTCCA AAAGTCTGAT GACCTCGGTC

1201 CCCATGAACG GAACAAGCAT CCAGTGGAAG AACCACGATC AAAACAACCA CAACACAGAC

1261 CGGAGCAGCC ATAAGGACAG CATGAACTGA CCACCCTTAG AAGCACTCCT

(2) INFORMATION FOR SEQ ID NO: 2482: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1861 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2482:

1 GAATTCGGGA AAAAGTGAAG GTGTAAAAGC AGCACAAGTG CAATAAGAGA TATTTCCTCA

61 AATTTGCCTC AAGATGGAAA CCCTTTGCCT CAGGGCATCC TTTTGGCTGG CACTGGTTGG

121 ATGTGTAATC AGTGATAATC CTGAGAGATA CAGCACAAAT CTAAGCAATC ATGTGGATGA

181 TTTCACCACT TTTCGTGGCA CAGAGCTCAG CTTCCTGGTT ACCACTCATC AACCCACTAA

241 TTTGGTCCTA CCCAGCAATG GCTCAATGCA CAACTATTGC CCACAGCAGA CTAAAATTAC

301 TTCAGCTTTC AAATACATTA ACACTGTGAT ATCTTGTACT ATTTTCATCG TGGGAATGGT

361 GGGGAATGCA ACTCTGCTCA GGATCATTTA CCAGAACAAA TGTATGAGGA ATGGCCCCAA

421 CGCGCTGATA GCCAGTCTTG CCCTTGGAGA CCTTATCTAT GTGGTCATTG ATCTCCCTAT

481 CAATGTATTT AAGCTGCTGG CTGGGCGCTG GCCTTTTGAT CACAATGACT TTGGCGTATT

541 TCTTTGCAAG CTGTTCCCCT TTTTGCAGAA GTCCTCGGTG GGGATCACCG TCCTCAACCT

601 CTGCGCTCTT AGTGTTGACA GGTACAGAGC AGTTGCCTCC TGGAGTCGTG TTCAGGGAAT

661 TGGGATTCCT TTGGTAACTG CCATTGAAAT TGTCTCCATC TGGATCCTGT CCTTTATCCT

721 GGCCATTCCT GAAGCGATTG GCTTCGTCAT GGTACCCTTT GAATATAGGG GTGAACAGCA

781 TAAAACCTGT ATGCTCAATG CCACATCAAA ATTCATGGAG TTCTACCAAG ATGTAAAGGA

841 CTGGTGGCTC TTCGGGTTCT ATTTCTGTAT GCCCTTGGTG TGCACTGCGA TCTTCTACAC

901 CCTCATGACT TGTGAGATGT TGAACAGAAG GAATGGCAGC TTGAGAATTG CCCTCAGTGA

961 ACATCTTAAG CAGCGTCGAG AAGTGGCAAA AACAGTTTTC TGCTTGGTTG TAATTTTTGC

1021 TCTTTGCTGG TTCCCTCTTC ATTTAAGCCG TATATTGAAG AAAACTGTGT ATAACGAGAT

1081 GGACAAGAAC CGATGTGAAT TACTTAGTTT CTTACTGCTC ATGGATTACA TCGGTATTAA

1141 CTTGGCAACC ATGAATTCAT GTATAAACCC CATAGCTCTG TATTTTGTGA GCAAGAAATT

1201 TAAAAATTGT TTCCAGTCAT GCCTCTGCTG CTGCTGTTAC CAGTCCAAAA GTCTGATGAC

1261 CTCGGTCCCC ATGAACGGAA CAAGCATCCA GTGGAAGAAC CACGATCAAA ACAACCACAA

1321 CACAGACCGG AGCAGCCATA AGGACAGCAT GAACTGACCA CCCTTAGAAG CACTCCTCGG

1381 TACTCCCATA ATCCTCTCGG AGAAAAAAAT CACAAGGCAA CTGTGAGTCC GGGAATCTCT EPI-109 646

1441 TCTCTGATCC TTCTTCCTTA ATTCACTCCC ACACCCAAGA AGAAATGCTT TCCAAAACCG 1501 CAAGGGTAGA CTGGTTTATC CACCCACAAC ATCTACGAAT CGTACTTCTT TAATTGATCT 1561 AATTTACATA TTCTGCGTGT TGTATTCAGC ACTAAAAAAT GGTGGGAGCT GGGGGAGAAT 1621 GAAGACTGTT AAATGAAACC AGAAGGATAT TTACTACTTT TGCATGAAAA TAGAGCTTTC 1681 AAGTACATGG CTAGCTTTTA TGGCAGTTCT GGTGAATGTT CAATGGGAAC TGGTCACCAT

1741 GAAACTTTAG AGATTAACGA CAAGATTTTC TACTTTTTTT AAGTGATTTT TTTGTCCTTC 1801 AGCCAAACAC AATATGGGCT CAAGTCACTT TTATTTGAAA TGTCATTTGG TGCCAGTATC

1861 CCGAATTC

(2) INFORMATION FOR SEQ ID NO: 2483: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 721 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2431:

1 CACCGCTCCT GTCAGCCAAC AAATATCCAT TGAGCGACAC CTGTGTCCCA GGTGCTGCTC

61 TGGGCCCTGG GAGAAGTGCA TCAGTGGGCT TGGTAGTAGA GGGTAGGGAT GGAGTGAAGG

121 GTAGGCAGGA AGAATGTGCC CAGGCTGGTA GGAGGTGGGG TGGGGGGTTT CAGTCTCAAA

181 ACTCCCATGA AAACCAGAGA GAAGTTTCAG AACTCCACCC AAGAGGCTGG GTTTCTAGGG

241 CCCAGAGCTG CCCTCCCCCA CCCTAGAATG GGCTATAAAA GTCCCTTCCC AGCTACGTCC

301 AGAGAAGAGC TGGAGGAAGT GAGAGGTCGG CTGGGGGTCC TCAAAGTGAG AGGGGAGCAG

361 AGGATCCTCC CGTGCAGGCT GTGGATGTCA CTCACTTCCC AGCTGGTGAA GCCTCGCTGC

421 AGAGATGCAT CTGCTCCCAG CCCTGGCAGG GGTCCTGGCC ACACTCGTCC TCGCCCAGCC

481 CTGTGAGGGC ACTGACCCAG GTAATAGTCC CCTAGACAGG CAAGGAGGAG GGAGGGGAAA

541 TGGAAGGGGA AGCACTTGGG TCTTGGAGGG GGTCTTGTGG CTTGCTGAAC CCTGAGTCCC

601 CATCTCTTTG AACAGCCTCC CCTGGGGCAG TGGAGACCTC GGTCCTGCGA GACTGCATAG

661 CAGAGGCCAA GTTGCTGGTG GATGCTGCCT ACAATTGGAC CCAGAAGAGG TGGACTTGGG

721 TCTGGGGGCT GCATGGGCCT GGGAGGATCA GT

(2) INFORMATION FOR SEQ ID NO:2484: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 361 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2484:

1 TAATACCTTG TGGGGTCAGG GAGCCCATGT CCCGTGCTGA TGTTATTTCC CCACCAGGTC

61 CGGGCTGTCT CCAACCAGAT TGTGCGCTTC CCCAATGAGA GACTGACCTC CGACCGTGGC

121 CGAGCCCTCA TGTTCATGCA GTGGGGCCAG TTCATTGACC ATGACCTGGA CTTCTCCCCG

181 GAGTCCCCGG CCAGAGTGGC CTTCACTGCA GGCGTTGACT GTGAGAGGAC CTGCGCCCAG

241 CTGCCCCCCT GCTTTCCCAT CAAGGTACCT ACCCTCAGCC AATCTCCCAT GCCCTTGTGT

301 GGCCTCCCCC AAAGGCAAGG TGCTGGGGGT GGGGATCTGG AAGACTGGAG CACCATCCTT

361 AAGGAGCTGC CTGTGGAGCT AGGGTATGAG ACAGAGACAC AAG

(2) INFORMATION FOR SEQ ID NO:2485: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 481 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2485:

1 CACTGTCTCC TCTTCCATCT CAGATCCCAC CCAATGACCC CCGCATCAAG AACCAGCGTG 61 ACTGCATCCC TTTCTTCCGC TCGGCACCCT CATGCCCCCA AAACAAGAAC AGAGTCCGCA 121 ACCAGATCAA CGCGCTCACC TCCTTTGTGG ACGCCAGCAT GGTGTATGGC AGTGAGGTCT 181 CCCTCTCGCT GCGGCTCCGC AACCGGACCA ACTACCTGGG GCTGCTGGCC ATCAACCAGC 241 GCTTTCAAGA CAACGGCCGG GCCCTGCTGC CCTTCGACAA CCTGCACGAT GACCCCTGTC 301 TCCTCACCAA CCGCTCGGCG CGCATCCCCT GCTTCCTGGC AGGTCAGACA GGGAGGAAGG 361 TGGTGTCTTC CCAGGAAACA GCCATCCCTG GGGTCCCAAC TGGGAAGCAA TGGTGGGATG 421 TGGTGAAGGT ACATGGTTTG GGACCTCAGT ATTAGGCACA CCATAAGCAT GGATCTGTGC 481 AC

(2) INFORMATION FOR SEQ ID NO: 2486: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 301 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2486:

1 TGAAGAGATG GAGGTCCAGT GAGGGCCAGG AGTTTGGCCC ACCCCGTCTC TCCCATCCCC EPI-109 647

61 AGCCCTGGGT CTACCCTGGT AGAAAGACAT TTCTCTGGGA AAGGCTGCAG TAAATCTGAG

121 CTTGGGGTTT TCAAGGTGAC ACCCGATCAA CGGAAACCCC CAAACTGGCA GCCATGCACA

181 CCCTCTTTAT GCGAGAGCAC AACCGGCTGG CCACCGAGCT GAGACGCCTG AATCCCCGGT

241 GGAATGGAGA CAAACTGTAC AATGAGGCTC GGAAGATCAT GGGGGCCATG GTCCAGGTAA

301 GGAGCTCTGC ATCCCAGCAT CCCCC

( 2 ) INFORMATION FOR SEQ ID NO : 2487 : ( l ) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 421 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2487:

1 CTTTGTATCT CCACCCACCA ATAGTAAATT AATGTTGTCA CATTTGACGT GATGACAATA

61 AAGAATATGT CTGAGCCACC CTTTGAAAAG GCAAGGGTAT GGGTGAGTAG CCTCTGGGGA

121 ATGTTCCTCC TGTCTTCCCT TCCAGATCAT CACCTACCGA GACTTTCTGC CCCTGGTTCT

181 GGGCAAGGCC CGGGCCAGGA GAACCCTGGG GCACTACAGG GGGTACTGCT CCAATGTGGA

241 CCCACGGGTG GCCAATGTCT TCACCCTGGC CTTCCGCTTT GGCCACACAA TGCTCCAGCC

301 CTTCATGTTC CGCTTGGACA GTCAGTACCG GGCCTCCGCA CCCAACTCGC ATGTCCCACT

361 TAGCTCTGCC TTCTTTGCCA GCTGGCGGAT CGTGTATGAA GGTGACCAGG TTTTCCAGGG

421 GGCAAATGGG GGTGAGGGTG GGGAGCATGC CCTCCCCTAG GTGG

(2) INFORMATION FOR SEQ ID NO: 2488: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 361 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xι ) SEQUENCE DESCRIPTION : SEQ ID NO : 2488 :

1 TCCAGCTGCT TCATGTCTCT CCAGAACTCT GTTTCCTGAC AAACGTTACT AACATACCCG 61 ACTGGCTTGT CCAGCTCTGG GCTAGCTTGG CATCATGTGA TAACCCAAGT AGCTTCCCAG 121 AGGCTGGTCC AATCTGTGCT GCTCACATTC CCTGCCACCA GGGGGCATCG ACCCCATCCT 181 CCGGGGCCTC ATGGCCACCC CTGCCAAGCT GAACCGTCAG GATGCCATGT TAGTGGATGA 241 GCTCCGGGAC CGGCTGTTTC GGCAAGTGAG GAGGATTGGG CTGGACCTGG CAGCTCTCAA 301 CATGCAACGA AGCCGGGACC ACGGCCTTCC AGGTGAGGGG GCTGTCCACC TCTTCTCCCA 361 GCTTTGCTCG GGCCAGGCTG CTCAAGGGGT TCTGGGAAGA CCCTGGTACC

(2 ) INFORMATION FOR SEQ ID NO : 2489 : ( l ) SEQUENCE CHARACTERISTICS :

(A) LENGTH : 421 base pairs

(B) TYPE : nucleic acid

( C) STRANDEDNESS : single

( D) TOPOLOGY : linear

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 2489 :

1 CGACTGCCTG GTAGGTTCTG GTGGCAGAAA CGAGGTGTTT TCACCAAAAG ACAGCGCAAG 61 GCCCTGAGCA GAATTTCCTT GTCTCGAATT ATATGTGACA ATACCGGTAT CACCACGGTT 121 TCAAGGGACA TCTTCAGAGC CAACATCTAC CCTCGGGGCT TTGTGAACTG CAGCCGTATC 181 CCCAGGTTGA ACCTATCAGC CTGGCGAGGG ACATGAGGCT TCTGCAGGTA AGGGGAGGCC 241 ACCTCCAGCA CCCTGGGCTG GTTAAGCCTC ACATCCTTCC CTGGATGGAT GGCTGAGTCC 301 TCTTAGGTCT CTAAGCAGAG AAAACAGAAC TTGTCACTAG GTACTCTTTC CAAGTGGCTT

361 CCCAATGTGC TAGTTTCTGG GCTGACAGTC AATTCCAGGC CCTAGGACTT TGGGGGGAAA 421 TTAGGAGCAT CCAACTA

( 2 ) INFORMATION FOR SEQ ID NO : 2490 : ( l ) SEQUENCE CHARACTERISTICS :

(A) LENGTH : 2521 base pairs

(B) TYPE : nucleic acid

(C) STRANDEDNESS : single

(D) TOPOLOGY : linear

(xι)SEQUENCE DESCRIPTION: SEQ ID NO:2490:

1 GAATTCCGTG GCCAGGACCC CTGCCAGGGC ACTGACCCAG CCTCCCCTGG GGCAGTGGAG 61 ACCTCGGTCC TGCGAGACTG CATAGCAGAG GCCAAGTTGC TGGTGGATGC TGCCTACAAT 121 TGGACCCAGA AGAGCATCAA GCAGCGGCTT CGCAGCGGTT CAGCCAGCCC CATGGACCTC 181 CTGTCCTACT TCAAACAACC GGTAGCAGCC ACCAGGACAG TTGTTCGGGC CGCAGATTAT 241 ATGCATGTGG CTTTGGGGCT GCTTGAAGAG AAGTTACAAC CCCAGCGGTC CGGACCCTTC 301 ATTGTCACTG ATGTGCTAAC AGAACCACAG CTGCGGCTGC TGTCCCAGGC CAGTGGCTGT 361 GCTCTCCGGG ACCAGGCCGA GCGCTGCAGC GACAAGTACC GCACCATCAC TGGACGGTGC 421 AACAACAAGA GGAGACCCTT GCTAGGGGCC TCCAACCAGG CTCTGGCTCG CTGGCTGCCC

481 GCCGAGTATG AGGATGGGCT GTCGCTCCCC TTCGGCTGGA CCCCCAGCAG GAGGCGCAAT 541 GGCTTCCTTC TCCCTCTTGT CCGGGCTGTC TCCAACCAGA TTGTGCGCTT CCCCAATGAG EPI-109 648

601 AGACTGACCT CCGACCGTGG CCGAGCCCTC ATGTTCATGC AGTGGGGCCA GTTCATTGAC

661 CATGACCTGG ACTTCTCCCC GGAGTCCCCG GCCAGAGTGG CCTTCACTGC AGGCGTTGAC

721 TGTGAGAGGA CCTGCGCCCA GCTGCCCCCC TGCTTTCCCA TCAAGATCCC ACCCAATGAC 781 CCCCGCATCA AGAACCAGCG TGACTGCATC CCTTTCTTCC GCTCGGCACC CTCATGCCCC 841 CAAAACAAGA ACAGAGTCCG CAACCAGATC AACGCGCTCA CCTCCTTTGT GGACGCCAGC 901 ATGGTGTATG GCAGTGAGGT CTCCCTCTCG CTGCGGCTCC GCAACCGGAC CAACTACCTG 961 GGGCTGCTGG CCATCAACCA GCGCTTTCAA GACAACGGCC GGGCCCTGCT GCCCTTCGAC

1021 AACCTGCACG ATGACCCCTG TCTCCTCACC AACCGCTCGG CGCGCATCCC CTGCTTCCTG 1081 GCAGGTGACA CCCGATCAAC GGAAACCCCC AAACTGGCAG CCATGCACAC CCTCTTTATG 1141 CGAGAGCACA ACCGGCTGGC CACCGAGCTG AGACGCCTGA ATCCCCGGTG GAATGGAGAC 1201 AAACTGTACA ATGAGGCTCG GAAGATCATG GGGGCCATGG TCCAGATCAT CACCTACCGA 1261 GACTTTCTGC CCCTGGTTCT GGGCAAGGCC CGGGCCAGGA GAACCCTGGG GCACTACAGG 1321 GGGTACTGCT CCAATGTGGA CCCACGGGTG GCCAATGTCT TCACCCTGGC CTTCCGCTTT 1381 GGCCACACAA TGCTCCAGCC CTTCATGTTC CGCTTGGACA GTCAGTACCG GGCCTCCGCA 1441 CCCAACTCGC ATGTCCCACT TAGCTCTGCC TTCTTTGCCA GCTGGCGGAT CGTGTATGAA 1501 GGGGGCATCG ACCCCATCCT CCGGGGCCTC ATGGCCACCC CTGCCAAGCT GAACCGTCAG 1561 GATGCCATGT TAGTGGATGA GCTCCGGGAC CGGCTGTTTC GGCAAGTGAG GAGGATTGGG 1621 CTGGACCTGG CAGCTCTCAA CATGCAACGA AGCCGGGACC ACGGCCTTCC AGGGTACAAT 1681 GCTTGGAGGC GCTTCTGTGG GCTCTCCCAG CCCCGGAATT TGGCACAGCT TAGCCGGGTG

1741 CTGAAAAACC AGGACTTGGC AAGGAAGTTC CTGAATTTGT ATGGAACACC TGACAACATT 1801 GACATCTGGA TTGGGGCCAT CGCTGAGCCT CTTTTGCCGG GGGCTCGAGT GGGGCCTCTT

1861 CTGGCTTGTC TGTTCGAGAA CCAGTTCAGA AGAGCCGAGA CGGAGACAGG TTCTGGTGGC 1921 AGAACGAGGT GTTTTCACCA AAGACAGCGC AAGGCCCTGA GCAGAATTTC CTTGTCTCGA 1981 ATTATATGTG ACAATACCGG TATCACCACG GTTTCAAGGG ACATCTTCAG AGCCAACATC 2041 TACCCTCGGG GCTTTGTGAA CTGCAGCCGT ATCCCCAGGT TGAACCTATC AGCCTGGCGA 2101 GGGACATGAG GCTTCTGCAG GAGTCTATCC CAAGTCTCCA ACTTTTGGAG ACAAGGGGAA 2161 GGGGAGGACC ATGAGGCTGC CTTGTCTCCC TGGAGCAAGT GCAGGCTCGT GACGCTTCTG 2221 CTGGCTACAG CTCAGAGCTG GGTTCCCCAG CCAGGAGTGA AGGCTGGGGG CTCCTATCAG 2281 CAATGGACCT TCCGCCTTGG GAGCCTCTTA GGTATTAGGC TATGAATCAG CGCCACGTGC 2341 AAAGGCTTGG GAGCCAAGCC ATGTGGTCTT GCACCCCAGG CAAGAAAAGT CAGCTGGAGG 2401 GTTTACAGCA CTTTCTACTG TTTCCCAGCC CTCCCTCCCC TCCCTCACCA TGACTAAGAG 2461 ACCACTCGGT CCTAGCCTCC AGACACCCCA CAATACTCCT CTGAGCCTGA GGCCAGGCAG 2521 CATGCTCTGC TTCTACCAAT AAAGCACTGC CGGAATTC

(2) INFORMATION FOR SEQ ID NO: 2491: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2581 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2491:

(2) INFORMATION FOR SEQ ID NO:2492: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 781 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xι)SEQUENCE DESCRIPTION: SEQ ID NO:2431:

1 GCATTTTTTC AAGTTTTATG ATTTATTTAA CTTGTGGAAC AAAAATAAAC CAGAAACCAC 61 CACCTCTCAC GCCAAAGCTC ACACCTTCAG CCTCCAACAT GAAGGTCTCC GCAGCACTTC 121 TGTGGCTGCT GCTCATAGCA GCTGCCTTCA GCCCCCAGGG GCTCGCTGGG CCAGCTTCTG 181 TCCCAACCAC CTGCTGCTTT AACCTGGCCA ATAGGAAGAT ACCCCTTCAG CGACTAGAGA 241 GCTACAGGAG AATCACCAGT GGCAAATGTC CCCAGAAAGC TGTGATCTTC AAGACCAAAC 301 TGGCCAAGGA TATCTGTGCC GACCCCAAGA AGAAGTGGGT GCAGGATTCC ATGAAGTATC 361 TGGACCAAAA ATCTCCAACT CCAAAGCCAT AAATAATCAC CATTTTTGAA ACCAAACCAG 421 AGCCTGAGTG TTGCCTAATT TGTTTTCCCT TCTTACAATG CATTCTGAGG TAACCTCATT 481 ATCAGTCCAA AGGGCATGGG TTTTATTATA TATATATATA TTTTTTTTTT AAAAAAAAAC 541 GTATTGCATT TAATTTATTG AGGCTTTAAA ACTTATCCTC CATGAATATC AGTTATTTTT 601 AAACTGTAAA GCTTTGTGCA GATTCTTTAC CCCCTGGGAG CCCCAATTCG ATCCCCTGTC 661 ACGTGTGGGC AATGTTCCCC CTCTCCTCTC TTCCTCCCTG GAATCTTGTA AAGGTCCTGG 721 CAAAGATGAT CAGTATGAAA ATGTCATTGT TCTTGTGAAC CCAAAGTGTG ACTCATTAAA 781 TGGAAGTAAA TGTTGTTTTA GGAATAC

(2) INFORMATION FOR SEQ ID NO: 2492: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 241 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single EPI-109 649

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2492:

1 ATGAAGGTCT CCGCAGC.-.CT TCTGTGGCTG CTGCTCATAG CAGCTGCCTT CAGCCCCCAG

61 GGGCTCGCTG GGCCAGCTTC TGTCCCAACC ACCTGCTGCT TTAACCTGGC CAATAGGAAG

121 ATACCCCTTC AGCGACTAGA GAGCTACAGG AGAATCACCA GTGGCAAATG TCCCCAGAAA

181 GCTGTGATCT TCAAGACCAA ACTGGCCAAG GATATCTGTG CCGACCCCAA GAAGAAGTGG

241 GTGCAGGATT CCATGAAGTA TCTGGACCAA AAATCTCCAA CTCCAAAGCC ATAA

(2) INFORMATION FOR SEQ ID NO:2493: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: base pairs

(B) TYPE: 2641 nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2493:

1 CCACATATTC CCCTCCTTTT CCAAGGCAAG ATCCAGATGG ATTAAAAAAT GTACCAAGTC

61 CCTCCTACTA GCTTGCCTCT CTTCTGTTCT GCTTGACTTC CTAGGATCTG GAATCTGGTC

121 AGCAATCAGG AATCCCTTCA TCGTGACCCC CGCATGGGCA AAGGCTTCCC TGGAATCTCC

181 CACACTGTCT GCTCCCTATA AAAGGCAGGC AGATGGGCCA GAGGAGCAGA GAGGCTGAGA

241 CCAACCCAGA AACCACCACC TCTCACGCCA AAGCTCACAC CTTCAGCCTC CAACATGAAG

301 GTCTCCGCAG CACTTCTGTG GCTGCTGCTC ATAGCAGCTG CCTTCAGCCC CCAGGGGCTC

361 GCTGGGCCAG GTAAGCCCCC CAACTCCTTA CAGGAAAGGT AAGGTAACCA CCTCCAGGCT

421 ACTAGGTCAG CAAGAATCTT TACAGACTCA CTGCAAATTC TCCATTTGAA AAATAGGGAA

481 ACAGGTTTTG TGGGTGGACA AGAAATGCCT CAACCGTCAC ATCCAGTCAC TGGAAGAGCC

541 AGAACTAGAA AGCTCCCGAG TCTTTTCCCC ACATTCAAGA GGGCCGCTGG GTGCATCCTT

601 ACCCAGCTAT CCTTACAGTG TTTGGGAATG GGGAATGGCT CTGTCTTACT GTGGGCATGG

661 TGGGCATTTT TGGCAGTGGG AGAGAAGGAA AATCTGTTGA TTAGAAGCTC AGTATGTTAA

721 TTCGACTCCA GGACAGCTTT CAGAGACAGT GGCTAAGAGA AGAACGAGGT CCCAGGGGAT

781 CTCTTGAGGT GACTTATTTT GACACTCTTT GGGAAAGTTA TCTAGGAGAT TTGTTCCATA

841 ACTCATTTTC CCATACTCTG GTGACAAATT TACTGAGTGT ATCGGTCCCA CTGAGCCAGT

901 GCATAGCATG GTAACAAACA GTTCTAAATT ATCAATGACT TAACAGAATT AACTAAATTA

961 ACAAAAGTTA CTTTCTCACT TGTACTAAAT ATCTATAATG TATGGGCTCA GGCTTCTGCA

1021 TTTTATACTC AGGATTCTAG ACTGATGGAG AAGTTGCCAT GTGGGGGAAC ATTGATGGAT

1081 ACTGTGATAA AGCAGAAGAA AGCTCTCAGG AGTCTTGCAT AGGCAATGCA CTGTGGCTCA

1141 AAAATGACAC CCATCACTTT GTCTCCTTCT TTATTGATCA AAACTAATTA ATGCCTCCAA

1201 CCAAACAAAA GTGGCCAAGA AATGCAAGTC TACCTTGTGT CTCAAAACAG AGGATGGAGA

1261 ATATTTGGTG AAAATTACCA TGACCATCAC ATGGCCACGT AGGTCTTTAT AATGACAGAG

1321 CTAGCATTTG TCACATTGAC CAAGCTTTGT CCATACACTC TACAGTAATG ATGAGTCCTC

1381 AGTGCACAGG GGAGGATGCT GAAGACACAG GACAGCATCC TCCAGACACA TAAGACTTCA

1441 GAGCAGAGGG ATTCTCCCTC CACCTCTCGC AATTCCTTGC TTTCTCCTAA CTTCCTTTAC

1501 AAAGTCATGC TTGGAAATGT CTATGTATCA TCATGTGGCT CATTTTTTTC TCTGTTCATT

1561 TTTTTTCCCC AAAATTCAGC TTCTGTCCCA ACCACCTGCT GCTTTAACCT GGCCAATAGG

1621 AAGATACCCC TTCAGCGACT AGAGAGCTAC AGGAGAATCA CCAGTGGCAA ATGTCCCCAG

1681 AAAGCTGTGA TGTAAGTAAA TAAAGTTCAC CCTCCCCTAG ACAAAAAAAT AATGTCTAGG

1741 GCACAGAGTC AAGAACTGTG GGAGTCATAG ACTCTGATAG TTTGACCTCT ATGGTCCAAT

1801 TCATTAATTT TCACAAGTGA GTGTTCACTC CCAGCTCCCT GCCTGGGAGA TTGCTGTAGT

1861 CATATCAATT TCTTCAAGTC AAGAGCAAAG ATGGTTTTAC TGGGCCTTTA AGAGCAGCAA

1921 CTAACCCAAG AGTCTCATCC TTCCTCCTCT CCGTAGCAAC CCTTTGTCCA GGGGCAGATG

1981 GTCCTTAAAT ATTTAGGGTC AAATGGGCAG AATTTTCAAA AACAATCCTT CCAATTGCAT

2041 CCTGATTCTC CCCACAGCTT CAAGACCAAA CTGGCCAAGG ATATCTGTGC CGACCCCAAG

2101 AAGAAGTGGG TGCAGGATTC CATGAAGTAT CTGGACCAAA AATCTCCAAC TCCAAAGCCA

2161 TAAATAATCA CCATTTTTGA AACCAAACCA GAGCCTGAGT GTTGCCTAAT TTGTTTTCCC

2221 TTCTTACAAT GCATTCTGAG GTAACCTCAT TATCAGTCCA AAGGGCATGG GTTTTATTAT

2281 ATATATATAT ATATATTTTT TTTTAAAAAA AAACGTATTG CATTTAATTT ATTGAGGCTT

2341 TAAAACTTAT CCTCCATGAA TATCAGTTAT TTTTAAACTG TAAAGCTTTG TGCAGATTCT

2401 TTACCCCCTG GGAGCCCCAA TTCGATCCCC TGTCACGTGT GGGCAATGTT CCCCCTCTCC

2461 TCTCTTCCTC CCTGGAATCT TGTAAAGGTC CTGGCAAAGA TGATCAGTAT GAAAATGTCA

2521 TTGTTCTTGT GAACCCAAAG TGTGACTCAT TAAATGGAAG TAATGTTGTT TTAGGAATAC

2581 ATAAAGTATG TGCATATTTT ATTATAGTCA CTAGTTGTAA TTTTTTTGTG GGAAATCCAC

2641 ACTGAGCTGA GGGGG

(2) INFORMATION FOR SEQ ID NO: 2494: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3663 base pairs

(B) TYPE: 2641 nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2494: 1 GCATTTTTTC AAGTTTTATG ATTTATTTAA CTTGTGGAAC AAAAATAAAC CAGAAACCAC EPI-109 650

61 CACCTCTCAC GCCAAAGCTC ACACCTTCAG CCTCCAACAT GAAGGTCTCC GCAGCACTTC 121 TGTGGCTGCT GCTCATAGCA GCTGCCTTCA GCCCCCAGGG GCTCGCTGGG CCAGCTTCTG 181 TCCCAACCAC CTGCTGCTTT AACCTGGCCA ATAGGAAGAT ACCCCTTCAG CGACTAGAGA 241 GCTACAGGAG AATCACCAGT GGCAAATGTC CCCAGAAAGC TGTGATCTTC AAGACCAAAC 301 TGGCCAAGGA TATCTGTGCC GACCCCAAGA AGAAGTGGGT GCAGGATTCC ATGAAGTATC 361 TGGACCAAAA ATCTCCAACT CCAAAGCCAT AAATAATCAC CATTTTTGAA ACCAAACCAG 421 AGCCTGAGTG TTGCCTAATT TGTTTTCCCT TCTTACAATG CATTCTGAGG TAACCTCATT 481 ATCAGTCCAA AGGGCATGGG TTTTATTATA TATATATATA TTTTTTTTTT AAAAAAAAAC 541 GTATTGCATT TAATTTATTG AGGCTTTAAA ACTTATCCTC CATGAATATC AGTTATTTTT 601 AAACTGTAAA GCTTTGTGCA GATTCTTTAC CCCCTGGGAG CCCCAATTCG ATCCCCTGTC 661 ACGTGTGGGC AATGTTCCCC CTCTCCTCTC TTCCTCCCTG GAATCTTGTA AAGGTCCTGG 721 CAAAGATGAT CAGTATGAAA ATGTCATTGT TCTTGTGAAC CCAAAGTGTG ACTCATTAAA 781 TGGAAGTAAA TGTTGTTTTA GGAATACATG AAGGTCT CCGCAGCACT TCTGTGGCTG

801 CTGCTCATAG CAGCTGCCTT CAGCCCCCAG GGGCTCGCTG GGCCAGCTTC TGTCCCAACC 861 ACCTGCTGCT TTAACCTGGC CAATAGGAAG ATACCCCTTC AGCGACTAGA GAGCTACAGG 921 AGAATCACCA GTGGCAAATG TCCCCAGAAA GCTGTGATCT TCAAGACCAA ACTGGCCAAG 981 GATATCTGTG CCGACCCCAA GAAGAAGTGG GTGCAGGATT CCATGAAGTA TCTGGACCAA 1005 AAATCTCCAA CTCCAAAGCC ATAA

1065 CCACATATTC CCCTCCTTTT CCAAGGCAAG ATCCAGATGG ATTAAAAAAT GTACCAAGTC 1121 CCTCCTACTA GCTTGCCTCT CTTCTGTTCT GCTTGACTTC CTAGGATCTG GAATCTGGTC 1181 AGCAATCAGG AATCCCTTCA TCGTGACCCC CGCATGGGCA AAGGCTTCCC TGGAATCTCC 1241 CACACTGTCT GCTCCCTATA AAAGGCAGGC AGATGGGCCA GAGGAGCAGA GAGGCTGAGA 1301 CCAACCCAGA AACCACCACC TCTCACGCCA AAGCTCACAC CTTCAGCCTC CAACATGAAG 1361 GTCTCCGCAG CACTTCTGTG GCTGCTGCTC ATAGCAGCTG CCTTCAGCCC CCAGGGGCTC 1421 GCTGGGCCAG GTAAGCCCCC CAACTCCTTA CAGGAAAGGT AAGGTAACCA CCTCCAGGCT 1481 ACTAGGTCAG CAAGAATCTT TACAGACTCA CTGCAAATTC TCCATTTGAA AAATAGGGAA 1541 ACAGGTTTTG TGGGTGGACA AGAAATGCCT CAACCGTCAC ATCCAGTCAC TGGAAGAGCC 1601 AGAACTAGAA AGCTCCCGAG TCTTTTCCCC ACATTCAAGA GGGCCGCTGG GTGCATCCTT 1661 ACCCAGCTAT CCTTACAGTG TTTGGGAATG GGGAATGGCT CTGTCTTACT GTGGGCATGG 1721 TGGGCATTTT TGGCAGTGGG AGAGAAGGAA AATCTGTTGA TTAGAAGCTC AGTATGTTAA 1781 TTCGACTCCA GGACAGCTTT CAGAGACAGT GGCTAAGAGA AGAACGAGGT CCCAGGGGAT 1841 CTCTTGAGGT GACTTATTTT GACACTCTTT GGGAAAGTTA TCTAGGAGAT TTGTTCCATA 1901 ACTCATTTTC CCATACTCTG GTGACAAATT TACTGAGTGT ATCGGTCCCA CTGAGCCAGT 1961 GCATAGCATG GTAACAAACA GTTCTAAATT ATCAATGACT TAACAGAATT AACTAAATTA 2021 ACAAAAGTTA CTTTCTCACT TGTACTAAAT ATCTATAATG TATGGGCTCA GGCTTCTGCA 2081 TTTTATACTC AGGATTCTAG ACTGATGGAG AAGTTGCCAT GTGGGGGAAC ATTGATGGAT 2141 ACTGTGATAA AGCAGAAGAA AGCTCTCAGG AGTCTTGCAT AGGCAATGCA CTGTGGCTCA 2201 AAAATGACAC CCATCACTTT GTCTCCTTCT TTATTGATCA AAACTAATTA ATGCCTCCAA 2261 CCAAACAAAA GTGGCCAAGA AATGCAAGTC TACCTTGTGT CTCAAAACAG AGGATGGAGA 2321 ATATTTGGTG AAAATTACCA TGACCATCAC ATGGCCACGT AGGTCTTTAT AATGACAGAG 2381 CTAGCATTTG TCACATTGAC CAAGCTTTGT CCATACACTC TACAGTAATG ATGAGTCCTC 2441 AGTGCACAGG GGAGGATGCT GAAGACACAG GACAGCATCC TCCAGACACA TAAGACTTCA 2501 GAGCAGAGGG ATTCTCCCTC CACCTCTCGC AATTCCTTGC TTTCTCCTAA CTTCCTTTAC 2561 AAAGTCATGC TTGGAAATGT CTATGTATCA TCATGTGGCT CATTTTTTTC TCTGTTCATT 2621 TTTTTTCCCC AAAATTCAGC TTCTGTCCCA ACCACCTGCT GCTTTAACCT GGCCAATAGG 2681 AAGATACCCC TTCAGCGACT AGAGAGCTAC AGGAGAATCA CCAGTGGCAA ATGTCCCCAG 2741 AAAGCTGTGA TGTAAGTAAA TAAAGTTCAC CCTCCCCTAG ACAAAAAAAT AATGTCTAGG 2801 GCACAGAGTC AAGAACTGTG GGAGTCATAG ACTCTGATAG TTTGACCTCT ATGGTCCAAT 2861 TCATTAATTT TCACAAGTGA GTGTTCACTC CCAGCTCCCT GCCTGGGAGA TTGCTGTAGT 2921 CATATCAATT TCTTCAAGTC AAGAGCAAAG ATGGTTTTAC TGGGCCTTTA AGAGCAGCAA 2981 CTAACCCAAG AGTCTCATCC TTCCTCCTCT CCGTAGCAAC CCTTTGTCCA GGGGCAGATG 3041 GTCCTTAAAT ATTTAGGGTC AAATGGGCAG AATTTTCAAA AACAATCCTT CCAATTGCAT 3101 CCTGATTCTC CCCACAGCTT CAAGACCAAA CTGGCCAAGG ATATCTGTGC CGACCCCAAG 3161 AAGAAGTGGG TGCAGGATTC CATGAAGTAT CTGGACCAAA AATCTCCAAC TCCAAAGCCA 3221 TAAATAATCA CCATTTTTGA AACCAAACCA GAGCCTGAGT GTTGCCTAAT TTGTTTTCCC 3281 TTCTTACAAT GCATTCTGAG GTAACCTCAT TATCAGTCCA AAGGGCATGG GTTTTATTAT 3341 ATATATATAT ATATATTTTT TTTTAAAAAA AAACGTATTG CATTTAATTT ATTGAGGCTT 2341 TAAAACTTAT CCTCCATGAA TATCAGTTAT TTTTAAACTG TAAAGCTTTG TGCAGATTCT 2401 TTACCCCCTG GGAGCCCCAA TTCGATCCCC TGTCACGTGT GGGCAATGTT CCCCCTCTCC 2461 TCTCTTCCTC CCTGGAATCT TGTAAAGGTC CTGGCAAAGA TGATCAGTAT GAAAATGTCA 2521 TTGTTCTTGT GAACCCAAAG TGTGACTCAT TAAATGGAAG TAATGTTGTT TTAGGAATAC 2581 ATAAAGTATG TGCATATTTT ATTATAGTCA CTAGTTGTAA TTTTTTTGTG GGAAATCCAC 2641 ACTGAGCTGA GGGGG

( 2 ) INFORMATION FOR SEQ ID NO : 2495 : ( l ) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 61 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single EPI-109 651

( D) TOPOLOGY , linear ( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 2495 :

1 GCCAGGTCGC TGTTGGTCCA CGCCGCCCGT CGCGCCGCCC GCCCGCTCAG CGTCCGCCGC 61 CGCCATGGGA

( 2 ) INFORMATION FOR SEQ ID NO : 2496 : ( i ) SEQUENCE CHARACTERISTICS :

(A) LENGTH : 841 base pairs

( B ) TYPE : nucleic acid

( C ) STRANDEDNESS : single

( D ) TOPOLOGY : linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2496:

1 GGCCGGAGCC GAGCCGGGGT CGGGCAGCAG CAGGGACCCC CCAGAGGCGG GGCCTGTGGG

61 ACCGCTATGG GCGTGGAGAT CGAGACCATC TCCCCCGGAG ACGGAAGGAC ATTCCCCAAG

121 AAGGGCCAAA CGTGTGTGGT GCACTACACA GGAATGCTCC AAAATGGGAA GAAGTTTGAT

181 TCATCCAGAG ACAGAAACAA ACCTTTCAAG TTCAGAATTG GCAAACAGGA AGTCATCAAA

241 GGTTTTGAAG AGGGTGCAGC CCAGATGAGC TTGGGGCAGA GGGCGAAGCT GACCTGCACC

301 CCTGATGTGG CATATGGAGC CACGGGCCAC CCCGGTGTCA TCCCTCCCAA TGCCACCCTC

361 ATCTTTGACG TGGAGCTGCT CAACTTAGAG TGAAGGCAGG AAGGAACTCA AGGTGGCTGG

421 AGATGGCTGC TGCTCACCCT CCTAGCCTGC TCTGCCACTG GGACGGCTCC TGCTTTTGGG

481 GCTCTTGATC AGTGTGCTAA CCTCACTGCC TCATGGCATC ATCCATTCTC TCTGCCCAAG

541 TTGCTCTGTA TGTGTTCGTC AGTGTTCATG CGAATTCTTG CTTGAGGAAA CTTCGGTTGC

601 AGATTGAAGC ATTTCAGGTT GTGCATTTTG TGTGATGCAT GTAGTAGCCT TTCCTGATGA

661 CAGAACACAG ATCTCTTGTT CGCACAATCT ACACTGCCTT ACCTTCACTT AAACCACACA

721 CACAAGGTGC TCAGACATGA AATGTACATG GCGTACCGTA CACAGAGGGA CTTGAGCCAG

781 TTACCTTTGC TGTCACTTTC TCTCTTATAA ATTCTGTTAG CTGCTCACTT AAACAATGTC

841 CTCTTTGAGA AAATGTAAAA TAAAGGCTCT GTGCTTGACA

(2) INFORMATION FOR SEQ ID NO: 2497: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1501 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2497:

1 GAATTCGGGC CGCCGCCAGG TCGCTGTTGG TCCACGCCGC CCGTCGCGCC GCCCGCCCGC

61 TCAGCGTCCG CCGCCGCCAT GGGAGTGCAG GTGGAAACCA TCTCCCCAGG AGACGGGCGC

121 ACCTTCCCCA AGCGCGGCCA GACCTGCGTG GTGCACTACA CCGGGATGCT TGAAGATGGA

181 AAGAAATTTG ATTCCTCCCG GGACAGAAAC AAGCCCTTTA AGTTTATGCT AGGCAAGCAG

241 GAGGTGATCC GAGGCTGGGA AGAAGGGGTT GCCCAGATGA GTGTGGGTCA GAGAGCCAAA

301 CTGACTATAT CTCCAGATTA TGCCTATGGT GCCACTGGGC ACCCAGGCAT CATCCCACCA

361 CATGCCACTC TCGTCTTCGA TGTGGAGCTT CTAAAACTGG AATGACAGGA ATGGCCTCCT

421 CCCTTAGCTC CCTGTTCTTG GATCTGCCAT GGAGGGATCT GGTGCCTCCA GACATGTGCA

481 CATGAGTCCA TATGGAGCTT TTCCTGATGT TCCACTCCAC TTTGTATAGA CATCTGCCCT

541 GACTGAATGT GTTCTGTCAC TCAGCTTTGC TTCCGACACC TCTGTTTCCT CTTCCCCTTT

601 CTCCTCGTAT GTGTGTTTAC CTAAACTATA TGCCATAAAC CTCAAGTTAT TCATTTTATT

661 TTGTTTTCAT TTTGGGGTGA AGATTCAGTT TCAGTCTTTT GGATATAGGT TTCCAATTAA

721 GTACATGGTC AAGTATTAAC AGCACAAGTG GTAGGTTAAC ATTAGAATAG GAATTGGTGT

781 TGGGGGGGGG GTTTGCAAGA ATATTTTATT TTAATTTTTT GGATGAAATT TTTATCTATT

841 ATATATTAAA CATTCTTGCT GCTGCGCTGC AAAGCCATAG CAGATTTGAG GCGCTGTTGA

901 GGACTGAATT ACTCTCCAAG TTGAGAGATG TCTTTGGGTT AAATTAAAAG CCCTACCTAA

961 AACTGAGGTG GGGATGGGGA GAGCCTTTGC CTCCACCATT CCCACCCACC CTCCCCTTAA

1021 ACCCTCTGCC TTTGAAAGTA GATCATGTTC ACTGCAATGC TGGACACTAC AGGTATCTGT

1081 CCCTGGGCCA GCAGGGACCT CTGAAGCCTT CTTTGTGGCC _TTτTTTTTTT TTCATCCTGT

1141 GGTTTTTCTA ATGGACTTTC AGGAATTTTG TAATCTCATA ACTTTCCAAG CTCCACCACT

1201 TCCTAAATCT TAAGAACTTT AATTGACAGT TTCAATTGAA GGTGCTGTTT GTAGACTTAA

1261 CACCCAGTGA AAGCCCAGCC ATCATGACAA ATCCTTGAAT GTTCTCTTAA GAAAATGATG

1321 CTGGTCATCG CAGCTTCAGC ATCTCCTGTT TTTTGATGCT TGGCTCCCTC TGCTGATCTC

1381 AGTTTCCTGG CTTTTCCTCC CTCAGCCCCT TCTCACCCCT TTGCTGTCCT GTGTAGTGAT

1441 TTGGTGAGAA ATCGTTGCTG CACCCTTCCC CCAGCACCAT TTATGAGTCT CAAGTTTTAT

1501 TATTGCAATA AAAGTGCTTT ATGCCCGAAT TC

(2) INFORMATION FOR SEQ ID NO:2498: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 541 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( xι ) SEQUENCE DESCRIPTION : SEQ ID NO : 24 98 :

1 GCCGCCGCCA TGGGAGTGCA GGTGGAAACC ATCTCCCCAG GAGACGGGCG CACCTTCCCC EPI-109 652

61 AAGCGCGGCC AGACCTGCGT GGTGCACTAC ACCGGGATGC TTGAAGArGG AAAGAAATTT 121 GATTCCTCCC GGGACAGAAA CAAGCCCTTT AAGTTTATGC TAGGCAAGCA GGAGGTGATC 181 CGAGGCTGGG AAGAAGGGGT TGCCCAGATG AGTGTGGGTC AGAGAGCCAA ACTGACTATA 241 TCTCCAGATT ATGCCTATGG TGCCACTGGG CACCCAGGCA TCATCCCACC ACATGCCACT 301 CTCGTCTTCG ATGTGGAGCT TCTAAAACTG GAATGACAGG AATGGCCTCC TCCCTTAGCT

361 CCCTGTTCTT GGATCTGCCR TGGAGGGATC TGGTGCCTCC AGACATGTGC ACATGARTCC

421 ATATGGAGCT TTTCCTGATG TTCCACTCCA CTTTGTATAG ACATCTGCCC TGACTGAATG 481 TGTTCTGTCA CTCAGCTTTG CTTCCGACAC CTCTGTTTCC TCTTCCCCTT TCTCCTCGTA 541 TGTGTGTTTA CCTAAACTAT ATGCCATAAA CCTCAAGTTA TTCA

(2) INFORMATION FOR SEQ ID NO: 2499: (1) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3135 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2499:

1 GCCAGGTCGC TGTTGGTCCA CGCCGCCCGT CGCGCCGCCC GCCCGCTCAG CGTCCGCCGC 61 CGCCATGGGA GGCCGGAGCC GAGCCGGGGT CGGGCAGCAG CAGGGACCCC CCAGAGGCGG 121 GGCCTGTGGG ACCGCTATGG GCGTGGAGAT CGAGACCATC TCCCCCGGAG ACGGAAGGAC 181 ATTCCCCAAG AAGGGCCAAA CGTGTGTGGT GCACTACACA GGAATGCTCC AAAATGGGAA 241 GAAGTTTGAT TCATCCAGAG ACAGAAACAA ACCTTTCAAG TTCAGAATTG GCAAACAGGA 301 AGTCATCAAA GGTTTTGAAG AGGGTGCAGC CCAGATGAGC TTGGGGCAGA GGGCGAAGCT

361 GACCTGCACC CCTGATGTGG CATATGGAGC CACGGGCCAC CCCGGTGTCA TCCCTCCCAA 421 TGCCACCCTC ATCTTTGACG TGGAGCTGCT CAACTTAGAG TGAAGGCAGG AAGGAACTCA

481 AGGTGGCTGG AGATGGCTGC TGCTCACCCT CCTAGCCTGC TCTGCCACTG GGACGGCTCC 541 TGCTTTTGGG GCTCTTGATC AGTGTGCTAA CCTCACTGCC TCATGGCATC ATCCATTCTC 601 TCTGCCCAAG TTGCTCTGTA TGTGTTCGTC AGTGTTCATG CGAATTCTTG CTTGAGGAAA 661 CTTCGGTTGC AGATTGAAGC ATTTCAGGTT GTGCATTTTG TGTGATGCAT GTAGTAGCCT 721 TTCCTGATGA CAGAACACAG ATCTCTTGTT CGCACAATCT ACACTGCCTT ACCTTCACTT 781 AAACCACACA CACAAGGTGC TCAGACATGA AATGTACATG GCGTACCGTA CACAGAGGGA 841 CTTGAGCCAG TTACCTTTGC TGTCACTTTC TCTCTTATAA ATTCTGTTAG CTGCTCACTT 901 AAACAATGTC CTCTTTGAGA AAATGTAAAA TAAAGGCTCT GTGCTTGACA GAATTCGGGC 961 CGCCGCCAGG TCGCTGTTGG TCCACGCCGC CCGTCGCGCC GCCCGCCCGC

1011 TCAGCGTCCG CCGCCGCCAT GGGAGTGCAG GTGGAAACCA TCTCCCCAGG AGACGGGCGC 1171 ACCTTCCCCA AGCGCGGCCA GACCTGCGTG GTGCACTACA CCGGGATGCT TGAAGATGGA 1231 AAGAAATTTG ATTCCTCCCG GGACAGAAAC AAGCCCTTTA AGTTTATGCT AGGCAAGCAG 1291 GAGGTGATCC GAGGCTGGGA AGAAGGGGTT GCCCAGATGA GTGTGGGTCA GAGAGCCAAA 1351 CTGACTATAT CTCCAGATTA TGCCTATGGT GCCACTGGGC ACCCAGGCAT CATCCCACCA 1411 CATGCCACTC TCGTCTTCGA TGTGGAGCTT CTAAAACTGG AATGACAGGA ATGGCCTCCT 1471 CCCTTAGCTC CCTGTTCTTG GATCTGCCAT GGAGGGATCT GGTGCCTCCA GACATGTGCA 1531 CATGAGTCCA TATGGAGCTT TTCCTGATGT TCCACTCCAC TTTGTATAGA CATCTGCCCT 1591 GACTGAATGT GTTCTGTCAC TCAGCTTTGC TTCCGACACC TCTGTTTCCT CTTCCCCTTT 1651 CTCCTCGTAT GTGTGTTTAC CTAAACTATA TGCCATAAAC CTCAAGTTAT TCATTTTATT 1711 TTGTTTTCAT TTTGGGGTGA AGATTCAGTT TCAGTCTTTT GGATATAGGT TTCCAATTAA 1771 GTACATGGTC AAGTATTAAC AGCACAAGTG GTAGGTTAAC ATTAGAATAG GAATTGGTGT 1831 TGGGGGGGGG GTTTGCAAGA ATATTTTATT TTAATTTTTT GGATGAAATT TTTATCTATT 1891 ATATATTAAA CATTCTTGCT GCTGCGCTGC AAAGCCATAG CAGATTTGAG GCGCTGTTGA 1951 GGACTGAATT ACTCTCCAAG TTGAGAGATG TCTTTGGGTT AAATTAAAAG CCCTACCTAA 2011 AACTGAGGTG GGGATGGGGA GAGCCTTTGC CTCCACCATT CCCACCCACC CTCCCCTTAA 2071 ACCCTCTGCC TTTGAAAGTA GATCATGTTC ACTGCAATGC TGGACACTAC AGGTATCTGT 2131 CCCTGGGCCA GCAGGGACCT CTGAAGCCTT CTTTGTGGCC TTTTTTTTTT TTCATCCTGT 2191 GGTTTTTCTA ATGGACTTTC AGGAATTTTG TAATCTCATA ACTTTCCAAG CTCCACCACT 2251 TCCTAAATCT TAAGAACTTT AATTGACAGT TTCAATTGAA GGTGCTGTTT GTAGACTTAA 2331 CACCCAGTGA AAGCCCAGCC ATCATGACAA ATCCTTGAAT GTTCTCTTAA GAAAATGATG 2391 CTGGTCATCG CAGCTTCAGC ATCTCCTGTT TTTTGATGCT TGGCTCCCTC TGCTGATCTC 2451 AGTTTCCTGG CTTTTCCTCC CTCAGCCCCT TCTCACCCCT TTGCTGTCCT GTGTAGTGAT 2511 TTGGTGAGAA ATCGTTGCTG CACCCTTCCC CCAGCACCAT TTATGAGTCT CAAGTTTTAT 2561 TATTGCAATA AAAGTGCTTT ATGCCCGAAT TC

2594 GCCGCCGCCA TGGGAGTGCA GGTGGAAACC ATCTCCCCAG GAGACGGGCG CACCTTCCCC 2655 AAGCGCGGCC AGACCTGCGT GGTGCACTAC ACCGGGATGC TTGAAGATGG AAAGAAATTT 2715 GATTCCTCCC GGGACAGAAA CAAGCCCTTT AAGTTTATGC TAGGCAAGCA GGAGGTGATC 2775 CGAGGCTGGG AAGAAGGGGT TGCCCAGATG AGTGTGGGTC AGAGAGCCAA ACTGACTATA 2835 TCTCCAGATT ATGCCTATGG TGCCACTGGG CACCCAGGCA TCATCCCACC ACATGCCACT 2895 CTCGTCTTCG ATGTGGAGCT TCTAAAACTG GAATGACAGG AATGGCCTCC TCCCTTAGCT 2955 CCCTGTTCTT GGATCTGCCR TGGAGGGATC TGGTGCCTCC AGACATGTGC ACATGARTCC 3015 ATATGGAGCT TTTCCTGATG TTCCACTCCA CTTTGTATAG ACATCTGCCC TGACTGAATG 3075 TGTTCTGTCA CTCAGCTTTG CTTCCGACAC CTCTGTTTCC TCTTCCCCTT TCTCCTCGTA 3135 TGTGTGTTTA CCTAAACTAT ATGCCATAAA CCTCAAGTTA TTCA EPI-109 653

(2) INFORMATION FOR SEQ ID NO: 2500: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 7621 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2500:

1 AACAAGAAAA GCGTTGGTAG CTCTGGTGAA TCCCAAAAGA ATGTGGCAGT TGCTAGCCAT 61 GCTCCTGAAT ATGTATAAAC AGTACATCAT ATGACTAAGA GTTTGACTTA GGGGTTAGAT 121 TTTATGTGTT TGAACCCCAA ATTAGTTATT TAATAGTTGG CACCCCAAAA CAAGTTACTT 181 AACCTCACTA AGGTTCAGTT TTCCTGTTTA TAAAATGTAG ATAGTGATAG TATGTACTTT 241 ATAGGATTAT TGTGAAAAAT AAATGAAATA TCAGATTTAT TTAGGATAAC ACCTGGCATA 301 TGTTTGGTAT TCAGAATTAG TTGCTGCTGT TTTATTCTGC TCTCCCTTGC ATCCCACTTT 361 TCTAAGTTGT AAACTAAATA GTTGTACACA GATTGACAGA TTAAGAAAGG CTTGTGATTG 421 TGCTAGACCT ATGCCTATGC CTCTGTCTCA CCAGATTCCA GGTGTATATG TGGAGGTGGG 481 ATAGGGAGTG GAGTAAGTGG GTAAATATTA AATTGCCCAG TTGGGCACCA TCCTGAATAT 541 TATCTCTAAA GAAAGAAGCA AAACCAGGCA CAGCTGATGG GTTAACCAGA TATGATACAG 601 AAAACATTTC CTTCTGCTTT TTGGTTTTAA GCCTATATTT GAAGCCTTAG ATCTCTCCAG 661 CACAGTAAGC ACCAGGAGTC CATGAAGAAG ATG

(2) INFORMATION FOR SEQ ID NO:2501: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 7621 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2501:

1 GATCTTCATG TGGAATGACT GGTTTCATTC AATAGACTTA ATTCAGCAGT CTGTGGGGAA

61 GAGCAAGGTA TGATAGAATG GTTCCTCAAG TGCTTCAGAT GTGAAGTGGG TTTAAATATA

121 CTGTCCCTGT CTTCTTCAGA GTTTTGGTAA AGATAAAATA GGACACTCAT TTAAAAGCAA

181 TCTTTGCAAA TGACAAGCCA CTATAGACAT TAATAGAGTT TTCATTTCCA GTATTATCAT

241 TAATATCAGA TCCTGGAAGA AGGTTGAGCC TTGACCTAGA GCAAAAAAAC AGAAGAATTA

301 GTAAAGGAAT CCTGGAGAAA GCCCCTGCTG TGTATTTAAA GGAGAAAGGG AGATCATGTT

361 GGGAAATTAT AATATTAAAA GTAAACAAAA GCTAGGAAGT AAAATAAAAT AAATTATATG

421 GCCTAGATCC CCATAAGTAA TGGTTTAACT TCTGCCTTCC TGTGTTCTGA GCCAGATTAG

481 GGCACAGTAG AGAAAGAGGA GTCTCTGAAA ATGTTTCCAA TTTCGCTGGT CAGACAGCGG

541 ATCATCAGTG AATCAGATGA AAATTTGTGG ATTTATGCAC TAACTGATCA GCAGGAAATT

601 AAACAAGAAA AGCGTTGGTA GCTCTGGTGA ATCCCAAAAG AATTTGGCAG TTGCTAGCCA

661 TGCTCCTGAA TATGTATAAA CAGTACATCA TATGACTAAG AGTTTGACTT AGGGGTTAGA

721 TTTTATGTGT TTGAACCCCA AATTAGTTAT TTAATAGTTG GCACCCCAAA ACAAGTTACT

781 TAACCTCACT AAGATTCAGT TTTCCTGTTT ATAAAATGTA GATAGTGATA GTATGTACTT

841 TATAGGATTA TTGTGAAAAA TAAATGAAAT ATCAGATTTA TTTAGGATAA CACCTGGCAT

901 ATGTTTGGTA TTCAGTAATT AGTTGCTGCT GTTTTATTCT GCTCTCCCTT GCATCCCACT

961 TTTCTAAGTT GTAAACTAAA TAGTTGTACA CAGATTGACA GATTAAGAAA GGCTTGTGAT

1021 TGTGCTAGAC CTATGCCTCT CTCTCACCAG ATTCCAGGTG TATATGTGGA GGTGGGATAG

1081 GGAGTGGAGT AAGTGGGTAA ATATTAAATT GCCCAGTTGG GCACCATCCT GAATATTATC

1141 TCTAAAGAAA GAAGCAAAAC CAGGCACAGC TGATGGGTTA ACCAGATATG ATACAGAAAA

1201 CATTTCCTTC TGCTTTTTGG TTTTAAGCCT ATATTTGAAG CCTTAGATCT CTCCAGCACA

1261 GTAAGCACCA GGAGTCCATG AAGAAGATGG CTCCTGCCAT GGAATCCCCT ACTCTACTGT

1321 GTGTAGCCTT ACTGTTCTTC GGTAAGTAGA GATTCAATTA CCCCTCCCAG GGAGGCCCAA

1381 ATGAATTTGG GGAGCAGCTG GGGTAGGAAC CTTTACTGTG GGTGGTGACT TTTTCTAGGA

1441 CATGTGCAAA CTATTGGGCA TTTCCCAGGG ACTCTGTAGT GGAGCCAAGC TAGAAAGCAG

1501 AGGCAAGTGG GCTGAGCAAC ACCTAAGGAG GAAGCCAGAC TGAAAGCTTG GTTCCTTGCA

1561 TTTGCTCTGG CATCTTCCAG AGTGCAAATT TCCTACCAAG GTAATGAGGG TAGAGGAGAG

1621 AAAGAAGCTC TTTCTTCCCC TGATTCTCAT TCCTGAAAAG ACGGTTGGTC CTTAAAATTC

1681 CATGGATGTA GATCTTATCC CCACACCCAG ATTCTAGTCC TCTGGAGATA AAGAAGACTG

1741 CTGGACACTA ATGTATCCTC TCTGGACTTT TGCAGCTCCA GATGGCGTGT TAGCAGGTGA

1801 GTCCTCTGTT CTTGTTCCCT TGGTGTATCA ACATGTCTGG GCATTGCTTT CCTCTCACTA

1861 TTTTCTTCGT CCCATCACTT CTGCTTTCTA ATGAGCATGA ATCTGTTCCT TGGCCAGACT

1921 ACTTTCCCTC TCCACCTTGC CTTGTCTTTC TTTTTTTCCC TGATTCATTG CATTCTCTCA

1981 AGTCATTCTC TCCTCTGTTT TAGTCAATAA CCATGTCTGT TGCACATATA CATGTCTCAT

2041 TCTCTCTCCT AGACACTTTG GCATGATCTC GCTCAATAAT TACATTATTA TTATTATTGC

2101 CATTTTATAA TTGAGGATGC TGAAACTCAG TGATTTTCTG GTGGTTACAT GGCTAAGGAA

2161 CTGGATTTCA ACGTAAGTTC CTTGGATCTA AGTCCAGTTC TCTTCTGACT ATATCACCCT

2221 TTTGTTATCA CCATGTATCT ACTTCTTTGG TCTCTGTTCA AATTTGCACT ACATCCCCTT

2281 GTTCCAGGAA GCCATTCAAG ACTGACTTTC TTAGTGCCTC TCACTACTTT CTGGAACTGA

2341 CATATGTTTT TCACTCTGTA TATACTTACA ATTAAATAGT CATAAATATT CAGAGCTTGG

2401 AGAAACCTTA TATTTCATCC AGTCCAGTAA ATTTATCCAT CCATAATTCA CTCATTCATT

2461 CACATAATAA ATATTTAATG TAACAATGGT TGAACATGGC AGACAGTGTT TCTACCTCAA

2521 AAGAGATTGC AGTCCTCATT TACAGATACT GAATTGAAAT TAACAGAAGT AGAGTGAGTC EPI-109 654

2581 AGCTCAAATC ACATAGTGAA TTGGTTTCTT TGTTTTTAAA TCTCCTGCAT ATGTGTCCTG

2641 TCTTTCTCCC TGTGTTGGGC GTTCCCTGGG GCACCAATAC TAATTTCTCC TTCCCCTAGA

2701 AATCAAAACA GGGTCTTATC ACCAACAGAA TAAGGACAGG TTGACCACTG ATTGTCAGAA

2761 TATTGCTTCG TTTGTACTTT TAAGCCTAGA CAGTTTTCAA TGACTTTTTT TCTCTCTACA

2821 TGTCTTTTCA TATTTTTATC TTCTTGAAGT CCCTCAGAAA CCTAAGGTCT CCTTGAACCC

2881 TCCATGGAAT AGAATATTTA AAGGAGAGAA TGTGACTCTT ACATGTAATG GGAACAATTT

2941 CTTTGAAGTC AGTTCCACCA AATGGTTCCA CAATGGCAGC CTTTCAGAAG AGACAAATTC 3001 AAGTTTGAAT ATTGTGAATG CCAAATTTGA AGACAGTGGA GAATACAAAT GTCAGCACCA 3061 ACAAGTTAAT GAGAGTGAAC CTGTGTACCT GGAAGTCTTC AGTGGTAAGT TCCAGGGATA 3121 TGGAAATACA GATCTCTCAT GTGAGGGATG GCTCATCTGA AGATGGGAAA AAACAGGTTA 3181 TTCCAAGGGT TAGGACACCA GAGTGGGATT CAAGGCCTCT CATTTTTAAG ACCCCTGCAT 3241 TGGCTGGGCA CAGTGGCTCA CGCCTGTAAT CCCAGCACTT TGGGAGGCTG AGGCAGGTGG 3301 ATCACGAGGT CAGGAGATCG AGACCATCCG GCTAACATGG TGAAACCCCA TCTCTGCTAA 3361 AAAATATATA TATATAAAAT TAGCCGGGCG TAGTGGTGGG CACCTGTAGT CCCAGGTACT 3421 CGGGAGGCTG AGGCAGGAGA ATGGTGTGAA CCCAGGAGGT GGAGGTTGCA GTGAGCTGAG 3481 ATCACGCCAC TGCCCTCCAG CCTGGGCTAC AGAGCAAGAC TCCGTCTCAA AAAATAAATA 3541 AATAAATAAA AAAGACCCCT GCATCTCTTT TCTTCTACCC CCTTCCCTTT TGATTACTTG 3601 TATGCCTTCT TTCAATATTC TAGTCATCTC TCAATATTAT TCCTCCACCC TATTTTCCTC 3661 TATCTTTTCT GCCTAGATTC AGGTATATAT TATGTGGTCA AACAGCATGA CATATATGTG 3721 AACATTTCAA AGAGCTGTGT ATCTGGAATA GGATCAAAAG GTTTGACTTA AAGTTTTGCT 3781 CTGCATAATC CATATGGCAG GACCTGAATA TTAGGTTGTA CTCTTCGTTA TGAAACATAT 3841 CTGGGTACAT TTCCTTATGT CCTCTGTTGT TACTTAAGAA CACATATTTC ATGCTTGTTT

3901 CATTTTTATC ACTCCTACTG CCAACAAATA GCATAGCATG CTTAGGCACA TGTGGCTTAA

3961 TTAGCAAATG TTGAATAAAC AAATTAATGA TTTTGAATAG TGACCAATAG GTCTCTTTTA

4021 TACTCTATAT TTTTCTCTTG AGTGAAAAAA AATGTTTCAA CCTCCATATG TAAATTCCAA 4081 ACACAAACTA AAGCAATGTA GAATAGCTTC TTTATTCCCT GGAGTAGGTT CTAGAGAAGT 4141 CCTAAAGGAT TGGTCCTAAA TTAATTATGC TTATTATGCT AGCGATATTT CCTTTCAAAA 4201 TTCTCCTTTA ATGAATGCTT TTTAATTTTT ACAAAAGCAT TAACCATAGA ATGTGATTCT 4261 TGTCTTTCAC TGACTCATTA GTGACAAATA TTTGTTGAGT ACCTACCAAC TCCTAAGTAT 4321 TGCTACCAAC TCCTAAATAC TGTGTTGGGC ATTCAGAATA GAATGTAGAA CTAGACAGGG 4381 TCCCTGACTT CTTGGAGCAC AGAGCAGTAT GGGAAGAGGA CATTAAATAA AGAATTACAT 4441 AAGTAATTAA TTTAAATTAT ACATGTTTTG AAGAAGTTTT TTTTTGACAA CTATAATTAA 4501 CACTAGAACT GGGAAGTTTC TATAAGGTAA GAGAGGACAA AATAGACACT CTCCTAAGCT 4561 AAAATTCCCA AGAAAGACTG TTTATTTTCC CCTAACTAAC TAGAACTAGC AACAGAAGAT 4621 CTGAAAGGAA TTCTGGCTTT CAAGTGTTCC ATGTATGGAC TCATCAGGGA GGTCCGAGAG 4681 GCTTTGTGGC CCCAGACTGA CTTTTCAGGA GGGGAAAGGA TTTATCAATA CACAAGACAG 4741 GCTCTAAGCA TTATTTTGTG CCCTTTAAAA ATCCACTTTA TGAGCCAAAA AGTGAGTTAA 4801 TGATAATTCA TAGTTTCTGA CACATGCTCT ATGCGTGGCT CTCTTTTCTC TATTCATTCT 4861 CTCTCTCTTC ATTTATTGTT AAATAAATAA TGTAATGAAT GTTCTTCAGA CTGGCTGCTC 4921 CTTCAGGCCT CTGCTGAGGT GGTGATGGAG GGCCAGCCCC TCTTCCTCAG GTGCCATGGT 4 981 TGGAGGAACT GGGATGTGTA CAAGGTGATC TATTATAAGG ATGGTGAAGC TCTCAAGTAC 5041 TGGTATGAGA ACCACAACAT CTCCATTACA AATGCCACAG TTGAAGACAG TGGAACCTAC 5101 TACTGTACGG GCAAAGTGTG GCAGCTGGAC TATGAGTCTG AGCCCCTCAA CATTACTGTA 5161 ATAAAAGGTG AGTTGGTAAA GGAAAGGAAA AGCATCCATA GCAGGGGAAG GAAGAGAGAA 5221 CTTCTGAGCC TGAGCAGTTG CAGCTTGTAG AAGGGGGGCA CCTGTGATAC ACTGGAAAGC 5281 CTACCAGACT TGCAATGAGG AGACCTGGGT GATAGTATAT ATCTCAATCT CTGTTTCAAA 5341 GCCTTGACTT GTTAAATGGT GATAGTAATA CCTGCTTGCA CTATGAAATT TTTATGAAGA 5401 TTAATGTGGT AATATTTGTG AAATGACTTT GTAAACTGTT AAGCACTACC CAAGCATAAC 5461 AGATTGTGAT TACTATTTTG ATCTCAAAGT CATCTGTTGC TCCTGGGGGA ACACTTATAT 5521 TTATCAAATT GAAAAAAAGT TTCAAAGTTG AATGAAGAAA GGATATAAAG AGCTTGAGGA 5581 GCCCATTCCA GCTTAGGAGG GCTGGGAAAG GAAACCAGCA AGTCAGTAAG CTGTGTGCCT 5641 GTGTATTGAG GGAGGAGGGA ATGGACTTGA TATGGAGAGG GTAGGGAGGT GGACTGCCTC 5701 TATGGCCTGT AAGAAAAACT GCTCTCTCCA AACTCTTTAT AAGAGAGGGA GCCTGTGAAG 5761 TATTCACTTT TGAAGGAGAA AGTTAGACTT TTCCTTCACA CACTTTGTAC ATAATAATGT 5821 TTAAAAAAGC ATGAGGTCAA AATACATAAT TAAGTCCTAG CAGTTCTCTG TTAACTAATT 5881 TGAGACTGAA GTGCTATGTA CTTGTCTCTA GGCTTCCAGT ATCTTCATCT GTAAAACAGA 5941 ATATTTGGTC TAGATTCCAT TAGAATCATT TGATAACTTA AAAAATATAT TGATGCTCAT 6001 GTCTCATTTC TTGAGATTCT GATTTAATTG GTTTGGGGTG CAGCCTGGGT ATACGTATTT 6061 TTCATAGGTC TTTCACATAA TGGTAATGGG TAGCCAATAT TGAGAATCAC TTGTCTAGGT 6121 GATCTTTAAA TGATTTCTGG ATGTAATATT CTGAGGCTCT ATAATTTGAG ACTAATCACA 6181 AAAATCGGTA CAGTTTATAA ACAGACTAAC AGAACCACAA AATAATAGAA TTGGAAGGCA 6241 ATTTAACTAG TGCAATTTCT TCATTTTGCC TAACAGGCAT GTAAGAAATG ATGATTGATT 6301 GAGTAATAGG CATTGATGAC CCCTGTCCTC ACTTTGTCCC CTTTCCACCC CTTAATTATA 6361 TGTGAATTCT GGTCTTGTCA TTTCGAATAA GGGGTTTATC TTTCCTATTG TCTTCCCCTC 6421 TGGGCACGGC ACACTGGCTA CTGGAGTTAA GAGGAAATGC TTAGGACTCC CTGTGGCTCC 6481 AGGGAGCACC AACAGAGCAA CTCAACCTAG TGTTAATCTG AGTGTTTTCT CTGTGCTTCT 6541 GGATGCCACA TCACGCTAAA AATGAAGGAC AAAGCTTGGT CTTTCTCTTA GGGAGGATGA 6601 AACTCTGAAC CTCATTTTTC AGTTCCCAAG ATGAATTATG TTTCTCATTG CATCTGTGTT EPI-109 655

6661 CCACTACAGC TCCGCGTGAG AAGTACTGGC TACAATTTTT TATCCCATTG TTGGTGGTGA 6721 TTCTGTTTGC TGTGGACACA GGATTATTTA TCTCAACTCA GCAGCAGGTC ACATTTCTCT 6781 TGAAGATTAA GAGAACCAGG AAAGGCTTCA GACTTCTGAA CCCACATCCT AAGCCAAACC 6841 CCAAAAACAA CTGATATAAT TACTCAAGAA ATATTTGCAA CATTAGTTTT TTTCCAGCAT 6901 CAGCAATTGC TACTCAATTG TCAAACACAG CTTGCAATAT ACATAGAAAC GTCTGTGCTC 6961 AAGGATTTAT AGAAATGCTT CATTAAACTG AGTGAAACTG GTTAAGTGGC ATGTAATAGT 7021 AAGTGCTCAA TTAACATTGG TTGAATAAAT GAGAGAATGA ATAGATTCAT TTATTAGCAT 7081 TTGTAAAAGA GATGTTCAAT TTCAATAAAA TAAATATAAA ACCATGTAAC AGAATGCTTC 7141 TGAGTATTCA AGGCTTGCTA GTTTGTTTGT TTGTTTTCTA CTAAAGGCAA GGACCATGAA 7201 GTTCTAGATT GGAAATGTCC TCTCTTGACT ATTGCAAGTG CGATCTAGGA ATGAAAAGAC 7261 ATAGGAGGAT GCCAGTGAGG TGGATCATTT TTATGCTTCT TCTTCAGCTT ACTAAATATG 7321 AACTTTCAGT TCTTGGCAGA ATCAGGGACA GTCTCAAGAC ATAGGACTCT CAGGATGAAG 7381 TAGAGTCCAG GATTCCTCTG TGATTGTTTT GCCCCTCCCA AATTTATATC TTGAACTTAT 7441 GTCTTGTATC TTTATACAGC ACCTGAACCA AGCATTTTGG AGAAATTCCA GCTAATAATA 7501 ATAACCAAAA CCTTCGGCTC TGAAAACAGT CCAGGACTGA ATAAGATCTT GGGCAAAAGA 7561 ACTAGACAGT TTTGGTTTAT TTTCCCTTTC ATTTTATGTC TTCATCATAG TCATTGGAGG 7621 CTCATTCTTC TTGTCATGGA GTAAATGGGA TTAAAGTTC

(2) INFORMATION FOR SEQ ID NO: 2502: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1198 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2502:

1 TACTAAGAGT CTCCAGCATC CTCCACCTGT CTACCACCGA GCATGGGCCT ATATTTGAAG 61 CCTTAGATCT CTCCAGCACA GTAAGCACCA GGAGTCCATG AAGAAGATGG CTCCTGCCAT 121 GGAATCCCCT ACTCTACTGT GTGTAGCCTT ACTGTTCTTC GCTCCAGATG GCGTGTTAGC 181 AGTCCCTCAG AAACCTAAGG TCTCCTTGAA CCCTCCATGG AATAGAATAT TTAAAGGAGA 241 GAATGTGACT CTTACATGTA ATGGGAACAA TTTCTTTGAA GTCAGTTCCA CCAAATGGTT 301 CCACAATGGC AGCCTTTCAG AAGAGACAAA TTCAAGTTTG AATATTGTGA ATGCCAAATT

361 TGAAGACAGT GGAGAATACA AATGTCAGCA CCAACAAGTT AATGAGAGTG AACCTGTGTA 421 CCTGGAAGTC TTCAGTGACT GGCTGCTCCT TCAGGCCTCT GCTGAGGTGG TGATGGAGGG 481 CCAGCCCCTC TTCCTCAGGT GCCATGGTTG GAGGAACTGG GATGTGTACA AGGTGATCTA 541 TTATAAGGAT GGTGAAGCTC TCAAGTACTG GTATGAGAAC CACAACATCT CCATTACAAA 601 TGCCACAGTT GAAGACAGTG GAACCTACTA CTGTACGGGC AAAGTGTGGC AGCTGGACTA 661 TGAGTCTGAG CCCCTCAACA TTACTGTAAT AAAAGCTCCG CGTGAGAAGT ACTGGCTACA 721 ATTTTTTATC CCATTGTTGG TGGTGATTCT GTTTGCTGTG GACACAGGAT TATTTATCTC 781 AACTCAGCAG CAGGTCACAT TTCTCTTGAA GATTAAGAGA ACCAGGAAAG GCTTCAGACT 841 TCTGAACCCA CATCCTAAGC CAAACCCCAA AAACAACTGA TATAATTACT CAAGAAATAT 901 TTGCAACATT AGTTTTTTTC CAGCATCAGC AATTGCTACT CAATTGTCAA ACACAGCTTG 961 CAATATACAT AGAAACGTCT GTGCTCAAGG ATTTATAGAA ATGCTTCATT AAACTGAGTG

1021 AAACTGGTTA AGTGGCATGT AATAGTAAGT GCTCAATTAA CATTGGTTGA ATAAATGAGA 1081 GAATGAATAG ATTCATTTAT TAGCATTTGT AAAAGAGATG TTCAATTTCA ATAAAATAAA 1141 TATAAAACCA TGTAACAGAA TGCTTCTGAG TAAAAAAAAA AAAAAAAAAA AAAAAAAA

(2) INFORMATION FOR SEQ ID NO: 2503: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 894 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2503:

1 TCTCAATATA ATAATATTCT TTATTCCTGG ACAGCTCGGT TAATGAAAAA ATGGACACAG

61 AAAGTAATAG GAGAGCAAAT CTTGCTCTCC CACAGGAGCC TTCCAGTGTG CCTGCATTTG

121 AAGTCTTGGA AATATCTCCC CAGGAAGTAT CTTCAGGCAG ACTATTGAAG TCGGCCTCAT

181 CCCCACCACT GCATACATGG CTGACAGTTT TGAAAAAAGA GCAGGAGTTC CTGGGGGTAA

241 CACAAATTCT GACTGCTATG ATATGCCTTT GTTTTGGAAC AGTTGTCTGC TCTGTACTTG

301 ATATTTCACA CATTGAGGGA GACATTTTTT CATCATTTAA AGCAGGTTAT CCATTCTGGG

361 GAGCCATATT TTTTTCTATT TCTGGAATGT TGTCAATTAT ATCTGAAAGG AGAAATGCAA

421 CATATCTGGT GAGAGGAAGC CTGGGAGCAA ACACTGCCAG CAGCATAGCT GGGGGAACGG

481 GAATTACCAT CCTGATCATC AACCTGAAGA AGAGCTTGGC CTATATCCAC ATCCACAGTT 541 GCCAGAAATT TTTTGAGACC AAGTGCTTTA TGGCTTCCTT TTCCACTGAA ATTGTAGTGA 601 TGATGCTGTT TCTCACCATT CTGGGACTTG GTAGTGCTGT GTCACTCACA ATCTGTGGAG 661 CTGGGGAAGA ACTCAAAGGA AACAAGGTTC CAGAGGATCG TGTTTATGAA GAATTAAACA 721 TATATTCAGC TACTTACAGT GAGTTGGAAG ACCCAGGGGA AATGTCTCCT CCCATTGATT 781 TATAAGAATC ACGTGTCCAG AACACTCTGA TTCACAGCCA AGGATCCAGA AGGCCAAGGT 841 CTTGTTAAGG GGCTACTGGA AAAATTTCTA TTCTCTCCAC AGCCTGCTGG TTTT EPI-109 656

(2) INFORMATION FOR SEQ ID NO: 2504: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11298 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2504:

1 AAGCTTTTCA AAGGTGCAAT TGGATAACTT CTGCCATGAG AAATGGCTGA ATTGGGACAC

61 AAGTGGGGAC AATTCCAGAA GAAGGGCACA TCTCTTTCTT TTCTGCAGTT CTTTCTCACC

121 TTCTCAACTC CTACTAAAAT GTCTCATTTT CAGGTTCTGT AAATCCTGCT AGTCTCAGGC

181 AAAATTATGC TCCAGGAGTC TCAAATTTTC TTATTTCATA TTAGTCTTTA TTTAGTAGAC

241 TTCTCAATTT TTCTATTCAT CACAAGTAAA AGCCTGTTGA TCTTAATCAG CCAAGAAACT

301 TATCTGTCTG GCAAATGACT TATGTATAAA GAGAATCATC AATGTCATGA GGTAACCCAT

361 TTCAACTGCC TATTCAGAGC ATGCAGTAAG AGGAAATCCA CCAAGTCTCA ATATAATAAT

421 ATTCTTTATT CCTGGACAGC TCGGTTAATG AAAAAATGGA CACAGAAAGT AATAGGAGAG

481 CAAATCTTGC TCTCCCACAG GAGCCTTCCA GGTAGGTACA AGGTATTATT TTTTTCTACC

541 CTCAGTCACT TGTGGCAGGG GAAGTCATAG TCACGGTGCT TAGGAGATGA AACTTTATTG

601 ATTTAGGCAT GGATCCATCT AGTTTAATTA ATATATTGGG TATGAGGAAG CTACTTGCTG

661 TACTTTCCAT GTGGTTCTCT CTCCCTGGAG AGGAACATTT TTACTCAGCT TGCAAACTGG

721 AAATAGATTT TCTCACATTA GAAGCTCATT TTCTGGGTAT GAGACAGGAG AGTTCATACT

781 GTGTATGTAG ATCTCTGGCT TCTGGGTCTG ACATGTGCTG AGGGACACAT ATCCTTCACA

841 CATGCTTTTA TAAATACTTG ATAAAGTAAC CTGCTTCTTG ATTGGTCTTT ATAATCCATA

901 AGCTGTGGGA TGCTTCTCTG AAGATGAAAA TAGTAATAGA GTCCCATCTA GCTATTCAAA

961 GCCATTCCTT CATTGTATTC TGTGCACATG AAGTTGGGGT TTGTTACTGA CAAAATATAT

1021 TCAGATACAT TTCTATGTTA AAAGGATTGT GAGATGCATA GGTAAATGTG TTTATTTTCA

1081 GTTTTACTTG TCAACATAGA TGAATGAGAA AGAACTTGAA AGTAACACTG GATTAAGAAT

1141 AGGAAAATTT GGCATGGATT TTGCTCCATT TTGTCCCATC TAATCACTTG GATAGTGTTC

1201 AGGTGTTCTT GGTCAGTTAC TTGGATGCTC TGAGCTTTAG TTTCTTGGTG ATTACAATGA

1261 AGATTTGAAT TACAGGATGG CTTTGAAAAA ATAAACAAAA CTCCCCTTTC TGTCTGTCGA

1321 GAATGTTGCA CAGGGAGTTA CAGAATGTTC TCATGACTGA ATTGCTTTTA AATTTCACAG

1381 TGTGCCTGCA TTTGAAGTCT TGGAAATATC TCCCCAGGAA GTATCTTCAG GCAGACTATT

1441 GAAGTCGGCC TCATCCCCAC CACTGCATAC ATGGCTGACA GTTTTGAAAA AAGAGCAGGA

1501 GTTCCTGGGG GTGAGTGAGC CTCCTCCAAC TTTGACTAGA GTAAGGGTTG GGTCTAGAAA

1561 AGAATATTGA GTTGCATCAA CTGTTTTCCC ACTTGGATTC ATGAGAGGTG TTAGGTCCTT

1621 TAAAAAACAT GGTAGATAAA GAGTTGACAC TAACTGGGTC CTTTTGGGAA GAGCCAGAAG

1681 CATTTCCTCA TAAAGACTTT AAATTGCTAG GACGAGAATG GCCAACAGGA GTGAAGGATT

1741 CATAACTTTA TCTTTACTTA GATGTAAAGA ACAATTACTG ATGTTCAACA TGACTACATA

1801 CATAAAGGCG CATGGAGAAA AGTATTGGCC TTCCATGCAT TAGGTAGTGC TTGTATCAAT

1861 TCTTATAGTG GCTAGGGTAT CCTGGAAAAT CTTACGTGTG GATCATTTCT CAGGACAGTC

1921 TAGGACACTA ACGCAGTTTC TCATGTTTGG CTTCTATTAT TAAAAAATGA TACAATCTCG

1981 GGAAAATTTT TTTGATTTTC ATGAAATTCA TGTGTTTTTC TATAGGTAAC ACAAATTCTG

2041 ACTGCTATGA TATGCCTTTG TTTTGGAACA GTTGTCTGCT CTGTACTTGA TATTTCACAC

2101 ATTGAGGGAG ACATTTTTTC ATCATTTAAA GCAGGTTATC CATTCTGGGG AGCCATATTT

2161 GTGAGTATAT ATCTATAATT GTTTCTGAAA TAACACTGAA CATAGGTTTT TCTCTTTCTC

2221 AGATCTAACC AGTTGTTTAT TCCCAGTATT AAGATGATAT TTATAATTCT TAATTATAAA

2281 TATATGTGAG CATATATAAC ATAGATATGC TCATTAACAA CAACAAAAGA TTCTTTTTAC

2341 AATTAACGGT GGGTTAAACA TTTAGCCCAC AGTTTTATCC CATGAGAAAC CTGAATCTAA

2401 TACAAGTTAA ATGACTTGCC TAAGGGCCAC TTGACTAATA GTAATTGAAC CTAAACTTTC

2461 AGAATCCAAC TCCAGGAACA TACTTCTAGC ACTATTCATC AATAAAGTTA TATGATAAAT

2521 ACATACAACT TTATCTGTCA ACTAAAAATA ACAACAGAGG CTGGGCATGG TGGCTCACAC

2581 CCGTAATCCC AGCACTTTGG GAGGCTGAGG CAGGTGGATC ACCTGAGGTC AGGAGTTTGA

2641 GACCAGCCTG ACCAACATGG TGAAACCTCA TCTCTACTAA ATATAAAAAA TTAGCTGAGT

2701 GTGATAGTGC ATACCTGTAA TCCAGCTACT TAAGAGGCTG AGGCAGGAGG CTTGTTTGAA

2761 CCTGGAAGGC AGAGGTTGCA GTGAGCTGAG ATTGTGCCAT TGCACTCCAG CCTGGGCAAT

2821 AAGTGCGAAC TCTGTCTCAA AATAATAATA ATAATAATAG AAAATAAAGT TGTCTTCATG

2881 AAAAATGAGG AAAGAGATTG CTGGGGTGAG AAACATTAAG ATCAATGGGC ATATGGTGAC

2941 CTTCTATGCC CTAGAAACTC TTTTANGGTA TTTTCTCCTG GTATCTCTTT TACNCATCGT

3001 TCTATCTGGA AAAATAGGTG GATGAGTGAG ATAATAACGG TATATACTTT TTAAAGGTCT

3061 AATTGACATA TATAAATTGC AAGTATTTCA GATGTCAATT TGCTAACCTT GACACACATA

3121 GACACACATG AAAACATCAC CACATTAATA CAATGTATGT ATCCATCATT CCAAAAGCTT

3181 CCCTGTGTAT CTTTGTAACT CTTTCTTCCT CCCTCCACTC CTTGTCCTCT CGTTCCCAAG

3241 AAAACATTGA TCTGCTTCCT GTGAATATAA ATTAACTTAC ATTTTTTAGA GCTTTATATA

3301 AGTATGTTCT CTTTACTGTT TGTCTTCCTT CGCTGCACAG TTATTTTGAG ATTCTTCAAG

3361 TTTTTTCTTT ATATCGATAC TTCATTCACA AGAATATATT TTAATTCTAG ACTATGTCAC

3421 ATTGACTTTG TCGTCTGCTA AATCCTTAGT GCTCAGATGA CTTGTTCAGG ACTCTCCTTG

3481 AACCTGTACC TCTGTTANAT TGAAACTTGT CTCTACTGTC TTTTTATTTC AAACACAGCT

3541 TATTAGGTGT CTCTCAACCC ATCAAACNCA CAATCTGAGT CTTTAGGAGA TTGCTTTGAA

3601 TTTGTGCTAT TGACTTATAT NTATATNAAA TNTGTAAATG TTTGGTAAAA ATATCATCAT

3661 GTACNTTTTC ATAATTACGC TATNTNCACA TGATATATGT CAGACTCTGG AAATATGCAT EPI-109 657

3721 GCCACAGACA GGTGTTTCTT GCCTAAAGGG GCTGATGGAA GACNCACATA CNAATAGACG 3781 ATTGCAGTAG AATGAGAGTG GTGGTCTAAN CAGTACATGT CCTGATGTTG CTCGGACAGT 3841 TACTACNCCA AGAGTACCCC CTGCATTGTC AGGGTTAGCA TCTCCTGGAA GCCTCATGTA

3901 AATGAAGAAT TTCATGCTCC ATCCAGGACC TAATGAATAA GAATCTGCAT TTTAGCAAGA 3961 CCCTCATATG ATTCATA AC ACTTTTTTTT TTTTTTTTTA GATGGAGTCT CACTCTTGTC

4021 GCCCAGGCTG CAGTGCAATG GCATGATCTT GGCTCACTGC AACCTCTGCC TCCCGGGTTC 4081 AAGTGATTCT CCTGTCTCAG CCTCCCTAGT AGCTGGGACT ACAGGTGCAT GCCACAGTGG 4141 CTGGCTAATT TTTGTATTTT TAGTAGAGAC AGGGTTTCAC CATTTTGGTC AGGCTGGTCT 4201 TGAACTCATG ACCTCCGGTG ATTCCCCCGC CTCGGCTTCC CAAAGTGCTG GGATTACAGA 4261 CATGAGCCAC CACACCCGCC TTATTCGTAT ACNCATTTAA TTCTGAGAAG CACTCTATAG 4321 AAAATAAGAA TAAGAAAATA TTGGGCTCAC AGGTGACATT AATAAGTAAC TTTATCGAGT 4381 ACCCCAAATT TTACCTATGT TTGGAAGATG GGGTTAAAAG GACACATTGA AAACAAGAAC 4441 TCATTGTGGC TTTTTTTTCC TCCTTTTTGA ACAGTTTTCT ATTTCTGGAA TGTTGTCAAT 4501 TATATCTGAA AGGAGAAATG CAACATATCT GGTGAGTTGC CCGTTTCTGT CTTTGTCCAT 4561 CCTTGAAAAG ATAAGAAGAA CAGAGTTTTA AGAGTCTTAA GGGAAACACA TCTTTGTCTC 4621 CTATATTACT TGTGAATGTG GATATATGAT TTTGTTTCAA TCTATTTTGT GTCCTAAGGC 4681 TTTTTGCAAC AGAAGTTGGA TATATCATTA GAAACATAAA TTGTACCATT TAACATACAT 4741 GAAGTTTATG TTTACCTTGA CGTTCTTCTA AAAAGTGTCC TACACCGGCA TTGTCCTTGT 4801 AGGCATATTC ACATGATCAA ATAAAATAAT TAGTTTTCAA TTAAGGAGAA TATTTGAGGA 4861 AAGACCGTAC GTGTTCATGT GGTTCCTGAA GGCAGTCCAG TGAGAAAGTA ATATATGCTT 4921 CATTAAACAA TGCGGACATT TTCAGGGTTT CCCTTTTTAA CCAAAATTTG GAAGCAATGT 4981 GGAATTTACT GGATGCATCC AGCCCTGAAA TGAAGATAGG TTTATTGAAT GTGCCAGCAA 5041 GTGCAGGCCC AGGTCTGAGT GTTCTTCATT ATTATCAGGT GAGAGGAAGC CTGGGAGCAA 5101 ACACTGCCAG CAGCATAGCT GGGGGAACGG GAATTACCAT CCTGATCATC AACCTGAAGA 5161 AGAGCTTGGC CTATATCCAC ATCCACAGTT GCCAGAAATT TTTTGAGACC AAGTGCTTTA 5221 TGGCTTCCTT TTCCACTGTA TGTATTTTTT TTTGTGTGGG AAGACTAAGA TTCTGGGTCC 5281 TAATGTAAGT AAGAAGCCCT CTTCTCCTGT TCCATGAACA CCATCCTTTT CTGTAACTTC 5341 TATTACACAG TATAGTGGTT CTGTAAGTTC ACACAGCCCA GGGAGATGCT GGCTGCCCAC 5401 TCCCCTCAAC CCAGGCAAAT TCCTCGGGGT TAAAGTTATC TACTGCAAGT GACGATCTCT 5461 GGGTTTTTCT GTGCCTGTGT TTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTATGTGTCA 5521 CTTTAAAAGG ACTGGTCAGA TGGTAGGGAG ATGAAAACAG GAGATGCTAT AAGAAAATAA 5581 ACTTTTGGGG CGAATACCAA TGTGACTCTT TTTGTTTGTC ATTTGTTGCT GTTCAATAGG 5641 AAATTGTAGT GATGATGCTG TTTCTCACCA TTCTGGGACT TGGTAGTGCT GTGTCACTCA 5701 CAATCTGTGG AGCTGGGGAA GAACTCAAAG GAAACAAGGT AGATAGAAGC CCGATATAAA 5761 ATCTTGAATG ACAGGTTAAC GAATTGGAGC TTTATTCCTT AAAATATGGC CTGGGTTTTC 5821 TGAAACATTT CTTCCAGAAA ATAGTTTCTC CAAGTTTTAT TACTTTGGTT TACAAATCTC 5881 ACATTTAAAT CACATTTTAT ACCATAAGTA GCACACATTT CATAATATTC CTCTGAATGA 5941 GGGTTGGGAT AATAGGACTG ATATGTTAGA AATGCCTTAA AGTGTGTGGA GCATGAGAGA 6001 TGGATGTACA GAAGGCTTGT GAGGAAACCA CCCAGGTATC TGGCCTTGTT TTCTGCCCCA 6061 GAACTAGCCG CCTATTCCTG TTTCTGTTTT ATTCCTTTGT TTCTTGACTT TTCCTTTCCA 6121 ACTTGCTCTA AAACCTCAGT TTTCTTTCCT TTCTGATTCA TGACTACCAA ATGTTTTCAC 6181 TTGCCTCACC CGTCCATTAC ACCTTTGATA AGAACCACCA GACCTTGTGC TCATGTACTT 6241 GCCCATGTCT GATGGAAGAA ACATACTCTC TCCATCTGTC CACTTTCCTG AGGCATTCAA 6301 GTCTAGCCAC CTTTTAAAAT CACTCTCCTC CAGGCTGGGC ACGGTGTCAC GCCTGTAATC 6361 TCAGCACTTT GTGAGGCTGA GGAGGGCGGA TCACTTGAAG TCAGGAGTTC AAAACCAGCC 6421 TGGCCAAATG GCAAAACCAA ATCTTCTTCA ATTATAACCA AATCTTAAAC CAAATCTCTA 6481 CTAAAAAATA CAACAAAACA AAACAACAAC AACAAAAACA GAAAAGGAAA CATTAGCCCA 6541 GCGTGGTGGC AGGTACCTGA GGTTCCAGAT ACTTGGGAGG CTGAAGCAGG AGAATCGCTT 6601 GAGCCCAAGA GATGGAGGTT GCAGTGAGCC GAGATCATGC CACTGCACCA CAGCCAGGGT 6661 GACAGAGCCA TACTTCCCAG CACATTGGGA GGCCAAAGCT GAAGAATAAT TTGAGGTGAG 6721 GATTTGGAGA CCAGCCTGGC CAACATGGTG AAACTCCGTC TGTACTAAAA ATATAAAACT 6781 TAGTGGGGCA TGGGGGCACA CACCTGTAAT TTCAGCTACT TAGGAGGCTG AGGCAGGAGA 6841 ATTGCTTGAA CCCGGGAGGC GGAAGTTGCA GTGAGCCAAG ATCGTGGCCA CTGCACTCCA 6901 GCCTGGGTGA CATAGTGAGA TTCTGTCTCA AAAAAAATAA AAGAAATTTA AAAAATCACT 6961 CTCTTCCAAA GATAGATAAA TAAGACAGCA GATATACTAA GGAATAACCT CACCAACTTG 7021 TCATTGACTG ACATGATTTC TTTTGGCCCA CTTGGCCAGC TAGTCTGGTT TGGTTTTCTG 7081 GAAATGAAAG AAATAATCAG AGTTTAATGA CAGAGAGCGT GAGACCCAGA AAGACAAAAG 7141 TAGATGAGGT AAGTCTCTTG AGCGAGACTT CTAGGGATGG GAAATTTGTG GTGATTGATA 7201 TGAAATGATT TTTCCCTTAT CAGGTTCCAG AGGATCGTGT TTATGAAGAA TTAAACATAT 7261 ATTCAGCTAC TTACAGTGAG TTGGAAGACC CAGGGGAAAT GTCTCCTCCC ATTGATTTAT 7321 AAGAATCACG TGTCCAGAAC ACTCTGATTC ACAGCCAAGG ATCCAGAAGG CCAAGGTTTT 7381 GTTAAGGGGC TACTGGAAAA ATTTCTATTC TCTCCACAGC CTGCTGGTTT TACATTAGAT 7441 TTATTCGCCT GATAAGAATA TTTTGTTTCT GCTGCTTCTG TCCACCTTAA TATGCTCCTT 7501 CTATTTGTAG ATATGATAGA CTCCTATTTT TCTTGTTTTA TATTATGACC ACACACATCT 7561 CTGCTGGAAA GTCAACATGT AGTAAGCAAG ATTTAACTGT TTGATTATAA CTGTGCAAAT 7621 ACAGAAAAAA AGAAGGCTGG CTGAAAGTTG AGTTAAACTT TGACAGTTTG ATAATATTTG 7681 GTTCTTAGGG TTTTTTTTTT TTTTAGCATT CTTAATAGTT ACAGTTGGGC ATGATTTGTA 7741 CCATCCACCC ATACCCACAC AGTCACAGTC ACACACACAT ATGTATTACT TACACTATAT EPI-109 658

7801 ATAACTTCCT ATGCAAATAT TTTACCACCA GTCAATAATA CATTTTTGCC AAGACATGAA

7861 GTTTTATAAA GATCTGTATA ATTGCCTGAA TCACCAGCAC ATTCACTGAC ATGATATTAT

7 921 TTGCAGATTG ACAAGTAGGA AGTGGGGAAC TTTTATTAAG TTACTCGTTG TCTGGGGAGG

7981 TAAATAGGTT AAAAACAGGG AAATTATAAG TGCAGAGATT AACATTTCAC AAATGTTTAG 8041 TGAAACATTT GTGAAAAAAG AAGACTAAAT TAAGACCTGA GCTGAAATAA AGTGACGTGG 8101 AAATGGAAAT AATGGTTATA TCTAAAACAT GTAGAAAAAG AGTAACTGGT AGATTTTGTT 8161 AACAAATTAA AGAATAAAGT TAGACAAGCA ACTGGTTGAC TAATACATTA AGCGTTTGAG 8221 TCTAAGATGA AAGGAGAACA CTGGTTATGT TGATAGAATG ATAAAAAGGG TCGGGCGCGG 8281 AGGCTCACGC CTGTAATCCC AGCCCTTTGG GAGGCCGAGG TGGGCAGATC ACGAAGTCAG 8341 TAGTTTGAGA CCAGCCTGGC CAACATAGTG AAACCCCGTC TCTACTAAAA ATACAAAAAA

8401 AAAATTAGCT GGGTGTGGTG GCAGTCACCT GTAGTCCCAG CTACTTGGGA GGATGAGGCA 8461 GGAGAATCGC TTGAACCTGG GAGGCGGAGG TTGCAGTGAG CCGAGATCGC ACCAGTGCAC 8521 TCCAGCCTTG GTGACAATGG GAGACTCCAT CTCAAAAAAA AAAAAAAAAA AAAAAAGATA 8581 AAAAGTCAGA AATCTGAAAA GTGGAGGAAG AGTACAAATA GACCTAAATT AAGTCTCATT 8641 TTTTGGCTTT GATTTTGGGG AGACAAAGGG AAATGCAGCC ATAGAGGGCC TGATGACATC 8701 CAATACATGA GTTCTGGTAA AGATAAAATT TGATACACGG TTTGGTGTCA TTATAAGAGA 8761 AATCATTATT AAATGAAGCA AGTTAACACT CTAAGAGAAT TATTTTGAGA TAGAAGTGAA 8821 GCTAAGCTAA ACTTCACATG CCTATAATTG GAGGGAAAAA CTAAGGATAA AATCTAGCCT 8881 AGAAGATACA ATAATTAGTC ATAAACATGC ATTGTGAAAC TGTAGAGAGC AGGTAGCCCA 8941 AAATAGAGAA AGATTAGATA AAGAGAAAAT AAGTATCCAT CAGAGACAGT ATCTCTAGGC 9001 TTGGGCAAGA GAAAAGTCCA CAGTGATAAG CAACTCCACC TAAGGCATGA ATATGCGGCA 9061 GAGAAAACAG CAATAGTGAA TGAATGCAAA AGGTGCTGAG CAAATTCCAC ACATGAGTAT 9121 TGTGCATGAG TAAATGAATA AAACATTTGC AAAGACCTTT AGAGAAAGAG AATGGGAGCA 9181 TATGTGCGAA ATAAGATAGT TGATTATGAA TAGAAGGTAG TGAAGAAAAG CAAGCTAAGA 9241 AAAAATTCTG TTTATAAAAG AAGGAAAAGA TAGTTTATGT TTTTAGCCTA AGTATAAGAG 9301 TCCTACAGAT GGACTGAAAA AAATCAGTCT GAGAGTATTA GTCACAATTA ATGAAATAAT 9361 TACATTTTAT GTATTGAGGA TGCCAAGATT AAAAGGTGAC AGGTAGATGT TAATTTCCCT 9421 AGATTGTGAA AGTGATCACG ACAATCACAC AACAAATAAT TAAGTGACTT GGTATGCTTT 9481 ATTTAATTGT AGGGCCTGAG GTTTTCCATT CTCATTTTTC TAAAATACAA TTTTGTTTCT 9541 CCAAATTTGA CAGCAGAATA AAAACCCTAC CCTTTCACTG TGTATCATGC TAAGCTGCAT 9601 CTCTACTCTT GATCATCTGT AGGTATTAAT CACATCACTT CCATGGCATG GATGTTCACA 9661 TACAGACTCT TAACCCTGGT TTACCAGGAC CTCTAGGAGT GGATCCAATC TATATCTTTA 9721 CAGTTGTATA GTATATGATA TCTCTTTTAT TTCACTCAAT TTATATTTTC ATCATTGACT 9781 ACATATTTCT TATACACAAC ACACAATTTA TGAATTTTTT CTCAAGATCA TTCTGAGAGT 9841 TGCCCCACCC TACCTGCCTT TTATAGTACG CCCACCTCAG GCAGACACAG AGCACAATGC 9901 TGGGGTTCTC TTCACACTAT CACTGCCCCA AATTGTCTTT CTAAATTTCA ACTTCAATGT 9961 CATCTTCTCC ATGAAGACCA CTGAATGAAC ACCTTTTCAT CCAGCCTTAA TTTCTTGCTC

10021 CATAACTACT CTATCCCACG ATGCAGTATT GTATCATTAA TTATTAGTGT GCTTGTGACC 10081 TCCTTATGTA TTCTCAATTA CCTGTATTTG TGCAATAAAT TGGAATAATG TAACTTGATT 10141 TCTTATCTGT GTTTGTGTTG GCATGCAAGA TTTAGGTACT TATCAAGATA ATGGGGAATT 10201 AAGGCATCAA TAAAATGATG CCAAAGACCA AGAGCAGTTT CTGAAGTCCT CCTTTTCATC 10261 AGCTCTTTAT CAAACAGAAC ACTCTATAAA CAACCCATAG CCAGAAAACA GGATGTAGGA 10321 ACAATCACCA GCACACTCTA TAAACAACCC ATAGCCAGAA AACAGAATGT AAGGACAATC 10381 ACCAGCCATC TTTTGTCAAT AATTGATGGA ATAGAGTTGA AAGGAACTGG AGCATGAGTC 10441 ATATTTGACC AGTCAGTCCT CACTCTTATT TACTTGCTAT GTAAACTTGA GAAAGCTTTT 10501 TTCTCTTTGT GAACCTCAGG TTTTACATCT GAAAATGAGA AATTTGGAAC AAAAGATTCC 10561 TAACTGGTCT TTCTGTTCCC ATATTCTGTG ATTTTTCAAT ATTTAGGATT TTTGGTAATC 10621 ACAATTACTT AGTTTGTGGT TGAGATAGCA ACACGAATCA GAACTATTTG GTGGACATAT 10681 TTTCAAAGGA GTAGCTCTCC ACTTTGGGTA AAGAAGTGAT GCNGGTCGTG GTGGCTCACG 10741 CCTGTAATCC CAGCACTTTA GGGAGGCCAA GGCGGGTGGA TCACGAGGTC AGGAGATCGA 10801 GACCATCCTG GCTAACACGG TGAAACCCCG TCTCTACTAA AAAATACAAA AAATTAGCCA 10861 GGCGTGGTGG CGGGCGCCTG TAGTCCCACG TACTCGGGAG GCTGAGGCAG GAGAATGGCA 10921 TGAACCAGGG AGGCGGAGCT TGCCGTGAGC CGAGATAGCG CCACTGCAGT CCCTCCTGGG 10981 CAAAAGAGCA AGACTGCGTC TCAAAAAAAA AAAAAAAAAA AAAAAAAGAA GTGTGTGGAG 11041 TAGCAGGACA CCTGCAACAA TAATATTTTT CTAAATCCCT CTGAAAAATG CTAATCAAAG 11101 GGTTTTTTTC CTAAAAATTG TCTTAGAAAT AAAATTTCCC CTTTGGGAGA CCGAGGCTGG 11161 CAGATCACGA GGTCAGGAGA TAGAGACCAC GGTGAAACCC CGTCTCTACT AAAAATACTA 11221 AAAATTAGCC GGGGNGTGGT GGTGGGTACA CCTGTAGTCC CAGCTACTTG GAGGCTGAGG 11281 CTGGAGAATC ACGTGAAC

( 2 ) INFORMATION FOR SEQ ID NO : 2505 : ( l ) SEQUENCE CHARACTERISTICS :

(A) LENGTH : - base pairs

(B) TYPE : nucleic acid

(C) STRANDEDNESS : single

( D) TOPOLOGY : linear

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 2505 : 1 AACAAGAAAA GCGTTGGTAG CTCTGGTGAA TCCCAAAAGA ATGTGGCAGT TGCTAGCCAT

61 GCTCCTGAAT ATGTATAAAC AGTACATCAT ATGACTAAGA GTTTGACTTA GGGGTTAGAT EPI-109 659

121 TTTATGTGTT TGAACCCCAA ATTAGTTATT TAATAGTTGG CACCCCAAAA CAAGTTACTT 181 AACCTCACTA AGGTTCAGTT TTCCTGTTTA TAAAATGTAG ATAGTGATAG TATGTACTTT 241 ATAGGATTAT TGTGAAAAAT AAATGAAATA TCAGATTTAT TTAGGATAAC ACCTGGCATA 301 TGTTTGGTAT TCAGAATTAG TTGCTGCTGT TTTATTCTGC TCTCCCTTGC ATCCCACTTT

361 TCTAAGTTGT AAACTAAATA GTTGTACACA GATTGACAGA TTAAGAAAGG CTTGTGATTG

421 TGCTAGACCT ATGCCTATGC CTCTGTCTCA CCAGATTCCA GGTGTATATG TGGAGGTGGG 481 ATAGGGAGTG GAGTAAGTGG GTAAATATTA AATTGCCCAG TTGGGCACCA TCCTGAATAT 541 TATCTCTAAA GAAAGAAGCA AAACCAGGCA CAGCTGATGG GTTAACCAGA TATGATACAG 601 AAAACATTTC CTTCTGCTTT TTGGTTTTAA GCCTATATTT GAAGCCTTAG ATCTCTCCAG 661 CACAGTAAGC ACCAGGAGTC CATGAAGAAG ATG

694 GATCTTCATG TGGAATGACT GGTTTCATTC AATAGACTTA ATTCAGCAGT CTGTGGGGAA 754 GAGCAAGGTA TGATAGAATG GTTCCTCAAG TGCTTCAGAT GTGAAGTGGG TTTAAATATA 814 CTGTCCCTGT CTTCTTCAGA GTTTTGGTAA AGATAAAATA GGACACTCAT TTAAAAGCAA 874 TCTTTGCAAA TGACAAGCCA CTATAGACAT TAATAGAGTT TTCATTTCCA GTATTATCAT 934 TAATATCAGA TCCTGGAAGA AGGTTGAGCC TTGACCTAGA GCAAAAAAAC AGAAGAATTA 994 GTAAAGGAAT CCTGGAGAAA GCCCCTGCTG TGTATTTAAA GGAGAAAGGG AGATCATGTT 1054 GGGAAATTAT AATATTAAAA GTAAACAAAA GCTAGGAAGT AAAATAAAAT AAATTATATG 1114 GCCTAGATCC CCATAAGTAA TGGTTTAACT TCTGCCTTCC TGTGTTCTGA GCCAGATTAG 1174 GGCACAGTAG AGAAAGAGGA GTCTCTGAAA ATGTTTCCAA TTTCGCTGGT CAGACAGCGG 1234 ATCATCAGTG AATCAGATGA AAATTTGTGG ATTTATGCAC TAACTGATCA GCAGGAAATT 1294 AAACAAGAAA AGCGTTGGTA GCTCTGGTGA ATCCCAAAAG AATTTGGCAG TTGCTAGCCA 1354 TGCTCCTGAA TATGTATAAA CAGTACATCA TATGACTAAG AGTTTGACTT AGGGGTTAGA 1414 TTTTATGTGT TTGAACCCCA AATTAGTTAT TTAATAGTTG GCACCCCAAA ACAAGTTACT 1474 TAACCTCACT AAGATTCAGT TTTCCTGTTT ATAAAATGTA GATAGTGATA GTATGTACTT 1534 TATAGGATTA TTGTGAAAAA TAAATGAAAT ATCAGATTTA TTTAGGATAA CACCTGGCAT 1594 ATGTTTGGTA TTCAGTAATT AGTTGCTGCT GTTTTATTCT GCTCTCCCTT GCATCCCACT 1654 TTTCTAAGTT GTAAACTAAA TAGTTGTACA CAGATTGACA GATTAAGAAA GGCTTGTGAT 1714 TGTGCTAGAC CTATGCCTCT CTCTCACCAG ATTCCAGGTG TATATGTGGA GGTGGGATAG 1774 GGAGTGGAGT AAGTGGGTAA ATATTAAATT GCCCAGTTGG GCACCATCCT GAATATTATC 1834 TCTAAAGAAA GAAGCAAAAC CAGGCACAGC TGATGGGTTA ACCAGATATG ATACAGAAAA 1894 CATTTCCTTC TGCTTTTTGG TTTTAAGCCT ATATTTGAAG CCTTAGATCT CTCCAGCACA 1954 GTAAGCACCA GGAGTCCATG AAGAAGATGG CTCCTGCCAT GGAATCCCCT ACTCTACTGT 2014 GTGTAGCCTT ACTGTTCTTC GGTAAGTAGA GATTCAATTA CCCCTCCCAG GGAGGCCCAA 2074 ATGAATTTGG GGAGCAGCTG GGGTAGGAAC CTTTACTGTG GGTGGTGACT TTTTCTAGGA 2134 CATGTGCAAA CTATTGGGCA TTTCCCAGGG ACTCTGTAGT GGAGCCAAGC TAGAAAGCAG 2194 AGGCAAGTGG GCTGAGCAAC ACCTAAGGAG GAAGCCAGAC TGAAAGCTTG GTTCCTTGCA 2254 TTTGCTCTGG CATCTTCCAG AGTGCAAATT TCCTACCAAG GTAATGAGGG TAGAGGAGAG 2314 AAAGAAGCTC TTTCTTCCCC TGATTCTCAT TCCTGAAAAG ACGGTTGGTC CTTAAAATTC 2374 CATGGATGTA GATCTTATCC CCACACCCAG ATTCTAGTCC TCTGGAGATA AAGAAGACTG 2434 CTGGACACTA ATGTATCCTC TCTGGACTTT TGCAGCTCCA GATGGCGTGT TAGCAGGTGA 2494 GTCCTCTGTT CTTGTTCCCT TGGTGTATCA ACATGTCTGG GCATTGCTTT CCTCTCACTA 2554 TTTTCTTCGT CCCATCACTT CTGCTTTCTA ATGAGCATGA ATCTGTTCCT TGGCCAGACT 2634 ACTTTCCCTC TCCACCTTGC CTTGTCTTTC TTTTTTTCCC TGATTCATTG CATTCTCTCA 2694 AGTCATTCTC TCCTCTGTTT TAGTCAATAA CCATGTCTGT TGCACATATA CATGTCTCAT 2754 TCTCTCTCCT AGACACTTTG GCATGATCTC GCTCAATAAT TACATTATTA TTATTATTGC 2834 CATTTTATAA TTGAGGATGC TGAAACTCAG TGATTTTCTG GTGGTTACAT GGCTAAGGAA 2894 CTGGATTTCA ACGTAAGTTC CTTGGATCTA AGTCCAGTTC TCTTCTGACT ATATCACCCT 2954 TTTGTTATCA CCATGTATCT ACTTCTTTGG TCTCTGTTCA AATTTGCACT ACATCCCCTT 3014 GTTCCAGGAA GCCATTCAAG ACTGACTTTC TTAGTGCCTC TCACTACTTT CTGGAACTGA 3074 CATATGTTTT TCACTCTGTA TATACTTACA ATTAAATAGT CATAAATATT CAGAGCTTGG 3134 AGAAACCTTA TATTTCATCC AGTCCAGTAA ATTTATCCAT CCATAATTCA CTCATTCATT 3194 CACATAATAA ATATTTAATG TAACAATGGT TGAACATGGC AGACAGTGTT TCTACCTCAA 3274 AAGAGATTGC AGTCCTCATT TACAGATACT GAATTGAAAT TAACAGAAGT AGAGTGAGTC 3334 AGCTCAAATC ACATAGTGAA TTGGTTTCTT TGTTTTTAAA TCTCCTGCAT ATGTGTCCTG 3394 TCTTTCTCCC TGTGTTGGGC GTTCCCTGGG GCACCAATAC TAATTTCTCC TTCCCCTAGA 3454 AATCAAAACA GGGTCTTATC ACCAACAGAA TAAGGACAGG TTGACCACTG ATTGTCAGAA 3534 TATTGCTTCG TTTGTACTTT TAAGCCTAGA CAGTTTTCAA TGACTTTTTT TCTCTCTACA 3494 TGTCTTTTCA TATTTTTATC TTCTTGAAGT CCCTCAGAAA CCTAAGGTCT CCTTGAACCC 3554 TCCATGGAAT AGAATATTTA AAGGAGAGAA TGTGACTCTT ACATGTAATG GGAACAATTT 3614 CTTTGAAGTC AGTTCCACCA AATGGTTCCA CAATGGCAGC CTTTCAGAAG AGACAAATTC 3674 AAGTTTGAAT ATTGTGAATG CCAAATTTGA AGACAGTGGA GAATACAAAT GTCAGCACCA 3734 ACAAGTTAAT GAGAGTGAAC CTGTGTACCT GGAAGTCTTC AGTGGTAAGT TCCAGGGATA 3794 TGGAAATACA GATCTCTCAT GTGAGGGATG GCTCATCTGA AGATGGGAAA AAACAGGTTA 3854 TTCCAAGGGT TAGGACACCA GAGTGGGATT CAAGGCCTCT CATTTTTAAG ACCCCTGCAT

3934 TGGCTGGGCA CAGTGGCTCA CGCCTGTAAT CCCAGCACTT TGGGAGGCTG AGGCAGGTGG 3994 ATCACGAGGT CAGGAGATCG AGACCATCCG GCTAACATGG TGAAACCCCA TCTCTGCTAA

4054 AAAATATATA TATATAAAAT TAGCCGGGCG TAGTGGTGGG CACCTGTAGT CCCAGGTACT 4114 CGGGAGGCTG AGGCAGGAGA ATGGTGTGAA CCCAGGAGGT GGAGGTTGCA GTGAGCTGAG 4174 ATCACGCCAC TGCCCTCCAG CCTGGGCTAC AGAGCAAGAC TCCGTCTCAA AAAATAAATA EPI-109 660

4234 AATAAATAAA AAAGACCCCT GCATCTCTTT TCTTCTACCC CCTTCCCTTT TGATTACTTG 4294 TATGCCTTCT TTCAATATTC TAGTCATCTC TCAATATTAT TCCTCCACCC TATTTTCCTC 4354 TATCTTTTCT GCCTAGATTC AGGTATATAT TATGTGGTCA AACAGCATGA CATATATGTG 4414 AACATTTCAA AGAGCTGTGT ATCTGGAATA GGATCAAAAG GTTTGACTTA AAGTTTTGCT 4474 CTGCATAATC CATATGGCAG GACCTGAATA TTAGGTTGTA CTCTTCGTTA TGAAACATAT 4534 CTGGGTACAT TTCCTTATGT CCTCTGTTGT TACTTAAGAA CACATATTTC ATGCTTGTTT 4594 CATTTTTATC ACTCCTACTG CCAACAAATA GCATAGCATG CTTAGGCACA TGTGGCTTAA 4654 TTAGCAAATG TTGAATAAAC AAATTAATGA TTTTGAATAG TGACCAATAG GTCTCTTTTA 4714 TACTCTATAT TTTTCTCTTG AGTGAAAAAA AATGTTTCAA CCTCCATATG TAAATTCCAA 4774 ACACAAACTA AAGCAATGTA GAATAGCTTC TTTATTCCCT GGAGTAGGTT CTAGAGAAGT 4834 CCTAAAGGAT TGGTCCTAAA TTAATTATGC TTATTATGCT AGCGATATTT CCTTTCAAAA 4894 TTCTCCTTTA ATGAATGCTT TTTAATTTTT ACAAAAGCAT TAACCATAGA ATGTGATTCT

4954 TGTCTTTCAC TGACTCATTA GTGACAAATA TTTGTTGAGT ACCTACCAAC TCCTAAGTAT 5014 TGCTACCAAC TCCTAAATAC TGTGTTGGGC ATTCAGAATA GAATGTAGAA CTAGACAGGG 5074 TCCCTGACTT CTTGGAGCAC AGAGCAGTAT GGGAAGAGGA CATTAAATAA AGAATTACAT 5134 AAGTAATTAA TTTAAATTAT ACATGTTTTG AAGAAGTTTT TTTTTGACAA CTATAATTAA 5194 CACTAGAACT GGGAAGTTTC TATAAGGTAA GAGAGGACAA AATAGACACT CTCCTAAGCT 5254 AAAATTCCCA AGAAAGACTG TTTATTTTCC CCTAACTAAC TAGAACTAGC AACAGAAGAT 5314 CTGAAAGGAA TTCTGGCTTT CAAGTGTTCC ATGTATGGAC TCATCAGGGA GGTCCGAGAG 5474 GCTTTGTGGC CCCAGACTGA CTTTTCAGGA GGGGAAAGGA TTTATCAATA CACAAGACAG 5534 GCTCTAAGCA TTATTTTGTG CCCTTTAAAA ATCCACTTTA TGAGCCAAAA AGTGAGTTAA 5594 TGATAATTCA TAGTTTCTGA CACATGCTCT ATGCGTGGCT CTCTTTTCTC TATTCATTCT 5654 CTCTCTCTTC ATTTATTGTT AAATAAATAA TGTAATGAAT GTTCTTCAGA CTGGCTGCTC 5714 CTTCAGGCCT CTGCTGAGGT GGTGATGGAG GGCCAGCCCC TCTTCCTCAG GTGCCATGGT 5774 TGGAGGAACT GGGATGTGTA CAAGGTGATC TATTATAAGG ATGGTGAAGC TCTCAAGTAC 5834 TGGTATGAGA ACCACAACAT CTCCATTACA AATGCCACAG TTGAAGACAG TGGAACCTAC 5894 TACTGTACGG GCAAAGTGTG GCAGCTGGAC TATGAGTCTG AGCCCCTCAA CATTACTGTA

5954 ATAAAAGGTG AGTTGGTAAA GGAAAGGAAA AGCATCCATA GCAGGGGAAG GAAGAGAGAA 6014 CTTCTGAGCC TGAGCAGTTG CAGCTTGTAG AAGGGGGGCA CCTGTGATAC ACTGGAAAGC 6074 CTACCAGACT TGCAATGAGG AGACCTGGGT GATAGTATAT ATCTCAATCT CTGTTTCAAA 6134 GCCTTGACTT GTTAAATGGT GATAGTAATA CCTGCTTGCA CTATGAAATT TTTATGAAGA 6194 TTAATGTGGT AATATTTGTG AAATGACTTT GTAAACTGTT AAGCACTACC CAAGCATAAC 6254 AGATTGTGAT TACTATTTTG ATCTCAAAGT CATCTGTTGC TCCTGGGGGA ACACTTATAT 6314 TTATCAAATT GAAAAAAAGT TTCAAAGTTG AATGAAGAAA GGATATAAAG AGCTTGAGGA 6374 GCCCATTCCA GCTTAGGAGG GCTGGGAAAG GAAACCAGCA AGTCAGTAAG CTGTGTGCCT 6434 GTGTATTGAG GGAGGAGGGA ATGGACTTGA TATGGAGAGG GTAGGGAGGT GGACTGCCTC 6494 TATGGCCTGT AAGAAAAACT GCTCTCTCCA AACTCTTTAT AAGAGAGGGA GCCTGTGAAG 6554 TATTCACTTT TGAAGGAGAA AGTTAGACTT TTCCTTCACA CACTTTGTAC ATAATAATGT 6614 TTAAAAAAGC ATGAGGTCAA AATACATAAT TAAGTCCTAG CAGTTCTCTG TTAACTAATT 6674 TGAGACTGAA GTGCTATGTA CTTGTCTCTA GGCTTCCAGT ATCTTCATCT GTAAAACAGA 6734 ATATTTGGTC TAGATTCCAT TAGAATCATT TGATAACTTA AAAAATATAT TGATGCTCAT 6794 GTCTCATTTC TTGAGATTCT GATTTAATTG GTTTGGGGTG CAGCCTGGGT ATACGTATTT 6854 TTCATAGGTC TTTCACATAA TGGTAATGGG TAGCCAATAT TGAGAATCAC TTGTCTAGGT 6914 GATCTTTAAA TGATTTCTGG ATGTAATATT CTGAGGCTCT ATAATTTGAG ACTAATCACA 6974 AAAATCGGTA CAGTTTATAA ACAGACTAAC AGAACCACAA AATAATAGAA TTGGAAGGCA 7034 ATTTAACTAG TGCAATTTCT TCATTTTGCC TAACAGGCAT GTAAGAAATG ATGATTGATT 7094 GAGTAATAGG CATTGATGAC CCCTGTCCTC ACTTTGTCCC CTTTCCACCC CTTAATTATA 7154 TGTGAATTCT GGTCTTGTCA TTTCGAATAA GGGGTTTATC TTTCCTATTG TCTTCCCCTC 7214 TGGGCACGGC ACACTGGCTA CTGGAGTTAA GAGGAAATGC TTAGGACTCC CTGTGGCTCC 7274 AGGGAGCACC AACAGAGCAA CTCAACCTAG TGTTAATCTG AGTGTTTTCT CTGTGCTTCT 7334 GGATGCCACA TCACGCTAAA AATGAAGGAC AAAGCTTGGT CTTTCTCTTA GGGAGGATGA 7394 AACTCTGAAC CTCATTTTTC AGTTCCCAAG ATGAATTATG TTTCTCATTG CATCTGTGTT 7414 CCACTACAGC TCCGCGTGAG AAGTACTGGC TACAATTTTT TATCCCATTG TTGGTGGTGA 7474 TTCTGTTTGC TGTGGACACA GGATTATTTA TCTCAACTCA GCAGCAGGTC ACATTTCTCT 7534 TGAAGATTAA GAGAACCAGG AAAGGCTTCA GACTTCTGAA CCCACATCCT AAGCCAAACC 7594 CCAAAAACAA CTGATATAAT TACTCAAGAA ATATTTGCAA CATTAGTTTT TTTCCAGCAT 7654 CAGCAATTGC TACTCAATTG TCAAACACAG CTTGCAATAT ACATAGAAAC GTCTGTGCTC 7714 AAGGATTTAT AGAAATGCTT CATTAAACTG AGTGAAACTG GTTAAGTGGC ATGTAATAGT 7774 AAGTGCTCAA TTAACATTGG TTGAATAAAT GAGAGAATGA ATAGATTCAT TTATTAGCAT 7834. TTGTAAAAGA GATGTTCAAT TTCAATAAAA TAAATATAAA ACCATGTAAC AGAATGCTTC 7894 TGAGTATTCA AGGCTTGCTA GTTTGTTTGT TTGTTTTCTA CTAAAGGCAA GGACCATGAA 7954 GTTCTAGATT GGAAATGTCC TCTCTTGACT ATTGCAAGTG CGATCTAGGA ATGAAAAGAC 8014 ATAGGAGGAT GCCAGTGAGG TGGATCATTT TTATGCTTCT TCTTCAGCTT ACTAAATATG 8074 AACTTTCAGT TCTTGGCAGA ATCAGGGACA GTCTCAAGAC ATAGGACTCT CAGGATGAAG 8134 TAGAGTCCAG GATTCCTCTG TGATTGTTTT GCCCCTCCCA AATTTATATC TTGAACTTAT 8194 GTCTTGTATC TTTATACAGC ACCTGAACCA AGCATTTTGG AGAAATTCCA GCTAATAATA 8254 ATAACCAAAA CCTTCGGCTC TGAAAACAGT CCAGGACTGA ATAAGATCTT GGGCAAAAGA 8314 ACTAGACAGT TTTGGTTTAT TTTCCCTTTC ATTTTATGTC TTCATCATAG TCATTGGAGG EPI-109 661

8374 CTCATTCTTC TTGTCATGGA GTAAATGGGA TTAAAGTTC

8413 TACTAAGAGT CTCCAGCATC CTCCACCTGT CTACCACCGA GCATGGGCCT ATATTTGAAG 61 CCTTAGATCT CTCCAGCACA GTAAGCACCA GGAGTCCATG AAGAAGATGG CTCCTGCCAT 121 GGAATCCCCT ACTCTACTGT GTGTAGCCTT ACTGTTCTTC GCTCCAGATG GCGTGTTAGC 181 AGTCCCTCAG AAACCTAAGG TCTCCTTGAA CCCTCCATGG AATAGAATAT TTAAAGGAGA 241 GAATGTGACT CTTACATGTA ATGGGAACAA TTTCTTTGAA GTCAGTTCCA CCAAATGGTT 301 CCACAATGGC AGCCTTTCAG AAGAGACAAA TTCAAGTTTG AATATTGTGA ATGCCAAATT 361 TGAAGACAGT GGAGAATACA AATGTCAGCA CCAACAAGTT AATGAGAGTG AACCTGTGTA 421 CCTGGAAGTC TTCAGTGACT GGCTGCTCCT TCAGGCCTCT GCTGAGGTGG TGATGGAGGG 481 CCAGCCCCTC TTCCTCAGGT GCCATGGTTG GAGGAACTGG GATGTGTACA AGGTGATCTA 541 TTATAAGGAT GGTGAAGCTC TCAAGTACTG GTATGAGAAC CACAACATCT CCATTACAAA 601 TGCCACAGTT GAAGACAGTG GAACCTACTA CTGTACGGGC AAAGTGTGGC AGCTGGACTA 661 TGAGTCTGAG CCCCTCAACA TTACTGTAAT AAAAGCTCCG CGTGAGAAGT ACTGGCTACA 721 ATTTTTTATC CCATTGTTGG TGGTGATTCT GTTTGCTGTG GACACAGGAT TATTTATCTC 781 AACTCAGCAG CAGGTCACAT TTCTCTTGAA GATTAAGAGA ACCAGGAAAG GCTTCAGACT 841 TCTGAACCCA CATCCTAAGC CAAACCCCAA AAACAACTGA TATAATTACT CAAGAAATAT 901 TTGCAACATT AGTTTTTTTC CAGCATCAGC AATTGCTACT CAATTGTCAA ACACAGCTTG 961 CAATATACAT AGAAACGTCT GTGCTCAAGG ATTTATAGAA ATGCTTCATT AAACTGAGTG 1021 AAACTGGTTA AGTGGCATGT AATAGTAAGT GCTCAATTAA CATTGGTTGA ATAAATGAGA 1081 GAATGAATAG ATTCATTTAT TAGCATTTGT AAAAGAGATG TTCAATTTCA ATAAAATAAA 1141 TATAAAACCA TGTAACAGAA TGCTTCTGAG TAAAAAAAAA AAAAAAAAAA AAAAAAAA 1 TCTCAATATA ATAATATTCT TTATTCCTGG ACAGCTCGGT TAATGAAAAA ATGGACACAG 61 AAAGTAATAG GAGAGCAAAT CTTGCTCTCC CACAGGAGCC TTCCAGTGTG CCTGCATTTG 121 AAGTCTTGGA AATATCTCCC CAGGAAGTAT CTTCAGGCAG ACTATTGAAG TCGGCCTCAT 181 CCCCACCACT GCATACATGG CTGACAGTTT TGAAAAAAGA GCAGGAGTTC CTGGGGGTAA 241 CACAAATTCT GACTGCTATG ATATGCCTTT GTTTTGGAAC AGTTGTCTGC TCTGTACTTG 301 ATATTTCACA CATTGAGGGA GACATTTTTT CATCATTTAA AGCAGGTTAT CCATTCTGGG 361 GAGCCATATT TTTTTCTATT TCTGGAATGT TGTCAATTAT ATCTGAAAGG AGAAATGCAA 421 CATATCTGGT GAGAGGAAGC CTGGGAGCAA ACACTGCCAG CAGCATAGCT GGGGGAACGG 481 GAATTACCAT CCTGATCATC AACCTGAAGA AGAGCTTGGC CTATATCCAC ATCCACAGTT 541 GCCAGAAATT TTTTGAGACC AAGTGCTTTA TGGCTTCCTT TTCCACTGAA ATTGTAGTGA 601 TGATGCTGTT TCTCACCATT CTGGGACTTG GTAGTGCTGT GTCACTCACA ATCTGTGGAG 661 CTGGGGAAGA ACTCAAAGGA AACAAGGTTC CAGAGGATCG TGTTTATGAA GAATTAAACA 721 TATATTCAGC TACTTACAGT GAGTTGGAAG ACCCAGGGGA AATGTCTCCT CCCATTGATT 781 TATAAGAATC ACGTGTCCAG AACACTCTGA TTCACAGCCA AGGATCCAGA AGGCCAAGGT 841 CTTGTTAAGG GGCTACTGGA AAAATTTCTA TTCTCTCCAC AGCCTGCTGG TTTT

1 AAGCTTTTCA AAGGTGCAAT TGGATAACTT CTGCCATGAG AAATGGCTGA ATTGGGACAC

61 AAGTGGGGAC AATTCCAGAA GAAGGGCACA TCTCTTTCTT TTCTGCAGTT CTTTCTCACC

121 TTCTCAACTC CTACTAAAAT GTCTCATTTT CAGGTTCTGT AAATCCTGCT AGTCTCAGGC

181 AAAATTATGC TCCAGGAGTC TCAAATTTTC TTATTTCATA TTAGTCTTTA TTTAGTAGAC

241 TTCTCAATTT TTCTATTCAT CACAAGTAAA AGCCTGTTGA TCTTAATCAG CCAAGAAACT

301 TATCTGTCTG GCAAATGACT TATGTATAAA GAGAATCATC AATGTCATGA GGTAACCCAT

361 TTCAACTGCC TATTCAGAGC ATGCAGTAAG AGGAAATCCA CCAAGTCTCA ATATAATAAT

421 ATTCTTTATT CCTGGACAGC TCGGTTAATG AAAAAATGGA CACAGAAAGT AATAGGAGAG

481 CAAATCTTGC TCTCCCACAG GAGCCTTCCA GGTAGGTACA AGGTATTATT TTTTTCTACC

5 1 CTCAGTCACT TGTGGCAGGG GAAGTCATAG TCACGGTGCT TAGGAGATGA AACTTTATTG

601 ATTTAGGCAT GGATCCATCT AGTTTAATTA ATATATTGGG TATGAGGAAG CTACTTGCTG

661 TACTTTCCAT GTGGTTCTCT CTCCCTGGAG AGGAACATTT TTACTCAGCT TGCAAACTGG

721 AAATAGATTT TCTCACATTA GAAGCTCATT TTCTGGGTAT GAGACAGGAG AGTTCATACT

781 GTGTATGTAG ATCTCTGGCT TCTGGGTCTG ACATGTGCTG AGGGACACAT ATCCTTCACA

841 CATGCTTTTA TAAATACTTG ATAAAGTAAC CTGCTTCTTG ATTGGTCTTT ATAATCCATA

901 AGCTGTGGGA TGCTTCTCTG AAGATGAAAA TAGTAATAGA GTCCCATCTA GCTATTCAAA

961 GCCATTCCTT CATTGTATTC TGTGCACATG AAGTTGGGGT TTGTTACTGA CAAAATATAT

1021 TCAGATACAT TTCTATGTTA AAAGGATTGT GAGATGCATA GGTAAATGTG TTTATTTTCA

1081 GTTTTACTTG TCAACATAGA TGAATGAGAA AGAACTTGAA AGTAACACTG GATTAAGAAT

1141 AGGAAAATTT GGCATGGATT TTGCTCCATT TTGTCCCATC TAATCACTTG GATAGTGTTC

1201 AGGTGTTCTT GGTCAGTTAC TTGGATGCTC TGAGCTTTAG TTTCTTGGTG ATTACAATGA

1261 AGATTTGAAT TACAGGATGG CTTTGAAAAA ATAAACAAAA CTCCCCTTTC TGTCTGTCGA

1321 GAATGTTGCA CAGGGAGTTA CAGAATGTTC TCATGACTGA ATTGCTTTTA AATTTCACAG

1381 TGTGCCTGCA TTTGAAGTCT TGGAAATATC TCCCCAGGAA GTATCTTCAG GCAGACTATT

1441 GAAGTCGGCC TCATCCCCAC CACTGCATAC ATGGCTGACA GTTTTGAAAA AAGAGCAGGA

1501 GTTCCTGGGG GTGAGTGAGC CTCCTCCAAC TTTGACTAGA GTAAGGGTTG GGTCTAGAAA

1561 AGAATATTGA GTTGCATCAA CTGTTTTCCC ACTTGGATTC ATGAGAGGTG TTAGGTCCTT

1621 TAAAAAACAT GGTAGATAAA GAGTTGACAC TAACTGGGTC CTTTTGGGAA GAGCCAGAAG

1681 CATTTCCTCA TAAAGACTTT AAATTGCTAG GACGAGAATG GCCAACAGGA GTGAAGGATT

1741 CATAACTTTA TCTTTACTTA GATGTAAAGA ACAATTACTG ATGTTCAACA TGACTACATA 1801 CATAAAGGCG CATGGAGAAA AGTATTGGCC TTCCATGCAT TAGGTAGTGC TTGTATCAAT

1861 TCTTATAGTG GCTAGGGTAT CCTGGAAAAT CTTACGTGTG GATCATTTCT CAGGACAGTC EPI-109 662

1921 TAGGACACTA ACGCAGTTTC TCATGTTTGG CTTCTATTAT TAAAAAATGA TACAATCTCG 1981 GGAAAATTTT TTTGATTTTC ATGAAATTCA TGTGTTTTTC TATAGGTAAC ACAAATTCTG 2041 ACTGCTATGA TATGCCTTTG TTTTGGAACA GTTGTCTGCT CTGTACTTGA TATTTCACAC 2101 ATTGAGGGAG ACATTTTTTC ATCATTTAAA GCAGGTTATC CATTCTGGGG AGCCATATTT 2161 GTGAGTATAT ATCTATAATT GTTTCTGAAA TAACACTGAA CATAGGTTTT TCTCTTTCTC 2221 AGATCTAACC AGTTGTTTAT TCCCAGTATT AAGATGATAT TTATAATTCT TAATTATAAA 2281 TATATGTGAG CATATATAAC ATAGATATGC TCATTAACAA CAACAAAAGA TTCTTTTTAC 2341 AATTAACGGT GGGTTAAACA TTTAGCCCAC AGTTTTATCC CATGAGAAAC CTGAATCTAA 2401 TACAAGTTAA ATGACTTGCC TAAGGGCCAC TTGACTAATA GTAATTGAAC CTAAACTTTC 2461 AGAATCCAAC TCCAGGAACA TACTTCTAGC ACTATTCATC AATAAAGTTA TATGATAAAT 2521 ACATACAACT TTATCTGTCA ACTAAAAATA ACAACAGAGG CTGGGCATGG TGGCTCACAC 2581 CCGTAATCCC AGCACTTTGG GAGGCTGAGG CAGGTGGATC ACCTGAGGTC AGGAGTTTGA 2641 GACCAGCCTG ACCAACATGG TGAAACCTCA TCTCTACTAA ATATAAAAAA TTAGCTGAGT 2701 GTGATAGTGC ATACCTGTAA TCCAGCTACT TAAGAGGCTG AGGCAGGAGG CTTGTTTGAA 2761 CCTGGAAGGC AGAGGTTGCA GTGAGCTGAG ATTGTGCCAT TGCACTCCAG CCTGGGCAAT 2821 AAGTGCGAAC TCTGTCTCAA AATAATAATA ATAATAATAG AAAATAAAGT TGTCTTCATG 2881 AAAAATGAGG AAAGAGATTG CTGGGGTGAG AAACATTAAG ATCAATGGGC ATATGGTGAC 2941 CTTCTATGCC CTAGAAACTC TTTTANGGTA TTTTCTCCTG GTATCTCTTT TACNCATCGT 3001 TCTATCTGGA AAAATAGGTG GATGAGTGAG ATAATAACGG TATATACTTT TTAAAGGTCT 3061 AATTGACATA TATAAATTGC AAGTATTTCA GATGTCAATT TGCTAACCTT GACACACATA 3121 GACACACATG AAAACATCAC CACATTAATA CAATGTATGT ATCCATCATT CCAAAAGCTT 3181 CCCTGTGTAT CTTTGTAACT CTTTCTTCCT CCCTCCACTC CTTGTCCTCT CGTTCCCAAG 3241 AAAACATTGA TCTGCTTCCT GTGAATATAA ATTAACTTAC ATTTTTTAGA GCTTTATATA 3301 AGTATGTTCT CTTTACTGTT TGTCTTCCTT CGCTGCACAG TTATTTTGAG ATTCTTCAAG

3361 TTTTTTCTTT ATATCGATAC TTCATTCACA AGAATATATT TTAATTCTAG ACTATGTCAC 3421 ATTGACTTTG TCGTCTGCTA AATCCTTAGT GCTCAGATGA CTTGTTCAGG ACTCTCCTTG

3481 AACCTGTACC TCTGTTANAT TGAAACTTGT CTCTACTGTC TTTTTATTTC AAACACAGCT 3541 TATTAGGTGT CTCTCAACCC ATCAAACNCA CAATCTGAGT CTTTAGGAGA TTGCTTTGAA 3601 TTTGTGCTAT TGACTTATAT NTATATNAAA TNTGTAAATG TTTGGTAAAA ATATCATCAT 3661 GTACNTTTTC ATAATTACGC TATNTNCACA TGATATATGT CAGACTCTGG AAATATGCAT 3721 GCCACAGACA CGTGTTTCTT GCCTAAAGGG GCTGATGGAA GACNCACATA CNAATAGACG 3781 ATTGCAGTAG AATGAGAGTG GTGGTCTAAN CAGTACATGT CCTGATGTTG CTCGGACAGT 3841 TACTACNCCA AGAGTACCCC CTGCATTGTC AGGGTTAGCA TCTCCTGGAA GCCTCATGTA 3901 AATGAAGAAT TTCATGCTCC ATCCAGGACC TAATGAATAA GAATCTGCAT TTTAGCAAGA 3961 CCCTCATATG ATTCATATAC ACTTTTTTTT TTTTTTTTTA GATGGAGTCT CACTCTTGTC 4021 GCCCAGGCTG GAGTGCAATG GCATGATCTT GGCTCACTGC AACCTCTGCC TCCCGGGTTC 4081 AAGTGATTCT CCTGTCTCAG CCTCCCTAGT AGCTGGGACT ACAGGTGCAT GCCACAGTGG 4141 CTGGCTAATT TTTGTATTTT TAGTAGAGAC AGGGTTTCAC CATTTTGGTC AGGCTGGTCT 4201 TGAACTCATG ACCTCCGGTG ATTCCCCCGC CTCGGCTTCC CAAAGTGCTG GGATTACAGA 4261 CATGAGCCAC CACACCCGCC TTATTCGTAT ACNCATTTAA TTCTGAGAAG CACTCTATAG 4321 AAAATAAGAA TAAGAAAATA TTGGGCTCAC AGGTGACATT AATAAGTAAC TTTATCGAGT 4381 ACCCCAAATT TTACCTATGT TTGGAAGATG GGGTTAAAAG GACACATTGA AAACAAGAAC 4441 TCATTGTGGC TTTTTTTTCC TCCTTTTTGA ACAGTTTTCT ATTTCTGGAA TGTTGTCAAT 4501 TATATCTGAA AGGAGAAATG CAACATATCT GGTGAGTTGC CCGTTTCTGT CTTTGTCCAT 4561 CCTTGAAAAG ATAAGAAGAA CAGAGTTTTA AGAGTCTTAA GGGAAACACA TCTTTGTCTC 4621 CTATATTACT TGTGAATGTG GATATATGAT TTTGTTTCAA TCTATTTTGT GTCCTAAGGC 4681 TTTTTGCAAC AGAAGTTGGA TATATCATTA GAAACATAAA TTGTACCATT TAACATACAT 4741 GAAGTTTATG TTTACCTTGA CGTTCTTCTA AAAAGTGTCC TACACCGGCA TTGTCCTTGT 4801 AGGCATATTC ACATGATCAA ATAAAATAAT TAGTTTTCAA TTAAGGAGAA TATTTGAGGA 4861 AAGACCGTAC GTGTTCATGT GGTTCCTGAA GGCAGTCCAG TGAGAAAGTA ATATATGCTT 4921 CATTAAACAA TGCGGACATT TTCAGGGTTT CCCTTTTTAA CCAAAATTTG GAAGCAATGT 4981 GGAATTTACT GGATGCATCC AGCCCTGAAA TGAAGATAGG TTTATTGAAT GTGCCAGCAA 5041 GTGCAGGCCC AGGTCTGAGT GTTCTTCATT ATTATCAGGT GAGAGGAAGC CTGGGAGCAA 5101 ACACTGCCAG CAGCATAGCT GGGGGAACGG GAATTACCAT CCTGATCATC AACCTGAAGA 5161 AGAGCTTGGC CTATATCCAC ATCCACAGTT GCCAGAAATT TTTTGAGACC AAGTGCTTTA 5221 TGGCTTCCTT TTCCACTGTA TGTATTTTTT TTTGTGTGGG AAGACTAAGA TTCTGGGTCC 5281 TAATGTAAGT AAGAAGCCCT CTTCTCCTGT TCCATGAACA CCATCCTTTT CTGTAACTTC 5341 TATTACACAG TATAGTGGTT CTGTAAGTTC ACACAGCCCA GGGAGATGCT GGCTGCCCAC 5401 TCCCCTCAAC CCAGGCAAAT TCCTCGGGGT TAAAGTTATC TACTGCAAGT GACGATCTCT 5461 GGGTTTTTCT GTGCCTGTGT TTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTATGTGTCA 5521 CTTTAAAAGG ACTGGTCAGA TGGTAGGGAG ATGAAAACAG GAGATGCTAT AAGAAAATAA 5581 ACTTTTGGGG CGAATACCAA TGTGACTCTT TTTGTTTGTC ATTTGTTGCT GTTCAATAGG 5641 AAATTGTAGT GATGATGCTG TTTCTCACCA TTCTGGGACT TGGTAGTGCT GTGTCACTCA 5701 CAATCTGTGG AGCTGGGGAA GAACTCAAAG GAAACAAGGT AGATAGAAGC CCGATATAAA 5761 ATCTTGAATG ACAGGTTAAC GAATTGGAGC TTTATTCCTT AAAATATGGC CTGGGTTTTC 5821 TGAAACATTT CTTCCAGAAA ATAGTTTCTC CAAGTTTTAT TACTTTGGTT TACAAATCTC 5881 ACATTTAAAT CACATTTTAT ACCATAAGTA GCACACATTT CATAATATTC CTCTGAATGA 59 1 GGGTTGGGAT AATAGGACTG ATATGTTAGA AATGCCTTAA AGTGTGTGGA GCATGAGAGA EPI-109 663

6001 TGGATGTACA GAAGGCTTGT GAGGAAACCA CCCAGGTATC TGGCCTTGTT TTCTGCCCCA 6061 GAACTAGCCG CCTATTCCTG TTTCTGTTTT ATTCCTTTGT TTCTTGACTT TTCCTTTCCA 6121 ACTTGCTCTA AAACCTCAGT TTTCTTTCCT TTCTGATTCA TGACTACCAA ATGTTTTCAC 6181 TTGCCTCACC CGTCCATTAC ACCTTTGATA AGAACCACCA GACCTTGTGC TCATGTACTT 6241 GCCCATGTCT GATGGAAGAA ACATACTCTC TCCATCTGTC CACTTTCCTG AGGCATTCAA 6301 GTCTAGCCAC CTTTTAAAAT CACTCTCCTC CAGGCTGGGC ACGGTGTCAC GCCTGTAATC 6361 TCAGCACTTT GTGAGGCTGA GGAGGGCGGA TCACTTGAAG TCAGGAGTTC AAAACCAGCC 6421 TGGCCAAATG GCAAAACCAA ATCTTCTTCA ATTATAACCA AATCTTAAAC CAAATCTCTA 6481 CTAAAAAATA CAACAAAACA AAACAACAAC AACAAAAACA GAAAAGGAAA CATTAGCCCA 6541 GCGTGGTGGC AGGTACCTGA GGTTCCAGAT ACTTGGGAGG CTGAAGCAGG AGAATCGCTT 6601 GAGCCCAAGA GATGGAGGTT GCAGTGAGCC GAGATCATGC CACTGCACCA CAGCCAGGGT 6661 GACAGAGCCA TACTTCCCAG CACATTGGGA GGCCAAAGCT GAAGAATAAT TTGAGGTGAG 6721 GATTTGGAGA CCAGCCTGGC CAACATGGTG AAACTCCGTC TGTACTAAAA ATATAAAACT 6781 TAGTGGGGCA TGGGGGCACA CACCTGTAAT TTCAGCTACT TAGGAGGCTG AGGCAGGAGA 6841 ATTGCTTGAA CCCGGGAGGC GGAAGTTGCA GTGAGCCAAG ATCGTGGCCA CTGCACTCCA 6901 GCCTGGGTGA CATAGTGAGA TTCTGTCTCA AAAAAAATAA AAGAAATTTA AAAAATCACT 6961 CTCTTCCAAA GATAGATAAA TAAGACAGCA GATATACTAA GGAATAACCT CACCAACTTG 7021 TCATTGACTG ACATGATTTC TTTTGGCCCA CTTGGCCAGC TAGTCTGGTT TGGTTTTCTG 7081 GAAATGAAAG AAATAATCAG AGTTTAATGA CAGAGAGCGT GAGACCCAGA AAGACAAAAG 7141 TAGATGAGGT AAGTCTCTTG AGCGAGACTT CTAGGGATGG GAAATTTGTG GTGATTGATA 7201 TGAAATGATT TTTCCCTTAT CAGGTTCCAG AGGATCGTGT TTATGAAGAA TTAAACATAT 7261 ATTCAGCTAC TTACAGTGAG TTGGAAGACC CAGGGGAAAT GTCTCCTCCC ATTGATTTAT 7321 AAGAATCACG TGTCCAGAAC ACTCTGATTC ACAGCCAAGG ATCCAGAAGG CCAAGGTTTT 7381 GTTAAGGGGC TACTGGAAAA ATTTCTATTC TCTCCACAGC CTGCTGGTTT TACATTAGAT 7441 TTATTCGCCT GATAAGAATA TTTTGTTTCT GCTGCTTCTG TCCACCTTAA TATGCTCCTT 7501 CTATTTGTAG ATATGATAGA CTCCTATTTT TCTTGTTTTA TATTATGACC ACACACATCT 7561 CTGCTGGAAA GTCAACATGT AGTAAGCAAG ATTTAACTGT TTGATTATAA CTGTGCAAAT 7621 ACAGAAAAAA AGAAGGCTGG CTGAAAGTTG AGTTAAACTT TGACAGTTTG ATAATATTTG 7681 GTTCTTAGGG TTTTTTTTTT TTTTAGCATT CTTAATAGTT ACAGTTGGGC ATGATTTGTA 7741 CCATCCACCC ATACCCACAC AGTCACAGTC ACACACACAT ATGTATTACT TACACTATAT 7801 ATAACTTCCT ATGCAAATAT TTTACCACCA GTCAATAATA CATTTTTGCC AAGACATGAA 7861 GTTTTATAAA GATCTGTATA ATTGCCTGAA TCACCAGCAC ATTCACTGAC ATGATATTAT 7921 TTGCAGATTG ACAAGTAGGA AGTGGGGAAC TTTTATTAAG TTACTCGTTG TCTGGGGAGG

7981 TAAATAGGTT AAAAACAGGG AAATTATAAG TGCAGAGATT AACATTTCAC AAATGTTTAG 8041 TGAAACATTT GTGAAAAAAG AAGACTAAAT TAAGACCTGA GCTGAAATAA AGTGACGTGG 8101 AAATGGAAAT AATGGTTATA TCTAAAACAT GTAGAAAAAG AGTAACTGGT AGATTTTGTT 8161 AACAAATTAA AGAATAAAGT TAGACAAGCA ACTGGTTGAC TAATACATTA AGCGTTTGAG 8221 TCTAAGATGA AAGGAGAACA CTGGTTATGT TGATAGAATG ATAAAAAGGG TCGGGCGCGG 8281 AGGCTCACGC CTGTAATCCC AGCCCTTTGG GAGGCCGAGG TGGGCAGATC ACGAAGTCAG 8341 TAGTTTGAGA CCAGCCTGGC CAACATAGTG AAACCCCGTC TCTACTAAAA ATACAAAAAA 8401 AAAATTAGCT GGGTGTGGTG GCAGTCACCT GTAGTCCCAG CTACTTGGGA GGATGAGGCA 8461 GGAGAATCGC TTGAACCTGG GAGGCGGAGG TTGCAGTGAG CCGAGATCGC ACCAGTGCAC 8521 TCCAGCCTTG GTGACAATGG GAGACTCCAT CTCAAAAAAA AAAAAAAAAA AAAAAAGATA 8581 AAAAGTCAGA AATCTGAAAA GTGGAGGAAG AGTACAAATA GACCTAAATT AAGTCTCATT

8641 TTTTGGCTTT GATTTTGGGG AGACAAAGGG AAATGCAGCC ATAGAGGGCC TGATGACATC 8701 CAATACATGA GTTCTGGTAA AGATAAAATT TGATACACGG TTTGGTGTCA TTATAAGAGA 8761 AATCATTATT AAATGAAGCA AGTTAACACT CTAAGAGAAT TATTTTGAGA TAGAAGTGAA 8821 GCTAAGCTAA ACTTCACATG CCTATAATTG GAGGGAAAAA CTAAGGATAA AATCTAGCCT 8881 AGAAGATACA ATAATTAGTC ATAAACATGC ATTGTGAAAC TGTAGAGAGC AGGTAGCCCA 8941 AAATAGAGAA AGATTAGATA AAGAGAAAAT AAGTATCCAT CAGAGACAGT ATCTCTAGGC 9001 TTGGGCAAGA GAAAAGTCCA CAGTGATAAG CAACTCCACC TAAGGCATGA ATATGCGGCA 9061 GAGAAAACAG CAATAGTGAA TGAATGCAAA AGGTGCTGAG CAAATTCCAC ACATGAGTAT 9121 TGTGCATGAG TAAATGAATA AAACATTTGC AAAGACCTTT AGAGAAAGAG AATGGGAGCA 9181 TATGTGCGAA ATAAGATAGT TGATTATGAA TAGAAGGTAG TGAAGAAAAG CAAGCTAAGA 9241 AAAAATTCTG TTTATAAAAG AAGGAAAAGA TAGTTTATGT TTTTAGCCTA AGTATAAGAG 9301 TCCTACAGAT GGACTGAAAA AAATCAGTCT GAGAGTATTA GTCACAATTA ATGAAATAAT 9361 TACATTTTAT GTATTGAGGA TGCCAAGATT AAAAGGTGAC AGGTAGATGT TAATTTCCCT 9421 AGATTGTGAA AGTGATCACG ACAATCACAC AACAAATAAT TAAGTGACTT GGTATGCTTT 9481 ATTTAATTGT AGGGCCTGAG GTTTTCCATT CTCATTTTTC TAAAATACAA TTTTGTTTCT 9541 CCAAATTTGA CAGCAGAATA AAAACCCTAC CCTTTCACTG TGTATCATGC TAAGCTGCAT 9601 CTCTACTCTT GATCATCTGT AGGTATTAAT CACATCACTT CCATGGCATG GATGTTCACA 9661 TACAGACTCT TAACCCTGGT TTACCAGGAC CTCTAGGAGT GGATCCAATC TATATCTTTA 9721 CAGTTGTATA GTATATGATA TCTCTTTTAT TTCACTCAAT TTATATTTTC ATCATTGACT 9781 ACATATTTCT TATACACAAC ACACAATTTA TGAATTTTTT CTCAAGATCA TTCTGAGAGT 9841 TGCCCCACCC TACCTGCCTT TTATAGTACG CCCACCTCAG GCAGACACAG AGCACAATGC 9901 TGGGGTTCTC TTCACACTAT CACTGCCCCA AATTGTCTTT CTAAATTTCA ACTTCAATGT 9961 CATCTTCTCC ATGAAGACCA CTGAATGAAC ACCTTTTCAT CCAGCCTTAA TTTCTTGCTC

10021 CATAACTACT CTATCCCACG ATGCAGTATT GTATCATTAA TTATTAGTGT GCTTGTGACC EPI-109 664

10081 TCCTTATGTA TTCTCATTA CCTGTATTTG TGCAATAAAT TGGAATAATG TAACTTGATT 10141 TCTTATCTGT GTTTGTGTTG GCATGCAAGA TTTAGGTACT TATCAAGATA ATGGGGAATT, 10201 AAGGCATCAA TAAAATGATG CCAAAGACCA AGAGCAGTTT CTGAAGTCCT CCTTTTCATC 10261 AGCTCTTTAT CAAACAGAAC ACTCTATAAA CAACCCATAG CCAGAAAACA GGATGTAGGA 10321 ACAATCACCA GCACACTCTA TAAACAACCC ATAGCCAGAA AACAGAATGT AAGGACAATC 10381 ACCAGCCATC TTTTGTCAAT AATTGATGGA ATAGAGTTGA AAGGAACTGG AGCATGAGTC 10441 ATATTTGACC AGTCAGTCCT CACTCTTATT TACTTGCTAT GTAAACTTGA GAAAGCTTTT 10501 TTCTCTTTGT GAACCTCAGG TTTTACATCT GAAAATGAGA AATTTGGAAC AAAAGATTCC 10561 TAACTGGTCT TTCTGTTCCC ATATTCTGTG ATTTTTCAAT ATTTAGGATT TTTGGTAATC 10621 ACAATTACTT AGTTTGTGGT TGAGATAGCA ACACGAATCA GAACTATTTG GTGGACATAT 10681 TTTCAAAGGA GTAGCTCTCC ACTTTGGGTA AAGAAGTGAT GCNGGTCGTG GTGGCTCACG

10741 CCTGTAATCC CAGCACTTTA GGGAGGCCAA GGCGGGTGGA TCACGAGGTC AGGAGATCGA 10801 GACCATCCTG GCTAACACGG TGAAACCCCG TCTCTACTAA AAAATACAAA AAATTAGCCA

10861 GGCGTGGTGG CGGGCGCCTG TAGTCCCACG TACTCGGGAG GCTGAGGCAG GAGAATGGCA 10921 TGAACCAGGG AGGCGGAGCT TGCCGTGAGC CGAGATAGCG CCACTGCAGT CCCTCCTGGG 10981 CAAAAGAGCA AGACTGCGTC TCAAAAAAAA AAAAAAAAAA AAAAAAAGAA GTGTGTGGAG 11041 TAGCAGGACA CCTGCAACAA TAATATTTTT CTAAATCCCT CTGAAAAATG CTAATCAAAG 11101 GGTTTTTTTC CTAAAAATTG TCTTAGAAAT AAAATTTCCC CTTTGGGAGA CCGAGGCTGG 11161 CAGATCACGA GGTCAGGAGA TAGAGACCAC GGTGAAACCC CGTCTCTACT AAAAATACTA 11221 AAAATTAGCC GGGGNGTGGT GGTGGGTACA CCTGTAGTCC CAGCTACTTG GAGGCTGAGG 11281 CTGGAGAATC ACGTGAAC

(2) INFORMATION FOR SEQ ID NO: 2506: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1291 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2506:

1 CATATGTATG GGAATACTGT ATTTCAGGCA TTATAAGGAA TGAAATTATA GGCCGGGCAT

61 TGTGGCTAAC CCTTGTAATC CTAGCACTTT GAGAGGCTGA AGTGGGCAGA TCACTTGAGC

121 TTCAGAGTTC GAGACCAGCA TGGACAACAT GGTGAAACCC AGTCTCTACC AAAAACACAA

181 AAATATTAGC TGGGTGTGGT GGTGCATGCC TGTAGTCCCA GCTACTCAGG AGGCTGAGGT

241 GGGAGGATCG CTTGAGCCTG GGAGGCAGAA GTTGCAATGA GCAGAGATCG TGCCACTCCG

301 CTCCAGTCTT GGTGACAGAA TGAGACTCCA TCTCAAAAAT AAATAAATAA ATAAATAAAA

361 TAAATGAAAT GAAATTATAA GAAATTACCA CTTTTTCATG TAAGAAGTGA TCATTTCCAT

421 TATAAGGGAA GGAATTTAAT CCTACCTGCC ATTCCACCAA AGCTTACCTA GTGCTAAAGG

481 ATGAGGTGTT AGTAAGACCA ACATCTCAGA GGCCTCTCTG TGCCAATAGC CTTCCTTCCT

541 TTCCCTTCCA AAAACCTCAA GTGACTAGTT CAGAGGCCTG TCTGGAATAA TGGCATCATC

601 TAATATCACT GGCCTTCTGG AACCTGGGCA TTTTCCAGTG TGTTCCATAC TGTCAATATT

661 CCCCCAGCTT CCTGGACTCC TGTCACAAGC TGGAAAAGTG AGAGGATGGA CAGGGATTAA

721 CCAGAGAGCT CCCTGCTGAG GAAAAAATCT CCCAGATGCT GAAAGTGAGG CCATGTGGCT

781 TGGCCAAATA AAACCTGGCT CCGTGGTGCC TCTGTCTTAG CAGCCACCCT GCTGATGAAC

841 TGCCACCTTG GACTTGGGAC CAGAAAGAGG TGGGTTGGGT GAAGAGGCAC CACACAGAGT

901 GATGTAACAG CAAGATCAGG TCACCCACAG GCCCTGGCAG TCACAGTCAT AAATTAGCTA

961 ACTGTACACA AGCTGGGGAC ACTCCCTTTG GAAACCAAAA AAAAAAAAAA AAAAAAGAGA

1021 CCTTTATGCA AAAACAACTC TCTGGATGGC ATGGGGTGAG TATAAATACT TCTTGGCTGC

1081 CAGTGTGTTC ATAACTTTGT AGCGAGTCGA AAACTGAGGC TCCGGCCGCA GAGAACTCAG

1141 CCTCATTCCT GCTTTAAAAT CTCTCGGCCA CCTTTGATGA GGGGACTGGG CAGTTCTAGA

1201 CAGTCCCGAA GTTCTCAAGG CACAGGTCTC TTCCTGGTTT GACTGTCCTT ACCCCGGGGA

1261 GGCAGTGCAG CCAGCTGCAA GGTGAGTTGC C

(2) INFORMATION FOR SEQ ID NO:2507: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2507:

1 CTGCTTTAAA ATCTCTCGGC CACCTTTGAT GAGGGGACTG GGCAGTTCTA GACAGTCCCG 61 AAGTTCTCAA GGCACAGGTC TCTTCCTGGT TTGACTGTCC TTACCCCGGG GAGGCAGTGC 121 AGCCAGCTGC AAGCCCCACA GTGAAGAACA TCTGAGCTCA AATCCAGATA AGTGACATAA 181 GTGACCTGCT TTGTAAAGCC ATAGAGATGG CCTGTCCTTG GAAATTTCTG TTCAAGACCA 241 AATTCCACCA GTATGCAATG AATGGGGAAA AAGACATCAA CAACAATGTG GAGAAAGCCC 301 CCTGTGCCAC CTCCAGTCCA GTGACACAGG ATGACCTTCA GTATCACAAC CTCAGCAAGC 361 AGCAGAATGA GTCCCCGCAG CCCCTCGTGG AGACGGGAAA GAAGTCTCCA GAATCTCTGG 421 TCAAGCTGGA TGCAACCCCA TTGTCCTCCC CACGGCATGT GAGGATCAAA AACTGGGGCA 481 GCGGGATGAC TTTCCAAGAC ACACTTCACC ATAAGGCCAA AGGGATTTTA ACTTGCAGGT 541 CCAAATCTTG CCTGGGGTCC ATTATGACTC CCAAAAGTTT GACCAGAGGA CCCAGGGACA EPI-109 665

601 AGCCTACCCC TCCAGATGAG CTTCTACCTC AAGCTATCGA ATTTGTCAAC CAATATTACG 661 GCTCCTTCAA AGAGGCAAAA ATAGAGGAAC ATCTGGCCAG GGTGGAAGCG GTAACAAAGG 721 AGATAGAAAC AACAGGAACC TACCAACTGA CGGGAGATGA GCTCATCTTC GCCACCAAGC 781 AGGCCTGGCG CAATGCCCCA CGCTGCATTG GGAGGATCCA GTGGTCCAAC CTGCAGGTCT 841 TCGATGCCCG CAGCTGTTCC ACTGCCCGGG AAATGTTTGA ACACATCTGC AGACACGTGC 901 GTTACTCCAC CAACAATGGC AACATCAGGT CGGCCATCAC CGTGTTCCCC CAGCGGAGTG 961 ATGGCAAGCA CGACTTCCGG GTGTGGAATG CTCAGCTCAT CCGCTATGCT GGCTACCAGA 1021 TGCCAGATGG CAGCATCAGA GGGGACCCTG CCAACGTGGA ATTCACTCAG CTGTGCATCG 1081 ACCTGGGCTG GAAGCCCAAG TACGGCCGCT TCGATGTGGT CCCCCTGGTC CTGCAGGCCA 1141 ATGGCCGTGA CCCTGAGCTC TTCGAAATCC CACCTGACCT TGTGCTTGAG GTGGCCATGG 1201 AACATCCCAA ATACGAGTGG TTTCGGGAAC TGGAGCTAAA GTGGTACGCC CTGCCTGCAG 1261 TGGCCAACAT GCTGCTTGAG GTGGGCGGCC TGGAGTTCCC AGGGTGCCCC TTCAATGGCT 1321 GGTACATGGG CACAGAGATC GGAGTCCGGG ACTTCTGTGA CGTCCAGCGC TACAACATCC 1381 TGGAGGAAGT GGGCAGGAGA ATGGGCCTGG AAACGCACAA GCTGGCCTCG CTCTGGAAAG 1441 ACCAGGCTGT CGTTGAGATC AACATTGCTG TGATCCATAG TTTTCAGAAG CAGAATGTGA 1501 CCATCATGGA CCACCACTCG GCTGCAGAAT CCTTCATGAA GTACATGCAG AATGAATACC 1561 GGTCCCGTGG GGGCTGCCCG GCAGACTGGA TTTGGCTGGT CCCTCCCATG TCTGGGAGCA 1621 TCACCCCCGT GTTTCACCAG GAGATGCTGA ACTACGTCCT GTCCCCTTTC TACTACTATC 1681 AGGTAGAGGC CTGGAAAACC CATGTCTGGC AGGACGAGAA GCGGAGACCC AAGAGAAGAG 1741 AGATTCCATT GAAAGTCTTG GTCAAAGCTG TGCTCTTTGC CTGTATGCTG ATGCGCAAGA 1801 CAATGGCGTC CCGAGTCAGA GTCACCATCC TCTTTGCGAC AGAGACAGGA AAATCAGAGG 1861 CGCTGGCCTG GGACCTGGGG GCCTTATTCA GCTGTGCCTT CAACCCCAAG GTTGTCTGCA 1921 TGGATAAGTA CAGGCTGAGC TGCCTGGAGG AGGAACGGCT GCTGTTGGTG GTGACCAGTA 1981 CGTTTGGCAA TGGAGACTGC CCTGGCAATG GAGAGAAACT GAAGAAATCG CTCTTCATGC 2041 TGAAAGAGCT CAACAACAAA TTCAGGTACG CTGTGTTTGG CCTCGGCTCC AGCATGTACC 2101 CTCGGTTCTG CGCCTTTGCT CATGACATTG ATCAGAAGCT GTCCCACCTG GGGGCCTCTC 2161 AGCTCACCCC GATGGGAGAA GGGGATGAGC TCAGTGGGCA GGAGGACGCC TTCCGCAGCT 2221 GGGCCGTGCA AACCTTCAAG GCAGCCTGTG AGACGTTTGA TGTCCGAGGC AAACAGCACA 2281 TTCAGATCCC CAAGCTCTAC ACCTCCAATG TGACCTGGGA CCCGCACCAC TACAGGCTCG 2341 TGCAGGACTC ACAGCCTTTG GACCTCAGCA AAGCCCTCAG CAGCATGCAT GCCAAGAACG 2401 TGTTCACCAT GAGGCTCAAA TCTCGGCAGA ATCTACAAAG TCCGACATCC AGCCGTGCCA 2461 CCATCCTGGT GGAACTCTCC TGTGAGGATG GCCAAGGCCT GAACTACCTG CCGGGGGAGC 2521 ACCTTGGGGT TTGCCCAGGC AACCAGCCGG CCCTGGTCCA AGGCATCCTG GAGCGAGTGG 2581 TGGATGGCCC CACACCCCAC CAGACAGTGC GCCTGGAGGA CCTGGATGAG AGTGGCAGCT 2641 ACTGGGTCAG TGACAAGAGG CTGCCCCCCT GCTCACTCAG CCAGGCCCTC ACCTACTCCC 2701 CGGACATCAC CACACCCCCA ACCCAGCTGC TGCTCCAAAA GCTGGCCCAG GTGGCCACAG 2761 AAGAGCCTGA GAGACAGAGG CTGGAGGCCC TGTGCCAGCC CTCAGAGTAC AGCAAGTGGA 2821 AGTTCACCAA CAGCCCCACA TTCCTGGAGG TGCTAGAGGA GTTCCCGTCC CTGCGGGTGT 2881 CTGCTGGCTT CCTGCTTTCC CAGCTCCCCA TTCTGAAGCC CAGGTTCTAC TCCATCAGCT 2941 CCTCCCGGGA TCACACGCCC ACGGAGATCC ACCTGACTGT GGCCGTGGTC ACCTACCACA 3001 CCGGAGATGG CCAGGGTCCC CTGCACCACG GTGTCTGCAG CACATGGCTC AACAGCCTGA 3061 AGCCCCAAGA CCCAGTGCCC TGCTTTGTGC GGAATGCCAG CGCCTTCCAC CTCCCCGAGG 3121 ATCCCTCCCA TCCTTGCATC CTCATCGGGC CTGGCACAGG CATCGTGCCC TTCCGCAGTT 3181 TCTGGCAGCA ACGGCTCCAT GACTCCCAGC ACAAGGGAGT GCGGGGAGGC CGCATGACCT 3241 TGGTGTTTGG GTGCCGCCGC CCAGATGAGG ACCACATCTA CCAGGAGGAG ATGCTGGAGA 3301 TGGCCCAGAA GGGGGTGCTG CATGCGGTGC ACACAGCCTA TTCCCGCCTG CCTGGCAAGC 3361 CCAAGGTCTA TGTTCAGGAC ATCCTGCGGC AGCAGCTGGC CAGCGAGGTG CTCCGTGTGC 3421 TCCACAAGGA GCCAGGCCAC CTCTATGTTT GCGGGGATGT GCGCATGGCC CGGGACGTGG 3481 CCCACACCCT GAAGCAGCTG GTGGCTGCCA AGCTGAAATT GAATGAGGAG CAGGTCGAGG 3541 ACTATTTCTT TCAGCTCAAG AGCCAGAAGC GCTATCACGA AGATATCTTC GGTGCTGTAT 3601 TTCCTTACGA GGCGAAGAAG GACAGGGTGG CGGTGCAGCC CAGCAGCCTG GAGATGTCAG 3661 CGCTCTGAGG GCCTACAGGA GGGGTTAAAG CTGCCGGCAC AGAACTTAAG GATGGAGCCA 3721 GCTCTGCATT ATCTGAGGTC ACAGGGCCTG GGGAGATGGA GGAAAGTGAT ATCCCCCAGC 3781 CTCAAGTCTT ATTTCCTCAA CGTTGCTCCC CATCAAGCCC TTTACTTGAC CTCCTAACAA 3841 GTAGCACCCT GGATTGATCG GAGCCTCCTC TCTCAAACTG GGGCCTCCCT GGTCCCTTGG 3901 AGACAAAATC TTAAATGCCA GGCCTGGCGA GTGGGTGAAA GATGGAACTT GCTGCTGAGT 3961 GCACCACTTC AAGTGACCAC CAGGAGGTGC TATCGCACCA CTGTGTATTT AACTGCCTTG 4021 TGTACAGTTA TTTATGCCTC TGTATTTAAA AAACTAACAC CCAGTCTGTT CCCCATGGCC 4081 ACTTGGGTCT TCCCTGTATG ATTCCTTGAT GGAGATATTT ACATGAATTG CATTTTACTT 4141 TAATC

(2) INFORMATION FOR SEQ ID NO: 2508: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4077 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2508:

1 GAATTCCCAC TCTGCTGCCT GCTCCAGCAG ACGGACGCAC AGTAACATGG GCAACTTGAA EPI-109 666

61 GAGCGTGGCC CAGGAGCCTG GGCCACCCTG CGGCCTGGGG CTGGGGC'i'GG GCCTTGGGCT

121 GTGCGGCAAG CAGGGCCCAG CCACCCCGGC CCCTGAGCCC AGCCGGGCCC CAGCATCCCT

181 ACTCCCACCA GCGCCAGAAC ACAGCCCCCC GAGCTCCCCG CTAACCCAGC CCCCAGAGGG

241 GCCCAAGTTC CCTCGTGTGA AGAACTGGGA GGTGGGGAGC ATCACCTATG ACACCCTCAG

301 CGCCCAGGCG CAGCAGGATG GGCCCTGCAC CCCAAGACGC TGCCTGGGCT CCCTGGTATT

361 TCCACGGAAA CTACAGGGCC GGCCCTCCCC CGGCCCCCCG GCCCCTGAGC AGCTGCTGAG

421 TCAGGCCCGG GACTTCATCA ACCAGTACTA CAGCTCCATT AAGAGGAGCG GCTCCCAGGC

481 CCACGAACAG CGGCTTCAAG AGGTGGAAGC CGAGGTGGCA GCCACAGGCA CCTACCAGCT

541 TAGGGAGAGC GAGCTGGTGT TCGGGGCTAA GCAGGCCTGG CGCAACGCTC CCCGCTGCGT

601 GGGCCGGATC CAGTGGGGGA AGCTGCAGGT GTTCGATGCC CGGGACTGCA GGTCTGCACA

661 GGAAATGTTC ACCTACATCT GCAACCACAT CAAGTATGCC ACCAACCGGG GCAACCTTCG

721 CTCGGCCATC ACAGTGTTCC CGCAGCGCTG CCCTGGCCGA GGAGACTTCC GAATCTGGAA

781 CAGCCAGCTG GTGCGCTACG CGGGCTACCG GCAGCAGGAC GGCTCTGTGC GGGGGGACCC

841 AGCCAACGTG GAGATCACCG AGCTCTGCAT TCAGCACGGC TGGACCCCAG GAAACGGTCG

901 CTTCGACGTG CTGCCCCTGC TGCTGCAGGC CCCAGATGAG CCCCCAGAAC TCTTCCTTCT

961 GCCCCCCGAG CTGGTCCTTG AGGTGCCCCT GGAGCACCCC ACGCTGGAGT GGTTTGCAGC

1021 CCTGGGCCTG CGCTGGTACG CCCTCCCGGC AGTGTCCAAC ATGCTGCTGG AAATTGGGGG

1081 CCTGGAGTTC CCCGCAGCCC CCTTCAGTGG CTGGTACATG AGCACTGAGA TCGGCACGAG

1141 GAACCTGTGT GACCCTCACC GCTACAACAT CCTGGAGGAT GTGGCTGTCT GCATGGACCT

1201 GGATACCCGG ACCACCTCGT CCCTGTGGAA AGACAAGGCA GCAGTGGAAA TCAACGTGGC

1261 CGTGCTGCAC AGTTACCAGC TAGCCAAAGT CACCATCGTG GACCACCACG CCGCCACGGC

1321 CTCTTTCATG AAGCACCTGG AGAATGAGCA GAAGGCCAGG GGGGGCTGCC CTGCAGACTG

1381 GGCCTGGATC GTGCCCCCCA TCTCGGGCAG CCTCACTCCT GTTTTCCATC AGGAGATGGT

1441 CAACTATTTC CTGTCCCCGG CCTTCCGCTA CCAGCCAGAC CCCTGGAAGG GGAGTGCCGC

1501 CAAGGGCACC GGCATCACCA GGAAGAAGAC CTTTAAAGAA GTGGCCAACG CCGTGAAGAT

1561 CTCCGCCTCG CTCATGGGCA CGGTGATGGC GAAGCGAGTG AAGGCGACAA TCCTGTATGG

1621 CTCCGAGACC GGCCGGGCCC AGAGCTACGC ACAGCAGCTG GGGAGACTCT TCCGGAAGGC

1681 TTTTGATCCC CGGGTCCTGT GTATGGATGA GTATGACGTG GTGTCCCTCG AACACGAGAC

1741 GCTGGTGCTG GTGGTAACCA GCACATTTGG GAATGGGGAT CCCCCGGAGA ATGGAGAGAG

1801 CTTTGCAGCT GCCCTGATGG AGATGTCCGG CCCCTACAAC AGCTCCCCTC GGCCGGAACA

1861 GCACAAGAGT TATAAGATCC GCTTCAACAG CATCTCCTGC TCAGACCCAC TGGTGTCCTC

1921 TTGGCGGCGG AAGAGGAAGG AGTCCAGTAA CACAGACAGT GCAGGGGCCC TGGGCACCCT

1981 CAGGTTCTGT GTGTTCGGGC TCGGCTCCCG GGCATACCCC CACTTCTGCG CCTTTGCTCG

2041 TGCCGTGGAC ACACGGCTGG AGGAACTGGG CGGGGAGCGG CTGCTGCAGC TGGGCCAGGG

2101 CGACGAGCTG TGCGGCCAGG AGGAGGCCTT CCGAGGCTGG GCCCAGGCTG CCTTCCAGGC

2161 CGCCTGTGAG ACCTTCTGTG TGGGAGAGGA TGCCAAGGCC GCCGCCCGAG ACATCTTCAG

2221 CCCCAAACGG AGCTGGAAGC GCCAGAGGTA CCGGCTGAGC GCCCAGGCCG AGGGCCTGCA

2281 GTTGCTGCCA GGTCTGATCC ACGTGCACAG GCGGAAGATG TTCCAGGCTA CAATCCGCTC

2341 AGTGGAAAAC CTGCAAAGCA GCAAGTCCAC GAGGGCCACC ATCCTGGTGC GCCTGGACAC

2401 CGGAGGCCAG GAGGGGCTGC AGTACCAGCC GGGGGACCAC ATAGGTGTCT GCCCGCCCAA

2461 CCGGCCCGGC CTTGTGGAGG CGCTGCTGAG CCGCGTGGAG GACCCGCCGG CGCCCACTGA

2521 GCCCGTGGCA GTAGAGCAGC TGGAGAAGGG CAGCCCTGGT GGCCCTCCCC CCGGCTGGGT

2581 GCGGGACCCC CGGCTGCCCC CGTGCACGCT GCGCCAGGCT CTCACCTTCT TCCTGGACAT

2641 CACCTCCCCA CCCAGCCCTC AGCTCTTGCG GCTGCTCAGC ACCTTGGCAG AAGAGCCCAG

2701 GGAACAGCAG GAGCTGGAGG CCCTCAGCCA GGATCCCCGA CGCTACGAGG AGTGGAAGTG

2761 GTTCCGCTGC CCCACGCTGC TGGAGGTGCT GGAGCAGTTC CCGTCGGTGG CGCTGCCTGC

2821 CCCACTGCTC CTCACCCAGC TGCCTCTGCT CCAGCCCCGG TACTACTCAG TCAGCTCGGC

2881 ACCCAGCACC CACCCAGGAG AGATCCACCT CACTGTAGCT GTGCTGGCAT ACAGGACTCA

2941 GGATGGGCTG GGCCCCCTGC ACTATGGAGT CTGCTCCACG TGGCTAAGCC AGCTCAAGCC

3001 CGGAGACCCT GTGCCCTGCT TCATCCGGGG GGCTCCCTCC TTCCGGCTGC CACCCGATCC

3061 CAGCTTGCCC TGCATCCTGG TGGGTCCAGG CACTGGCATT GCCCCCTTCC GGGGATTCTG

3121 GCAGGAGCGG CTGCATGACA TTGAGAGCAA AGGGCTGCAG CCCACTCCCA TGACTTTGGT

3181 GTTCGGCTGC CGATGCTCCC AACTTGACCA TCTCTACCGC GACGAGGTGC AGAACGCCCA

3241 GCAGCGCGGG GTGTTTGGCC GAGTCCTCAC CGCCTTCTCC CGGGAACCTG ACAACCCCAA

3301 GACCTACGTG CAGGACATCC TGAGGACGGA GCTGGCTGCG GAGGTGCACC GCGTGCTGTG

3361 CCTCGAGCGG GGCCACATG TTGTCTGCGG CGATGTTACC ATGGCAACCA ACGTCCTGCA

3421 GACCGTGCAG CGCATCCTGG CGACGGAGGG CGACATGGAG CTGGACGAGG CCGGCGACGT

3481 CATCGGCGTG CTGCGGGATC AGCAACGCTA CCACGAAGAC ATTTTCGGGC TCACGCTGCG

3541 CACCCAGGAG GTGACAAGCC GCATACGCAC CCAGAGCTTT TCCTTGCAGG AGCGTCAGTT

3601 GCGGGGCGCA GTGCCCTGGG CGTTCGACCC TCCCGGCTCA GACACCAACA GCCCCTGAGA

3661 GCCGCCTGGC TTTCCCTTCC AGTTCCGGGA GAGCGGCTGC CCGACTCAGG TCCGCCCGAC

3721 CAGGATCAGC CCCGCTCCTC CCCTCTTGAG GTGGTGCCTT CTCACATCTG TCCAGAGGCT

3781 GCAAGGATTC AGCATTATTC CTCCAGGAAG GAGCAAAACG CCTCTTTTCC CTCTCTAGGC

3841 CTGTTGCCTC GGGCCTGGGT CCGCCTTAAT CTGGAAGGCC CCTCCCAGCA GCGGTACCCC

3901 AGGGCCTACT GCCACCCGCT TCCTGTTTCT TAGTCCGAAT GTTAGATTCC TCTTGCCTCT

3961 CTCAGGAGTA TCTTACCTGT AAAGTCTAAT CTCTAAATCA AGTATTTATT ATTGAAGATT

4021 TACCATAAGG GACTGTGCCA GATGTTAGGA GAACTACTAA AGTGCCTACC CCAGCTC EPI-109 667

(2) INFORMATION FOR SEQ ID NO: 2509: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2- base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2509: 1 CATATGTATG GGAATACTGT ATTTCAGGCA TTATAAGGAA TGAAATTATA GGCCGGGCAT

61 TGTGGCTAAC CCTTGTAATC CTAGCACTTT GAGAGGCTGA AGTGGGCAGA TCACTTGAGC 121 TTCAGAGTTC GAGACCAGCA TGGACAACAT GGTGAAACCC AGTCTCTACC AAAAACACAA 181 AAATATTAGC TGGGTGTGGT GGTGCATGCC TGTAGTCCCA GCTACTCAGG AGGCTGAGGT 241 GGGAGGATCG CTTGAGCCTG GGAGGCAGAA GTTGCAATGA GCAGAGATCG TGCCACTCCG 301 CTCCAGTCTT GGTGACAGAA TGAGACTCCA TCTCAAAAAT AAATAAATAA ATAAATAAAA

361 TAAATGAAAT GAAATTATAA GAAATTACCA CTTTTTCATG TAAGAAGTGA TCATTTCCAT 421 TATAAGGGAA GGAATTTAAT CCTACCTGCC ATTCCACCAA AGCTTACCTA GTGCTAAAGG

481 ATGAGGTGTT AGTAAGACCA ACATCTCAGA GGCCTCTCTG TGCCAATAGC CTTCCTTCCT 541 TTCCCTTCCA AAAACCTCAA GTGACTAGTT CAGAGGCCTG TCTGGAATAA TGGCATCATC 601 TAATATCACT GGCCTTCTGG AACCTGGGCA TTTTCCAGTG TGTTCCATAC TGTCAATATT

661 CCCCCAGCTT CCTGGACTCC TGTCACAAGC TGGAAAAGTG AGAGGATGGA CAGGGATTAA

721 CCAGAGAGCT CCCTGCTGAG GAAAAAATCT CCCAGATGCT GAAAGTGAGG CCATGTGGCT 781 TGGCCAAATA AAACCTGGCT CCGTGGTGCC TCTGTCTTAG CAGCCACCCT GCTGATGAAC 841 TGCCACCTTG GACTTGGGAC CAGAAAGAGG TGGGTTGGGT GAAGAGGCAC CACACAGAGT 901 GATGTAACAG CAAGATCAGG TCACCCACAG GCCCTGGCAG TCACAGTCAT AAATTAGCTA 961 ACTGTACACA AGCTGGGGAC ACTCCCTTTG GAAACCAAAA AAAAAAAAAA AAAAAAGAGA

1021 CCTTTATGCA AAAACAACTC TCTGGATGGC ATGGGGTGAG TATAAATACT TCTTGGCTGC 1081 CAGTGTGTTC ATAACTTTGT AGCGAGTCGA AAACTGAGGC TCCGGCCGCA GAGAACTCAG 1141 CCTCATTCCT GCTTTAAAAT CTCTCGGCCA CCTTTGATGA GGGGACTGGG CAGTTCTAGA 1201 CAGTCCCGAA GTTCTCAAGG CACAGGTCTC TTCCTGGTTT GACTGTCCTT ACCCCGGGGA 1261 GGCAGTGCAG CCAGCTGCAA GGTGAGTTGC C 1 CTGCTTTAAA ATCTCTCGGC CACCTTTGAT GAGGGGACTG GGCAGTTCTA GACAGTCCCG

61 AAGTTCTCAA GGCACAGGTC TCTTCCTGGT TTGACTGTCC TTACCCCGGG GAGGCAGTGC

121 AGCCAGCTGC AAGCCCCACA GTGAAGAACA TCTGAGCTCA AATCCAGATA AGTGACATAA

181 GTGACCTGCT TTGTAAAGCC ATAGAGATGG CCTGTCCTTG GAAATTTCTG TTCAAGACCA

241 AATTCCACCA GTATGCAATG AATGGGGAAA AAGACATCAA CAACAATGTG GAGAAAGCCC

301 CCTGTGCCAC CTCCAGTCCA GTGACACAGG ATGACCTTCA GTATCACAAC CTCAGCAAGC

361 AGCAGAATGA GTCCCCGCAG CCCCTCGTGG AGACGGGAAA GAAGTCTCCA GAATCTCTGG

421 TCAAGCTGGA TGCAACCCCA TTGTCCTCCC CACGGCATGT GAGGATCAAA AACTGGGGCA

481 GCGGGATGAC TTTCCAAGAC ACACTTCACC ATAAGGCCAA AGGGATTTTA ACTTGCAGGT

541 CCAAATCTTG CCTGGGGTCC ATTATGACTC CCAAAAGTTT GACCAGAGGA CCCAGGGACA

601 AGCCTACCCC TCCAGATGAG CTTCTACCTC AAGCTATCGA ATTTGTCAAC CAATATTACG

661 GCTCCTTCAA AGAGGCAAAA ATAGAGGAAC ATCTGGCCAG GGTGGAAGCG GTAACAAAGG

721 AGATAGAAAC AACAGGAACC TACCAACTGA CGGGAGATGA GCTCATCTTC GCCACCAAGC

781 AGGCCTGGCG CAATGCCCCA CGCTGCATTG GGAGGATCCA GTGGTCCAAC CTGCAGGTCT

841 TCGATGCCCG CAGCTGTTCC ACTGCCCGGG AAATGTTTGA ACACATCTGC AGACACGTGC

901 GTTACTCCAC CAACAATGGC AACATCAGGT CGGCCATCAC CGTGTTCCCC CAGCGGAGTG

961 ATGGCAAGCA CGACTTCCGG GTGTGGAATG CTCAGCTCAT CCGCTATGCT GGCTACCAGA

1021 TGCCAGATGG CAGCATCAGA GGGGACCCTG CCAACGTGGA ATTCACTCAG CTGTGCATCG

1081 ACCTGGGCTG GAAGCCCAAG TACGGCCGCT TCGATGTGGT CCCCCTGGTC CTGCAGGCCA

11 1 ATGGCCGTGA CCCTGAGCTC TTCGAAATCC CACCTGACCT TGTGCTTGAG GTGGCCATGG

1201 AACATCCCAA ATACGAGTGG TTTCGGGAAC TGGAGCTAAA GTGGTACGCC CTGCCTGCAG

1261 TGGCCAACAT GCTGCTTGAG GTGGGCGGCC TGGAGTTCCC AGGGTGCCCC TTCAATGGCT

1321 GGTACATGGG CACAGAGATC GGAGTCCGGG ACTTCTGTGA CGTCCAGCGC TACAACATCC

1381 TGGAGGAAGT GGGCAGGAGA ATGGGCCTGG AAACGCACAA GCTGGCCTCG CTCTGGAAAG

1441 ACCAGGCTGT CGTTGAGATC AACATTGCTG TGATCCATAG TTTTCAGAAG CAGAATGTGA

1501 CCATCATGGA CCACCACTCG GCTGCAGAAT CCTTCATGAA GTACATGCAG AATGAATACC

1561 GGTCCCGTGG GGGCTGCCCG GCAGACTGGA TTTGGCTGGT CCCTCCCATG TCTGGGAGCA

1621 TCACCCCCGT GTTTCACCAG GAGATGCTGA ACTACGTCCT GTCCCCTTTC TACTACTATC

1681 AGGTAGAGGC CTGGAAAACC CATGTCTGGC AGGACGAGAA GCGGAGACCC AAGAGAAGAG

1741 AGATTCCATT GAAAGTCTTG GTCAAAGCTG TGCTCTTTGC CTGTATGCTG ATGCGCAAGA

1801 CAATGGCGTC CCGAGTCAGA GTCACCATCC TCTTTGCGAC AGAGACAGGA AAATCAGAGG

1861 CGCTGGCCTG GGACCTGGGG GCCTTATTCA GCTGTGCCTT CAACCCCAAG GTTGTCTGCA

1921 TGGATAAGTA CAGGCTGAGC TGCCTGGAGG AGGAACGGCT GCTGTTGGTG GTGACCAGTA

1981 CGTTTGGCAA TGGAGACTGC CCTGGCAATG GAGAGAAACT GAAGAAATCG CTCTTCATGC

2041 TGAAAGAGCT CAACAACAAA TTCAGGTACG CTGTGTTTGG CCTCGGCTCC AGCATGTACC

2101 CTCGGTTCTG CGCCTTTGCT CATGACATTG ATCAGAAGCT GTCCCACCTG GGGGCCTCTC

2161 AGCTCACCCC GATGGGAGAA GGGGATGAGC TCAGTGGGCA GGAGGACGCC TTCCGCAGCT

2221 GGGCCGTGCA AACCTTCAAG GCAGCCTGTG AGACGTTTGA TGTCCGAGGC AAACAGCACA

2281 TTCAGATCCC CAAGCTCTAC ACCTCCAATG TGACCTGGGA CCCGCACCAC TACAGGCTCG

2341 TGCAGGACTC ACAGCCTTTG GACCTCAGCA AAGCCCTCAG CAGCATGCAT GCCAAGAACG EPI-109 668

2401 TGTTCACCAT GAGGCTCAAA TCTCGGCAGA ATCTACAAAG TCCGACATCC AGCCGTGCCA 2461 CCATCCTGGT GGAACTCTCC TGTGAGGATG GCCAAGGCCT GAACTACCTG CCGGGGGAGC 2521 ACCTTGGGGT TTGCCCAGGC AACCAGCCGG CCCTGGTCCA AGGCATCCTG GAGCGAGTGG 2581 TGGATGGCCC CACACCCCAC CAGACAGTGC GCCTGGAGGA CCTGGATGAG AGTGGCAGCT 2641 ACTGGGTCAG TGACAAGAGG CTGCCCCCCT GCTCACTCAG CCAGGCCCTC ACCTACTCCC 2701 CGGACATCAC CACACCCCCA ACCCAGCTGC TGCTCCAAAA GCTGGCCCAG GTGGCCACAG 2761 AAGAGCCTGA GAGACAGAGG CTGGAGGCCC TGTGCCAGCC CTCAGAGTAC AGCAAGTGGA 2821 AGTTCACCAA CAGCCCCACA TTCCTGGAGG TGCTAGAGGA GTTCCCGTCC CTGCGGGTGT 2881 CTGCTGGCTT CCTGCTTTCC CAGCTCCCCA TTCTGAAGCC CAGGTTCTAC TCCATCAGCT 2941 CCTCCCGGGA TCACACGCCC ACGGAGATCC ACCTGACTGT GGCCGTGGTC ACCTACCACA 3001 CCGGAGATGG CCAGGGTCCC CTGCACCACG GTGTCTGCAG CACATGGCTC AACAGCCTGA 3061 AGCCCCAAGA CCCAGTGCCC TGCTTTGTGC GGAATGCCAG CGCCTTCCAC CTCCCCGAGG 3121 ATCCCTCCCA TCCTTGCATC CTCATCGGGC CTGGCACAGG CATCGTGCCC TTCCGCAGTT 3181 TCTGGCAGCA ACGGCTCCAT GACTCCCAGC ACAAGGGAGT GCGGGGAGGC CGCATGACCT 3241 TGGTGTTTGG GTGCCGCCGC CCAGATGAGG ACCACATCTA CCAGGAGGAG ATGCTGGAGA 3301 TGGCCCAGAA GGGGGTGCTG CATGCGGTGC ACACAGCCTA TTCCCGCCTG CCTGGCAAGC 3361 CCAAGGTCTA TGTTCAGGAC ATCCTGCGGC AGCAGCTGGC CAGCGAGGTG CTCCGTGTGC 3421 TCCACAAGGA GCCAGGCCAC CTCTATGTTT GCGGGGATGT GCGCATGGCC CGGGACGTGG 3481 CCCACACCCT GAAGCAGCTG GTGGCTGCCA AGCTGAAATT GAATGAGGAG CAGGTCGAGG 3541 ACTATTTCTT TCAGCTCAAG AGCCAGAAGC GCTATCACGA AGATATCTTC GGTGCTGTAT 3601 TTCCTTACGA GGCGAAGAAG GACAGGGTGG CGGTGCAGCC CAGCAGCCTG GAGATGTCAG 3661 CGCTCTGAGG GCCTACAGGA GGGGTTAAAG CTGCCGGCAC AGAACTTAAG GATGGAGCCA 3721 GCTCTGCATT ATCTGAGGTC ACAGGGCCTG GGGAGATGGA GGAAAGTGAT ATCCCCCAGC 3781 CTCAAGTCTT ATTTCCTCAA CGTTGCTCCC CATCAAGCCC TTTACTTGAC CTCCTAACAA 3841 GTAGCACCCT GGATTGATCG GAGCCTCCTC TCTCAAACTG GGGCCTCCCT GGTCCCTTGG

3901 AGACAAAATC TTAAATGCCA GGCCTGGCGA GTGGGTGAAA GATGGAACTT GCTGCTGAGT 3961 GCACCACTTC AAGTGACCAC CAGGAGGTGC TATCGCACCA CTGTGTATTT AACTGCCTTG

4021 TGTACAGTTA TTTATGCCTC TGTATTTAAA AAACTAACAC CCAGTCTGTT CCCCATGGCC 4081 ACTTGGGTCT TCCCTGTATG ATTCCTTGAT GGAGATATTT ACATGAATTG CATTTTACTT 4141 TAATC

1 GAATTCCCAC TCTGCTGCCT GCTCCAGCAG ACGGACGCAC AGTAACATGG GCAACTTGAA

61 GAGCGTGGCC CAGGAGCCTG GGCCACCCTG CGGCCTGGGG CTGGGGCTGG GCCTTGGGCT

121 GTGCGGCAAG CAGGGCCCAG CCACCCCGGC CCCTGAGCCC AGCCGGGCCC CAGCATCCCT

181 ACTCCCACCA GCGCCAGAAC ACAGCCCCCC GAGCTCCCCG CTAACCCAGC CCCCAGAGGG

241 GCCCAAGTTC CCTCGTGTGA AGAACTGGGA GGTGGGGAGC ATCACCTATG ACACCCTCAG

301 CGCCCAGGCG CAGCAGGATG GGCCCTGCAC CCCAAGACGC TGCCTGGGCT CCCTGGTATT

361 TCCACGGAAA CTACAGGGCC GGCCCTCCCC CGGCCCCCCG GCCCCTGAGC AGCTGCTGAG

421 TCAGGCCCGG GACTTCATCA ACCAGTACTA CAGCTCCATT AAGAGGAGCG GCTCCCAGGC

481 CCACGAACAG CGGCTTCAAG AGGTGGAAGC CGAGGTGGCA GCCACAGGCA CCTACCAGCT

541 TAGGGAGAGC GAGCTGGTGT TCGGGGCTAA GCAGGCCTGG CGCAACGCTC CCCGCTGCGT

601 GGGCCGGATC CAGTGGGGGA AGCTGCAGGT GTTCGATGCC CGGGACTGCA GGTCTGCACA

661 GGAAATGTTC ACCTACATCT GCAACCACAT CAAGTATGCC ACCAACCGGG GCAACCTTCG

721 CTCGGCCATC ACAGTGTTCC CGCAGCGCTG CCCTGGCCGA GGAGACTTCC GAATCTGGAA

781 CAGCCAGCTG GTGCGCTACG CGGGCTACCG GCAGCAGGAC GGCTCTGTGC GGGGGGACCC

841 AGCCAACGTG GAGATCACCG AGCTCTGCAT TCAGCACGGC TGGACCCCAG GAAACGGTCG

901 CTTCGACGTG CTGCCCCTGC TGCTGCAGGC CCCAGATGAG CCCCCAGAAC TCTTCCTTCT

961 GCCCCCCGAG CTGGTCCTTG AGGTGCCCCT GGAGCACCCC ACGCTGGAGT GGTTTGCAGC

1021 CCTGGGCCTG CGCTGGTACG CCCTCCCGGC AGTGTCCAAC ATGCTGCTGG AAATTGGGGG

1081 CCTGGAGTTC CCCGCAGCCC CCTTCAGTGG CTGGTACATG AGCACTGAGA TCGGCACGAG

1141 GAACCTGTGT GACCCTCACC GCTACAACAT CCTGGAGGAT GTGGCTGTCT GCATGGACCT

1201 GGATACCCGG ACCACCTCGT CCCTGTGGAA AGACAAGGCA GCAGTGGAAA TCAACGTGGC

1261 CGTGCTGCAC AGTTACCAGC TAGCCAAAGT CACCATCGTG GACCACCACG CCGCCACGGC

1321 CTCTTTCATG AAGCACCTGG AGAATGAGCA GAAGGCCAGG GGGGGCTGCC CTGCAGACTG

1381 GGCCTGGATC GTGCCCCCCA TCTCGGGCAG CCTCACTCCT GTTTTCCATC AGGAGATGGT

1441 CAACTATTTC CTGTCCCCGG CCTTCCGCTA CCAGCCAGAC CCCTGGAAGG GGAGTGCCGC

1501 CAAGGGCACC GGCATCACCA GGAAGAAGAC CTTTAAAGAA GTGGCCAACG CCGTGAAGAT

1561 CTCCGCCTCG CTCATGGGCA CGGTGATGGC GAAGCGAGTG AAGGCGACAA TCCTGTATGG

1621 CTCCGAGACC GGCCGGGCCC AGAGCTACGC ACAGCAGCTG GGGAGACTCT TCCGGAAGGC

1681 TTTTGATCCC CGGGTCCTGT GTATGGATGA GTATGACGTG GTGTCCCTCG AACACGAGAC

1741 GCTGGTGCTG GTGGTAACCA GCACATTTGG GAATGGGGAT CCCCCGGAGA ATGGAGAGAG

1801 CTTTGCAGCT GCCCTGATGG AGATGTCCGG CCCCTACAAC AGCTCCCCTC GGCCGGAACA

1861 GCACAAGAGT TATAAGATCC GCTTCAACAG CATCTCCTGC TCAGACCCAC TGGTGTCCTC

1921 TTGGCGGCGG AAGAGGAAGG AGTCCAGTAA CACAGACAGT GCAGGGGCCC TGGGCACCCT

1981 CAGGTTCTGT GTGTTCGGGC TCGGCTCCCG GGCATACCCC CACTTCTGCG CCTTTGCTCG

2041 TGCCGTGGAC ACACGGCTGG AGGAACTGGG CGGGGAGCGG CTGCTGCAGC TGGGCCAGGG

2101 CGACGAGCTG TGCGGCCAGG AGGAGGCCTT CCGAGGCTGG GCCCAGGCTG CCTTCCAGGC

2161 CGCCTGTGAG ACCTTCTGTG TGGGAGAGGA TGCCAAGGCC GCCGCCCGAG ACATCTTCAG

2221 CCCCAAACGG AGCTGGAAGC GCCAGAGGTA CCGGCTGAGC GCCCAGGCCG AGGGCCTGCA EPI-109 669

2281 GTTGCTGCCA GGTCTGATCC ACGTGCACAG GCGGAAGATG TTCCAGGCTA CAATCCGCTC

2341 AGTGGAAAAC CTGCAAAGCA GCAAGTCCAC GAGGGCCACC ATCCTGGTGC GCCTGGACAC

2401 CGGAGGCCAG GAGGGGCTGC AGTACCAGCC GGGGGACCAC ATAGGTGTCT GCCCGCCCAA

24 61 CCGGCCCGGC CTTGTGGAGG CGCTGCTGAG CCGCGTGGAG GACCCGCCGG CGCCCACTGA

2521 GCCCGTGGCA GTAGAGCAGC TGGAGAAGGG CAGCCCTGGT GGCCCTCCCC CCGGCTGGGT

2581 GCGGGACCCC CGGCTGCCCC CGTGCACGCT GCGCCAGGCT CTCACCTTCT TCCTGGACAT

2641 CACCTCCCCA CCCAGCCCTC AGCTCTTGCG GCTGCTCAGC ACCTTGGCAG AAGAGCCCAG

2701 GGAACAGCAG GAGCTGGAGG CCCTCAGCCA GGATCCCCGA CGCTACGAGG AGTGGAAGTG

2761 GTTCCGCTGC CCCACGCTGC TGGAGGTGCT GGAGCAGTTC CCGTCGGTGG CGCTGCCTGC

2821 CCCACTGCTC CTCACCCAGC TGCCTCTGCT CCAGCCCCGG TACTACTCAG TCAGCTCGGC

2881 ACCCAGCACC CACCCAGGAG AGATCCACCT CACTGTAGCT GTGCTGGCAT ACAGGACTCA

2941 GGATGGGCTG GGCCCCCTGC ACTATGGAGT CTGCTCCACG TGGCTAAGCC AGCTCAAGCC

3001 CGGAGACCCT GTGCCCTGCT TCATCCGGGG GGCTCCCTCC TTCCGGCTGC CACCCGATCC

3061 CAGCTTGCCC TGCATCCTGG TGGGTCCAGG CACTGGCATT GCCCCCTTCC GGGGATTCTG

3121 GCAGGAGCGG CTGCATGACA TTGAGAGCAA AGGGCTGCAG CCCACTCCCA TGACTTTGGT

3181 GTTCGGCTGC CGATGCTCCC AACTTGACCA TCTCTACCGC GACGAGGTGC AGAACGCCCA

3241 GCAGCGCGGG GTGTTTGGCC GAGTCCTCAC CGCCTTCTCC CGGGAACCTG ACAACCCCAA

3301 GACCTACGTG CAGGACATCC TGAGGACGGA GCTGGCTGCG GAGGTGCACC GCGTGCTGTG

3361 CCTCGAGCGG GGCCACATGT TTGTCTGCGG CGATGTTACC ATGGCAACCA ACGTCCTGCA

3421 GACCGTGCAG CGCATCCTGG CGACGGAGGG CGACATGGAG CTGGACGAGG CCGGCGACGT

3481 CATCGGCGTG CTGCGGGATC AGCAACGCTA CCACGAAGAC ATTTTCGGGC TCACGCTGCG

3541 CACCCAGGAG GTGACAAGCC GCATACGCAC CCAGAGCTTT TCCTTGCAGG AGCGTCAGTT

3601 GCGGGGCGCA GTGCCCTGGG CGTTCGACCC TCCCGGCTCA GACACCAACA GCCCCTGAGA

3661 GCCGCCTGGC TTTCCCTTCC AGTTCCGGGA GAGCGGCTGC CCGACTCAGG TCCGCCCGAC

3721 CAGGATCAGC CCCGCTCCTC CCCTCTTGAG GTGGTGCCTT CTCACATCTG TCCAGAGGCT

3781 GCAAGGATTC AGCATTATTC CTCCAGGAAG GAGCAAAACG CCTCTTTTCC CTCTCTAGGC

3841 CTGTTGCCTC GGGCCTGGGT CCGCCTTAAT CTGGAAGGCC CCTCCCAGCA GCGGTACCCC

3901 AGGGCCTACT GCCACCCGCT TCCTGTTTCT TAGTCCGAAT GTTAGATTCC TCTTGCCTCT

3961 CTCAGGAGTA TCTTACCTGT AAAGTCTAAT CTCTAAATCA AGTATTTATT ATTGAAGATT

4021 TACCATAAGG GACTGTGCCA GATGTTAGGA GAACTACTAA AGTGCCTACC CCAGCTC

( 2 ) INFORMATION FOR SEQ ID- NO : 2510 : ( i ) SEQUENCE CHARACTERISTICS :

(A) LENGTH : 11970 base pairs

(B) TYPE : nucleic acid

(C) STRANDEDNESS : single

( D) TOPOLOGY : linear

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 2510 : 1 AAGCTTCTAC CCTAGTCTGG TGCTACACTT ACATTGCTTA CATCCAAGTG TGGTTATTTC

61 TGTGGCTCCT GTTATAACTA TTATAGCACC AGGTCTATGA CCAGGAGAAT TAGACTGGCA

121 TTAAATCAGA ATAAGAGATT TTGCACCTGC AATAGACCTT ATGACACCTA ACCAACCCCA

181 TTATTTACAA TTAAACAGGA ACAGAGGGAA TACTTTATCC AACTCACACA AGCTGTTTTC

241 CTCCCAGATC CATGCTTTTT TGCGTTTATT ATTTTTTAGA GATGGGGGCT TCACTATGTT

301 GCCCACACTG GACTAAAACT CTGGGCCTCA AGTGATTGTC CTGCCTCAGC CTCCTGAATA

361 GCTGGGACTA CAGGGGCATG CCATCACACC TAGTTCATTT CCTCTATTTA AAATATACAT

421 GGCTTAAACT CCAACTGGGA ACCCAAAACA TTCATTTGCT AAGAGTCTGG TGTTCTACCA

481 CCTGAACTAG GCTGGCCACA GGAATTATAA AAGCTGAGAA ATTCTTTAAT AATAGTAACC

541 AGGCAACATC ATTGAAGGCT CATATGTAAA AATCCATGCC TTCCTTTCTC CCAATCTCCA

601 TTCCCAAACT TAGCCACTGG TTCTGGCTGA GGCCTTACGC ATACCTCCCG GGGCTTGCAC

661 ACACCTTCTT CTACAGAAGA CACACCTTGG GCATATCCTA CAGAAGACCA GGCTTCTCTC

721 TGGTCCTTGG TAGAGGGCTA CTTTACTGTA ACAGGGCCAG GGTGGAGAGT TCTCTCCTGA

781 AGCTCCATCC CCTCTATAGG AAATGTGTTG ACAATATTCA GAAGAGTAAG AGGATCAAGA

841 CTTCTTTGTG CTCAAATACC ACTGTTCTCT TCTCTACCCT GCCCTAACCA GGAGCTTGTC

901 ACCCCAAACT CTGAGGTGAT TTATGCCTTA ATCAAGCAAA CTTCCCTCTT CAGAAAAGAT

961 GGCTCATTTT CCCTCAAAAG TTGCCAGGAG CTGCCAAGTA TTCTGCCAAT TCACCCTGGA

1021 GCACAATCAA CAAATTCAGC CAGAACACAA CTACAGCTAC TATTAGAACT ATTATTATTA

1081 ATAAATTCCT CTCCAAATCT AGCCCCTTGA CTTCGGATTT CACGATTTCT CCCTTCCTCC

1141 TAGAAACTTG ATAAGTTTCC CGCGCTTCCC TTTTTCTAAG ACTACATGTT TGTCATCTTA

1201 TAAAGCAAAG GGGTGAATAA ATGAACCAAA TCAATAACTT CTGGAATATC TGCAAACAAC

1261 AATAATATCA GCTATGCCAT CTTTCACTAT TTTAGCCAGT ATCGAGTTGA ATGAACATAG

1321 AAAAATACAA AACTGAATTC TTCCCTGTAA ATTCCCCGTT TTGACGACGC ACTTGTAGCC

1381 ACGTAGCCAC GCCTACTTAA GACAATTACA AAAGGCGAAG AAGACTGACT CAGGCTTAAG

1441 CTGCCAGCCA GAGAGGGAGT CATTTCATTG GCGTTTGAGT CAGCAAAGGT ATTGTCCTCA

1501 CATCTCTGGC TATTAAAGTA TTTTCTGTTG TTGTTTTTCT CTTTGGCTGT TTTCTCTCAC

1561 ATTGCCTTCT CTAAAGCTAC AGTCTCTCCT TTCTTTTCTT GTCCCTCCCT GGTTTGGTAT

1621 GTGACCTAGA ATTACAGTCA GATTTCAGAA AATGATTCTC TCATTTTGCT GATAAGGACT

1681 GATTCGTTTT ACTGAGGGAC GGCAGAACTA GTTTCCTATG AGGGCATGGG TGAATACAAC

1741 TGAGGCTTCT CATGGGAGGG AATCTCTACT ATCCAAAATT ATTAGGAGAA AATTGAAAAT

1801 TTCCAACTCT CTCTCTCTCT TACCTCTGTG TAAGGCAAAT ACCTTATTCT TGTGGTGTTT EPI-109 670

1861 TTGTAACCTC TTCAAACTTT CATTGATTGA ATGCCTGTTC TGGCAATACA TTAGGTTGGG 1921 CACATAAGGA ATACCAACAT AAATAAAACA TTCTAAAAGA AGTTTACGAT CTAATAAAGG 1981 AGACAGGTAC ATAGCAAACT AATTCAAAGG AGCTAGAAGA TGGAGAAAAT GCTGAATGTG 2041 GACTAAGTCA TTCAACAAAG TTTTCAGGAA GCACAAAGAG GAGGGGCTCC CCTCACAGAT 2101 ATCTGGATTA GAGGCTGGCT GAGCTGATGG TGGCTGGTGT TCTCTGTTGC AGAAGTCAAG 2161 ATGGCCAAAG TTCCAGACAT GTTTGAAGAC CTGAAGAACT GTTACAGGTA AGGAATAAGA 2221 TTTATCTCTT GTGATTTAAT GAGGGTTTCA AGGCTCACCA GAATCCAGCT AGGCATAACA 2281 GTGGCCAGCA TGGGGGCAGG CCGGCAGAGG TTGTAGAGAT GTGTACTAGT CCTGAAGTCA 2341 GAGCAGGTTC AGAGAAGACC CAGAAAAACT AAGCATTCAG CATGTTAAAC TGAGATTACA 2401 TTGGCAGGGA GACCGCCATT TTAGAAAAAT TATTTTTGAG GTCTGCTGAG CCCTACATGA 2461 ATATCAGCAT CAACTTAGAC ACAGCCTCTG TTGAGATCAC ATGCCCTGAT ATAAGAATGG 2521 GTTTTACTGG TCCATTCTCA GGAAAACTTG ATCTCATTCA GGAACAGGAA ATGGCTCCAC 2581 AGCAAGCTGG GCATGTGAAC TCACATATGC AGGCAAATCT CACTCAGATG TAGAAGAAAG 2641 GTAAATGAAC ACAAAGATAA AATTACGGAA CATATTAAAC TAACATGATG TTTCCATTAT 2701 CTGTAGTAAA TACTAACACA AACTAGGCTG TCAAAATTTT GCCTGGATAT TTTACTAAGT 2761 ATAAATTATG AAATCTGTTT TAGTGAATAC ATGAAAGTAA TGTGTAACAT ATAATCTATT 2821 TGGTTAAAAT AAAAAGGAAG TGCTTCAAAA CCTTTCTTTT CTCTAAAGGA GCTTAACATT 2881 CTTCCCTGAA CTTCAATTAA AGCTCTTCAA TTTGTTAGCC AAGTCCAATT TTTACAGATA 2941 AAGCACAGGT AAAGCTCAAA GCCTGTCTTG ATGACTACTA ATTCCAGATT AGTAAGATAT 3001 GAATTACTCT ACCTATGTGT ATGTGTAGAA GTCCTTAAAT TTCAAAGATG ACAGTAATGG 3061 CCATGTGTAT GTGTGTGACC CACAACTATC ATGGTCATTA AAGTACATTG GCCAGAGACC 3121 ACATGAAATA ACAACAATTA CATTCTCATC ATCTTATTTT GACAGTGAAA ATGAAGAAGA 3181 CAGTTCCTCC ATTGATCATC TGTCTCTGAA TCAGGTAAGC AAATGACTGT AATTCTCATG 3241 GGACTGCTAT TCTTACACAG TGGTTTCTTC ATCCAAAGAG AACAGCAATG ACTTGAATCT 3301 TAAATACTTT TGTTTTACCC TCACTAGAGA TCCAGAGACC TGTCTTTCAT TATAAGTGAG 3361 ACCAGCTGCC TCTCTAAACT AATAGTTGAT GTGCATTGGC TTCTCCCAGA ACAGAGCAGA 3421 ACTATCCCAA ATCCCTGAGA ACTGGAGTCT CCTGGGGCAG GCTTCATCAG GATGTTAGTT 3481 ATGCCATCCT GAGAAAGCCC CGCAGGCCGC TTCACCAGGT GTCTGTCTCC TAACGTGATG 3541 TGTTGTGGTT GTCTTCTCTG ACACCAGCAT CAGAGGTTAG AGAAAGTCTC CAAACATGAA 3601 GCTGAGAGAG AGGAAGCAAG CCAGCTGAAA GTGAGAAGTC TACAGCCACT CATCAATCTG 3661 TGTTATTGTG TTTGGAGACC ACAAATAGAC ACTATAAGTA CTGCCTAGTA TGTCTTCAGT 3721 ACTGGCTTTA AAAGCTGTCC CCAAAGGAGT ATTTCTAAAA TATTTTGAGC ATTGTTAAGC 3781 AGATTTTTAA CCTCCTGAGA GGGAACTAAT TGGAAAGCTA CCACTCACTA CAATCATTGT 3841 TAACCTATTT AGTTACAACA TCTCATTTTT GAGCATGCAA ATAAATGAAA AAGTCTTCCT 3901 AAAAAAATCA TCTTTTTATC CTGGAAGGAG GAAGGAAGGT GAGACAAAAG GGAGAGAGGG 3961 AGGGAAGCCT AATGAAACAC CAGTTACCTA AGACCAGAAT GGAGATCCTC CTCACTACCT 4021 CTGTTGAATA CAGCACCTAC TGAAAGAACT TTCATTCCCT GACCATGAAC AGCCTCTCAG 4081 CTTCTGTTTT CCTTCCTCAC AGAAATCCTT CTATCATGTA AGCTATGGCC CACTCCATGA 4141 AGGCTGCATG GATCAATCTG TGTCTCTGAG TATCTCTGAA ACCTCTAAAA CATCCAAGCT 4201 TACCTTCAAG GAGAGCATGG TGGTAGTAGC AACCAACGGG AAGGTTCTGA AGAAGAGACG 4261 GTTGAGTTTA AGCCAATCCA TCACTGATGA TGACCTGGAG GCCATCGCCA ATGACTCAGA 4321 GGAAGGTAAG GGGTCAAGCA CAATAATATC TTTCTTTTAC AGTTTTAAGC AAGTAGGGAC 4381 AGTAGAATTT AGGGGAAAAT TAAACGTGGA GTCAGAATAA CAAGAAGACA ACCAAGCATT 4441 AGTCTGGTAA CTATACAGAG GAAAATTAAT TTTTATCCTT CTCCAGGAGG GAGAAATGAG 4501 CAGTGGCCTG AATCGAGAAT ACTTGCTCAC AGCCATTATT TCTTAGCCAT ATTGTAAAGG 4561 TCGTGTGACT TTTAGCCTTT CAGGAGAAAG CAGTAATAAG ACCACTTACG AGCTATGTTC 4621 CTCTCATACT AACTATGCCT CCTTGGTCAT GTTACATAAT CTTTTCGTGA TTCAGTTTCC 4681 TCTACTGTAA AATGGAGATA ATCAGAATCC CCCACTCATT GGATTGTTGT AAAGATTAAG 4741 AGTCTCAGGC TTTACAGACT GAGCTAGCTG GGCCCTCCTG ACTGTTATAA AGATTAAATG 4801 AGTCAACATC CCCTAACTTC TGGACTAGAA TAATGTCTGG TACAAAGTAA GCACCCAATA 4861 AATGTTAGCT ATTACTATCA TTATTATTAT TATTTTATTT TTTTTTTTTG AGATGGAGTC 4921 TGGCTCTGTC ACCCAGGCTG GAGTGCAGTG GCACAATCTC GGCTCACTGC AAGCTCTGCC 4981 TCCTGGGTTC ATGCCATTCT CCTGCCTCAG CCTCCCGAGT AAGCTGGGAA TACAGGCACC 5041 CGCCACTGTT CCCGGCTAAT TTTTTGTATT TTTAGTAGAG ACGGAGTTTC ACCGTGGTCT 5101 CCATCTCCTC GTGATCCACC CACCTTGGCC TCCCAAAGTG CCGGGATTAC AGGCGTGAGC 5161 CACCGCGCCC GGCCTATTAT TATTATTATT ACTACTACTA CTACCTATAT GAATACTACC 5221 AGCAATACTA ATTTATTAAT GACTGGATTA TGTCTAAACC TCACAAGAAT CCTACCTTCT 5281 CATTTTACAT AAAAGGAAAC TAAGCTCATT GAGATAGGTA AACTGCCCAA TGGCATACAT 5341 CTGTAAGTGG GAGAGCCTCA AATCTAATTC AGTTCTACCT GAGTAAAAAA ATCATGGTTT 5401 CTCCTCCATC CCTTTACTGT ACAAGCCTCC ACATGAACTA TAAACCCAAT ATTCCTGTTT 5461 TTAAGATAAT ACCTAAGCAA TAACGCATGT TCACCTAGAA GGTTTTAAAA TGTAACAAAA 5521 TATAAGAAAA TAAAAATCAC TCATATCGTC AGTGAGAGTT TACTACTGCC AGCACTATGG 5581 TATGTTTCCT TAAAATCTTT GCTATACACA TACCTACATG TGAACAAATA TGTCTAACAT 5641 CAAGACCACA CTATTTACAA CTTTATATCC AGCTTTTCTT ACTTAGCAAT GTATTGAGGA 5701 CATTTTAGAG TGCCCGTTT.T TCACCATTAT AAGCAATGCA ACAATGAACA TCTGTATAAA 5761 TAAATATTCA TTTCTCTCAC CCTTTATTTC CTTAGAATAT ATTCCTAGAA GTAGAATTTC 5821 CCAGAGCCAT GAGGATTTGT GACGCTATTG ATATGTGCCA CTTTGCACTC TCTGTGACAT 5881 ATATAATTAT TTTTAATGCA TTCATTTTTT TCTCAGAGTG CATTCGTTTG AAAACATAGA EPI-109 671

5941 CGGGAAATAC TGGTAGTCTT CCTTGTCAGT TAGAAACACC CAAACAATGA AAAATGAAAA 6001 AGTTGCACAA ATAGTCTCTA AAAACAATGA AACTATTGCC TGAGGAATTG AAGTTTAAAA 6061 AGAAGCACAT AAGCAACAAC AAGGATAATC CTAGAAAACC AGTTCTGCTG ACTGGGTGAT 6121 TTCACTTCTC TTTGCTTCCT CATCTGGATT GGAATATTCC TAATACCCCC TCCAGAACTA 6181 TTTTCCCTGT TTGTACTAGA CTGTGTATAT CATCTGTGTT TGTACATAGA CATTAATCTG 6241 CACTTGTGAT CATGGTTTTA GAAATCATCA AGCCTAGGTC ATCACCTTTT AGCTTCCTGA 6301 GCAATGTGAA ATACAACTTT ATGAGGATCA TCAAATACGA ATTCATCCTG AATGACGCCC 6361 TCAATCAAAG TATAATTCGA GCCAATGATC AGTACCTCAC GGCTGCTGCA TTACATAATC 6421 TGGATGAAGC AGGTACATTA AAATGGCACC AGACATTTCT GTCATCCTCC CCTCCTTTCA 6481 TTTACTTATT TATTTATTTC AATCTTTCTG CTTGCAAAAA ACATACCTCT TCAGAGTTCT 6541 GGGTTGCACA ATTCTTCCAG AATAGCTTGA AGCACAGCAC CCCCATAAAA ATCCCAAGCC 6601 AGGGCAGAAG GTTCAACTAA ATCTGGAAGT TCCACAAGAG AGAAGTTTCC TATCTTTGAG 6661 AGTAAAGGGT TGTGCACAAA GCTAGCTGAT GTACTACCTC TTTGGTTCTT TCAGACATTC 6721 TTACCCTCAA TTTTAAAACT GAGGAAACTG TCAGACATAT TAAATGATTT ACTCAGATTT 6781 ACCCAGAAGC CAATGAAGAA CAATCACTCT CCTTTAAAAA GTCTGTTGAT CAAACTCACA 6841 AGTAACACCA AACCAGGAAG ATCTTTATTA TCTCTGATAA CATATTTGTG AGGCAAAACC 6901 TCCAATAAGC TACAAATATG GCTTAAAGGA TGAAGTTTAG TGTCCAAAAA CTTTTATCAC 6961 ACACATCCAA TTTTCATGGC GGACATGTTT TAGTTTCAAC AGTATACATA TTTTCAAAGG 7021 TCCAGAGAGG CAATTTTGCA ATAAACAAGC AAGACTTTTT CTGATTGGAT GCACTTCAGC 7081 TAACATGCTT TCAACTCTAC ATTTACAAAT TATTTTGTGT TCTATTTTTC TACTTAATAT 7141 TATTTCTGCA ATTTTCCCAA TATTGACATC GTGTATGTAT TTGCCATTTT TAATATCACT 7201 AGACAATTCA ATCAGGTTGC TACGTTGGTC CCTTGGGTTT ACTCTAAATA GCTTGATTGC 7261 AAATATCTTT GTATATATTA TTGTTTTTTC TCCTATCTTG TAATTTCTTT GAGCACATCC 7321 CAAAGAGGAA TGCCTAGATC AATGGGCACA AATAATTTGA CAGCTCTTAT TAAACATTAT 7381 TCTGTAAGTA AAAACTGAAC TACTTTTCAG TATCACTAGC AACATATGAG TGTATCAGCT 7441 TCCTAAACCC CTCCATGTTA GGTCATTATG AACTTATGAT CTAACAAATT ACAGGGTCTT 7501 ATCCCACTAA TGAAATTATA AGAGATTCAA CACTTATTCA GCCCCGAAGG ATTCATTCAA 7561 CGTAGAAAAT TCTAAGAACA TTAACCAAGT ATTTACCTGC CTAGTGAGTG TGGAAGACAT 7621 TGTGAAGGAC ACAAAGATGT ATAGAATTCC ATTCCTGACT TCCAGGTATT TACACCATAG 7681 GTGGGGACCT AACTACACAC ACACACACAC ACACACACAC ACACACACAC ACCATGCACA 7741 CACAATCTAC ATCAACACTT GATTTTATAC AAATACAATG AATTTACTTT CTTTTTGGTT 7801 CTTCTCTTCA CCAGTGAAAT TTGACATGGG TGCTTATAAG TCATCAAAGG ATGATGCTAA 7861 AATTACCGTG ATTCTAAGAA TCTCAAAAAC TCAATTGTAT GTGACTGCCC AAGATGAAGA 7921 CCAACCAGTG CTGCTGAAGG TCAGTTGTCC TTTGTCTCCA ACTTACCTTC ATTTACATCT 7981 CATATGTTTG TAAATAAGCC CAATAGGCAG ACACCTCTAA CAAGGTGACA CTGTCCTCTT 8041 TCCTTCCTAC CACAGCCCCC ACCTACCCAC CCCACTCCCA TTGATTCCAG AGGCGTGCCT 8101 AGGCAGGATC TATGAGAAAA TATAACAGAG AGTAAGAGGA AAATTACCTT CTTTCTTTTT 8161 CCTTTCCCTG CCTGACCTTA TTCACCTCCC ATCCCAGAGC ATCCATTTAT TCCATTGATC 8221 TTTACTGACA TCTATTATCT GACCTACACA ATACTAGACA TTAGGACAAT GTGGCCTGCC 8281 TCCAAGAAAC TCAAATAAGC CAACTGAGAT CAGAGAGGAT TAATCACCTG CCAATGGGCA 8341 CAAAGCAACA AGCTGGGAGC CAAGTCCCAA AATGGGGCCT GCTGCTTCCA GTTCCCCTCT 8401 CTCTGCATTG ATGTCAGCAT TATCCTTCGT CCCAGTCCTG TCTCCACTAC CACTTTCCCC 8461 CTCAAACACA CACACACACA ACAGCCTTAG ATGTTTTCTC CACTGATAAG TAGGTGACTC 8521 AATTTGTAAG TATATAATCC AAGACCTTCT ATTCCCAAGT AGAATTTATG TGCCTGCCTG 8581 TGCTTTTCTA CCTGGATCAA GTGATGTCTA CAGAGTAGGG CAGTAGCTTC ATTCATGAAC 8641 TCATTCAACA AGCATTATTC ACTGAGAGCC TTGTATTTTT CAGGCATAGT GCCAACAGCA 8701 GTGTGGACAG TGGTGCATCA AAGCCTCTAG TCTCATAGAA CTTAGTCTTC TGGAGGATAT 8761 GGAAAACAGA CAACCCAAAC AACCAACAAA AGAGCAAGAT GCTGCAAAAA AAAAAAAAAT 8821 GAATAGGGTG CTAAGATAGA GAAAAGTGGG AGAGTGCTAT TTAGACAAAG TGGTAAAAAC 8881 AAAGCCCCTT GTGAGATGAG AGCTGCCGAC AGAGGGGGCG GGTCATGGTT GTGGGTTTTT 8941 GGGTAGGACA TTCAGAGGAG GGGGCGGGTC GTGGTTGTGG GTTTTTGGGT AGGACATTCA 9001 GAGGAGGGGG CGGGTCGTGG TTGTGGGTTT TTGGGTAGGA CATTCAGAGG AGGGGGCGGG 9061 TCGTGGTTGT GGGTTTTTGG GTAGGACATT CAGAGGAGGG GGCGGGTCGT GGTTGTGGGT 9121 TTTTGGGACA TTCAGAGGAG TCTGAATGCA CCCAGGCCTA CAACTTCAAG ATGGTAAAGG 9181 ACAGCTCCAA GGATCAGAAG AAGCATTCTT GGAACTGGGG CATTTTGAGA AGGAGGAAAA 9241 ATATGCAGAG ACTAGTGCTT GCAGAGCTTG CATTTGGATT TCATTTGAGG TACAATGAAA 9301 ACCCATTAAT GGGTTTCACA CAGTGCAATG GCCTGACCTC ACTTATATTT CCTAAAATAG 9361 AAAACAGATC AGAAGGAAGG CAATAGAGAA GCAGAAAGTC CAATGAGGAG GTTTCACAGC 9421 AGTCATGGGG GTGGGGTAAG GAAAAGAAGT GGAAAGAAAC AGACAGAATT GGGTTATATT 9481 TTGGAGATAG AACCAACAGA AGGAAGAGGA GAAACAACAT TTACTGAGAA GGGAAAAAGT 9541 AGGAGAGGAA TAGGTTTGGG AAATAAATCC TGCTGACATT GGAAACCCCA AGGAAGCCTC 9601 AAAAGTATAT TTACTTGCTT TAGATTTAAA AGAATAGGAA AGAAGCATCT CAACTTGGAA 9661 TTTGAAATCT ATTTTTCCAT AAAAGTATTG TTAAATTCTA CTCATACTCA CAAGAAAAGT 9721 ACATTCTAAA GAGTATATTG AAAGAGTTTA CTGATATACT TAGGAATTTT GTGTGTATGT 9781 GTGTGTGTGT ATGTGTGTGT GTGTGTTTAA CCTTCAATTG TTGACTTAAA TACTGAGATA 9841 AATGTCATCT AAATGCTAAA TTGATTTCCC AAAGGTATGA TTTGTTCACT TGGAGATCAA 9901 AATGTTTAGG GGGCTTAGAA TCACTGTAGT GCTCAGATTT GATGCAAAAT GTCTTAGGCC 9961 TATGTTGAAG GCAGGACAGA AACAATGTTT CCCTCCTACC TGCCTGGATA CAGTAAGATA EPI-109 672

10021 CTAGTGTCAC TGACAATCTT CATAACTAAT TTAGATCTCT CTCCAATCAA CTAAGGAAAT 10081 CAACTCTTAT TAATAGACTG GGCCACACAT CTACTAGGCA TGTAATAAAT GCTTGCTGAA 10141 TGAACAAATG AATGAAGAGC CTATAGCATC ATGTTACAGC CATAGTCCTA AAGTGGTGTT 10201 TCTCATGAAG GCCAAATGCT AAGGGATTGA GCTTCAGTCC TTTTTCTAAC ATCTTGTTCT 10261 CTAACAGAAT TCTCTTCTTT TCTTCATAGG AGATGCCTGA GATACCCAAA ACCATCACAG 10321 GTAGTGAGAC CAACCTCCTC TTCTTCTGGG AAACTCACGG CACTAAGAAC TATTTCACAT 10381 CAGTTGCCCA TCCAAACTTG TTTATTGCCA CAAAGCAAGA CTACTGGGTG TGCTTGGCAG 10441 GGGGGCCACC CTCTATCACT GACTTTCAGA TACTGGAAAA CCAGGCGTAG GTCTGGAGTC 10501 TCACTTGTCT CACTTGTGCA GTGTTGACAG TTCATATGTA CCATGTACAT GAAGAAGCTA 10561 AATCCTTTAC TGTTAGTCAT TTGCTGAGCA TGTACTGAGC CTTGTAATTC TAAATGAATG 10621 TTTACACTCT TTGTAAGAGT GGAACCAACA CTAACATATA ATGTTGTTAT TTAAAGAACA 10681 CCCTATATTT TGCATAGTAC CAATCATTTT AATTATTATT CTTCATAACA ATTTTAGGAG 10741 GACCAGAGCT ACTGACTATG GCTACCAAAA AGACTCTACC CATATTACAG ATGGGCAAAT 10801 TAAGGCATAA GAAAACTAAG AAATATGCAC AATAGCAGTT GAAACAAGAA GCCACAGACC 10861 TAGGATTTCA TGATTTCATT TCAACTGTTT GCCTTCTGCT TTTAAGTTGC TGATGAACTC 10921 TTAATCAAAT AGCATAAGTT TCTGGGACCT CAGTTTTATC ATTTTCAAAA TGGAGGGAAT 10981 AATACCTAAG CCTTCCTGCC GCAACAGTTT TTTATGCTAA TCAGGGAGGT CATTTTGGTA 11041 AAATACTTCT CGAAGCCGAG CCTCAAGATG AAGGCAAAGC ACGAAATGTT ATTTTTTAAT 11101 TATTATTTAT ATATGTATTT ATAAATATAT TTAAGATAAT TATAATATAC TATATTTATG 11161 GGAACCCCTT CATCCTCTGA GTGTGACCAG GCATCCTCCA CAATAGCAGA CAGTGTTTTC 11221 TGGGATAAGT AAGTTTGATT TCATTAATAC AGGGCATTTT GGTCCAAGTT GTGCTTATCC 11281 CATAGCCAGG AAACTCTGCA TTCTAGTACT TGGGAGACCT GTAATCATAT AATAAATGTA 11341 CATTAATTAC CTTGAGCCAG TAATTGGTCC GATCTTTGAC TCTTTTGCCA TTAAACTTAC 11401 CTGGGCATTC TTGTTTCATT CAATTCCACC TGCAATCAAG TCCTACAAGC TAAAATTAGA 11461 TGAACTCAAC TTTGACAACC ATGAGACCAC TGTTATCAAA ACTTTCTTTT CTGGAATGTA 11521 ATCAATGTTT CTTCTAGGTT CTAAAAATTG TGATCAGACC ATAATGTTAC ATTATTATCA 11581 ACAATAGTGA TTGATAGAGT GTTATCAGTC ATAACTAAAT AAAGCTTGCA ACAAAATTCT 11641 CTGACACATA GTTATTCATT GCCTTAATCA TTATTTTACT GCATGGTAAT TAGGGACAAA 11701 TGGTAAATGT TTACATAAAT AATTGTATTT AGTGTTACTT TATAAAATCA AACCAAGATT 11761 TTATATTTTT TTCTCCTCTT TGTTAGCTGC CAGTATGCAT AAATGGCATT AAGAATGATA 11821 ATATTTCCGG GTTCACTTAA AGCTCATATT ACACATACAC AAAACATGTG TTCCCATCTT 11881 TATACAAACT CACACATACA GAGCTACATT AAAAACAACT AATAGGCCAG GCACGGTGGC 11941 TCAGACCTGT AATCCCAGCA CTTTGGGAGG

(2) INFORMATION FOR SEQ ID NO: 2511: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1497 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2511:

1 ACCAACCTCT TCGAGGCACA AGGCACAACA GGCTGCTCTG GGATTCTCTT CAGCCAATCT

61 TCATTGCTCA AGTGTCTGAA GCAGCCATGG CAGAAGTACC TGAGCTCGCC AGTGAAATGA

121 TGGCTTATTA CAGTGGCAAT GAGGATGACT TGTTCTTTGA AGCTGATGGC CCTAAACAGA

181 TGAAGTGCTC CTTCCAGGAC CTGGACCTCT GCCCTCTGGA TGGCGGCATC CAGCTACGAA

241 TCTCCGACCA CCACTACAGC AAGGGCTTCA GGCAGGCCGC GTCAGTTGTT GTGGCCATGG

301 ACAAGCTGAG GAAGATGCTG GTTCCCTGCC CACAGACCTT CCAGGAGAAT GACCTGAGCA

361 CCTTCTTTCC CTTCATCTTT GAAGAAGAAC CTATCTTCTT CGACACATGG GATAACGAGG

421 CTTATGTGCA CGATGCACCT GTACGATCAC TGAACTGCAC GCTCCGGGAC TCACAGCAAA

481 AAAGCTTGGT GATGTCTGGT CCATATGAAC TGAAAGCTCT CCACCTCCAG GGACAGGATA

541 TGGAGCAACA AGTGGTGTTC TCCATGTCCT TTGTACAAGG AGAAGAAAGT AATGACAAAA

601 TACCTGTGGC CTTGGGCCTC AAGGAAAAGA ATCTGTACCT GTCCTGCGTG TTGAAAGATG

661 ATAAGCCCAC TCTACAGCTG GAGAGTGTAG ATCCCAAAAA TTACCCAAAG AAGAAGATGG

721 AAAAGCGATT TGTCTTCAAC AAGATAGAAA TCAATAACAA GCTGGAATTT GAGTCTGCCC

781 AGTTCCCCAA CTGGTACATC AGCACCTCTC AAGCAGAAAA CATGCCCGTC TTCCTGGGAG

841 GGACCAAAGG CGGCCAGGAT ATAACTGACT TCACCATGCA ATTTGTGTCT TCCTAAAGAG

901 AGCTGTACCC AGAGAGTCCT GTGCTGAATG TGGACTCAAT CCCTAGGGCT GGCAGAAAGG

961 GAACAGAAAG GTTTTTGAGT ACGGCTATAG CCTGGACTTT CCTGTTGTCT ACACCAATGC

1021 CCAACTGCCT GCCTTAGGGT AGTGCTAAGA GGATCTCCTG TCCATCAGCC AGGACAGTCA

1081 GCTCTCTCCT TTCAGGGCCA ATCCCCAGCC CTTTTGTTGA GCCAGGCCTC TCTCACCTCT

1141 CCTACTCACT TAAAGCCCGC CTGACAGAAA CCACGGCCAC ATTTGGTTCT AAGAAACCCT

1201 CTGTCATTCG CTCCCACATT CTGATGAGCA ACCGCTTCCC TATTTATTTA TTTATTTGTT

1261 TGTTTGTTTT ATTCATTGGT CTAATTTATT CAAAGGGGGC AAGAAGTAGC AGTGTCTGTA

1321 AAAGAGCCTA GTTTTTAATA GCTATGGAAT CAATTCAATT TGGACTGGTG TGCTCTCTTT

1381 AAATCAAGTC CTTTAATTAA GACTGAAAAT ATATAAGCTC AGATTATTTA AATGGGAATA

1441 TTTATAAATG AGCAAATATC ATACTGTTCA ATGGTTCTGA AATAAACTTC TCTGAAG

(2) INFORMATION FOR SEQ ID NO: 2512: (i) SEQUENCE CHARACTERISTICS: EPI-109 673

(A) LENGTH : 9721 base pairs

( B ) TYPE : nucleic acid

( C) STRANDEDNESS : single

( D ) TOPOLOGY : linear

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 2512 :

1 AGAAAGAAAG AGAGAGAGAA AGAAAAGAAA GAGGAAGGAA GGAAGGAAGG AAGAAAGACA

61 GGCTCTGAGG AAGGTGGCAG TTCCTACAAC GGGAGAACCA GTGGTTAATT TGCAAAGTGG

121 ATCCTGTGGA GGCANNCAGA GGAGTCCCCT AGGCCACCCA GACAGGGCTT TTAGCTATCT

181 GCAGGCCAGA CACCAAATTT CAGGAGGGCT CAGTGTTAGG AATGGATTAT GGCTTATCAA

241 ATTCACAGGA AACTAACATG TTGAACAGCT TTTAGATTTC CTGTGGAAAA TATAACTTAC

301 TAAAGATGGA GTTCTTGTGA CTGACTCCTG ATATCAAGAT ACTGGGAGCC AAATTAAAAA

361 TCAGAAGGCT GCTTGGAGAG CAAGTCCATG AAATGCTCTT TTTCCCACAG TAGAACCTAT

421 TTCCCTCGTG TCTCAAATAC TTGCACAGAG GCTCACTCCC TTGGATAATG CAGAGCGAGC

481 ACGATACCTG GCACATACTA ATTTGAATAA AATGCTGTCA AATTCCCATT CACCCATTCA

541 AGCAGCAAAC TCTATCTCAC CTGAATGTAC ATGCCAGGCA CTGTGCTAGA CTTGGCTCAA

601 AAAGATTTCA GTTTCCTGGA GGAACCAGGA GGGCAAGGTT TCAACTCAGT GCTATAAGAA

661 GTGTTACAGG CTGGACACGG TGGCTCACGC CTGTAATCCC AACATTTGGG AGGCCGAGGC

721 GGGCAGATCA CAAGGTCAGG AGATCGAGAC CATCCTGGCT AACATGGTGA AACCCTGTCT

781 CTACTAAAAA TACAAAAAAT TAGCCGGGCG TTGGCGGCAG GTGCCTGTAG TCCCAGCTGC

841 TGGGGAGGCT GAGGCAGGAG AATGGTGTGA ACCCGGGAGG CGGAACTTGC AGGGGGCCGA

901 GATCGTGCCA CTGCACTCCA GCCTGGGCGA CAGAGTGAGA CTCTGTCTCA AAAAAAAAAA

961 AAAAGTGTTA TGATGCAGAC CTGTCAAAGA GGCAAAGGAG GGTGTTCCTA CACTCCAGGC

1021 ACTGTTCATA ACCTGGACTC TCATTCATTC TACAAATGGA GGGCTCCCCT GGGCAGATCC

1081 CTGGAGCAGG CACTTTGCTG GTGTCTCGGT TAAAGAGAAA CTGATAACTC TTGGTATTAC

1141 CAAGAGATAG AGTCTCAGAT GGATATTCTT ACAGAAACAA TATTCCCACT TTTCAGAGTT

1201 CACCAAAAAA TCATTTTAGG CAGAGCTCAT CTGGCATTGA TCTGGTTCAT CCATGAGATT

1261 GGCTAGGGTA ACAGCACCTG GTCTTGCAGG GTTGTGTGAG CTTATCTCCA GGGTTGCCCC

1321 AACTCCGTCA GGAGCCTGAA CCCTGCATAC CGTATGTTCT CTGCCCCAGC CAAGAAAGGT

1381 CAATTTTCTC CTCAGAGGCT CCTGCAATTG ACAGAGAGCT CCCGAGGCAG AGAACAGCAC

1441 CCAAGGTAGA GACCCACACC CTCAATACAG ACAGGGAGGG CTATTGGCCC TTCATTGTAC

1501 CCATTTATCC ATCTGTAAGT GGGAAGATTC CTAAACTTAA GTACAAAGAA GTGAATGAAG

1561 AAAAGTATGT GCATGTATAA ATCTGTGTGT CTTCCACTTT GTCCCACATA TACTAAATTT

1621 AAACATTCTT CTAACGTGGG AAAATCCAGT ATTTTAATGT GGACATCAAC TGCACAACGA

1681 TTGTCAGGAA AACAATGCAT ATTTGCATGG TGATACATTT GCAAAATGTG TCATAGTTTG

1741 CTACTCCTTG CCCTTCCATG AACCAGAGAA TTATCTCAGT TTATTAGTCC CCTCCCCTAA

1801 GAAGCTTCCA CCAATACTCT TTTCCCCTTT CCTTTAACTT GATTGTGAAA TCAGGTATTC

1861 AACAGAGAAA TTTCTCAGCC TCCTACTTCT GCTTTTGAAA GCTATAAAAA CAGCGAGGGA

1921 GAAACTGGCA GATACCAAAC CTCTTCGAGG CACAAGGCAC AACAGGCTGC TCTGGGATTC

1981 TCTTCAGCCA ATCTTCATTG CTCAAGTATG ACTTTAATCT TCCTTACAAC TAGGTGCTAA

2041 GGGAGTCTCT CTGTCTCTCT GCCTCTTTGT GTGTATGCAT ATTCTCTCTC TCTCTCTCTT

2101 TCTTTCTCTG TCTCTCCTCT CCTTCCTCTC TGCCTCCTCT CTCAGCTTTT TGCAAAAATG

2161 CCAGGTGTAA TATAATGCTT ATGACTCGGG AAATATTCTG GGAATGGATA CTGCTTATCT

2221 AACAGCTGAC ACCCTAAAGG TTAGTGTCAA AGCCTCTGCT CCAGCTCTCC TAGCCAATAC

2281 ATTGCTAGTT GGGGTTTGGT TTAGCAAATG CTTTTCTCTA GACCCAZ^AGG ACTTCTCTTT

2341 CACACATTCA TTCATTTACT CAGAGATCAT TTCTTTGCAT GACTGCCATG CACTGGATGC

2401 TGAGAGAAAT CACACATGAA CGTAGCCGTC ATGGGGAAGT CACTCATTTT CTCCTTTTTA

2461 CACAGGTGTC TGAAGCAGCC ATGGCAGAAG TACCTGAGCT CGCCAGTGAA ATGATGGCTT

2521 ATTACAGGTC AGTGGAGACG CTGAGACCAG TAACATGAGC AGGTCTCCTC TTTCAAGAGT

2581 AGAGTGTTAT CTGTGCTTGG AGACCAGATT TTTCCCCTAA ATTGCCTCTT TCAGTGGCAA

2641 ACAGGGTGCC AAGTAAATCT GATTTAAAGA CTACTTTCCC ATTACAAGTC CCTCCAGCCT

2701 TGGGACCTGG AGGCTATCCA GATGTGTTGT TGCAAGGGCT TCCTGCAGAG GCAAATGGGG

2761 AGAAAAGATT CCAAGCCCAC AATACAAGGA ATCCCTTTGC AAAGTGTGGC TTGGAGGGAG

2821 AGGGAGAGCT CAGATTTTAG CTGACTCTGC TGGGCTAGAG GTTAGGCCTC AAGATCCAAC

2881 AGGGAGCACC AGGGTGCCCA CCTGCCAGGC CTAGAATCTG CCTTCTGGAC TGTTCTGCGC

2941 ATATCACTGT GAAACTTGCC AGGTGTTTCA GGCAGCTTTG AGAGGCAGGC TGTTTGCAGT

3001 TTCTTATGAA CAGTCAAGTC TTGTACACAG GGAAGGAAAA ATAAACCTGT TTAGAAGACA

3061 TAATTGAGAC ATGTCCCTGT TTTTATTACA GTGGCAATGA GGATGACTTG TTCTTTGAAG

3121 CTGATGGCCC TAAACAGATG AAGGTAAGAC TATGGGTTTA ACTCCCAACC CAAGGAAGGG

3181 CTCTAACACA GGGAAAGCTC AAAGAAGGGA GTTCTGGGCC ACTTTGATGC CATGGTATTT

3241 TGTTTTAGAA AGACTTTAAC CTCTTCCAGT GAGACACAGG CTGCACCACT TGCTGACCTG

3301 GCCACTTGGT CATCATATCA CCACAGTCAC TCACTAACGT TGGTGGTGGT GGCCACACTT

3361 GGTGGTGACA GGGGAGGAGT AGTGATAATG TTCCCATTTC ATAGTAGGAA GACAACCAAG

3421 TCTTCAACAT AAATTTGATT ATCCTTTTAA GAGATGGATT CAGCCTATGC CAATCACTTG

3481 AGTTAAACTC TGAAACCAA^'G AGATGATCTT GAGAACTAAC ATATGTCTAC CCCTTTTGAG

3541 TAGAATAGTT TTTTGCTACC TGGGGTGAAG CTTATAACAA CAAGACATAG ATGATATAAA

3601 CAAAAAGATG AATTGAGACT TGAAAGAAAA CCATTCACTT GCTGTTTGAC CTTGACAAGT

3661 CATTTTACCC GCTTTGGACC TCATCTGAAA AATAAAGGGC TGAGCTGGAT GATCTCTGAG

3721 ATTCCAGCAT CCTGCAACCT CCAGTTCTGA AATATTTTCA GTTGTAGCTA AGGGCATTTG

3781 GGCAGCAAAT GGTCATTTTT CAGACTCATC CTTACAAAGA GCCATGTTAT ATTCCTGCTG EPI-109 674

3841 TCCCTTCTGT TTTATATGAT GCTCAGTAGC CTTCCTAGGT GCCCAGC AT CAGCCTAGCT

3901 AGGTCAGTTG TGCAGGTTGG AGGCAGCCAC TTTTCTCTGG CTTTATTTTA TTCCAGTTTG 3961 TGATAGCCTC CCCTAGCCTC ATAATCCAGT CCTCAATCTT GTTAAAAACA TATTTCTTTA

4021 GAAGTTTTAA GACTGGCATA ACTTCTTGGC TGCAGCTGTG GGAGGAGCCC ATTGGCTTGT 4081 CTGCCTGGCC TTTGCCCCCC ATTGCCTCTT CCAGCAGCTT GGCTCTGCTC CAGGCAGGAA 4141 ATTCTCTCCT GCTCAACTTT CTTTTGTGCA CTTACAGGTC TCTTTAACTG TCTTTCAAGC 4201 CTTTGAACCA TTATCAGCCT TAAGGCAACC TCAGTGAAGC CTTAATACGG AGCTTCTCTG 4261 AATAAGAGGA AAGTGGTAAC ATTTCACAAA AAGTACTCTC ACAGGATTTG CAGAATGCCT 4321 ATGAGACAGT GTTATGAAAA AGGAAAAAAA AGAACAGTGT AGAAAAATTG AATACTTGCT 4381 GAGTGAGCAT AGGTGAATGG AAAATGTTAT GGTCATCTGC ATGAAAAAGC AAATCATAGT 4441 GTGACAGCAT TAGGGATACA AAAAGATATA GAGAAGGTAT ACATGTATGG TGTAGGTGGG 4501 GCATGTACAA AAAGATGACA AGTAGAATCG GGATTTATTC TAAAGAATAG CCTGTAAGGT 4561 GTCCAGAAGC CACATTCTAG TCTTGAGTCT GCCTCTACCT GCTGTGTGCC CTTGAGTACA 4621 CCCTTAACCT CCTTGAGCTT CAGAGAGGGA TAATCTTTTT ATTTTATTTT ATTTTATTTT 4681 GTTTTGTTTT GTTTTGTTTT GTTTTATGAG ACAGAGTCTC ACTCTGTTGC CCAGGCTGGA 4741 GTGCAGTGGT ACAATCTTGG CTTACTGCAT CCTCCACCTC CTGAGTTCAA GCGATTCTCC 4801 TTCCTCAGTC TCCTGAATAG CTAGGATTAC AGGTGCACCC CACCACACCC AGCTAATTTT 4861 TGTATTTTTA GTAGAGAAGG GGTTTCGCCA TGTTGGCCAG GCTGGTTTTG AAGTCCTGAC 4921 CTAAATGATT CATCCACCTC GGCTTCCCAA AGTGCTGGGA TTACAGGCAT GAGCCACCAC 4981 GCCTGGCCCA GAGAGGGATG ATCTTTAGAA GCTCGGGATT CTTTCAAGCC CTTTCCTCCT 5041 CTCTGAGCTT TCTACTCTCT GATGTCAAAG CATGGTTCCT GGCAGGACCA CCTCACCAGG 5101 CTCCCTCCCT CGCTCTCTCC GCAGTGCTCC TTCCAGGACC TGGACCTCTG CCCTCTGGAT 5161 GGCGGCATCC AGCTACGAAT CTCCGACCAC CACTACAGCA AGGGCTTCAG GCAGGCCGCG 5221 TCAGTTGTTG TGGCCATGGA CAAGCTGAGG AAGATGCTGG TTCCCTGCCC ACAGACCTTC 5281 CAGGAGAATG ACCTGAGCAC CTTCTTTCCC TTCATCTTTG AAGAAGGTAG TTAGCCAAGA 5341 GCAGGCAGTA GATCTCCACT TGTGTCCTCT TGGAAGTCAT CAAGCCCCAG CCAACTCAAT 5401 TCCCCCAGAG CCAAAGCCCT TTAAAGGTAG AAGGCCCAGC GGGGAGACAA AACAAAGAAG 5461 GCTGGAAACC AAAGCAATCA TCTCTTTAGT GGAAACTATT CTTAAAGAAG ATCTTGATGG 5521 CTACTGACAT TTGCAACTCC CTCACTCTTT CTCAGGGGCC TTTCACTTAC ATTGTCACCA 5581 GAGGTTCGTA ACCTCCCTGT GGGCTAGTGT TATGACCATC ACCATTTTAC CTAAGTAGCT 5641 CTGTTGCTCG GCCACAGTGA GCAGTAATAG ACCTGAAGCT GGAACCCATG TCTAATAGTG 5701 TCAGGTCCAG TGTTCTTAGC CACCCCACTC CCAGCTTCAT CCCTACTGGT GTTGTCATCA 5761 GACTTTGACC GTATATGCTC AGGTGTCCTC CAAGAAATCA AATTTTGCCA CCTCGCCTCA 5821 CGAGGCCTGC CCTTCTGATT TTATACCTAA ACAACATGTG CTCCACATTT CAGAACCTAT 5881 CTTCTTCGAC ACATGGGATA ACGAGGCTTA TGTGCACGAT GCACCTGTAC GATCACTGAA 5941 CTGCACGCTC CGGGACTCAC AGCAAAAAAG CTTGGTGATG TCTGGTCCAT ATGAACTGAA 6001 AGCTCTCCAC CTCCAGGGAC AGGATATGGA GCAACAAGGT AAATGGAAAC ATCCTGGTTT 6061 CCCTGCCTGG CCTCCTGGCA GCTTGCTAAT TCTCCATGTT TTAAACAAAG TAGAAAGTTA 6121 ATTTAAGGCA AATGATCAAC ACAAGTGAAA AAAAATATTA AAAAGGAATA TACAAACTTT 6181 GGTCCTAGAA ATGGCACATT TGATTGCACT GGCCAGTGCA TTTGTTAACA GGAGTGTGAC 6241 CCTGAGAAAT TAGACGGCTC AAGCACTCCC AGGACCATGT CCACCCAAGT CTCTTGGGCA 6301 TAGTGCAGTG TCAATTCTTC CACAATATGG GGTCATTTGA TGGACATGGC CTAACTGCCT 6361 GTGGGTTCTC TCTTCCTGTT GTTGAGGCTG AAACAAGAGT GCTGGAGCGA TAATGTGTCC 6421 ATCCCCCTCC CCAGTCTTCC CCCCTTGCCC CAACATCCGT CCCACCCAAT GCCAGGTGGT 6481 TCCTTGTAGG GAAATTTTAC CGCCCAGCAG GAACTTATAT CTCTCCGCTG TAACGGGCAA 6541 AAGTTTCAAG TGCGGTGAAC CCATCATTAG CTGTGGTGAT CTGCCTGGCA TCGTGCCACA 6601 GTAGCCAAAG CCTCTGCACA GGAGTGTGGG CAACTAAGGC TGCTGACTTT GAAGGACAGC 6661 CTCACTCAGG GGGAAGCTAT TTGCTCTCAG CCAGGCCAAG AAAATCCTGT TTCTTTGGAA 6721 TCGGGTAGTA AGAGTGATCC CAGGGCCTCC AATTGACACT GCTGTGACTG AGGAAGATCA 6781 AAATGAGTGT CTCTCTTTGG AGCCACTTTC CCAGCTCAGC CTCTCCTCTC CCAGTTTCTT 6841 CCCATGGGCT ACTCTCTGTT CCTGAAACAG TTCTGGTGCC TGATTTCTGG CAGAAGTACA 6901 GCTTCACCTC TTTCCTTTCC TTCCACATTG ATCAAGTTGT TCCGCTCCTG TGGATGGGCA 6961 CATTGCCAGC CAGTGACACA ATGGCTTCCT TCCTTCCTTC CTTCAGCATT TAAAATGTAG 7021 ACCCTCTTTC ATTCTCCGTT CCTACTGCTA TGAGGCTCTG AGAAACCCTC AGGCCTTTGA 7081 GGGGAAACCC TAAATCAACA AAATGACCCT GCTATTGTCT GTGAGAAGTC AAGTTATCCT 7141 GTGTCTTAGG CCAAGGAACC TCACTGTGGG TTCCCACAGA GGCTACCAAT TACATGTATC 7201 CTACTCTCGG GGCTAGGGGT TGGGGTGACC CTGCATGCTG TGTCCCTAAC CACAAGACCC 7261 CCTTCTTTCT TCAGTGGTGT TCTCCATGTC CTTTGTACAA GGAGAAGAAA GTAATGACAA 7321 AATACCTGTG GCCTTGGGCC TCAAGGAAAA GAATCTGTAC CTGTCCTGCG TGTTGAAAGA 7381 TGATAAGCCC ACTCTACAGC TGGAGGTAAG TGAATGCTAT GGAATGAAGC CCTTCTCAGC 7441 CTCCTGCTAC CACTTATTCC CAGACAATTC ACCTTCTCCC CGCCCCCATC CCTAGGAAAA 7501 GCTGGGAACA GGTCTATTTG ACAAGTTTTG CATTAATGTA AATAAATTTA ACATAATTTT 7561 TAACTGCGTG CAACCTTCAA TCCTGCTGCA GAAAATTAAA TCATTTTGCC GATGTTATTA 7621 TGTCCTACCA TAGTTACAAC CCCAACAGAT TATATATTGT TAGGGCTGCT CTCATTTGAT 7681 AGACACCTTG GGAAATAGAT GACTTAAAGG GTCCCATTAT CACGTCCACT CCACTCCCAA 7741 AATCACCACC ACTATCACCT CCAGCTTTCT CAGCAAAAGC TTCATTTCCA AGTTGATGTC 7801 ATTCTAGGAC CATAAGGAAA AATACAATAA AAAGCCCCTG GAAACTAGGT ACTTCAAGAA 7861 GCTCTAGCTT AATTTTCACC CCCCCAAAAA AAAAAAATTC TCACCTACAT TATGCTCCTC EPI-109 675

7921 AGCATTTGGC ACTAAGTTTT AGAAAAGAAG AAGGGCTCTT TTAATArt -n ^rt^H^AAAGT

7981 TGGGGGCCCA GTTACAACTC AGGAGTCTGG CTCCTGATCA TGTGACCTGC TCGTCAGTTT 8041 CCTTTCTGGC CAACCCAAAG AACATCTTTC CCATAGGCAT CTTTGTCCCT TGCCCCACAA 8101 AAATTCTTCT TTCTCTTTCG CTGCAGAGTG TAGATCCCAA AAATTACCCA AAGAAGAAGA 8161 TGGAAAAGCG ATTTGTCTTC AACAAGATAG AAATCAATAA CAAGCTGGAA TTTGAGTCTG 8221 CCCAGTTCCC CAACTGGTAC ATCAGCACCT CTCAAGCAGA AAACATGCCC GTCTTCCTGG 8281 GAGGGACCAA AGGCGGCCAG GATATAACTG ACTTCACCAT GCAATTTGTG TCTTCCTAAA 8341 GAGAGCTGTA CCCAGAG.AGT CCTGTGCTGA ATGTGGACTC AATCCCTAGG GCTGGCAGAA 8401 AGGGAACAGA AAGGTTTTTG AGTACGGCTA TAGCCTGGAC TTTCCTGTTG TCTACACCAA 8461 TGCCCAACTG CCTGCCTTAG GGTAGTGCTA AGAGGATCTC CTGTCCATCA GCCAGGACAG 8521 TCAGCTCTCT CCTTTCAGGG CCAATCCCCA GCCCTTTTGT TGAGCCAGGC CTCTCTCACC 8581 TCTCCTACTC ACTTAAAGCC CGCCTGACAG AAACCACGGC CACATTTGGT TCTAAGAAAC

8641 CCTCTGTCAT TCGCTCCCAC ATTCTGATGA GCAACCGCTT CCCTATTTAT TTATTTATTT 8701 GTTTGTTTGT TTTGATTCAT TGGTCTAATT TATTCAAAGG GGGCAAGAAG TAGCAGTGTC 8761 TGTAAAAGAG CCTAGTTTTT AATAGCTATG GAATCAATTC AATTTGGACT GGTGTGCTCT 8821 CTTTAAATCA AGTCCTTTAA TTAAGACTGA AAATATATAA GCTCAGATTA TTTAAATGGG 8881 AATATTTATA AATGAGCAAA TATCATACTG TTCAATGGTT CTGAAATAAA CTTCACTGAA 8941 GAAAAAAAAA AAAGGGTCTC TCCTGATCAT TGACTGTCTG GATTGACACT GACAGTAAGC 9001 AAACAGGCTG TGAGAGTTCT TGGGACTAAG CCCACTCCTC ATTGCTGAGT GCTGCAAGTA 9061 CCTAGAAATA TCCTTGGCCA CCGAAGACTA TCCTCCTCAC CCATCCCCTT TATTTCGTTG 9121 TTCAACAGAA GGATATTCAG TGCACATCTG GAACAGGATC AGCTGAAGCA CTGCAGGGAG 9181 TCAGGACTGG TAGTAACAGC TACCATGATT TATCTATCAA TGCACCAAAC ATCTGTTGAG 9241 CAAGCGCTAT GTACTAGGAG CTGGGAGTAC AGAGATGAGA ACAGTCACAA GTCCCTCCTC 9301 AGATAGGAGA GGCAGCTAGT TATAAGCAGA ACAAGGTAAC ATGACAAGTA GAGTAAGATA 9361 GAAGAACGAA GAGGAGTAGC CAGGAAGGAG GGAGGAGAAC GACATAAGAA TCAAGCCTAA 9421 AGGGATAAAC AGAAGATTTC CACACATGGG CTGGGCCAAT TGGGTGTCGG TTACGCCTGT 9481 AATCCCAGCA CTTTGGGTGG CAGGGGCAGA AAGATCGCTT GAGCCCAGGA GTTCAAGACC 9541 AGCCTGGGCA ACATAGTGAG ACTCCCATCT CTACAAAAAA TAAATAAATA AATAAAACAA 9601 TCAGCCAGGC ATGCTGGCAT GCACCTGTAG TCCTAGCTAC TTGGGAAGCT GACACTGGAG 9661 GATTGCTTGA GCCCAGAAGT TCAAGACTGC AGTGAGCTTA TCCGTTGACC TGCAGGTCGA 9721 C

(2) INFORMATION FOR SEQ ID NO: 2513: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1496 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2513:

1 ACAAACCTTT TCGAGGCAAA AGGCAAAAAA GGCTGCTCTG GGATTCTCTT CAGCCAATCT

61 TCAATGCTCA AGTGTCTGAA GCAGCCATGG CAGAAGTACC TAAGCTCGCC AGTGAAATGA

121 TGGCTTATTA CAGTGGCAAT GAGGATGACT TGTTCTTTGA AGCTGATGGC CCTAAACAGA

181 TGAAGTGCTC CTTCCAGGAC CTGGACCTCT GCCCTCTGGA TGGCGGCATC CAGCTACGAA

241 TCTCCGACCA CCACTACAGC AAGGGCTTCA GGCAGGCCGC GTCAGTTGTT GTGGCCATGG

301 ACAAGCTGAG GAAGATGCTG GTTCCCTGCC CACAGACCTT CCAGGAGAAT GACCTGAGCA

361 CCTTCTTTCC CTTCATCTTT GAAGAAGAAC CTATCTTCTT CGACACATGG GATAACGAGG

421 CTTATGTGCA CGATGCACCT GTACGATCAC TGAACTGCAC GCTCCGGGAC TCACAGCAAA

481 AAAGCTTGGT GATGTCTGGT CCATATGAAC TGAAAGCTCT CCACCTCCAG GGACAGGATA

541 TGGAGCAACA AGTGGTGTTC TCCATGTCCT TTGTACAAGG AGAAGAAAGT AATGACAAAA

601 TACCTGTGGC CTTGGGCCTC AAGGAAAAGA ATCTGTACCT GTCCTGCGTG TTGAAAGATG

661 ATAAGCCCAC TCTACAGCTG GAGAGTGTAG ATCCCAAAAA TTACCCAAAG AAGAAGATGG

721 AAAAGCGATT TGTCTTCAAC AAGATAGAAA TCAATAACAA GCTGGAATTT GAGTCTGCCC

781 AGTTCCCCAA CTGGTACATC AGCACCTCTC AAGCAGAAAA CATGCCCGTC TTCCTGGGAG

841 GGACCAAAGG CGGCCAGGAT ATAACTGACT TCACCATGCA ATTTGTGTCT TCCTAAAGAG

901 AGCTGTACCC AGAGAGTCCT GTGCTGAATG TGGACTCAAT CCCTAGGGCT GGCAGAAAGG

961 GAACAGAAAG GTTTTTGAGT ACGGCTATAG CCTGGACTTT CCTGTTGTCT ACACCAATGC

1021 CCAACTGCCT GCCTTAGGGT AGTGCTAAGA GGATCTCCTG TCCATCAGCC AGGACAGTCA

1081 GCTCTCTCCT TTCAGGGCCA ATCCCAGCCC TTTTGTTGAG CCAGGCCTCT CTCACCTCTC

1141 CTACTCACTT AAAGCCCGCC TGACAGAAAC CAGGCCACAT TTTGGTTCTA AGAAACCCTC

1201 CTCTGTCATT CGCTCCCACA TTCTGATGAG CAACCGCTTC CCTATTTATT TATTTATTTG

1261 TTTGTTTGTT TTGATTCATT GGTCTAATTT ATTCAAAGGG GGCAAGAAGT AGCAGTGTCT

1321 GTAAAAGAGC CTAGTTTTTA ATAGCTATGG AATCAATTCA ATTTGGACTG GTGTGCTCTC

1381 TTTAAATCAA GTCCTTTAAT TAAGACTGAA AATATATAAG CTCAGATTAT TTAAATGGGA

1441 ATATTTATAA ATGAGCAAAT ATCATACTGT TCAATGGTTC TCAAATAAAC TTCACT

(2) INFORMATION FOR SEQ ID NO: 2514: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 720 base pairs

(B) TYPE: nucleic acid EPI-109 676

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2514:

1 CTGGCAGGAG TAGCAGCTGC CCCTTGGCGC GACTGCTGGA GCCGCGAACT AGAGAAACAC

61 AGACACGCCT CATAGAGCAA CGGCGTCTCT CGGAGCGTGG AGCCCGCCAA GCTCGAGCTG

121 AGCTTTCGCT TGCCGTCCAC CACTGCCCAC ACTGTCGTTT GCTGCCATCG CAGACCTGCT

181 GCTGACTTCC ATCCCTCTGG ATCCGGCAAG GGCCTGCGAT TTTGACAATG TCAAGATTTA

241 CCGTATATCC CTGTTTGTTT GGATACACCA GTGACGTCCA CTTCTAGAAG ACAAAGTTAT

301 ATTACTTAAA CAACCAAAGA TATGAAACTA TCCATGAAGA ACAATATTAT CAATACACAG

361 CAGTCTTTTG TAACCATGCC CAATGTGATT GTACCAGATA TTGAAAAGGA AATACGAAGG

421 ATGGAAAATG GAGCATGCAG CTCCTTTTCT GAGGATGATG ACAGTGCCTC TACATCTGAA

481 GAATCAGAGA ATGAAAACCC TCATGCAAGG GGTTCCTTTA GTTATAAGTC ACTCAGAAAG

541 GGAGGACCAT CACAGAGGGA GCAGTACCTG CCTGGTGCCA TTGCCATTTT TAATGTGAAC

601 AACAGCGACA ATAAGGACCA GGAACCAGAA GAAAAAAAGA AAAAGAAAAA AGAAAAGAAG

661 AGCAAGTCAG ATGATAAAAA CGAAAATAAA AACGACCCAA AGAAGAAGAT GGAAAAGCGA

(2) INFORMATION FOR SEQ ID NO:2515: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2002 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2515: 1 atggccaaag ttccagacat gtttgaagac ctgaagaact gttacagtga aaatgaagaa

61 gacagttcct ccattgatca tctgtctctg aatcagaaat ccttctatca tgtaagctat 121 ggcccactcc atgaaggctg catggatcaa tctgtgtctc tgagtatctc tgaaacctct 181 aaaacatcca agcttacctt caaggagagc atggtggtag tagcaaccaa cgggaaggtt 241 ctgaagaaga gacggttgag tttaagccaa tccatcactg atgatgacct ggaggccatc 301 gccaatgact cagaggaaga aatcatcaag cctaggtcag caccttttag cttcctgagc

361 aatgtgaaat acaactttat gaggatcatc aaatacgaat tcatcctgaa tgacgccctc 421 aatcaaagta taattcgagc caatgatcag tacctcacgg ctgctgcatt acataatctg

481 gatgaagcag tgaaatttga catgggtgct tataagtcat caaaggatga tgctaaaatt 541 accgtgattc taagaatctc aaaaactcaa ttgtatgtga ctgcccaaga tgaagaccaa 601 ccagtgctgc tgaaggagat gcctgagata cccaaaacca tcacaggtag tgagaccaac 661 ctcctcttct tctgggaaac tcacggcact aagaactatt tcacatcagt tgcccatcca 721 aacttgttta ttgccacaaa gcaagactac tgggtgtgct tggcaggggg gccaccctct 781 atcactgact ttcagatact ggaaaaccag gcgtaggtct ggagtctcac ttgtctcact 841 tgtgcagtgt tgacagttca tatgtaccat gtacatgaag aagctaaatc ctttactgtt 901 agtcatttgc tgagcatgta ctgagccttg taattctaaa tgaatgttta cactctttgt 961 aagagtggaa ccaacactaa catataatgt tgttatttaa agaacaccct atattttgca

1021 tagtaccaat cattttaatt attattcttc ataacaattt taggaggacc agagctactg 1081 actatggcta ccaaaaagac tctacccata ttacagatgg gcaaattaag gcataagaaa 1141 actaagaaat atgcacaata gcagttgaaa caagaagcca cagacctagg atttcatgat 1201 ttcatttcaa ctgtttgcct tctgctttta agttgctgat gaactcttaa tcaaatagca 1261 taagtttctg ggacctcagt tttatcattt tcaaaatgga gggaataata cctaagcctt 1321 cctgccgcaa cagtttttta tgctaatcag ggaggtcatt ttggtaaaat acttctcgaa 1381 gccgagcctc aagatgaagg caaagcacga aatgttattt tttaattatt atttatatat 1441 gtatttataa atatatttaa gataattata atatactata tttatgggaa ccccttcatc 1501 ctctgagtgt gaccaggcat cctccacaat agcagacagt gttttctggg ataagtaagt 1561 ttgatttcat taatacaggg cattttggtc caagttgtgc ttatcccata gccaggaaac 1621 tctgcattct agtacttggg agacctgtaa tcatataata aatgtacatt aattaccttg 1681 agccagtaat tggtccgatc tttgactctt ttgccattaa acttacctgg gcattcttgt 1741 ttcattcaat tccacctgca atcaagtcct acaagctaaa attagatgaa ctcaactttg 1801 acaaccatag accactgtta tcaaaacttt cttttctgga atgtaatcaa tgtttcttct 1861 aggttctaaa aattgtgatc agaccataat gttacattat tatcaacaat agtgattgat 1921 agagtgttat cagtcataac taaataaagc ttgcaagtga gggagtcatt tcattggcgt 1981 ttgagtcagc aaagaagtca ag

(2) INFORMATION FOR SEQ ID NO: 2516: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2027 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2516:

1 AGCTGCCAGC CAGAGAGGGA GTCATTTCAT TGGCGTTTGA GTCAGCAAAG AAGTCAAGAT

61 GGCCAAAGTT CCAGACATGT TTGAAGACCT GAAGAACTGT TACAGTGAAA ATGAAGAAGA

121 CAGTTCCTCC ATTGATCATC TGTCTCTGAA TCAGAAATCC TTCTATCATG TAAGCTATGG

181 CCCACTCCAT GAAGGCTGCA TGGATCAATC TGTGTCTCTG AGTATCTCTG AAACCTCTAA

241 AACATCCAAG CTTACCTTCA AGGAGAGCAT GGTGGTAGTA GCAACCAACG GGAAGGTTCT EPI-109 677

301 GAAGAAGAGA CGGTTGAGTT TAAGCCAATC CATCACTGAT GATGACC . ^ AGGCCATCGC

361 CAATGACTCA GAGGAAGAAA TCATCAAGCC TAGGTCATCA CCTTTTAGCT TCCTGAGCAA

421 TGTGAAATAC AACTTTATGA GGATCATCAA ATACGAATTC ATCCTGAATG ACGCCCTCAA

481 TCAAAGTATA ATTCGAGCCA ATGATCAGTA CCTCACGGCT GCTGCATTAC ATAATCTGGA

541 TGAAGCAGTG AAATTTGACA TGGGTGCTTA TAAGTCATCA AAGGATGATG CTAAAATTAC

601 CGTGATTCTA AGAATCTCAA AAACTCAATT GTATGTGACT GCCCAAGATG AAGACCAACC

661 AGTGCTGCTG AAGGAGATGC CTGAGATACC CAAAACCATC ACAGGTAGTG AGACCAACCT

721 CCTCTTCTTC TGGGAAACTC ACGGCACTAA GAACTATTTC ACATCAGTTG CCCATCCAAA

781 CTTGTTTATT GCCACAAAGC AAGACTACTG GGTGTGCTTG GCAGGGGGGC CACCCTCTAT

841 CACTGACTTT CAGATACTGG AAAACCAGGC GTAGGTCTGG AGTCTCACTT GTCTCACTTG

901 TGCAGTGTTG ACAGTTCATA TGTACCATGT ACATGAAGAA GCTAAATCCT TTACTGTTAG

961 TCATTTGCTG AGCATGTACT GAGCCTTGTA ATTCTAAATG AATGTTTACA CTCTTTGTAA

1021 GAGTGGAACC AACACTAACA TATAATGTTG TTATTTAAAG AACACCCTAT ATTTTGCATA

1081 GTACCAATCA TTTTAATTAT TATTCTTCAT AACAATTTTA GGAGGACCAG AGCTACTGAC

1141 TATGGCTACC AAAAAGACTC TACCCATATT ACAGATGGGC AAATTAAGGC ATAAGAAAAC

1201 TAAGAAATAT GCACAATAGC AGTCGAAACA AGAAGCCACA GACCTAGGAT TTCATGATTT

1261 CATTTCAACT GTTTGCCTTC TGCTTTTAAG TTGCTGATGA ACTCTTAATC AAATAGCATA

1321 AGTTTCTGGG ACCTCAGTTT TATCATTTTC AAAATGGAGG GAATAATACC TAAGCCTTCC

1381 TGCCGCAACA GTTTTTTATG CTAATCAGGG AGGTCATTTT GGTAAAATAC TTCTCGAAGC

1441 CGAGCCTCAA GATGAAGGCA AAGCACGAAA TGTTATTTTT TAATTATTAT TTATATATGT

1501 ATTTATAAAT ATATTTAAGA TAATTATAAT ATACTATATT TATGGGAACC CCTTCATCCT

1561 CTGAGTGTGA CCAGGCATCC TCCACAATAG CAGACAGTGT TTTCTGGGAT AAGTAAGTTT

1621 GATTTCATTA ATACAGGGCA TTTTGGTCCA AGTTGTGCTT ATCCCATAGC CAGGAAACTC

1681 TGCATTCTAG TACTTGGGAG ACCTGTAATC ATATAATAAA TGTACATTAA TTACCTTGAG

1741 CCAGTAATTG GTCCGATCTT TGACTCTTTT GCCATTAAAC TTACCTGGGC ATTCTTGTTT 1801 CATTCAATTC CACCTGCAAT CAAGTCCTAC AAGCTAAAAT TAGATGAACT CAACTTTGAC

1861 AACCATGAGA CCACTGTTAT CAAAACTTTC TTTTCTGGAA TGTAATCAAT GTTTCTTCTA 1921 GGTTCTAAAA ATTGTGATCA GACCATAATG TTACATTATT ATCAACAATA GTGATTGATA 1981 GAGTGTTATC AGTCATAACT AAATAAAGCT TGCAACAAAA TTCTCTG

( 2 ) INFORMATION FOR SEQ ID NO : 2517 : ( i ) SEQUENCE CHARACTERISTICS :

(A) LENGTH : base pairs

(B) TYPE : 29433 nucleic acid

(C) STRANDEDNESS : single

( D) TOPOLOGY : linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2517:

1 AAGCTTCTAC CCTAGTCTGG TGCTACACTT ACATTGCTTA CATCCAAGTG TGGTTATTTC

61 TGTGGCTCCT GTTATAACTA TTATAGCACC AGGTCTATGA CCAGGAGAAT TAGACTGGCA

121 TTAAATCAGA ATAAGAGATT TTGCACCTGC AATAGACCTT ATGACACCTA ACCAACCCCA

181 TTATTTACAA TTAAACAGGA ACAGAGGGAA TACTTTATCC AACTCACACA AGCTGTTTTC

241 CTCCCAGATC CATGCTTTTT TGCGTTTATT ATTTTTTAGA GATGGGGGCT TCACTATGTT

301 GCCCACACTG GACTAAAACT CTGGGCCTCA AGTGATTGTC CTGCCTCAGC CTCCTGAATA

361 GCTGGGACTA CAGGGGCATG CCATCACACC TAGTTCATTT CCTCTATTTA AAATATACAT

421 GGCTTAAACT CCAACTGGGA ACCCAAAACA TTCATTTGCT AAGAGTCTGG TGTTCTACCA

481 CCTGAACTAG GCTGGCCACA GGAATTATAA AAGCTGAGAA ATTCTTTAAT AATAGTAACC

541 AGGCAACATC ATTGAAGGCT CATATGTAAA AATCCATGCC TTCCTTTCTC CCAATCTCCA

601 TTCCCAAACT TAGCCACTGG TTCTGGCTGA GGCCTTACGC ATACCTCCCG GGGCTTGCAC

661 ACACCTTCTT CTACAGAAGA CACACCTTGG GCATATCCTA CAGAAGACCA GGCTTCTCTC

721 TGGTCCTTGG TAGAGGGCTA CTTTACTGTA ACAGGGCCAG GGTGGAGAGT TCTCTCCTGA

781 AGCTCCATCC CCTCTATAGG AAATGTGTTG ACAATATTCA GAAGAGTAAG AGGATCAAGA

841 CTTCTTTGTG CTCAAATACC ACTGTTCTCT TCTCTACCCT GCCCTAACCA GGAGCTTGTC

901 ACCCCAAACT CTGAGGTGAT TTATGCCTTA ATCAAGCAAA CTTCCCTCTT CAGAAAAGAT

961 GGCTCATTTT CCCTCAAAAG TTGCCAGGAG CTGCCAAGTA TTCTGCCAAT TCACCCTGGA

1021 GCACAATCAA CAAATTCAGC CAGAACACAA CTACAGCTAC TATTAGAACT ATTATTATTA

1081 ATAAATTCCT CTCCAAATCT AGCCCCTTGA CTTCGGATTT CACGATTTCT CCCTTCCTCC

1141 TAGAAACTTG ATAAGTTTCC CGCGCTTCCC TTTTTCTAAG ACTACATGTT TGTCATCTTA

1201 TAAAGCAAAG GGGTGAATAA ATGAACCAAA TCAATAACTT CTGGAATATC TGCAAACAAC

1261 AATAATATCA GCTATGCCAT CTTTCACTAT TTTAGCCAGT ATCGAGTTGA ATGAACATAG

1321 AAAAATACAA AACTGAATTC TTCCCTGTAA ATTCCCCGTT TTGACGACGC ACTTGTAGCC

1381 ACGTAGCCAC GCCTACTTAA GACAATTACA AAAGGCGAAG AAGACTGACT CAGGCTTAAG

1441 CTGCCAGCCA GAGAGGGAGT CATTTCATTG GCGTTTGAGT CAGCAAAGGT ATTGTCCTCA

1501 CATCTCTGGC TATTAAAGTA TTTTCTGTTG TTGTTTTTCT CTTTGGCTGT TTTCTCTCAC

1561 ATTGCCTTCT CTAAAGCTAC AGTCTCTCCT TTCTTTTCTT GTCCCTCCCT GGTTTGGTAT

1621 GTGACCTAGA ATTACAGTCA GATTTCAGAA AATGATTCTC TCATTTTGCT GATAAGGACT

1681 GATTCGTTTT ACTGAGGGAC GGCAGAACTA GTTTCCTATG AGGGCATGGG TGAATACAAC

1741 TGAGGCTTCT CATGGGAGGG AATCTCTACT ATCCAAAATT ATTAGGAGAA AATTGAAAAT

1801 TTCCAACTCT GTCTCTCTCT TACCTCTGTG TAAGGCAAAT ACCTTATTCT TGTGGTGTTT

1861 TTGTAACCTC TTCAAACTTT CATTGATTGA ATGCCTGTTC TGGCAATACA TTAGGTTGGG EPI-109 678

1921 CACATAAGGA ATACCAACAT AAATAAAACA TTCTAAAAGA AGTTTACGAT CTAATAAAGG 1981 AGACAGGTAC ATAGCAAACT AATTCAAAGG AGCTAGAAGA TGGAGAAAAT GCTGAATGTG 2041 GACTAAGTCA TTCAACAAAG TTTTCAGGAA GCACAAAGAG GAGGGGCTCC CCTCACAGAT 2101 ATCTGGATTA GAGGCTGGCT GAGCTGATGG TGGCTGGTGT TCTCTGTTGC AGAAGTCAAG 2161 ATGGCCAAAG TTCCAGACAT GTTTGAAGAC CTGAAGAACT GTTACAGGTA AGGAATAAGA 2221 TTTATCTCTT GTGATTTAAT GAGGGTTTCA AGGCTCACCA GAATCCAGCT AGGCATAACA 2281 GTGGCCAGCA TGGGGGCAGG CCGGCAGAGG TTGTAGAGAT GTGTACTAGT CCTGAAGTCA 2341 GAGCAGGTTC AGAGAAGACC CAGAAAAACT AAGCATTCAG CATGTTAAAC TGAGATTACA 2401 TTGGCAGGGA GACCGCCATT TTAGAAAAAT TATTTTTGAG GTCTGCTGAG CCCTACATGA 2461 ATATCAGCAT CAACTTAGAC ACAGCCTCTG TTGAGATCAC ATGCCCTGAT ATAAGAATGG 2521 GTTTTACTGG TCCATTCTCA GGAAAACTTG ATCTCATTCA GGAACAGGAA ATGGCTCCAC 2581 AGCAAGCTGG GCATGTGAAC TCACATATGC AGGCAAATCT CACTCAGATG TAGAAGAAAG 26 1 GTAAATGAAC ACAAAGATAA AATTACGGAA CATATTAAAC TAACATGATG TTTCCATTAT 2701 CTGTAGTAAA TACTAACACA AACTAGGCTG TCAAAATTTT GCCTGGATAT TTTACTAAGT 2761 ATAAATTATG AAATCTGTTT TAGTGAATAC ATGAAAGTAA TGTGTAACAT ATAATCTATT 2821 TGGTTAAAAT AAAAAGGAAG TGCTTCAAAA CCTTTCTTTT CTCTAAAGGA GCTTAACATT 2881 CTTCCCTGAA CTTCAATTAA AGCTCTTCAA TTTGTTAGCC AAGTCCAATT TTTACAGATA 2941 AAGCACAGGT AAAGCTCAAA GCCTGTCTTG ATGACTACTA ATTCCAGATT AGTAAGATAT 3001 GAATTACTCT ACCTATGTGT ATGTGTAGAA GTCCTTAAAT TTCAAAGATG ACAGTAATGG 3061 CCATGTGTAT GTGTGTGACC CACAACTATC ATGGTCATTA AAGTACATTG GCCAGAGACC 3121 ACATGAAATA ACAACAATTA CATTCTCATC ATCTTATTTT GACAGTGAAA ATGAAGAAGA 3181 CAGTTCCTCC ATTGATCATC TGTCTCTGAA TCAGGTAAGC AAATGACTGT AATTCTCATG 3241 GGACTGCTAT TCTTACACAG TGGTTTCTTC ATCCAAAGAG AACAGCAATG ACTTGAATCT 3301 TAAATACTTT TGTTTTACCC TCACTAGAGA TCCAGAGACC TGTCTTTCAT TATAAGTGAG 3361 ACCAGCTGCC TCTCTAAACT AATAGTTGAT GTGCATTGGC TTCTCCCAGA ACAGAGCAGA 3421 ACTATCCCAA ATCCCTGAGA ACTGGAGTCT CCTGGGGCAG GCTTCATCAG GATGTTAGTT 3481 ATGCCATCCT GAGAAAGCCC CGCAGGCCGC TTCACCAGGT GTCTGTCTCC TAACGTGATG 3541 TGTTGTGGTT GTCTTCTCTG ACACCAGCAT CAGAGGTTAG AGAAAGTCTC CAAACATGAA 3601 GCTGAGAGAG AGGAAGCAAG CCAGCTGAAA GTGAGAAGTC TACAGCCACT CATCAATCTG 3661 TGTTATTGTG TTTGGAGACC ACAAATAGAC ACTATAAGTA CTGCCTAGTA TGTCTTCAGT 3721 ACTGGCTTTA AAAGCTGTCC CCAAAGGAGT ATTTCTAAAA TATTTTGAGC ATTGTTAAGC 3781 AGATTTTTAA CCTCCTGAGA GGGAACTAAT TGGAAAGCTA CCACTCACTA CAATCATTGT 3841 TAACCTATTT AGTTACAACA TCTCATTTTT GAGCATGCAA ATAAATGAAA AAGTCTTCCT 3901 AAAAAAATCA TCTTTTTATC CTGGAAGGAG GAAGGAAGGT GAGACAAAAG GGAGAGAGGG 3961 AGGGAAGCCT AATGAAACAC CAGTTACCTA AGACCAGAAT GGAGATCCTC CTCACTACCT 4021 CTGTTGAATA CAGCACCTAC TGAAAGAACT TTCATTCCCT GACCATGAAC AGCCTCTCAG 4081 CTTCTGTTTT CCTTCCTCAC AGAAATCCTT CTATCATGTA AGCTATGGCC CACTCCATGA 4141 AGGCTGCATG GATCAATCTG TGTCTCTGAG TATCTCTGAA ACCTCTAAAA CATCCAAGCT 4201 TACCTTCAAG GAGAGCATGG TGGTAGTAGC AACCAACGGG AAGGTTCTGA AGAAGAGACG 4261 GTTGAGTTTA AGCCAATCCA TCACTGATGA TGACCTGGAG GCCATCGCCA ATGACTCAGA 4321 GGAAGGTAAG GGGTCAAGCA CAATAATATC TTTCTTTTAC AGTTTTAAGC AAGTAGGGAC 4381 AGTAGAATTT AGGGGAAAAT TAAACGTGGA GTCAGAATAA CAAGAAGACA ACCAAGCATT 4441 AGTCTGGTAA CTATACAGAG GAAAATTAAT TTTTATCCTT CTCCAGGAGG GAGAAATGAG 4501 CAGTGGCCTG AATCGAGAAT ACTTGCTCAC AGCCATTATT TCTTAGCCAT ATTGTAAAGG 4561 TCGTGTGACT TTTAGCCTTT CAGGAGAAAG CAGTAATAAG ACCACTTACG AGCTATGTTC 4621 CTCTCATACT AACTATGCCT CCTTGGTCAT GTTACATAAT CTTTTCGTGA TTCAGTTTCC 4681 TCTACTGTAA AATGGAGATA ATCAGAATCC CCCACTCATT GGATTGTTGT AAAGATTAAG 4741 AGTCTCAGGC TTTACAGACT GAGCTAGCTG GGCCCTCCTG ACTGTTATAA AGATTAAATG 4801 AGTCAACATC CCCTAACTTC TGGACTAGAA TAATGTCTGG TACAAAGTAA GCACCCAATA 4861 AATGTTAGCT ATTACTATCA TTATTATTAT TATTTTATTT TTTTTTTTTG AGATGGAGTC 4921 TGGCTCTGTC ACCCAGGCTG GAGTGCAGTG GCACAATCTC GGCTCACTGC AAGCTCTGCC 4981 TCCTGGGTTC ATGCCATTCT CCTGCCTCAG CCTCCCGAGT AAGCTGGGAA TACAGGCACC 5041 CGCCACTGTT CCCGGCTAAT TTTTTGTATT TTTAGTAGAG ACGGAGTTTC ACCGTGGTCT 5101 CCATCTCCTC GTGATCCACC CACCTTGGCC TCCCAAAGTG CCGGGATTAC AGGCGTGAGC 5161 CACCGCGCCC GGCCTATTAT TATTATTATT ACTACTACTA CTACCTATAT GAATACTACC 5221 AGCAATACTA ATTTATTAAT GACTGGATTA TGTCTAAACC TCACAAGAAT CCTACCTTCT 5281 CATTTTACAT AAAAGGAAAC TAAGCTCATT GAGATAGGTA AACTGCCCAA TGGCATACAT 5341 CTGTAAGTGG GAGAGCCTCA AATCTAATTC AGTTCTACCT GAGTAAAAAA ATCATGGTTT 5401 CTCCTCCATC CCTTTACTGT ACAAGCCTCC ACATGAACTA TAAACCCAAT ATTCCTGTTT 5461 TTAAGATAAT ACCTAAGCAA TAACGCATGT TCACCTAGAA GGTTTTAAAA TGTAACAAAA 5521 TATAAGAAAA TAAAAATCAC TCATATCGTC AGTGAGAGTT TACTACTGCC AGCACTATGG 5581 TATGTTTCCT TAAAATCTTT GCTATACACA TACCTACATG TGAACAAATA TGTCTAACAT 5641 CAAGACCACA CTATTTACAA CTTTATATCC AGCTTTTCTT ACTTAGCAAT GTATTGAGGA 5701 CATTTTAGAG TGCCCGTTTT TCACCATTAT AAGCAATGCA ACAATGAACA TCTGTATAAA 5761 TAAATATTCA TTTCTCTCAC CCTTTATTTC CTTAGAATAT ATTCCTAGAA GTAGAATTTC 5821 CCAGAGCCAT GAGGATTTGT GACGCTATTG ATATGTGCCA CTTTGCACTC TCTGTGACAT 5881 ATATAATTAT TTTTAATGCA TTCATTTTTT TCTCAGAGTG CATTCGTTTG AAAACATAGA 5941 CGGGAAATAC TGGTAGTCTT CCTTGTCAGT TAGAAACACC CAAACAATGA AAAATGAAAA EPI-109 679

6001 AGTTGCACAA ATAGTCTCTA AAAACAATGA AACTATTGCC TGAGGAAϋ AAGTTTAAAA 6061 AGAAGCACAT AAGCAACAAC AAGGATAATC CTAGAAAACC AGTTCTGCTG ACTGGGTGAT 6121 TTCACTTCTC TTTGCTTCCT CATCTGGATT GGAATATTCC TAATACCCCC TCCAGAACTA 6181 TTTTCCCTGT TTGTACTAGA CTGTGTATAT CATCTGTGTT TGTACATAGA CATTAATCTG 6241 CACTTGTGAT CATGGTTTTA GAAATCATCA AGCCTAGGTC ATCACCTTTT AGCTTCCTGA 6301 GCAATGTGAA ATACAACTTT ATGAGGATCA TCAAATACGA ATTCATCCTG AATGACGCCC 6361 TCAATCAAAG TATAATTCGA GCCAATGATC AGTACCTCAC GGCTGCTGCA TTACATAATC 6421 TGGATGAAGC AGGTACATTA AAATGGCACC AGACATTTCT GTCATCCTCC CCTCCTTTCA 6481 TTTACTTATT TATTTATTTC AATCTTTCTG CTTGCAAAAA ACATACCTCT TCAGAGTTCT 6541 GGGTTGCACA ATTCTTCCAG AATAGCTTGA AGCACAGCAC CCCCATAAAA ATCCCAAGCC 6601 AGGGCAGAAG GTTCAACTAA ATCTGGAAGT TCCACAAGAG AGAAGTTTCC TATCTTTGAG 6661 AGTAAAGGGT TGTGCACAAA GCTAGCTGAT GTACTACCTC TTTGGTTCTT TCAGACATTC 6721 TTACCCTCAA TTTTAAAACT GAGGAAACTG TCAGACATAT TAAATGATTT ACTCAGATTT 6781 ACCCAGAAGC CAATGAAGAA CAATCACTCT CCTTTAAAAA GTCTGTTGAT CAAACTCACA 6841 AGTAACACCA AACCAGGAAG ATCTTTATTA TCTCTGATAA CATATTTGTG AGGCAAAACC 6901 TCCAATAAGC TACAAATATG GCTTAAAGGA TGAAGTTTAG TGTCCAAAAA CTTTTATCAC 6961 ACACATCCAA TTTTCATGGC GGACATGTTT TAGTTTCAAC AGTATACATA TTTTCAAAGG 7021 TCCAGAGAGG CAATTTTGCA ATAAACAAGC AAGACTTTTT CTGATTGGAT GCACTTCAGC 7081 TAACATGCTT TCAACTCTAC ATTTACAAAT TATTTTGTGT TCTATTTTTC TACTTAATAT 7141 TATTTCTGCA ATTTTCCCAA TATTGACATC GTGTATGTAT TTGCCATTTT TAATATCACT 7201 AGACAATTCA ATCAGGTTGC TACGTTGGTC CCTTGGGTTT ACTCTAAATA GCTTGATTGC 7261 AAATATCTTT GTATATATTA TTGTTTTTTC TCCTATCTTG TAATTTCTTT GAGCACATCC 7321 CAAAGAGGAA TGCCTAGATC AATGGGCACA AATAATTTGA CAGCTCTTAT TAAACATTAT 7381 TCTGTAAGTA AAAACTGAAC TACTTTTCAG TATCACTAGC AACATATGAG TGTATCAGCT 7441 TCCTAAACCC CTCCATGTTA GGTCATTATG AACTTATGAT CTAACAAATT ACAGGGTCTT 7501 ATCCCACTAA TGAAATTATA AGAGATTCAA CACTTATTCA GCCCCGAAGG ATTCATTCAA 7561 CGTAGAAAAT TCTAAGAACA TTAACCAAGT ATTTACCTGC CTAGTGAGTG TGGAAGACAT 7621 TGTGAAGGAC ACAAAGATGT ATAGAATTCC ATTCCTGACT TCCAGGTATT TACACCATAG 7681 GTGGGGACCT AACTACACAC ACACACACAC ACACACACAC ACACACACAC ACCATGCACA 7741 CACAATCTAC ATCAACACTT GATTTTATAC AAATACAATG AATTTACTTT CTTTTTGGTT 7801 CTTCTCTTCA CCAGTGAAAT TTGACATGGG TGCTTATAAG TCATCAAAGG ATGATGCTAA 7861 AATTACCGTG ATTCTAAGAA TCTCAAAAAC TCAATTGTAT GTGACTGCCC AAGATGAAGA 7921 CCAACCAGTG CTGCTGAAGG TCAGTTGTCC TTTGTCTCCA ACTTACCTTC ATTTACATCT 7981 CATATGTTTG TAAATAAGCC CAATAGGCAG ACACCTCTAA CAAGGTGACA CTGTCCTCTT 8041 TCCTTCCTAC CACAGCCCCC ACCTACCCAC CCCACTCCCA TTGATTCCAG AGGCGTGCCT 8101 AGGCAGGATC TATGAGAAAA TATAACAGAG AGTAAGAGGA AAATTACCTT CTTTCTTTTT 8161 CCTTTCCCTG CCTGACCTTA TTCACCTCCC ATCCCAGAGC ATCCATTTAT TCCATTGATC 8221 TTTACTGACA TCTATTATCT GACCTACACA ATACTAGACA TTAGGACAAT GTGGCCTGCC 8281 TCCAAGAAAC TCAAATAAGC CAACTGAGAT CAGAGAGGAT TAATCACCTG CCAATGGGCA 8341 CAAAGCAACA AGCTGGGAGC CAAGTCCCAA AATGGGGCCT GCTGCTTCCA GTTCCCCTCT 8401 CTCTGCATTG ATGTCAGCAT TATCCTTCGT CCCAGTCCTG TCTCCACTAC CACTTTCCCC 8461 CTCAAACACA CACACACACA ACAGCCTTAG ATGTTTTCTC CACTGATAAG TAGGTGACTC 8521 AATTTGTAAG TATATAATCC AAGACCTTCT ATTCCCAAGT AGAATTTATG TGCCTGCCTG 8581 TGCTTTTCTA CCTGGATCAA GTGATGTCTA CAGAGTAGGG CAGTAGCTTC ATTCATGAAC 8641 TCATTCAACA AGCATTATTC ACTGAGAGCC TTGTATTTTT CAGGCATAGT GCCAACAGCA 8701 GTGTGGACAG TGGTGCATCA AAGCCTCTAG TCTCATAGAA CTTAGTCTTC TGGAGGATAT 8761 GGAAAACAGA CAACCCAAAC AACCAACAAA AGAGCAAGAT GCTGCAAAAA AAAAAAAAAT 8821 GAATAGGGTG CTAAGATAGA GAAAAGTGGG AGAGTGCTAT TTAGACAAAG TGGTAAAAAC 8881 AAAGCCCCTT GTGAGATGAG AGCTGCCGAC AGAGGGGGCG GGTCATGGTT GTGGGTTTTT 8941 GGGTAGGACA TTCAGAGGAG GGGGCGGGTC GTGGTTGTGG GTTTTTGGGT AGGACATTCA 9001 GAGGAGGGGG CGGGTCGTGG TTGTGGGTTT TTGGGTAGGA CATTCAGAGG AGGGGGCGGG 9061 TCGTGGTTGT GGGTTTTTGG GTAGGACATT CAGAGGAGGG GGCGGGTCGT GGTTGTGGGT 9121 TTTTGGGACA TTCAGAGGAG TCTGAATGCA CCCAGGCCTA CAACTTCAAG ATGGTAAAGG 9181 ACAGCTCCAA GGATCAGAAG AAGCATTCTT GGAACTGGGG CATTTTGAGA AGGAGGAAAA 9241 ATATGCAGAG ACTAGTGCTT GCAGAGCTTG CATTTGGATT TCATTTGAGG TACAATGAAA 9301 ACCCATTAAT GGGTTTCACA CAGTGCAATG GCCTGACCTC ACTTATATTT CCTAAAATAG 9361 AAAACAGATC AGAAGGAAGG CAATAGAGAA GCAGAAAGTC CAATGAGGAG GTTTCACAGC 9421 AGTCATGGGG GTGGGGTAAG GAAAAGAAGT GGAAAGAAAC AGACAGAATT GGGTTATATT 9481 TTGGAGATAG AACCAACAGA AGGAAGAGGA GAAACAACAT TTACTGAGAA GGGAAAAAGT 9541 AGGAGAGGAA TAGGTTTGGG AAATAAATCC TGCTGACATT GGAAACCCCA AGGAAGCCTC 9601 AAAAGTATAT TTACTTGCTT TAGATTTAAA AGAATAGGAA AGAAGCATCT CAACTTGGAA 9661 TTTGAAATCT ATTTTTCCAT AAAAGTATTG TTAAATTCTA CTCATACTCA CAAGAAAAGT 9721 ACATTCTAAA GAGTATATTG AAAGAGTTTA CTGATATACT TAGGAATTTT GTGTGTATGT 9781 GTGTGTGTGT ATGTGTGTGT GTGTGTTTAA CCTTCAATTG TTGACTTAAA TACTGAGATA 9841 AATGTCATCT AAATGCTAAA TTGATTTCCC AAAGGTATGA TTTGTTCACT TGGAGATCAA 9901 AATGTTTAGG GGGCTTAGAA TCACTGTAGT GCTCAGATTT GATGCAAAAT GTCTTAGGCC 9961 TATGTTGAAG GCAGGACAGA AACAATGTTT CCCTCCTACC TGCCTGGATA CAGTAAGATA 10021 CTAGTGTCAC TGACAATCTT CATAACTAAT TTAGATCTCT CTCCAATCAA CTAAGGAAAT EPI-109 680

10081 CAACTCTTAT TAATAGACTG GGCCACACAT CTACTAGGCA TGTAATAAAT GCTTGCTGAA 10141 TGAACAAATG AATGAAGAGC CTATAGCATC ATGTTACAGC CATAGTCCTA AAGTGGTGTT 10201 TCTCATGAAG GCCAAATGCT AAGGGATTGA GCTTCAGTCC TTTTTCTAAC ATCTTGTTCT 10261 CTAACAGAAT TCTCTTCTTT TCTTCATAGG AGATGCCTGA GATACCCAAA ACCATCACAG 10321 GTAGTGAGAC CAACCTCCTC TTCTTCTGGG AAACTCACGG CACTAAGAAC TATTTCACAT 10381 CAGTTGCCCA TCCAAACTTG TTTATTGCCA CAAAGCAAGA CTACTGGGTG TGCTTGGCAG 10441 GGGGGCCACC CTCTATCACT GACTTTCAGA TACTGGAAAA CCAGGCGTAG GTCTGGAGTC 10501 TCACTTGTCT CACTTGTGCA GTGTTGACAG TTCATATGTA CCATGTACAT GAAGAAGCTA 10561 AATCCTTTAC TGTTAGTCAT TTGCTGAGCA TGTACTGAGC CTTGTAATTC TAAATGAATG 10621 TTTACACTCT TTGTAAGAGT GGAACCAACA CTAACATATA ATGTTGTTAT TTAAAGAACA 10681 CCCTATATTT TGCATAGTAC CAATCATTTT AATTATTATT CTTCATAACA ATTTTAGGAG 10741 GACCAGAGCT ACTGACTATG GCTACCAAAA AGACTCTACC CATATTACAG ATGGGCAAAT 10801 TAAGGCATAA GAAAACTAAG AAATATGCAC AATAGCAGTT GAAACAAGAA GCCACAGACC 10861 TAGGATTTCA TGATTTCATT TCAACTGTTT GCCTTCTGCT TTTAAGTTGC TGATGAACTC 10921 TTAATCAAAT AGCATAAGTT TCTGGGACCT CAGTTTTATC ATTTTCAAAA TGGAGGGAAT 10981 AATACCTAAG CCTTCCTGCC GCAACAGTTT TTTATGCTAA TCAGGGAGGT CATTTTGGTA 11041 AAATACTTCT CGAAGCCGAG CCTCAAGATG AAGGCAAAGC ACGAAATGTT ATTTTTTAAT 11101 TATTATTTAT ATATGTATTT ATAAATATAT TTAAGATAAT TATAATATAC TATATTTATG 11161 GGAACCCCTT CATCCTCTGA GTGTGACCAG GCATCCTCCA CAATAGCAGA CAGTGTTTTC 11221 TGGGATAAGT AAGTTTGATT TCATTAATAC AGGGCATTTT GGTCCAAGTT GTGCTTATCC 11281 CATAGCCAGG AAACTCTGCA TTCTAGTACT TGGGAGACCT GTAATCATAT AATAAATGTA 11341 CATTAATTAC CTTGAGCCAG TAATTGGTCC GATCTTTGAC TCTTTTGCCA TTAAACTTAC 11401 CTGGGCATTC TTGTTTCATT CAATTCCACC TGCAATCAAG TCCTACAAGC TAAAATTAGA 11461 TGAACTCAAC TTTGACAACC ATGAGACCAC TGTTATCAAA ACTTTCTTTT CTGGAATGTA 11521 ATCAATGTTT CTTCTAGGTT CTAAAAATTG TGATCAGACC ATAATGTTAC ATTATTATCA 11581 ACAATAGTGA TTGATAGAGT GTTATCAGTC ATAACTAAAT AAAGCTTGCA ACAAAATTCT 11641 CTGACACATA GTTATTCATT GCCTTAATCA TTATTTTACT GCATGGTAAT TAGGGACAAA 11701 TGGTAAATGT TTACATAAAT AATTGTATTT AGTGTTACTT TATAAAATCA AACCAAGATT 11761 TTATATTTTT TTCTCCTCTT TGTTAGCTGC CAGTATGCAT AAATGGCATT AAGAATGATA 11821 ATATTTCCGG GTTCACTTAA AGCTCATATT ACACATACAC AAAACATGTG TTCCCATCTT 11881 TATACAAACT CACACATACA GAGCTACATT AAAAACAACT AATAGGCCAG GCACGGTGGC 11941 TCAGACCTGT AATCCCAGCA CTTTGGGAGG

1 ACCAACCTCT TCGAGGCACA AGGCACAACA GGCTGCTCTG GGATTCTCTT CAGCCAATCT

61 TCATTGCTCA AGTGTCTGAA GCAGCCATGG CAGAAGTACC TGAGCTCGCC AGTGAAATGA

121 TGGCTTATTA CAGTGGCAAT GAGGATGACT TGTTCTTTGA AGCTGATGGC CCTAAACAGA

181 TGAAGTGCTC CTTCCAGGAC CTGGACCTCT GCCCTCTGGA TGGCGGCATC CAGCTACGAA

241 TCTCCGACCA CCACTACAGC AAGGGCTTCA GGCAGGCCGC GTCAGTTGTT GTGGCCATGG

301 ACAAGCTGAG GAAGATGCTG GTTCCCTGCC CACAGACCTT CCAGGAGAAT GACCTGAGCA

361 CCTTCTTTCC CTTCATCTTT GAAGAAGAAC CTATCTTCTT CGACACATGG GATAACGAGG

421 CTTATGTGCA CGATGCACCT GTACGATCAC TGAACTGCAC GCTCCGGGAC TCACAGCAAA

481 AAAGCTTGGT GATGTCTGGT CCATATGAAC TGAAAGCTCT CCACCTCCAG GGACAGGATA

5 1 TGGAGCAACA AGTGGTGTTC TCCATGTCCT TTGTACAAGG AGAAGAAAGT AATGACAAAA

601 TACCTGTGGC CTTGGGCCTC AAGGAAAAGA ATCTGTACCT GTCCTGCGTG TTGAAAGATG

661 ATAAGCCCAC TCTACAGCTG GAGAGTGTAG ATCCCAAAAA TTACCCAAAG AAGAAGATGG

721 AAAAGCGATT TGTCTTCAAC AAGATAGAAA TCAATAACAA GCTGGAATTT GAGTCTGCCC

781 AGTTCCCCAA CTGGTACATC AGCACCTCTC AAGCAGAAAA CATGCCCGTC TTCCTGGGAG

841 GGACCAAAGG CGGCCAGGAT ATAACTGACT TCACCATGCA ATTTGTGTCT TCCTAAAGAG

901 AGCTGTACCC AGAGAGTCCT GTGCTGAATG TGGACTCAAT CCCTAGGGCT GGCAGAAAGG

961 GAACAGAAAG GTTTTTGAGT ACGGCTATAG CCTGGACTTT CCTGTTGTCT ACACCAATGC

1021 CCAACTGCCT GCCTTAGGGT AGTGCTAAGA GGATCTCCTG TCCATCAGCC AGGACAGTCA

1081 GCTCTCTCCT TTCAGGGCCA ATCCCCAGCC CTTTTGTTGA GCCAGGCCTC TCTCACCTCT

1141 CCTACTCACT TAAAGCCCGC CTGACAGAAA CCACGGCCAC ATTTGGTTCT AAGAAACCCT

1201 CTGTCATTCG CTCCCACATT CTGATGAGCA ACCGCTTCCC TATTTATTTA TTTATTTGTT

1261 TGTTTGTTTT ATTCATTGGT CTAATTTATT CAAAGGGGGC AAGAAGTAGC AGTGTCTGTA

1321 AAAGAGCCTA GTTTTTAATA GCTATGGAAT CAATTCAATT TGGACTGGTG TGCTCTCTTT

1381 AAATCAAGTC CTTTAATTAA GACTGAAAAT ATATAAGCTC AGATTATTTA AATGGGAATA

1441 TTTATAAATG AGCAAATATC ATACTGTTCA ATGGTTCTGA AATAAACTTC TCTGAAG

1 AGAAAGAAAG AGAGAGAGAA AGAAAAGAAA GAGGAAGGAA GGAAGGAAGG AAGAAAGACA 61 GGCTCTGAGG AAGGTGGCAG TTCCTACAAC GGGAGAACCA GTGGTTAATT TGCAAAGTGG 121 ATCCTGTGGA GGCANNCAGA GGAGTCCCCT AGGCCACCCA GACAGGGCTT TTAGCTATCT 181 GCAGGCCAGA CACCAAATTT CAGGAGGGCT CAGTGTTAGG AATGGATTAT GGCTTATCAA 241 ATTCACAGGA AACTAACATG TTGAACAGCT TTTAGATTTC CTGTGGAAAA TATAACTTAC 301 TAAAGATGGA GTTCTTGTGA CTGACTCCTG ATATCAAGAT ACTGGGAGCC AAATTAAAAA

361 TCAGAAGGCT GCTTGGAGAG CAAGTCCATG AAATGCTCTT TTTCCCACAG TAGAACCTAT 421 TTCCCTCGTG TCTCAAATAC TTGCACAGAG GCTCACTCCC TTGGATAATG CAGAGCGAGC

481 ACGATACCTG GCACATACTA ATTTGAATAA AATGCTGTCA AATTCCCATT CACCCATTCA 541 AGCAGCAAAC TCTATCTCAC CTGAATGTAC ATGCCAGGCA CTGTGCTAGA CTTGGCTCAA 601 AAAGATTTCA GTTTCCTGGA GGAACCAGGA GGGCAAGGTT TCAACTCAGT GCTATAAGAA EPI-109 681

661 GTGTTACAGG CTGGACACGG TGGCTCACGC CTGTAATCCC AACATTTGGG AGGCCGAGGC 721 GGGCAGATCA CAAGGTCAGG AGATCGAGAC CATCCTGGCT AACATGGTGA AACCCTGTCT 781 CTACTAAAAA TACAAAAAAT TAGCCGGGCG TTGGCGGCAG GTGCCTGTAG TCCCAGCTGC 841 TGGGGAGGCT GAGGCAGGAG AATGGTGTGA ACCCGGGAGG CGGAACTTGC AGGGGGCCGA 901 GATCGTGCCA CTGCACTCCA GCCTGGGCGA CAGAGTGAGA CTCTGTCTCA AAAAAAAAAA 961 AAAAGTGTTA TGATGCAGAC CTGTCAAAGA GGCAAAGGAG GGTGTTCCTA CACTCCAGGC 1021 ACTGTTCATA ACCTGGACTC TCATTCATTC TACAAATGGA GGGCTCCCCT GGGCAGATCC 1081 CTGGAGCAGG CACTTTGCTG GTGTCTCGGT TAAAGAGAAA CTGATAACTC TTGGTATTAC 1141 CAAGAGATAG AGTCTCAGAT GGATATTCTT ACAGAAACAA TATTCCCACT TTTCAGAGTT 1201 CACCAAAAAA TCATTTTAGG CAGAGCTCAT CTGGCATTGA TCTGGTTCAT CCATGAGATT 1261 GGCTAGGGTA ACAGCACCTG GTCTTGCAGG GTTGTGTGAG CTTATCTCCA GGGTTGCCCC 1321 AACTCCGTCA GGAGCCTGAA CCCTGCATAC CGTATGTTCT CTGCCCCAGC CAAGAAAGGT 1381 CAATTTTCTC CTCAGAGGCT CCTGCAATTG ACAGAGAGCT CCCGAGGCAG AGAACAGCAC 1441 CCAAGGTAGA GACCCACACC CTCAATACAG ACAGGGAGGG CTATTGGCCC TTCATTGTAC 1501 CCATTTATCC ATCTGTAAGT GGGAAGATTC CTAAACTTAA GTACAAAGAA GTGAATGAAG 1561 AAAAGTATGT GCATGTATAA ATCTGTGTGT CTTCCACTTT GTCCCACATA TACTAAATTT 1621 AAACATTCTT CTAACGTGGG AAAATCCAGT ATTTTAATGT GGACATCAAC TGCACAACGA 1681 TTGTCAGGAA AACAATGCAT ATTTGCATGG TGATACATTT GCAAAATGTG TCATAGTTTG 1741 CTACTCCTTG CCCTTCCATG AACCAGAGAA TTATCTCAGT TTATTAGTCC CCTCCCCTAA 1801 GAAGCTTCCA CCAATACTC.T TTTCCCCTTT CCTTTAACTT GATTGTGAAA TCAGGTATTC 1861 AACAGAGAAA TTTCTCAGCC TCCTACTTCT GCTTTTGAAA GCTATAAAAA CAGCGAGGGA 1921 GAAACTGGCA GATACCAAAC CTCTTCGAGG CACAAGGCAC AACAGGCTGC TCTGGGATTC 1981 TCTTCAGCCA ATCTTCATTG CTCAAGTATG ACTTTAATCT TCCTTACAAC TAGGTGCTAA 2041 GGGAGTCTCT CTGTCTCTCT GCCTCTTTGT GTGTATGCAT ATTCTCTCTC TCTCTCTCTT 2101 TCTTTCTCTG TCTCTCCTCT CCTTCCTCTC TGCCTCCTCT CTCAGCTTTT TGCAAAAATG 2161 CCAGGTGTAA TATAATGCTT ATGACTCGGG AAATATTCTG GGAATGGATA CTGCTTATCT 2221 AACAGCTGAC ACCCTAAAGG TTAGTGTCAA AGCCTCTGCT CCAGCTCTCC TAGCCAATAC 2281 ATTGCTAGTT GGGGTTTGGT TTAGCAAATG CTTTTCTCTA GACCCAAAGG ACTTCTCTTT 2341 CACACATTCA TTCATTTACT CAGAGATCAT TTCTTTGCAT GACTGCCATG CACTGGATGC 2401 TGAGAGAAAT CACACATGAA CGTAGCCGTC ATGGGGAAGT CACTCATTTT CTCCTTTTTA 2461 CACAGGTGTC TGAAGCAGCC ATGGCAGAAG TACCTGAGCT CGCCAGTGAA ATGATGGCTT 2521 ATTACAGGTC AGTGGAGACG CTGAGACCAG TAACATGAGC AGGTCTCCTC TTTCAAGAGT 2581 AGAGTGTTAT CTGTGCTTGG AGACCAGATT TTTCCCCTAA ATTGCCTCTT TCAGTGGCAA 2641 ACAGGGTGCC AAGTAAATCT GATTTAAAGA CTACTTTCCC ATTACAAGTC CCTCCAGCCT 2701 TGGGACCTGG AGGCTATCCA GATGTGTTGT TGCAAGGGCT TCCTGCAGAG GCAAATGGGG 2761 AGAAAAGATT CCAAGCCCAC AATACAAGGA ATCCCTTTGC AAAGTGTGGC TTGGAGGGAG 2821 AGGGAGAGCT CAGATTTTAG CTGACTCTGC TGGGCTAGAG GTTAGGCCTC AAGATCCAAC 2881 AGGGAGCACC AGGGTGCCCA CCTGCCAGGC CTAGAATCTG CCTTCTGGAC TGTTCTGCGC 2941 ATATCACTGT GAAACTTGCC AGGTGTTTCA GGCAGCTTTG AGAGGCAGGC TGTTTGCAGT 3001 TTCTTATGAA CAGTCAAGTC TTGTACACAG GGAAGGAAAA ATAAACCTGT TTAGAAGACA 3061 TAATTGAGAC ATGTCCCTGT TTTTATTACA GTGGCAATGA GGATGACTTG TTCTTTGAAG 3121 CTGATGGCCC TAAACAGATG AAGGTAAGAC TATGGGTTTA ACTCCCAACC CAAGGAAGGG 3181 CTCTAACACA GGGAAAGCTC AAAGAAGGGA GTTCTGGGCC ACTTTGATGC CATGGTATTT 3241 TGTTTTAGAA AGACTTTAAC CTCTTCCAGT GAGACACAGG CTGCACCACT TGCTGACCTG 3301 GCCACTTGGT CATCATATCA CCACAGTCAC TCACTAACGT TGGTGGTGGT GGCCACACTT 3361 GGTGGTGACA GGGGAGGAGT AGTGATAATG TTCCCATTTC ATAGTAGGAA GACAACCAAG 3421 TCTTCAACAT AAATTTGATT ATCCTTTTAA GAGATGGATT CAGCCTATGC CAATCACTTG 3481 AGTTAAACTC TGAAACCAAG AGATGATCTT GAGAACTAAC ATATGTCTAC CCCTTTTGAG 3541 TAGAATAGTT TTTTGCTACC TGGGGTGAAG CTTATAACAA CAAGACATAG ATGATATAAA 3601 CAAAAAGATG AATTGAGACT TGAAAGAAAA CCATTCACTT GCTGTTTGAC CTTGACAAGT 3661 CATTTTACCC GCTTTGGACC TCATCTGAAA AATAAAGGGC TGAGCTGGAT GATCTCTGAG 3721 ATTCCAGCAT CCTGCAACCT CCAGTTCTGA AATATTTTCA GTTGTAGCTA AGGGCATTTG 3781 GGCAGCAAAT GGTCATTTTT CAGACTCATC CTTACAAAGA GCCATGTTAT ATTCCTGCTG 3841 TCCCTTCTGT TTTATATGAT GCTCAGTAGC CTTCCTAGGT GCCCAGCCAT CAGCCTAGCT 3901 AGGTCAGTTG TGCAGGTTGG AGGCAGCCAC TTTTCTCTGG CTTTATTTTA TTCCAGTTTG 3961 TGATAGCCTC CCCTAGCCTC ATAATCCAGT CCTCAATCTT GTTAAAAACA TATTTCTTTA 4021 GAAGTTTTAA GACTGGCATA ACTTCTTGGC TGCAGCTGTG GGAGGAGCCC ATTGGCTTGT 4081 CTGCCTGGCC TTTGCCCCCC ATTGCCTCTT CCAGCAGCTT GGCTCTGCTC CAGGCAGGAA 4141 ATTCTCTCCT GCTCAACTTT CTTTTGTGCA CTTACAGGTC TCTTTAACTG TCTTTCAAGC 4201 CTTTGAACCA TTATCAGCCT TAAGGCAACC TCAGTGAAGC CTTAATACGG AGCTTCTCTG 4261 AATAAGAGGA AAGTGGTAAC ATTTCACAAA AAGTACTCTC ACAGGATTTG CAGAATGCCT 4321 ATGAGACAGT GTTATGAAAA AGGAAAAAAA AGAACAGTGT AGAAAAATTG AATACTTGCT 4381 GAGTGAGCAT AGGTGAATGG AAAATGTTAT GGTCATCTGC ATGAAAAAGC AAATCATAGT 4441 GTGACAGCAT TAGGGATACA AAAAGATATA GAGAAGGTAT ACATGTATGG TGTAGGTGGG 4501 GCATGTACAA AAAGATGACA AGTAGAATCG GGATTTATTC TAAAGAATAG CCTGTAAGGT 4561 GTCCAGAAGC CACATTCTAG TCTTGAGTCT GCCTCTACCT GCTGTGTGCC CTTGAGTACA 4621 CCCTTAACCT CCTTGAGCTT CAGAGAGGGA TAATCTTTTT ATTTTATTTT ATTTTATTTT 4681 GTTTTGTTTT GTTTTGTTTT GTTTTATGAG ACAGAGTCTC ACTCTGTTGC CCAGGCTGGA EPI-109 682

4741 GTGCAGTGGT ACAATCTTGG CTTACTGCAT CCTCCACCTC CTGAGTTi-AA GCGATTCTCC 4801 TTCCTCAGTC TCCTGAATAG CTAGGATTAC AGGTGCACCC CACCACACCC AGCTAATTTT 4861 TGTATTTTTA GTAGAGAAGG GGTTTCGCCA TGTTGGCCAG GCTGGTTTTG AAGTCCTGAC 4921 CTAAATGATT CATCCACCTC GGCTTCCCAA AGTGCTGGGA TTACAGGCAT GAGCCACCAC 4981 GCCTGGCCCA GAGAGGGATG ATCTTTAGAA GCTCGGGATT CTTTCAAGCC CTTTCCTCCT 5041 CTCTGAGCTT TCTACTCTCT GATGTCAAAG CATGGTTCCT GGCAGGACCA CCTCACCAGG 5101 CTCCCTCCCT CGCTCTCTCC GCAGTGCTCC TTCCAGGACC TGGACCTCTG CCCTCTGGAT 5161 GGCGGCATCC AGCTACGAAT CTCCGACCAC CACTACAGCA AGGGCTTCAG GCAGGCCGCG 5221 TCAGTTGTTG TGGCCATGGA CAAGCTGAGG AAGATGCTGG TTCCCTGCCC ACAGACCTTC 5281 CAGGAGAATG ACCTGAGCAC CTTCTTTCCC TTCATCTTTG AAGAAGGTAG TTAGCCAAGA 5341 GCAGGCAGTA GATCTCCACT TGTGTCCTCT TGGAAGTCAT CAAGCCCCAG CCAACTCAAT 5401 TCCCCCAGAG CCAAAGCCCT TTAAAGGTAG AAGGCCCAGC GGGGAGACAA AACAAAGAAG 5461 GCTGGAAACC AAAGCAATCA TCTCTTTAGT GGAAACTATT CTTAAAGAAG ATCTTGATGG 5521 CTACTGACAT TTGCAACTCC CTCACTCTTT CTCAGGGGCC TTTCACTTAC ATTGTCACCA 5581 GAGGTTCGTA ACCTCCCTGT GGGCTAGTGT TATGACCATC ACCATTTTAC CTAAGTAGCT 5641 CTGTTGCTCG GCCACAGTGA GCAGTAATAG ACCTGAAGCT GGAACCCATG TCTAATAGTG 5701 TCAGGTCCAG TGTTCTTAGC CACCCCACTC CCAGCTTCAT CCCTACTGGT GTTGTCATCA 5761 GACTTTGACC GTATATGCTC AGGTGTCCTC CAAGAAATCA AATTTTGCCA CCTCGCCTCA 5821 CGAGGCCTGC CCTTCTGATT TTATACCTAA ACAACATGTG CTCCACATTT CAGAACCTAT 5881 CTTCTTCGAC ACATGGGATA ACGAGGCTTA TGTGCACGAT GCACCTGTAC GATCACTGAA 5941 CTGCACGCTC CGGGACTCAC AGCAAAAAAG CTTGGTGATG TCTGGTCCAT ATGAACTGAA 6001 AGCTCTCCAC CTCCAGGGAC AGGATATGGA GCAACAAGGT AAATGGAAAC ATCCTGGTTT 6061 CCCTGCCTGG CCTCCTGGCA GCTTGCTAAT TCTCCATGTT TTAAACAAAG TAGAAAGTTA 6121 ATTTAAGGCA AATGATCAAC ACAAGTGAAA AAAAATATTA AAAAGGAATA TACAAACTTT 6181 GGTCCTAGAA ATGGCACATT TGATTGCACT GGCCAGTGCA TTTGTTAACA GGAGTGTGAC 6241 CCTGAGAAAT TAGACGGCTC AAGCACTCCC AGGACCATGT CCACCCAAGT CTCTTGGGCA 6301 TAGTGCAGTG TCAATTCTTC CACAATATGG GGTCATTTGA TGGACATGGC CTAACTGCCT 6361 GTGGGTTCTC TCTTCCTGTT GTTGAGGCTG AAACAAGAGT GCTGGAGCGA TAATGTGTCC 6421 ATCCCCCTCC CCAGTCTTCC CCCCTTGCCC CAACATCCGT CCCACCCAAT GCCAGGTGGT 6481 TCCTTGTAGG GAAATTTTAC CGCCCAGCAG GAACTTATAT CTCTCCGCTG TAACGGGCAA 6541 AAGTTTCAAG TGCGGTGAAC CCATCATTAG CTGTGGTGAT CTGCCTGGCA TCGTGCCACA 6601 GTAGCCAAAG CCTCTGCACA GGAGTGTGGG CAACTAAGGC TGCTGACTTT GAAGGACAGC 6661 CTCACTCAGG GGGAAGCTAT TTGCTCTCAG CCAGGCCAAG AAAATCCTGT TTCTTTGGAA 6721 TCGGGTAGTA AGAGTGATCC CAGGGCCTCC AATTGACACT GCTGTGACTG AGGAAGATCA 6781 AAATGAGTGT CTCTCTTTGG AGCCACTTTC CCAGCTCAGC CTCTCCTCTC CCAGTTTCTT 6841 CCCATGGGCT ACTCTCTGTT CCTGAAACAG TTCTGGTGCC TGATTTCTGG CAGAAGTACA 6901 GCTTCACCTC TTTCCTTTCC TTCCACATTG ATCAAGTTGT TCCGCTCCTG TGGATGGGCA 6961 CATTGCCAGC CAGTGACACA ATGGCTTCCT TCCTTCCTTC CTTCAGCATT TAAAATGTAG 7021 ACCCTCTTTC ATTCTCCGTT CCTACTGCTA TGAGGCTCTG AGAAACCCTC AGGCCTTTGA 7081 GGGGAAACCC TAAATCAACA AAATGACCCT GCTATTGTCT GTGAGAAGTC AAGTTATCCT 7141 GTGTCTTAGG CCAAGGAACC TCACTGTGGG TTCCCACAGA GGCTACCAAT TACATGTATC 7201 CTACTCTCGG GGCTAGGGGT TGGGGTGACC CTGCATGCTG TGTCCCTAAC CACAAGACCC 7261 CCTTCTTTCT TCAGTGGTGT TCTCCATGTC CTTTGTACAA GGAGAAGAAA GTAATGACAA 7321 AATACCTGTG GCCTTGGGCC TCAAGGAAAA GAATCTGTAC CTGTCCTGCG TGTTGAAAGA 7381 TGATAAGCCC ACTCTACAGC TGGAGGTAAG TGAATGCTAT GGAATGAAGC CCTTCTCAGC 7441 CTCCTGCTAC CACTTATTCC CAGACAATTC ACCTTCTCCC CGCCCCCATC CCTAGGAAAA 7501 GCTGGGAACA GGTCTATTTG ACAAGTTTTG CATTAATGTA AATAAATTTA ACATAATTTT 7561 TAACTGCGTG CAACCTTCAA TCCTGCTGCA GAAAATTAAA TCATTTTGCC GATGTTATTA 7621 TGTCCTACCA TAGTTACAAC CCCAACAGAT TATATATTGT TAGGGCTGCT CTCATTTGAT 7681 AGACACCTTG GGAAATAGAT GACTTAAAGG GTCCCATTAT CACGTCCACT CCACTCCCAA 7741 AATCACCACC ACTATCACCT CCAGCTTTCT CAGCAAAAGC TTCATTTCCA AGTTGATGTC 7801 ATTCTAGGAC CATAAGGAAA AATACAATAA AAAGCCCCTG GAAACTAGGT ACTTCAAGAA 7861 GCTCTAGCTT AATTTTCAC.C CCCCCAAAAA AAAAAAATTC TCACCTACAT TATGCTCCTC

7921 AGCATTTGGC ACTAAGTTTT AGAAAAGAAG AAGGGCTCTT TTAATAATCA CACAGAAAGT 7981 TGGGGGCCCA GTTACAACTC AGGAGTCTGG CTCCTGATCA TGTGACCTGC TCGTCAGTTT 8041 CCTTTCTGGC CAACCCAAAG AACATCTTTC CCATAGGCAT CTTTGTCCCT TGCCCCACAA 8101 AAATTCTTCT TTCTCTTTCG CTGCAGAGTG TAGATCCCAA AAATTACCCA AAGAAGAAGA 8161 TGGAAAAGCG ATTTGTCTTC AACAAGATAG AAATCAATAA CAAGCTGGAA TTTGAGTCTG 8221 CCCAGTTCCC CAACTGGTAC ATCAGCACCT CTCAAGCAGA AAACATGCCC GTCTTCCTGG 8281 GAGGGACCAA AGGCGGCCAG GATATAACTG ACTTCACCAT GCAATTTGTG TCTTCCTAAA 8341 GAGAGCTGTA CCCAGAGAGT CCTGTGCTGA ATGTGGACTC AATCCCTAGG GCTGGCAGAA 8401 AGGGAACAGA AAGGTTTTTG AGTACGGCTA TAGCCTGGAC TTTCCTGTTG TCTACACCAA 8461 TGCCCAACTG CCTGCCTTAG GGTAGTGCTA AGAGGATCTC CTGTCCATCA GCCAGGACAG 8521 TCAGCTCTCT CCTTTCAGGG CCAATCCCCA GCCCTTTTGT TGAGCCAGGC CTCTCTCACC 8581 TCTCCTACTC ACTTAAAGCC CGCCTGACAG AAACCACGGC CACATTTGGT TCTAAGAAAC

8641 CCTCTGTCAT TCGCTCCCAC ATTCTGATGA GCAACCGCTT CCCTATTTAT TTATTTATTT 8701 GTTTGTTTGT TTTGATTCAT TGGTCTAATT TATTCAAAGG GGGCAAGAAG TAGCAGTGTC 8761 TGTAAAAGAG CCTAGTTTTT AATAGCTATG GAATCAATTC AATTTGGACT GGTGTGCTCT EPI-109 683

8821 CTTTAAATCA AGTCCTTTAA TTAAGACTGA AAATATATAA GCTCAGATTA TTTAAATGGG 8881 AATATTTATA AATGAGCAAA TATCATACTG TTCAATGGTT CTGAAATAAA CTTCACTGAA 8941 GAAAAAAAAA AAAGGGTCTC TCCTGATCAT TGACTGTCTG GATTGACACT GACAGTAAGC 9001 AAACAGGCTG TGAGAGTTCT TGGGACTAAG CCCACTCCTC ATTGCTGAGT GCTGCAAGTA 9061 CCTAGAAATA TCCTTGGCCA CCGAAGACTA TCCTCCTCAC CCATCCCCTT TATTTCGTTG 9121 TTCAACAGAA GGATATTCAG TGCACATCTG GAACAGGATC AGCTGAAGCA CTGCAGGGAG 9181 TCAGGACTGG TAGTAACAGC TACCATGATT TATCTATCAA TGCACCAAAC ATCTGTTGAG 9241 CAAGCGCTAT GTACTAGGAG CTGGGAGTAC AGAGATGAGA ACAGTCACAA GTCCCTCCTC 9301 AGATAGGAGA GGCAGCTAGT TATAAGCAGA ACAAGGTAAC ATGACAAGTA GAGTAAGATA 9361 GAAGAACGAA GAGGAGTAGC CAGGAAGGAG GGAGGAGAAC GACATAAGAA TCAAGCCTAA 9421 AGGGATAAAC AGAAGATTTC CACACATGGG CTGGGCCAAT TGGGTGTCGG TTACGCCTGT 9481 AATCCCAGCA CTTTGGGTGG CAGGGGCAGA AAGATCGCTT GAGCCCAGGA GTTCAAGACC 9541 AGCCTGGGCA ACATAGTGAG ACTCCCATCT CTACAAAAAA TAAATAAATA AATAAAACAA 9601 TCAGCCAGGC ATGCTGGCAT GCACCTGTAG TCCTAGCTAC TTGGGAAGCT GACACTGGAG 9661 GATTGCTTGA GCCCAGAAGT TCAAGACTGC AGTGAGCTTA TCCGTTGACC TGCAGGTCGA 9721 C

1 ACAAACCTTT TCGAGGCAAA AGGCAAAAAA GGCTGCTCTG GGATTCTCTT CAGCCAATCT

61 TCAATGCTCA AGTGTCTGAA GCAGCCATGG CAGAAGTACC TAAGCTCGCC AGTGAAATGA

121 TGGCTTATTA CAGTGGCAAT GAGGATGACT TGTTCTTTGA AGCTGATGGC CCTAAACAGA

181 TGAAGTGCTC CTTCCAGGAC CTGGACCTCT GCCCTCTGGA TGGCGGCATC CAGCTACGAA

241 TCTCCGACCA CCACTACAGC AAGGGCTTCA GGCAGGCCGC GTCAGTTGTT GTGGCCATGG

301 ACAAGCTGAG GAAGATGCTG GTTCCCTGCC CACAGACCTT CCAGGAGAAT GACCTGAGCA

361 CCTTCTTTCC CTTCATCTTT GAAGAAGAAC CTATCTTCTT CGACACATGG GATAACGAGG

421 CTTATGTGCA CGATGCACCT GTACGATCAC TGAACTGCAC GCTCCGGGAC TCACAGCAAA

481 AAAGCTTGGT GATGTCTGGT CCATATGAAC TGAAAGCTCT CCACCTCCAG GGACAGGATA

541 TGGAGCAACA AGTGGTGTTC TCCATGTCCT TTGTACAAGG AGAAGAAAGT AATGACAAAA

601 TACCTGTGGC CTTGGGCCTC AAGGAAAAGA ATCTGTACCT GTCCTGCGTG TTGAAAGATG

661 ATAAGCCCAC TCTACAGCTG GAGAGTGTAG ATCCCAAAAA TTACCCAAAG AAGAAGATGG

721 AAAAGCGATT TGTCTTCAAC AAGATAGAAA TCAATAACAA GCTGGAATTT GAGTCTGCCC

781 AGTTCCCCAA CTGGTACATC AGCACCTCTC AAGCAGAAAA CATGCCCGTC TTCCTGGGAG

841 GGACCAAAGG CGGCCAGGAT ATAACTGACT TCACCATGCA ATTTGTGTCT TCCTAAAGAG

901 AGCTGTACCC AGAGAGTCCT GTGCTGAATG TGGACTCAAT CCCTAGGGCT GGCAGAAAGG

961 GAACAGAAAG GTTTTTGAGT ACGGCTATAG CCTGGACTTT CCTGTTGTCT ACACCAATGC

1021 CCAACTGCCT GCCTTAGGGT AGTGCTAAGA GGATCTCCTG TCCATCAGCC AGGACAGTCA

1081 GCTCTCTCCT TTCAGGGCCA ATCCCAGCCC TTTTGTTGAG CCAGGCCTCT CTCACCTCTC

1141 CTACTCACTT AAAGCCCGCC TGACAGAAAC CAGGCCACAT TTTGGTTCTA AGAAACCCTC

1201 CTCTGTCATT CGCTCCCACA TTCTGATGAG CAACCGCTTC CCTATTTATT TATTTATTTG

1261 TTTGTTTGTT TTGATTCATT GGTCTAATTT ATTCAAAGGG GGCAAGAAGT AGCAGTGTCT

1321 GTAAAAGAGC CTAGTTTTTA ATAGCTATGG AATCAATTCA ATTTGGACTG GTGTGCTCTC

1381 TTTAAATCAA GTCCTTTAAT TAAGACTGAA AATATATAAG CTCAGATTAT TTAAATGGGA

1441 ATATTTATAA ATGAGCAAAT ATCATACTGT TCAATGGTTC TCAAATAAAC TTCACT

1 CTGGCAGGAG TAGCAGCTGC CCCTTGGCGC GACTGCTGGA GCCGCGAACT AGAGAAACAC 61 AGACACGCCT CATAGAGCAA CGGCGTCTCT CGGAGCGTGG AGCCCGCCAA GCTCGAGCTG 121 AGCTTTCGCT TGCCGTCCAC CACTGCCCAC ACTGTCGTTT GCTGCCATCG CAGACCTGCT 181 GCTGACTTCC ATCCCTCTGG ATCCGGCAAG GGCCTGCGAT TTTGACAATG TCAAGATTTA 241 CCGTATATCC CTGTTTGTTT GGATACACCA GTGACGTCCA CTTCTAGAAG ACAAAGTTAT 301 ATTACTTAAA CAACCAAAGA TATGAAACTA TCCATGAAGA ACAATATTAT CAATACACAG 361 CAGTCTTTTG TAACCATGCC CAATGTGATT GTACCAGATA TTGAAAAGGA AATACGAAGG 421 ATGGAAAATG GAGCATGCAG CTCCTTTTCT GAGGATGATG ACAGTGCCTC TACATCTGAA 481 GAATCAGAGA ATGAAAACCC TCATGCAAGG GGTTCCTTTA GTTATAAGTC ACTCAGAAAG 541 GGAGGACCAT CACAGAGGGA GCAGTACCTG CCTGGTGCCA TTGCCATTTT TAATGTGAAC 601 AACAGCGACA ATAAGGACCA GGAACCAGAA GAAAAAAAGA AAAAGAAAAA AGAAAAGAAG 661 AGCAAGTCAG ATGATAAAAA CGAAAATAAA AACGACCCAA AGAAGAAGAT GGAAAAGCGA 1 ATGGCCAAAG TTCCAGACAT GTTTGAAGAC CTGAAGAACT GTTACAGTGA AAATGAAGAA 61 GACAGTTCCT CCATTGATCA TCTGTCTCTG AATCAGAAAT CCTTCTATCA TGTAAGCTAT 121 GGCCCACTCC ATGAAGGCTG CATGGATCAA TCTGTGTCTC TGAGTATCTC TGAAACCTCT 181 AAAACATCCA AGCTTACCTT CAAGGAGAGC ATGGTGGTAG TAGCAACCAA CGGGAAGGTT 241 CTGAAGAAGA GACGGTTGAG TTTAAGCCAA TCCATCACTG ATGATGACCT GGAGGCCATC 301 GCCAATGACT CAGAGGAAGA AATCATCAAG CCTAGGTCAG CACCTTTTAG CTTCCTGAGC 361 AATGTGAAAT ACAACTTTAT GAGGATCATC AAATACGAAT TCATCCTGAA TGACGCCCTC 421 AATCAAAGTA TAATTCGAGC CAATGATCAG TACCTCACGG CTGCTGCATT ACATAATCTG 481 GATGAAGCAG TGAAATTTGA CATGGGTGCT TATAAGTCAT CAAAGGATGA TGCTAAAATT 541 ACCGTGATTC TAAGAATCTC AAAAACTCAA TTGTATGTGA CTGCCCAAGA TGAAGACCAA 601 CCAGTGCTGC TGAAGGAGAT GCCTGAGATA CCCAAAACCA TCACAGGTAG TGAGACCAAC 661 CTCCTCTTCT TCTGGGAAAC TCACGGCACT AAGAACTATT TCACATCAGT TGCCCATCCA 721 AACTTGTTTA TTGCCACAAA GCAAGACTAC TGGGTGTGCT TGGCAGGGGG GCCACCCTCT 781 ATCACTGACT TTCAGATACT GGAAAACCAG GCGTAGGTCT GGAGTCTCAC TTGTCTCACT 841 TGTGCAGTGT TGACAGTTCA TATGTACCAT GTACATGAAG AAGCTAAATC CTTTACTGTT EPI-109 684

901 AGTCATTTGC TGAGCATGTA CTGAGCCTTG TAATTCTAAA TGAATGTTTA CACTCTTTGT

961 AAGAGTGGAA CCAACACTAA CATATAATGT TGTTATTTAA AGAACACCCT ATATTTTGCA

1021 TAGTACCAAT CATTTTAATT ATTATTCTTC ATAACAATTT TAGGAGGACC AGAGCTACTG

1081 ACTATGGCTA CCAAAAAGAC TCTACCCATA TTACAGATGG GCAAATTAAG GCATAAGAAA

1141 ACTAAGAAAT ATGCACAATA GCAGTTGAAA CAAGAAGCCA CAGACCTAGG ATTTCATGAT

1201 TTCATTTCAA CTGTTTGCCT TCTGCTTTTA AGTTGCTGAT GAACTCTTAA TCAAATAGCA

1261 TAAGTTTCTG GGACCTCAGT TTTATCATTT TCAAAATGGA GGGAATAATA CCTAAGCCTT

1321 CCTGCCGCAA CAGTTTTTTA TGCTAATCAG GGAGGTCATT TTGGTAAAAT ACTTCTCGAA

1381 GCCGAGCCTC AAGATGAAGG CAAAGCACGA AATGTTATTT TTTAATTATT ATTTATATAT

1441 GTATTTATAA ATATATTTAA GATAATTATA ATATACTATA TTTATGGGAA CCCCTTCATC

1501 CTCTGAGTGT GACCAGGCAT CCTCCACAAT AGCAGACAGT GTTTTCTGGG ATAAGTAAGT

1561 TTGATTTCAT TAATACAGGG CATTTTGGTC CAAGTTGTGC TTATCCCATA GCCAGGAAAC

1621 TCTGCATTCT AGTACTTGGG AGACCTGTAA TCATATAATA AATGTACATT AATTACCTTG

1681 AGCCAGTAAT TGGTCCGATC TTTGACTCTT TTGCCATTAA ACTTACCTGG GCATTCTTGT

1741 TTCATTCAAT TCCACCTGCA ATCAAGTCCT ACAAGCTAAA ATTAGATGAA CTCAACTTTG 1801 ACAACCATAG ACCACTGTTA TCAAAACTTT CTTTTCTGGA ATGTAATCAA TGTTTCTTCT

1861 AGGTTCTAAA AATTGTGATC AGACCATAAT GTTACATTAT TATCAACAAT AGTGATTGAT 1921 AGAGTGTTAT CAGTCATAAC TAAATAAAGC TTGCAAGTGA GGGAGTCATT TCATTGGCGT 1981 TTGAGTCAGC AAAGAAGTCA AG

1 AGCTGCCAGC CAGAGAGGGA GTCATTTCAT TGGCGTTTGA GTCAGCAAAG AAGTCAAGAT

61 GGCCAAAGTT CCAGACATGT TTGAAGACCT GAAGAACTGT TACAGTGAAA ATGAAGAAGA

121 CAGTTCCTCC ATTGATCATC TGTCTCTGAA TCAGAAATCC TTCTATCATG TAAGCTATGG

181 CCCACTCCAT GAAGGCTGCA TGGATCAATC TGTGTCTCTG AGTATCTCTG AAACCTCTAA

241 AACATCCAAG CTTACCTTCA AGGAGAGCAT GGTGGTAGTA GCAACCAACG GGAAGGTTCT

301 GAAGAAGAGA CGGTTGAGTT TAAGCCAATC CATCACTGAT GATGACCTGG AGGCCATCGC

361 CAATGACTCA GAGGAAGAAA TCATCAAGCC TAGGTCATCA CCTTTTAGCT TCCTGAGCAA

421 TGTGAAATAC AACTTTATGA GGATCATCAA ATACGAATTC ATCCTGAATG ACGCCCTCAA

481 TCAAAGTATA ATTCGAGCCA ATGATCAGTA CCTCACGGCT GCTGCATTAC ATAATCTGGA

541 TGAAGCAGTG AAATTTGACA TGGGTGCTTA TAAGTCATCA AAGGATGATG CTAAAATTAC

601 CGTGATTCTA AGAATCTCAA AAACTCAATT GTATGTGACT GCCCAAGATG AAGACCAACC

661 AGTGCTGCTG AAGGAGATGC CTGAGATACC CAAAACCATC ACAGGTAGTG AGACCAACCT

721 CCTCTTCTTC TGGGAAACTC ACGGCACTAA GAACTATTTC ACATCAGTTG CCCATCCAAA

781 CTTGTTTATT GCCACAAAGC AAGACTACTG GGTGTGCTTG GCAGGGGGGC CACCCTCTAT

841 CACTGACTTT CAGATACTGG AAAACCAGGC GTAGGTCTGG AGTCTCACTT GTCTCACTTG

901 TGCAGTGTTG ACAGTTCATA TGTACCATGT ACATGAAGAA GCTAAATCCT TTACTGTTAG

961 TCATTTGCTG AGCATGTACT GAGCCTTGTA ATTCTAAATG AATGTTTACA CTCTTTGTAA

1021 GAGTGGAACC AACACTAACA TATAATGTTG TTATTTAAAG AACACCCTAT ATTTTGCATA

1081 GTACCAATCA TTTTAATTAT TATTCTTCAT AACAATTTTA GGAGGACCAG AGCTACTGAC

1141 TATGGCTACC AAAAAGACTC TACCCATATT ACAGATGGGC AAATTAAGGC ATAAGAAAAC

1201 TAAGAAATAT GCACAATAGC AGTCGAAACA AGAAGCCACA GACCTAGGAT TTCATGATTT

1261 CATTTCAACT GTTTGCCTTC TGCTTTTAAG TTGCTGATGA ACTCTTAATC AAATAGCATA

1321 AGTTTCTGGG ACCTCAGTTT TATCATTTTC AAAATGGAGG GAATAATACC TAAGCCTTCC

1381 TGCCGCAACA GTTTTTTATG CTAATCAGGG AGGTCATTTT GGTAAAATAC TTCTCGAAGC

1441 CGAGCCTCAA GATGAAGGCA AAGCACGAAA TGTTATTTTT TAATTATTAT TTATATATGT

1501 ATTTATAAAT ATATTTAAGA TAATTATAAT ATACTATATT TATGGGAACC CCTTCATCCT

1561 CTGAGTGTGA CCAGGCATCC TCCACAATAG CAGACAGTGT TTTCTGGGAT AAGTAAGTTT

1621 GATTTCATTA ATACAGGGCA TTTTGGTCCA AGTTGTGCTT ATCCCATAGC CAGGAAACTC

1681 TGCATTCTAG TACTTGGGAG ACCTGTAATC ATATAATAAA TGTACATTAA TTACCTTGAG

1741 CCAGTAATTG GTCCGATCTT TGACTCTTTT GCCATTAAAC TTACCTGGGC ATTCTTGTTT

1801 CATTCAATTC CACCTGCAAT CAAGTCCTAC AAGCTAAAAT TAGATGAACT CAACTTTGAC

1861 AACCATGAGA CCACTGTTAT CAAAACTTTC TTTTCTGGAA TGTAATCAAT GTTTCTTCTA

1921 GGTTCTAAAA ATTGTGATCA GACCATAATG TTACATTATT ATCAACAATA GTGATTGATA

1981 GAGTGTTATC AGTCATAACT AAATAAAGCT TGCAACAAAA TTCTCTG

( 2 ) INFORMATION FOR SEQ ID NO : 2518 : ( l ) SEQUENCE CHARACTERISTICS :

(A) LENGTH : 1308 base pairs

(B) TYPE : nucleic acid

( C) STRANDEDNESS : single

( D) TOPOLOGY : linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2518:

1 GCCACGTGCT GCTGGGTCTC AGTCCTCCAC TTCCCGTGTC CTCTGGAAGT TGTCAGGAGC 61 AATGTTGCGC TTGTACGTGT TGGTAATGGG AGTTTCTGCC TTCACCCTTC AGCCTGCGGC 121 ACACACAGGG GCTGCCAGAA GCTGCCGGTT TCGTGGGAGG CATTACAAGC GGGAGTTCAG 181 GCTGGAAGGG GAGCCTGTAG CCCTGAGGTG CCCCCAGGTG CCCTACTGGT TGTGGGCCTC 241 TGTCAGCCCC CGCATCAACC TGACATGGCA TAAAAATGAC TCTGCTAGGA CGGTCCCAGG 301 AGAAGAAGAG ACACGGATGT GGGCCCAGGA CGGTGCTCTG TGGCTTCTGC CAGCCTTGCA 361 GGAGGACTCT GGCACCTACG TCTGCACTAC TAGAAATGCT TCTTACTGTG ACAAAATGTC 421 CATTGAGCTC AGAGTTTTTG AGAATACAGA TGCTTTCCTG CCGTTCATCT CATACCCGCA EPI-109 685

481 AATTTTAACC TTGTCAACCT CTGGGGTATT AGTATGCCCT GACCTGAGTG AATTCACCCG

541 TGACAAAACT GACGTGAAGA TTCAATGGTA CAAGGATTCT CTTCTTTTGG ATAAAGACAA

601 TGAGAAATTT CTAAGTGTGA GGGGGACCAC TCACTTACTC GTACACGATG TGGCCCTGGA

661 AGATGCTGGC TATTACCGCT GTGTCCTGAC ATTTGCCCAT GAAGGGCAGC AATACAACAT

721 CACTAGGAGT ATTGAGCTAC GCATCAAGAA AAAAAAAGAA GAGACCATTC CTGTGATCAT

781 TTCCCCCCTC AAGACCATAT CAGCTTCTCT GGGGTCAAGA CTGACAATCC CGTGTAAGGT

841 GTTTCTGGGA ACCGGCACAC CCTTAACCAC CATGCTGTGG TGGACGGCCA ATGACACCCA

901 CATAGAGAGC GCCTACCCGG GAGGCCGCGT GACCGAGGGG CCACGCCAGG AATATTCAGA

961 AAATAATGAG AACTACATTG AAGTGCCATT GATTTTTGAT CCTGTCACAA GAGAGGATTT

1021 GCACATGGAT TTTAAATGTG TTGTCCATAA TACCCTGAGT TTTCAGACAC TACGCACCAC

1081 AGTCAAGGAA GCCTCCTCCA CGTTCTCCTG GGGCATTGTG CTGGCCCCAC TTTCACTGGC

1141 CTTCTTGGTT TTGGGGGGAA TATGGATGCA CAGACGGTGC AAACACAGAA CTGGAAAAGC

1201 AGATGGTCTG ACTGTGCTAT GGCCTCATCA TCAAGACTTT CAATCCTATC CCAAGTGAAA

1261 TAAATGGAAT GAAATAATTC AAACACAAAA AAAAAAAAAA AAAAAAAA

(2) INFORMATION FOR SEQ ID NO: 2519: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2156 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2519:

1 GCCGGAGCCG ACTCGGAGCG CGCGGCGCGG CCGGGAGGAG CCGAGCGCGC CGGGCGCGGC 61 GTGGGGGCGC CGGCTGCCCC GCGCGCCCAG GGAGCGGCAG GAATGTGACA ATCGCGCGCC 121 CGCACCGTAG CACTCCTCGG TCGGCTCCTA GGGCTCTCGC CCTCTGAGCT GAGCCGGGTT 181 CCGCCCGGGC TGGGATCCCA TCACCCTCCA CGGCCGTCCG TCCAGGTAGA CGCACCCTCT 241 GAAGATGGTG ACTCCCTCCT GAGAAGCTGG ACCCCTTGGT AAAAGACAAG GCCTTCTCCA 301 AGAAGAATAT GAAAGTGTTA CTCAGACTTA TTTGTTTCAT AGCTCTACTG ATTTCTTCTC

361 TGGAGGCTGA TAAATGCAAG GAACGTGAAG AAAAAATAAT TTTAGTGTCA TCTGCAAATG 421 AAATTGATGT TCGTCCCTGT CCTCTTAACC CAAATGAACA CAAAGGCACT ATAACTTGGT

481 ATAAAGATGA CAGCAAGACA CCTGTATCTA CAGAACAAGC CTCCAGGATT CATCAACACA 541 AAGAGAAACT TTGGTTTGTT CCTGCTAAGG TGGAGGATTC AGGACATTAC TATTGCGTGG 601 TAAGAAATTC ATCTTACTGC CTCAGAATTA AAATAAGTGC AAAATTTGTG GAGAATGAGC 661 CTAACTTATG TTATAATGCA CAAGCCATAT TTAAGCAGAA ACTACCCGTT GCAGGAGACG 721 GAGGACTTGT GTGCCCTTAT ATGGAGTTTT TTAAAAATGA AAATAATGAG TTACCTAAAT 781 TACAGTGGTA TAAGGATTGC AAACCTCTAC TTCTTGACAA TATACACTTT AGTGGAGTCA 841 AAGATAGGCT CATCGTGATG AATGTGGCTG AAAAGCATAG AGGGAACTAT ACTTGTCATG 901 CATCCTACAC ATACTTGGGC AAGCAATATC CTATTACCCG GGTAATAGAA TTTATTACTC 961 TAGAGGAAAA CAAACCCACA AGGCCTGTGA TTGTGAGCCC AGCTAATGAG ACAATGGAAG

1021-TAGACTTGGG ATCCCAGATA CAATTGATCT GTAATGTCAC CGGCCAGTTG AGTGACATTG 1081 CTTACTGGAA GTGGAATGGG TCAGTAATTG ATGAAGATGA CCCAGTGCTA GGGGAAGACT 1141 ATTACAGTGT GGAAAATCCT GCAAACAAAA GAAGGAGTAC CCTCATCACA GTGCTTAATA 1201 TATCGGAAAT TGAAAGTAGA TTTTATAAAC ATCCATTTAC CTGTTTTGCC AAGAATACAC 1261 ATGGTATAGA TGCAGCATAT ATCCAGTTAA TATATCCAGT CACTAATTTC CAGAAGCACA 1321 TGATTGGTAT ATGTGTCACG TTGACAGTCA TAATTGTGTG TTCTGTTTTC ATCTATAAAA 1381 TCTTCAAGAT TGACATTGTG CTTTGGTACA GGGATTCCTG CTATGATTTT CTCCCAATAA 14 1 AAGCTTCAGA TGGAAAGACC TATGACGCAT ATATACTGTA TCCAAAGACT GTTGGGGAAG 1501 GGTCTACCTC TGACTGTGAT ATTTTTGTGT TTAAAGTCTT GCCTGAGGTC TTGGAAAAAC 1561 AGTGTGGATA TAAGCTGTTC ATTTATGGAA GGGATGACTA CGTTGGGGAA GACATTGTTG 1621 AGGTCATTAA TGAAAACGTA AAGAAAAGCA GAAGACTGAT TATCATTTTA GTCAGAGAAA 1681 CATCAGGCTT CAGCTGGCT^'G GGTGGTTCAT CTGAAGAGCA AATAGCCATG TATAATGCTC 1741 TTGTTCAGGA TGGAATTAAA GTTGTCCTGC TTGAGCTGGA GAAAATCCAA GACTATGAGA 1801 AAATGCCAGA ATCGATTAAA TTCATTAAGC AGAAACATGG GGCTATCCGC TGGTCAGGGG 1861 ACTTTACACA GGGACCACAG TCTGCAAAGA CAAGGTTCTG GAAGAATGTC AGGTACCACA 1921 TGCCAGTCCA GCGACGGTCA CCTTCATCTA AACACCAGTT ACTGTCACCA GCCACTAAGG 1981 AGAAACTGCA AAGAGAGGCT CACGTGCCTC TCGGGTAGCA TGGAGAAGTT GCCAAGAGTT 2041 CTTTAGGTGC CTCCTGTCTT ATGGCGTTGC AGGCCAGGTT ATGCCTCATG CTGACTTGCA 2101 GAGTTCATGG AATGTAACTA TATCATCCTT TATCCCTGAG GTCACCAGGA ATCAGG

(2) INFORMATION FOR SEQ ID NO:2520: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3464 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2520:

1 GCCACGTGCT GCTGGGTCTC AGTCCTCCAC TTCCCGTGTC CTCTGGAAGT TGTCAGGAGC

61 AATGTTGCGC TTGTACGTGT TGGTAATGGG AGTTTCTGCC TTCACCCTTC AGCCTGCGGC

121 ACACACAGGG GCTGCCAGAA GCTGCCGGTT TCGTGGGAGG CATTACAAGC GGGAGTTCAG EPI-109 686

181 GCTGGAAGGG GAGCCTGTAG CCCTGAGGTG CCCCCAGGTG CCCTACTGGT TGTGGGCCTC

241 TGTCAGCCCC CGCATCAACC TGACATGGCA TAAAAATGAC TCTGCTAGGA CGGTCCCAGG

301 AGAAGAAGAG ACACGGATGT GGGCCCAGGA CGGTGCTCTG TGGCTTCTGC CAGCCTTGCA

361 GGAGGACTCT GGCACCTACG TCTGCACTAC TAGAAATGCT TCTTACTGTG ACAAAATGTC

421 CATTGAGCTC AGAGTTTTTG AGAATACAGA TGCTTTCCTG CCGTTCATCT CATACCCGCA

481 AATTTTAACC TTGTCAACCT CTGGGGTATT AGTATGCCCT GACCTGAGTG AATTCACCCG

541 TGACAAAACT GACGTGAAGA TTCAATGGTA CAAGGATTCT CTTCTTTTGG ATAAAGACAA

601 TGAGAAATTT CTAAGTGTGA GGGGGACCAC TCACTTACTC GTACACGATG TGGCCCTGGA

661 AGATGCTGGC TATTACCGCT GTGTCCTGAC ATTTGCCCAT GAAGGCCAGC AATACAACAT

721 CACTAGGAGT ATTGAGCTAC GCATCAAGAA AAAAAAAGAA GAGACCATTC CTGTGATCAT

781 TTCCCCCCTC AAGACCATAT CAGCTTCTCT GGGGTCAAGA CTGACAATCC CGTGTAAGGT

841 GTTTCTGGGA ACCGGCACAC CCTTAACCAC CATGCTGTGG TGGACGGCCA ATGACACCCA

901 CATAGAGAGC GCCTACCCGG GAGGCCGCGT GACCGAGGGG CCACGCCAGG AATATTCAGA

961 AAATAATGAG AACTACATTG AAGTGCCATT GATTTTTGAT CCTGTCACAA GAGAGGATTT

1021 GCACATGGAT TTTAAATGTG TTGTCCATAA TACCCTGAGT TTTCAGACAC TACGCACCAC

1081 AGTCAAGGAA GCCTCCTCCA CGTTCTCCTG GGGCATTGTG CTGGCCCCAC TTTCACTGGC

1141 CTTCTTGGTT TTGGGGGGAA TATGGATGCA CAGACGGTGC AAACACAGAA CTGGAAAAGC

1201 AGATGGTCTG ACTGTGCTAT GGCCTCATCA TCAAGACTTT CAATCCTATC CCAAGTGAAA

1261 TAAATGGAAT GAAATAATTC AAACACAAAA AAAAAAAAAA AAAAAAAA

1 GCCGGAGCCG ACTCGGAGCG CGCGGCGCGG CCGGGAGGAG CCGAGCGCGC CGGGCGCGGC

61 GTGGGGGCGC CGGCTGCCCC GCGCGCCCAG GGAGCGGCAG GAATGTGACA ATCGCGCGCC

121 CGCACCGTAG CACTCCTCGC TCGGCTCCTA GGGCTCTCGC CCTCTGAGCT GAGCCGGGTT

181 CCGCCCGGGC TGGGATCCCA TCACCCTCCA CGGCCGTCCG TCCAGGTAGA CGCACCCTCT

241 GAAGATGGTG ACTCCCTCCT GAGAAGCTGG ACCCCTTGGT AAAAGACAAG GCCTTCTCCA

301 AGAAGAATAT GAAAGTGTTA CTCAGACTTA TTTGTTTCAT AGCTCTACTG ATTTCTTCTC

361 TGGAGGCTGA TAAATGCAAG GAACGTGAAG AAAAAATAAT TTTAGTGTCA TCTGCAAATG

421 AAATTGATGT TCGTCCCTGT CCTCTTAACC CAAATGAACA CAAAGGCACT ATAACTTGGT

481 ATAAAGATGA CAGCAAGACA CCTGTATCTA CAGAACAAGC CTCCAGGATT CATCAACACA

541 AAGAGAAACT TTGGTTTGTT CCTGCTAAGG TGGAGGATTC AGGACATTAC TATTGCGTGG

601 TAAGAAATTC ATCTTACTGC CTCAGAATTA AAATAAGTGC AAAATTTGTG GAGAATGAGC

661 CTAACTTATG TTATAATGCA CAAGCCATAT TTAAGCAGAA ACTACCCGTT GCAGGAGACG

721 GAGGACTTGT GTGCCCTTAT ATGGAGTTTT TTAAAAATGA AAATAATGAG TTACCTAAAT

781 TACAGTGGTA TAAGGATTGC AAACCTCTAC TTCTTGACAA TATACACTTT AGTGGAGTCA

841 AAGATAGGCT CATCGTGATG AATGTGGCTG AAAAGCATAG AGGGAACTAT ACTTGTCATG

901 CATCCTACAC ATACTTGGGC AAGCAATATC CTATTACCCG GGTAATAGAA TTTATTACTC

961 TAGAGGAAAA CAAACCCACA AGGCCTGTGA TTGTGAGCCC AGCTAATGAG ACAATGGAAG

1021 TAGACTTGGG ATCCCAGATA CAATTGATCT GTAATGTCAC CGGCCAGTTG AGTGACATTG

1081 CTTACTGGAA GTGGAATGGG TCAGTAATTG ATGAAGATGA CCCAGTGCTA GGGGAAGACT

1141 ATTACAGTGT GGAAAATCCT GCAAACAAAA GAAGGAGTAC CCTCATCACA GTGCTTAATA

1201 TATCGGAAAT TGAAAGTAGA TTTTATAAAC ATCCATTTAC CTGTTTTGCC AAGAATACAC

1261 ATGGTATAGA TGCAGCATAT ATCCAGTTAA TATATCCAGT CACTAATTTC CAGAAGCACA

1321 TGATTGGTAT ATGTGTCACG TTGACAGTCA TAATTGTGTG TTCTGTTTTC ATCTATAAAA

1381 TCTTCAAGAT TGACATTGTG CTTTGGTACA GGGATTCCTG CTATGATTTT CTCCCAATAA

1441 AAGCTTCAGA TGGAAAGACC TATGACGCAT ATATACTGTA TCCAAAGACT GTTGGGGAAG

1501 GGTCTACCTC TGACTGTGAT ATTTTTGTGT TTAAAGTCTT GCCTGAGGTC TTGGAAAAAC

1561 AGTGTGGATA TAAGCTGTTC ATTTATGGAA GGGATGACTA CGTTGGGGAA GACATTGTTG

1621 AGGTCATTAA TGAAAACGTA AAGAAAAGCA GAAGACTGAT TATCATTTTA GTCAGAGAAA

1681 CATCAGGCTT CAGCTGGCTG GGTGGTTCAT CTGAAGAGCA AATAGCCATG TATAATGCTC

1741 TTGTTCAGGA TGGAATTAAA GTTGTCCTGC TTGAGCTGGA GAAAATCCAA GACTATGAGA

1801 AAATGCCAGA ATCGATTAAA TTCATTAAGC AGAAACATGG GGCTATCCGC TGGTCAGGGG

1861 ACTTTACACA GGGACCACAG TCTGCAAAGA CAAGGTTCTG GAAGAATGTC AGGTACCACA

1921 TGCCAGTCCA GCGACGGTCA CCTTCATCTA AACACCAGTT ACTGTCACCA GCCACTAAGG

1981 AGAAACTGCA AAGAGAGGCT CACGTGCCTC TCGGGTAGCA TGGAGAAGTT GCCAAGAGTT

2041 CTTTAGGTGC CTCCTGTCTT ATGGCGTTGC AGGCCAGGTT ATGCCTCATG CTGACTTGCA

2101 GAGTTCATGG AATGTAACTA TATCATCCTT TATCCCTGAG GTCACCAGGA ATCAGG

(2) INFORMATION FOR SEQ ID NO: 2521: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1185 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 2521 :

1 GCTCAGGGCA CATGCCTCCC CTCCCCAGGC CGCGGCCCAG CTGACCCTCG GGGCTCCCCC 61 GGCAGCGGAC AGGGAAGGGT TAAAGGCCCC CGGCTCCCTG CCCCCTGCCC TGGGGAACCC 121 CTGGCCCTGT GGGGACATGA ACTGTGTTTG CCGCCTGGTC CTGGTCGTGC TGAGCCTGTG 181 GCCAGATACA GCTGTCGCCC CTGGGCCACC ACCTGGCCCC CCTCGAGTTT CCCCAGACCC 241 TCGGGCCGAG CTGGACAGCA CCGTGCTCCT GACCCGCTCT CTCCTGGCGG ACACGCGGCA 301 GCTGGCTGCA CAGCTGAGGG ACAAATTCCC AGCTGACGGG GACCACAACC TGGATTCCCT EPI-109 687

361 GCCCACCCTG GCCATGAGTG CGGGGGCACT GGGAGCTCTA CAGCTCCCAG GTGTGCTGAC 421 AAGGCTGCGA GCGGACCTAC TGTCCTACCT GCGGCACGTG CAGTGGCTGC GCCGGGCAGG

481 TGGCTCTTCC CTGAAGACCC TGGAGCCCGA GCTGGGCACC CTGCAGGCCC GACTGGACCG 541 GCTGCTGCGC CGGCTGCAGC TCCTGATGTC CCGCCTGGCC CTGCCCCAGC CACCCCCGGA 601 CCCGCCGGCG CCCCCGCTGG CGCCCCCCTC CTCAGCCTGG GGGGGCATCA GGGCCGCCCA 661 CGCCATCCTG CGGGGGCTGC ACCTGACACT TGACTGGGCC GTGAGGGGAC TGCTGCTGCT 721 GAAGACTCGG CTGTGACCCG GGGCCCAAAG CCACCACCGT CCTTCCAAAG CCAGATCTTA 781 TTTATTTATT TATTTCAGTA CTGGGGGCGA AACAGCCAGG TGATCCCCCC GCCATTATCT 841 CCCCCTAGTT AGAGACAGTC CTTCCGTGAG GCCTGGGGGA CATCTGTGCC TTATTTATAC 901 TTATTTATTT CAGGAGCAGG GGTGGGAGGC AGGTGGACTC CTGGGTCCCC GAGGAGGAGG 961 GGACTGGGGT CCCGGATTCT TGGGTCTCCA AGAAGTCTGT CCACAGACTT CTGCCCTGGC

1021 TCTTCCCCAT CTAGGCCTGG GCAGGAACAT ATATTATTTA TTTAAGCAAT TACTTTTCAT 1081 GTTGGGGTGG GGACGGAGGG GAAAGGGAAG CCTGGGTTTT TGTACAAAAA TGTGAGAAAC 1141 CTTTGTGAGA CAGAGAACAG GGAATTAAAT GTGTCATACA TATCC

(2) INFORMATION FOR SEQ ID NO: 2522: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 6870 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2522:

1 CAGCTGCGGC ATCCTCTGTC TCAGAGTCTT GGTGTCTCTG TTCCTTTCCC CTCGGGGTCT

61 CCCTGGGTCT CCCCAAGTCC CTCCTGCTGT CTTCCTCCCG CTCTCTGATC TCTGACTCCC

121 AGAACCTCTC CCTCTGTCTC CAGGGCTGCC CCTCTGATCC TCTTTGCTTC TCTGGTGTGT

181 CTCTCTGGCT GCCTCCATCT CTGTGGATCT CCGTCTCCCT GTCTCTGTCT CAGTCTGTCC

241 TTCACTCTGT GTGTGTGTGT GTCTCTCTCT CTCTCTCTCC TTCCCTTCCA CTCCCTCTTC

301 CTCCTGCCTC CACCTCTCCA GGCCCCTGTC TTGTCCCTCC GTCCGGCCTT TCTCTGCCTT

361 TCCGTCCTCC TGCCTCCCCA TCTCTCTCTG CTAGTCCTGT CCAGCCGGAC CCCCACCCAC

421 AGTCGGGCCC CAGCGCTTGA GCCTGAGTGT CTGCTCCGGC CCGTGGAGGT GGAGGGAGGG

481 GACGCCAATG ACCTCACCAG CCCCTCTCCG ACCACCCCCC CCTTTCCCTT TTCAACTTTT

541 CCAACTTTTC CTTCCGTGCC CTCCTCCGAG CGCGGCGGCG TGAGCCCTGC AAGGCAGCCG

601 CTCCGTCTGA ATGGAAAAGG CAGGCAGGGA GGGTGAGTCA GGATGTGTCA GGCCGGCCCT

661 CCCCTGCCGC CTGCCCCCCG CCCGCCCGCC CCAGGCCCCC TATATAACCC CCCAGGCGTC

721 CACACTCCCT CACTGCCGCG GGCCCTGCTG CTCAGGGCAC ATGCCTCCCC TCCCCAGCCG

781 CGGGCCCAGC TGACCCTCGG GGCTCCCCCG GCAGCGGACA GGGAAGGGTT AAAGGCCCCC

841 GGCTCCCTGC CCCCTGCCCT GGGGAACCCC TGGCCCTGTG GGGACATGAA CTGTAAGTTG

901 GTTCATGGGG AGGGTGGAGG GGACAGGGAG GCAGGGAGGA GAGGGACCCA CGGCGGGGGT

961 GGGAGCAGAC CCCGCTGAGT CGCACAGAGA GGGACCCGGA GACAGGCAGC CGGGGAGGAG

1021 AGCAGCTTCG GAGACAGGAG GCGGCGGAGG AGATGGGCAG AGAGAGACAC AGACAGGAGC

1081 GGATGGAGGC AGCCAATCAG AGGCGCCGCA GGAGGGACGG GCCAGACAGG GCCCGAGAGG

1141 AGCGAGACGC GAGACCGAGC AGGGGCAGGG ACGCAGGGAC TGGTGCCGGG AGGGAGGTGA

1201 CCCCCATCGA CCCAGGCCCC AGGGAGCCCG CGGGGACCGG GAGACTCCCT GGGATTCCGG

1261 CAGAGAGGCT CCGGAGGGAA ACTGAGGCAG GGTCCGCGGA GAGCGGAGCA AGCCAGGGAG

1321 TAGCGACCCC AGCCGGGGGG AGGAGAGAGA CTGGGCGCCG GGGGAAAGCG GGGAGAGCCG

1381 GGCAGATGCG GCCGACGGAG GCGCGGACAG ACCGACGGCT GGCGGGCCCG GGGGGCGGGC

1441 TGGGGGTGTG CGAGGCGCGG GCGGCCGGGG AGCGCTGATT GGCTGGCGGG TGGCCGGGTG

1501 GGCGGGGCGG CCGGGGTGGG CTGCGGGGAG CGAGCTCCGG ACCCCCGCGC CCCCGGCGCC

1561 CCCCGCGCCC CCCGCCGCCA GCTCTCCCGC TCCCGGCGCC CGGCCGGGCC ATGGCTCTGC

1621 CCCTCTCCGC CCAGGTGCGC TGCGGCCCGG GCTTCTGCCG CCCACCCGGC GGGCTCCTGG

1681 GAGGGCGTCT AAGGGGTCTC CCGTGGGAGA GGTCCGTGTC TCCCGGACTC CGTCCTGGGC

1741 TTTTGGCTCC TTCCCCTGCT CCCAGCCAGC TCGGGCTCCC GCGGCCCGGG GAGGGGGCAG

1801 GTTCTGGCCT GTGCCTCCCC CACCATCCGC GCCCCGGGGC CCAGATTCCG GCGTCCGGGG

1861 GCGGACGGGA GACGCCCGGG CCGCGTCTGC TCCGACGGGC GGGGCAGCCA GAGCCAGGGA

1921 GGGAGAGGGA AGCCCGCCTG GCCCTGCGAC CTGCCCGCGG GCGTTCCACC CTGGGACTTA

1981 AGACCTCCAG CTCCATCCTC CCTAAGGCCG GGAGTCCAGG CCCCAGACCC TCCTCCCCGA

2041 GACCCAGGAG TCCAGACCCC AGGCCTTCCT CCCTCAGACC TAGGAGTCCA GGCCCCCAGC

2101 CTCTCCTCCC TCAGACCCAG GAGGAGTCCA GACCCCAGTT CCTCCTCCCT CAGACCCGGG

2161 AGTCCAGCCC AGGCCCTCCT CTCTCAGACC CGGAGTCCAG CCTGAGCTCT CTGCCTTATC

2221 CTGCCCCCAG GTGTTTGCCG CCTGGTCCTG GTCGTGCTGA GCCTGTGGCC AGATACAGCT

2281 GTCGCCCCTG GGCCACCACC TGGCCCCCCT CGAGTTTCCC CAGACCCTCG GGCCGAGCTG

2341 GACAGCACCG TGCTCCTGAC CCGCTCTCTC CTGGCGGACA CGCGGCAGCT GGCTGCACAG

2401 CTGGTAGGAG AGACTGGGCT GGGGCCAGCA CAGGAGTGAG AGGCAGAGAG GAACGGAGAG

2461 GAGTCTGCGG GCAGCCACTT GGAGGGGTTC TGGGCTCTCA GGTGGCAGAG TGAGGGAGGG

2521 GAAGAGTTGG GGGCCTGGCG TGGGGGATGG AGGGAGCCCC GAGGCTGGGC AGGGGCCACC

2581 TCACAGCTTT TTTCCCTGCC AGAGGGACAA ATTCCCAGCT GACGGGGACC ACAACCTGGA

2641 TTCCCTGCCC ACCCTGGCCA TGAGTGCAGG GGCACTGGGA GCTCTACAGG TAAGGGCAAG

2701 GGAGTGGGCT GGGGACAAGG TGGGAGGCAG GCAGTGAAGG GGGCGGGGAG GATGAGGGGC

2761 ACTGGTCGGG TGTTCTCTGA TGTCCCGGCT CTATCCCCAG CTCCCAGGTG TGCTGACAAG EPI-109 688

2821 GCTGCGAGCG GACCTACTGT CCTACCTGCG GCACGTGCAG TGGCTGCGCC GGGCAGGTGG 2881 CTCTTCCCTG AAGACCCTGG AGCCCGAGCT GGGCACCCTG CAGGCCCGAC TGGACCGGCT 2941 GCTGCGCCGG CTGCAGCTCC TGGTATGTCC TGGCCCCAAG ACCTGACACC CCAGACCCCC 3001 ACCCCTGGCC CCAAAATCCT GTGGCCTGAG TCCTTGAAGC CTGAGACCCC AGACCCGAGT 3061 GCAACAGCCC CGCTCTGAGA CCCTGACACC CTAACAGCCC GCTCTGAGAC CCTGACACCG 3121 TAACAGCCCC GCTCTGAGAC CCTGACCCTA ACAGTCCTGC TCTGAGACCC TGACCCTGCA 3181 GTCCCAAGAT CCTGTGGCCC TGAGACCCTG AGGCCCTAGA CCCCCAAATC CTGCCCAGAA 3241 ACTTCAAATT CTCACCCAAG ACCCTGAGAC TCCATCATCC ATGACCTCAA AGTCCCCAGA 3301 TCCCAGCCCC TAAGACCCAA GACCCCATCC TGAAGCCCAA AGCCTTGAGA ATTCAAATCC 3361 TCACCTCAAG ACTTGGAGAC CCTGGCCCCA TGACATTGAA AACCATGGAC CTGGCCAGGC 3421 GTGGTGGCTC ACGCCTGTAA TCCCAGCACT TTGGGAGGCC GAGGCAAGTG GATCACCTGA 3481 GGTCGGGAGT TCAAGACCAG CCAGACCAAC ATGGTGAAAC CCTGTCTCTA CTAAAAATAC 3541 AAAATTAGCC AGGCGTGGTG GTGCATGCCT GTAATCCCAG CTACTTGGGA GGCTGAGGCA 3601 GGAGAATCGC TTGAACCTGG GAGGCGGAGG TTGCAGTGAG CCGAGATCGC ACCATTACAC 3661 TCCAGCCTGG GCAACAAGAG CAAAACTCCC TCTCTCTCAA AAAAAAAAAA AAAAAAAAAA 3721 AAGAAGGAAA AGAAAACCAT GGACCTCCAG ACCCTGAGAC CCCAGGCCCC AGCCCTGAGA 3781 TCCTGACATC TTAAAGATCC CAGGCCCTAA GATACAAGAC CTTGACCCAA AGCCAGCCTT 3841 GGGACCCTGG CTGTACAAAC CCAAGACCTC CAGGACCTAG ACCCCGAGCC CTGAGGCCCT 3901 ATGTCTCACT CCCAACATCG AAAACCCTGA CACCTCAGAT CCTGAGCCTG CGCCTGTACG 3961 ACTCCAAGAC CCTCACTTCC AAAGCCAGGC CCAAAGCCCT GAGACCAGAA GACTTCAAAC 4021 CCTGGTTCTT GGGCCTAACT CCAAAGACCC TGGATCTCAA ATTCCAACTT CTAGCTCTGA 4081 GACTCCAGCC CTCACCCATG AGTTCCTGAA CTTGAACCCA GAGACCCCAT CTCTAAGACT 4141 TCAGCCTTGA GATCCAGGGC CTGACCCTAG ACTCGAGCCC ACAGACCTCA GATACTGTCT 4201 GTAAAACCCC AGCTCTGGTG GGGAGCAGTG GCTCACTCCT GTAATCCCAA GGCAGGGGAG 4261 GCCAAGGCAG AAGGACCTCT TGAGGCCATG AGTTTGAGAC AGCCTGGGCA GCATAGCAAG 4321 ACTCTGTTTC TTAATTATTA TTATTATTAT TATTTTTTGG AGACAGAGTC TCGCGCTCTG 4381 TTGCCCAGGC TAGAGTGCAA TGGTGCCATT TCGGCTTGCT GGAACCTCCG CCTCCTGGGC 4441 TCAAGCGATT CTCCTGCCTC AGCCTCCTGA GTAGCTGGGA CTTCAGGTGC ACACTGCCAC 4501 ACCCGGATAA TTTTTTTGTA TTTTAGTAGA CACAGGGTTT CACCGTGTTG CCCAGGCTGG 4561 TCACAAACTC CTGAGCTCAG GCCATCCGCC CGCCTCGGCC TCCCAAAGCG CTGGGATAAC 4621 AGGCGTGACG CCGCGCCTGG CTTCTTAATT GTTCTAACAG CAGCGACAAC AACAAAAACC 4681 CAGCTCTGAG ATTCCAGCCC CGGCGACTCT AACAGTCCCA GGCCCGATCC CTCACCTAGA 4741 ACCGAGATGC CAGCCCTGAC TCCACAGACT TCACCCCCAA CCCCCACACT CAGCTCTGGA 4801 AGCCCGTCCT GACTCCAGCC TCCATTTTCG GAACCCCACA GCCTGAAGAG CTCCCGGCCT 4861 AAACACTTCA CCCCACGCGC CACAGTCCCC CTGTGAATAT GCAGCCCCGA TTCAGCTGCA 4921 GCTCCACAGC ACCCCTGCCC TGCACCCCCG CTGCACCCCC TACCTGTGAC TCACCTCTCT 4981 CCTCTCCCCA CAGATGTCCC GCCTGGCCCT GCCCCAGCCA CCCCCGGACC CGCCGGCGCC 5041 CCCGCTGGCG CCCCCCTCCT CAGCCTGGGG GGGCATCAGG GCCGCCCACG CCATCCTGGG 5101 GGGGCTGCAC CTGACACTTG ACTGGGCCGT GAGGGGACTG CTGCTGCTGA AGACTCGGCT 5161 GTGACCCGGG GCCCAAAGCC ACCACCGTCC TTCCAAAGCC AGATCTTATT TATTTATTTA 5221 TTTCAGTACT GGGGGCGAAA CAGCCAGGTG ATCCCCCCGC CATTATCTCC CCCTAGTTAG 5281 AGACAGTCCT TCCGTGAGGC CTGGGGGGCA TCTGTGCCTT ATTTATACTT ATTTATTTCA 5341 GGAGCAGGGG TGGGAGGCAG GTGGACTCCT GGGTCCCCGA GGAGGAGGGG ACTGGGGTCC 5401 CGGATTCTTG GGTCTCCAAG AAGTCTGTCC ACAGACTTCT GCCCTGGCTC TTCCCCATCT 5461 AGGCCTGGGC AGGAACATAT ATTATTTATT TAAGCAATTA CTTTTCATGT TGGGGTGGGG 5521 ACGGAGGGGA AAGGGAAGCC TGGGTTTTTG TACAAAAATG TGAGAAACCT TTGTGAGACA 5581 GAGAACAGGG AATTAAATGT GTCATACATA TCCACTTGAG GGCGATTTGT CTGAGAGCTG 5641 GGGCTGGATG CTTGGGTAAC TGGGGCAGGG CAGGTGGAGG GGAGACCTCC ATTCAGGTGG 5701 AGGTCCCGAG TGGGCGGGGC AGCGACTGGG AGATGGGTCG GTCACCCAGA CAGCTCTGTG 5761 GAGGCAGGGT CTGAGCCTTG CCTGGGGCCC CGCACTGCAT AGGGCCGTTT GTTTGTTTTT 5821 TGAGATGGAG TCTCGCTCTG TTGCCTAGGC TGGAGTGCAG TGAGGCAATC TAAGGTCACT 5881 GCAACCTCCA CCTCCCGGGT TCAAGCAATT CTCCTGCCTC AGCCTCCCGA TTAGCTGGGA 5941 TCACAGGTGT GCACCACCAT GCCCAGCTAA TTATTTATTT CTTTTGTATT TTTAGTAGAG 6001 ACAGGGTTTC ACCATGTTGG CCAGGCTGGT TTCGAACTCC TGACCTCAGG TGATCCTCCT 6061 GCCTCGGCCT CCCAAAGTGC TGGGATTACA GGTGTGAGCC ACCACACCTG ACCCATAGGT 6121 CTTCAATAAA TATTTAATGG AAGGTTCCAC AAGTCACCCT GTGATCAACA GTACCCGTAT 6181 GGGACAAAGC TGCAAGGTCA AGATGGTTCA TTATGGCTGT GTTCACCATA GCAAACTGGA 6241 AACAATCTAG ATATCCAACA GTGAGGGTTA AGCAACATGG TGCATCTGTG GATAGAACGC 6301 CACCCAGCCG CCCGGAGCAG GGACTGTCAT TCAGGGAGGC TAAGGAGAGA GGCTTGCTTG 6361 GGATATAGAA AGATATCCTG ACATTGGCCA GGCATGGTGG CTCACGCCTG TAATCCTGGC 6421 ACTTTGGGAG GACGAAGCGA GTGGATCACT GAAGTCCAAG AGTTTGAGAC CGGCCTGCGA 6481 GACATGGCAA AACCCTGTCT CAAAAAAGAA AGAATGATGT CCTGACATGA AACAGCAGGC 6541 TACAAAACCA CTGCATGCTG TGATCCCAAT TTTGTGTTTT TCTTTCTATA TATGGATTAA 6601 AACAAAAATC CTAAAGGGAA ATACGCCAAA ATGTTGACAA TGACTGTCTC CAGGTCAAAG 6661 GAGAGAGGTG GGATTGTGGG TGACTTTTAA TGTGTATGAT TGTCTGTATT TTACAGAATT 6721 TCTGCCATGA CTGTGTATTT TGCATGACAC ATTTTAAAAA TAATAAACAC TATTTTTAGA

6781 ATAACAGAAT ATCAGCCTCC TCCTCTCCAA AAATAAGCCC TCAGGAGGGG ACAAAGTTGA

6841 CCGCTGATTG AGCCTGTCAG GGCTGTGCAC EPI-109 689

(2) INFORMATION FOR SEQ ID NO:2523: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 8055 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi)SEQUENCE DESCRIPTION: SEQ ID NO:2523:

1 GCTCAGGGCA CATGCCTCCC CTCCCCAGGC CGCGGCCCAG CTGACCCTCG GGGCTCCCCC

61 GGCAGCGGAC AGGGAAGGGT TAAAGGCCCC CGGCTCCCTG CCCCCTGCCC TGGGGAACCC

121 CTGGCCCTGT GGGGACATGA ACTGTGTTTG CCGCCTGGTC CTGGTCGTGC TGAGCCTGTG

181 GCCAGATACA GCTGTCGCCC CTGGGCCACC ACCTGGCCCC CCTCGAGTTT CCCCAGACCC

241 TCGGGCCGAG CTGGACAGCA CCGTGCTCCT GACCCGCTCT CTCCTGGCGG ACACGCGGCA

301 GCTGGCTGCA CAGCTGAGGG ACAAATTCCC AGCTGACGGG GACCACAACC TGGATTCCCT

361 GCCCACCCTG GCCATGAGTG CGGGGGCACT GGGAGCTCTA CAGCTCCCAG GTGTGCTGAC

421 AAGGCTGCGA GCGGACCTAC TGTCCTACCT GCGGCACGTG CAGTGGCTGC GCCGGGCAGG

481 TGGCTCTTCC CTGAAGACCC TGGAGCCCGA GCTGGGCACC CTGCAGGCCC GACTGGACCG

541 GCTGCTGCGC CGGCTGCAGC TCCTGATGTC CCGCCTGGCC CTGCCCCAGC CACCCCCGGA

601 CCCGCCGGCG CCCCCGCTGG CGCCCCCCTC CTCAGCCTGG GGGGGCATCA GGGCCGCCCA

661 CGCCATCCTG GGGGGGCTGC ACCTGACACT TGACTGGGCC GTGAGGGGAC TGCTGCTGCT

721 GAAGACTCGG CTGTGACCCG GGGCCCAAAG CCACCACCGT CCTTCCAAAG CCAGATCTTA

781 TTTATTTATT TATTTCAGTA CTGGGGGCGA AACAGCCAGG TGATCCCCCC GCCATTATCT

841 CCCCCTAGTT AGAGACAGTC CTTCCGTGAG GCCTGGGGGA CATCTGTGCC TTATTTATAC

901 TTATTTATTT CAGGAGCAGG GGTGGGAGGC AGGTGGACTC CTGGGTCCCC GAGGAGGAGG

961 GGACTGGGGT CCCGGATTCT TGGGTCTCCA AGAAGTCTGT CCACAGACTT CTGCCCTGGC

1021 TCTTCCCCAT CTAGGCCTGG GCAGGAACAT ATATTATTTA TTTAAGCAAT TACTTTTCAT

1081 GTTGGGGTGG GGACGGAGGG GAAAGGGAAG CCTGGGTTTT TGTACAAAAA TGTGAGAAAC

1141 CTTTGTGAGA CAGAGAACAG GGAATTAAAT GTGTCATACA TATCC

1 CAGCTGCGGC ATCCTCTGTC TCAGAGTCTT GGTGTCTCTG TTCCTTTCCC CTCGGGGTCT

61 CCCTGGGTCT CCCCAAGTCC CTCCTGCTGT CTTCCTCCCG CTCTCTGATC TCTGACTCCC

121 AGAACCTCTC CCTCTGTCTC CAGGGCTGCC CCTCTGATCC TCTTTGCTTC TCTGGTGTGT

181 CTCTCTGGCT GCCTCCATCT CTGTGGATCT CCGTCTCCCT GTCTCTGTCT CAGTCTGTCC

241 TTCACTCTGT GTGTGTGTGT GTCTCTCTCT CTCTCTCTCC TTCCCTTCCA CTCCCTCTTC

301 CTCCTGCCTC CACCTCTCCA GGCCCCTGTC TTGTCCCTCC GTCCGGCCTT TCTCTGCCTT

361 TCCGTCCTCC TGCCTCCCCA TCTCTCTCTG CTAGTCCTGT CCAGCCGGAC CCCCACCCAC

421 AGTCGGGCCC CAGCGCTTGA GCCTGAGTGT CTGCTCCGGC CCGTGGAGGT GGAGGGAGGG

481 GACGCCAATG ACCTCACCAG CCCCTCTCCG ACCACCCCCC CCTTTCCCTT TTCAACTTTT

541 CCAACTTTTC CTTCCGTGCC CTCCTCCGAG CGCGGCGGCG TGAGCCCTGC AAGGCAGCCG

601 CTCCGTCTGA ATGGAAAAGG CAGGCAGGGA GGGTGAGTCA GGATGTGTCA GGCCGGCCCT

661 CCCCTGCCGC CTGCCCCCCG CCCGCCCGCC CCAGGCCCCC TATATAACCC CCCAGGCGTC

721 CACACTCCCT CACTGCCGCG GGCCCTGCTG CTCAGGGCAC ATGCCTCCCC TCCCCAGCCG

781 CGGGCCCAGC TGACCCTCGG GGCTCCCCCG GCAGCGGACA GGGAAGGGTT AAAGGCCCCC

841 GGCTCCCTGC CCCCTGCCCT GGGGAACCCC TGGCCCTGTG GGGACATGAA CTGTAAGTTG

901 GTTCATGGGG AGGGTGGAGG GGACAGGGAG GCAGGGAGGA GAGGGACCCA CGGCGGGGGT

961 GGGAGCAGAC CCCGCTGAGT CGCACAGAGA GGGACCCGGA GACAGGCAGC CGGGGAGGAG

1021 AGCAGCTTCG GAGACAGGAG GCGGCGGAGG AGATGGGCAG AGAGAGACAC AGACAGGAGC

1081 GGATGGAGGC AGCCAATCAG AGGCGCCGCA GGAGGGACGG GCCAGACAGG GCCCGAGAGG

1141 AGCGAGACGC GAGACCGAGC AGGGGCAGGG ACGCAGGGAC TGGTGCCGGG AGGGAGGTGA

1201 CCCCCATCGA CCCAGGCCCC AGGGAGCCCG CGGGGACCGG GAGACTCCCT GGGATTCCGG

1261 CAGAGAGGCT CCGGAGGGAA ACTGAGGCAG GGTCCGCGGA GAGCGGAGCA AGCCAGGGAG

1321 TAGCGACCCC AGCCGGGGGG AGGAGAGAGA CTGGGCGCCG GGGGAAAGCG GGGAGAGCCG

1381 GGCAGATGCG GCCGACGGAG GCGCGGACAG ACCGACGGCT GGCGGGCCCG GGGGGCGGGC

1441 TGGGGGTGTG CGAGGCGCGG GCGGCCGGGG AGCGCTGATT GGCTGGCGGG TGGCCGGGTG

1501 GGCGGGGCGG CCGGGGTGGG CTGCGGGGAG CGAGCTCCGG ACCCCCGCGC CCCCGGCGCC

1561 CCCCGCGCCC CCCGCCGCCA GCTCTCCCGC TCCCGGCGCC CGGCCGGGCC ATGGCTCTGC

1621 CCCTCTCCGC CCAGGTGCGC TGCGGCCCGG GCTTCTGCCG CCCACCCGGC GGGCTCCTGG

1681 GAGGGCGTCT AAGGGGTCTC CCGTGGGAGA GGTCCGTGTC TCCCGGACTC CGTCCTGGGC

1741 TTTTGGCTCC TTCCCCTGCT CCCAGCCAGC TCGGGCTCCC GCGGCCCGGG GAGGGGGCAG

1801 GTTCTGGCCT GTGCCTCCCC CACCATCCGC GCCCCGGGGC CCAGATTCCG GCGTCCGGGG

1861 GCGGACGGGA GACGCCCGGG CCGCGTCTGC TCCGACGGGC GGGGCAGCCA GAGCCAGGGA

1921 GGGAGAGGGA AGCCCGCCTG GCCCTGCGAC CTGCCCGCGG GCGTTCCACC CTGGGACTTA

1981 AGACCTCCAG CTCCATCCTC CCTAAGGCCG GGAGTCCAGG CCCCAGACCC TCCTCCCCGA

2041 GACCCAGGAG TCCAGACCCC AGGCCTTCCT CCCTCAGACC TAGGAGTCCA GGCCCCCAGC

2101 CTCTCCTCCC TCAGACCCAG GAGGAGTCCA GACCCCAGTT CCTCCTCCCT CAGACCCGGG

2161 AGTCCAGCCC AGGCCCTCCT CTCTCAGACC CGGAGTCCAG CCTGAGCTCT CTGCCTTATC

2221 CTGCCCCCAG GTGTTTGCCG CCTGGTCCTG GTCGTGCTGA GCCTGTGGCC AGATACAGCT

2281 GTCGCCCCTG GGCCACCACC TGGCCCCCCT CGAGTTTCCC CAGACCCTCG GGCCGAGCTG

2341 GACAGCACCG TGCTCCTGAC CCGCTCTCTC CTGGCGGACA CGCGGCAGCT GGCTGCACAG

2401 CTGGTAGGAG AGACTGGGCT GGGGCCAGCA CAGGAGTGAG AGGCAGAGAG GAACGGAGAG EPI-109 690

2461 GAGTCTGCGG GCAGCCACTT GGAGGGGTTC TGGGCTCTCA GGTGGCAGAG TGAGGGAGGG 2521 GAAGAGTTGG GGGCCTGGCG TGGGGGATGG AGGGAGCCCC GAGGCTGGGC AGGGGCCACC 2581 TCACAGCTTT TTTCCCTGCC AGAGGGACAA ATTCCCAGCT GACGGGGACC ACAACCTGGA 2641 TTCCCTGCCC ACCCTGGCCA TGAGTGCAGG GGCACTGGGA GCTCTACAGG TAAGGGCAAG 2701 GGAGTGGGCT GGGGACAAGG TGGGAGGCAG GCAGTGAAGG GGGCGGGGAG GATGAGGGGC 2761 ACTGGTCGGG TGTTCTCTGA TGTCCCGGCT CTATCCCCAG CTCCCAGGTG TGCTGACAAG 2821 GCTGCGAGCG GACCTACTGT CCTACCTGCG GCACGTGCAG TGGCTGCGCC GGGCAGGTGG 2881 CTCTTCCCTG AAGACCCTGG AGCCCGAGCT GGGCACCCTG CAGGCCCGAC TGGACCGGCT 2941 GCTGCGCCGG CTGCAGCTCC TGGTATGTCC TGGCCCCAAG ACCTGACACC CCAGACCCCC 3001 ACCCCTGGCC CCAAAATCCT GTGGCCTGAG TCCTTGAAGC CTGAGACCCC AGACCCGAGT 3061 GCAACAGCCC CGCTCTGAGA CCCTGACACC CTAACAGCCC GCTCTGAGAC CCTGACACCG 3121 TAACAGCCCC GCTCTGAGAC CCTGACCCTA ACAGTCCTGC TCTGAGACCC TGACCCTGCA 3181 GTCCCAAGAT CCTGTGGCCC TGAGACCCTG AGGCCCTAGA CCCCCAAATC CTGCCCAGAA 3241 ACTTCAAATT CTCACCCAAG ACCCTGAGAC TCCATCATCC ATGACCTCAA AGTCCCCAGA 3301 TCCCAGCCCC TAAGACCCAA GACCCCATCC TGAAGCCCAA AGCCTTGAGA ATTCAAATCC 3361 TCACCTCAAG ACTTGGAGAC CCTGGCCCCA TGACATTGAA AACCATGGAC CTGGCCAGGC 3421 GTGGTGGCTC ACGCCTGTAA TCCCAGCACT TTGGGAGGCC GAGGCAAGTG GATCACCTGA 3481 GGTCGGGAGT TCAAGACCAG CCAGACCAAC ATGGTGAAAC CCTGTCTCTA CTAAAAATAC 3541 AAAATTAGCC AGGCGTGGTG GTGCATGCCT GTAATCCCAG CTACTTGGGA GGCTGAGGCA 3601 GGAGAATCGC TTGAACCTGG GAGGCGGAGG TTGCAGTGAG CCGAGATCGC ACCATTACAC 3661 TCCAGCCTGG GCAACAAGAG CAAAACTCCC TCTCTCTCAA AAAAAAAAAA AAAAAAAAAA 3721 AAGAAGGAAA AGAAAACCAT GGACCTCCAG ACCCTGAGAC CCCAGGCCCC AGCCCTGAGA 3781 TCCTGACATC TTAAAGATCC CAGGCCCTAA GATACAAGAC CTTGACCCAA AGCCAGCCTT 3841 GGGACCCTGG CTGTACAAAC CCAAGACCTC CAGGACCTAG ACCCCGAGCC CTGAGGCCCT 3901 ATGTCTCACT CCCAACATCG AAAACCCTGA CACCTCAGAT CCTGAGCCTG CGCCTGTACG 3961 ACTCCAAGAC CCTCACTTCC AAAGCCAGGC CCAAAGCCCT GAGACCAGAA GACTTCAAAC 4021 CCTGGTTCTT GGGCCTAACT CCAAAGACCC TGGATCTCAA ATTCCAACTT CTAGCTCTGA 4081 GACTCCAGCC CTCACCCATG AGTTCCTGAA CTTGAACCCA GAGACCCCAT CTCTAAGACT 4141 TCAGCCTTGA GATCCAGGGC CTGACCCTAG ACTCGAGCCC ACAGACCTCA GATACTGTCT 4201 GTAAAACCCC AGCTCTGGTG GGGAGCAGTG GCTCACTCCT GTAATCCCAA GGCAGGGGAG 4261 GCCAAGGCAG AAGGACCTCT TGAGGCCATG AGTTTGAGAC AGCCTGGGCA GCATAGCAAG 4321 ACTCTGTTTC TTAATTATTA TTATTATTAT TATTTTTTGG AGACAGAGTC TCGCGCTCTG 4381 TTGCCCAGGC TAGAGTGCAA TGGTGCCATT TCGGCTTGCT GGAACCTCCG CCTCCTGGGC 4441 TCAAGCGATT CTCCTGCCTC AGCCTCCTGA GTAGCTGGGA CTTCAGGTGC ACACTGCCAC 4501 ACCCGGATAA TTTTTTTGTA TTTTAGTAGA CACAGGGTTT CACCGTGTTG CCCAGGCTGG 4561 TCACAAACTC CTGAGCTCAG GCCATCCGCC CGCCTCGGCC TCCCAAAGCG CTGGGATAAC 4621 AGGCGTGACG CCGCGCCTGG CTTCTTAATT GTTCTAACAG CAGCGACAAC AACAAAAACC 4681 CAGCTCTGAG ATTCCAGCCC CGGCGACTCT AACAGTCCCA GGCCCGATCC CTCACCTAGA 4741 ACCGAGATGC CAGCCCTGAC TCCACAGACT TCACCCCCAA CCCCCACACT CAGCTCTGGA 4801 AGCCCGTCCT GACTCCAGCC TCCATTTTCG GAACCCCACA GCCTGAAGAG CTCCCGGCCT 4861 AAACACTTCA CCCCACGCGC CACAGTCCCC CTGTGAATAT GCAGCCCCGA TTCAGCTGCA 4921 GCTCCACAGC ACCCCTGCCC TGCACCCCCG CTGCACCCCC TACCTGTGAC TCACCTCTCT 4981 CCTCTCCCCA CAGATGTCCC GCCTGGCCCT GCCCCAGCCA CCCCCGGACC CGCCGGCGCC 5041 CCCGCTGGCG CCCCCCTCCT CAGCCTGGGG GGGCATCAGG GCCGCCCACG CCATCCTGGG 5101 GGGGCTGCAC CTGACACTTG ACTGGGCCGT GAGGGGACTG CTGCTGCTGA AGACTCGGCT 5161 GTGACCCGGG GCCCAAAGCC ACCACCGTCC TTCCAAAGCC AGATCTTATT TATTTATTTA 5221 TTTCAGTACT GGGGGCGAAA CAGCCAGGTG ATCCCCCCGC CATTATCTCC CCCTAGTTAG 5281 AGACAGTCCT TCCGTGAGGC CTGGGGGGCA TCTGTGCCTT ATTTATACTT ATTTATTTCA 5341 GGAGCAGGGG TGGGAGGCAG GTGGACTCCT GGGTCCCCGA GGAGGAGGGG ACTGGGGTCC 5401 CGGATTCTTG GGTCTCCAAG AAGTCTGTCC ACAGACTTCT GCCCTGGCTC TTCCCCATCT 5461 AGGCCTGGGC AGGAACATAT ATTATTTATT TAAGCAATTA CTTTTCATGT TGGGGTGGGG 5521 ACGGAGGGGA AAGGGAAGCC TGGGTTTTTG TACAAAAATG TGAGAAACCT TTGTGAGACA 5581 GAGAACAGGG AATTAAATGT GTCATACATA TCCACTTGAG GGCGATTTGT CTGAGAGCTG 5641 GGGCTGGATG CTTGGGTAAC TGGGGCAGGG CAGGTGGAGG GGAGACCTCC ATTCAGGTGG 5701 AGGTCCCGAG TGGGCGGGGC AGCGACTGGG AGATGGGTCG GTCACCCAGA CAGCTCTGTG 5761 GAGGCAGGGT CTGAGCCTTG CCTGGGGCCC CGCACTGCAT AGGGCCGTTT GTTTGTTTTT 5821 TGAGATGGAG TCTCGCTCTG TTGCCTAGGC TGGAGTGCAG TGAGGCAATC TAAGGTCACT 5881 GCAACCTCCA CCTCCCGGGT TCAAGCAATT CTCCTGCCTC AGCCTCCCGA TTAGCTGGGA 5941 TCACAGGTGT GCACCACCAT GCCCAGCTAA TTATTTATTT CTTTTGTATT TTTAGTAGAG 6001 ACAGGGTTTC ACCATGTTGG CCAGGCTGGT TTCGAACTCC TGACCTCAGG TGATCCTCCT 6061 GCCTCGGCCT CCCAAAGTGC TGGGATTACA GGTGTGAGCC ACCACACCTG ACCCATAGGT 6121 CTTCAATAAA TATTTAATGG AAGGTTCCAC AAGTCACCCT GTGATCAACA GTACCCGTAT 6181 GGGACAAAGC TGCAAGGTCA AGATGGTTCA TTATGGCTGT GTTCACCATA GCAAACTGGA 6241 AACAATCTAG ATATCCAACA GTGAGGGTTA AGCAACATGG TGCATCTGTG GATAGAACGC 6301 CACCCAGCCG CCCGGAGCAG GGACTGTCAT TCAGGGAGGC TAAGGAGAGA GGCTTGCTTG 6361 GGATATAGAA AGATATCCTG ACATTGGCCA GGCATGGTGG CTCACGCCTG TAATCCTGGC 6421 ACTTTGGGAG GACGAAGCGA GTGGATCACT GAAGTCCAAG AGTTTGAGAC CGGCCTGCGA 6481 GACATGGCAA AACCCTGTCT CAAAAAAGAA AGAATGATGT CCTGACATGA AACAGCAGGC EPI-109 691

6541 TACAAAACCA CTGCATGCTG TGATCCCAAT TTTGTGTTTT TCTTTCTATA TATGGATTAA 6601 AACAAAAATC CTAAAGGGAA ATACGCCAAA ATGTTGACAA TGACTGTCTC CAGGTCAAAG 6661 GAGAGAGGTG GGATTGTGGG TGACTTTTAA TGTGTATGAT TGTCTGTATT TTACAGAATT 6721 TCTGCCATGA CTGTGTATTT TGCATGACAC ATTTTAAAAA TAATAAACAC TATTTTTAGA 6781 ATAACAGAAT ATCAGCCTCC TCCTCTCCAA AAATAAGCCC TCAGGAGGGG ACAAAGTTGA 6841 CCGCTGATTG AGCCTGTCAG GGCTGTGCAC

(2) INFORMATION FOR SEQ ID NO: 2524: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1681 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2524:

1 gctgtagctg gtgagaggaa gtcctagagg ctatggacac tctgctgctg ggatcaccga

61 gatgagcagc agctgctcag ggctgagcag ggtcctggtg gccgtggcta cagccctggt

121 gtctgcctcc tccccctgcc cccaggcctg gggcccccca ggggtccagt atgggcagcc

181 agggaggtcc gtgaagctgt gttgtcctgg agtgactgcc ggggacccag tgtcctggtt

241 tcgggatggg gagccaaagc tgctccaggg acctgactct gggctagggc atgaactggt

301 cctggcccag gcagacagca ctgatgaggg cacctacatc tgccagaccc tggatggtgc

361 acttgggggc acagtgaccc tgcagctggg ctaccctcca gcccgccctg ttgtctcctg

421 ccaagcagcc gactatgaga acttctcttg cacttggagt cccagccaga tcagcggttt

481 acccacccgc tacctcacct cctacaggaa gaagacagtc ctaggagctg atagccagag

541 gaggagtcca tccacagggc cctggccatg cccacaggat cccctagggg ctgcccgctg

601 tgttgtccac ggggctgagt tctggagcca gtaccggatt aatgtgactg aggtgaaccc

661 actgggtgcc agcacacgcc tgctggatgt gagcttgcag agcatcttgc gccctgaccc

721 accccagggc ctgcgggtag agtcagtacc aggttacccc cgacgcctgc gagccagctg

781 gacataccct gcctcctggc cgtgccagcc ccacttcctg ctcaagttcc gtttgcagta

841 ccgtccggcg cagcatccag cctggtccac ggtggagcca gctggactgg aggaggtgat

901 cacagatgct gtggctgggc tgccccatgc tgtacgagtc agtgcccggg actttctaga

961 tgctggcacc tggagcacct ggagcccgga ggcctgggga actccgagca ctgggaccat

1021 accaaaggag ataccagcat ggggccagct acacacgcag ccagaggtgg agcctcaggt

1081 ggacagccct gctcctccaa ggccctccct ccaaccacac cctcggctac ttgatcacag

1141 ggactctgtg gagcaggtag ctgtgctggc gtctttggga atcctttctt tcctgggact

1201 ggtggctggg gccctggcac tggggctctg gctgaggctg agacggggtg ggaaggatgg

1261 atccccaaag cctgggttct tggcctcagt gattccagtg gacaggcgtc caggagctcc

1321 aaacctgtag aggacccagg agggcttcgg cagattccac ctataattct gtcttgctgg

1381 tgtggataga aaccaggcag gacagtagat ccctatggtt ggatctcagc tggaagttct

1441 gtttggagcc catttctgtg agaccctgta tttcaaattt gcagctgaaa ggtgcttgta

1501 cctctgattt caccccagag ttggagttct gctcaaggaa cgtgtgtaat gtgtacatct

1561 gtgtccatgt gtgaccatgt gtctgtgaag gccagggaac atgtattcct ctgcatgcat

1621 gtatgtaggt gcctgggagt gtgtgtggtc cttgctctgg ccctttccct tgcagggttg

1681 tgcaggtgtg aataaa

(2) INFORMATION FOR SEQ ID NO: 2525: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1681 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2525:

1 ggaagatgag cagcagctgc tcagggctga gcagggtcct ggtggccgtg gctacagccc

61 tggtgtctgc ctcctccccc tgcccccagg cctggggccc cccaggggtc cagtatgggc

121 agccaggcag gtccgtgaag ctgtgttgtc ctggagtgac tgccggggac ccagtgtcct

181 ggtttcggga tggggagcca aagctgctcc agggacctga ctctgggcta gggcatgaac

241 tggtcctggc ccaggcagac agcactgatg agggcaccta catctgccag accctggatg

301 gtgcacttgg gggcacagtg accctgcagc tgggctaccc tccagcccgc cctgttgtct

361 cctgccaagc agccgactat gagaacttct cttgcacttg gagtcccagc cagatcagcg

421 gtttacccac ccgctacctc acctcctaca ggaagaagac agtcctagga gctgatagcc

481 agaggaggag tccatccaca gggccctggc catgcccaca ggatccccta ggggctgccc

541 gctgtgttgt ccacggggct gagttctgga gccagtaccg gattaatgtg actgaggtga

601 acccactggg tgccagcaca cgcctgctgg atgtgagctt gcagagcatc ttgcgccctg

661 acccacccca gggcctgcgg gtagagtcag taccaggtta cccccgacgc ctgcgagcca

721 gctggacata ccctgcctcc tggccgtgcc agccccactt cctgctcaag ttccgtttgc

781 agtaccgtcc ggcgcagcat ccagcctggt ccacggtgga gccagctgga ctggaggagg

841 tgatcacaga tgctgtggct gggctgcccc atgctgtacg agtcagtgcc cgggactttc

901 tagatgctgg cacctggagc acctggagcc cggaggcctg gggaactccg agcactggga

961 ccataccaaa ggagatacca gcatggggcc agctacacac gcagccagag gtggagcctc

1021 aggtggacag ccctgctcct ccaaggccct ccctccaacc acaccctcgg ctacttgatc EPI-109 692

1081 acagggactc tgtggagcag gtagctgtgc tggcgtcttt gggaatcctt tctttcctgg 1141 gactggtggc tggggccctg gcactggggc tctggctgag gctgagacgg ggtgggaagg 1201 atggatcccc aaagcctggg ttcttggcct cagtgattcc agtggacagg cgtccaggag 1261 ctccaaacct gtagaggacc caggagggct tcggcagatt ccacctataa ttctgtcttg 1321 ctggtgtgga tagaaaccag gcaggacagt agatccctat ggttggatct cagctggaag 1381 ttctgtttgg agcccatttc tgtgagaccc tgtatttcaa atttgcagct gaaaggtgct 1441 tctacctctg atttcacccc agagttggag ttctgctcaa ggaacgtgtg taatgtgtac 1501 atctgtgtcc atgtgtgacc atgtgtctgt gaggcaggga acatgtattc tctgcatgca 1561 tgtatgtagg tgcctgggga gtgtgtgtgg gtccttggct cttggccttt ccttgcaggg 1621 gttgtgcagg tgtgaataaa gagaataagg aagttcttgg agattatact cagaaaaaaa 1681 aa

(2) INFORMATION FOR SEQ ID NO: 2526: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 361 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2526: 1 tctgtggagc aggtagctgt gctggcgtct ttgggaatcc tttctrtcct gggactggtg 61 gctggggccc tggcactggg gctctggtaa gtgactgcca ttggtccctc agcctctgat 121 cctcacacat gctctgatgc ccatagacca cattcatctc cacccttcat gactgcctgc 181 tgaacctgtc tgattctgga actacctccc catacctcca tcccctatgc cccacttgat 241 tttaactgat tcctctcctg accctttact aataaaccct ttggcggaga ctgagataac 301 ccacattgtt ggagagacag ctgcctttct atgccccagg ctgaggctga gacggggtgg 361 gaaggatgga tccccaaagc ctgggttctt ggcctcagtg attccagtgg

(2) INFORMATION FOR SEQ ID NO: 2527: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: - base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2527: 1 gctgtagctg gtgagaggaa gtcctagagg ctatggacac tctgctgctg ggatcaccga

61 gatgagcagc agctgctcag ggctgagcag ggtcctggtg gccgtggcta cagccctggt

121 gtctgcctcc tccccctgcc cccaggcctg gggcccccca ggggtccagt atgggcagcc

181 agggaggtcc gtgaagctgt gttgtcctgg agtgactgcc ggggacccag tgtcctggtt

241 tcgggatggg gagccaaagc tgctccaggg acctgactct gggctagggc atgaactggt

301 cctggcccag gcagacagca ctgatgaggg cacctacatc tgccagaccc tggatggtgc

361 acttgggggc acagtgaccc tgcagctggg ctaccctcca gcccgccctg ttgtctcctg

421 ccaagcagcc gactatgaga acttctcttg cacttggagt cccagccaga tcagcggttt

481 acccacccgc tacctcacct cctacaggaa gaagacagtc ctaggagctg atagccagag

541 gaggagtcca tccacagggc cctggccatg cccacaggat cccctagggg ctgcccgctg

601 tgttgtccac ggggctgagt tctggagcca gtaccggatt aatgtgactg aggtgaaccc

661 actgggtgcc agcacacgcc tgctggatgt gagcttgcag agcatcrtgc gccctgaccc

721 accccagggc ctgcgggtag agtcagtacc aggttacccc cgacgcctgc gagccagctg

781 gacataccct gcctcctggc cgtgccagcc ccacttcctg ctcaagttcc gtttgcagta

841 ccgtccggcg cagcatccag cctggtccac ggtggagcca gctggactgg aggaggtgat

901 cacagatgct gtggctgggc tgccccatgc tgtacgagtc agtgcccggg actttctaga

961 tgctggcacc tggagcacct ggagcccgga ggcctgggga actccgagca ctgggaccat

1021 accaaaggag ataccagcat ggggccagct acacacgcag ccagaggtgg agcctcaggt

1081 ggacagccct gctcctccaa ggccctccct ccaaccacac cctcggctac ttgatcacag

1141 ggactctgtg gagcaggtag ctgtgctggc gtctttggga atcctttctt tcctgggact

1201 ggtggctggg gccctggcac tggggctctg gctgaggctg agacggggtg ggaaggatgg

1261 atccccaaag cctgggttct tggcctcagt gattccagtg gacaggcgtc caggagctcc

1321 aaacctgtag aggacccagg agggcttcgg cagattccac ctataattct gtcttgctgg

1381 tgtggataga aaccaggcag gacagtagat ccctatggtt ggatctcagc tggaagttct

1441 gtttggagcc catttctgtg agaccctgta tttcaaattt gcagcrgaaa ggtgcttgta

1501 cctctgattt caccccagag ttggagttct gctcaaggaa cgtgtgtaat gtgtacatct

1561 gtgtccatgt gtgaccatgt gtctgtgaag gccagggaac atgtattcct ctgcatgcat

1621 gtatgtaggt gcctgggagt gtgtgtggtc cttgctctgg ccctttccct tgcagggttg

1681 tgcaggtgtg aataaa

1 ggaagatgag cagcagctgc tcagggctga gcagggtcct ggtggccgtg gctacagccc

61 tggtgtctgc ctcctccccc tgcccccagg cctggggccc cccaggggtc cagtatgggc

121 agccaggcag gtccgtgaag ctgtgttgtc ctggagtgac tgccggggac ccagtgtcct

181 ggtttcggga tggggagcca aagctgctcc agggacctga ctctgggcta gggcatgaac

241 tggtcctggc ccaggcagac agcactgatg agggcaccta catctcccag accctggatg

301 gtgcacttgg gggcacagtg accctgcagc tgggctaccc tccagcccgc cctgttgtct EPI-109 693

361 cctgccaagc agccgactat gagaacttct cttgcacttg gagtcccagc cagatcagcg

421 gtttacccac ccgctacctc acctcctaca ggaagaagac agtcctagga gctgatagcc

481 agaggaggag tccatccaca gggccctggc catgcccaca ggatccccta ggggctgccc

541 gctgtgttgt ccacggggct gagttctgga gccagtaccg gattaatgtg actgaggtga

601 acccactggg tgccagcaca cgcctgctgg atgtgagctt gcagagcatc ttgcgccctg

661 acccacccca gggcctgcgg gtagagtcag taccaggtta cccccgacgc ctgcgagcca

721 gctggacata ccctgcctcc tggccgtgcc agccccactt cctgctcaag ttccgtttgc

781 agtaccgtcc ggcgcagcat ccagcctggt ccacggtgga gccagctgga ctggaggagg

841 tgatcacaga tgctgtggct gggctgcccc atgctgtacg agtcagtgcc cgggactttc

901 tagatgctgg cacctggagc acctggagcc cggaggcctg gggaactccg agcactggga

961 ccataccaaa ggagatacca gcatggggcc agctacacac gcagccagag gtggagcctc

1021 aggtggacag ccctgctcct ccaaggccct ccctccaacc acaccctcgg ctacttgatc

1081 acagggactc tgtggagcag gtagctgtgc tggcgtcttt gggaatcctt tctttcctgg

1141 gactggtggc tggggccctg gcactggggc tctggctgag gctgagacgg ggtgggaagg

1201 atggatcccc aaagcctggg ttcttggcct cagtgattcc agtggacagg cgtccaggag

1261 ctccaaacct gtagaggacc caggagggct tcggcagatt ccacctataa ttctgtcttg

1321 ctggtgtgga tagaaaccag gcaggacagt agatccctat ggttggatct cagctggaag

1381 ttctgtttgg agcccatttc tgtgagaccc tgtatttcaa atttgcagct gaaaggtgct

1441 tctacctctg atttcacccc agagttggag ttctgctcaa ggaacgtgtg taatgtgtac

1501 atctgtgtcc atgtgtgacc atgtgtctgt gaggcaggga acatgtattc tctgcatgca

1561 tgtatgtagg tgcctgggga gtgtgtgtgg gtccttggct cttggccttt ccttgcaggg

1621 gttgtgcagg tgtgaataaa gagaataagg aagttcttgg agattatact cagaaaaaaa

1681 aa

1 tctgtggagc aggtagctgt gctggcgtct ttgggaatcc tttctttcct gggactggtg 61 gctggggccc tggcactggg gctctggtaa gtgactgcca ttggtccctc agcctctgat 121 cctcacacat gctctgatgc ccatagacca cattcatctc cacccttcat gactgcctgc 181 tgaacctgtc tgattctgga actacctccc catacctcca tcccctatgc cccacttgat 241 tttaactgat tcctctcctg accctttact aataaaccct ttggcggaga ctgagataac 301 ccacattgtt ggagagacag ctgcctttct atgccccagg ctgaggctga gacggggtgg 361 gaaggatgga tccccaaagc ctgggttctt ggcctcagtg attccagtgg aca

(2) INFORMATION FOR SEQ ID NO: 2528 (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 901 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xι)SEQUENCE DESCRIPTION: SEQ ID NO:2528:

1 cttcaactca ataagcattt taagtattct aatcttagta tttctctagc tgacatgtaa 61 gaagcaatct atcttattgt atgcaattag ctcattgtgt ggataaaaag gtaaaaccat 121 tctgaaacag gaaaccaata cacttcctgt ttaatcaaca aatctaaaca tttattcttt 181 tcatctgttt actcttgctc ttgtccacca caatatgcta ttcacatgtt cagtgtagtt 241 ttatgacaaa gaaaattttc tgagttactt ttgtatcccc acccccttaa agaaaggagg 301 aaaaactgtt tcatacagaa ggcgttaatt gcatgaatta gagctatcac ctaagtgtgg 361 gctaatgtaa caaagaggga tttcacctac atccattcag tcagtctttg ggggtttaaa 421 gaaattccaa agagtcatca gaagaggaaa aatgaaggta atgttttttc agacaggtaa 481 agtctttgaa aatatgtgta atatgtaaaa cattttgaca cccccataat atttttccag 541 aattaacagt ataaattgca tctcttgttc aagagttccc tatcactctc tttaatcact 601 actcacagta acctcaactc ctgccacaat gtacaggatg caactcctgt cttgcattgc 661 actaagtctt gcacttgtca caaacagtgc acctacttca agttctacaa agaaaacaca 721 gctacaactg gagcatttac ttctggattt acagatgatt ttgaatggaa ttaatgtaag 781 tatatttcct ttcttactaa aattattaca tttagtaatc tagctggaga tcatttctta 841 taacaatgca ttatactttc ttagaattac aagaatccca aactcaccag gatgctcaca 901 tttaagtttt acatgcccaa gaaggtaagt acaatatttt

(2) INFORMATION FOR SEQ ID NO:2529: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 9301 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2529:

1 gaattccctt ttcctagtca aagaaagggg tgacagacag cacctggaaa atcgtgtcac 61 tcccacccta atactgcgct tttccaatgg tcttagcaaa cagcacacca agagattata 121 tccagcacct ggctcagagg gtcctatgcc cacggagcct cactcactgc tagcacagca 181 gtctgagatc aaactgcaag gtggcagtga ggctgggaga ggggtgtgca ccattgccga 241 ggcttgagta ggtaaacaaa gcagctggga agctcgaact gggtggagcc cactgcagct 301 caaggaggcc tgcctgcctc tgtagactcc acctccgggg gcagggcata gccaaacaaa 361 aggcagcaga aacctctgca gacttaaatg tccctgtctg acagcttgga agagagtagt EPI-109 694

421 ggttctccca gcatgcagct tgagatctga gaatggacag actgcctcct caagtgggtc 481 cctgaccccc gagtaaccta actgggaggc accccaagta ggggcagact gacacctcac 541 atggctgggt actcctctga gaaaaaactt ccagaggaac gatcaggcag caacatttgc 601 tgttcaccaa tatccactgt tctgcagcct cctgtgctaa tacccaggca aatgggtctg 661 gagaggacct ccagcaagct ccaacagacc tacagctgag ggtcctgact gttagaagga 721 aaactaacaa acagaaagga catccacacc aaaaccctat ctgtacggca ccatcatcaa 781 agaccaaagg tagataaaac cacaaagatg gggaaaaaaa cacagcagaa aaactggtaa 841 ctctaaaaat tagagcgctt ctcctcctcc aaaggaacgc agctcctcac cagcaatgga 901 accaagctgg acagagaatg actttgacga gttgagagaa gaaggcttca gatgatcaaa 961 ctactctgag ctaaaggagg aagttcgaac ccacggcaaa gaagttaaaa accttgaaaa 1021 aaattagatg aatggctaac tagaataacc aatgcagaga agtccttaaa ggacctgatg 1081 gagctgaaaa ccatggcaca agaactacat gacaaatgca caagcctcag tagctgattc 1141 gatcaactgg aagaaagggt atcagtgatg gaagatcaaa tgaatgaaat gaagcaagaa 1201 gagaagttta gagaaaaaag aaaaaaaaga aatgaacaaa gcctccaaga aatatgggac 1261 tatgtgaaaa gaccaaatct acgtctgatt ggtgtacctg aaagtgatgg ggagaatgga 1321 accaagctgg aaaacactct gcaggatatt atccaagaga acttccccaa tctagcaagg 1381 caggctgaca ttcaaattca ggaaatacag agaacgccac aaatataatc ctcgagaaga 1441 gcaactccaa gacacataat tgttagattc actaaagttg aaatgaagga aaaaatgtta 1501 agggcagcca gagagaaagg tcagcttacc cacaaaggaa agcccatcag attaacagct 1561 gatctctcgg cagaaactct acaagccaga agagagtggg ggccaatatt caacattctt 1621 aaagaaaaga attttcaacc cagaatttca tatccagcca aactatgctt cataagtgaa 1681 ggagaaataa aatatagaca agtgaacgat gaaagatttt gtcaccacca ggcctgccct 1741 acaagagctc ctgaaggaag cactaaacat ggaaaggaac aaccggtacc agccactgca 1801 aaaacatgcc aaattgtaaa caccattgag gccaggaaga aactgcatca actaacgagc 1861 aaaataacca gctaacatca tcatgacagg atcaaattca cacataacaa tattaacctt 1921 aaatgtaaat aggctaaatg ctccaattaa aagacacaga ctggcaaact ggataaagag 1981 tcaagaccca tcagtgtgct gtattcagga aacccatctc acgtgcagag acacacatag 2041 gctcaaaata aagggatgga ggaagatcta ccaaacaaac ggaaaacaaa aaaaggcagg 2101 ggttgcaatc ctagtctctg ataaaacaga ctttaaacca acaaagatca aaagagacac 2161 agaaggccat tacataatgg taaagggatc aattcaacaa gaagagttaa ctatcctaaa 2221 tatatatgca cccaatacag gagcacctag attcataaag caagtcctta gagacctaca 2281 aagagactta gactcccaca caataataat gggagacttt aacaccccac tgtcaacatt 2341 agacagatca atgagacaga aaattaacaa ggatatccag gaattgaact caactctgca 2401 ccaagcggac ctaatagaca tctacagaac tctccacccc aaatcaacag aatatacatt 2461 cttttcggca ccacaccaca ccgattccaa aattgaacac atagttggaa gtaaagcact 2521 cctcagcaaa tgtaaaagaa cagaaagtac aacaaactgt ctctcagacc acagtgcaat 2581 caaactaaaa ctcaggatta agaaactcac tcaaaaccgc tcaactacat ggaaactgaa 2641 caacctgctc ctgaatgact actgggtaca taacgaaatg aaggcagaag taaagatgtt 2701 ctttgaaacc aacgagaaca aagacacaac ataccagaat ctctgggaca cattcaaagc 2761 agtgtgtaga ggaaaattta tagcactaaa tgcccacaag agaaagcagg aaagatctaa 2821 aattgacagc ctaacatcac aattaaaaga actagagaaa caagagcaaa cacattcaaa 2881 agctagcaga aggcaagaaa taactacaat cagagcagaa ctgaaggaga tagagacata 2941 caaaaaaccc ttcaaaaaat caatgaatcc aggagctggt tttttgaaaa gatcaacaaa 3001 attgatagac cactagcaaa actaatacag aagagagaag aatcaaatag acacaataaa 3061 aaatgataaa cgggatatca ccactgatcc cacagaaata caaactacca tcaaagaata 3121 ctataaacac ctctatgcaa ataaactaga aaatctagaa gaaatggata aattcctcga 3181 cacatacacc ctcccaagac taaaccagga agaagctgaa tctctgaata gaccaataac 3241 aggctctgaa attgaggcaa caattaacac cttaccaacc aataaaagtc caggaccaga 3301 tggattcaca gccaaattct accagaggta caaggaggag ctggtacgat tccttctgaa 3361 actattccaa tcaatagaaa aagagggaat cctccctaac tcattttatg aggccagcat 3421 catcctgata ccaaagcctg gcagagacac aacaaaaaaa gagaatttca gaccaatatc 3481 cctgatgaac atcgatgcaa aaatttttaa taaaatactg gcaaactgaa tccagcagca 3541 catcacaaag cttatccacc atgatcaagc tggcttcatt cctgggatgc aaggctggtt 3601 caacatacgg aaaatcaata aatgtaatcc agcatataaa cagaaccaac aacacacaac 3661 acatgattat ctcaacagat gcagaaaagg cctttgacaa aattcaacag cccttcatgc 3721 taaaaactct caataaatta ggtactgatg ggacgtatct caaaataata agcgctatct 3781 atgaccaacc cacagccaat atcatactgg atgggcaaaa actggaagca ttccctttga 3841 aaactggcac aagacaggga tgccctctct caccactcct attcaacaca gtgttcgaag 3901 ttctggcagg gcaatcaggc aggagaaaga aataaagggt attcaattag gaaaagagga 3961' ggtcaaattg tccctgtttg cagatgacat gattgtatat atagaaaacc ccattgtctc 4021 agcccaaaat ctccttaagc tgataagcaa cttcagcaaa gtctcaggat caaaatcaat 4081 gtgcaaaaat cacaagcatt cttatacacc aataacagac aaacagagag ccaaatcatg 4141 agtgaactcc cattcacaat tgcttcaaag agaataaaat acctaggaat ccaactcaca 4201 agggatgtga gagacctctt caaggagaac tataaaccac tgctcaatga aatgagagga 4261 tacagataaa tggaagaaca ttccatgctc atgggtagga agaatcaata tcgtgaaaat 4321 ggccatactg cccaaggtaa ttttatagat tcaatgccat ccccatcaag ctaccaatga 4381 ctttcttcac agaattggaa aaaactactt taaagttcat atggaaccaa aaaagagccc 4441 gcattgccaa gtcaatccta agccaaaaga acaaagctag aggcatcaca ctacctgact EPI-109 695

4501 tcaaactata ctacaaggct acagtaacca aaacagcatg gtactggtac caaagcagag 4561 atatagacca atggaacaaa acagtgccct cagaaataat actgcatatc tacaaccatc 4621 tgatctttga caaacctgac aaaaacaagc aatggggaaa ggattcccta tttaataaat 4681 ggtgctggga aaactggcta gccatatgta gaaagctgaa attggatccc ttccttacac 4741 cttgtacaaa aattaattca agatggatta cagacttaaa tgttagacct aaaaccataa 4801 aaaccctaga agaaaaccta ggcaatacca ttcaggacat aggcatgggc aagaacttca 4861 tgtctagaac accaaaagta atggcaacaa aagccaaaat tgacaaatgg gtctaattaa 4921 actaaagagc ttctgcacag caaaagaaac taccatcaga gtgaagaggc aacctacaga 4981 atgggagaaa atttttgcaa tctgacaaaa gggctaattt ttgcatctga caaagggcta 5041 atatccagaa tctacaatga actcaaacaa atttacaaga aaaaaacaaa tttacaagaa 5101 aaaaacaaaa tttacaagaa aaaaacaaat ttacaagaaa aaaacaaaca accccatcaa 5161 aaagtgggca aaggataaga acagtcactt ctcaaaagaa gacatttatg cagccaaaag 5221 acacatgaaa aaattctcat catcactggc catcagagaa atgcaaatca aaaccacaat 5281 gagataccat ctcacaccag ttagaatggc gatcattaaa aagtcaagaa acaacaggtg 5341 ctggagagga tgtggagaaa taggaacact tttacactgt tagtgggact gtaaactagt 5401 tcaacattgt ggaaatcagt atggcgattc ctcagggatc tagaactaga aataccattt 5461 gacccagcca tcccattact gggtatatac ccaaaggatt ataaatcatg ctgctataaa 5521 gacacttgca cacatatgtt tattgtggta ctattcacaa tagcaaagac ttggaattaa 5581 cccaaatgtc caacaatgat agactagatt aagaaaatgt ggcacatata cactatggaa 5641 tactttgcag ccataaaaaa ggatgagttc atgtcctttg tagggacatg gatgaagctg 5701 gaaaccatca ttctcggcaa actatcgcaa ggtcaaaaaa ccaaacaccg catgttctca 5761 ctcataggtg gtaactgaac aatgagaaca catggtcaca ggaaggggaa catcacgcac 5821 tggggcctgt tgtggggtgg ggggagtggg cagggatagc attaggagac atacctaatg 5881 ttaaatgacg atttaatggg tgcagcacac caacatggca catgtataca tatgtaacaa 5941 acccacacgt tgtgcacatg tactctaaaa cttaaagtat aattaaaata aataaataaa 6001 gtaaaaaaga aatcctaagg atactcaaat tgttgtttag gtgaagatgg atgatgcctt 6061 ccttgaatca tcagctacca ccgacagagt gaagtgagat ggaatagtgg gcacaatctc 6121 attcatccta ctctatgtag cctaatgggt ccagaattta tcatcactat tttacactgg 6181 aaaaaagatg agattatgag gggtcaggga ggctttgagt ttttgctcta acttcaccac 6241 taattaagaa tgtgatcttg ggtaagccac tttaacctct gtaaatgtca aatttcttat 6301 cagtaaaatg tgactataca agacaataaa tttgaaaata ctttgcaaaa ttgaaagtac 6361 catggaaata attcttcaat cccaaaaggt tatgaacatt attaaaattt gccacatgga 6421 agagcacaca ccacagagac ataactgtga tcataaacag atttacaaaa gtggtgtttc 6481 attatggagg gccatagggc tgataaagac aaatgcatca ccaagctatg tccgagctca 6541 ttcagatttt tacaggaaac acagagcttc tagctgaatt atctctggat ggtgtggaaa 6601 ttgtccaaca cgttcctaat ttcaaagaaa cagaactgaa tcttgaaaac ccaagaggcc 6661 tttacagaaa ctgacaagag atgaattaat ataggtatca agctacagac caaattaaag 6721 ttttacaaaa ctttgaaaga gggtcagaaa gaagaaactt atgggaagca gagtcctgga 6781 aagtcagctt tgatggagtg acaatatgtg caacacagtg agcaatctct taggtaggca 6841 gcttcaggga tgggggttgc cctttgaaag gacttgggcc actcttgagt ctaagaggct 6901 aagtcacaaa caatgctaag caactaaaaa tagcttcttg tttaatagta aaattctgca 6961 tagtaaaagg agaagcaggg ggtatgacac acgtggtagt tagcagtcta ctagtgactt 7021 tactgccaca accagaaaag ccagctgatg tgtcagacgt gagaaagcga aagtatgtca 7081 cagcgaatgt agcttttcca cacgtatttc aagaaagaaa tgaaaaaggc caacttctat 7141 aatggtgcct actgtgcatt aacagagata aactaggggt ctaagaactc agttttctac 7201 agggtcccag aagtatagcc atatattgcc ccattctcta atggaaatag ccagagaaat 7261 agaaatatca agactggaga acatcaaata cctcattgga aaagccccca cataggaaaa 7321 tgtgtgggct tgaattcttc cattctggaa gggtaaaggc ctgagtgatg atgctgggat 7381 tagacactga aactctttag agaagcaaaa caagtataat aaagctgtac tttattatat 7441 taaataaata acacacagac taccaaatag cctgcccctt ataacagcgt taatgtgatt 7501 ttgatctgaa atgtatagag acattttgca ttttttcggt ataaaaagtt catgagattt 7561 ggccctaatc tggacctttt cttcattttt ttttctactt gagggactat aatctttatt 7621 tttaaatttg ttttatattc tccgaacatt acctaacgca tagaaaactc ttcttgaacc 7681 atttttctct gttctttgta aaatattaca tttgactgtt ccttagactg ctttaatcat 7741 tcctgcctat gcaccctcct caaaatccag tttaaattaa ttgttcctta ttcaagattc 7801 cttatatcca cctcccttgg ggcagcaatc acctatcacc caggactaca cttgtgtatg 7861 tacatatctt ccctattaca aatcaggttc tttgaaaaaa tacaaatggt aagagagtgg 7921 atttttggag tcagtacatt ctcttttcaa atccttcttc tgccccttac tggcaataag 7981 ggctgagtga cctagagcaa attacttaac ttctctgagc ctcagttttc taatctgcaa 8041 aataggagcc atcacttcac aagtctgtaa gacttatatt agactaagtg cctgcctgta 8101 cactgttctc ttttctctct ttctatatac ctgaaggcat tataggtgct agatgtctgt 8161 ttaaagacca gacaatattg tcttaaaaaa acaaacaaaa acacagacaa taccatcttt 8221 aaaaaaaaaa aaaagtccag gtaagaaata aataaggcca tagaatggaa gctttacaag 8281 gactctctgt gagacaggat ctcctcaagt gtccccaggt taaattagaa gtatatatcc 8341 gtacaattgt tcagccagtt tgtgcactgt actgaggatg aatgaacacc tatcctaaat 8401 atcctagtct tctgactaaa aacaagatca tatttcataa cgattattgt tacattcata 8461 gtgtcccagg tgatttagag gataaataaa aatccattaa agaggtaaag acataaaaac 8521 gagaaacatg gactggttta cacataacac atacaaagtc tattataaaa ctagcatcag EPI-109 696

8581 tatccttgaa tgcaaacctt tttctgagta tttaacaatc gcacccttta aaaaatgtac

8641 aatagacatt aagagactta aacagatata taatcatttt aaattaaaat agcgttaaac

8701 agtacctcaa gctcaataag cattttaagt attctaatct tagtatttct ctagctgaca

8761 tgtaagaagc aatctatctt attgtatgca attagctcat tgtgtggata aaaaggtaaa

8821 accattctga aacaggaaac caatacactt cctgtttaat caacaaatct aaacatttat

8881 tcttttcatc tgtttactct tgctgttgtc caccacaata tgctattcac atgttcagtg

8941 tagttttatg acaaagaaaa ttttctgagt tacttttgta tccccacccc cttaaagaaa

9001 ggaggaaaaa ctgtttcata cagaaggcgt taattgcatg aattagagct atcacctaag

9061 tgtgggctaa tgtaacaaag agggatttca cctacatcca ttcagtcagt ctttgggggt

9121 ttaaagaaat tccaaagagt catcagaaga ggaaaaatga aggtaatgtt ttttcagaca

9181 ggtaaagtct ttgaaaatat gtgtaatatg taaaacattt tgacaccccc ataatatttt

9241 tccagaatta acagtataaa ttgcatctct tgttcaagag ttccctatca ctctctttaa 9301 tcactactca cagtaacctc aactcctgcc acaatgtac

(2) INFORMATION FOR SEQ ID NO: 2530: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 5701 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2530:

1 ttaatcaaca aatctaaaca tttattcttt tcatctgttt actcttgctc ttgttcacca

61 caatatgcta ttcacatgtt cagtgtagtt ttatgacaaa gaaaattttc tgagttactt

121 ttgtatcccc acccccttaa agaaaggagg aaaaactgtt tcatacagaa ggcgttaatt

181 gcatgaatta gagctatcac ctaagtgtgg gctaatgtaa caaagaggga tttcacctac

241 atccattcag tcagtctttg ggggtttaaa gaattccaaa gagtcatcag aagaggaaaa

301 atgaaggtaa tgttttttca gacaggtaaa gtctttgaaa atatgtgtaa tatgtaaaac

361 attttgacac ccccataata tttttccaga attaacagta taaattgcat ctcttgttca

421 agagttccct atcactctct ttaatcacta ctcacagtaa cctcaactcc tgccacaatg

481 tacaggatgc aactcctgtc ttgcattgca ctaagtcttg cacttgtcac aaacagtgca

541 cctacttcaa gttctacaaa gaaaacacag ctacaactgg agcatttact gctggattta

601 cagatgattt tgaatggaat taatgtaagt atatttcctt tcttactaaa attattacat

661 ttagtaatct agctggagat catttcttaa taacaatgca ttatactttc ttagaattac

721 aagaatccca aactcaccag gatgctcaca tttaagtttt acatgcccaa gaaggtaagt

781 acaatatttt atgttcaatt tctgttttaa taaaattcaa agtaatatga aaatttgcac

841 agatgggact aatagcagct catctgaggt aaagagtaac tttaatttgt ttttttgaaa

901 acccaagttt gataatgaag cctctattaa aacagtttta cctatatttt taatatatat

961 ttgtgtgttg gtgggggtgg gaagaaaaca taaaaataat attctcacct ttatcgataa

1021 gacaattcta aacaaaaatg ttcatttatg gtttcattta aaaatgtaaa actctaaaat

1081 atttgattat gtcattttag tatgtaaaat accaaaatct atttccaagg agcccacttt

1141 taaaaatctt ttcttgtttt aggaaaggtt tctaagtgag aggcagcata acactaatag

1201 cacagagtct ggggccagat atctgaagtg aaatctcagc tctgccatgt cctagctttc

1261 atgatctttg gcaaattacc tactctgttt gtgattcagt ttcatgtcta cttaaatgaa

1321 taactgtata tacttaatat ggctttgtga gaattagtaa gttaaatgta aagcactcag

1381 aaccgtgtct ggcataaggt aaataccata caagcattag ctattattag tagtattaaa

1441 gataaaattt tcactgagaa atacaaagta aaattttgga ctttatcttt ttaccaatag

1501 aacttgagat ttataatgct atatgactta ttttccaaga ttaaaagctt cattaggttg

1561 tttttggatt cagatagagc ataagcataa tcatccaagc tcctaggcta cattaggtgt

1621 gtaaagctac ctagtagttg tgccagttaa gagagaatga acaaaatctg gtgccagaaa

1681 gagcttgtgc cagggtgaat ccaagcccag aaaataatag gatttaaggg gacacagatg

1741 caatcccatt gactcaaatt ctattaattc aagagaaatc tgcttctaac tacccttctg

1801 aaagatgtaa aggagacag^'c ttacagatgt tactctagtt taatcagagc cacataatgc

1861 aactccagca acataaagat actagatgct gttttctgaa gaaaatttct ccacattgtt

1921 catgccaaaa acttaaaccc gaatttgtag aatttgtagt ggtgaattga aagcgcaata

1981 gatggacata tcaggggatt ggtattgtct tgacctacct ttcccactaa agagtgttag

2041 aaagatgaga ttatgtgcat aatttagggg gtggtagaat tcatggaaat ctaagtttga

2101 aaccaaaagt aatgataaac tctattcatt tgttcattta accctcattg cacatttaca

2161 aaagatttta gaaactaata aaaatatttg attccaagga tgctatgtta atgctataat

2221 gagaaagaaa tgaaatctaa ttctggctct acctacttat gtggtcaaat tctgagattt

2281 agtgtgctta tttataaagt ggagatgata cttcactgcc tacttcaaaa gatgactgtg

2341 agaagtaaat gggcctattt tggagaaaat tcttttaaat tgtaatatac catagaaata

2401 tgaaatatta tatataatat agaatcaaga ggcctgtcca aaagtcctcc caaagtatta

2461 taatctttta tttcactggg acaaacattt ttaaaatgca tcttaatgta gtgattgtag

2521 aaaagtaaaa tttaagacat atttaaaaat gtgtcttgct caaggctata ttgagagcca

2581 ctactacatg attattgtta cctagtgtaa aatgttggga ttgtgataga tggcattcaa

2641 gagttccttc tctctcaaca ttctgtgatt cttaactctt agactatcaa atattataat

2701 catagaatgt gatttttatg cttccacatt ctaactcatc tggttctaat gattttctat

2761 gcagattgga aaagtaatca gcctgcatct gtgataggca cttacgatgc agaaagtcta

2821 acattttgca aagccaaatt aagctaaaac cagtgagtca actatcactt aacgctagtc EPI-109 697

2881 ataggtactt gagccctagt ttttccagtt ttataatgta aactctactg gtccattctt 2941 tacagtgaca ttgagaacag agagaatggt aaaaactaca tactgctact ccaaataaaa 3001 taaattggaa attaatttct gattctgacc tctatgtaaa ctgagctgat gataattatt 3061 attctaggcc acagaactga aacatcttca gtgtctagaa gaagaactca aacctctgga 3121 ggaagtgcta aatttagctc aaagcaaaaa ctttcactta agacccaggg acttaatcag 3181 caatatcaac gtaatagttc tggaactaaa ggtaaggcat tactttattt gctctcctgg 3241 aaataaaaaa aaaaaagtca gggggaaaag taccacattt taaagtgaca taacattttt 3301 ggtatttgta aagtacccat gcatgtaatt agcctacatt ttaagtacac tgtgaacatg 3361 aatcatttct aatgttaaat gattaactgg ggagtataag ctactgagtt tgcacctacc 3421 atctactaat ggacaagcct catcccaaac tccatcacct ttcatattaa cacaaaactg 3481 ggagtgagag aaggtactga gttgagtttc acagaaagca ggcagatttt attatatatt 3541 tttcgattct tcagatcatt tactgaaata gccaatactg attacctgaa aggcttttca 3601 aatggtgttt ccttatcatt tgatggaagg actacccata agagatttgt cttaaaaaaa 3661 aaaactggag ccattaaaat ggccagtgga ctaaacaaac aacaatcttt ttagaggcaa 3721 tccccacttt cagaatctta agtattttta aatgcacagg aagcataaaa tatgcaaggg 3781 actcaggtga tgtaaaagag attcactttt gtctttttat atcccgtctc ctaaggtata 3841 aaattcatga gttaataggt atcctaaata agcagcataa gtatagtagt aaaagacatt 3901 cctaaaagta actccagttg tgtccaaatg aatcacttat tagtggactg tttcagttga 3961 attaaaaaaa tacattgaga tcaatgtcat ctagacattg acagattcag ttccttatct 4021 atggcaagag ttttactcta aaataattaa catcagaaaa ctcattctta actcttgata 4081 caaatttaag acaaaaccat gcaaaaatct gaaaactgtg tttcaaaagc caaacacttt 4141 ttaaaataaa aaatcccaag atatgacaat atttaaacaa ttatgcttaa gaggatacag 4201 aacactgcaa cagtttttta aaagagaata cttatttaaa gggaacactc tatctcacct 4261 gcttttgttc ccagggtagg aatcacttca aatttgaaaa gctctctttt aaatctcact 4321 atatatcaaa atatttcctc cttagcttat caactagagg aagcgtttaa atagctcctt 4381 tcagcagaga agcctaattt ctaaaaagcc agtccacaga acaaaatttc taatgtttaa 4441 acttttaaaa gttggcaaat tcacctgcat tgatactatg atggggtagg gataggtgta 4501 agtatttaga agatgttctt cacacaaatt tatcccaaac ggaagcatgt cctagcttac 4561 tctagtgtag ttctgttctg ctttggggaa aatataagga gattcactta agtagaaaaa 4621 taggagactc taatcaagat ttagaaaaga agaaagtata atgtgcatat caattcatac 4681 atttaactta cacaaatata ggtgtacatt cagaggaaaa gcgatcaagt ttatttcaca 4741 tccagcattt aatatttgtc tagatctatt tttatttaaa tctttatttg cacccaattt 4801 agggaaaaaa tttttgtgtt cattgactga attaacaaat gaggaaaatc tcagcttctg 4861 tgttactatc atttggtatc ataacaaaat atgtaatttt ggcattcatt ttgatcattt 4921 caagaaaatg cgaataatta atatgtttgg taagcttgaa aataaaggca acaggcctat 4981 aagacttcaa ttgggaataa ctgtatataa ggtaaactac tctgtacttt aaaaaattaa 5041 catttttctt ttatagggat ctgaaacaac attcatgtgt gaatatgctg atgagacagc 5101 aaccattgta gaatttctga acagatggat taccttttgt caaagcatca tctcaacact 5161 gacttgataa ttaagtgctt cccacttaaa acatatcagg ccttctattt atttaaatat 5221 ttaaatttta tatttattgt tgaatgtatg gtttgctacc tattgtaact attattctta 5281 atcttaaaac tataaatatg gatcttttat gattcttttt gtgccctagg ggctctaaaa 5341 tggtttcact tatttatccc aaaatattta ttattatgtt gaatgttaaa tatagtgcta 5401 tgtagattgg ttagtaaaac tatttaataa atttgataaa tataaacaag cctggatatt 5461 tgttattttg gaaacagcac agagtaagca tttaaatatt tcttagttac ttgtgtgaac 5521 tgtaggatgg ttaaaatgct tacaaaagtc actctttctc tgaagaaata tgtagaacag 5581 agatgtagac ttctcaaaag cccttgcttt gtcctttcaa gggctgatca gacccttagt 5641 tctggcatct cttagcagat tatattttcc ttcttcttaa aatgccaaac acaaacactc 5701 ttgaaactct tcatagattt ggtgtggcta tgaattc

(2) INFORMATION FOR SEQ ID NO: 2531: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 5521 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2531:

1 cgaattcccc tatcacctaa gtgtgggcta atgtaacaaa gagggatttc acctacatcc 61 attcagtcag tctttggggg tttaaagaaa ttccaaagag tcatcagaag aggaaaaatg 121 aaggtaatgt tttttcagac tggtaaagtc tttgaaaata tgtgtaatat gtaaaacatt 181 ttgacacccc cataatattt ttccagaatt aacagtataa attgcatctc ttgttcaaga 241 gttccctatc actctttaat cactactcac agtaacctca actcctgcca caatgtacag 301 gatgcaactc ctgtcttgca ttgcactaag tcttgcactt gtcacaaaca gtgcacctac 361 ttcaagttct acaaagaaaa cacagctaca actggagcat ttactgctgg atttacagat 421 gattttgaat ggaattaatg taagtatatt tcctttctta ctaaaattat tacatttagt 481 aatctagctg gagatcattt cttaataaca atgcattata ctttcttaga attacaagaa 541 tcccaaactc accaggatgc tcacatttaa gttttacatg cccaagaagg taagtacaat 601 attttatgtt caatttctgt tttaataaaa ttcaaagtaa tatgaaaatt tgcacagatg 661 ggactaatag cagctcatct gaggtaaaga gtaactttaa tttgtttttt tgaaaaccca 721 agtttgataa tgaagcctct attaaaacag ttttacctat atttttaata tatatttgtg EPI-109 698

781 tgttggtggg ggtgggagaa aacataaaaa taatattctc tcactttatc gataagacaa 841 ttctaaacaa aaatgttcat ttatggtttc atttaaaaat gtaaaactct aaaatatttg 901 attatgtcat tttagtatgt aaaataccaa aatctatttc caaggagccc acttttaaaa 961 atcttttctt gttttaggaa aggtttctaa gtgagaggca gcataacact aatagcacag 1021 agtctggggc cagatatctg aagtgaaatc tcagctctgc catgtcctag ctttcatgat 1081 ctttggcaaa ttacctactc tgtttgtgat tcagtttcat gtctacttaa atgaataact 1141 gtatatactt aatatggctt tgtgagaatt agtaagtaaa tgtaaagcac tcagaaccgt 1201 gtctggcata aggtaaatac catacaagca ttagctatta ttagtagtat taaagataaa 1261 attttcactg agaaatacaa agtaaaattt tggactttat ctttttacca atagaacttg 1321 agatttataa tgctatatga cttattttcc aagattaaaa gcttcattag gttgtttttg 1381 gattcagata gagcataagc ataatcatcc aagctcctag gctacattag gtgtgtaaag 1441 ctacctagta gctgtgccag ttaagagaga atgaacaaaa tctggtgcca gaaagagctt 1501 gtgccagggt gaatccaagc ccagaaaata ataggattta aggggacaca gatgcaatcc 1561 cattgactca aattctatta attcaagaga aatctgcttc taactaccct tctgaaagat 1621 gtaaaggaga cagcttacag atgttactct agtttaatca gagccacata atgcaactcc 1681 agcaacataa agatactaga tgctgttttc tgaagaaaat ttctccacat tgttcatgcc 1741 aaaaacttaa acccgaattt gtagaatttg tagtggtgaa ttgaaagcgc aatagatgga 1801 catatcaggg gattggtatt gtcttgacct acctttccca ctaaagagtg ttagaaagat 1861 gagattatgt gcataattta ggggtggtag aattcatgga aatctaagtt tgaaaccaaa 1921 agtaatgata aactctattc atttgttcat ttaaccctca ttgcacattt acaaaagatt 1981 ttagaaacta ataaaaatat ttgattccaa ggatgctatg ttaatgctat aatgagaaag 2041 aaatgaaatc taattctggc tctacctact tatgtggtca aattctgaga tttagtgtgc 2101 ttatttataa agtggagatg atacttcact gcctacttca aaagatgact gtgagaagta 2161 aatgggccta ttttggagaa aattctttta aattgtaata taccatagaa atatgaaata 2221 ttatatataa tatagaatca agaggcctgt ccaaaagtcc tcccaaagta ttataatctt 2281 ttatttcact gggacaaaca tttttaaaat gcatcttaat gtagtgattg tagaaaagta 2341 aaaatttaag acatatttaa aaatgtgtct tgctcaaggc tatattgaga gccactacta 2401 catgattatt gttacctagt gtaaaatgtt gggattgtga tagatggcat ccaagagttc 2461 cttctctctc aacattctgt gattcttaac tcttagacta tcaaatatta taatcataga 2521 atgtgatttt tatgccttcc acattctaat ctcatctggt tctaatgatt ttctatgcag 2581 attggaaaag taatcagcct acatctgtaa taggcattta gatgcagaaa gtctaacatt 2641 ttgcaaagcc aaattaagct aaaaccagtg agtcaactat cacttaacgc tagtcatagg 2701 tacttgagcc ctagtttttc cagttttata atgtaaactc tactggtcca tctttacagt 2761 gacattgaga acagagagaa tggtaaaaac tacatactgc tactccaaat aaaataaatt 2821 ggaaattaat ttctgattct gacctctatg taaactgagc tgatgataat tattattcta 2881 ggccacagaa ctgaaacatc ttcagtgtct agaagaagaa ctcaaacctc tggaggaagt 2941 gctaaattta gctcaaagca aaaactttca cttaagaccc agggacttaa tcagcaatat 3001 caacgtaata gttctggaac taaaggtaag gcattacttt atttgctctc ctggaaataa 3061 aaaaaaaaaa gtagggggaa aagtaccaca ttttaaagtg acataacatt tttggtattt 3121 gtaaagtacc catgcatgta attagcctac attttaagta cactgtgaac atgaatcatt 3181 tctaatgtta aatgattaac tggggagtat aagctactga gtttgcacct accatctact 3241 aatggacaag cctcatccca aactccatca cctttcatat taacacaaaa ctgggagtga 3301 gagagaagtg actgagttga gtttcacaga aacgcaggca agattttatt atatattttt 3361 caagttcctt cacagatcat ttactggaat agccaatact gagttacctg aaaggctttt 3421 caaatggtgt ttccttatca tttgatggaa ggactaccca taagagattt gtcttaaaaa 3481 aaaaaactgg agccattaaa atggccagtg gactaaacaa acaacaatct ttttagaggc 3541 aatcccactt tcagaatctt aagtattttt aaatgcacag gaagcataaa atatgcaagg 3601 gactcaggtg atgtaaaaga gattcacttt tgtcttttta tatcccgtct cctaaggtat 3661 aaaattcatg agttaatagg tatcctaaat aagcagcata agtatagtag taaaagacat 3721 tcctaaaagt aactccagtt gtgtccaaat gaatcactta ttagtggact gtttcagttg 3781 aattaaaaaa atacattgag atcaatgtca tctagacatt gacagattca gttccttatc 3841 tatggcaaga gttttactct aaaataatta acatcagaaa actcattctt aactcttgat 3901 acaaatttaa gacaaaacca tgcaaaaatc tgaaaactgt gtttcaaaag ccaaacactt 3961 tttaaaataa aaaaatccca agatatgaca atatttaaac aattatgctt aagaggatac 4021 agaacactgc aacagttttt taaaagagaa tacttattta aagggaacac tctatctcac 4081 ctgcttttgt tcccagggta ggaatcactt caaatttgaa aagctctctt ttaaatctca 4141 ctatatatca aaatagttgc ctccttagct tatcaactag aggaagcgtt taaatagctc 4201 ctttcagcag agaagcctaa tttctaaaaa gccagtccac agaacaaaat ttctaatgtt 4261 taaagctttt aaaagttggc aaattcacct gcattgatac tatgatgggg tagggatagg 4321 tgtaagtatt tatgaagatg ttcattcaca caaatttacc caaacaggaa gcatgtccta 4381 cctagcttac tctagtgtag ctcgtttcgt ctttggggaa aatataagga gattcactta 4441 agtagaaaaa taggagactc taatcaagat ttagaaaaga agaaagtata atgtgcatat 4501 caattcatac atttaactta cacaaatata ggtgtacatt cagaggaaaa gcgatcaagt 4561 ttatttcaca tccagcattt aatatttgtc tagatctatt tttatttaaa tctttatttg 4621 cacccaattt agggaaaaaa tttttgtgtt cattgactga attaacaaat gaggaaaatc 4681 tcagcttctg tgttactatc atttggtatc ataacaaaat acgcaatttt ggcattcatt 4741 ttgatcattt caagaaaatg tgaataatta atatgtttgg taagcttgaa aataaaggca 4801 acaggcctat aagacttcaa ttgggaataa ctgtatataa ggtaaactac tctgtacttt EPI-109 699

4861 aaaaaattaa cattttt tt ttatagggat ctgaaacaac attcatgtgt gaatatgctg

4921 atgagacagc aaccattgta gaatttctga acagatggat taccttttgt caaagcatca

4981 tctcaacact gacttgataa ttaagtgctt cccacttaaa acatatcagg ccttctattt

5041 atttaaatat ttaaatttta tatttattgt tgaatgtatg gtttgctacc tattgtaact

5101 attattctta atcttaaaac tataaatatg gatcttttat gattcttttt gtaagcccta

5161 ggggctctaa aatggtttca cttatttatc ccaaaatatt tattattatg ttgaatgtta

5221 aatatagtat ctatgtagat tggttagtaa aactatttaa taaatttgat aaatataaac

5281 aagcctggat atttgttatt ttggaaacag cacagagtaa gcatttaaat atttcttagt

5341 tacttgtgtg aactgtagga tggttaaaat gcttacaaaa gtcactcttt ctctgaagaa

5401 atatgtagaa cagagatgta gacttctcaa aagcccttgc tttgtccttt caagggctga

5461 tcagaccctt agttctggca tctcttagca gattatattt tccttcttct taaaatgcca

5521 aacacaaaca ctcttgaaac tcttcataga tttggtgtgg c

(2) INFORMATION FOR SEQ ID NO: 2532: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 841 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2532:

1 ccccataata tttttccaga attaacagta taaattgcat ctcttgttca agagttccct 61 atcactctct ttaatcacta ctcacagtaa cctcaactcc tgccacaatg tacaggatgc 121 aactcctgtc ttgcattgca ctaagtcttg cacttgtcac aaacagtgca cctacttcaa 181 gttctacaaa gaaaacacag ctacaactgg agcatttact gctggattta cagatgattt 241 tgaatggaat taataattac aagaatccca aactcaccag gatgctcaca tttaagtttt 301 acatgcccaa gaaggccaca gaactgaaac atcttcagtg tctagaagaa gaactcaaac 361 ctctggagga agtgctaaat ttagctcaaa gcaaaaactt tcacttaaga cccagggact 421 taatcagcaa tatcaacgta atagttctgg aactaaaggg atctgaaaca acattcatgt 481 gtgaatatgc tgatgagaca gcaaccattg tagaatttct gaacagatgg attacctttt 541 gtcaaagcat catctcaaca ctgacttgat aattaagtgc ttcccactta aaacatatca 601 ggccttctat ttatttaaat atttaaattt tatatttatt gttgaatgta tggtttgcta 661 cctattgtaa ctattattct taatcttaaa actataaata tggatctttt atgattcttt 721 ttgtaagccc taggggctct aaaatggttt cacttattta tcccaaaata tttattatta 781 tgttgaatgt taaatatagt atctatgtag attggttagt aaaactattt aataaatttg 841 ataa

(2) INFORMATION FOR SEQ ID NO: 2533: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22265 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2533:

1 cttcaactca ataagcattt taagtattct aatcttagta tttctctagc tgacatgtaa

61 gaagcaatct atcttattgt atgcaattag ctcattgtgt ggataaaaag gtaaaaccat 121 tctgaaacag gaaaccaata cacttcctgt ttaatcaaca aatctaaaca tttattcttt 181 tcatctgttt actcttgctc ttgtccacca caatatgcta ttcacatgtt cagtgtagtt 241 ttatgacaaa gaaaattttc tgagttactt ttgtatcccc acccccttaa agaaaggagg 301 aaaaactgtt tcatacagaa ggcgttaatt gcatgaatta gagctatcac ctaagtgtgg 361 gctaatgtaa caaagaggga tttcacctac atccattcag tcagtctttg ggggtttaaa 421 gaaattccaa agagtcatca gaagaggaaa aatgaaggta atgttttttc agacaggtaa 481 agtctttgaa aatatgtgta atatgtaaaa cattttgaca cccccataat atttttccag 541 aattaacagt ataaattgca tctcttgttc aagagttccc tatcactctc tttaatcact 601 actcacagta acctcaactc ctgccacaat gtacaggatg caactcctgt cttgcattgc 661 actaagtctt gcacttgtca caaacagtgc acctacttca agttctacaa agaaaacaca 721 gctacaactg gagcatttac ttctggattt acagatgatt ttgaatggaa ttaatgtaag 781 tatatttcct ttcttactaa aattattaca tttagtaatc tagctggaga tcatttctta 841 taacaatgca ttatactttc ttagaattac aagaatccca aactcaccag gatgctcaca 901 tttaagtttt acatgcccaa gaaggtaagt acaatatttt

1 gaattccctt ttcctagtca aagaaagggg tgacagacag cacctggaaa atcgtgtcac

61 tcccacccta atactgcgct tttccaatgg tcttagcaaa cagcacacca agagattata 121 tccagcacct ggctcagagg gtcctatgcc cacggagcct cactcactgc tagcacagca 181 gtctgagatc aaactgcaag gtggcagtga ggctgggaga ggggtgtgca ccattgccga 241 ggcttgagta ggtaaacaaa gcagctggga agctcgaact gggtggagcc cactgcagct 301 caaggaggcc tgcctgcctc tgtagactcc acctccgggg gcagggcata gccaaacaaa 361 aggcagcaga aacctctgca gacttaaatg tccctgtctg acagcttgga agagagtagt 421 ggttctccca gcatgcagct tgagatctga gaatggacag actgcctcct caagtgggtc 481 cctgaccccc gagtaaccta actgggaggc accccaagta ggggcagact gacacctcac 541 atggctgggt actcctctga gaaaaaactt ccagaggaac gatcaggcag caacatttgc EPI-109 700

601 tgttcaccaa tatccactgt tctgcagcct cctgtgctaa tacccaggca aatgggtctg 661 gagaggacct ccagcaagct ccaacagacc tacagctgag ggtcctgact gttagaagga 721 aaactaacaa acagaaagga catccacacc aaaaccctat ctgtacggca ccatcatcaa 781 agaccaaagg tagataaaac cacaaagatg gggaaaaaaa cacagcagaa aaactggtaa 841 ctctaaaaat tagagcgctt ctcctcctcc aaaggaacgc agctcctcac cagcaatgga 901 accaagctgg acagagaatg actttgacga gttgagagaa gaaggcttca gatgatcaaa 961 ctactctgag ctaaaggagg aagttcgaac ccacggcaaa gaagttaaaa accttgaaaa 1021 aaattagatg aatggctaac tagaataacc aatgcagaga agtccttaaa ggacctgatg 1081 gagctgaaaa ccatggcaca agaactacat gacaaatgca caagcctcag tagctgattc 1141 gatcaactgg aagaaagggt atcagtgatg gaagatcaaa tgaatgaaat gaagcaagaa 1201 gagaagttta gagaaaaaag aaaaaaaaga aatgaacaaa gcctccaaga aatatgggac 1261 tatgtgaaaa gaccaaatct acgtctgatt ggtgtacctg aaagtgatgg ggagaatgga 1321 accaagctgg aaaacactct gcaggatatt atccaagaga acttccccaa tctagcaagg 1381 caggctgaca ttcaaattca ggaaatacag agaacgccac aaatataatc ctcgagaaga 1441 gcaactccaa gacacataat tgttagattc actaaagttg aaatgaagga aaaaatgtta 1501 agggcagcca gagagaaagg tcagcttacc cacaaaggaa agcccatcag attaacagct 1561 gatctctcgg cagaaactct acaagccaga agagagtggg ggccaatatt caacattctt 1621 aaagaaaaga attttcaacc cagaatttca tatccagcca aactatgctt cataagtgaa 1681 ggagaaataa aatatagaca agtgaacgat gaaagatttt gtcaccacca ggcctgccct 1741 acaagagctc ctgaaggaag cactaaacat ggaaaggaac aaccggtacc agccactgca 1801 aaaacatgcc aaattgtaaa caccattgag gccaggaaga aactgcatca actaacgagc 1861 aaaataacca gctaacatca tcatgacagg atcaaattca cacataacaa tattaacctt 1921 aaatgtaaat aggctaaatg ctccaattaa aagacacaga ctggcaaact ggataaagag 1981 tcaagaccca tcagtgtgct gtattcagga aacccatctc acgtgcagag acacacatag 2041 gctcaaaata aagggatgga ggaagatcta ccaaacaaac ggaaaacaaa aaaaggcagg 2101 ggttgcaatc ctagtctctg ataaaacaga ctttaaacca acaaagatca aaagagacac 2161 agaaggccat tacataatgg taaagggatc aattcaacaa gaagagrtaa ctatcctaaa 2221 tatatatgca cccaatacag gagcacctag attcataaag caagtcctta gagacctaca 2281 aagagactta gactcccaca caataataat gggagacttt aacaccccac tgtcaacatt 2341 agacagatca atgagacaga aaattaacaa ggatatccag gaattgaact caactctgca 2401 ccaagcggac ctaatagaca tctacagaac tctccacccc aaatcaacag aatatacatt 2461 cttttcggca ccacaccaca ccgattccaa aattgaacac atagttggaa gtaaagcact 2521 cctcagcaaa tgtaaaagaa cagaaagtac aacaaactgt ctctcagacc acagtgcaat 2581 caaactaaaa ctcaggatta agaaactcac tcaaaaccgc tcaactacat ggaaactgaa 2641 caacctgctc ctgaatgact actgggtaca taacgaaatg aaggcagaag taaagatgtt 2701 ctttgaaacc aacgagaaca aagacacaac ataccagaat ctctgggaca cattcaaagc 2761 agtgtgtaga ggaaaattta tagcactaaa tgcccacaag agaaagcagg aaagatctaa 2821 aattgacagc ctaacatcac aattaaaaga actagagaaa caagagcaaa cacattcaaa 2881 agctagcaga aggcaagaaa taactacaat cagagcagaa ctgaaggaga tagagacata 2941 caaaaaaccc ttcaaaaaat caatgaatcc aggagctggt tttttgaaaa gatcaacaaa 3001 attgatagac cactagcaaa actaatacag aagagagaag aatcaaatag acacaataaa 3061 aaatgataaa cgggatatca ccactgatcc cacagaaata caaactacca tcaaagaata 3121 ctataaacac ctctatgcaa ataaactaga aaatctagaa gaaatggata aattcctcga 3181 cacatacacc ctcccaagac taaaccagga agaagctgaa tctctgaata gaccaataac 3241 aggctctgaa attgaggcaa caattaacac cttaccaacc aataaaagtc caggaccaga 3301 tggattcaca gccaaattct accagaggta caaggaggag ctggtacgat tccttctgaa 3361 actattccaa tcaatagaaa aagagggaat cctccctaac tcattttatg aggccagcat 3421 catcctgata ccaaagcctg gcagagacac aacaaaaaaa gagaatttca gaccaatatc 3481 cctgatgaac atcgatgcaa aaatttttaa taaaatactg gcaaactgaa tccagcagca 3541 catcacaaag cttatccacc atgatcaagc tggcttcatt cctgggatgc aaggctggtt 3601 caacatacgg aaaatcaata aatgtaatcc agcatataaa cagaaccaac aacacacaac 3661 acatgattat ctcaacagat gcagaaaagg cctttgacaa aattcaacag cccttcatgc 3721 taaaaactct caataaatta ggtactgatg ggacgtatct caaaataata agcgctatct 3781 atgaccaacc cacagccaat atcatactgg atgggcaaaa actggaagca ttccctttga 3841 aaactggcac aagacaggga tgccctctct caccactcct attcaacaca gtgttcgaag 3901 ttctggcagg gcaatcaggc aggagaaaga aataaagggt attcaattag gaaaagagga 3961 ggtcaaattg tccctgtttg cagatgacat gattgtatat atagaaaacc ccattgtctc 4021 agcccaaaat ctccttaagc tgataagcaa cttcagcaaa gtctcaggat caaaatcaat 4081 gtgcaaaaat cacaagcatt cttatacacc aataacagac aaacagagag ccaaatcatg 4141 agtgaactcc cattcacaat tgcttcaaag agaataaaat acctaggaat ccaactcaca 4201 agggatgtga gagacctctt caaggagaac tataaaccac tgctcaatga aatgagagga 4261 tacagataaa tggaagaaca ttccatgctc atgggtagga agaatcaata tcgtgaaaat 4321 ggccatactg cccaaggtaa ttttatagat tcaatgccat ccccatcaag ctaccaatga 4381 ctttcttcac agaattggaa aaaactactt taaagttcat atggaaccaa aaaagagccc 4441 gcattgccaa gtcaatccta agccaaaaga acaaagctag aggcatcaca ctacctgact 4501 tcaaactata ctacaaggct acagtaacca aaacagcatg gtactggtac caaagcagag 4561 atatagacca atggaacaaa acagtgccct cagaaataat actgcatatc tacaaccatc 4621 tgatctttga caaacctgac aaaaacaagc aatggggaaa ggattcccta tttaataaat EPI-109 701

4681 ggtgctggga aaactggcta gccatatgta gaaagctgaa attggatccc ttccttacac 4741 cttgtacaaa aattaattca agatggatta cagacttaaa tgttagacct aaaaccataa 4801 aaaccctaga agaaaaccta ggcaatacca ttcaggacat aggcatgggc aagaacttca 4861 tgtctagaac accaaaagta atggcaacaa aagccaaaat tgacaaatgg gtctaattaa 4921 actaaagagc ttctgcacag caaaagaaac taccatcaga gtgaagaggc aacctacaga 4981 atgggagaaa atttttgcaa tctgacaaaa gggctaattt ttgcatctga caaagggcta 5041 atatccagaa tctacaatga actcaaacaa atttacaaga aaaaaacaaa tttacaagaa 5101 aaaaacaaaa tttacaagaa aaaaacaaat ttacaagaaa aaaacaaaca accccatcaa 5161 aaagtgggca aaggataaga acagtcactt ctcaaaagaa gacatttatg cagccaaaag 5221 acacatgaaa aaattctcat catcactggc catcagagaa atgcaaatca aaaccacaat 5281 gagataccat ctcacaccag ttagaatggc gatcattaaa aagtcaagaa acaacaggtg 5341 ctggagagga tgtggagaaa taggaacact tttacactgt tagtgggact gtaaactagt 5401 tcaacattgt ggaaatcagt atggcgattc ctcagggatc tagaactaga aataccattt 5461 gacccagcca tcccattact gggtatatac ccaaaggatt ataaatcatg ctgctataaa 5521 gacacttgca cacatatgtt tattgtggta ctattcacaa tagcaaagac ttggaattaa 5581 cccaaatgtc caacaatgat agactagatt aagaaaatgt ggcacatata cactatggaa 5641 tactttgcag ccataaaaaa ggatgagttc atgtcctttg tagggacatg gatgaagctg 5701 gaaaccatca ttctcggcaa actatcgcaa ggtcaaaaaa ccaaacaccg catgttctca 5761 ctcataggtg gtaactgaac aatgagaaca catggtcaca ggaaggggaa catcacgcac 5821 tggggcctgt tgtggggtgg ggggagtggg cagggatagc attaggagac atacctaatg 5881 ttaaatgacg atttaatggg tgcagcacac caacatggca catgtataca tatgtaacaa 5941 acccacacgt tgtgcacatg tactctaaaa cttaaagtat aattaaaata aataaataaa 6001 gtaaaaaaga aatcctaagg atactcaaat tgttgtttag gtgaagatgg atgatgcctt 6061 ccttgaatca tcagctacca ccgacagagt gaagtgagat ggaatagtgg gcacaatctc 6121 attcatccta ctctatgtag cctaatgggt ccagaattta tcatcactat tttacactgg 6181 aaaaaagatg agattatgag gggtcaggga ggctttgagt ttttgctcta acttcaccac 6241 taattaagaa tgtgatcttg ggtaagccac tttaacctct gtaaatgtca aatttcttat 6301 cagtaaaatg tgactataca agacaataaa tttgaaaata ctttgcaaaa ttgaaagtac 6361 catggaaata attcttcaat cccaaaaggt tatgaacatt attaaaattt gccacatgga 6421 agagcacaca ccacagagac ataactgtga tcataaacag atttacaaaa gtggtgtttc 6481 attatggagg gccatagggc tgataaagac aaatgcatca ccaagctatg tccgagctca 6541 ttcagatttt tacaggaaac acagagcttc tagctgaatt atctctggat ggtgtggaaa 6601 ttgtccaaca cgttcctaat ttcaaagaaa cagaactgaa tcttgaaaac ccaagaggcc 6661 tttacagaaa ctgacaagag atgaattaat ataggtatca agctacagac caaattaaag 6721 ttttacaaaa ctttgaaaga gggtcagaaa gaagaaactt atgggaagca gagtcctgga 6781 aagtcagctt tgatggagtg acaatatgtg caacacagtg agcaatctct taggtaggca 6841 gcttcaggga tgggggttgc cctttgaaag gacttgggcc actcttgagt ctaagaggct 6901 aagtcacaaa caatgctaag caactaaaaa tagcttcttg tttaatagta aaattctgca 6961 tagtaaaagg agaagcaggg ggtatgacac acgtggtagt tagcagtcta ctagtgactt 7021 tactgccaca accagaaaag ccagctgatg tgtcagacgt gagaaagcga aagtatgtca 7081 cagcgaatgt agcttttcca cacgtatttc aagaaagaaa tgaaaaaggc caacttctat 7141 aatggtgcct actgtgcatt aacagagata aactaggggt ctaagaactc agttttctac 7201 agggtcccag aagtatagcc atatattgcc ccattctcta atggaaatag ccagagaaat 7261 agaaatatca agactggaga acatcaaata cctcattgga aaagccccca cataggaaaa 7321 tgtgtgggct tgaattcttc cattctggaa gggtaaaggc ctgagtgatg atgctgggat 7381 tagacactga aactctttag agaagcaaaa caagtataat aaagctgtac tttattatat 7441 taaataaata acacacagac taccaaatag cctgcccctt ataacagcgt taatgtgatt 7501 ttgatctgaa atgtatagag acattttgca ttttttcggt ataaaaagtt catgagattt 7561 ggccctaatc tggacctttt cttcattttt ttttctactt gagggactat aatctttatt 7621 tttaaatttg ttttatattc tccgaacatt acctaacgca tagaaaactc ttcttgaacc 7681 atttttctct gttctttgta aaatattaca tttgactgtt ccttagactg ctttaatcat 7741 tcctgcctat gcaccctcct caaaatccag tttaaattaa ttgttcctta ttcaagattc 7801 cttatatcca cctcccttgg ggcagcaatc acctatcacc caggactaca cttgtgtatg 7861 tacatatctt ccctattaca aatcaggttc tttgaaaaaa tacaaatggt aagagagtgg 7921 atttttggag tcagtacatt ctcttttcaa atccttcttc tgccccttac tggcaataag 7981 ggctgagtga cctagagcaa attacttaac ttctctgagc ctcagttttc taatctgcaa 8041 aataggagcc atcacttcac aagtctgtaa gacttatatt agactaagtg cctgcctgta 8101 cactgttctc ttttctctct ttctatatac ctgaaggcat tataggtgct agatgtctgt 8161 ttaaagacca gacaatattg tcttaaaaaa acaaacaaaa acacagacaa taccatcttt 8221. aaaaaaaaaa aaaagtccag gtaagaaata aataaggcca tagaatggaa gctttacaag 8281 gactctctgt gagacaggat ctcctcaagt gtccccaggt taaattagaa gtatatatcc 8341 gtacaattgt tcagccagtt tgtgcactgt actgaggatg aatgaacacc tatcctaaat 8401 atcctagtct tctgactaaa aacaagatca tatttcataa cgattattgt tacattcata 8461 gtgtcccagg tgatttagag gataaataaa aatccattaa agaggtaaag acataaaaac 8521 gagaaacatg gactggttta cacataacac atacaaagtc tattataaaa ctagcatcag 8581 tatccttgaa tgcaaacctt tttctgagta tttaacaatc gcacccttta aaaaatgtac 8641 aatagacatt aagagactta aacagatata taatcatttt aaattaaaat agcgttaaac 8701 agtacctcaa gctcaataag cattttaagt attctaatct tagtatttct ctagctgaca EPI-109 702

8761 tgtaagaagc aatctatctt attgtatgca attagctcat tgtgtggata aaaaggtaaa

8821 accattctga aacaggaaac caatacactt cctgtttaat caacaaatct aaacatttat

8881 tcttttcatc tgtttactct tgctgttgtc caccacaata tgctattcac atgttcagtg

8941 tagttttatg acaaagaaaa ttttctgagt tacttttgta tccccacccc cttaaagaaa

9001 ggaggaaaaa ctgtttcata cagaaggcgt taattgcatg aattagagct atcacctaag

9061 tgtgggctaa tgtaacaaag agggatttca cctacatcca ttcagtcagt ctttgggggt

9121 ttaaagaaat tccaaagagt catcagaaga ggaaaaatga aggtaatgtt ttttcagaca

9181 ggtaaagtct ttgaaaatat gtgtaatatg taaaacattt tgacaccccc ataatatttt

9241 tccagaatta acagtataaa ttgcatctct tgttcaagag ttccctatca ctctctttaa

9301 tcactactca cagtaacctc aactcctgcc acaatgtac

1 ttaatcaaca aatctaaaca tttattcttt tcatctgttt actcttgctc ttgttcacca

61 caatatgcta ttcacatgtt cagtgtagtt ttatgacaaa gaaaattttc tgagttactt

121 ttgtatcccc acccccttaa agaaaggagg aaaaactgtt tcatacagaa ggcgttaatt

181 gcatgaatta gagctatcac ctaagtgtgg gctaatgtaa caaagaggga tttcacctac

241 atccattcag tcagtctttg ggggtttaaa gaattccaaa gagtcatcag aagaggaaaa

301 atgaaggtaa tgttttttca gacaggtaaa gtctttgaaa atatgtgtaa tatgtaaaac

361 attttgacac ccccataata tttttccaga attaacagta taaattgcat ctcttgttca

421 agagttccct atcactctct ttaatcacta ctcacagtaa cctcaactcc tgccacaatg

481 tacaggatgc aactcctgtc ttgcattgca ctaagtcttg cacttgtcac aaacagtgca

541 cctacttcaa gttctacaaa gaaaacacag ctacaactgg agcatttact gctggattta

601 cagatgattt tgaatggaat taatgtaagt atatttcctt tcttactaaa attattacat

661 ttagtaatct agctggagat catttcttaa taacaatgca ttatactttc ttagaattac

721 aagaatccca aactcaccag gatgctcaca tttaagtttt acatgcccaa gaaggtaagt

781 acaatatttt atgttcaatt tctgttttaa taaaattcaa agtaatatga aaatttgcac

841 agatgggact aatagcagct catctgaggt aaagagtaac tttaatttgt ttttttgaaa

901 acccaagttt gataatgaag cctctattaa aacagtttta cctatatttt taatatatat

961 ttgtgtgttg gtgggggtgg gaagaaaaca taaaaataat attctcacct ttatcgataa

1021 gacaattcta aacaaaaatg ttcatttatg gtttcattta aaaatgtaaa actctaaaat

1081 atttgattat gtcattttag tatgtaaaat accaaaatct atttccaagg agcccacttt

1141 taaaaatctt ttcttgtttt aggaaaggtt tctaagtgag aggcagcata acactaatag

1201 cacagagtct ggggccagat atctgaagtg aaatctcagc tctgccatgt cctagctttc

1261 atgatctttg gcaaattacc tactctgttt gtgattcagt ttcatgtcta cttaaatgaa

1321 taactgtata tacttaatat ggctttgtga gaattagtaa gttaaatgta aagcactcag

1381 aaccgtgtct ggcataaggt aaataccata caagcattag ctattattag tagtattaaa

1441 gataaaattt tcactgagaa atacaaagta aaattttgga ctttatcttt ttaccaatag

1501 aacttgagat ttataatgct atatgactta ttttccaaga ttaaaagctt cattaggttg

1561 tttttggatt cagatagagc ataagcataa tcatccaagc tcctaggcta cattaggtgt

1621 gtaaagctac ctagtagttg tgccagttaa gagagaatga acaaaatctg gtgccagaaa

1681 gagcttgtgc cagggtgaat ccaagcccag aaaataatag gatttaaggg gacacagatg

1741 caatcccatt gactcaaatt ctattaattc aagagaaatc tgcttctaac tacccttctg

1801 aaagatgtaa aggagacagc ttacagatgt tactctagtt taatcagagc cacataatgc

1861 aactccagca acataaagat actagatgct gttttctgaa gaaaatttct ccacattgtt

1921 catgccaaaa acttaaaccc gaatttgtag aatttgtagt ggtgaattga aagcgcaata

1981 gatggacata tcaggggatt ggtattgtct tgacctacct ttcccactaa agagtgttag

2041 aaagatgaga ttatgtgcat aatttagggg gtggtagaat tcatggaaat ctaagtttga

2101 aaccaaaagt aatgataaac tctattcatt tgttcattta accctcattg cacatttaca

2161 aaagatttta gaaactaata aaaatatttg attccaagga tgctatgtta atgctataat

2221 gagaaagaaa tgaaatctaa ttctggctct acctacttat gtggtcaaat tctgagattt

2281 agtgtgctta tttataaagt ggagatgata cttcactgcc tacttcaaaa gatgactgtg

2341 agaagtaaat gggcctattt tggagaaaat tcttttaaat tgtaatatac catagaaata

2401 tgaaatatta tatataatat agaatcaaga ggcctgtcca aaagtcctcc caaagtatta

2461 taatctttta tttcactggg acaaacattt ttaaaatgca tcttaatgta gtgattgtag

2521 aaaagtaaaa tttaagacat atttaaaaat gtgtcttgct caaggctata ttgagagcca

2581 ctactacatg attattgtta cctagtgtaa aatgttggga ttgtgataga tggcattcaa

2641 gagttccttc tctctcaaca ttctgtgatt cttaactctt agactatcaa atattataat

2701 catagaatgt gatttttatg cttccacatt ctaactcatc tggttctaat gattttctat

2761 gcagattgga aaagtaatca gcctgcatct gtgataggca cttacgatgc agaaagtcta

2821 acattttgca aagccaaatt aagctaaaac cagtgagtca actatcactt aacgctagtc

2881 ataggtactt gagccctagt ttttccagtt ttataatgta aactctactg gtccattctt

2941 tacagtgaca ttgagaacag agagaatggt aaaaactaca tactgctact ccaaataaaa

3001 taaattggaa attaatttct gattctgacc tctatgtaaa ctgagctgat gataattatt

3061 attctaggcc acagaactga aacatcttca gtgtctagaa gaagaactca aacctctgga

3121 ggaagtgcta aatttagctc aaagcaaaaa ctttcactta agacccaggg acttaatcag

3181 caatatcaac gtaatagttc tggaactaaa ggtaaggcat tactttattt gctctcctgg

3241 aaataaaaaa aaaaaagtca gggggaaaag taccacattt taaagtgaca taacattttt

3301 ggtatttgta aagtacccat gcatgtaatt agcctacatt ttaagtacac tgtgaacatg

3361 aatcatttct aatgttaaat gattaactgg ggagtataag ctactgagtt tgcacctacc

3421 atctactaat ggacaagcct catcccaaac tccatcacct ttcatattaa cacaaaactg EPI-109 703

3481 ggagtgagag aaggtactga gttgagtttc acagaaagca ggcagatttt attatatatt 3541 tttcgattct tcagatcatt tactgaaata gccaatactg attacctgaa aggcttttca 3601 aatggtgttt ccttatcatt tgatggaagg actacccata agagatrtgt cttaaaaaaa 3661 aaaactggag ccattaaaat ggccagtgga ctaaacaaac aacaatcttt ttagaggcaa 3721 tccccacttt cagaatctta agtattttta aatgcacagg aagcataaaa tatgcaaggg 3781 actcaggtga tgtaaaagag attcactttt gtctttttat atcccgtctc ctaaggtata 3841 aaattcatga gttaataggt atcctaaata agcagcataa gtatagtagt aaaagacatt 3901 cctaaaagta actccagttg tgtccaaatg aatcacttat tagtggactg tttcagttga 3961 attaaaaaaa tacattgaga tcaatgtcat ctagacattg acagattcag ttccttatct 4021 atggcaagag ttttactcta aaataattaa catcagaaaa ctcattctta actcttgata 4081 caaatttaag acaaaaccat gcaaaaatct gaaaactgtg tttcaaaagc caaacacttt 4141 ttaaaataaa aaatcccaag atatgacaat atttaaacaa ttatgcttaa gaggatacag 4201 aacactgcaa cagtttttta aaagagaata cttatttaaa gggaacactc tatctcacct 4261 gcttttgttc ccagggtagg aatcacttca aatttgaaaa gctctctttt aaatctcact 4321 atatatcaaa atatttcctc cttagcttat caactagagg aagcgtttaa atagctcctt 4381 tcagcagaga agcctaattt ctaaaaagcc agtccacaga acaaaatttc taatgtttaa 4441 acttttaaaa gttggcaaat tcacctgcat tgatactatg atggggtagg gataggtgta 4501 agtatttaga agatgttctt cacacaaatt tatcccaaac ggaagcatgt cctagcttac 4561 tctagtgtag ttctgttctg ctttggggaa aatataagga gattcactta agtagaaaaa 4621 taggagactc taatcaagat ttagaaaaga agaaagtata atgtgcatat caattcatac 4681 atttaactta cacaaatata ggtgtacatt cagaggaaaa gcgatcaagt ttatttcaca 4741 tccagcattt aatatttgtc tagatctatt tttatttaaa tctttatttg cacccaattt 4801 agggaaaaaa tttttgtgtt cattgactga attaacaaat gaggaaaatc tcagcttctg 4861 tgttactatc atttggtatc ataacaaaat atgtaatttt ggcattcatt ttgatcattt 4921 caagaaaatg cgaataatta atatgtttgg taagcttgaa aataaaggca acaggcctat 4981 aagacttcaa ttgggaataa ctgtatataa ggtaaactac tctgtacttt aaaaaattaa 5041 catttttctt ttatagggat ctgaaacaac attcatgtgt gaatatgctg atgagacagc 5101 aaccattgta gaatttctga acagatggat taccttttgt caaagcatca tctcaacact 5161 gacttgataa ttaagtgctt cccacttaaa acatatcagg ccttctattt atttaaatat 5221 ttaaatttta tatttattgt tgaatgtatg gtttgctacc tattgtaact attattctta 5281 atcttaaaac tataaatatg gatcttttat gattcttttt gtgccctagg ggctctaaaa 5341 tggtttcact tatttatccc aaaatattta ttattatgtt gaatgttaaa tatagtgcta 5401 tgtagattgg ttagtaaaac tatttaataa atttgataaa tataaacaag cctggatatt 5461 tgttattttg gaaacagcac agagtaagca tttaaatatt tcttagttac ttgtgtgaac 5521 tgtaggatgg ttaaaatgct tacaaaagtc actctttctc tgaagaaata tgtagaacag 5581 agatgtagac ttctcaaaag cccttgcttt gtcctttcaa gggctgatca gacccttagt 5641 tctggcatct cttagcagat tatattttcc ttcttcttaa aatgccaaac acaaacactc 5701 ttgaaactct tcatagattt ggtgtggcta tgaattc

1 cgaattcccc tatcacctaa gtgtgggcta atgtaacaaa gagggatttc acctacatcc

61 attcagtcag tctttggggg tttaaagaaa ttccaaagag tcatcagaag aggaaaaatg

121 aaggtaatgt tttttcagac tggtaaagtc tttgaaaata tgtgtaatat gtaaaacatt

181 ttgacacccc cataatattt ttccagaatt aacagtataa attgcatctc ttgttcaaga

241 gttccctatc actctttaat cactactcac agtaacctca actcctgcca caatgtacag

301 gatgcaactc ctgtcttgca ttgcactaag tcttgcactt gtcacaaaca gtgcacctac

361 ttcaagttct acaaagaaaa cacagctaca actggagcat ttactgctgg atttacagat

421 gattttgaat ggaattaatg taagtatatt tcctttctta ctaaaattat tacatttagt

481 aatctagctg gagatcattt cttaataaca atgcattata ctttcttaga attacaagaa

541 tcccaaactc accaggatgc tcacatttaa gttttacatg cccaagaagg taagtacaat

601 attttatgtt caatttctgt tttaataaaa ttcaaagtaa tatgaaaatt tgcacagatg

661 ggactaatag cagctcatct gaggtaaaga gtaactttaa tttgtttttt tgaaaaccca

721 agtttgataa tgaagcctct attaaaacag ttttacctat atttttaata tatatttgtg

781 tgttggtggg ggtgggagaa aacataaaaa taatattctc tcactttatc gataagacaa

841 ttctaaacaa aaatgttcat ttatggtttc atttaaaaat gtaaaactct aaaatatttg

901 attatgtcat tttagtatgt aaaataccaa aatctatttc caaggagccc acttttaaaa

961 atcttttctt gttttaggaa aggtttctaa gtgagaggca gcataacact aatagcacag

1021 agtctggggc cagatatctg aagtgaaatc tcagctctgc catgtcctag ctttcatgat

1081 ctttggcaaa ttacctactc tgtttgtgat tcagtttcat gtctacttaa atgaataact

1141 gtatatactt aatatggctt tgtgagaatt agtaagtaaa tgtaaagcac tcagaaccgt

1201 gtctggcata aggtaaatac catacaagca ttagctatta ttagtagtat taaagataaa

1261 attttcactg agaaatacaa agtaaaattt tggactttat ctttttacca atagaacttg

1321 agatttataa tgctatatga cttattttcc aagattaaaa gcttcattag gttgtttttg

1381 gattcagata gagcataagc ataatcatcc aagctcctag gctacattag gtgtgtaaag

1441 ctacctagta gctgtgccag ttaagagaga atgaacaaaa tctggtgcca gaaagagctt

1501 gtgccagggt gaatccaagc ccagaaaata ataggattta aggggacaca gatgcaatcc

1561 cattgactca aattctatta attcaagaga aatctgcttc taactaccct tctgaaagat

1621 gtaaaggaga cagcttacag atgttactct agtttaatca gagccacata atgcaactcc

1681 agcaacataa agatactaga tgctgttttc tgaagaaaat ttctccacat tgttcatgcc

1741 aaaaacttaa acccgaattt gtagaatttg tagtggtgaa ttgaaagcgc aatagatgga EPI-109 704

1801 catatcaggg gattggtatt gtcttgacct acctttccca ctaaagagtg ttagaaagat 1861 gagattatgt gcataattta ggggtggtag aattcatgga aatctaagtt tgaaaccaaa 1921 agtaatgata aactctattc atttgttcat ttaaccctca ttgcacattt acaaaagatt 1981 ttagaaacta ataaaaatat ttgattccaa ggatgctatg ttaatgctat aatgagaaag 2041 aaatgaaatc taattctggc tctacctact tatgtggtca aattctgaga tttagtgtgc 2101 ttatttataa agtggagatg atacttcact gcctacttca aaagatgact gtgagaagta 2161 aatgggccta ttttggagaa aattctttta aattgtaata taccatagaa atatgaaata 2221 ttatatataa tatagaatca agaggcctgt ccaaaagtcc tcccaaagta ttataatctt 2281 ttatttcact gggacaaaca tttttaaaat gcatcttaat gtagtgattg tagaaaagta 2341 aaaatttaag acatatttaa aaatgtgtct tgctcaaggc tatattgaga gccactacta 2401 catgattatt gttacctagt gtaaaatgtt gggattgtga tagatggcat ccaagagttc 2461 cttctctctc aacattctgt gattcttaac tcttagacta tcaaatatta taatcataga 2521 atgtgatttt tatgccttcc acattctaat ctcatctggt tctaatgatt ttctatgcag 2581 attggaaaag taatcagcct acatctgtaa taggcattta gatgcagaaa gtctaacatt 2641 ttgcaaagcc aaattaagct aaaaccagtg agtcaactat cacttaacgc tagtcatagg 2701 tacttgagcc ctagtttttc cagttttata atgtaaactc tactggtcca tctttacagt 2761 gacattgaga acagagagaa tggtaaaaac tacatactgc tactccaaat aaaataaatt 2821 ggaaattaat ttctgattct gacctctatg taaactgagc tgatgataat tattattcta 2881 ggccacagaa ctgaaacatc ttcagtgtct agaagaagaa ctcaaacctc tggaggaagt 2941 gctaaattta gctcaaagca aaaactttca cttaagaccc agggacttaa tcagcaatat 3001 caacgtaata gttctggaac taaaggtaag gcattacttt atttgctctc ctggaaataa 3061 aaaaaaaaaa gtagggggaa aagtaccaca ttttaaagtg acataacatt tttggtattt 3121 gtaaagtacc catgcatgta attagcctac attttaagta cactgtgaac atgaatcatt 3181 tctaatgtta aatgattaac tggggagtat aagctactga gtttgcacct accatctact 3241 aatggacaag cctcatccca aactccatca cctttcatat taacacaaaa ctgggagtga 3301 gagagaagtg actgagttga gtttcacaga aacgcaggca agattttatt atatattttt 3361 caagttcctt cacagatcat ttactggaat agccaatact gagttacctg aaaggctttt 3421 caaatggtgt ttccttatca tttgatggaa ggactaccca taagagattt gtcttaaaaa 3481 aaaaaactgg agccattaaa atggccagtg gactaaacaa acaacaatct ttttagaggc 3541 aatcccactt tcagaatct.t aagtattttt aaatgcacag gaagcataaa atatgcaagg 3601 gactcaggtg atgtaaaaga gattcacttt tgtcttttta tatcccgtct cctaaggtat 3661 aaaattcatg agttaatagg tatcctaaat aagcagcata agtatagtag taaaagacat 3721 tcctaaaagt aactccagtt gtgtccaaat gaatcactta ttagtggact gtttcagttg 3781 aattaaaaaa atacattgag atcaatgtca tctagacatt gacagattca gttccttatc 3841 tatggcaaga gttttactct aaaataatta acatcagaaa actcattctt aactcttgat 3901 acaaatttaa gacaaaacca tgcaaaaatc tgaaaactgt gtttcaaaag ccaaacactt 3961 tttaaaataa aaaaatccca agatatgaca atatttaaac aattatgctt aagaggatac 4021 agaacactgc aacagttttt taaaagagaa tacttattta aagggaacac tctatctcac 4081 ctgcttttgt tcccagggta ggaatcactt caaatttgaa aagctctctt ttaaatctca 4141 ctatatatca aaatagttgc ctccttagct tatcaactag aggaagcgtt taaatagctc 4201 ctttcagcag agaagcctaa tttctaaaaa gccagtccac agaacaaaat ttctaatgtt 4261 taaagctttt aaaagttggc aaattcacct gcattgatac tatgatgggg tagggatagg 4321 tgtaagtatt tatgaagatg ttcattcaca caaatttacc caaacaggaa gcatgtccta 4381 cctagcttac tctagtgtag ctcgtttcgt ctttggggaa aatataagga gattcactta 4441 agtagaaaaa taggagactc taatcaagat ttagaaaaga agaaagtata atgtgcatat 4501 caattcatac atttaactta cacaaatata ggtgtacatt cagaggaaaa gcgatcaagt 4561 ttatttcaca tccagcattt aatatttgtc tagatctatt tttatttaaa tctttatttg 4621 cacccaattt agggaaaaaa tttttgtgtt cattgactga attaacaaat gaggaaaatc 4681 tcagcttctg tgttactatc atttggtatc ataacaaaat acgcaatttt ggcattcatt 4741 ttgatcattt caagaaaatg tgaataatta atatgtttgg taagcttgaa aataaaggca 4801 acaggcctat aagacttcaa ttgggaataa ctgtatataa ggtaaactac tctgtacttt 4861 aaaaaattaa catttttctt ttatagggat ctgaaacaac attcatgtgt gaatatgctg 4921 atgagacagc aaccattgta gaatttctga acagatggat taccttttgt caaagcatca 4981 tctcaacact gacttgataa ttaagtgctt cccacttaaa acatatcagg ccttctattt 5041 atttaaatat ttaaatttta tatttattgt tgaatgtatg gtttgctacc tattgtaact 5101 attattctta atcttaaaac tataaatatg gatcttttat gattcttttt gtaagcccta 5161 ggggctctaa aatggtttca cttatttatc ccaaaatatt tattattatg ttgaatgtta 5221 aatatagtat ctatgtagat tggttagtaa aactatttaa taaatttgat aaatataaac 5281 aagcctggat atttgttatt ttggaaacag cacagagtaa gcatttaaat atttcttagt 5341 tacttgtgtg aactgtagga tggttaaaat gcttacaaaa gtcactcttt ctctgaagaa 5401 atatgtagaa cagagatgta gacttctcaa aagcccttgc tttgtccttt caagggctga 5461 tcagaccctt agttctggca tctcttagca gattatattt tccttcttct taaaatgcca 5521 aacacaaaca ctcttgaaac tcttcataga tttggtgtgg c 1 ccccataata tttttccaga attaacagta taaattgcat ctcttgttca agagttccct 61 atcactctct ttaatcacta ctcacagtaa cctcaactcc tgccacaatg tacaggatgc 121 aactcctgtc ttgcattgca ctaagtcttg cacttgtcac aaacagtgca cctacttcaa 181 gttctacaaa gaaaacacag ctacaactgg agcatttact gctggattta cagatgattt 241 tgaatggaat taataattac aagaatccca aactcaccag gatgctcaca tttaagtttt EPI-109 705

301 acatgcccaa gaaggccaca gaactgaaac atcttcagtg tctagaagaa gaactcaaac

361 ctctggagga agtgctaaat ttagctcaaa gcaaaaactt tcacttaaga cccagggact

421 taatcagcaa atcaacgta atagttctgg aactaaaggg atctgaaaca acattcatgt

481 gtgaatatgc tgatgagaca gcaaccattg tagaatttct gaacagatgg attacctttt

541 gtcaaagcat catctcaaca ctgacttgat aattaagtgc ttcccactta aaacatatca

601 ggccttctat ttatttaaat atttaaattt tatatttatt gttgaatgta tggtttgcta

661 cctattgtaa ctattattct taatcttaaa actataaata tggatctttt atgattcttt

721 ttgtaagccc taggggctct aaaatggttt cacttattta tcccaaaata tttattatta

781 tgttgaatgt taaatatagt atctatgtag attggttagt aaaactattt aataaatttg

841 ataa

(2) INFORMATION FOR SEQ ID NO:2534: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 901 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2534:

1 aggcccagtt gaaaccaggg agttgctctc ctttctcctc ccttgacctc acccctcaga

61 ccatgccaat tctgcctcct aaacctccca ggccagcccc tcccccagct cccagtgaca

121 gtgtcctcag gtacctgagc tcagctctcg gtgctaccag agggactgca gggctgcaga

181 ggctgagtcc cacacgcagg gaacagccat gccactgcta gcagaccagt aagagaatgg

241 ccacctgggg cctgagcgcc ctcggccatc caccagaaac aaagtgtcaa ggagaagctg

301 cccgaagccc atgggacaaa ccactgggga ctggaacacc agtaattctg tattgggaag

361 cggcaccaag agatgtgctt ctcagagcct gaggctgaac gtggatgttt agcagcgtga

421 ccggctacca gacaaactct catctgttcc agtggcctcc tggccaccca ccaggaccaa

481 gcagggcggg cagcagaggg ccagggtagt ccaggtgatg gcagatgaga tcccactggg

541 caggaggcct cagtgagctg agtcaggctt ccccttcctg ccacaggggt cctctcacct

601 gctgccatgc ttcccatctc tcatcctcct tgacaagatg aagtgatacc gtttaagtaa

661 tcttttttct tgtttcactg atcttgagta ctagaaagtc atggatgaat aattacgtct

721 gtggttttct atggaggttc catgtcagat aaagatcctt ccgacgcctg ccccacacca

781 ccacctcccc cgccttgccc ggggttgtgg gcaccttgct gctgcacata taaggcggga

841 gctgttgcca actcttcaga gccccacgaa ggaccagaac aagacagagt gcctcctgcc 901 gatccaaaca tgagccgcc

(2) INFORMATION FOR SEQ ID NO:2535: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 421 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2535: 1 gccacccacc aggaccaagc agggcgggca gcagagggcc agggtagtcc aggtgatggc 61 agatgagatc ccactgggca ggaggcctca gtgagctgag tcaggcttcc ccttcctgcc 121 acaggggtcc tctcacctgc tgccatgctt cccatctctc atcctccttg acaagatgaa 181 gtgataccgt ttaagtaatc ttttttcttg tttcactgat cttgagtact agaaagtcat 241 ggatgaataa ttacgtctgt ggttttctat ggaggttcca tgtcagataa agatccttcc 301 gacgcctgcc ccacaccacc acctcccccc gccttgcccg gggttgtggg caccttgctg 361 ctgcacatat aaggcgggag gttgttgcca actcttcaga gccccacgaa ggaccagaac 421 aagacagagt gcctcctgcc gatccaaaca tg

(2) INFORMATION FOR SEQ ID NO: 2536: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2701 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2536:

1 gatccaggag accagtctcc tagtaccagg tctgcttgcc taaacttgga gtataagagc

61 catagacact gtctcttcga tcagtccttg cccccacccc ctgctgttgc acccttatct

121 ttcaccctat tgctcctgca ttgaagacag aagcacccag tttcccctgc ctcagcataa

181 cttgctagcc ttcatttcct cgtgctggtc acatcacacc acaacccgac ccaaaccctg

241 gtttctctac catgcccctg cttccctgca ccccaggctt gtcacactca tcttctacca

301 aaactccagc tttgtgctgt ggcctgtcaa cctgtcccat ggaaaagggg gccaccccat

361 ccttcaggga ctgtcccctg gctctccaca ctcctggctt tgccactttc tctctagctg

421 tggtttctca ggtcctttga gaacttccca taactgtccc tgtttccttc ccacctctgt

481 aggcctgagc tgcaaaccag ctcccactcc acccaggctc cagggccgac tgggatttag

541 atccctcaat atggctttcc ttcagggagt agttctcttc tctcctcttg ccctcccggc

601 tcaaacttgt ccatgccacc tgctacaccg tcctgcagct cccagtaact aacactattc EPI-109 706

661 tcaaggccca cctttgtccc taggtcccta agcctaatta tctgagttat cagaaggatg

721 gcctagtgtt tgcagtcata tctccatcaa gggttctgtc ctctagatgt gggccttagc

781 gcattgcctt actgcactga gactagacca gtgaaggagt gagctgaact ccatatccac

841 ctgcaaggaa taagggtcaa tgggaaggct gcctagaggg agagggagct ctagctacca

901 gcggccagag gactagccca cccatggacg tttaaccatg tgccagaatg cctaccatgt

961 tcaagtttgc cccagtgacc ctggtggccc actaatagtg gtggcccaca gtcaggggca

1021 gatttgtaca agggatggta ggaagaggtt ccagtgcaca gaaaccccaa gctggctcgg

1081 agccaggcta cttcctccca ccacctgttt ccactcggtc catctctatg acaaaggaag

1141 aagatggcct ttgaataagc agtctttctt cccatgtcga taattttgag tactagaaaa

1201 cgatgaataa gtctgtggtt tgctatggag gttccatgtc agataaagct gcttctgatg

1261 cctgcccttc cccccatgcc ctgcctgggg cccgccccgc ccctctcgat gaatatatat

1321 aaggtgaagg ctcctgtggc ttcttcagaa ctctttggag gaccagaacg agacaatggt

1381 tcttgccagc tctaccacca gcatcctctg tatgctgctc ccgctcctga tgctcttcca

1441 ccagggactc cagatttcag acaggggctc agatgcccac catttactca ggacgttgga

1501 ttgcaggact attgccttgg agattttggt gaagctccca gtgagtagct ggctgaggtt

1561 agcctgggca ggctggcttc aacaggtgcc tcggaccaat aagcctcatg attctttctt

1621 ttagtatcct caggtatctg gactcaataa tagtgacgac aaagccaatc tgagggtaag

1681 agccctgctc ttgggcattc ttgggttcca tctgtctcct gcctgggtga ctttagccat

1741 gtcactgcac cctgctttgc ttccgttttc acatctatct cagtggggtt attaaggaaa

1801 tcatcagatg actctctgag cctcagtctg tgccacagcc agctgcaata atgaaagttg

1861 cattttagga gatacaatgg agagagaact gtgagtgaac cctgccacag gcctctggct

1921 ccactttcag tggggatgcc atggggatgc catggaccag tgaacgagtt gccttctgtg

1981 actgtgtctt ttgcttttct tcctcctcca aaactgagct tgtgttctcc acttccacca

2041 gcctaagaca ttaccatttg cagttatttt cccagctcta gttagataca atggttctgt

2101 ttcgttttta tttgtttgca agcgtgctga gtgtctacgt ttcccctccc tagggacatg

2161 atgaagtctg taggattttc ttctagatat ctagaagttc ttaattaaat taaagcattg

2221 gggttgggga tttagctcag tggtagagtg cttgcctagc aagcgcaagg ccctgagttc

2281 attccccagc tccgaaaaaa agaaaaaaga aaaagaaaaa aaattaaagc attaaccttg

2341 gtgtttggca tcttgggcat aagtatttcc cttggccaac cttctgcctt ttctagagct

2401 tgtctggaga gatatgtttc ccttaaaaac agacagatct gcttagagcc ttcacacagt

2461 ccacaggctg ccaggggtta agacctggtg ctcaggagaa acaggccctt gtctgggatg

2521 tgccctagct ttagccccag gataaggaaa ggaccaggag taaggctgtt caaagaaacc

2581 tctaacagca gtcacacctc cccagctctc acctccccag ctctcacctc cccagctctc

2641 acctctcccg ctctcacctc cccagctctc acctctccag ctctcacttc cccagttctc

2701 acctccccag ctctcacctc tccagctctc acctccccag ctctcacct

(2) INFORMATION FOR SEQ ID NO: 2537: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 901 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2537:

1 cagagcccca cgaaggacca gaacaagaca gagtgcctcc tgccgatcca aacatgagcc

61 gcctgcccgt cctgctcctg ctccaactcc tggtccgccc cggactccaa gctcccatga

121 cccagacaac gcccttgaag acaagctggg ttaactgctc taacatgatc gatgaaatta

181 taacacactt aaagcagcca cctttgcctt tgctggactt caacaacctc aatggggaag

241 accaagacat tctgatggaa aataaccttc gaaggccaaa cctggaggca ttcaacaggg

301 ctgtcaagag tttacagaac gcatcagcaa ttgagagcat tcttaaaaat ctcctgccat

361 gtctgcccct ggccacggcc gcacccacgc gacatccaat ccatatcaag gacggtgact

421 ggaatgaatt ccggaggaaa ctgacgttct atctgaaaac ccttgagaat gcgcaggctc

481 aacagacgac tttgagcctc gcgatctttt agtccaacgt ccagctcgtt ctctgggcct

541 tctcaccaca gagcctcggg acatcaaaaa cagcagaact tctgaaacct ctgggtcatc

601 tctcacacat tccaggacca gaagcatttc accttttcct gcggcatcag atgaattgtt

661 aattatctaa tttctgaaat gtgcagctcc catttggcct tgtgcggttg tgttctcatt

721 tttatcccat tgagactatt tatttatgta tgtatgtatt tatttattta ttgcctggag

781 tgtgaactgt atttatttta gcagaggagc catgtcctgc tgcttctgca aaaaactcag

841 agtggggtgg ggagcatgtt catttgtacc tcgagtttta aactggttcc tagggatgtg

901 tgagaataaa ctagactctg aac

(2) INFORMATION FOR SEQ ID NO: 2538: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 841 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi)SEQUENCE DESCRIPTION: SEQ ID NO:2538:

1 tgtgtaagta agtgcaagct acagagaaaa ccaaggaaga aaaaaattgc cagagatcca

61 ggttaaaaaa aaaaaaagaa aaagaaaaga aaaccaagga agcaatcatc ataaaagaca EPI-109 707

121 ggtgagtggg ttacctctaa gggcgagcag tcacgattag aggacaaata tggggagagt 181 tttggagcgt tggcgatttt tttttgactt aagcatggtt aaatgggtga ttgcttataa 241 ttacttgtta aattaggtta attaggtttt atttacatgt tttatgctct tttctgcatg 301 catttgtgct ctattttttt aattaaaaaa taaaataaag taaaactatg tttcttgcac 361 ttaaaatact ggaaaaccaa agagaatctg aaaaactttt agaatgaaga gagtttggca 421 agacggcaag aacccttgct ttttccactg ggcctttctt cctcccaccc tgagggtgct 481 ccatggaaaa tgcaaatcta cttaactgac tttcgcaaat gtcaaatgta gagtacgaat 541 ttcaagggga gcctggggct gtgccatatc ctgctgtgag ctacagtttt ccagcctcta 601 gagccatctt aacaaggtgc ctgcctggtg tctactaccc cagtatgtgc tccaacccct 661 gcccaggcct cctagtgcta gagaggatat agacatggcc tctccatgga aacctccagg 721 gctggtatga caccttaaca aacaaaaagg gaggattgcc ggtacagcgg agtcccgcag 781 gaggataggt gttgccttct aggtggtagg gaggctgaga gggccatcca gagtagggac 841 cacgaactgg ggtctcaaca tgaagagtcg ttcatcagat ct

(2) INFORMATION FOR SEQ ID NO: 2539: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2581 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2539:

1 aggcccagtt gaaaccaggg agttgctctc ctttctcctc ccttgacctc acccctcaga 61 ccatgccaat tctgcctcct aaacctccca ggccagcccc tcccccagct cccagtgaca 121 gtgtcctcag gtacctgagc tcagctctcg gtgctaccag agggactgca gggctgcaga 181 ggctgagtcc cacacgcagg gaacagccat gccactgcta gcagaccagt aagagaatgg 241 ccacctgggg cctgagcgcc ctcggccatc caccagaaac aaagtgtcaa ggagaagctg 301 cccgaagccc atgggacaaa ccactgggga ctggaacacc agtaattctg tattgggaag 361 cggcaccaag agatgtgctt ctcagagcct gaggctgaac gtggatgttt agcagcgtga 421 ccggctacca gacaaactct catctgttcc agtggcctcc tggccaccca ccaggaccaa 481 gcagggcggg cagcagaggg ccagggtagt ccaggtgatg gcagatgaga tcccactggg 541 caggaggcct cagtgagctg agtcaggctt ccccttcctg ccacaggggt cctctcacct 601 gctgccatgc ttcccatctc tcatcctcct tgacaagatg aagtgatacc gtttaagtaa 661 tcttttttct tgtttcactg atcttgagta ctagaaagtc atggatgaat aattacgtct 721 gtggttttct atggaggttc catgtcagat aaagatcctt ccgacgcctg ccccacacca 781 ccacctcccc cgccttgccc ggggttgtgg gcaccttgct gctgcacata taaggcggga 841 gctgttgcca actcttcaga gccccacgaa ggaccagaac aagacagagt gcctcctgcc 901 gatccaaaca tgagccgcc

1 gccacccacc aggaccaagc agggcgggca gcagagggcc agggtagtcc aggtgatggc 61 agatgagatc ccactgggca ggaggcctca gtgagctgag tcaggcttcc ccttcctgcc 121 acaggggtcc tctcacctgc tgccatgctt cccatctctc atcctccttg acaagatgaa 181 gtgataccgt ttaagtaatc ttttttcttg tttcactgat cttgagtact agaaagtcat 241 ggatgaataa ttacgtctgt ggttttctat ggaggttcca tgtcagataa agatccttcc 301 gacgcctgcc ccacaccacc acctcccccc gccttgcccg gggttgtggg caccttgctg 361 ctgcacatat aaggcgggag gttgttgcca actcttcaga gccccacgaa ggaccagaac 421 aagacagagt gcctcctgcc gatccaaaca tg

1 gatccaggag accagtctcc tagtaccagg tctgcttgcc taaacttgga gtataagagc

61 catagacact gtctcttcga tcagtccttg cccccacccc ctgctgttgc acccttatct

121 ttcaccctat tgctcctgca ttgaagacag aagcacccag tttcccctgc ctcagcataa

181 cttgctagcc ttcatttcct cgtgctggtc acatcacacc acaacccgac ccaaaccctg

241 gtttctctac catgcccctg cttccctgca ccccaggctt gtcacactca tcttctacca

301 aaactccagc tttgtgctgt ggcctgtcaa cctgtcccat ggaaaagggg gccaccccat

361 ccttcaggga ctgtcccctg gctctccaca ctcctggctt tgccactttc tctctagctg

421 tggtttctca ggtcctttga gaacttccca taactgtccc tgtttccttc ccacctctgt

481 aggcctgagc tgcaaaccag ctcccactcc acccaggctc cagggccgac tgggatttag

541 atccctcaat atggctttcc ttcagggagt agttctcttc tctcctcttg ccctcccggc

601 tcaaacttgt ccatgccacc tgctacaccg tcctgcagct cccagtaact aacactattc

661 tcaaggccca cctttgtccc taggtcccta agcctaatta tctgagttat cagaaggatg

721 gcctagtgtt tgcagtcata tctccatcaa gggttctgtc ctctagatgt gggccttagc

781 gcattgcctt actgcactga gactagacca gtgaaggagt gagctgaact ccatatccac

841 ctgcaaggaa taagggtcaa tgggaaggct gcctagaggg agagggagct ctagctacca

901 gcggccagag gactagccca cccatggacg tttaaccatg tgccagaatg cctaccatgt

961 tcaagtttgc cccagtgacc ctggtggccc actaatagtg gtggcccaca gtcaggggca

1021 gatttgtaca agggatggta ggaagaggtt ccagtgcaca gaaaccccaa gctggctcgg

1081 agccaggcta cttcctccca ccacctgttt ccactcggtc catctctatg acaaaggaag

1141 aagatggcct ttgaataagc agtctttctt cccatgtcga taattttgag tactagaaaa

1201 cgatgaataa gtctgtggtt tgctatggag gttccatgtc agataaagct gcttctgatg

1261 cctgcccttc cccccatgcc ctgcctgggg cccgccccgc ccctctcgat gaatatatat

1321 aaggtgaagg ctcctgtggc ttcttcagaa ctctttggag gaccagaacg agacaatggt

1381 tcttgccagc tctaccacca gcatcctctg tatgctgctc ccgctcctga tgctcttcca EPI-109 708

1441 ccagggactc cagatttcag acaggggctc agatgcccac catttactca ggacgttgga

1501 ttgcaggact attgccttgg agattttggt gaagctccca gtgagtagct ggctgaggtt

1561 agcctgggca ggctggcttc aacaggtgcc tcggaccaat aagcctcatg attctttctt

1621 ttagtatcct caggtatctg gactcaataa tagtgacgac aaagccaatc tgagggtaag

1681 agccctgctc ttgggcattc ttgggttcca tctgtctcct gcctgggtga ctttagccat

1741 gtcactgcac cctgctttgc ttccgttttc acatctatct cagtggggtt attaaggaaa

1801 tcatcagatg actctctgag cctcagtctg tgccacagcc agctgcaata atgaaagttg

1861 cattttagga gatacaatgg agagagaact gtgagtgaac cctgccacag gcctctggct

1921 ccactttcag tggggatgcc atggggatgc catggaccag tgaacgagtt gccttctgtg

1981 actgtgtctt ttgcttttct tcctcctcca aaactgagct tgtgttctcc acttccacca

2041 gcctaagaca ttaccatttg cagttatttt cccagctcta gttagataca atggttctgt

2101 ttcgttttta tttgtttgca agcgtgctga gtgtctacgt ttcccctccc tagggacatg

2161 atgaagtctg taggattttc ttctagatat ctagaagttc ttaattaaat taaagcattg

2221 gggttgggga tttagctcag tggtagagtg cttgcctagc aagcgcaagg ccctgagttc

2281 attccccagc tccgaaaaaa agaaaaaaga aaaagaaaaa aaattaaagc attaaccttg

2341 gtgtttggca tcttgggcat aagtatttcc cttggccaac cttctgcctt ttctagagct

2401 tgtctggaga gatatgtttc ccttaaaaac agacagatct gcttagagcc ttcacacagt

2461 ccacaggctg ccaggggtta agacctggtg ctcaggagaa acaggccctt gtctgggatg

2521 tgccctagct ttagccccag gataaggaaa ggaccaggag taaggctgtt caaagaaacc

2581 tctaacagca gtcacacctc cccagctctc acctccccag ctctcacctc cccagctctc

2641 acctctcccg ctctcacctc cccagctctc acctctccag ctctcacttc cccagttctc

2701 acctccccag ctctcacctc tccagctctc acctccccag ctctcacct

1 cagagcccca cgaaggacca gaacaagaca gagtgcctcc tgccgatcca aacatgagcc

61 gcctgcccgt cctgctcctg ctccaactcc tggtccgccc cggactccaa gctcccatga

121 cccagacaac gcccttgaag acaagctggg ttaactgctc taacatgatc gatgaaatta

181 taacacactt aaagcagcca cctttgcctt tgctggactt caacaacctc aatggggaag

241 accaagacat tctgatggaa aataaccttc gaaggccaaa cctggaggca ttcaacaggg

301 ctgtcaagag tttacagaac gcatcagcaa ttgagagcat tcttaaaaat ctcctgccat

361 gtctgcccct ggccacggcc gcacccacgc gacatccaat ccatatcaag gacggtgact

421 ggaatgaatt ccggaggaaa ctgacgttct atctgaaaac ccttgagaat gcgcaggctc

481 aacagacgac tttgagcctc gcgatctttt agtccaacgt ccagctcgtt ctctgggcct

541 tctcaccaca gagcctcggg acatcaaaaa cagcagaact tctgaaacct ctgggtcatc

601 tctcacacat tccaggacca gaagcatttc accttttcct gcggcatcag atgaattgtt

661 aattatctaa tttctgaaat gtgcagctcc catttggcct tgtgcggttg tgttctcatt

721 tttatcccat tgagactatt tatttatgta tgtatgtatt tatttattta ttgcctggag

781 tgtgaactgt atttatttta gcagaggagc catgtcctgc tgcttctgca aaaaactcag

841 agtggggtgg ggagcatgtt catttgtacc tcgagtttta aactggttcc tagggatgtg 901 tgagaataaa ctagactctg aac

1 tgtgtaagta agtgcaagct acagagaaaa ccaaggaaga aaaaaattgc cagagatcca

61 ggttaaaaaa aaaaaaagaa aaagaaaaga aaaccaagga agcaatcatc ataaaagaca

121 ggtgagtggg ttacctctaa gggcgagcag tcacgattag aggacaaata tggggagagt

181 tttggagcgt tggcgatttt tttttgactt aagcatggtt aaatgggtga ttgcttataa

241 ttacttgtta aattaggtta attaggtttt atttacatgt tttatgctct tttctgcatg

301 catttgtgct ctattttttt aattaaaaaa taaaataaag taaaactatg tttcttgcac

361 ttaaaatact ggaaaaccaa agagaatctg aaaaactttt agaatgaaga gagtttggca

421 agacggcaag aacccttgct ttttccactg ggcctttctt cctcccaccc tgagggtgct

481 ccatggaaaa tgcaaatcta cttaactgac tttcgcaaat gtcaaatgta gagtacgaat

541 ttcaagggga gcctggggct gtgccatatc ctgctgtgag ctacagtttt ccagcctcta

601 gagccatctt aacaaggtgc ctgcctggtg tctactaccc cagtatgtgc tccaacccct

661 gcccaggcct cctagtgcta gagaggatat agacatggcc tctccatgga aacctccagg

721 gctggtatga caccttaaca aacaaaaagg gaggattgcc ggtacagcgg agtcccgcag

781 gaggataggt gttgccttct aggtggtagg gaggctgaga gggccatcca gagtagggac

841 cacgaactgg ggtctcaaca tgaagagtcg ttcatcagat ct

(2) INFORMATION FOR SEQ ID NO: 2540: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1441 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2540:

1 gcacacggga agatatcaga aacatcctag gatcaggaca ccccagatct tctcaactgg

61 aaccacgaag gctgtttctt ccacacagca ctttgatctc catttaagca ggcacctctg

121 tcctgcgttc cggagctgcg ttcccgatgg tcctcctttg gctcacgctg ctcctgatcg

181 ccctgccctg tctcctgcaa acgaaggaag atccaaaccc accaatcacg aacctaagga

241 tgaaagcaaa ggctcagcag ttgacctggg accttaacag aaatgtgacc gatatcgagt

301 gtgttaaaga tgccgactat tctatgccgg cagtgaacaa tagctattgc cagtttggag

361 caatttcctt atgtgaagtg accaactaca ccgtccgagt ggccaaccca ccattctcca

421 cgtggatcct cttccctgag aacagtggga agccttgggc aggtgcggag aatctgacct EPI-109 709

481 gctggattca tgacgtggat ttcttgagct gcagctgggc ggtaggcccg ggggcccccg

541 cggacgtcca gtacgacctg tacttgaacg ttgccaacag gcgtcaacag tacgagtgtc

601 ttcactacaa aacggatgct cagggaacac gtatcgggtg tcgtttcgat gacatctctc

661 gactctccag cggttctcaa agttcccaca tcctggtgcg gggcaggagc gcagccttcg

721 gtatcccctg cacagataag tttgtcgtct tttcacagat tgagatatta actccaccca

781 acatgactgc aaagtgtaat aagacacatt cctttatgca ctggaaaatg agaagtcatt

841 tcaatcgcaa atttcgctat gagcttcaga tacaaaagag aatgcagcct gtaatcacag

901 aacaggtcag agacagaacc tccttccagc tactcaatcc tggaacgtac acagtacaaa

961 taagagcccg ggaaagagtg tatgaattct tgagcgcctg gagcaccccc cagcgcttcg

1021 agtgcgacca ggaggagggc gcaaacacac gtgcctggcg gacgtcgctg ctgatcgcgc

1081 tggggacgct gctggccctg gtctgtgtct tcgtgatctg cagaaggtat ctggtgatgc

1141 agagactctt tccccgcatc cctcacatga aagaccccat cggtgacagc ttccaaaacg

1201 acaagctggt ggtctgggag gcgggcaaag ccggcctgga ggagtgtctg gtgactgaag

1261 tacaggtcgt gcagaaaact tgagactggg gttcagggct tgtgggggtc tgcctcaatc

1321 tccctggccg ggccaggcgc ctgcacagac tggctgctgg acctgcgcac gcagcccagg

1381 aatggacatt cctaacgggt ggtgggcatg ggagatgcct gtgtaatttc gtccgaagct

1441 gccaggaaga agaacagaac

(2) INFORMATION FOR SEQ ID NO: 2541: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 601 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2541:

1 gatcgttagc ttctcctgat aaactaattg cctcacattg tcactgcaaa tcgacaccta

61 ttaatgggtc tcacctccca actgcttccc cctctgttct tcctgctagc atgtgccggc

121 aactttgtcc acggacacaa gtgcgatatc accttacagg agatcatcaa aactttgaac

181 agcctcacag agcagaagac tctgtgcacc gagttgaccg taacagacat ctttgctgcc

241 tccaagaaca caactgagaa ggaaaccttc tgcagggctg cgactgtgct ccggcagttc

301 tacagccacc atgagaagga cactcgctgc ctgggtgcga ctgcacagca gttccacagg

361 cacaagcagc tgatccgatt cctgaaacgg ctcgacagga acctctgggg cctggcgggc

421 ttgaattcct gtcctgtgaa ggaagccaac cagagtacgt tggaaaactt cttggaaagg

481 ctaaagacga tcatgagaga gaaatattca aagtgttcga gctgaatatt ttaatttatg

541 agtttttgat agctttattt tttaagtatt tatatattta taactcatca taaaataaag 601 tatatataga atct

(2) INFORMATION FOR SEQ ID NO: 2542: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 9841 base- pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2542:

1 gaattcaata aaaaacaagc agggcgcgtg gtggggcact gactaggagg gctgatttgt

61 aagttggtaa gactgtagct ctttttccta attagctgag gatgtgttta ggttccattc

121 aaaaagtggg cattcctggc caggcatggt ggctcacacc tgtaatctca gagctttggg

181 agactgaggt aggaggatca cttgagccca ggaatttgag atgagcctag gcaacatagt

241 gagactctta tctctatcaa aaaataaaaa taaaaatgag ccaggcatgg tgcggtggac

301 cacgcaccta ctgctagggg ggctgaggtg ggaggatcat tgagcctggg aggttgaggc

361 tgcagtgatc cctgatcaaa cattgcattt cagcctgggt gacagagtga gaccctgtct

421 cagaaaaaaa aaaaaaaagt cattcctgaa acctcagaat agacctacct tgccaagggc

481 ttccttatgg gtaaggacct tatggacctg ctgggaccca aactaggcct cacctgatac

541 gacctgtcct tctcaaaaca ctaaacttgg gagaacattg tcccccagtg ctggggtagg

601 agagtctgcc tgttattctg cctctatgca gagaaggagc cccagatcat cttttccatg

661 acaggacagt ttccaagatg ccacctgtac ttggaagaag ccaggttaaa atacttttca

721 agtaaaactt tcttgatatt actctatctt tccccaggag gactgcatta caacaaattc

781 ggacacctgt ggcctctccc ttctatgcaa agcaaaaagc cagcagcagc cccaagctga

841 taagattaat ctaaagagca aattatggtg taatttccta tgctgaaact ttgtagttaa

901 ttttttaaaa aggtttcatt ttcctattgg tctgatttca caggaacatt ttacctgttt

961 gtgaggcatt ttttctcctg gaagagaggt gctgattggc cccaagtgac tgacaatctg

1021 gtgtaacgaa aatttccaat gtaaactcat tttccctcgg tttcagcaat tttaaatcta

1081 tatatagaga tatctttgtc agcattgcat cgttagcttc tcctgataaa ctaattgcct

1141 cacattgtca ctgcaaatcg acacctatta atgggtctca cctcccaact gcttccccct

1201 ctgttcttcc tgctagcatg tgccggcaac tttgtccacg gacacaagtg cgatatcacc

1261 ttacaggaga tcatcaaaac tttgaacagc ctcacagagc agaaggtgag tacctatctg

1321 gcaccatctc tccagatgtt ctggtgatgc tctcagtatt tctaggcatg aaaacgttaa

1381 cagctgctag agaagttgga actggtggtt ggtggcagtc cagggcacac agcgaggctt

1441 ctccctgcca ctcttttttc tgagggtttg taggaagttt cctcagttgg agggagtgag EPI-109 710

1501 agctgctcat caaggacttc tctgtccggt tggaggttaa ctctgtctct tgctctctca 1561 tttctgcctg gaccaagact ctgtgcaccg agttgaccgt aacagacatc tttgctgcct 1621 ccaaggtaag aagccgtccc acggtctgtt ttagcaaatg gggagatcca tccccaaatg 1681 tctgaacaag aaacttgtct aatggaaaac gagcgggccc aaattaactc taaggtgtta 1741 gatgttttca aagaacgaga agtctgatct ttactcttaa gcatgttttg gtctttctgg 1801 tttcacttga tttagaagac atgtaataga aagcttacat gctgtagtcc tgactcagat 1861 cctggtcaaa gaaaagccct cttgggtttt acttagcttt ggcatagtgc ctggaacgta 1921 ggaggcactc aataaatgcc tgttgaatga gagaattttt ctggcccata catttctgaa 1981 aaaccaaata ctctcacaga aacagatatt gagatgacag gttgagggag ctttcatttt 2041 gtctaagaga cttcctatgg caacagaaaa ggtatcgcca gagcccctcc tcttccacag 2101 cctggccacc taacagccct ctggttccgg ggctgccgtc cagagctctc agcttgctct 2161 ggccggccga actcccctcc agctcggtct ggaaccatcc tgctgggcag cgtccagcac 2221 atccctgctt cgggctgcct gggcacctcg cctctctgcc tcctgtgctg cctcaccccc 2281 acccctctat ctgtagtggg agggagatag atttgacagc tgatagtgca ttttctctga 2341 caaacacatg actacagccg tatcaatagt tttgtgcatt tcagttcctg ttttcatgga 2401 aacacacggc tgagaatgaa agccccaaag cctcaatttc acagtggtct cctaactacc 2461 tgctttccat gcaaactagg gagatgatat ggccaggagt gaagccctgt gtgttgggca 2521 gggtcacact ccagcaccca gaccatagaa cagggcccat cctgcttcat gagggaaact 2581 gctcttcggg cctttagctg gactatctca tttcattagt tatcccggga gtccgataca 2641 ggatgagatt ctgaagggca aatacacact tttttttttt ttttgagata gggtcttgtt 2701 ctgtcaccca ggctggagtg cagtggtgcg atttcagctc atagcagcct ccacctccca 2761 ggctcaagct atcttcctac ctcagcctcc caagtagccg ggacgacagg tgtgcaccac 2821 cacgcctggc taatttttgt atttttttgt agagatggag tcttgccatt ttgcccaggc 2881 ttgtctcgaa cttctgggct caagcaatcc gtccacctcg gcctctcaaa gtgctgggat 2941 tagccactgc acctgggcaa cagtttatgt gtgtgtgtgt gtgtgtgtgt atatatgtgt 3001 gtgtgtgtat atatatgtgt gtatgtatat atgtgtatgt atatgtgtgt gtgtgtgtgt 3061 gtgtgtgtgt gtgtataaaa tctccaagtc catccaaccg agatggctcc tactagaagc 3121 caagagtcca ccgggttgag cactgggtct ctggaggcct gtcggactgc tgagaaggct 3181 ctaacaaagc caagggaagg gccacctcac tagaagccag gcctggagga agggtgaggg 3241 ctgagggctg gaggtaagac tgcctgtggt tttagaccca ggctctgcca ctgactagct 3301 gtgtggctgg ccttcagaca tcttcacagc tctctgcacc tcagtttcca catgtgaaga 3361 tatgaaagtg attctgaagg tgattgcaag gttgattgga atccagctct tgagttagtg 3421 caaagtgtta ttgtgagatg atataaccac gattaaaagc aagaacaggt gcagagaagc 3481 gatgattcta agaaggaggg gaccgggttg gaaaggatca aaccatccag gatgccgagt 3541 ctggggcaat ccatctgggc tgtttctgga agacccccgg gtgcaggcca ggacactgct 3601 gccctcccgt ccttaactcc cctcttcact cagtcctcac tcacctccct ctcacacaca 3661 caaacatctc ctagaataat ccccactgcc tgccttcact cttacccgtc tcatttgcct 3721 cccctgaact tcatcctcct ggagttcacg atctcactct tcactctttt cttcccctcg 3781 aagattcagc actgcttact tacatgttaa gatatttcag aacagtgaaa tgttgctatt 3841 ttcaaaaacc tacaaaggtg gtatgcagag gaaaaggtac ttctttgtgt tcccaaagaa 3901 aacatctttc caaaatccag cctattgatt ttatttcttc gggggaacaa gaattttagt 3961 atctctaagt tgggtagcat tctactcttg gcagttgctg gaaagaaggc actggtctag 4021 gtcctgggct tcacaggtaa cacctgtcag ggtgtctatg aagtcaaggc tgtctgagga 4081 acagcaaagt gggaagaagc aagctggctg gctgatgaag ggtttcttgg gtggacaagt 4141 agttggagcg atttcctatt taccaaagag agctaaagtt cataattcta cagagagttc 4201 cataatgaac ctcaaatacc tctgtttttt gaaggagttt ctcatataca gcactagctg 4261 actatcctgg gcaggatggg agataatgaa tgcagtgcca atcgggctgg atttatatgg 4321 tcctagtgag gctggtcaag aaccgagtta gaactctcac agagtcactg cccacagaag 4381 aaatctccca agtggctgtt tcctgacatt cccgggaggc aggcctcctt ctgagtcact 4441 ccctaagcag ttctgaactg tgaggtcagc caggctgtcc aagtgcactc cctgagccac 4501 tggcagacac actcagcagc cagagctaga caggcaggtg gtaggagtcc agggccacgg 4561 cagggatgga gtgtcgcccc ctcgctgcga taccagagca agtaaaacgt taaggccttg 4621 cactaaagct gcccttagga tgcattcttt taaagttttt ccatttaatg cagactcttt 4681 tcaattctta ttttatcctt gtttccttta gaaagtcctt tgaaaaatat ctttagaggg 4741 ttttttccta tactatgtgg ccatatacgg gtcaaaatta agtttaattt ccaggctcca 4801 agccagcgtt tcagaaaaat ctcaccaagg tttgtggtaa aagaagcaaa gggctgactt 4861 tttggttttc ttgaatctca ctgttccctc tgcagcagca tgcatgtctg cccacctcca 4921 gacacacagg caccatctgc cgccccccat cagcccgtgt cccttccacc tcgactcgcc 4981 tacaaagccc agagaggtct gtttcttggc ccccagagcc caaagatact gacacactct 5041 tacatttcca actagaatca ggaacgagga gtgactctca gtcagttcat taagtaaatg 5101 tctttctaac cgctctgccc atgggacatc acgccccaca ggggaaaggg gaagcttctg 5161 tagcctggga ttctggtgcc tcagtctggg tctagacttt cctgaaaaaa cgttaaaata 5221 tgaactgcat tcctagaatt tagcctacat aaataagaga tgaacacaaa gatttctata 5281 gtttactcac tgccgcttat ttacagaagc aaaaatctgc cacgataggg gcctgacaaa 5341 tgacagtacc actgtgcaat gcgtttctac gcagctctca atcccatgtt ctctaatacc 5401 accgaaggct taggaaatgc ttatggtata tgtaaagagt aaagaagtta caaacagtat 5461 caacagttga cccctatttt aaaaagtatt tttgaaaagt gtgacgatat ttaccaaaat 5521 attaacgagc aatagttacc tctggctggt gggatgagtg aatgtatttt tgttgaatat EPI-109 711

5581 atgttacctt tatagtaaat atatgttatc ttgatcatca gaaaaaaaaa tatgtaagaa 5641 cttgaaagct gcttggacag cgctgctgat agaaacccct gagca cttg tcactgttct 5701 tctgattcag agggtctggg tggggcaggg gtggtctgag attcπgtatt tctaagaagc 5761 tcccagtgat gtccatgctg ctgtccatgg accacacttt gagtatcaag ggaccagagc 5821 atgtcggggg agaggctggg gatagctttc tttatctgaa ctggataaag gaactgggct 5881 caagctaaga accctctcca ggttctgcat ctttgttctt cagtgaaaaa tgagaggaca 5941 caccaggcca ggttcagact gagacacaat ccctctcctg ggttcccaat gacttgtctc 6001 ttgtccattc ccttctctaa ggctaagggc cccccaggaa gagccatgtg gccagaccct 6061 cacagttgct ggcattccaa ggagattctc actccgcatc attggtccaa aaggcccctt 6121 acagaagctc tgcccaaggc tcagatcaat ggcacctgct cccagagctc ctctgatctc 6181 ccaggacacc tttccctgat ctgtgcactt atctcttgct gcctggcaaa atgtcttagc 6241 tcctcacttg ggccatgtgc tgctctcctc tcccatgggg agagccacac ggagagtgct 6301 ggccaaagca gcagagttca ggccaaagga tgtgcactca tttattcaac aggcatgcag 6361 gatttccagg gaaagctgga ttttaaaacc tctgggaaca agagcagaac ctgactgaga 6421 gctcatgtgg gcacttttca tagcagaata gctcatgagg tatagagaca cggacgcaga 6481 acgtgggctg tagcgacaga tggtcctgca ttctagtccc cactgrgcct tttcctcatg 6541 ggatgacttt attcaggtac cctttcggca aaatcctcca agagaaagga aactgggagg 6601 ttctggggag aaggctgctg cgtttgcaat tgggagaggt tgttgacaga ggtttatgtc 6661 tgtggcaagc agccttcctt cagtggaata cttgaagaca ggtctgtagt tgagcaaact 6721 cacctccatt tgtcctcctg gaaagaagaa atcaagagga aaaatctctc tcccatcctc 6781 caaatggagc tggcacattg ctatctgtgg catttgtctt tccagaacac aactgagaag 6841 gaaaccttct gcagggctgc gactgtgctc cggcagttct acagccacca tgagaaggac 6901 actcgctgcc tgggtgcgac tgcacagcag ttccacaggc acaagcagct gatccgattc 6961 ctgaaacggc tcgacaggaa cctctggggc ctggcgggct tggtaagctg cactgtattc 7021 ctggcaagcc ggccgcgtgg ctcctggtgg acagcagcct cacttctaaa cactccttag 7081 gagctgcagc acccttggtc aacccattca ttcattcact cattcaataa gtatttgctg 7141 aagttccaca agtgctgggt gtggttctag gtgctgagga cgtgtcacta aagacagcag 7201 gccgagtccc tgttctcatg gaatgttcta atgggagagt tagaaaaaca aacatgtaaa 7261 atgatggcca gcagtgatac gtgctacaaa gaaaaacata gaaataaaga acataagagt 7321 catgggggag ggggctgact taggagctgg tgacattatc tgagcagata tttgaattga 7381 gggagcaggc cacatgacta actagggaga ccattccagg gagaaggagg aggtatgcaa 7441 aggccttagg atggaaatga actaacttcc tgtatttaaa gaccagtagg aaggccagtg 7501 tggctggatc agagtgagtg aggggtagtt tccaggacag cagatcacac aaggccttta 7561 gattccacca cgagtatgga gggaacacct gcagagcttt gggcaggaca aagactgtac 7621 aatctgattt acgtgattta aaagggtcag tctggctact gtgtggtaaa taggctgaaa 7681 gggggaaagc atagaagcaa gatggcctgt tgggaggcta ccacagtaaa ccaggctaga 7741 gatgatggtg gcgtggacag aatgaagcaa gatggcctgt tgggaggcta ccacagtaaa 7801 ccaggctaga gatgatggtg gcgtggacag aatgaagcaa gatggcctgt tgggaggcta 7861 ccacagtaaa ccaggctaga gatgatggtg gcgtggacaa atggagcagt tgaggtgaac 7921 agatttggga tatgactaaa aataaaacca gaagatttgc tgacagatcg gttgtagggg 7981 gtaagataca ggggaggaaa agatgacctc tttgttcctg cccaaacccc tctggcgatg 8041 gtcagtactg tttacagaga gatgaaagac tggcggcaag gcagggctgg aggttcagca 8101 gaagatcaag agttcaattt tgtacatcgt acatgtaagg tggctcttgg atagccaagt 8161 gaaggtgttg agaagatggt tagaaaagtc tggaacttag gggagaggtc agaacttgca 8221 atacaaaaag gagagtcctt agatagatac tgctgaaaat ctgaatgaca gaaagggaga 8281 gatcaaagga ctgagcctga gatcaacaca tggaggtcag gagaggagga tccagccaag 8341 gggcctgagg aggagtgacc agtgaggcag gagaacatgg agagtgggcg gtaccccagg 8401 aagccggtga ggacactcaa ggagggaggg ttgactgtgt caaatgtact gaaaggacag 8461 gtcaggtgag gaccaagaaa ggcccctggg tttggctgat ggaggccatg ggtgaggctg 8521 atgtaaatgg agaggcagga aggaaagccc agctggagtg ggctcaccga ggatagggtg 8581 gcgagaggag acaaagaagg aacagtgagg gcagacaact ctttgaagat gtttagctat 8641 aaggctgcag agaaactgag cccacagctg cagggtggtt atggagtgag ggaagctctt 8701 ttaaggttgg gggtataccc agcatgttaa tgcacctggg ggaatggtcc agtggagcag 8761 gaagaactga agagagcaga aagaggaaga atcattaggg ggcagaagtc cttgtagccc 8821 agagtggatg ttatctaata tcgagtggag gaattaattg gctttagagg agaacaagga 8881 catgtatccc ctctctgggc ctatcacctt gtagacaatg ggataggtca tgggatagga 8941 acttggcaca acacatgttc tctcttttaa ttctctccat tatcttatga agcaggcaag 9001 taggcaaaca attgtcccaa ctttacaaaa gaaactgaag cttttataaa ttaagtagta 9061 catcctaagc aatacaatta ataaatggta gagctgagat tcaaactgaa gcagtggcct 9121 gggggtagca tctggaatcc ttcccacctt tagggctgct gtgctgcggt gctgctgttt 9181 aatggcacag agggccagat gactgaatct ctctcagcag tccaggcagt catgcagaag 9241 gcccagtaga gcaccgggca ggtctgagcc agcatcttca agttccaccc tgtgagcaag 9301 cacttagctg tgacacactt ctcgagagac tggactcccc cccgcgcaac ccacccaaaa 9361 gcagataggt aatggtatac agtaaccatt tctagaagtg taagtagtat gcacccaaaa 9421 taggcaaaac ctgctggcct agtgatagag acaactccca gtcaggctag actggaggcc 9481 ttggttttat aagtgttcag gtgacaagtg ccacagtagg cttgatcaag tagacaggca 9541 ggcaagacaa atgcttacca atgcaagcta atgaaatgtt tcttttgcag aattcctgtc 9601 ctgtgaagga agccaaccag agtacgttgg aaaacttctt ggaaaggcta aagacgatca EPI-109 712

9661 tgagagagaa atattcaaag tgttcgagct gaatatttta atttatgagt ttttgatagc

9721 tttatttttt aagtatttat atatttataa ctcatcataa aataaagtat atatagaatc

9781 taacagcaat ggcatttaat gtattggcta tgtttacttg acaaatgaaa ttatggtttg

9841 caacttttag ggaaatcaat ttagtttacc aagagactat aaatgctatg gagccaaaac

(2) INFORMATION FOR SEQ ID NO: 2543: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10442 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2543:

1 gatcgttagc ttctcctgat aaactaattg cctcacattg tcactgcaaa tcgacaccta 61 ttaatgggtc tcacctccca actgcttccc cctctgttct tcctgctagc atgtgccggc 121 aactttgtcc acggacacaa gtgcgatatc accttacagg agatcatcaa aactttgaac 181 agcctcacag agcagaagac tctgtgcacc gagttgaccg taacagacat ctttgctgcc 241 tccaagaaca caactgagaa ggaaaccttc tgcagggctg cgactgtgct ccggcagttc 301 tacagccacc atgagaagga cactcgctgc ctgggtgcga ctgcacagca gttccacagg 361 cacaagcagc tgatccgatt cctgaaacgg ctcgacagga acctctgggg cctggcgggc 421 ttgaattcct gtcctgtgaa ggaagccaac cagagtacgt tggaaaactt cttggaaagg 481 ctaaagacga tcatgagaga gaaatattca aagtgttcga gctgaatatt ttaatttatg 541 agtttttgat agctttattt tttaagtatt tatatattta taactcatca taaaataaag 601 tatatataga atct

1 gaattcaata aaaaacaagc agggcgcgtg gtggggcact gactaggagg gctgatttgt

61 aagttggtaa gactgtagct ctttttccta attagctgag gatgtgttta ggttccattc

121 aaaaagtggg cattcctggc caggcatggt ggctcacacc tgtaatctca gagctttggg

181 agactgaggt aggaggatca cttgagccca ggaatttgag atgagcctag gcaacatagt

241 gagactctta tctctatcaa aaaataaaaa taaaaatgag ccaggcatgg tgcggtggac

301 cacgcaccta ctgctagggg ggctgaggtg ggaggatcat tgagcctggg aggttgaggc

361 tgcagtgatc cctgatcaaa cattgcattt cagcctgggt gacagagtga gaccctgtct

421 cagaaaaaaa aaaaaaaagt cattcctgaa acctcagaat agacctacct tgccaagggc

481 ttccttatgg gtaaggacct tatggacctg ctgggaccca aactaggcct cacctgatac

541 gacctgtcct tctcaaaaca ctaaacttgg gagaacattg tcccccagtg ctggggtagg

601 agagtctgcc tgttattctg cctctatgca gagaaggagc cccagatcat cttttccatg

661 acaggacagt ttccaagatg ccacctgtac ttggaagaag ccaggttaaa atacttttca

721 agtaaaactt tcttgatatt actctatctt tccccaggag gactgcatta caacaaattc

781 ggacacctgt ggcctctccc ttctatgcaa agcaaaaagc cagcagcagc cccaagctga

841 taagattaat ctaaagagca aattatggtg taatttccta tgctgaaact ttgtagttaa

901 ttttttaaaa aggtttcatt ttcctattgg tctgatttca caggaacatt ttacctgttt

961 gtgaggcatt ttttctcctg gaagagaggt gctgattggc cccaagtgac tgacaatctg

1021 gtgtaacgaa aatttccaat gtaaactcat tttccctcgg tttcagcaat tttaaatcta

1081 tatatagaga tatctttgtc agcattgcat cgttagcttc tcctgataaa ctaattgcct

1141 cacattgtca ctgcaaatcg acacctatta atgggtctca cctcccaact gcttccccct

1201 ctgttcttcc tgctagcatg tgccggcaac tttgtccacg gacacaagtg cgatatcacc

1261 ttacaggaga tcatcaaaac tttgaacagc ctcacagagc agaaggtgag tacctatctg

1321 gcaccatctc tccagatgtt ctggtgatgc tctcagtatt tctaggcatg aaaacgttaa

1381 cagctgctag agaagttgga actggtggtt ggtggcagtc cagggcacac agcgaggctt

1441 ctccctgcca ctcttttttc tgagggtttg taggaagttt cctcagttgg agggagtgag

1501 agctgctcat caaggacttc tctgtccggt tggaggttaa ctctgtctct tgctctctca

1561 tttctgcctg gaccaagact ctgtgcaccg agttgaccgt aacagacatc tttgctgcct

1621 ccaaggtaag aagccgtccc acggtctgtt ttagcaaatg gggagatcca tccccaaatg

1681 tctgaacaag aaacttgtct aatggaaaac gagcgggccc aaattaactc taaggtgtta

1741 gatgttttca aagaacgaga agtctgatct ttactcttaa gcatgttttg gtctttctgg

1801 tttcacttga tttagaagac atgtaataga aagcttacat gctgtagtcc tgactcagat

1861 cctggtcaaa gaaaagccct cttgggtttt acttagcttt ggcatagtgc ctggaacgta

1921 ggaggcactc aataaatgcc tgttgaatga gagaattttt ctggcccata catttctgaa

1981 aaaccaaata ctctcacaga aacagatatt gagatgacag gttgagggag ctttcatttt

2041 gtctaagaga cttcctatgg caacagaaaa ggtatcgcca gagcccctcc tcttccacag

2101 cctggccacc taacagccct ctggttccgg ggctgccgtc cagagctctc agcttgctct

2161 ggccggccga actcccctcc agctcggtct ggaaccatcc tgctgggcag cgtccagcac

2221 ^■ atccctgctt cgggctgcct gggcacctcg cctctctgcc tcctgtgctg cctcaccccc

2281 acccctctat ctgtagtggg agggagatag atttgacagc tgatagtgca ttttctctga

2341 caaacacatg actacagccg tatcaatagt tttgtgcatt tcagttcctg ttttcatgga

2401 aacacacggc tgagaatgaa agccccaaag cctcaatttc acagtggtct cctaactacc

2461 tgctttccat gcaaactagg gagatgatat ggccaggagt gaagccctgt gtgttgggca

2521 gggtcacact ccagcaccca gaccatagaa cagggcccat cctgcttcat gagggaaact

2581 gctcttcggg cctttagctg gactatctca tttcattagt tatcccggga gtccgataca

2641 ggatgagatt ctgaagggca aatacacact tttttttttt ttttgagata gggtcttgtt

2701 ctgtcaccca ggctggagtg cagtggtgcg atttcagctc atagcagcct ccacctccca EPI-109 713

2761 ggctcaagct atcttcctac ctcagcctcc caagtagccg ggacgacagg tgtgcaccac

2821 cacgcctggc taatttttgt atttttttgt agagatggag tcttgccatt ttgcccaggc

2881 ttgtctcgaa cttctgggct caagcaatcc gtccacctcg gcctctcaaa gtgctgggat

2941 tagccactgc acctgggcaa cagtttatgt gtgtgtgtgt gtgtgtgtgt atatatgtgt

3001 gtgtgtgtat atatatgtgt gtatgtatat atgtgtatgt atatgtgtgt gtgtgtgtgt

3061 gtgtgtgtgt gtgtataaaa tctccaagtc catccaaccg agatggctcc tactagaagc

3121 caagagtcca ccgggttgag cactgggtct ctggaggcct gtcggactgc tgagaaggct

3181 ctaacaaagc caagggaagg gccacctcac tagaagccag gcctggagga agggtgaggg

3241 ctgagggctg gaggtaagac tgcctgtggt tttagaccca ggctctgcca ctgactagct

3301 gtgtggctgg ccttcagaca tcttcacagc tctctgcacc tcagtttcca catgtgaaga

3361 tatgaaagtg attctgaagg tgattgcaag gttgattgga atccagctct tgagttagtg

3421 caaagtgtta ttgtgagatg atataaccac gattaaaagc aagaacaggt gcagagaagc

3481 gatgattcta agaaggaggg gaccgggttg gaaaggatca aaccatccag gatgccgagt

3541 ctggggcaat ccatctgggc tgtttctgga agacccccgg gtgcaggcca ggacactgct

3601 gccctcccgt ccttaactcc cctcttcact cagtcctcac tcacctccct ctcacacaca

3661 caaacatctc ctagaataat ccccactgcc tgccttcact cttacccgtc tcatttgcct 3721 cccctgaact tcatcctcct ggagttcacg atctcactct tcactctttt cttcccctcg 3781 aagattcagc actgcttact tacatgttaa gatatttcag aacagtgaaa tgttgctatt 3841 ttcaaaaacc tacaaaggtg gtatgcagag gaaaaggtac ttctttgtgt tcccaaagaa 3901 aacatctttc caaaatccag cctattgatt ttatttcttc gggggaacaa gaattttagt 3961 atctctaagt tgggtagcat tctactcttg gcagttgctg gaaagaaggc actggtctag 4021 gtcctgggct tcacaggtaa cacctgtcag ggtgtctatg aagtcaaggc tgtctgagga 4081 acagcaaagt gggaagaagc aagctggctg gctgatgaag ggtttcttgg gtggacaagt 4141 agttggagcg atttcctatt taccaaagag agctaaagtt cataattcta cagagagttc 4201 cataatgaac ctcaaatacc tctgtttttt gaaggagttt ctcatataca gcactagctg 4261 actatcctgg gcaggatggg agataatgaa tgcagtgcca atcgggctgg atttatatgg 4321 tcctagtgag gctggtcaag aaccgagtta gaactctcac agagtcactg cccacagaag 4381 aaatctccca agtggctgtt tcctgacatt cccgggaggc aggcctcctt ctgagtcact 4441 ccctaagcag ttctgaactg tgaggtcagc caggctgtcc aagtgcactc cctgagccac 4501 tggcagacac actcagcagc cagagctaga caggcaggtg gtaggagtcc agggccacgg 4561 cagggatgga gtgtcgcccc ctcgctgcga taccagagca agtaaaacgt taaggccttg

4621 cactaaagct gcccttagga tgcattcttt taaagttttt ccatttaatg cagactcttt 4681 tcaattctta ttttatcctt gtttccttta gaaagtcctt tgaaaaatat ctttagaggg 4741 ttttttccta tactatgtgg ccatatacgg gtcaaaatta agtttaattt ccaggctcca 4801 agccagcgtt tcagaaaaat ctcaccaagg tttgtggtaa aagaagcaaa gggctgactt 4861 tttggttttc ttgaatctca ctgttccctc tgcagcagca tgcatgtctg cccacctcca 4921 gacacacagg caccatctgc cgccccccat cagcccgtgt cccttccacc tcgactcgcc 4981 tacaaagccc agagaggtct gtttcttggc ccccagagcc caaagatact gacacactct 5041 tacatttcca actagaatca ggaacgagga gtgactctca gtcagttcat taagtaaatg 5101 tctttctaac cgctctgccc atgggacatc acgccccaca ggggaaaggg gaagcttctg 5161 tagcctggga ttctggtgcc tcagtctggg tctagacttt cctgaaaaaa cgttaaaata 5221 tgaactgcat tcctagaatt tagcctacat aaataagaga tgaacacaaa gatttctata 5281 gtttactcac tgccgcttat ttacagaagc aaaaatctgc cacgataggg gcctgacaaa 5341 tgacagtacc actgtgcaat gcgtttctac gcagctctca atcccatgtt ctctaatacc 5401 accgaaggct taggaaatgc ttatggtata tgtaaagagt aaagaagtta caaacagtat 5461 caacagttga cccctatttt aaaaagtatt tttgaaaagt gtgacgatat ttaccaaaat 5521 attaacgagc aatagttacc tctggctggt gggatgagtg aatgtatttt tgttgaatat 5581 atgttacctt tatagtaaat atatgttatc ttgatcatca gaaaaaaaaa tatgtaagaa 5641 cttgaaagct gcttggacag cgctgctgat agaaacccct gagcatcttg tcactgttct 5701 tctgattcag agggtctggg tggggcaggg gtggtctgag attctgtatt tctaagaagc 5761 tcccagtgat gtccatgctg ctgtccatgg accacacttt gagtatcaag ggaccagagc 5821 atgtcggggg agaggctggg gatagctttc tttatctgaa ctggataaag gaactgggct 5881 caagctaaga accctctcca ggttctgcat ctttgttctt cagtgaaaaa tgagaggaca 5941 caccaggcca ggttcagact gagacacaat ccctctcctg ggttcccaat gacttgtctc 6001 ttgtccattc ccttctctaa ggctaagggc cccccaggaa gagccatgtg gccagaccct 6061 cacagttgct ggcattccaa ggagattctc actccgcatc attggtccaa aaggcccctt 6121 acagaagctc tgcccaaggc tcagatcaat ggcacctgct cccagagctc ctctgatctc 6181 ccaggacacc tttccctgat ctgtgcactt atctcttgct gcctggcaaa atgtcttagc 6241 tcctcacttg ggccatgtgc tgctctcctc tcccatgggg agagccacac ggagagtgct 6301 ggccaaagca gcagagttca ggccaaagga tgtgcactca tttattcaac aggcatgcag 6361 gatttccagg gaaagctgga ttttaaaacc tctgggaaca agagcagaac ctgactgaga 6421 gctcatgtgg gcacttttca tagcagaata gctcatgagg tatagagaca cggacgcaga 6481 acgtgggctg tagcgacaga tggtcctgca ttctagtccc cactgtgcct tttcctcatg 6541 ggatgacttt attcaggtac cctttcggca aaatcctcca agagaaagga aactgggagg 6601 ttctggggag aaggctgctg cgtttgcaat tgggagaggt tgttgacaga ggtttatgtc 6661 tgtggcaagc agccttcctt cagtggaata cttgaagaca ggtctgtagt tgagcaaact 6721 cacctccatt tgtcctcctg gaaagaagaa atcaagagga aaaatctctc tcccatcctc 6781 caaatggagc tggcacatt^'g ctatctgtgg catttgtctt tccagaacac aactgagaag EPI-109 714

6841 gaaaccttct gcagggctgc gactgtgctc cggcagttct acagccacca tgagaaggac 6901 actcgctgcc tgggtgcgac tgcacagcag ttccacaggc acaagcagct gatccgattc 6961 ctgaaacggc tcgacaggaa cctctggggc ctggcgggct tggtaagctg cactgtattc 7021 ctggcaagcc ggccgcgtgg ctcctggtgg acagcagcct cacttctaaa cactccttag 7081 gagctgcagc acccttggtc aacccattca ttcattcact cattcaataa gtatttgctg 7141 aagttccaca agtgctgggt gtggttctag gtgctgagga cgtgtcacta aagacagcag 7201 gccgagtccc tgttctcatg gaatgttcta atgggagagt tagaaaaaca aacatgtaaa 7261 atgatggcca gcagtgatac gtgctacaaa gaaaaacata gaaataaaga acataagagt 7321 catgggggag ggggctgact taggagctgg tgacattatc tgagcagata tttgaattga 7381 gggagcaggc cacatgacta actagggaga ccattccagg gagaaggagg aggtatgcaa 7441 aggccttagg atggaaatga actaacttcc tgtatttaaa gaccagtagg aaggccagtg 7501 tggctggatc agagtgagtg aggggtagtt tccaggacag cagatcacac aaggccttta 7561 gattccacca cgagtatgga gggaacacct gcagagcttt gggcaggaca aagactgtac 7621 aatctgattt acgtgattta aaagggtcag tctggctact gtgtggtaaa taggctgaaa 7681 gggggaaagc atagaagcaa gatggcctgt tgggaggcta ccacagtaaa ccaggctaga 7741 gatgatggtg gcgtggacag aatgaagcaa gatggcctgt tgggaggcta ccacagtaaa 7801 ccaggctaga gatgatggtg gcgtggacag aatgaagcaa gatggcctgt tgggaggcta 7861 ccacagtaaa ccaggctaga gatgatggtg gcgtggacaa atggagcagt tgaggtgaac 7921 agatttggga tatgactaaa aataaaacca gaagatttgc tgacagatcg gttgtagggg 7981 gtaagataca ggggaggaaa agatgacctc tttgttcctg cccaaacccc tctggcgatg 8041 gtcagtactg tttacagaga gatgaaagac tggcggcaag gcagggctgg aggttcagca 8101 gaagatcaag agttcaattt tgtacatcgt acatgtaagg tggctcttgg atagccaagt 8161 gaaggtgttg agaagatggt tagaaaagtc tggaacttag gggagaggtc agaacttgca 8221 atacaaaaag gagagtcctt agatagatac tgctgaaaat ctgaatgaca gaaagggaga 8281 gatcaaagga ctgagcctga gatcaacaca tggaggtcag gagaggagga tccagccaag 8341 gggcctgagg aggagtgacc agtgaggcag gagaacatgg agagtgggcg gtaccccagg 8401 aagccggtga ggacactcaa ggagggaggg ttgactgtgt caaatgtact gaaaggacag 8461 gtcaggtgag gaccaagaaa ggcccctggg tttggctgat ggaggccatg ggtgaggctg 8521 atgtaaatgg agaggcagga aggaaagccc agctggagtg ggctcaccga ggatagggtg 8581 gcgagaggag acaaagaagg aacagtgagg gcagacaact ctttgaagat gtttagctat 8641 aaggctgcag agaaactgag cccacagctg cagggtggtt atggagtgag ggaagctctt 8701 ttaaggttgg gggtataccc agcatgttaa tgcacctggg ggaatggtcc agtggagcag 8761 gaagaactga agagagcaga aagaggaaga atcattaggg ggcagaagtc cttgtagccc 8821 agagtggatg ttatctaata tcgagtggag gaattaattg gctttagagg agaacaagga 8881 catgtatccc ctctctgggc ctatcacctt gtagacaatg ggataggtca tgggatagga 8941 acttggcaca acacatgttc tctcttttaa ttctctccat tatcttatga agcaggcaag 9001 taggcaaaca attgtcccaa ctttacaaaa gaaactgaag cttttataaa ttaagtagta 9061 catcctaagc aatacaatta ataaatggta gagctgagat tcaaactgaa gcagtggcct 9121 gggggtagca tctggaatcc ttcccacctt tagggctgct gtgctgcggt gctgctgttt 9181 aatggcacag agggccagat gactgaatct ctctcagcag tccaggcagt catgcagaag 9241 gcccagtaga gcaccgggca ggtctgagcc agcatcttca agttccaccc tgtgagcaag 9301 cacttagctg tgacacactt ctcgagagac tggactcccc cccgcgcaac ccacccaaaa 9361 gcagataggt aatggtatac agtaaccatt tctagaagtg taagtagtat gcacccaaaa 9421 taggcaaaac ctgctggcct agtgatagag acaactccca gtcaggctag actggaggcc 9481 ttggttttat aagtgttcag gtgacaagtg ccacagtagg cttgatcaag tagacaggca 9541 ggcaagacaa atgcttacca atgcaagcta atgaaatgtt tcttttgcag aattcctgtc 9601 ctgtgaagga agccaaccag agtacgttgg aaaacttctt ggaaaggcta aagacgatca 9661 tgagagagaa atattcaaag tgttcgagct gaatatttta atttatgagt ttttgatagc 9721 tttatttttt aagtatttat atatttataa ctcatcataa aataaagtat atatagaatc 9781 taacagcaat ggcatttaat gtattggcta tgtttacttg acaaatgaaa ttatggtttg 9841 caacttttag ggaaatcaat ttagtttacc aagagactat aaatgctatg gagccaaaac

(2) INFORMATION FOR SEQ ID NO: 2544: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3541 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2544:

1 ggcgaatgga gcaggggcgc gcagataatt aaagatttac acacagctgg aagaaatcat

61 agagaagccg ggcgtggtgg ctcatgccta taatcccagc acttttggag gctgaggcgg

121 gcagatcact tgagatcagg agttcgagac cagcctggtg ccttggcatc tcccaatggg

181 gtggctttgc tctgggctcc tgttccctgt gagctgcctg gtcctgctgc aggtggcaag

241 ctctgggaac atgaaggtct tgcaggagcc cacctgcgtc tccgactaca tgagcatctc 301 tacttgcgag tggaagatga atggtcccac caattgcagc accgagctcc gcctgttgta 361 ccagctggtt tttctgctct ccgaagccca cacgtgtatc cctgagaaca acggaggcgc

421 ggggtgcgtg tgccacctgc tcatggatga cgtggtcagt gcggataact atacactgga 481 cctgtgggct gggcagcagc tgctgtggaa gggctccttc aagcccagcg agcatgtgaa 541 acccagggcc ccaggaaacc tgacagttca caccaatgtc tccgacactc tgctgctgac EPI-109 715

601 ctggagcaac ccgtatcccc ctgacaatta cctgtataat catctcacct atgcagtcaa

661 catttggagt gaaaacgacc cggcagattt cagaatctat aacgtgacct acctagaacc

721 ctccctccgc atcgcagcca gcaccctgaa gtctgggatt tcctacaggg cacgggtgag

781 ggcctgggct cagtgctata acaccacctg gagtgagtgg agccccagca ccaagtggca

841 caactcctac agggagccct tcgagcagca cctcctgctg ggcgtcagcg tttcctgcat

901 tgtcatcctg gccgtctgcc tgttgtgcta tgtcagcatc accaagatta agaaagaatg

961 gtgggatcag attcccaacc cagcccgcag ccgcctcgtg gctataataa tccaggatgc

1021 tcaggggtca cagtgggaga agcggtcccg aggccaggaa ccagccaagt gcccacactg

1081 gaagaattgt cttaccaagc tcttgccctg ttttctggag cacaacatga aaagggatga

1141 agatcctcac aaggctgcca aagagatgcc tttccagggc tctggaaaat cagcatggtg

1201 cccagtggag atcagcaaga cagtcctctg gccagagagc atcagcgtgg tgcgatgtgt

1261 ggagttgttt gaggccccgg tggagtgtga ggaggaggag gaggtagagg aagaaaaagg

1321 gagcttctgt gcatcgcctg agagcagcag ggatgacttc caggagggaa gggagggcat

1381 tgtggcccgg ctaacagaga gcctgttcct ggacctgctc ggagaggaga atgggggctt

1441 ttgccagcag gacatggggg agtcatgcct tcttccacct tcgggaagta cgagtgctca

1501 catgccctgg gatgagttcc caagtgcagg gcccaaggag gcacctccct ggggcaagga

1561 gcagcctctc cacctggagc caagtcctcc tgccagcccg acccagagtc cagacaacct

1621 gacttgcaca gagacgcccc tcgtcatcgc aggcaaccct gcttaccgca gcttcagcaa

1681 ctccctgagc cagtcaccgt gtcccagaga gctgggtcca gacccactgc tggccagaca

1741 cctggaggaa gtagaacccg agatgccctg tgtcccccag ctctctgagc caaccactgt

1801 gccccaacct gagccagaaa cctgggagca gatcctccgc cgaaatgtcc tccagcatgg

1861 ggcagctgca gcccccgtct cggcccccac cagtggctat caggagtttg tacatgcggt

1921 ggagcagggt ggcacccagg ccagtgcggt ggtgggcttg ggtcccccag gagaggctgg

1981 ttacaaggcc ttctcaagcc tgcttgccag cagtgctgtg tccccagaga aatgtgggtt

2041 tggggctagc agtggggaag aggggtataa gcctttccaa gacctcattc ctggctgccc

2101 tggggaccct gccccagtcc ctgtcccctt gttcaccttt ggactggaca gggagccacc

2161 tcgcagtccg cagagctcac atctcccaag cagctcccca gagcacctgg gtctggagcc

2221 gggggaaaag gtagaggaca tgccaaagcc cccacttccc caggagcagg ccacagaccc

2281 ccttgtggac agcctgggca gtggcattgt ctactcagcc cttacctgcc acctgtgcgg

2341 ccacctgaaa cagtgtcatg gccaggagga tggtggccag acccctgtca tggccagtcc

2401 ttgctgtggc tgctgctgtg gagacaggtc ctcgccccct acaacccccc tgagggcccc

2461 agacccctct ccaggtgggg ttccactgga ggccagtctg tgtccggcct ccctggcacc

2521 ctcgggcatc tcagagaaga gtaaatcctc atcatccttc catcctgccc ctggcaatgc

2581 tcagagctca agccagaccc ccaaaatcgt gaactttgtc tccgtgggac ccacatacat

2641 gagggtctct taggtgcatg tcctcttgtt gctgagtctg cagatgagga ctagggctta

2701 tccatgcctg ggaaatgcca cctcctggaa ggcagccagg ctggcagatt tccaaaagac

2761 ttgaagaacc atggtatgaa ggtgattggc cccactgacg ttggcctaac actgggctgc

2821 agagactgga ccccgcccag cattgggctg ggctcgccac atcccatgag agtagagggc

2881 actgggtcgc cgtgccccac ggcaggcccc tgcaggaaaa ctgaggccct tgggcacctc

2941 gacttgtgaa cgagttgttg gctgctccct ccacagcttc tgcagcagac tgtccctgtt

3001 gtaactgccc aaggcatgtt ttgcccacca gatcatggcc cacgtggagg cccacctgcc

3061 tctgtctcac tgaactagaa gccgagccta gaaactaaca cagccatcaa gggaatgact

3121 tgggcggcct tgggaaatcg atgagaaatt gaacttcagg gagggtggtc attgcctaga

3181 ggtgctcatt catttaacag agcttcctta ggttgatgct ggaggcagaa tcccggctgt

3241 caaggggtgt tcagttaagg ggagcaacag aggacatgaa aaattgctat gactaaagca

3301 gggacaattt gctgccaaac acccatgccc agctgtatgg ctgggggctc ctcgtatgca

3361 tggaaccccc agaataaata tgctcagcca ccctgtgggc cgggcaatcc agacagcagg

3421 cataaggcac cagttaccct gcatgttggc ccagacctca ggtgctaggg aaggcgggaa

3481 ccttgggttg agtaatgctc gtctgtgtgt tttagtttca tcacctgtta tctgtgtttg

3541 ctgaggagag tggaacagaa ggggtggagt tttgtataaa taaagtttct ttgtctc

(2) INFORMATION FOR SEQ ID NO:2545: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3241 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear .

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2545:

1 ggatcctaat caagacccca gtgaacagaa ctcgaccctg ccaaggcttg gcagtttcca

61 tttcaatcac tgtcttccca ccagtatttt caatttcttt taagacagat taatctagcc

121 acagtcatag tagaacatag ccgatctgaa aaaaacattc ccaatattta tgtattttag

181 cataaaattc tgtttagtgg tctaccttat actttgtttt gcacacatct tttaagagga

241 agttaatttt ctgattttaa gaaatgcaaa tgtggggcaa tgatgtatta acccaaagat

301 tcttcgtaat agaaaatgtt tttaaagggg ggaaacaggg atttttatta ttaaaagata

361 aaagtaaatt tattttttaa gatataaggc attggaaaca tttagtttca cgatatgcca

421 ttattaggca ttctctatct gattgttaga aattattcat ttcctcaaag acagacaata

481 aattgactgg ggacgcagtc ttgtactatg cactttcttt gccaaaggca aacgcagaac

541 gtttcagagc catgaggatg cttctgcatt tgagtttgct agctcttgga gctgcctacg

601 tgtatgccat ccccacagaa attcccacaa gtgcattggt gaaagagacc ttggcactgc EPI-109 716

661 tttctactca tcgaactctg ctgatagcca atgaggtaat tttctttatg attcctacag

721 tctgtaaagt gcataggtaa tcatttgtga tggttccttt actatatata gagatctgtt

781 ataaataata agattctgag cacattagta catgggtgat aactacatca ccagcaaaca

841 ttctgttaaa agttatgaat gctggtgtgc tgtaaaaatg attgtatttc ctttcctctc

901 cagactctga ggattcctgt tcctgtacat aaaaatgtaa gttaaattat gattcagtaa

961 aatgatggca tgaataagta aatttcctgt tttaagctgt aaatcattag ttatcattgg

1021 aactatttaa ttttctatat tttgttttca tatgggtggc tgtgaatgtc tgtacttata

1081 aatatgagga atgacttttt atcaagtaga atcctttaaa caagtggatt aggctctttg

1141 gtgatgttgt tagtttgcct cccaaagagc atcgtgtcag ggattctttc cagaaggatt

1201 ccacactgag tgagaggtgc gtgctagtct ccgtgcagtt ctgactcttt ctcactctaa

1261 cgtgtttctg aaagtattag caactcagaa ttatattttt agaaccatga tcagtagaca

1321 ttaaaatata taacaaatgc cctatattaa taatttctgc atacttaaat aattatgact

1381 atatgatggt gttgtatgca tttgaatatg tcctggtcat attaaaatgt aaaatatata

1441 gttttattag tctaaataga ataaaactac cagctagaac tgtagaaaca cattgatatg

1501 agtttaatgt ataatgcatt acacttccaa aacatttttt tccagttaca taattaagtt

1561 atatccttta taaaactcct cagtaatcat ataagcttca tctacttttt gaaaatttta

1621 tcttaatatg tggtggtttg ttgcctagaa aacaaacaaa aaactctttg gagaagggaa

1681 ctcatgtaaa taccacaaaa caaagcctaa ctttgtggac caaaattgtt ttaataatta

1741 ttttttaatt gatgaattaa aaagtatata tatttattgt gtacaatatg atgttttgaa

1801 gtatgtatac attgcagaat ggacaatgga ccaaattttt ataccttgtc ttgattattt

1861 gcattttaaa aattttcctc atttagcacc aactgtgcac tgaagaaatc tttcagggaa

1921 taggcacact ggagagtcaa actgtgcaag ggggtactgt ggaaagacta ttcaaaaact

1981 tgtccttaat aaagaaatac attgacggcc aaaaagtaag ttacacacat tcaatggaag

2041 ctatatttgt ctggctgtgc ctatttctat ggaattgaca gtttcctgta atacctattg

2101 tcatttttct tttttcacag aaaaagtgtg gagaagaaag acggagagta aaccaattcc

2161 tagactacct gcaagagttt cttggtgtaa tgaacaccga gtggataata gaaagttgag

2221 actaaactgg tttgttgcag ccaaagattt tggaggagaa ggacatttta ctgcagtgag

2281 aatgagggcc aagaaagagt caggccttaa ttttcagtat aatttaactt cagagggaaa

2341 gtaaatattt caggcatact gacactttgc cagaaagcat aaaattctta aaatatattt

2401 cagatatcag aatcattgaa gtattttcct ccaggcaaaa ttgatatact tttttcttat

2461 ttaacttaac attctgtaaa atgtctgtta acttaatagt atttatgaaa tggttaagaa

2521 tttggtaaat tagtatttat ttaatgttat gttgtgttct aataaaacaa aaatagacaa

2581 ctgttcaatt tgctgctggc ctctgtctta gcaattgaag ttagcacagt ccattgagta

2641 catgcccagt ttggaggaag ggtctgagca catgtggctg agcatcccca tttctctgga

2701 gaagtctcaa ggttgcaagg cacaccagag gtggaagtga tctagcagga cttagtgggg

2761 atgtggggag cagggacaca ggcaggaggt gaacctggtt ttctctctac agtatatcca

2821 gaacctggga tggtgcaggg taaatggtag ggaataaatg aatgaatgtg ctttccaaga

2881 ctgattgtag aactaaaatg agttgtaagg cgtcccctgg aagaagggca gtgtgggaac

2941 ctgtaactag gttcctgccc agcctgtgag aagaatttgg cagatcaatc tcattgccag

3001 tatagagagg aagccagaaa ccctctctgc caaggcctgc aggggttctt accccacctg

3061 accctgcacc ataacaaaag gaacagagag acactggtag ggcagtccca ttagaaagac

3121 tgagttccgt attcccgggg gcagggcagc accaggccgc acaacactcc attctgcctg

3181 cttatggcta tcagtagcat cactagagat tcttctgttt gagaaaactt ctcaaggatc 3241 c

(2) INFORMATION FOR SEQ ID NO: 2546: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 781 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2546:

1 atgcactttc tttgccaaag gcaaacgcag aacgtttcag agccatgagg atgcttctgc

61 atttgagttt gctagctctt ggagctgcct acgtgtatgc catccccaca gaaattccca

121 caagtgcatt ggtgaaagag accttggcac tgctttctac tcatcgaact ctgctgatag

181 ccaatgagac tctgaggatt cctgttcctg tacataaaaa tcaccaactg tgcactgaag

241 aaatctttca gggaataggc acactggaga gtcaaactgt gcaagggggt actgtggaaa

301 gactattcaa aaacttgtcc ttaataaaga aatacattga cggccaaaaa aaaaagtgtg

361 gagaagaaag acggagagta aaccaattcc tagactacct gcaagagttt cttggtgtaa

421 tgaacaccga gtggataata gaaagttgag actaaactgg tttgttgcag ccaaagattt

481 tggaggagaa ggacatttta ctgcagtgag aatgagggcc aagaaagagt caggccttaa

541 ttttcaatat aatttaactt cagagggaaa gtaaatattt caggcatact gacactttgc

601 cagaaagcat aaaattctta aaatatattt cagatatcag aatcattgaa gtattttcct

661 ccaggcaaaa ttgatatact tttttcttat ttaacttaac attctgtaaa atgtctgtta

721 acttaatagt atttatgaaa tggttaagaa tttggtaaat tagtatttat ttaatgttat

781 gttgtgttct aataaaacaa aaatagacaa ctgttc

(2) INFORMATION FOR SEQ ID NO: 2547: (i) SEQUENCE CHARACTERISTICS: EPI-109 717

(A) LENGTH: 4022 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2547:

1 ggatcctaat caagacccca gtgaacagaa ctcgaccctg ccaaggcttg gcagtttcca

61 tttcaatcac tgtcttccca ccagtatttt caatttcttt taagacagat taatctagcc

121 acagtcatag tagaacatag ccgatctgaa aaaaacattc ccaatattta tgtattttag

181 cataaaattc tgtttagtgg tctaccttat actttgtttt gcacacatct tttaagagga

241 agttaatttt ctgattttaa gaaatgcaaa tgtggggcaa tgatgtatta acccaaagat

301 tcttcgtaat agaaaatgtt tttaaagggg ggaaacaggg atttttatta ttaaaagata

361 aaagtaaatt tattttttaa gatataaggc attggaaaca tttagtttca cgatatgcca

421 ttattaggca ttctctatct gattgttaga aattattcat ttcctcaaag acagacaata

481 aattgactgg ggacgcagtc ttgtactatg cactttcttt gccaaaggca aacgcagaac

541 gtttcagagc catgaggatg cttctgcatt tgagtttgct agctcttgga gctgcctacg

601 tgtatgccat ccccacagaa attcccacaa gtgcattggt gaaagagacc ttggcactgc

661 tttctactca tcgaactctg ctgatagcca atgaggtaat tttctttatg attcctacag

721 tctgtaaagt gcataggtaa tcatttgtga tggttccttt actatatata gagatctgtt

781 ataaataata agattctgag cacattagta catgggtgat aactacatca ccagcaaaca

841 ttctgttaaa agttatgaat gctggtgtgc tgtaaaaatg attgtatttc ctttcctctc

901 cagactctga ggattcctgt tcctgtacat aaaaatgtaa gttaaattat gattcagtaa

961 aatgatggca tgaataagta aatttcctgt tttaagctgt aaatcattag ttatcattgg

1021 aactatttaa ttttctatat tttgttttca tatgggtggc tgtgaatgtc tgtacttata

1081 aatatgagga atgacttttt atcaagtaga atcctttaaa caagtggatt aggctctttg

1141 gtgatgttgt tagtttgcct cccaaagagc atcgtgtcag ggattctttc cagaaggatt

1201 ccacactgag tgagaggtgc gtgctagtct ccgtgcagtt ctgactcttt ctcactctaa

1261 cgtgtttctg aaagtattag caactcagaa ttatattttt agaaccatga tcagtagaca

1321 ttaaaatata taacaaatgc cctatattaa taatttctgc atacttaaat aattatgact

1381 atatgatggt gttgtatgca tttgaatatg tcctggtcat attaaaatgt aaaatatata

1441 gttttattag tctaaataga ataaaactac cagctagaac tgtagaaaca cattgatatg

1501 agtttaatgt ataatgcatt acacttccaa aacatttttt tccagttaca taattaagtt

1561 atatccttta taaaactcct cagtaatcat ataagcttca tctacttttt gaaaatttta

1621 tcttaatatg tggtggtttg ttgcctagaa aacaaacaaa aaactctttg gagaagggaa

1681 ctcatgtaaa taccacaaaa caaagcctaa ctttgtggac caaaattgtt ttaataatta

1741 ttttttaatt gatgaattaa aaagtatata tatttattgt gtacaatatg atgttttgaa

1801 gtatgtatac attgcagaat ggacaatgga ccaaattttt ataccttgtc ttgattattt

1861 gcattttaaa aattttcctc atttagcacc aactgtgcac tgaagaaatc tttcagggaa

1921 taggcacact ggagagtcaa actgtgcaag ggggtactgt ggaaagacta ttcaaaaact

1981 tgtccttaat aaagaaatac attgacggcc aaaaagtaag ttacacacat tcaatggaag

2041 ctatatttgt ctggctgtgc ctatttctat ggaattgaca gtttcctgta atacctattg

2101 tcatttttct tttttcacag aaaaagtgtg gagaagaaag acggagagta aaccaattcc

2161 tagactacct gcaagagttt cttggtgtaa tgaacaccga gtggataata gaaagttgag

2221 actaaactgg tttgttgcag ccaaagattt tggaggagaa ggacatttta ctgcagtgag

2281 aatgagggcc aagaaagagt caggccttaa ttttcagtat aatttaactt cagagggaaa

2341 gtaaatattt caggcatact gacactttgc cagaaagcat aaaattctta aaatatattt

2401 cagatatcag aatcattgaa gtattttcct ccaggcaaaa ttgatatact tttttcttat

2461 ttaacttaac attctgtaaa atgtctgtta acttaatagt atttatgaaa tggttaagaa

2521 tttggtaaat tagtatttat ttaatgttat gttgtgttct aataaaacaa aaatagacaa

2581 ctgttcaatt tgctgctggc ctctgtctta gcaattgaag ttagcacagt ccattgagta

2641 catgcccagt ttggaggaag ggtctgagca catgtggctg agcatcccca tttctctgga

2701 gaagtctcaa ggttgcaagg cacaccagag gtggaagtga tctagcagga cttagtgggg

2761 atgtggggag cagggacaca ggcaggaggt gaacctggtt ttctctctac agtatatcca

2821 gaacctggga tggtgcaggg taaatggtag ggaataaatg aatgaatgtg ctttccaaga

2881 ctgattgtag aactaaaatg agttgtaagg cgtcccctgg aagaagggca gtgtgggaac

2941 ctgtaactag gttcctgccc agcctgtgag aagaatttgg cagatcaatc tcattgccag

3001 tatagagagg aagccagaaa ccctctctgc caaggcctgc aggggttctt accccacctg

3061 accctgcacc ataacaaaag gaacagagag acactggtag ggcagtccca ttagaaagac

3121 tgagttccgt attcccgggg gcagggcagc accaggccgc acaacactcc attctgcctg

3181 cttatggcta tcagtagcat cactagagat tcttctgttt gagaaaactt ctcaaggatc

3241 c

1 atgcactttc tttgccaaag gcaaacgcag aacgtttcag agccatgagg atgcttctgc

61 atttgagttt gctagctctt ggagctgcct acgtgtatgc catccccaca gaaattccca

121 caagtgcatt ggtgaaagag accttggcac tgctttctac tcatcgaact ctgctgatag

181 ccaatgagac tctgaggatt cctgttcctg tacataaaaa tcaccaactg tgcactgaag

241 aaatctttca gggaataggc acactggaga gtcaaactgt gcaagggggt actgtggaaa

301 gactattcaa aaacttgtcc ttaataaaga aatacattga cggccaaaaa aaaaagtgtg

361 gagaagaaag acggagagta aaccaattcc tagactacct gcaagagttt cttggtgtaa

421 tgaacaccga gtggataata gaaagttgag actaaactgg tttgttgcag ccaaagattt

481 tggaggagaa ggacatttta ctgcagtgag aatgagggcc aagaaagagt caggccttaa EPI-109 718

541 ttttcaatat aatttaactt cagagggaaa gtaaatattt caggcatact gacactttgc

601 cagaaagcat aaaattctta aaatatattt cagatatcag aatcattgaa gtattttcct

661 ccaggcaaaa ttgatatact tttttcttat ttaacttaac attctgtaaa atgtctgtta

721 acttaatagt atttatgaaa tggttaagaa tttggtaaat tagtatttat ttaatgttat

781 gttgtgttct aataaaacaa aaatagacaa ctgttc

(2) INFORMATION FOR SEQ ID NO: 2548: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1981 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2548:

1 tagatgctgg ggttgcagcc acgagcatag acacgacaga cacggtcctc gccatcttct

61 gttgagtact ggtcggaaca agaggatcgt ctgtagacag gatatgatca tcgtggcgca

121 tgtattactc atccttttgg gggccactga gatactgcaa gctgacttac ttcctgatga

181 aaagatttca cttctcccac ctgtcaattt caccattaaa gttactggtt tggctcaagt

241 tcttttacaa tggaaaccaa atcctgatca agagcaaagg aatgttaatc tagaatatca

301 agtgaaaata aacgctccaa aagaagatga ctatgaaacc agaatcactg aaagcaaatg

361 tgtaaccatc ctccacaaag gcttttcagc aagtgtgcgg accatcctgc agaacgacca

421 ctcactactg gccagcagct gggcttctgc tgaacttcat gccccaccag ggtctcctgg

481 aacctcaatt gtgaatttaa cttgcaccac aaacactaca gaagacaatt attcacgttt

541 aaggtcatac caagtttccc ttcactgcac ctggcttgtt ggcacagatg cccctgagga

601 cacgcagtat tttctctact ataggtatgg ctcttggact gaagaatgcc aagaatacag

661 caaagacaca ctggggagaa atatcgcatg ctggtttccc aggactttta tcctcagcaa

721 agggcgtgac tggcttgcgg tgcttgttaa cggctccagc aagcactctg ctatcaggcc

781 ctttgatcag ctgtttgccc ttcacgccat tgatcaaata aatcctccac tgaatgtcac

841 agcagagatt gaaggaactc gtctctctat ccaatgggag aaaccagtgt ctgcttttcc

901 aatccattgc tttgattatg aagtaaaaat acacaataca aggaatggat atttgcagat

961 agaaaaattg atgaccaatg cattcatctc aataattgat gatctttcta agtacgatgt

1021 tcaagtgaga gcagcagtga gctccatgtg cagagaggca gggctctgga gtgagtggag

1081 ccaacctatt tatgtgggaa atgatgaaca caagcccttg agagagtggt ttgtcattgt

1141 gattatggca accatctgct tcatcttgtt aattctctcg cttatctgta aaatatgtca

1201 tttatggatc aagttgtttc caccaattcc agcaccaaaa agtaatatca aagatctctt

1261 tgtaaccact aactatgaga aagctggaat ttaaattcaa gcatgtttta acttttggtt

1321 taaggtactt gggtgtacct ggcagtgttg taagctcttt acattaatta attaactctc

1381 taggtactgt tatcttcatt ttataaacaa ggcagctgaa gttgagagaa ataagtaacc

1441 tgtcctaggt cacacaatta ggaaatgaca gatctggcag tctatttcca ggcagtctat

1501 ttccacgagg tcatgagtgc gaaagaggga ctaggggaag aatgattaac tccagggagc

1561 tgacttttct agtgtgctta cctgttttgc atctctcaag gatgtgccat gaagctgtag

1621 ccaggtggaa ttgtaccaca gccctgacat gaacacctga tggcagctgc tgggttggag

1681 cctagacaaa aacatgaaga accatggctg ctgcctgagc ccatcgtgct gtaattatag

1741 aaaaccttct aagggaagaa tatgctgata tttttcagat aagtacccct tttataaaaa

1801 tcctccaagt tagccctcga ttttccatgt aaggaaacag aggctttgag ataatgtctg

1861 tctcctaagg gacaaagcca ggacttgatc ctgtcttaaa aatgcaaaat gtagtacttc

1921 ttccatcaaa ggtagacatg cactaaggga caggttttgg cttggtatca gaatacattt

1981 ttaaaagctg tgtaagaatt gaacgggctg tactaggggg tata

(2) INFORMATION FOR SEQ ID NO: 2549: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 901 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2549:

1 gatctttcta agtacgatgt tcaagtgaga gcagcagtga gctccatgtg cagagaggca

61 gggctctgga gtgagtggag ccaacctatt tatgtgggaa atgatgaaca caagcccttg

121 agagagtggt ttgtcattgt gattatggca accatctgct tcatcttgtt aattctctcg

181 cttatctgta aaatatgtca tttatggatc aagttgtttc caccaattcc agcaccaaaa

241 agtaatatca aagatctctt tgtaaccact aactatgagg tcctctgcat tttcatatac

301 atcttagatt cggctgacaa ttttctacaa aaaaagaaag ctgggtccag tgagacggaa

361 attgaagtca tctgttatat agagaagcct ggagttgaga ccctggagga ttctgtgttt

421 tgactgtcac tttggcatcc tctgatgaac tcacacatgc ctcagtgcct cagtgaaaag

481 aacagggatg ctggctcttg gctaagaggt gttcagaatt taggcaacac tcaatttacc

541 tgcgaagcaa tacacccaga cacaccagtc ttgtatctct taaaagtatg gatgcttcat

601 ccaaatcgcc tcacctacag cagggaagtt gactcatcca agcattttgc catgtttttt

661 ctccccatgc cgtacagggt agcacctcct cacctgccaa tctttgcaat ttgcttgact

721 cacctcagac ttttcattca caacagacag cttttaaggc taacgtccag ctgtatttac EPI-109 719

781 ttctggctgt gcccgtttgg ctgtttaagc tgccaattgt agcactcagc taccatctga 841 ggaagaaagc attttgcatc agcctggagt gaaccatgaa cttggattca agactgtctt 901 ttctatagca agtgagagcc acaaattcct c

(2) INFORMATION FOR SEQ ID NO: 2550: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1321 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2550:

1 ccgctgcttc tcatcgcatg gccaccgcat ttctcaggcc aggcacartg agcattggtc

61 ctgtgcctga cgctatgcta gatgctgggg ttgcagccac gagcatagac acgacagaca

121 cggtcctcgc catcttctgt tgagtactgg tcggaacaag aggatcgtct gtagacaggc

181 tacagattgt tttagattga agtttcctgt catgttcact catctttaaa tcctcatagt

241 aaaaaggata tgatcatcgt ggcgcatgta ttactcatcc ttttgggggc cactgagata

301 ctgcaagctg acttacttcc tgatgaaaag atttcacttc tcccacctgt caatttcacc

361 attaaagtta ctggtttggc tcaagttctt ttacaatgga aaccaaatcc tgatcaagag

421 caaaggaatg ttaatctaga atatcaagtg aaaataaacg ctccaaaaga agatgactat

481 gaaaccagaa tcactgaaag caaatgtgta accatcctcc acaaaggctt ttcagcaagt

541 gtgcggacca tcctgcagaa cgaccactca ctactggcca gcagctgggc ttctgctgaa

601 cttcatgccc caccagggtc tcctggaacc tcaattgtga atttaacttg caccacaaac

661 actacagaag acaattattc acgtttaagg tcataccaag tttcccttca ctgcacctgg

721 cttgttggca cagatgcccc tgaggacacg cagtattttc tctactatag gtatggctct

781 tggactgaag aatgccaaga atacagcaaa gacacactgg ggagaaatat cgcatgctgg

841 tttcccagga cttttatcct cagcaaaggg cgtgactggc tttcggtgct tgttaacggc

901 tccagcaagc actctgctat caggcccttt gatcagctgt ttgcccttca cgccattgat

961 caaataaatc ctccactgaa tgtcacagca gagattgaag gaactcgtct ctctatccaa

1021 tgggagaaac cagtgtctgc ttttccaatc cattgctttg attatgaagt aaaaatacac

1081 aatacaagga atggatattt gcagatagaa aaattgatga ccaatgcatt catctcaata

1141 attgatgatc tttctaagta cgatgttcaa gtgagagcag cagtgagctc catgtgcaga

1201 gaggcagggc tctggagtga gtggagccaa cctatttatg tggggttctc aagataaagg

1261 agataacatc cagctttcct gccccacacc gtatctgaaa taaaaacaac agcagggata

1321 gcagatt

(2) INFORMATION FOR SEQ ID NO: 2551: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1621 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(χi)SEQUENCE DESCRIPTION: SEQ ID NO:2551:

1 ccgctgcttc tcatcgcatg gccaccgcat ttctcaggcc aggcacattg agcattggtc

61 ctgtgcctga cgctatgcta gatgctgggg ttgcagccac gagcatagac acgacagaca

121 cggtcctcgc catcttctgt tgagtactgg tcggaacaag aggatcgtct gtagacaggc

181 tacagattgt tttagattga agtttcctgt catgttcact catctttaaa tcctcatagt

241 aaaaaggata tgatcatcgt ggcgcatgta ttactcatcc ttttgggggc cactgagata

301 ctgcaagctg acttacttcc tgatgaaaag atttcacttc tcccacctgt caatttcacc

361 attaaagtta ctggtttggc tcaagttctt ttacaatgga aaccaaatcc tgatcaagag

421 caaaggaatg ttaatctaga atatcaagtg aaaataaacg ctccaaaaga agatgactat

481 gaaaccagaa tcactgaaag caaatgtgta accatcctcc acaaaggctt ttcagcaagt

541 gtgcggacca tcctgcagaa cgaccactca ctactggcca gcagctgggc ttctgctgaa

601 cttcatgccc caccagggtc tcctggaacc tcaattgtga atttaacttg caccacaaac

661 actacagaag acaattattc acgtttaagg tcataccaag tttcccttca ctgcacctgg

721 cttgttggca cagatgcccc tgaggacacg cagtattttc tctactatag gtatggctct

781 tggactgaag aatgccaaga atacagcaaa gacacactgg ggagaaatat cgcatgctgg

841 tttcccagga cttttatcct cagcaaaggg cgtgactggc tttcggtgct tgttaacggc

901 tccagcaagc actctgctat caggcccttt gatcagctgt ttgcccttca cgccattgat

961 caaataaatc ctccactgaa tgtcacagca gagattgaag gaactcgtct ctctatccaa

1021 tgggagaaac cagtgtctgc ttttccaatc cattgctttg attatgaagt aaaaatacac

1081 aatacaagga atggatattt gcagatagaa aaattgatga ccaatgcatt catctcaata

1141 attgatgatc tttctaagta cgatgttcaa gtgagagcag cagtgagctc catgtgcaga

1201 gaggcagggc tctggagtga gtggagccaa cctatttatg tgggtaagta gcttatgttt

1261 attttacatt ggcagccttc cttgtgatca aaaaaggtaa tcccagaaac gtacccgttc

1321 actcgtgggt cttaaaatgg tttcatatct ctattgtgac taattttctc tcggtctact

1381 gccttttcaa tcaggaatag atttgccatg aagccagtga agtttttaag tgtctaggct

1441 tctcattagt gccaactctc ctagacctgg tgcctgtttt ttttccaagt tttgtttcta

1501 cttctatcca ttttttaaat taaacttttt attttgaaat aattatcaca ctcacaagct

1561 gtgggaagaa ataatagaga tcctgtgtct ctttcatcca gttttcctca agggtaacat EPI-109 720

1621 cttacaaaac tatagtacaa tagtggaata gaatatttgg tgtt

(2) INFORMATION FOR SEQ ID NO: 2552: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1981 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2552:

1 ccgctgcttc tcatcgcatg gccaccgcat ttctcaggcc aggcacattg agcattggtc

61 ctgtgcctga cgctatgcta gatgctgggg ttgcagccac gagcatagac acgacagaca

121 cggtcctcgc catcttctgt tgagtactgg tcggaacaag aggatcgtct gtagacaggc

181 tacagattgt tttagattga agtttcctgt catgttcact catctttaaa tcctcatagt

241 aaaaaggata tgatcatcgt ggcgcatgta ttactcatcc ttttgggggc cactgagata

301 ctgcaagctg acttacttcc tgatgaaaag atttcacttc tcccacctgt caatttcacc

361 attaaagtta ctggtttggc tcaagttctt ttacaatgga aaccaaatcc tgatcaagag

421 caaaggaatg ttaatctaga atatcaagtg aaaataaacg ctccaaaaga agatgactat

481 gaaaccagaa tcactgaaag caaatgtgta accatcctcc acaaaggctt ttcagcaagt

541 gtgcggacca tcctgcagaa cgaccactca ctactggcca gcagctgggc ttctgctgaa

601 cttcatgccc caccagggtc tcctggaacc tcaattgtga atttaacttg caccacaaac

661 actacagaag acaattattc acgtttaagg tcataccaag tttcccttca ctgcacctgg

721 cttgttggca cagatgcccc tgaggacacg cagtattttc tctactatag gtatggctct

781 tggactgaag aatgccaaga atacagcaaa gacacactgg ggagaaatat cgcatgctgg

841 tttcccagga cttttatcct cagcaaaggg cgtgactggc tttcggtgct tgttaacggc

901 tccagcaagc actctgctat caggcccttt gatcagctgt ttgcccttca cgccattgat

961 caaataaatc ctccactgaa tgtcacagca gagattgaag gaactcgtct ctctatccaa

1021 tgggagaaac cagtgtctgc ttttccaatc cattgctttg attatgaagt aaaaatacac

1081 aatacaagga atggatattt gcagatagaa aaattgatga ccaatgcatt catctcaata

1141 attgatgatc tttctaagta cgatgttcaa gtgagagcag cagtgagctc catgtgcaga

1201 gaggcagggc tctggagtga gtggagccaa cctatttatg tgggaaatga tgaacacaag

1261 cccttgagag agtggtttgt cattgtgatt atggcaacca tctgcttcat cttgttaatt

1321 ctctcgctta tctgtaaaat atgtcattta tggatcaagt tgtttccacc aattccagca

1381 ccaaaaagta atatcaaaga tctctttgta accactaact atgagaaagc tgggtccagt

1441 gagacggaaa ttgaagtcat ctgttatata gagaagcctg gagttgagac cctggaggat

1501 tctgtgtttt gactgtcact ttggcatcct ctgatgaact cacacatgcc tcagtgcctc

1561 agtgaaaaga acagggatgc tggctcttgg ctaagaggtg ttcagaattt aggcaacact

1621 caatttacct gcgaagcaat acacccagac acaccagtct tgtatctctt aaaagtatgg

1681 atgcttcatc caaatcgcct cacctacagc agggaagttg actcatccaa gcattttgcc

1741 atgttttttc tccccatgcc gtacagggta gcacctcctc acctgccaat ctttgcaatt

1801 tgcttgactc acctcagact ttcattcaca acagacagct tttaaggcta acgtccagct

1861 gtatttactt ctggctgtgc cgtttggctg tttaagctgc caattgtagc actcagctac

1921 catctgagga agaaagcatt ttgcatcagc ctggagtgaa ccatgaactt ggattcaaga

1981 ctgtcttttc tatagcaa

(2) INFORMATION FOR SEQ ID NO: 2553: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1381 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2553:

1 gtcttttgaa aggatctgcc gctgcttctc atcgcatggc caccgcattt ctcaggccag 61 gcacattgag cattggtcct gtgcctgacg ctatgctaga tgctggggtt gcagccacga 121 gcatagacac gacagacacg gtcctcgcca tcttctgttg agtactggtc ggaacaagag 181 gatcgtctgt agacaggata tgatcatcgt ggcgcatgta ttactcatcc ttttgggggc 241 cactgagata ctgcaagctg acttacttcc tgatgaaaag atttcacttc tcccacctgt 301 caatttcacc attaaagtta ctggtttggc tcaagttctt ttacaatgga aaccaaatcc 361 tgatcaagag caaaggaatg ttaatctaga atatcaagtg aaaataaacg ctccaaaaga 421 agatgactat gaaaccagaa tcactgaaag caaatgtgta accatcctcc acaaaggctt 481 ttcagcaagt gtgcggacca tcctgcagaa cgaccactca ctactggcca gcagctgggc 541 ttctgctgaa cttcatgccc caccagggtc tcctggaacc tcaattgtga atttaacttg 601 caccacaaac actacagaag acaattattc acgtttaagg tcataccaag tttcccttca 661 ctgcacctgg cttgttggca cagatgcccc tgaggacacg cagtattttc tctactatag 721 gtatggctct tggactgaag aatgccaaga atacagcaaa gacacactgg ggagaaatat 781 cgcatgctgg tttcccagga cttttatcct cagcaaaggg cgtgactggc ttgcggtgct 841 tgttaacggc tccagcaagc actctgctat caggcccttt gatcagctgt ttgcccttca 901 cgccattgat caaataaatc ctccactgaa tgtcacagca gagattgaag gaactcgtct 961 ctctatccaa tgggagaaac cagtgtctgc ttttccaatc cattgctttg attatgaagt 1021 aaaaatacac aatacaagga atggatattt gcagatagaa aaattgatga ccaatgcatt EPI-109 721

1081 catctcaata attgatgatc tttctaagta cgatgttcaa gtgagagcag cagtgagctc 1141 catgtgcaga gaggcagggc tctggagtga gtggagccaa cctatttatg tgggtaagta 1201 gcttatgttt attttacatt ggcagccttc cttgtgatca aaaaaggtaa tcccagaaac 1261 gtacccgttc actcgtgggt cttaaaatgg tttcatatct ctattgtgac taattttctc 1321 tcggtctact gccttttcaa tcaggaatag atttgccatg aagccagtga agtttttaag 1381 tgtctaggct tctcattagc gccac

(2) INFORMATION FOR SEQ ID NO:2554: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1981 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi)SEQUENCE DESCRIPTION: SEQ ID NO:2554:

1 cggtcctcgc catcttctgt tgagtactgg tcggaacaag aggatcgtct gtagacagga

61 tatgatcatc gtggcgcatg tattactcat ccttttgggg gccactgaga tactgcaagc

121 tgacttactt cctgatgaaa agatttcact tctcccacct gtcaatttca ccattaaagt

181 tactggtttg gctcaagttc ttttacaatg gaaaccaaat cctgatcaag agcaaaggaa

241 tgttaatcta gaatatcaag tgaaaataaa cgctccaaaa gaagatgact atgaaaccag

301 aatcactgaa agcaaatgtg taaccatcct ccacaaaggc ttttcagcaa gtgtgcggac

361 catcctgcag aacgaccact cactactggc cagcagctgg gcttctgctg aacttcatgc

421 cccaccaggg tctcctggaa cctcagttgt gaatttaact tgcaccacaa acactacaga

481 agacaattat tcacgtttaa ggtcatacca agtttccctt cactgcacct ggcttgttgg

541 cacagatgcc cctgaggaca cgcagtattt tctctactat aggtatggct cttggactga

601 agaatgccaa gaatacagca aagacacact ggggagaaat atcgcatgct ggtttcccag

661 gacttttatc ctcagcaaag ggcgtgactg gcttgcggtg cttgttaacg gctccagcaa

721 gcactctgct atcaggccct ttgatcagct gtttgccctt cacgccattg atcaaataaa

781 tcctccactg aatgtcacag cagagattga aggaactcgt ctctctatcc aatgggagaa

841 accagtgtct gcttttccaa tccattgctt tgattatgaa gtaaaaatac acaatacaag

901 gaatggatat ttgcagatag aaaaattgat gaccaatgca ttcatctcaa taattgatga

961 tctttctaag tacgatgttc aagtgagagc agcagtgagc tccatgtgca gagaggcagg

1021 gctctggagt gagtggagcc aacctattta tgtgggaaat gatgaacaca agcccttgag

1081 agagtggttt gtcattgtga ttatggcaac catctgcttc atcttgttaa ttctctcgct

1141 tatctgtaaa atatgtcatt tatggatcaa gttgtttcca ccaattccag caccaaaaag

1201 taatatcaaa gatctctttg taaccactaa ctatgagaaa gctgggtcca gtgagacgga

1261 aattgaagtc atctgttata tagagaagcc tggagttgag accctggagg attctgtgtt

1321 ttgactgtca ctttggcatc ctctgatgaa ctcacacatg cctcagtgcc tcagtgaaaa

1381 gaacagggat gctggctctt ggctaagagg tgttcagaat ttaggcaaca ctcaatttac

1441 ctgcgaagca atacacccag acacaccagt cttgtatctc ttaaaagtat ggatgcttca

1501 tccaaatcgc ctcacctaca gcagggaagt tgactcatcc aagcattttg ccatgttttt

1561 tctccccatg ccgtacaggg tagcacctcc tcacctgcca atctttgcaa tttgcttgac

1621 tcacctcaga cttttcattc acaacagaca gcttttaagg ctaacgtcca gctgtattta

1681 cttctggctg tgcccgtttg gctgtttaag ctgccaattg tagcactcag ctaccatctg

1741 aggaagaaag cattttgcat cagcctggag tgaatcatga acttggattc aagactgtct

1801 tttctatagc aagtgagagc cacaaattcc tcacccccct acattctaga atgatctttt

1861 tctaggtaga ttgtgtatgt gtgtgtatga gagagagaga gagagagaga gagagagaga

1921 gagaaattat ctcaagctcc agaggcctga tccaggatac atcatttgaa accaactaat

1981 ttaaaagcat aatagagcta atatat

(2) INFORMATION FOR SEQ ID NO: 2555: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11167 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2555:

1 tagatgctgg ggttgcagcc acgagcatag acacgacaga cacggtcctc gccatcttct

61 gttgagtact ggtcggaaca agaggatcgt ctgtagacag gatatgatca tcgtggcgca

121 tgtattactc atccttttgg gggccactga gatactgcaa gctgacttac ttcctgatga

181 aaagatttca cttctcccac ctgtcaattt caccattaaa gttactggtt tggctcaagt

241 tcttttacaa tggaaaccaa atcctgatca agagcaaagg aatgttaatc tagaatatca

301 agtgaaaata aacgctccaa aagaagatga ctatgaaacc agaatcactg aaagcaaatg

361 tgtaaccatc ctccacaaag gcttttcagc aagtgtgcgg accatcctgc agaacgacca

421 ctcactactg gccagcagct gggcttctgc tgaacttcat gccccaccag ggtctcctgg

481 aacctcaatt gtgaatttaa cttgcaccac aaacactaca gaagacaatt attcacgttt

541 aaggtcatac caagtttccc ttcactgcac ctggcttgtt ggcacagatg cccctgagga

601 cacgcagtat tttctctact ataggtatgg ctcttggact gaagaatgcc aagaatacag

661 caaagacaca ctggggagaa atatcgcatg ctggtttccc aggactttta tcctcagcaa

721 agggcgtgac tggcttgcgg tgcttgttaa cggctccagc aagcactctg ctatcaggcc EPI-109 722

781 ctttgatcag ctgtttgccc ttcacgccat tgatcaaata aatcctccac tgaatgtcac

841 agcagagatt gaaggaactc gtctctctat ccaatgggag aaaccagtgt ctgcttttcc

901 aatccattgc tttgattatg aagtaaaaat acacaataca aggaatggat atttgcagat

961 agaaaaattg atgaccaatg cattcatctc aataattgat gatctttcta agtacgatgt

1021 tcaagtgaga gcagcagtga gctccatgtg cagagaggca gggctctgga gtgagtggag

1081 ccaacctatt tatgtgggaa atgatgaaca caagcccttg agagagtggt ttgtcattgt

1141 gattatggca accatctgct tcatcttgtt aattctctcg cttatctgta aaatatgtca

1201 tttatggatc aagttgtttc caccaattcc agcaccaaaa agtaatatca aagatctctt

1261 tgtaaccact aactatgaga aagctggaat ttaaattcaa gcatgtttta acttttggtt

1321 taaggtactt gggtgtacct ggcagtgttg taagctcttt acattaatta attaactctc

1381 taggtactgt tatcttcatt ttataaacaa ggcagctgaa gttgagagaa ataagtaacc

1441 tgtcctaggt cacacaatta ggaaatgaca gatctggcag tctatttcca ggcagtctat

1501 ttccacgagg tcatgagtgc gaaagaggga ctaggggaag aatgattaac tccagggagc

1561 tgacttttct agtgtgctta cctgttttgc atctctcaag gatgtgccat gaagctgtag

1621 ccaggtggaa ttgtaccaca gccctgacat gaacacctga tggcagctgc tgggttggag

1681 cctagacaaa aacatgaaga accatggctg ctgcctgagc ccatcgtgct gtaattatag

1741 aaaaccttct aagggaagaa tatgctgata tttttcagat aagtacccct tttataaaaa

1801 tcctccaagt tagccctcga ttttccatgt aaggaaacag aggctttgag ataatgtctg

1861 tctcctaagg gacaaagcca ggacttgatc ctgtcttaaa aatgcaaaat gtagtacttc

1921 ttccatcaaa ggtagacatg cactaaggga caggttttgg cttggtatca gaatacattt

1981 ttaaaagctg tgtaagaatt gaacgggctg tactaggggg tata

1 gatctttcta agtacgatgt tcaagtgaga gcagcagtga gctccatgtg cagagaggca

61 gggctctgga gtgagtggag ccaacctatt tatgtgggaa atgatgaaca caagcccttg

121 agagagtggt ttgtcattgt gattatggca accatctgct tcatcttgtt aattctctcg

181 cttatctgta aaatatgtca tttatggatc aagttgtttc caccaattcc agcaccaaaa

241 agtaatatca aagatctctt tgtaaccact aactatgagg tcctctgcat tttcatatac

301 atcttagatt cggctgacaa ttttctacaa aaaaagaaag ctgggtccag tgagacggaa

361 attgaagtca tctgttatat agagaagcct ggagttgaga ccctggagga ttctgtgttt

421 tgactgtcac tttggcatcc tctgatgaac tcacacatgc ctcagtgcct cagtgaaaag

481 aacagggatg ctggctcttg gctaagaggt gttcagaatt taggcaacac tcaatttacc

541 tgcgaagcaa tacacccaga cacaccagtc ttgtatctct taaaagtatg gatgcttcat

601 ccaaatcgcc tcacctacag cagggaagtt gactcatcca agcattttgc catgtttttt

661 ctccccatgc cgtacagggt agcacctcct cacctgccaa tctttgcaat ttgcttgact

721 cacctcagac ttttcattca caacagacag cttttaaggc taacgtccag ctgtatttac

781 ttctggctgt gcccgtttgg ctgtttaagc tgccaattgt agcactcagc taccatctga

841 ggaagaaagc attttgcatc agcctggagt gaaccatgaa cttggattca agactgtctt

901 ttctatagca agtgagagcc acaaattcct c

1 ccgctgcttc tcatcgcatg gccaccgcat ttctcaggcc aggcacattg agcattggtc

61 ctgtgcctga cgctatgcta gatgctgggg ttgcagccac gagcatagac acgacagaca

121 cggtcctcgc catcttctgt tgagtactgg tcggaacaag aggatcgtct gtagacaggc

181 tacagattgt tttagattga agtttcctgt catgttcact catctttaaa tcctcatagt

241 aaaaaggata tgatcatcgt ggcgcatgta ttactcatcc ttttgggggc cactgagata

301 ctgcaagctg acttacttcc tgatgaaaag atttcacttc tcccacctgt caatttcacc

361 attaaagtta ctggtttggc tcaagttctt ttacaatgga aaccaaatcc tgatcaagag

421 caaaggaatg ttaatctaga atatcaagtg aaaataaacg ctccaaaaga agatgactat

481 gaaaccagaa tcactgaaag caaatgtgta accatcctcc acaaaggctt ttcagcaagt

541 gtgcggacca tcctgcagaa cgaccactca ctactggcca gcagctgggc ttctgctgaa

601 cttcatgccc caccagggtc tcctggaacc tcaattgtga atttaacttg caccacaaac

661 actacagaag acaattattc acgtttaagg tcataccaag tttcccttca ctgcacctgg

721 cttgttggca cagatgcccc tgaggacacg cagtattttc tctactatag gtatggctct

781 tggactgaag aatgccaaga atacagcaaa gacacactgg ggagaaatat cgcatgctgg

841 tttcccagga cttttatcct cagcaaaggg cgtgactggc tttcggtgct tgttaacggc

901 tccagcaagc actctgctat caggcccttt gatcagctgt ttgcccttca cgccattgat

961 caaataaatc ctccactgaa tgtcacagca gagattgaag gaactcgtct ctctatccaa

1021 tgggagaaac cagtgtctgc ttttccaatc cattgctttg attatgaagt aaaaatacac

1081 aatacaagga atggatattt gcagatagaa aaattgatga ccaatgcatt catctcaata

1141 attgatgatc tttctaagta cgatgttcaa gtgagagcag cagtgagctc catgtgcaga

1201 gaggcagggc tctggagtga gtggagccaa cctatttatg tggggttctc aagataaagg

1261 agataacatc cagctttcct gccccacacc gtatctgaaa taaaaacaac agcagggata

1321 gcagatt

1 ccgctgcttc tcatcgcatg gccaccgcat ttctcaggcc aggcacattg agcattggtc

61 ctgtgcctga cgctatgcta gatgctgggg ttgcagccac gagcatagac acgacagaca

121 cggtcctcgc catcttctgt tgagtactgg tcggaacaag aggatcgtct gtagacaggc

181 tacagattgt tttagattga agtttcctgt catgttcact catctttaaa tcctcatagt

241 aaaaaggata tgatcatcgt ggcgcatgta ttactcatcc ttttgggggc cactgagata

301 ctgcaagctg acttacttcc tgatgaaaag atttcacttc tcccacctgt caatttcacc

361 attaaagtta ctggtttggc tcaagttctt ttacaatgga aaccaaatcc tgatcaagag

421 caaaggaatg ttaatctaga atatcaagtg aaaataaacg ctccaaaaga agatgactat EPI-109 723

481 gaaaccagaa tcactgaaag caaatgtgta accatcctcc acaaaggctt ttcagcaagt

541 gtgcggacca tcctgcagaa cgaccactca ctactggcca gcagctgggc ttctgctgaa

601 cttcatgccc caccagggtc tcctggaacc tcaattgtga atttaacttg caccacaaac

661 actacagaag acaattattc acgtttaagg tcataccaag tttcccttca ctgcacctgg

721 cttgttggca cagatgcccc tgaggacacg cagtattttc tctactatag gtatggctct

781 tggactgaag aatgccaaga atacagcaaa gacacactgg ggagaaatat cgcatgctgg

841 tttcccagga cttttatcct cagcaaaggg cgtgactggc tttcggtgct tgttaacggc

901 tccagcaagc actctgctat caggcccttt gatcagctgt ttgcccttca cgccattgat

961 caaataaatc ctccactgaa tgtcacagca gagattgaag gaactcgtct ctctatccaa

1021 tgggagaaac cagtgtctgc ttttccaatc cattgctttg attatgaagt aaaaatacac

1081 aatacaagga atggatattt gcagatagaa aaattgatga ccaatgcatt catctcaata

1141 attgatgatc tttctaagta cgatgttcaa gtgagagcag cagtgagctc catgtgcaga

1201 gaggcagggc tctggagtga gtggagccaa cctatttatg tgggtaagta gcttatgttt

1261 attttacatt ggcagccttc cttgtgatca aaaaaggtaa tcccagaaac gtacccgttc

1321 actcgtgggt cttaaaatgg tttcatatct ctattgtgac taattttctc tcggtctact

1381 gccttttcaa tcaggaatag atttgccatg aagccagtga agtttttaag tgtctaggct

1441 tctcattagt gccaactctc ctagacctgg tgcctgtttt ttttccaagt tttgtttcta

1501 cttctatcca ttttttaaat taaacttttt attttgaaat aattatcaca ctcacaagct

1561 gtgggaagaa ataatagaga tcctgtgtct ctttcatcca gttttcctca agggtaacat

1621 cttacaaaac tatagtacaa tagtggaata gaatatttgg tgtt

1 ccgctgcttc tcatcgcatg gccaccgcat ttctcaggcc aggcacattg agcattggtc

61 ctgtgcctga cgctatgcta gatgctgggg ttgcagccac gagcatagac acgacagaca

121 cggtcctcgc catcttctgt tgagtactgg tcggaacaag aggatcgtct gtagacaggc

181 tacagattgt tttagattga agtttcctgt catgttcact catctttaaa tcctcatagt

241 aaaaaggata tgatcatcgt ggcgcatgta ttactcatcc ttttgggggc cactgagata

301 ctgcaagctg acttacttcc tgatgaaaag atttcacttc tcccacctgt caatttcacc

361 attaaagtta ctggtttggc tcaagttctt ttacaatgga aaccaaatcc tgatcaagag

421 caaaggaatg ttaatctaga atatcaagtg aaaataaacg ctccaaaaga agatgactat

481 gaaaccagaa tcactgaaag caaatgtgta accatcctcc acaaaggctt ttcagcaagt

541 gtgcggacca tcctgcagaa cgaccactca ctactggcca gcagctgggc ttctgctgaa

601 cttcatgccc caccagggtc tcctggaacc tcaattgtga atttaacttg caccacaaac

661 actacagaag acaattattc acgtttaagg tcataccaag tttcccttca ctgcacctgg

721 cttgttggca cagatgcccc tgaggacacg cagtattttc tctactatag gtatggctct

781 tggactgaag aatgccaaga atacagcaaa gacacactgg ggagaaatat cgcatgctgg

841 tttcccagga cttttatcct cagcaaaggg cgtgactggc tttcggtgct tgttaacggc

901 tccagcaagc actctgctat caggcccttt gatcagctgt ttgcccttca cgccattgat

961 caaataaatc ctccactgaa tgtcacagca gagattgaag gaactcgtct ctctatccaa

1021 tgggagaaac cagtgtctgc ttttccaatc cattgctttg attatgaagt aaaaatacac

1081 aatacaagga atggatattt gcagatagaa aaattgatga ccaatgcatt catctcaata

1141 attgatgatc tttctaagta cgatgttcaa gtgagagcag cagtgagctc catgtgcaga

1201 gaggcagggc tctggagtga gtggagccaa cctatttatg tgggaaatga tgaacacaag

1261 cccttgagag agtggtttgt cattgtgatt atggcaacca tctgcttcat cttgttaatt

1321 ctctcgctta tctgtaaaat atgtcattta tggatcaagt tgtttccacc aattccagca

1381 ccaaaaagta atatcaaaga tctctttgta accactaact atgagaaagc tgggtccagt

1441 gagacggaaa ttgaagtcat ctgttatata gagaagcctg gagttgagac cctggaggat

1501 tctgtgtttt gactgtcact ttggcatcct ctgatgaact cacacatgcc tcagtgcctc

1561 agtgaaaaga acagggatgc tggctcttgg ctaagaggtg ttcagaattt aggcaacact

1621 caatttacct gcgaagcaat acacccagac acaccagtct tgtatctctt aaaagtatgg

1681 atgcttcatc caaatcgcct cacctacagc agggaagttg actcatccaa gcattttgcc

1741 atgttttttc tccccatgcc gtacagggta gcacctcctc acctgccaat ctttgcaatt

1801 tgcttgactc acctcagact ttcattcaca acagacagct tttaaggcta acgtccagct

1861 gtatttactt ctggctgtgc cgtttggctg tttaagctgc caattgtagc actcagctac

1921 catctgagga agaaagcatt ttgcatcagc ctggagtgaa ccatgaactt ggattcaaga

1981 ctgtcttttc tatagcaa

1 gtcttttgaa aggatctgcc gctgcttctc atcgcatggc caccgcattt ctcaggccag 61 gcacattgag cattggtcct gtgcctgacg ctatgctaga tgctggggtt gcagccacga 121 gcatagacac gacagacacg gtcctcgcca tcttctgttg agtactggtc ggaacaagag 181 gatcgtctgt agacaggata tgatcatcgt ggcgcatgta ttactcatcc ttttgggggc 241 cactgagata ctgcaagctg acttacttcc tgatgaaaag atttcacttc tcccacctgt 301 caatttcacc attaaagtta ctggtttggc tcaagttctt ttacaatgga aaccaaatcc 361 tgatcaagag caaaggaatg ttaatctaga atatcaagtg aaaataaacg ctccaaaaga 421 agatgactat gaaaccagaa tcactgaaag caaatgtgta accatcctcc acaaaggctt 481 ttcagcaagt gtgcggacca tcctgcagaa cgaccactca ctactggcca gcagctgggc 541 ttctgctgaa cttcatgccc caccagggtc tcctggaacc tcaattgtga atttaacttg 601 caccacaaac actacagaag acaattattc acgtttaagg tcataccaag tttcccttca 661 ctgcacctgg cttgttggca cagatgcccc tgaggacacg cagtattttc tctactatag 721 gtatggctct tggactgaag aatgccaaga atacagcaaa gacacactgg ggagaaatat 781 cgcatgctgg tttcccagga cttttatcct cagcaaaggg cgtgactggc ttgcggtgct EPI-109 724

841 tgttaacggc tccagcaagc actctgctat caggcccttt gatcagctgt ttgcccttca 901 cgccattgat caaataaatc ctccactgaa tgtcacagca gagattgaag gaactcgtct 961 ctctatccaa tgggagaaac cagtgtctgc ttttccaatc cattgctttg attatgaagt 1021 aaaaatacac aatacaagga atggatattt gcagatagaa aaattgatga ccaatgcatt 1081 catctcaata attgatgatc tttctaagta cgatgttcaa gtgagagcag cagtgagctc 1141 catgtgcaga gaggcagggc tctggagtga gtggagccaa cctatttatg tgggtaagta 1201 gcttatgttt attttacatt ggcagccttc cttgtgatca aaaaaggtaa tcccagaaac 1261 gtacccgttc actcgtgggt cttaaaatgg tttcatatct ctattgtgac taattttctc 1321 tcggtctact gccttttcaa tcaggaatag atttgccatg aagccagtga agtttttaag 1381 tgtctaggct tctcattagc gccac

1 cggtcctcgc catcttctgt tgagtactgg tcggaacaag aggatcgtct gtagacagga

61 tatgatcatc gtggcgcatg tattactcat ccttttgggg gccactgaga tactgcaagc

121 tgacttactt cctgatgaaa agatttcact tctcccacct gtcaatttca ccattaaagt

181 tactggtttg gctcaagttc ttttacaatg gaaaccaaat cctgatcaag agcaaaggaa

241 tgttaatcta gaatatcaag tgaaaataaa cgctccaaaa gaagatgact atgaaaccag

301 aatcactgaa agcaaatgtg taaccatcct ccacaaaggc ttttcagcaa gtgtgcggac

361 catcctgcag aacgaccact cactactggc cagcagctgg gcttctgctg aacttcatgc

421 cccaccaggg tctcctggaa cctcagttgt gaatttaact tgcaccacaa acactacaga

481 agacaattat tcacgtttaa ggtcatacca agtttccctt cactgcacct ggcttgttgg

541 cacagatgcc cctgaggaca cgcagtattt tctctactat aggtatggct cttggactga

601 agaatgccaa gaatacagca aagacacact ggggagaaat atcgcatgct ggtttcccag

661 gacttttatc ctcagcaaag ggcgtgactg gcttgcggtg cttgttaacg gctccagcaa

721 gcactctgct atcaggccct ttgatcagct gtttgccctt cacgccattg atcaaataaa

781 tcctccactg aatgtcacag cagagattga aggaactcgt ctctctatcc aatgggagaa

841 accagtgtct gcttttccaa tccattgctt tgattatgaa gtaaaaatac acaatacaag

901 gaatggatat ttgcagatag aaaaattgat gaccaatgca ttcatctcaa taattgatga

961 tctttctaag tacgatgttc aagtgagagc agcagtgagc tccatgtgca gagaggcagg

1021 gctctggagt gagtggagcc aacctattta tgtgggaaat gatgaacaca agcccttgag

1081 agagtggttt gtcattgtga ttatggcaac catctgcttc atcttgttaa ttctctcgct

1141 tatctgtaaa atatgtcatt tatggatcaa gttgtttcca ccaattccag caccaaaaag

1201 taatatcaaa gatctctttg taaccactaa ctatgagaaa gctgggtcca gtgagacgga

1261 aattgaagtc atctgttata tagagaagcc tggagttgag accctggagg attctgtgtt

1321 ttgactgtca ctttggcatc ctctgatgaa ctcacacatg cctcagtgcc tcagtgaaaa

1381 gaacagggat gctggctctt ggctaagagg tgttcagaat ttaggcaaca ctcaatttac

1441 ctgcgaagca atacacccag acacaccagt cttgtatctc ttaaaagtat ggatgcttca

1501 tccaaatcgc ctcacctaca gcagggaagt tgactcatcc aagcattttg ccatgttttt

1561 tctccccatg ccgtacaggg tagcacctcc tcacctgcca atctttgcaa tttgcttgac

1621 tcacctcaga cttttcattc acaacagaca gcttttaagg ctaacgtcca gctgtattta

1681 cttctggctg tgcccgtttg gctgtttaag ctgccaattg tagcactcag ctaccatctg

1741 aggaagaaag cattttgcat cagcctggag tgaatcatga acttggattc aagactgtct

1801 tttctatagc aagtgagagc cacaaattcc tcacccccct acattctaga atgatctttt

1861 tctaggtaga ttgtgtatgt gtgtgtatga gagagagaga gagagagaga gagagagaga

1921 gagaaattat ctcaagctcc agaggcctga tccaggatac atcatttgaa accaactaat

1981 ttaaaagcat aatagagcta atatat

(2) INFORMATION FOR SEQ ID NO:2556: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 5161 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2556:

1 gaattcagta acccaggcat tattttatcc tcaagtctta ggttggttgg agaaagataa

61 caaaaagaaa catgattgtg cagaaacaga caaacctttt tggaaagcat ttgaaaatgg

121 cattccccct ccacagtgtg ttcacagtgt gggcaaattc actgctctgt cgtactttct

181 gaaaatgaag aactgttaca ccaaggtgaa ttatttataa attatgtact tgcccagaag

241 cgaacagact tttactatca taagaaccct tccttggtgt gctctttatc tacagaatcc

301 aagacctttc aagaaaggtc ttggattctt ttcttcagga cactaggaca taaagccacc

361 tttttatgat ttgttgaaat ttctcactcc atcccttttg ctgatgatca tgggtcctca

421 gaggtcagac ttggtgtcct tggataaaga gcatgaagca acagtggctg aaccagagtt

481 ggaacccaga tgctctttcc actaagcata caactttcca ttagataaca cctccctccc

541 accccaacca agcagctcca gtgcaccact ttctggagca taaacatacc ttaactttac

601 aacttgagtg gccttgaata ctgttcctat ctggaatgtg ctgttctctt tcatcttcct

661 ctattgaagc cctcctattc ctcaatgcct tgctccaact gcctttggaa gattctgctc

721 ttatgcctcc actggaatta atgtcttagt accacttgtc tattctgcta tatagtcagt

781 ccttacattg ctttcttctt ctgatagacc aaactcttta aggacaagta cctagtctta

841 tctatttcta gatcccccac attactcaga aagttactcc ataaatgttt gtggaactga

901 tttctatgtg aagacatgtg ccccttcact ctgttaacta gcattagaaa aacaaatctt

961 ttgaaaagtt gtagtatgc^'c cctaagagca gtaacagttc ctagaaactc tctaaaatgc EPI-109 725

1021 ttagaaaaag atttatttta aattacctcc ccaataaaat gattggctgg cttatcttca 1081 ccatcatgat agcatctgta attaactgaa aaaaaataat tatgccatta aaagaaaatc 1141 atccatgatc ttgttctaac acctgccact ctagtactat atctgtcaca tggtctatga 1201 taaagttatc tagaaataaa aaagcataca attgataatt caccaaattg tggagcttca 1261 gtattttaaa tgtatattaa aattaaatta ttttaaagat caaagaaaac tttcgtcata 1321 ctccgtattt gataaggaac aaataggaag tgtgatgact caggtttgcc ctgaggggat 1381 gggccatcag ttgcaaatcg tggaatttcc tctgacataa tgaaaagatg agggtgcata 1441 agttctctag tagggtgatg atataaaaag ccaccggagc actccataag gcacaaactt 1501 tcagagacag cagagcacac aagcttctag gacaagagcc aggaagaaac caccggaagg 1561 aaccattctc actgtgtgta aacatgactt ccaagctggc cgtggctctc ttggcagcct 1621 tcctgatttc tgcagctctg tgtgaaggta agcacatctt tctgacctac agcgttttcc 1681 tatgtctaaa tgtgatcctt agatagcaaa gctattcttg atgctttggt aacaaacatc 1741 ctttttattc agaaacagaa tataatctta gcagtcaatt aatgttaaat tgaagattta 1801 gaaaaaacta tatataacac ttaggaaata taaaggtttg atcaatatag atattctgct 1861 tttataattt ataccaggta gcatgcatat atttaacgta aataagtaat ttatagtatg 1921 tcctattgag aaccacggtt acctatatta tgtattaata ttgagttgag caaggtaact 1981 cagacaattc cactccttgt agtatttcat tgacaagcct cagatttgtc attaattcct 2041 gtctggttta aagataccct gattatagac caggcatgta taacttattt atatatttct 2101 gttaattctt tctgaaggca atttctatgc tggagagtct tagcttgcct actataaata 2161 acactgtggt atcacagagg attatgcaat attgaccaga taaaaatacc atgaagatgt 2221 tgatattgta caaaaagaac tctaactctt atataggaag ttgttcaatg ttgtcagtta 2281 tgactgtttt ttaaaacaaa gaactaactg aggtcaaggg ctaggagata ttcaggaatg 2341 agttcactag aaacatgatg ccttccatag tctccaaata atcatattgg aattagaagg 2401 aagtagctgg cagagctgtg cctgttgata aaatcaatcc ttaatcactt tttcccccaa 2461 caggtgcagt tttgccaagg agtgctaaag aacttagatg tcagtgcata aagacatact 2521 ccaaaccttt ccaccccaaa tttatcaaag aactgagagt gattgagagt ggaccacact 2581 gcgccaacac agaaattatg taagtacttt aaaaaagatt agatattttg ttttagcaaa 2641 cttaaaatta aggaaggtgg aaatatttag gaaagttcca ggtgttagga ttacagtagt 2701 aaatgaaaca aaacaaaata aaaatatttg tctacatgac atttaaatat ggtagcttcc 2761 acaactacta taaatgttat tttggactta gactttatgc ctgacttaag gaatcatgat 2821 ttgaatgcaa aaactaaata ttaatctgaa ccatttcttt cttatttcag tgtaaagctt 2881 tctgatggaa gagagctctg tctggacccc aaggaaaact gggtgcagag ggttgtggag 2941 aagtttttga agaggtaagt tatatatttt ttaatttaaa tttttcattt atcctgagac 3001 atataatcca aagtcagcct ataaatttct ttctgttgct aaaaatcgtc attaggtatc 3061 tgcctttttg gttaaaaaaa aaggaatagc atcaatagtg agtttgttgt acttatgacc 3121 agaaagacca tacatagttt gcccaggaaa ttctgggttt aagcttgtgt cctatactct 3181 tagtaaagtt ctttgtcact cccagtagtg tcctatttta gatgataatt tctttgatct 3241 ccctatttat agttgagaat atagagcatt tctaacacat gaatgtcaaa gactatattg 3301 acttttcaag aaccctactt tccttcttat taaacatagc tcatctttat atttttaatt 3361 ttattttagg gctgagaatt cataaaaaaa ttcattctct gtggtatcca agaatcagtg 3421 aagatgccag tgaaacttca agcaaatcta cttcaacact tcatgtattg tgtgggtctg 3481 ttgtagggtt gccagatgca atacaagatt cctggttaaa tttgaatttc agtaaacaat 3541 gaatagtttt tcattgtacc atgaaatatc cagaacatac ttatatgtaa agtattattt 3601 atttgaatct acaaaaaaca acaaataatt tttaaatata aggattttcc tagatattgc 3661 acgggagaat atacaaatag caaaattggg ccaagggcca agagaatatc cgaactttaa 3721 tttcaggaat tgaatgggtt tgctagaatg tgatatttga agcatcacat aaaaatgatg 3781 ggacaataaa ttttgccata aagtcaaatt tagctggaaa tcctggattt ttttctgtta 3841 aatctggcaa ccctagtctg ctagccagga tccacaagtc cttgttccac tgtgccttgg 3901 tttctccttt atttctaagt ggaaaaagta ttagccacca tcttacctca cagtgatgtt 3961 gtgaggacat gtggaagcac tttaagtttt ttcatcataa cataaattat tttcaagtgt 4021 aacttattaa cctatttatt atttatgtat ttatttaagc atcaaatatt tgtgcaagaa 4081 tttggaaaaa tagaagatga atcattgatt gaatagttat aaagatgtta tagtaaattt 4141 attttatttt agatattaaa tgatgtttta ttagataaat ttcaatcagg gtttttagat 4201 taaacaaaca aacaattggg tacccagtta aattttcatt tcagatatac aacaaataat 4261 tttttagtat aagtacatta ttgtttatct gaaattttaa ttgaactaac aatcctagtt 4321 tgatactccc agtcttgtca ttgccagctg tgttggtagt gctgtgttga attacggaat 4381 aatgagttag aactattaaa acagccaaaa ctccacagtc aatattagta atttcttgct 4441 ggttgaaact tgtttattat gtacaaatag attcttataa tattatttaa atgactgcat 4501 ttttaaatac aaggctttat atttttaact ttagtgtttt tatgtgctct ccaaattttt 4561 tttactgttt ctgattgtat ggaaatataa aagtaaatat gaaacattta aaatataatt 4621 tgttgtcaaa gtaatcaagt gtttgtcttt tttttagttt tagcttattg ggattctctt 4681 tgtttatatt taaaattata ctttgattta gaaaacataa atgcttcccc ttagcatttt 4741 gttatggaaa attacaaact tttattttta gaaaacagaa ctcctttcca gaaataggtt 4801 acaaacagta gtgtcctcca cagaatgttg gaaatgtttt caactcccca ctgtatacta 4861 tcttgctaat aagtctgtct tcagatttcg attaaccggt ttgtatgtct gtgcacttta 4921 gcatagctgg acattaaaga ggaaagagag tacatattat aagttgctta tcagtaactg 4981 aggagtaaaa ctgataaatg tgaggcaaag aagtttaaaa tatggttaaa gcctaagcat 5041 atttgcaaac aaatcaaaca atactctgag aagtaaaaac ataattattt aattaacaaa EPI-109 726

5101 tttcagtgga taaattttat aacaaattag acacagttga aaataaaatt agaaaactag 5161 aaaatagaac aaaagaaact tctggaattc a

(2) INFORMATION FOR SEQ ID NO: 2557: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1981 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2557:

1 tattcatcaa gtgccctcta gctgttaagt cactctgatc tctgactgca gctcctactg

61 ttggacacac ctggccggtg cttcagttag atcaaaccat tgctgaaact gaagaggaca

121 tgtcaaatat tacagatcca cagatgtggg attttgatga tctaaatttc actggcatgc

181 cacctgcaga tgaagattac agcccctgta tgctagaaac tgagacactc aacaagtatg

241 ttgtgatcat cgcctatgcc ctagtgttcc tgctgagcct gctgggaaac tccctggtga

301 tgctggtcat cttatacagc agggtcggcc gctccgtcac tgatgtctac ctgctgaacc

361 tggccttggc cgacctactc tttgccctga ccttgcccat ctgggccgcc tccaaggtga

421 atggctggat ttttggcaca ttcctgtgca aggtggtctc actcctgaag gaagtcaact

481 tctacagtgg catcctgctg ttggcctgca tcagtgtgga ccgttacctg gccattgtcc

541 atgccacacg cacactgacc cagaagcgtc acttggtcaa gtttgtttgt cttggctgct

601 ggggactgtc tatgaatctg tccctgccct tcttcctttt ccgccaggct taccatccaa

661 acaattccag tccagtttgc tatgaggtcc tgggaaatga cacagcaaaa tggcggatgg

721 tgttgcggat cctgcctcac acctttggct tcatcgtgcc gctgtttgtc atgctgttct

781 gctatggatt caccctgcgt acactgttta aggcccacat ggggcagaag caccgagcca

841 tgagggtcat ctttgctgtc gtcctcatct tcctgctttg ctggctgccc tacaacctgg

901 tcctgctggc agacaccctc atgaggaccc aggtgatcca ggagagctgt gagcgccgca

961 acaacatcgg ccgggccctg gatgccactg agattctggg atttctccat agctgcctca

1021 accccatcat ctacgccttc atcggccaaa attttcgcca tggattcctc aagatcctgg

1081 ctatgcatgg cctggtcagc aaggagttct tggcacgtca tcgtgttacc tcctacactt

1141 cttcgtctgt caatgtctct tccaacctct gaaaaccatc gatgaaggaa tatctcttct

1201 cagaaggaaa gaataaccaa caccctgagg ttgtgtgtgg aaggtgatct ggctctggac

1261 aggcactatc tgggttttgg ggggacgcta taggatgtgg ggaagttagg aactggtgtc

1321 ttcaggggcc acaccaacct tctgaggagc tgttgaggta cctccaagga ccggcctttg

1381 cacctccatg gaaacgaagc accatcattc ccgttgaacg tcacatcttt aacccactaa

1441 ctggctaatt agcatggcca catctgagcc ccgaatctga cattagatga gagaacaggg

1501 ctgaagctgt gtcctcatga gggctggatg ctctcgttga ccctcacagg agcatctcct

1561 caactctgag tgttaagcgt tgagccacca agctggtggc tctgtgtgct ctgatccgag

1621 ctcagggggg tggttttccc atctcaggtg tgttgcagtg tctgctggag acattgaggc

1681 aggcactgcc aaaacatcaa cctgccagct ggccttgtga ggagctggaa acacatgttc

1741 cccttggggg tggtggatga acaaagagaa agagggtttg gaagccagat ctatgccaca

1801 agaaccccct ttacccccat gaccaacatc gcagacacat gtgctggcca cctgctgagc

1861 cccaagtgga acgagacaag cagcccttag cccttcccct ctgcagcttc caggctggcg

1921 tgcagcatca gcatccctag aaagccatgt gcagccacca gtccattggg caggcagatg

1981 ttcctaataa agcttctgtt ccgtgct

(2) INFORMATION FOR SEQ ID NO: 2558: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1741 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2558:

1 cctacaggtg aaaagcccag cgacccagtc aggatttaag tttacctcaa aaatggaaga

61 ttttaacatg gagagtgaca gctttgaaga tttctggaaa ggtgaagatc ttagtaatta

121 cagttacagc tctaccctgc ccccttttct actagatgcc gccccatgtg aaccagaatc

181 cctggaaatc aacaagtatt ttgtggtcat tatctatgcc ctggtattcc tgctgagcct

241 gctgggaaac tccctcgtga tgctggtcat cttatacagc agggtcggcc gctccgtcac

301 tgatgtctac ctgctgaacc tagccttggc cgacctactc tttgccctga ccttgcccat

361 ctgggccgcc tccaaggtga atggctggat ttttggcaca ttcctgtgca aggtggtctc

421 actcctgaag gaagtcaact tctatagtgg catcctgcta ctggcctgca tcagtgtgga

481 ccgttacctg gccattgtcc atgccacacg cacactgacc cagaagcgct acttggtcaa

541 attcatatgt ctcagcatct ggggtctgtc cttgctcctg gccctgcctg tcttactttt

601 ccgaaggacc gtctactcat ccaatgttag cccagcctgc tatgaggaca tgggcaacaa

661 tacagcaaac tggcggatgc tgttacggat cctgccccag tcctttggct tcatcgtgcc

721 actgctgatc atgctgttct gctacggatt caccctgcgt acgctgttta aggcccacat

781 ggggcagaag caccgggcca tgcgggtcat ctttgctgtc gtcctcatct tcctgctttg

841 ctggctgccc tacaacctgg tcctgctggc agacaccctc atgaggaccc aggtgatcca

901 ggagacctgt gagcgccgca atcacatcga ccgggctctg gatgccaccg agattctggg

961 catccttcac agctgcctca accccctcat ctacgccttc attggccaga agtttcgcca EPI-109 727

1021 tggactcctc aagattctag ctatacatgg cttgatcagc aaggactccc tgcccaaaga

1081 cagcaggcct tcctttσttg gctcttcttc agggcacact tccactactc tctaagacct

1141 cctgcctaag tgcagccccg tggggttcct cccttctctt cacagtcaca ttccaagcct

1201 catgtccact ggttcttctt ggtctcagtg tcaatgcagc ccccattgtg gtcacaggaa

1261 gcagaggagg ccacgttctt actagtttcc cttgcatggt ttagaaagct tgccctggtg

1321 cctcacccct tgccataatt actatgtcat ttgctggagc tctgcccatc ctgcccctga

1381 gcccatggca ctctatgttc taagaagtga aaatctacac tccagtgaga cagctctgca

1441 tactcattag gatggctagt atcaaaagaa agaaaatcag gctggccaac gggatgaaac

1501 cctgtctcta ctaaaaatac aaaaaaaaaa aaaaaaatta gccgggcgtg gtggtgagtg

1561 cctgtaatca cagctacttg ggaggctgag atgggagaat cacttgaacc cgggaggcag

1621 aggttgcagt gagccgagat tgtgcccctg cactccagcc tgagcgacag tgagactctg

1681 tctcagtcca tgaagatgta gaggagaaac tggaactctc gagcgttgct gggggggatt

1741 gtaaaatggt

(2) INFORMATION FOR SEQ ID NO:2559: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1801 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2559:

1 ggatccaagt aggattgagt gtcctgtagt tattatccac agggaacatt ctacaaagtt

61 ttgggagact gtaatgtcat gggaaatgca agaatatgtg tccagcatgg aagggaatca

121 gtatggaagt cttttgataa attgtggcat ttatcactaa cattgcctca aaactttaga

181 ctacctgcca tatacaaatt agaggtgaaa attacttcca tgtaatatac aagccaacac

241 aaagaatcct atcccagttt cttggatgga taggcaagaa tctgggtaag gtttattgtg

301 caataatcct cttctctctt ctataggcca ggatttaagt ttacctcaaa aatggaaaat

361 tttggctggg aaaattacat gtgggaagac atcttcagtg gagattttag taattacagt

421 ttcagctatg accctacccc ttttctacta gattctgccc catgttggcc agaatcccta

481 gaaatcaatt atgttttgat catcatctat gccctgatgt ttctactgaa cgtgatgtga

541 aactccctgc cgatgctggt catcttattc agctgagtca gccactgtca ccgatgtcta

601 cctgctgacc ctggccttgg ccgacctgtt cttttccctg acattgccca tcttggctgc

661 ctccaagatg aatggctgga tttttggcac aatctgtgcc aggtggtcta gctcctgaag

721 gaagtcaact tctacggtgg tattctacta ctggcctgcc gcagcatgga ctgttacctg

781 gccattgtcc atgccacacg cacactgacc cagcagcgcc acttggtcaa gttcatatgt

841 ctgggtttgt ggaacctgtt cctgttactg tccctacgca tcttgctttt ccgaaggacc

901 ttctacccat ccaatgttag cccagtctgc tatgaggaca tgggcaacaa tacagcaaac

961 tggtggatgc tgttacggat cctgccccag tcctttggct tcatcgtgcc gctgcgatca

1021 tgctgttctg ctacagattc accctgcata cgctgtttaa ggcccatatg gggcagaagc

1081 actggaccat gtgggtcatc tttgctgttg tcctcatttt cctgctctgc tggctgccct

1141 acaacctggt cctgctggca gacaccctca tgggaaccca gatgaccaat gagacctgtg

1201 agcgccgcaa cgacatcaac caggccctgg atgccactga gattctgggc atccttcaca

1261 gctacctcaa tcccctcatc tacgccttca ttggccagaa gttttgccat ggacttctca

1321 agattatagc catacacggc ttgatcagca aggactccct gcccaaagac agcaggcctt

1381 cctttgttgg ctcttcttca gggcacactt ccactactct ctaagacctc ttgcctaagt

1441 gcagtcccgt ggggttcctc ccttctcttc acagtcacat tccaagcctc atgtccacta

1501 gctcttcttg gtctcagtgt cagtgcagcc cccactgtgg tcgcaggaag cagaggaggc

1561 cacgttctta ctagtttccc ttgcatgatt tagaaagcct gccctggtac ctcacccctt

1621 gccataatta ctacatcact tgctggagct ctgtccctcc tgcccttgag ctcatggcac

1681 tctatgttct aagaagtgaa aatctacact ccagtgagac agctctgcat actcattagg

1741 atggttaatg tcagaagaaa gaaaatcata aaatagaagg tgtccacaaa ggtgcagatg

1801 ataagtg

(2) INFORMATION FOR SEQ ID NO:2560: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1501 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xι)SEQUENCE DESCRIPTION: SEQ ID NO:2560:

1 gtcaggattt aagtttacct caaaaatgga agattttaac atggagagtg acagctttga

61 agatttctgg aaaggtgaag atcttagtaa ttacagttac agctctaccc tgcccccttt

121 tctactagat gccgccccat gtgaaccaga atccctggaa atcaacaagt attttgtggt

181 cattatctat gccctggtat tcctgctgag cctgctggga aactccctcg tgatgctggt

241 catcttatac agcagggtcg gccgctccgt cactgatgtc tacctgctga acctagcctt

301 ggccgaccta ctctttgccc tgaccttgcc catctgggcc gcctccaagg tgaatggctg

361 gatttttggc acattcctgt gcaaggtggt ctcactcctg aaggaagtca acttctatag

421 tggcatcctg ctactggcct gcatcagtgt ggaccgttac ctggccattg tccatgccac

481 acgcacactg acccagaagc gctacttggt caaattcata tgtctcagca tctggggtct EPI-109 728

541 gtccttgctc ctggccctgc ctgtcttact tttccgaagg accgtctact catccaatgt

601 tagcccagcc tgctatgagg acatgggcaa caatacagca aactggcgga tgctgttacg

661 gatcctgccc cagtcctttg gcttcatcgt gccactgctg atcatgctgt tctgctacgg

721 attcaccctg cgtacgctgt ttaaggccca catggggcag aagcaccggg ccatgcgggt

781 catctttgct gtcgtcctca tcttcctgct ttgctggctg ccctacaacc tggtcctgct

841 ggcagacacc ctcatgagga cccaggtgat ccaggagacc tgtgagcgcc gcaatcacat

901 cgaccgggct ctggatgcca ccgagattct gggcatcctt cacagctgcc tcaaccccct

961 catctacgcc ttcattggcc agaagtttcg ccatggactc ctcaagattc tagctataca

1021 tggcttgatc agcaaggact ccctgcccaa agacagcagg ccttcctttg ttggctcttc

1081 ttcagggcac acttccacta ctctctaaga cctcctgcct aagtgcagcc cgtggggttc

1141 ctcccttctc ttcacagtca cattccaagc ctcatgtcca ctggttcttc ttggtctcag

1201 tgtcaatgca gcccccattg tggtcacagg aagcagagga ggccacgttc ttactagttt

1261 cccttgcatg gtttagaaag cttgccctgg tgcctcaccc cttgccataa ttactatgtc

1321 atttgctgga gctctgccca tcctgcccct gagcccatgg cactctatgt tctaagaagt

1381 gaaaatctac actccagtga gacagctctg catactcatt aggatggcta gtatcaaaag

1441 aaagaaaatc aggctggcca acgggatgaa accctgtctc tactaaaaat acaaaaaaaa

1501 aaaaaaaaaa

(2) INFORMATION FOR SEQ ID NO:2561: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2221 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2561:

1 gggagaaaca tagggaatag aaaataagta agaaggggac acctgggaac aggtttgcct

61 tcttgcattt tgcttaatgc tggcccttcc ctgaatgtct aagaccaacc tggtccccac

121 atccaaatgc acagacacag ctgaggatgg agaaggctaa agagggacag aggtagagac

181 ataggctgag aggaggcagt tgtaggttga gctagggcta aggtgttttc cccatattcc

241 atcttacccc acactcaggc caggccttag agttgtggaa ggtggagaac actgggaagc

301 caacctccga agaagaccag gttggagtca aaggaggaag gagagctctc attgccaaac

361 caacagggaa gccaaggata tcccagtaac tgctctcaca tcattgatga gaatgccttg

421 aatccgagct actaaatcac atttccttcc ttctaacctt ccagttagat caaaccattg

481 ctgaaactga agaggacatg tcaaatatta cagatccaca gatgtgggat tttgatgatc

541 taaatttcac tggcatgcca cctgcagatg aagattacag cccctgtatg ctagaaactg

601 agacactcaa caagtatgtt gtgatcatcg cctatgccct agtgttcctg ctgagcctgc

661 tgggaaactc cctggtgatg ctggtcatct tatacagcag ggtcggccgc tccgtcactg

721 atgtctacct gctgaacctg gccttggccg acctactctt tgccctgacc ttgcccatct

781 gggccgcctc caaggtgaat ggctggattt ttggcacatt cctgtgcaag gtggtctcac

841 tcctgaagga agtcaacttc tacagtggca tcctgctgtt ggcctgcatc agtgtggacc

901 gttacctggc cattgtccat gccacacgca cactgaccca gaagcgtcac ttggtcaagt

961 ttgtttgtct tggctgctgg ggactgtcta tgaatctgtc cctgcccttc ttccttttcc

1021 gccaggctta ccatccaaac aattccagtc cagtttgcta tgaggtcctg ggaaatgaca

1081 cagcaaaatg gcggatggtg ttgcggatcc tgcctcacac ctttggcttc atcgtgccgc

1141 tgtttgtcat gctgttctgc tatggattca ccctgcgtac actgtttaag gcccacatgg

1201 ggcagaagca ccgagccatg agggtcatct ttgctgtcgt cctcatcttc ctgctttgct

1261 ggctgcccta caacctggtc ctgctggcag acaccctcat gaggacccag gtgatccagg

1321 agagctgtga gcgccgcaac aacatcggcc gggccctgga tgccactgag attctgggat

1381 ttctccatag ctgcctcaac cccatcatct acgccttcat cggccaaaat tttcgccatg

1441 gattcctcaa gatcctggct atgcatggcc tggtcagcaa ggagttcttg gcacgtcatc

1501 gtgttacctc ctacacttct tcgtctgtca atgtctcttc caacctctga aaaccatcga

1561 tgaaggaata tctcttctca gaaggaaaga ataaccaaca ccctgaggtt gtgtgtggaa

1621 ggtgatctgg ctctggacag gcactatctg ggttttgggg ggacgctata ggatgtgggg

1681 aagttaggaa ctggtgtctt caggggccac accaaccttc tgaggagctg ttgaggtacc

1741 tccaaggacc ggcctttgca cctccatgga aacgaagcac catcattccc gttgaacgtc

1801 acatctttaa cccactaact ggctaattag catggccaca tctgagcccc gaatctgaca

1861 ttagatgaga gaacagggct gaagctgtgt cctcatgagg gctggatgct ctcgttgacc

1921 ctcacaggag catctcctca actctgagtg ttaagcgttg agccaccaag ctggtggctc

1981 tgtgtgctct gatccgagct caggggggtg gttttcccat ctcaggtgtg ttgcagtgtc

2041 tgctggagac attgaggcag gcactgccaa aacatcaacc tgccagctgg ccttgtgagg

2101 agctggaaac acatgttccc cttgggggtg gtggatgaac aaagagaaag agggtttgga

2161 agccagatct atgccacaag aacccccttt acccccatga ccaacatcgc agacacatgt

2221 gctggccacc tgctgagccc caagt

(2) INFORMATION FOR SEQ ID NO:2562: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 9245 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single EPI-109 729

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2562:

1 tattcatcaa gtgccctcta gctgttaagt cactctgatc tctgactgca gctcctactg

61 ttggacacac ctggccggtg cttcagttag atcaaaccat tgctgaaact gaagaggaca

121 tgtcaaatat tacagatcca cagatgtggg attttgatga tctaaatttc actggcatgc

181 cacctgcaga tgaagattac agcccctgta tgctagaaac tgagacactc aacaagtatg

241 ttgtgatcat cgcctatgcc ctagtgttcc tgctgagcct gctgggaaac tccctggtga

301 tgctggtcat cttatacagc agggtcggcc gctccgtcac tgatgtctac ctgctgaacc

361 tggccttggc cgacctactc tttgccctga ccttgcccat ctgggccgcc tccaaggtga

421 atggctggat ttttggcaca ttcctgtgca aggtggtctc actcctgaag gaagtcaact

481 tctacagtgg catcctgctg ttggcctgca tcagtgtgga ccgttacctg gccattgtcc

541 atgccacacg cacactgacc cagaagcgtc acttggtcaa gtttgtttgt cttggctgct

601 ggggactgtc tatgaatctg tccctgccct tcttcctttt ccgccaggct taccatccaa

661 acaattccag tccagtttgc tatgaggtcc tgggaaatga cacagcaaaa tggcggatgg

721 tgttgcggat cctgcctcac acctttggct tcatcgtgcc gctgtttgtc atgctgttct

781 gctatggatt caccctgcgt acactgttta aggcccacat ggggcagaag caccgagcca

841 tgagggtcat ctttgctgtc gtcctcatct tcctgctttg ctggctgccc tacaacctgg

901 tcctgctggc agacaccctc atgaggaccc aggtgatcca ggagagctgt gagcgccgca

961 acaacatcgg ccgggccctg gatgccactg agattctggg atttctccat agctgcctca

1021 accccatcat ctacgccttc atcggccaaa attttcgcca tggattcctc aagatcctgg

1081 ctatgcatgg cctggtcagc aaggagttct tggcacgtca tcgtgttacc tcctacactt

1141 cttcgtctgt caatgtctct tccaacctct gaaaaccatc gatgaaggaa tatctcttct

1201 cagaaggaaa gaataaccaa caccctgagg ttgtgtgtgg aaggtgatct ggctctggac

1261 aggcactatc tgggttttgg ggggacgcta taggatgtgg ggaagttagg aactggtgtc

1321 ttcaggggcc acaccaacct tctgaggagc tgttgaggta cctccaagga ccggcctttg

1381 cacctccatg gaaacgaagc accatcattc ccgttgaacg tcacatcttt aacccactaa

1441 ctggctaatt agcatggcca catctgagcc ccgaatctga cattagatga gagaacaggg

1501 ctgaagctgt gtcctcatga gggctggatg ctctcgttga ccctcacagg agcatctcct

1561 caactctgag tgttaagcgt tgagccacca agctggtggc tctgtgtgct ctgatccgag

1621 ctcagggggg tggttttccc atctcaggtg tgttgcagtg tctgctggag acattgaggc

1681 aggcactgcc aaaacatcaa cctgccagct ggccttgtga ggagctggaa acacatgttc

1741 cccttggggg tggtggatga acaaagagaa agagggtttg gaagccagat ctatgccaca

1801 agaaccccct ttacccccat gaccaacatc gcagacacat gtgctggcca cctgctgagc

1861 cccaagtgga acgagacaag cagcccttag cccttcccct ctgcagcttc caggctggcg

1921 tgcagcatca gcatccctag aaagccatgt gcagccacca gtccattggg caggcagatg

1981 ttcctaataa agcttctgtt ccgtgct

1 cctacaggtg aaaagcccag cgacccagtc aggatttaag tttacctcaa aaatggaaga

61 ttttaacatg gagagtgaca gctttgaaga tttctggaaa ggtgaagatc ttagtaatta

121 cagttacagc tctaccctgc ccccttttct actagatgcc gccccatgtg aaccagaatc

181 cctggaaatc aacaagtatt ttgtggtcat tatctatgcc ctggtattcc tgctgagcct

241 gctgggaaac tccctcgtga tgctggtcat cttatacagc agggtcggcc gctccgtcac

301 tgatgtctac ctgctgaacc tagccttggc cgacctactc tttgccctga ccttgcccat

361 ctgggccgcc tccaaggtga atggctggat ttttggcaca ttcctgtgca aggtggtctc

421 actcctgaag gaagtcaact tctatagtgg catcctgcta ctggcctgca tcagtgtgga

481 ccgttacctg gccattgtcc atgccacacg cacactgacc cagaagcgct acttggtcaa

541 attcatatgt ctcagcatct ggggtctgtc cttgctcctg gccctgcctg tcttactttt

601 ccgaaggacc gtctactcat ccaatgttag cccagcctgc tatgaggaca tgggcaacaa

661 tacagcaaac tggcggatgc tgttacggat cctgccccag tcctttggct tcatcgtgcc

721 actgctgatc atgctgttct gctacggatt caccctgcgt acgctgttta aggcccacat

781 ggggcagaag caccgggcca tgcgggtcat ctttgctgtc gtcctcatct tcctgctttg

841 ctggctgccc tacaacctgg tcctgctggc agacaccctc atgaggaccc aggtgatcca

901 ggagacctgt gagcgccgca atcacatcga ccgggctctg gatgccaccg agattctggg

961 catccttcac agctgcctca accccctcat ctacgccttc attggccaga agtttcgcca

1021 tggactcctc aagattctag ctatacatgg cttgatcagc aaggactccc tgcccaaaga

1081 cagcaggcct tcctttgttg gctcttcttc agggcacact tccactactc tctaagacct

1141 cctgcctaag tgcagccccg tggggttcct cccttctctt cacagtcaca ttccaagcct

1201 catgtccact ggttcttctt ggtctcagtg tcaatgcagc ccccattgtg gtcacaggaa

1261 gcagaggagg ccacgttctt actagtttcc cttgcatggt ttagaaagct tgccctggtg

1321 cctcacccct tgccataatt actatgtcat ttgctggagc tctgcccatc ctgcccctga

1381 gcccatggca ctctatgttc taagaagtga aaatctacac tccagtgaga cagctctgca

1441 tactcattag gatggctagt atcaaaagaa agaaaatcag gctggccaac gggatgaaac

1501 cctgtctcta ctaaaaatac aaaaaaaaaa aaaaaaatta gccgggcgtg gtggtgagtg

1561 cctgtaatca cagctacttg ggaggctgag atgggagaat cacttgaacc cgggaggcag

1621 aggttgcagt gagccgagat tgtgcccctg cactccagcc tgagcgacag tgagactctg

1681 tctcagtcca tgaagatgta gaggagaaac tggaactctc gagcgttgct gggggggatt

1741 gtaaaatggt

1 ggatccaagt aggattgagt gtcctgtagt tattatccac agggaacatt ctacaaagtt 61 ttgggagact gtaatgtcat gggaaatgca agaatatgtg tccagcatgg aagggaatca EPI-109 730

121 gtatggaagt cttttgataa attgtggcat ttatcactaa cattgcctca aaactttaga

181 ctacctgcca tatacaaatt agaggtgaaa attacttcca tgtaatatac aagccaacac

241 aaagaatcct atcccagttt cttggatgga taggcaagaa tctgggtaag gtttattgtg

301 caataatcct cttctctctt ctataggcca ggatttaagt ttacctcaaa aatggaaaat

361 tttggctggg aaaattacat gtgggaagac atcttcagtg gagattttag taattacagt

421 ttcagctatg accctacccc ttttctacta gattctgccc catgttggcc agaatcccta

481 gaaatcaatt atgttttgat catcatctat gccctgatgt ttctactgaa cgtgatgtga

541 aactccctgc cgatgctggt catcttattc agctgagtca gccactgtca ccgatgtcta

601 cctgctgacc ctggccttgg ccgacctgtt cttttccctg acattgccca tcttggctgc

661 ctccaagatg aatggctgga tttttggcac aatctgtgcc aggtggtcta gctcctgaag

721 gaagtcaact tctacggtgg tattctacta ctggcctgcc gcagcatgga ctgttacctg

781 gccattgtcc atgccacacg cacactgacc cagcagcgcc acttggtcaa gttcatatgt

841 ctgggtttgt ggaacctgtt cctgttactg tccctacgca tcttgctttt ccgaaggacc

901 ttctacccat ccaatgttag cccagtctgc tatgaggaca tgggcaacaa tacagcaaac

961 tggtggatgc tgttacggat cctgccccag tcctttggct tcatcgtgcc gctgcgatca

1021 tgctgttctg ctacagattc accctgcata cgctgtttaa ggcccatatg gggcagaagc

1081 actggaccat gtgggtcatc tttgctgttg tcctcatttt cctgctctgc tggctgccct

1141 acaacctggt cctgctggca gacaccctca tgggaaccca gatgaccaat gagacctgtg

1201 agcgccgcaa cgacatcaac caggccctgg atgccactga gattctgggc atccttcaca

1261 gctacctcaa tcccctcatc tacgccttca ttggccagaa gttttgccat ggacttctca

1321 agattatagc catacacggc ttgatcagca aggactccct gcccaaagac agcaggcctt

1381 cctttgttgg ctcttcttca gggcacactt ccactactct ctaagacctc ttgcctaagt

1441 gcagtcccgt ggggttcctc ccttctcttc acagtcacat tccaagcctc atgtccacta

1501 gctcttcttg gtctcagtgt cagtgcagcc cccactgtgg tcgcaggaag cagaggaggc

1561 cacgttctta ctagtttccc ttgcatgatt tagaaagcct gccctggtac ctcacccctt

1621 gccataatta ctacatcact tgctggagct ctgtccctcc tgcccttgag ctcatggcac

1681 tctatgttct aagaagtgaa aatctacact ccagtgagac agctctgcat actcattagg

1741 atggttaatg tcagaagaaa gaaaatcata aaatagaagg tgtccacaaa ggtgcagatg

1801 ataagtg

1 gtcaggattt aagtttacct caaaaatgga agattttaac atggagagtg acagctttga

61 agatttctgg aaaggtgaag atcttagtaa ttacagttac agctctaccc tgcccccttt

121 tctactagat gccgccccat gtgaaccaga atccctggaa atcaacaagt attttgtggt

181 cattatctat gccctggtat tcctgctgag cctgctggga aactccctcg tgatgctggt

241 catcttatac agcagggtcg gccgctccgt cactgatgtc tacctgctga acctagcctt

301 ggccgaccta ctctttgccc tgaccttgcc catctgggcc gcctccaagg tgaatggctg

361 gatttttggc acattcctgt gcaaggtggt ctcactcctg aaggaagtca acttctatag

421 tggcatcctg ctactggcct gcatcagtgt ggaccgttac ctggccattg tccatgccac

481 acgcacactg acccagaagc gctacttggt caaattcata tgtctcagca tctggggtct

541 gtccttgctc ctggccctgc ctgtcttact tttccgaagg accgtctact catccaatgt

601 tagcccagcc tgctatgagg acatgggcaa caatacagca aactggcgga tgctgttacg

661 gatcctgccc cagtcctttg gcttcatcgt gccactgctg atcatgctgt tctgctacgg

721 attcaccctg cgtacgctgt ttaaggccca catggggcag aagcaccggg ccatgcgggt

781 catctttgct gtcgtcctca tcttcctgct ttgctggctg ccctacaacc tggtcctgct

841 ggcagacacc ctcatgagga cccaggtgat ccaggagacc tgtgagcgcc gcaatcacat

901 cgaccgggct ctggatgcca ccgagattct gggcatcctt cacagctgcc tcaaccccct

961 catctacgcc ttcattggcc agaagtttcg ccatggactc ctcaagattc tagctataca

1021 tggcttgatc agcaaggact ccctgcccaa agacagcagg ccttcctttg ttggctcttc

1081 ttcagggcac acttccacta ctctctaaga cctcctgcct aagtgcagcc cgtggggttc

1141 ctcccttctc ttcacagtca cattccaagc ctcatgtcca ctggttcttc ttggtctcag

1201 tgtcaatgca gcccccattg tggtcacagg aagcagagga ggccacgttc ttactagttt

1261 cccttgcatg gtttagaaag cttgccctgg tgcctcaccc cttgccataa ttactatgtc

1321 atttgctgga gctctgccca tcctgcccct gagcccatgg cactctatgt tctaagaagt

1381 gaaaatctac actccagtga gacagctctg catactcatt aggatggcta gtatcaaaag

1441 aaagaaaatc aggctggcca acgggatgaa accctgtctc tactaaaaat acaaaaaaaa

1501 aaaaaaaaaa

1 gggagaaaca tagggaatag aaaataagta agaaggggac acctgggaac aggtttgcct 61 tcttgcattt tgcttaatgc tggcccttcc ctgaatgtct aagaccaacc tggtccccac 121 atccaaatgc acagacacag ctgaggatgg agaaggctaa agagggacag aggtagagac 181 ataggctgag aggaggcagt tgtaggttga gctagggcta aggtgttttc cccatattcc 241 atcttacccc acactcaggc caggccttag agttgtggaa ggtggagaac actgggaagc 301 caacctccga agaagaccag gttggagtca aaggaggaag gagagctctc attgccaaac 361 caacagggaa gccaaggata tcccagtaac tgctctcaca tcattgatga gaatgccttg 421 aatccgagct actaaatcac atttccttcc ttctaacctt ccagttagat caaaccattg 481 ctgaaactga agaggacatg tcaaatatta cagatccaca gatgtgggat tttgatgatc 541 taaatttcac tggcatgcca cctgcagatg aagattacag cccctgtatg ctagaaactg 601 agacactcaa caagtatgtt gtgatcatcg cctatgccct agtgttcctg ctgagcctgc 661 tgggaaactc cctggtgatg ctggtcatct tatacagcag ggtcggccgc tccgtcactg 721 atgtctacct gctgaacctg gccttggccg acctactctt tgccctgacc ttgcccatct EPI-109 731

781 gggccgcctc caaggtgaat ggctggattt ttggcacatt cctgtgcaag gtggtctcac

841 tcctgaagga agtcaacttc tacagtggca tcctgctgtt ggcctgcatc agtgtggacc

901 gttacctggc cattgtccat gccacacgca cactgaccca gaagcgtcac ttggtcaagt

961 ttgtttgtct tggctgctgg ggactgtcta tgaatctgtc cctgcccttc ttccttttcc

1021 gccaggctta ccatccaaac aattccagtc cagtttgcta tgaggtcctg ggaaatgaca

1081 cagcaaaatg gcggatggtg ttgcggatcc tgcctcacac ctttggcttc atcgtgccgc

1141 tgtttgtcat gctgttctgc tatggattca ccctgcgtac actgtttaag gcccacatgg

1201 ggcagaagca ccgagccatg agggtcatct ttgctgtcgt cctcatcttc ctgctttgct

1261 ggctgcccta caacctggtc ctgctggcag acaccctcat gaggacccag gtgatccagg

1321 agagctgtga gcgccgcaac aacatcggcc gggccctgga tgccactgag attctgggat

1381 ttctccatag ctgcctcaac cccatcatct acgccttcat cggccaaaat tttcgccatg

1441 gattcctcaa gatcctggct atgcatggcc tggtcagcaa ggagttcttg gcacgtcatc

1501 gtgttacctc ctacacttct tcgtctgtca atgtctcttc caacctctga aaaccatcga

1561 tgaaggaata tctcttctca gaaggaaaga ataaccaaca ccctgaggtt gtgtgtggaa

1621 ggtgatctgg ctctggacag gcactatctg ggttttgggg ggacgctata ggatgtgggg

1681 aagttaggaa ctggtgtctt caggggccac accaaccttc tgaggagctg ttgaggtacc

1741 tccaaggacc ggcctttgca cctccatgga aacgaagcac catcattccc gttgaacgtc

1801 acatctttaa cccactaact ggctaattag catggccaca tctgagcccc gaatctgaca

1861 ttagatgaga gaacagggct gaagctgtgt cctcatgagg gctggatgct ctcgttgacc

1921 ctcacaggag catctcctca actctgagtg ttaagcgttg agccaccaag ctggtggctc

1981 tgtgtgctct gatccgagct caggggggtg gttttcccat ctcaggtgtg ttgcagtgtc

2041 tgctggagac attgaggcag gcactgccaa aacatcaacc tgccagctgg ccttgtgagg

2101 agctggaaac acatgttccc cttgggggtg gtggatgaac aaagagaaag agggtttgga

2161 agccagatct atgccacaag aacccccttt acccccatga ccaacatcgc agacacatgt

2221 gctggccacc tgctgagccc caagt

(2) INFORMATION FOR SEQ ID NO: 2563: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 541 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2563:

1 ccgctgtcaa gatgcttctg gccatggtcc ttacctctgc cctgctcctg tgctccgtgg 61 caggccaggg gtgtccaacc ttggcgggga tcctggacat caacttcctc atcaacaaga 121 tgcaggaaga tccagcttcc aagtgccact gcagtgctaa tgtgaccagt tgtctctgtt 181 tgggcattcc ctctgacaac tgcaccagac catgcttcag tgagagactg tctcagatga 241 ccaataccac catgcaaaca agatacccac tgattttcag tcgggtgaaa aaatcagttg 301 aagtactaaa gaacaacaag tgtccatatt tttcctgtga acagccatgc aaccaaacca 361 cggcaggcaa cgcgctgaca tttctgaaga gtcttctgga aattttccag aaagaaaaga 421 tgagagggat gagaggcaag atatgaagat gaaatattat ttatcctatt tattaaattt 481 aaaaagcttt ctctttaagt tgctacaatt taaaaatcaa gtaagctact ctaaatcagt 541 atcagttgtg attatttgtt taacattgta tgtctttatt ttgaaataaa t

(2) INFORMATION FOR SEQ ID NO: 2564: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2761 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2564:

1 atatatatat gcataatagt ctctgtgtaa cagtaagtgg atgcagtaac tggtgtgagg

61 gcaacttgga gagtgtgctt ggaggcacag agatgctcag ggctgcctgg actgcctcca

121 tgatggtggc ctgctctgta ttaggtgagt gttcaggaaa ggtgagggca gggcagccca

181 cagcttcaca gtggcccagg gaagcagggc aggcaggcta tgaggcctag taggcatctg

241 ggccagactt tgacactgag gccatggaat gggtggggct ctgagaacag acccaagtga

301 tcatgggctg aaggctatgt ccacagatcc aaggcgggat aggctgtact gggcagtgat

361 gtcagccagg ctccccagcg ggactggggg tgtcaggggc agctctgtcc caggtggcag

421 acactggttt cccctcctgc tctcacaacc ggcctgttac caggtgttgt ctgagctgtg

481 gtgaggcttc cctggtgaca ttcaggagca gggagcctgc gagtaagggt gtatgcatct

541 gccctgactg cctggccctg tggtcaagga tgggggaagg cagctctgcc tgcagctcca

601 ccccatttat aaagcactgt ggtgccttct gctgggacat gtgctgagtg gtgcctcgca

661 ggcactgccc tcgggaagtt cacaggctta tgtggaagct ggtgggaatg ggccaagaag

721 agaggtgtca ggagccaggt attgggcagg tcccaggtct ctgagcctca gtttcttcat

781 ctgtaggagg gtggtgaccc tgccctgctc agcttaccag gtacagatgt aagttttcag

841 tgcagaggaa aagcagagaa cttcccctca gatggccata cccccttgtc gctgtaccca

901 actctccggt cctactttgt agctctcagg tgtcacatgt ggatcctgcc ctaccatccc

961 ccttgccctg tctagaaacg aggcctgctg agcttggaac catcccactc cctgctctca

1021 agccgtctgc tcctgggtta gcctgtggct gacctggcct gattctacat agatgtgggt EPI-109 732

1081 gtttctccac tgctggggca gcagttgtcc attctggggc ctgggtcagc tctcagctgt 1141 ggccgttgtg cctgtgcttc cccaggtcct ggtggtgact ccaaccctgc cctcacatat 1201 cccaagagca ggctgactgc cttccccatt cccacctttc cagtaactgc tgcaagaacg 1261 gacagacact gctgcagaga acttgccacg gtgtttcatg ctgtggctgg tggttccagg 1321 ctgcacgctc cattctagga aagggtgagg cttcctgatc atcagtctta acaggggact

11381 gtcctatggg tacctgtata cgctgccggg agtggggcag agtggggtta gagtagtgcc 1441 tgctgcccat tggggttgtg cgggttcctt aagggctgta gtctgtgtgc gtgtctggtt 1501 ttttcctcct ccttatcagt aatcagtctt gtataaccag gctggccctg cttcctgcct 1561 aggggctatc ggtgtaccat ctggagttgc aaatggggtg atagggcgtc agcggccttc 1621 ccacacccaa gcacttcctg acacccagcc cctcatctct agccaacctc tggctcccct 1681 agggatcctg gggctcaggc ctcacgctcc agcatccggg ggctttgccc ttctggtgtt 1741 gctcttcttt gcaggtgcct tggaacaggg gtgcaacaga gttcagaaag tgccatctgt 1801 tgcatggata ccctgctgcc accctcgtcc acctttctgg ggcagaacag ttggatgggt 1861 ctttatttaa gaggacaaaa gggagagaga atgcatagag gctgggtctg gtggctcacg 1921 cctgtaatcc caacactttg ggaggccaag gcaggtggat cccttgaggt caggaggtca 1981 agactagcct ggccaacatg gtgaaacccc gtctctacta aaaatacaaa aaaaaaaaaa 2041 ttagctgggc atggcgggag atgcctgtaa tcccagctac tcgggaggct gaggcaggat 2101 aatcacttga acccaggagg cggaggttgc agtgagccaa gatcacacca ctgcactcta 2161 gcctgggtga cagagggaga ctgtctcaaa aaaaaaaatt tgcttagaat ttgtctgtgt 2221 gaccctgggc aagtcatttc ccctccttgg gactcagttc cttgcctgtg aacggggaca 2281 gtgcttctcc cttacagagc tgttgtgaga attaaagtag aaaatgtacc tatggtggtt 2341 gttggtagtg accagttccc ccaaccctga ctcccctgca ggatggggcc tgggcccggg 2401 aatgggggat gggctggcag aggatgactg tcccagagag gagtcttctc ggcagatgtg 2461 gagacctagc tgagtcagag gccaggatct aagtttgagg gtgttcctta caccctgcag 2521 ccatgagtct ttggctgagt caaatggcct ttctgagctc agttccttat cagtaaagcc 2581 tggacagtgg tccaggacgc tggacactgt gtgagtgtta ggacacagga cactgtgtga 2641 gtgcaggtgg ggacccatgg agcactctgc tggggagcaa ttcatgggga gcacccctcc 2701 agagagggat gatttgcaca gggccctcag cccagtccct tgcaggctgg accttggaga 2761 gtgaggccct gaggcgagac atgggcacct ggctcctggc ctgcatctgc

(2) INFORMATION FOR SEQ ID NO: 2565: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17041 base pairs

(B) TYPE: nucieic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2565:

1 ggatccatgc ccagaattat tcacgaaatt cacttaaaat agcatatatg cttgaaccca

61 ggagtctgag gctgcagcga gctatgatca tgtcactgca ctccagccca gcctgggcga

121 cagagcaaga ctctgtgtct aaagaaatga aaataaaaat aaataaaata gcatatacag

181 gcaacaatcc aaatgttcat tgcagaaatt atgattatta ttgtttttct tttagaggca

241 gggtgtcact ctgttgccca gactaatctt gacctcctgt gatcctcaag agatcctccg

301 gtctctgctt cccaaagttc ttggattaca ggtgtgaggc actgggccta gacattgcag

361 ggattattaa accatggtgc atactaccat taaaggtatg aggtaggttt tatatgctga

421 cctagaaaga tggtgcaaca ccatagggga acaagaaggc tgcaaagtgg cagcacagca

481 ggagtcttta agaaataggt atttgtttca gcttaagaag tgtctggctg ggcgtggtgg

541 ctcacacctg taatcccagc acttagggag gcttaggtgg gcggatcact tgaggttagg

601 agttcaagac cagcccagtc aacaccggtg aaaccccatc tctactaaaa atacaaagaa

661 attagctggg cttggtggca ggtggctgta atcccagcta ctcaggagct gaggcaggag

721 aatcatctga acccgggagg ccgaggttgc agtgagccta gatcgcacca ctgcactcca

781 gcctgggtga cagagtaaga ctcggtcaaa aaaaaaaaaa aaaaagaccg ggtgcgaggt

841 ctctcgcctg taatcccagc actttgggag gcctaggcag gaggatcaca aggtcaggag

901 atcgagacca tcctggccaa catggtgaaa ccccatctct actaaaatac aaaaattagc

961 cgggtgtgat ggcacacgcc tgtagtccca gctactcagg aggctgaggc aggggaatcg

1021 cttgaaacca ggaggtggag gctgcagtga gccgagatca cgccactgca ctccagcctg

1081 gcgacagagc aagactccat ctcaaaaaag aaaagaaaac aaacaaacaa acaaaatccc

1141 caaaaagcaa aagtgtctgc atggacttgt gcctaactac tcacagtggc tacttcttgg

1201 gggaggtgaa aggggaccct gttaaagaat ttttcttctg tattgttttt cttcaactga

1261 gtctgcatta attttatatt taatactctc cccacccctg atgctcacag gttgctttag

1321 ctggtggaag gagaacctgc acctctggtt ttggcaaagt gtagaagggg acaagggcac

1381 tgctctgcac ctgcacaggt tcttgcctcc tggggtcagt ttaatgaatc tcagtggtgt

1441 ttcttgggaa gaacacagtg gacactcact tgccagtcag tagacaaatc actgaagtcc

1501 atgtctggca gttctcaatg tcatggggac tgtaaggttg tcatgtctca cagttccctg

1561 acttagaaga ttagtggtga cagacacttc tcagctctgc tcgggagagc agctctgtaa

1621 tgcgcttgtg gtttcagatg tgggcggcct gtgtgaacct gtcgtgcaaa gctcacgtca

1681 ccaactgctg cagttatctc ctgaatcagg ctgagggtct ttgctgtgca cccagagata

1741 gttgggtgac aaatcacctc caggttgggg atgcctcaga cttgtgatgg gactgggcag

1801 atgcatctgg gaaggtgagt ctgtgctttg ggcttcccaa cctctcaagt cagcatgaaa

1861 ttcagaaggc agagagggac atgtggccct ccaactcggg gcccagggag ccactgtggc EPI-109 733

1921 atttgagagc gccaccctag ctttacctcc tctggtgtcc tggccttgtg tatctcttag 1981 agatggcaaa atttgcagcc ctgacctcaa ggattacaaa ctaatttcca gtcctgtagg 2041 ggtcatgggt tctgctgtgg ccagtgtggc actgagtttg tcaggcagaa tttctaatta 2101 tggaaggaac tctgcttcct cagtgattga actgaccttt gtgggggtgc ctttgtgggg 2161 tgagaatggg catacttggg cctcagttgt gatggccatg gggtggagct gaggtctagg 2221 cccagggctg ggaaagcttc taccaacccc gaggcatttg ggtgttttag ggcagaagag 2281 gagccaggag gatgggtatg ccccactgga gctgtgtgtg gggcagcagg tgagggtggg 2341 attccagagg gagggtcaac ccagccaagc agaggaaggg gaggagaggg tttgttttgg 2401 aaagaacatc accctctcag tttcctgggg tctggatagc ctgttcttgt gatgagctgg 2461 aggatgtggg ccctgcttgg atcctcctct cccctccctg cccccatttt ctcttcctgt 2521 gatttatgct gttctgσgct caccctcttc ccagagctct cacgctacag ctgacaggca 2581 gggcaggcgt tttaattatt attaattttt ttttgagaca gagtttgaga cagtatcaag 2641 agtgggtatc ctctcagcgt gtcttcaagt agcatcccag agccccgctc ctgggtaccc 2701 acaacatgaa caccgtccag aagcaagggc agcctctgca ggtggggcgg gggttggaaa 2761 acatttatca aacggttgag ttgggtgcag gggatgcaac atgatcaaac agggtcttgc 2821 ctccaggagc ctcatgtagg gacaacgcac agtgatgacc ttcaactgca gtggggcagc 2881 aaggctgtgg gaggggtgtt ttgggcagag caggcgacgt gggtacctct tcaccaagac 2941 agcaggaaga gcacggacat cattttcccg tctcacctcc agactcccag gggactgtgc 3001 caatatcctc actggagccc tgcccatggc cactgctcaa cccttgggcc ctgtcagttc 3061 agggctgtgc agaaggagag ttgcctgtgc tcaggctcag gggttccgtc cagctaagga 3121 ggcctactag gggactgggg aaaggcctca tgaaggacca ggcctgtgat ggggagggaa 3181 gatggcagag gggacagtgg gaagcagagc agcaggggtc tcctccacgc ctctctgtac 3241 ttctcccacc cacccttgcc tgctcccctc tgccctgggt atgtgccctt gtccacccaa 3301 cacctctgca gtgccaagtc cagccctgac ttcttcctga gctgtggccc agcgttccca 3361 caggcattta cctcacggat gcagcactgc ccctcatcct cttctctgaa agtgtgtggg 3421 aaatgcttct tggtgccatc tctctcccac cctgccttcc ctgcaccttc tctatgaggt 3481 gtctgttgtc tctgtacttg cctccagctg gcctttcaga ccccatccct ccctgcctcc 3541 tgcccatccc tacccctgtc agcaccttac atactctgtg cccaacagca ttggggattc 3601 ccactgtgct gaaggaagtc ctcatgtggt ccagagaggg agctggcccc tgctcccatt 3661 tccagcacca ttttctggca caggctccat gtccccaggc tccagctgct tctggggtac 3721 caaggtctgc atttcttcct cttcccccag cagacagaag accttgctgg acaggtgtcc 3781 acttcaatag taacttctga ggctgccagc ctcctgaatg gtccagaaga accagaccct 3841 tccccgcccc cattaaaaaa gacaaaatat ggccaggcat gttggctcat gcctgacatc 3901 ccagcacttt gggaggccaa agcaggtgaa tcacttgagg ccaggagtac gagaccagcc 3961 tgacaaacat ggtgaaaccc tgtgtctact aaaaatacaa aaattagcca ggcgtggtga 4021 ctcatgcttg taaatgcttg taatcccagc tacttgggag gctgaagcag gaggatcact 4081 tgaactcggg aggcagaggt tgcagtgagc cgagatcacg ccactgtgtt ccagcctgag 4141 cgacagagcg acactccgtc taaaaaaaaa aaatatatat atatatacac acatatatat 4201 atgcataata gtctctgtgt aacagtaagt ggatgcagta actggtgtga gggcaacttg 4261 gagagtgtgc ttggaggcac agagatgctc agggctgcct ggactgcctc catgatggtg 4321 gcctgctctg tattaggtga gtgttcagga aaggtgaggg cagggcagcc cacagcttca 4381 cagtggccca gggaagcagg gcaggcaggc tatgaggcct agtaggcatc tgggccagac 4441 tttgacactg aggccatgga atgggtgggg ctctgagaac agaccaaagt gatcatgggc 4501 tgaaggctat gtccacagat ccaaggcggg ataggctgtg ctgggcagtg atgtcagcca 4561 ggctccccag cgggactggg ggtgtcaggg gcagctctgt cccaggtggc agacactggt 4621 ttcccctcct gctctcacaa ccggcctgtt accaggtgtt gtctgagctg tggtgaggct 4681 tccctggtga cattcaggag cagggagcct gtgagtaagg gtgtatgcat ctgccctgac 4741 tgcctggccc tgtggtcaag gatgggggaa ggcagctctg cctgcagctc caccccattt 4801 ataaagcact gtggtgcctt ctgctggggc atgtgctgag tggtgcctcg caggcactgc 4861 cctcgggaag ttcacaggct tatgtggaag ctggtgggaa tgggccaaga agagaggtgt 4921 caggagccag gtattgggca ggtcccaggt ctctgagcct cagtttcttc atctgtagga 4981 gggtggtgac cctgccctgc tcagcttacc aggtacagat gtaagttttc agtgcagagg 5041 aaaagcagag aagttcccct cagatggcca tacccccttg tcgctgtacc caactctccg 5101 gtcctacttt gtagctctca ggtgtcacat gtggatcctg ccctaccatc ccccttccct 5161 gtctagaaac gaggcctgct gagcttggag ccatcccact ccctgctctc aagccgtctg 5221 ctcctgggtt agcctgtggc tggcctggcc tgattctaca tagatgtggg tgtttctcca 5281 ctgctggggc agcagttgtc cattctgggg cctgggtcag ctctcagctg tggccgttgt 5341 gcctgtgctt ccccaggtcc tggtggtgac tccaaccctg ccctcacata tcccaagagc 5401 aggctgactg ccttccccat tcccaccttt ccagtaactg ctgcaagaac ggacagacac 5461 tgctgcagag aacttgccac ggtgtttcat gctgtggctg gtggttccag gctgcacgct 5521 ccattctagg aaagggtgag gcttcctgat catcagtctt aacaggggac tgtcctatgg 5581 gtacctgtat acgctgccgg gagtggggca gagtggggtt agagtagtgc ctgctgccca 5641 ttggggttgt gcgggttcct taagggctgt agtctgtgtg cgtgtctggt tttttcctcc 5701 tccttatcag taatcagtct tgtataacca ggctggccct gcttcctgcc taggggctat 5761 cggtgtacca tctggagttg caaatggggt gatagggcgt cagcggcctt cccacaccca 5821 agcacttcct gacacccagc ccctcatctc tagccaacct ctggctcccc tagggatcct 5881 ggggctcagg cctcacgctc cagcatccgg gggctttgcc ttctggtgtt gctcttcttt 5941 gcaggtgcct tggaacaggg gtgcaacaga gttcagaaag tgccatctgt tgcatggata EPI-109 734

6001 ccctgctgcc accctcgtcc acctttctgg ggcagaacag ttggatgggt ctttatttaa 6061 gaggacaaaa gggagagaga atgcatagag gctgggtctg gtgtcacgcc tgtaatccca 6121 acactttggg aggccaaggc aggtggatcc cttgaggtca ggaggtcaag actagcctgg 6181 ccaacatggt gaaaccccgt ctctactaaa aatacaaaaa aaaaaaaatt agctgggcat 6241 ggcgggagat gcctgtaatc ccagctactc gggaggctga ggcaggataa tcacttgaac 6301 ccaggaggcg gaggttgcag tgagccaaga tcacaccact gcactctagc ctgggtgaca 6361 gagggagact gtctcaaaaa aaaaaatttg cttagaattt gtctgtgtga ccctgggcaa 6421 gtcatttccc ctccttggga ctcagttcct tgcctgtgaa cggggacagt gcttctccct 6481 tacagagctg ttgtgagaat taaagtagaa aatgtaccta tggtggttgt tggtagtgac 6541 cagttccccc aaccctgact cccctgcagg atggggcctg ggcccgggaa tgggggatgg 6601 gctggcagag gatgactgtc ccagagagga gtcttctcgg cagatgtgga gacctagctg 6661 agtcagaggc caggatctaa gtttgagggt gttccttaca ccctgcagcc atgagtcttt 6721 ggctgagtca aatggccttt ctgagctcag ttccttatca gtaaagcctg gacagtggtc 6781 caggacgctg gacactgtgt gagtgttagg acacaggaca ctgtgtgagt gcaggtgggg 6841 acccatggag cactctgctg gggagcaatt catggggagc acccctccag agagggatga 6901 tttgcacagg gccctcagcc cagtcccttg caggctggac cttggagagt gaggccctga 6961 ggcgagacat gggcacctgg ctcctggcct gcatctgcat ctgcacctgt gtctgcttgg 7021 gagtctctgt cacaggggaa ggacaaggtg agggctgggc actaatgtct gtatgaggtg 7081 ggtggagaac tagggcatgt ttgggggact gggttgtccg atgtcaagcc tctagggaaa 7141 ggtttggccc aaactgtgct ggggcatgtc ctctaggggt cagcctggac ctcagtctct 7201 agtctcccta cttttacctc cctaccttca ttccctggac cgactgtagt ctcccttcct 7261 tcactctctt gacgcctctc cagatctgac ttgcccgtgt accacaggtc agagcccatc 7321 acttcccagg cctcccagtg cttccctgga cagattctgg gatcatttac tggtgactgc 7381 cctgctaggg tgtcagctgt cagatcctcc ccaacccccg agctcagctc tggcctgaag 7441 tacttaccgt gggctcctga tggtcactgt ctccagggcc aaggtctaga accttcacct 7501 gcctcaccaa caacattctc aggatcgatt gccactggtc tgccccagag ctgggacagg 7561 gctccagccc ctggctcctc ttcaccaggt gagcatggag ggccatgccc acctggacag 7621 ggatgagggt gagttcccca ggattgaagc agctatgcca ggacagtgta gcagccccgt 7681 ggtgctgaca aatgcccttt ccagcaacca ggctcctggc ggcacacata agtgcatctt 7741 gcggggcagt gagtgcaccg tcgtgctgcc acctgaggca gtgctcgtgc catctgacaa 7801 tttcaccatc actttccacc actgcatgtc tgggagggag caggtcagcc tggtggaccc 7861 ggagtacctg ccccggagac acggtgagca gcagctatag gtctggggcg gggccgcttg 7921 gcaagaacat cctggctgct tgggggtttg gagcagggcc ttgcagcctg tgagtggccc 7981 agtgagtgtt ctcagtccca gccgagtgag atccagggct gggggcaggc ttggcccttg 8041 ggaggggagg gcccatatgg ttactgcagg ggcagggttt tggcaggaaa taaacatgca 8101 cggctgctag ttggggcagg ggctggcact tgagtcatgt gaaatgcact tcagtcatac 8161 caggaaggac tccaataaga tgctgggaaa agcttccagc agcagactgt gaaggaaagg 8221 gaaagcaaga tttagaaacc acctagtcta ggtgcagagg ccagaggaag tcattgctgt 8281 cctgtcccgc ctggggcttt tgtggaccag tctcccagtg aggtgcctgg tctgagaggg 8341 ccttgaccat tccccttggg agtctttcag accccagtct tgtgtgttct gactgacaca 8401 cccagaccca tggggcttca gcctcacatg gattcactct gttccagtta agctggaccc 8461 gccctctgac ttgcagagca acatcagttc tggccactgc atcctgacct ggagcatcag 8521 tcctgccttg gagccaatga ccacacttct cagctatgag ctggccttca agaagcagga 8581 agaggcctgg gaggtaacac tttggctggc tttccctggg ggcctctctc ctgggaacag 8641 cagtccaggg tagactcccc actctacata gggagatgtc aacttgtagt gatgagaagg 8701 gaggaactag agcggggtgt gtgtgcacac acacatgctg gcatgcagat gtgtatgctt 8761 tatgtgtgtg tatgggagta gggtgagtgc gcctgtgtct ctgtgtgtgc acataagtgt 8821 ggtgagtgtg catgtatgtg tttatgtgta cacatatgta actgtgcaca ctcatgtttg 8881 tgtgcccatg tttgtgtgtt tatatgtaag tgtacatatg tgtgtgcctg tgccttgcat 8941 ttgtgtgagt gtgcacatgg gcatgcctat gtgtatgagt gtgtatgtga gtgtggtgag 9001 ttgcttctgt gcacacactt ttgtttatga gtgtgcatgc aagtgtgatg agtgtgaaag 9061 tgttcctgta gacatgtttg cctgtgtgtg catatgtgta tttgtgggca aacgcagctg 9121 tgtctgtgag tgtgagtgtg ccttctgtgt gtgtgtgtgc acgtgaatgt ggtgagtgtg 9181 tctgtgtgtt aacacaagtg tgttcaagag tgtgttatat gagcatataa tgcatgtgtg 9241 tattctcgag ggctgaggga cccagcccca ccttcaccac ctgctaactg tccccacccc 9301 cacagcaggc ccagcacagg gatcacattg tcggggtgac ctggcttata cttgaagcct 9361 ttgagctgga ccctggcttt atccatgagg ccaggctgcg tgtccagatg gccacactgg 9421 aggatgatgt ggtagaggag gagcgttata caggccagtg gagtgagtgg agccagcctg 9481 tgtgcttcca ggctccccag agacaaggtg ggcactgctg tggctgctgc acttccagcg 9541 gagtctgggc tgggcgtctt ctcccctgtt cacctcagcc ctgcaccctt tcaccctcct 9601 gtaagcccct ccccgaggca gccatgcctc agttgacccc cttcctctga aggtctgagg 9661 tctgtaggga ggacagaaac acctgccaac tctggggctt cctgggaacc tgtagttagt 9721 ggctgctgtt aggagtgagg gtggcagggc tgcacaccag ggctgggctc ctgcctggag 9781 gctggacatg acctcagtgt ccttaatggg ggctggactg acccttgcgc actgcagtgc 9841 tgagatggcc cagggacttt atgacccacc ttgtggcaga tgggaagagt gaggcccagg 9901 agtgtggttc acacaaggtc cttcagcagg tgacacaaac ctccaaggcc catcacaagg 9961 tccttcagca ggtgacacaa aggtggaagg cccatcacaa accttccact ttggcccagg 10021 gcactaaagg gcgcaccttt gccaggtggg tttgggggga gcctcctggc actgaggctg EPI-109 735

10081 ctcacagccc tgggcccttc ctgtccacag gccctctgat cccaccctgg gggtggccag 10141 gcaacaccct tgttgctgtg tccatctttc tcctgctgac tggcccgacc tacctcctgt 10201 tcaagctgtc gcccaggtag gtggctgatg tgtgcgtgtg tgtacatgtg tgagcgggca 10261 agagtgtgca tgttagtgta tgtgtgcaga tgtgtgactg tgtgcatgtg tgagtgtgtg 10321 gtgggtgggc catcaagggc cgcccttgtc tggttcctcc cctcccctct ccactgcctg 10381 gtcctggacg gggtgggctt ttcgagtctc caccctggtc cagaagaggg ttctcaagtt 10441 gccaggggag agcagggaag gggggtctga ggcagaggct gaagataagg gcagcttggt 10501 cccgaccaga cccagagtca ccgagatcaa gagccggagg tcctagtctc ctgcctctgg 10561 aggagcttgg tttgttcatt tgttcacatg ttctacgaaa ggacagttgg ggcatctggt 10621 gtgctcagga ccctgttctc agaacaagat ggacaagggc cctccttaaa taaaccgtca 10681 cgcctcatgc accacatgtc aggttacaag acagggtgca ggggccatgt caggccgcag 10741 atgtgaggaa gagggtgtgg ggagaggggt gttgggtggg gctaagtggg agggtgcttc 10801 gcttctcctt ggagcaaagg aaagtgtaaa actgtgtgac acaacctagt ttatgttttg 10861 aggaatagat tgctgggaca aggggacatg ggggacctgc tggaggccaa tgggggccag 10921 tgaggtgccc acagggagac gatttgcatg agccagtgaa agaagtggag atagagaaaa 10981 gtggagagaa ttgcagggtc tcatgagggg aaatagaagg gacatgtggg tggatgagat 11041 atgagtggtg acccctgagg tggggaaatg ggggacagcc ttgcagggag gttggtgaag 11101 tctatttgga cctgttgggt tggagcccca ggtgacatcc ttgtgggagg gtcagtggat 11161 ccttggcagc aagtctggtg ctcagggaga cactgggtgg ggtgggagcc acagaccttc 11221 tgctgatggc aaagacaggg ttcctggagg tgctggctcc ctctgtgatc tgaggaccca 11281 gctagtaact ccccgttctg aacccgccat cgcagctcac gctgtaaagg acgcgcgcct 11341 cagtataaat cagttctatg cggccgttag gcaaggaggc ccagttgggt cctgccctga 11401 gagtgggttg gaatgtgatg agatgggaga gaggcagtgg cagggacgag gtgggcggac 11461 ctcctgctga tggaaggaag ctcagcctct gcagtgacct caggccacct gggtcgccat 11521 aggcctctga ctggcctctc ttggcctcag ggtgaagaga atcttctacc agaacgtgcc 11581 ctctccagcg atgttcttcc agcccctcta cagtgtacac aatgggaact tccaggtgtg 11641 tgcagagacc acagaaggac atggggggca ggggttgccc agagctctgg cctgcccaag 11701 atgttggctt tcatgagggt tggcggccag tatgggaggc ttgtcagtgc ttggagcctt 11761 ttttgtatat tcagtgaatt tcaatttata cgcgtatctc aaatggggaa aaattagctt 11821 tattttccat tgctgatttc tttttgttct caggtctcta gttccattgt tgattgaaaa 11881 aatgtaaatt tctcataact tatctctgtc ccctctggtt tgcagctttc tgcacccacc 11941 atgtgcctca cctcctcctt ctgcgaaggt gtctgtcctg tggccatggg gaagggtctg 12001 tggtgtgtgt gctgcccttg gggctctcac tgcctctggg ctcctgctct gcctggtccc 12061 ctggtctccc cggatcacat gatggcacca cagctgagga gtgggctctg cacttccccc 12121 ccttccaccc atgttgggct cctacagccc aggcaccagt gagcaacttg ggggttgcat 12181 cagcccctcc cctccctgct gggctgttgg ttcatgcccc ctgggtggga ggagggggag 12241 agggagagct ccagtgagtg gtctctggtt tttcccctca gactcctcac tttgggcaaa 12301 ggacaagagg cagtgagggc ccctccctgg ggtctgggcc aagctgacca ctcttctcca 12361 gaatcttccc tccctgtccc cttcacactg tggctccagc ttactatgca gaaaaatcct 12421 tttctctctc aatgaggagc gtagttttca agatttttgt ccaaaaatat aatttgaacc 12481 atgaaccggg catctggctc ttggcagagt ctccctcttt ccccaaggtg gtagatgtga 12541 ctgtcaggag cctgggcagc tgacgacaag gctgagcagg tcagattgtg actgtcccct 12601 ggactgtcat cctgttgcgg gcaccagctg ttccctagag aactaggaca cctgccacgg 12661 gttatttaga ctgcgggtga ggatctggtg ccataggttg gtctccaggg agcactgcag 12721 tgatggaggg tgttgtgtgt gtgatgcatg ggatggaggc tcctggtccc accaagggaa 12781 cagcttcctt ttggaggcgg gggcctcctg tggccccaca gaaggatcca ggtctgctgg 12841 ccatagccga gtgctttgaa agtcaccagt cctgacagcg attcgtgtgt gtgtctgtgt 12901 gtgtgtgtgt gtgtttatgt gtctgtgtgt gttcgtgtgt gtgtctgtgt gtgtgtttgt 12961 gtgtgtatgt ctgtgtgtgt gtgtttatgt gtgtgtgtct gtatgtgttt aagtctgtgt 13021 gtgtttgtgt gtgtgtgtct ctgtgtgtgt gtctgtatct gtgtgtgttt gtgtctgtgt 13081 gtgtttgtgt gtgtgtctgt gtgtgtctgt gtgtgtgtct gtgtgtgtgt ttatgtgtct 13141 gtgtatgttt gtgtgtgtgt ttgtgtgtgt gtgtttgtgt ttatgtgtgt atgtctgtgt 13201 gtgtctgtgt gtctgtgtgt gtatgtgtct gtgtgtgttt atgtgtctgt gtgtgttcgt 13261 gtgtgtgtct gtgtgtgtgt gtttgtgtgt gtatgtctgt gtgtgtgtgt gtttatgtgt 13321 gtgtgtctgt gtgtgtttat gtctgtgtgt gtttgtgtgt gtgtgtctcg tgtgtgtgtg 13381 tctgtgtgta tctgtgtgtg tttgtgtgtg tgtgtgtctc tgtgtgtgtg tgtgtttgtg 13441 tatgtttgtg tgtgtgtgtg tgtgtgttgg gaatgcccag tctctgcagc tgctgaaagg 13501 ccctgaggca catgctgtca ggagctggct ctgtcctggg cagatatcac catctgtacc 13561 tcggttcagg ctgccgtggg caccaggccc tgtgctgggg gagtgctgag gagcctgaag 13621 ggactcaggg tcccgtgatg aggctgggct ggcacatgga ggaaagacag aatgtccaag 13681 acacaggcgc tgcttggcct ctgggtgtgg acctcaggag ggcttcctgg aggaggaggg 13741 atgctgggct tgccagaaag gaggcagctg ctcccaggat gagttctgaa catgctacct 13801 gagcccttcc ctcctcccgt gctctgttcc agacttggat gggggcccac ggggccggtg 13861 tgctgttgag ccaggactgt gctggcaccc cacagggagc cttggagccc tgcgtccagg 13921 aggccactgc actgctcact tgtggcccag cgcgtccttg gaaatctgtg gccctggagg 13981 aggaacagga gggccctggg accaggctcc cggggaacct gagctcagag gatgtgctgc 14041 cagcagggtg tacggagtgg agggtacaga cgcttgccta tctgccacag gaggactggg 14101 cccccacgtc cctgactagg ccggctcccc cagactcaga gggcagcagg agcagcagca EPI-109 736

14161 gcagcagcag cagcaacaac aacaactact gtgccttggg ctgctatggg ggatggcacc

14221 tctcagccct cccaggaaac acacagagct ctgggcccat cccagccctg gcctgtggcc

14281 tttcttgtga ccatcagggc ctggagaccc agcaaggagt tgcctgggtg ctggctggtc

14341 actgccagag gcctgggctg catgaggacc tccagggcat gttgctccct tctgtcctca

14401 gcaaggctcg gtcctggaca ttctaggtcc ctgactcgcc agatgcatca tgtccatttt

14461 gggaaaatgg actgaagttt ctggagccct tgtctgagac tgaacctcct gagaaggggc

14521 ccctagcagc ggtcagaggt cctgtctgga tggaggctgg aggctccccc ctcaacccct

14581 ctgctcagtg cctgtgggga gcagcctcta ccctcagcat cctggccaca agttcttcct

14641 tccattgtcc cttttcttta tccctgacct ctctgagaag tggggtgtgg tctctcagct

14701 gttctgccct cataccctta aagggccagc ctgggcccag tggacacagg taaggcacca

14761 tgaccacctg gtgtgacctc tctgtgcctt actgaggcac ctttctagag attaaaaggg

14821 gcttgatggc tgttcccaaa gtgttgatgg ctgggagaag gggccagagg aggagtgagg

14881 ggtggggttt gtccagccct gggctttccg ggctctagag atagcatggt gtaggctcaa

14941 tgacagttct ggggacagca agttggaggt tcaggggcag cttcaggaca gcaggatgga

15001 ggctcaggga caattcctgg gaggccagtg ccctcgttcc tccttgtcct catcctcccc

15061 cttgctccag gaaactgaga gctgagcctg gagcttccag acagtcagtg ctgggggtga

15121 ccatccagca gtgatggtgg cctgtgaagg gtcctgcttc tgtcctcagc ctctcatggg

15181 gtgggcttgt ggaggagctg tggtctggag agagtggcag ttggagcaga acgtgcctgc

15241 gtttgtttcc tagggctgtc gtaacaaagt gccacaaaat ggttagctta gaaccacaga

15301 gatttgttgt ctcacaattc tgaagtccag aagttggaaa taaagatgtt ggcagtgttc

15361 ccaaccacat gttcttgggc tcccatgaaa cagaagttga tattaggcca aggaagcttc

15421 ccagacaaga ctttattaag tcttatgccc cgaaagtttg ggcagaagag agacggtgca

15481 ggaggaagaa ttcttggctg actccccaag gggaatgcat tgtggtgtct taaggagggt

15541 gacatacata atttatgagc tacatgagtg tcattgcaca tatggggtgg agcgaagggt

15601 gctcagacgc atgctaacac atacgttgca tgatcagaaa atggcagata agcccctccc

15661 tgggtgagga ctttagtatt atcataagac cagggtcatt ctcctggcct tgtgcacaag

15721 caggtgatgg agtcaactcc cgtcagtaag acttatggcg ggatgctgct tatcttagtt

15781 tatttcagac agttggcaag gtctggccag cgagtatggc acctggaggg tggtgctgca

15841 aggtctagtg gtcagcgggc acgtatggaa caatacgtta gtgggggtgg gccgagtccc

15901 atttatactc tctcagcagg gccatgctcc ctctgaaggc actagggaag gattagtttc

15961 aggcctctct tcagcttctg ttagtttctt ggcttgtgac accaaagctg taatctttct

16021 tttgttttgt ttttgtgacg gagttttgct cttgttgccc aggctggagt gcaatggcac

16081 aatctcggct cactgcaacc tcctcctccc aggtttaagc aattcttctg cctcagcctt

16141 tggagtagct gtgattacaa ggcacctgct accacgcctg gctagttttt gtatttttag

16201 tagagacggt gtttcgctat gttggccagg ctggtctcaa actcctgata tcaagtgatc

16261 cgtctgtctc tgcctcccaa agtgttggga ttacaggcat gagccaccgt gcctggccaa

16321 agttccagtc tttacaggga tttttccttg tgtgcatttc tgtgtccaaa tttccccttt

16381 ttaaaatcac aataatagtg aattaaggct ggccctaacg atttaatctt aacttgatca

16441 tctgcaaaga cactatttcc atataaggtc acattcacag ctactggggt taggacttca

16501 acctagaggg cctgacttct ggcccaacac atcatggccc atcccagcat gccccatccc

16561 cttcctgggt gccccaggca gatcacagga gggcctgact gctgggcttt gggctgacat

16621 tgggatcatc tgcctagtta gggctgtgac cagactgaga taggaggtgg gacctgactc

16681 ctgaggcagg gcttgaactc tggaccagat tacagactag ctgaaacagg caaaagcacc

16741 cctccataag acacacccac tggtgccaag tgagtttgcc gttctcatgg taacagctgg

16801 aaattactgc ccctttccat ggcaatgacc tgaaagttac cacccctttt ctagaaattt

16861 ctaaataacc tcctccttaa tttgtatata gttacaagtg ggtataaata tgtgtgcaga

16921 actgcctctg agctgctact ctgggctgac tgcctatggg gcatccctgc tccataagga

16981 gcagtacctc tgctgccac.t gtgcacagct gcttaaataa aagttgctct ctaataccac

17041 cgactcgccc ttgaattctt tcctgggtga age

(2) INFORMATION FOR SEQ ID NO:2566: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19802 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2566: 1 atatatatat gcataatagt ctctgtgtaa cagtaagtgg atgcagtaac tggtgtgagg

61 gcaacttgga gagtgtgctt ggaggcacag agatgctcag ggctgcctgg actgcctcca

121 tgatggtggc ctgctctgta ttaggtgagt gttcaggaaa ggtgagggca gggcagccca

181 cagcttcaca gtggcccagg gaagcagggc aggcaggcta tgaggcctag taggcatctg

241 ggccagactt tgacactgag gccatggaat gggtggggct ctgagaacag acccaagtga

301 tcatgggctg aaggctatgt ccacagatcc aaggcgggat aggctgtact gggcagtgat

361 gtcagccagg ctccccagcg ggactggggg tgtcaggggc agctctgtcc caggtggcag

421 acactggttt cccctcctgc tctcacaacc ggcctgttac caggtgttgt ctgagctgtg

481 gtgaggcttc cctggtgaca ttcaggagca gggagcctgc gagtaagggt gtatgcatct

541 gccctgactg cctggccctg tggtcaagga tgggggaagg cagctctgcc tgcagctcca

601 ccccatttat aaagcactgt ggtgccttct gctgggacat gtgctgagtg gtgcctcgca

661 ggcactgccc tcgggaagtt cacaggctta tgtggaagct ggtgggaatg ggccaagaag EPI-109 737

721 agaggtgtca ggagccaggt attgggcagg tcccaggtct ctgagcctca gtttcttcat

781 ctgtaggagg gtggtgaccc tgccctgctc agcttaccag gtacagatgt aagttttcag

841 tgcagaggaa aagcagagaa cttcccctca gatggccata cccccttgtc gctgtaccca

901 actctccggt cctactttgt agctctcagg tgtcacatgt ggatcctgcc ctaccatccc

961 ccttgccctg tctagaaacg aggcctgctg agcttggaac catcccactc cctgctctca

1021 agccgtctgc tcctgggtta gcctgtggct gacctggcct gattctacat agatgtgggt

1081 gtttctccac tgctggggca gcagttgtcc attctggggc ctgggtcagc tctcagctgt

1141 ggccgttgtg cctgtgcttc cccaggtcct ggtggtgact ccaaccctgc cctcacatat

1201 cccaagagca ggctgactgc cttccccatt cccacctttc cagtaactgc tgcaagaacg

1261 gacagacact gctgcagaga acttgccacg gtgtttcatg ctgtggctgg tggttccagg

1321 ctgcacgctc cattctagga aagggtgagg cttcctgatc atcagtctta acaggggact

1381 gtcctatggg tacctgtata cgctgccggg agtggggcag agtggggtta gagtagtgcc

1441 tgctgcccat tggggttgtg cgggttcctt aagggctgta gtctgtgtgc gtgtctggtt

1501 ttttcctcct ccttatcagt aatcagtctt gtataaccag gctggccctg cttcctgcct

1561 aggggctatc ggtgtaccat ctggagttgc aaatggggtg atagggcgtc agcggccttc

1621 ccacacccaa gcacttcctg acacccagcc cctcatctct agccaacctc tggctcccct

1681 agggatcctg gggctcaggc ctcacgctcc agcatccggg ggctttgccc ttctggtgtt

1741 gctcttcttt gcaggtgcct tggaacaggg gtgcaacaga gttcagaaag tgccatctgt 1801 tgcatggata ccctgctgcc accctcgtcc acctttctgg ggcagaacag ttggatgggt

1861 ctttatttaa gaggacaaaa gggagagaga atgcatagag gctgggtctg gtggctcacg 1921 cctgtaatcc caacactttg ggaggccaag gcaggtggat cccttgaggt caggaggtca 1981 agactagcct ggccaacatg gtgaaacccc gtctctacta aaaatacaaa aaaaaaaaaa 2041 ttagctgggc atggcgggag atgcctgtaa tcccagctac tcgggaggct gaggcaggat 2101 aatcacttga acccaggagg cggaggttgc agtgagccaa gatcacacca ctgcactcta 2161 gcctgggtga cagagggaga ctgtctcaaa aaaaaaaatt tgcttagaat ttgtctgtgt 2221 gaccctgggc aagtcatttc ccctccttgg gactcagttc cttgcctgtg aacggggaca 2281 gtgcttctcc cttacagagc tgttgtgaga attaaagtag aaaatgtacc tatggtggtt 2341 gttggtagtg accagttccc ccaaccctga ctcccctgca ggatggggcc tgggcccggg 2401 aatgggggat gggctggcag aggatgactg tcccagagag gagtcttctc ggcagatgtg 2461 gagacctagc tgagtcagag gccaggatct aagtttgagg gtgttcctta caccctgcag 2521 ccatgagtct ttggctgagt caaatggcct ttctgagctc agttccttat cagtaaagcc 2581 tggacagtgg tccaggacgc tggacactgt gtgagtgtta ggacacagga cactgtgtga 2641 gtgcaggtgg ggacccatgg agcactctgc tggggagcaa ttcatgggga gcacccctcc 2701 agagagggat gatttgcaca gggccctcag cccagtccct tgcaggctgg accttggaga 2761 gtgaggccct gaggcgagac atgggcacct ggctcctggc ctgcatctgc

1 ggatccatgc ccagaattat tcacgaaatt cacttaaaat agcatatatg cttgaaccca

61 ggagtctgag gctgcagcga gctatgatca tgtcactgca ctccagccca gcctgggcga

121 cagagcaaga ctctgtgtct aaagaaatga aaataaaaat aaataaaata gcatatacag

181 gcaacaatcc aaatgttcat tgcagaaatt atgattatta ttgtttttct tttagaggca

241 gggtgtcact ctgttgccca gactaatctt gacctcctgt gatcctcaag agatcctccg

301 gtctctgctt cccaaagttc ttggattaca ggtgtgaggc actgggccta gacattgcag

361 ggattattaa accatggtgc atactaccat taaaggtatg aggtaggttt tatatgctga

421 cctagaaaga tggtgcaaca ccatagggga acaagaaggc tgcaaagtgg cagcacagca

481 ggagtcttta agaaataggt atttgtttca gcttaagaag tgtctggctg ggcgtggtgg

541 ctcacacctg taatcccagc acttagggag gcttaggtgg gcggatcact tgaggttagg

601 agttcaagac cagcccagtc aacaccggtg aaaccccatc tctactaaaa atacaaagaa

661 attagctggg cttggtggca ggtggctgta atcccagcta ctcaggagct gaggcaggag

721 aatcatctga acccgggagg ccgaggttgc agtgagccta gatcgcacca ctgcactcca

781 gcctgggtga cagagtaaga ctcggtcaaa aaaaaaaaaa aaaaagaccg ggtgcgaggt

841 ctctcgcctg taatcccagc actttgggag gcctaggcag gaggatcaca aggtcaggag

901 atcgagacca tcctggccaa catggtgaaa ccccatctct actaaaatac aaaaattagc

961 cgggtgtgat ggcacacgcc tgtagtccca gctactcagg aggctgaggc aggggaatcg

1021 cttgaaacca ggaggtggag gctgcagtga gccgagatca cgccactgca ctccagcctg

1081 gcgacagagc aagactccat ctcaaaaaag aaaagaaaac aaacaaacaa acaaaatccc

1141 caaaaagcaa aagtgtctgc atggacttgt gcctaactac tcacagtggc tacttcttgg

1201 gggaggtgaa aggggaccct gttaaagaat ttttcttctg tattgttttt cttcaactga

1261 gtctgcatta attttatatt taatactctc cccacccctg atgctcacag gttgctttag

1321 ctggtggaag gagaacctgc acctctggtt ttggcaaagt gtagaagggg acaagggcac

1381 tgctctgcac ctgcacaggt tcttgcctcc tggggtcagt ttaatgaatc tcagtggtgt

1441 ttcttgggaa gaacacagtg gacactcact tgccagtcag tagacaaatc actgaagtcc

1501 atgtctggca gttctcaatg tcatggggac tgtaaggttg tcatgtctca cagttccctg

1561 acttagaaga ttagtggtga cagacacttc tcagctctgc tcgggagagc agctctgtaa

1621 tgcgcttgtg gtttcagatg tgggcggcct gtgtgaacct gtcgtgcaaa gctcacgtca

1681 ccaactgctg cagttatctc ctgaatcagg ctgagggtct ttgctgtgca cccagagata

1741 gttgggtgac aaatcacctc caggttgggg atgcctcaga cttgtgatgg gactgggcag

1801 atgcatctgg gaaggtgagt ctgtgctttg ggcttcccaa cctctcaagt cagcatgaaa

1861 ttcagaaggc agagagggac atgtggccct ccaactcggg gcccagggag ccactgtggc

1921 atttgagagc gccaccctag ctttacctcc tctggtgtcc tggccttgtg tatctcttag EPI-109 738

1981 agatggcaaa atttgcagcc ctgacctcaa ggattacaaa ctaatttcca gtcctgtagg 2041 ggtcatgggt tctgctgtgg ccagtgtggc actgagtttg tcaggcagaa tttctaatta 2101 tggaaggaac tctgcttcct cagtgattga actgaccttt gtgggggtgc ctttgtgggg 2161 tgagaatggg catacttggg cctcagttgt gatggccatg gggtggagct gaggtctagg 2221 cccagggctg ggaaagcttc taccaacccc gaggcatttg ggtgttttag ggcagaagag 2281 gagccaggag gatgggtatg ccccactgga gctgtgtgtg gggcagcagg tgagggtggg 2341 attccagagg gagggtcaac ccagccaagc agaggaaggg gaggagaggg tttgttttgg 2401 aaagaacatc accctctcag tttcctgggg tctggatagc ctgttcttgt gatgagctgg 2461 aggatgtggg ccctgcttgg atcctcctct cccctccctg cccccatttt ctcttcctgt 2521 gatttatgct gttctgggct caccctcttc ccagagctct cacgctacag ctgacaggca 2581 gggcaggcgt tttaattatt attaattttt ttttgagaca gagtttgaga cagtatcaag 2641 agtgggtatc ctctcagcgt gtcttcaagt agcatcccag agccccgctc ctgggtaccc 2701 acaacatgaa caccgtccag aagcaagggc agcctctgca ggtggggcgg gggttggaaa 2761 acatttatca aacggttgag ttgggtgcag gggatgcaac atgatcaaac agggtcttgc 2821 ctccaggagc ctcatgtagg gacaacgcac agtgatgacc ttcaactgca gtggggcagc 2881 aaggctgtgg gaggggtgtt ttgggcagag caggcgacgt gggtacctct tcaccaagac 2941 agcaggaaga gcacggacat cattttcccg tctcacctcc agactcccag gggactgtgc 3001 caatatcctc actggagccc tgcccatggc cactgctcaa cccttgggcc ctgtcagttc 3061 agggctgtgc agaaggagag ttgcctgtgc tcaggctcag gggttccgtc cagctaagga 3121 ggcctactag gggactgggg aaaggcctca tgaaggacca ggcctgtgat ggggagggaa 3181 gatggcagag gggacagtgg gaagcagagc agcaggggtc tcctccacgc ctctctgtac 3241 ttctcccacc cacccttgcc tgctcccctc tgccctgggt atgtgccctt gtccacccaa 3301 cacctctgca gtgccaagtc cagccctgac ttcttcctga gctgtggccc agcgttccca 3361 caggcattta cctcacggat gcagcactgc ccctcatcct cttctctgaa agtgtgtggg 3421 aaatgcttct tggtgccatc tctctcccac cctgccttcc ctgcaccttc tctatgaggt 3481 gtctgttgtc tctgtacttg cctccagctg gcctttcaga ccccatccct ccctgcctcc 3541 tgcccatccc tacccctgtc agcaccttac atactctgtg cccaacagca ttggggattc 3601 ccactgtgct gaaggaagtc ctcatgtggt ccagagaggg agctggcccc tgctcccatt 3661 tccagcacca ttttctggca caggctccat gtccccaggc tccagctgct tctggggtac 3721 caaggtctgc atttcttcct cttcccccag cagacagaag accttgctgg acaggtgtcc 3781 acttcaatag taacttctga ggctgccagc ctcctgaatg gtccagaaga accagaccct 3841 tccccgcccc cattaaaaaa gacaaaatat ggccaggcat gttggctcat gcctgacatc 3901 ccagcacttt gggaggccaa agcaggtgaa tcacttgagg ccaggagtac gagaccagcc 3961 tgacaaacat ggtgaaaccc tgtgtctact aaaaatacaa aaattagcca ggcgtggtga 4021 ctcatgcttg taaatgcttg taatcccagc tacttgggag gctgaagcag gaggatcact 4081 tgaactcggg aggcagaggt tgcagtgagc cgagatcacg ccactgtgtt ccagcctgag 4141 cgacagagcg acactccgtc taaaaaaaaa aaatatatat atatatacac acatatatat 4201 atgcataata gtctctgtgt aacagtaagt ggatgcagta actggtgtga gggcaacttg 4261 gagagtgtgc ttggaggcac agagatgctc agggctgcct ggactgcctc catgatggtg 4321 gcctgctctg tattaggtga gtgttcagga aaggtgaggg cagggcagcc cacagcttca 4381 cagtggccca gggaagcagg gcaggcaggc tatgaggcct agtaggcatc tgggccagac 4441 tttgacactg aggccatgga atgggtgggg ctctgagaac agaccaaagt gatcatgggc 4501 tgaaggctat gtccacagat ccaaggcggg ataggctgtg ctgggcagtg atgtcagcca 4561 ggctccccag cgggactggg ggtgtcaggg gcagctctgt cccaggtggc agacactggt 4621 ttcccctcct gctctcacaa ccggcctgtt accaggtgtt gtctgagctg tggtgaggct 4681 tccctggtga cattcaggag cagggagcct gtgagtaagg gtgtatgcat ctgccctgac 4741 tgcctggccc tgtggtcaag gatgggggaa ggcagctctg cctgcagctc caccccattt 4801 ataaagcact gtggtgcctt ctgctggggc atgtgctgag tggtgcctcg caggcactgc 4861 cctcgggaag ttcacaggct tatgtggaag ctggtgggaa tgggccaaga agagaggtgt 4921 caggagccag gtattgggca ggtcccaggt ctctgagcct cagtttcttc atctgtagga 4981 gggtggtgac cctgccctgc tcagcttacc aggtacagat gtaagttttc agtgcagagg 5041 aaaagcagag aagttcccct cagatggcca tacccccttg tcgctgtacc caactctccg 5101 gtcctacttt gtagctctca ggtgtcacat gtggatcctg ccctaccatc ccccttccct 5161 gtctagaaac gaggcctgct gagcttggag ccatcccact ccctgctctc aagccgtctg 5221 ctcctgggtt agcctgtggc tggcctggcc tgattctaca tagatgtggg tgtttctcca 5281 ctgctggggc agcagttgtc cattctgggg cctgggtcag ctctcagctg tggccgttgt 5341 gcctgtgctt ccccaggtcc tggtggtgac tccaaccctg ccctcacata tcccaagagc 5401 aggctgactg ccttccccat tcccaccttt ccagtaactg ctgcaagaac ggacagacac 5461 tgctgcagag aacttgccac ggtgtttcat gctgtggctg gtggttccag gctgcacgct 5521 ccattctagg aaagggtgag gcttcctgat catcagtctt aacaggggac tgtcctatgg 5581 gtacctgtat acgctgccgg gagtggggca gagtggggtt agagtagtgc ctgctgccca 5641 ttggggttgt gcgggttcct taagggctgt agtctgtgtg cgtgtctggt tttttcctcc 5701 tccttatcag taatcagtct tgtataacca ggctggccct gcttcctgcc taggggctat 5761 cggtgtacca tctggagttg caaatggggt gatagggcgt cagcggcctt cccacaccca 5821 agcacttcct gacacccagc ccctcatctc tagccaacct ctggctcccc tagggatcct 5881 ggggctcagg cctcacgctc cagcatccgg gggctttgcc ttctggtgtt gctcttcttt 5941 gcaggtgcct tggaacaggg gtgcaacaga gttcagaaag tgccatctgt tgcatggata 6001 ccctgctgcc accctcgtcc acctttctgg ggcagaacag ttggatgggt ctttatttaa EPI-109 739

6061 gaggacaaaa gggagagaga atgcatagag gctgggtctg gtgtcacgcc tgtaatccca

6121 acactttggg aggccaaggc aggtggatcc cttgaggtca ggaggtcaag actagcctgg

6181 ccaacatggt gaaaccccgt ctctactaaa aatacaaaaa aaaaaaaatt agctgggcat

6241 ggcgggagat gcctgtaatc ccagctactc gggaggctga ggcaggataa tcacttgaac

6301 ccaggaggcg gaggttgcag tgagccaaga tcacaccact gcactctagc ctgggtgaca

6361 gagggagact gtctcaaaaa aaaaaatttg cttagaattt gtctgtgtga ccctgggcaa

6421 gtcatttccc ctccttggga ctcagttcct tgcctgtgaa cggggacagt gcttctccct

6481 tacagagctg ttgtgagaat taaagtagaa aatgtaccta tggtggttgt tggtagtgac

6541 cagttccccc aaccctgact cccctgcagg atggggcctg ggcccgggaa tgggggatgg

6601 gctggcagag gatgactgtc ccagagagga gtcttctcgg cagatgtgga gacctagctg

6661 agtcagaggc caggatctaa gtttgagggt gttccttaca ccctgcagcc atgagtcttt

6721 ggctgagtca aatggccttt ctgagctcag ttccttatca gtaaagcctg gacagtggtc

6781 caggacgctg gacactgtgt gagtgttagg acacaggaca ctgtgtgagt gcaggtgggg

6841 acccatggag cactctgctg gggagcaatt catggggagc acccctccag agagggatga

6901 tttgcacagg gccctcagcc cagtcccttg caggctggac cttggagagt gaggccctga

6961 ggcgagacat gggcacctgg ctcctggcct gcatctgcat ctgcacctgt gtctgcttgg

7021 gagtctctgt cacaggggaa ggacaaggtg agggctgggc actaatgtct gtatgaggtg

7081 ggtggagaac tagggcatgt ttgggggact gggttgtccg atgtcaagcc tctagggaaa

7141 ggtttggccc aaactgtgct ggggcatgtc ctctaggggt cagcctggac ctcagtctct

7201 agtctcccta cttttacctc cctaccttca ttccctggac cgactgtagt ctcccttcct

7261 tcactctctt gacgcctctc cagatctgac ttgcccgtgt accacaggtc agagcccatc

7321 acttcccagg cctcccagtg cttccctgga cagattctgg gatcatttac tggtgactgc

7381 cctgctaggg tgtcagctgt cagatcctcc ccaacccccg agctcagctc tggcctgaag

7441 tacttaccgt gggctcctga tggtcactgt ctccagggcc aaggtctaga accttcacct

7501 gcctcaccaa caacattctc aggatcgatt gccactggtc tgccccagag ctgggacagg

7561 gctccagccc ctggctcctc ttcaccaggt gagcatggag ggccatgccc acctggacag

7621 ggatgagggt gagttcccca ggattgaagc agctatgcca ggacagtgta gcagccccgt

7681 ggtgctgaca aatgcccttt ccagcaacca ggctcctggc ggcacacata agtgcatctt 7741 gcggggcagt gagtgcaccg tcgtgctgcc acctgaggca gtgctcgtgc catctgacaa 7801 tttcaccatc actttccacc actgcatgtc tgggagggag caggtcagcc tggtggaccc 7861 ggagtacctg ccccggagac acggtgagca gcagctatag gtctggggcg gggccgcttg 7921 gcaagaacat cctggctgct tgggggtttg gagcagggcc ttgcagcctg tgagtggccc 7981 agtgagtgtt ctcagtccca gccgagtgag atccagggct gggggcaggc ttggcccttg 8041 ggaggggagg gcccatatgg ttactgcagg ggcagggttt tggcaggaaa taaacatgca 8101 cggctgctag ttggggcagg ggctggcact tgagtcatgt gaaatgcact tcagtcatac 8161 caggaaggac tccaataaga tgctgggaaa agcttccagc agcagactgt gaaggaaagg 8221 gaaagcaaga tttagaaacc acctagtcta ggtgcagagg ccagaggaag tcattgctgt 8281 cctgtcccgc ctggggcttt tgtggaccag tctcccagtg aggtgcctgg tctgagaggg 8341 ccttgaccat tccccttggg agtctttcag accccagtct tgtgtgttct gactgacaca 8401 cccagaccca tggggcttca gcctcacatg gattcactct gttccagtta agctggaccc 8461 gccctctgac ttgcagagca acatcagttc tggccactgc atcctgacct ggagcatcag 8521 tcctgccttg gagccaatga ccacacttct cagctatgag ctggccttca agaagcagga 8581 agaggcctgg gaggtaacac tttggctggc tttccctggg ggcctctctc ctgggaacag

8641 cagtccaggg tagactcccc actctacata gggagatgtc aacttgtagt gatgagaagg 8701 gaggaactag agcggggtgt gtgtgcacac acacatgctg gcatgcagat gtgtatgctt 8761 tatgtgtgtg tatgggagta gggtgagtgc gcctgtgtct ctgtgtgtgc acataagtgt 8821 ggtgagtgtg catgtatgtg tttatgtgta cacatatgta actgtgcaca ctcatgtttg 8881 tgtgcccatg tttgtgtgtt tatatgtaag tgtacatatg tgtgtgcctg tgccttgcat 8941 ttgtgtgagt gtgcacatgg gcatgcctat gtgtatgagt gtgtatgtga gtgtggtgag 9001 ttgcttctgt gcacacactt ttgtttatga gtgtgcatgc aagtgtgatg agtgtgaaag 9061 tgttcctgta gacatgtttg cctgtgtgtg catatgtgta tttgtgggca aacgcagctg 9121 tgtctgtgag tgtgagtgtg ccttctgtgt gtgtgtgtgc acgtgaatgt ggtgagtgtg 9181 tctgtgtgtt aacacaagtg tgttcaagag tgtgttatat gagcatataa tgcatgtgtg 9241 tattctcgag ggctgaggga cccagcccca ccttcaccac ctgctaactg tccccacccc 9301 cacagcaggc ccagcacagg gatcacattg tcggggtgac ctggcttata cttgaagcct 9361 ttgagctgga ccctggcttt atccatgagg ccaggctgcg tgtccagatg gccacactgg 9421 aggatgatgt ggtagaggag gagcgttata caggccagtg gagtgagtgg agccagcctg 9481 tgtgcttcca ggctccccag agacaaggtg ggcactgctg tggctgctgc acttccagcg 9541 gagtctgggc tgggcgtctt ctcccctgtt cacctcagcc ctgcaccctt tcaccctcct 9601 gtaagcccct ccccgaggca gccatgcctc agttgacccc cttcctctga aggtctgagg 9661 tctgtaggga ggacagaaac acctgccaac tctggggctt cctgggaacc tgtagttagt 9721 ggctgctgtt aggagtgagg gtggcagggc tgcacaccag ggctgggctc ctgcctggag 9781 gctggacatg acctcagtgt ccttaatggg ggctggactg acccttgcgc actgcagtgc 9841 tgagatggcc cagggacttt atgacccacc ttgtggcaga tgggaagagt gaggcccagg 9901 agtgtggttc acacaaggtc cttcagcagg tgacacaaac ctccaaggcc catcacaagg 9961 tccttcagca ggtgacacaa aggtggaagg cccatcacaa accttccact ttggcccagg

10021 gcactaaagg gcgcaccttt gccaggtggg tttgggggga gcctcctggc actgaggctg 10081 ctcacagccc tgggcccttc ctgtccacag gccctctgat cccaccctgg gggtggccag EPI-109 740

10141 gcaacaccct tgttgctgtg tccatctttc tcctgctgac tggcccgacc tacctcctgt 10201 tcaagctgtc gcccaggtag gtggctgatg tgtgcgtgtg tgtacatgtg tgagcgggca 10261 agagtgtgca tgttagtgta tgtgtgcaga tgtgtgactg tgtgcatgtg tgagtgtgtg 10321 gtgggtgggc catcaagggc cgcccttgtc tggttcctcc cctcccctct ccactgcctg 10381 gtcctggacg gggtgggctt ttcgagtctc caccctggtc cagaagaggg ttctcaagtt 10441 gccaggggag agcagggaag gggggtctga ggcagaggct gaagataagg gcagcttggt 10501 cccgaccaga cccagagtca ccgagatcaa gagccggagg tcctagtctc ctgcctctgg 10561 aggagcttgg tttgttcatt tgttcacatg ttctacgaaa ggacagttgg ggcatctggt 10621 gtgctcagga ccctgttctc agaacaagat ggacaagggc cctccttaaa taaaccgtca 10681 cgcctcatgc accacatgtc aggttacaag acagggtgca ggggccatgt caggccgcag 10741 atgtgaggaa gagggtgtgg ggagaggggt gttgggtggg gctaagtggg agggtgcttc 10801 gcttctcctt ggagcaaagg aaagtgtaaa actgtgtgac acaacctagt ttatgttttg 10861 aggaatagat tgctgggaca aggggacatg ggggacctgc tggaggccaa tgggggccag 10921 tgaggtgccc acagggagac gatttgcatg agccagtgaa agaagtggag atagagaaaa 10981 gtggagagaa ttgcagggtc tcatgagggg aaatagaagg gacatgtggg tggatgagat 11041 atgagtggtg acccctgagg tggggaaatg ggggacagcc ttgcagggag gttggtgaag 11101 tctatttgga cctgttgggt tggagcccca ggtgacatcc ttgtgggagg gtcagtggat 11161 ccttggcagc aagtctggtg ctcagggaga cactgggtgg ggtgggagcc acagaccttc 11221 tgctgatggc aaagacaggg ttcctggagg tgctggctcc ctctgtgatc tgaggaccca 11281 gctagtaact ccccgttctg aacccgccat cgcagctcac gctgtaaagg acgcgcgcct 11341 cagtataaat cagttctatg cggccgttag gcaaggaggc ccagttgggt cctgccctga 11401 gagtgggttg gaatgtgatg agatgggaga gaggcagtgg cagggacgag gtgggcggac 11461 ctcctgctga tggaaggaag ctcagcctct gcagtgacct caggccacct gggtcgccat 11521 aggcctctga ctggcctctc ttggcctcag ggtgaagaga atcttctacc agaacgtgcc 11581 ctctccagcg atgttcttcc agcccctcta cagtgtacac aatgggaact tccaggtgtg 11641 tgcagagacc acagaaggac atggggggca ggggttgccc agagctctgg cctgcccaag 11701 atgttggctt tcatgagggt tggcggccag tatgggaggc ttgtcagtgc ttggagcctt 11761 ttttgtatat tcagtgaatt tcaatttata cgcgtatctc aaatggggaa aaattagctt 11821 tattttccat tgctgatttc tttttgttct caggtctcta gttccattgt tgattgaaaa 11881 aatgtaaatt tctcataact tatctctgtc ccctctggtt tgcagctttc tgcacccacc 11941 atgtgcctca cctcctcctt ctgcgaaggt gtctgtcctg tggccatggg gaagggtctg 12001 tggtgtgtgt gctgcccttg gggctctcac tgcctctggg ctcctgctct gcctggtccc 12061 ctggtctccc cggatcacat gatggcacca cagctgagga gtgggctctg cacttccccc 12121 ccttccaccc atgttgggct cctacagccc aggcaccagt gagcaacttg ggggttgcat 12181 cagcccctcc cctccctgct gggctgttgg ttcatgcccc ctgggtggga ggagggggag 12241 agggagagct ccagtgagtg gtctctggtt tttcccctca gactcctcac tttgggcaaa 12301 ggacaagagg cagtgagggc ccctccctgg ggtctgggcc aagctgacca ctcttctcca 12361 gaatcttccc tccctgtccc cttcacactg tggctccagc ttactatgca gaaaaatcct 12421 tttctctctc aatgaggagc gtagttttca agatttttgt ccaaaaatat aatttgaacc 12481 atgaaccggg catctggctc ttggcagagt ctccctcttt ccccaaggtg gtagatgtga 12541 ctgtcaggag cctgggcagc tgacgacaag gctgagcagg tcagattgtg actgtcccct 12601 ggactgtcat cctgttgcgg gcaccagctg ttccctagag aactaggaca cctgccacgg 12661 gttatttaga ctgcgggtga ggatctggtg ccataggttg gtctccaggg agcactgcag 12721 tgatggaggg tgttgtgtgt gtgatgcatg ggatggaggc tcctggtccc accaagggaa 12781 cagcttcctt ttggaggcgg gggcctcctg tggccccaca gaaggatcca ggtctgctgg 12841 ccatagccga gtgctttgaa agtcaccagt cctgacagcg attcgtgtgt gtgtctgtgt 12901 gtgtgtgtgt gtgtttatgt gtctgtgtgt gttcgtgtgt gtgtctgtgt gtgtgtttgt 12961 gtgtgtatgt ctgtgtgtgt gtgtttatgt gtgtgtgtct gtatgtgttt aagtctgtgt 13021 gtgtttgtgt gtgtgtgtct ctgtgtgtgt gtctgtatct gtgtgtgttt gtgtctgtgt 13081 gtgtttgtgt gtgtgtctgt gtgtgtctgt gtgtgtgtct gtgtgtgtgt ttatgtgtct 13141 gtgtatgttt gtgtgtgtgt ttgtgtgtgt gtgtttgtgt ttatgtgtgt atgtctgtgt 13201 gtgtctgtgt gtctgtgtgt gtatgtgtct gtgtgtgttt atgtgtctgt gtgtgttcgt 13261 gtgtgtgtct gtgtgtgtgt gtttgtgtgt gtatgtctgt gtgtgtgtgt gtttatgtgt 13321 gtgtgtctgt gtgtgtttat gtctgtgtgt gtttgtgtgt gtgtgtctcg tgtgtgtgtg 13381 tctgtgtgta tctgtgtgtg tttgtgtgtg tgtgtgtctc tgtgtgtgtg tgtgtttgtg 13441 tatgtttgtg tgtgtgtgtg tgtgtgttgg gaatgcccag tctctgcagc tgctgaaagg 13501 ccctgaggca catgctgtca ggagctggct ctgtcctggg cagatatcac catctgtacc 13561 tcggttcagg ctgccgtggg caccaggccc tgtgctgggg gagtgctgag gagcctgaag 13621 ggactcaggg tcccgtgatg aggctgggct ggcacatgga ggaaagacag aatgtccaag 13681 acacaggcgc tgcttggcct ctgggtgtgg acctcaggag ggcttcctgg aggaggaggg 13741 atgctgggct tgccagaaag gaggcagctg ctcccaggat gagttctgaa catgctacct 13801 gagcccttcc ctcctcccgt gctctgttcc agacttggat gggggcccac ggggccggtg 13861 tgctgttgag ccaggactgt gctggcaccc cacagggagc cttggagccc tgcgtccagg 13921 aggccactgc actgctcact tgtggcccag cgcgtccttg gaaatctgtg gccctggagg 13981 aggaacagga gggccctggg accaggctcc cggggaacct gagctcagag gatgtgctgc 14041 cagcagggtg tacggagtgg agggtacaga cgcttgccta tctgccacag gaggactggg 14101 cccccacgtc cctgactagg ccggctcccc cagactcaga gggcagcagg agcagcagca 14161 gcagcagcag cagcaacaac aacaactact gtgccttggg ctgctatggg ggatggcacc EPI-109 741

14221 tctcagccct cccaggaaac acacagagct ctgggcccat cccagccctg gcctgtggcc 14281 tttcttgtga ccatcagggc ctggagaccc agcaaggagt tgcctgggtg ctggctggtc 14341 actgccagag gcctgggctg catgaggacc tccagggcat gttgctccct tctgtcctca 14401 gcaaggctcg gtcctggaca ttctaggtcc ctgactcgcc agatgcatca tgtccatttt 14461 gggaaaatgg actgaagttt ctggagccct tgtctgagac tgaacctcct gagaaggggc 14521 ccctagcagc ggtcagaggt cctgtctgga tggaggctgg aggctccccc ctcaacccct 14581 ctgctcagtg cctgtgggga gcagcctcta ccctcagcat cctggccaca agttcttcct 14641 tccattgtcc cttttcttta tccctgacct ctctgagaag tggggtgtgg tctctcagct 14701 gttctgccct cataccctta aagggccagc ctgggcccag tggacacagg taaggcacca 14761 tgaccacctg gtgtgacctc tctgtgcctt actgaggcac ctttctagag attaaaaggg 14821 gcttgatggc tgttcccaaa gtgttgatgg ctgggagaag gggccagagg aggagtgagg 14881 ggtggggttt gtccagccct gggctttccg ggctctagag atagcatggt gtaggctcaa 14941 tgacagttct ggggacagca agttggaggt tcaggggcag cttcaggaca gcaggatgga 15001 ggctcaggga caattcctgg gaggccagtg ccctcgttcc tccttgtcct catcctcccc 15061 cttgctccag gaaactgaga gctgagcctg gagcttccag acagtcagtg ctgggggtga 15121 ccatccagca gtgatggtgg cctgtgaagg gtcctgcttc tgtcctcagc ctctcatggg 15181 gtgggcttgt ggaggagctg tggtctggag agagtggcag ttggagcaga acgtgcctgc 15241 gtttgtttcc tagggctgtc gtaacaaagt gccacaaaat ggttagctta gaaccacaga 15301 gatttgttgt ctcacaattc tgaagtccag aagttggaaa taaagatgtt ggcagtgttc 15361 ccaaccacat gttcttgggc tcccatgaaa cagaagttga tattaggcca aggaagcttc 15421 ccagacaaga ctttattaag tcttatgccc cgaaagtttg ggcagaagag agacggtgca 15481 ggaggaagaa ttcttggctg actccccaag gggaatgcat tgtggtgtct taaggagggt 15541 gacatacata atttatgagc tacatgagtg tcattgcaca tatggggtgg agcgaagggt 15601 gctcagacgc atgctaacac atacgttgca tgatcagaaa atggcagata agcccctccc 15661 tgggtgagga ctttagtatt atcataagac cagggtcatt ctcctggcct tgtgcacaag 15721 caggtgatgg agtcaactcc cgtcagtaag acttatggcg ggatgctgct tatcttagtt 15781 tatttcagac agttggcaag gtctggccag cgagtatggc acctggaggg tggtgctgca 15841 aggtctagtg gtcagcgggc acgtatggaa caatacgtta gtgggggtgg gccgagtccc 15901 atttatactc tctcagcagg gccatgctcc ctctgaaggc actagggaag gattagtttc 15961 aggcctctct tcagcttctg ttagtttctt ggcttgtgac accaaagctg taatctttct 16021 tttgttttgt ttttgtgacg gagttttgct cttgttgccc aggctggagt gcaatggcac 16081 aatctcggct cactgcaacc tcctcctccc aggtttaagc aattcttctg cctcagcctt 16141 tggagtagct gtgattacaa ggcacctgct accacgcctg gctagttttt gtatttttag 16201 tagagacggt gtttcgctat gttggccagg ctggtctcaa actcctgata tcaagtgatc 16261 cgtctgtctc tgcctcccaa agtgttggga ttacaggcat gagccaccgt gcctggccaa 16321 agttccagtc tttacaggga tttttccttg tgtgcatttc tgtgtccaaa tttccccttt 16381 ttaaaatcac aataatagtg aattaaggct ggccctaacg atttaatctt aacttgatca 16441 tctgcaaaga cactatttcc atataaggtc acattcacag ctactggggt taggacttca 16501 acctagaggg cctgacttct ggcccaacac atcatggccc atcccagcat gccccatccc 16561 cttcctgggt gccccaggca gatcacagga gggcctgact gctgggcttt gggctgacat 16621 tgggatcatc tgcctagtta gggctgtgac cagactgaga taggaggtgg gacctgactc 16681 ctgaggcagg gcttgaactc tggaccagat tacagactag ctgaaacagg caaaagcacc 16741 cctccataag acacacccac tggtgccaag tgagtttgcc gttctcatgg taacagctgg 16801 aaattactgc ccctttccat ggcaatgacc tgaaagttac cacccctttt ctagaaattt 16861 ctaaataacc tcctccttaa tttgtatata gttacaagtg ggtataaata tgtgtgcaga 16921 actgcctctg agctgctact ctgggctgac tgcctatggg gcatccctgc tccataagga 16981 gcagtacctc tgctgccact gtgcacagct gcttaaataa aagttgctct ctaataccac 17041 cgactcgccc ttgaattctt tcctgggtga age

(2) INFORMATION FOR SEQ ID NO: 2567: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2041 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2567:

1 aattcagaac tcctcagccc cccaagaaaa aaatatcccc gtggaaattc ctttttaatg

61 accgaggcgg gggaaatatg cgtctctgga tggccagtga ctcgcagccc ccttccccga

121 taggaagggc ctgcgcgtcc ggggaccctt cgcttcccct tctgctgcgc gacctccctg

181 gcccctcgga gatctccatg gcgacgccgc gcgcgcccca caacaggaaa gccttaggcg

241 gcgcggcttg gtgctcggag acttaagagt acccagcccc tcgacgtggt ggatgtcgag

301 tcttggggtc acacgcacag gcggtggcca agcaaacacc cgctcatatt tagtgcatga

361 gcctgggttc gagttgccgg agcctcgcgc gtagggcagg ggttcgagcg ccccttctcc

421 ctgcctcgcc tctgcgcctg ggggctgctg cctcagtttc ccagcgacag gcagggattt

481 cgagcgtccc cctcccctcc ctcgtcaaga tccaagctag ctgcctcagt ttccccgcgg

541 agcctgggac gccagcggag gggctcggcg cgtagggatc acgcagcttc cttccttttt

601 ctgggagctg taaagacgcc tccgccaacg ccgaaagggg aagcgaggag gccgccgggg

661 tgagtgccct cgggtgtaga gagaggacgc cgatttcccc ggacgtggtg agaccgcgct

721 tcgtcactcc cacggttagc ggtcgccggg aggtgcctgg ctctgctctg gccgcttctc EPI-109 742

781 gagaaatgcc cgtgtca ct aggtgtggac gtgacctagg gggaggggca tccctcagtg

841 gagggagccc ggggaggatt cctgggcccc cacccaggca gggggctcat ccactcgatt

901 aaagaggcct gcgtaagctg gagagggagg acttgagttc ggaccccctc gcagcctgga

961 gtctcagttt accgctttgt gaaatggaca caataacagt ctccactctc cggggaagtt

1021 ggcagtattt aaaagtactt aataaacgcc ttagcgcggt gtagaccgtg attcaagctt

1081 agcctggccg ggaaacggga ggcgtggagg ccgggagcag cccccggggt catcgccctg

1141 ccaccgccgc ccgattgctt tagcttggaa attccggagc tgaagcggcc agcgagggag

1201 gatgaccctc tcggcccggg caccctgtca gtccggaaat aactgcagca tttgttccgg

1261 aggggaaggc gcgaggtttc cgggaaagca gcaccgcccc ttggccccca ggtggctagc

1321 gctataaagg atcacgcgcc ccagtcgacg ctgagctcct ctgctactca gagttgcaac

1381 ctcagcctcg ctatggctcc cagcagcccc cggcccgcgc tgcccgcact cctggtcctg

1441 ctcggggctc tgttcccagg tgagtcgggg tggggattgc cgtcgggcca gttctccgaa

1501 gcccgggagg accggctccc gggtcaggtc atgcatgctt aggtagctgt ttatgggaag

1561 gaggggctag agacagcgat tgaaagcaac agccagtagg ttcgaatcca gaccctgcat

1621 acctccacgt gtggccttgg gctatagatt gcagctttaa aaaagggtag ggggttggag

1681 atggagggga ggggcgggcc tcgttttgtt gcccaggccg gtcttgaact ccgggggtct

1741 agccttacct cctgcctcag cctcccgagt agctgggatg aggtgtgaac cacgccttgc

1801 ttggctagat tgcgtctctt acagtttctc agctgtaaaa cgggaaacgt tatagcggcc

1861 acctggcagg gtatcttggc ccagcgcagc acctggcccc aggactcgat catgatggtt

1921 tgggaacttg gctctgtgcc aacccaacaa ggcttaaggg acccccaccc ccctcaagat

1981 gtatattctg ttcctcatcc tctctgcccc tggggaagtc cagggctgct tctacttggg 2041 gg

(2) INFORMATION FOR SEQ ID NO:2568: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2941 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xι)SEQUENCE DESCRIPTION: SEQ ID NO:2568:

1 gcgccccagt cgacgctgag ctcctctgct actcagagtt gcaacctcag cctcgctatg

61 gctcccagca gcccccggcc cgcgctgccc gcactcctgg tcctgctcgg ggctctgttc

121 ccaggacctg gcaatgccca gacatctgtg tccccctcaa aagtcatcct gccccgggga

181 ggctccgtgc tggtgacatg cagcacctcc tgtgaccagc ccaagttgtt gggcatagag

241 accccgttgc ctaaaaagga gttgctcctg cctgggaaca accggaaggt gtatgaactg

301 agcaatgtgc aagaagatag ccaaccaatg tgctattcaa actgccctga tgggcagtca

361 acagctaaaa ccttcctcac cgtgtactgg actccagaac gggtggaact ggcacccctc

421 ccctcttggc agccagtggg caagaacctt accctacgct gccaggtgga gggtggggca

481 ccccgggcca acctcaccgt ggtgctgctc cgtggggaga aggagctgaa acgggagcca

541 gctgtggggg agcccgctga ggtcacgacc acggtgctgg tgaggagaga tcaccatgga

601 gccaatttct cgtgccgcac tgaactggac ctgcggcccc aagggctgga gctgtttgag

661 aacacctcgg ccccctacca gctccagacc tttgtcctgc cagcgactcc cccacaactt

721 gtcagccccc gggtcctaga ggtggacacg caggggaccg tggtctgttc cctggacggg

781 ctgttcccag tctcggaggc ccaggtccac ctggcactgg gggaccagag gttgaacccc

841 acagtcacct atggcaacga ctccttctcg gccaaggcct cagtcagtgt gaccgcagag

901 gacgagggca cccagcggct gacgtgtgca gtaatactgg ggaaccagag ccaggagaca

961 ctgcagacag tgaccatcta cagctttccg gcgcccaacg tgattctgac gaagccagag

1021 gtctcagaag ggaccgaggt gacagtgaag tgtgaggccc accctagagc caaggtgacg

1081 ctgaatgggg ttccagccca gccactgggc ccgagggccc agctcctgct gaaggccacc

1141 ccagaggaca acgggcgcag cttctcctgc tctgcaaccc tggaggtggc cggccagctt

1201 atacacaaga accagacccg ggagcttcgt gtcctgtatg gcccccgact ggacgagagg

1261 gattgtccgg gaaactggac gtggccagaa aattcccagc agactccaat gtgccaggct

1321 tgggggaacc cattgcccga gctcaagtgt ctaaaggatg gcactttccc actgcccatc

1381 ggggaatcag tgactgtcac tcgagatctt gagggcacct acctctgtcg ggccaggagc

1441 actcaagggg aggtcacccg cgaggtgacc gtgaatgtgc tctccccccg gtatgagatt

1501 gtcatcatca ctgtggtagc agccgcagtc ataatgggca ctgcaggcct cagcacgtac

1561 ctctataacc gccagcggaa gatcaagaaa tacagactac aacaggccca aaaagggacc

1621 cccatgaaac cgaacacaca agccacgcct ccctgaacct atcccgggac agggcctctt

1681 cctcggcctt cccatattgg tggcagtggt gccacactga acagagtgga agacatatgc

1741 catgcagcta cacctaccgg ccctgggacg ccggaggaca gggcattgtc ctcagtcaga

1801 tacaacagca tttggggcca tggtacctgc acacctaaaa cactaggcca cgcatctgat

1861 ctgtagtcac atgactaagc caagaggaag gagcaagact caagacatga ttgatggatg

1921 ttaaagtcta gcctgatgag aggggaagtg gtgggggaga catagcccca ccatgaggac

1981 atacaactgg gaaatactga aacttgctgc ctattgggta tgctgaggcc cacagactta

2041 cagaagaagt ggccctccat agacatgtgt agcatcaaaa cacaaaggcc cacacttcct

2101 gacggatgcc agcttgggca ctgctgtcta ctgaccccaa cccttgatga tatgtattta

2161 ttcatttgtt attttaccag ctatttattg agtgtctttt atgtaggcta aatgaacata

2221 ggtctctggc ctcacggagc tcccagtcca tgtcacattc aaggtcacca ggtacagttg

2281 tacaggttgt acactgcagg agagtgcctg gcaaaaagat caaatggggc tgggacttct EPI-109 743

2341 cattggccaa cctgcctttc cccagaagga gtgatttttc tatcggcaca aaagcactat

2401 atggactggt aatggttcac aggttcagag attacccagt gaggccttat tcctcccttc

2461 cccccaaaac tgacaccttt gttagccacc tccccaccca catacatttc tgccagtgtt

2521 cacaatgaca ctcagcggtc atgtctggac atgagtgccc agggaatatg cccaagctat

2581 gccttgtcct cttgtcctgt ttgcatttca ctgggagctt gcactattgc agctccagtt

2641 tcctgcagtg atcagggtcc tgcaagcagt ggggaagggg gccaaggtat tggaggactc

2701 cctcccagct ttggaagggt catccgcgtg tgtgtgtgtg tgtatgtgta gacaagctct

2761 cgctctgtca cccaggctgg agtgcagtgg tgcaatcatg gttcactgca gtcttgacct

2821 tttgggctca agtgatcctc ccacctcagc ctcctgagta gctgggacca taggctcaca

2881 acaccacacc tggcaaattt gatttttttt ttttttttca gagacggggt ctcgcaacat

2941 tgcccagact tcctttgtgt tagttaataa agctttctca actgcc

(2) INFORMATION FOR SEQ ID NO:2569: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3001 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi)SEQUENCE DESCRIPTION: SEQ ID NO:2569:

1 gctataagga tcacgcgccc cagtcgacgc tgagctcctc tgctactcag agttgcaacc

61 tcagcctcgc tatggctccc agcagccccc ggcccgcgct gcccgcactc ctggtcctgc

121 tcggggctct gttcccagg^'a cctggcaatg cccagacatc tgtgtccccc tcaaaagtca

181 tcctgccccg gggaggctcc gtgctggtga catgcagcac ctcctgtgac cagcccaagt

241 tgttgggcat agagaccccg ttgcctaaaa aggagttgct cctgcctggg aacaaccgga

301 aggtgtatga actgagcaat gtgcaagaag atagccaacc aatgtgctat tcaaactgcc

361 ctgatgggca gtcaacagct aaaaccttcc tcaccgtgta ctggactcca gaacgggtgg

421 aactggcacc cctcccctct tggcagccag tgggcaagaa ccttacccta cgctgccagg

481 tggagggtgg ggcaccccgg gccaacctca ccgtggtgct gctccgtggg gagaaggagc

541 tgaaacggga gccagctgtg ggggagcccg ctgaggtcac gaccacggtg ctggtgagga

601 gagatcacca tggagccaat ttctcgtgcc gcactgaact ggacctgcgg ccccaagggc

661 tggagctgtt tgagaacacc tcggccccct accagctcca gacctttgtc ctgccagcga

721 ctcccccaca acttgtcagc ccccgggtcc tagaggtgga cacgcagggg accgtggtct

781 gttccctgga cgggctgttc ccagtctcgg aggcccaggt ccacctggca ctgggggacc

841 agaggttgaa ccccacagtc acctatggca acgactcctt ctcggccaag gcctcagtca

901 gtgtgaccgc agaggacgag ggcacccagc ggctgacgtg tgcagtaata ctggggaacc

961 agagccagga gacactgcag acagtgacca tctacagctt tccggcgccc aacgtgattc

1021 tgacgaagcc agaggtctca gaagggaccg aggtgacagt gaagtgtgag gcccacccta

1081 gagccaaggt gacgctgaat ggggttccag cccagccact gggcccgagg gcccagctcc

1141 tgctgaaggc caccccagag gacaacgggc gcagcttctc ctgctctgca accctggagg

1201 tggccggcca gcttatacac aagaaccaga cccgggagct tcgtgtcctg tatggccccc

1261 gactggacga gagggattgt ccgggaaact ggacgtggcc agaaaattcc cagcagactc

1321 caatgtgcca ggcttggggg aacccattgc ccgagctcaa gtgtctaaag gatggcactt

1381 tcccactgcc catcggggaa tcagtgactg tcactcgaga tcttgagggc acctacctct

1441 gtcgggccag gagcactcaa ggggaggtca cccgcaaggt gaccgtgaat gtgctctccc

1501 cccggtatga gattgtcatc atcactgtgg tagcagccgc agtcataatg ggcactgcag

1561 gcctcagcac gtacctctat aaccgccagc ggaagatcaa gaaatacaga ctacaacagg

1621 cccaaaaagg gacccccatg aaaccgaaca cacaagccac gcctccctga acctatcccg

1681 ggacagggcc tcttcctcgg ccttcccata ttggtggcag tggtgccaca ctgaacagag

1741 tggaagacat atgccatgca gctacaccta ccggccctgg gacgccggag gacagggcat

1801 tgtcctcagt cagatacaac agcatttggg gccatggtac ctgcacacct aaaacactag

1861 gccacgcatc tgatctgtag tcacatgact aagccaagag gaaggagcaa gactcaagac

1921 atgattgatg gatgttaaag tctagcctga tgagagggga agtggtgggg gagacatagc

1981 cccaccatga ggacatacaa ctgggaaata ctgaaacttg ctgcctattg ggtatgctga

2041 ggccccacag acttacagaa gaagtggccc tccatagaca tgtgtagcat caaaacacaa

2101 aggcccacac ttcctgacgg atgccagctt gggcactgct gtctactgac cccaaccctt

2161 gatgatatgt atttattcat ttgttatttt accagctatt tattgagtgt cttttatgta

2221 ggctaaatga acataggtct ctggcctcac ggagctccca gtccatgtca cattcaaggt

2281 caccaggtac agttgtacag gttgtacact gcaggagagt gcctggcaaa aagatcaaat

2341 ggggctggga cttctcattg gccaacctgc ctttccccag aaggagtgat ttttctatcg

2401 gcacaaaagc actatatgga ctggtaatgg ttcacaggtt cagagattac ccagtgaggc

2461 cttattcctc ccttcccccc aaaactgaca cctttgttag ccacctcccc acccacatac

2521 atttctgcca gtgttcacaa tgacactcag cggtcatgtc tggacatgag tgcccaggga

2581 atatgcccaa gctatgcctt gtcctcttgt cctgtttgca tttcactggg agcttgcact

2641 attgcagctc cagtttcctg cagtgatcag ggtcctgcaa gcagtgggga agggggccaa

2701 ggtattggag gactccctcc cagctttgga agcctcatcc gcgtgtgtgt gtgtgtgtgt

2761 atgtgtagac aagctctcgc tctgtcaccc aggctggagt gcagtggtgc aatcatggtt

2821 cactgcagtc ttgacctttt gggctcaagt gatcctccca cctcagcctc ctgagtagct

2881 gggaccatag gctcacaaca ccacacctgg caaatttgat tttttttttt tttttcagag

2941 acggggtctc gcaacattgc ccagacttcc tttgtgttag ttaataaagc tttctcaact EPI-109 744

3001 gcc

( 2 ) INFORMATION FOR SEQ ID NO : 2570 : ( i ) SEQUENCE CHARACTERISTICS :

(A) LENGTH : 1801 base pairs

(B) TYPE : nucleic acid

(C ) STRANDEDNESS : single

( D) TOPOLOGY : linear

(xi)SEQUENCE DESCRIPTION: SEQ ID NO:2570:

1 ctcagcctcg ctatggctcc cagcagcccc cggcccgcgc tgcccgcact cctggtcctg

61 ctcggggctc tgttcccagg acctggcaat gcccagacat ctgtgtcccc ctcaaaagtc

121 atcctgcccc ggggaggctc cgtgctggtg acatgcagca cctcctgtga ccagcccaag

181 ttgttgggca tagagacccc gttgcctaaa aaggagttgc tcctgcctgg gaacaaccgg

241 aaggtgtatg aactgagcaa tgtgcaagaa gatagccaac caatgtgcta ttcaaactgc

301 cctgatgggc agtcaacagc taaaaccttc ctcaccgtgt actggactcc agaacgggtg

361 gaactggcac ccctcccctc ttggcagcca gtgggcaaga accttaccct acgctgccag

421 gtggagggtg gggcaccccg ggccaacctc accgtggtgc tgctccgtgg ggagaaggag

481 ctgaaacggg agccagctgt gggggagccc gctgaggtca cgaccacggt gctggtgagg

541 agagatcacc atggagccaa tttctcgtgc cgcactgaac tggacctgcg gccccaaggg

601 ctggagctgt ttgagaacac ctcggccccc taccagctcc agacctttgt cctgccagcg

661 actcccccac aacttgtcag cccccgggtc ctagaggtgg acacgcaggg gaccgtggtc

721 tgttccctgg acgggctgtt cccagtctcg gaggcccagg tccacctggc actgggggac

781 cagaggttga accccacagt cacctatggc aacgactcct tctcggccaa ggcctcagtc

841 agtgtgaccg cagaggacga gggcacccag cggctgacgt gtgcagtaat actggggaac

901 cagagccagg agacactgca gacagtgacc atctacagct ttccggcgcc caacgtgatt

961 ctgacgaagc cagaggtctc agaagggacc gaggtgacag tgaagtgtga ggcccaccct

1021 agagccaagg tgacgctgaa tggggttcca gcccagccac tgggcccgag ggcccagctc

1081 ctgctgaagg ccaccccaga ggacaacggg cgcagcttct cctgctctgc aaccctggag

1141 gtggccggcc agcttataca caagaaccag acccgggagc ttcgtgtcct gtatggcccc

1201 cgactggacg agagggattg tccgggaaac tggacgtggc cagaaaattc ccagcagact

1261 ccaatgtgcc aggcttgggg gaacccattg cccgagctca agtgtctaaa ggatggcact

1321 ttcccactgc ccatcgggga atcagtgact gtcactcgag atcttgaggg cacctacctc

1381 tgtcgggcca ggagcactca aggggaggtc acccgcgagg tgaccgtgaa tgtgctctcc

1441 ccccggtatg agattgtcat catcactgtg gtagcagccg cagtcataat gggcactgca

1501 ggcctcagca cgtacctcta taaccgccag cggaagatca agaaatacag actacaacag

1561 gcccaaaaag ggacccccat gaaaccgaac acacaagcca cgcctccctg aacctatccc

1621 gggacagggc ctcttcctcg gccttcccat attggtggca gtggtgccac actgaacaga

1681 gtggaagaca tatgccatgc agctacacct accggccctg ggacgccgga ggacagggca

1741 ttgtcctcag tcagatacaa cagcatttgg ggccatggta cctgcacacc taaaacacta

1801 ggccacgcat ctgatctgta gtcacatgac taagccaaga ggaagg

(2) INFORMATION FOR SEQ ID NO:2571: (i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 9784 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2571:

1 aattcagaac tcctcagccc cccaagaaaa aaatatcccc gtggaaattc ctttttaatg

61 accgaggcgg gggaaatatg cgtctctgga tggccagtga ctcgcagccc ccttccccga

121 taggaagggc ctgcgcgtcc ggggaccctt cgcttcccct tctgctgcgc gacctccctg

181 gcccctcgga gatctccatg gcgacgccgc gcgcgcccca caacaggaaa gccttaggcg

241 gcgcggcttg gtgctcggag acttaagagt acccagcccc tcgacgtggt ggatgtcgag

301 tcttggggtc acacgcacag gcggtggcca agcaaacacc cgctcatatt tagtgcatga

361 gcctgggttc gagttgccgg agcctcgcgc gtagggcagg ggttcgagcg ccccttctcc

421 ctgcctcgcc tctgcgcctg ggggctgctg cctcagtttc ccagcgacag gcagggattt

481 cgagcgtccc cctcccctcc ctcgtcaaga tccaagctag ctgcctcagt ttccccgcgg

541 agcctgggac gccagcggag gggctcggcg cgtagggatc acgcagcttc cttccttttt

601 ctgggagctg taaagacgcc tccgccaacg ccgaaagggg aagcgaggag gccgccgggg

661 tgagtgccct cgggtgtaga gagaggacgc cgatttcccc ggacgtggtg agaccgcgct

721 tcgtcactcc cacggttagc ggtcgccggg aggtgcctgg ctctgctctg gccgcttctc

781 gagaaatgcc cgtgtcagct aggtgtggac gtgacctagg gggaggggca tccctcagtg

841 gagggagccc ggggaggatt cctgggcccc cacccaggca gggggctcat ccactcgatt

901 aaagaggcct gcgtaagctg gagagggagg acttgagttc ggaccccctc gcagcctgga

961 gtctcagttt accgctttgt gaaatggaca caataacagt ctccactctc cggggaagtt

1021 ggcagtattt aaaagtactt aataaacgcc ttagcgcggt gtagaccgtg attcaagctt

1081 agcctggccg ggaaacggga ggcgtggagg ccgggagcag cccccggggt catcgccctg

1141 ccaccgccgc ccgattgctt tagcttggaa attccggagc tgaagcggcc agcgagggag

1201 gatgaccctc tcggcccggg caccctgtca gtccggaaat aactgcagca tttgttccgg EPI-109 745

1261 aggggaaggc gcgaggtttc cgggaaagca gcaccgcccc ttggccccca ggtggctagc 1321 gctataaagg atcacgcgcc ccagtcgacg ctgagctcct ctgctactca gagttgcaac 1381 ctcagcctcg ctatggctcc cagcagcccc cggcccgcgc tgcccgcact cctggtcctg 1441 ctcggggctc tgttcccagg tgagtcgggg tggggattgc cgtcgggcca gttctccgaa 1501 gcccgggagg accggctccc gggtcaggtc atgcatgctt aggtagctgt ttatgggaag 1561 gaggggctag agacagcgat tgaaagcaac agccagtagg ttcgaatcca gaccctgcat 1621 acctccacgt gtggccttgg gctatagatt gcagctttaa aaaagggtag ggggttggag 1681 atggagggga ggggcgggcc tcgttttgtt gcccaggccg gtcttgaact ccgggggtct 1741 agccttacct cctgcctcag cctcccgagt agctgggatg aggtgtgaac cacgccttgc 1801 ttggctagat tgcgtctctt acagtttctc agctgtaaaa cgggaaacgt tatagcggcc 1861 acctggcagg gtatcttggc ccagcgcagc acctggcccc aggactcgat catgatggtt 1921 tgggaacttg gctctgtgcc aacccaacaa ggcttaaggg acccccaccc ccctcaagat 1981 gtatattctg ttcctcatcc tctctgcccc tggggaagtc cagggctgct tctacttggg 2041 gg

1 gcgccccagt cgacgctgag ctcctctgct actcagagtt gcaacctcag cctcgctatg

61 gctcccagca gcccccggcc cgcgctgccc gcactcctgg tcctgctcgg ggctctgttc

121 ccaggacctg gcaatgccca gacatctgtg tccccctcaa aagtcatcct gccccgggga

181 ggctccgtgc tggtgacatg cagcacctcc tgtgaccagc ccaagttgtt gggcatagag

241 accccgttgc ctaaaaagga gttgctcctg cctgggaaca accggaaggt gtatgaactg

301 agcaatgtgc aagaagatag ccaaccaatg tgctattcaa actgccctga tgggcagtca

361 acagctaaaa ccttcctcac cgtgtactgg actccagaac gggtggaact ggcacccctc

421 ccctcttggc agccagtggg caagaacctt accctacgct gccaggtgga gggtggggca

481 ccccgggcca acctcaccgt ggtgctgctc cgtggggaga aggagctgaa acgggagcca

541 gctgtggggg agcccgctga ggtcacgacc acggtgctgg tgaggagaga tcaccatgga

601 gccaatttct cgtgccgcac tgaactggac ctgcggcccc aagggctgga gctgtttgag

661 aacacctcgg ccccctacca gctccagacc tttgtcctgc cagcgactcc cccacaactt

721 gtcagccccc gggtcctaga ggtggacacg caggggaccg tggtctgttc cctggacggg

781 ctgttcccag tctcggaggc ccaggtccac ctggcactgg gggaccagag gttgaacccc

841 acagtcacct atggcaacga ctccttctcg gccaaggcct cagtcagtgt gaccgcagag

901 gacgagggca cccagcggct gacgtgtgca gtaatactgg ggaaccagag ccaggagaca

961 ctgcagacag tgaccatcta cagctttccg gcgcccaacg tgattctgac gaagccagag

1021 gtctcagaag ggaccgaggt gacagtgaag tgtgaggccc accctagagc caaggtgacg

1081 ctgaatgggg ttccagccca gccactgggc ccgagggccc agctcctgct gaaggccacc

1141 ccagaggaca acgggcgcag cttctcctgc tctgcaaccc tggaggtggc cggccagctt

1201 atacacaaga accagacccg ggagcttcgt gtcctgtatg gcccccgact ggacgagagg

1261 gattgtccgg gaaactggac gtggccagaa aattcccagc agactccaat gtgccaggct

1321 tgggggaacc cattgcccga gctcaagtgt ctaaaggatg gcactttccc actgcccatc

1381 ggggaatcag tgactgtcac tcgagatctt gagggcacct acctctgtcg ggccaggagc

1441 actcaagggg aggtcacccg cgaggtgacc gtgaatgtgc tctccccccg gtatgagatt

1501 gtcatcatca ctgtggtagc agccgcagtc ataatgggca ctgcaggcct cagcacgtac

1561 ctctataacc gccagcggaa gatcaagaaa tacagactac aacaggccca aaaagggacc

1621 cccatgaaac cgaacacaca agccacgcct ccctgaacct atcccgggac agggcctctt

1681 cctcggcctt cccatattgg tggcagtggt gccacactga acagagtgga agacatatgc

1741 catgcagcta cacctaccgg ccctgggacg ccggaggaca gggcattgtc ctcagtcaga

1801 tacaacagca tttggggcca tggtacctgc acacctaaaa cactaggcca cgcatctgat

1861 ctgtagtcac atgactaagc caagaggaag gagcaagact caagacatga ttgatggatg

1921 ttaaagtcta gcctgatgag aggggaagtg gtgggggaga catagcccca ccatgaggac

1981 atacaactgg gaaatactga aacttgctgc ctattgggta tgctgaggcc cacagactta

2041 cagaagaagt ggccctccat agacatgtgt agcatcaaaa cacaaaggcc cacacttcct

2101 gacggatgcc agcttgggca ctgctgtcta ctgaccccaa cccttgatga tatgtattta

2161 ttcatttgtt attttaccag ctatttattg agtgtctttt atgtaggcta aatgaacata

2221 ggtctctggc ctcacggagc tcccagtcca tgtcacattc aaggtcacca ggtacagttg

2281 tacaggttgt acactgcagg agagtgcctg gcaaaaagat caaatggggc tgggacttct

2341 cattggccaa cctgcctttc cccagaagga gtgatttttc tatcggcaca aaagcactat

2401 atggactggt aatggttcac aggttcagag attacccagt gaggccttat tcctcccttc

2461 cccccaaaac tgacaccttt gttagccacc tccccaccca catacatttc tgccagtgtt

2521 cacaatgaca ctcagcggtc atgtctggac atgagtgccc agggaatatg cccaagctat

2581 gccttgtcct cttgtcctgt ttgcatttca ctgggagctt gcactattgc agctccagtt

2641 tcctgcagtg atcagggtcc tgcaagcagt ggggaagggg gccaaggtat tggaggactc

2701 cctcccagct ttggaagggt catccgcgtg tgtgtgtgtg tgtatgtgta gacaagctct

2761 cgctctgtca cccaggctgg agtgcagtgg tgcaatcatg gttcactgca gtcttgacct

2821 tttgggctca agtgatcctc ccacctcagc ctcctgagta gctgggacca taggctcaca

2881 acaccacacc tggcaaattt gatttttttt ttttttttca gagacggggt ctcgcaacat

2941 tgcccagact tcctttgtgt tagttaataa agctttctca actgcc

1 gctataagga tcacgcgccc cagtcgacgc tgagctcctc tgctactcag agttgcaacc

61 tcagcctcgc tatggctccc agcagccccc ggcccgcgct gcccgcactc ctggtcctgc

121 tcggggctct gttcccagga cctggcaatg cccagacatc tgtgtccccc tcaaaagtca

181 tcctgccccg gggaggctcc gtgctggtga catgcagcac ctcctgtgac cagcccaagt EPI-109 746

241 tgttgggcat agagaccccg ttgcctaaaa aggagttgct cctgcctggg aacaaccgga

301 aggtgtatga actgagcaat gtgcaagaag atagccaacc aatgtgctat tcaaactgcc

361 ctgatgggca gtcaacagct aaaaccttcc tcaccgtgta ctggactcca gaacgggtgg

421 aactggcacc cctcccctct tggcagccag tgggcaagaa ccttacccta cgctgccagg

481 tggagggtgg ggcaccccgg gccaacctca ccgtggtgct gctccgtggg gagaaggagc

541 tgaaacggga gccagctgtg ggggagcccg ctgaggtcac gaccacggtg ctggtgagga

601 gagatcacca tggagccaat ttctcgtgcc gcactgaact ggacctgcgg ccccaagggc

661 tggagctgtt tgagaacacc tcggccccct accagctcca gacctttgtc ctgccagcga

721 ctcccccaca acttgtcagc ccccgggtcc tagaggtgga cacgcagggg accgtggtct

781 gttccctgga cgggctgttc ccagtctcgg aggcccaggt ccacctggca ctgggggacc

841 agaggttgaa ccccacagtc acctatggca acgactcctt ctcggccaag gcctcagtca

901 gtgtgaccgc agaggacgag ggcacccagc ggctgacgtg tgcagtaata ctggggaacc

961 agagccagga gacactgcag acagtgacca tctacagctt tccggcgccc aacgtgattc

1021 tgacgaagcc agaggtctca gaagggaccg aggtgacagt gaagtgtgag gcccacccta

1081 gagccaaggt gacgctgaat ggggttccag cccagccact gggcccgagg gcccagctcc

1141 tgctgaaggc caccccagag gacaacgggc gcagcttctc ctgctctgca accctggagg

1201 tggccggcca gcttatacac aagaaccaga cccgggagct tcgtgtcctg tatggccccc

1261 gactggacga gagggattgt ccgggaaact ggacgtggcc agaaaattcc cagcagactc

1321 caatgtgcca ggcttggggg aacccattgc ccgagctcaa gtgtctaaag gatggcactt

1381 tcccactgcc catcggggaa tcagtgactg tcactcgaga tcttgagggc acctacctct

1441 gtcgggccag gagcactcaa ggggaggtca cccgcaaggt gaccgtgaat gtgctctccc

1501 cccggtatga gattgtcatc atcactgtgg tagcagccgc agtcataatg ggcactgcag

1561 gcctcagcac gtacctctat aaccgccagc ggaagatcaa gaaatacaga ctacaacagg

1621 cccaaaaagg gacccccatg aaaccgaaca cacaagccac gcctccctga acctatcccg

1681 ggacagggcc tcttcctcgg ccttcccata ttggtggcag tggtgccaca ctgaacagag

1741 tggaagacat atgccatgca gctacaccta ccggccctgg gacgccggag gacagggcat

1801 tgtcctcagt cagatacaac agcatttggg gccatggtac ctgcacacct aaaacactag

1861 gccacgcatc tgatctgtag tcacatgact aagccaagag gaaggagcaa gactcaagac

1921 atgattgatg gatgttaaag tctagcctga tgagagggga agtggtgggg gagacatagc

1981 cccaccatga ggacatacaa ctgggaaata ctgaaacttg ctgcctattg ggtatgctga

2041 ggccccacag acttacagaa gaagtggccc tccatagaca tgtgtagcat caaaacacaa

2101 aggcccacac ttcctgacgg atgccagctt gggcactgct gtctactgac cccaaccctt

2161 gatgatatgt atttattcat ttgttatttt accagctatt tattgagtgt cttttatgta

2221 ggctaaatga acataggtct ctggcctcac ggagctccca gtccatgtca cattcaaggt

2281 caccaggtac agttgtacag gttgtacact gcaggagagt gcctggcaaa aagatcaaat

2341 ggggctggga cttctcattg gccaacctgc ctttccccag aaggagtgat ttttctatcg

2401 gcacaaaagc actatatgga ctggtaatgg ttcacaggtt cagagattac ccagtgaggc

2461 cttattcctc ccttcccccc aaaactgaca cctttgttag ccacctcccc acccacatac

2521 atttctgcca gtgttcacaa tgacactcag cggtcatgtc tggacatgag tgcccaggga

2581 atatgcccaa gctatgcctt gtcctcttgt cctgtttgca tttcactggg agcttgcact

2641 attgcagctc cagtttcctg cagtgatcag ggtcctgcaa gcagtgggga agggggccaa

2701 ggtattggag gactccctcc cagctttgga agcctcatcc gcgtgtgtgt gtgtgtgtgt

2761 atgtgtagac aagctctcgc tctgtcaccc aggctggagt gcagtggtgc aatcatggtt

2821 cactgcagtc ttgacctttt gggctcaagt gatcctccca cctcagcctc ctgagtagct

2881 gggaccatag gctcacaaca ccacacctgg caaatttgat tttttttttt tttttcagag

2941 acggggtctc gcaacattgc ccagacttcc tttgtgttag ttaataaagc tttctcaact

3001 gcc

1 ctcagcctcg ctatggctcc cagcagcccc cggcccgcgc tgcccgcact cctggtcctg

61 ctcggggctc tgttcccagg acctggcaat gcccagacat ctgtgtcccc ctcaaaagtc

121 atcctgcccc ggggaggctc cgtgctggtg acatgcagca cctcctgtga ccagcccaag

181 ttgttgggca tagagacccc gttgcctaaa aaggagttgc tcctgcctgg gaacaaccgg

241 aaggtgtatg aactgagcaa tgtgcaagaa gatagccaac caatgtgcta ttcaaactgc

301 cctgatgggc agtcaacagc taaaaccttc ctcaccgtgt actggactcc agaacgggtg

361 gaactggcac ccctcccctc ttggcagcca gtgggcaaga accttaccct acgctgccag

421 gtggagggtg gggcaccccg ggccaacctc accgtggtgc tgctccgtgg ggagaaggag

481 ctgaaacggg agccagctgt gggggagccc gctgaggtca cgaccacggt gctggtgagg

541 agagatcacc atggagccaa tttctcgtgc cgcactgaac tggacctgcg gccccaaggg

601 ctggagctgt ttgagaacac ctcggccccc taccagctcc agacctttgt cctgccagcg

661 actcccccac aacttgtcag cccccgggtc ctagaggtgg acacgcaggg gaccgtggtc

721 tgttccctgg acgggctgtt cccagtctcg gaggcccagg tccacctggc actgggggac

781 cagaggttga accccacagt cacctatggc aacgactcct tctcggccaa ggcctcagtc

841 agtgtgaccg cagaggacga gggcacccag cggctgacgt gtgcagtaat actggggaac

901 cagagccagg agacactgca gacagtgacc atctacagct ttccggcgcc caacgtgatt

961 ctgacgaagc cagaggtctc agaagggacc gaggtgacag tgaagtgtga ggcccaccct

1021 agagccaagg tgacgctgaa tggggttcca gcccagccac tgggcccgag ggcccagctc

1081 ctgctgaagg ccaccccaga ggacaacggg cgcagcttct cctgctctgc aaccctggag

1141 gtggccggcc agcttataca caagaaccag acccgggagc ttcgtgtcct gtatggcccc

1201 cgactggacg agagggattg tccgggaaac tggacgtggc cagaaaattc ccagcagact EPI-109 747

1261 ccaatgtgcc aggcttgggg gaacccattg cccgagctca agtgtctaaa ggatggcact

1321 ttcccactgc ccatcgggga atcagtgact gtcactcgag atcttgaggg cacctacctc

1381 tgtcgggcca ggagcactca aggggaggtc acccgcgagg tgaccgtgaa tgtgctctcc

1441 ccccggtatg agattgtcat catcactgtg gtagcagccg cagtcataat gggcactgca

1501 ggcctcagca cgtacctcta taaccgccag cggaagatca agaaatacag actacaacag

1561 gcccaaaaag ggacccccat gaaaccgaac acacaagcca cgcctccctg aacctatccc

1621 gggacagggc ctcttcctcg gccttcccat attggtggca gtggtgccac actgaacaga

1681 gtggaagaca tatgccatgc agctacacct accggccctg ggacgccgga ggacagggca

1741 ttgtcctcag tcagatacaa cagcatttgg ggccatggta cctgcacacc taaaacacta 1801 ggccacgcat ctgatctgta gtcacatgac taagccaaga ggaagg

(2) INFORMATION FOR SEQ ID NO: 2572: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4681 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2572:

1 gaattcctgc cactcttcct gcaacggccc aggagctcag agctccacat ctgaccttct

61 agtcatgacc aggaccaggg cagcactcct cctgttcaca gccttagcaa cttctctagg

121 tttcaacttg gacacagagg agctgacagc cttccgtgtg gacagcgctg ggtttggaga

181 cagcgtggtc cagtatgcca actcctgggt ggtggttgga gccccccaaa agataacagc

241 tgccaaccaa acgggtggcc tctaccagtg tggctacagc actggtgcct gtgagcccat

301 cggcctgcag gtgcccccgg aggccgtgaa catgtccctg ggcctgtccc tggcgtctac

361 caccagccct tcccagctgc tggcctgcgg ccccaccgtg caccacgagt gcgggaggaa

421 catgtacctc accggactct gcttcctcct gggccccacc cagctcaccc agaggctccc

481 ggtgtccagg caggagtgcc caagacagga gcaggacatt gtgttcctga tcgatggctc

541 aggcagcatc tcctcccgca actttgccac gatgatgaac ttcgtgagag ctgtgataag

601 ccagttccag agacccagca cccagttttc cctgatgcag ttctccaaca aattccaaac

661 acacttcact ttcgaggaat tcaggcgcac gtcaaacccc ctcagcctgt tggcttctgt

721 tcaccagctg caagggttta catacacggc caccgccatc caaaatgtcg tgcaccgatt

781 gttccatgcc tcatatgggg cccgtaggga tgccaccaaa attctcattg tcatcactga

841 tgggaagaaa gaaggcgaca gcctggatta taaggatgtc atccccatgg ctgatgcagc gθl aggcatcatc cgctatgcaa ttggggttgg attagctttt caaaacagaa attcttggaa

961 agaattaaat gacattgcat cgaagccctc ccaggaacac atatttaaag tggaggactt

1021 tgatgctctg aaagatattc aaaaccaact gaaggagaag atctttgcca ttgagggtac

1081 ggagaccaca agcagtagct ccttcgaatt ggagatggca caggagggct tcagcgctgt

1141 gttcacacct gatggccccg ttctgggggc tgtggggagc ttcacctggt ctggaggtgc

1201 cttcctgtac cccccaaata tgagccctac cttcatcaac atgtctcagg agaatgtgga

1261 catgagggac tcttacctgg gttactccac cgagctggcc ctctggaaag gggtgcagag

1321 cctggtcctg ggggcccccc gctaccagca caccgggaag gctgtcatct tcacccaggt

1381 gtccaggcaa tggaggatga aggccgaagt cacggggact cagatcggct cctacttcgg

1441 ggcctccctc tgctccgtgg acgtagacac cgacggcagc accgacctgg tcctcatcgg

1501 ggccccccat tactacgagc agacccgagg gggccaggtg tctgtgtgtc ccttgcccag

1561 ggggtggaga aggtggtggt gtgatgctgt tctctacggg gagcagggcc acccctgggg

1621 tcgctttggg gcggctctga cagtgctggg ggatgtgaat ggggacaagc tgacagacgt

1681 ggtcatcggg gccccaggag aggaggagaa ccggggtgct gtctacctgt ttcacggagt

1741 cttgggaccc agcatcagcc cctcccacag ccagcggatc gcgggctccc agctctcctc

1801 caggctgcag tattttgggc aggcactgag cgggggtcaa gacctcaccc aggatggact

1861 ggtggacctg gctgtggggg cccggggcca ggtgctcctg ctcaggacca gacctgtgct

1921 ctgggtgggg gtgagcatgc agttcatacc tgccgagatc cccaggtctg cgtttgagtg

1981 tcgggagcag gtggtctctg agcagaccct ggtacagtcc aacatctgcc tttacattga

2041 caaacgttct aagaacctgc ttgggagccg tgacctccaa agctctgtga ccttggacct

2101 ggccctcgac cctggccgcc tgagtccccg tgccaccttc caggaaacaa agaaccggag

2161 tctgagccga gtccgagtcc tcgggctgaa ggcacactgt gaaaacttca acctgctgct

2221 cccgagctgc gtggaggact ctgtgacccc cattaccttg cgtctgaact tcacgctggt

2281 gggcaagccc ctccttgcct tcagaaacct gcggcctatg ctggccgcac tggctcagag

2341 atacttcacg gcctccctac cctttgagaa gaactgtgga gccgaccata tctgccagga

2401 caatctcggc atctccttca gcttcccagg cttgaagtcc ctgctggtgg ggagtaacct

2461 ggagctgaac gcagaagtga tggtgtggaa tgacggggaa gactcctacg gaaccaccat

2521 caccttctcc caccccgcag gactgtccta ccgctacgtg gcagagggcc agaaacaagg

2581 gcagctgcgt tccctgcacc tgacatgtga cagcgcccca gttgggagcc agggcacctg

2641 gagcaccagc tgcagaatca accacctcat cttccgtggc ggcgcccaga tcaccttctt

2701 ggctaccttt gacgtctccc ccaaggctgt cctgggagac cggctgcttc tgacagccaa

2761 tgtgagcagt gagaacaaca ctcccaggac cagcaagacc accttccagc tggagctccc

2821 ggtgaagtat gctgtctaca ctgtggttag cagccacgaa caattcacca aatacctcaa

2881 cttctcagag tctgaggaga aggaaagcca tgtggccatg cacagatacc aggtcaataa

2941 cctgggacag agggacctgc ctgtcagcat caacttctgg gtgcctgtgg agctgaacca

3001 ggaggctgtg tggatggatg tggaggtctc ccacccccag aacccatccc ttcggtgctc EPI-109 748

3061 ctcagagaaa atcgcacccc cagcatctga cttcctggcg cacattcaga agaatcccgt

3121 gctggactgc tccattgctg gctgcctgcg gttccgctgt gacgtcccct ccttcagcgt

3181 ccaggaggag ctggatttca ccctgaaggg caacctcagc tttggctggg tccgccagat

3241 attgcagaag aaggtgtcgg tcgtgagtgt ggctgaaatt acgttcgaca catccgtgta

3301 ctcccagctt ccaggacagg aggcatttat gagagctcag acgacaacgg tgctggagaa

3361 gtacaaggtc cacaacccca cccccctcat cgtaggcagc tccattgggg gtctgttgct

3421 gctggcactc atcacagcgg tactgtacaa agttggcttc ttcaagcgtc agtacaagga

3481 aatgatggag gaggcaaatg gacaaattgc cccagaaaac gggacacaga cccccagccc

3541 gcccagtgag aaatgatccc tctttgcctt ggacttcttc tcccgcgatt ttccccactt

3601 acttaccctc acctgtcagg ctgacgggga ggaaccactg caccaccgag agaggctggg

3661 atgggcctgc ttcctgtctt tgggagaaaa cgtcttgctt gggaaggggc ctttgtcttg

3721 tcaaggttcc aactggaaac ccttaggaca gggtccctgc tgtgttcccc aaaaggactt

3781 gacttgcaat ttctacctag aaatacatgg acaatacccc caggcctcag tctcccttct

3841 cccatgaggc acgaatgatc tttctttcct ttcctttttt ttttttttct tttctttttt

3901 tttttttttg agacggagtc tcgctctgtc acccaggctg gagtgcaatg gcgtgatctc

3961 ggctcgctgc aacctccgcc tcccgggttc aagtaattct gctgtctcag cctcctgcgt

4021 agctgggact acaggcacac gccacctcgc ccggcccgat ctttctaaaa tacagttctg

4081 aatatgctgc tcatccccac ctgtcttcaa cagctcccca ttaccctcag gacaatgtct

4141 gaactctcca gcttcgcgtg agaagtcccc ttccatccca gagggtgggc ttcagggcgc

4201 acagcatgag agcctctgtg cccccatcac cctcgtttcc agtgaattag tgtcatgtca

4261 gcatcagctc agggcttcat cgtggggctc tcagttccga ttccccaggc tgaattggga

4321 gtgagatgcc tgcatgctgg gttctgcaca gctggcctcc cgcggttggg tcaacattgc

4381 tggcctggaa gggaggagcg ccctctaggg agggacatgg ccccggtgcg gctgcagctc

4441 accagcccca ggggcagaag agacccaacc acttcctatt ttttgaggct atgaatatag

4501 tacctgaaaa aatgccaagc actagattat ttttttaaaa agcgtacttt aaatgtttgt

4561 gttaatacac attaaaacat cgcacaaaaa cgatgcatct accgctcctt gggaaataat

4621 ctgaaaggtc taaaaataaa aaagccttct gtggaaaaaa aaaaaaaaaa aaaaaaaaaa

4681 aaaaaaaaaa aaaaaaaaaa aaaa

(2) INFORMATION FOR SEQ ID NO:2573:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4621 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2573:

1 gaattcctgc cactcttcct gcaacggccc aggagctcag agctccacat ctgaccttct

61 agtcatgacc aggaccaggg cagcactcct cctgttcaca gccttagcaa cttctctagg

121 tttcaacttg gacacagagg agctgacagc cttccgtgtg gacagcgctg ggtttggaga

181 cagcgtggtc cagtatgcca actcctgggt ggtggttgga gccccccaaa agataacagc

241 tgccaaccaa acgggtggcc tctaccagtg tggctacagc actggtgcct gtgagcccat

301 cggcctgcag gtgcccccgg aggccgtgaa catgtccctg ggcctgtccc tggcgtctac

361 caccagccct tcccagctgc tggcctgcgg ccccaccgtg caccacgagt gcgggaggaa

421 catgtacctc accggactct gcttcctcct gggccccacc cagctcaccc agaggctccc

481 ggtgtccagg caggagtgcc caagacagga gcaggacatt gtgttcctga tcgatggctc

541 aggcagcatc tcctcccgca actttgccac gatgatgaac ttcgtgagag ctgtgataag

601 ccagttccag agacccagca cccagttttc cctgatgcag ttctccaaca aattccaaac

661 acacttcact ttcgaggaat tcaggcgcac gtcaaacccc ctcagcctgt tggcttctgt

721 tcaccagctg caagggttta catacacggc caccgccatc caaaatgtcg tgcaccgatt

781 gttccatgcc tcatatgggg cccgtaggga tgccaccaaa attctcattg tcatcactga

841 tgggaagaaa gaaggcgaca gcctggatta taaggatgtc atccccatgg ctgatgcagc

901 aggcatcatc cgctatgcaa ttggggttgg attagctttt caaaacagaa attcttggaa

961 agaattaaat gacattgcat cgaagccctc ccaggaacac atatttaaag tggaggactt

1021 tgatgctctg aaagatattc aaaaccaact gaaggagaag atctttgcca ttgagggtac

1081 ggagaccaca agcagtagct ccttcgaatt ggagatggca caggagggct tcagcgctgt

1141 gttcacacct gatggccccg ttctgggggc tgtggggagc ttcacctggt ctggaggtgc

1201 cttcctgtac cccccaaata tgagccctac cttcatcaac atgtctcagg agaatgtgga

1261 catgagggac tcttacctgg gttactccac cgagctggcc ctctggaaag gggtgcagag

1321 cctggtcctg ggggcccccc gctaccagca caccgggaag gctgtcatct tcacccaggt

1381 gtccaggcaa tggaggatga aggccgaagt cacggggact cagatcggct cctacttcgg

1441 ggcctccctc tgctccgtgg acgtagacac cgacggcagc accgacctgg tcctcatcgg

1501 ggccccccat tactacgagc agacccgagg gggccaggtg tctgtgtgtc ccttgcccag

1561 ggggtggaga aggtggtggt gtgatgctgt tctctacggg gagcagggcc acccctgggg

1621 tcgctttggg gcggctctga cagtgctggg ggatgtgaat ggggacaagc tgacagacgt

1681 ggtcatcggg gccccaggag aggaggagaa ccggggtgct gtctacctgt ttcacggagt

1741 cttgggaccc agcatcagcc cctcccacag ccagcggatc gcgggctccc agctctcctc

1801 caggctgcag tattttgggc aggcactgag cgggggtcaa gacctcaccc aggatggact

1861 ggtggacctg gctgtggggg cccggggcca ggtgctcctg ctcaggacca gacctgtgct

1921 ctgggtgggg gtgagcatgc agttcatacc tgccgagatc cccaggtctg cgtttgagtg EPI-109 749

1981 tcgggagcag gtggtctctg agcagaccct ggtacagtcc aacatctgcc tttacattga 2041 caaacgttct aagaacctgc ttgggagccg tgacctccaa agctctgtga ccttggacct 2101 ggccctcgac cctggccgcc tgagtccccg tgccaccttc caggaaacaa agaaccggag 2161 tctgagccga gtccgagtcc tcgggctgaa ggcacactgt gaaaacttca acctgctgct 2221 cccgagctgc gtggaggact ctgtgacccc cattaccttg cgtctgaact tcacgctggt 2281 gggcaagccc ctccttgcct tcagaaacct gcggcctatg ctggccgcac tggctcagag 2341 atacttcacg gcctccctac cctttgagaa gaactgtgga gccgaccata tctgccagga 2401 caatctcggc atctccttca gcttcccagg cttgaagtcc ctgctggtgg ggagtaacct 2461 ggagctgaac gcagaagtga tggtgtggaa tgacggggaa gactcctacg gaaccaccat 2521 caccttctcc caccccgcag gactgtccta ccgctacgtg gcagagggcc agaaacaagg 2581 gcagctgcgt tccctgcacc tgacatgtga cagcgcccca gttgggagcc agggcacctg 2641 gagcaccagc tgcagaatca accacctcat cttccgtggc ggcgcccaga tcaccttctt 2701 ggctaccttt gacgtctccc ccaaggctgt cctgggagac cggctgcttc tgacagccaa 2761 tgtgagcagt gagaacaaca ctcccaggac cagcaagacc accttccagc tggagctccc 2821 ggtgaagtat gctgtctaca ctgtggttag cagccacgaa caattcacca aatacctcaa 2881 cttctcagag tctgaggaga aggaaagcca tgtggccatg cacagatacc aggtcaataa 2941 cctgggacag agggacctgc ctgtcagcat caacttctgg gtgcctgtgg agctgaacca 3001 ggaggctgtg tggatggatg tggaggtctc ccacccccag aacccatccc ttcggtgctc 3061 ctcagagaaa atcgcacccc cagcatctga cttcctggcg cacattcaga agaatcccgt 3121 gctggactgc tccattgctg gctgcctgcg gttccgctgt gacgtcccct ccttcagcgt 3181 ccaggaggag ctggatttca ccctgaaggg caacctcagc tttggctggg tccgccagat 3241 attgcagaag aaggtgtcgg tcgtgagtgt ggctgaaatt acgttcgaca catccgtgta 3301 ctcccagctt ccaggacagg aggcatttat gagagctcag acgacaacgg tgctggagaa 3361 gtacaaggtc cacaacccca cccccctcat cgtaggcagc tccattgggg gtctgttgct 3421 gctggcactc atcacagcgg tactgtacaa agttggcttc ttcaagcgtc agtacaagga 3481 aatgatggag gaggcaaatg gacaaattgc cccagaaaac gggacacaga cccccagccc 3541 gcccagtgag aaatgatccc tctttgcctt ggacttcttc tcccgcgatt ttccccactt 3601 acttaccctc acctgtcagg ctgacgggga ggaaccactg caccaccgag agaggctggg 3661 atgggcctgc ttcctgtctt tgggagaaaa cgtcttgctt gggaaggggc ctttgtcttg 3721 tcaaggttcc aactggaaac ccttaggaca gggtccctgc tgtgttcccc aaaaggactt 3781 gacttgcaat ttctacctag aaatacatgg acaatacccc caggcctcag tctcccttct 3841 cccatgaggc acgaatgatc tttctttcct ttcctttttt ttttttttct tttctttttt 3901 tttttttttg agacggagtc tcgctctgtc acccaggctg gagtgcaatg gcgtgatctc 3961 ggctcgctgc aacctccgcc tcccgggttc aagtaattct gctgtctcag cctcctgcgt 4021 agctgggact acaggcacac gccacctcgc ccggcccgat ctttctaaaa tacagttctg 4081 aatatgctgc tcatccccac ctgtcttcaa cagctcccca ttaccctcag gacaatgtct 4141 gaactctcca gcttcgcgtg agaagtcccc ttccatccca gagggtgggc ttcagggcgc 4201 acagcatgag agcctctgtg cccccatcac cctcgtttcc agtgaattag tgtcatgtca 4261 gcatcagctc agggcttcat cgtggggctc tcagttccga ttccccaggc tgaattggga 4321 gtgagatgcc tgcatgctgg gttctgcaca gctggcctcc cgcggttggg tcaacattgc 4381 tggcctggaa gggaggagcg ccctctaggg agggacatgg ccccggtgcg gctgcagctc 4441 accagcccca ggggcagaag agacccaacc acttcctatt ttttgaggct atgaatatag 4501 tacctgaaaa aatgccaagc actagattat ttttttaaaa agcgtacttt aaatgtttgt 4561 gttaatacac attaaaacat cgcacaaaaa cgatgcatct accgctcctt gggaaataat 4621 ctgaaaggtc taaaaataaa aaagccttct gtgg

(2) INFORMATION FOR SEQ ID NO: 2574: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2281 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2574:

1 ctcgccctgg tggggctgct ctccctcggg tgcgtcctct ctcaggagtg cacgaagttc

61 aaggtcagca gctgccggga atgcatcgag tcggggcccg gctgcacctg gtgccagaag

121 ctgaacttca cagggccggg ggatcctgac tccattcgct gcgacacccg gccacagctg

181 ctcatgaggg gctgtgcggc tgacgacatc atggacccca caagcctcgc tgaaacccag

241 gaagaccaca atgggggcca gaagcagctg tccccacaaa aagtgacgct ttacctgcga

301 ccaggccagg cagcagcgtt caacgtgacc ttccggcggg ccaagggcta ccccatcgac

361 ctgtactatc tgatggacct ctcctactcc atgcttgatg acctcaggaa tgtcaagaag

421 ctaggtggcg acctgctccg ggccctcaac gagatcaccg agtccggccg cattggcttc

481 gggtccttcg tggacaagac cgtgctgccg ttcgtgaaca cgcaccctga taagctgcga

541 aacccatgcc ccaacaagga gaaagagtgc ccgcccccgt ttgccttcag gcacgtgctg

601 aagctgacca acaactccaa ccagtttcag accgaggtcg ggaagcagct gatttccgga

661 aacctggatg cacccgaggg tgggctggac gccatgatgc aggtcgccgc ctgcccggag

721 gaaatcggct ggcgcaacgt cacgcggctg ctggtgtttg ccactgatga cggcttccat

781 ttcgcgggcg acggaaagct gggcgccatc ctgaccccca acgacggccg ctgtcacctg

841 gaggacaact t tacaagag gagcaacgaa ttcgactacc catcggtggg ccagctggcg

901 cacaagctgg ctgaaaacaa catccagccc atcttcgcgg tgaccagtag gatggtgaag EPI-109 750

961 acctacgaga aactcaccga gatcatcccc aagtcagccg tgggggagct gtctgaggac 1021 tccagcaatg tggtccatct cattaagaat gcttacaata aactctcctc cagggtcttc 1081 ctggatcaca acgccctccc cgacaccctg aaagtcacct acgactcctt ctgcagcaat 1141 ggagtgacgc acaggaacca gcccagaggt gactgtgatg gcgtgcagat caatgtcccg 1201 atcaccttcc aggtgaaggt cacggccaca gagtgcatcc aggagcagtc gtttgtcatc 1261 cgggcgctgg gcttcacgga catagtgacc gtgcaggtcc ttccccagtg tgagtgccgg 1321 tgccgggacc agagcagaga ccgcagcctc tgccatggca agggcttctt ggagtgcggc 1381 atctgcaggt gtgacactgg ctacattggg aaaaactgtg agtgccagac acagggccgg 1441 agcagccagg agctggaagg aagctgccgg aaggacaaca actccatcat ctgctcaggg 1501 ctgggggact gtgtctgcgg gcagtgcctg tgccacacca gcgacgtccc cggcaagctg 1561 atatacgggc agtactgcga gtgtgacacc atcaactgtg agcgctacaa cggccaggtc 1621 tgcggcggcc cggggagggg gctctgcttc tgcgggaagt gccgctgcca cccgggcttt 1681 gagggctcag cgtgccagtg cgagaggacc actgagggct gcctgaaccc gcggcgtgtt 1741 gagtgtagtg gtcgtggccg gtgccgctgc aacgtatgcg agtgccattc aggctaccag 1801 ctgcctctgt gccaggagtg ccccggctgc ccctcaccct gtggcaagta catctcctgc 1861 gccgagtgcc tgaagttcga aaagggcccc tttgggaaga actgcagcgc ggcgtgtccg 1921 ggcctgcagc tgtcgaacaa ccccgtgaag ggcaggacct gcaaggagag ggactcagag 1981 ggctgctggg tggcctacac gctggagcag caggacggga tggaccgcta cctcatctat 2041 gtggatgaga gccgagagtg tgtggcaggc cccaacatcg ccgccatcgt cgggggcacc 2101 gtggcaggca tcgtgctgat cggcattctc ctgctggtca tctggaaggc tctgatccac 2161 ctgagcgacc tccgggagta caggcgcttt gagaaggaga agctcaagtc ccagtggaac 2221 aatgataatc cccttttcaa gagcgccacc acgacggtca tgaaccccaa gtttgctgag 2281 agttaggagc a

(2) INFORMATION FOR SEQ ID NO: 2575: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 11583 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2575:

1 gaattcctgc cactcttcct gcaacggccc aggagctcag agctccacat ctgaccttct

61 agtcatgacc aggaccaggg cagcactcct cctgttcaca gccttagcaa cttctctagg

121 tttcaacttg gacacagagg agctgacagc cttccgtgtg gacagcgctg ggtttggaga

181 cagcgtggtc cagtatgcca actcctgggt ggtggttgga gccccccaaa agataacagc

241 tgccaaccaa acgggtggcc tctaccagtg tggctacagc actggtgcct gtgagcccat

301 cggcctgcag gtgcccccgg aggccgtgaa catgtccctg ggcctgtccc tggcgtctac

361 caccagccct tcccagctgc tggcctgcgg ccccaccgtg caccacgagt gcgggaggaa

421 catgtacctc accggactct gcttcctcct gggccccacc cagctcaccc agaggctccc

481 ggtgtccagg caggagtgcc caagacagga gcaggacatt gtgttcctga tcgatggctc

541 aggcagcatc tcctcccgca actttgccac gatgatgaac ttcgtgagag ctgtgataag

601 ccagttccag agacccagca cccagttttc cctgatgcag ttctccaaca aattccaaac

661 acacttcact ttcgaggaat tcaggcgcac gtcaaacccc ctcagcctgt tggcttctgt

721 tcaccagctg caagggttta catacacggc caccgccatc caaaatgtcg tgcaccgatt

781 gttccatgcc tcatatgggg cccgtaggga tgccaccaaa attctcattg tcatcactga

841 tgggaagaaa gaaggcgaca gcctggatta taaggatgtc atccccatgg ctgatgcagc

901 aggcatcatc cgctatgcaa ttggggttgg attagctttt caaaacagaa attcttggaa

961 agaattaaat gacattgcat cgaagccctc ccaggaacac atatttaaag tggaggactt

1021 tgatgctctg aaagatattc aaaaccaact gaaggagaag atctttgcca ttgagggtac

1081 ggagaccaca agcagtagct ccttcgaatt ggagatggca caggagggct tcagcgctgt

1141 gttcacacct gatggccccg ttctgggggc tgtggggagc ttcacctggt ctggaggtgc

1201 cttcctgtac cccccaaata tgagccctac cttcatcaac atgtctcagg agaatgtgga

1261 catgagggac tcttacctgg gttactccac cgagctggcc ctctggaaag gggtgcagag

1321 cctggtcctg ggggcccccc gctaccagca caccgggaag gctgtcatct tcacccaggt

1381 gtccaggcaa tggaggatga aggccgaagt cacggggact cagatcggct cctacttcgg

1441 ggcctccctc tgctccgtgg acgtagacac cgacggcagc accgacctgg tcctcatcgg

1501 ggccccccat tactacgagc agacccgagg gggccaggtg tctgtgtgtc ccttgcccag

1561 ggggtggaga aggtggtggt gtgatgctgt tctctacggg gagcagggcc acccctgggg

1621 tcgctttggg gcggctctga cagtgctggg ggatgtgaat ggggacaagc tgacagacgt

1681 ggtcatcggg gccccaggag aggaggagaa ccggggtgct gtctacctgt ttcacggagt

1741 cttgggaccc agcatcagcc cctcccacag ccagcggatc gcgggctccc agctctcctc

1801 caggctgcag tattttgggc aggcactgag cgggggtcaa gacctcaccc aggatggact

1861 ggtggacctg gctgtggggg cccggggcca ggtgctcctg ctcaggacca gacctgtgct

1921 ctgggtgggg gtgagcatgc agttcatacc tgccgagatc cccaggtctg cgtttgagtg

1981 tcgggagcag gtggtctctg agcagaccct ggtacagtcc aacatctgcc tttacattga

2041 caaacgttct aagaacctgc ttgggagccg tgacctccaa agctctgtga ccttggacct

2101 ggccctcgac cctggccgcc tgagtccccg tgccaccttc caggaaacaa agaaccggag

2161 tctgagccga gtccgagtcc tcgggctgaa ggcacactgt gaaaacttca acctgctgct

2221 cccgagctgc gtggaggact ctgtgacccc cattaccttg cgtctgaact tcacgctggt EPI-109 751

2281 gggcaagccc ctccttgcct tcagaaacct gcggcctatg ctggccgcac tggctcagag 2341 atacttcacg gcctccctac cctttgagaa gaactgtgga gccgaccata tctgccagga 2401 caatctcggc atctccttca gcttcccagg cttgaagtcc ctgctggtgg ggagtaacct 2461 ggagctgaac gcagaagtga tggtgtggaa tgacggggaa gactcctacg gaaccaccat 2521 caccttctcc caccccgcag gactgtccta ccgctacgtg gcagagggcc agaaacaagg 2581 gcagctgcgt tccctgcacc tgacatgtga cagcgcccca gttgggagcc agggcacctg 2641 gagcaccagc tgcagaatca accacctcat cttccgtggc ggcgcccaga tcaccttctt 2701 ggctaccttt gacgtctccc ccaaggctgt cctgggagac cggctgcttc tgacagccaa 2761 tgtgagcagt gagaacaaca ctcccaggac cagcaagacc accttccagc tggagctccc 2821 ggtgaagtat gctgtctaca ctgtggttag cagccacgaa caattcacca aatacctcaa 2881 cttctcagag tctgaggaga aggaaagcca tgtggccatg cacagatacc aggtcaataa 2941 cctgggacag agggacctgc ctgtcagcat caacttctgg gtgcctgtgg agctgaacca 3001 ggaggctgtg tggatggatg tggaggtctc ccacccccag aacccatccc ttcggtgctc 3061 ctcagagaaa atcgcacccc cagcatctga cttcctggcg cacattcaga agaatcccgt 3121 gctggactgc tccattgctg gctgcctgcg gttccgctgt gacgtcccct ccttcagcgt 3181 ccaggaggag ctggatttca ccctgaaggg caacctcagc tttggctggg tccgccagat 3241 attgcagaag aaggtgtcgg tcgtgagtgt ggctgaaatt acgttcgaca catccgtgta 3301 ctcccagctt ccaggacagg aggcatttat gagagctcag acgacaacgg tgctggagaa 3361 gtacaaggtc cacaacccca cccccctcat cgtaggcagc tccattgggg gtctgttgct 3421 gctggcactc atcacagcgg tactgtacaa agttggcttc ttcaagcgtc agtacaagga 3481 aatgatggag gaggcaaatg gacaaattgc cccagaaaac gggacacaga cccccagccc 3541 gcccagtgag aaatgatccc tctttgcctt ggacttcttc tcccgcgatt ttccccactt 3601 acttaccctc acctgtcagg ctgacgggga ggaaccactg caccaccgag agaggctggg 3661 atgggcctgc ttcctgtctt tgggagaaaa cgtcttgctt gggaaggggc ctttgtcttg 3721 tcaaggttcc aactggaaac ccttaggaca gggtccctgc tgtgttcccc aaaaggactt 3781 gacttgcaat ttctacctag aaatacatgg acaatacccc caggcctcag tctcccttct 3841 cccatgaggc acgaatgatc tttctttcct ttcctttttt ttttttttct tttctttttt 3901 tttttttttg agacggagtc tcgctctgtc acccaggctg gagtgcaatg gcgtgatctc 3961 ggctcgctgc aacctccgcc tcccgggttc aagtaattct gctgtctcag cctcctgcgt 4021 agctgggact acaggcacac gccacctcgc ccggcccgat ctttctaaaa tacagttctg 4081 aatatgctgc tcatccccac ctgtcttcaa cagctcccca ttaccctcag gacaatgtct 4141 gaactctcca gcttcgcgtg agaagtcccc ttccatccca gagggtgggc ttcagggcgc 4201 acagcatgag agcctctgtg cccccatcac cctcgtttcc agtgaattag tgtcatgtca 4261 gcatcagctc agggcttcat cgtggggctc tcagttccga ttccccaggc tgaattggga 4321 gtgagatgcc tgcatgctgg gttctgcaca gctggcctcc cgcggttggg tcaacattgc 4381 tggcctggaa gggaggagcg ccctctaggg agggacatgg ccccggtgcg gctgcagctc 4441 accagcccca ggggcagaag agacccaacc acttcctatt ttttgaggct atgaatatag 4501 tacctgaaaa aatgccaagc actagattat ttttttaaaa agcgtacttt aaatgtttgt 4561 gttaatacac attaaaacat cgcacaaaaa cgatgcatct accgctcctt gggaaataat 4621 ctgaaaggtc taaaaataaa aaagccttct gtggaaaaaa aaaaaaaaaa aaaaaaaaaa 4681 aaaaaaaaaa aaaaaaaaaa aaaa

1 gaattcctgc cactcttcct gcaacggccc aggagctcag agctccacat ctgaccttct

61 agtcatgacc aggaccaggg cagcactcct cctgttcaca gccttagcaa cttctctagg

121 tttcaacttg gacacagagg agctgacagc cttccgtgtg gacagcgctg ggtttggaga

181 cagcgtggtc cagtatgcca actcctgggt ggtggttgga gccccccaaa agataacagc

241 tgccaaccaa acgggtggcc tctaccagtg tggctacagc actggtgcct gtgagcccat

301 cggcctgcag gtgcccccgg aggccgtgaa catgtccctg ggcctgtccc tggcgtctac

361 caccagccct tcccagctgc tggcctgcgg ccccaccgtg caccacgagt gcgggaggaa

421 catgtacctc accggactct gcttcctcct gggccccacc cagctcaccc agaggctccc

481 ggtgtccagg caggagtgcc caagacagga gcaggacatt gtgttcctga tcgatggctc

541 aggcagcatc tcctcccgca actttgccac gatgatgaac ttcgtgagag ctgtgataag

601 ccagttccag agacccagca cccagttttc cctgatgcag ttctccaaca aattccaaac

661 acacttcact ttcgaggaat tcaggcgcac gtcaaacccc ctcagcctgt tggcttctgt

721 tcaccagctg caagggttta catacacggc caccgccatc caaaatgtcg tgcaccgatt

781 gttccatgcc tcatatgggg cccgtaggga tgccaccaaa attctcattg tcatcactga

841 tgggaagaaa gaaggcgaca gcctggatta taaggatgtc atccccatgg ctgatgcagc

901 aggcatcatc cgctatgcaa ttggggttgg attagctttt caaaacagaa attcttggaa

961 agaattaaat gacattgcat cgaagccctc ccaggaacac atatttaaag tggaggactt

1021 tgatgctctg aaagatattc aaaaccaact gaaggagaag atctttgcca ttgagggtac

1081 ggagaccaca agcagtagct ccttcgaatt ggagatggca caggagggct tcagcgctgt

1141 gttcacacct gatggccccg ttctgggggc tgtggggagc ttcacctggt ctggaggtgc

1201 cttcctgtac cccccaaata tgagccctac cttcatcaac atgtctcagg agaatgtgga

1261 catgagggac tcttacctgg gttactccac cgagctggcc ctctggaaag gggtgcagag

1321 cctggtcctg ggggcccccc gctaccagca caccgggaag gctgtcatct tcacccaggt

1381 gtccaggcaa tggaggatga aggccgaagt cacggggact cagatcggct cctacttcgg

1441 ggcctccctc tgctccgtgg acgtagacac cgacggcagc accgacctgg tcctcatcgg

1501 ggccccccat tactacgagc agacccgagg gggccaggtg tctgtgtgtc ccttgcccag

1561 ggggtggaga aggtggtggt gtgatgctgt tctctacggg gagcagggcc acccctgggg EPI-109 752

1621 tcgctttggg gcggctctga cagtgctggg ggatgtgaat ggggacaagc tgacagacgt 1681 ggtcatcggg gccccaggag aggaggagaa ccggggtgct gtctacctgt ttcacggagt 1741 cttgggaccc agcatcagcc cctcccacag ccagcggatc gcgggctccc agctctcctc 1801 caggctgcag tattttgggc aggcactgag cgggggtcaa gacctcaccc aggatggact 1861 ggtggacctg gctgtggggg cccggggcca ggtgctcctg ctcaggacca gacctgtgct 1921 ctgggtgggg gtgagcatgc agttcatacc tgccgagatc cccaggtctg cgtttgagtg 1981 tcgggagcag gtggtctctg agcagaccct ggtacagtcc aacatctgcc tttacattga 2041 caaacgttct aagaacctgc ttgggagccg tgacctccaa agctctgtga ccttggacct 2101 ggccctcgac cctggccgcc tgagtccccg tgccaccttc caggaaacaa agaaccggag 2161 tctgagccga gtccgagtcc tcgggctgaa ggcacactgt gaaaacttca acctgctgct 2221 cccgagctgc gtggaggact ctgtgacccc cattaccttg cgtctgaact tcacgctggt 2281 gggcaagccc ctccttgcct tcagaaacct gcggcctatg ctggccgcac tggctcagag 2341 atacttcacg gcctccctac cctttgagaa gaactgtgga gccgaccata tctgccagga 2401 caatctcggc atctccttca gcttcccagg cttgaagtcc ctgctggtgg ggagtaacct 2461 ggagctgaac gcagaagtga tggtgtggaa tgacggggaa gactcctacg gaaccaccat 2521 caccttctcc caccccgcag gactgtccta ccgctacgtg gcagagggcc agaaacaagg 2581 gcagctgcgt tccctgcacc tgacatgtga cagcgcccca gttgggagcc agggcacctg 2641 gagcaccagc tgcagaatca accacctcat cttccgtggc ggcgcccaga tcaccttctt 2701 ggctaccttt gacgtctccc ccaaggctgt cctgggagac cggctgcttc tgacagccaa 2761 tgtgagcagt gagaacaaca ctcccaggac cagcaagacc accttccagc tggagctccc 2821 ggtgaagtat gctgtctaca ctgtggttag cagccacgaa caattcacca aatacctcaa 2881 cttctcagag tctgaggaga aggaaagcca tgtggccatg cacagatacc aggtcaataa 2941 cctgggacag agggacctgc ctgtcagcat caacttctgg gtgcctgtgg agctgaacca 3001 ggaggctgtg tggatggatg tggaggtctc ccacccccag aacccatccc ttcggtgctc 3061 ctcagagaaa atcgcacccc cagcatctga cttcctggcg cacattcaga agaatcccgt 3121 gctggactgc tccattgctg gctgcctgcg gttccgctgt gacgtcccct ccttcagcgt 3181 ccaggaggag ctggatttca ccctgaaggg caacctcagc tttggctggg tccgccagat 3241 attgcagaag aaggtgtcgg tcgtgagtgt ggctgaaatt acgttcgaca catccgtgta 3301 ctcccagctt ccaggacagg aggcatttat gagagctcag acgacaacgg tgctggagaa 3361 gtacaaggtc cacaacccca cccccctcat cgtaggcagc tccattgggg gtctgttgct 3421 gctggcactc atcacagcgg tactgtacaa agttggcttc ttcaagcgtc agtacaagga 3481 aatgatggag gaggcaaatg gacaaattgc cccagaaaac gggacacaga cccccagccc 3541 gcccagtgag aaatgatccc tctttgcctt ggacttcttc tcccgcgatt ttccccactt 3601 acttaccctc acctgtcagg ctgacgggga ggaaccactg caccaccgag agaggctggg 3661 atgggcctgc ttcctgtctt tgggagaaaa cgtcttgctt gggaaggggc ctttgtcttg 3721 tcaaggttcc aactggaaac ccttaggaca gggtccctgc tgtgttcccc aaaaggactt 3781 gacttgcaat ttctacctag aaatacatgg acaatacccc caggcctcag tctcccttct 3841 cccatgaggc acgaatgatc tttctttcct ttcctttttt ttttttttct tttctttttt 3901 tttttttttg agacggagtc tcgctctgtc acccaggctg gagtgcaatg gcgtgatctc 3961 ggctcgctgc aacctccgcc tcccgggttc aagtaattct gctgtctcag cctcctgcgt 4021 agctgggact acaggcacac gccacctcgc ccggcccgat ctttctaaaa tacagttctg 4081 aatatgctgc tcatccccac ctgtcttcaa cagctcccca ttaccctcag gacaatgtct 4141 gaactctcca gcttcgcgtg agaagtcccc ttccatccca gagggtgggc ttcagggcgc 4201 acagcatgag agcctctgtg cccccatcac cctcgtttcc agtgaattag tgtcatgtca 4261 gcatcagctc agggcttcat cgtggggctc tcagttccga ttccccaggc tgaattggga 4321 gtgagatgcc tgcatgctgg gttctgcaca gctggcctcc cgcggttggg tcaacattgc 4381 tggcctggaa gggaggagcg ccctctaggg agggacatgg ccccggtgcg gctgcagctc 4441 accagcccca ggggcagaag agacccaacc acttcctatt ttttgaggct atgaatatag 4501 tacctgaaaa aatgccaagc actagattat ttttttaaaa agcgtacttt aaatgtttgt 4561 gttaatacac attaaaacat cgcacaaaaa cgatgcatct accgctcctt gggaaataat 4621 ctgaaaggtc taaaaataaa aaagccttct gtgg

1 ctcgccctgg tggggctgct ctccctcggg tgcgtcctct ctcaggagtg cacgaagttc 61 aaggtcagca gctgccggga atgcatcgag tcggggcccg gctgcacctg gtgccagaag 121 ctgaacttca cagggccggg ggatcctgac tccattcgct gcgacacccg gccacagctg 181 ctcatgaggg gctgtgcggc tgacgacatc atggacccca caagcctcgc tgaaacccag 241 gaagaccaca atgggggcca gaagcagctg tccccacaaa aagtgacgct ttacctgcga 301 ccaggccagg cagcagcgtt caacgtgacc ttccggcggg ccaagggcta ccccatcgac 361 ctgtactatc tgatggacct ctcctactcc atgcttgatg acctcaggaa tgtcaagaag 421 ctaggtggcg acctgctccg ggccctcaac gagatcaccg agtccggccg cattggcttc 481 gggtccttcg tggacaagac cgtgctgccg ttcgtgaaca cgcaccctga taagctgcga 541 aacccatgcc ccaacaagga gaaagagtgc ccgcccccgt ttgccttcag gcacgtgctg 601 aagctgacca acaactccaa ccagtttcag accgaggtcg ggaagcagct gatttccgga 661 aacctggatg cacccgaggg tgggctggac gccatgatgc aggtcgccgc ctgcccggag 721 gaaatcggct ggcgcaacgt cacgcggctg ctggtgtttg ccactgatga cggcttccat 781 ttcgcgggcg acggaaagct gggcgccatc ctgaccccca acgacggccg ctgtcacctg 841 gaggacaact tgtacaagag gagcaacgaa ttcgactacc catcggtggg ccagctggcg 901 cacaagctgg ctgaaaacaa catccagccc atcttcgcgg tgaccagtag gatggtgaag 961 acctacgaga aactcaccga gatcatcccc aagtcagccg tgggggagct gtctgaggac EPI-109 753

1021 tccagcaatg tggtccatct cattaagaat gcttacaata aactctcctc cagggtcttc 1081 ctggatcaca acgccctccc cgacaccctg aaagtcacct acgactcctt ctgcagcaat 1141 ggagtgacgc acaggaacca gcccagaggt gactgtgatg gcgtgcagat caatgtcccg 1201 atcaccttcc aggtgaaggt cacggccaca gagtgcatcc aggagcagtc gtttgtcatc 1261 cgggcgctgg gcttcacgga catagtgacc gtgcaggtcc ttccccagtg tgagtgccgg 1321 tgccgggacc agagcagaga ccgcagcctc tgccatggca agggcttctt ggagtgcggc 1381 atctgcaggt gtgacactgg ctacattggg aaaaactgtg agtgccagac acagggccgg 1441 agcagccagg agctggaagg aagctgccgg aaggacaaca actccatcat ctgctcaggg 1501 ctgggggact gtgtctgcgg gcagtgcctg tgccacacca gcgacgtccc cggcaagctg 1561 atatacgggc agtactgcga gtgtgacacc atcaactgtg agcgctacaa cggccaggtc 1621 tgcggcggcc cggggagggg gctctgcttc tgcgggaagt gccgctgcca cccgggcttt 1681 gagggctcag cgtgccagtg cgagaggacc actgagggct gcctgaaccc gcggcgtgtt 1741 gagtgtagtg gtcgtggccg gtgccgctgc aacgtatgcg agtgccattc aggctaccag 1801 ctgcctctgt gccaggagtg ccccggctgc ccctcaccct gtggcaagta catctcctgc 1861 gccgagtgcc tgaagttcga aaagggcccc tttgggaaga actgcagcgc ggcgtgtccg 1921 ggcctgcagc tgtcgaacaa ccccgtgaag ggcaggacct gcaaggagag ggactcagag 1981 ggctgctggg tggcctacac gctggagcag caggacggga tggaccgcta cctcatctat 2041 gtggatgaga gccgagagtg tgtggcaggc cccaacatcg ccgccatcgt cgggggcacc 2101 gtggcaggca tcgtgctgat cggcattctc ctgctggtca tctggaaggc tctgatccac 2161 ctgagcgacc tccgggagta caggcgcttt gagaaggaga agctcaagtc ccagtggaac 2221 aatgataatc cccttttcaa gagcgccacc acgacggtca tgaaccccaa gtttgctgag 2281 agttaggagc a

(2) INFORMATION FOR SEQ ID NO: 2576: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 661 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2576:

1 tcttcctctc ctgggccgtc ctctgagcag cagacggggc taagcgttcc ccagctcgcc

61 ttcacacaca gcccgtgcca ccacaccgac ggtaccatga aggacgaggt agctctactg

121 gctgctgtca ccctcctggg agtcctgctg caagcctact tctccctgca ggtgatctcg

181 gcgcgcaggg ccttccgcgt gtcgccgccg ctcaccaccg gcccacccga gttcgagcgc

241 gtctaccgag cccaggtgaa ctgcagcgag tacttcccgc tgttcctcgc cacgctctgg

301 gtcgccggca tcttctttca tgaaggggcg gcggccctgt gcggcctggt ctacctgttc

361 gcgcgcctcc gctacttcca gggctacgcg cgctccgcgc agctcaggct ggcaccgctg

421 tacgcgagcg cgcgcgccct ctggctgctg gtggcgctgg ctgcgctcgg cctgctcgcc

481 cacttcctcc cggccgcgct gcgcgccgcg ctcctcggac ggctccggac gctgctgccg

541 tgggcctgag accaaggccc ccgggccgac ggagccggga aagaagagcc ggagcctcca

601 gctgccccgg ggaggggcgc tcgcttccgc atcctagtct ctatcattaa agttctagtg 661 accga

(2) INFORMATION FOR SEQ ID NO:2577: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4441 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2577:

1 gagctcacag agcccccagc tggggcatat ctggtttccg ggggcagggg cgatacccag

61 aggaggaaga agggattctg agagagccca acaggctccg agcctcaggc tggagctgag

121 cttggggcag caaggaagga ccaggtgcga gggcagaacc atgcggcccg acccctgcag

181 cacggcctgt ggcctccccc agctcctgcc cgtgcttctg ggtcagtctg gactttgcca

241 cttctgacca aaagccaccg caaacccact caagccaaaa gaggaagtga ccgttaggcc

301 caactgggaa ggctggcggc caggggcact ccaggcaggg cgaggggggc ggccgggggc

361 gctccaggcg gggcgaggga gacacccaga actccaggca ggagtcctcg ggtgccacct

421 ttcctctcca cctggccctg cgtgggctct gtcctcaggg tggcccgccg tagtccccct

481 ccccactctg agtttcctgt cccaaagtcc taaggaagtt tccagaacta catctcacca

541 tcttgagtca gccttggctc agtgtccatc tcacaggcct ggaaggggca ggagtcagca

601 ■ ctgtccagac cacagggcct gagtgtgggg agggcagccg tctaggaagg tggtggaggg

661 ttgttacctt gaggcaagag ggctgcgggg cagaaagaca cagcaggtga ctgttgtggg

721 aggcccaaga gaggcctggg agagggatgg cccacaaggg ctgaccctcc cgccacccag

781 ggggccttgg acaggtttcc tcctggcagg gtggcccttg tgcatggaac ccctacaacg

841 actaaggctg gcaggcatga ggtttcctga aggagaaaga gcttgtgggg cccagtgtgg

901 ctgggggggc gctgggactc cattctgaag ccaaaggcac tgggaagggc ttccgcagag

961 gagggtttgg caggggttgc caggaacagc ctggatgggg acagggaaca gataaggtgg

1021 gtggaggagt tagccgggag cctggggctg gctccagcat gatgtggggg tctgcaaggc

1081 cctggagaaa gtggggtggt gcagcagggg gcacacccac agctggagct gacccagatg EPI-109 754

1141 gacagcttgg gctctgccac gcgggactag gcaaggaagg ggcacgaaca agcaggaagt

1201 ggtgaggcgg tctccagcta gctgctctcc cctgcccaga ctttggtttc ctccctgctg

1261 gcttggcctg gctccctggc tctgtgtggt atggtcacac ccccgtgcac cccctccact

1321 gagatggggc ggggagagca ccgaggctgc tcttcctctc ctgggccgtc ctctgagcag

1381 cagacggggc taagcgttcc ccagctcgcc ttcacacaca gcccσtgcca ccacaccgac

1441 ggtaccatga aggacgaggt agctctactg gctgctgtca ccctcctggg agtcctgctg

1501 caaggtgggc tggttcctat ctaggaagag ggtgggcctt agatccctac agcttgccct

1561 ctgcccccta ggcccaggtg gagggcagag gtggggactc cagcccaggc ccaagctgga

1621 agagggtggg gactttcagg gaactggggg gcacctggct gtgagagctg taggacttgg

1681 gggtggcaag ggtgccagga caaatggtag gatagccatg ggcttgggga agctgatctc

1741 tgctctttcc agctgtcccc tctctgggcg tcccagcaag cggcccecat tccctggctc

1801 tgcttcaaag gcacctccat actgggacca cgtggagcag ggtagaggtg ggactccttc

1861 ctccagcccc ctaaaaagag cctgcttaat gcctttctca gactggccct aaaggacaca

1921 ttccttggcc agatatcctt gccacctaag agacaccact actccacagt gtgtgggcta

1981 ggataaggca cagcctgggg agggggctct gaaggggctg aacagacagg ccagcctgac

2041 ctccagctgc tcctgcactg agctggatgg ccaccctgtg acacccatct gcagagggcc

2101 cagaaccaaa ggtgccaggg ctgcaggact cagggggaga tggtccgacg ggaggtctgg

2161 ggagggagcg cacagccagc actggtctgt gtgtggtctg gcctggcctc acctgaccaa

2221 gagaagggct cctgcccaca gagaaacttt agggccagcc caccctctgc aactacccca

2281 gccctggggt cctggggtta ggctaggaga gtcccagctg caacctcctg ggagcaggag

2341 agaaggtgtc tgtcagattt aggcctggga ccggaatgca ggaacagaga aactgaggtt

2401 tggaggcaca gggacgcagg ctttagtgat cccggcctga ggcagggtca gagggccctg

2461 ctggtgggcg ctggtaggtg ggtgaccagg gactgttagc tacagggagt gtgcttcctt

2521 gcacctggga ggatgcagcc agctctgccc tcagactccc gaggcacttc ctggccaggg

2581 acctgaaagc tgcatttgcc tgtgttttga gagtgaaatg attcagaaac aaggactcaa

2641 gtggtctctc tcgcggagca ggtgtccctg tgcctgaatc actcaccctc ccccatacac

2701 tcacaggttg ggacagggcc tctctgcgcc ccaggcttca gccctgccct cctcgctgaa

2761 tgtcagggac acagggcagg ccagggatgg gtgagacgag aggtctcctc gggcggggag

2821 ggggcggggt tccgccttag ggaggagagg acacggccaa gtgaagggcc agattgcagg

2881 atccctccca ctcccatctc tggggcttcg ggtgtccaga cctgactccc gctccccctc

2941 ctcccccagc ctacttctcc ctgcaggtga tctcggcgcg cagggccttc cgcgtgtcgc

3001 cgccgctcac caccggccca cccgagttcg agcgcgtcta ccgagcccag tgaggcgcgg

3061 cgggagggcg cggggcgggg agcgagcccc aggcgggtcc gggtcgcagg accatcccgg

3121 ccggcgcgct catcccaccc gcccaccgca gggtgaactg cagcgagtac ttcccgctgt

3181 tcctcgccac gctctgggtc gccggcatct tctttcatga aggtcggggt gtggggcagg

3241 ggcgcacgcg ctggaccccc gggacccgcg cagggcgctc accaggcccg tgcgtacctc

3301 tcgcaggggc ggcggccctg tgcggcctgg tctacctgtt cgcgcgcctc cgctacttcc

3361 agggctacgc gcgctccgcg cagctcaggt gagggccggg cggggagcgg ggcggggccg

3421 gggaaagatc gcgggcgggc ggggctcctg gggagcggga ccgaagctgg gggcgggcga

3481 cgggccggag cccagcgcct ttggggattc ggtgggcgag ccctggcggc ggccagagga

3541 agtccccgtg gggccagggt tgcggcgggg aagaagcggg cctcctcgcg ccacctcccc

3601 gctgaccgcc gcccgcaggc tggcaccgct gtacgcgagc gcgcgcgccc tctggctgct

3661 ggtggcgctg gctgcgctcg gcctgctcgc ccacttcctc ccggccgcgc tgcgcgccgc

3721 gctcctcgga cggctccgga cgctgctgcc gtgggcctga gaccaaggcc cccgggccga

3781 cggagccggg aaagaagagc cggagcctcc agctgccccg gggaggggcg ctcgcttccg

3841 catcctagtc tctatcatta aagttctagt gaccgagacc cgggctgcgt tctctgggtc

3901 cgcgggggtg gcgcaccgcg ggctacggag cctggagggg cccagcccga gtccgggcag

3961 cccggggcgg gcttcctagt ggcggcgtga gagtggctgc gaaggaacga gccctccccc

4021 tggggcggga ctggatccgg tcttcacctc ctaccccact ccctactcag cctcggggtc

4081 acaaggccgc ccagtcctgc cggggttcac cctcctagcg ctcagcggtc tcctcaccgg

4141 tccccctcct caggggcctt ccctcgactc tcagccgccg cagtccctcg tcccctggcc

4201 ttcacagctg acactagata gagcctgtgg ctctctcccc aggtgagggc aggggttttt

4261 cttttggtca gcactggatc cccctcgtta actgtaggtg ttcagggcag ccctccgagg

4321 tccgcagagc tgcgggcacc atgggaacga agtgagtcag tgacaggcgg tctcaaggaa

4381 atgtccagaa gccttgggga tccaggggag gcccacagaa acaaagaagt gacttttagc 4441 caagtatgca ggagaaacgg aggag

(2) INFORMATION FOR SEQ ID NO: 2578: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 5102 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2578:

1 tcttcctctc ctgggccgtc ctctgagcag cagacggggc taagcgttcc ccagctcgcc

61 ttcacacaca gcccgtgcca ccacaccgac ggtaccatga aggacgaggt agctctactg

121 gctgctgtca ccctcctggg agtcctgctg caagcctact tctccctgca ggtgatctcg

181 gcgcgcaggg ccttccgcgt gtcgccgccg ctcaccaccg gcccacccga gttcgagcgc

241 gtctaccgag cccaggtgaa ctgcagcgag tacttcccgc tgttcctcgc cacgctctgg EPI-109 755

301 gtcgccggca tcttctttca tgaaggggcg gcggccctgt gcggcctggt ctacctgttc 361 gcgcgcctcc gctacttcca gggctacgcg cgctccgcgc agctcaggct ggcaccgctg 421 tacgcgagcg cgcgcgccct ctggctgctg gtggcgctgg ctgcgctcgg cctgctcgcc 481 cacttcctcc cggccgcgct gcgcgccgcg ctcctcggac ggctccggac gctgctgccg 541 tgggcctgag accaaggccc ccgggccgac ggagccggga aagaagagcc ggagcctcca 601 gctgccccgg ggaggggcgc tcgcttccgc atcctagtct ctatcattaa agttctagtg 661 accga

1 gagctcacag agcccccagc tggggcatat ctggtttccg ggggcagggg cgatacccag

61 aggaggaaga agggattctg agagagccca acaggctccg agcctcaggc tggagctgag

121 cttggggcag caaggaagga ccaggtgcga gggcagaacc atgcggcccg acccctgcag

181 cacggcctgt ggcctccccc agctcctgcc cgtgcttctg ggtcagtctg gactttgcca

241 cttctgacca aaagccaccg caaacccact caagccaaaa gaggaagtga ccgttaggcc

301 caactgggaa ggctggcggc caggggcact ccaggcaggg cgaggggggc ggccgggggc

361 gctccaggcg gggcgaggga gacacccaga actccaggca ggagtcctcg ggtgccacct

421 ttcctctcca cctggccctg cgtgggctct gtcctcaggg tggcccgccg tagtccccct

481 ccccactctg agtttcctgt cccaaagtcc taaggaagtt tccagaacta catctcacca

541 tcttgagtca gccttggctc agtgtccatc tcacaggcct ggaaggggca ggagtcagca

601 ctgtccagac cacagggcct gagtgtgggg agggcagccg tctaggaagg tggtggaggg

661 ttgttacctt gaggcaagag ggctgcgggg cagaaagaca cagcaggtga ctgttgtggg

721 aggcccaaga gaggcctggg agagggatgg cccacaaggg ctgaccctcc cgccacccag

781 ggggccttgg acaggtttcc tcctggcagg gtggcccttg tgcatggaac ccctacaacg

841 actaaggctg gcaggcatga ggtttcctga aggagaaaga gcttgtgggg cccagtgtgg

901 ctgggggggc gctgggactc cattctgaag ccaaaggcac tgggaagggc ttccgcagag

961 gagggtttgg caggggttgc caggaacagc ctggatgggg acagggaaca gataaggtgg

1021 gtggaggagt tagccgggag cctggggctg gctccagcat gatgtggggg tctgcaaggc

1081 cctggagaaa gtggggtggt gcagcagggg gcacacccac agctggagct gacccagatg

1141 gacagcttgg gctctgccac gcgggactag gcaaggaagg ggcacgaaca agcaggaagt

1201 ggtgaggcgg tctccagcta gctgctctcc cctgcccaga ctttggtttc ctccctgctg

1261 gcttggcctg gctccctggc tctgtgtggt atggtcacac ccccgtgcac cccctccact

1321 gagatggggc ggggagagca ccgaggctgc tcttcctctc ctgggccgtc ctctgagcag

1381 cagacggggc taagcgttcc ccagctcgcc ttcacacaca gcccgtgcca ccacaccgac

1441 ggtaccatga aggacgaggt agctctactg gctgctgtca ccctcctggg agtcctgctg

1501 caaggtgggc tggttcctat ctaggaagag ggtgggcctt agatccctac agcttgccct

1561 ctgcccccta ggcccaggtg gagggcagag gtggggactc cagcccaggc ccaagctgga

1621 agagggtggg gactttcagg gaactggggg gcacctggct gtgagagctg taggacttgg

1681 gggtggcaag ggtgccagga caaatggtag gatagccatg ggcttgggga agctgatctc

1741 tgctctttcc agctgtcccc tctctgggcg tcccagcaag cggcccccat tccctggctc

1801 tgcttcaaag gcacctccat actgggacca cgtggagcag ggtagaggtg ggactccttc

1861 ctccagcccc ctaaaaagag cctgcttaat gcctttctca gactggccct aaaggacaca

1921 ttccttggcc agatatcctt gccacctaag agacaccact actccacagt gtgtgggcta

1981 ggataaggca cagcctgggg agggggctct gaaggggctg aacagacagg ccagcctgac

2041 ctccagctgc tcctgcactg agctggatgg ccaccctgtg acacccatct gcagagggcc

2101 cagaaccaaa ggtgccaggg ctgcaggact cagggggaga tggtccgacg ggaggtctgg

2161 ggagggagcg cacagccagc actggtctgt gtgtggtctg gcctggcctc acctgaccaa

2221 gagaagggct cctgcccaca gagaaacttt agggccagcc caccctctgc aactacccca

2281 gccctggggt cctggggtta ggctaggaga gtcccagctg caacctcctg ggagcaggag

2341 agaaggtgtc tgtcagattt aggcctggga ccggaatgca ggaacagaga aactgaggtt

2401 tggaggcaca gggacgcagg ctttagtgat cccggcctga ggcagggtca gagggccctg

2461 ctggtgggcg ctggtaggtg ggtgaccagg gactgttagc tacagggagt gtgcttcctt

2521 gcacctggga ggatgcagcc agctctgccc tcagactccc gaggcacttc ctggccaggg

2581 acctgaaagc tgcatttgcc tgtgttttga gagtgaaatg attcagaaac aaggactcaa

2641 gtggtctctc tcgcggagca ggtgtccctg tgcctgaatc actcaccctc ccccatacac

2701 tcacaggttg ggacagggcc tctctgcgcc ccaggcttca gccctgccct cctcgctgaa

2761 tgtcagggac acagggcagg ccagggatgg gtgagacgag aggtctcctc gggcggggag

2821 ggggcggggt tccgccttag ggaggagagg acacggccaa gtgaagggcc agattgcagg

2881 atccctccca ctcccatct^'c tggggcttcg ggtgtccaga cctgactccc gctccccctc

2941 ctcccccagc ctacttctcc ctgcaggtga tctcggcgcg cagggccttc cgcgtgtcgc

3001 cgccgctcac caccggccca cccgagttcg agcgcgtcta ccgagcccag tgaggcgcgg

3061 cgggagggcg cggggcgggg agcgagcccc aggcgggtcc gggtcgcagg accatcccgg

3121 ccggcgcgct catcccaccc gcccaccgca gggtgaactg cagcgagtac ttcccgctgt

3181 tcctcgccac gctctgggtc gccggcatct tctttcatga aggtcggggt gtggggcagg

3241 ggcgcacgcg ctggaccccc gggacccgcg cagggcgctc accaggcccg tgcgtacctc

3301 tcgcaggggc ggcggccctg tgcggcctgg tctacctgtt cgcgcgcctc cgctacttcc

3361 agggctacgc gcgctccgcg cagctcaggt gagggccggg cggggagcgg ggcggggccg

3421 gggaaagatc gcgggcgggc ggggctcctg gggagcggga ccgaagctgg gggcgggcga

3481 cgggccggag cccagcgcct ttggggattc ggtgggcgag ccctggcggc ggccagagga

3541 agtccccgtg gggccagggt tgcggcgggg aagaagcggg cctcctcgcg ccacctcccc

3601 gctgaccgcc gcccgcaggc tggcaccgct gtacgcgagc gcgcgcgccc tctggctgct EPI-109 756

3661 ggtggcgctg gctgcgctcg gcctgctcgc ccacttcctc ccggccgcgc tgcgcgccgc

3721 gctcctcgga cggctccgga cgctgctgcc gtgggcctga gaccaaggcc cccgggccga

3781 cggagccggg aaagaagagc cggagcctcc agctgccccg gggaggggcg ctcgcttccg

3841 catcctagtc tctatcatta aagttctagt gaccgagacc cgggctgcgt tctctgggtc

3901 cgcgggggtg gcgcaccgcg ggctacggag cctggagggg cccagcccga gtccgggcag

3961 cccggggcgg gcttcctagt ggcggcgtga gagtggctgc gaaggaacga gccctccccc

4021 tggggcggga ctggatccgg tcttcacctc ctaccccact ccctactcag cctcggggtc

4081 acaaggccgc ccagtcctgc cggggttcac cctcctagcg ctcagcggtc tcctcaccgg

4141 tccccctcct caggggcctt ccctcgactc tcagccgccg cagtccctcg tcccctggcc

4201 ttcacagctg acactagata gagcctgtgg ctctctcccc aggtgagggc aggggttttt

4261 cttttggtca gcactggatc cccctcgtta actgtaggtg ttcagggcag ccctccgagg

4321 tccgcagagc tgcgggcacc atgggaacga agtgagtcag tgacaggcgg tctcaaggaa

4381 atgtccagaa gccttgggga tccaggggag gcccacagaa acaaagaagt gacttttagc

4441 caagtatgca ggagaaacgg aggag

(2) INFORMATION FOR SEQ ID NO: 2579: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3001 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2579:

1 gccattctct cacatcccgt gcggtcagga agcccttcct gaactctgac ttcagttctt

61 gctgcggttt ctgcccattt ttttcatatc ctctgacagc tgcgaggtca tctctgctct

121 ggcttttctc caagcaσaac aagtgggggc tctggaaagg ttaagggacc tcagtggcca

181 ccattatact ttgcatcttt cctgagaagt gagagttgaa agggaagcag gaaggcccat

241 ggtcagattg aaggaaggac tttttagttt cttttttttt tttttgaaat ggagtctcgc

301 tctgtcattc aggctggagt gcagtggtgc gatctcagct cactgcagcc tccacttcct

361 gggttcacat gattctcctg cctcagcctc ccaagtagct gagactacag gcacatgcca

421 ctacacccag ctaacttttg tatttttagt agagacgggg tttcaccatg ttggccaggc

481 tggtctcaaa ctgctaacat caagtgatct gctcccctca gcctcccaaa gtgctgggat

541 taccggtatg aaccaccaca acctgccagg aatttttagt ttttagcttt tgcaggagac

601 ttcaaggaaa ggagacattc ctctgtccag gaaacgggta aggggaccat ttctgcattg

661 ctggtttccc ctcttggcag ggtgggcatg aggcatcact gttcctgctc cctcactcct

721 gctcctcatg ctcagcctgc cagctcggcc tcaactttgt gtgtctaaag tggaactgaa

781 tagtagctgt gagaagatag gaaagaggta gtgccaatct ccttgcccag atcataaatc

841 cagactcagc agggtaacca catgggcaag cacaaggtag gtgcttgggg aaaggggaag

901 taattggcat tctgtgtgat accaaggaga ccatttggat tttggcttct accaaagaga

961 atggagaatt ggttgaccta aatggaacca gtccctttaa gtaaggggag gaaagggggt

1021 gctggaagat ggccctcttc ccaccaccta gatcatagct tgaactgaag ccaaggacag

1081 agtgctgccc ccttcggcat ttactgatgt gccctcttta aatcatgatg ttatctaacc

1141 caaacccaga cccaggacct agtcacagct ccaacctaca cttcctatta atcttaaaac

1201 aaagcgaaac aaacacaaaa agatatcagc attgtagcct ccaatctgag cccatttccc

1261 ttctctggct accatacctc cttctcctat atgataccat tcactacttt gttcaattat

1321 ccagtctaga cctgcatctt gaggccacac ccagccttct cactccccac acccctcttt

1381 cctctctcac tgctccttcc tggtctcttc tcatctggcc ccacctctaa ggagtcctcc

1441 tgccttctgg gttgccctgg aaaacagact atcccccctc ctagtgaagg gagtgggtag

1501 gggtttcagc cccaccctca ggaagatgcg tcttccctgt cctctgctct gtggtacttc

1561 ctctctggct gatttagcaa acagcaccta gacctggggc caggcctttg gcagtgggac

1621 agatccaggg ataggctaca ccaccctgcc ctgaccctgg gattggcatc agcttccaac

1681 cagttcctgc caaagcttgt aagtcctccc gacggccatg aacactacat cttctgcagc

1741 acccccctca ctaggtgtag agttcatctc tctgctggct atcatcctgc tgtcagtggc

1801 gctggctgtg gggcttcccg gcaacagctt tgtggtgtgg agtatcctga aaaggatgca

1861 gaagcgctct gtcactgccc tgatggtgct gaacctggcc ctggccgacc tggccgtatt

1921 gctcactgct ccctttttcc ttcacttcct ggcccaaggc acctggagtt ttggactggc

1981 tggttgccgc ctgtgtcact atgtctgcgg agtcagcatg tacgccagcg tcctgcttat

2041 cacggccatg agtctagacc gctcactggc ggtggcccgc ccctttgtgt cccagaagct

2101 acgcaccaag gcgatggccc ggcgggtgct ggcaggcatc tgggtgttgt cctttctgct

2161 ggccacaccc gtcctcgcgt accgcacagt agtgccctgg aaaacgaaca tgagcctgtg

2221 cttcccgcgg taccccagcg aagggcaccg ggccttccat ctaatcttcg aggctgtcac

2281 gggcttcctg ctgcccttcc tggctgtggt ggccagctac tcggacatag ggcgtcggct

2341 acaggcccgg cgcttccgcc gcagccgccg caccggccgc ctggtggtgc tcatcatcct

2401 gaccttcgcc gccttctggc tgccctacca cgtggtgaac ctggctgagg cgggccgcgc

2461 gctggccggc caggccgccg ggttagggct cgtggggaag cggctgagcc tggcccgcaa

2521 cgtgctcatc gcactcgcct tcctgagcag cagcgtgaac cccgtgctgt acgcgtgcgc

2581 cggcggcggc ctgctgcgct cggcgggcgt gggcttcgtc gccaagctgc tggagggcac

2641 gggttccgag gcgtccagca cgcgccgcgg gggcagcctg ggccagaccg ctaggagcgg

2701 ccccgccgct ctggagcccg gcccttccga gagcctcact gcctccagcc ctctcaagtt

2761 aaacgaactg aactaggcct ggtggaagga ggcgcacttt cctcctggca gaatgctagc EPI-109 757

2821 tctgagccag ttcagtacct ggaggaggag caggggcgtg gagggcgtgg agggcgtggg 2881 agcgtgggag gcgggagtgg agtggaagaa gagggagaga tggagcaaag tgagggccga 2941 gtgagagcgt gctccagcct ggctcccaca ggcagcttta accattaaaa ctgaagtctg 3001 aa

(2) INFORMATION FOR SEQ ID NO: 2580: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 841 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2580:

1 aaaagaagga cctgggcttt gggaagatct aaagacccag gaaggtctct gggtgggata 61 aagccaagat gaaactcccc ctacttctgg ctcttctatt tggggcagtt tctgctcttc 121 atctaaggtc tgagacttcc acctttgaga cccctttggg tgctaagacg ctgcctgagg 181 atgaggagac accagagcag gagatggagg agaccccttg cagggagctg gaggaagagg 241 aggagtgggg ctctggaagt gaagatgcct ccaagaaaga tggggctgtt gagtctatct 301 cagtgccaga tatggtgcac aaaaacctta cgtgtcctga ggaagaggac acagtaaaag 361 tggtgggcat ccctgggtgc cagacctgcc gctacctcct ggtgagaagt cttcagacgt 421 ttagtcaagc ttggtttact tgccggaggt gctacagggg caacctggtt tccatccaca 481 acttcaatat taattatcga atccagtgtt ctgtcagcgc gctcaaccag ggtcaagtct 541 ggattggagg caggatcaca ggctcgggtc gctgcagacg ctttcagtgg gttgacggca 601 gccgctggaa ctttgcgtac tgggctgctc accagccctg gtcccgcggt ggtcactgcg 661 tggccctgtg tacccgagga ggctactggc gtcgagccca ctgcctcaga agacttcctt 721 tcatctgttc ctactgagct ggtcccagcc agcagttcaσ agctgccctc tcctgggcag 781 ctgcctcccc tcctctgctt gccatccctc cctccacctc cctgcaataa aatgggtttt 841 actgaaaa

(2) INFORMATION FOR SEQ ID NO:2581: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 841 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO 2581:

1 aaaagaagga cctgggcttt gggaagatct aaagacccag gaaggtctct gggtgggata

61 aagccaagat gaaactcccc ctacttctgg ctcttctatt tggggcagtt tctgctcttc

121 atctaaggtc tgagacttcc acctttgaga cccctttggg tgctaagacg ctgcctgagg

181 atgaggagac accagagcag gagatggagg agaccccttg cagggagctg gaggaagagg

241 aggagtgggg ctctggaagt gaagatgcct ccaagaaaga tggggctgtt gagtctatct

301 cagtgccaga tatggtggac aaaaacctta cgtgtcctga ggaagaggac acagtaaaag

361 tggtgggcat ccctgggtgc cagacctgcc gctacctcct ggtgagaagt cttcagacgt

421 ttagtcaagc ttggtttact tgccggaggt gctacagggg caacctggtt tccatccaca

481 acttcaatat taattatcga atccagtgtt ctgtcagcgc gctcaaccag ggtcaagtct

541 ggattggagg caggatcaca ggctcgggtc gctgcagacg ctttcagtgg gttgacggca

601 gccgctggaa ctttgcgtac tgggctgctc accagccctg gtcccgcggt ggtcactgcg

661 tggccctgtg tacccgagga ggctactggc gtcgagccca ctgcctcaga agacttcctt

721 tcatctgttc ctactgagct ggtcccagcc agcagttcag agctgccctc tcctgggcag 781 ctgcctcccc tcctctgctt gccatccctc cctccacctc cctgcaataa aatgggtttt

841 actgaaaa

(2) INFORMATION FOR SEQ ID NO: 2582: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1682 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2582

1 aaaagaagga cctgggcttt gggaagatct aaagacccag gaaggtctct gggtgggata 61 aagccaagat gaaactcccc ctacttctgg ctcttctatt tggggcagtt tctgctcttc 121 atctaaggtc tgagacttcc acctttgaga cccctttggg tgctaagacg ctgcctgagg 181 atgaggagac accagagcag gagatggagg agaccccttg cagggagctg gaggaagagg 241 aggagtgggg ctctggaagt gaagatgcct ccaagaaaga tggggctgtt gagtctatct 301 cagtgccaga tatggtgcac aaaaacctta cgtgtcctga ggaagaggac acagtaaaag 361 tggtgggcat ccctgggtgc cagacctgcc gctacctcct ggtgagaagt cttcagacgt 421 ttagtcaagc ttggtttact tgccggaggt gctacagggg caacctggtt tccatccaca 481 acttcaatat taattatcga atccagtgtt ctgtcagcgc gctcaaccag ggtcaagtct 541 ggattggagg caggatcaca ggctcgggtc gctgcagacg ctttcagtgg gttgacggca 601 gccgctggaa ctttgcgtac tgggctgctc accagccctg gtcccgcggt ggtcactgcg 661 tggccctgtg tacccgagga ggctactggc gtcgagccca ctgcctcaga agacttcctt EPI-109 758

721 tcatctgttc ctactgagct ggtcccagcc agcagttcag agctgccctc tcctgggcag

781 ctgcctcccc tcctctgctt gccatccctc cctccacctc cctgcaataa aatgggtttt

841 actgaaaa

1 aaaagaagga cctgggcttt gggaagatct aaagacccag gaaggtctct gggtgggata

61 aagccaagat gaaactcccc ctacttctgg ctcttctatt tggggcagtt tctgctcttc

121 atctaaggtc tgagacttcc acctttgaga cccctttggg tgctaagacg ctgcctgagg

181 atgaggagac accagagcag gagatggagg agaccccttg cagggagctg gaggaagagg

241 aggagtgggg ctctggaagt gaagatgcct ccaagaaaga tggggctgtt gagtctatct

301 cagtgccaga tatggtggac aaaaacctta cgtgtcctga ggaagaggac acagtaaaag

361 tggtgggcat ccctgggtgc cagacctgcc gctacctcct ggtgagaagt cttcagacgt

4 421 ttagtcaagc ttggtttact tgccggaggt gctacagggg caacctggtt tccatccaca

481 acttcaatat taattatcga atccagtgtt ctgtcagcgc gctcaaccag ggtcaagtct

541 ggattggagg caggatcaca ggctcgggtc gctgcagacg ctttcagtgg gttgacggca

601 gccgctggaa ctttgcgtac tgggctgctc accagccctg gtcccgcggt ggtcactgcg

661 tggccctgtg tacccgagga ggctactggc gtcgagccca ctgcctcaga agacttcctt

721 tcatctgttc ctactgagct ggtcccagcc agcagttcag agctgccctc tcctgggcag

781 ctgcctcccc tcctctgctt gccatccctc cctccacctc cctgcaataa aatgggtttt

841 actgaaaa

(2) INFORMATION FOR SEQ ID NO: 2583: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 781 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2583 1 agcagagggg ctgagaccaa accagaaacc tccaattctc atgtggaagc ccatgccctc

61 accctccaac atgaaagcct ctgcagcact tctgtgtctg ctgctcacag cagctgcttt

121 cagcccccag gggcttgctc agccagttgg gattaatact tcaactacct gctgctacag

181 atttatcaat aagaaaatcc ctaagcagag gctggagagc tacagaagga ccaccagtag

241 ccactgtccc cgggaagctg taatcttcaa gaccaaactg gacaaggaga tctgtgctga

301 ccccacacag aagtgggtcc aggactttat gaagcacctg gacaagaaaa cccaaactcc

361 aaagctttga acattcatga ctgaactaaa aacaagccat gacttgagaa acaaataatt

421 tgtataccct gtcctttctc agagtggttc tgagattatt ttaatctaat tctaaggaat

481 atgagcttta tgtaataatg tgaatcatgg tttttcttag tagattttaa aagttattaa

541 tattttaatt taatcttcca tggattttgg tgggttttga acataaagcc ttggatgtat

601 atgtcatctc agtgctgtaa aaactgtggg atgctcctcc cttctctacc tcatgggggt

661 attgtataag tccttgcaag aatcagtgca aagatttgct ttaattgtta agatatgatg

721 tccctatgga agcatattgt tattatataa ttacatattt gcatatgtat gactcccaaa 781 ttttcacata aaatagattt ttgtaaaaaa

(2) INFORMATION FOR SEQ ID NO: 2584: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1081 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2584 1 ggtttctatt gacttgggtt aatcgtgtga ccgcggtggc tggcacgaaa ttgaccaacc

61 ctggggttag tatagcttag ttaaactttc gtttattgct aaaggttaat cactgctgtt

121 tcccgtgggg gtgtggctag gctaagcgtt ttgagctgca ttgctgcgtg cttgatgctt

181 gtcccttttg atcgtggtga tttagagggt gaactcactg gaatggggat gcttgcatgt

241 gtaatcttac taagagctaa tagaaaggct aggaccaaac cagaaacctc caattctcat

301 gtggaagccc atgccctcac cctccaacat gaaagcctct gcagcacttc tgtgtctgct

361 gctcacagca gctgctttca gcccccaggg gcttgctcag ccagttggga ttaatacttc

421 aactacctgc tgctacagat ttatcaataa gaaaatccct aagcagaggc tggagagcta

481 cagaaggacc accagtagcc actgtccccg ggaagctgta atcttcaaga ccaaactgga

541 caaggagatc tgtgctgacc ccacacagaa gtgggtccag gactttatga agcacctgga

601 caagaaaacc caaactccaa agctttgaac attcatgact gaactgaaaa caagccatga

661 cttgagaaac aaataatttg tataccctgt cctttctcag agtggttctg agattatttt

721' aatctaattc taaggaatat gagctttatg taataatgtg aatcatggtt tttcttagta

781 gattttaaaa gttattaata ttttaattta atcttccatg gattttggtg ggttttgaac

841 ataaagcctt ggatgtatat gtcatctcag tgctgtaaaa actgtgggat gctcctccct

901 tctctacctc atgggggtat tgtataagtc cttgcaagaa tcagtgcaaa gatttgcttt

961 aattgttaag atatgatgtc cctatggaag catattgtta ttatataatt acatatttgc

1021 atatgtatga ctcccaaatt ttcacataaa atagattttt gtataacaaa aaaaaaaaaa

1081 aaaaa

(2) INFORMATION FOR SEQ ID NO: 2585: (i) SEQUENCE CHARACTERISTICS: EPI-109 759

(A) LENGTH: 1081 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2585

1 ggtttctatt gacttgggtt aatcgtgtga ccgcggtggc tggcacgaaa ttgaccaacc

61 ctggggttag tatagcttag ttaaactttc gtttattgct aaaggttaat cactgctgtt

121 tcccgtgggg gtgtggctag gctaagcgtt ttgagctgca ttgctgcgtg cttgatgctt

181 gtcccttttg atcgtggtga tttagagggt gaactcactg gaatggggat gcttgcatgt

241 gtaatcttac taagagctaa tagaaaggct aggaccaaac cagaaacctc caattctcat

301 gtggaagccc atgccctcac cctccaacat gaaagcctct gcagcacttc tgtgtctgct

361 gctcacagca gctgctttca gcccccaggg gcttgctcag ccagttggga ttaatacttc

421 aactacctgc tgctacagat ttatcaataa gaaaatccct aagcagaggc tggagagcta

481 cagaaggacc accagtagcc actgtccccg ggaagctgta atcttcaaga ccaaactgga

541 caaggagatc tgtgctgacc ccacacagaa gtgggtccag gactttatga agcacctgga

601 caagaaaacc caaactccaa agctttgaac attcatgact gaactgaaaa caagccatga

661 cttgagaaac aaataatttg tataccctgt cctttctcag agtggttctg agattatttt

721 aatctaattc taaggaatat gagctttatg taataatgtg aatcatggtt tttcttagta

781 gattttaaaa gttattaata ttttaattta atcttccatg gattttggtg ggttttgaac

841 ataaagcctt ggatgtatat gtcatctcag tgctgtaaaa actgtgggat gctcctccct

901 tctctacctc atgggggtat tgtataagtc cttgcaagaa tcagtgcaaa gatttgcttt

961 aattgttaag atatgatgtc cctatggaag catattgtta ttatataatt acatatttgc

1021 atatgtatga ctcccaaatt ttcacataaa atagattttt gtataacaaa aaaaaaaaaa

1081 aaaaa

(2) INFORMATION FOR SEQ ID NO:2586: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2881 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2586

1 ggatccttaa gccatcatgc aaaatatcta gccatgtgga gggaccactg gaaagatcac

61 acacacacac acacacacac acacacacac atacagagag agagagagac acctgagaaa

121 ttccatctgg tccaactgct ggctgttgaa gtcctcccag cccagacccc agacactgaa

181 tgaaggcctt gtgatatagt caagagcaaa aaaacccaga agattgttat tgttttaagt

241 cactgttttc agatagattg ctatgcagca atagattatt gaaatagaca ctacaatttt

301 aggtactatt attctaagaa tattgaattt tatttttctg ctaatgttct attattttac

361 ttttctctgg gttttagaaa gccaccagga tttaagacag tgaagaatct ttgagtcctt

421 tgtagagttg aaccaaagtt tgaatgtctc tttgtggact cgtgtcctag ggataccact

481 ccaaagggaa aaggggaata tcccttacat atctttgact ttggtatccc tgattccttc

541 ctttttctat agaatgtgtc tcatttcaga gaaactggtc tcttgataat agccatagat

601 tacatactgt ggtcttcctc tacatagacc ctacctcacc taccactcct ggtcttagct

661 gaaaaacagg ctagcctcga ctcatactgt catttcctat cctcccactg aagtgcactg

721 gctcagcaga tttattactc catagattta ttactccatt ctatgattca tcctctctgc

781 ttcctataaa aggcagagac agagcttcca gaggagcaga ggggctgaga ccaaaccaga

841 aacctccaat tctcatgtgg aagcccatgc cctcaccctc caacatgaaa gcctctgcag

901 cacttctgtg tctgctgctc acagcagctg ctttcagccc ccaggggctt gctcagccag

961 gtaaggtccc tctctccttc tccttgaagc acattgcccc ctctctgggt tatcctggac

1021 caatcaagaa gacctgatac ccacagtctc actttaacag ctacttttcc aagataaggt

1081 aacttagaaa aaggataagg ggtgagccca accacacagc tgctgttggg tagagcctga

1141 actagaattc cagctgtgaa ccccaaatcc agctccttct aggattccag ctctgggaac

1201 accctcagtg cagttaccac tccagctgct tccagcagaa tttgggatca gggtgatcaa

1261 agacaggagg cttctgggga tgggtgtgcg ggctgtttcc agataccggg agacccagaa

1321 tctggtctgt ggaagcccag cttccagaaa cagcagctct gcagaggtgg tacgtatcag

1381 ggaaactcat gaccaagcat tgaatgctca gagcctaaaa ggggatccat agttggggta

1441 cccttgctct aaggaattgg attattatat tagcccctcc tagcaatgcc cagagtagcc

1501 atcaattcct cttccgtctt tcaactggtg atggtgcatc cctatttcac agtccataaa

1561 agtgaaaggg agtttatgaa atgcctcaaa gggcagagac attgggtttg ggatgggcag

1621 cttttccctc cacctcttcc tttctttctg attccttctt cttaccattc cctgttttac

1681 aaacagaaag acccaggaca caccctcaat ggacttttct tcttgttgtt tcattgcagt

1741 tgggattaat acttcaacta cctgctgcta cagatttatc aataagaaaa tccctaagca

1801 gaggctggag agctacagaa ggaccaccag tagccactgt ccccgggaag ctgtaatgta

1861 tgtggacgat gaccacccac ccctcacacc tcagtcctag gttcttccct gggcagggaa

1921 taggactagt atcagaatga gttggagtca aatactgtga tgcatacagc atctctaacc

1981 ttatcccaga catttgccag tgagaaacaa tacaagtaaa gaaagtggct tctcactctc

2041 agctcccttt ccagctatca ttttacatct cagttcgttc cttcatcctg gaaccaagag

2101 agattcactt gggctaccaa aaagagctgc ttctctgagt ccccttcctt tgttttatct

2161 tcttccttca tccctgaggc atccccatca gctaggctga tgggctagac agatttccca EPI-109 760

2221 tagacttggt cacactccca ggctgaaccc tcaaggtgtt ccatctgact gtctcctttc

2281 tgctccacag cttcaagacc aaactggaca aggagatctg tgctgacccc acacagaagt

2341 gggtccagga ctttatgaag cacctggaca agaaaaccca aactccaaag ctttgaacat

2401 tcatgactga actgaaaaca agccatgact tgagaaacaa ataatttgta taccctgtcc

2461 tttctcagag tggttctgag attattttaa tctaattcta aggaatatga gctttatgta

2521 ataatgtgaa tcatggtttt tcttagtaga ttttaaaagt tattaatatt ttaatttaat

2581 cttccatgga ttttggtggg ttttgaacat aaagccttgg atgtatatgt catctcagtg

2641 ctgtaaaaac tgtgggatgc tcctcccttc tctacctcat gggggtattg tataagtcct

2701 tgcaagaatc agtgcaaaga tttgctttaa ttgttaagat atgatgtccc tatggaagca

2761 tattgttatt atataattac atatttgcat atgtatgact cccaaatttt cacataaaat

2821 agatttttgt ataacagctg ccattcatgg ttttttaaag gataagtaat aaagctggtg 2881 gggta

(2) INFORMATION FOR SEQ ID NO: 2587: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 5824 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2587

1 agcagagggg ctgagaccaa accagaaacc tccaattctc atgtggaagc ccatgccctc

61 accctccaac atgaaagcct ctgcagcact tctgtgtctg ctgctcacag cagctgcttt

121 cagcccccag gggcttgctc agccagttgg gattaatact tcaactacct gctgctacag

181 atttatcaat aagaaaatcc ctaagcagag gctggagagc tacagaagga ccaccagtag

241 ccactgtccc cgggaagctg taatcttcaa gaccaaactg gacaaggaga tctgtgctga

301 ccccacacag aagtgggtcc aggactttat gaagcacctg gacaagaaaa cccaaactcc

361 aaagctttga acattcatga ctgaactaaa aacaagccat gacttgagaa acaaataatt

421 tgtataccct gtcctttctc agagtggttc tgagattatt ttaatctaat tctaaggaat

481 atgagcttta tgtaataatg tgaatcatgg tttttcttag tagattttaa aagttattaa

541 tattttaatt taatcttcca tggattttgg tgggttttga acataaagcc ttggatgtat

601 atgtcatctc agtgctgtaa aaactgtggg atgctcctcc cttctctacc tcatgggggt

661 attgtataag tccttgcaag aatcagtgca aagatttgct ttaattgtta agatatgatg

721 tccctatgga agcatattgt tattatataa ttacatattt gcatatgtat gactcccaaa 781 ttttcacata aaatagattt ttgtaaaaaa

1 ggtttctatt gacttgggtt aatcgtgtga ccgcggtggc tggcacgaaa ttgaccaacc

61 ctggggttag tatagcttag ttaaactttc gtttattgct aaaggttaat cactgctgtt

121 tcccgtgggg gtgtggctag gctaagcgtt ttgagctgca ttgctgcgtg cttgatgctt

181 gtcccttttg atcgtggtga tttagagggt gaactcactg gaatggggat gcttgcatgt

241 gtaatcttac taagagctaa tagaaaggct aggaccaaac cagaaacctc caattctcat

301 gtggaagccc atgccctcac cctccaacat gaaagcctct gcagcacttc tgtgtctgct

361 gctcacagca gctgctttca gcccccaggg gcttgctcag ccagttggga ttaatacttc

421 aactacctgc tgctacagat ttatcaataa gaaaatccct aagcagaggc tggagagcta

481 cagaaggacc accagtagcc actgtccccg ggaagctgta atcttcaaga ccaaactgga

541 caaggagatc tgtgctgacc ccacacagaa gtgggtccag gactttatga agcacctgga

601 caagaaaacc caaactccaa agctttgaac attcatgact gaactgaaaa caagccatga

661 cttgagaaac aaataatttg tataccctgt cctttctcag agtggttctg agattatttt

721 aatctaattc taaggaatat gagctttatg taataatgtg aatcatggtt tttcttagta

781 gattttaaaa gttattaata ttttaattta atcttccatg gattttggtg ggttttgaac

841 ataaagcctt ggatgtatat gtcatctcag tgctgtaaaa actgtgggat gctcctccct

901 tctctacctc atgggggtat tgtataagtc cttgcaagaa tcagtgcaaa gatttgcttt

961 aattgttaag atatgatgtc cctatggaag catattgtta ttatataatt acatatttgc

1021 atatgtatga ctcccaaatt ttcacataaa atagattttt gtataacaaa aaaaaaaaaa

1081 aaaaa

1 ggtttctatt gacttgggtt aatcgtgtga ccgcggtggc tggcacgaaa ttgaccaacc

61 ctggggttag tatagcttag ttaaactttc gtttattgct aaaggttaat cactgctgtt

121 tcccgtgggg gtgtggctag gctaagcgtt ttgagctgca ttgctgcgtg cttgatgctt

181 gtcccttttg atcgtggtga tttagagggt gaactcactg gaatggggat gcttgcatgt

241 gtaatcttac taagagctaa tagaaaggct aggaccaaac cagaaacctc caattctcat

301 gtggaagccc atgccctcac cctccaacat gaaagcctct gcagcacttc tgtgtctgct

361 gctcacagca gctgctttca gcccccaggg gcttgctcag ccagttggga ttaatacttc

421 aactacctgc tgctacagat ttatcaataa gaaaatccct aagcagaggc tggagagcta

481 cagaaggacc accagtagcc actgtccccg ggaagctgta atcttcaaga ccaaactgga

541 caaggagatc tgtgctgacc ccacacagaa gtgggtccag gactttatga agcacctgga

601 caagaaaacc caaactccaa agctttgaac attcatgact gaactgaaaa caagccatga

661 cttgagaaac aaataatttg tataccctgt cctttctcag agtggttctg agattatttt

721 aatctaattc taaggaatat gagctttatg taataatgtg aatcatggtt tttcttagta

781 gattttaaaa gttattaata ttttaattta atcttccatg gattttggtg ggttttgaac

841 ataaagcctt ggatgtatat gtcatctcag tgctgtaaaa actgtgggat gctcctccct

901 tctctacctc atgggggtat tgtataagtc cttgcaagaa tcagtgcaaa gatttgcttt EPI-109 761

961 aattgttaag atatgatgtc cctatggaag catattgtta ttatataatt acatatttgc 1021 atatgtatga ctcccaaatt ttcacataaa atagattttt gtataacaaa aaaaaaaaaa 1081 aaaaa

1 ggatccttaa gccatcatgc aaaatatcta gccatgtgga gggaccactg gaaagatcac

61 acacacacac acacacacac acacacacac atacagagag agagagagac acctgagaaa

121 ttccatctgg tccaactgct ggctgttgaa gtcctcccag cccagacccc agacactgaa

181 tgaaggcctt gtgatatagt caagagcaaa aaaacccaga agattgttat tgttttaagt

241 cactgttttc agatagattg ctatgcagca atagattatt gaaatagaca ctacaatttt

301 aggtactatt attctaagaa tattgaattt tatttttctg ctaatgttct attattttac

361 ttttctctgg gttttagaaa gccaccagga tttaagacag tgaagaatct ttgagtcctt

421 tgtagagttg aaccaaagtt tgaatgtctc tttgtggact cgtgtcctag ggataccact

481 ccaaagggaa aaggggaata tcccttacat atctttgact ttggtatccc tgattccttc

541 ctttttctat agaatgtgtc tcatttcaga gaaactggtc tcttgataat agccatagat

601 tacatactgt ggtcttcctc tacatagacc ctacctcacc taccactcct ggtcttagct

661 gaaaaacagg ctagcctcga ctcatactgt catttcctat cctcccactg aagtgcactg

721 gctcagcaga tttattactc catagattta ttactccatt ctatgattca tcctctctgc

781 ttcctataaa aggcagagac agagcttcca gaggagcaga ggggctgaga ccaaaccaga

841 aacctccaat tctcatgtgg aagcccatgc cctcaccctc caacatgaaa gcctctgcag

901 cacttctgtg tctgctgctc acagcagctg ctttcagccc ccaggggctt gctcagccag

961 gtaaggtccc tctctccttc tccttgaagc acattgcccc ctctctgggt tatcctggac

1021 caatcaagaa gacctgatac ccacagtctc actttaacag ctacttttcc aagataaggt

1081 aacttagaaa aaggataagg ggtgagccca accacacagc tgctgttggg tagagcctga

1141 actagaattc cagctgtgaa ccccaaatcc agctccttct aggattccag ctctgggaac

1201 accctcagtg cagttaccac tccagctgct tccagcagaa tttgggatca gggtgatcaa

1261 agacaggagg cttctgggga tgggtgtgcg ggctgtttcc agataccggg agacccagaa

1321 tctggtctgt ggaagcccag cttccagaaa cagcagctct gcagaggtgg tacgtatcag

1381 ggaaactcat gaccaagcat tgaatgctca gagcctaaaa ggggatccat agttggggta

1441 cccttgctct aaggaattgg attattatat tagcccctcc tagcaatgcc cagagtagcc

1501 atcaattcct cttccgtctt tcaactggtg atggtgcatc cctatttcac agtccataaa

1561 agtgaaaggg agtttatgaa atgcctcaaa gggcagagac attgggtttg ggatgggcag

1621 cttttccctc cacctcttcc tttctttctg attccttctt cttaccattc cctgttttac

1681 aaacagaaag acccaggaca caccctcaat ggacttttct tcttgttgtt tcattgcagt

1741 tgggattaat acttcaacta cctgctgcta cagatttatc aataagaaaa tccctaagca

1801 gaggctggag agctacagaa ggaccaccag tagccactgt ccccgggaag ctgtaatgta

1861 tgtggacgat gaccacccac ccctcacacc tcagtcctag gttcttccct gggcagggaa

1921 taggactagt atcagaatga gttggagtca aatactgtga tgcatacagc atctctaacc

1981 ttatcccaga catttgccag tgagaaacaa tacaagtaaa gaaagtggct tctcactctc

2041 agctcccttt ccagctatca ttttacatct cagttcgttc cttcatcctg gaaccaagag

2101 agattcactt gggctaccaa aaagagctgc ttctctgagt ccccttcctt tgttttatct

2161 tcttccttca tccctgaggc atccccatca gctaggctga tgggctagac agatttccca

2221 tagacttggt cacactccca ggctgaaccc tcaaggtgtt ccatctgact gtctcctttc

2281 tgctccacag cttcaagacc aaactggaca aggagatctg tgctgacccc acacagaagt

2341 gggtccagga ctttatgaag cacctggaca agaaaaccca aactccaaag ctttgaacat

2401 tcatgactga actgaaaaca agccatgact tgagaaacaa ataatttgta taccctgtcc

2461 tttctcagag tggttctgag attattttaa tctaattcta aggaatatga gctttatgta

2521 ataatgtgaa tcatggtttt tcttagtaga ttttaaaagt tattaatatt ttaatttaat

2581 cttccatgga ttttggtggg ttttgaacat aaagccttgg atgtatatgt catctcagtg

2641 ctgtaaaaac tgtgggatgc tcctcccttc tctacctcat gggggtattg tataagtcct

2701 tgcaagaatc agtgcaaaga tttgctttaa ttgttaagat atgatgtccc tatggaagca

2761 tattgttatt atataattac atatttgcat atgtatgact cccaaatttt cacataaaat

2821 agatttttgt ataacagctg ccattcatgg ttttttaaag gataagtaat aaagctggtg

2881 gggta

(2) INFORMATION FOR SEQ ID NO:2588: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 721 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2588

1 aaccgagagg ctgagactaa cccagaaaga tccaattctc aaactgaagc tcgcactctc

61 gcctccagca tgaaagtctc tgccgccctt ctgtgcctgc tgctcatagc agccaccttc

121 attccccaag ggctcgctca gccagatgca atcaatgccc cagtcacctg ctgttataac

181 ttcaccaata ggaagatctc agtgcagagg ctcgcgagct atagaagaat caccagcagc

241 aagtgtccca aagaagctgt gatcttcaag accattgtgg ccaaggagat ctgtgctgac

301 cccaagcaga agtgggttca ggattccatg gaccacctgg acaagcaaac ccaaactccg

361 aagacttgaa cactcactcc acaacccaag aatctgcagc taacttattt tcccctagct

421 ttccccagac accctgtttt attttattat aatgaatttt gtttgttgat gtgaaacatt

481 atgccttaag taatgttaat tcttatttaa gttattgatg ttttaagttt atctttcatg EPI-109 762

541 gtactagtgt tttttagata cagagacttg gggaaattgc ttttcctctt gaaccacagt

601 tctacccctg ggatgttttg agggtctttg caagaatcat taatacaaag aatttttttt

661 aacattccaa tgcattgcta aaatattatt gtggaaatga atattttgta actattacac

721 caaataaata tatttttgta c

(2) INFORMATION FOR SEQ ID NO: 2589: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1501 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2589

1 agcccatgtc ctctcttttc aggtgatgac tttcccctga ggaagccctg tagcgtgcct

61 ggaggaaggg gctctccaac cccagcccca cctagccacc atgaacactt cagccccacc

121 tgctgtcagc cccaacatca ccgtcctggc accaggaaag ggtccctggc aagtggcctt

181 cattgggatc accacgggcc tcctgtcgct agccacagtg acaggcaacc tgctggtact

241 catctctttc aaggtcaaca cggagctcaa gacagtcaat aactacttcc tgctgagcct

301 ggcctgtgct gacctcatca tcggtacctt ctccatgaac ctctatacca cgtacctgct

361 catgggccac tgggctctgg gcacgctggc ttgtgacctc tggctggccc tggactatgt

421 ggccagcaat gcctccgtca tgaatctgct gctcatcagc tttgaccgct acttctccgt

481 gactcggccc ctgagctacc gtgccaagcg cacaccccgc cgggcagctc tgatgatcgg

541 cctggcctgg ctggtttcct ttgtgctctg ggccccagcc atcctcttct ggcagtacct

601 ggtaggggag cggacgatgc tagctgggca gtgctacatc cagttcctct cccagcccat

661 catcaccttt ggcacagcca tggctgcctt ctacctccct gtcacagtca tgtgcacgct

721 ctactggcgc atctaccggg agacagagaa ccgagcacgg gagctggcag cccttcaggg

781 ctccgagacg ccaggcaaag ggggtggcag cagcagcagc tcagagaggt ctcagccagg

841 ggctgagggc tcaccagaga ctcctccagg ccgctgctgt cgctgctgcc gggcccccag

901 gctgctgcag gcctacagct ggaaggaaga agaggaagag gacgaaggct ccatggagtc

961 cctcacatcc tcagagggag aggagcctgg ctccgaagtg gtgatcaaga tgccaatggt

1021 ggaccccgag gcacaggccc ccaccaagca gcccccacgg agctccccaa atacagtcaa

1081 gaggccgact aagaaagggc gtgatcgagc tggcaagggc cagaagcccc gtggaaagga

1141 gcagctggcc aagcggaaga ccttctcgct ggtcaaggag aagaaggcgg ctcggaccct

1201 gagtgccatc ctcctggcct tcatcctcac ctggacaccg tacaacatca tggtgctggt

1261 gtccaccttc tgcaaggact gtgttcccga gaccctgtgg gagctgggct actggctgtg

1321 ctacgtcaac agcaccatca accccatgtg ctacgcactc tgcaacaaag ccttccggga

1381 cacctttcgc ctgctgctgc tttgccgctg ggacaagaga cgctggcgca agatccccaa

1441 gcgccctggc tccgtgcacc gcactccctc ccgccaatgc tgatagtccc ctctcctgca

1501 tccctccacc ccagtccccg gg

(2) INFORMATION FOR SEQ ID NO:2590: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1561 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2590

1 attttaaacc aatgtttata ttatgtttgt taattttatt ctatttcctt gcaggtttaa

61 atgtttattt gctacttggc tactgattag agaacgcaaa atgaataact caacaaactc

121 ctctaacaat agcctggctc ttacaagtcc ttataagaca tttgaagtgg tgtttattgt

181 cctggtggct ggatccctca gtttggtgac cattatcggg aacatcctag tcatggtttc

241 cattaaagtc aaccgccacc tccagaccgt caacaattac tttttattca gcttggcctg

301 tgctgacctt atcataggtg ttttctccat gaacttgtac accctctaca ctgtgattgg

361 ttactggcct ttgggacctg tggtgtgtga cctttggcta gccctggact atgtggtcag

421 caatgcctca gttatgaatc tgctcatcat cagctttgac aggtacttct gtgtcacaaa

481 acctctgacc tacccagtca agcggaccac aaaaatggca ggtatgatga ttgcagctgc

541 ctgggtcctc tctttcatcc tctgggctcc agccattctc ttctggcagt tcattgtagg

601 ggtgagaact gtggaggatg gggagtgcta cattcagttt ttttccaatg ctgctgtcac

661 ctttggtacg gctattgcag ccttctattt gccagtgatc atcatgactg tgctatattg

721 gcacatatcc cgagccagca agagcaggat aaagaaggac aagaaggagc ctgttgccaa

781 ccaagacccc gtttctccaa gtctggtaca aggaaggata gtgaagccaa acaataacaa

841 catgcccagc agtgacgatg gcctggagca caacaaaatc cagaatggca aagcccccag

901 ggatcctgtg actgaaaact gtgttcaggg agaggagaag gagagctcca atgactccac

961 ctcagtcagt gctgttgcct ctaatatgag agatgatgaa ataacccagg atgaaaacac

1021 agtttccact tccctgggcc attccaaaga tgagaactct aagcaaacat gcatcagaat

1081 tggcaccaag accccaaaaa gtgactcatg taccccaact aataccaccg tggaggtagt

1141 ggggtcttca ggtcagaatg gagatgaaaa gcagaatatt gtagcccgca agattgtgaa

1201 gatgactaag cagcctgcaa aaaagaagcc tcctccttcc cgggaaaaga aagtcaccag

1261 gacaatcttg gctattctgt tggctttcat catcacttgg gccccataca atgtcatggt

1321 gctcattaac accttttgtg caccttgcat ccccaacact gtgtggacaa ttggttactg EPI-109 763

1381 gctttgttac atcaacagca ctatcaaccc tgcctgctat gcactttgca atgccacctt

1441 caagaagacc tttaaacacc ttctcatgtg tcattataag aacataggcg ctacaaggta

1501 aaatatcttt gaaaaagata gaaggtgggc aaggggagct tgagaagaat aaaagggata 1561 aacgagctc

(2) INFORMATION FOR SEQ ID NO: 2591: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1681 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2591

1 tccagtgtac ctccagatga ctcccccatt ccctcctgta gttcatgctt ttctctcccc

61 ttcctcccca gacacggcct acccacccct ggcaaccaac atggccaact tcacacctgt

121 caatggcagc tcgggcaatc agtccgtgcg cctggtcacg tcatcatccc acaatcgcta

181 tgagacggtg gaaatggtct tcattgccac agtgacaggc tccctgagcc tggtgactgt

241 cgtgggcaac atcctggtga tgctgtccat caaggtcaac aggcagctgc agacagtcaa

301 caactacttc ctcttcagcc tggcgtgtgc tgatctcatc ataggcgcct tctccatgaa

361 cctctacacc gtgtacatca tcaagggcta ctggcccctg ggcgccgtgg tctgcgacct

421 gtggctggcc ctggactacg tggtgagcaa cgcctccgtc atgaaccttc tcatcatcag

481 ctttgaccgc tacttctgcg tcaccaagcc tctcacctac cctgcccggc gcaccaccaa

541 gatggcaggc ctcatgattg ctgctgcctg ggtactgtcc ttcgtgctct gggcgcctgc

601 catcttgttc tggcagtttg tggtgggtaa gcggacggtg cccgacaacc agtgcttcat

661 ccagttcctg tccaacccag cagtgacctt tggcacagcc attgctgcct tctacctgcc

721 tgtggtcatc atgacggtgc tgtacatcca catctccctg gccagtcgca gccgagtcca

781 caagcaccgg cccgagggcc cgaaggagaa gaaagccaag acgctggcct tcctcaagag

841 cccactaatg aagcagagcg tcaagaagcc cccgcccggg gaggccgccc gggaggagct

901 gcgcaatggc aagctggagg aggccccccc gccagcgctg ccaccgccac cgcgccccgt

961 ggctgataag gacacttcca atgagtccag ctcaggcagt gccacccaga acaccaagga

1021 acgcccagcc acagagctgt ccaccacaga ggccaccacg cccgccatgc ccgcccctcc

1081 cctgcagccg cgggccctca acccagcctc cagatggtcc aagatccaga ttgtgacgaa

1141 gcagacaggc aatgagtgtg tgacagccat tgagattgtg cctgccacgc cggctggcat

1201 gcgccctgcg gccaacgtgg cccgcaagtt cgccagcatc gctcgcaacc aggtgcgcaa

1261 gaagcggcag atggcggccc gggagcgcaa agtgacacga acgatctttg ccattctgct

1321 agccttcatc ctcacctgga cgccctacaa cgtcatggtc ctggtgaaca ccttctgcca

1381 gagctgcatc cctgacacgg tgtggtccat tggctactgg ctctgctacg tcaacagcac

1441 catcaaccct gcctgctatg ctctgtgcaa cgccaccttt aaaaagacct tccggcacct

1501 gctgctgtgc cagtatcgga acatcggcac tgccaggtag gcaggcagga gtgccctagg

1561 aggtgctggt gttgcgtgcg tgtgctgggg ggaccacacg gctcacttgc tgtggggaag

1621 agttgcaggc accattctgc gttcacgttt gctgaggagg aagttcagaa gaggctctgt

1681 ggctgcattc agagaccaga tct

(2) INFORMATION FOR SEQ ID NO:2592: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1861 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2592

1 tcttttaacg tatgtaatgc aaagaacaaa caaataaagg cagaaatttt tctaactctg

61 tctcttctct ctttccccca gactatgtca gagagtcaca atgaccttgc acaataacag

121 tacaacctcg cctttgtttc caaacatcag ctcctcctgg atacacagcc cctccgatgc

181 agggctgccc ccgggaaccg tcactcattt cggcagctac aatgtttctc gagcagctgg

241 caatttctcc tctccagacg gtaccaccga tgaccctctg ggaggtcata ccgtctggca

301 agtggtcttc atcgctttct taacgggcat cctggccttg gtgaccatca tcggcaacat

361 cctggtaatt gtgtcattta aggtcaacaa gcagctgaag acggtcaaca actacttcct

421 cttaagcctg gcctgtgccg atctgattat cggggtcatt tcaatgaatc tgtttacgac

481 ctacatcatc atgaatcgat gggccttagg gaacttggcc tgtgacctct ggcttgccat

541 tgactacgta gccagcaatg cctctgttat gaatcttctg gtcatcagct ttgacagata

601 cttttccatc acgaggccgc tcacgtaccg agccaaacga acaacaaaga gagccggtgt

661 ■ gatgatcggt ctggcttggg tcatctcctt tgtcctttgg gctcctgcca tcttgttctg

721 gcaatacttt gttggaaaga gaactgtgcc tccgggagag tgcttcattc agttcctcag

781 tgagcccacc attacttttg gcacagccat cgctgctttt tatatgcctg tcaccattat

841 gactatttta tactggagga tctataagga aactgaaaag cgtaccaaag agcttgctgg

901 cctgcaagcc tctgggacag aggcagagac agaaaacttt gtccacccca cgggcagttc

961 tcgaagctgc agcagttacg aacttcaaca gcaaagcatg aaacgctcca acaggaggaa

1021 gtatggccgc tgccacttct ggttcacaac caagagctgg aaacccagct ccgagcagat

1081 ggaccaagac cacagcagca gtgacagttg gaacaacaat gatgctgctg cctccctgga

1141 gaactccgcc tcctccgacg aggaggacat tggctccgag acgagagcca tctactccat EPI-109 764

1201 cgtgctcaag cttccgggtc acagcaccat cctcaactcc accaagttac cctcatcgga

1261 caacctgcag gtgcctgagg aggagctggg gatggtggac ttggagagga aagccgacaa

1321 gctgcaggcc cagaagagcg tggacgatgg aggcagtttt ccaaaaagct tctccaagct

1381 tcccatccag ctagagtcag ccgtggacac agctaagact tctgacgtca actcctcagt

1441 gggtaagagc acggccactc tacctctgtc cttcaaggaa gccactctgg ccaagaggtt

1501 tgctctgaag accagaagtc agatcactaa gcggaaaagg atgtccctgg tcaaggagaa

1561 gaaagcggcc cagaccctca gtgcgatctt gcttgccttc atcatcactt ggaccccata

1621 caacatcatg gttctggtga acaccttttg tgacagctgc atacccaaaa ccttttggaa

1681 tctgggctac tggctgtgct acatcaacag caccgtgaac cccgtgtgct atgctctgtg

1741 caacaaaaca ttcagaacca ctttcaagat gctgctgctg tgccagtgtg acaaaaaaaa 1801 gaggcgcaag cagcagtacc agcagagaca gtcggtcatt tttcacaagc gcgcacccga

1861 gcaggccttg tagaatgagg ttgtatcaat agcagtgaca aaacgacaca tea

(2) INFORMATION FOR SEQ ID NO:2593: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 6604 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2593

1 agcccatgtc ctctcttttc aggtgatgac tttcccctga ggaagccctg tagcgtgcct

61 ggaggaaggg gctctccaac cccagcccca cctagccacc atgaacactt cagccccacc

121 tgctgtcagc cccaacatca ccgtcctggc accaggaaag ggtccctggc aagtggcctt

181 cattgggatc accacgggcc tcctgtcgct agccacagtg acaggcaacc tgctggtact

241 catctctttc aaggtcaaca cggagctcaa gacagtcaat aactacttcc tgctgagcct

301 ggcctgtgct gacctcatca tcggtacctt ctccatgaac ctctatacca cgtacctgct

361 catgggccac tgggctctgg gcacgctggc ttgtgacctc tggctggccc tggactatgt

421 ggccagcaat gcctccgtca tgaatctgct gctcatcagc tttgaccgct acttctccgt

481 gactcggccc ctgagctacc gtgccaagcg cacaccccgc cgggcagctc tgatgatcgg

541 cctggcctgg ctggtttcct ttgtgctctg ggccccagcc atcctcttct ggcagtacct

601 ggtaggggag cggacgatgc tagctgggca gtgctacatc cagttcctct cccagcccat

661 catcaccttt ggcacagcca tggctgcctt ctacctccct gtcacagtca tgtgcacgct

721 ctactggcgc atctaccggg agacagagaa ccgagcacgg gagctggcag cccttcaggg

781 ctccgagacg ccaggcaaag ggggtggcag cagcagcagc tcagagaggt ctcagccagg

841 ggctgagggc tcaccagaga ctcctccagg ccgctgctgt cgctgctgcc gggcccccag

901 gctgctgcag gcctacagct ggaaggaaga agaggaagag gacgaaggct ccatggagtc

961 cctcacatcc tcagagggag aggagcctgg ctccgaagtg gtgatcaaga tgccaatggt

1021 ggaccccgag gcacaggccc ccaccaagca gcccccacgg agctccccaa atacagtcaa

1081 gaggccgact aagaaagggc gtgatcgagc tggcaagggc cagaagcccc gtggaaagga

1141 gcagctggcc aagcggaaga ccttctcgct ggtcaaggag aagaaggcgg ctcggaccct

1201 gagtgccatc ctcctggcct tcatcctcac ctggacaccg tacaacatca tggtgctggt

1261 gtccaccttc tgcaaggact gtgttcccga gaccctgtgg gagctgggct actggctgtg

1321 ctacgtcaac agcaccatca accccatgtg ctacgcactc tgcaacaaag ccttccggga

1381 cacctttcgc ctgctgctgc tttgccgctg ggacaagaga cgctggcgca agatccccaa

1441 gcgccctggc tccgtgcacc gcactccctc ccgccaatgc tgatagtccc ctctcctgca

1501 tccctccacc ccagtccccg gg

1 attttaaacc aatgtttata ttatgtttgt taattttatt ctatttcctt gcaggtttaa

61 atgtttattt gctacttggc tactgattag agaacgcaaa atgaataact caacaaactc

121 ctctaacaat agcctggctc ttacaagtcc ttataagaca tttgaagtgg tgtttattgt

181 cctggtggct ggatccctca gtttggtgac cattatcggg aacatcctag tcatggtttc

241 cattaaagtc aaccgccacc tccagaccgt caacaattac tttttattca gcttggcctg

301 tgctgacctt atcataggtg ttttctccat gaacttgtac accctctaca ctgtgattgg

361 ttactggcct ttgggacctg tggtgtgtga cctttggcta gccctggact atgtggtcag

421 caatgcctca gttatgaatc tgctcatcat cagctttgac aggtacttct gtgtcacaaa

481 acctctgacc tacccagtca agcggaccac aaaaatggca ggtatgatga ttgcagctgc

541 ctgggtcctc tctttcatcc tctgggctcc agccattctc ttctggcagt tcattgtagg

601 ggtgagaact gtggaggatg gggagtgcta cattcagttt ttttccaatg ctgctgtcac

661 ctttggtacg gctattgcag ccttctattt gccagtgatc atcatgactg tgctatattg

721 gcacatatcc cgagccagca agagcaggat aaagaaggac aagaaggagc ctgttgccaa

781 ccaagacccc gtttctccaa gtctggtaca aggaaggata gtgaagccaa acaataacaa

841 catgcccagc agtgacgatg gcctggagca caacaaaatc cagaatggca aagcccccag

901 ggatcctgtg actgaaaact gtgttcaggg agaggagaag gagagctcca atgactccac

961 ctcagtcagt gctgttgcct ctaatatgag agatgatgaa ataacccagg atgaaaacac

1021 agtttccact tccctgggcc attccaaaga tgagaactct aagcaaacat gcatcagaat

1081 tggcaccaag accccaaaaa gtgactcatg taccccaact aataccaccg tggaggtagt

1141 ggggtcttca ggtcagaatg gagatgaaaa gcagaatatt gtagcccgca agattgtgaa

1201 gatgactaag cagcctgcaa aaaagaagcc tcctccttcc cgggaaaaga aagtcaccag

1261 gacaatcttg gctattctgt tggctttcat catcacttgg gccccataca atgtcatggt

1321 gctcattaac accttttgtg caccttgcat ccccaacact gtgtggacaa ttggttactg EPI-109 765

1381 gctttgttac atcaacagca ctatcaaccc tgcctgctat gcactttgca atgccacctt 1441 caagaagacc tttaaacacc ttctcatgtg tcattataag aacataggcg ctacaaggta 1501 aaatatcttt gaaaaagata gaaggtgggc aaggggagct tgagaagaat aaaagggata 1561 aacgagctc

1 tccagtgtac ctccagatga ctcccccatt ccctcctgta gttcatgctt ttctctcccc

61 ttcctcccca gacacggcct acccacccct ggcaaccaac atggccaact tcacacctgt

121 caatggcagc tcgggcaatc agtccgtgcg cctggtcacg tcatcatccc acaatcgcta

181 tgagacggtg gaaatggtct tcattgccac agtgacaggc tccctgagcc tggtgactgt

241 cgtgggcaac atcctggtga tgctgtccat caaggtcaac aggcagctgc agacagtcaa

301 caactacttc ctcttcagcc tggcgtgtgc tgatctcatc ataggcgcct tctccatgaa

361 cctctacacc gtgtacatca tcaagggcta ctggcccctg ggcgccgtgg tctgcgacct

421 gtggctggcc ctggactacg tggtgagcaa cgcctccgtc atgaaccttc tcatcatcag

481 ctttgaccgc tacttctgcg tcaccaagcc tctcacctac cctgcccggc gcaccaccaa

541 gatggcaggc ctcatgattg ctgctgcctg ggtactgtcc ttcgtgctct gggcgcctgc

601 catcttgttc tggcagtttg tggtgggtaa gcggacggtg cccgacaacc agtgcttcat

661 ccagttcctg tccaacccag cagtgacctt tggcacagcc attgctgcct tctacctgcc

721 tgtggtcatc atgacggtgc tgtacatcca catctccctg gccagtcgca gccgagtcca

781 caagcaccgg cccgagggcc cgaaggagaa gaaagccaag acgctggcct tcctcaagag

841 cccactaatg aagcagagcg tcaagaagcc cccgcccggg gaggccgccc gggaggagct

901 gcgcaatggc aagctggagg aggccccccc gccagcgctg ccaccgccac cgcgccccgt

961 ggctgataag gacacttcca atgagtccag ctcaggcagt gccacccaga acaccaagga

1021 acgcccagcc acagagctgt ccaccacaga ggccaccacg cccgccatgc ccgcccctcc

1081 cctgcagccg cgggccctca acccagcctc cagatggtcc aagatccaga ttgtgacgaa

1141 gcagacaggc aatgagtgtg tgacagccat tgagattgtg cctgccacgc cggctggcat

1201 gcgccctgcg gccaacgtgg cccgcaagtt cgccagcatc gctcgcaacc aggtgcgcaa

1261 gaagcggcag atggcggccc gggagcgcaa agtgacacga acgatctttg ccattctgct

1321 agccttcatc ctcacctgga cgccctacaa cgtcatggtc ctggtgaaca ccttctgcca

1381 gagctgcatc cctgacacgg tgtggtccat tggctactgg ctctgctacg tcaacagcac

1441 catcaaccct gcctgctatg ctctgtgcaa cgccaccttt aaaaagacct tccggcacct

1501 gctgctgtgc cagtatcgga acatcggcac tgccaggtag gcaggcagga gtgccctagg

1561 aggtgctggt gttgcgtgcg tgtgctgggg ggaccacacg gctcacttgc tgtggggaag

1621 agttgcaggc accattctgc gttcacgttt gctgaggagg aagttcagaa gaggctctgt

1681 ggctgcattc agagaccaga tct

1 tcttttaacg tatgtaatgc aaagaacaaa caaataaagg cagaaatttt tctaactctg

61 tctcttctct ctttccccca gactatgtca gagagtcaca atgaccttgc acaataacag

121 tacaacctcg cctttgtttc caaacatcag ctcctcctgg atacacagcc cctccgatgc

181 agggctgccc ccgggaaccg tcactcattt cggcagctac aatgtttctc gagcagctgg

241 caatttctcc tctccagacg gtaccaccga tgaccctctg ggaggtcata ccgtctggca

301 agtggtcttc atcgctttct taacgggcat cctggccttg gtgaccatca tcggcaacat

361 cctggtaatt gtgtcattta aggtcaacaa gcagctgaag acggtcaaca actacttcct

421 cttaagcctg gcctgtgccg atctgattat cggggtcatt tcaatgaatc tgtttacgac

481 ctacatcatc atgaatcgat gggccttagg gaacttggcc tgtgacctct ggcttgccat

541 tgactacgta gccagcaatg cctctgttat gaatcttctg gtcatcagct ttgacagata

601 cttttccatc acgaggccgc tcacgtaccg agccaaacga acaacaaaga gagccggtgt

661 gatgatcggt ctggcttggg tcatctcctt tgtcctttgg gctcctgcca tcttgttctg

721 gcaatacttt gttggaaaga gaactgtgcc tccgggagag tgcttcattc agttcctcag

781 tgagcccacc attacttttg gcacagccat cgctgctttt tatatgcctg tcaccattat

841 gactatttta tactggagga tctataagga aactgaaaag cgtaccaaag agcttgctgg

901 cctgcaagcc tctgggacag aggcagagac agaaaacttt gtccacccca cgggcagttc

961 tcgaagctgc agcagttacg aacttcaaca gcaaagcatg aaacgctcca acaggaggaa

1021 gtatggccgc tgccacttct ggttcacaac caagagctgg aaacccagct ccgagcagat

1081 ggaccaagac cacagcagca gtgacagttg gaacaacaat gatgctgctg cctccctgga

1141 gaactccgcc tcctccgacg aggaggacat tggctccgag acgagagcca tctactccat

1201 cgtgctcaag cttccgggtc acagcaccat cctcaactcc accaagttac cctcatcgga

1261 caacctgcag gtgcctgagg aggagctggg gatggtggac ttggagagga aagccgacaa

1321 gctgcaggcc cagaagagcg tggacgatgg aggcagtttt ccaaaaagct tctccaagct

1381 tcccatccag ctagagtcag ccgtggacac agctaagact tctgacgtca actcctcagt

1441 gggtaagagc acggccactc tacctctgtc cttcaaggaa gccactctgg ccaagaggtt

1501 tgctctgaag accagaagtc agatcactaa gcggaaaagg atgtccctgg tcaaggagaa

1561 gaaagcggcc cagaccctca gtgcgatctt gcttgccttc atcatcactt ggaccccata

1621 caacatcatg gttctggtga acaccttttg tgacagctgc atacccaaaa ccttttggaa

1681 tctgggctac tggctgtgct acatcaacag caccgtgaac cccgtgtgct atgctctgtg

1741 caacaaaaca ttcagaacca ctttcaagat gctgctgctg tgccagtgtg acaaaaaaaa

1801 gaggcgcaag cagcagtacc agcagagaca gtcggtcatt tttcacaagc gcgcacccga

1861 gcaggccttg tagaatgagg ttgtatcaat agcagtgaca aaacgacaca tea

(2) INFORMATION FOR SEQ ID NO: 2594: EPI-109 766

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1201 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2594

1 atggataacg tcctcccggt ggactcagac ctctccccaa acatctccac taacacctcg

61 gaacccaatc agttcgtgca accagcctgg caaattgtcc tttgggcagc tgcttacacg

121 gtcattgtgg tgacctctgt ggtgggcaac gtggtagtga tgtggatcat cttagcccac

181 aaaagaatga ggacagtgac gaactatttt ctggtgaacc tggccttcgc ggaggcctcc

241 atggctgcat tcaatacagt ggtgaacttc acctatgctg tccacaacga atggtactac

301 ggcctgttct actgcaagtt ccacaacttc ttccccatcg ccgcttgctt cgccagtatc

361 tactccatga cggctgtggc ctttgatagg tacatggcca tcatacatcc cctccagccc

421 cggctgtcag ccacagccac caaagtggtc atctgtgtca tctgggtcct ggctctcctg

481 ctggccttcc cccagggcta ctactcaacc acagagacca tgcccagcag agtcgtgtgc

541 atgatcgaat ggccagagca tccgaacaag atttatgaga aagtgtacca catctgtgtg

601 actgtgctga tctacttcct ccccctgctg gtgattggct atgcatacac catagtggga

661 atcacactat gggccagtga gatccccggg gactcctctg accgctacca cgagcaagtc

721 tctgccaagc gcaaggtggt caaaatgatg attgtcgtgg tgtgcacctt cgccatctgc

781 tggctgccct tccacatct.t cttcctcctg ccctacatca acccagatct ctacctgaag

841 aagtttatcc agcaggtcta cctggccatc atgtggctgg ccatgagctc caccatgtac

901 aaccccatca tctactgctg cctcaatgac aggttccgtc tgggcttcaa gcatgccttc

961 cggtgctgcc ccttcatcag cgccggcgac tatgaggggc tggaaatgaa atccacccgg

1021 tatctccaga cccagggcag tgtgtacaaa gteagccgcc tggagaccae catctccaca

1081 gtggtggggg cccacgagga ggagccagag gacggcccca aggccacace ctcgtccctg

1141 gacctgacet ccaactgctc ttcacgaagt gactccaaga ccatgacaga gagettcagc

1201 ttctcctcca atgtgctctc ctagggatcc

(2) INFORMATION FOR SEQ ID NO:2595: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1741 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2595 1 ctattgcagt atctttcagc ttccagtctt atctgaagac cccggcacca aagtgaccag

61 gaggcagaga agaacttcag aggagtctcg tcttgggctg cccgtgggtg agtgggaggg

121 tccgggactg cagaccggtg gcgatggcca ctctcccagc agcagaaacc tggatagacg

181 ggggtggagg cgtgggtgca gacgccgtga acctgaccgc ctcgctagct gccggggcgg

241 ccacgggggc agttgagact gggtggctgc aactgctgga ccaagctggc aacctctcct

301 cctccccttc cgcgctggga ctgcctgtgg cttcccccgc gccctcccag ccctgggcca

361 acctcaccaa ccagttcgtg cagccgtcct ggcgcatcgc gctctggtcc ctggcgtatg

421 gtgtggtggt ggcagtggca gttttgggaa atctcatcgt catctggatc atcctggccc

481 acaagcgcat gaggactgtc accaactact tccttgtgaa cctggctttc tccgacgcct

541 ccatggccgc cttcaacacg ttggtcaatt tcatctacgc gcttcatagc gagtggtact

601 ttggcgccaa ctactgccgc ttccagaact tctttcctat cacagctgtg ttcgccagca

661 tctactccat gacggccatt gcggtggaca ggtatatggc tattattgat cccttgaaac

721 ccagactgtc tgctacagca accaagattg tcattggaag tatttggatt ctagcatttc

781 tacttgcctt ccctcagtgt ctttattcca aaaccaaagt catgccaggc cgtactctct

841 gctttgtgca atggccagaa ggtcccaaac aacatttcac ttaccatatt atcgtcatta

901 tactggtgta ctgtttccca ttgctcatca tgggtattac atacaccatt gttggaatta

961 ctctctgggg aggagaaatc ccaggagata cctgtgacaa gtatcatgag cagctaaagg

1021 ccaaaagaaa ggttgtcaaa atgatgatta ttgttgtcat gacatttgct atctgctggc

1081 tgccctatca tatttacttc attctcactg caatctatca acaactaaat agatggaaat

1141 acatccagca ggtctacctg gctagctttt ggctggcaat gagctcaacc atgtacaatc

1201 ccatcatcta ctgctgtctg aataaaagat ttcgagctgg cttcaagaga gcatttcgct

1261 ggtgtccttt catcaaagtt tccagctatg atgagctaga gctcaagacc accaggtttc

1321 atccaaaccg gcaaagcagt atgtacaccg tgaccagaat ggagtccatg acagtcgtgt

1381 ttgaccccaa cgatgcagac accaccaggt ccagtcggaa gaaaagagca acgccaagag

1441 acccaagttt caatggctgc tctcgcagga attccaaatc tgcctccgcc acttcaagtt

1501 tcataagctc accctatacc tctgtggatg aatattctta attccatttc ctgaggtaaa

1561 agattagtgt gagaccatca tggtgccagt ctaggacccc attctcctat ttatcagtcc

1621 tgtcctatat accctctaga aacagaaagc aatttttagg cagctatggt caaattgaga

1681 aaggtagtgt ataaatgtga caaagacact aataacatgt tagcctccac ccaaaataaa

1741 atgggcttta aattt

(2) INFORMATION FOR SEQ ID NO: 2596: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1141 base pairs

(B) TYPE: nucleic acid EPI-109 767

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2596

1 atggggacct gtgacattgt gactgaagcc aatatctcat ctggccctga gagcaacacc

61 acgggcatca cagccttctc catgcccagc tggcagctgg cactgtgggc accagcctac

121 ctggccctgg tgctggtggc cgtgacgggt aatgccatcg tcatctggat catcctggcc

181 catcggagga tgcgcacagt caccaactac ttcatcgtca atctggcgct ggctgacctc

241 tgcatggctg ccttcaatgc cgccttcaac tttgtctatg ccagccacaa catctggtac

301 tttggccgtg ccttctgcta cttccagaac ctcttcccca tcacagccat gtttgtcagc

361 atctactcca tgaccgccat tgctgccgac aggtacatgg ccatcgtcca ccccttccag

421 cctcggcttt cagctcccag caccaaggcg gttattgctg gcatctggct ggtggctctc

481 gccctggcct cccctcagtg cttctactcc accgtcacca tggaccaggg tgccaccaag

541 tgcgtggtgg cctggcccga agacagcggg ggcaagacgc tcctcctgta ccacctcgtg

601 gtgatcgccc tcatctactt cctgccgctc gcggtgatgt ttgtagccta cagcgtcatc

661 ggcctcacgc tctggaggcg cgcagtgccc ggacatcagg cgcacggtgc caacctccgc

721 catctgcagg ccaagaagaa gtttgtgaag accatggtgc tggtggtgct gacgtttgcc

781 atctgctggc tgccctacca cctctacttc atcctgggca gcttccagga ggacatctac

841 tgccacaagt tcatccagca agtctacctg gcactcttct ggttggccat gagctctacc

901 atgtacaatc ccatcatcta ctgctgtctc aaccacaggt ttcgctctgg gttccggctt

961 gccttccgct gctgcccatg ggtcacaccc accaaggaag ataagctcga gctgactccc

1021 acgacctccc tctccacgag agtcaacagg tgtcacacta aggagacttt gttcatggct

1081 ggggacaeag ccccctccga ggctaceagt ggggaggcgg ggcgtcccca ggatggatca

1141 gggctatggt ttgggtatgg tttgcttgcc cccaccaaaa ctcatgttga aatttga

(2) INFORMATION FOR SEQ ID NO:2597: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4083 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2597

1 atggataacg tcctcccggt ggactcagac ctctccccaa acatctccac taacacctcg

61 gaacccaatc agttcgtgca accagcctgg caaattgtcc tttgggcagc tgcttacacg

121 gtcattgtgg tgacctctgt ggtgggcaac gtggtagtga tgtggatcat cttagcccac

181 aaaagaatga ggacagtgac gaactatttt ctggtgaacc tggccttcgc ggaggcctcc

241 atggctgcat tcaatacagt ggtgaacttc acctatgctg tccacaacga atggtactac

301 ggcctgttct actgcaagtt ccacaacttc ttccccatcg ccgcttgctt cgccagtatc

361 tactccatga cggctgtggc ctttgatagg tacatggcca tcatacatcc cctccagccc

421 cggctgtcag ccacagccac caaagtggtc atctgtgtca tctgggtcct ggctctcctg

481 ctggccttcc cccagggcta ctactcaacc acagagacca tgcccagcag agtcgtgtgc

541 atgatcgaat ggccagagca tccgaacaag atttatgaga aagtgtacca catctgtgtg

601 actgtgctga tctacttcct ccccctgctg gtgattggct atgcatacac catagtggga

661 atcacactat gggccagtga gatccccggg gactcctctg accgctacca cgagcaagtc

721 tctgccaagc gcaaggtggt caaaatgatg attgtcgtgg tgtgcacctt cgccatctgc

781 tggctgccct tccacatctt cttcctcctg ccctacatca acccagatct ctacctgaag

841 aagtttatcc agcaggtcta cctggccatc atgtggctgg ccatgagctc caccatgtac

901 aaccccatca tctactgctg cctcaatgac aggttccgtc tgggcttcaa gcatgccttc

961 cggtgctgcc ccttcatcag cgccggcgac tatgaggggc tggaaatgaa atccacccgg

1021 tatctccaga cccagggcag tgtgtacaaa gteagccgcc tggagaccae catctccaca

1081 gtggtggggg cccacgagga ggagccagag gacggcccca aggccacace ctcgtccctg

1141 gacctgacet ccaactgctc ttcacgaagt gactccaaga ccatgacaga gagettcagc

1201 ttctcctcca atgtgctctc ctagggatce

1 ctattgcagt atctttcagc ttccagtctt atctgaagac cccggcacca aagtgaccag

61 gaggcagaga agaacttcag aggagtctcg tcttgggctg cccgtgggtg agtgggaggg

121 tccgggactg cagaccggtg gcgatggcca ctctcccagc agcagaaacc tggatagacg

181 ggggtggagg cgtgggtgca gacgccgtga acctgaccgc ctcgctagct gccggggcgg

241 ccacgggggc agttgagact gggtggctgc aactgctgga ccaagctggc aacctctcct

301 cctccccttc cgcgctggga ctgcctgtgg cttcccccgc gccctcccag ccctgggcca

361 acctcaccaa ccagttcgtg cagccgtcct ggcgcatcgc gctctggtcc ctggcgtatg

421 gtgtggtggt ggcagtggca gttttgggaa atctcatcgt catctggatc atcctggccc

481 acaagcgcat gaggactgtc accaactact tccttgtgaa cctggctttc tccgacgcct

541 ccatggccgc cttcaacacg ttggtcaatt tcatctacgc gcttcatagc gagtggtact

601 ttggcgccaa ctactgccgc ttccagaact tctttcctat cacagctgtg ttcgccagca

661 tctactccat gacggccatt gcggtggaca ggtatatggc tattattgat cccttgaaac

721 ccagactgtc tgctacagca accaagattg tcattggaag tatttggatt ctagcatttc

781 tacttgcctt ccctcagtgt ctttattcca aaaccaaagt catgccaggc cgtactctct

841 gctttgtgca atggccagaa ggtcccaaac aacatttcac ttaccatatt atcgtcatta

901 tactggtgta ctgtttccca ttgctcatca tgggtattac atacaccatt gttggaatta

961 ctctctgggg aggagaaatc ccaggagata cctgtgacaa gtatcatgag cagctaaagg EPI-109 768

1021 ccaaaagaaa ggttgtcaaa atgatgatta ttgttgtcat gacatttgct atctgctggc 1081 tgccctatca tatttacttc attctcactg caatctatca acaactaaat agatggaaat 1141 acatccagca ggtctacctg gctagctttt ggctggcaat gagctcaacc atgtacaatc 1201 ccatcatcta ctgctgtctg aataaaagat ttcgagctgg cttcaagaga gcatttcgct 1261 ggtgtccttt catcaaagtt tccagctatg atgagctaga gctcaagacc accaggtttc 1321 atccaaaccg gcaaagcagt atgtacaccg tgaccagaat ggagtccatg acagtcgtgt 1381 ttgaccccaa cgatgcagae accaccaggt ccagtcggaa gaaaagagea aegecaagag 1441 acccaagttt caatggctgc tctcgcagga attccaaatc tgcctccgcc acttcaagtt 1501 tcataagctc accctatacc tctgtggatg aatattctta attccatttc ctgaggtaaa 1561 agattagtgt gagaccatca tggtgccagt ctaggacccc attctcctat ttatcagtcc 1621 tgtcctatat accctctaga aacagaaagc aatttttagg cagetatggt caaattgaga 1681 aaggtagtgt ataaatgtga caaagacact aataacatgt tagcctccac ccaaaataaa 1741 atgggcttta aattt

1 atggggacct gtgacattgt gactgaagcc aatatctcat ctggccctga gagcaacacc

61 acgggcatca cagccttctc catgcccagc tggcagctgg cactgtgggc accagcctac

121 ctggccctgg tgctggtggc cgtgacgggt aatgccatcg tcatctggat catcctggcc

181 catcggagga tgcgcacagt caccaactac ttcatcgtca atctggcgct ggctgacctc

241 tgcatggctg ccttcaatgc cgccttcaac tttgtctatg ccagccacaa catctggtac

301 tttggccgtg ccttctgcta cttccagaac ctcttcccca tcacagccat gtttgtcagc

361 atctactcca tgaccgccat tgctgccgac aggtacatgg ccatcgtcca ccccttccag

421 cctcggcttt cagctcccag caccaaggcg gttattgctg gcatctggct ggtggctctc

481 gccctggcct cccctcagtg cttctactcc accgtcacca tggaccaggg tgccaccaag

541 tgcgtggtgg cctggcccga agacagcggg ggcaagacgc tcctcctgta ccacctcgtg

601 gtgatcgccc tcatctactt cctgccgctc gcggtgatgt ttgtagccta cagcgtcatc

661 ggcctcacgc tctggaggcg cgcagtgccc ggacatcagg cgcacggtgc caacctccgc

721 catctgcagg ccaagaagaa gtttgtgaag accatggtgc tggtggtgct gacgtttgcc

781 atctgctggc tgccctacca cctctacttc atcctgggca gcttccagga ggacatctac

841 tgccacaagt tcatccagca agtctacctg gcactcttct ggttggccat gagctctacc

901 atgtacaatc ccatcatcta ctgctgtctc aaccacaggt ttcgctctgg gttccggctt

961 gccttccgct gctgcccatg ggtcacaccc accaaggaag ataagctcga gctgactccc

1021 acgacctccc tctccacgag agtcaacagg tgtcacacta aggagacttt gttcatggct

1081 ggggacaeag ccccctccga ggctaceagt ggggaggcgg ggcgtcccca ggatggatca

1141 gggctatggt ttgggtatgg tttgcttgcc cccaccaaaa ctcatgttga aatttga

(2) INFORMATION FOR SEQ ID NO:2598: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1501 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2598

1 ctccataagg cacaaacttt cagagacagc agagcacaca agcttctagg acaagagcca

61 ggaagaaacc accggaagga accatctcac tgtgtgtaaa catgacttcc aagctggccg

121 tggctctctt ggcagccttc ctgatttctg cagctctgtg tgaaggtgca gttttgccaa

181 ggagtgctaa agaacttaga tgtcagtgca taaagacata ctccaaacct ttccacccca

241 aatttatcaa agaactgaga gtgattgaga gtggaccaca ctgcgccaac acagaaatta

301 ttgtaaagct ttctgatgga agagagctct gtctggaccc caaggaaaac tgggtgcaga

361 gggttgtgga gaagtttttg aagagggctg agaattcata aaaaaattca ttctctgtgg

421 tatccaagaa tcagtgaaga tgccagtgaa acttcaagca aatctacttc aacacttcat

481 gtattgtgtg ggtctgttgt agggttgcca gatgcaatac aagattcctg gttaaatttg

541 aatttcagta aacaatgaat agtttttcat tgtaccatga aatatccaga acatacttat

601 atgtaaagta ttatttattt gaatctacaa aaaacaacaa ataattttta aatataagga

661 ttttcctaga tattgcacgg gagaatatac aaatagcaaa attgggccaa gggccaagag

721 aatatccgaa ctttaatttc aggaattgaa tgggtttgct agaatgtgat atttgaagca

781 tcacataaaa atgatgggac aataaatttt gccataaagt caaatttagc tggaaatcct

841 ggattttttt ctgttaaatc tggcaaccct agtctgctag ccaggatcca caagtccttg

901 ttccactgtg ccttggtttc tcctttattt ctaagtggaa aaagtattag ccaccatctt

961 acctcacagt gatgttgtga ggacatgtgg aagcacttta agttttttca tcataacata

1021 aattattttc aagtgtaact tattaaccta tttattattt atgtatttat ttaagcatca

1081 aatatttgtg caagaatttg gaaaaataga agatgaatca ttgattgaat agttataaag

1141 atgttatagt aaatttattt tattttagat attaaatgat gttttattag ataaatttca

1201 atcagggttt ttagattaaa caaacaaaca attgggtacc cagttaaatt ttcatttcag

1261 atatacaaca aataattttt tagtataagt acattattgt ttatctgaaa ttttaattga

1321 actaacaatc ctagtttgat actcccagtc ttgtcattgc cagctgtgtt ggtagtgctg

1381 tgttgaatta cggaataatg agttagaact attaaaacag ccaaaactcc acagtcaata

1441 ttagtaattt cttgctggtt gaaacttgtt tattatgtac aaatagattc ttataatatt

1501 atttaaatga ctgcattttt aaatacaagg ctttatattt ttaactttaa aaaaaaccgg EPI-109 769

(2) INFORMATION FOR SEQ ID NO:2599: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1561 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2599

1 gaattctctc tccagcagcc ctgccagatg cccgcccagc ccctgcctca ggcggggagg

61 gcttcaggga agctcaccaa ggcagaaggg cgggagagat tgtcagagcc ccagctggtg

121 tccagggact gaccgtgagc ctgggtgaaa gtgagttccc cgttggaggc aacagacgag

181 gagaggatgg aaggcctggc ccccaagaat gagccctgag gttcagggag cggctggagt

241 gagccggccc cagatctccg tccagctgcg ggtcccagag gcctgggtta cactcgcagc

301 tcctggggga ggcccttgac gtgcctcagt tcccaaacag gaaccctggg aaggaccaga

361 gaagtgccta ttgcgcagtg agtgcccgac acagctgcat gtggccggta tcacagggcc

421 ctgggtaaac tgaggcaggc gacacagctg catgtggccg gtatcacagg gccctgggta

481 aactgaggca ggcgacacag ctgcatgtgg ccggtatcac agggccctgg gtaaactgag

541 gcaggcgaca cagctgcatg tggccgtatc acagggccct gggtaaactg aggcaggtga

601 cacagctgca tgtggccggt atcacggggc cctggataaa cagaggcagg cgacacagct

661 gcatgtggcc ggtatcacgg ggccctgggt aaactgaggc aggcgaggcc acccccatca

721 agtccctcag gtctaggttt ggcaggtttg gcaaaaacac agcaacgctc ggttaaatct

781 gaatttcggg taagtatatc ctgggcctca tttggaagag acttagatta aaaaaaaaac

841 gtcgagacca gcccggccaa cacggtgaaa ccccgtctct actaaaaata caaaaaatta

901 gccaggcgca gtggctcacg cctgtgatcc cagcactctg ggaggctgag gcaggcggat

961 cacccgaggt cagatgttca agaccagcct ggccgacagg gcgaaacact gtctctacta

1021 caaatacaaa aattagccgg gagtggtggc aggtgcctgt aatctcagct attcaggagg

1081 ctgaggcagg agaatcactt gaacctggga ggcggaggtt gccgtgagcc gggatcacgc

1141 caccgcactc cagcctgggc gatagagcaa gactctgtct ccaaaaaaat aaattaaaaa

1201 acccacattg attatctgac atttgaatgc gattgtgcat cctgaatttt gtctggaggc

1261 cccacccgag ccaatccagc gtcttgtccc ccttctcccc cttttcatca acgccctgtg

1321 ccaggggaga ggaagtggag ggcgctggcc ggccgtgggg caatgcaacg gcctcccagc

1381 acagggctat aagaggagcc gggcgggcac ggaggggcag agaccccgga gccccagccc

1441 caccatgacc ctcggccgcc gactcgcgtg tcttttcctc gcctgtgtcc tgccggcctt

1501 gctgctgggg ggtgagtttt tgagtccaac ctcccgctgc tccctctgtc ccgggttctg

1561 t

(2) INFORMATION FOR SEQ ID NO: 2600: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 5101 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2600

1 agcttcatcc tggagtcaac agattgggtt tgaatcctgg ctctgtccct ttctagctgt

61 gtgtttggtt gttactccac ctctctgagc cttaatttct tcatcagtaa aagtaatatt

121 cacctcctag ggttgttgg^'g agggagaata agaacttcta aagtacccga acctagcaac

181 taggacacta tatttgcagg caagatgaag aggggtgggg aagtaatagg aaacagccca

241 aatcgagagc cataatagtc tctctttact tagtgccagt gcaggcctgt gattctgttc

301 ttaaaaacgt ctggggcaag ctgcaggaaa gacccgagat agcttatgtt ctaccataag

361 ccttaaggga ggaggactcc aggcagggag acttaccatg gcacctctaa gagaaagcct

421 actgaccaga gagaggtcag tcatgtactc ccgtagcttc ttagaatttc tgatctgact

481 cgctgcctct agagttgttc aggtggaaat tggaaggcta tagaggaatt cggcagcata

541 cagtggctca cgtctgtaat ccaaaatcca agcattttgg aaggccaaag taggaggatc

601 acttaagccc aggagtttaa gaccagccta ggcaaccgag tgagatccat ctccactaaa

661 aaattttaaa atttgccagg tatggtggtg tgcacctgta gccccagcta ctcaggagag

721 tcagagaatc ggcgcacccc ggagttcgag gttgcagtga gccatgatca cgccactgta

781 ctccagcctg ggtgacagag aagaccacct gtctcaaaaa acataaataa ataaataaat

841 aaataggccg tgcgcagcgg ctcacgactg taattccaac attttagaag gcggaggcag

901 cggatcacct gaggtcagga gttcgggacc agcctgacca acgtggtgaa accccaactc

961 tactaaaaat acataaatta ggcggggcgt ggtggtggcc gcctgtaatc ccagctactc

1021 ggtaggctgc agcaggagaa tggtttgaac ccgggaggca gaggttgcag tgagccaaaa

1081 tcccctcact gcattccagc ctgagactaa aaaaaagagg cgatttccca catcggtgga

1141 aatttgagct gtttaaactc tggatgcctt tttcagttct aatattccag atctccttgg

1201 tggataaaca cttcatttcc cttctcctga gcagagctcc tgagccctgg cccgctggaa

1261 cctgtcactt ctaaaaaagt tcgaggtccg gactgtctct cccggagcct tgaggctgat

1321 gagacggagc gagagagggg ccgggggcaa tggagtctac tcgcgggccc agggaggcgc

1381 cagagggccc cgggaccgac cgcaagaata acttccttcc tcttccgcta acttcccggc

1441 agggctacgc tcagggtggg ggccccgagg gctggggcgt cggcttcccc ctggggatcc

1501 cccgcttcag agaagccaag cgttagcgca gccaaagccg gaggcagcga agctccggcc

1561 cggggtggcg ctgggtcagg gtaccttctc ggcggtcccc tggccggccg aactcgcgcc EPI-109 770

1621 tggtgtcctg tcaccccgct ccccgccctg agtgagcctg tcccctctca ggggcgcgcc 1681 cgagtcgctc cgggttggct gccaggtcca gagttaaact ttcagccaat gaaaaagggc 1741 gcgagggctg acgcacggaa acgtcatggg aattcccccc tccggggggc cgagaagggg 1801 ctttcccggc cctgagccct gctggcaggc gaggtgtcgc gaccggtccc aggtgggtcg 1861 ggcgcggaga gaagccgcaa ccagagccgc cgccacggtg agtggctgga ttcagacccc 1921 tgggtggccg ggacaagaga aaagagggag gagggccttt agcggacagc gcctggggct 1981 ggagagcagc agctgcacac agccggaaag ggcgcgcagg cgacgacact cggatccacg 2041 tcgacaccgt tgtacaaaga tacgcggacc cgtacgtaca cctgtacctg tgctggcgca 2101 cacacggcag cgtccgtgca gtcgcactcg cacacacatg cacacggaga cgtgcccacc 2161 ggtgcactgg tgcctgcacc cacacccttc acgcacaaac tcaagatacg ctcacccgtg 2221 tctgtacatc aagacaggcg ctgacacaca cccacactga gaagctcggg attcacctat 2281 ctacacacat gctcgcttgc acactcatgt tgacgccatg gacacacaac atgcaaccaa 2341 gcactacagc cgaaacacac ttgtggagct gtgatggaga cacactcttg tattaggtgg 2401 gggggggggg ggagcgtgca gagatctccc tgtcgcctgc gcgcccagaa ccggtgcggt 2461 gtgggaccag ctgctgttgt gaggtttggg agagagagaa aaagagccca ctccgaggag 2521 gagacacttt tcccgcagcc ccagaatcgc gttctcgggg cagaaccccg gggcctccca 2581 caggaaagag ccccgcctac aggctgttcg aaggggaggc cgtccgacag caggaatgtc 2641 cccccaaaag cccccggggt ttatcagccg tggcctccct cctggcagaa aatcccaagg 2701 ttgctccaga ccgggggagg ggagcgggag gcggacttgg ccccagactg ccagcctcct 2761 cccggccgtg aaagaccctc ctgttccctg ccctggaggg aggagggggc ttaacccacc 2821 ggggcttccc ggattctcct agacctctgc ccgctgaaaa gcagcgggac gccgtagact 2881 gtcgagggcc atcccgcccc tcccgtcgcg agggcggggc cagtggcgtc atttccaggc 2941 ccgccccctc cggccccgcc tccccttggt attttcggga ctttcctaag ctgctctaac 3001 tttcctgccc cttccccgcc aagcccaact ccggatctcg ctctccaccg gatctcaccc 3061 gccacacccg gacaggcggc tggaggaggt cggaccctcc cccaaatctg ggcccccatt 3121 ctcccgccca cccccattta gatctgaccc cctcccccac gccactcctc ccaactttag 3181 gcgggcgtct aaaattctgg gaagcagaac ctggccggag ccactagaca gagccgggcc 3241 tagcccagag acatggagag ttgctacaac ccagtgagtc atgccgcctg cccctgaccc 3301 ggccggctag cccctcgtgt ctgtccacct gtctgcccga gccccctact gctgccttac 3361 acctgtatgc ctcgcagatg ctctcagcct gccagtctgt ccatctgtct gcaactctgc 3421 ctccaaaagg agctttctct tgggtctgag gaggaggggg gagtgaccac tgaagacttg 3481 gaagatggga ggtggggcta gtgtgggggg tgctgagagt cggatgccac ccccagtctg 3541 tctccaaacc agggtctgga tggtattatt gaatatgatg atttcaaatt gaactcctcc 3601 attgtggaac ccaaggagcc agccccagaa acaggtcagc aagttcacta acctccccta 3661 gtctaaagcg ggggagggag agcatgtgcc ctctctctgg gggaggggtc tgggagatcg 3721 tgtgctcagc aaggtctctc tgtccccagc tgatggcccc tacctggtga tcgtggaaca 3781 gcctaagcag gttgagtgag caaaagggag ggatgtggaa tggcttcagc tttggggaca 3841 aatggggtag tgtagctggc tggcatggag gagcattgcc gaagaggccc acaggggatt 3901 ggatggtcac tgctgctgat cagagtgctg tagttttggt tcagggctac taccagcgac 3961 tcgggtcact gctggcctgg gtggtcttcc ctgatcacaa tgctactatg cccttgacct 4021 tcagagaggc ttccgatttc gatatggctg tgaaggcccc tcccatggag gactgcccgg 4081 tgcctccagt gagaagggcc gaaagaccta tcccactgtc aaggtga cc aggatggtgc 4141 tggmgggtgg gctaagtgga cagcatgccc aaggccctga cgtgacagtc ccttgcctct 4201 cctagatctg taactacgag ggaccagcca agatcgaggt ggacctggta acacacagtg 4261 acccacctcg tgctcatgcc cacagtctgg tgggcaagca atgctcggag ctggggatct 4321 gcgccgtttc tgtggggccc aaggacatga ctgcccagta ggtgcccttc ttacgccttg 4381 gcccccactg gtatgccskt c tgccagtc ccaggcccca gccacctcca tatgatgtta 4441 gcatctgacc aaggggaaan gatgtaggtt ggccccaaac ccaagggcct aagtagaaac 4501 tccaatggct tccttgagga agtaaggctg agctgagcct ggcaatggga aaggtgcctg 4561 gcaatgggaa aggtgcctca ggaagaaaga actgcatggc caaaggctcc cgattctctc 4621 ttctcagatt taacaacctg ggtgtcctgc atgtgactaa gaagaacatg atggggacta 4681 tgatacaaaa acttcagagg cagcggctcc gctctaggcc ccagggcctt acgggtatgg 4741 gtgcaggggg tgggtcgggt atgggtgcag ggggtgggtg ggtcatggga ggtgctcatg 4801 gaaggagcag ggagggagaa gccaggggtc acacatgtac ctactgccca gaggccgagc 4861 agcgggagct ggagcaagag gccaaagaac tgaagaaggt gatggatctg agtatagtgc 4921 ggctgcgctt ctctgccttc cttagagcca gtgatggctc cttctccctg cccctgaagc 4981 cagtcacctc ccagcccatc catgatagca gtgagtatcc tgattgcctg gggtgccagg 5041 cctggtsgsa gaggtggcat gaggggtgac ctcaagctgt gcagtcaaac aagacccagg 5101 tttcagaacc tgcsctgcca catatgagct gagtgatcct gagcaagtca tttccccccc

(2) INFORMATION FOR SEQ ID NO:2601: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3601 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2601

1 ggccaccgga gcggcccggc gacgatcgct gacagcttcc cctgcccttc ccgtcggtcg 61 ggccgccagc cgccgcagcc ctcggcctgc acgcagccac cggccccgct cccggagccc EPI-109 771

121 agcgccgccg aggccgcagc cgcccggcca gtaaggcggc gccgcccgcg gccaccgcgg

181 gccctgccgt tccctccgcc gcgctgcgcc atggcgcggc gctgactggc ctggcccggc

241 cccgccgcgc tcccgctcgc cccgacccgc actcgggccc gcccgggctc cggcctgccg

301 ccgcctcttc cttctccagc cggcaggccc cgccgcttag gagggagagc ccacccgcgc

361 caggaggccg aacgcggact cgccacccgg cttcagaatg gcagaagatg atccatattt

421 gggaaggcct gaacaaatgt ttcatttgga tccttctttg actcatacaa tatttaatcc

481 agaagtattt caaccacaga tggcactgcc aacagatggc ccataccttc aaatattaga

541 gcaacctaaa cagagaggat ttcgtttccg ttatgtatgt gaaggcccat cccatggtgg

601 actacctggt gcctctagtg aaaagaacaa gaagtcttac cctcaggtca aaatctgcaa

661 ctatgtggga ccagcaaagg ttattgttca gttggtcaca aatggaaaaa atatccacct

721 gcatgcccac agcctggtgg gaaaacactg tgaggatggg atctgcactg taactgctgg

781 acccaaggac atggtggtcg gcttcgcaaa cctgggtata cttcatgtga caaagaaaaa

841 agtatttgaa acactggaag cacgaatgac agaggcgtgt ataaggggct ataatcctgg

901 actcttggtg caccctgacc ttgcctattt gcaagcagaa ggtggagggg accggcagct

961 gggagatcgg gaaaaagagc taatccgcca agcagctctg cagcagacca aggagatgga

1021 cctcagcgtg gtgcggctca tgtttacagc ttttcttccg gatagcactg gcagcttcac

1081 aaggcgcctg gaacccgtgg tatcagacgc catctatgac agtaaagccc ccaatgcatc

1141 caacttgaaa attgtaagaa tggacaggac agctggatgt gtgactggag gggaggaaat

1201 ttatcttctt tgtgacaaag ttcagaaaga tgacatccag attcgatttt atgaagagga

1261 agaaaatggt ggagtctggg aaggatttgg agatttttcc cccacagatg ttcatagaca

1321 atttgccatt gtcttcaaaa ctccaaagta taaagatatt aatattacaa aaccagcctc

1381 tgtgtttgtc cagcttcgga ggaaatctga cttggaaact agtgaaccaa aacctttcct

1441 ctactatcct gaaatcaaag ataaagaaga agtgcagagg aaacgtcaga agctcatgcc

1501 caatttttcg gatagtttcg gcggtggtag tggtgccgga gctggaggcg gaggcatgtt

1561 tggtagtggc ggtggaggag ggggcactgg aagtacaggt ccagggtata gcttcccaca

1621 ctatggattt cctacttatg gtgggattac tttccatcct ggaactacta aatctaatgc

1681 tgggatgaag catggaacca tggacactga atctaaaaag gaccctgaag gttgtgacaa

1741 aagtgatgac aaaaacactg taaacctctt tgggaaagtt attgaaacca cagagcaaga

1801 tcaggagccc agcgaggcca ccgttgggaa tggtgaggtc actctaacgt atgcaacagg

1861 aacaaaagaa gagagtgctg gagttcagga taacctcttt ctagagaagg ctatgcagct

1921 tgcaaagagg catgccaatg cccttttcga ctacgcggtg acaggagacg tgaagatgct

1981 gctggccgtc cagcgccatc tcactgctgt gcaggatgag aatggggaca gtgtcttaca

2041 cttagcaatc atccaccttc attctcaact tgtgagggat ctactagaag tcacatctgg

2101 tttgatttct gatgacatta tcaacatgag aaatgatctg taccagacgc ccttgcactt

2161 ggcagtgatc actaagcagg aagatgtggt ggaggatttg ctgagggctg gggccgacct

2221 gagccttctg gaccgcttgg gtaactctgt tttgcaccta gctgccaaag aaggacatga

2281 taaagttctc agtatcttac tcaagcacaa aaaggcagca ctacttcttg accaccccaa

2341 cggggacggt ctgaatgcca ttcatctagc catgatgagc aatagcctgc catgtttgct

2401 gctgctggtg gccgctgggg ctgacgtcaa tgctcaggag cagaagtccg ggcgcacagc

2461 actgcacctg gctgtggagc acgacaacat ctcattggca ggctgcctgc tcctggaggg

2521 tgatgcccat gtggacagta ctacctacga tggaaccaca cccctgcata tagcagctgg

2581 gagagggtcc accaggctgg cagctcttct caaagcagca ggagcagatc ccctggtgga

2641 gaactttgag cctctctatg acctggatga ctcttgggaa aatgcaggag aggatgaagg

2701 agttgtgcct ggaaccacgc ctctagatat ggccaccagc tggcaggtat ttgacatatt

2761 aaatgggaaa ccatatgagc cagagtttac atctgatgat ttactagcac aaggagacat

2821 gaaacagctg gctgaagatg tgaagctgca gctgtataag ttactagaaa ttcctgatcc

2881 agacaaaaac tgggctactc tggcgcagaa attaggtctg gggatactta ataatgcctt

2941 ccggctgagt cctgctcctt ccaaaacact tatggacaac tatgaggtct ctgggggtac

3001 agtcagagag ctggtggagg ccctgagaca aatgggctac accgaagcaa ttgaagtgat

3061 ccaggcagcc tccagcccag tgaagaccac ctctcaggcc cactcgctgc ctctctcgcc

3121 tgcctccaca aggcagcaaa tagacgagct ccgagacagt gacagtgtct gcgacacggg

3181 cgtggagaca tccttccgca aactcagctt taccgagtct ctgaccagtg gtgcctcact

3241 gctaactctc aacaaaatgc cccatgatta tgggcaggaa ggacctctag aaggcaaaat

3301 ttagcctgct gacaatttcc cacaccgtgt aaaccaaagc cctaaaattc cactgcgttg

3361 tccacaagac agaagctgaa gtgcatccaa aggtgctcag agagccggcc cgcctgaatc

3421 attctcgatt taactcgaga ccttttcaac ttggcttcct ttcttggttc ataaatgaat

3481 tttagtttgg ttcacttaca gatagtatct agcaatcaca acactggctg agcggatgca

3541 tctggggatg aggttgctta ctaagctttg ccagctgctg ctggatcaca gctgctttct

3601 gttgtcattg ctgttgtccc tctgc

(2) INFORMATION FOR SEQ ID NO: 2602: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1621 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2602

1 actttcctgc cccttccccg gccaagccca actccggatc tcgctctcca ccggatctca

61 cccgccacac ccggacaggc ggctggagga ggcgggcgtc taaaattctg ggaagcagaa EPI-109 772

121 cctggccgga gccactagac agagccgggc ctagcccaga gacatggaga gttgctacaa

181 cccaggtctg gatggtatta ttgaatatga tgatttcaaa ttgaactcct ccattgtgga

241 acccaaggag ccagccccag aaacagctga tggcccctac ctggtgatcg tggaacagcc

301 taagcagaga ggcttccgat ttcgatatgg ctgtgaaggc ccctcccatg gaggactgcc

361 cggtgcctcc agtgagaagg gccgaaagac ctatcccact gtcaagatct gtaactacga

421 gggaccagcc aagatcgagg tggacctggt aacacacagt gacccacctc gtgctcatgc

481 ccacagtctg gtgggcaagc aatgctcgga gctggggatc tgcgccgttt ctgtggggcc

541 caaggacatg actgcccaat ttaacaacct gggtgtcctg catgtgacta agaagaacat

601 gatggggact atgatacaaa aacttcagag gcagcggctc cgctctaggc cccagggcct

661 tacggaggcc gagcagcggg agctggagca agaggccaaa gaactgaaga aggtgatgga

721 tctgagtata gtgcggctgc gcttctctgc cttccttaga gccagtgatg gctccttctc

781 cctgcccctg aagccagtca cctcccagcc catccatgat agcaaatctc cgggggcatc

841 aaacctgaag atttctcgaa tggacaagac agcaggctct gtgcggggtg gagatgaagt

901 ttatctgctt tgtgacaagg tgcagaaaga tgacattgag gttcggttct atgaggatga

961 tgagaatgga tggcaggcct ttggggactt ctctcccaca gatgtgcata aacagtatgc

1021 cattgtgttc cggacacccc cctatcacaa gatgaagatt gagcggcctg taacagtgtt

1081 tctgcaactg aaacgcaagc gaggagggga cgtgtctgat tccaaacagt tcacctatta

1141 ccctctggtg gaagacaagg aagaggtgca gcggaagcgg aggaaggcct tgcccacctt

1201 ctcccagccc ttcgggggtg gctcccacat gggtggaggc tctgggggtg cagccggggg

1261 ctacggagga gctggaggag gtgagggggt actgatggag ggaggggtaa aggtaagaga

1321 agctgtggag gaaaaaaatc tgggggaggc cgggcgtggc ttgcacgcct gtaatccagc

1381 ctttgggagg ccaaggcagg cagttacctg agatcaggag ttcaagacca gcttggccaa

1441 cagcgtgaaa cctcgtctct actaaaaata caaacattag ctgggcatgg tggcaggcgc

1501 ctgtaatccc agctactcgg gaggctgagg caggagaatc gcttgaaccc tgggagacaa

1561 gaggttgcag taagctgaga tcacaccact gcactccagg ctgggcaata agagcgaaac

1621 tccgtctcaa aaaaaaaaaa aaaaaaaaaa

(2) INFORMATION FOR SEQ ID NO: 2603: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3061 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2603

1 cacggtgagt ggctggattc agacccctgg gtggccggga caagagaaaa gagggaggag

61 ggcctttagc ggacagcgcc tggggctgga gagcagcagc tgcacacagc cggaaagggc

121 gcgcaggcga cgacactcgg atccacgtcg acaccgttgt acaaagatac gcggacccgc

181 gggcgtctaa aattctggga agcagaacct ggccggagcc actagacaga gccgggccta

241 gcccagagac atggagagtt gctacaaccc aggtctggat ggtattattg aatatgatga

301 tttcaaattg aactcctcca ttgtggaacc caaggagcca gccccagaaa cagctgatgg

361 cccctacctg gtgatcgtgg aacagcctaa gcagagaggc ttccgatttc gatatggctg

421 tgaaggcccc tcccatggag gactgcccgg tgcctccagt gagaagggcc gaaagaccta

481 tcccactgtc aagatctgta actacgaggg accagccaag atcgaggtgg acctggtaac

541 acacagtgac ccacctcgtg ctcatgccca cagtctggtg ggcaagcaat gctcggagct

601 ggggatctgc gccgtttctg tggggcccaa ggacatgact gcccaattta acaacctggg

661 tgtcctgcat gtgactaagg agaacatgat ggggactatg atacaaaaac ttcagaggca

721 gcggctccgc tctaggcccc agggccttac ggaggccgag cagcgggagc tggagcaaga

781 ggccaaagaa ctgaagaagg tgatggatct gagtatagtg cggctgcgct tctctgcctt

841 ccttagagcc agtgatggct ccttctccct gcccctgaag ccagtcatct cccagcccat

901 ccatgacagc aaatctccgg gggcatcaaa cctgaagatt tctcgaatgg acaagacagc

961 aggctctgtg cggggtggag atgaagttta tctgctttgt gacaaggtgc agaaagatga

1021 cattgaggtt cggttctatg aggatgatga gaatggatgg caggcctttg gggacttctc

1081 tcccacagat gtgcataaac agtatgccat tgtgttccgg acacccccct atcacaagat

1141 gaagattgag cggcctgtaa cagtgtttct gcaactgaaa cgcaagcgag gaggggacgt

1201 gtctgattcc aaacagttca cctattaccc tctggtggaa gacaaggaag aggtgcagcg

1261 gaagcggagg aaggccttgc ccaccttctc ccagcccttc gggggtggct cccacatggg

1321 tggaggctct gggggtgcag ccgggggcta cggaggagct ggaggaggtg gcagcctcgg

1381 tttcttcccc tcctccctgg cctacagccc ctaccagtcc ggcgcgggcc ccatgggctg

1441 ctacccggga ggcgggggcg gggcgcagat ggccgccacg gtgcccagca gggactccgg

1501 ggaggaagcc gcggagccga gcgccccctc caggaccccc cagtgcgacg cgcaggcccc

1561 ggagatgctg cagcgagctc gagagtacaa cgcgcgcctg ttcggcctgg cgcagcgcag

1621 cgcccgagcc ctactcgact acggcgtcac cgcggaccgg cgcgcgctgc tggcgggaca

1681 gcgccacctg ctgacggcgc aggacgagaa cggagacaca ccactgcacc tagccatcat

1741 ccacgggcag accagtgtca ttgagcagat agtctatgtc atccaccacg cccaggacct

1801 cggcgttgtc aacctcacca accacctgca ccagacgccc ctgcacctgg cggtgatcac

1861 ggggcagacg agtgtggtga gctttctgct gcgggtaggt gcagacccag ctctgctgga

1921 tcggcatgga gactcagcca tgcatctggc gctgcgggca ggcgctggtg ctcctgagct

1981 gctgcgtgca ctgcttcaga gtggagctcc tgctgtgccc cagctgttgc atatgcctga

2041 ctttgaggga ctgtatccag tacacctggc ggtccgagcc cgaagccctg agtgcctgga EPI-109 773

2101 tctgctggtg gacagtgggg ctgaagtgga ggccacagag cggcaggggg gacgaacagc

2161 cttgcatcta gccacagaga tggaggagct ggggttggtc acccatctgg tcaccaagct

2221 ccgggccaac gtgaacgctc gcacctttgc gggaaacaca cccctgcacc tggcagctgg

2281 actggggtac ccgaccctca cccgcctcct tctgaaggct ggtgctgaca tccatgctga

2341 aaacgaggag cccctgtgcc cactgccttc accccctacc tctgatagcg actcggactc

2401 tgaagggcct gagaaggaca cccgaagcag cttccggggc cacacgcctc ttgacctcac

2461 ttgcagcacc aaggtgaaga ccttgctgct aaatgctgct cagaacacca tggagccacc

2521 cctgaccccg cccagcccag cagggccggg actgtcactt ggtgatacag ctctgcagaa

2581 cctggagcag ctgctagacg ggccagaagc ccagggcagc tgggcagagc tggcagagcg

2641 tctggggctg cgcagcctgg tagacacgta ccgacagaca acctcaccca gtggcagcct

2701 cctgcgcagc tacgagctgg ctggcgggga cctggcaggt ctactggagg ccctgtctga

2761 catgggccta gaggagggag tgaggctgct gaggggtcca gaaacccgag acaagctgcc

2821 cagcacaaca gaggtgaagg aagacagtgc gtacgggagc cagtcagtgg agcagaaggc

2881 agagaagctg ggcccacccc ctgagccacc aggagggctc tgccacgggc acccccagcc

2941 tcaggtgcac tgacctgctg cctgccccca gcccccttcc cggaccccct gtacagcgtc

3001 cccacctatt tcaaatctta tttaacaccc cacacccacc cctcagttgg gacaaataaa

3061 ggattctcat gggaagggga ggacccctcc ttcccaactt aaaaaaaaaa aaa

(2) INFORMATION FOR SEQ ID NO:2604: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13384 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2604

1 agcttcatcc tggagtcaac agattgggtt tgaatcctgg ctctgtccct ttctagctgt

61 gtgtttggtt gttactccac ctctctgagc cttaatttct tcatcagtaa aagtaatatt

121 cacctcctag ggttgttggg agggagaata agaacttcta aagtacccga acctagcaac

181 taggacacta tatttgcagg caagatgaag aggggtgggg aagtaatagg aaacagccca

241 aatcgagagc cataatagtc tctctttact tagtgccagt gcaggcctgt gattctgttc

301 ttaaaaacgt ctggggcaag ctgcaggaaa gacccgagat agcttatgtt ctaccataag

361 ccttaaggga ggaggactcc aggcagggag acttaccatg gcacctctaa gagaaagcct

421 actgaccaga gagaggtcag tcatgtactc ccgtagcttc ttagaatttc tgatctgact

481 cgctgcctct agagttgttc aggtggaaat tggaaggcta tagaggaatt cggcagcata

541 cagtggctca cgtctgtaat ccaaaatcca agcattttgg aaggccaaag taggaggatc

601 acttaagccc aggagtttaa gaccagccta ggcaaccgag tgagatccat ctccactaaa

661 aaattttaaa atttgccagg tatggtggtg tgcacctgta gccccagcta ctcaggagag

721 tcagagaatc ggcgcacccc ggagttcgag gttgcagtga gccatgatca cgccactgta

781 ctccagcctg ggtgacagag aagaccacct gtctcaaaaa acataaataa ataaataaat

841 aaataggccg tgcgcagcgg ctcacgactg taattccaac attttagaag gcggaggcag

901 cggatcacct gaggtcagga gttcgggacc agcctgacca acgtggtgaa accccaactc

961 tactaaaaat acataaatta ggcggggcgt ggtggtggcc gcctgtaatc ccagctactc

1021 ggtaggctgc agcaggagaa tggtttgaac ccgggaggca gaggttgcag tgagccaaaa

1081 tcccctcact gcattccagc ctgagactaa aaaaaagagg cgatttccca catcggtgga

1141 aatttgagct gtttaaactc tggatgcctt tttcagttct aatattccag atctccttgg

1201 tggataaaca cttcatttcc cttctcctga gcagagctcc tgagccctgg cccgctggaa

1261 cctgtcactt ctaaaaaagt tcgaggtccg gactgtctct cccggagcct tgaggctgat

1321 gagacggagc gagagagggg ccgggggcaa tggagtctac tcgcgggccc agggaggcgc

1381 cagagggccc cgggaccgac cgcaagaata acttccttcc tcttccgcta acttcccggc

1441 agggctacgc tcagggtggg ggccccgagg gctggggcgt cggcttcccc ctggggatcc

1501 cccgcttcag agaagccaag cgttagcgca gccaaagccg gaggcagcga agctccggcc

1561 cggggtggcg ctgggtcagg gtaccttctc ggcggtcccc tggccggccg aactcgcgcc

1621 tggtgtcctg tcaccccgct ccccgccctg agtgagcctg tcccctctca ggggcgcgcc

1681 cgagtcgctc cgggttggct gccaggtcca gagttaaact ttcagccaat gaaaaagggc

1741 gcgagggctg acgcacggaa acgtcatggg aattcccccc tccggggggc cgagaagggg

1801 ctttcccggc cctgagccct gctggcaggc gaggtgtcgc gaccggtccc aggtgggtcg

1861 ggcgcggaga gaagccgcaa ccagagccgc cgccacggtg agtggctgga ttcagacccc

1921 tgggtggccg ggacaagaga aaagagggag gagggccttt agcggacagc gcctggggct

1981 ggagagcagc agctgcacac agccggaaag ggcgcgcagg cgacgacact cggatccacg

2041 tcgacaccgt tgtacaaaga tacgcggacc cgtacgtaca cctgtacctg tgctggcgca

2101 cacacggcag cgtccgtgca gtcgcactcg cacacacatg cacacggaga cgtgcccacc

2161 ggtgcactgg tgcctgcacc cacacccttc acgcacaaac tcaagatacg ctcacccgtg

2221 tctgtacatc aagacaggcg ctgacacaca cccacactga gaagctcggg attcacctat

2281 ctacacacat gctcgcttgc acactcatgt tgacgccatg gacacacaac atgcaaccaa

2341 gcactacagc cgaaacacac ttgtggagct gtgatggaga cacactcttg tattaggtgg

2401 gggggggggg ggagcgtgca gagatctccc tgtcgcctgc gcgcccagaa ccggtgcggt

2461 gtgggaccag ctgctgttgt gaggtttggg agagagagaa aaagagccca ctccgaggag

2521 gagacacttt tcccgcagcc ccagaatcgc gttctcgggg cagaaccccg gggcctccca

2581 caggaaagag ccccgcctac aggctgttcg aaggggaggc cgtccgacag caggaatgtc EPI-109 774

2641 cccccaaaag cccccggggt ttatcagccg tggcctccct cctggcagaa aatcccaagg

2701 ttgctccaga ccgggggagg ggagcgggag gcggacttgg ccccagactg ccagcctcct

2761 cccggccgtg aaagaccctc ctgttccctg ccctggaggg aggagggggc ttaacccacc

2821 ggggcttccc ggattctcct agacctctgc ccgctgaaaa gcagcgggac gccgtagact

2881 gtcgagggcc atcccgcccc tcccgtcgcg agggcggggc cagtggcgtc atttccaggc

2941 ccgccccctc cggccccgcc tccccttggt attttcggga ctttcctaag ctgctctaac

3001 tttcctgccc cttccccgcc aagcccaact ccggatctcg ctctccaccg gatctcaccc

3061 gccacacccg gacaggcggc tggaggaggt cggaccctcc cccaaatctg ggcccccatt

3121 ctcccgccca cccccattta gatctgaccc cctcccccac gccactcctc ccaactttag

3181 gcgggcgtct aaaattctgg gaagcagaac ctggccggag ccactagaca gagccgggcc

3241 tagcccagag acatggagag ttgctacaac ccagtgagtc atgccgcctg cccctgaccc

3301 ggccggctag cccctcgtgt ctgtccacct gtctgcccga gccccctact gctgccttac

3361 acctgtatgc ctcgcagatg ctctcagcct gccagtctgt ccatctgtct gcaactctgc

3421 ctccaaaagg agctttctct tgggtctgag gaggaggggg gagtgaccac tgaagacttg

3481 gaagatggga ggtggggcta gtgtgggggg tgctgagagt cggatgccac ccccagtctg

3541 tctccaaacc agggtctgga tggtattatt gaatatgatg atttcaaatt gaactcctcc

3601 attgtggaac ccaaggagcc agccccagaa acaggtcagc aagttcacta acctccccta

3661 gtctaaagcg ggggagggag agcatgtgcc ctctctctgg gggaggggtc tgggagatcg

3721 tgtgctcagc aaggtctctc tgtccccagc tgatggcccc tacctggtga tcgtggaaca

3781 gcctaagcag gttgagtgag caaaagggag ggatgtggaa tggcttcagc tttggggaca

3841 aatggggtag tgtagctggc tggcatggag gagcattgcc gaagaggccc acaggggatt

3901 ggatggtcac tgctgctgat cagagtgctg tagttttggt tcagggctac taccagcgac

3961 tcgggtcact gctggcctgg gtggtcttcc ctgatcacaa tgctactatg cccttgacct

4021 tcagagaggc ttccgatttc gatatggctg tgaaggcccc tcccatggag gactgcccgg

4081 tgcctccagt gagaagggcc gaaagaccta tcccactgtc aaggtgakcc aggatggtgc

4141 tggmgggtgg gctaagtgga cagcatgccc aaggccctga cgtgacagtc ccttgcctct

4201 cctagatctg taactacgag ggaccagcca agatcgaggt ggacctggta acacacagtg

4261 acccacctcg tgctcatgcc cacagtctgg tgggcaagca atgctcggag ctggggatct

4321 gcgccgtttc tgtggggccc aaggacatga ctgcccagta ggtgcccttc ttacgccttg

4381 gcccccactg gtatgccskt cwtgccagtc ccaggcccca gccacctcca tatgatgtta

4441 gcatctgacc aaggggaaan gatgtaggtt ggccccaaac ccaagggcct aagtagaaac

4501 tccaatggct tccttgagga agtaaggctg agctgagcct ggcaatggga aaggtgcctg

4561 gcaatgggaa aggtgcctca ggaagaaaga actgcatggc caaaggctcc cgattctctc

4621 ttctcagatt taacaacctg ggtgtcctgc atgtgactaa gaagaacatg atggggacta

4681 tgatacaaaa acttcagagg cagcggctcc gctctaggcc ccagggcctt acgggtatgg

4741 gtgcaggggg tgggtcgggt atgggtgcag ggggtgggtg ggtcatggga ggtgctcatg

4801 gaaggagcag ggagggagaa gccaggggtc acacatgtac ctactgccca gaggccgagc

4861 agcgggagct ggagcaagag gccaaagaac tgaagaaggt gatggatctg agtatagtgc

4921 ggctgcgctt ctctgccttc cttagagcca gtgatggctc cttctccctg cccctgaagc

4981 cagtcacctc ccagcccatc catgatagca gtgagtatcc tgattgcctg gggtgccagg

5041 cctggtsgsa gaggtggcat gaggggtgac ctcaagctgt gcagtcaaac aagacccagg

5101 tttcagaacc tgcsctgcca catatgagct gagtgatcct gagcaagtca tttccccccc

1 ggccaccgga gcggcccggc gacgatcgct gacagcttcc cctgcccttc ccgtcggtcg

61 ggccgccagc cgccgcagcc ctcggcctgc acgcagccac cggccccgct cccggagccc

121 agcgccgccg aggccgcagc cgcccggcca gtaaggcggc gccgcccgcg gccaccgcgg

181 gccctgccgt tccctccgcc gcgctgcgcc atggcgcggc gctgactggc ctggcccggc

241 cccgccgcgc tcccgctcgc cccgacccgc actcgggccc gcccgggctc cggcctgccg

301 ccgcctcttc cttctccagc cggcaggccc cgccgcttag gagggagagc ccacccgcgc

361 caggaggccg aacgcggact cgccacccgg cttcagaatg gcagaagatg atccatattt

421 gggaaggcct gaacaaatgt ttcatttgga tccttctttg actcatacaa tatttaatcc

481 agaagtattt caaccacaga tggcactgcc aacagatggc ccataccttc aaatattaga

541 gcaacctaaa cagagaggat ttcgtttccg ttatgtatgt gaaggcccat cccatggtgg

601 actacctggt gcctctagtg aaaagaacaa gaagtcttac cctcaggtca aaatctgcaa

661 ctatgtggga ccagcaaagg ttattgttca gttggtcaca aatggaaaaa atatccacct

721 gcatgcccac agcctggtgg gaaaacactg tgaggatggg atctgcactg taactgctgg

781 acccaaggac atggtggtcg gcttcgcaaa cctgggtata cttcatgtga caaagaaaaa

841 agtatttgaa acactggaag cacgaatgac agaggcgtgt ataaggggct ataatcctgg

901 actcttggtg caccctgacc ttgcctattt gcaagcagaa ggtggagggg accggcagct

961 gggagatcgg gaaaaagagc taatccgcca agcagctctg cagcagacca aggagatgga

1021 cctcagcgtg gtgcggctca tgtttacagc ttttcttccg gatagcactg gcagcttcac

1081 aaggcgcctg gaacccgtgg tatcagacgc catctatgac agtaaagccc ccaatgcatc

1141 caacttgaaa attgtaagaa tggacaggac agctggatgt gtgactggag gggaggaaat

1201 ttatcttctt tgtgacaaag ttcagaaaga tgacatccag attcgatttt atgaagagga

1261 agaaaatggt ggagtctggg aaggatttgg agatttttcc cccacagatg ttcatagaca

1321 atttgccatt gtcttcaaaa ctccaaagta taaagatatt aatattacaa aaccagcctc

1381 tgtgtttgtc cagcttcgga ggaaatctga cttggaaact agtgaaccaa aacctttcct

1441 ctactatcct gaaatcaaag ataaagaaga agtgcagagg aaacgtcaga agctcatgcc

1501 caatttttcg gatagtttcg gcggtggtag tggtgccgga gctggaggcg gaggcatgtt EPI-109 775

1561 tggtagtggc ggtggaggag ggggcactgg aagtacaggt ccagggtata gcttcccaca 1621 ctatggattt cctacttatg gtgggattac tttccatcct ggaactacta aatctaatgc 1681 tgggatgaag catggaacca tggacactga atctaaaaag gaccctgaag gttgtgacaa 1741 aagtgatgac aaaaacactg taaacctctt tgggaaagtt attgaaacca cagagcaaga 1801 tcaggagccc agcgaggcca ccgttgggaa tggtgaggtc actctaacgt atgcaacagg 1861 aacaaaagaa gagagtgctg gagttcagga taacctcttt ctagagaagg ctatgcagct 1921 tgcaaagagg catgccaatg cccttttcga ctacgcggtg acaggagacg tgaagatgct 1981 gctggccgtc cagcgccatc tcactgctgt gcaggatgag aatggggaca gtgtcttaca 2041 cttagcaatc atccaccttc attctcaact tgtgagggat ctactagaag tcacatctgg 2101 tttgatttct gatgacatta tcaacatgag aaatgatctg taccagacgc ccttgcactt 2161 ggcagtgatc actaagcagg aagatgtggt ggaggatttg ctgagggctg gggccgacct 2221 gagccttctg gaccgcttgg gtaactctgt tttgcaccta gctgccaaag aaggacatga 2281 taaagttctc agtatcttac tcaagcacaa aaaggcagca ctacttcttg accaccccaa 2341 cggggacggt ctgaatgcca ttcatctagc catgatgagc aatagcctgc catgtttgct 2401 gctgctggtg gccgctgggg ctgacgtcaa tgctcaggag cagaagtccg ggcgcacagc 2461 actgcacctg gctgtggagc acgacaacat ctcattggca ggctgcctgc tcctggaggg 2521 tgatgcccat gtggacagta ctacctacga tggaaccaca cccctgcata tagcagctgg 2581 gagagggtcc accaggctgg cagctcttct caaagcagca ggagcagatc ccctggtgga 2641 gaactttgag cctctctatg acctggatga ctcttgggaa aatgcaggag aggatgaagg 2701 agttgtgcct ggaaccacgc ctctagatat ggccaccagc tggcaggtat ttgacatatt 2761 aaatgggaaa ccatatgagc cagagtttac atctgatgat ttactagcac aaggagacat 2821 gaaacagctg gctgaagatg tgaagctgca gctgtataag ttactagaaa ttcctgatcc 2881 agacaaaaac tgggctactc tggcgcagaa attaggtctg gggatactta ataatgcctt 2941 ccggctgagt cctgctcctt ccaaaacact tatggacaac tatgaggtct ctgggggtac 3001 agtcagagag ctggtggagg ccctgagaca aatgggctac accgaagcaa ttgaagtgat 3061 ccaggcagcc tccagcccag tgaagaccac ctctcaggcc cactcgctgc ctctctcgcc 3121 tgcctccaca aggcagcaaa tagacgagct ccgagacagt gacagtgtct gcgacacggg 3181 cgtggagaca tccttccgca aactcagctt taccgagtct ctgaccagtg gtgcctcact 3241 gctaactctc aacaaaatgc cccatgatta tgggcaggaa ggacctctag aaggcaaaat 3301 ttagcctgct gacaatttcc cacaccgtgt aaaccaaagc cctaaaattc cactgcgttg 3361 tccacaagac agaagctgaa gtgcatccaa aggtgctcag agagccggcc cgcctgaatc 3421 attctcgatt taactcgaga ccttttcaac ttggcttcct ttcttggttc ataaatgaat 3481 tttagtttgg ttcacttaca gatagtatct agcaatcaca acactggctg agcggatgca 3541 tctggggatg aggttgctta ctaagctttg ccagctgctg ctggatcaca gctgctttct 3601 gttgtcattg ctgttgtccc tctgc

1 actttcctgc cccttccccg gccaagccca actccggatc tcgctctcca ccggatctca

61 cccgccacac ccggacaggc ggctggagga ggcgggcgtc taaaattctg ggaagcagaa

121 cctggccgga gccactagac agagccgggc ctagcccaga gacatggaga gttgctacaa

181 cccaggtctg gatggtatta ttgaatatga tgatttcaaa ttgaactcct ccattgtgga

241 acccaaggag ccagccccag aaacagctga tggcccctac ctggtgatcg tggaacagcc

301 taagcagaga ggcttccga^'t ttcgatatgg ctgtgaaggc ccctcccatg gaggactgcc

361 cggtgcctcc agtgagaagg gccgaaagac ctatcccact gtcaagatct gtaactacga

421 gggaccagcc aagatcgagg tggacctggt aacacacagt gacccacctc gtgctcatgc

481 ccacagtctg gtgggcaagc aatgctcgga gctggggatc tgcgccgttt ctgtggggcc

541 caaggacatg actgcccaat ttaacaacct gggtgtcctg catgtgacta agaagaacat

601 gatggggact atgatacaaa aacttcagag gcagcggctc cgctctaggc cccagggcct

661 tacggaggcc gagcagcggg agctggagca agaggccaaa gaactgaaga aggtgatgga

721 tctgagtata gtgcggctgc gcttctctgc cttccttaga gccagtgatg gctccttctc

781 cctgcccctg aagccagtca cctcccagcc catccatgat agcaaatctc cgggggcatc

841 aaacctgaag atttctcgaa tggacaagac agcaggctct gtgcggggtg gagatgaagt

901 ttatctgctt tgtgacaagg tgcagaaaga tgacattgag gttcggttct atgaggatga

961 tgagaatgga tggcaggcct ttggggactt ctctcccaca gatgtgcata aacagtatgc

1021 cattgtgttc cggacacccc cctatcacaa gatgaagatt gagcggcctg taacagtgtt

1081 tctgcaactg aaacgcaagc gaggagggga cgtgtctgat tccaaacagt tcacctatta

1141 ccctctggtg gaagacaagg aagaggtgca gcggaagcgg aggaaggcct tgcccacctt

1201 ctcccagccc ttcgggggtg gctcccacat gggtggaggc tctgggggtg cagccggggg

1261 ctacggagga gctggaggag gtgagggggt actgatggag ggaggggtaa aggtaagaga

1321 agctgtggag gaaaaaaatc tgggggaggc cgggcgtggc ttgcacgcct gtaatccagc

1381 ctttgggagg ccaaggcagg cagttacctg agatcaggag ttcaagacca gcttggccaa

1441 cagcgtgaaa cctcgtctct actaaaaata caaacattag ctgggcatgg tggcaggcgc

1501 ctgtaatccc agctactcgg gaggctgagg caggagaatc gcttgaaccc tgggagacaa

1561 gaggttgcag taagctgaga tcacaccact gcactccagg ctgggcaata agagcgaaac

1621 tccgtctcaa aaaaaaaaaa aaaaaaaaaa

1 cacggtgagt ggctggattc agacccctgg gtggccggga caagagaaaa gagggaggag

61 ggcctttagc ggacagcgcc tggggctgga gagcagcagc tgcacacagc cggaaagggc

121 gcgcaggcga cgacactcgg atccacgtcg acaccgttgt acaaagatac gcggacccgc

181 gggcgtctaa aattctggga agcagaacct ggccggagcc actagacaga gccgggccta

241 gcccagagac atggagagtt gctacaaccc aggtctggat ggtattattg aatatgatga EPI-109 776

301 tttcaaattg aactcctcca ttgtggaacc caaggagcca gccccagaaa cagctgatgg

361 cccctacctg gtgatcgtgg aacagcctaa gcagagaggc ttccgatttc gatatggctg

421 tgaaggcccc tcccatggag gactgcccgg tgcctccagt gagaagggcc gaaagaccta

481 tcccactgtc aagatctgta actacgaggg accagccaag atcgaggtgg acctggtaac

541 acacagtgac ccacctcgtg ctcatgccca cagtctggtg ggcaagcaat gctcggagct

601 ggggatctgc gccgtttctg tggggcccaa ggacatgact gcccaattta acaacctggg

661 tgtcctgcat gtgactaagg agaacatgat ggggactatg atacaaaaac ttcagaggca

721 gcggctccgc tctaggcccc agggccttac ggaggccgag cagcgggagc tggagcaaga

781 ggccaaagaa ctgaagaagg tgatggatct gagtatagtg cggctgcgct tctctgcctt

841 ccttagagcc agtgatggct ccttctccct gcccctgaag ccagtcatct cccagcccat

901 ccatgacagc aaatctccgg gggcatcaaa cctgaagatt tctcgaatgg acaagacagc

961 aggctctgtg cggggtggag atgaagttta tctgctttgt gacaaggtgc agaaagatga

1021 cattgaggtt cggttctatg aggatgatga gaatggatgg caggcctttg gggacttctc

1081 tcccacagat gtgcataaac agtatgccat tgtgttccgg acacccccct atcacaagat

1141 gaagattgag cggcctgtaa cagtgtttct gcaactgaaa cgcaagcgag gaggggacgt

1201 gtctgattcc aaacagttca cctattaccc tctggtggaa gacaaggaag aggtgcagcg

1261 gaagcggagg aaggccttgc ccaccttctc ccagcccttc gggggtggct cccacatggg

1321 tggaggctct gggggtgcag ccgggggcta cggaggagct ggaggaggtg gcagcctcgg

1381 tttcttcccc tcctccctgg cctacagccc ctaccagtcc ggcgcgggcc ccatgggctg

1441 ctacccggga ggcgggggcg gggcgcagat ggccgccacg gtgcccagca gggactccgg

1501 ggaggaagcc gcggagccga gcgccccctc caggaccccc cagtgcgacg cgcaggcccc

1561 ggagatgctg cagcgagctc gagagtacaa cgcgcgcctg ttcggcctgg cgcagcgcag

1621 cgcccgagcc ctactcgac.t acggcgtcac cgcggaccgg cgcgcgctgc tggcgggaca

1681 gcgccacctg ctgacggcgc aggacgagaa cggagacaca ccactgcacc tagccatcat

1741 ccacgggcag accagtgtca ttgagcagat agtctatgtc atccaccacg cccaggacct

1801 cggcgttgtc aacctcacca accacctgca ccagacgccc ctgcacctgg cggtgatcac

1861 ggggcagacg agtgtggtga gctttctgct gcgggtaggt gcagacccag ctctgctgga

1921 tcggcatgga gactcagcca tgcatctggc gctgcgggca ggcgctggtg ctcctgagct

1981 gctgcgtgca ctgcttcaga gtggagctcc tgctgtgccc cagctgttgc atatgcctga

2041 ctttgaggga ctgtatccag tacacctggc ggtccgagcc cgaagccctg agtgcctgga

2101 tctgctggtg gacagtgggg ctgaagtgga ggccacagag cggcaggggg gacgaacagc

2161 cttgcatcta gccacagaga tggaggagct ggggttggtc acccatctgg tcaccaagct

2221 ccgggccaac gtgaacgctc gcacctttgc gggaaacaca cccctgcacc tggcagctgg

2281 actggggtac ccgaccctca cccgcctcct tctgaaggct ggtgctgaca tccatgctga

2341 aaacgaggag cccctgtgcc cactgccttc accccctacc tctgatagcg actcggactc

2401 tgaagggcct gagaaggaca cccgaagcag cttccggggc cacacgcctc ttgacctcac

2461 ttgcagcacc aaggtgaaga ccttgctgct aaatgctgct cagaacacca tggagccacc

2521 cctgaccccg cccagcccag cagggccggg actgtcactt ggtgatacag ctctgcagaa

2581 cctggagcag ctgctagacg ggccagaagc ccagggcagc tgggcagagc tggcagagcg

2641 tctggggctg cgcagcctgg tagacacgta ccgacagaca acctcaccca gtggcagcct

2701 cctgcgcagc tacgagctgg ctggcgggga cctggcaggt ctactggagg ccctgtctga

2761 catgggccta gaggagggag tgaggctgct gaggggtcca gaaacccgag acaagctgcc

2821 cagcacaaca gaggtgaagg aagacagtgc gtacgggagc cagtcagtgg agcagaaggc

2881 agagaagctg ggcccacccc ctgagccacc aggagggctc tgccacgggc acccccagcc

2941 tcaggtgcac tgacctgctg cctgccccca gcccccttcc cggaccccct gtacagcgtc

3001 cccacctatt tcaaatctta tttaacaccc cacacccacc cctcagttgg gacaaataaa

3061 ggattctcat gggaagggga ggacccctcc ttcccaactt aaaaaaaaaa

(2) INFORMATION FOR SEQ ID NO:2605: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2161 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2605

1 atgacagcaa aagattcttc aaaggaactt actgcttctg aacctgaggt ttgcataaag 61 actttcaagg agcaaatgca tttagaactt gagcttccga gattaccagg aaacagacct 121 acatctccta aaatttctcc acgcagttca ccaaggaact caccatgctt tttcagaaag 181 ttactggtga ataaaagcat tcggcagcgt cgtcgcttca ctgtggctca tacatgcttt 241 gatgtggaaa atggcccttc cccaggtcgg agtccactgg atccccaggc cagctcttcc 301 gctgggctgg tacttcacgc cacctttcct gggcacagcc agcgcagaga gtcatttctc 361 tacagatcag acagcgacta tgacttgtca ccaaaggcga tgtcgagaaa ctcttctctt 421 ccaagcgagc aacacggcga tgacttgatt gtaactcctt ttgcccaggt ccttgccagc 481 ttgcgaagtg tgagaaacaa cttcactata ctgacaaacc ttcatggtac atctaacaag 541 aggtccccag ctgctagtca gcctcctgtc tccagagtca acccacaaga agaatcttat 601 caaaaattag caatggaaac gctggaggaa ttagactggt gtttagacca gctagagacc 661 atacagacct accggtctgt cagtgagatg gcttctaaca agttcaaaag aatgctgaac 721 cgggagctga cacacctctc agagatgagc cgatcaggga accaggtgtc tgaatacatt EPI-109 777

781 tcaaatactt tcttagacaa gcagaatgat gtggagatcc catctcctac ccagaaagac 841 agggagaaaa agaaaaagca gcagctcatg acccagataa gtggagtgaa gaaattaatg 901 catagttcaa gcctaaacaa tacaagcatc tcacgctttg gagtcaacac tgaaaatgaa 961 gatcacctgg ccaaggagct ggaagacctg aacaaatggg gtcttaacat ctttaatgtg 1021 gctggatatt ctcacaatag acccctaaca tgcatcatgt atgctatatt ccaggaaaga 1081 gacctcctaa agacattcag aatctcatct gacacattta taacctacat gatgacttta 1141 gaagaccatt accattctga cgtggcatat cacaacagcc tgcacgctgc tgatgtagcc 1201 cagtcgaccc atgttctcct ttctacacca gcattagacg ctgtcttcac agatttggag 1261 atcctggctg ccatttttgc agctgccatc catgacgttg atcatcctgg agtctccaat 1321 cagtttctca tcaacacaaa ttcagaactt gctttgatgt ataatgatga atctgtgttg 1381 gaaaatcatc accttgctgt gggtttcaaa ctgctgcaag aagaacactg tgacatcttc 1441 atgaatctca ccaagaagca gcgtcagaca ctcaggaaga tggttattga catggtgtta 1501 gcaactgata tgtctaaaca tatgagcctg ctggcagacc tgaagacaat ggtagaaacg 1561 aagaaagtta caagttcagg cgttcttctc ctagacaact ataccgatcg cattcaggtc 1621 cttcgcaaca tggtacactg tgcagacctg agcaacccca ccaagtcctt ggaattgtat 1681 cggcaatgga cagaccgcat catggaggaa tttttccagc agggagacaa agagcgggag 1741 aggggaatgg aaattagccc aatgtgtgat aaacacacag cttctgtgga aaaatcccag 1801 gttggtttca tcgactacat tgtccatcca ttgtgggaga catgggcaga tttggtacag 1861 cctgatgctc aggacattct cgatacctta gaagataaca ggaactggta tcagagcatg 1921 atacctcaaa gtccctcacc accactggac gagcagaaca gggactgcca gggtctgatg 1981 gagaagtttc agtttgaact gactctcgat gaggaagatt ctgaaggacc tgagaaggag 2041 ggagagggac acagctattt cagcagcaca aagacgcttt gtgtgattga tccagaaaac 2101 agagattccc tgggagagac tgacatagac attgcaacag aagacaagtc ccccgtggat 2161 aca

2) INFORMATION FOR SEQ ID NO: 2606: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 301 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear ^•

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2606 1 tatcacaaca gcatgcacgc agccgatgtt acccagacag tccattgctt cttgctccgc 61 acagggatgg tgcactgcct gtcggagatt gagctcctgg ccatcatctt tgctgcagct 121 atccatgatt atgagcacac gggcactacc aacagcttcc acatccagac caagtcagaa 181 tgtgccatcg tgtacaatga tcgttcagtg ctggagaatc accacatcag ctctgttttc 241 cgattgatgc aggatgatga gatgaacatt ttcatcaacc tcaccaagga tgagtttgta 301 gaactccgag ccctggtcat tgagatggtg ttggctacag atatggca

(2) INFORMATION FOR SEQ ID NO: 2607: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2462 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2607

1 atgacagcaa aagattcttc aaaggaactt actgcttctg aacctgaggt ttgcataaag

61 actttcaagg agcaaatgca tttagaactt gagcttccga gattaccagg aaacagacct

121 acatctccta aaatttctcc acgcagttca ccaaggaact caccatgctt tttcagaaag

181 ttactggtga ataaaagcat tcggcagcgt cgtcgcttca ctgtggctca tacatgcttt

241 gatgtggaaa atggcccttc cccaggtcgg agtccactgg atccccaggc cagctcttcc

301 gctgggctgg tacttcacgc cacctttcct gggcacagcc agcgcagaga gtcatttctc

361 tacagatcag acagcgacta tgacttgtca ccaaaggcga tgtcgagaaa ctcttctctt

421 ccaagcgagc aacacggcga tgacttgatt gtaactcctt ttgcccaggt ccttgccagc

481 ttgcgaagtg tgagaaacaa cttcactata ctgacaaacc ttcatggtac atctaacaag

541 aggtccccag ctgctagtca gcctcctgtc tccagagtca acccacaaga agaatcttat

601 caaaaattag caatggaaac gctggaggaa ttagactggt gtttagacca gctagagacc

661 atacagacct accggtctgt cagtgagatg gcttctaaca agttcaaaag aatgctgaac

721 cgggagctga cacacctctc agagatgagc cgatcaggga accaggtgtc tgaatacatt

781 tcaaatactt tcttagacaa gcagaatgat gtggagatcc catctcctac ccagaaagac

841 agggagaaaa agaaaaagca gcagctcatg acccagataa gtggagtgaa gaaattaatg

901 catagttcaa gcctaaacaa tacaagcatc tcacgctttg gagtcaacac tgaaaatgaa

961 gatcacctgg ccaaggagct ggaagacctg aacaaatggg gtcttaacat ctttaatgtg

1021 gctggatatt ctcacaatag acccctaaca tgcatcatgt atgctatatt ccaggaaaga

1081 gacctcctaa agacattcag aatctcatct gacacattta taacctacat gatgacttta

1141 gaagaccatt accattctga cgtggcatat cacaacagcc tgcacgctgc tgatgtagcc

1201 cagtcgaccc atgttctcct ttctacacca gcattagacg ctgtcttcac agatttggag

1261 atcctggctg ccatttttgc agctgccatc catgacgttg atcatcctgg agtctccaat

1321 cagtttctca tcaacacaaa ttcagaactt gctttgatgt ataatgatga atctgtgttg EPI-109 778

1381 gaaaatcatc accttgctgt gggtttcaaa ctgctgcaag aagaacactg tgacatcttc

1441 atgaatctca ccaagaagca gcgtcagaca ctcaggaaga tggttattga catggtgtta

1501 gcaactgata tgtctaaaca tatgagcctg ctggcagacc tgaagacaat ggtagaaacg

1561 aagaaagtta caagttcagg cgttcttctc ctagacaact ataccgatcg cattcaggtc

1621 cttcgcaaca tggtacactg tgcagacctg agcaacccca ccaagtcctt ggaattgtat

1681 cggcaatgga cagaccgcat catggaggaa tttttccagc agggagacaa agagcgggag

1741 aggggaatgg aaattagccc aatgtgtgat aaacacacag cttctgtgga aaaatcccag

1801 gttggtttca tcgactacat tgtccatcca ttgtgggaga catgggcaga tttggtacag

1861 cctgatgctc aggacattct cgatacctta gaagataaca ggaactggta tcagagcatg

1921 atacctcaaa gtccctcacc accactggac gagcagaaca gggactgcca gggtctgatg

1981 gagaagtttc agtttgaact gactctcgat gaggaagatt ctgaaggacc tgagaaggag

2041 ggagagggac acagctattt cagcagcaca aagacgcttt gtgtgattga tccagaaaac

2101 agagattccc tgggagagac tgacatagac attgcaacag aagacaagtc ccccgtggat 2161 aca

1 tatcacaaca gcatgcacgc agccgatgtt acccagacag tccattgctt cttgctccgc

61 acagggatgg tgcactgcct gtcggagatt gagctcctgg ccatcatctt tgctgcagct

121 atccatgatt atgagcacac gggcactacc aacagcttcc acatccagac caagtcagaa

181 tgtgccatcg tgtacaatga tcgttcagtg ctggagaatc accacatcag ctctgttttc

241 cgattgatgc aggatgatga gatgaacatt ttcatcaacc tcaccaagga tgagtttgta

301 gaactccgag ccctggtcat tgagatggtg ttggctacag atatggca

(2) INFORMATION FOR SEQ ID NO: 2608: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2341 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2608

1 gggccgccgt cggcgcgctg ggtgcgggaa gggggctctg gatttcggtc cctccccttt

61 ttcctctgag tctcggaacg ctccagctct cagaccctct tcctcccagg taaaggccgg

121 gagaggaggg cgcatctctt ttccaggcac cccaccatgg gcaatgcctc caatgactcc

181 cagtctgagg actgcgagac gcgacagtgg cttcccccag gcgaaagccc agccatcagc

241 tccgtcatgt tctcggccgg ggtgctgggg aacctcatag cactggcgct gctggcgcgc

301 cgctggcggg gggacgtggg gtgcagcgcc ggccgcagga gctccctctc cttgttccac

361 gtgctggtga ccgagctggt gttcaccgac ctgctcggga cctgcctcat cagcccagtg

421 gtactggctt cgtacgcgcg gaaccagacc ctggtggcac tggcgcccga gagccgcgcg

481 tgcacctact tcgctttcgc catgaccttc ttcagcctgg ccacgatgct catgctcttc

541 gccatggccc tggagcgcta cctctcgatc gggcacccct acttctacca gcgccgcgtc

601 tcggcctccg ggggcctggc cgtgctgcct gtcatctatg cagtctccct gctcttctgc

661 tcgctgccgc tgctggacta tgggcagtac gtccagtact gccccgggac ctggtgcttc

721 atccggcacg ggcggaccgc ttacctgcag ctgtacgcca ccctgctgct gcttctcatt

781 gtctcggtgc tcgcctgcaa cttcagtgtc attctcaacc tcatccgcat gcaccgccga

841 agccggagaa gccgctgcgg accttccctg ggcagtggcc ggggcggccc cggggcccgc

901 aggagagggg aaagggtgtc catggcggag gagacggacc acctcattct cctggctatc

961 atgaccatca ccttcgccgt ctgctccttg cctttcacga tttttgcata tatgaatgaa

1021 acctcttccc gaaaggaaaa atgggacctc caagctctta ggtttttatc aattaattca

1081 ataattgacc cttgggtctt tgccatcctt aggcctcctg ttctgagact aatgcgttca

1141 gtcctctgtt gtcggatttc attaagaaca caagatgcaa cacaaacttc ctgttctaca

1201 cagtcagatg ccagtaaaca ggctgacctt tgaggtcagt agtttaaaag ttcttagtta

1261 tatagcatct ggaagatcat tttgaaattg ttccctggag aaatgaaaac agtgtgtaaa

1321 caaaatgaag ctgccctaat aaaaaggagt atacaaacat ttaagctgtg gtcaaggcta

1381 cagatgtgct gacaaggcac ttcatgtaaa gtgtcagaag gagctacaaa acctaccctc

1441 aatgagcatg gtacttggcc tttggaggaa caatcggctg cattgaagat ccagctgcct

1501 attgatttaa gctttcctgt tgaatgacaa agtatgtggt tttgtaattt gtttgaaacc

1561 ccaaacagtg actgtacttt ctattttaat cttgctacta ccgttataca catatagtgt

1621 acagccagac cagattaaac ttcatatgta atctctagga agtcaatatg tggaagcaac

1681 caagcctgct gtcttgtgat cacttagcga accctttatt tgaacaatga agttgaaaat

1741 cataggcacc ttttactgtg atgtttgtgt atgtgggagt actctcatca ctacagtatt

1801 actcttacaa gagtggactc agtgggttaa catcagtttt gtttactcat cctccaggaa

1861 ctgcaggtca agttgtcagg ttatttattt tataatgtcc atatgctaat agtgatcaag

1921 aagactttag gaatggttct ctcaacaaga aataatagaa atgtctcaag gcagttaatt

1981 ctcattaata ctcttattat cctatttctg ggggaggatg tacgtggcca tgtatgaagc

2041 caaatattag gcttaaaaac tgaaaaatct ggttcattct tcagatatac tggaaccctt

2101 ttaaagttga tattggggcc atgagtaaaa tagattttat aagatgactg tgttgtacca

2161 aaattcatct gtctatattt tatttagggg aacatggttt gactcatctt atatgggaaa

2221 ccatgtagca gtgagtcata tcttaatata tttctaaatg tttggcatgt aaatgtaaac

2281 tcagcatcaa aatatttcag tgaatttgca ctgtttaatc atagttactg tgtaaactca

2341 tctgaaatgt tacaaaaata aactataaaa ca EPI-109 779

(2) INFORMATION FOR SEQ ID NO: 2609: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1321 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2609

1 gggggcggca gggctgagcg gccggtgatg gggaccccac atcccaggca gtgccggcac

61 ccctggcgcc tgacatgagc ccttgcgggc ccctcaacct gagcctggcg ggcgaggcga

121 ccacatgcgc ggcgccctgg gtccccaaca cgtcggccgt gccgccgtcg ggcgcttcgc

181 ccgcgctgcc catcttctcc atgacgctgg gcgccgtgtc caacctgctg gcgctggcgc

241 tgctggcgca ggccgcgggc cgcctgcgac gccgccgctc ggccaccacc ttcctgctgt

301 tcgtggccag cctgctggcc accgacctgg cgggccacgt gatcccgggc gcgctggtgc

361 tgcgtctgta cactgcgggg cgcgctccgg ccggcggggc ctgccacttc ctgggcggct

421 gcatggtctt cttcggcctg tgcccgctgc tgctgggctg tggcatggcc gtggagcgct

481 gcgtgggcgt cacgcggccg ctgctccacg ccgcgcgggt ctcggtcgcc cgcgcgcgcc

541 tggcgctggc cgcggtggcc gcggtggcct tggccgtggc gctgctgccg ctggcgcgcg

601 tgggccgcta tgagctgcag tacccgggca cgtggtgctt catcggcctg ggtcccccgg

661 gcggctggcg ccaggcactg cttgctggcc tcttcgccag cctcggcctg gtcgcgctcc

721 tcgccgcgct ggtgtgcaac acgctcagcg gcctggccct gcatcgcgcc cgctggcgac

781 gccgctcccg acggcctccc ccggcctcag gccccgacag ccggcgtcgc tggggggcgc

841 acggaccccg ctcggcctcc gcctcgtccg cctcgtccat cgcttcggcc tccaccttct

901 ttggcggctc tcggagcagc ggctcggcac gcagagctcg cgcccacgac gtggagatgg

961 tgggccagct tgtcggtatc atggtggtgt cgtgcatctg ctggagccca atgctggtgt

1021 tggtggcgct ggccgtcggc ggctggagct ctacctccct gcagcggcca ctgttcctgg

1081 ccgtgcgcct tgcctcctgg aaccagatcc tggacccttg ggtgtacatc ctactgcgcc

1141 aggccgtgct gcgccaactg cttcgcctct tgcccccgag ggccggagcc aagggcggcc

1201 ccgcggggct gggcctaaca ccgagcgcct gggaggccag ctcgctgcgc agctcccggc

1261 acagcggcct cagccacttc taagcacaac cagaggccca acgactaagc cagcccaccc

1321 tgggctgggc ccaggtgcgc ggcgcagagc ctttgggaat aaaaagccat tctgcg

(2) INFORMATION FOR SEQ ID NO:2610: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1021 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2610

1 atgggcaatg cctccaatga ctcccagtct gaggactgcg agacgcgaca gtggcttccc

61 ccaggcgaaa gcccagccat cagctccgtc atgttctcgg ccggggtgct ggggaacctc

121 atagcactgg cgctgctggc gcgccgctgg cggggggacg tggggtgcag cgccggccgc

181 aggagctccc tctccttgtt ccacgtgctg gtgaccgagc tggtgttcac cgacctgctc

241 gggacctgcc tcatcagccc agtggtactg gcttcgtacg cgcggaacca gaccctggtg

301 gcactggcgc ccgagagccg cgcgtgcacc tacttcgctt tcgccatgac cttcttcagc

361 ctggccacga tgctcatgct cttcgccatg gccctggagc gctacctctc gatcgggcac

421 ccctacttct accagcgccg cgtctcgcgc tccgggggcc tggccgtgct gcctgtcatc

481 tatgcagtct ccctgctctt ctgctcgctg ccgctgctgg actatgggca gtacgtccag

541 tactgccccg ggacctggtg cttcatccgg cacgggcgga ccgcttacct gcagctgtac

601 gccaccctgc tgctgcttct cattgtctcg gtgctcgcct gcaacttcag tgtcattctc

661 aacctcatcc gcatgcaccg ccgaagccgg agaagccgct gcggaccttc cctgggcagt

721 ggccggggcg gccccggggc ccgcaggaga ggggaaaggg tgtccatggc ggaggagacg

781 gaccacctca ttctcctggc tatcatgacc atcaccttcg ccgtctgctc cttgcctttc

841 acgatttttg catatatgaa tgaaacctct tcccgaaagg aaaaatggga cctccaagct

901 cttaggtttt tatcaattaa ttcaataatt gacccttggg tctttgccat ccttaggcct

961 cctgttctga gactaatgcg ttcagtcctc tgttgtcgga tttcattaag aacacaagat

1021 gcaacacaaa cttcctgttc tacacagtca gatgccagta aacaggctga cctttga

(2) INFORMATION FOR SEQ ID NO: 2611: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1201 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2611

1 ctgcagatgg gaagaggttt ttccaggaat ttaaattgtg caataaggcc acacaatctt

61 acttaaaaaa aatggtgaag gggttttaat tacaccatga agttttacaa ttttttaggt

121 ttttagttct ggttttagaa aacagagtag aaggattaac agagaaaaac ttcaccatta

181 gacaagaagt caaaatgatt ctaagggccg cgcaaacagg ctttccaaga attaatcatg

241 aggtggtgct tggagaattc ctttactcca gtgactttga aacccccttc tcactctcca EPI-109 780

301 ctagtctttc aaaggattca tggtgaattg ggtctaacga gtataacacg gccggccgaa

361 cgatgaagct cacgctaccc tttcagggcg gagaagttcc caggaggaag aatggagaaa

421 aagatcgcag ttaggcagtc ctcccaacct caccaaggct ccacctctct ccaaagccgc

481 aacgtgctgc cacctgcgcc gggagaggct gcaatcactg tctcctcctc tttctttctc

541 tttttttttt tttctttttt gcctggggtg cccgaccaag cgcagccgca gtctgggcac

601 tgccaactga ctccaactcc ttttatggtg agaggatgga ttcttcgtta tttccccgcc

661 caatctggta cccacccacc cacccaccca ccacgtccgc tgggcgcacc caagtctaac

721 cccggggcgc acgccgtagc gcagacaccg tatttctcct cctttctcgg ccaaccctag

781 gtagaatcct aaaacaactg ccctctcttc cacgatctag atgttgcggc ccgcggacag

841 gaggttcaag aaatagtaca ctccgagcgg caggcagcga gagcggaaac ggtcgccggt

901 ttcagtggtg gccccactgg aagccgagtt caggagcggc taagcgtcgc cggggaaagc

961 accggggctt cccagggtct cctccgagtt cccactccgc acctccgagg gcgtgaaaac

1021 cacgggagcc gcccgccccg cgcgcccagc cccgccccag cccagacacc gccccccgcc

1081 agtcttccct gcggcgccca gggaggacgc cgtccgcccc cttccaatcc ggccaatggg

1141 cgcccgggca gcgcgcggtt tgcctccgcc tccgccaggg aaacttggag gaggagaaaa

1201 gtttgtacag agggtggaaa ggccgcagca cgcgagctcc a

(2) INFORMATION FOR SEQ ID NO: 2612: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2101 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2612

1 agcccggcag cccgagagga agatgaacag ccccaggcca gagcctctgc gagagtggac

61 cccgagccgc ccccaggtag ccaggagcgg cctcagcggc agccgcaaac tccagtagcc

121 gcccgtgctg cccgtgctgg ggcggagggc agccagagct ggggaccaag gctccgcgcc

181 acctgggcac agcctcacac ctgaacgctg tcctcccgca gacgagaccg gcgggcactg

241 caaagctggg actcgtcttt gaaggaaaaa aaatagcgag taagaaatcc agcaccattc

301 ttcactgacc catcccgctg cacctcttgt ttcccaagtt tttgaaagct ggcaactctg

361 acctcggtgt ccaaaaatcg acagccactg agaccggctt tgagaagccg aagatttggc

421 agtttccaga ctgagcagga caaggtgaaa gcaggttgga ggcgggtcca ggacatctga

481 gggctgaccc tgggggctcg tgaggctgcc accgctgctg ccgctacagg tgagatggcg

541 ttgggctgac gttggggtca acgggtagag aacgagggat gccgccctcg ccgaagagag

601 ccaagagggg aagagcgcgc tctccaaatt gcttttgtaa cttgttttca gtgagcattt

661 tattgattca gaatctatcg agaatagcac tagcgagcta ctttcccctt gagatgggtc

721 ttattcatct tggcaatgga gtgagttgga ttgtggggag gaagaggaat gggaaaatca

781 gtttataaat attaatgtca gccaagagtg tgctgttggc aggacgtatc gcgagcctgg

841 agattttggt ggccgcagtt ggtaagtggc tacaatccag aaagtaggat cgagttgctc

901 cccttgtctt atcagtgtat cgtttctcgg gcgcgggtct aacaccttac aagtggtaat

961 ttccgctcac ggcagctttg tctctcttct accatcccca gacccagcct tgcactccaa

1021 ggctgcgcac cgccagccac tatcatgtcc actcccgggg tcaattcgtc cgcctccttg

1081 agccccgacc ggctgaacag cccagtaacc atcccggcgg tgatgttcat cttcggggtg

1141 gtgggcaacc tggtggccat cgtggtgctg tgcaagtcgc gcaaggagca gaaggagacg

1201 accttctaca cgctggtatg tgggctggct gtcaccgacc tgttgggcac tttgttggtg

1261 agcccggtga ccatcgccac gtacatgaag ggccaatggc ccgggggcca gccgctgtgc

1321 gagtacagca ccttcattct gctcttcttc agcctgtccg gcctcagcat catctgcgcc

1381 atgagtgtcg agcgctacct ggccatcaac catgcctatt tctacagcca ctacgtggac

1441 aagcgattgg cgggcctcac gctctttgca gtctatgcgt ccaacgtgct cttttgcgcg

1501 ctgcccaaca tgggtctcgg tagctcgcgg ctgcagtacc cagacacctg gtgcttcatc

1561 gactggacca ccaacgtgac ggcgcacgcc gcctactcct acatgtacgc gggcttcagc

1621 tccttcctca ttctcgccac cgtcctctgc aacgtgcttg tgtgcggcgc gctgctccgc

1681 atgcaccgcc agttcatgcg ccgcacctcg ctgggcaccg agcagcacca cgcggccgcg

1741 gccgcctcgg ttgcctcccg gggccacccc gctgcctccc cagccttgcc gcgcctcagc

1801 gactttcggc gccgccggag cttccgccgc atcgcgggcg ccgagatcca gatggtcatc

1861 ttactcattg ccacctccct ggtggtgctc atctgctcca tcccgctcgt ggtgagtgac

1921 cgggggtggg gccctactcg gcctttttct cgcatccacc tcccgcgtcc attccccgct

1981 ccctgttttc cctctgagtc cttgggagtg aacgtgtcgc ctttaggtcg gggctgggat

2041 tcccacactg tttctcagag gaggcccaac ccctctttgg aagtcccaac cctaacgcga

2101 tttagcaggt gctttggccc tacatccccc agtttatgtt tcccggaagg ctgg

(2) INFORMATION FOR SEQ ID NO:2613: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 781 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2613

1 agcccatgac tggtttttct gaggcttatt atgtagcttc ctcttttcct ggaacttgtt EPI-109 781

61 accagaaatg aaggcagctt cctaatattg ataaggtaga catagcattt atatgttttc

121 ccaattgatt aatgatgaaa tctaaatgtg cgactcactt atgcaggtgc gagtattcgt

181 caaccagtta tatcagccaa gtttggagcg agaagtcagt aaaaatccag atttgcaggc

241 catccgaatt gcttctgtga accccatcct agacccctgg atatatatcc tcctgagaaa

301 gacagtgctc agtaaagcaa tagagaagat caaatgcctc ttctgccgca ttggcgggtc

361 ccgcagggag cgctccggac agcactgctc agacagtcaa aggacatctt ctgccatgtc

421 aggccactct cgctccttca tctcccggga gctgaaggag atcagcagta catctcagac

481 cctcctgcca gacctctcac tgccagacct cagtgaaaat ggccttggag gcaggaattt

541 gcttccaggt gtgcctggca tgggcctggc ccaggaagac accacctcac tgaggacttt

601 gcgaatatca gagacctcag actcttcaca gggtcaggac tcagagagtg tgttactggt

661 ggatgaggct ggtggaagcg gcagggcagg gcctgcccct aaggggagct ccctgcaagt

721 cacatttccc agtgaaacac tgaacttatc agaaaaatgt atataatagg caaggaaaga

781 aatacagtac tgtttctgga cccttataaa atcctgtgca atagacacat acatgtcaca

(2) INFORMATION FOR SEQ ID NO:2614: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 8766 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2614

1 gggccgccgt cggcgcgctg ggtgcgggaa gggggctctg gatttcggtc cctccccttt

61 ttcctctgag tctcggaacg ctccagctct cagaccctct tcctcccagg taaaggccgg

121 gagaggaggg cgcatctctt ttccaggcac cccaccatgg gcaatgcctc caatgactcc

181 cagtctgagg actgcgagac gcgacagtgg cttcccccag gcgaaagccc agccatcagc

241 tccgtcatgt tctcggccgg ggtgctgggg aacctcatag cactggcgct gctggcgcgc

301 cgctggcggg gggacgtggg gtgcagcgcc ggccgcagga gctccctctc cttgttccac

361 gtgctggtga ccgagctggt gttcaccgac ctgctcggga cctgcctcat cagcccagtg

421 gtactggctt cgtacgcgcg gaaccagacc ctggtggcac tggcgcccga gagccgcgcg

481 tgcacctact tcgctttcgc catgaccttc ttcagcctgg ccacgatgct catgctcttc

541 gccatggccc tggagcgcta cctctcgatc gggcacccct acttctacca gcgccgcgtc

601 tcggcctccg ggggcctggc cgtgctgcct gtcatctatg cagtctccct gctcttctgc

661 tcgctgccgc tgctggacta tgggcagtac gtccagtact gccccgggac ctggtgcttc

721 atccggcacg ggcggaccgc ttacctgcag ctgtacgcca ccctgctgct gcttctcatt

781 gtctcggtgc tcgcctgcaa cttcagtgtc attctcaacc tcatccgcat gcaccgccga

841 agccggagaa gccgctgcgg accttccctg ggcagtggcc ggggcggccc cggggcccgc

901 aggagagggg aaagggtgtc catggcggag gagacggacc acctcattct cctggctatc

961 atgaccatca ccttcgccgt ctgctccttg cctttcacga tttttgcata tatgaatgaa

1021 acctcttccc gaaaggaaaa atgggacctc caagctctta ggtttttatc aattaattca

1081 ataattgacc cttgggtctt tgccatcctt aggcctcctg ttctgagact aatgcgttca

1141 gtcctctgtt gtcggatttc attaagaaca caagatgcaa cacaaacttc ctgttctaca

1201 cagtcagatg ccagtaaaca ggctgacctt tgaggtcagt agtttaaaag ttcttagtta

1261 tatagcatct ggaagatcat tttgaaattg ttccctggag aaatgaaaac agtgtgtaaa

1321 caaaatgaag ctgccctaat aaaaaggagt atacaaacat ttaagctgtg gtcaaggcta

1381 cagatgtgct gacaaggcac ttcatgtaaa gtgtcagaag gagctacaaa acctaccctc

1441 aatgagcatg gtacttggcc tttggaggaa caatcggctg cattgaagat ccagctgcct

1501 attgatttaa gctttcctgt tgaatgacaa agtatgtggt tttgtaattt gtttgaaacc

1561 ccaaacagtg actgtacttt ctattttaat cttgctacta ccgttataca catatagtgt

1621 acagccagac cagattaaac ttcatatgta atctctagga agtcaatatg tggaagcaac

1681 caagcctgct gtcttgtgat cacttagcga accctttatt tgaacaatga agttgaaaat

1741 cataggcacc ttttactgtg atgtttgtgt atgtgggagt actctcatca ctacagtatt

1801 actcttacaa gagtggactc agtgggttaa catcagtttt gtttactcat cctccaggaa

1861 ctgcaggtca agttgtcagg ttatttattt tataatgtcc atatgctaat agtgatcaag

1921 aagactttag gaatggttct ctcaacaaga aataatagaa atgtctcaag gcagttaatt

1981 ctcattaata ctcttattat cctatttctg ggggaggatg tacgtggcca tgtatgaagc

2041 caaatattag gcttaaaaac tgaaaaatct ggttcattct tcagatatac tggaaccctt

2101 ttaaagttga tattggggcc atgagtaaaa tagattttat aagatgactg tgttgtacca

2161 aaattcatct gtctatattt tatttagggg aacatggttt gactcatctt atatgggaaa

2221 ccatgtagca gtgagtcata tcttaatata tttctaaatg tttggcatgt aaatgtaaac

2281 tcagcatcaa aatatttcag tgaatttgca ctgtttaatc atagttactg tgtaaactca

2341 tctgaaatgt tacaaaaata aactataaaa ca

1 gggggcggca gggctgagcg gccggtgatg gggaccccac atcccaggca gtgccggcac 61 ccctggcgcc tgacatgagc ccttgcgggc ccctcaacct gagcctggcg ggcgaggcga 121 ccacatgcgc ggcgccctgg gtccccaaca cgtcggccgt gccgccgtcg ggcgcttcgc 181 ccgcgctgcc catcttctcc atgacgctgg gcgccgtgtc caacctgctg gcgctggcgc 241 tgctggcgca ggccgcgggc cgcctgcgac gccgccgctc ggccaccacc ttcctgctgt 301 tcgtggccag cctgctggcc accgacctgg cgggccacgt gatcccgggc gcgctggtgc 361 tgcgtctgta cactgcgggg cgcgctccgg ccggcggggc ctgccacttc ctgggcggct 421 gcatggtctt cttcggcctg tgcccgctgc tgctgggctg tggcatggcc gtggagcgct EPI-109 782

481 gcgtgggcgt cacgcggccg ctgctccacg ccgcgcgggt ctcggtcgcc cgcgcgcgcc

541 tggcgctggc cgcggtggcc gcggtggcct tggccgtggc gctgctgccg ctggcgcgcg

601 tgggccgcta tgagctgcag tacccgggca cgtggtgctt catcggcctg ggtcccccgg

661 gcggctggcg ccaggcactg cttgctggcc tcttcgccag cctcggcctg gtcgcgctcc

721 tcgccgcgct ggtgtgcaac acgctcagcg gcctggccct gcatcgcgcc cgctggcgac

781 gccgctcccg acggcctccc ccggcctcag gccccgacag ccggcgtcgc tggggggcgc

841 acggaccccg ctcggcctcc gcctcgtccg cctcgtccat cgcttcggcc tccaccttct

901 ttggcggctc tcggagcagc ggctcggcac gcagagctcg cgcccacgac gtggagatgg

961 tgggccagct tgtcggtatc atggtggtgt cgtgcatctg ctggagccca atgctggtgt

1021 tggtggcgct ggccgtcggc ggctggagct ctacctccct gcagcggcca ctgttcctgg

1081 ccgtgcgcct tgcctcctgg aaccagatcc tggacccttg ggtgtacatc ctactgcgcc

1141 aggccgtgct gcgccaactg cttcgcctct tgcccccgag ggccggagcc aagggcggcc

1201 ccgcggggct gggcctaaca ccgagcgcct gggaggccag ctcgctgcgc agctcccggc

1261 acagcggcct cagccacttc taagcacaac cagaggccca acgactaagc cagcccaccc

1321 tgggctgggc ccaggtgcgc ggcgcagagc ctttgggaat aaaaagccat tctgcg

1 atgggcaatg cctccaatga ctcccagtct gaggactgcg agacgcgaca gtggcttccc 61 ccaggcgaaa gcccagccat cagctccgtc atgttctcgg ccggggtgct ggggaacctc 121 atagcactgg cgctgctggc gcgccgctgg cggggggacg tggggtgcag cgccggccgc 181 aggagctccc tctccttgtt ccacgtgctg gtgaccgagc tggtgttcac cgacctgctc 241 gggacctgcc tcatcagccc agtggtactg gcttcgtacg cgcggaacca gaccctggtg 301 gcactggcgc ccgagagccg cgcgtgcacc tacttcgctt tcgccatgac cttcttcagc 361 ctggccacga tgctcatgct cttcgccatg gccctggagc gctacctctc gatcgggcac 421 ccctacttct accagcgccg cgtctcgcgc tccgggggcc tggccgtgct gcctgtcatc 481 tatgcagtct ccctgctctt ctgctcgctg ccgctgctgg actatgggca gtacgtccag 541 tactgccccg ggacctggtg cttcatccgg cacgggcgga ccgcttacct gcagctgtac 601 gccaccctgc tgctgcttct cattgtctcg gtgctcgcct gcaacttcag tgtcattctc 661 aacctcatcc gcatgcaccg ccgaagccgg agaagccgct gcggaccttc cctgggcagt 721 ggccggggcg gccccggggc ccgcaggaga ggggaaaggg tgtccatggc ggaggagacg 781 gaccacctca ttctcctggc tatcatgacc atcaccttcg ccgtctgctc cttgcctttc 841 acgatttttg catatatgaa tgaaacctct tcccgaaagg aaaaatggga cctccaagct 901 cttaggtttt tatcaattaa ttcaataatt gacccttggg tctttgccat ccttaggcct 961 cctgttctga gactaatgcg ttcagtcctc tgttgtcgga tttcattaag aacacaagat 1021 gcaacacaaa cttcctgttc tacacagtca gatgccagta aacaggctga cctttga

1 ctgcagatgg gaagaggttt ttccaggaat ttaaattgtg caataaggcc acacaatctt

61 acttaaaaaa aatggtgaag gggttttaat tacaccatga agttttacaa ttttttaggt

121 ttttagttct ggttttagaa aacagagtag aaggattaac agagaaaaac ttcaccatta

181 gacaagaagt caaaatgatt ctaagggccg cgcaaacagg ctttccaaga attaatcatg

241 aggtggtgct tggagaattc ctttactcca gtgactttga aacccccttc tcactctcca

301 ctagtctttc aaaggattca tggtgaattg ggtctaacga gtataacacg gccggccgaa

361 cgatgaagct cacgctaccc tttcagggcg gagaagttcc caggaggaag aatggagaaa

421 aagatcgcag ttaggcagtc ctcccaacct caccaaggct ccacctctct ccaaagccgc

481 aacgtgctgc cacctgcgcc gggagaggct gcaatcactg tctcctcctc tttctttctc

541 tttttttttt tttctttttt gcctggggtg cccgaccaag cgcagccgca gtctgggcac

601 tgccaactga ctccaactcc ttttatggtg agaggatgga ttcttcgtta tttccccgcc

661 caatctggta cccacccacc cacccaccca ccacgtccgc tgggcgcacc caagtctaac

721 cccggggcgc acgccgtagc gcagacaccg tatttctcct cctttctcgg ccaaccctag

781 gtagaatcct aaaacaactg ccctctcttc cacgatctag atgttgcggc ccgcggacag

841 gaggttcaag aaatagtaca ctccgagcgg caggcagcga gagcggaaac ggtcgccggt

901 ttcagtggtg gccccactgg aagccgagtt caggagcggc taagcgtcgc cggggaaagc

961 accggggctt cccagggtct cctccgagtt cccactccgc acctccgagg gcgtgaaaac

1021 cacgggagcc gcccgccccg cgcgcccagc cccgccccag cccagacacc gccccccgcc

1081 agtcttccct gcggcgccca gggaggacgc cgtccgcccc cttccaatcc ggccaatggg

1141 cgcccgggca gcgcgcggtt tgcctccgcc tccgccaggg aaacttggag gaggagaaaa

1201 gtttgtacag agggtggaaa ggccgcagca cgcgagctcc a

1 agcccggcag cccgagagga agatgaacag ccccaggcca gagcctctgc gagagtggac 61 cccgagccgc ccccaggtag ccaggagcgg cctcagcggc agccgcaaac tccagtagcc 121 gcccgtgctg cccgtgctgg ggcggagggc agccagagct ggggaccaag gctccgcgcc 181 acctgggcac agcctcacac ctgaacgctg tcctcccgca gacgagaccg gcgggcactg 241 caaagctggg actcgtcttt gaaggaaaaa aaatagcgag taagaaatcc agcaccattc 301 ttcactgacc catcccgctg cacctcttgt ttcccaagtt tttgaaagct ggcaactctg 361 acctcggtgt ccaaaaatcg acagccactg agaccggctt tgagaagccg aagatttggc 421 agtttccaga ctgagcagga caaggtgaaa gcaggttgga ggcgggtcca ggacatctga 481 gggctgaccc tgggggctcg tgaggctgcc accgctgctg ccgctacagg tgagatggcg 541 ttgggctgac gttggggtca acgggtagag aacgagggat gccgccctcg ccgaagagag 601 ccaagagggg aagagcgcgc tctccaaatt gcttttgtaa cttgttttca gtgagcattt 661 tattgattca gaatctatcg agaatagcac tagcgagcta ctttcccctt gagatgggtc 721 ttattcatct tggcaatgga gtgagttgga ttgtggggag gaagaggaat gggaaaatca 781 gtttataaat attaatgtca gccaagagtg tgctgttggc aggacgtatc gcgagcctgg EPI-109 783

841 agattttggt ggccgcagtt ggtaagtggc tacaatccag aaagtaggat cgagttgctc

901 cccttgtctt atcagtgtat cgtttctcgg gcgcgggtct aacaccttac aagtggtaat

961 ttccgctcac ggcagctttg tctctcttct accatcccca gacccagcct tgcactccaa

1021 ggctgcgcac cgccagccac tatcatgtcc actcccgggg tcaattcgtc cgcctccttg

1081 agccccgacc ggctgaacag cccagtaacc atcccggcgg tgatgttcat cttcggggtg

1141 gtgggcaacc tggtggccat cgtggtgctg tgcaagtcgc gcaaggagca gaaggagacg

1201 accttctaca cgctggtatg tgggctggct gtcaccgacc tgttgggcac tttgttggtg

1261 agcccggtga ccatcgccac gtacatgaag ggccaatggc ccgggggcca gccgctgtgc

1321 gagtacagca ccttcattct gctcttcttc agcctgtccg gcctcagcat catctgcgcc

1381 atgagtgtcg agcgctacct ggccatcaac catgcctatt tctacagcca ctacgtggac

1441 aagcgattgg cgggcctcac gctctttgca gtctatgcgt ccaacgtgct cttttgcgcg

1501 ctgcccaaca tgggtctcgg tagctcgcgg ctgcagtacc cagacacctg gtgcttcatc

1561 gactggacca ccaacgtgac ggcgcacgcc gcctactcct acatgtacgc gggcttcagc

1621 tccttcctca ttctcgccac cgtcctctgc aacgtgcttg tgtgcggcgc gctgctccgc

1681 atgcaccgcc agttcatgcg ccgcacctcg ctgggcaccg agcagcacca cgcggccgcg

1741 gccgcctcgg ttgcctcccg gggccacccc gctgcctccc cagccttgcc gcgcctcagc

1801 gactttcggc gccgccggag cttccgccgc atcgcgggcg ccgagatcca gatggtcatc

1861 ttactcattg ccacctccct ggtggtgctc atctgctcca tcccgctcgt ggtgagtgac

1921 cgggggtggg gccctactcg gcctttttct cgcatccacc tcccgcgtcc attccccgct

1981 ccctgttttc cctctgagtc cttgggagtg aacgtgtcgc ctttaggtcg gggctgggat

2041 tcccacactg tttctcagag gaggcccaac ccctctttgg aagtcccaac cctaacgcga

2101 tttagcaggt gctttggccc tacatccccc agtttatgtt tcccggaagg ctgg

1 agcccatgac tggtttttct gaggcttatt atgtagcttc ctcttttcct ggaacttgtt

61 accagaaatg aaggcagctt cctaatattg ataaggtaga catagcattt atatgttttc

121 ccaattgatt aatgatgaaa tctaaatgtg cgactcactt atgcaggtgc gagtattcgt

181 caaccagtta tatcagccaa gtttggagcg agaagtcagt aaaaatccag atttgcaggc

241 catccgaatt gcttctgtga accccatcct agacccctgg atatatatcc tcctgagaaa

301 gacagtgctc agtaaagcaa tagagaagat caaatgcctc ttctgccgca ttggcgggtc

361 ccgcagggag cgctccggac agcactgctc agacagtcaa aggacatctt ctgccatgtc

421 aggccactct cgctccttca tctcccggga gctgaaggag atcagcagta catctcagac

481 cctcctgcca gacctctcac tgccagacct cagtgaaaat ggccttggag gcaggaattt

541 gcttccaggt gtgcctggca tgggcctggc ccaggaagac accacctcac tgaggacttt

601 gcgaatatca gagacctcag actcttcaca gggtcaggac tcagagagtg tgttactggt

661 ggatgaggct ggtggaagcg gcagggcagg gcctgcccct aaggggagct ccctgcaagt

721 cacatttccc agtgaaacac tgaacttatc agaaaaatgt atataatagg caaggaaaga

781 aatacagtac tgtttctgga cccttataaa atcctgtgca atagacacat acatgtcaca

(2) INFORMATION FOR SEQ ID NO: 2615: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4861 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2615

1 aagcttcctg tacctggaat attaatattt tatttcagat ttgggaaatt ttcagctagc

61 aatctttaaa tatgctttct gacccccttt tcctctattt tctccttctt aaactactgt

121 aatgtgaaca ttagctctct tttttaattt ttaatttaat ttttgttttt attttttgag

181 atgcagtctc actctgtcac ccaggctgga gtgcagtggc atgatctcag ctcactgcaa

241 cctttgcctt ctaggttgaa gagattctgc tgcctcagtc tccccatgag ctgggattac

301 agcatgtgcc acaatccctg gctaattttt ttgtattttt agtagagact gggtttcacc

361 atgttggtca ggctggtctt gactcctgac ctcaggtgat ccactcacct tggcctccca

421 aagcgctggg attatggcat gagccactga gtctggctga atgttagctc tcttgatgct

481 gtcccataaa tcttgtaggc tttcatcatt tcttttcatt cttttttctc ctctcactgt

541 atattttcaa aaacctgtct tcagttcaca gattctttct tctgcttgat caagtctgct

601 actggtgatt tctactgcat ttctcacttc attcattata tttttcagct ccaatttctt

661 ttatgatttc aatctttctg ttacatttct tatgttgtgc atttattgtt tctctgattt

721 caccaaattg tttctctgtg tttgcttcaa agtaactgag cttctttaaa aacaattatc

781 ttgaatccat tgtcaggcca tttgtagtac tccatttctt ttgggtcagc tactgggaaa

841 ttattgtgtt tcttaggtgg tgatatttta atttgggttt tcatgtttct tgctgcctta

901 cactgctgtc tgagcatctg gtggatctgc cccaatttca ggctgtatgg gctgactttg

961 gtggagaaat accttcttat gtggaataat gcgaggatgc tggctgggtg ggatgcaaaa

1021 gttctgactt cagtaggggc aaagctgtgt ggtctccatg cagatctgtc agctgaggtt

1081 ggtgttagtg aatactacag ggatccttag aggccaacac tgtgggtatc tacagtggca

1141 atgaggctgt tgaggttttc aattgtgaca agtcctccat atctcttttt ttccccacct

1201 gggaagtcat gactgaggac atccctcttg gaattaggtc taacttgcag gcctgctcct

1261 ggtggtggtg acactggtgt ctgatgaaca gtgcccatgg agtggccaag agccaaggcc

1321 tgaagcatgg gcatgcatgg agggaccaca gcaccagatt caattgtagc aatggtacca

1381 gtgcccaagg cacaggcata cttactatca cattgataat ggtgtgtaaa atgcaggtac EPI-109 784

1441 ttataaagca gctaaggagc cagggacttt actgcatgca tacgcagagc tacagtggct 1501 ccaggatcca gggtgtgggc tagctctcct tggtggctga gctggtgact agagcatgga 1561 caggcacaga gaaaccttga ctctaggacc cagggtgttc actagctcac tatagtggtg 1621 gctctggtgt tggaggtgtg ggtgtgtgta gtacagcctc agagacaggg tctggagcgc 1681 aggtgtgcac attactacag cagctctgga gttgagaata tgggttacct ttctacagtg 1741 gctgaactag tgtctggagc aaagactttc acagagagaa cttggcttgg ggtcccaggg 1801 tgagatctag ttcacaacag cagtgactcc agtgtctgag acatgaggag gtgcactgca 1861 gccacagagc cacagtccag agtgtgaata tctgtagagc agccacaact tttggggatc 1921 aggaacacac atagaattgt gagaggtggt aaccctggcc ccagtcctgg cgagtgcaac 1981 aatagctgct tcttggtgag ggggtgtgag gggtagtgca actgtgtttc cctttttagc 2041 atcctgctat gggaatggct gttggacaaa agatgccagt gtcctctgtg gagcaggaca 2101 ctgggggcct cagtggctct gtgtcacatg actgacacag atagcctaca aatttcttta 2161 ttcgtagcta tctcctggtg tctcatatat gccagtctca ccggtgattc ttctacatga 2221 atattctttc ttttctccat tgtgttgttc caaattcttt aacaggctct tgagccccat 2281 cccccaactc cccacccttg tgagggctat tttggtttgt gtataactgt ctatgtttgt 2341 ttttttgttg gggcataagg ctgacatctc ctactccacc atcttgctaa tgtcacctgc 2401 ataggaatct ttttatgctt tccttatatt cactaaaatt taacaatatc aaacttaaaa 2461 acatatgatc aattgaactt attaatatca aacttattat aaataagaaa ctaccaggct 2521 gggcatggtg gctcatgcct gtaatcccaa cattttggga ggctgaggtg aaaggatcac 2581 ttgagcccag gaattcaaga ccagcctggg aaatatagag agaccctatc tctagagatt 2641 ttttttttta attagccagt agtgatggca cacatctata gtcccagcta ctcaggaggc 2701 tgaggtggga gaattgcttg agcccaggag gtcaaggctg cagcaagcag taatcatgcc 2761 actgcactcc agcctgggcc gcagagtgag accctgtctc aaaaaaagaa cctactagtc 2821 tacataccac acttcttcat ccccatctga gactatatat attttttcta acatgaggca 2881 atgccaaaaa gaggagctgg tgagtgaaag taagaacaga aagacatgga ggcaagtctt 2941 atagaataat agccaacact taaacttaca cttaacagcg tgataggtat tgttccaaac 3001 acattaaatt catttaatgg tccttacatg tctatgtatt tggtgattat tatccttatt 3061 attcacattg ctgagtgtat tattctgttc tcatgatgct gatagagaca tacccgagac 3121 tggataactt attaaaaaaa aaaaggttta atggactcac agttccacgt ggatggggag 3181 tcctcacaat catggtagaa agcaaaagac acgtcttaca tggcagcagg gaagagagag 3241 aaatgagaac caaacaaaag gggtttcccc ttataaaacc atcagctctc atgcgactta 3301 ttcactacca tgagaacagt atgggggaaa ccacccccat gattcaatga tctaccaggt 3361 gcctcccaca acctgtggga attatgggag ctacaattcc agatgagatt tgggtgggga 3421 cacagccaaa ccacatcact gaggaaactg agttataggg agattagtaa cgcccaacac 3481 agctggtagg tggtggagcc aggcagtctg actctagggt ctggactctg aactgcatca 3541 tgctgccaag aagttcctca ttttttcctc tctctaagtt tcccttattc ccctacagtc 3601 attccttcaa cagcatttcc ttcaccatct tttctacttc tactatataa ttaatttttt 3661 cttcttggtc ccaaattcca acgtgcaaat gcagccttat ataccctaat tcatctttac 3721 ctttagactt tcttccaatg tttctacttc attccatttt aaatttatcc atgagatgcc 3781 tatttacaag ctgtaaccat catgaagtga atgaagaata atacctacta ctgtacaata 3841 gaattccaag agtataaata ggagttatgg ctttctgact tgaaactaaa tacttgatac 3901 ttgattttgc tgtctgagat caatctgaaa agtaataata atcactaaca tttgttgagc 3961 atcaattgtg ggccaagtgt catttcaatc actctgtaca tattaactca tttcatccta 4021 caacaacccg gtgaggcaag ttctgttatt ctgttttaca gttgaggaaa cagaggcata 4081 gagagcttaa gtagtttgcc cagtagatag ccagaagagg agccagσatg ggtctcgggc 4141 agtttaacag cacagctgaa gtcttaacca ctatgccaac agctttttgg tcctacacat 4201 cccatgggaa gaggaaaata aaaaggtatc tatttgtata cctttttatt tctgatataa 4261 gaagcagaat tcctttcaca tgacctatgt ctatttaata cgtcattttg aaacttacca 4321 ataaaatttc ccaagcgcca gaaaactgtt agtggctttt tccattcttc tctatttttt 4381 tttgtgctac taattttgct tctttccctc agaaggctgc cggaatagta aacattcact 4441 gacatgtcat aattactgga aaatgggcac tggaaaatca cattgtaatt aattcaaagc 4501 atgttttcca aatgtactac tttaaattgg agcttatatc ataatccaag gaaacctttg 4561 tgtgtgtact gttcccacat tgctcagcct gggatatcca ggagtaattc accttgcgcc 4621 tgcctccaga ccatcttcca tggaaggggg tgaccccttg cctcttggca accactattt 4681 ctaagctgcc aacattactc ttgcattatc aacattctaa cttcatggga agggctgtgg 4741 tgagtttctg gaatgtgaat aggaagttgt ttttctaaac agcctgacac tgaggggagg 4801 cagtgagact gtaagcagtc tgggttgggc agaaggcaga aaaccagcag agtcacagag 4861 gagatg

(2) INFORMATION FOR SEQ ID NO:2616: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 961 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2616

1 gtcgaggatc cctaaagtcc tttgaagctt tcatattctg taacttttgt gccaagaagg

61 ccttacagtg agatgggatc ccagtattta ttgagtttcc tcattcataa aatggggata

121 ataatagtaa atgagttgac acgcgctaag acagtggaat agtggctggc acagataagc EPI-109 785

181 cctcggtaaa tggtagccaa taatgataga gtatgctgta agatatcttt ctctccctct 241 gcttctcaac aagtctctaa tcaattattc cactttataa acaaggaaat agaactcaaa 301 gacattaagc acttttccaa aggtcgctta gcaagtaaat gggagagacc ctatgaccag 361 gatgaaagca agaaattccc acaagaggac tcattccaac tcatatcttg tgaaaaggtt 421 cccaatgccc agctcagatc aactgcctca atttacagtg tgagtgtgct cacctccttt 481 ggggactgta tatccagagg accctcctca ataaaacact ttataaataa catccttcca 541 tggatgaggg aaaggaggta agatctgtaa tgaataagca ggaactttga agactcagtg 601 actcagtgag taataaagac tcagtgactt ctgatcctgt cctaactgcc actccttgtt 661 gtcccaagaa agcggcttcc tgctctctga ggaggacccc ttccctggaa ggtaaaacta 721 aggatgtcag cagagaaatt tttccaccat tggtgcttgg tcaaagagga aactgatgag 781 ctcactctag atgagagagc agtgagggag agacagagac tcgaatttcc ggagctattt 841 cagttttctt ttccgttttg tgcaatttca cttatgatac cggccaatgc ttggttgcta 901 ttttggaaac tccccttagg ggatgcccct caactggccc tataaagggc cagcctgagc 961 tgcagaggat caagacagca cgtggacctc gcacagcctc tcccacaggt accatg

(2) INFORMATION FOR SEQ ID NO: 2617: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1141 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2617

1 cctccgacag cctctccaca ggtaccatga aggtctccgc ggcacgcctc gctgtcatcc

61 tcattgctac tgccctctgc gctcctgcat ctgcctcccc atattcctcg gacaccacac

121 cctgctgctt tgcctacatt gcccgcccac tgccccgtgc ccacatcaag gagtatttct

181 acaccagtgg caagtgctcc aacccagcag tcgtctttgt cacccgaaag aaccgccaag

241 tgtgtgccaa cccagagaag aaatgggttc gggagtacat caactctttg gagatgagct

301 aggatggaga gtccttgaac ctgaacttac acaaatttgc ctgtttctgc ttgctcttgt

361 cctagcttgg gaggcttccc ctcactatcc taccccaccc gctccttgaa gggcccagat

421 tctgaccacg acgagcagca gttacaaaaa ccttccccag gctggacgtg gtggctcagc

481 cttgtaatcc cagcactttg ggaggccaag gtgggtggat cacttgaggt caggagttcg

541 agacagcctg gccaacatga tgaaacccca tgtgtactaa aaatacaaaa aattagccgg

601 gcgtggtagc gggcgcctgt agtcccagct actcgggagg ctgaggcagg agaatggcgt

661 gaacccggga gcggagcttg cagtgagccg agatcgcgcc actgcactcc agcctgggcg

721 acagagcgag actccgtctc aaaaaaaaaa aaaaaaaaaa aaaaaataca aaaattagcc

781 gcgtggtggc ccacgcctgt aatcccagct actcgggagg ctaaggcagg aaaattgttt

841 gaacccagga ggtggaggct gcagtgagct gagattgtgc cacttcactc cagcctgggt

901 gacaaagtga gactccgtca caacaacaac aacaaaaagc ttccccaact aaagcctaga

961 agagcttctg aggcgctgct ttgtcaaaag gaagtctcta ggttctgagc tctggctttg

1021 ccttggcttt gcaagggct.c tgtgacaagg aaggaagtca gcatgcctct agaggcaagg

1081 aagggaggaa cactgcactc ttaagcttcc gccgtctcaa cccctcacag gagcttactg

1141 gcaaacatga aaaatcgggg

(2) INFORMATION FOR SEQ ID NO: 2618: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2102 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2618

1 gtcgaggatc cctaaagtcc tttgaagctt tcatattctg taacttttgt gccaagaagg

61 ccttacagtg agatgggatc ccagtattta ttgagtttcc tcattcataa aatggggata

121 ataatagtaa atgagttgac acgcgctaag acagtggaat agtggctggc acagataagc

181 cctcggtaaa tggtagccaa taatgataga gtatgctgta agatatcttt ctctccctct

241 gcttctcaac aagtctctaa tcaattattc cactttataa acaaggaaat agaactcaaa

301 gacattaagc acttttccaa aggtcgctta gcaagtaaat gggagagacc ctatgaccag

361 gatgaaagca agaaattccc acaagaggac tcattccaac tcatatcttg tgaaaaggtt

421 cccaatgccc agctcagatc aactgcctca atttacagtg tgagtgtgct cacctccttt

481 ggggactgta tatccagagg accctcctca ataaaacact ttataaataa catccttcca

541 tggatgaggg aaaggaggta agatctgtaa tgaataagca ggaactttga agactcagtg

601 actcagtgag taataaagac tcagtgactt ctgatcctgt cctaactgcc actccttgtt

661 gtcccaagaa agcggcttcc tgctctctga ggaggacccc ttccctggaa ggtaaaacta

721 aggatgtcag cagagaaatt tttccaccat tggtgcttgg tcaaagagga aactgatgag

781 ctcactctag atgagagagc agtgagggag agacagagac tcgaatttcc ggagctattt

841 cagttttctt ttccgttttg tgcaatttca cttatgatac cggccaatgc ttggttgcta

901 ttttggaaac tccccttagg ggatgcccct caactggccc tataaagggc cagcctgagc

961 tgcagaggat caagacagca cgtggacctc gcacagcctc tcccacaggt accatg

1 cctccgacag cctctccaca ggtaccatga aggtctccgc ggcacgcctc gctgtcatcc

61 tcattgctac tgccctctgc gctcctgcat ctgcctcccc atattcctcg gacaccacac EPI-109 786

121 cctgctgctt tgcctacatt gcccgcccac tgccccgtgc ccacatcaag gagtatttct

181 acaccagtgg caagtgctcc aacccagcag tcgtctttgt cacccgaaag aaccgccaag

241 tgtgtgccaa cccagagaag aaatgggttc gggagtacat caactctttg gagatgagct

301 aggatggaga gtccttgaac ctgaacttac acaaatttgc ctgtttctgc ttgctcttgt

361 cctagcttgg gaggcttccc ctcactatcc taccccaccc gctccttgaa gggcccagat

421 tctgaccacg acgagcagca gttacaaaaa ccttccccag gctggacgtg gtggctcagc

481 cttgtaatcc cagcactttg ggaggccaag gtgggtggat cacttgaggt caggagttcg

541 agacagcctg gccaacatga tgaaacccca tgtgtactaa aaatacaaaa aattagccgg

601 gcgtggtagc gggcgcctgt agtcccagct actcgggagg ctgaggcagg agaatggcgt

661 gaacccggga gcggagcttg cagtgagccg agatcgcgcc actgcactcc agcctgggcg

721 acagagcgag actccgtctc aaaaaaaaaa aaaaaaaaaa aaaaaataca aaaattagcc

781 gcgtggtggc ccacgcctgt aatcccagct actcgggagg ctaaggcagg aaaattgttt

841 gaacccagga ggtggaggct gcagtgagct gagattgtgc cacttcactc cagcctgggt

901 gacaaagtga gactccgtca caacaacaac aacaaaaagc ttccccaact aaagcctaga

961 agagcttctg aggcgctgct ttgtcaaaag gaagtctcta ggttctgagc tctggctttg

1021 ccttggcttt gcaagggctc tgtgacaagg aaggaagtca gcatgcctct agaggcaagg

1081 aagggaggaa cactgcactc ttaagcttcc gccgtctcaa cccctcacag gagcttactg

1141 gcaaacatga aaaatcgggg

(2) INFORMATION FOR SEQ ID NO: 2619: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3961 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2619

1 attaaacctc tcgccgagcc cctccgcaga ctctgcgccg gaaagtttca tttgctgtat

61 gccatcctcg agagctgtct aggttaacgt tcgcactctg tgtatataac ctcgacagtc

121 ttggcaccta acgtgctgtg cgtagctgct cctttggttg aatccccagg cccttgttgg

181 ggcacaaggt ggcaggatgt ctcagtggta cgaacttcag cagcttgact caaaattcct

241 ggagcaggtt caccagcttt atgatgacag ttttcccatg gaaatcagac agtacctggc

301 acagtggtta gaaaagcaag actgggagca cgctgccaat gatgtttcat ttgccaccat

361 ccgttttcat gacctcctgt cacagctgga tgatcaatat agtcgctttt ctttggagaa

421 taacttcttg ctacagcata acataaggaa aagcaagcgt aatcttcagg ataattttca

481 ggaagaccca atccagatgt ctatgatcat ttacagctgt ctgaaggaag aaaggaaaat

541 tctggaaaac gcccagagat ttaatcaggc tcagtcgggg aatattcaga gcacagtgat

601 gttagacaaa cagaaagagc ttgacagtaa agtcagaaat gtgaaggaca aggttatgtg

661 tatagagcat gaaatcaaga gcctggaaga tttacaagat gaatatgact tcaaatgcaa

721 aaccttgcag aacagagaac acgagaccaa tggtgtggca aagagtgatc agaaacaaga

781 acagctgtta ctcaagaaga tgtatttaat gcttgacaat aagagaaagg aagtagttca

841 caaaataata gagttgctga atgtcactga acttacccag aatgccctga ttaatgatga

901 actagtggag tggaagcgga gacagcagag cgcctgtatt ggggggccgc ccaatgcttg

961 cttggatcag ctgcagaact ggttcactat agttgcggag agtctgcagc aagttcggca

1021 gcagcttaaa aagttggagg aattggaaca gaaatacacc tacgaacatg accctatcac

1081 aaaaaacaaa caagtgttat gggaccgcac cttcagtctt ttccagcagc tcattcagag

1141 ctcgtttgtg gtggaaagac agccctgcat gccaacgcac cctcagaggc cgctggtctt

1201 gaagacaggg gtccagttca ctgtgaagtt gagactgttg gtgaaattgc aagagctgaa

1261 ttataatttg aaagtcaaag tcttatttga taaagatgtg aatgagagaa atacagtaaa

1321 aggatttagg aagttcaaca ttttgggcac gcacacaaaa gtgatgaaca tggaggagtc

1381 caccaatggc agtctggcgg ctgaatttcg gcacctgcaa ttgaaagaac agaaaaatgc

1441 tggcaccaga acgaatgagg gtcctctcat cgttactgaa gagcttcact cccttagttt

1501 tgaaacccaa ttgtgccagc ctggtttggt aattgacctc gagacgacct ctctgcccgt

1561 tgtggtgatc tccaacgtca gccagctccc gagcggttgg gcctccatcc tttggtacaa

1621 catgctggtg gcggaaccca ggaatctgtc cttcttcctg actccaccat gtgcacgatg

1681 ggctcagctt tcagaagtgc tgagttggca gttttcttct gtcaccaaaa gaggtctcaa

1741 tgtggaccag ctgaacatgt tgggagagaa gcttcttggt cctaacgcca gccccgatgg

1801 tctcattccg tggacgaggt tttgtaagga aaatataaat gataaaaatt ttcccttctg

1861 gctttggatt gaaagcatcc tagaactcat taaaaaacac ctgctccctc tctggaatga

1921 tgggtgcatc atgggcttca tcagcaagga gcgagagcgt gccctgttga aggaccagca

1981 gccggggacc ttcctgctgc ggttcagtga gagctcccgg gaaggggcca tcacattcac

2041 atgggtggag cggtcccaga acggaggcga acctgacttc catgcggttg aaccctacac

2101 gaagaaagaa ctttctgctg ttactttccc tgacatcatt cgcaattaca aagtcatggc

2161 tgctgagaat attcctgaga atcccctgaa gtatctgtat ccaaatattg acaaagacca

2221 tgcctttgga aagtattact ccaggccaaa ggaagcacca gagccaatgg aacttgatgg

2281 ccctaaagga actggatata tcaagactga gttgatttct gtgtctgaag ttcacccttc

2341 tagacttcag accacagaca acctgctccc catgtctcct gaggagtttg acgaggtgtc

2401 tcggatagtg ggctctgtag aattcgacag tatgatgaac acagtataga gcatgaattt

2461 ttttcatctt ctctggcgac agttttcctt ctcatctgtg attccctcct gctactctgt EPI-109 787

2521 tccttcacat cctgtgtttc tagggaaatg aaagaaaggc cagcaaattc gctgcaacct 2581 gttgatagca agtgaatttt tctctaactc agaaacatca gttactctga agggcatcat 2641 gcatcttact gaaggtaaaa ttgaaaggca ttctctgaag agtgggtttc acaagtgaaa 2701 aacatccaga tacacccaaa gtatcaggac gagaatgagg gtcctttggg aaaggagaag 2761 ttaagcaaca tctagcaaat gttatgcata aagtcagtgc ccaactgtta taggttgttg 2821 gataaatcag tggttattta gggaactgct tgacgtagga acggtaaatt tctgtgggag 2881 aattcttaca tgttttcttt gctttaagtg taactggcag ttttccattg gtttacctgt 2941 gaaatagttc aaagccaagt ttatatacaa ttatatcagt cctctttcaa aggtagccat 3001 catggatctg gtagggggaa aatgtgtatt ttattacatc tttcacattg gctatttaaa 3061 gacaaagaca aattctgttt cttgagaaga gaatattagc tttactgttt gttatggctt 3121 aatgacacta gctaatatca atagaaggat gtacatttcc aaattcacaa gttgtgtttg 3181 atatccaaag ctgaatacat tctgctttca tcttggtcac atacaattat ttttacagtt 3241 ctcccaaggg agttaggcta ttcacaacca ctcattcaaa agttgaaatt aaccatagat 3301 gtagataaac tcagaaattt aattcatgtt tcttaaatgg gctactttgt cctttttgtt 3361 attagggtgg tatttagtct attagccaca aaattgggaa aggagtagaa aaagcagtaa 3421 ctgacaactt gaataataca ccagagataa tatgagaatc agatcatttc aaaactcatt 3481 tcctatgtaa ctgcattgag aactgcatat gtttcgctga tatatgtgtt tttcacattt 3541 gcgaatggtt ccattctctc tcctgtactt tttccagaca cttttttgag tggatgatgt 3601 ttcgtgaagt atactgtatt tttacctttt tccttcctta tcactgacac aaaaagtaga 3661 ttaagagatg ggtttgacaa ggttcttccc ttttacatac tgctgtctat gtggctgtat 3721 cttgtttttc cactactgct accacaacta tattatcatg caaatgctgt attcttcttt 3781 ggtggagata aagatttctt gagttttgtt ttaaaattaa agctaaagta tctgtattgc 3841 attaaatata atatcgacac agtgctttcc gtggcactgc atacaatctg aggcctcctc 3901 tctcagtttt tatatagatg gcgagaacct aagtttcagt tgattttaca attgaaatga 3961 ctaaaaaaca aagaagacaa cattaaaaac aatattgttt eta

(2) INFORMATION FOR SEQ ID NO:2620: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2581 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2620

1 attaaacctc tcgccgagcc cctccgcaga ctctgcgccg gaaagtttca tttgctgtat

61 gccatcctcg agagctgtct aggttaacgt tcgcactctg tgtatataac ctcgacagtc

121 ttggcaccta acgtgctgtg cgtagctgct cctttggttg aatccccagg cccttgttgg

181 ggcacaaggt ggcaggatgt ctcagtggta cgaacttcag cagcttgact caaaattcct

241 ggagcaggtt caccagcttt atgatgacag ttttcccatg gaaatcagac agtacctggc

301 acagtggtta gaaaagcaag actgggagca cgctgccaat gatgtttcat ttgccaccat

361 ccgttttcat gacctcctgt cacagctgga tgatcaatat agtcgctttt ctttggagaa

421 taacttcttg ctacagcata acataaggaa aagcaagcgt aatcttcagg ataattttca

481 ggaagaccca atccagatgt ctatgatcat ttacagctgt ctgaaggaag aaaggaaaat

541 tctggaaaac gcccagagat ttaatcaggc tcagtcgggg aatattcaga gcacagtgat

601 gttagacaaa cagaaagagc ttgacagtaa agtcagaaat gtgaaggaca aggttatgtg

661 tatagagcat gaaatcaaga gcctggaaga tttacaagat gaatatgact tcaaatgcaa

721 aaccttgcag aacagagaac acgagaccaa tggtgtggca aagagtgatc agaaacaaga

781 acagctgtta ctcaagaaga tgtatttaat gcttgacaat aagagaaagg aagtagttca

841 caaaataata gagttgctga atgtcactga acttacccag aatgccctga ttaatgatga

901 actagtggag tggaagcgga gacagcagag cgcctgtatt ggggggccgc ccaatgcttg

961 cttggatcag ctgcagaact ggttcactat agttgcggag agtctgcagc aagttcggca

1021 gcagcttaaa aagttggagg aattggaaca gaaatacacc tacgaacatg accctatcac

1081 aaaaaacaaa caagtgttat gggaccgcac cttcagtctt ttccagcagc tcattcagag

1141 ctcgtttgtg gtggaaagac agccctgcat gccaacgcac cctcagaggc cgctggtctt

1201 gaagacaggg gtccagttca ctgtgaagtt gagactgttg gtgaaattgc aagagctgaa

1261 ttataatttg aaagtcaaag tcttatttga taaagatgtg aatgagagaa atacagtaaa

1321 aggatttagg aagttcaaca ttttgggcac gcacacaaaa gtgatgaaca tggaggagtc

1381 caccaatggc agtctggcgg ctgaatttcg gcacctgcaa ttgaaagaac agaaaaatgc

1441 tggcaccaga acgaatgagg gtcctctcat cgttactgaa gagcttcact cccttagttt

1501 tgaaacccaa ttgtgccagc ctggtttggt aattgacctc gagacgacct ctctgcccgt

1561. tgtggtgatc tccaacgtca gccagctccc gagcggttgg gcctccatcc tttggtacaa

1621 catgctggtg gcggaaccca ggaatctgtc cttcttcctg actccaccat gtgcacgatg

1681 ggctcagctt tcagaagtgc tgagttggca gttttcttct gtcaccaaaa gaggtctcaa

1741 tgtggaccag ctgaacatgt tgggagagaa gcttcttggt cctaacgcca gccccgatgg

1801 tctcattccg tggacgaggt tttgtaagga aaatataaat gataaaaatt ttcccttctg

1861 gctttggatt gaaagcatcc tagaactcat taaaaaacac ctgctccctc tctggaatga

1921 tgggtgcatc atgggcttca tcagcaagga gcgagagcgt gccctgttga aggaccagca

1981 gccggggacc ttcctgctgc ggttcagtga gagctcccgg gaaggggcca tcacattcac

2041 atgggtggag cggtcccaga acggaggcga acctgacttc catgcggttg aaccctacac

2101 gaagaaagaa ctttctgctg ttactttccc tgacatcatt cgcaattaca aagtcatggc EPI-109 788

2161 tgctgagaat attcctgaga atcccctgaa gtatctgtat ccaaatattg acaaagacca

2221 tgcctttgga aagtattact ccaggccaaa ggaagcacca gagccaatgg aacttgatgg

2281 ccctaaagga actggatata tcaagactga gttgatttct gtgtctgaag tgtaagtgaa

2341 cacagaagag tgacatgttt acaaacctca agccagcctt gctcctggct ggggcctgtt

2401 gaagatgctt gtattttact tttccattgt aattgctatc gccatcacag ctgaacttgt

2461 tgagatcccc gtgttactgc ctatcagcat tttactactt taaaaaaaaa aaaaaaagcc

2521 aaaaaccaaa tttgtattta aggtatataa attttcccaa aactgatacc ctttgaaaaa

2581 gtataaataa aatgagcaaa agttgaa

(2) INFORMATION FOR SEQ ID NO:2621: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 61 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2621

1 ttactaagat gattattgtt ttatagcaat tgaaagaaca gaaaaatgct ggcaccagaa 61 cgaatgaggt gagagtggtt tatgttgtga atgggcc

(2) INFORMATION FOR SEQ ID NO: 2622: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 181 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2622

1 acgacctctc tgcccgttgt ggtgatctcc aacgtcagcc agctcccgag cggttgggcc 61 tccatccttt ggtacaacat gctggtggtg gcggaaccca gggtatggaa aacacatttg 121 ctttggtccc agggtttaag cagagacccc acgctctcgc tgctgcatct cgctgctgca 181 tctctgaaat agccccaat

(2) INFORMATION FOR SEQ ID NO:2623: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 61 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2623

1 ggtctcaatg tggaccagct gaacatgttg ggagagaagc ttcttggtat atgcatatta 61 acttgttatg tttataaaaa ttgaaattca taaaaatatc

(2) INFORMATION FOR SEQ ID NO: 2624: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 121 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2624

1 ctgatcagta gaaaacatgt ttacatcttt gtttgtagtg tatagagcat gaaatcaaga 61 gcctggaaga tttacaagat gaatatgact tcaaatgcaa aaccttgcag aacagaggta 121 agggttcaca actgaagtgg tgcccgttgg

(2) INFORMATION FOR SEQ ID NO: 2625: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 6g66 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2625

1 attaaacctc tcgccgagcc cctccgcaga ctctgcgccg gaaagtttca tttgctgtat

61 gccatcctcg agagctgtct aggttaacgt tcgcactctg tgtatataac ctcgacagtc

121 ttggcaccta acgtgctgtg cgtagctgct cctttggttg aatccccagg cccttgttgg

181 ggcacaaggt ggcaggatgt ctcagtggta cgaacttcag cagcttgact caaaattcct

241 ggagcaggtt caccagcttt atgatgacag ttttcccatg gaaatcagac agtacctggc

301 acagtggtta gaaaagcaag actgggagca cgctgccaat gatgtttcat ttgccaccat

361 ccgttttcat gacctcctgt cacagctgga tgatcaatat agtcgctttt ctttggagaa

421 taacttcttg ctacagcata acataaggaa aagcaagcgt aatcttcagg ataattttca

481 ggaagaccca atccagatgt ctatgatcat ttacagctgt ctgaaggaag aaaggaaaat

541 tctggaaaac gcccagagat ttaatcaggc tcagtcgggg aatattcaga gcacagtgat

601 gttagacaaa cagaaagagc ttgacagtaa agtcagaaat gtgaaggaca aggttatgtg

661 tatagagcat gaaatcaaga gcctggaaga tttacaagat gaatatgact tcaaatgcaa EPI-109 789

721 aaccttgcag aacagagaac acgagaccaa tggtgtggca aagagtgatc agaaacaaga 781 acagctgtta ctcaagaaga tgtatttaat gcttgacaat aagagaaagg aagtagttca 841 caaaataata gagttgctga atgtcactga acttacccag aatgccctga ttaatgatga 901 actagtggag tggaagcgga gacagcagag cgcctgtatt ggggggccgc ccaatgcttg 961 cttggatcag ctgcagaact ggttcactat agttgcggag agtctgcagc aagttcggca 1021 gcagcttaaa aagttggagg aattggaaca gaaatacacc tacgaacatg accctatcac 1081 aaaaaacaaa caagtgttat gggaccgcac cttcagtctt ttccagcagc tcattcagag 1141 ctcgtttgtg gtggaaagac agccctgcat gccaacgcac cctcagaggc cgctggtctt 1201 gaagacaggg gtccagttca ctgtgaagtt gagactgttg gtgaaattgc aagagctgaa 1261 ttataatttg aaagtcaaag tcttatttga taaagatgtg aatgagagaa atacagtaaa 1321 aggatttagg aagttcaaca ttttgggcac gcacacaaaa gtgatgaaca tggaggagtc 1381 caccaatggc agtctggcgg ctgaatttcg gcacctgcaa ttgaaagaac agaaaaatgc 1441 tggcaccaga acgaatgagg gtcctctcat cgttactgaa gagcttcact cccttagttt 1501 tgaaacccaa ttgtgccagc ctggtttggt aattgacctc gagacgacct ctctgcccgt 1561 tgtggtgatc tccaacgtca gccagctccc gagcggttgg gcctccatcc tttggtacaa 1621 catgctggtg gcggaaccca ggaatctgtc cttcttcctg actccaccat gtgcacgatg 1681 ggctcagctt tcagaagtgc tgagttggca gttttcttct gtcaccaaaa gaggtctcaa 1741 tgtggaccag ctgaacatgt tgggagagaa gcttcttggt cctaacgcca gccccgatgg 1801 tctcattccg tggacgaggt tttgtaagga aaatataaat gataaaaatt ttcccttctg 1861 gctttggatt gaaagcatcc tagaactcat taaaaaacac ctgctccctc tctggaatga 1921 tgggtgcatc atgggcttca tcagcaagga gcgagagcgt gccctgttga aggaccagca 1981 gccggggacc ttcctgctgc ggttcagtga gagctcccgg gaaggggcca tcacattcac 2041 atgggtggag cggtcccaga acggaggcga acctgacttc catgcggttg aaccctacac 2101 gaagaaagaa ctttctgctg ttactttccc tgacatcatt cgcaattaca aagtcatggc 2161 tgctgagaat attcctgaga atcccctgaa gtatctgtat ccaaatattg acaaagacca 2221 tgcctttgga aagtattact ccaggccaaa ggaagcacca gagccaatgg aacttgatgg 2281 ccctaaagga actggatata tcaagactga gttgatttct gtgtctgaag ttcacccttc 2341 tagacttcag accacagaca acctgctccc catgtctcct gaggagtttg acgaggtgtc 2401 tcggatagtg ggctctgtag aattcgacag tatgatgaac acagtataga gcatgaattt 2461 ttttcatctt ctctggcgac agttttcctt ctcatctgtg attccctcct gctactctgt 2521 tccttcacat cctgtgtttc tagggaaatg aaagaaaggc cagcaaattc gctgcaacct 2581 gttgatagca agtgaatttt tctctaactc agaaacatca gttactctga agggcatcat 2641 gcatcttact gaaggtaaaa ttgaaaggca ttctctgaag agtgggtttc acaagtgaaa 2701 aacatccaga tacacccaaa gtatcaggac gagaatgagg gtcctttggg aaaggagaag 2761 ttaagcaaca tctagcaaat gttatgcata aagtcagtgc ccaactgtta taggttgttg 2821 gataaatcag tggttattta gggaactgct tgacgtagga acggtaaatt tctgtgggag 2881 aattcttaca tgttttcttt gctttaagtg taactggcag ttttccattg gtttacctgt 2941 gaaatagttc aaagccaagt ttatatacaa ttatatcagt cctctttcaa aggtagccat 3001 catggatctg gtagggggaa aatgtgtatt ttattacatc tttcacattg gctatttaaa 3061 gacaaagaca aattctgttt cttgagaaga gaatattagc tttactgttt gttatggctt 3121 aatgacacta gctaatatca atagaaggat gtacatttcc aaattcacaa gttgtgtttg 3181 atatccaaag ctgaatacat tctgctttca tcttggtcac atacaattat ttttacagtt 3241 ctcccaaggg agttaggcta ttcacaacca ctcattcaaa agttgaaatt aaccatagat 3301 gtagataaac tcagaaattt aattcatgtt tcttaaatgg gctactttgt cctttttgtt 3361 attagggtgg tatttagtct attagccaca aaattgggaa aggagtagaa aaagcagtaa 3421 ctgacaactt gaataataca ccagagataa tatgagaatc agatcatttc aaaactcatt 3481 tcctatgtaa ctgcattgag aactgcatat gtttcgctga tatatgtgtt tttcacattt 3541 gcgaatggtt ccattctctc tcctgtactt tttccagaca cttttttgag tggatgatgt 3601 ttcgtgaagt atactgtatt tttacctttt tccttcctta tcactgacac aaaaagtaga 3661 ttaagagatg ggtttgacaa ggttcttccc ttttacatac tgctgtctat gtggctgtat 3721 cttgtttttc cactactgct accacaacta tattatcatg caaatgctgt attcttcttt 3781 ggtggagata aagatttctt gagttttgtt ttaaaattaa agctaaagta tctgtattgc 3841 attaaatata atatcgacac agtgctttcc gtggcactgc atacaatctg aggcctcctc 3901 tctcagtttt tatatagatg gcgagaacct aagtttcagt tgattttaca attgaaatga 3961 ctaaaaaaca aagaagacaa cattaaaaac aatattgttt eta

1 attaaacctc tcgccgagcc cctccgcaga ctctgcgccg gaaagtttca tttgctgtat 61 gccatcctcg agagctgtct aggttaacgt tcgcactctg tgtatataac ctcgacagtc 121 ttggcaccta acgtgctgtg cgtagctgct cctttggttg aatccccagg cccttgttgg 181 ggcacaaggt ggcaggatgt ctcagtggta cgaacttcag cagcttgact caaaattcct 241 ggagcaggtt caccagcttt atgatgacag ttttcccatg gaaatcagac agtacctggc 301 acagtggtta gaaaagcaag actgggagca cgctgccaat gatgtttcat ttgccaccat 361 ccgttttcat gacctcctgt cacagctgga tgatcaatat agtcgctttt ctttggagaa 421 taacttcttg ctacagcata acataaggaa aagcaagcgt aatcttcagg ataattttca 481 ggaagaccca atccagatgt ctatgatcat ttacagctgt ctgaaggaag aaaggaaaat 541 tctggaaaac gcccagagat ttaatcaggc tcagtcgggg aatattcaga gcacagtgat 601 gttagacaaa cagaaagagc ttgacagtaa agtcagaaat gtgaaggaca aggttatgtg 661 tatagagcat gaaatcaaga gcctggaaga tttacaagat gaatatgact tcaaatgcaa 721 aaccttgcag aacagagaac acgagaccaa tggtgtggca aagagtgatc agaaacaaga EPI-109 790

781 acagctgtta ctcaagaaga tgtatttaat gcttgacaat aagagaaagg aagtagttca 841 caaaataata gagttgctga atgtcactga acttacccag aatgccctga ttaatgatga 901 actagtggag tggaagcgga gacagcagag cgcctgtatt ggggggccgc ccaatgcttg 961 cttggatcag ctgcagaact ggttcactat agttgcggag agtctgcagc aagttcggca 1021 gcagcttaaa aagttggagg aattggaaca gaaatacacc tacgaacatg accctatcac 1081 aaaaaacaaa caagtgttat gggaccgcac cttcagtctt ttccagcagc tcattcagag 1141 ctcgtttgtg gtggaaagac agccctgcat gccaacgcac cctcagaggc cgctggtctt 1201 gaagacaggg gtccagttca ctgtgaagtt gagactgttg gtgaaattgc aagagctgaa 1261 ttataatttg aaagtcaaag tcttatttga taaagatgtg aatgagagaa atacagtaaa 1321 aggatttagg aagttcaaca ttttgggcac gcacacaaaa gtgatgaaca tggaggagtc 1381 caccaatggc agtctggcgg ctgaatttcg gcacctgcaa ttgaaagaac agaaaaatgc 1441 tggcaccaga acgaatgagg gtcctctcat cgttactgaa gagcttcact cccttagttt 1501 tgaaacccaa ttgtgccagc ctggtttggt aattgacctc gagacgacct ctctgcccgt 1561 tgtggtgatc tccaacgtca gccagctccc gagcggttgg gcctccatcc tttggtacaa 1621 catgctggtg gcggaaccca ggaatctgtc cttcttcctg actccaccat gtgcacgatg 1681 ggctcagctt tcagaagtgc tgagttggca gttttcttct gtcaccaaaa gaggtctcaa 1741 tgtggaccag ctgaacatgt tgggagagaa gcttcttggt cctaacgcca gccccgatgg 1801 tctcattccg tggacgaggt tttgtaagga aaatataaat gataaaaatt ttcccttctg 1861 gctttggatt gaaagcatcc tagaactcat taaaaaacac ctgctccctc tctggaatga 1921 tgggtgcatc atgggcttca tcagcaagga gcgagagcgt gccctgttga aggaccagca 1981 gccggggacc ttcctgctgc ggttcagtga gagctcccgg gaaggggcca tcacattcac 2041 atgggtggag cggtcccaga acggaggcga acctgacttc catgcggttg aaccctacac 2101 gaagaaagaa ctttctgctg ttactttccc tgacatcatt cgcaattaca aagtcatggc 2161 tgctgagaat attcctgaga atcccctgaa gtatctgtat ccaaatattg acaaagacca 2221 tgcctttgga aagtattact ccaggccaaa ggaagcacca gagccaatgg aacttgatgg 2281 ccctaaagga actggatata tcaagactga gttgatttct gtgtctgaag tgtaagtgaa 2341 cacagaagag tgacatgttt acaaacctca agccagcctt gctcctggct ggggcctgtt 2401 gaagatgctt gtattttact tttccattgt aattgctatc gccatcacag ctgaacttgt 2461 tgagatcccc gtgttactgc ctatcagcat tttactactt taaaaaaaaa aaaaaaagcc 2521 aaaaaccaaa tttgtattta aggtatataa attttcccaa aactgatacc ctttgaaaaa 2581 gtataaataa aatgagcaaa agttgaa

1 ttactaagat gattattgtt ttatagcaat tgaaagaaca gaaaaatgct ggcaccagaa 61 cgaatgaggt gagagtggtt tatgttgtga atgggcc

1 acgacctctc tgcccgttgt ggtgatctcc aacgtcagcc agctcccgag cggttgggcc 61 tccatccttt ggtacaacat gctggtggtg gcggaaccca gggtatggaa aacacatttg 121 ctttggtccc agggtttaag cagagacccc acgctctcgc tgctgcatct cgctgctgca 181 tctctgaaat agccccaat

1 ggtctcaatg tggaccagct gaacatgttg ggagagaagc ttcttggtat atgcatatta 61 acttgttatg tttataaaaa ttgaaattca taaaaatatc

1 ctgatcagta gaaaacatgt ttacatcttt gtttgtagtg tatagagcat gaaatcaaga 61 gcctggaaga tttacaagat gaatatgact tcaaatgcaa aaccttgcag aacagaggta 121 agggttcaca actgaagtgg tgcccgttgg

(2) INFORMATION FOR SEQ ID NO: 2626: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18601 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2626

1 tcaagatcag cctgggca.ac atggcgaaac cccgtctcta caataaatac aaaaaaatta

61 tcctggcgga gttatgcacg ttgtagtccc aactacctgg gaggctgagg cgggagaatc

121 acctgagcct gggaggtcga ggctgcagcg agccgagatc ggccgctgca ttccagcctg

181 ggtgacagag cgagaccatg tctcaaaaaa taaaaattaa aaaaaaattg ttttcattac

241 ctcagccctc ctcttcctat cccaaggcgt cgaaattccg gtcccacccc ttcccatgga

301 gcccttggcg tctccaggct cctcaagcta gtttcggttc cgggctcacg cgcgggttct

361 cgaaaatcag ctgtttcagt cttgggctag tccactaatt ggactcctcc cctcgtagaa

421 agtgcctact tgaacttctc caccaatcgc tgaagctgca ggtgtggttt cggctcagct

481. tgtcccgccc tggcggaggg gcggagttgc ggcggcgcca gtgagctcgc agtctgggaa

541 gggcttgact gaatggcagc cagtgtcggg gtggcggctg ggaatggggg ccgctccgga

601 cttccgctgc caactacaag ggggcgggtc cgaggggggt tagccgaagt tgtaggcggg

661 gcgcgaggtt ctagtacccg agctcatact agggacggga agtcgcgacc agagccattg

721 gagggcgcgg ggactgcaac cctaatcagg tacgggccct gagagggtgt gctggggtag

781 gggtgggggt gagagtgaga gttcctccga gggaagggcg actggcccag gggttacccc

841 ctggagaggg tagcttcctt ccccagattg aaataggagc tgtcgcctgc tcggtcctcg

901 atcttcttct gtccagccta tctccctaac cctaatgccc ctctcccaaa actgccctgc

961 agcttccgag acccggaatc tggcattgtt atgttggttc ggtatctgac gtttttccct

1021 ctgctctgca ttatttttta tcttcaccaa aaaacgatgt tcaaagatag ataaatctaa EPI-109 791

1081 aaacaaagat agataaatct attacccttg tttcgtaaaa agtataagct actgaaagat 1141 gaaacgattg cctaaggtca cacacaaaat tcagttcatt tcagaaaagc ttcttgagtg 1201 caaaatatgt gcctaagaat gagagataat gagaaaaaat tgtttcagcc ccttaacctc 1261 agtgtttgca atccatttgg ggagaccagg ttttttgttt ttgttttcat atttgaatct 1321 ttgctgactt gctcctttaa tatcagacac ttaaatcctc agatgggact catcatattt 1381 tttttgagat ggaatcttca ctatgttgct caagcttggt ctgcaactcc tggctcaagc 1441 catcctctcg tcttgttggg cctctcgtct tgtgggcctg cacaaagtgc tgggattaca 1501 ggcatgagcc attcatgccc tgggcgcacc ttggattgcg atgtgtgtgt gttgtgaagc 1561 tttttttttt ggtatcataa aagcaataca gatacatagt tttaaaaatc aagcagctac 1621 taaaagagtt aaaatgaaaa tagcccctcc caatccctcc cttgttcctg ctggaggtag 1681 aaaggcagct gatgttattc atgttagtag aagactctcc caccccaagc atttctcttt 1741 attttgtaat aaaatcatgt gaccttttta gaccacaaat atgcatgaat tctgttctgt 1801 taggctcagg ctgcaacaag ataagtttca gtttcctaaa tagacaccag ctggcagtga 1861 gcagggaaca gtggggagaa agatgcatgg gacagcctgc ttggtgacag gcaaaaaccg 1921 gtttgttgtt cttttagaga cagagtcttg ctttgtcacc caggctggag tgtagtgatg 1981 tgatctctgc ttactgcaac cctgcctctg ggtacaagcc attctcctgc ctcagcctct 2041 tgagtagctg ggattacagg caacaatttt aagtgaagtg aagtttcagg atctcgagca 2101 aagttgtata acctataatc atattcaaga ttcacaggtc ataaacgtgt catattcttg 2161 ggattgagcg acccattgca cagcat.ttag atgtgcttct agaatggagc tcctccttcc 2221 tatatggagg gcagtttata tggtgtactt acctgaccac caaaaagatt tggctctaaa 2281 aaagcttcag gtggccgggc atggtggttc acccctgtaa tccagcactt tgggaggcag 2341 gtgggcagat cacctgaggt cagaagttca gacagctgga catatggtga aacctcatct 2401 ctactaaaaa tacaaaaatt agactgggca tggtagtggg cgcctgtaat cccagctagt 2461 cgggaggctg aggcaggaga atcccttcaa ctcggacggc agagtttgca gtgaggccga 2521 gatcgtgtca ctgcagtcca gcctgggtga cagagcaaga ctccatctca aaaaaagtaa 2581 aaaaaaaaaa aagaaaaaaa aaagcttcag agccagcagg gatcatgctg taataaatac 2641 ttaacatcaa cactgatctt taaatgcttt agcacaatca aatataaata acaaacacac 2701 acataaatgc aaaataaatg aattagggag atagatgaaa taagattgtg gaaatagtaa 2761 tgtttgttaa agctggatgg tgatccttgt actattcact ctactctagt gtgtatttga 2821 aaattaccat taggctggtt atggtggctc atgcctgtta atcccggcat tttggaaggc 2881 tgaggcaggc ggattacttg agctcaggag tttagagtct gcctgggcaa catggcaaaa 2941 tcccatctct acaaaaaatt agctggcatg atggcacact cctgtagtcc cagctccttg 3001 aggggctgag gcagagaatg gcttgaacct gagaggctaa agctgcagtg agccaagatc 3061 atgccactgc actccagcc^'t gggtgaccaa gtgagaccct gtctcaaaaa aaaaaaaaaa 3121 aaaaagaaaa gaaaattccc attaaagcac aaaggcccac ttattgaagc tattaaaata 3181 caggttgggg ccggctgggc atcgcgtcac gcctgtaatc ccagcacttt ggaaggccga 3241 ggtaggcgag tcacgagttc aggagatcga gaccatcctg gctaacacgg tgaaacccca 3301 tctctactaa aaatacaaaa aaaaaaatca gccgggcatg gtggcgggag cctatagtcc 3361 cagctactcg ggaggctgag gcaggagaat ggcatgagcc cgggaggcgg agcttgcagt 3421 gagccaaaat cacaccactg cactccagcc tgggcaacag atcgagactc catctgaaga 3481 aaaaaaaaat acaggttggg accacagtgg ctcatgcctg taatcctagt actttgggag 3541 tccgaagtag gtggatcacc tgaggtcagg actttgagac cagcctggcc aacatggcaa 3601 aaccccatct ctactaaaaa atatacaaaa attagctggg cgtggtggtg ggtgcctgta 3661 atcccagcta ctcaggaggc tgaggcagaa gaatcacaac aaccaggggg atggtggttg 3721 caatgagcca agatcatctc cacttcactc cggcccaggc aaaagagtga gagtcatctt 3781 aaaaaaaaaa aaaaaaaaaa aaaaaaaata cagattaggc attcctaatc tgaaaaattt 3841 ggctccaaaa tgctccagtc gagcatttcc tttgagtgtc atgtgggtgc tcaaaaagtt 3901 agatttttgg accattttca gatttcagag ttttggatta gggatgctcg actggtaagt

3961 aatcgagata ttccaaaaat ctggacaaat ctgaaatcca aaatgcttgg aatagcagat

4021 actcaactgg tagcactccc tggaagaata tgcaccaaac tgatagcagt ggttaccttc 4081 tggtgaggag gggaaagaac caagattagc agtaggatca acatatattt taatgttttc 4141 tgtattttta ttacttgtat aatttaaaca ttttaaatta gtaataatga acaatcatga 4201 aactatggat gatttagtcc agcaaaatat ccaattggga accctcatcc ttctgcagag 4261 cccaaatggc gcagtgggaa atgctgcaga atcttgacag cccctttcag gatcagctgc 4321 accagcttta ctcgcacagc ctcctgcctg tggacattcg acagtacttg gctgtctgga 4381 ttgaagacca gaactggtga ggccttcagg aagttggggg aatgaaaaag gtggccttcc 4441 acttctgggc ccccgggatc ctggaatcat taatggcagg aaggggttgg aaagcctcag 4501 gactacagta acactgcaga gacactaata cttcttattc ctggtcccag gcaggaagct 4561 gcacttggga gtgatgattc caaggctacc atgctattct tccacttctt ggatcagctg 4621 aactatgagt gtggccgttg cagccaggac ccagagtcct tgttgctgca gcacaatttg 4681 cggaaattct gccgggacat tcaggtactt ggaacggttg ggagtgatgg ggtagcactg 4741 ggagcagagc atagaggagt aaggtttgga gaatagaata gtacctggag gtggcaaggg 4801 agacgggaac aaatgtgggg aaaggaggac agagtctgga cttggggaat cactagcaga 4861 gagaagggtt gcatatacgt gacactgttg ggaggatgct atggtgaaaa gacaaagggc 4921 taagaacccc gaaggaggag gaaatactgt ggacattggt ggggagggtc tagggcaata 4981 ggtcattgag agtggttgaa ttggatcaat cctttctgtt tacctttctg ttagcccttt 5041 tcccaggatc ctacccagtt ggctgagatg atctttaacc tccttctgga agaaaaaaga 5101 attttgatcc aggctcagag ggcccaattg gtgaggacaa ttcagtggta atgttggaaa EPI-109 792

5161 ctcctgaagt agagaggaac catggaaagg actcagggag ttgtctcaga acaggatccc

5221 cccgacatcc tgtggtataa tttcaggcct gaacttaagg catgaaaggc cagagttaaa

5281 acgtgctcag agcctctttt ttcaggaaca aggagagcca gttctcgaaa cacctgtgga

5341 gagccagcaa catgagattg aatcccggat cctggattta agggctatga tggaggttag

5401 tagatgtggt aggagttagg gttgacagtg ttcagcctaa cacctccctg agaagcagcc

5461 tcatcggggt cctctcccct ctgcagaagc tggtaaaatc catcagccaa ctgaaagacc

5521 agcaggatgt cttctgcttc cgatataaga tccaggccaa aggtaggaag cacattgagg

5581 ggctggagaa agataagtgc ctgctgagaa gccggagctg gaagtgaaca ggagaaagct

5641 ccgatgagca gtagtcactg tcagacacac cccactgact acagtcctgc tgccgtgcaa

5701 agctggaatc gtgctttgtg gaggctgagc tggaggtgac agctgagaga cagtaaattg

5761 ttgaggaaat gcatggaaaa ctaacagtgt tttatttgag ggggtgtctg gtccaagatg

5821 accacttcag aatttgcctg gagggtccca caggtgcctg tgctttgctt ggtttccctt

5881 tcttcctccg ccacaaaatt cctccttcct gactctgact gagaccccag tcaggaagga

5941 gaggaaagaa cccctggact gactcctgtt cccaccatcc agggaagaca ccctctctgg

6001 acccccatca gaccaaagag cagaagattc tgcaggaaac tctcaatgaa ctggacaaaa

6061 ggagaaaggt gggaggcag^'c agaacagaac atgtgggcaa caaggacctg aaaaaatgag

6121 ggatgttggg aaccctggta atctagcgct ggcttctttc tttcttcatc cccagttggg

6181 tggtggaggg tgaaagggag agatgctcaa cactcacatt atctctttcc caggaggtgc

6241 tggatgcctc caaagcactg ctaggccgat taactaccct aatcgagcta ctgctgccaa

6301 agttggagga gtggaaggcc cagcagcaaa aagcctgcat cagagctccc attgaccacg

6361 ggttggaaca gctggagaca tggtgagagg taccacccca accctcgtcc tcgccatgcg

6421 ctgtgatttg taagttgcag tgccctgcat atagcaagag atactgttct ctatttgtct

6481 ctgctcccca gaatagagcc ctgctccctg cctgactgca gctctattct gcctcctcag

6541 cctcaccacg cagggaagcc cagaagtccc agtctccttc agggaaagga atgaattaac

6601 ccacaatctg gttttgcttc ttttttttaa tcacccagaa atatatatat atgtattttt

6661 tttttactgc aacgaataca atgacaagaa aggaagggaa ggaaggaagg aagagaaaat

6721 tacctattac ctagcttatt aaacaaaaat ggaatcatat tgtccatact attttgaaat

6781 ccatggggtt ttttttaagc ttaacagtat tttatatata tatatatata tatatatata

6841 tatatatata tatatatata tatatttttt tttttttttt tttttttttt ttttgagacg

6901 gagtctctct ctgttccctg gctggcggag cggagtcggc acgatctcag ctcactgcaa

6961 cttccaactc ccacggttca agccaattct cctgtctcag cctcccgagc ctgggattac

7021 caggcacaca ccagcctggc tagttttttt gattttttag tagagacgat gtttctccat

7081 gttggccagg ctggtctcaa actcctgact tcaggtgatc cacccaactt gggctcccaa

7141 agtgctggga ttacaggcgt gacgaccatg cccggccaac agtatattat atttatccat

7201 gttatttctt atgtccacac aacagtcccc tatatggtgg taacataatt taattaatga

7261 actcctattt tcagctattt aggttatttt caatttcttg ttaccttttg ccaggaaacg

7321 tatattttat ggtaattata ttgtgttgta gaaaaatcac tagtctagtc caacttgctt

7381 gaaaaatagc tactttttaa ctattttctc atttaaaaat ttattataat ttagtctttt

7441 agaaatatac caggccaggc atggcgtctc atgcctgtta tcctagtact ttggaaggct

7501 gaggacggag gatcacttca gtcttggggt ttgagaccag cccgggaaac ataacaagac

7561 cccatctcta caaaaaaaaa aaattgtttt taattaggca tgtccgacac agtggctcac

7621 acatgtggcc agcactgtgg gaaggccaag gtgggtggat cacttgaggg tcaggagttc

7681 aagaccagcc tggccaatgt ggtgaaaccc catctctact aaaaatacaa aaatttgcca

7741 ggtgtggtgg cgcatgcctg tattcccagc tactcaggag gctaaggcag gaaatcactt

7801 gaactcggag gcagaggttg cagtgagctg tgacaatgcc actgtactcc agcctgggtg

7861 acagagcgag ctccgtctca aaaaaaaaaa aaaaagatta ggcatggtgg cacacgcctg

7921 tagaccctag ctactcagga ggctgaggtg ggaggattgc ttgagcccag gtgttggagg

7981 ctgcagtgag ccatgattat accactgtag tccagcctgg acaacagaac gagaccctgt

8041 ctctaaaagt atatatgtac acataccata atacccagct actgaggagg ctgaggcaga

8101 aagagtgctt gagtccagga gtttgatgtc agcctgagca atatagcaag accctcacct

8161 cttaaaaaaa tttaaagtag attaaaaaaa taccacaatt gctcaggtag attaaaaaaa

8221 taccacaatt gctcaggtag attattgaaa aacaggcata tagtacttat ggtacaggac

8281 cagcatgcat gcatgcatgc attgattgat tgattgattg attgattgag acagggtctc

8341 tctctgtctc ccaggctgga gtgcctggcc ttaagtgatc tgcccacctt tgcttcccaa

8401 agtgctgaga ttacaggtgt gagccaccat gtcagctggc gaggcttttt aaaagatagt

8461 tccaagtgtt acagctcttt taggatttgt ctagcaggct ttcaggtttt tgccagaaac

8521 cacccccacc cccaccaaaa aaaaaaaaaa aaaaaagata tgtacaagtt cccagatagt

8581 gttcccaact gaatctattt ctcatgtgta gtgtatggtt gttttcctgt caccacattg

8641 ctgattatta ttatttttaa ttatagagac agtaaagtac agtagttaaa aatgtgagtt

8701^' ggggctgggt gcagtggctc acacctgtaa tcccagcact ttgggaggcc aaggtgggcg

8761 gatcacctga ggtcaggagt tcaagaccag cttggccaac atggcaaaac cccgtctcga

8821 ctaaaaatat atatatataa gttagccggg cgtggtggca acattacctg taatcccagc

8881 tactcgggag gccaacaggc aggagaatct cttgaatcca ggaggtggag gttgcagtga

8941 gccagatcac accattgcac tccagcctgg atgacaagag agtgagactg tctaaaaaaa

9001 aaaaacaaag tgtgagttgt acaatgagac tgcctgggat cacatacaag cttcatccct

9061 tactagttgt attgacccta aagcaagtca ctaacctttc tgtgccctcc agttttatca

9121 tctgtaatgt ggggaaaata atagtacctg cctcagaggg ttgttttgag gattaaatgc

9181 attaatatgt ggaaagggct taatataagt tgtacatagc atatgaaaac tgttatgtta EPI-109 793

9241 aatctattag cagttttata tgtgaaaata gctttgattt tcatttcttg gattatgaat 9301 catgttgaat aatcctttat atgcttcctg gattcttttt ttttcttccc cccagtcagt 9361 ttctgactct tctcatattt atagagagat cttggaacct ggatggggga atccaggaaa 9421 ctcatggatt ccttcttcct gaattttatc acccaggttc acagctggag caaagctgtt 9481 gtttcacctg aggcagctgc tgaaggagct gaagggactg agttgcctgg ttagctatca 9541 ggatgaccct ctgaccaaag gggtggacct acgcaacgcc caggtcacag agttgctaca 9601 gcgtctgctc cacaggtcta gaggccaggc aggaaccctg ggggaaagaa ggaacaaggg 9661 aagccattct tacacatact gagctatata ttctctccac acctctctct cctcgagcct 9721 ttgtggtaga aacccagccc tgcatgcccc aaactcccca tcgacccctc atcctcaaga 9781 ctggcagcaa gttcaccgtc cgaacaaggt tggcattcca gaactcattc ccacttcctt 9841 tttccaaccc tgccactgtg tattttctgg ctttacagct actgcccact cttggctttt 9901 tcagtctttc ctgaatctcc ctacctcgtt gataccccat cgtcctcttt ttcaaacacc 9 61 tagcctatac aaaagccgac tccgaccaca tttccctata ccccttgact tccccaggct 10021 gctggtgaga ctccaggaag gcaatgagtc actgactgtg gaagtctcca ttgacaggta 10081 aattggagca ggtgaagggt ggccaggaca cgggctgctg gggtggagga gatactcact 10141 cttcacaaca gggccctagg gctatatcct tcctccttcc aatcctacct cacagaaatt 10201 ataattcatt tcttttgttg aacacttact ttgtgacatg cagcatgtca gctactcatt 10261 taattgtcac accaacccca tgaataaact attaccagtg cactgtacaa acaaagatac 10321 aggcttagag agactgatta catctcttct caaggccaca tagctagtga gctcaagtcg 10381 ggtttgaacc gaggtctgtc tgatcccaaa gacgaaactc ctaacttcca tactcttttg 10441 cccaatgatt ttttttaaat ttatttcttt tcaggaatcc tcctcaatta caagggtagg 10501 tgcttgacaa ggacactgca aacatctgta cagtgtatga cctgcagaac cgggggattt 10561 gggaaatgga caaagggaga tggcgagatc tgaaatggaa gtggaacttc agtttttttt 10621 ttttctgctg agtttttaca ataattccat tccttgtctc catgtatctt cctcctggaa 10681 cagcttccgg aagttcaaca ttctgacttc aaaccagaaa actttgaccc ccgagaaggg 10741 gcagagtcag ggtttgattt gggactttgg ttacctggta agaatagttt gtgacctatg 10801 cttttattac tatttttatt ttttcgagac ggagtctcac tctgtccccc aggctggagt 10861 gcagtggtgc catcttggct cacaggaacc tccgccctcc ccggttcaag caattcttct 10921 gtctcagcct cctgagtacg tagagctata ggcagcacac caccatgccc ggctaatttt 10981 tgtattttta gtagagatag ggtttcacca tattggtcgg gctggtctcg aactcctgac 11041 ctcaggtgat ccgacccgcc tcagcctccc aaagtgctgg gatcacaggc atgagccacc 11101 atagctggcc tgcttttagt ccaaaggaac aggggttggg ggaagttccc agggcttgag 11161 aggtcttgaa gccaaacagg ggttccaggg agactagggt gcccactctg gcattttctc 11221 tccttccctt caattcacag actctggtgg agcaacgttc aggtggttca ggaaagggca 11281 gcaataaggt gagatctgga cagaggactc gaggcagggg gagcttgcca aagagccttc 11341 tgatgactat gtctttgcct gtcccagagg ggccactagg tgtgacagag gaactgcaca 11401 tcatcagctt cacggtcaaa tatacctacc agggtctgaa gcaggagctg aaagtgagtg 11461 aaaatggagg gcaaggagag agaaagcagc tttggaagaa ggcataagaa ggggataaac 11521 agaagcctct tggggagggt tagcactcct ttcctctaac aaatacctgc agctagaaac 11581 atcacatccc tctctgtgac tcctgtcttc tccccacaca cggacaccct ccctgtggtg 11641 attatttcca acatgaacca gctctcaatt gcctgggctt cagttctctg gttcaatttg 11701 ctcagcccaa accttcaggt aggggagtgg ggccgacagg tcccggcgcg agagcagggg 11761 tgtggaagct tggtgtgata ggttgcttct gagccagcct acactgctcc cacccctgca 11821 gaaccagcag ttcttctcca acccccccaa ggccccctgg agcttgctgg gccctgctct 11881 cagttggcag ttctcctcct atgttggccg aggcctcaac tcagaccagc tgagcatgct 11941 gagaaacaag ctgttcggta cagatttcct tttctctcag cctttcccca gccttagtct 12001 tttctgtccc tctgtcctat ctatcccagg acccctggct tccctcacat atctgtggct 12061 atctgtccca cagggcagaa ctgtaggact gaggatccat tattgtcctg ggctgacttc 12121 actaaggtaa ctccctgaat cctgtggagc tgctggatct agccccacat tccaaatact 12181 ggccttccca cgtgccctcc ttccctacac cagaggcaac tcctcagctt ttgctacctt 12241 tccattcctc cagcgagaga gccctcctgg caagttacca ttctggacat ggctggacaa 12301 aattctggag ttggtacatg accacctgaa ggatctctgg aatgatgggt aaggccttgg 12361 tcacccttcc ctcatgggct tgtgcttccg ggcttgagag tggagtctct gcaccctcac 12421 gtggcaagca gggagagaga gcaaagcacg gtgcaggcca cgtctcctca catttgttaa 12481 gaataataag gccgggtgtg gtggctcaca cctgtaatcc cagcactttg ggaggccgag 12541 gcgggcggat catgaggtca ggagatcgag accatcctgg ctaacacggt gaaaccccgt 12601 ctctactcta aaaatacaaa aaattagccg ggcgtggagg cagacaccct gtagtcccag 12661 ctactcagga ggctgaggca ggaaaatggc gtgaacctgg gagatggagc ttgcagtgag 12721 ccgagattgc gtcactgccc tccagccttg gggtgacgta gcaagactcc gtctcaaaaa 12781 aaaaaaaaaa aaacaaccaa taatagccat aaacagtgtt tttgtgaagc actcctacat 12841 tccagagctt gatgggtgct cttcattaat tctctcatct catccttaca accatgctga 12901 gtggtgggtt ttgccagctt catttcatgt gaggaaactg agtttcagag aagttaaaga 12961 acttacccaa gggacacagt tgatattcaa atccaggcct atgtgactcc aagcccatgc 13021 tctttccacc acactgccta ccaacttgtg tagcatttgg cttttaaaag tgctattcat 13081 gaccaggcac gatggctcac gccttgtaat cccagcattt tgggaggccg aggtgggtgg 13141 atcacctgag gtcaggagtt tgagaccagc ctggccaaca tggcgaaacc ccatctctat 13201 taaaaataca aaaattagcc gggtgtggtg gtgggcgcct gtaatcccag ctactcagga 13261 ggctgaggag gagaatcgct tgaatttagg agagaaggtt acagtgagcc aagatcgtgc EPI-109 794

13321 cattgcactc cagcctgggt gacagagcaa gactctgtct caaaacaaaa ccaaaaaaaa 13381 gtgctatttg tggccaggcg tggttgctca tgcctgtaat cctagcattt ttggggaggc 13441 tgaggagtac agatcacttg agcccaggag ttcaaaacta ccctgggcca cgtggtgaaa 13501 ccccaaaccc cgtctctacg aaaaatacaa aagttagcca ggatgggtgg tgtgcacctg 13561 tggtcccagc tactctggag gctgagaggt ggggaagatt gcttgagccc gggaggtcga 13621 ggtggcagtg agctgtgatc atgccactat tctccagcct gggtgacaga atacaccctg 13681 tctccctgtc tcccagaaaa aaaaaaaagt gctgttcatc tgtgtgatct cactgaatct 13741 tcgtacttca aaccctcgga aggtggctat tgtcagcaaa gtgaagtgac ttgtaaaaga 13801 taaaaaaaag ctaagtggca gggcttggtc caaagcctgg attccaaacc tgggctgttt 13861 ctccatacaa ggggagcagg gaggcagggg cctggggggg cagggtgttg ggcggtgtca 13921 cacgtgacac actgtgctcc agacgcatca tgggctttgt gagtcggagc caggagcgcc 13981 ggctgctgaa gaagaccatg tctggcacct ttctactgcg cttcagtgaa tcgtcagaag 14041 ggggcattac ctgctcctgg gtggagcacc aggatgatgg tagctgctct gccctgccat 14101 tcccacagcc tctcctttct gcctggctct cctctggccc ctctgcctgc cttgcttcgc 14161 tggctctgaa ctgaatgctc agtggtttgg gactgggcag ccagagagtc agagagctcc 14221 aaggcccggc ctcttccctc aagcccgcct gttcctgcat tcactctcca gacaaggtgc 14281 tcatctactc tgtgcaaccg tacacgaagg aggtgctgca gtcactcccg ctgactgaaa 14341 tcatccgcca ttaccagttg ctcactgagg agaatatacc tgaaaaccca ctgcgcttcc 14401 tctatccccg aatcccccgg gatgaagctt ttgggtgcta ctaccaggag aaaggtggga 14461 atcgttgaca tacttcattg ctagattgca gagatctacc agacatccat agatcccact 14521 ccttccttta aagcatggga aaactgatat ctagaggaat taagggattc gtccatggga 14581 tactgctggt tactatgggg atgagactgc caggaccatc tgcactaggg gaaaacctca 14641 ggctatatgt ctggcccact gatcttctct gcttcttgta tatgttcctc acagttaatc 14701 tccaggaacg gaggaaatac ctgaaacaca ggctcattgt ggtctctaat agagtgagat 14761 atgaactgtt cattcatcct ccctaatcct tattggctct gcttcagtga atcgtcaaaa 14821 gggggcatta ccttctcctg ggtggagcac caggatgatg gtcagctgct ctgccctgcc 14881 attcccacag cctctccttt ctgccttctc ctaagctgcc cctattccag tctccccagc 14941 cttccctccc tcctagcccc actctagttt tttctggttc tagtctctcc tatctcatat 15001 ttttctgctg ccatccttag gttgtctcca caggggtttc tggataataa tgatcataat 15061 cactggtgtt aaggggtacc tacttgatgc aagcatggag cttttttttt ttccagacag 15121 ggttttgttc tgtcgcccag gctggagtgc agtggtgtga tcctggctca ctgcagcctc 15181 gacctcctga gctcaagcaa tacaggcatg catcaccaaa ctcagctaat tttttttgta 15241 ttttttgtag agatggggtc ttaccatgtt gacgcatcag gctgttctga actcctggac 15301 tcaagcaatc cacccacctt ggcctcccaa aagtcaggga ttacaggcgt gcgaccacac 15361 cccgcatata tatatttttt tttttttttt tttttttttt tttttgagac agggtctctg 15421 ttatccaggc tggagttgca gtggataata tgactacgag ccttgaccta ggggttgaag 15481 caatgctcct gcctcagcca ccaagtgctg agactacagg cacacgccaa tctacactca 15541 atcacactca gctaattttt taaatttttt gtagggatgg ggtatcactg tgtttgccca 15601 ggctggtctt gaactcctgg cctcaagcag tctcctgcct tggcctccca aattgccggg 15661 attgtaggaa tgagccatgg cacttggctg ggggatagaa tttttttttt tttttttttt 15721 tttttttttt ttgagacagt ctcactctca ttgcccgggc tggagtgcag tggtgcaatt 15781 tcagctcact gcaacctctg cctcccaggc tcaagcaatt ctcctgcctc agcctataga 15841 gtagctggga ttacaggcga gcgccaccca tgcctggtta atttttgttt tttttttgag 15901 acagagtctc gccctgttgc ccaggctgga gtgcagtggc acgatctcag ctcactgcaa 15961 cctctgcctc ccaggctcaa gcaattctcc tgcctcagcc tcctgagtac tgggactaca 16021 agcgcgcaca accaccacac ctggtaattt ttgtattttt agtagagaca gggttttacc 16081 atattggcca ggctggtctc aaactcctga cctcatgatc cgacccacct tggcctccca 16141 aagtgcaggg attacaggcg tgagcctctg cacccggcct aacttttgta tttttagtag 16201 aaacagggtt tcaccatgtt ggccaggctg gtcatgagct cctggcctca agtgatctgc 16261 ccgcctcagc ctcccaaagt gcttggatta caggtgtgag ccacctggcc tgagagttta 16321 ttatgcgcca ggcactaggc aaatggtttg catttatttt ctcattttat tgaatctaca 16381 aaatagtcct gtgaagtaaa cactgttact gttttcagct aaggaactgg atttagagta 16441 gtcaagtttt gtacctaagg tacgtggcta atgatacagg tctgttagat tccgtagccc 16501 tgattttaac caccctactg cctctcaaga attactaggt attgttctca tttatagatg 16561 ataaatctga ggctcagaaa agttaggcca cttgcctaag gtcccccagc caggattcaa 16621 actccaggag gcctgattcc aaacccatgc tctttagccc tccgccctac tgccttctta 16681 gactagcttc tgcttattct accattcctg atttcatttg aaccactgag ccctgcccct 16741 ttgtctgtct ttgggtatcc aggcaggtgg atgaactgca acaaccgctg gagcttaagc 16801 cagagccaga gctggagtca ttagagctgg aactagggct ggtgccagag ccagagctca 16861 gcctggactt agagccactg ctgaaggcag ggctggatct ggggccagag ctagagtctg 16921 tgctggagtc cactctggag cctgtgatag agcccacact atgcatggta tcacaaacag 16981 tgccagagcc agaccaagga cctgtatcac agccagtgcc agagccagat ttgccctgtg 17041 atctgagaca tttgaacact gagccaatgg aaagtaagtg atgagatgga gtggcacaca 17101 ttccctttcc tacctcttct ccctctccca ttacagaaaa agctgaactc caagctcctc 17161 attggagaga ggtccatctg tgattccttt ttttaggaat tacacatgcc ttcccccacc 17221 tccctgctct ttcatcccac aagttcccac tcaggctctt cccaggcctt tcctgccatc 17281 ctccctccct tgggctgctg ggttgggaac tcctaactaa gatcggggcc tcacttttct 17341 ctctggatta cctagtcttc agaaactgtg taaagattga agaaatcatg ccgaatggtg EPI-109 795

17401 acccactgtt ggctggccag aacaccgtgg atgaggttta cgtctcccgc cccagccact 17461 tctacactga tggacccttg atgccttctg acttctagga accacatttc ctctgttctt 17521 ttcatatctc tttgcccttc ctactcctca tagcatgata ttgttctcca aggatgggaa 17581 tcaggcatgt gtcccttcca agctgtgtta actgttcaaa ctcaggcctg tgtgactcca 17641 ttggggtgag aggtgaaagc ataacatggg tacagagggg acaacaatga atcagaacag 17701 atgctgagcc ataggtctaa ataggatcct ggaggctgcc tgctgtgctg ggaggtatag 17761 gggtcctggg ggcaggccag ggcagttgac aggtacttgg agggctcagg gcagtggctt 17821 ctttccagta tggaaggatt tcaacatttt aatagttggt taggctaaac tggtgcatac 17881 tggcattggc cttggtgggg agcacagaca caggatagga ctccatttct ttcttccatt 17941 ccttcatgtc taggataact tgctttcttc tttcctttac tcctggctca agccctgaat 18001 ttcttctttt cctgcagggg ttgagagctt tctgccttag cctaccatgt gaaactctac 18061 cctgaagaaa gggatggata ggaagtagac ctctttttct taccagtctc ctcccctact 18121 ctgcccccta agctggctgt acctgttcct cccccataaa atgatcctgc caatctaatg 18181 tgagtgtgaa gtttgcacac tagtttatgc tacctagtct ccactttctc aatgcttagg 18241 agacagatca ctcctggagg ctggggatgg taggattgct ggggattttt ttttttttaa 18301 agagggtctc actctgttgc ccaggctaga gtgcaatggt gcaatcacag ctcactgcag 18361 cctcaacctc ctgggttcaa gcaatcctcc tacctcagcc tcctgggtag ctagcaccat 18421 ggcatcgcca ccatgcccta tttttttttt ttaaagacag ggtcttgcta tattgcccag 18481 gctggtcttg aactgggctc aagtgatcct cacgccttgc ctcccaaagt gctgggatta 18541 taggcatgag ccactgtgct tggccaggat tttttttttt ttttttttga gatggagttt 18601 ctctcttgtt gtccaggctg gagtgcaatg gtgtgatccg gggaattc

, 2 ) INFORMATION FOR SEQ ID NO: 2627: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2761 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2627

1 cagctggaat tcggggcggc ggcgcagact gggaggggga gccgggggtt ccgacgtcgc

61 agccgaggga acaagcccca accggatcct ggacaggcac cccggcttgg cgctgtctct

121 ccccctcggc tcggagaggc ccttcggcct gagggagcct cgccgcccgt ccccggcaca

181 cgcgcagccc cggcctctcg gcctctgccg gagaaacagg atggcccaat ggaatcagct

241 acagcagctt gacacacggt acctggagca gctccatcag ctctacagtg acagcttccc

301 aatggagctg cggcagtttc tggccccttg gattgagagt caagattggg catatgcggc

361 cagcaaagaa tcacatgcca ctttggtgtt tcataatctc ctgggagaga ttgaccagca

421 gtatagccgc ttcctgcaag agtcgaatgt tctctatcag cacaatctac gaagaatcaa

481 gcagtttctt cagagcaggt atcttgagaa gccaatggag attgcccgga ttgtggcccg

541 gtgcctgtgg gaagaatca.c gccttctaca gactgcagcc actgcggccc agcaaggggg

601 ccaggccaac caccccacag cagccgtggt gacggagaag cagcagatgc tggagcagca

661 ccttcaggat gtccggaaga gagtgcagga tctagaacag aaaatgaaag tggtagagaa

721 tctccaggat gactttgatt tcaactataa aaccctcaag agtcaaggag acatgcaaga

781 tctgaatgga aacaaccagt cagtgaccag gcagaagatg cagcagctgg aacagatgct

841 cactgcgctg gaccagatgc ggagaagcat cgtgagtgag ctggcggggc ttttgtcagc

901 gatggagtac gtgcagaaaa ctctcacgga cgaggagctg gctgactgga agaggcggca

961 acagattgcc tgcattggag gcccgcccaa catctgccta gatcggctag aaaactggat

1021 aacgtcatta gcagaatctc aacttcagac ccgtcaacaa attaagaaac tggaggagtt

1081 gcaccaaaaa gtttcctaca aaggggaccc cattgtacag caccggccga tgctggagga

1141 gaggatcgtg gagctgttca gaaacttaat gaaaagtgcc tttgtggtgg agcggcagcc

1201 ctgcatgccc atgcatcctg accggcccct cgtcatcaag accggcgtcc agttcactac

1261 taaagtcagg ttgctggtca agttccctga gttgaattat cagcttaaaa ttaaagtgtg

1321 cattgacaaa gactctgggg acgttgcagc tctcagagga tcccggaaat ttaacattct

1381 gggcacaaac acaaaagtga tgaacatgga agaatccaac aacggcagcc tctctgcaga

1441 attcaaacac ttgaccctga gggagcagag atgtgggaat gggggccgag ccaattgtga

1501 tgcttccctg attgtgactg aggagctgca cctgatcacc tttgagaccg aggtgtatca

1561 ccaaggtctc aagattgacc tagagaccca ctccttgtca gttgtggtga tctccaacat

1621 ctgtcagatg ccaaatgcct gggcgtccat cctgtggtac aacatgctga ccaacaatcc

1681 caagaatgtg aacttcttca ctaagccgcc aattggaacc tgggaccaag tggccgaggt

1741 gctcagctgg cagttctcgt ccaccaccaa gcgggggctg agcatcgagc agctgacaac

1801 gctggctgag aagctcctag ggcctggtgt gaactactca gggtgtcaga tcacatgggc

1861 taacttctgc aaagaaaaca tggctggcaa gggcttctcc tactgggtct ggctagacaa

1921 tatcatcgac cttgtgaaaa agtatatctt ggccctttgg aatgaagggt acatcatggg

1981 tttcatcagc aaggagcggg agcgggccat cttgagcact aagcccccag gcaccttcct

2041 gctgcgcttc agtgaaagca gcaaagaagg aggcgtcact ttcacttggg tggagaagga

2101 catcagcggt aagacccaga tccagtccgt ggaaccatac acaaagcagc agctgaacaa

2161 catgtcattt gctgaaatca tcatgggcta taagatcatg gatgctacca atatcctgtt

2221 gtctccactt gtctatctct atcctgacat tcccaaggag gaggcattcg ggaagtattg

2281 tcggccagag agccaggagc atcctgaagc tgacccaggt agcgctgccc catacctgaa

2341 gaccaagttt atctgtgtga caccaacgac ctgcagcaat accattgacc tgccgatgtc EPI-109 796

2401 cccccgcgct ttagattcat tgatgcagtt tggaaataat ggtgaaggtg ctgaaccctc

2461 agcaggaggg cagtttgagt ccctcacctt tgacatggag ttgacctcgg agtgcgctac

2521 ctcccccatg tgaggagctg agaacggaag ctgcagaaag atacgactga ggcgcctacc

2581 tgcattctgc cacccctcac acagccaaac cccagatcat ctgaaactac taactttgtg

2641 gttccagatt ttttttaatc tcctacttct gctatctttg agcaatctgg gcacttttaa

2701 aaatagagaa atgagtgaat gtgggtgatc tgcttttatc taaatgcaaa taaggatgtg

2761 ttctctgaga cccatgatca ggggatg

(2) INFORMATION FOR SEQ ID NO: 2628: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 181 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2628

1 cgacagcgac cagatcaagg aggaactgcc ggagcccttt gagcatcttc tgcagagaat 61 cgcccggaga cccaagcctc agcagttctt tggattaatg ggcaaacggg atgctggaca 121 tggccagatc tctcacaaaa gacataaaac agattccttt gttggactaa tgggcaaaag 181 agctttaaat tctgtggctt atgaaaggag tgcaatgca

(2) INFORMATION FOR SEQ ID NO: 2629: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1021 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2629

1 gagagtgcgg agcgaccacg tgcgctcgga ggaaccagag aaactcagca ccccgcggga 61 ctgtccgtcg caaaatccaa catgaaaatc ctcgtggcct tggcagtctt ttttcttgtc 121 tccactcagc tgtttgcaga agaaatagga gccaatgatg atctgaatta ctggtccgac 181 tggtacgaca gcgaccagat caaggaggaa ctgccggagc cctttgagca tcttctgcag 241 agaatcgccc ggagacccaa gcctcagcag ttctttggat taatgggcaa acgggatgct 301 gattcctcaa ttgaaaaaca agtggccctg ttaaaggctc tttatggaca tggccagatc 361 tctcacaaaa gacataaaac agattccttt gttggactaa tgggcaaaag agctttaaat 421 tctgtggctt atgaaaggag tgcaatgcag aattatgaaa gaagacgtta ataaactacc 481 taacattatt tattcagctt catttgtgtc aatgggcaat gacaggtaaa ttaagacatg 541 cactatgagg aataattatt tatttaataa caattgttta gggttgaaaa ttcaaaaagt 601 gtttattttt catattgtgc caatatgtat tgtaaacatg tgttttaatt ccaatatgat 661 gactccctta aaatagaaat aagtggttat ttctcaacaa agcacagtgt taaatgaaat 721 tgtaaaacct gtcaatgata cagtccctaa agaaaaaaaa tcattgcttt gaagcagttg 781 tgtcagctac tgcggaaaag gaaggaaact cctgacagtc ttgtgctttt cctatttgtt 841 ttcatggtga aaatgtactg agattttggt attacactgt atttgtatct ctgaagcatg 901 tttcatgttt tgtgactata tagagatgtt tttaaaagtt tcaatgtgat tctaatgtct 961 tcatttcatt gtatgatgtg ttgtgatagc taacatttta aataaaagaa aaaatatctt 1021 g

(2) INFORMATION FOR SEQ ID NO:2630: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2581 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2630

1 gcgccgcaag gcactgagca ggcgaaagag cgcgctcgga cctccttccc ggcggcagct

61 accgagagtg cggagcgacc agcgtgcgct cggaggaacc agagaaactc agcaccccgc

121 gggactgtcc gtcgcaaaat ccaacatgaa aatcctcgtg gccttggcag tcttttttct

181 tgtctccact cagctgtttg cagaagaaat aggagccaat gatgatctga attactggtc

241 cgactggtac gacagcgacc agatcaagga ggaactgccg gagccctttg agcatcttct

301 gcagagaatc gcccggagac ccaagcctca gcagttcttt ggattaatgg gcaaacggga

361 tgctgattcc tcaattgaaa aacaagtggc cctgttaaag gctctttatg gacatggcca

421 gatctctcac aaaagacata aaacagattc ctttgttgga ctaatgggca aaagagcttt

481 aaattctgtg gcttatgaaa ggagtgcaat gcagaattat gaaagaagac gttaataaac

541 tacctaacat tatttattca gcttcatttg tgtcaatggg caatgacagg taaattaaga

601 catgcactat gaggaataat tatttattta ataacaattg tttggggttg aaaattcaaa

661 aagtgtttat ttttcatatt gtgccaatat gtattgtaaa catgtgtttt aattccaata

721 tgatgactcc cttaaaatag aaataagtgg ttatttctca acaaagcaca gtgttaaatg

781 aaattgtaaa acctgtcaat gatacagtcc ctaaagaaaa aaaatcattg ctttgaagca

841 gttgtgtcag ctactgcgga aaaggaagga aactcctgac agtcttgtgc ttttcctatt

901 tgttttcatg gtgaaaatgt actgagattt tggtattaca ctgtatttgt atctctgaag

961 catgtttcat gttttgtgac tatatagaga tgtttttaaa agtttcaatg tgattctaat EPI-109 797

1021 gtcttcattt cattgtatga tgtgttgtga tagctaacat tttaaataaa agaaaaaata 1081 tcttgaaaaa aaaaaaaaaa aa

(2) INFORMATION FOR SEQ ID NO:2631: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2283 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2631

1 cgacagcgac cagatcaagg aggaactgcc ggagcccttt gagcatcttc tgcagagaat

61 cgcccggaga cccaagcctc agcagttctt tggattaatg ggcaaacggg atgctggaca

121 tggccagatc tctcacaaaa gacataaaac agattccttt gttggactaa tgggcaaaag

181 agctttaaat tctgtggctt atgaaaggag tgcaatgca

1 gagagtgcgg agcgaccacg tgcgctcgga ggaaccagag aaactcagca ccccgcggga

61 ctgtccgtcg caaaatccaa catgaaaatc ctcgtggcct tggcagtctt ttttcttgtc

121 tccactcagc tgtttgcaga agaaatagga gccaatgatg atctgaatta ctggtccgac

181 tggtacgaca gcgaccagat caaggaggaa ctgccggagc cctttgagca tcttctgcag

241 agaatcgccc ggagacccaa gcctcagcag ttctttggat taatgggcaa acgggatgct

301 gattcctcaa ttgaaaaaca agtggccctg ttaaaggctc tttatggaca tggccagatc

361 tctcacaaaa gacataaaac agattccttt gttggactaa tgggcaaaag agctttaaat

421 tctgtggctt atgaaaggag tgcaatgcag aattatgaaa gaagacgtta ataaactacc

481 taacattatt tattcagctt catttgtgtc aatgggcaat gacaggtaaa ttaagacatg

541 cactatgagg aataattatt tatttaataa caattgttta gggttgaaaa ttcaaaaagt

601 gtttattttt catattgtgc caatatgtat tgtaaacatg tgttttaatt ccaatatgat

661 gactccctta aaatagaaat aagtggttat ttctcaacaa agcacagtgt taaatgaaat

721 tgtaaaacct gtcaatgata cagtccctaa agaaaaaaaa tcattgcttt gaagcagttg

781 tgtcagctac tgcggaaaag gaaggaaact cctgacagtc ttgtgctttt cctatttgtt

841 ttcatggtga aaatgtactg agattttggt attacactgt atttgtatct ctgaagcatg

901 tttcatgttt tgtgactata tagagatgtt tttaaaagtt tcaatgtgat tctaatgtct

961 tcatttcatt gtatgatgtg ttgtgatagc taacatttta aataaaagaa aaaatatctt

1021 g

1 gcgccgcaag gcactgagca ggcgaaagag cgcgctcgga cctccttccc ggcggcagct

61 accgagagtg cggagcgacc agcgtgcgct cggaggaacc agagaaactc agcaccccgc

121 gggactgtcc gtcgcaaaat ccaacatgaa aatcctcgtg gccttggcag tcttttttct

181 tgtctccact cagctgtttg cagaagaaat aggagccaat gatgatctga attactggtc

241 cgactggtac gacagcgacc agatcaagga ggaactgccg gagccctttg agcatcttct

301 gcagagaatc gcccggagac ccaagcctca gcagttcttt ggattaatgg gcaaacggga

361 tgctgattcc tcaattgaaa aacaagtggc cctgttaaag gctctttatg gacatggcca

421 gatctctcac aaaagacata aaacagattc ctttgttgga ctaatgggca aaagagcttt

481 aaattctgtg gcttatgaaa ggagtgcaat gcagaattat gaaagaagac gttaataaac

541 tacctaacat tatttattca gcttcatttg tgtcaatggg caatgacagg taaattaaga

601 catgcactat gaggaataat tatttattta ataacaattg tttggggttg aaaattcaaa

661 aagtgtttat ttttcatatt gtgccaatat gtattgtaaa catgtgtttt aattccaata

721 tgatgactcc cttaaaatag aaataagtgg ttatttctca acaaagcaca gtgttaaatg

781 aaattgtaaa acctgtcaat gatacagtcc ctaaagaaaa aaaatcattg ctttgaagca

841 gttgtgtcag ctactgcgga aaaggaagga aactcctgac agtcttgtgc ttttcctatt

901 tgttttcatg gtgaaaatgt actgagattt tggtattaca ctgtatttgt atctctgaag

961 catgtttcat gttttgtgac tatatagaga tgtttttaaa agtttcaatg tgattctaat

1021 gtcttcattt cattgtatga tgtgttgtga tagctaacat tttaaataaa agaaaaaata

1081 tcttgaaaaa aaaaaaaaaa aa

(2) INFORMATION FOR SEQ ID NO: 2632: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1621 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2632

1 gaaaaagcct tccaccctcc tgtctggctt tagaaggacc ctgagcccca ggcgccacga

61 caggactctg ctgcagaggg gggttgtgta cagatagtag ggctttaccg cctagcttcg

121 aaatggataa cgtcctcccg gtggactcag acctctcccc aaacatctcc actaacacct

181 cggaacccaa tcagttcgtg caaccagcct ggcaaattgt cctttgggca gctgcctaca

241 cggtcattgt ggtgacctct gtggtgggca acgtggtagt gatgtggatc atcttagccc

301 acaaaagaat gaggacagtg acgaactatt ttctggtgaa cctggccttc gcggaggcct

361 ccatggctgc attcaataca gtggtgaact tcacctatgc tgtccacaac gaatggtact

421 acggcctgtt ctactgcaag ttccacaact tcttccccat cgccgctgtc ttcgccagta

481 tctactccat gacggctgtg gcctttgata ggtacatggc catcatacat cccctccagc EPI-109 798

541 cccggctgtc agccacagcc accaaagtgg tcatctgtgt catctgggtc ctggctctcc

601 tgctggcctt cccccagggc tactactcaa ccacagagac catgcccagc agagtcgtgt

661 gcatgatcga atggccagag catccgaaca agatttatga gaaagtgtac cacatctgtg

721 tgactgtgct gatctacttc ctccccctgc tggtgattgg ctatgcatac accgtagtgg

781 gaatcacact atgggccagt gagatccccg gggactcctc tgaccgctac cacgagcaag

841 tctctgccaa gcgcaaggtg gtcaaaatga tgattgtcgt ggtgtgcacc ttcgccatct

901 gctggctgcc cttccacatc ttcttcctcc tgccctacat caacccagat ctctacctga

961 agaagtttat ccagcaggtc tacctggcca tcatgtggct ggccatgagc tccaccatgt

1021 acaaccccat catctactgc tgcctcaatg acaggttccg tctgggcttc aagcatgcct

1081 tccggtgctg ccccttcatc agcgccggcg actatgaggg gctggaaatg aaatccaccc

1141 ggtatctcca gacccagggc agtgtgtaca aagtcagccg cctggagacc accatctcca

1201 cagtggtggg ggcccacgag gaggagccag aggacggccc caaggccaca ccctcgtccc

1261 tggacctgac ctccaactgc tcttcacgaa gtgactecaa gaecatgaca gagagcttea

1321 gcttctcctc caatgtgctc tcctaggcca cagggccttt ggcaggtgca geecceactg

1381 cctttgacct gcctcccttc atgcatggaa attcccttca tctggaacca tcagaaacac

1441 cctcacactg ggacttgcaa aaagggtcag tatgggttag ggaaaacatt ccatccttga

1501 gtcaaaaaat ctcaattctt ccctatcttt gccaccctca tgctgtgtga ctcaaaccaa

1561 atcactgaac tttgctgagc ctgtaaaata aaaggtcgga ccagcttttc ccaaaagccc

1621 attcattcca ttctggaagt gactttggct gcatgcgagt gctcatttca ggat

(2) INFORMATION FOR SEQ ID NO: 2633: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2581 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2633

1 aattcagagc caccgcgggc aggcgggcag tgcatccaga agcgtttata ttctgagcgc

61 cagttcagct ttcaaaaaga gtgctgccca taaaaagcct tccaccctcc tgtctgcttt

121 agaaggaccc tgagccccag gcgccagcca caggactctg ctgcagaggg gggttgtgta

181 cagatagtag gctttacgcc tagcttcgaa atggataacg tcctcccggt ggactcagac

241 ctctccccaa acatctccac taacacctcg gaacccaatc agttcgtgca accagcctgg

301 caaattgtcc tttgggcagc tgcctacacg gtcattgtgg tgacctctgt ggtgggcaac

361 gtggtagtga tgtggatcat cttagcccac aaaagaatga ggacagtgac gaactatttt

421 ctggtgaacc tggccttcgc ggaggcctcc atggctgcat tcaatacagt ggtgaacttc

481 acctatgctg tccacaacga atggtactac ggcctgttct actgcaagtt ccacaacttc

541 tttcccatcg ccgctgtct^'t cgccagtatc tactccatga cggctgtggc ctttgatagg

601 tacatggcca tcatacatcc cctccagccc cggctgtcag ccacagccac caaagtggtc

661 atctgtgtca tctgggtcct ggctctcctg ctggccttcc cccagggcta ctactcaacc

721 acagagacca tgcccagcag agtcgtgtgc atgatcgaat ggccagagca tccgaacaag

781 atttatgaga aagtgtacca catctgtgtg actgtgctga tctacttcct ccccctgctg

841 gtgattggct atgcatacac cgtagtggga atcacactat gggccagtga gatccccggg

901 gactcctctg accgctacca cgagcaagtc tctgccaagc gcaaggtggt caaaatgatg

961 attgtcgtgg tgtgcacctt cgccatctgc tggctgccct tccacatctt cttcctcctg

1021 ccctacatca acccagatct ctacctgaag aagtttatcc agcaggtcta cctggccatc

1081 atgtggctgg ccatgagctc caccatgtac aaccccatca tctactgctg cctcaatgac

1141 aggttccgtc tgggcttcaa gcatgccttc cggtgctgcc ccttcatcag cgccggcgac

1201 tatgaggggc tggaaatgaa atccacccgg tatctccaga cccagggcag tgtgtacaaa

1261 gteagccgcc tggagaccae catctccaca gtggtggggg cccacgagga ggagccagag

1321 gacggcccca aggccacace ctcgtccctg gacctgacet ccaactgctc ttcacgaagt

1381 gactccaaga ccatgacaga gagettcagc ttctcctcca atgtgctctc ctaggccaca

1441 gggcctttgg caggtgcagc ccccactgcc tttgacctgc ctcccttcat gcatggaaat

1501 tcccttcatc tggaaccatc agaaacaccc tcacactggg acttgcaaaa agggtcagta

1561 tgggttaggg aaaacattcc atccttgagt caaaaaatct caattcttcc ctatctttgc

1621 caccctcatg ctgtgtgact caaaccaaat cactgaactt tgctgagcct gtaaaataaa

1681 aggtcggacc agcttttcct caagagccca atgcattcca tttctggaag tgactttggc

1741 tgcatgcgag tgctcatttc aggatg

(2) INFORMATION FOR SEQ ID NO:2634: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2581 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2634

1 gaaaaagcct tccaccctcc tgtctggctt tagaaggacc ctgagcccca ggcgccacga

61 caggactctg ctgcagaggg gggttgtgta cagatagtag ggctttaccg cctagcttcg

121 aaatggataa cgtcctcccg gtggactcag acctctcccc aaacatctcc actaacacct

181 cggaacccaa tcagttcgtg caaccagcct ggcaaattgt cctttgggca gctgcctaca EPI-109 799

241 cggtcattgt ggtgacctct gtggtgggca acgtggtagt gatgtggatc atcttagccc

301 acaaaagaat gaggacagtg acgaactatt ttctggtgaa cctggccttc gcggaggcct

361 ccatggctgc attcaataca gtggtgaact tcacctatgc tgtccacaac gaatggtact

421 acggcctgtt ctactgcaag ttccacaact tcttccccat cgccgctgtc ttcgccagta

481 tctactccat gacggctgtg gcctttgata ggtacatggc catcatacat cccctccagc

541 cccggctgtc agccacagcc accaaagtgg tcatctgtgt catctgggtc ctggctctcc

601 tgctggcctt cccccagggc tactactcaa ccacagagac catgcccagc agagtcgtgt

661 gcatgatcga atggccagag catccgaaca agatttatga gaaagtgtac cacatctgtg

721 tgactgtgct gatctacttc ctccccctgc tggtgattgg ctatgcatac accgtagtgg

781 gaatcacact atgggccagt gagatccccg gggactcctc tgaccgctac cacgagcaag

841 tctctgccaa gcgcaaggtg gtcaaaatga tgattgtcgt ggtgtgcacc ttcgccatct

901 gctggctgcc cttccacatc ttcttcctcc tgccctacat caacccagat ctctacctga

961 agaagtttat ccagcaggtc tacctggcca tcatgtggct ggccatgagc tccaccatgt

1021 acaaccccat catctactgc tgcctcaatg acaggtgagg atcccaaccc catgagctct

1081 ccaggggcca caagaccatc tacatacaca gtggccaagc ggcatcctaa atgagtaaac

1141 ccagctgtga gacaagaggg acaagtgggg actgcagcta acttatcatc acacaactca

1201 gcctggctga ttatcaccat ccaggaatgg gagcccggag tagactgatt ttcttttttt

1261 cttttcca

(2) INFORMATION FOR SEQ ID NO: 2635: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2635

1 atgctgagaa aggtagctgc caaaccttga ctgcaataac aataacaaaa attaaaaacc

61 taaaataata agtatatcat actgaccttt cctgtttacc ttgctgtagg taccacatct

121 gtgtgactgt gctgatctac ttcctccccc tgctggtgat tggctatgca tacaccgtag

181 tgggaatcac actatgggcc agtgagatcc ccggggactc ctctgaccgc taccacgagc

241 aagtctctgc caagcgcaag gtgagcaggg gacaggcaga actaacccac cctggcacag

301 acaacaggct gtcgagaagg gatggcacac ttgtgagccc cagaggcagc tagcacaaaa 361 tatccccagg tat

(2) INFORMATION FOR SEQ ID NO:2636: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2636

1 ggatccaatt tttgcccggc ataagtgtat agtaaatttc ccagccttaa agcacttccc

61 gagagatgct ttgagcgctc gcggtaccag tgcgtaaacg ccgctc ccg gctggcgcgg

121 gtgtgcgcca actccaacct gcgcgcaagt ctgccggtgc gcgctccagt cccacagctc

181 cgagtccccg cagtgaaagg agggggcggt gcaccggggt agatgggccc ctgaggactc

241 ccggggttca gttttccgcg gctgccaaga gggccaagtt ggacagtggc agggtcctga

301 agcagatcag caacaaccgc aagtgctcca gccccaggtc ctcagacacg gaggaaaacg

361 acaagaggcg gacacacaac gtcttggaac gtcagaggag gaacgagctg aagcgcagct

421 tttttgccct gcgtgaccag atccctgaat tggaaaacaa cgaaaaggcc cccaaggtag

481 tgatcctcaa aaaagccacc gcctacatcc tgtccattca agcagacgag cacaagctca

541 cctctgaaaa ggacttattg aggaaacgac gagaacagtt gaaacacaaa ctcgaacagc

601 ttcgaaactc tggtgcataa actgacctaa ctcgaggagg agctggaatc tctcgtgaga

661 gtaaggagaa cggttccttc tgacagaact gatgcgctgg aattaaaatg catgctcaaa

721 gcctaacctc acaaccttgg ctggggcttt gggactgtaa gcttagagac tgtcacttcc

781 caggtgaatc agctagccag gtaactgagc tagatatttt gtgggggtgt ttcctaaaca

841 cagcctcagg aaagttgttt tcgggacacc tggaccaggg agtcgtcgcc tctggcttct

901 cggtagctgg agcgcggccc ggagcgcggc gctggcacat cgcccccaca catgaccgtt

961 tcccattgcc acaggcaagc cgcctctgca gagctgtctc agggctctgg gcttcattcc

1021 ctggaagttg attgtcctcc actccagctg tttcccaaat ccttccttcc tcccagcacc

1081 cctcgtgcaa cgacgattcc agctgcggac cgcatctgtg tcagttactt ccaagccacc

1141 tactgccccc tcgcggagtg cgtggggctc ccggctcgca gactcccacg gcaagtagca

1201 agcagcaaaa ggcgtggtag ctgcggcggt ggaatgagac agttgtcaac agctggcgca

1261 cgtgccgccg tgcgcaccgg gactggcgag tacgcagccc aggtactgcc ccttcccagt

1321 gacgtctctg cagggggtta taaaagcctc gtgcgcagct aactcgcgag ctgagcaacc

1381 cgaaccgaga ggtgcccgcg aaactgcagg cggcggcagc ggcagcaaaa gagaaggaaa

1441 aatctccagc tggatacgaa gctccagaat cctggccata ggctcagaac ttttacaggt

1501 cgcgctgcaa tgggccccca cttcgctcct aagtcctcac gcagcacagg gctttgcctt

1561 tccctgcgga ggaaggagaa ataggagttg caggcagcag caggtgcata aatgcggggg

1621 atctcttgct tcctagaact gtgaccggtg gaatttcttt ccctttttca gtttaccgca EPI-109 800

1681 agagagatgc tgtctccaga cttctgaact caaacgtctc ctgaagcttg aaagtggagg 1741 aattcagagc caccgcgggc aggcgggcag tgcatccaga agcgtttata ttctgagcgc 1801 cagttcagct ttcaaaaaga gtgctgccca gaaaaagcct tccaccctcc tgtctggctt 1861 tagaaggacc ctgagcccca ggcgccagcc acaggactct gctgcagagg ggggttgtgt 1921 acagatagta gggctttacc gcctagcttc gaaatggata acgtcctccc ggtggactca 1981 gacctctccc caaacatctc cactaacacc tcggaaccca atcagttcgt gcaaccagcc 2041 tggcaaattg tcctttgggc agctgcctac acggtcattg tggtgacctc tgtggtgggc 2101 aacgtggtag tgatgtσgat catcttagcc cacaaaagaa tgaggacagt gacgaactat 2161 tttctggtga acctggcctt cgcggaggcc tccatggctg cattcaatac agtggtgaac 2221 ttcacctatg ctgtccacaa cgaatggtac tacggcctgt tctactgcaa gttccacaac 2281 ttcttcccca tcgccgctgt cttcgccagt atctactcca tgacggctgt ggcctttgat 2341 aggtgagatt agcctttgtg aaaaggcgag aaagtgctca tagaggacca tggcattgct 2401 gtgaggtttg gaactgggtg gggtatgggt caagtggaag attggccact ctgagggttt 2461 ttttactgat ca

(2) INFORMATION FOR SEQ ID NO:2637: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2637

1 agaatatgga aaaggaattg gaaaataatt gtacaaatca tcaggaatca aagggtttct 61 atgaattttc ttattggcag gaaaaatatg gaatctctga tacagatttt ggtgaccaga 121 tcagaacttt gttctttctt ctctgttcca ggtacatggc catcatacat cccctccagc 181 cccggctgtc agccacagcc accaaagtgg tcatctgtgt catctgggtc ctggctctcc 241 tgctggcctt cccccagggc tactactcaa ccacagagac catgcccagc agagtcgtgt 301 gcatgatcga atggccagag catccgaaca agatttatga gaaagtgtga gtagagatga 361 ctccccatgc caaagaaacg atggtgcagg ctgccttcct ggccccttct tgctctttct 421 ttctttccat attcttttgt tggtacagat ttaatgtgta tctgcaagca tttctcacat 481 ataccctcat atcaggttga tatgtccaca gttgtcaggg gactatagta tcccaaatac 541 tattctgagc attgaaagat aatttttgaa gtgtaagatc tagatcctgt tata

(2) INFORMATION FOR SEQ ID NO: 2638: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: - base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2638

1 gagggggatg tgctggtggt ctcacctgtc tcaccctctt gccaggtggt caaaatgatg

61 attgtcgtgg tgtgcacctt cgccatctgc tggctgccct tccacatctt cttcctcctg

121 ccctacatca acccagatct ctacctgaag aagtttatcc agcaggtcta cctggccatc

181 atgtggctgg ccatgagctc caccatgtac aaccccatca tctactgctg cctcaatgac

241 aggtgaggat cccaacccca tgagctctcc aggggccaca agaccatcta catacacagt

301 ggccaagcgg catctaaatg agtaaaccca gctgtgagac aagagggaca agtggggact

361 gcagctaact t

(2) INFORMATION FOR SEQ ID NO: 2639: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2639

1 ccgtcccaaa ggtcacctct tcatctgctc gctctccagg ttccgtctgg gcttcaagca

61 tgccttccgg tgctgcccct tcatcagcgc cggcgactat gaggggctgg aaatgaaatc

121 cacccggtat ctccagaccc agggcagtgt gtacaaagtc agccgcctgg agaccaccat

181 ctccacagtg gtgggggccc acgaggagga gccagaggac ggccccaagg ccacaccctc

241 gtccctggac ctgacctcca actgctcttc acgaagtgac tccaagacca tgacagagag

301 cttcagcttc tcctccaatg tgctctccta ggccacaggg cctttggcag gtgcagcccc

361 cactgccttt gacctgcctc ccttcatgca tggaaattcc cttcatctgg aaccatcaga

421 aacaccctca cactgggact tgcaaaaagg gtcagtatgg gttagggaaa acattccatc

481 cttgagtcaa aaaatctcaa ttcttcccta tctttgccac cctcatgctg tgtgactcaa

541 accaaatcac tgaactttgc tgagcctgta aaataaaagg tcggaccagc ttttcccaaa

601 agcccattca ttccattctg gaagtgactt tggctgcatg cgagtgctca tttcaggatg

661 aattctgcag cacagctgcg gacccggaag actcattttc ctggagcccc gtgttacttc

721 aataaagtta tctcagatta gcctcctgca gctggaggct cctatcaccc cagcctacgc

781 ttgacagggt gaacaaaaga aggcaccaca taacatctaa atgaaaaatt tagccctgtc

841 ttctaagcat ctgtgaaaag aaacatatgt attccccttt ttggcatctc agtatttcag EPI-109 801

901 tacatttata catcatgaga ttgagaacct cgggcttcca cattatgtcc ccggtgactg 961 tcctgagcag ccgacgcaag cagaatatgt ccactgatac ctgctagttc tcttacagac 1021 caggaattgg gagacttgca ctacatttaa tgtgtagttg accctctttt cctacttgta 1081 aacaagggga ctgaactaga taatctaagt gttccttcga atcttaacat cccgtggttc 1141 aaggattgta tgagtttttt gtttgtttta caaaaaaaaa caaaacgaag aataaaagaa 1201 tagaaaagaa taggagcagt gagtcttgta actaataccc agttcctgga gatgtagcaa 1261 ctgctaaggc catctgtaac tatccatctc agacattctc cgatttatct taaaatcctg 1321 agtacattcc ttctcatgga aggttttggc ttttgacaga gcagaggact tcatgccaag 1381 gcctgcatcc atccagcttt agcaggcaga atttcatagc tgcagaacac tgtcagagaa 1441 gacaaatgtg ggctccctgc tttaaccttt tgggtatttt agggtggggg ccctaacctt 1501 cattcttagt tttacactag catcgtgctc atatgtgcga caagcaagaa ggctgcactt 1561 tgcagctgca cttctgggaa gagggcatct tgcatcttcc cttcagactc tctgaatgtc 1621 tcctccctgc tccatggctt tgccagcttc ctgtctctaa ggggtagaat gactcatcaa 1681 ccctaaagga cagtcagtct tccaagagcc atgaactgaa tgctttatat cctaatttag 1741 atttagagtt tccagaaggt gagcatgcag ttttgttttg tttttttttc tgtctcccaa 1801 atctgtgttt tttccagata tggctggaag cagaagcttc atgtaacatc catgaatgtc 1861 ctcctggtag tttgcataat ggatgcacat gtgccgcatc cataacatta aggggagaat 1921 aatgcatggt ttacagcctt tgccagccct gctggctcta attctaccag ggcatccaca 1981 ggcctggggg aagaagaaac agtataagcc agaaaacctc aagaactaca ttctctaaag 2041 cagcatggaa agttttaaat aaactaagtg aagccagatc attgcagata tataaatgga 2101 agacaaaatt tagaagcaac aaaagttagt gccctaagca ttagtcatac ttccaataga 2161 gaatcttgct gtgtatggat tactcacttt ggaagaatgt aaagagctaa catgattatg 2221 agaagtacct gagaagatgg tgtcaagaag ttggggacac cccatctatg gaagagaagg 2281 ttagagttga gctcaacgag gattaactga gtgcctcctc tggactttgc cctgaactgg 2341 gaacacacag cccctgcagc tcttgaagag cctaccttat tggccatcac taactaactc 2401 accagtccta gtgagtctaa gctgcccagc agtcttggag gcatctgaga ggacagattc 2461 tccacagaat tctaaaaacc cacactcaac atgggcagtc aagcaaagac tgggaccttt 2521 ggagagcctc tggaatgaga gttctctggg gtacttccaa agggagctgg cagtcagtcc 2581 aggggaccta aaggaatttg gttgaacagt atcatctctg tgcatagtaa gagggaatgt 2641 tgggtggtcc gggcagtttc caatatggca aagcatctgc ttggacagtg ccagcaagcc 2701 ttcctctgac ccagtctcca atgtccacta acttataaaa atgtcatcaa ctcccacatg 2761 tgagaaacac catgatttgt actgtgcatg ggtcacattc ttattctaga aatgcatcac 2821 cctgtgttta tccaagtgtg tttacttggt gtaatgtcca gtagtaatag aatatgaaat 2881 atcaaggaac catctttgtt acgtgacttc caaaatgtga gatctcattg ctgtcactgt 2941 gatatttgta ttgtgtgaat ctcttcctcc tcttcctcct catgctttct cagggaggag 3001 ccctgatgta tatcatgaac tcacagttcc tagaccacag taattgaggg gcggtggggg 3061 ggcctttatc ggagaagcta gagaacaaga gtccttctcc tccttatccc ccaacaggac 3121 actaagagac aaggactgag tggaatcctg gagaaagggg actcaggaac tgacctcatt 3181 ggcctgattt gtgaggagag gagtataagt ggagaggggc cattcctgag gtttccgtgt 3241 tttccagcct ggtctcctgg aaagaatctt tatacagaaa taaagtatgt gtttcactct 3301 ctcgtgcctc tgtctcttct ctaggggtcc taaacatcct ataggatgct aaatgggatg 3361 gtactagaaa ccctaataac ttgcatagct agaaggatgg aatcaatgtt cagtaaactc 3421 ttgactctgt gatgaaatgg gttgggaaga tgtgggaaca gttcccaggt tgagatctgg 3481 gaagggaggt gggattatgc gaaatcacag tgatgttgcc tatgaataaa gctgtgtcag 3541 gatgcagaca caacagagtt ataagcacaa gggagttttc gtaggacagg aggttggggg 3601 gaataacatc tgagaaagac aaaggggaaa gaaagcagaa gtactcaggg acagccttca 3661 gaccaccatg ccaatctgac acctgggaaa aaaggggtgg ttaggaagag cctcagactg 3721 tggtgcagct cccagcccaa cacgtgcaaa gattgcccag agagacattg cacgttaaca 3781 gaatggccag gcctgatgcc ctgccgtgct cagccgctgg ctggggctct ctagggaaag 3841 tgttctgtgt ttgaacacca tggtggatgc tgaagccctg cagctggagg ctgtcagcca 3901 agtgccctgc agttcttcct aaagaggga

(2) INFORMATION FOR SEQ ID NO:2640: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2581 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2640

1 gaaaaagcct tccaccctcc tgtctggctt tagaaggacc ctgagcccca ggcgccacga

61 caggactctg ctgcagaggg gggttgtgta cagatagtag ggctttaccg cctagcttcg

121 aaatggataa cgtcctcccg gtggactcag acctctcccc aaacatctcc actaacacct

181 cggaacccaa tcagttcgtg caaccagcct ggcaaattgt cctttgggca gctgcctaca

241 cggtcattgt ggtgacctct gtggtgggca acgtggtagt gatgtggatc atcttagccc

301 acaaaagaat gaggacagtg acgaactatt ttctggtgaa cctggccttc gcggaggcct

361 ccatggctgc attcaataca gtggtgaact tcacctatgc tgtccacaac gaatggtact

421 acggcctgtt ctactgcaag ttccacaact tcttccccat cgccgctgtc ttcgccagta

481 tctactccat gacggctgtg gcctttgata ggtacatggc catcatacat cccctccagc

541 cccggctgtc agccacagcc accaaagtgg tcatctgtgt catctgggtc ctggctctcc EPI-109 802

601 tgctggcctt cccccagggc tactactcaa ccacagagac catgcccagc agagtcgtgt 661 gcatgatcga atggccagag catccgaaca agatttatga gaaagtgtac cacatctgtg 721 tgactgtgct gatctacttc ctccccctgc tggtgattgg ctatgcatac accgtagtgg 781 gaatcacact atgggccagt gagatccccg gggactcctc tgaccgctac cacgagcaag 841 tctctgccaa gcgcaaggtg gtcaaaatga tgattgtcgt ggtgtgcacc ttcgccatct 901 gctggctgcc cttccacatc ttcttcctcc tgccctacat caacccagat ctctacctga 961 agaagtttat ccagcaggtc tacctggcca tcatgtggct ggccatgagc tccaccatgt 1021 acaaccccat catctactgc tgcctcaatg acaggttccg tctgggcttc aagcatgcct

1081 tccggtgctg ccccttcatc agcgccggcg actatgaggg gctggaaatg aaatccaccc 1141 ggtatctcca gacccagggc agtgtgtaca aagtcagccg cctggagacc accatctcca 1201 cagtggtggg ggcccacgag gaggagccag aggacggccc caaggccaca ccctcgtccc 1261 tggacctgac ctccaactgc tcttcacgaa gtgactecaa gaecatgaca gagagcttea 1321 gcttctcctc caatgtgctc tcctaggcca cagggccttt ggcaggtgca geecceactg 1381 cctttgaeet gcctcccttc atgeatggaa attcccttca tctggaacca tcagaaacac 1441 cctcacactg ggacttgcaa aaagggtcag tatgggttag ggaaaacatt ccatccttga 1501 gtcaaaaaat ctcaattctt ccctatcttt gccaccctca tgctgtgtga ctcaaaccaa 1561 atcactgaac tttgctgagc ctgtaaaata aaaggtcgga ccagcttttc ccaaaagccc 1621 attcattcca ttctggaagt gactttggct gcatgcgagt gctcatttca ggat

1 aattcagagc caccgcgggc aggcgggcag tgcatccaga agcgtttata ttctgagcgc

61 cagttcagct ttcaaaaaga gtgctgccca taaaaagcct tccaccctcc tgtctgcttt

121 agaaggaccc tgagccccag gcgccagcca caggactctg ctgcagaggg gggttgtgta

181 cagatagtag gctttacgcc tagcttcgaa atggataacg tcctcccggt ggactcagac

241 ctctccccaa acatctccac taacacctcg gaacccaatc agttcgtgca accagcctgg

301 caaattgtcc tttgggcagc tgcctacacg gtcattgtgg tgacctctgt ggtgggcaac

361 gtggtagtga tgtggatcat cttagcccac aaaagaatga ggacagtgac gaactatttt

421 ctggtgaacc tggccttcgc ggaggcctcc atggctgcat tcaatacagt ggtgaacttc

481 acctatgctg tccacaacga atggtactac ggcctgttct actgcaagtt ccacaacttc

541 tttcccatcg ccgctgtctt cgccagtatc tactccatga cggctgtggc ctttgatagg

601 tacatggcca tcatacatcc cctccagccc cggctgtcag ccacagccac caaagtggtc

661 atctgtgtca tctgggtcct ggctctcctg ctggccttcc cccagggcta ctactcaacc

721 acagagacca tgcccagcag agtcgtgtgc atgatcgaat ggccagagca tccgaacaag

781 atttatgaga aagtgtacca catctgtgtg actgtgctga tctacttcct ccccctgctg

841 gtgattggct atgcatacac cgtagtggga atcacactat gggccagtga gatccccggg

901 gactcctctg accgctacca cgagcaagtc tctgccaagc gcaaggtggt caaaatgatg

961 attgtcgtgg tgtgcacctt cgccatctgc tggctgccct tccacatctt cttcctcctg

1021 ccctacatca acccagatct ctacctgaag aagtttatcc agcaggtcta cctggccatc

1081 atgtggctgg ccatgagctc caccatgtac aaccccatca tctactgctg cctcaatgac

1141 aggttccgtc tgggcttcaa gcatgccttc cggtgctgcc ccttcatcag cgccggcgac

1201 tatgaggggc tggaaatgaa atccacccgg tatctccaga cccagggcag tgtgtacaaa

1261 gteagccgcc tggagaccae catctccaca gtggtggggg cccacgagga ggagccagag

1321 gacggcccca aggccacace ctcgtccctg gacctgacet ccaactgctc ttcacgaagt

1381 gactccaaga ccatgacaga gagettcagc ttctcctcca atgtgctctc ctaggccaca

1441 gggcctttgg caggtgcagc ccccactgcc tttgacctgc ctcccttcat gcatggaaat

1501 tcccttcatc tggaaccatc agaaacaccc tcacactggg acttgcaaaa agggtcagta

1561 tgggttaggg aaaacattcc atccttgagt caaaaaatct caattcttcc ctatctttgc

1621 caccctcatg ctgtgtgact caaaccaaat cactgaactt tgctgagcct gtaaaataaa

1681 aggtcggacc agcttttcct caagagccca atgcattcca tttctggaag tgactttggc

1741 tgcatgcgag tgctcatttc aggatg

1 gaaaaagcct tccaccctcc tgtctggctt tagaaggacc ctgagcccca ggcgccacga

61 caggactctg ctgcagaggg gggttgtgta cagatagtag ggctttaccg cctagcttcg

121 aaatggataa cgtcctcccg gtggactcag acctctcccc aaacatctcc actaacacct

181 cggaacccaa tcagttcgtg caaccagcct ggcaaattgt cctttgggca gctgcctaca

241 cggtcattgt ggtgacctct gtggtgggca acgtggtagt gatgtggatc atcttagccc

301 acaaaagaat gaggacagtg acgaactatt ttctggtgaa cctggccttc gcggaggcct

361 ccatggctgc attcaataca gtggtgaact tcacctatgc tgtccacaac gaatggtact

421 acggcctgtt ctactgcaag ttccacaact tcttccccat cgccgctgtc ttcgccagta

481 tctactccat gacggctgtg gcctttgata ggtacatggc catcatacat cccctccagc

541 cccggctgtc agccacagcc accaaagtgg tcatctgtgt catctgggtc ctggctctcc

601 tgctggcctt cccccagggc tactactcaa ccacagagac catgcccagc agagtcgtgt

661 gcatgatcga atggccagag catccgaaca agatttatga gaaagtgtac cacatctgtg

721 tgactgtgct gatctacttc ctccccctgc tggtgattgg ctatgcatac accgtagtgg

781 gaatcacact atgggccagt gagatccccg gggactcctc tgaccgctac cacgagcaag

841 tctctgccaa gcgcaaggtg gtcaaaatga tgattgtcgt ggtgtgcacc ttcgccatct

901 gctggctgcc cttccacatc ttcttcctcc tgccctacat caacccagat ctctacctga

961 agaagtttat ccagcaggtc tacctggcca tcatgtggct ggccatgagc tccaccatgt

1021 acaaccccat catctactgc tgcctcaatg acaggtgagg atcccaaccc catgagctct

1081 ccaggggcca caagaccatc tacatacaca gtggccaagc ggcatcctaa atgagtaaac

1141 ccagctgtga gacaagaggg acaagtgggg actgcagcta acttatcatc acacaactca EPI-109 803

1201 gcctggctga ttatcaccat ccaggaatgg gagcccggag tagactgatt ttcttttttt 1261 cttttcca

1 atgctgagaa aggtagctgc caaaccttga ctgcaataac aataacaaaa attaaaaacc

61 taaaataata agtatatcat actgaccttt cctgtttacc ttgctgtagg taccacatct

121 gtgtgactgt gctgatctac ttcctccccc tgctggtgat tggctatgca tacaccgtag

181 tgggaatcac actatgggcc agtgagatcc ccggggactc ctctgaccgc taccacgagc

241 aagtctctgc caagcgcaag gtgagcaggg gacaggcaga actaacccac cctggcacag

301 acaacaggct gtcgagaagg gatggcacac ttgtgagccc cagaggcagc tagcacaaaa 361 tatccccagg tat

1 ggatccaatt tttgcccggc ataagtgtat agtaaatttc ccagccttaa agcacttccc

61 gagagatgct ttgagcgctc gcggtaccag tgcgtaaacg ccgctccccg gctggcgcgg

121 gtgtgcgcca actccaacct gcgcgcaagt ctgccggtgc gcgctccagt cccacagctc

181 cgagtccccg cagtgaaagg agggggcggt gcaccggggt agatgggccc ctgaggactc

241 ccggggttca gttttccgcg gctgccaaga gggccaagtt ggacagtggc agggtcctga

301 agcagatcag caacaaccgc aagtgctcca gccccaggtc ctcagacacg gaggaaaacg

361 acaagaggcg gacacacaac gtcttggaac gtcagaggag gaacgagctg aagcgcagct

421 tttttgccct gcgtgaccag atccctgaat tggaaaacaa cgaaaaggcc cccaaggtag

481 tgatcctcaa aaaagccacc gcctacatcc tgtccattca agcagacgag cacaagctca

541 cctctgaaaa ggacttattg aggaaacgac gagaacagtt gaaacacaaa ctcgaacagc

601 ttcgaaactc tggtgcataa actgacctaa ctcgaggagg agctggaatc tctcgtgaga

661 gtaaggagaa cggttccttc tgacagaact gatgcgctgg aattaaaatg catgctcaaa

721 gcctaacctc acaaccttg^'g ctggggcttt gggactgtaa gcttagagac tgtcacttcc

781 caggtgaatc agctagccag gtaactgagc tagatatttt gtgggggtgt ttcctaaaca

841 cagcctcagg aaagttgttt tcgggacacc tggaccaggg agtcgtcgcc tctggcttct

901 cggtagctgg agcgcggccc ggagcgcggc gctggcacat cgcccccaca catgaccgtt

961 tcccattgcc acaggcaagc cgcctctgca gagctgtctc agggctctgg gcttcattcc

1021 ctggaagttg attgtcctcc actccagctg tttcccaaat ccttccttcc tcccagcacc

1081 cctcgtgcaa cgacgattcc agctgcggac cgcatctgtg tcagttactt ccaagccacc

1141 tactgccccc tcgcggagtg cgtggggctc ccggctcgca gactcccacg gcaagtagca

1201 agcagcaaaa ggcgtggtag ctgcggcggt ggaatgagac agttgtcaac agctggcgca

1261 cgtgccgccg tgcgcaccgg gactggcgag tacgcagccc aggtactgcc ccttcccagt

1321 gacgtctctg cagggggtta taaaagcctc gtgcgcagct aactcgcgag ctgagcaacc

1381 cgaaccgaga ggtgcccgcg aaactgcagg cggcggcagc ggcagcaaaa gagaaggaaa

1441 aatctccagc tggatacgaa gctccagaat cctggccata ggctcagaac ttttacaggt

1501 cgcgctgcaa tgggccccca cttcgctcct aagtcctcac gcagcacagg gctttgcctt

1561 tccctgcgga ggaaggagaa ataggagttg caggcagcag caggtgcata aatgcggggg

1621 atctcttgct tcctagaact gtgaccggtg gaatttcttt ccctttttca gtttaccgca

1681 agagagatgc tgtctccaga cttctgaact caaacgtctc ctgaagcttg aaagtggagg

1741 aattcagagc caccgcgggc aggcgggcag tgcatccaga agcgtttata ttctgagcgc

1801 cagttcagct ttcaaaaaga gtgctgccca gaaaaagcct tccaccctcc tgtctggctt

1861 tagaaggacc ctgagcccca ggcgccagcc acaggactct gctgcagagg ggggttgtgt

1921 acagatagta gggctttacc gcctagcttc gaaatggata acgtcctccc ggtggactca

1981 gacctctccc caaacatctc cactaacacc tcggaaccca atcagttcgt gcaaccagcc

2041 tggcaaattg tcctttgggc agctgcctac acggtcattg tggtgacctc tgtggtgggc

2101 aacgtggtag tgatgtggat catcttagcc cacaaaagaa tgaggacagt gacgaactat

2161 tttctggtga acctggcctt cgcggaggcc tccatggctg cattcaatac agtggtgaac

2221 ttcacctatg ctgtccacaa cgaatggtac tacggcctgt tctactgcaa gttccacaac

2281 ttcttcccca tcgccgctgt cttcgccagt atctactcca tgacggctgt ggcctttgat

2341 aggtgagatt agcctttgtg aaaaggcgag aaagtgctca tagaggacca tggcattgct

2401 gtgaggtttg gaactgggtg gggtatgggt caagtggaag attggccact ctgagggttt

2461 ttttactgat ca

1 agaatatgga aaaggaattg gaaaataatt gtacaaatca tcaggaatca aagggtttct

61 atgaattttc ttattggcag gaaaaatatg gaatctctga tacagatttt ggtgaccaga

121 tcagaacttt gttctttctt ctctgttcca ggtacatggc catcatacat cccctccagc

181 cccggctgtc agccacagcc accaaagtgg tcatctgtgt catctgggtc ctggctctcc

241 tgctggcctt cccccagggc tactactcaa ccacagagac catgcccagc agagtcgtgt

301 gcatgatcga atggccagag catccgaaca agatttatga gaaagtgtga gtagagatga

361 ctccccatgc caaagaaacg atggtgcagg ctgccttcct ggccccttct tgctctttct

421 ttctttccat attcttttgt tggtacagat ttaatgtgta tctgcaagca tttctcacat

481 ataccctcat atcaggttga tatgtccaca gttgtcaggg gactatagta tcccaaatac

541 tattctgagc attgaaagat aatttttgaa gtgtaagatc tagatcctgt tata

1 gagggggatg tgctggtggt ctcacctgtc tcaccctctt gccaggtggt caaaatgatg

61 attgtcgtgg tgtgcacctt cgccatctgc tggctgccct tccacatctt cttcctcctg

121 ccctacatca acccagatct ctacctgaag aagtttatcc agcaggtcta cctggccatc

181 atgtggctgg ccatgagctc caccatgtac aaccccatca tctactgctg cctcaatgac

241 aggtgaggat cccaacccca tgagctctcc aggggccaca agaccatcta catacacagt

301 ggccaagcgg catctaaatg agtaaaccca gctgtgagac aagagggaca agtggggact 361 gcagctaact t EPI-109 804

1 ccgtcccaaa ggtcacctct tcatctgctc gctctccagg ttccgtctgg gcttcaagca

61 tgccttccgg tgctgcccct tcatcagcgc cggcgactat gaggggctgg aaatgaaatc

121 cacccggtat ctccagaccc agggcagtgt gtacaaagtc agccgcctgg agaccaccat

181 ctccacagtg gtgggggccc acgaggagga gccagaggac ggccccaagg ccacaccctc

241 gtccctggac ctgacctcca actgctcttc acgaagtgac tccaagacca tgacagagag

301 cttcagcttc tcctccaatg tgctctccta ggccacaggg cctttggcag gtgcagcccc

361 cactgccttt gacctgcctc ccttcatgca tggaaattcc cttcatctgg aaccatcaga

421 aacaccctca cactgggact tgcaaaaagg gtcagtatgg gttagggaaa acattccatc

481 cttgagtcaa aaaatctcaa ttcttcccta tctttgccac cctcatgctg tgtgactcaa

541 accaaatcac tgaactttgc tgagcctgta aaataaaagg tcggaccagc ttttcccaaa

601 agcccattca ttccattctg gaagtgactt tggctgcatg cgagtgctca tttcaggatg

661 aattctgcag cacagctgcg gacccggaag actcattttc ctggagcccc gtgttacttc

721 aataaagtta tctcagatta gcctcctgca gctggaggct cctatcaccc cagcctacgc

781 ttgacagggt gaacaaaaga aggcaccaca taacatctaa atgaaaaatt tagccctgtc

841 ttctaagcat ctgtgaaaag aaacatatgt attccccttt ttggcatctc agtatttcag

901 tacatttata catcatgaga ttgagaacct cgggcttcca cattatgtcc ccggtgactg

961 tcctgagcag ccgacgcaag cagaatatgt ccactgatac ctgctagttc tcttacagac

1021 caggaattgg gagacttgca ctacatttaa tgtgtagttg accctctttt cctacttgta

1081 aacaagggga ctgaactaga taatctaagt gttccttcga atcttaacat cccgtggttc

1141 aaggattgta tgagtttttt gtttgtttta caaaaaaaaa caaaacgaag aataaaagaa

1201 tagaaaagaa taggagcagt gagtcttgta actaataccc agttcctgga gatgtagcaa

1261 ctgctaaggc catctgtaac tatccatctc agacattctc cgatttatct taaaatcctg

1321 agtacattcc ttctcatgga aggttttggc ttttgacaga gcagaggact tcatgccaag

1381 gcctgcatcc atccagcttt agcaggcaga atttcatagc tgcagaacac tgtcagagaa

1441 gacaaatgtg ggctccctgc tttaaccttt tgggtatttt agggtggggg ccctaacctt

1501 cattcttagt tttacactag catcgtgctc atatgtgcga caagcaagaa ggctgcactt

1561 tgcagctgca cttctgggaa gagggcatct tgcatcttcc cttcagactc tctgaatgtc

1621 tcctccctgc tccatggctt tgccagcttc ctgtctctaa ggggtagaat gactcatcaa

1681 ccctaaagga cagtcagtc.t tccaagagcc atgaactgaa tgctttatat cctaatttag

1741 atttagagtt tccagaaggt gagcatgcag ttttgttttg tttttttttc tgtctcccaa

1801 atctgtgttt tttccagata tggctggaag cagaagcttc atgtaacatc catgaatgtc

1861 ctcctggtag tttgcataat ggatgcacat gtgccgcatc cataacatta aggggagaat

1921 aatgcatggt ttacagcctt tgccagccct gctggctcta attctaccag ggcatccaca

1981 ggcctggggg aagaagaaac agtataagcc agaaaacctc aagaactaca ttctctaaag

2041 cagcatggaa agttttaaat aaactaagtg aagccagatc attgcagata tataaatgga

2101 agacaaaatt tagaagcaac aaaagttagt gccctaagca ttagtcatac ttccaataga

2161 gaatcttgct gtgtatggat tactcacttt ggaagaatgt aaagagctaa catgattatg

2221 agaagtacct gagaagatgg tgtcaagaag ttggggacac cccatctatg gaagagaagg

2281 ttagagttga gctcaacgag gattaactga gtgcctcctc tggactttgc cctgaactgg

2341 gaacacacag cccctgcagc tcttgaagag cctaccttat tggccatcac taactaactc

2401 accagtccta gtgagtctaa gctgcccagc agtcttggag gcatctgaga ggacagattc

2461 tccacagaat tctaaaaacc cacactcaac atgggcagtc aagcaaagac tgggaccttt

2521 ggagagcctc tggaatgaga gttctctggg gtacttccaa agggagctgg cagtcagtcc

2581 aggggaccta aaggaatttg gttgaacagt atcatctctg tgcatagtaa gagggaatgt

2641 tgggtggtcc gggcagtttc caatatggca aagcatctgc ttggacagtg ccagcaagcc

2701 ttcctctgac ccagtctcca atgtccacta acttataaaa atgtcatcaa ctcccacatg

2761 tgagaaacac catgatttgt actgtgcatg ggtcacattc ttattctaga aatgcatcac

2821 cctgtgttta tccaagtgtg tttacttggt gtaatgtcca gtagtaatag aatatgaaat

2881 atcaaggaac catctttgtt acgtgacttc caaaatgtga gatctcattg ctgtcactgt

2941 gatatttgta ttgtgtgaat ctcttcctcc tcttcctcct catgctttct cagggaggag

3001 ccctgatgta tatcatgaac tcacagttcc tagaccacag taattgaggg gcggtggggg

3061 ggcctttatc ggagaagcta gagaacaaga gtccttctcc tccttatccc ccaacaggac

3121 actaagagac aaggactgag tggaatcctg gagaaagggg actcaggaac tgacctcatt

3181 ggcctgattt gtgaggagag gagtataagt ggagaggggc cattcctgag gtttccgtgt

3241 tttccagcct ggtctcctgg aaagaatctt tatacagaaa taaagtatgt gtttcactct

3301 ctcgtgcctc tgtctcttct ctaggggtcc taaacatcct ataggatgct aaatgggatg

3361 gtactagaaa ccctaataac ttgcatagct agaaggatgg aatcaatgtt cagtaaactc

3421 ttgactctgt gatgaaatgg gttgggaaga tgtgggaaca gttcccaggt tgagatctgg

3481 gaagggaggt gggattatgc gaaatcacag tgatgttgcc tatgaataaa gctgtgtcag

3541 gatgcagaca caacagagtt ataagcacaa gggagttttc gtaggacagg aggttggggg

3601 gaataacatc tgagaaagac aaaggggaaa gaaagcagaa gtactcaggg acagccttca

3661 gaccaccatg ccaatctgac acctgggaaa aaaggggtgg ttaggaagag cctcagactg

3721 tggtgcagct cccagcccaa cacgtgcaaa gattgcccag agagacattg cacgttaaca

3781 gaatggccag gcctgatgcc ctgccgtgct cagccgctgg ctggggctct ctagggaaag

3841 tgttctgtgt ttgaacacca tggtggatgc tgaagccctg cagctggagg ctgtcagcca

3901 agtgccctgc agttcttcct aaagaggga

(2) INFORMATION FOR SEQ ID NO: 2641: EPI-109 805

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2641

1 gggtctcaag gaatctttat tctgcgtctt cattctgaac tggatggaac cttcctgagc

61 gcagagtcct ttccactgtg aattatgggt ttgttatcgt ttttgttcgt tgctggttgt

121 acgtgacggg agttcagctt tttgctgcgg gacggcagag ataggatgcg gggcttcctg

181 agaggcgccg gggcagggcc gcacaggtcc atccacctcc cctgggaccc cagccctgca

241 gcagccccag gggagcggcc ggggatcggg gcggggtgcc caggacgcgc cctgattggc

301 ccagtgttag ccaatcaagg ctctcgcatc cccatggtgc tgattggtcc gcctcccagg

361 cctgacccaa tcggagcatt cctaggagga gcggccccag agcgcctgac tcgggggtcc

421 cagagccctc tgcacaccac agccccggtg tccccgtgtg tccctgggtt ctcccagccc

481 tggtgtcccc tgagtctctt cttcaccgtc agccctggtg tctcccgtgt ccctgccaca

541 ccctcatccc tggtgtcccc cgtcacccca tcccctcacc tcctgggctc ctgaaggtcc

601 catcttgtgg gcctcattca tggaaccagg acggggcagg tggaggcctc tggggagttt

661 gtccagagaa tggaggagaa gcagggtcat gagcaggagc ggtctgggcc acccctgcct

721 gtcccccggg gggtgcagcc cggaaggagt ccagatggat atggccccgc agtgcagagt

781 cagccccaaa ccaggctggt cccaggcagg gtgggggcag gaggagcccc ggagtggccc

841 tgtgttgggg gtcggggggc aggcaggggg tcctggggct cagaagcgga ggaggtgggc

901 tggaggcccc agtgaccaac aggcccacgg gagtcgggag gtggggtgga cggacctgca

961 gggacagtgt cagcgctgaa tgggatggag agcacaggga gctggggccg gggatgagac

1021 catggggagc tggggctggg gctgggacta gtccatgggg agctggggct gaagttgggg

1081 gtgagtccat ggggagctgg gctgggcctc ctggggttgc acctgcactc ctctctgctc

1141 ttccctctgc gtatgaagct cagatcccat gataaggagg cacctgcaga ccaggggacc

1201 tgcacggaca gccccagagg tggacattga ggactcgtag gaggacttgg gtctcatacg

1261 gcgggtgggg agcagggccc cttcctggct gaggacactt ggtgctgtcc cctctcaagg

1321 ctgtttcccc atctgacaaa ggggtctcat gtgagccccc aaccaagtga gtcgaggagg

1381 gctggcccca cccccgtgga tttggagtcc gtaggagggg tgtcacccgt cacgtcccca

1441 ccccgtgggc accttcccgt ctcttggagc gtggcccatg gacatgagtt cctcacccgt

1501 gtccctcttg gggaaacagg tttcaggagc gacgggtctt gtagcctggg gcagccaggc

1561 cacctgggtg cagctatgcc tgaaggcctc ctggcaccga gacaggggca ggagcagatc

1621 ccaccagcgg gaaggtggtg cgttctgatg ctgggatcca ccagctgaca ggtggagctg

1681 cgagcctcca gtgctcagcc ctcggcgggg cctgcctggc agccccacac acagagggca

1741 tcggggtggc gggggcacgt gttacacggg ggccctgggt ctgagtcatc cacttcctcc

1801 gagtctggat gggaggaccc agcgcccctc ctccgccccc tcctgatctg gaaggataaa

1861 tggggagggg agagcccgct gggtagaagg aacagggagt ggccagggta agtccctact

1921 ctcagagacc ctgacatcag tgtcacctgg agcagagtgg cccagcctca gactcagagc

1981 accaagaccc aggcccgcag gcctggaccc accccggtcc ccccgtccca gctccattct

2041 tcaccccaca atctgtagcc cccagccctg ccctgtgagg cccggccagg cccacgatgc

2101 tcctccttgc tccccagatg ctgagcctgc tgctgctggc gctgcccgtc ctggcgagcc

2161 cggcctacgc ggcccctggt gagtcccagc cggggtccac cctgcccctc accacattcc

2221 acaggtcagg gcctgggtgg gttctgggga ggctgggctg gcccccacac agggaagggc

2281 tgggcccagg cgtggggctg cttcctggtc ctgacctggc acctgcccca gccccagtcc

2341 aggccctgca gcaagcgggt atcgtcgggg gtcaggaggc ccccaggagc aagtggccct

2401 ggcaggtgag cctgagagtc cgcgaccgat actggatgca cttctgtggg ggctccctca

2461 tccaccccca gtgggtgctg accgcggcgc actgcctggg accgtgagtc tcccagggcc

2521 tggaggggtg ggcaagggct ggatgtgagc cctggctccc gggtgctcct gggggctgcc

2581 cagggccctg agtgggatcc tccgctgccc agggacgtca aggatctggc caccctcagg

2641 gtgcaactgc gggagcagca cctctactac caggaccagc tgctgccggt cagcaggatc

2701 atcgtgcacc cacagttcta catcatccag actggagcgg atatcgccct gctggagctg

2761 gaggagcccg tgaacatctc cagccgcgtc cacacggtca tgctgccccc tgcctcggag

2821 accttccccc cggggatgcc gtgctgggtc actggctggg gcgatgtgga caatgatggt

2881 gggtctgggg acagtgggag gtggggccag ggtcttagcc acagcccagc ccctgggctc

2941 caggtggggg ttgcccggcc ccctcctcag gctgcaccct cttccccacc tgcagagccc

3001 ctcccaccgc catttcccct gaagcaggtg aaggtcccca taatggaaaa ccacatttgt

3061 gacgcaaaat accaccttgg cgcctacacg ggagacgacg tccgcatcat ccgtgacgac

3121 atgctgtgtg ccgggaacac ccggagggac tcatgccagg tgggccccgc gtgtcccccg

3181 ccccccgcac cccaaccccc actcccaggc ctgttcggcg agcgctgacc tctgaccttc

3241 ccagggcgac tctggagggc ccctggtgtg caaggtgaat ggcacctggc tacaggcggg

3301 cgtggtcagc tgggacgagg gctgtgccca gcccaaccgg cctggcatct acacccgtgt

3361 cacctactac ttggactgga tccaccacta tgtccccaaa aagccgtgag tcaggcctgg

3421 ggtgtccacc tgggtcactg gagagccagc ccctcctgtc caaaacacca ctgcttccta

3481 cccaggtggc gactgccccc cacaccttcc ctgccccgtc ctgagtgccc cttcctgtcc

3541 taagccccct gctctcttct gagccccttc ccctgtcctg aggacccttc cccatcctga

3601 gcccccttcc ctgtcctaag cctgacgcct gcactgggcc ctccggccct cccctgccca

3661 ggcagctggt ggtgggcgct aatcctcctg agtgctggac ctcattaaag tgcatggaaa

3721 tcactggtgt gcatcgctgt gtttctggtt gtggatgtca ctgggagaga aggggtccag EPI-109 806

3781 gtgtgctgag gacacctgcc acagtgcgag gtcctagccc tcaaggcaca gccagtcacc 3841 gtgggacggg gcctcctggg cagccctggt ccccggggct ggcttctccc cacacgatgc 3901 atccagcatt cgggtcacac agagccactc gggcaactca gttgattata aaggacagcc 3961 aagtccctgc aaccgggtca agacagagaa tggtcgccgg gagccccagg gctgcccatc 4021 acgagcccct accccacgct tcccacgagc tcttctcccg gcccctctgt ccactgcttg 4081 tgctttgccc tagttgtttg ctttgagaca ggatctcgct gtgtcatcca ggctgaagtg 4141 cagtggtgtg atcagggctc actgtagcct tgaactcctg ggctcaagcg atcctcccat 4201 cttggcctcc catatagctg ggccacagga gtgagccacc acgcccagtt aatttttgta 4261 ttttcagtag agatggggtt tcgccatgtt ggccagtctg gtctcgaact cctgacctca 4321 agtgatctgc ccgcctcggc ctcccaaagt gctgggatga caggcgtgag ccaccgcacc 4381 cagcctgagt ttgacatttt caaattcatt ttgaggtctt tctctacatc aatacatgag 4441 ccctccgcgt ccggcgagtg ttgcatttta tcccgggctc ttgtttgcat tttatatttg 4501 aacatgatta cattcaggaa tgaaatgcgg ggctgttctg gttgaaaaca actctctaaa 4561 gaaacattca ctctttcctt ccaactgtca gatgcagaga tgtgcattta gtctctccaa 4621 tctctgcaaa tgacctctgt cctcacaagg ggtggactcg acttccagcg ccctctccag 4681 ccccacgtga cctctgcctc tgcagcccct gaaggcccat ccctcggctc ctgttctgca 4741 ggcccagcgt cttgtctatg aagatggacc tggaactcgg gccctccttc ctccctctgg 4801 cccatcccac cttctaggga tcacagagac agcacggggt gacccccagg gaacactgag 4861 cccctagaag cacttccaca cgcccactgg aggttttgcg gggtgggagt cggagggatg 4921 agaccccgaa gggaagcaag acggcccctc aggacagggc tgccggtgta aggaaaggtg 4981 gacagcaggg gccggtcact gggtggaggg ggagggcagg ctccagcccc agagcttccc 5041 aaattagatc taagatccct gggaagctca gtgaagctca gcgcagtgac actggcagat 5101 gtgagcgtca gcttcagcag gaagggtctc tcaggacgtg acaggcaggc tgctggccag 5161 ggctgcagcc acctgcgttt tgactgggac gggggcacct gatccaaggt cacccacgtg 5221 gctgccggca ggaggccctg gttccccgtc acaagggggt gtgaggggga aggccaagtg 5281 gtggccacan ggttnccacc gagagggaca gtgcccaagt tggccaagcc accctnggac 5341 aagaaacaat nccaagtctt nccaaggtcc ttggacaaca aggagaancc cccccagctt 5401 gggggcnatt aaccaagggc cangnccccc cttcccggtt c

(2) INFORMATION FOR SEQ ID NO: 2642: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2642

1 tggacccacc ccggtccccc cgtcccagct tccattcttc accccacaat ctgtagcccc 61 cagccctgcc ctgtgaggcc cggccaggcc cacgatgctc ctccttgctc cccagatgct 121 gaatctgctg ctgctggcgc tgcccgtcct ggcgagccgc gcctacgcgg cccctggtga 181 gtcccagccg gggtccaccc tgcccctcac cacattccac aggtcagggc ctgggtgggt 241 tctggggagg ccgggctggc ccccacacag ggaagggctg ggcccaggcc tggggctgct 301 tcctggtcct gacctggcac ctgccccagc cccaggccag gccctgcagc gagtgggcat 361 cgttgggggt caggaggccc ccaggagc

(2) INFORMATION FOR SEQ ID NO: 2643: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2643

1 cagatcggag cggacatcgc cctgctggag ctggaggagc cggtgaaggt ctccagccac

61 gtccacacgg tcaccctgcc ccctgcctca gagaccttcc ccccggggat gccgtgctgg

121 gtcactggct ggggcgatgt ggacaatgat ggtgggtctg gggacagtgg aggtggggcc

181 agggtcttag ccacagccca gcccctgggc tccctctggg ctccaggtgg gggttgcccg

241 gccccctcct gaggctgcac cctcttcccc acctgcagag cgcctcccac cgccatttcc

301 tctgaagcag gtgaaggtcc ccataatgga aaaccacatt tgtgacgcaa aataccacct

361 tggcgcctac acgggagacg acgtccgcat cgtccgtgac gacatgctgt gtgccgggaa

421 cacccggagg gactcatgcc aggtgggccc cgcgtgtccc ccgccccccg caccccaacc

481 cccactccca ggcctgttcg gcgagcgctg acctctgacc ttcccagggc gactccggag

541 ggcccctggt gtgcaaggtg aatggcacct ggctgcaggc gggcgtggtc agctggggcg

601 agggctgtgc ccagcccaac cggcctggca tctacacccg tgtcacctac tacttggact

661 ggatccacca ctatgtcccc aaaaagccgt gagtcaggcc tgggttggcc acctgggtca

721 ctggaggacc aacccctgct gtccaaaaca ccactgcttc ctacccaggt ggcgactgcc

781 ccccacacct tccctgcccc gtcctgagtg ccccttcctg tcctaagccc cctgctctct

841 tctgagcccc ttcccctgtc ctgaggaccc ttccccatcc tgagccccct tccctgtcct

901 aagcctgacg cctgcactgg gccctccggc cctcccctgc ccaggcagct ggtggtgggc

961 gctaatcctc ctgagtgctg gacctcatta aagtgcatgg aaatcactgg tgtgcatcgc

1021 tgtgtttctg gttgtggatg tcactgggag agaaggggtc caggtgtgct gaggacacct EPI-109 807

1081 gccacagtgt gaggtcctag ccctcaaggc acaagccagt caccgtggga cggggcctct 1141 gggcagccct ggtccccgag ctggctt

(2) INFORMATION FOR SEQ ID NO: 2644: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2644

1 ccaggatgct gaatctgctg ctgctggcgc tgcccgtcct ggcgagccgc gcctacgcgg

61 cccctgcccc aggccaggcc ctgcagcgag tgggcatcgt tgggggtcag gaggccccca

121 ggagcaagtg gccctggcag gtgagcctga gagtccacgg cccatactgg atgcacttct

181 gcgggggctc cctcatccac ccccagtggg tgctgaccgc agcgcactgc gtgggaccgg

241 acgtcaagga tctggccgcc ctcagggtgc aactgcggga gcagcacctc tactaccagg

301 accagctgct gccggtcagc aggatcatcg tgcacccaca gttctacacc gcccagatcg

361 gagcggacat cgccctgctg gagctggagg agccggtgaa ggtctccagc cacgtccaca

421 cggtcaccct gccccctgcc tcagagacct tccccccggg gatgccgtgc tgggtcactg

481 gctggggcga tgtggacaat gatgagcgcc tcccaccgcc atttcctctg aagcaggtga

541 aggtccccat aatggaaaac cacatttgtg acgcaaaata ccaccttggc gcctacacgg

601 gagacgacgt ccgcatcgtc cgtgacgaca tgctgtgtgc cgggaacacc cggagggact

661 catgccaggg cgactccgga gggcccctgg tgtgcaaggt gaatggcacc tggctgcagg

721 cgggcgtggt cagctggggc gagggctgtg cccagcccaa ccggcctggc atctacaccc

781 gtgtcaccta ctacttggac tggatccacc actatgtccc caaaaagccg tgagtcaggc

841 ctgggtgtgc cacctgggtc actggaggac caacccctgc tgtccaaaac accactgctt

901 cctacccagg tggcgactgc cccccacacc ttccctgccc cgtcctgagt gccccttcct

961 gtcctaagcc ccctgctctc ttctgagccc cttcccctgt cctgaggacc cttccccatc

1021 ctgagccccc ttccctgtcc taagcctgac gcctgcactg ctccggccct cccctgccca

1081 ggcagctggt ggtgggcgct aatcctcctg agtgctggac ctcattaaag tgcatggaaa

1141 tea

(2) INFORMATION FOR SEQ ID NO:2645: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2645

1 ggccaggatg ctgaatctgc tgctgctggc gctgcccgtc ctggcgagcc gcgcctacgc

61 ggcccctgcc ccaggccagg ccctgcagcg agtgggcatc gttgggggtc aggaggcccc

121 caggagcaag tggccctggc aggtgagcct gagagtccac ggcccatact ggatgcactt

181 ctgcgggggc tccctcatcc acccccagtg ggtgctgacc gcagcgcact gcgtgggacc

241 ggacgtcaag gatctggccg ccctcagggt gcaactgcgg gagcagcacc tctactacca

301 ggaccagctg ctgccggtca gcaggatcat cgtgcaccca cagttctaca ccgcccagat

361 cggagcggac atcgccctgc tggagctgga ggagccggtg aaggtctcca gccacgtcca

421 cacggtcacc ctgccccctg cctcagagac cttccccccg gggatgccgt gctgggtcac

481 tggctggggc gatgtggaca atgatgagcg cctcccaccg ccatttcctc tgaagcaggt

541 gaaggtcccc ataatggaaa accacatttg tgacgcaaaa taccaccttg gcgcctacac

601 gggagacgac gtccgcatcg tccgtgacga catgctgtgt gccgggaaca cccggaggga

661 ctcatgccag ggcgactccg gagggcccct ggtgtgcaag gtgaatggca cctggctgca

721 ggcgggcgtg gtcagctggg gcgagggctg tgcccagccc aaccggcctg gcatctacac

781 ccgtgtcacc tactacttgg actggatcca ccactatgtc cccaaaaagc cgtgagtcag

841 gcctgggttg gccacctggg tcactggagg accaacccct gctgtccaaa acaccactgc

901 ttcctaccca ggtggcgact gccccccaca ccttccctgc cccgtcctga gtgccccttc

961 ctgtcctaag ccccctgctc tcttctgagc cccttcccct gtcctgagga cccttcccca

1021 tcctgagccc ccttccctgt cctaagcctg acgcctgcac cgggccctcc ggccctcccc

1081 tgcccaggca gctggtggtg ggcgctaatc ctcctgagtg ctggacctca ttaaagtgca

1141 tggaa

(2) INFORMATION FOR SEQ ID NO: 2646: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2646

1 tgaatctgct gctgctggcg ctgcccgtcc tggcgagccg cgcctacgcg gcccctgccc

61 caggccaggc cctgcagcga gtgggcatcg tcgggggtca ggaggccccc aggagcaagt

121 ggccctggca ggtgagcctg agagtccacg gcccatactg gatgcacttc tgcgggggct

181 ccctcatcca cccccagtgg gtgctgaccg cagcgcactg cgtgggaccg gacgtcaagg EPI-109 808

241 atctggccgc cctcagggtg caactgcggg agcagcacct ctactaccag gaccagctgc

301 tgccggtcag caggatcatc gtgcacccac agttctacac cgcccagatc ggagcggaca

361 tcgccctgct ggagctggag gagccggtga acgtctccag ccacgtccac acggtcaccc

421 tgccccctgc ctcagagacc ttccccccgg ggatgccgtg ctgggtcact ggctggggcg

481 atgtggacaa tgatgagcgc ctcccaccgc catttcctct gaagcaggtg aaggtcccca

541 taatggaaaa ccacatttgt gacgcaaaat accaccttgg cgcctacacg ggagacgacg

601 tccgcatcgt ccgtgacgac atgctgtgtg ccgggaacac ccggagggac tcatgccagg

661 gcgactccgg agggcccctg gtgtgcaagg tgaatggcac ctggctgcag gcgggcgtgg

721 tcagctgggg cgagggctgt gcccagccca accggcctgg catctacacc cgtgtcacct

781 actacttgga ctggatccac cactatgtcc ccaaaaagcc gtgagtcagg cctgggttgg

841 ccacctgggt cactggagga ccaacccctg ctgtccaaaa caccactgct tcctacccag

901 gtggcgactg ccccccacac cttccctgcc ccgtcctgag tgccccttcc tgtcctaagc

961 cccctgctct cttctgagcc ccttcccctg tcctgaggac ccttccctat cctgagcccc

1021 cttccctgtc ctaagcctga cgcctgcacc gggccctcca gccctcccct gcccagatag

1081 ctggtggtgg gcgctaatcc tcctgagtgc tggacctcat taaagtgcat ggaaatc

(2) INFORMATION FOR SEQ ID NO: 2647: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2647

1 accagctgac aggtggagct gccagtctcc agtgctcagc cctcagcggg gcctgcctgg

61 cagccccaca cacagagggc atcggggtgg cgggggcacg tgttacacgg gggccctggg

121 tctgagtcat ccacttcctc cgagtctgga tgggaggacc cagcgcccct cctccgcccc

181 ctcctgatct ggaaggataa atggggaggg gagagccact gggtagaagg aacagggagt

241 ggccagggta agtccccact ctcagagacc ctgacatcag cgtcacctgg agcagagtgg

301 cccagcctca gactcagagc accaagaccc aggcccgcag gcctggaccc accccggtcc

361 ccccgtccca gctccattct tcaccccaca atctgtagcc cccagccctg ccctgtgagg

421 cccggccagg cccacgatgc tcctccttgc tccccagatg ctgaatctgc tgctgctggc

481 gctgcccgtc ctggcgagcc gcgcctacgc ggcccctggt gagtcccagc cggggtccac

541 cctgcccctc accacattcc acaggtcagg gcctgggtgg gttctgggga ggtcgggctg

601 gccccccaca cagggaaggg ctgggcccag gcctggggct gcttcctggt cctgacctgg

661 cacctgcccc agccccaggc caggccctgc agcgagtggg catcgtcggg ggtcaggagg

721 cccccaggag caagtggccc tggcaggtga gcctgagagt ccacggccca tactggatgc

781 acttctgcgg gggctccctc atccaccccc agtgggtgct gaccgcagcg cactgcgtgg

841 gaccgtgagt ctcccggggc ctggaggggt ggggaagggc tggatgtgag ccctggctcc

901 cgggtgctcc tgggggctgc ccagggccct gagtgggatc ctccgctgcc cagggacgtc

961 aaggatctgg ccgccctcag ggtgcaactg cgggagcagc acctctacta ccaggaccag

1021 ctgctgccgg tcagcaggat catcgtgcac ccacagttct acaccgccca gatcggagcg

1081 gacatcgccc tgctggagct ggaggagccg gtgaacgtct ccagccacgt ccacacggtc

1141 accctgcccc ctgcctcaga gaccttcccc ccggggatgc cgtgctgggt cactggctgg

1201 ggcgatgtgg acaatgatgg tgggtctggg gacagtggag gtggggccag ggtcttagcc

1261 acagcccagc ccctgggtcc ctctgggctc caggtggggg ttgcccggcc ccctcctgag

1321 gctgcaccct cttccccacc tgcagagcgc ctcccaccgc catttcctct gaagcaggtg

1381 aaggtcccca taatggaaaa ccacatttgt gacgcaaaat accaccttgg cgcctacacg

1441 ggagacgacg tccgcatcgt ccgtgacgac atgctgtgtg ccgggaacac ccggagggac

1501 tcatgccagg tgggccccgc ctgtcccccg ccccccgccc cccaaccccc actcccaggc

1561 ctgttcggcg agcgctgacc tctgaccttc ccagggcgac tccggagggc ccctggtgtg

1621 caaggtgaat ggcacctggc tgcaggcggg cgtggtcagc tggggcgagg gctgtgccca

1681 gcccaaccgg cctggcatct acacccgtgt cacctactac ttggactgga tccaccacta

1741 tgtccccaaa aagccgtgag tcaggcctgg gttggccacc tgggtcactg gaggaccaac

1801 ccctgctgtc caaaacacca ctgcttccta cccaggtggc gactgccccc cacaccttcc

1861 ctgccccgtc ctgagtgccc cttcctgtcc taagccccct gctctcttct gagccccttc

1921 ccctgtcctg aggacccttc cctatcctga gcccccttcc ctgtcctaag cctgacgcct

1981 gcaccgggcc ctccagccct cccctgccca gatagctggt ggtgggcgct aatcctcctg

2041 agtgctggac ctcattaaag tgcatggaaa tcactggtgt gcatcgctgt gtttctggtt

2101 gtggatgtca ctgggagaga aggggtccag gtgtgctgag gacacctgcc acagtgtgag

2161 gtcctagccc tcaaggcaca gccagtcacc gtgggac

(2) INFORMATION FOR SEQ ID NO: 2648: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2648 1 ggaattccgt ggccaggatg ctgagcctgc tgctgctggc gctgcccgtc ctggcgagcc EPI-109 809

61 gcgcctacgc ggcccctgcc ccagtccagg ccctgcagca agcgggtatc gtcgggggtc 121 aggaggcccc caggagcaag tggccctggc aggtgagcct gagagtccgc gaccgatact 181 ggatgcactt ctgcgggggc tccctcatcc acccccagtg ggtgctgacc gcggcgcact 241 gcctgggacc ggacgtcaag gatctggcca ccctcagggt gcaactgcgg gagcagcacc 301 tctactacca ggaccagctg ctgccagtca gcaggatcat cgtgcaccca cagttctaca 361 tcatccagac tggagcggat atcgccctgc tggagctgga ggagcccgtg aacatctcca 421 gccgcgtcca cacggtcatg ctgccccctg cctcggagac cttccccccg gggatgccgt 481 gctgggtcac tggctggggc gatgtggaca atgatgagcc cctcccaccg ccatttcccc 541 tgaagcaggt gaaggtcccc ataatggaaa accacatttg tgacgcaaaa taccaccttg 601 gcgcctacac gggagacgac gtccgcatca tccgtgacga catgctgtgt gccgggaaca 661 gccagaggga ctcctgcaag ggcgactctg gagggcccct ggtgtgcaag gtgaatggca 721 cctggctaca ggcgggcgtg gtcagctggg acgagggctg tgcccagccc aaccggcctg 781 gcatctacac ccgtgtcacc tactacttgg actggatcca ccactatgtc cccaaaaagc 841 cgtgagtcag gcctgggtgt gccacctggg tcactggagg accaacccct gctgtccaaa 901 acaccactgc ttcctaccca ggtggcgact gccccccaca ccttccctgc cccgtcctga 961 gtgccccttc ctgtcctaag ccccctgctc tcttctgagc cccttcccct gtcctgagga 1021 cccttcccca tcctgagccc ccttccctgt cctaagcctg acgcctgcac tgctccggcc 1081 ctcccctgcc caggcagctg gtggtgggcg ctaatcctcc tgagtgctgg acctcattaa 1141 agtgcatgga aatc

(2) INFORMATION FOR SEQ ID NO: 2649: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2649

1 gctgcccgtc ctggcgagcc gcgcctacgc ggcccctgcc ccaggccagg ccctgcagcg 61 agtgggcatc gttgggggtc aggaggcccc caggagcaag tggccctggc aggtgagcct 121 gagagtccgc gaccgatact ggatgcactt ctgcgggggc tccctcatcc acccccagtg 181 ggtgctgacc gcagcgcact gcgtgggacc ggacgtcaag gatctggccg ccctcagggt 241 gcaactgcgg gagcagcacc tctactacca ggaccagctg ctgccggtca gcaggatcat 301 cgtgcaccca cagttctaca ccgcccagat cggagcggac atcgccctgc tggagctgga 361 ggagccggtg aaggtctcca gccacgtcca cacggtcacc ctgccccctg cctcagagac 421 cttccccccg gggatgccgt gctgggtcac tggctggggc gatgtggaca atgatgagcg 481 cctcccaccg ccatttcctc tgaagcaggt gaaggtcccc ataatggaaa accacatttg 541 tgacgcaaaa taccaccttg gcgcctacac gggagacgac gtccgcatcg tccgtgacga 601 catgctgtgt gccgggaaca cccggaggga ctcatgccag ggcgactccg gagggcccct 661 ggtgtgcaag gtgaatggca cctggctgca ggcgggcgtg gtcagctggg gcgagggctg 721 tgcccagccc aaccggcctg gcatctacac ccgtgtcacc tactacttgg actggatcca 781 ccactatgtc cccaaaaagc cgtgagtcag gcctggggtg tccacctggg tcactggagg 841 accagcccct cctgtccaaa acaccactgc ttcctaccca ggcggcgact gccccccaca 901 ccttccctgc cccgtcctga gtgccccttc ctgtcctaag ccccctgctc tcttctgagc 961 cccttcccct gtcctgagga cccttcccca tcctgagccc ccttccctgt cctaagcctg 1021 acgcctgcac cgggccctcc ggccctcccc tgcccaggca gctggtggtg ggcgctaatc 1081 c

(2) INFORMATION FOR SEQ ID NO: 2650: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2650

1 atctggaagc ataaatgggg aggggagagc ccactgggta gaaggaacag ggagcggcca

61 gggtaagtcc ccactctcag agaccctgac atcagcgtca cctggagcag agtggcccag

121 cttcagactc agagcaccaa gacccaggcc tgcaggcctg gacccacccc ggtccccccg

181 tcccagctcc attcttcacc ccacaatctg tagcccccag ccctgccctg tgaggcccgg

241 ccaggcccac gatgctcctc cttgctcccc agatgctgaa tctgctgctg ctggcgctgc

301 ccgtcctggc gagccgcgcc tacgcggccc ctggtgagtc ccagccgggg tccaccctgc

361 ccctcaccac attccacagg tcagggcctg ggtgggttct ggggaggtcg ggctggcccc

421 cacacaggga agggctgggc ccaggcctgg ggctgcttcc tggtcctgac ctggcacctg

481 ccccagcccc aggccaggcc ctgcagcgag tgggcatcgt tgggggtcag gaggccccca

541 ggagcaagtg gccctggcag gtgagcctga gagtccgcga ccgatactgg atgcacttct

601 gcgggggctc cctcatccac ccccagtggg tgctgaccgc agcgcactgc gtgggaccgt

661 gagtctcccg gggcctggag gggtggggaa gggctggatg tgagccctgg ctcccgggtg

721 ctcctggggg ctgcccaggg ccctgagtgg gatcctccgc tgcccaggga cgtcaaggat

781 ctggccgccc tcagggtgca actgcgggag cagcacctct actaccagga ccagctgctg

841 ccggtcagca ggatcatcgt gcacccacag ttctacaccg cccagatcgg agcggacatc EPI-109 810

901 gccctgctgg agctggagga gccggtgaac gtctccagcc acgtccacac ggtcaccctg 961 ccccctgcct cagagacctt ccccccgggg atgccgtgct gggtcactgg ctggggcgat 1021 gtggacaatg atggtgggtc tggggacagt ggaggtgggg ccagggtctt agccacagcc 1081 cagcccctgg gctccctctg ggctccaggt gggggttgcc cggccccctc ctgaggctgc 1141 accctcttcc ccacctgcag agcgcctccc accgccattt cctctgaagc aggtgaaggt 1201 ccccataatg gaaaaccaca tttgtgacgc aaaataccac cttggcgcct acacgggaga 1261 cgacgtccgc atcgtccgtg acgacatgct gtgtgccggg aacacccgga gggactcatg 1321 ccaggtgggc cccgcctgtc ccccgccccc cgccccccaa cccccactcc caggcctgtt 1381 cggcgagcgc tgacctctga ccttcccagg gcgactccgg agggcccctg gtgtgcaagg 1441 tgaatggcac ctggctgcag gcgggcgtgg tcagctgggg cgagggctgt gcccagccca 1501 accggcctgg catctacacc cgtgtcacct actacttgga ctggatccac cactatgtcc 1561 ccaaaaagcc gtgagtcagg cctggggtgt ccacctgggt cactggagag ccagcccctc 1621 ctgtccaaaa caccactgct tcctacccag gtggcgactg ccccccacac cttccctgcc 1681 ccgtcctgag tgccccttcc tgtcctaagc cccctgctct cttctgagcc ccttcccctg 1741 tcctgaggac ccttccccat cctgagcccc cttccctgtc ctaagcctga cgcctgcacc 1801 gggccctccg gccctcccct gcccaggcag ctggtggtgg gcgctaatcc tcctgagtgc 1861 tggacctcat taaagtgcat ggaaatcact ggtgtgcatc gctgtgtttc tggttgtgga 1921 tgtcactggg agagaagggg tccaggtgtg ctgaggacac ctgccacagt gtgaggtcct 1981 agccctcaag gcacagccag tcaccgtggg acggggcctc ctgggcagcc ctggtccccg 2041 aggctggctt ctccccacac gatgcatcca gcattcgggt cacacagagc cactcgggca 2101 actcagttga ttataaagga cagccaggtc cctgcaaccg ggtcaagaca gaaatggtca 2161 ccgggaaccc cagggctgcc catcacgagc ccctacccca cgcttcccac gagctcttct 2221 cccggccctc ccgtccatgc ttgtgctttg cctaattgtt tgcttttgag aacgggattg

INFORMATION FOR SEQ ID NO: 2651: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2651

1 gggtctcaag gaatctttat tctgcgtctt cattctgaac tggatggaac cttcctgagc 61 gcagagtcct ttccactgtg aattatgggt ttgttatcgt ttttgttcgt tgctggttgt

121 acgtgacggg agttcagctt tttgctgcgg gacggcagag ataggatgcg gggcttcctg

181 agaggcgccg gggcagggcc gcacaggtcc atccacctcc cctgggaccc cagccctgca

241 gcagccccag gggagcggcc ggggatcggg gcggggtgcc caggacgcgc cctgattggc

301 ccagtgttag ccaatcaagg ctctcgcatc cccatggtgc tgattggtcc gcctcccagg

361 cctgacccaa tcggagcatt cctaggagga gcggccccag agcgcctgac tcgggggtcc

421 cagagccctc tgcacaccac agccccggtg tccccgtgtg tccctgggtt ctcccagccc

481 tggtgtcccc tgagtctctt cttcaccgtc agccctggtg tctcccgtgt ccctgccaca

541 ccctcatccc tggtgtcccc cgtcacccca tcccctcacc tcctgggctc ctgaaggtcc

601 catcttgtgg gcctcattca tggaaccagg acggggcagg tggaggcctc tggggagttt

661 gtccagagaa tggaggagaa gcagggtcat gagcaggagc ggtctgggcc acccctgcct

721 gtcccccggg gggtgcagcc cggaaggagt ccagatggat atggccccgc agtgcagagt

781 cagccccaaa ccaggctggt cccaggcagg gtgggggcag gaggagcccc ggagtggccc

841 tgtgttgggg gtcggggggc aggcaggggg tcctggggct cagaagcgga ggaggtgggc

901 tggaggcccc agtgaccaac aggcccacgg gagtcgggag gtggggtgga cggacctgca

961 gggacagtgt cagcgctgaa tgggatggag agcacaggga gctggggccg gggatgagac

1021 catggggagc tggggctggg gctgggacta gtccatgggg agctggggct gaagttgggg

1081 gtgagtccat ggggagctgg gctgggcctc ctggggttgc acctgcactc ctctctgctc

1141 ttccctctgc gtatgaagct cagatcccat gataaggagg cacctgcaga ccaggggacc

1201 tgcacggaca gccccagagg tggacattga ggactcgtag gaggacttgg gtctcatacg

1261 gcgggtgggg agcagggccc cttcctggct gaggacactt ggtgctgtcc cctctcaagg

1321 ctgtttcccc atctgacaaa ggggtctcat gtgagccccc aaccaagtga gtcgaggagg

1381 gctggcccca cccccgtgga tttggagtcc gtaggagggg tgtcacccgt cacgtcccca

1441 ccccgtgggc accttcccgt ctcttggagc gtggcccatg gacatgagtt cctcacccgt

1501 gtccctcttg gggaaacagg tttcaggagc gacgggtctt gtagcctggg gcagccaggc

1561 cacctgggtg cagctatgcc tgaaggcctc ctggcaccga gacaggggca ggagcagatc

1621 ccaccagcgg gaaggtggtg cgttctgatg ctgggatcca ccagctgaca ggtggagctg

1681 cgagcctcca gtgctcagcc ctcggcgggg cctgcctggc agccccacac acagagggca

1741 tcggggtggc gggggcacgt gttacacggg ggccctgggt ctgagtcatc cacttcctcc

1801 gagtctggat gggaggaccc agcgcccctc ctccgccccc tcctgatctg gaaggataaa

1861 tggggagggg agagcccgct gggtagaagg aacagggagt ggccagggta agtccctact

1921 ctcagagacc ctgacatcag tgtcacctgg agcagagtgg cccagcctca gactcagagc

1981 accaagaccc aggcccgcag gcctggaccc accccggtcc ccccgtccca gctccattct

2041 tcaccccaca atctgtagcc cccagccctg ccctgtgagg cccggccagg cccacgatgc

2101 tcctccttgc tccccagatg ctgagcctgc tgctgctggc gctgcccgtc ctggcgagcc

2161 cggcctacgc ggcccctggt gagtcccagc cggggtccac cctgcccctc accacattcc

2221 acaggtcagg gcctgggtgg gttctgggga ggctgggctg gcccccacac agggaagggc EPI-109 811

2281 tgggcccagg cgtggggctg cttcctggtc ctgacctggc acctgcccca gccccagtcc 2341 aggccctgca gcaagcgggt atcgtcgggg gtcaggaggc ccccaggagc aagtggccct 2401 ggcaggtgag cctgagagtc cgcgaccgat actggatgca cttctgtggg ggctccctca 2461 tccaccccca gtgggtgctg accgcggcgc actgcctggg accgtgagtc tcccagggcc 2521 tggaggggtg ggcaagggct ggatgtgagc cctggctccc gggtgctcct gggggctgcc 2581 cagggccctg agtgggatcc tccgctgccc agggacgtca aggatctggc caccctcagg 2641 gtgcaactgc gggagcagca cctctactac caggaccagc tgctgccggt cagcaggatc 2701 atcgtgcacc cacagttcta catcatccag actggagcgg atatcgccct gctggagctg 2761 gaggagcccg tgaacatctc cagccgcgtc cacacggtca tgctgccccc tgcctcggag 2821 accttccccc cggggatgcc gtgctgggtc actggctggg gcgatgtgga caatgatggt 2881 gggtctgggg acagtgggag gtggggccag ggtcttagcc acagcccagc ccctgggctc 2941 caggtggggg ttgcccggcc ccctcctcag gctgcaccct cttccccacc tgcagagccc 3001 ctcccaccgc catttcccct gaagcaggtg aaggtcccca taatggaaaa ccacatttgt 3061 gacgcaaaat accaccttgg cgcctacacg ggagacgacg tccgcatcat ccgtgacgac 3121 atgctgtgtg ccgggaacac ccggagggac tcatgccagg tgggccccgc gtgtcccccg 3181 ccccccgcac cccaaccccc actcccaggc ctgttcggcg agcgctgacc tctgaccttc 3241 ccagggcgac tctggagggc ccctggtgtg caaggtgaat ggcacctggc tacaggcggg 3301 cgtggtcagc tgggacgagg gctgtgccca gcccaaccgg cctggcatct acacccgtgt 3361 cacctactac ttggactgga tccaccacta tgtccccaaa aagccgtgag tcaggcctgg 3421 ggtgtccacc tgggtcactg gagagccagc ccctcctgtc caaaacacca ctgcttccta 3481 cccaggtggc gactgccccc cacaccttcc ctgccccgtc ctgagtgccc cttcctgtcc 3541 taagccccct gctctcttct gagccccttc ccctgtcctg aggacccttc cccatcctga 3601 gcccccttcc ctgtcctaag cctgacgcct gcactgggcc ctccggccct cccctgccca 3661 ggcagctggt ggtgggcgct aatcctcctg agtgctggac ctcattaaag tgcatggaaa 3721 tcactggtgt gcatcgctgt gtttctggtt gtggatgtca ctgggagaga aggggtccag 3781 gtgtgctgag gacacctgcc acagtgcgag gtcctagccc tcaaggcaca gccagtcacc 3841 gtgggacggg gcctcctggg cagccctggt ccccggggct ggcttctccc cacacgatgc 3901 atccagcatt cgggtcacac agagccactc gggcaactca gttgattata aaggacagcc 3961 aagtccctgc aaccgggtca agacagagaa tggtcgccgg gagccccagg gctgcccatc 4021 acgagcccct accccacgct tcccacgagc tcttctcccg gcccctctgt ccactgcttg 4081 tgctttgccc tagttgtttg ctttgagaca ggatctcgct gtgtcatcca ggctgaagtg 4141 cagtggtgtg atcagggctc actgtagcct tgaactcctg ggctcaagcg atcctcccat 4201 cttggcctcc catatagctg ggccacagga gtgagccacc acgcccagtt aatttttgta 4261 ttttcagtag agatggggtt tcgccatgtt ggccagtctg gtctcgaact cctgacctca 4321 agtgatctgc ccgcctcggc ctcccaaagt gctgggatga caggcgtgag ccaccgcacc 4381 cagcctgagt ttgacatttt caaattcatt ttgaggtctt tctctacatc aatacatgag 4441 ccctccgcgt ccggcgagtg ttgcatttta tcccgggctc ttgtttgcat tttatatttg 4501 aacatgatta cattcaggaa tgaaatgcgg ggctgttctg gttgaaaaca actctctaaa 4561 gaaacattca ctctttcctt ccaactgtca gatgcagaga tgtgcattta gtctctccaa 4621 tctctgcaaa tgacctctgt cctcacaagg ggtggactcg acttccagcg ccctctccag 4681 ccccacgtga cctctgcctc tgcagcccct gaaggcccat ccctcggctc ctgttctgca 4741 ggcccagcgt cttgtctatg aagatggacc tggaactcgg gccctccttc ctccctctgg 4801 cccatcccac cttctaggga tcacagagac agcacggggt gacccccagg gaacactgag 4861 cccctagaag cacttccaca cgcccactgg aggttttgcg gggtgggagt cggagggatg 4921 agaccccgaa gggaagcaag acggcccctc aggacagggc tgccggtgta aggaaaggtg 4981 gacagcaggg gccggtcact gggtggaggg ggagggcagg ctccagcccc agagcttccc 5041 aaattagatc taagatccct gggaagctca gtgaagctca gcgcagtgac actggcagat 5101 gtgagcgtca gcttcagcag gaagggtctc tcaggacgtg acaggcaggc tgctggccag 5161 ggctgcagcc acctgcgttt tgactgggac gggggcacct gatccaaggt cacccacgtg 5221 gctgccggca ggaggccctg gttccccgtc acaagggggt gtgaggggga aggccaagtg 5281 gtggccacan ggttnccacc gagagggaca gtgcccaagt tggccaagcc accctnggac 5341 aagaaacaat nccaagtctt nccaaggtcc ttggacaaca aggagaancc cccccagctt 5401 gggggcnatt aaccaagggc cangnccccc cttcccggtt c

1 tggacccacc ccggtccccc cgtcccagct tccattcttc accccacaat ctgtagcccc 61 cagccctgcc ctgtgaggcc cggccaggcc cacgatgctc ctccttgctc cccagatgct 121 gaatctgctg ctgctggcgc tgcccgtcct ggcgagccgc gcctacgcgg cccctggtga 181 gtcccagccg gggtccaccc tgcccctcac cacattccac aggtcagggc ctgggtgggt 241 tctggggagg ccgggctggc ccccacacag ggaagggctg ggcccaggcc tggggctgct 301 tcctggtcct gacctggcac ctgccccagc cccaggccag gccctgcagc gagtgggcat 361 cgttgggggt caggaggccc ccaggagc

1 cagatcggag cggacatcgc cctgctggag ctggaggagc cggtgaaggt ctccagccac 61 gtccacacgg tcaccctgcc ccctgcctca gagaccttcc ccccggggat gccgtgctgg 121 gtcactggct ggggcgatgt ggacaatgat ggtgggtctg gggacagtgg aggtggggcc 181 agggtcttag ccacagccca gcccctgggc tccctctggg ctccaggtgg gggttgcccg 241 gccccctcct gaggctgcac cctcttcccc acctgcagag cgcctcccac cgccatttcc 301 tctgaagcag gtgaaggtcc ccataatgga aaaccacatt tgtgacgcaa aataccacct 361 tggcgcctac acgggagacg acgtccgcat cgtccgtgac gacatgctgt gtgccgggaa 421 cacccggagg gactcatgcc aggtgggccc cgcgtgtccc ccgccccccg caccccaacc EPI-109 812

481 cccactccca ggcctgttcg gcgagcgctg acctctgacc ttcccagggc gactccggag

541 ggcccctggt gtgcaaggtg aatggcacct ggctgcaggc gggcgtggtc agctggggcg

601 agggctgtgc ccagcccaac cggcctggca tctacacccg tgtcacctac tacttggact

661 ggatccacca ctatgtcccc aaaaagccgt gagtcaggcc tgggttggcc acctgggtca

721 ctggaggacc aacccctgct gtccaaaaca ccactgcttc ctacccaggt ggcgactgcc

781 ccccacacct tccctgcccc gtcctgagtg ccccttcctg tcctaagccc cctgctctct

841 tctgagcccc ttcccctgtc ctgaggaccc ttccccatcc tgagccccct tccctgtcct

901 aagcctgacg cctgcactgg gccctccggc cctcccctgc ccaggcagct ggtggtgggc

961 gctaatcctc ctgagtgctg gacctcatta aagtgcatgg aaatcactgg tgtgcatcgc

1021 tgtgtttctg gttgtggatg tcactgggag agaaggggtc caggtgtgct gaggacacct

1081 gccacagtgt gaggtcctag ccctcaaggc acaagccagt caccgtggga cggggcctct

1141 gggcagccct ggtccccgag ctggctt

1 ccaggatgct gaatctgctg ctgctggcgc tgcccgtcct ggcgagccgc gcctacgcgg

61 cccctgcccc aggccaggcc ctgcagcgag tgggcatcgt tgggggtcag gaggccccca

121 ggagcaagtg gccctggcag gtgagcctga gagtccacgg cccatactgg atgcacttct

181 gcgggggctc cctcatccac ccccagtggg tgctgaccgc agcgcactgc gtgggaccgg

241 acgtcaagga tctggccgcc ctcagggtgc aactgcggga gcagcacctc tactaccagg

301 accagctgct gccggtcagc aggatcatcg tgcacccaca gttctacacc gcccagatcg

361 gagcggacat cgccctgctg gagctggagg agccggtgaa ggtctccagc cacgtccaca

421 cggtcaccct gccccctgcc tcagagacct tccccccggg gatgccgtgc tgggtcactg

481 gctggggcga tgtggacaat gatgagcgcc tcccaccgcc atttcctctg aagcaggtga

541 aggtccccat aatggaaaac cacatttgtg acgcaaaata ccaccttggc gcctacacgg

601 gagacgacgt ccgcatcgtc cgtgacgaca tgctgtgtgc cgggaacacc cggagggact

661 catgccaggg cgactccgga gggcccctgg tgtgcaaggt gaatggcacc tggctgcagg

721 cgggcgtggt cagctggggc gagggctgtg cccagcccaa ccggcc ggc atctacaccc

781 gtgtcaccta ctacttggac tggatccacc actatgtccc caaaaagccg tgagtcaggc

841 ctgggtgtgc cacctgggtc actggaggac caacccctgc tgtccaaaac accactgctt

901 cctacccagg tggcgactgc cccccacacc ttccctgccc cgtcctgagt gccccttcct

961 gtcctaagcc ccctgctctc ttctgagccc cttcccctgt cctgaggacc cttccccatc

1021 ctgagccccc ttccctgtcc taagcctgac gcctgcactg ctccggccct cccctgccca

1081 ggcagctggt ggtgggcgct aatcctcctg agtgctggac ctcattaaag tgcatggaaa

1141 tea

1 ggccaggatg ctgaatctgc tgctgctggc gctgcccgtc ctggcgagcc gcgcctacgc

61 ggcccctgcc ccaggccagg ccctgcagcg agtgggcatc gttgggggtc aggaggcccc

121 caggagcaag tggccctggc aggtgagcct gagagtccac ggcccatact ggatgcactt

181 ctgcgggggc tccctcatcc acccccagtg ggtgctgacc gcagcgcact gcgtgggacc

241 ggacgtcaag gatctggccg ccctcagggt gcaactgcgg gagcagcacc tctactacca

301 ggaccagctg ctgccggtca gcaggatcat cgtgcaccca cagttctaca ccgcccagat

361 cggagcggac atcgccctgc tggagctgga ggagccggtg aaggtctcca gccacgtcca

421 cacggtcacc ctgccccctg cctcagagac cttccccccg gggatgccgt gctgggtcac

481 tggctggggc gatgtggaca atgatgagcg cctcccaccg ccatttcctc tgaagcaggt

541 gaaggtcccc ataatggaaa accacatttg tgacgcaaaa taccaccttg gcgcctacac

601 gggagacgac gtccgcatcg tccgtgacga catgctgtgt gccgggaaca cccggaggga

661 ctcatgccag ggcgactccg gagggcccct ggtgtgcaag gtgaatggca cctggctgca

721 ggcgggcgtg gtcagctggg gcgagggctg tgcccagccc aaccggcctg gcatctacac

781 ccgtgtcacc tactacttgg actggatcca ccactatgtc cccaaaaagc cgtgagtcag

841 gcctgggttg gccacctggg tcactggagg accaacccct gctgtccaaa acaccactgc

901 ttcctaccca ggtggcgact gccccccaca ccttccctgc cccgtcctga gtgccccttc

961 ctgtcctaag ccccctgctc tcttctgagc cccttcccct gtcctgagga cccttcccca

1021 tcctgagccc ccttccctgt cctaagcctg acgcctgcac cgggccctcc ggccctcccc

1081 tgcccaggca gctggtggtg ggcgctaatc ctcctgagtg ctggacctca ttaaagtgca

1141 tggaa

1 tgaatctgct gctgctggcg ctgcccgtcc tggcgagccg cgcctacgcg gcccctgccc 61 caggccaggc cctgcagcga gtgggcatcg tcgggggtca ggaggccccc aggagcaagt 121 ggccctggca ggtgagcctg agagtccacg gcccatactg gatgcacttc tgcgggggct 181 ccctcatcca cccccagtgg gtgctgaccg cagcgcactg cgtgggaccg gacgtcaagg 241 atctggccgc cctcagggtg caactgcggg agcagcacct ctactaccag gaccagctgc 301 tgccggtcag caggatcatc gtgcacccac agttctacac cgcccagatc ggagcggaca 361 tcgccctgct ggagctggag gagccggtga acgtctccag ccacgtccac acggtcaccc 421 tgccccctgc ctcagagacc ttccccccgg ggatgccgtg ctgggtcact ggctggggcg 481 atgtggacaa tgatgagcgc ctcccaccgc catttcctct gaagcaggtg aaggtcccca 541 taatggaaaa ccacatttgt gacgcaaaat accaccttgg cgcctacacg ggagacgacg 601 tccgcatcgt ccgtgacgac atgctgtgtg ccgggaacac ccggagggac tcatgccagg 661 gcgactccgg agggcccctg gtgtgcaagg tgaatggcac ctggctgcag gcgggcgtgg 721 tcagctgggg cgagggctgt gcccagccca accggcctgg catctacacc cgtgtcacct 781 actacttgga ctggatccac cactatgtcc ccaaaaagcc gtgagtcagg cctgggttgg 841 ccacctgggt cactggagga ccaacccctg ctgtccaaaa caccactgct tcctacccag 901 gtggcgactg ccccccacac cttccctgcc ccgtcctgag tgccccttcc tgtcctaagc EPI-109 813

961 cccctgctct cttctgagcc ccttcccctg tcctgaggac ccttccctat cctgagcccc

1021 cttccctgtc ctaagcctga cgcctgcacc gggccctcca gccctcccct gcccagatag

1081 ctggtggtgg gcgctaatcc tcctgagtgc tggacctcat taaagtgcat ggaaatc

1 accagctgac aggtggagct gccagtctcc agtgctcagc cctcagcggg gcctgcctgg

61 cagccccaca cacagagggc atcggggtgg cgggggcacg tgttacacgg gggccctggg

121 tctgagtcat ccacttcctc cgagtctgga tgggaggacc cagcgcccct cctccgcccc

181 ctcctgatct ggaaggataa atggggaggg gagagccact gggtagaagg aacagggagt

241 ggccagggta agtccccact ctcagagacc ctgacatcag cgtcacctgg agcagagtgg

301 cccagcctca gactcagagc accaagaccc aggcccgcag gcctggaccc accccggtcc

361 ccccgtccca gctccattct tcaccccaca atctgtagcc cccagccctg ccctgtgagg

421 cccggccagg cccacgatgc tcctccttgc tccccagatg ctgaatctgc tgctgctggc

481 gctgcccgtc ctggcgagcc gcgcctacgc ggcccctggt gagtcccagc cggggtccac

541 cctgcccctc accacattcc acaggtcagg gcctgggtgg gttctgggga ggtcgggctg

601 gccccccaca cagggaaggg ctgggcccag gcctggggct gcttcctggt cctgacctgg

661 cacctgcccc agccccaggc caggccctgc agcgagtggg catcgtcggg ggtcaggagg

721 cccccaggag caagtggccc tggcaggtga gcctgagagt ccacggccca tactggatgc

781 acttctgcgg gggctccctc atccaccccc agtgggtgct gaccgcagcg cactgcgtgg

841 gaccgtgagt ctcccggggc ctggaggggt ggggaagggc tggatgtgag ccctggctcc gθl cgggtgctcc tgggggctg.c ccagggccct gagtgggatc ctccgctgcc cagggacgtc

961 aaggatctgg ccgccctcag ggtgcaactg cgggagcagc acctctacta ccaggaccag

1021 ctgctgccgg tcagcaggat catcgtgcac ccacagttct acaccgccca gatcggagcg

1081 gacatcgccc tgctggagct ggaggagccg gtgaacgtct ccagccacgt ccacacggtc

1141 accctgcccc ctgcctcaga gaccttcccc ccggggatgc cgtgctgggt cactggctgg

1201 ggcgatgtgg acaatgatgg tgggtctggg gacagtggag gtggggccag ggtcttagcc

1261 acagcccagc ccctgggtcc ctctgggctc caggtggggg ttgcccggcc ccctcctgag

1321 gctgcaccct cttccccacc tgcagagcgc ctcccaccgc catttcctct gaagcaggtg

1381 aaggtcccca taatggaaaa ccacatttgt gacgcaaaat accaccttgg cgcctacacg

1441 ggagacgacg tccgcatcgt ccgtgacgac atgctgtgtg ccgggaacac ccggagggac

1501 tcatgccagg tgggccccgc ctgtcccccg ccccccgccc cccaaccccc actcccaggc

1561 ctgttcggcg agcgctgacc tctgaccttc ccagggcgac tccggagggc ccctggtgtg

1621 caaggtgaat ggcacctggc tgcaggcggg cgtggtcagc tggggcgagg gctgtgccca

1681 gcccaaccgg cctggcatct acacccgtgt cacctactac ttggactgga tccaccacta

1741 tgtccccaaa aagccgtgag tcaggcctgg gttggccacc tgggtcactg gaggaccaac

1801 ccctgctgtc caaaacacca ctgcttccta cccaggtggc gactgccccc cacaccttcc

1861 ctgccccgtc ctgagtgccc cttcctgtcc taagccccct gctctcttct gagccccttc

1921 ccctgtcctg aggacccttc cctatcctga gcccccttcc ctgtcctaag cctgacgcct ig81 gcaccgggcc ctccagccct cccctgccca gatagctggt ggtgggcgct aatcctcctg

2041 agtgctggac ctcattaaag tgcatggaaa tcactggtgt gcatcgctgt gtttctggtt

2101 gtggatgtca ctgggagaga aggggtccag gtgtgctgag gacacctgcc acagtgtgag

2161 gtcctagccc tcaaggcaca gccagtcacc gtgggac

1 ggaattccgt ggccaggatg ctgagcctgc tgctgctggc gctgcccgtc ctggcgagcc

61 gcgcctacgc ggcccctgcc ccagtccagg ccctgcagca agcgggtatc gtcgggggtc

121 aggaggcccc caggagcaag tggccctggc aggtgagcct gagagtccgc gaccgatact

181 ggatgcactt ctgcgggggc tccctcatcc acccccagtg ggtgctgacc gcggcgcact

241 gcctgggacc ggacgtcaag gatctggcca ccctcagggt gcaactgcgg gagcagcacc

301 tctactacca ggaccagctg ctgccagtca gcaggatcat cgtgcaccca cagttctaca

361 tcatccagac tggagcggat atcgccctgc tggagctgga ggagcccgtg aacatctcca

421 gccgcgtcca cacggtcatg ctgccccctg cctcggagac cttccccccg gggatgccgt

481 gctgggtcac tggctggggc gatgtggaca atgatgagcc cctcccaccg ccatttcccc

541 tgaagcaggt gaaggtcccc ataatggaaa accacatttg tgacgcaaaa taccaccttg

601 gcgcctacac gggagacgac gtccgcatca tccgtgacga catgctgtgt gccgggaaca

661 gccagaggga ctcctgcaag ggcgactctg gagggcccct ggtgtgcaag gtgaatggca

721 cctggctaca ggcgggcgtg gtcagctggg acgagggctg tgcccagccc aaccggcctg

781 gcatctacac ccgtgtcacc tactacttgg actggatcca ccactatgtc cccaaaaagc

841 cgtgagtcag gcctgggtgt gccacctggg tcactggagg accaacccct gctgtccaaa

901 acaccactgc ttcctaccca ggtggcgact gccccccaca ccttccctgc cccgtcctga

961 gtgccccttc ctgtcctaag ccccctgctc tcttctgagc cccttcccct gtcctgagga

1021 cccttcccca tcctgagccc ccttccctgt cctaagcctg acgcctgcac tgctccggcc

1081 ctcccctgcc caggcagctg gtggtgggcg ctaatcctcc tgagtgctgg acctcattaa

1141 ^■ agtgcatgga aatc

1 gctgcccgtc ctggcgagcc gcgcctacgc ggcccctgcc ccaggccagg ccctgcagcg

61 agtgggcatc gttgggggtc aggaggcccc caggagcaag tggccctggc aggtgagcct

121 gagagtccgc gaccgatact ggatgcactt ctgcgggggc tccctcatcc acccccagtg

181 ggtgctgacc gcagcgcact gcgtgggacc ggacgtcaag gatctggccg ccctcagggt

241 gcaactgcgg gagcagcacc tctactacca ggaccagctg ctgccggtca gcaggatcat

301 cgtgcaccca cagttctaca ccgcccagat cggagcggac atcgccctgc tggagctgga

361 ggagccggtg aaggtctcca gccacgtcca cacggtcacc ctgccccctg cctcagagac

421 cttccccccg gggatgccgt gctgggtcac tggctggggc gatgtggaca atgatgagcg EPI-109 814

481 cctcccaccg ccatttcctc tgaagcaggt gaaggtcccc ataatggaaa accacatttg 541 tgacgcaaaa taccaccttg gcgcctacac gggagacgac gtccgcatcg tccgtgacga 601 catgctgtgt gccgggaaca cccggaggga ctcatgccag ggcgactccg gagggcccct 661 ggtgtgcaag gtgaatggca cctggctgca ggcgggcgtg gtcagctggg gcgagggctg 721 tgcccagccc aaccggcctg gcatctacac ccgtgtcacc tactacttgg actggatcca 781 ccactatgtc cccaaaaagc cgtgagtcag gcctggggtg tccacctggg tcactggagg 841 accagcccct cctgtccaaa acaccactgc ttcctaccca ggcggcgact gccccccaca 901 ccttccctgc cccgtcctga gtgccccttc ctgtcctaag ccccctgctc tcttctgagc 961 cccttcccct gtcctgagga cccttcccca tcctgagccc ccttccctgt cctaagcctg 1021 acgcctgcac cgggccctcc ggccctcccc tgcccaggca gctggtggtg ggcgctaatc 1081 c

1 atctggaagc ataaatgggg aggggagagc ccactgggta gaaggaacag ggagcggcca

61 gggtaagtcc ccactctcag agaccctgac atcagcgtca cctggagcag agtggcccag

121 cttcagactc agagcaccaa gacccaggcc tgcaggcctg gacccacccc ggtccccccg

181 tcccagctcc attcttcacc ccacaatctg tagcccccag ccctgccctg tgaggcccgg

241 ccaggcccac gatgctcctc cttgctcccc agatgctgaa tctgctgctg ctggcgctgc

301 ccgtcctggc gagccgcgcc tacgcggccc ctggtgagtc ccagccgggg tccaccctgc

361 ccctcaccac attccacagg tcagggcctg ggtgggttct ggggaggtcg ggctggcccc

421 cacacaggga agggctgggc ccaggcctgg ggctgcttcc tggtcctgac ctggcacctg

481 ccccagcccc aggccaggcc ctgcagcgag tgggcatcgt tgggggtcag gaggccccca

541 ggagcaagtg gccctggcag gtgagcctga gagtccgcga ccgatactgg atgcacttct

601 gcgggggctc cctcatccac ccccagtggg tgctgaccgc agcgcactgc gtgggaccgt

661 gagtctcccg gggcctggag gggtggggaa gggctggatg tgagccctgg ctcccgggtg

721 ctcctggggg ctgcccaggg ccctgagtgg gatcctccgc tgcccaggga cgtcaaggat

781 ctggccgccc tcagggtgca actgcgggag cagcacctct actaccagga ccagctgctg

841 ccggtcagca ggatcatcgt gcacccacag ttctacaccg cccagatcgg agcggacatc

901 gccctgctgg agctggagga gccggtgaac gtctccagcc acgtccacac ggtcaccctg

961 ccccctgcct cagagacctt ccccccgggg atgccgtgct gggtcactgg ctggggcgat

1021 gtggacaatg atggtgggtc tggggacagt ggaggtgggg ccagggtctt agccacagcc

1081 cagcccctgg gctccctctg ggctccaggt gggggttgcc cggccccctc ctgaggctgc

1141 accctcttcc ccacctgcag agcgcctccc accgccattt cctctgaagc aggtgaaggt

1201 ccccataatg gaaaaccaca tttgtgacgc aaaataccac cttggcgcct acacgggaga

1261 cgacgtccgc atcgtccgtg acgacatgct gtgtgccggg aacacccgga gggactcatg

1321 ccaggtgggc cccgcctgtc ccccgccccc cgccccccaa cccccactcc caggcctgtt

1381 cggcgagcgc tgacctctga ccttcccagg gcgactccgg agggcccctg gtgtgcaagg

1441 tgaatggcac ctggctgcag gcgggcgtgg tcagctgggg cgagggctgt gcccagccca

1501 accggcctgg catctacacc cgtgtcacct actacttgga ctggatccac cactatgtcc

1561 ccaaaaagcc gtgagtcagg cctggggtgt ccacctgggt cactggagag ccagcccctc

1621 ctgtccaaaa caccactgct tcctacccag gtggcgactg ccccccacac cttccctgcc

1681 ccgtcctgag tgccccttcc tgtcctaagc cccctgctct cttctgagcc ccttcccctg

1741 tcctgaggac ccttccccat cctgagcccc cttccctgtc ctaagcctga cgcctgcacc

1801 gggccctccg gccctcccct gcccaggcag ctggtggtgg gcgctaatcc tcctgagtgc

1861 tggacctcat taaagtgcat ggaaatcact ggtgtgcatc gctgtgtttc tggttgtgga

1921 tgtcactggg agagaagggg tccaggtgtg ctgaggacac ctgccacagt gtgaggtcct

1981 agccctcaag gcacagccag tcaccgtggg acggggcctc ctgggcagcc ctggtccccg

2041 aggctggctt ctccccacac gatgcatcca gcattcgggt cacacagagc cactcgggca

2101 actcagttga ttataaagga cagccaggtc cctgcaaccg ggtcaagaca gaaatggtca

2161 ccgggaaccc cagggctgcc catcacgagc ccctacccca cgcttcccac gagctcttct

2221 cccggccctc ccgtccatgc ttgtgctttg cctaattgtt tgcttttgag aacgggattg

(2) INFORMATION FOR SEQ ID NO: 2652: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2652

1 ttctccttct ccccaacagt tccccaggga cctctctcta atcagccctc tggcccaggc 61 agtcagatca tcttctcgaa ccccgagtga caagcctgta gcccatgttg tagcaaaccc 121 tcaagctgag gggcagctcc agtggctgaa ccgccgggcc aatgccctcc tggccaatgg 181 cgtggagctg agagataacc agctggtggt gccatcagag ggcctgtacc tcatctactc 241 ccaggtcctc ttcaagggcc aaggctgccc ctccacccat gtgctcctca cccacaccat 301 cagccgcatc gccgtctcct accagaccaa ggtcaacctc ctctctgcca tcaagagccc 361 ctgccagagg gagaccccag agggggctga ggccaagccc tggtatgagc ccatctatct 421 gggaggggtc ttccagctgg agaagggtga ccgactcagc gctgagatca atcggcccga 481 ctatctcgac tttgccgagt ctgggcaggt ctactttggg atcattgccc tgtgaggagg 541 acgaacatcc aaccttccca aacgcctccc ctgccccaat ccctttatta ccccctcctt 601 cagacaccct caacctcttc tggctcaaaa agagaattgg gggcttaggg tcggaaccca EPI-109 815

661 agcttagaac tttaagcaac aagaccacca cttcgaaacc tgggattcag gaatgtgtgg

721 cctgcacagt gaattgctgg caaccactaa gaattcaaac tggggcctcc agaactcact

781 ggggcctaca gctttgatcc ctgacatctg gaatctggag accagggagc ctttggttct

841 ggccagaatg ctgcaggact tgagaagacc tcacctagaa attgacacaa gtggacctta

901 ggccttcctc tctccagatg tttccagact tccttgagac acggagccca gccctcccca

961 tggagccagc tccctctatt tatgtttgca cttgtgatta tttattattt atttattatt

1021 tatttattta cagatgaatg tatttatttg ggagaccggg gtatcctggg ggacccaatg

1081 taggagctgc cttggctcag acatgttttc cgtgaaaacg gagctgaaca ataggctgtt

1141 cccatgtagc cccctggcct ctgtgccttc ttttgattat gttttttaaa atatttatct

1201 gattaagttg tctaaacaat gctgatttgg tgaccaactg tcactcattg ctgagcctct

1261 gctccccagg ggagttgtgt ctgtaatcgc cctactattc agtggcgaga aataaagttt

1321 gctt

(2) INFORMATION FOR SEQ ID NO: 2653: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2653

1 tacgggccgg gcactcccga gctgctgctc gagggcgccg agacggtgac tccagtgctg

61 gacccggcca ggagacaagg gtacgggcct ctctggtaca cgagcgtggg gttcggcggc

121 ctggtgcagc tccggagggg cgagagggtg tacgtcaaca tcagtcaccc cgatatggtg

181 gacttcgcga gagggaagac cttctttggg gccgtgatgg tggggtgagg gaatatgagt

241 gcgtggtgcg agtgcgtgaa tattgggggn ccggacgccc aggaccccat ggcagtggga

301 aaaatgtagg agactgtttg gaaattgatt ttgaacctga tgaaaataaa gaatggaaag

361 cttcagtgct gccgataaag atgctgagtt gcgacacacg tcttaattca gggtgggtgc

421 acgggtgcgg gttaaatatt ctcagtactc ttctggttgc ttgaaacaat tcatcacaac

481 acagtgtatg gcctttgctc ctagggatga tggtctgcct gtcccacccc ctccctgcct

541 ctgaatggcc aggccccacc attagcccag ttggagggtg ggaggaaggg ggacttctca

601 aactccgaag cttctctagg catcctgatt ttcagggcca catggtccca accagactct

661 gcaccatact cttttctctt gggtaccccc caacagtgag aggggtcatt acagagccca

721 gcaagcacca ctcagaaagg cccagcagca gagtaagccc ctatcatgac agaggaatga

781 agcctggagg ggccccgcac ttctccccct agagctgcct gaaggcctct ctgtctccta

841 cccgacagtc aactcttctc ctccaaggag cttaattcaa ggctcatggg gtctgaaggg

901 aggaggctga aggagaaaga aggggagaat attagagaga gatggggatg gcaggaagga

961 gcctgtggtg cctgaaaaca ccaggaagtt ctggggagga ggaaaaaccg atgccccact

1021 tagggtgtcc catttagggt gagacggaaa atcctcacct ttttttcaca ctttaggtcc

1081 cccttcccaa aagtgagtaa gtgtgggtgc ttctgggatg agtaacagtg tcccccatta

1141 cttcatggct gactttcagc cacaggctgg aggaggcaga gggtgaccca aggccctatc

1201 taggtcaccc caatgggtca ccctaccccc tcagcctacc acatggtttt ctcctgcctg

1261 gcaccccagg gctggaggta aagcctaatt ttccgaactt cagttggggc tcccagtcta

1321 ggggggctca atttccgtct ccatattttg ttttggaatt attatttttt tgagacaggg

1381 tctcgttctg tcacccagac gggggtacag tggcatgatc atagcttact gtaacctcaa

1441 actcctgggc ttgagtgatc ctcctgcctc agcctcctga ggagctagga ttacaggcat

1501 gcaccactac acctgactaa tctttaattt tttttctaga aacaaggtct tgctatgttg

1561 cacaggctgg tcttgaacta gtgggctcaa gtggtcctcc cacctcagcc tcccaaagtg

1621 ttgggataac aggcatgagc cactgcgccc cacccttatt tgtctttgac tctctccaga

1681 agagccttca tccagggagg gggtgctttt ctctttccgg attacccacc tctcacctct

1741 cccctccttc accacaaaga ccagtgggac caagccggca tgtgagtcct tcacccacat

1801 cttattccta tgtttcattc ttttttaaaa aatagagaca ggatctcact atgttgccca

1861 ggttgctctg gaactcctgg gttcaagcga tcctctcacc ttggccttgc aaagtggtag

1921 gattacaggt gcatgccacc acgtccggca gttcggttcc ttgttcttta ttgtcctcag

1981 tctcttcgat ttcacccact gagagaatgg aaggggatag aacagctgga aactggttga

2041 aggaagccag aattcactaa gtgcccactg tgccaagggc tgagtgaggt cctctgatgg

2101 aggtcaggcc ttctctcaca tgccctatgt gtggtggaca ttcctatccc cattggatag

2161 ataggttaag tggctggttc aggttgcaga gttaggacag ggtgatttga agcctagaca

2221 cccgaatctc tggaagtccc ttggctgtgt gattcaggta cctgagaatg cggctcctct

2281 ccagctctct ccggactgct ggccagctgc aacagccgga aatctcacct gagctgcagg

2341 attttcccag caaggattgg aattcccaga gttggaaatt cccatgccct gagggagagg

2401 taattaggtt caggctcttg tttcctgggg gatggggaat attctgttgg gctttgttta

2461 tgtagggtct ccagggccct aggagtctaa ggatgggact gggtccgagg gatcttaaag

2521 cctgtggaga gaggacttag ggagcttctt cccacccaca agaagaggca gatgcagaat

2581 taattccaag aaggagacca tgtttctttt ctaagcaaac tttatttctc gccactgaat

2641 agtagggcga ttacagacac aactccctgg ggagcagagg cctcagcaat gagtgacagt

2701 tggtcaccaa atcagcattg tttagacaac ttaatcagat aatattttaa aaaacataat

2761 caaaagaagg cacagaggcc agggggctac atgggaacag cctattgttc agcctccgtt

2821 ttcacggaaa acatgtctga gccaaggcag ctcctacatt gggtccccca ggataccccg

2881 gtctcccaaa taaatacatt catctgtaaa taaataaata ataaataaat aataaataat EPI-109 816

2941 cacaagtgca aacataaata gagggagctg gctccatggg gagggctggg ctccgtgtct 3001 caaggaagtc tggaaacatc tggagagagg aaggcctaag gtccacttgt gtcaatttct 3061 aggtgaggtc ttctcaagtc ctgcagcatt ctggccagaa ccaaaggctc cctggtctcc 3121 agattccaga tgtcagggat caaagctgta ggccccagtg agttctggag gccccagttt 3181 gaattcttag tggttgccag cacttcactg tgcaggccac acattcctga atcccaggtt 3241 tcgaagtggt ggtcttgttg cttaaagttc taagcttggg ttccgaccct aagcccccaa 3301 ttctcttttt gagccagaag aggttgaggg tgtctgaagg agggggtaat aaagggattg 3361 gggcagggga ggcgtttggg aaggttggat gttcgtcctc ctcacagggc aatgatccca 3421 aagtagacct gcccagactc ggcaaagtcg agatagtcgg gccgattgat ctcagcgctg 3481 agtcggtcac ccttctccag ctggaagacc cctcccagat agatgggctc ataccagggc 3541 ttggcctcag ccccctctgg ggtctccctc tggcaggggc tcttgatggc agagaggagg

3601 ttgaccttgg tctggtagga gacggcgatg cggctgatgg tgtgggtgag gagcacatgg 3661 gtggaggggc agccttggcc cttgaagagg acctgggagt agatgaggta caggccctct 3721 gatggcacca ccagctggtt atctctcagc tccacgccat tggccaggag ggcattggcc 3781 cggcggttca gccactggag ctgcccctca gcttgagggt ttgctggagg gagggagaga 3841 gggagaggag agtcagtgtg gccatgtcgg ttcactctcc acatcctggc cctcgagctc 3901 tgcccacccc acatccggtt cctgtcctct ctgtctgtca tcccacatcc cacctggcca 3961 tgacgttctg agtatcccac taaggcctgt gctgttcctc cacccttccc ttgagctcag 4021 cgagtccttc tcacattgtc tccaagttct gcctaccatc agccgggctt caatccccaa 4081 atcctagccc tccaagttcc aagacacatc ctcagagctc ttacctacaa catgggctac 4141 aggcttgtca ctcggggttc gagaagatga tcctgaagag gagagagaaa agaaaaagct 4201 gagaccctta aacttcctag aaaatacccc cctactttca cctccatcca tcctccccca 4261 agaccaaaac tttaaatttc ccccactgct ttccataccg gtactaaccc taccccccaa 4321 acccaaaccc agaattagga aagaggtttg gagacactta ctgactgcct gggccagagg 4381 gctgattaga gagaggtccc tggggaactg ttggggagaa ggagaatggt taacatcgag 4441 ggagtcaccc ttaaaggagg aacagctggc tgcctgtctg gcctgcgctc ttagccctga 4501 ggtgtctggt tttctctctc cattcatctg tgtattcacc ttccaggcat tcaacagctc 4561 tttccctgag tgtcttctgt gtgccagaca ccctatcttc ttctctcctt atctccccca 4621 tctctctcct tagctgtcat atttcccgct ctttctgtct caccatcttt attcatatca 4681 cttgtttctt cccccatctc tcttctcaca ccccacatct gtctccatat cttatttata 4741 tatctgcttg ttcattcatt cattcattca ttcactccat acacacttag tgagcacctt 4801 ccatgtgcca gacatcctgt ctctccatct ttctctctct ctcttcccca tctcttgcca 4861 catctctttc tgcatccccg tctttctcca cgtttttttc tctccatccc tccctatcag

4921 cgcacatctt tcacccatcc catctctctc cctctcttgc gtctccattt ccccttgggt 4981 gggagagtgg atgaaggctg gccaggcact cacctcttcc ctctgggggc cgatcactcc 5041 aaagtgcagc aggcagaaga gcgtggtggc gcctgccacg atcaggaagg agaagaggct 5101 gaggaacaag caccgcctgg agccctgggg cccccctgtc ttcttgggga gcgcctcctc 5161 ggccagctcc acgtcccgga tcatgctttc agtgctcatg gtgtcctttc caggggagag 5221 agggtggagc cgtgggtcag tatgtgagag gaagagaacc tgcctggcag cttgtcaggg 5281 gatgtggcgt ctgagggttg ttttcagggg gggtctgtag ttgcttctct ccctcttagc 5341 tggtcctctg ctgtccttgc tgagggagcg tctgctggct gggtgtgcca acaactgcct 5401 ttatatgtcc ctggggcgag aggagggcgg ggaaagaatc attcaaccag cggaaaactt 5461 ccttggtgga gaaacccatg agctcatctg gaggaagcgg tagtgggccc tgcaccttct 5521 gtctcggttt cttctccatc gcgggggcgg ggatttggaa agttggggac acacaagcat 5581 caaggatacc cctcacactc cccatcctcc ctgctccgat tccgaggggg gtcttctggg 5641 ccactgactg atttgtgtgt aggaccctgg aggctgaacc ccgtccccat gcccctcaaa 5701 acctattgcc tccatttctt ttggggacca ggtctgtggt ctgtttcctt ctaacttcca 5761 gacaggatgc aggaaaaaga tagaactaga actgggaggg gcttcagaaa gctgagtccg 5821 ttgagggaga gaaaacgggg ttggagggaa aagctgtgtt gagtcctgag gcctgtgttt 5881 gggccctgcg gggagaagga gctgggggct tggtggcagg cttgaggcct caggaaaggc 5941 tgggtgcggg tagcagggac aagcctggga cagccccggg gagtgaaatc acccccggga 6001 attcacagac cccactgggg caggccctct tctttcattc tgacccggag actcataatg 6061 cttggttcag tcttggcttc caaggaactc tggggtccct gatttttttc atgaagctct 6121 cacttctcag ggccccagtg tgtggccata tcttcttaaa cgtcccctgt attccatacc 6181 tggaggtcct ggaggctctt tcactccctg gggccctcta catggccctg tcttcgttaa 6241 gtgggggtcc ccatactcga cttccatagc cctggacatt ctcctaccca ttgctgtggt 6301 cacatctccc cagaggtctc ctgtaaccca ttcctcagag ccgctacatg tggccatatc 6361 tcccaggagc tccctgaccc ccgcccctcc agaccctgac ttttccttcg tcttctcagc 6421 ttctcctttg cttcccctgc agcagtctgg cggcctcacc tggtgagtcc atcacatatc 6481 cctgaagctc tctgagccct tatccttttg ttctccccac agctcttgct ccctttgagc 6541 cctctgtccc tccctccatt ccttagatag actgggaagt tctcactccc agacacacac 6601 acacaagcag acagcatttc agagaaaaga ggtttattgg gcttcatcga gggtgcagat 6661 gcctccgtgt ggggctctgg tcggcagctg gctttcagag cctttccctg ccttctgggg 6721 ccctgtgatc cctcatgcct acttctttct ctcttggtca gccttgtgcg catgccctct 6781 cactcttcat ctcttgggcc tgtctctgtt tctccttgga tgttcttcta ttattcccct 6841 ctctccatcc tccataaata aataatttaa tttttttgcc ttcataaata gtcccctccc 6901 tgcctctagt catcccccaa gctcctccat gtgcctgctc ttcctctgtg tgtggatcta 6961 ggccccacct agctggtggg acagaccaac agctttgggc tgggaattcc taggcaggct EPI-109 817

7021 tgaaatcctc agccagacag acatcaggga tggttcaggg aggtgtggtc ccctgggatg 7081 cctagaattc cttctttgaa agctccggtg acttgatcag ggaagacttg agctgttgga 7141 atggccaaag gagaggtggt gacgacccct gaaatggtca gaatggaggc agaatgggga 7201 gaaggtcttg aaatcaatta ttttttcttt ctggattttt ccaagttcta cagagcgaag 7261 gctccaaaga agacagtact agggctgagg actaggtggg ggatgccatc tgtgtgggtg 7321 gatagctggt ctccctgggt gagctggaac gcagccccgt ggtacatcga gtgcagccag 7381 ggttcctgca gccctggata caccatcttc tgggagctga ggagaggcac atggaagggg 7441 tactgggagg agaagagctg gacctcatgg gccaggtaga gtggggagga ggtggccttg 7501 ggagagtagg ctttcccaga gaagaccacc tgggagtaga cgaagtagat gccactggtg 7561 gggaccagga gagaattgtt gctcaaggag aaaccatcct ggaggaaggc acggtccgtg 7621 tttgctctcc agagcagtga gttctgcttg ctggggtctc ctaggaagag ccatagggga 7681 tgggggtggg agatcagggg tctggatcag aggtctcaat ccctgaggaa gtgggcactg 7741 aacaactgag ttcctggggg atggcagggg gaggcatagg agtgggctcc ctctgttttt 7801 tttagcgtgg gggaagttgg gggagagggg tggatgcttg ggttcctgag gcaggggtag 7861 gaggagagct ggtggggaca tgtctgggag gtcaggtgga tgtttaccaa tgaggtgagc 7921 agcaggtttg agggtgctgt gggcaagatg catcttgggg tgctgacggg cagtctgggc 7981 agctgaaggt gtgaggccaa caccagggag cccctagggg agaacagagt tgaggggggc 8041 tctagggctc aaggtttggc tgagccaccc cagcagcccc cattctcctg ctgcctcacc 8101 tgggccccag gcagcagaac cagcagcagc cccagaagga ggaggtgtag ggtggtgcca 8161 cgcacccttg ggaggaagag acgttcaggt ggtgtcatgg ggagaacctg cagagaaaga 8221 gagagagaga gagagacagt gagcggggcg gggcacgcgg cggaagacag acctcccgcc 8281 ctgggagaca gcaccccccg acccccgaga gagagatcga cagagaaggg gacaagatgc 8341 agtcagagaa accccaaggt gagcagaggg agacagagag agacaggaag ggaacagaga 8401 ggaatcatgg cagaaacaga gaatgtgtga cagagacaat gagactgaca gatggagagt 8461 cagagacaga gaaggaaacc aaaaccaaac ccaccaaggc ccaggcccag gcaggccggg 8521 gatccaggca gcaggtgcag gagggaccga ggcccaggca gagggcagga cactgcgggg 8581 cggtagtcca aagcacgaag cacgggcagc ccaaggagat ggggcaggag agcctcacct 8641 gctgtgcgga cccctgggcc cggacgctca ggtcccttta tagaggaagc ggcagtggca 8701 gcgtggcagg cagcgggcgg gttctaggtc ggggctgggg cccggggaag cccccagggc 8761 ttagaagata ctgctgtttc agtcaaaggc aggaaaggct gaggcctagg agagaaccac 8821 aggctggggg ttcaggcgac tgagttctgg gaaagggagt cgggtcaggg gaatcgtggg 8881 ctgggagggc cagggagtgg ggtcaggcct agagttccaa agaagggaca gtcaattcag 8941 agaggaggca gttgagcagc tggggtgtga gctggaggcc cggttccctg aagagcaatc 9001 atatataaca tctctgcacc cttggctgag tacaggcttc tctctttgcc catttccttc 9061 tcttgtaccc ctgtccttgt cccaaacaac tcaaatcata cttgtcccag tatacggact 9121 ttccagccca tctggcaggt ttcacatcaa gaaggtccat tatatatccc cttcatcggg 9181 gacattctgg tgtttgcctc ttgtccaggt gaaaatatta atggatcccc cttccactct 9241 tgaaagtgtc ctagtttgga agataaattt tttggtcccc ttactcagag atgatgctgg 9301 acagtcaagt atgatgaggt ctcatctcac tcctgaagga tgccctccat ctcttcctga 9361 cttcaggtgg cttccacaga acagatttat ataaccccaa ataaacacac attccaggat 9421 caatgtggca gacaccttcc aaagttttct acaaaggaag tttgcagaat tccacatggg 9481 tgaggcttaa gggtggtgac ttagggtggg gtggggacag ctaagggact tgttctgaag 9541 ctgcatttgc agagccaata cattatttta aaattgttcc aggcctggtg cagtggctca 9601 cacctgtaat cctggcactt tgggagtctg aggtgggcgg attacttgag gtcaggagtt 9661 tgagaccagc tggccaacat ggtgaaaccc catctctata ataaatacaa aaattagcca 9721 ggcgtgctgg tgcgcatctg cagtcccagc tactcgggag gctgaggctg gagaattatt 9781 tgaacctggg aggcggaggc tgcagtgagt caagatcgca ccactgtatt ccagcctggg 9841 ggacagagca agactctgtc tcaaaaaaaa aaaaaaagtt tccaaaattt ttttcctttt

9goι tattgatatg taacttaggt atgaggtgga cacctcttaa gtgtacagct gatgaatttt

9961 tccatctgta tgtagccacc acccagctcc acgtattttc aggtccccag caggttccct 10021 catgccccct ccctgctgat accctccaaa gataaccaac cactctctca cttttatcac 10081 catagattat ttcctcctgg tttggggcat catataaatg aaatcacaca gaatgtactc 10141 atttctgttt gacttctttc agtcagcatt atgtttgtga gattcatata cgtggttgta 10201 tgtatcagta atgtttttta aaaaaattat gatgtaatat tctattgtat caatatattc 10261 taatatattc tgttgatggg gatttggttt gtttctagtt tttgtctaac acaaaaatgt 10321 ctacacgaac attctcatac atgagcccat ttcacttagc ttgcaagtta caaggtttaa 10381 aaaaagcagt ttctaaagat gactttattc acttttccta agtttgagat aataccaact 10441 tgtcacctca aatattatta ctgctactca tgtgatttta cttggagagt gttagagggg 10501 ttggagctgg ggctggtggt gacccggggt aaagcccact gttgcatggg gcagaccact 10561 tctctcccca ggcacaaggt ccctgagggg tcttggtgta acatggaggg acatgtaagt 10621 aacattctgg gtgtgtatga gctatttctc ctgttcttct ctacttgagg acctgcccct 10681 ttgcctttta tgctttacta gtcttagcta ttatttctgt aggggcagaa aggggtgatc 10741 ccttcctgac ccatcataag ggttatggcc aatactccta taataaaaga cagattaaca 10801 agagaaaagc ataatacatt tatttaatca aagttttagg tgacatggga gccttcagaa 10861 atgaagaccc aaggacccag gggaaaacta tttttatgct tagatttgat gaagaatgaa 10921 cagctgtgca gaaatgtaat tgaacaaaag gagtatcatc taatggtcac agactgggac 10981 tggggggatc ccagcaaggc ctggccatat tcttcttggt ctctctgtac agcattcctt 11041 cctcccaggt atagggcaga acctcttctg gaatgagggt cttataacct actatcagat EPI-109 818

11101 gagataagtc agaaaatttc ttttcctttt tttttttttg agacagtttc tcactgtcgc

11161 acaggctgga gtgcagtggc acgatcttgg ctcactgcaa cctctgcctc ccaggttcaa

11221 gctattctcc tgcctcagcc tcccgagtag ctgggattac aggcacacgc caccaagccc

11281 gccaaatttt tttttgtatt tttagtagag acggggtctc accatgttgg ccaggttggt

11341 cttgaattcc tgaccacagg tgacccacca gccttggcct cccaaagtgc tgggattatg

11401 ggcgtgagcc actgcgccca accttcttct cattctttta accttattat ctcttgtgtc

11461 agtgtgggtt tcccttttag cccctgctcc tttctttttc tctgtgttgc cctttctctc

11521 agggtccttt ttgcttcctg ttgtctcttt ctgcttctct aatggtatga gctgatggac

11581 tgggacccca gctgagctat attaaaatat aaaatgttat tacaaggcca ggagcagtgg

11641 cacatgcctg tcatcccagc actttgggag gctgaggcga gcagatcaca aggtcaggag

11701 atagagacaa tcctggctaa tacggtgaaa ctccatcact gctaaaaata caaaaaatta

11761 gccgagcatg gtggcacgcg cctgtaatcc tagctactag ggaagctgag gcaggagaac

11821 tgcttgaacc caggaggcgg aggttgcagt gagccgagat cgtgccactg ccctccagcc

11881 tgggcaacaa agtgagactc catttcaaac aaaccaacca aaaaacaaaa caaaacaaaa

11941 caagcaaaca aaaaaaggta ttgcaattaa cagtgagaca cagagagaaa tttaaattaa

12001 agaggaagaa tgggacattg aaagacaaaa aagggaaggc aagaagggtg atggggagac

12061 atgagagaca cagaggaagg aagggtaaga ctgggctgag gctcagtgtc acgtgcatgt

12121 gagatatgcg aaggatgctc cttgagatgg gccaatcttg gtttcaatct cagtttcgga

12181 ggttgtatga atttggtttc tttcttggca ggccagcagt tggtttggga ctttccctgg

12241 gtgggagagc tgatgactgg agtcttgtgc cccagactca gggaaataca gtctttatag

12301 tggtctttgt ggagaaacta gtgaaatctc tgaagcctcc aaatgagact gaaatgacat

12361 tagcttcaaa cttgaactta gcctcaaaac ctgaattggg atttaatacc aacatcaacc

12421 ctaacccaaa tttaacctca acccaaatca caactcaaac tcaaccccaa ctgtaaccct

12481 aacctcaaat ctaaacacat cccaattaat aaccccctaa ataaaacttc tcctctaccc

12541 caacccaacc ctgtttctag ggctaatctt gaaaccagtt taccaccact cctaacacta

12601 aacttaaatc tgactctaaa tgtaagtcca atctgagcca caagcctaaa gttgaacttt

12661 atcctgcttt atgaattatt catccattcc tccatttagt gagtatctgc gtgcctaaca

12721 catgctgggc attgtcctaa ggcaggaggg acatggaggg caaagggatc agagaaggta

12781 ccagcacctg tggagcttgt attccagtga ggcccagacg gaaaaagaaa gaaacttgaa

12841 ggaaggaaat ttggtactat gagaaaataa gacaggctga tgttgtaaga gtggcaggga

12901 gctactttta aatacagtag tcagcaaaat cctctttgag tgtttgggtg gcactggagc

12961 tgagacccaa atgacaaaaa atagtgacca ggtaaaagtt tgggagcaaa gcatttcagg

13021 taaagggagc agctactgca aaggctggaa ggcggaacca agctgggggt gttgacgaca

13081 aacagaaggc cagtgtggct ggagcagaga gagagactgg gaggcgggtg ggagatgagg

13141 tcagagagga gggcaggggc caggtcatgc agggccatgc aagaagggta aagcctctag

13201 atttcatcca gccacaggaa gcctttaaag gtcgtcagag tgtgtggtgc gtgcgtgtgt

13261 gtgtgtgtgt gtgtgttgca ggggagagag gnggagggag agagagagag agagaagagg

13321 gaggtgagca gaggtgattg gatttttttt tcttttgaca tggtgtcttg ctctgtggcc

13381 taggctggag tgcagtggca ccatcatagc ccactgcaac ctcaaaacca tgggctcaag

13441 tcatccttcc acctcagctt cccaagtatc taggactaca ggtgtgtgcc actgtgcctg

13501 gctaatttta aaaaatattt taaaattttt gttgagacag ggtctatgct gctcaggctg

13561 gtctcgaact cctggtttca agtgatctgc ccatcttggc ctcccaaagt ttttttttgt

13621 tagtttgaga ggcggtttcg ctcgttgccc aggctggagt gcaatgactg atctcatctc

13681 actgcaacct ctgcctcctg ggttcaagcg attctcctgc ttcagcctcc caagtagctg

13741 ggattacagg tgcatgccac cattcccggc taattttttg tatttagtag agatggggtt

13801 caccatgtta gtcaggctga tctcaaactc ctgacctcag gtgatccgcc tgcctcagcc

13861 tcccaaagtt ttgggattac aggtgtgagc caccatgctg ggccagcctc ccaaagtttt

13921 gggattacag gcatgagtca ccacactggc cctggatttt ttttctttct tttttttgga

13981 gacggagtct cactctgttg cccaggctgg agtgcaatgg cgtaatctca gctcactgca

14041 acctctgctg cccgggttca aacgattctc ctgtcttagc ctcctgagta gctgggatta

14101 taggtgcatg ccaccatgcc tggctaattt ttgtactttt agtagagaaa gtacaccatc

14161 ttggccaggc tggtctcgaa ctcctgacct caggtgatcc acttgcgtcg gcctcccaaa

14221 gtgctgggat tacaggcgtg agacaccgca cccagccttt tttttttttt ttttctttta

14281 agacagaatc gctctgtcac ccaggctgga gtgcagtggc acaatctcgg ctcactgcaa

14341 cctctgcctc ccaggtttaa gcaatccacc tatgtcagtc tcccaagtag ctgggattat

14401 aggtgcatgt caccatgcct ggctaatttt tgtactttta gtatagaaag tacaccatgt

14461 tggccaggct ggtcttgaac tcctgacctc aagtgatccg cctgcctcag cctcccgaag

14521 tgctggaatt acagacatgt gccactgcac ccggcctggt tttttttttc taagagatgg

14581 agtctcactt ttctgcccag gttggagtgc aatggcacca tcatagctca ctgcagcctt

14641 caactcttgg cctcaggcaa tccttgcacc ttagcctcgc aaagtgttgg gattacaggc

14701 atgagccact gagccttgcc tggacttttt tttttttttg agatggcgtc tcgctctgtt

14761 gcccaggttg gagtgctacg gcatgatctt ggctcactgc aacttccacc tcccaggttc

14821 aagcgattct cttgcctcgg ccccccgagt agctgggatt acagcatgcg ccaccgtgcc

14881 tggctaattt tggtattttt agtagagata gggtttcatc atgttgggca ggctggtctt

14941 gaactcctga cctcgtgatc cacccacctc ggcctcccaa agtgctggga ttataggcat

15001 agccaacgcg cccagcctgg acttgttttt aaaagatcac tgtggctcct gtgtttaggc

15061 tggctggtag gagacaggtg gcagtgacat tgatggtgaa gagaaaatag tggcagccat

15121 ggagatggag agaagtagac aagtttggga tatattatac attccagggg tagaaacaac EPI-109 819

15181 aggactagat gatggattga tgggtgggag atgtagatac tgggagagaa gcaggattct

15241 gatggatgga aaaactaaaa aattctattt tgggtgtggt aagtctaagt ctattagaca

15301 tgcaagtaga gatgtcactg ggcagataca catctggatt tcaggggcaa ggtccaagct

15361 agagaaagaa acctgggcat ggtcagcatg aggatggtgt ttaaagccat ggaacttatc

15421 ttgtgcatcc ctataagacc cctttgaggc acttgtttcc cctcacaatg gatgcagtgc

15481 atcttccatt ctgaattcca gaggcaacaa cctcctgctc ctagaagcta aactctccag

15541 acttagtctt ctgaattccc actgggattt aacctccctg gattcaattc cctaccccac

15601 aaggaccctt ctaccaatcc atttcacaat atttggtgga actcttcaca ttttcaaatc

15661 ctgtcttcta tgtttgaaag cattttcctc tgggcatttt gaaacctggc tttcccctaa

15721 tgatgctact cctctctgtg gtgaaggttg ctctttcttc gactccatca ctaggggaat

15781 gaaggcagaa gagaggggtc gttatcccct ctcccccagg accactgata aactcctcct

15841 catctcccaa agcacgtgcc ttctggatct gccatgctct ccctgccttc acagcacaat

15901 cttatccatc aaaatattta ttatgctctt aacaacttgt ataactagct cagtctttct

15961 ccacatctta tccctaccat catccttgtt tgtttgtttt ttgagacaag gtattgctct

16021 gtcacccagg ctggagtgca gtggcgtgat cttggctcac tgcagcctcg acctcctggg

16081 ctcaagtgat cctcccacgt cagcctcctg agtagctagg actacaggcg cataccacca

16141 tgcccggcta agttttgtat tttttttttt ttccagagat agggttttgc tatgttgcct

16201 aggctggtct tgaactcctg agctcaagca atccacccgc ctcagcctcc caaagtgctg

16261 ggattacagg catgacccac cgcacccggc ctcctaccac catctttagt

(2) INFORMATION FOR SEQ ID NO: 2654: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2654

1 ttctccttct ccccaacagt tccccaggga cctctctcta atcagccctc tggcccaggc

61 agtcagatca tcttctcgaa ccccgagtga caagcctgta gcccatgttg tagcaaaccc

121 tcaagctgag gggcagctcc agtggctgaa ccgccgggcc aatgccctcc tggccaatgg

181 cgtggagctg agagataacc agctggtggt gccatcagag ggcctgtacc tcatctactc

241 ccaggtcctc ttcaagggcc aaggctgccc ctccacccat gtgctcctca cccacaccat

301 cagccgcatc gccgtctcct accagaccaa ggtcaacctc ctctctgcca tcaagagccc

361 ctgccagagg gagaccccag agggggctga ggccaagccc tggtatgagc ccatctatct

421 gggaggggtc ttccagctgg agaagggtga ccgactcagc gctgagatca atcggcccga

481 ctatctcgac tttgccgagt ctgggcaggt ctactttggg atcattgccc tgtgaggagg

541 acgaacatcc aaccttccca aacgcctccc ctgccccaat ccctttatta ccccctcctt

601 cagacaccct caacctcttc tggctcaaaa agagaattgg gggcttaggg tcggaaccca

661 agcttagaac tttaagcaac aagaccacca cttcgaaacc tgggattcag gaatgtgtgg

721 cctgcacagt gaattgctgg caaccactaa gaattcaaac tggggcctcc agaactcact

781 ggggcctaca gctttgatcc ctgacatctg gaatctggag accagggagc ctttggttct

841 ggccagaatg ctgcaggact tgagaagacc tcacctagaa attgacacaa gtggacctta

901 ggccttcctc tctccagatg tttccagact tccttgagac acggagccca gccctcccca

961 tggagccagc tccctctatt tatgtttgca cttgtgatta tttattattt atttattatt

1021 tatttattta cagatgaatg tatttatttg ggagaccggg gtatcctggg ggacccaatg

1081 taggagctgc cttggctcag acatgttttc cgtgaaaacg gagctgaaca ataggctgtt

1141 cccatgtagc cccctggcct ctgtgccttc ttttgattat gttttttaaa atatttatct

1201 gattaagttg tctaaacaat gctgatttgg tgaccaactg tcactcattg ctgagcctct

1261 gctccccagg ggagttgtgt ctgtaatcgc cctactattc agtggcgaga aataaagttt

1321 gctt

1 tacgggccgg gcactcccga gctgctgctc gagggcgccg agacggtgac tccagtgctg

61 gacccggcca ggagacaagg gtacgggcct ctctggtaca cgagcgtggg gttcggcggc

121 ctggtgcagc tccggagggg cgagagggtg tacgtcaaca tcagtcaccc cgatatggtg

181 gacttcgcga gagggaagac cttctttggg gccgtgatgg tggggtgagg gaatatgagt

241 gcgtggtgcg agtgcgtgaa tattgggggn ccggacgccc aggaccccat ggcagtggga

301 aaaatgtagg agactgtttg gaaattgatt ttgaacctga tgaaaataaa gaatggaaag

361 cttcagtgct gccgataaag atgctgagtt gcgacacacg tcttaattca gggtgggtgc

421 acgggtgcgg gttaaatatt ctcagtactc ttctggttgc ttgaaacaat tcatcacaac

481 acagtgtatg gcctttgctc ctagggatga tggtctgcct gtcccacccc ctccctgcct

541 ctgaatggcc aggccccacc attagcccag ttggagggtg ggaggaaggg ggacttctca

601 aactccgaag cttctctagg catcctgatt ttcagggcca catggtccca accagactct

661 gcaccatact cttttctctt gggtaccccc caacagtgag aggggtcatt acagagccca

721 gcaagcacca ctcagaaagg cccagcagca gagtaagccc ctatcatgac agaggaatga

781 agcctggagg ggccccgcac ttctccccct agagctgcct gaaggcctct ctgtctccta

841 cccgacagtc aactcttctc ctccaaggag cttaattcaa ggctcatggg gtctgaaggg

901 aggaggctga aggagaaaga aggggagaat attagagaga gatggggatg gcaggaagga

961 gcctgtggtg cctgaaaaca ccaggaagtt ctggggagga ggaaaaaccg atgccccact

1021 tagggtgtcc catttagggt gagacggaaa atcctcacct ttttttcaca ctttaggtcc

1081 cccttcccaa aagtgagtaa gtgtgggtgc ttctgggatg agtaacagtg tcccccatta EPI-109 820

1141 cttcatggct gactttcagc cacaggctgg aggaggcaga gggtgaccca aggccctatc

1201 taggtcaccc caatgggtca ccctaccccc tcagcctacc acatggtttt ctcctgcctg

1261 gcaccccagg gctggaggta aagcctaatt ttccgaactt cagttggggc tcccagtcta

1321 ggggggctca atttccgtct ccatattttg ttttggaatt attatttttt tgagacaggg

1381 tctcgttctg tcacccagac gggggtacag tggcatgatc atagcttact gtaacctcaa

1441 actcctgggc ttgagtgatc ctcctgcctc agcctcctga ggagctagga ttacaggcat

1501 gcaccactac acctgactaa tctttaattt tttttctaga aacaaggtct tgctatgttg

1561 cacaggctgg tcttgaacta gtgggctcaa gtggtcctcc cacctcagcc tcccaaagtg

1621 ttgggataac aggcatgagc cactgcgccc cacccttatt tgtctttgac tctctccaga

1681 agagccttca tccagggagg gggtgctttt ctctttccgg attacccacc tctcacctct

1741 cccctccttc accacaaaga ccagtgggac caagccggca tgtgagtcct tcacccacat

1801 cttattccta tgtttcattc ttttttaaaa aatagagaca ggatctcact atgttgccca

1861 ggttgctctg gaactcctgg gttcaagcga tcctctcacc ttggccttgc aaagtggtag

1921 gattacaggt gcatgccacc acgtccggca gttcggttcc ttgttcttta ttgtcctcag

1981 tctcttcgat ttcacccact gagagaatgg aaggggatag aacagctgga aactggttga

2041 aggaagccag aattcactaa gtgcccactg tgccaagggc tgagtgaggt cctctgatgg

2101 aggtcaggcc ttctctcaca tgccctatgt gtggtggaca ttcctatccc cattggatag

2161 ataggttaag tggctggttc aggttgcaga gttaggacag ggtgatttga agcctagaca

2221 cccgaatctc tggaagtccc ttggctgtgt gattcaggta cctgagaatg cggctcctct

2281 ccagctctct ccggactgct ggccagctgc aacagccgga aatctcacct gagctgcagg

2341 attttcccag caaggattgg aattcccaga gttggaaatt cccatgccct gagggagagg

2401 taattaggtt caggctcttg tttcctgggg gatggggaat attctgttgg gctttgttta

2461 tgtagggtct ccagggccct aggagtctaa ggatgggact gggtccgagg gatcttaaag

2521 cctgtggaga gaggacttag ggagcttctt cccacccaca agaagaggca gatgcagaat

2581 taattccaag aaggagacca tgtttctttt ctaagcaaac tttatttctc gccactgaat

2641 agtagggcga ttacagacac aactccctgg ggagcagagg cctcagcaat gagtgacagt

2701 tggtcaccaa atcagcattg tttagacaac ttaatcagat aatattttaa aaaacataat

2761 caaaagaagg cacagaggcc agggggctac atgggaacag cctattgttc agcctccgtt

2821 ttcacggaaa acatgtctga gccaaggcag ctcctacatt gggtccccca ggataccccg

2881 gtctcccaaa taaatacatt catctgtaaa taaataaata ataaataaat aataaataat

2941 cacaagtgca aacataaata gagggagctg gctccatggg gagggctggg ctccgtgtct

3001 caaggaagtc tggaaacatc tggagagagg aaggcctaag gtccacttgt gtcaatttct

3061 aggtgaggtc ttctcaagtc ctgcagcatt ctggccagaa ccaaaggctc cctggtctcc

3121 agattccaga tgtcagggat caaagctgta ggccccagtg agttctggag gccccagttt

3181 gaattcttag tggttgccag cacttcactg tgcaggccac acattcctga atcccaggtt

3241 tcgaagtggt ggtcttgttg cttaaagttc taagcttggg ttccgaccct aagcccccaa

3301 ttctcttttt gagccagaag aggttgaggg tgtctgaagg agggggtaat aaagggattg

3361 gggcagggga ggcgtttggg aaggttggat gttcgtcctc ctcacagggc aatgatccca

3421 aagtagacct gcccagactc ggcaaagtcg agatagtcgg gccgattgat ctcagcgctg

3481 agtcggtcac ccttctccag ctggaagacc cctcccagat agatgggctc ataccagggc

3541 ttggcctcag ccccctctgg ggtctccctc tggcaggggc tcttgatggc agagaggagg

3601 ttgaccttgg tctggtagga gacggcgatg cggctgatgg tgtgggtgag gagcacatgg

3661 gtggaggggc agccttggcc cttgaagagg acctgggagt agatgaggta caggccctct

3721 gatggcacca ccagctggtt atctctcagc tccacgccat tggccaggag ggcattggcc

3781 cggcggttca gccactggag ctgcccctca gcttgagggt ttgctggagg gagggagaga

3841 gggagaggag agtcagtgtg gccatgtcgg ttcactctcc acatcctggc cctcgagctc

3901 tgcccacccc acatccggtt cctgtcctct ctgtctgtca tcccacatcc cacctggcca

3961 tgacgttctg agtatcccac taaggcctgt gctgttcctc cacccttccc ttgagctcag

4021 cgagtccttc tcacattgtc tccaagttct gcctaccatc agccgggctt caatccccaa

4081 atcctagccc tccaagttcc aagacacatc ctcagagctc ttacctacaa catgggctac

4141 aggcttgtca ctcggggttc gagaagatga tcctgaagag gagagagaaa agaaaaagct

4201 gagaccctta aacttcctag aaaatacccc cctactttca cctccatcca tcctccccca

4261 agaccaaaac tttaaatttc ccccactgct ttccataccg gtactaaccc taccccccaa

4321 acccaaaccc agaattagga aagaggtttg gagacactta ctgactgcct gggccagagg

4381 gctgattaga gagaggtccc tggggaactg ttggggagaa ggagaatggt taacatcgag

4441 ggagtcaccc ttaaaggagg aacagctggc tgcctgtctg gcctgcgctc ttagccctga

4501 ggtgtctggt tttctctctc cattcatctg tgtattcacc ttccaggcat tcaacagctc

4561 tttccctgag tgtcttctgt gtgccagaca ccctatcttc ttctctcctt atctccccca

4621 tctctctcct tagctgtcat atttcccgct ctttctgtct caccatcttt attcatatca

4681 cttgtttctt cccccatctc tcttctcaca ccccacatct gtctccatat cttatttata

4741 tatctgcttg ttcattcatt cattcattca ttcactccat acacacttag tgagcacctt

4801 ccatgtgcca gacatcctgt ctctccatct ttctctctct ctcttcccca tctcttgcca

4861 catctctttc tgcatccccg tctttctcca cgtttttttc tctccatccc tccctatcag

4921 cgcacatctt tcacccatcc catctctctc cctctcttgc gtctccattt ccccttgggt

4981 gggagagtgg atgaaggctg gccaggcact cacctcttcc ctctgggggc cgatcactcc

5041 aaagtgcagc aggcagaaga gcgtggtggc gcctgccacg atcaggaagg agaagaggct

5101 gaggaacaag caccgcctgg agccctgggg cccccctgtc ttcttgggga gcgcctcctc

5161 ggccagctcc acgtcccgga tcatgctttc agtgctcatg gtgtcctttc caggggagag EPI-109 821

5221 agggtggagc cgtgggtcag tatgtgagag gaagagaacc tgcctggcag cttgtcaggg

5281 gatgtggcgt ctgagggttg ttttcagggg gggtctgtag ttgcttctct ccctcttagc

5341 tggtcctctg ctgtccttgc tgagggagcg tctgctggct gggtgtgcca acaactgcct

5401 ttatatgtcc ctggggcgag aggagggcgg ggaaagaatc attcaaccag cggaaaactt

5461 ccttggtgga gaaacccatg agctcatctg gaggaagcgg tagtgggccc tgcaccttct

5521 gtctcggttt cttctccatc gcgggggcgg ggatttggaa agttggggac acacaagcat

5581 caaggatacc cctcacactc cccatcctcc ctgctccgat tccgaggggg gtcttctggg

5641 ccactgactg atttgtgtgt aggaccctgg aggctgaacc ccgtccccat gcccctcaaa

5701 acctattgcc tccatttctt ttggggacca ggtctgtggt ctgtttcctt ctaacttcca

5761 gacaggatgc aggaaaaaga tagaactaga actgggaggg gcttcagaaa gctgagtccg

5821 ttgagggaga gaaaacgggg ttggagggaa aagctgtgtt gagtcctgag gcctgtgttt

5881 gggccctgcg gggagaagga gctgggggct tggtggcagg cttgaggcct caggaaaggc

5941 tgggtgcggg tagcagggac aagcctggga cagccccggg gagtgaaatc acccccggga

6001 attcacagac cccactgggg caggccctct tctttcattc tgacccggag actcataatg

6061 cttggttcag tcttggcttc caaggaactc tggggtccct gatttttttc atgaagctct

6121 cacttctcag ggccccagtg tgtggccata tcttcttaaa cgtcccctgt attccatacc

6181 tggaggtcct ggaggctctt tcactccctg gggccctcta catggccctg tcttcgttaa

6241 gtgggggtcc ccatactcga cttccatagc cctggacatt ctcctaccca ttgctgtggt

6301 cacatctccc cagaggtctc ctgtaaccca ttcctcagag ccgctacatg tggccatatc

6361 tcccaggagc tccctgaccc ccgcccctcc agaccctgac ttttccttcg tcttctcagc

6421 ttctcctttg cttcccctgc agcagtctgg cggcctcacc tggtgagtcc atcacatatc

6481 cctgaagctc tctgagccct tatccttttg ttctccccac agctcttgct ccctttgagc

6541 cctctgtccc tccctccatt ccttagatag actgggaagt tctcactccc agacacacac

6601 acacaagcag acagcatttc agagaaaaga ggtttattgg gcttcatcga gggtgcagat

6661 gcctccgtgt ggggctctgg tcggcagctg gctttcagag cctttccctg ccttctgggg

6721 ccctgtgatc cctcatgcct acttctttct ctcttggtca gccttgtgcg catgccctct

6781 cactcttcat ctcttgggcc tgtctctgtt tctccttgga tgttcttcta ttattcccct

6841 ctctccatcc tccataaata aataatttaa tttttttgcc ttcataaata gtcccctccc

6901 tgcctctagt catcccccaa gctcctccat gtgcctgctc ttcctctgtg tgtggatcta

6961 ggccccacct agctggtggg acagaccaac agctttgggc tgggaattcc taggcaggct

7021 tgaaatcctc agccagacag acatcaggga tggttcaggg aggtgtggtc ccctgggatg

7081 cctagaattc cttctttgaa agctccggtg acttgatcag ggaagacttg agctgttgga

7141 atggccaaag gagaggtggt gacgacccct gaaatggtca gaatggaggc agaatgggga

7201 gaaggtcttg aaatcaatta ttttttcttt ctggattttt ccaagttcta cagagcgaag

7261 gctccaaaga agacagtact agggctgagg actaggtggg ggatgccatc tgtgtgggtg

7321 gatagctggt ctccctgggt gagctggaac gcagccccgt ggtacatcga gtgcagccag

7381 ggttcctgca gccctggata caccatcttc tgggagctga ggagaggcac atggaagggg

7441 tactgggagg agaagagctg gacctcatgg gccaggtaga gtggggagga ggtggccttg

7501 ggagagtagg ctttcccaga gaagaccacc tgggagtaga cgaagtagat gccactggtg

7561 gggaccagga gagaattgtt gctcaaggag aaaccatcct ggaggaaggc acggtccgtg

7621 tttgctctcc agagcagtga gttctgcttg ctggggtctc ctaggaagag ccatagggga

7681 tgggggtggg agatcagggg tctggatcag aggtctcaat ccctgaggaa gtgggcactg

7741 aacaactgag ttcctggggg atggcagggg gaggcatagg agtgggctcc ctctgttttt

7801 tttagcgtgg gggaagttgg gggagagggg tggatgcttg ggttcctgag gcaggggtag

7861 gaggagagct ggtggggaca tgtctgggag gtcaggtgga tgtttaccaa tgaggtgagc

7921 agcaggtttg agggtgctgt gggcaagatg catcttgggg tgctgacggg cagtctgggc

7981 agctgaaggt gtgaggccaa caccagggag cccctagggg agaacagagt tgaggggggc

8041 tctagggctc aaggtttggc tgagccaccc cagcagcccc cattctcctg ctgcctcacc

8101 tgggccccag gcagcagaac cagcagcagc cccagaagga ggaggtgtag ggtggtgcca

8161 cgcacccttg ggaggaagag acgttcaggt ggtgtcatgg ggagaacctg cagagaaaga

8221 gagagagaga gagagacagt gagcggggcg gggcacgcgg cggaagacag acctcccgcc

8281 ctgggagaca gcaccccccg acccccgaga gagagatcga cagagaaggg gacaagatgc

8341 agtcagagaa accccaaggt gagcagaggg agacagagag agacaggaag ggaacagaga

8401 ggaatcatgg cagaaacaga gaatgtgtga cagagacaat gagactgaca gatggagagt

8461 cagagacaga gaaggaaacc aaaaccaaac ccaccaaggc ccaggcccag gcaggccggg

8521 gatccaggca gcaggtgcag gagggaccga ggcccaggca gagggcagga cactgcgggg

8581 cggtagtcca aagcacgaag cacgggcagc ccaaggagat ggggcaggag agcctcacct

8641 gctgtgcgga cccctgggcc cggacgctca ggtcccttta tagaggaagc ggcagtggca

8701 gcgtggcagg cagcgggcgg gttctaggtc ggggctgggg cccggggaag cccccagggc

8761 ttagaagata ctgctgtttc agtcaaaggc aggaaaggct gaggcctagg agagaaccac

8821 aggctggggg ttcaggcgac tgagttctgg gaaagggagt cgggtcaggg gaatcgtggg

8881 ctgggagggc cagggagtgg ggtcaggcct agagttccaa agaagggaca gtcaattcag

8941 agaggaggca gttgagcagc tggggtgtga gctggaggcc cggttccctg aagagcaatc

9001 atatataaca tctctgcacc cttggctgag tacaggcttc tctctttgcc catttccttc

9061 tcttgtaccc ctgtccttgt cccaaacaac tcaaatcata cttgtcccag tatacggact

9121 ttccagccca tctggcaggt ttcacatcaa gaaggtccat tatatatccc cttcatcggg

9181 gacattctgg tgtttgcctc ttgtccaggt gaaaatatta atggatcccc cttccactct

9241 tgaaagtgtc ctagtttgga agataaattt tttggtcccc ttactcagag atgatgctgg EPI-109 822

9301 acagtcaagt atgatgaggt ctcatctcac tcctgaagga tgccctccat ctcttcctga 9361 cttcaggtgg cttccacaga acagatttat ataaccccaa ataaacacac attccaggat 9421 caatgtggca gacaccttcc aaagttttct acaaaggaag tttgcagaat tccacatggg 9481 tgaggcttaa gggtggtgac ttagggtggg gtggggacag ctaagggact tgttctgaag 9541 ctgcatttgc agagccaata cattatttta aaattgttcc aggcctggtg cagtggctca 9601 cacctgtaat cctggcactt tgggagtctg aggtgggcgg attacttgag gtcaggagtt 9661 tgagaccagc tggccaacat ggtgaaaccc catctctata ataaatacaa aaattagcca 9721 ggcgtgctgg tgcgcatctg cagtcccagc tactcgggag gctgaggctg gagaattatt 9781 tgaacctggg aggcggaggc tgcagtgagt caagatcgca ccactgtatt ccagcctggg 9841 ggacagagca agactctgtc tcaaaaaaaa aaaaaaagtt tccaaaattt ttttcctttt 9901 tattgatatg taacttaggt atgaggtgga cacctcttaa gtgtacagct gatgaatttt 9961 tccatctgta tgtagccacc acccagctcc acgtattttc aggtccccag caggttccct 10021 catgccccct ccctgctgat accctccaaa gataaccaac cactctctca cttttatcac 10081 catagattat ttcctcctgg tttggggcat catataaatg aaatcacaca gaatgtactc 10141 atttctgttt gacttctttc agtcagcatt atgtttgtga gattcatata cgtggttgta 10201 tgtatcagta atgtttttta aaaaaattat gatgtaatat tctattgtat caatatattc 10261 taatatattc tgttgatggg gatttggttt gtttctagtt tttgtctaac acaaaaatgt 10321 ctacacgaac attctcatac atgagcccat ttcacttagc ttgcaagtta caaggtttaa 10381 aaaaagcagt ttctaaagat gactttattc acttttccta agtttgagat aataccaact 10441 tgtcacctca aatattatta ctgctactca tgtgatttta cttggagagt gttagagggg 10501 ttggagctgg ggctggtggt gacccggggt aaagcccact gttgcatggg gcagaccact 10561 tctctcccca ggcacaaggt ccctgagggg tcttggtgta acatggaggg acatgtaagt 10621 aacattctgg gtgtgtatga gctatttctc ctgttcttct ctacttgagg acctgcccct 10681 ttgcctttta tgctttacta gtcttagcta ttatttctgt aggggcagaa aggggtgatc 10741 ccttcctgac ccatcataag ggttatggcc aatactccta taataaaaga cagattaaca 10801 agagaaaagc ataatacatt tatttaatca aagttttagg tgacatggga gccttcagaa 10861 atgaagaccc aaggacccag gggaaaacta tttttatgct tagatttgat gaagaatgaa 10921 cagctgtgca gaaatgtaat tgaacaaaag gagtatcatc taatggtcac agactgggac 10981 tggggggatc ccagcaaggc ctggccatat tcttcttggt ctctctgtac agcattcctt 11041 cctcccaggt atagggcaga acctcttctg gaatgagggt cttataacct actatcagat 11101 gagataagtc agaaaatttc ttttcctttt tttttttttg agacagtttc tcactgtcgc 11161 acaggctgga gtgcagtggc acgatcttgg ctcactgcaa cctctgcctc ccaggttcaa 11221 gctattctcc tgcctcagcc tcccgagtag ctgggattac aggcacacgc caccaagccc 11281 gccaaatttt tttttgtatt tttagtagag acggggtctc accatgttgg ccaggttggt 11341 cttgaattcc tgaccacagg tgacccacca gccttggcct cccaaagtgc tgggattatg 11401 ggcgtgagcc actgcgccca accttcttct cattctttta accttattat ctcttgtgtc 11461 agtgtgggtt tcccttttag cccctgctcc tttctttttc tctgtgttgc cctttctctc 11521 agggtccttt ttgcttcctg ttgtctcttt ctgcttctct aatggtatga gctgatggac 11581 tgggacccca gctgagctat attaaaatat aaaatgttat tacaaggcca ggagcagtgg 11641 cacatgcctg tcatcccagc actttgggag gctgaggcga gcagatcaca aggtcaggag 11701 atagagacaa tcctggctaa tacggtgaaa ctccatcact gctaaaaata caaaaaatta 11761 gccgagcatg gtggcacgcg cctgtaatcc tagctactag ggaagctgag gcaggagaac 11821 tgcttgaacc caggaggcgg aggttgcagt gagccgagat cgtgccactg ccctccagcc 11881 tgggcaacaa agtgagactc catttcaaac aaaccaacca aaaaacaaaa caaaacaaaa 11941 caagcaaaca aaaaaaggta ttgcaattaa cagtgagaca cagagagaaa tttaaattaa 12001 agaggaagaa tgggacattg aaagacaaaa aagggaaggc aagaagggtg atggggagac 12061 atgagagaca cagaggaagg aagggtaaga ctgggctgag gctcagtgtc acgtgcatgt 12121 gagatatgcg aaggatgctc cttgagatgg gccaatcttg gtttcaatct cagtttcgga 12181 ggttgtatga atttggtttc tttcttggca ggccagcagt tggtttggga ctttccctgg 12241 gtgggagagc tgatgactgg agtcttgtgc cccagactca gggaaataca gtctttatag 12301 tggtctttgt ggagaaacta gtgaaatctc tgaagcctcc aaatgagact gaaatgacat 12361 tagcttcaaa cttgaactta gcctcaaaac ctgaattggg atttaatacc aacatcaacc 12421 ctaacccaaa tttaacctca acccaaatca caactcaaac tcaaccccaa ctgtaaccct 12481 aacctcaaat ctaaacacat cccaattaat aaccccctaa ataaaacttc tcctctaccc 12541 caacccaacc ctgtttctag ggctaatctt gaaaccagtt taccaccact cctaacacta 12601 aacttaaatc tgactctaaa tgtaagtcca atctgagcca caagcctaaa gttgaacttt 12661 atcctgcttt atgaattatt catccattcc tccatttagt gagtatctgc gtgcctaaca 12721 catgctgggc attgtcctaa ggcaggaggg acatggaggg caaagggatc agagaaggta 12781 ccagcacctg tggagcttgt attccagtga ggcccagacg gaaaaagaaa gaaacttgaa 12841 ggaaggaaat ttggtactat gagaaaataa gacaggctga tgttgtaaga gtggcaggga 12901 gctactttta aatacagtag tcagcaaaat cctctttgag tgtttgggtg gcactggagc 12961 tgagacccaa atgacaaaaa atagtgacca ggtaaaagtt tgggagcaaa gcatttcagg 13021 taaagggagc agctactgca aaggctggaa ggcggaacca agctgggggt gttgacgaca 13081 aacagaaggc cagtgtggct ggagcagaga gagagactgg gaggcgggtg ggagatgagg 13141 tcagagagga gggcaggggc caggtcatgc agggccatgc aagaagggta aagcctctag 13201 atttcatcca gccacaggaa gcctttaaag gtcgtcagag tgtgtggtgc gtgcgtgtgt 13261 gtgtgtgtgt gtgtgttgca ggggagagag gnggagggag agagagagag agagaagagg 13321 gaggtgagca gaggtgattg gatttttttt tcttttgaca tggtgtcttg ctctgtggcc EPI-109 823

13381 taggctggag tgcagtggca ccatcatagc ccactgcaac ctcaaaacca tgggctcaag 13441 tcatccttcc acctcagctt cccaagtatc taggactaca ggtgtgtgcc actgtgcctg 13501 gctaatttta aaaaatattt taaaattttt gttgagacag ggtctatgct gctcaggctg 13561 gtctcgaact cctggtttca agtgatctgc ccatcttggc ctcccaaagt ttttttttgt 13621 tagtttgaga ggcggtttcg ctcgttgccc aggctggagt gcaatgactg atctcatctc 13681 actgcaacct ctgcctcctg ggttcaagcg attctcctgc ttcagcctcc caagtagctg 13741 ggattacagg tgcatgccac cattcccggc taattttttg tatttagtag agatggggtt 13801 caccatgtta gtcaggctga tctcaaactc ctgacctcag gtgatccgcc tgcctcagcc 13861 tcccaaagtt ttgggattac aggtgtgagc caccatgctg ggccagcctc ccaaagtttt 13921 gggattacag gcatgagtca ccacactggc cctggatttt ttttctttct tttttttgga 13981 gacggagtct cactctgttg cccaggctgg agtgcaatgg cgtaatctca gctcactgca 14041 acctctgctg cccgggttca aacgattctc ctgtcttagc ctcctgagta gctgggatta 14101 taggtgcatg ccaccatgcc tggctaattt ttgtactttt agtagagaaa gtacaccatc 14161 ttggccaggc tggtctcgaa ctcctgacct caggtgatcc acttgcgtcg gcctcccaaa 14221 gtgctgggat tacaggcgtg agacaccgca cccagccttt tttttttttt ttttctttta 14281 agacagaatc gctctgtcac ccaggctgga gtgcagtggc acaatctcgg ctcactgcaa 14341 cctctgcctc ccaggtttaa gcaatccacc tatgtcagtc tcccaagtag ctgggattat 14401 aggtgcatgt caccatgcct ggctaatttt tgtactttta gtatagaaag tacaccatgt 14461 tggccaggct ggtcttgaac tcctgacctc aagtgatccg cctgcctcag cctcccgaag 14521 tgctggaatt acagacatgt gccactgcac ccggcctggt tttttttttc taagagatgg 14581 agtctcactt ttctgcccag gttggagtgc aatggcacca tcatagctca ctgcagcctt 14641 caactcttgg cctcaggcaa tccttgcacc ttagcctcgc aaagtgttgg gattacaggc 14701 atgagccact gagccttgcc tggacttttt tttttttttg agatggcgtc tcgctctgtt 14761 gcccaggttg gagtgctacg gcatgatctt ggctcactgc aacttccacc tcccaggttc 14821 aagcgattct cttgcctcgg ccccccgagt agctgggatt acagcatgcg ccaccgtgcc 14881 tggctaattt tggtattttt agtagagata gggtttcatc atgttgggca ggctggtctt 14941 gaactcctga cctcgtgatc cacccacctc ggcctcccaa agtgctggga ttataggcat 15001 agccaacgcg cccagcctgg acttgttttt aaaagatcac tgtggctcct gtgtttaggc 15061 tggctggtag gagacaggtg gcagtgacat tgatggtgaa gagaaaatag tggcagccat 15121 ggagatggag agaagtagac aagtttggga tatattatac attccagggg tagaaacaac 15181 aggactagat gatggattga tgggtgggag atgtagatac tgggagagaa gcaggattct 15241 gatggatgga aaaactaaaa aattctattt tgggtgtggt aagtctaagt ctattagaca 15301 tgcaagtaga gatgtcactg ggcagataca catctggatt tcaggggcaa ggtccaagct 15361 agagaaagaa acctgggcat ggtcagcatg aggatggtgt ttaaagccat ggaacttatc 15421 ttgtgcatcc ctataagacc cctttgaggc acttgtttcc cctcacaatg gatgcagtgc 15481 atcttccatt ctgaattcca gaggcaacaa cctcctgctc ctagaagcta aactctccag 15541 acttagtctt ctgaattccc actgggattt aacctccctg gattcaattc cctaccccac 15601 aaggaccctt ctaccaatcc atttcacaat atttggtgga actcttcaca ttttcaaatc 15661 ctgtcttcta tgtttgaaag cattttcctc tgggcatttt gaaacctggc tttcccctaa 15721 tgatgctact cctctctgtg gtgaaggttg ctctttcttc gactccatca ctaggggaat 15781 gaaggcagaa gagaggggtc gttatcccct ctcccccagg accactgata aactcctcct 15841 catctcccaa agcacgtgcc ttctggatct gccatgctct ccctgccttc acagcacaat 15901 cttatccatc aaaatattta ttatgctctt aacaacttgt ataactagct cagtctttct 15961 ccacatctta tccctaccat catccttgtt tgtttgtttt ttgagacaag gtattgctct 16021 gtcacccagg ctggagtgca gtggcgtgat cttggctcac tgcagcctcg acctcctggg 16081 ctcaagtgat cctcccacgt cagcctcctg agtagctagg actacaggcg cataccacca 16141 tgcccggcta agttttgtat tttttttttt ttccagagat agggttttgc tatgttgcct 16201 aggctggtct tgaactcctg agctcaagca atccacccgc ctcagcctcc caaagtgctg 16261 ggattacagg catgacccac cgcacccggc ctcctaccac catctttagt

>) INFORMATION FOR SEQ ID NO: 2655: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2655

1 aattcgataa ttcaaaatga tatttcagtg gggacaaggc caaaccatat tatgtgcttt 61 atgctactaa taaaaaggtt aaaccgaaca agttcaaaga caaaactcag tagtacttta 121 ttcagacagg ttagtctaaa tctgttaacc ttatacttgc aactctgatc attcattaat 181 tctgcaaatt ttaataaatg ctttatttta agctaaatgc tgagatgaaa aaatgaaacc 241 atatgagtta gcaaagtaga aaatataggc atattaatca gtaaatgcag aatgataaat 301 gctccatcaa tatgcacttg ttgtagtgag gccaccgagg agggtgcaat cctctcaacc 361 tgggaggagc aggtaggact tcagatgtca tccaactcaa agatatagtg agggacttga 421 tcaaacattt gccaagacca ctatgagtta aatgaataga ttaggcattt ctccaatgtt 481 gcaagcttcg aatcatatcc aaactcagaa caacatagct tggtcataat gatcccaagg 541 atcctattgg ccattgtctt tgagcctcaa aggaacatat taaaactcca taataccctt 601 ttgatctatt ctgaagttaa gtagtgaatt tacatgatga tgacacaaac actgtaaagg EPI-109 824

661 acctctgggt tacttgttta taagctagta tttcctgaat caatttttct gatccctaga

721 tatttggtag gtgaagtcat acctatatat ccccacaccc tagaacagca tctccaactt

781 ttttttccct ccttgtcttt tagtgggagc cacatcagta tccaaggagg agatccagaa

841 gcctctccaa ccaggtaggg acagttatag attccagacc tcagctatgg cctttgttac

901 agagtacaaa tgttatatag tacaagttta ttgtacacat cccattgagt ctctgagctt

961 tagaattttc ttgtagaatt taacagtttt ttcatgccgt atttacatat tattgctagt

1021 atttagaatt ttcttctcca aatgtataac gtttattatt gcattttttg tatccactaa

1081 gtggaaaatc atgcattaga tattgtagaa gtagatacaa caatgaacaa gaactggtcc

1141 tgaccatgag aggaactgat gatccaatgg gggagataga cctgcacgtg tttaataaaa

1201 ggaagtggct attccggttt ctttttgatg ggcaagcatt ttgcaaggcc ttgggctatg

1261 tgtgtgcaag gctaagccag ttagttaatt gggatttttt taaaaaggca cttcactggg

1321 gggaaaagga acatagagtt ggttattgtc cccttgccta taataaaaac ctattatttt

1381 taatttttta actgggtttg cggttaaatc tcacagccca agagatttgc cacttcagat

1441 ggattccata cacttgcatt taagtatgca aaaaaattcc aattatccag caatttaacc

1501 aaattattgg taacttttct aaaacaaaaa aaaattgttt cccttgtttt ggcagcaatt

1561 tcagttacag tcctttactt tctactcaag aaaatagttt caaaaagttg atgtttgttg

1621 ctaaaagaac tatttttatg aataaatata aaactaagaa gttatggtgt ccctttttta

1681 aaaaatgact catcaaaaga aataactttt tcctttctct tgtaagagaa aaaaattaat

1741 ctcttttaga attgcaaaca tatttccttg atggagaaaa tcaattcaca tggcatagtc

1801 gttatttatc cagttcaaaa accagagtag aatttactac tctgtctcca ttttttctct

1861 ccccaccccc ttaacccaca ttggattcag aaagcttcat tctgcaatca gcattgtcct

1921 ttatctttcc agtaaagata gccttttgga gtcgaagatg aggaaaagcc tgtattttat

1981 agtcttggaa gtgtcttctt ttgccaggac agagagagga gcttcagcag tgagagcaac

2041 tgaaggggtt aatagtggaa cttggctggg tgtctgttaa acttttttcc ctggctctgc

2101 cctgggtttc cccttgaagg gatttccctc cgcctctgca acaagaccct ttataaagca

2161 cagactttct atttcactcc gcggtatctg catcgggcct cactggcttc aggagctgaa

2221 taccctccca ggcacacaca ggtgggacac aaataagggt tttggaacca ctattttctc

2281 atcacgacag caacttaaaa tgcctgggaa gatggtcgtg atccttggag cctcaaatat

2341 actttggata atgtttgcag cttgtaagtt atttcccttc atctgtttca aatgtt

(2) INFORMATION FOR SEQ ID NO:2656:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2656

1 atgcctggga agatggtcgt gatccttgga gcctcaaata tactttggat aatgtttgca

61 gcttctcaag cttttaaaat cgagaccacc ccagaatcta gatatcttgc tcagattggt

121 gactccgtct cattgacttg cagcaccaca ggctgtgagt ccccattttt ctcttggaga

181 acccagatag atagtccact gaatgggaag gtgacgaatg aggggaccac atctacgctg

241 acaatgaatc ctgttagttt tgggaacgaa cactcttacc tgtgcacagc aacttgtgaa

301 tctaggaaat tggaaaaagg aatccaggtg gagatctact cttttcctaa ggatccagag

361 attcatttga gtggccctct ggaggctggg aagccgatca cagtcaagtg ttcagttgct

421 gatgtatacc catttgacag gctggagata gacttactga aaggagatca tctcatgaag

481 agtcaggaat ttctggagga tgcagacagg aagtccctgg aaaccaagag tttggaagta

541 acctttactc ctgtcattga ggatattgga aaagttcttg tttgccgagc taaattacac

601 attgatgaaa tggattctgt gcccacagta aggcaggctg taaaagaatt gcaagtctac

661 atatcaccca agaatacagt tatttctgtg aatccatcca caaagctgca agaaggtggc

721 tctgtgacca tgacctgttc cagcgagggt ctaccagctc cagagatttt ctggagtaag

781 aaattagata atgggaatct acagcacctt tctggaaatg caactctcac cttaattgct

841 atgaggatgg aagattctgg aatttatgtg tgtgaaggag ttaatttgat tgggaaaaac

901 agaaaagagg tggaattaat tgttcaagag aaaccattta ctgttgagat ctcccctgga

961 ccccggattg ctgctcagat tggagactca gtcatgttga catgtagtgt catgggctgt

1021 gaatccccat ctttctcctg gagaacccag atagacagcc ctctgagcgg gaaggtgagg

1081 agtgagggga ccaattccac gctgaccctg agccctgtga gttttgagaa cgaacactct

1141 tatctgtgca cagtgacttg tggacataag aaactggaaa agggaatcca ggtggagctc

1201 tactcattcc ctagagatcc agaaatcgag atgagtggtg gcctcgtgaa tgggagctct

1261 gtcactgtaa gctgcaaggt tcctagcgtg tacccccttg accggctgga gattgaatta

1321 cttaaggggg agactattct ggagaatata gagtttttgg aggatacgga tatgaaatct

1381 ctagagaaca aaagtttgga aatgaccttc atccctacca ttgaagatac tggaaaagct

1441 cttgtttgtc aggctaagtt acatattgat gacatggaat tcgaacccaa acaaaggcag

1501 agtacgcaaa cactttatgt caatgttgcc cccagagata caaccgtctt ggtcagccct

1561 tcctccatcc tggaggaagg cagttctgtg aatatgacat gcttgagcca gggctttcct

1621 gctccgaaaa tcctgtggag caggcagctc cctaacgggg agctacagcc tctttctgag

1681 aatgcaactc tcaccttaat ttctacaaaa atggaagatt ctggggttta tttatgtgaa

1741 ggaattaacc aggctggaag aagcagaaag gaagtggaat taattatcca agttactcca

1801 aaagacataa aacttacagc ttttccttct gagagtgtca aagaaggaga cactgtcatc

1861 atctcttgta catgtggaaa tgttccagaa acatggataa tcctgaagaa aaaagcggag EPI-109 825

1921 acaggagaca cagtactaaa atctatagat ggcgcctata ccatccgaaa ggcccagttg 1981 aaggatgcgg gagtatatga atgtgaatct aaaaacaaag ttggctcaca attaagaagt 2041 ttaacacttg atgttcaagg aagagaaaac aacaaagact atttttctcc tgagcttctc 2101 gtgctctatt ttgcatcctc cttaataata cctgccattg gaatgataat ttactttgca 2161 agaaaagcca acatgaaggg gtcatatagt cttgtagaag cacagaaatc aaaagtgtag

(2) INFORMATION FOR SEQ ID NO: 2657: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2657

1 aattcgataa ttcaaaatga tatttcagtg gggacaaggc caaaccatat tatgtgcttt

61 atgctactaa taaaaaggtt aaaccgaaca agttcaaaga caaaactcag tagtacttta

121 ttcagacagg ttagtctaaa tctgttaacc ttatacttgc aactctgatc attcattaat

181 tctgcaaatt ttaataaatg ctttatttta agctaaatgc tgagatgaaa aaatgaaacc

241 atatgagtta gcaaagtaga aaatataggc atattaatca gtaaatgcag aatgataaat

301 gctccatcaa tatgcacttg ttgtagtgag gccaccgagg agggtgcaat cctctcaacc

361 tgggaggagc aggtaggact tcagatgtca tccaactcaa agatatagtg agggacttga

421 tcaaacattt gccaagacca ctatgagtta aatgaataga ttaggcattt ctccaatgtt

481 gcaagcttcg aatcatatcc aaactcagaa caacatagct tggtcataat gatcccaagg

541 atcctattgg ccattgtctt tgagcctcaa aggaacatat taaaactcca taataccctt

601 ttgatctatt ctgaagttaa gtagtgaatt tacatgatga tgacacaaac actgtaaagg

661 acctctgggt tacttgttta taagctagta tttcctgaat caatttttct gatccctaga

721 tatttggtag gtgaagtcat acctatatat ccccacaccc tagaacagca tctccaactt

781 ttttttccct ccttgtcttt tagtgggagc cacatcagta tccaaggagg agatccagaa

841 gcctctccaa ccaggtaggg acagttatag attccagacc tcagctatgg cctttgttac

901 agagtacaaa tgttatatag tacaagttta ttgtacacat cccattgagt ctctgagctt

961 tagaattttc ttgtagaatt taacagtttt ttcatgccgt atttacatat tattgctagt

1021 atttagaatt ttcttctcca aatgtataac gtttattatt gcattttttg tatccactaa

1081 gtggaaaatc atgcattaga tattgtagaa gtagatacaa caatgaacaa gaactggtcc

1141 tgaccatgag aggaactgat gatccaatgg gggagataga cctgcacgtg tttaataaaa

1201 ggaagtggct attccggttt ctttttgatg ggcaagcatt ttgcaaggcc ttgggctatg

1261 tgtgtgcaag gctaagccag ttagttaatt gggatttttt taaaaaggca cttcactggg

1321 gggaaaagga acatagagtt ggttattgtc cccttgccta taataaaaac ctattatttt

1381 taatttttta actgggtttg cggttaaatc tcacagccca agagatttgc cacttcagat

1441 ggattccata cacttgcatt taagtatgca aaaaaattcc aattatccag caatttaacc

1501 aaattattgg taacttttct aaaacaaaaa aaaattgttt cccttgtttt ggcagcaatt

1561 tcagttacag tcctttactt tctactcaag aaaatagttt caaaaagttg atgtttgttg

1621 ctaaaagaac tatttttatg aataaatata aaactaagaa gttatggtgt ccctttttta

1681 aaaaatgact catcaaaaga aataactttt tcctttctct tgtaagagaa aaaaattaat

1741 ctcttttaga attgcaaaca tatttccttg atggagaaaa tcaattcaca tggcatagtc

1801 gttatttatc cagttcaaaa accagagtag aatttactac tctgtctcca ttttttctct

1861 ccccaccccc ttaacccaca ttggattcag aaagcttcat tctgcaatca gcattgtcct

1921 ttatctttcc agtaaagata gccttttgga gtcgaagatg aggaaaagcc tgtattttat

1981 agtcttggaa gtgtcttctt ttgccaggac agagagagga gcttcagcag tgagagcaac

2041 tgaaggggtt aatagtggaa cttggctggg tgtctgttaa acttttttcc ctggctctgc

2101 cctgggtttc cccttgaagg gatttccctc cgcctctgca acaagaccct ttataaagca

2161 cagactttct atttcactcc gcggtatctg catcgggcct cactggcttc aggagctgaa

2221 taccctccca ggcacacaca ggtgggacac aaataagggt tttggaacca ctattttctc

2281 atcacgacag caacttaaaa tgcctgggaa gatggtcgtg atccttggag cctcaaatat

2341 actttggata atgtttgcag cttgtaagtt atttcccttc atctgtttca aatgtt

1 atgcctggga agatggtcgt gatccttgga gcctcaaata tactttggat aatgtttgca 61 gcttctcaag cttttaaaat cgagaccacc ccagaatcta gatatcttgc tcagattggt 121 gactccgtct cattgacttg cagcaccaca ggctgtgagt ccccattttt ctcttggaga 181 acccagatag atagtccact gaatgggaag gtgacgaatg aggggaccac atctacgctg 241 acaatgaatc ctgttagttt tgggaacgaa cactcttacc tgtgcacagc aacttgtgaa 301 tctaggaaat tggaaaaagg aatccaggtg gagatctact cttttcctaa ggatccagag 361 attcatttga gtggccctct ggaggctggg aagccgatca cagtcaagtg ttcagttgct 421 gatgtatacc catttgacag gctggagata gacttactga aaggagatca tctcatgaag 481 agtcaggaat ttctggagga tgcagacagg aagtccctgg aaaccaagag tttggaagta 541 acctttactc ctgtcattga ggatattgga aaagttcttg tttgccgagc taaattacac 601 attgatgaaa tggattctgt gcccacagta aggcaggctg taaaagaatt gcaagtctac 661 atatcaccca agaatacagt tatttctgtg aatccatcca caaagctgca agaaggtggc 721 tctgtgacca tgacctgttc cagcgagggt ctaccagctc cagagatttt ctggagtaag 781 aaattagata atgggaatct acagcacctt tctggaaatg caactctcac cttaattgct 841 atgaggatgg aagattctgg aatttatgtg tgtgaaggag ttaatttgat tgggaaaaac 901 agaaaagagg tggaattaat tgttcaagag aaaccattta ctgttgagat ctcccctgga EPI-109 826

961 ccccggattg ctgctcagat tggagactca gtcatgttga catgtagtgt catgggctgt 1021 gaatccccat ctttctcctg gagaacccag atagacagcc ctctgagcgg gaaggtgagg 1081 agtgagggga ccaattccac gctgaccctg agccctgtga gttttgagaa cgaacactct 1141 tatctgtgca cagtgacttg tggacataag aaactggaaa agggaatcca ggtggagctc 1201 tactcattcc ctagagatcc agaaatcgag atgagtggtg gcctcgtgaa tgggagctct 1261 gtcactgtaa gctgcaaggt tcctagcgtg tacccccttg accggctgga gattgaatta 1321 cttaaggggg agactattct ggagaatata gagtttttgg aggatacgga tatgaaatct 1381 ctagagaaca aaagtttgga aatgaccttc atccctacca ttgaagatac tggaaaagct 1441 cttgtttgtc aggctaagtt acatattgat gacatggaat tcgaacccaa acaaaggcag 1501 agtacgcaaa cactttatgt caatgttgcc cccagagata caaccgtctt ggtcagccct 1561 tcctccatcc tggaggaagg cagttctgtg aatatgacat gcttgagcca gggctttcct 1621 gctccgaaaa tcctgtggag caggcagctc cctaacgggg agctacagcc tctttctgag 1681 aatgcaactc tcaccttaat ttctacaaaa atggaagatt ctggggttta tttatgtgaa 1741 ggaattaacc aggctggaag aagcagaaag gaagtggaat taattatcca agttactcca 1801 aaagacataa aacttacagc ttttccttct gagagtgtca aagaaggaga cactgtcatc 1861 atctcttgta catgtggaaa tgttccagaa acatggataa tcctgaagaa aaaagcggag 1921 acaggagaca cagtactaaa atctatagat ggcgcctata ccatccgaaa ggcccagttg 1981 aaggatgcgg gagtatatga atgtgaatct aaaaacaaag ttggctcaca attaagaagt 2041 ttaacacttg atgttcaagg aagagaaaac aacaaagact atttttctcc tgagcttctc 2101 gtgctctatt ttgcatcctc cttaataata cctgccattg gaatgataat ttactttgca 2161 agaaaagcca acatgaaggg gtcatatagt cttgtagaag cacagaaatc aaaagtgtag

(2) INFORMATION FOR SEQ ID NO: 2658: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2658

1 gcaggaacag tgctagtatt gctcgagccc gagggctgga ggttagggga tgaaggtctg

61 cttccacgct ttgcactgaa ttagggctag aattggggat gggggtaggg gcgcattcct

121 tcgggagccg aggcttaagt cctcggggtc ctgtactcga tgccgtttct cctatctctg

181 agcctcagaa ctgtcttcag tttccgtaca agggtaaaaa ggcgctctct gccccatccc

241 ccccgacctc gggaacaagg gtccgcattg aaccaggtgc gaatgttctc tctcattctg

301 cgccgttccc gcctcccctc ccccagccgc ggcccccgcc tccccccgca ctgcaccctc

361 ggtgttggct gcagcccgcg agcagttccc gtcaatccct ccccccttac acaggatgtc

421 catattagga catctgcgtc agcaggtttc cacggccttt ccctgtagcc ctggggggag

481 ccatccccga aacccctcat cttggggggc ccacgagacc tctgagacag gaactgcgaa

541 atgctcacga gattaggaca cgcgccaagg cgggggcagg gagctgcgag cgctggggac

601 gcagccgggc ggccgcagaa gcgcccaggc ccgcgcgcca cccctctggc gccaccgtgg

661 ttgagcccgt gacgtttaca ctcattcata aaacgcttgt tataaaagca gtggctgcgg

721 cgcctcgtac tccaaccgca tctgcagcga gcaactgaga agccaagact gagccggcgg

781 ccgcggcgca gcgaacgagc agtgaccgtg ctcctaccca gctctgcttc acagcgccca

841 cctgtctccg cccctcggcc cctcgcccgg ctttgcctaa ccgccacgat gatgttctcg

901 ggcttcaacg cagactacga ggcgtcatcc tcccgctgca gcagcgcgtc cccggccggg

961 gatagcctct cttactacca ctcacccgca gactccttct ccagcatggg ctcgcctgtc

1021 aacgcgcagg taaggctggc ttcccgtcgc cgcggggccg ggggcttggg gtcgcggagg

1081 aggagacacc gggcgggacg ctccagtaga tgagtagggg gctcccttgt gcctggaggg

1141 aggctgccgt ggccggagcg gtgccggctc gggggctcgg gacttgctct gagcgcacgc

1201 acgcttgcca tagtaagaat tggttccccc ttcgggaggc aggttcgttc tgagcaacct

1261 ctggtctgca ctccaggacg gatctctgac attagctgga gcagacgtgt cccaagcaca

1321 aactcgctaa ctagagcctg gcttcttcgg ggaggtggca gaaagcggca atcccccctc

1381 ccccggcagc ctggagcacg gaggagggat gagggaggag ggtgcagcgg gcgggtgtgt

1441 aaggcagttt cattgataaa aagcgagttc attctggaga ctccggagcg gcgcctgcgt

1501 cagcgcagac gtcagggata tttataacaa accccctttc aagcaagtga tgctgaaggg

1561 ataacgggaa cgcagcggca ggatggaaga gacaggcact gcgctgcgga atgcctggga

1621 ggaaaagggg gagacctttc atccaggatg agggacattt aagatgaaat gtccgtggca

1681 ggatcgtttc tcttcactgc tgcatgcggc actgggaact cgccccacct gtgtccggaa

1741 cctgctcgct cacgtcggct ttccccttct gttttgttct aggacttctg cacggacctg

1801 gccgtctcca gtgccaactt cattcccacg gtcactgcca tctcgaccag tccggacctg

1861 cagtggctgg tgcagcccgc cctcgtctcc tctgtggccc catcgcagac cagagcccct

1921 caccctttcg gagtccccgc cccctccgct ggggcttact ccagggctgg cgttgtgaag

1981 accatgacag gaggccgagc gcagagcatt ggcaggaggg gcaaggtgga acaggtgagg

2041 aactctagcg tactcttcct gggaatgtgg gggctgggtg ggaagcagcc ccggagatgc

2101 aggagcccag tacagaggat gaagccactg atggggctgg ctgcacatcc gtaactggga

2161 gccctggctc caagcccatt ccatcccaac tcagactctg agtctcaccc taagaagtac

2221 tctcatagtt tcttccctaa gtttcttacc gcatgctttc agactgggct cttctttgtt

2281 ctcttgctga ggatcttatt ttaaatgcaa gtcacaccta ttctgcaact gcaggtcaga EPI-109 827

2341 aatggtttca cagtggggtg ccaggaagca gggaagctgc aggagccagt tctactgggg 2401 tgggtgaatg gaggtgatgg cagacacttt tactgaatgt cggtcttttt ttgtgattat 2461 tctagttatc tccagaagaa gaagagaaaa ggagaatccg aagggaaagg aataagatgg 2521 ctgcagccaa atgccgcaac cggaggaggg agctgactga tacactccaa gcggtaggta 2581 ctctgtgggt tgctcctttt taaaacttaa gggaaagttg gagattgagc ataagggccc 2641 ttgagtaaga ctgtgtctta tgctttcctt tatccctctg tatacaggag acagaccaac 2701 tagaagatga gaagtctgct ttgcagaccg agattgccaa cctgctgaag gagaaggaaa 2761 aactagagtt catcctggca gctcaccgac ctgcctgcaa gatccctgat gacctgggct 2821 tcccagaaga gatgtctgtg gcttcccttg atctgactgg gggcctgcca gaggttgcca 2881 ccccggagtc tgaggaggcc ttcaccctgc ctctcctcaa tgaccctgag cccaagccct 2941 cagtggaacc tgtcaagagc atcagcagca tggagctgaa gaccgagccc tttgatgact 3001 tcctgttccc agcatcatcc aggcccagtg gctctgagac agcccgctcc gtgccagaca 3061 tggacctatc tgggtccttc tatgcagcag actgggagcc tctgcacagt ggctccctgg 3121 ggatggggcc catggccaca gagctggagc ccctgtgcac tccggtggtc acctgtactc 3181 ccagctgcac tgcttacacg tcttccttcg tcttcaccta ccccgaggct gactccttcc 3241 ccagctgtgc agctgcccac cgcaagggca gcagcagcaa tgagccttcc tctgactcgc 3301 tcagctcacc cacgctgctg gccctgtgag ggggcaggga aggggaggca gccggcaccc 3361 acaagtgcca ctgcccgagc tggtgcatta cagagaggag aaacacatct tccctagagg 3421 gttcctgtag acctagggag gaccttatct gtgcgtgaaa cacaccaggc tgtgggcctc 3481 aaggacttga aagcatccat gtgtggactc aagtccttac ctcttccgga gatgtagcaa 3541 aacgcatgga gtgtgtattg ttcccagtga cacttcagag agctggtagt tagtagcatg 3601 ttgagccagg cctgggtctg tgtctctttt ctctttctcc ttagtcttct catagcatta 3661 actaatctat tgggttcat^'t attggaatta acctggtgct ggatattttc aaattgtatc 3721 tagtgcagct gattttaaca ataactactg tgttcctggc aatagtgtgt tctgattaga 3781 aatgaccaat attatactaa gaaaagatac gactttattt tctggtagat agaaataaat 3841 agctatatcc atgtactgta gtttttcttc aacatcaatg ttcattgtaa tgttactgat 3901 catgcattgt tgaggtggtc tgaatgttct gacattaaca gttttccatg aaaacgtttt 3961 attgtgtttt taatttattt attaagatgg attctcagat atttatattt ttattttatt 4021 tttttctacc ttgaggtctt ttgacatgtg gaaagtgaat ttgaatgaaa aatttaagca 4081 ttgtttgctt attgttccaa gacattgtca ataaaagcat ttaagttgaa tgcgaccaac 4141 cttgtgctct tttcattctg gaagtcttgt aagtttctga aaggtattat tggagaccag 4201 tttgtcaaga agggtagctg ctggaggggg acacaccctc tgtctgatcc cttatcaaag 4261 aggacaagga aactatagag ctgattttag aatattttac aaatacatgc cttccattgg 4321 aatgctaaga ttttctactg cttctgggga cgggaaaccg ctgtgtaaca gcttttgtgg 4381 gaatacattt tttctgtttc agtactcgca gggggaaata tttaaatttt gttgtgctaa 4441 tattaaattc agatgttttg atcttaaagg aaccctttaa gcaaacagaa cctagctttg 4501 tacagactat tttaactttt tattctcaca aaatcacgtg gagggttatt ctacttcaaa 4561 gatgagcaaa ttgaagaatg gttagaataa acaactttct tgatattccg ttatcggcat 4621 tagaatcttc ctgctcgtta tcgtatccag caggctgaac tgcctcttga tacttggtta 4681 aaaaaaattt tcaggccggg cgcggtggcc catgcctgta atcctagcac tttgggaggc 4741 cgaggcaggc ggatcacctg aggtcgggag ttcgagacca gcctgaccaa catggagaaa 4801 ccccgtcttt actaaaaata caaaattagc ctggtgtggt ggtgcatgcc tgtaatccta 4861 gctacttgag aggctgagac aggaaaatca cttgaactcg ggaggcggat gttgcagcga 4921 actgagattg cgccattgca ctccagcctg ggcaacaaga ttgaaactct gtttaaaaaa 4981 aaaagttttc actaatgtgt acattttttt gtactctttt attctcgaaa gggaaggagg 5041 gctattgccc tatcccttat taataaatgc attgtggttt ctggtttctc taataccata 5101 tgcccttcat tcagtttata gtgggcggaa gtgggggaga aaaagttgct cagaaatcaa 5161 aagatatctc aaacagcaca aataatggct gatcgttctg caaacaaaaa gttacataat 5221 agctcaagaa ggagaagtca acatgactct gaacaagctt taacttagaa actttatcat 5281 cttaaggaag aacgtgacct ttgtccagga cgtctctggt aatggggcac ttacacacac 5341 atgcacacgt acaaaccaca gggaaaggag accgcccttc tgcctctgct cgcgagtatc 5401 acgcaggcac catgcactat gttttcacac acactgggtg gaagaagagc ttcagcgcca 5461 gtcttctaat gctttggtga taatgaaaat cactgggtgc ttatggggtg tcatattcaa 5521 tcgagttaaa agttttaatt caaaatgaca gttttactga ggttgatgtt ctcgtctatg 5581 atatctctgc ccctcccata aaaatggaca tttaaaagca acttaccgct ctttagatca 5641 ctcctatatc acacaccact tggggtgctg tttctgctag acttgtgatg acagtggcct 5701 taggatccct gtttgctgtt caaagggcaa atattttata gcctttaaat atacctaaac 5761 taaatacaga attaatataa ctaacaaaca cctggtctga aataacaagg tgatctaccc 5821 tggaaggaac ccagctggtg ggccaggagc ggtggctcac acctgtaatt ccagcacttt 5881 gggaggctga gacaggagga tcactggagt ccaggagttt gagaccagcc tgggcaacat 5941 ggcaaaaccc agtgtgcttc tgttgtccca gctacactac tcaggaggct gaggcaggag 6001 tatgacttga gcctgggagg gggaggttgc agagaactga tattgcacca ccactgcact 6061 ccagcctggg tgacacagca aaaccctatc tcaaaaaaaa aaaaaaaaaa aaggaaccca 6121 gctggttcct gtaggtgtgc aataataaca accagaggaa gaaaaggaag acgatttccc 6181 agatgaagaa gggcagctgg accttcggac

(2) INFORMATION FOR SEQ ID NO: 2659:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs EPI-109 828

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2659 1 gcagccgggc ggccgcagaa gcgcccaggc ccgcgcgcca cccctctggc gccaccgtgg

61 ttgagcccgt gacgtttaca ctcattcata aaacgcttgt tataaaagca gtggctgcgg

121 cgcctcgtac tccaaccgca tctgcagcga gcaactgaga agccaagact gagccggcgg

181 ccgcggcgca gcgaacgagc agtgaccgtg ctcctaccca gctctgcttc acagcgccca

241 cctgtctccg cccctcggcc cctcgcccgg ctttgcctaa ccgccacgat gatgttctcg

301 ggcttcaacg cagactacga ggcgtcatcc tcccgctgca gcagcgcgtc cccggccggg

361 gatagcctct cttactacca ctcacccgca gactccttct ccagcatggg ctcgcctgtc

421 aacgcgcagg taaggctggc ttcccgtcgc cgcggggccg ggggcttggg gtcgcggagg

481 aggagacacc gggcgggacg ctccagtaga tgagtagggg gctcccttgt gcctggaggg

541 aggctgccgt ggccggagcg gtgccggctc gggggctcgg gacttgctct gagcgcacgc

601 acgcttgcca tagtaagaat tggttccccc ttcgggaggc aggttcgttc tgagcaacct

661 ctggtctgca ctccaggacg gatctctgac attagctgga gcagacgtgt cccaagcaca

721 aactcgctaa ctagagcctg gcttcttcgg ggaggtggca gaaagcggca atcccccctc

781 ccccggcagc ctggagcacg gaggagggat gagggaggag ggtgcagcgg gcgggtgtgt

841 aaggcagttt cattgataaa aagcgagttc attctggaga ctccggagcg gcgcctgcgt

901 cagcgcagac gtcagggata tttataacaa accccctttc aagcaagtga tgctgaaggg

961 ataacgggaa cgcagcggca ggatggaaga gacaggcact gcgctgcgga atgcctggga

1021 ggaaaagggg gagacctttc atccaggatg agggacattt aagatgaaat gtccgtggca

1081 ggatcgtttc tcttcactgc tgcatgcggc actgggaact cgccccacct gtgtccggaa

1141 cctgctcgct cacgtcggct ttccccttct gttttgttct aggacttctg cacggacctg

1201 gccgtctcca gtgccaactt cattcccacg gtcactgcca tctcgaccag tccggacctg

1261 cagtggctgg tgcagcccgc cctcgtctcc tctgtggccc catcgcagac cagagcccct

1321 caccctttcg gagtccccgc cccctccgct ggggcttact ccagggctgg cgttgtgaag

1381 accatgacag gaggccgagc gcagagcatt ggcaggaggg gcaaggtgga acaggtgagg

1441 aactctagcg tactcttcct gggaatgtgg gggctgggtg ggaagcagcc ccggagatgc

1501 aggagcccag tacagaggat gaagccactg atggggctgg ctgcacatcc gtaactggga

1561 gccctggctc caagcccatt ccatcccaac tcagactctg agtctcaccc taagaagtac

1621 tctcatagtt tcttccctaa gtttcttacc gcatgctttc agactgggct cttctttgtt

1681 ctcttgctga ggatcttatt ttaaatgcaa gtcacaccta ttctgcaact gcaggtcaga

1741 aatggtttca cagtggggtg ccaggaagca gggaagctgc aggagccagt tctactgggg

1801 tgggtgaatg gaggtgatgg cagacacttt tactgaatgt cggtcttttt ttgtgattat

1861 tctagttatc tccagaagaa gaagagaaaa ggagaatccg aagggaaagg aataagatgg

1921 ctgcagccaa atgccgcaac cggaggaggg agctgactga tacactccaa gcggtaggta

1981 ctctgtgggt tgctcctttt taaaacttaa gggaaagttg gagattgagc ataagggccc

2041 ttgagtaaga ctgtgtctta tgctttcctt tatccctctg tatacaggag acagaccaac

2101 tagaagatga gaagtctgct ttgcagaccg agattgccaa cctgctgaag gagaaggaaa

2161 aactagagtt catcctggca gctcaccgac ctgcctgcaa gatccctgat gacctgggct

2221 tcccagaaga gatgtctgtg gcttcccttg atctgactgg gggcctgcca gaggttgcca

2281 ccccggagtc tgaggaggcc ttcaccctgc ctctcctcaa tgaccctgag cccaagccct

2341 cagtggaacc tgtcaagagc atcagcagca tggagctgaa gaccgagccc tttgatgact

2401 tcctgttccc agcatcatcc aggcccagtg gctctgagac agcccgctcc gtgccagaca

2461 tggacctatc tgggtccttc tatgcagcag actgggagcc tctgcacagt ggctccctgg

2521 ggatggggcc catggccaca gagctggagc ccctgtgcac tccggtggtc acctgtactc

2581 ccagctgcac tgcttacacg tcttccttcg tcttcaccta ccccgaggct gactccttcc

2641 ccagctgtgc agctgcccac cgcaagggca gcagcagcaa tgagccttcc tctgactcgc

2701 tcagctcacc cacgctgctg gccctgtgag ggggcaggga aggggaggca gccggcaccc

2761 acaagtgcca ctgcccgagc tggtgcatta cagagaggag aaacacatct tccctagagg

2821 gttcctgtag acctagggag gaccttatct gtgcgtgaaa cacaccaggc tgtgggcctc

2881 aaggacttga aagcatccat gtgtggactc aagtccttac ctcttccgga gatgtagcaa

2941 aacgcatgga gtgtgtattg ttcccagtga cacttcagag agctggtagt tagtagcatg

3001 ttgagccagg cctgggtctg tgtctctttt ctctttctcc ttagtcttct catagcatta

3061 actaatctat tgggttcatt attggaatta acctggtgct ggatattttc aaattgtatc

3121 tagtgcagct gattttaaca ataactactg tgttcctggc aatagtgtgt tctgattaga

3181 aatgaccaat attatactaa gaaaagatac gactttattt tctggtagat agaaataaat

3241 agctatatcc atgtactgta gtttttcttc aacatcaatg ttcattgtaa tgttactgat

3301 catgcattgt tgaggtggtc tgaatgttct gacattaaca gttttccatg aaaacgtttt

3361 attgtgtttt taatttattt attaagatgg attctcagat atttatattt ttattttatt

3421 tttttctacc ttgaggtctt ttgacatgtg gaaagtgaat ttgaatgaaa aatttaagca

3481 ttgtttgctt attgttccaa gacattgtca ataaaagcat ttaagttgaa tgcgaccaac

3541 cttgtgctct tttcattctg gaagt

(2) INFORMATION FOR SEQ ID NO: 2660: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid EPI-109 829

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2660

1 cctcgaggtc gaagcttatt taaaagcata ttttccaatg cctgctttag ctgtggaaaa

61 ggaagactct ccgagggcaa atccaggagt catggaaaac aatgggcagg gcagcttggt

121 gctgtgactg gatgggtctt taaggttgtt tcccttgaat aaagaatgag ggaattccac

181 caggggaagg agagtagacc aaacatttgg tgaacagaaa gggagacaga gtctttagtg

241 ttattcccca aatattcctg gagagncctt tgagacacct ggtaggatta tagtgatcta

301 aagaggcatg gccatgtgac tgcttnggcc aatgatgtat gggcagaagt gatgtgtgcc

361 ataagtggat gctctgacag acatgatgtt ccgagttcct tccccacagn caggatagct 421 gtgaaaaggg gtatcaacac gaggcctcct tcagcctgag ccctttagtg actacaatga

481 gcagagctac cctgccaacc tacaacggtc atgtagnaga aatgaccaac tttcactgga 541 ataagncact gatatgttag ggttgnntgg tagggcagca taacactnnc tntcctgaca 601 gaactgggag tgagagataa ggctggagag agaaggagtt ggattgtgaa aanccccttc 661 tccaaggcat aggaatcgga actctcctga ttgtaaggaa aagccaatga aggcttccaa 721 gcaggggcgt taacatgaac agatttgtta tttttttgga tgaaatatgc tatttctcaa 781 cataaggaga agatcagcct actaaaccac atgaggcaga gaggaacaca cagaacctta 841 gccaaaagat atatatttat gcaaagtcct aagtcttgaa atttctaaat acaggagctc 901 tgaacggagt tacagtcaga ggatcaggca agaaaatttc ttctatgcca caagcgctat 961 ttcctctgca gataactaat actccacaag aaagtttgcc agagtagaga aaatacaaag

1021 gaatgtaaca cagacctgag gtcaatttcc agctgcctgt gtgacctcaa caaagatact

1081 taacctctct gggcctattt cctcacatgt taaatctgga taataatata tgtctctcaa

1141 gacagttgtg gggagaaaac agcgtattta aattgcttag gagaatgcct ggcagataat

1201 aagtgtttaa tacatgaaac tgatttttat tactgttatt aaaaaatatt tagaacacca

1261 actccctgaa tacaacagaa aatgattcag ggcaacagac agaggagaat gttctctcct

1321 tgaggaagca actggatctt gtcatcactg tatacctacc taccccaccc cctccccagc

1381 tcagtgcctg gctcacagta ggctttcagt taccctctgc agatcagtga aagctaggtg

1441 agtgcccgga gtgaagaaaa gttggcaggt ttcccactga taccagctgc tgttggtttc

1501 tgaacactca aagccgcaaa taccttaggg ctgggggcaa tgaacccaag gctgaattcc

1561 aagttcagaa gcagcgaagt ctgaatttag aacctaggac ttaaactgct gcaggtccaa

1621 cttcaagccc cagttttaga cagaggcttg ggaaagatct gacttctaac ccggttcccc

1681 ctcccctcct cccctcgatg cttctcacag gaaagtacac ctggtcctgc caaatcgcac

1741 tcttatatcc tggcatccta tccaggctct gcgaggatgg aaactgcgag gcaggggagg

1801 gaagcgggct gtttggccac cacctcccta gtgctgcagg cgaccctgtc acactaaact

1861 cctggcagcc cagtgaggtg gacggcaccg ccccacctgc agatgaggga aatgaagctc

1921 ggaggagttc cgtgatttgc ttgcttcaca ctgtggtagc ctggccacga aagaaccaag

1981 gattccgact tcggattctt ccaccacaca ctttcgtcct aagggtgggg gcggggggag

2041 aataaaataa ccgcggaaaa ggaaccactt acatgtgtct agcgcttcct agaggctacc

2101 caggatatgc gcccaccacc cggccggagt gcagagattt gaagtccagg ttctaccccg

2161 ggctccgagt actactgcgt gactttatgc gagtgtcgcc gccttctggg cttgttttcc

2221 cggaagcaac tcggcgcgga tggagtgtgt gtgtgcgcgc gcgcgttatg ttgtgcgtgt

2281 tgtgttagcg tgtgcgtgtt gtccgagttt cggatcgcct acacctgtga acccccgcgc

2341 cctttccccc acggtcccgg agatgaagtg gggtgcaacg gagactcagc tgagcgtcca

2401 gtttcgggca atacaaatct ctcggcttct acgagcagcc acacgacccc gcggaccgtc

2461 gctcctgaac ttgaccgaga tgcaaacttc ggagtgttct caacgtgggg gccgactctc

2521 ggagaccgcc ctaaacttaa gtccccttag gctcgcccca cctggacttc acatagccac

2581 cttaagggcg gtattcccgc ccccggaagt gcgggtggca gcgtacttgg attctcagcc

2641 tccagccccg cgcggtggcg gccgcggtgg atgacttcgg gccccacaag tggaaacaac

2701 aaccacccct cgcccgcacc cctggcccaa aacaactggc caggttccct cgtcccgggt

2761 ccctgcatcc cccgcatccc cgtccgcagc cgtgaacttg agcccccctc catcagaggt

2821 tgcgagcgtc gccgctcggc agccaccgtc actagacagt caaaccccaa gacgtcagcc

2881 cacaatgcac cgggcgggcc gggaaaaacg gcccggggag gggaccgggg aacagagggc

2941 cgagaggcgt gcggcagggg ggagggtagg agaaagaagg gcccgactgt aggagggcag

3001 cggagcatta cctcatcccg tgagcctccg .cgggcccaga gaagaatctt ctagggtgga

3061 gtctccatgg tgacgggcgg gcccgccccc ctgagagcga cgcgagccaa tgggaaggcc

3121 ttggggtgac atcatgggct atttttaggg gttgactggt agcagataag tgttgagctc

3181 gggctggata agggctca

(2) INFORMATION FOR SEQ ID NO: 2661:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2661

1 cccggggagg ggaccgggga acagagggcc gagaggcgtg cggcaggggg gagggtagga

61 gaaagaaggg cccgactgta ggagggcagc ggagcattac ctcatcccgt gagcctccgc

121 gggcccagag aagaatcttc tagggtggag tctccatggt gacgggcggg cccgcccccc

181 tgagagcgac gcgagccaat gggaaggcct tggggtgaca tcatgggcta tttttagggg EPI-109 830

241 ttgactggta gcagataagt gttgagctcg ggctggataa gggctcagag ttgcactgag

301 tgtggctgaa gcagcgaggc gggagtggag gtgcgcggag tcaggcagac agacagacac

361 agccagccag ccaggtcggc agtatagtcc gaactgcaaa tcttattttc ttttcacctt

421 ctctctaact gcccagagct agcgcctgtg gctcccgggc tggtggttcg ggagtgtcca

481 gagagccttg tctccagccg gccccgggag gagagccctg ctgcccaggc gctgttgaca

541 gcggcggaaa gcagcggtac cccacgcgcc cgccggggga cgtcggcgag cggctgcagc

601 agcaaagaac tttcccggcg gggaggaccg gagacaagtg gcagagtccc ggagcgaact

661 tttgcaagcc tttcctgcgt cttaggcttc tccacggcgg taaagaccag aaggcggcgg

721 agagccacgc aagagaagaa ggacgtgcgc tcagcttcgc tcgcaccggt tgttgaactt

781 gggcgagcgc gagccgcggc tgccgggcgc cccctccccc tagcagcgga ggaggggaca

841 agtcgtcgga gtccgggcgg ccaagacccg ccgccggccg gccactgcag ggtccgcact

901 gatccgctcc gcggggagag ccgctgctct gggaagtgag ttcgcctgcg gactccgagg

961 aaccgctgcg cccgaagagc gctcagtgag tgaccgcgac ttttcaaagc cgggtagcgc

1021 gcgcgagtcg acaagtaaga gtgcgggagg catcttaatt aaccctgcgc tccctggagc

1081 gagctggtga ggagggcgca gcggggacga cagccagcgg gtgcgtgcgc tcttagagaa

1141 actttccctg tcaaaggctc cggggggcgc gggtgtcccc cgcttgccag agccctgttg

1201 cggccccgaa acttgtgcgc gcacgccaaa ctaacctcac gtgaagtgac ggactgttct

1261 atgactgcaa agatggaaac gaccttctat gacgatgccc tcaacgcctc gttcctcccg

1321 tccgagagcg gaccttatgg ctacagtaac cccaagatcc tgaaacagag catgaccctg

1381 aacctggccg acccagtggg gagcctgaag ccgcacctcc gcgccaagaa ctcggacctc

1441 ctcacctcgc ccgacgtggg gctgctcaag ctggcgtcgc ccgagctgga gcgcctgata

1501 atccagtcca gcaacgggca catcaccacc acgccgaccc ccacccagtt cctgtgcccc

1561 aagaacgtga cagatgagca ggaggggttc gccgagggct tcgtgcgcgc cctggccgaa

1621 ctgcacagcc agaacacgct gcccagcgtc acgtcggcgg cgcagccggt caacggggca

1681 ggcatggtgg ctcccgcggt agcctcggtg gcagggggca gcggcagcgg cggcttcagc

1741 gccagcctgc acagcgagcc gccggtctac gcaaacctca gcaacttcaa cccaggcgcg

1801 ctgagcagcg gcggcggggc gccctcctac ggcgcggccg gcctggcctt tcccgcgcaa

1861 ccccagcagc agcagcagcc gccgcaccac ctgccccagc agatgcccgt gcagcacccg

1921 cggctgcagg ccctgaagga ggagcctcag acagtgcccg agatgcccgg cgagacaccg

1981 cccctgtccc ccatcgacat ggagtcccag gagcggatca aggcggagag gaagcgcatg

2041 aggaaccgca tcgctgcctc caagtgccga aaaaggaagc tggagagaat cgcccggctg

2101 gaggaaaaag tgaaaacctt gaaagctcag aactcggagc tggcgtccac ggccaacatg

2161 ctcagggaac aggtggcaca gcttaaacag aaagtcatga accacgttaa cagtgggtgc

2221 caactcatgc taacgcagca gttgcaaaca ttttgaagag agaccgtcgg gggctgaggg

2281 gcaacgaaga aaaaaaataa cacagagaga cagacttgag aacttgacaa gttgcgacgg

2341 agagaaaaaa gaagtgtccg agaactaaag ccaagggtat ccaagttgga ctgggttcgg

2401 tctgacggcg cccccagtgt gcacgagtgg gaaggacttg gtcgcgccct cccttggcgt

2461 ggagccaggg agcggccgcc tgcgggctgc cccgctttgc ggacgggctg tccccgcgcg

2521 aacggaacgt tggactttcg ttaacattga ccaagaactg catggaccta acattcgatc

2581 tcattcagta ttaaaggggg gagggggagg gggttacaaa ctgcaataga gactgtagat

2641 tgcttctgta gtactcctta agaacacaaa gcggggggag ggttggggag gggcggcagg

2701 agggaggttt gtgagagcga ggctgagcct acagatgaac tctttctggc ctgctttcgt

2761 taactgtgta tgtacatata tatatttttt aatttgatta aagctgatta ctgtcaataa

2821 acagcttcat gcctttgtaa gttatttctt gtttgtttgt ttgggtatcc tgcccagtgt

2881 tgtttgtaaa taagagattt ggagcactct gagtttacca tttgtaataa agtatataat

2941 ttttttatgt tttgtttctg aaaattccag aaaggatatt taagaaaata caataaacta

3001 ttggaaagta ctcccctaac ctcttttctg catcatctgt agatcctagt ctatctaggt

3061 ggagttgaaa gagttaagaa tgctcgataa aatcactctc agtgcttctt actattaagc

3121 agtaaaaact gttctctatt agacttagaa ataaatgtac ctgatgtacc tgatgctatg

3181 tcaggcttca tactccacgc tcccccagcg tatctatatg gaattgctta ccaaaggcta

3241 gtgcgatgtt tcaggaggct ggaggaaggg gggttgcagt ggagagggac agcccactga

3301 gaagtcaaac atttcaaagt ttggattgca tcaagtggca tgtgctgtga ccatttataa

3361 tgttagaaat tttacaatag gtgcttattc tcaaagcagg aattggtggc agattttaca

3421 aaagatgtat ccttccaatt tggaatcttc tctttgacaa ttcctagata aaaagatggc

3481 ctttgtctta tgaatattta taacagcatt ctgtcacaat aaatgtattc aaataccaat

3541 aacagatctt gaattgcttc cctttactac ttttttgttc ccaagttata tactgaagtt

3601 tttattttta gttgctgagg tt

(2) INFORMATION FOR SEQ ID NO:2662: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2662

1 gcaggaacag tgctagtatt gctcgagccc gagggctgga ggttagggga tgaaggtctg 61 cttccacgct ttgcactgaa ttagggctag aattggggat gggggtaggg gcgcattcct 121 tcgggagccg aggcttaagt cctcggggtc ctgtactcga tgccgtttct cctatctctg 181 agcctcagaa ctgtcttcag tttccgtaca agggtaaaaa ggcgctctct gccccatccc EPI-109 831

241 ccccgacctc gggaacaagg gtccgcattg aaccaggtgc gaatgttctc tctcattctg 301 cgccgttccc gcctcccctc ccccagccgc ggcccccgcc tccccccgca ctgcaccctc 361 ggtgttggct gcagcccgcg agcagttccc gtcaatccct ccccccttac acaggatgtc 421 catattagga catctgcgtc agcaggtttc cacggccttt ccctgtagcc ctggggggag 481 ccatccccga aacccctcat cttggggggc ccacgagacc tctgagacag gaactgcgaa 541 atgctcacga gattaggaca cgcgccaagg cgggggcagg gagctgcgag cgctggggac 601 gcagccgggc ggccgcagaa gcgcccaggc ccgcgcgcca cccctctggc gccaccgtgg 661 ttgagcccgt gacgtttaca ctcattcata aaacgcttgt tataaaagca gtggctgcgg 721 cgcctcgtac tccaaccgca tctgcagcga gcaactgaga agccaagact gagccggcgg 781 ccgcggcgca gcgaacgagc agtgaccgtg ctcctaccca gctctgcttc acagcgccca 841 cctgtctccg cccctcggcc cctcgcccgg ctttgcctaa ccgccacgat gatgttctcg gθl ggcttcaacg cagactacga ggcgtcatcc tcccgctgca gcagcgcgtc cccggccggg 961 gatagcctct cttactacca ctcacccgca gactccttct ccagcatggg ctcgcctgtc 1021 aacgcgcagg taaggctggc ttcccgtcgc cgcggggccg ggggcttggg gtcgcggagg 1081 aggagacacc gggcgggacg ctccagtaga tgagtagggg gctcccttgt gcctggaggg 1141 aggctgccgt ggccggagcg gtgccggctc gggggctcgg gacttgctct gagcgcacgc 1201 acgcttgcca tagtaagaat tggttccccc ttcgggaggc aggttcgttc tgagcaacct 1261 ctggtctgca ctccaggacg gatctctgac attagctgga gcagacgtgt cccaagcaca 1321 aactcgctaa ctagagcctg gcttcttcgg ggaggtggca gaaagcggca atcccccctc 1381 ccccggcagc ctggagcacg gaggagggat gagggaggag ggtgcagcgg gcgggtgtgt 1441 aaggcagttt cattgataaa aagcgagttc attctggaga ctccggagcg gcgcctgcgt 1501 cagcgcagac gtcagggata tttataacaa accccctttc aagcaagtga tgctgaaggg 1561 ataacgggaa cgcagcggca ggatggaaga gacaggcact gcgctgcgga atgcctggga 1621 ggaaaagggg gagacctttc atccaggatg agggacattt aagatgaaat gtccgtggca 1681 ggatcgtttc tcttcactgc tgcatgcggc actgggaact cgccccacct gtgtccggaa 1741 cctgctcgct cacgtcggct ttccccttct gttttgttct aggacttctg cacggacctg 1801 gccgtctcca gtgccaactt cattcccacg gtcactgcca tctcgaccag tccggacctg 1861 cagtggctgg tgcagcccgc cctcgtctcc tctgtggccc catcgcagac cagagcccct 1921 caccctttcg gagtccccgc cccctccgct ggggcttact ccagggctgg cgttgtgaag 1981 accatgacag gaggccgagc gcagagcatt ggcaggaggg gcaaggtgga acaggtgagg 2041 aactctagcg tactcttcct gggaatgtgg gggctgggtg ggaagcagcc ccggagatgc 2101 aggagcccag tacagaggat gaagccactg atggggctgg ctgcacatcc gtaactggga 2161 gccctggctc caagcccatt ccatcccaac tcagactctg agtctcaccc taagaagtac 2221 tctcatagtt tcttccctaa gtttcttacc gcatgctttc agactgggct cttctttgtt 2281 ctcttgctga ggatcttatt ttaaatgcaa gtcacaccta ttctgcaact gcaggtcaga 2341 aatggtttca cagtggggtg ccaggaagca gggaagctgc aggagccagt tctactgggg 2401 tgggtgaatg gaggtgatgg cagacacttt tactgaatgt cggtcttttt ttgtgattat 2461 tctagttatc tccagaagaa gaagagaaaa ggagaatccg aagggaaagg aataagatgg 2521 ctgcagccaa atgccgcaac cggaggaggg agctgactga tacactccaa gcggtaggta 2581 ctctgtgggt tgctcctttt taaaacttaa gggaaagttg gagattgagc ataagggccc 2641 ttgagtaaga ctgtgtctta tgctttcctt tatccctctg tatacaggag acagaccaac 2701 tagaagatga gaagtctgct ttgcagaccg agattgccaa cctgctgaag gagaaggaaa 2761 aactagagtt catcctggca gctcaccgac ctgcctgcaa gatccctgat gacctgggct 2821 tcccagaaga gatgtctgtg gcttcccttg atctgactgg gggcctgcca gaggttgcca 2881 ccccggagtc tgaggaggcc ttcaccctgc ctctcctcaa tgaccctgag cccaagccct 2941 cagtggaacc tgtcaagagc atcagcagca tggagctgaa gaccgagccc tttgatgact 3001 tcctgttccc agcatcatcc aggcccagtg gctctgagac agcccgctcc gtgccagaca 3061 tggacctatc tgggtccttc tatgcagcag actgggagcc tctgcacagt ggctccctgg 3121 ggatggggcc catggccaca gagctggagc ccctgtgcac tccggtggtc acctgtactc 3181 ccagctgcac tgcttacacg tcttccttcg tcttcaccta ccccgaggct gactccttcc 3241 ccagctgtgc agctgcccac cgcaagggca gcagcagcaa tgagccttcc tctgactcgc 3301 tcagctcacc cacgctgctg gccctgtgag ggggcaggga aggggaggca gccggcaccc 3361 acaagtgcca ctgcccgagc tggtgcatta cagagaggag aaacacatct tccctagagg 3421 gttcctgtag acctagggag gaccttatct gtgcgtgaaa cacaccaggc tgtgggcctc 3481 aaggacttga aagcatccat gtgtggactc aagtccttac ctcttccgga gatgtagcaa 3541 aacgcatgga gtgtgtattg ttcccagtga cacttcagag agctggtagt tagtagcatg 3601 ttgagccagg cctgggtctg tgtctctttt ctctttctcc ttagtcttct catagcatta 3661 actaatctat tgggttcatt attggaatta acctggtgct ggatattttc aaattgtatc 3721 tagtgcagct gattttaaca ataactactg tgttcctggc aatagtgtgt tctgattaga 3781 aatgaccaat attatactaa gaaaagatac gactttattt tctggtagat agaaataaat 3841 agctatatcc atgtactgta gtttttcttc aacatcaatg ttcattgtaa tgttactgat 3901 catgcattgt tgaggtggtc tgaatgttct gacattaaca gttttccatg aaaacgtttt 3961 attgtgtttt taatttattt attaagatgg attctcagat atttatattt ttattttatt 4021 tttttctacc ttgaggtctt ttgacatgtg gaaagtgaat ttgaatgaaa aatttaagca 4081 ttgtttgctt attgttccaa gacattgtca ataaaagcat ttaagttgaa tgcgaccaac 4141 cttgtgctct tttcattctg gaagtcttgt aagtttctga aaggtattat tggagaccag 4201 tttgtcaaga agggtagctg ctggaggggg acacaccctc tgtctgatcc cttatcaaag 4261 aggacaagga aactatagag ctgattttag aatattttac aaatacatgc cttccattgg EPI-109 832

4321 aatgctaaga ttttctactg cttctgggga cgggaaaccg ctgtgtaaca gcttttgtgg

4381 gaatacattt tttctgtttc agtactcgca gggggaaata tttaaatttt gttgtgctaa

4441 tattaaattc agatgttttg atcttaaagg aaccctttaa gcaaacagaa cctagctttg

4501 tacagactat tttaactttt tattctcaca aaatcacgtg gagggttatt ctacttcaaa

4561 gatgagcaaa ttgaagaatg gttagaataa acaactttct tgatattccg ttatcggcat

4621 tagaatcttc ctgctcgtta tcgtatccag caggctgaac tgcctcttga tacttggtta

4681 aaaaaaattt tcaggccggg cgcggtggcc catgcctgta atcctagcac tttgggaggc

4741 cgaggcaggc ggatcacctg aggtcgggag ttcgagacca gcctgaccaa catggagaaa

4801 ccccgtcttt actaaaaata caaaattagc ctggtgtggt ggtgcatgcc tgtaatccta

4861 gctacttgag aggctgagac aggaaaatca cttgaactcg ggaggcggat gttgcagcga

4921 actgagattg cgccattgca ctccagcctg ggcaacaaga ttgaaactct gtttaaaaaa

4981 aaaagttttc actaatgtgt acattttttt gtactctttt attctcgaaa gggaaggagg

5041 gctattgccc tatcccttat taataaatgc attgtggttt ctggtttctc taataccata

5101 tgcccttcat tcagtttata gtgggcggaa gtgggggaga aaaagttgct cagaaatcaa

5161 aagatatctc aaacagcaca aataatggct gatcgttctg caaacaaaaa gttacataat

5221 agctcaagaa ggagaagtca acatgactct gaacaagctt taacttagaa actttatcat

5281 cttaaggaag aacgtgacct ttgtccagga cgtctctggt aatggggcac ttacacacac

5341 atgcacacgt acaaaccaca gggaaaggag accgcccttc tgcctctgct cgcgagtatc

5401 acgcaggcac catgcactat gttttcacac acactgggtg gaagaagagc ttcagcgcca

5461 gtcttctaat gctttggtga taatgaaaat cactgggtgc ttatggggtg tcatattcaa

5521 tcgagttaaa agttttaatt caaaatgaca gttttactga ggttgatgtt ctcgtctatg

5581 atatctctgc ccctcccata aaaatggaca tttaaaagca acttaccgct ctttagatca

5641 ctcctatatc acacaccact tggggtgctg tttctgctag acttgtgatg acagtggcct

5701 taggatccct gtttgctgtt caaagggcaa atattttata gcctttaaat atacctaaac

5761 taaatacaga attaatataa ctaacaaaca cctggtctga aataacaagg tgatctaccc

5821 tggaaggaac ccagctggtg ggccaggagc ggtggctcac acctgtaatt ccagcacttt

5881 gggaggctga gacaggagga tcactggagt ccaggagttt gagaccagcc tgggcaacat

5941 ggcaaaaccc agtgtgcttc tgttgtccca gctacactac tcaggaggct gaggcaggag

6001 tatgacttga gcctgggagg gggaggttgc agagaactga tattgcacca ccactgcact

6061 ccagcctggg tgacacagca aaaccctatc tcaaaaaaaa aaaaaaaaaa aaggaaccca

6121 gctggttcct gtaggtgtgc aataataaca accagaggaa gaaaaggaag acgatttccc

6181 agatgaagaa gggcagctgg accttcggac

1 gcagccgggc ggccgcagaa gcgcccaggc ccgcgcgcca cccctctggc gccaccgtgg

61 ttgagcccgt gacgtttaca ctcattcata aaacgcttgt tataaaagca gtggctgcgg

121 cgcctcgtac tccaaccgca tctgcagcga gcaactgaga agccaagact gagccggcgg

181 ccgcggcgca gcgaacgagc agtgaccgtg ctcctaccca gctctgcttc acagcgccca

241 cctgtctccg cccctcggcc cctcgcccgg ctttgcctaa ccgccacgat gatgttctcg

301 ggcttcaacg cagactacga ggcgtcatcc tcccgctgca gcagcgcgtc cccggccggg

361 gatagcctct cttactacca ctcacccgca gactccttct ccagcatggg ctcgcctgtc

421 aacgcgcagg taaggctggc ttcccgtcgc cgcggggccg ggggcttggg gtcgcggagg

481 aggagacacc gggcgggacg ctccagtaga tgagtagggg gctcccttgt gcctggaggg

541 aggctgccgt ggccggagcg gtgccggctc gggggctcgg gacttgctct gagcgcacgc

601 acgcttgcca tagtaagaat tggttccccc ttcgggaggc aggttcgttc tgagcaacct

661 ctggtctgca ctccaggacg gatctctgac attagctgga gcagacgtgt cccaagcaca

721 aactcgctaa ctagagcctg gcttcttcgg ggaggtggca gaaagcggca atcccccctc

781 ccccggcagc ctggagcacg gaggagggat gagggaggag ggtgcagcgg gcgggtgtgt

841 aaggcagttt cattgataaa aagcgagttc attctggaga ctccggagcg gcgcctgcgt

901 cagcgcagac gtcagggata tttataacaa accccctttc aagcaagtga tgctgaaggg

961 ataacgggaa cgcagcggca ggatggaaga gacaggcact gcgctgcgga atgcctggga

1021 ggaaaagggg gagacctttc atccaggatg agggacattt aagatgaaat gtccgtggca

1081 ggatcgtttc tcttcactgc tgcatgcggc actgggaact cgccccacct gtgtccggaa

1141 cctgctcgct cacgtcggct ttccccttct gttttgttct aggacttctg cacggacctg

1201 gccgtctcca gtgccaactt cattcccacg gtcactgcca tctcgaccag tccggacctg

1261 cagtggctgg tgcagcccgc cctcgtctcc tctgtggccc catcgcagac cagagcccct

1321 caccctttcg gagtccccgc cccctccgct ggggcttact ccagggctgg cgttgtgaag

1381 accatgacag gaggccgagc gcagagcatt ggcaggaggg gcaaggtgga acaggtgagg

1441 aactctagcg tactcttcct gggaatgtgg gggctgggtg ggaagcagcc ccggagatgc

1501 aggagcccag tacagaggat gaagccactg atggggctgg ctgcacatcc gtaactggga

1561 gccctggctc caagcccatt ccatcccaac tcagactctg agtctcaccc taagaagtac

1621 tctcatagtt tcttccctaa gtttcttacc gcatgctttc agactgggct cttctttgtt

1681 ctcttgctga ggatcttatt ttaaatgcaa gtcacaccta ttctgcaact gcaggtcaga

1741 aatggtttca cagtggggtg ccaggaagca gggaagctgc aggagccagt tctactgggg

1801 tgggtgaatg gaggtgatgg cagacacttt tactgaatgt cggtcttttt ttgtgattat

1861 tctagttatc tccagaagaa gaagagaaaa ggagaatccg aagggaaagg aataagatgg

1921 ctgcagccaa atgccgcaac cggaggaggg agctgactga tacactccaa gcggtaggta

1981 ctctgtgggt tgctcctttt taaaacttaa gggaaagttg gagattgagc ataagggccc

2041 ttgagtaaga ctgtgtctta tgctttcctt tatccctctg tatacaggag acagaccaac

2101 tagaagatga gaagtctgct ttgcagaccg agattgccaa cctgctgaag gagaaggaaa EPI-109 833

2161 aactagagtt catcctggca gctcaccgac ctgcctgcaa gatccctgat gacctgggct 2221 tcccagaaga gatgtctgtg gcttcccttg atctgactgg gggcctgcca gaggttgcca 2281 ccccggagtc tgaggaggcc ttcaccctgc ctctcctcaa tgaccctgag cccaagccct 2341 cagtggaacc tgtcaagagc atcagcagca tggagctgaa gaccgagccc tttgatgact 2401 tcctgttccc agcatcatcc aggcccagtg gctctgagac agcccgctcc gtgccagaca 2461 tggacctatc tgggtccttc tatgcagcag actgggagcc tctgcacagt ggctccctgg 2521 ggatggggcc catggccaca gagctggagc ccctgtgcac tccggtggtc acctgtactc 2581 ccagctgcac tgcttacacg tcttccttcg tcttcaccta ccccgaggct gactccttcc 2641 ccagctgtgc agctgcccac cgcaagggca gcagcagcaa tgagccttcc tctgactcgc 2701 tcagctcacc cacgctgctg gccctgtgag ggggcaggga aggggaggca gccggcaccc 2761 acaagtgcca ctgcccgagc tggtgcatta cagagaggag aaacacatct tccctagagg 2821 gttcctgtag acctagggag gaccttatct gtgcgtgaaa cacaccaggc tgtgggcctc 2881 aaggacttga aagcatccat gtgtggactc aagtccttac ctcttccgga gatgtagcaa 2941 aacgcatgga gtgtgtattg ttcccagtga cacttcagag agctggtagt tagtagcatg 3001 ttgagccagg cctgggtctg tgtctctttt ctctttctcc ttagtcttct catagcatta 3061 actaatctat tgggttcatt attggaatta acctggtgct ggatattttc aaattgtatc 3121 tagtgcagct gattttaaca ataactactg tgttcctggc aatagtgtgt tctgattaga 3181 aatgaccaat attatactaa gaaaagatac gactttattt tctggtagat agaaataaat 3241 agctatatcc atgtactgta gtttttcttc aacatcaatg ttcattgtaa tgttactgat 3301 catgcattgt tgaggtggtc tgaatgttct gacattaaca gttttccatg aaaacgtttt 3361 attgtgtttt taatttattt attaagatgg attctcagat atttatattt ttattttatt 3421 tttttctacc ttgaggtctt ttgacatgtg gaaagtgaat ttgaatgaaa aatttaagca 3481 ttgtttgctt attgttccaa gacattgtca ataaaagcat ttaagttgaa tgcgaccaac 3541 cttgtgctct tttcattctg gaagt

1 cctcgaggtc gaagcttatt taaaagcata ttttccaatg cctgctttag ctgtggaaaa

61 ggaagactct ccgagggcaa atccaggagt catggaaaac aatgggcagg gcagcttggt

121 gctgtgactg gatgggtctt taaggttgtt tcccttgaat aaagaatgag ggaattccac

181 caggggaagg agagtagacc aaacatttgg tgaacagaaa gggagacaga gtctttagtg

241 ttattcccca aatattcctg gagagncctt tgagacacct ggtaggatta tagtgatcta

301 aagaggcatg gccatgtgac tgcttnggcc aatgatgtat gggcagaagt gatgtgtgcc

361 ataagtggat gctctgacag acatgatgtt ccgagttcct tccccacagn caggatagct

421 gtgaaaaggg gtatcaacac gaggcctcct tcagcctgag ccctttagtg actacaatga

481 gcagagctac cctgccaacc tacaacggtc atgtagnaga aatgaccaac tttcactgga

541 ataagncact gatatgttag ggttgnntgg tagggcagca taacactnnc tntcctgaca

601 gaactgggag tgagagataa ggctggagag agaaggagtt ggattgtgaa aanccccttc

661 tccaaggcat aggaatcgga actctcctga ttgtaaggaa aagccaatga aggcttccaa

721 gcaggggcgt taacatgaac agatttgtta tttttttgga tgaaatatgc tatttctcaa

781 cataaggaga agatcagcct actaaaccac atgaggcaga gaggaacaca cagaacctta

841 gccaaaagat atatatttat gcaaagtcct aagtcttgaa atttctaaat acaggagctc

901 tgaacggagt tacagtcaga ggatcaggca agaaaatttc ttctatgcca caagcgctat

961 ttcctctgca gataactaat actccacaag aaagtttgcc agagtagaga aaatacaaag

1021 gaatgtaaca cagacctgag gtcaatttcc agctgcctgt gtgacctcaa caaagatact

1081 taacctctct gggcctattt cctcacatgt taaatctgga taataatata tgtctctcaa

1141 gacagttgtg gggagaaaac agcgtattta aattgcttag gagaatgcct ggcagataat

1201 aagtgtttaa tacatgaaac tgatttttat tactgttatt aaaaaatatt tagaacacca

1261 actccctgaa tacaacagaa aatgattcag ggcaacagac agaggagaat gttctctcct

1321 tgaggaagca actggatctt gtcatcactg tatacctacc taccccaccc cctccccagc

1381 tcagtgcctg gctcacagta ggctttcagt taccctctgc agatcagtga aagctaggtg

1441 agtgcccgga gtgaagaaaa gttggcaggt ttcccactga taccagctgc tgttggtttc

1501 tgaacactca aagccgcaaa taccttaggg ctgggggcaa tgaacccaag gctgaattcc

1561 aagttcagaa gcagcgaagt ctgaatttag aacctaggac ttaaactgct gcaggtccaa

1621 cttcaagccc cagttttaga cagaggcttg ggaaagatct gacttctaac ccggttcccc

1681 ctcccctcct cccctcgatg cttctcacag gaaagtacac ctggtcctgc caaatcgcac

1741 tcttatatcc tggcatccta tccaggctct gcgaggatgg aaactgcgag gcaggggagg

1801 gaagcgggct gtttggccac cacctcccta gtgctgcagg cgaccctgtc acactaaact

1861 cctggcagcc cagtgaggtg gacggcaccg ccccacctgc agatgaggga aatgaagctc

1921 ggaggagttc cgtgatttgc ttgcttcaca ctgtggtagc ctggccacga aagaaccaag

1981 gattccgact tcggattctt ccaccacaca ctttcgtcct aagggtgggg gcggggggag

2041 aataaaataa ccgcggaaaa ggaaccactt acatgtgtct agcgcttcct agaggctacc

2101 caggatatgc gcccaccacc cggccggagt gcagagattt gaagtccagg ttctaccccg

2161 ggctccgagt actactgcgt gactttatgc gagtgtcgcc gccttctggg cttgttttcc

2221 cggaagcaac tcggcgcgga tggagtgtgt gtgtgcgcgc gcgcgttatg ttgtgcgtgt

2281 tgtgttagcg tgtgcgtgtt gtccgagttt cggatcgcct acacctgtga acccccgcgc

2341 cctttccccc acggtcccgg agatgaagtg gggtgcaacg gagactcagc tgagcgtcca

2401 gtttcgggca atacaaatct ctcggcttct acgagcagcc acacgacccc gcggaccgtc

2461 gctcctgaac ttgaccgaga tgcaaacttc ggagtgttct caacgtgggg gccgactctc

2521 ggagaccgcc ctaaacttaa gtccccttag gctcgcccca cctggacttc acatagccac

2581 cttaagggcg gtattcccgc ccccggaagt gcgggtggca gcgtacttgg attctcagcc EPI-109 834

2641 tccagccccg cgcggtggcg gccgcggtgg atgacttcgg gccccacaag tggaaacaac

2701 aaccacccct cgcccgcacc cctggcccaa aacaactggc caggttccct cgtcccgggt

2761 ccctgcatcc cccgcatccc cgtccgcagc cgtgaacttg agcccccctc catcagaggt

2821 tgcgagcgtc gccgctcggc agccaccgtc actagacagt caaaccccaa gacgtcagcc

2881 cacaatgcac cgggcgggcc gggaaaaacg gcccggggag gggaccgggg aacagagggc

2941 cgagaggcgt gcggcagggg ggagggtagg agaaagaagg gcccgactgt aggagggcag

3001 cggagcatta cctcatcccg tgagcctccg cgggcccaga gaagaatctt ctagggtgga

3061 gtctccatgg tgacgggcgg gcccgccccc ctgagagcga cgcgagccaa tgggaaggcc

3121 ttggggtgac atcatgggct atttttaggg gttgactggt agcagataag tgttgagctc 3181 gggctggata agggctca

1 cccggggagg ggaccgggga acagagggcc gagaggcgtg cggcaggggg gagggtagga

61 gaaagaaggg cccgactgta ggagggcagc ggagcattac ctcatcccgt gagcctccgc

121 gggcccagag aagaatcttc tagggtggag tctccatggt gacgggcggg cccgcccccc

181 tgagagcgac gcgagccaat gggaaggcct tggggtgaca tcatgggcta tttttagggg

241 ttgactggta gcagataagt gttgagctcg ggctggataa gggctcagag ttgcactgag

301 tgtggctgaa gcagcgaggc gggagtggag gtgcgcggag tcaggcagac agacagacac

361 agccagccag ccaggtcggc agtatagtcc gaactgcaaa tcttattttc ttttcacctt

421 ctctctaact gcccagagct agcgcctgtg gctcccgggc tggtggttcg ggagtgtcca

481 gagagccttg tctccagccg gccccgggag gagagccctg ctgcccaggc gctgttgaca

541 gcggcggaaa gcagcggtac cccacgcgcc cgccggggga cgtcggcgag cggctgcagc

601 agcaaagaac tttcccggcg gggaggaccg gagacaagtg gcagagtccc ggagcgaact

661 tttgcaagcc tttcctgcgt cttaggcttc tccacggcgg taaagaccag aaggcggcgg

721 agagccacgc aagagaagaa ggacgtgcgc tcagcttcgc tcgcaccggt tgttgaactt

781 gggcgagcgc gagccgcggc tgccgggcgc cccctccccc tagcagcgga ggaggggaca

841 agtcgtcgga gtccgggcgg ccaagacccg ccgccggccg gccactgcag ggtccgcact

901 gatccgctcc gcggggagag ccgctgctct gggaagtgag ttcgcctgcg gactccgagg

961 aaccgctgcg cccgaagagc gctcagtgag tgaccgcgac ttttcaaagc cgggtagcgc

1021 gcgcgagtcg acaagtaaga gtgcgggagg catcttaatt aaccctgcgc tccctggagc

1081 gagctggtga ggagggcgca gcggggacga cagccagcgg gtgcgtgcgc tcttagagaa

1141 actttccctg tcaaaggctc cggggggcgc gggtgtcccc cgcttgccag agccctgttg

1201 cggccccgaa acttgtgcgc gcacgccaaa ctaacctcac gtgaagtgac ggactgttct

1261 atgactgcaa agatggaaac gaccttctat gacgatgccc tcaacgcctc gttcctcccg

1321 tccgagagcg gaccttatgg ctacagtaac cccaagatcc tgaaacagag catgaccctg

1381 aacctggccg acccagtggg gagcctgaag ccgcacctcc gcgccaagaa ctcggacctc

1441 ctcacctcgc ccgacgtggg gctgctcaag ctggcgtcgc ccgagctgga gcgcctgata

1501 atccagtcca gcaacgggca catcaccacc acgccgaccc ccacccagtt cctgtgcccc

1561 aagaacgtga cagatgagca ggaggggttc gccgagggct tcgtgcgcgc cctggccgaa

1621 ctgcacagcc agaacacgct gcccagcgtc acgtcggcgg cgcagccggt caacggggca

1681 ggcatggtgg ctcccgcggt agcctcggtg gcagggggca gcggcagcgg cggcttcagc

1741 gccagcctgc acagcgagcc gccggtctac gcaaacctca gcaacttcaa cccaggcgcg

1801 ctgagcagcg gcggcggggc gccctcctac ggcgcggccg gcctggcctt tcccgcgcaa

1861 ccccagcagc agcagcagcc gccgcaccac ctgccccagc agatgcccgt gcagcacccg

1921 cggctgcagg ccctgaagga ggagcctcag acagtgcccg agatgcccgg cgagacaccg

1981 cccctgtccc ccatcgacat ggagtcccag gagcggatca aggcggagag gaagcgcatg

2041 aggaaccgca tcgctgcctc caagtgccga aaaaggaagc tggagagaat cgcccggctg

2101 gaggaaaaag tgaaaacctt gaaagctcag aactcggagc tggcgtccac ggccaacatg

2161 ctcagggaac aggtggcaca gcttaaacag aaagtcatga accacgttaa cagtgggtgc

2221 caactcatgc taacgcagca gttgcaaaca ttttgaagag agaccgtcgg gggctgaggg

2281 gcaacgaaga aaaaaaataa cacagagaga cagacttgag aacttgacaa gttgcgacgg

2341 agagaaaaaa gaagtgtccg agaactaaag ccaagggtat ccaagttgga ctgggttcgg

2401 tctgacggcg cccccagtgt gcacgagtgg gaaggacttg gtcgcgccct cccttggcgt

2461 ggagccaggg agcggccgcc tgcgggctgc cccgctttgc ggacgggctg tccccgcgcg

2521 aacggaacgt tggactttcg ttaacattga ccaagaactg catggaccta acattcgatc

2581 tcattcagta ttaaaggggg gagggggagg gggttacaaa ctgcaataga gactgtagat

2641 tgcttctgta gtactcctta agaacacaaa gcggggggag ggttggggag gggcggcagg

2701 agggaggttt gtgagagcga ggctgagcct acagatgaac tctttctggc ctgctttcgt

2761 taactgtgta tgtacatata tatatttttt aatttgatta aagctgatta ctgtcaataa

2821 acagcttcat gcctttgtaa gttatttctt gtttgtttgt ttgggtatcc tgcccagtgt

2881. tgtttgtaaa taagagattt ggagcactct gagtttacca tttgtaataa agtatataat

2941 ttttttatgt tttgtttctg aaaattccag aaaggatatt taagaaaata caataaacta

3001 ttggaaagta ctcccctaac ctcttttctg catcatctgt agatcctagt ctatctaggt

3061 ggagttgaaa gagttaagaa tgctcgataa aatcactctc agtgcttctt actattaagc

3121 agtaaaaact gttctctatt agacttagaa ataaatgtac ctgatgtacc tgatgctatg

3181 tcaggcttca tactccacgc tcccccagcg tatctatatg gaattgctta ccaaaggcta

3241 gtgcgatgtt tcaggaggct ggaggaaggg gggttgcagt ggagagggac agcccactga

3301 gaagtcaaac atttcaaagt ttggattgca tcaagtggca tgtgctgtga ccatttataa

3361 tgttagaaat tttacaatag gtgcttattc tcaaagcagg aattggtggc agattttaca

3421 aaagatgtat ccttccaatt tggaatcttc tctttgacaa ttcctagata aaaagatggc EPI-109 835

3481 ctttgtctta tgaatattta taacagcatt ctgtcacaat aaatgtattc aaataccaat 3541 aacagatctt gaattgcttc cctttactac ttttttgttc ccaagttata tactgaagtt 3601 tttattttta gttgctgagg tt

(2) INFORMATION FOR SEQ ID NO: 2663: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2663

1 cggccccaga aaacccgagc gagtaggggg cggcgcgcag gagggaggag aactgggggc

61 gcgggaggct ggtgggtgtc gggggtggag atgtagaaga tgtgacgccg cggcccggcg

121 ggtgccagat tagcggacgg ctgcccgcgg ttgcaacggg atcccgggcg ctgcagcttg

181 ggaggcggct ctccccaggc ggcgtccgcg gagacaccca tccgtgaacc ccaggtcccg

241 ggccgccggc tcgccgcgca ccaggggccg gcggacagaa gagcggccga gcggctcgag

301 gctgggggac cgcgggcgcg gccgcgcgct gccgggcggg aggctggggg gccggggccg

361 gggccgtgcc ccggagcggg tcggaggccg gggccggggc cgggggacgg cggctccccg

421 cgcggctcca gcggctcggg gatcccggcc gggccccgca gggaccatgg cagccgggag

481 catcaccacg ctgcccgcct tgcccgagga tggcggcagc ggcgccttcc cgcccggcca

541 cttcaaggac cccaagcggc tgtactgcaa aaacgggggc ttcttcctgc gcatccaccc

601 cgacggccga gttgacgggg tccgggagaa gagcgaccct cacatcaagc tacaacttca

661 agcagaagag agaggagttg tgtctatcaa aggagtgtgt gctaaccgtt acctggctat

721 gaaggaagat ggaagattac tggcttctaa atgtgttacg gatgagtgtt tcttttttga

781 acgattggaa tctaataact acaatactta ccggtcaagg aaatacacca gttggtatgt

841 ggcactgaaa cgaactgggc agtataaact tggatccaaa acaggacctg ggcagaaagc

901 tatacttttt cttccaatgt ctgctaagag ctgattttaa tggccacatc taatctcatt

961 tcacatgaaa gaagaagtat attttagaaa tttgttaatg agagtaaaag aaaataaatg

1021 tgtatagctc agtttggata attggtcaaa caatttttta tccagtagta aaatatgtaa

1081 ccattgtccc agtaaagaaa aataacaaaa gttgtaaaat gtatattctc ccttttatat

1141 tgcatctgct gttacccagt gaagcttacc tagagcaatg atctttttca cgcatttgct

1201 ttattcgaaa agaggctttt aaaatgtgca tgtttagaaa caaaatttct tcatggaaat

1261 catatacatt agaaaatcac agtcagatgt ttaatcaatc caaaatgtcc actatttctt

1321 atgtcattcg ttagtctaca tgtttctaaa catataaatg tgaatttaat caattccttt

1381 catagtttta taattctctg gcagttcctt atgatagagt ttataaaaca gtcctgtgta

1441 aactgctgga agttcttcca cagtcaggtc aattttgtca aacccttctc tgtacccata

1501 cagcagcagc ctagcaactc tgctggtgat gggagttgta ttttcagtct tcgccaggtc

1561 attgagatcc atccactcac atcttaagca ttcttcctgg caaaaattta tggtgaatga

1621 atatggcttt aggcggcaga tgatatacat atctgacttc ccaaaagctc caggatttgt

1681 gtgctgttgc cgaatactca ggacggacct gaattctgat tttataccag tctcttcaaa

1741 aacttctcga accgctgtgt ctcctacgta aaaaaagaga tgtacaaatc aataataatt

1801 acacttttag aaactgtatc atcaaagatt ttcagttaaa gtagcattat gtaaaggctc

1861 aaaacattac cctaacaaag taaagttttc aatacaaatt ctttgccttg tggatatcaa

1921 gaaatcccaa aatattttct taccactgta aattcaagaa gcttttgaaa tgctgaatat

1981 ttctttggct gctacttgga ggcttatcta cctgtacatt tttggggtca gctcttttta

2041 acttcttgct gctctttttc ccaaaaggta aaaatataga ttgaaaagtt aaaacatttt

2101 gcatggctgc agttcctttg tttcttgaga taagattcca aagaacttag attcatttct

2161 tcaacaccga aatgctggag gtgtttgatc agttttcaag aaacttggaa tataaataat

2221 tttataattc aacaaaggtt ttcacatttt ataaggttga tttttcaatt aaatgcaaat

2281 ttgtgtggca ggatttttat tgccattaac atatttttgt ggctgctttt tctacacatc

2341 cagatggtcc ctctaactgg gctttctcta attttgtgat gttctgtcat tgtctcccaa

2401 agtatttagg agaagccctt taaaaagctg ccttcctcta ccactttgct ggaaagcttc

2461 acaattgtca cagacaaaga tttttgttcc aatactcgtt ttgcctctat ttttcttgtt

2521 tgtcaaatag taaatgatat ttgcccttgc agtaattcta ctggtgaaaa acatgcaaag

2581 aagaggaagt cacagaaaca tgtctcaatt cccatgtgct gtgactgtag actgtcttac

2641 catagactgt cttacccatc ccctggatat gctcttgttt tttccctcta atagctatgg

2701 aaagatgcat agaaagagta taatgtttta aaacataagg cattcatctg ccatttttca

2761 attacatgct gacttccctt acaattgaga tttgcccata ggttaaacat ggttagaaac

2821 aactgaaagc ataaaagaaa aatctaggcc gggtgcagtg gctcatgcct atattccctg

2881 cactttggga ggccaaagca ggaggatcgc ttgagcccag gagttcaaga ccaacctggt

2941 gaaaccccgt ctctacaaaa aaacacaaaa aatagccagg catggtggcg tgtacatgtg

3001 gtctcagata cttgggaggc tgaggtggga gggttgatca cttgaggctg agaggtcaag

3061 gttgcagtga gccataatcg tgccactgca gtccagccta ggcaacagag tgagactttg

3121 tctcaaaaaa agagaaattt tccttaataa gaaaagtaat ttttactctg atgtgcaata

3181 catttgttat taaatttatt atttaagatg gtagcactag tcttaaattg tataaaatat

3241 cccctaacat gtttaaatgt ccatttttat tcattatgct ttgaaaaata attatgggga

3301 aatacatgtt tgttattaaa tttattatta aagatagtag cactagtctt aaatttgata

3361 taacatctcc taacttgttt aaatgtccat ttttattctt tatgcttgaa aataaattat

3421 ggggatccta tttagctctt agtaccacta atcaaaagtt cggcatgtag ctcatgatct EPI-109 836

3481 atgctgtttc tatgtcgtgg aagcaccgga tgggggtagt gagcaaatct gccctgctca 3541 gcagtcacca tagcagctga ctgaaaatca gcactgcctg agtagttttg atcagtttaa 3601 cttgaatcac taactgactg aaaattgaat gggcaaataa gtgcttttgt ctccagagta 3661 tgcgggagac ccttccacct caagatggat atttcttccc caaggatttc aagatgaatt 3721 gaaattttta atcaagatag tgtgctttat tctgttgtat tttttattat tttaatatac 3781 tgtaagccaa actgaaataa catttgctgt tttataggtt tgaagaacat aggaaaaact 3841 aagaggtttt gtttttattt ttgctgatga agagatatgt ttaaatatgt tgtattgttt 3901 tgtttagtta caggacaata atgaaatgga gtttatattt gttatttcta ttttgttata 3961 tttaataata gaattagatt gaaataaaat ataatgggaa ataatctgca gaatgtgggt 4021 ttcctggtgt ttcctctgac tctagtgcac tgatgatctc tgataaggct cagctgcttt 4081 atagttctct ggctaatgca gcagatactc ttcctgccag tggtaatacg attttttaag 4141 aaggcagttt gtcaatttta atcttgtgga tacctttata ctcttagggt attattttat 4201 acaaaagcct tgaggattg.c attctatttt ctatatgacc ctcttgatat ttaaaaaaca 4261 ctatggataa caattcttca tttacctagt attatgaaag aatgaaggag ttcaaacaaa 4321 tgtgtttccc agttaactag ggtttactgt ttgagccaat ataaatgttt aactgtttgt 4381 gatggcagta ttcctaaagt acattgcatg ttttcctaaa tacagagttt aaataatttc 4441 agtaattctt agatgattca gcttcatcat taagaatatc ttttgtttta tgttgagtta 4501 gaaatgcctt catatagaca tagtctttca gacctctact gtcagttttc atttctagct 4561 gctttcaggg ttttatgaat tttcaggcaa agctttaatt tatactaagc ttaggaagta 4621 tggctaatgc caacggcagt ttttttcttc ttaattccac atgactgagg catatatgat 4681 ctctgggtag gtgagttgtt gtgacaacca caagcacttt tttttttttt aaagaaaaaa 4741 aggtagtgaa tttttaatca tctggacttt aagaaggatt ctggagtata cttaggcctg 4801 aaattatata tatttggctt ggaaatgtgt ttttcttcaa ttacatctac aagtaagtac 4861 agctgaaatt cagaggaccc ataagagttc acatgaaaaa aatcaattca tttgaaaagg 4921 caagatgcag gagagaggaa gccttgcaaa cctgcagact gctttttgcc caatatagat 4981 tgggtaaggc tgcaaaacat aagcttaatt agctcacatg ctctgctctc acgtggcacc 5041 agtggatagt gtgagagaat taggctgtag aacaaatggc cttctctttc agcattcaca 5101 ccactacaaa atcatctttt atatcaacag aagaataagc ataaactaag caaaaggtca 5161 ataagtacct gaaaccaaga ttggctagag atatatctta atgcaatcca ttttctgatg 5221 gattgttacg agttggctat ataatgtatg tatggtattt tgatttgtgt aaaagtttta 5281 aaaatcaagc tttaagtaca tggacatttt taaataaaat atttaaagac aatttagaaa 5341 attgccttaa tatcattgtt ggctaaatag aataggggac atgcatatta aggaaaaggt 5401 catggagaaa taatattggt atcaaacaaa tacattgatt tgtcatgata cacattgaat 5461 ttgatccaat agtttaagga ataggtagga aaatttggtt tctatttttc gatttcctgt 5521 aaatcagtga cataaataat tcttagctta ttttatattt ccttgtctta aatactgagc 5581 tcagtaagtt gtgttagggg attatttctc agttgagact ttcttatatg acattttact 5641 atgttttgac ttcctgacta ttaaaaataa atagtagaaa caattttcat aaagtgaaga 5701 attatataat cactgcttta taactgactt tattatattt atttcaaagt tcatttaaag 5761 gctactattc atcctctgtg atggaatggt caggaatttg ttttctcata gtttaattcc 5821 aacaacaata ttagtcgtat ccaaaataac ctttaatgct aaactttact gatgtatatc 5881 caaagcttct ccttttcaga cagattaatc cagaagcagt cataaacaga agaataggtg 5941 gtatgttcct aatgatatta tttctactaa tggaataaac tgtaatatta gaaattatgc 6001 tgctaattat atcagctctg aggtaatttc tgaaatgttc agactcagtc ggaacaaatt 6061 ggaaaattta aatttttatt cttagctata aagcaagaaa gtaaacacat taatttcctc 6121 aacattttta agccaattaa aaatataaaa gatacacacc aatatcttct tcaggctctg 6181 acaggcctcc tggaaacttc cacatatttt tcaactgcag tataaagtca gaaaataaag 6241 ttaacataac tttcactaac acacacatat gtagatttca caaaatccac ctataattgg 6301 tcaaagtggt tgagaatata ttttttagta attgcatgca aaatttttct agcttccatc 6361 ctttctccct cgtttcttct ttttttgggg gagctggtaa ctgatgaaat cttttcccac 6421 cttttctctt caggaaatat aagtggtttt gtttggttaa cgtgatacat tctgtatgaa 6481 tgaaacattg gagggaaaca tctactgaat ttctgtaatt taaaatattt tgctgctagt 6541 taactatgaa cagatagaag aatcttacag atgctgctat aaataagtag aaaatataaa 6601 tttcatcact aaaatatgct attttaaaat ctatttccta tattgtattt ctaatcagat 6661 gtattactct tattatttct attgtatgtg ttaatgattt tatgtaaaaa tgtaattgct 6721 tttcatgagt agtatgaata aaattgatta gtttgtg

(2) INFORMATION FOR SEQ ID NO: 2664:

(i) SEQUENCE CHARACTERISTICS:

.(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2664

1 cagtgagctg tgattgcacc actgcaattt agcctgagtg acagaatgaa aaaaaaattt 61 ttttaaagga aaacacaaaa agaatatgct gtcaacaggg atgggaggaa gaccaccttt 121 actgctatac acatttgtac cttttagatg ttgatcaata tgaatatatt atacacacag 181 acacacacac agacacacac acacacacaa acaatacaat ttaatatcct aagaggatat 241 tgacattaga caggtacaaa agctctagaa atgaggactt tcctcagtga tgactttttt 301 caccaccaaa gtcactcagg catcctgaca agggtaagtg aggggagcct ccttggaaaa EPI-109 837

361 taaactcact tggata tga actcctgcac atacctcaaa gcccatctga aatgtcccct 421 cctacaggaa gttttccctg accctccaag aagcagagtt ctatttcact ggggaaaaca 481 tttcttcttc ttcttttttt tccctgccct gcacatgagc tagaaaacat ttcatgaaac 541 tgggagtttc tgtgctgggc tctgtccctc ccccattcta cttcccctcc ctcagcatgg 601 aagcctctgg aagtggggct ctgactccca gcctacagag agattcctag gaagtgttcg 661 actgataaac gcatggccaa aagtgaactg gggatgaggt ccaagacatc tgcggtgggg 721 ggttctccag accttagtgt tcttccacta caaagtgggt ccaacagaga aaggtctgtg 781 ttcaccaggt ggccctgacc ctgggagagt ccagggcagg gtgcagctgc attcatgctg 841 ctggggaaca tgccctcagg ttactcaccc catggacatg ttggccccag ggactgaaaa 901 gcttaggaaa tggtattgag aaatctgggg cagccccaaa aggggagagg ccatggggag 961 aagggggggc tgagtggggg aaaggcagga gccagataaa aagccagctc cagcaggcgc 1021 tgctcactcc tccccatcct ctccctctgt ccctctgtcc ctctgaccct gcactgtccc 1081 agcaccatg

(2) INFORMATION FOR SEQ ID NO:2665: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2665

1 tttctcccat tctacttccc tcctcagcat tggaagctcg taagtgggct ctgactccca 61 gcctacagag agattcctta agaagtggtt cgactgataa acgcattgcc aaaagtgaac 121 tgggatgagg tccaagacat ctgcggtggg ggttctccag accttagtgt tcttccacta 181 caaagtgggt ccaacagaga aaggtctgtg ttcaccaggt ggccctgacc ctggagagtc 241 cagggcaggg tgcagctgca ttcatgctgc tggggaacat gccctcaggt tactcacccc 301 atgacatgtt ggccccaggg actgaaaagc ttaggaaatg gtattgagaa atctggggca

361 gccaaaaggg gagaggccat ggggagaagg gggggctgag tgggggaaag caggagcgag 421 ataaaaagcc agctccagca ggcgctgctc actcctcccc atcctctccc tctgtccctc 481 tgtccctctg accctgcact gtcccagcac catgggaccc acctcaggtc ccagcctgct 541 gctcctgcta ctaacccacc tccccctggc tctggggagt cccatgtact ctatcatcac 601 ccccaacatc ttgcggctgg agagcgagga gaccatggtg ctggaggccc acgacgcgca 661 aggggatgtt ccagtcactg ttactgtcca cgacttccca ggcaaaaaac tagtgctgtc 721 cagtgagaag actgtgctga cccctgccac caaccacatg ggcaacgtca ccttcacgat

781 cccagccaac agggagttca agtcagaaaa ggggcgcaac aagttcgtga ccgtgcaggc 841 caccttcggg acccaagtgg tggagaaggt ggtgctggtc agcctgcaga gcgggtacct 901 cttcatccag acagacaaga ccatctacac ccctggctcc acagttctct atcggatctt 961 caccgtcaac cacaagctgc tacccgtggg ccggacggtc atggtcaaca ttgagaaccc 1021 ggaaggcatc ccggtcaagc aggactcctt gtcttctcag aaccagcttg gcgtcttgcc 1081 cttgtcttgg gacattccgg aactcgtcaa catgggccag tggaagatcc gagcctacta 1141 tgaaaactca ccacagcagg tcttctccac tgagtttgag gtgaaggagt acgtgctgcc 1201 cagtttcgag gtcatagtgg agcctacaga gaaattctac tacatctata acgagaaggg 1261 cctggaggtc accatcaccg ccaggttcct ctacgggaag aaagtggagg gaactgcctt 1321 tgtcatcttc gggatccagg atggcgaaca gaggatttcc ctgcctgaat ccctcaagcg 1381 cattccgatt gaggatggct cgggggaggt tgtgctgagc cggaaggtac tgctggacgg 1441 ggtgcagaac ctccgagcag aagacctggt ggggaagtct ttgtacgtgt ctgccaccgt 1501 catcttgcac tcaggcagtg acatggtgca ggcagagcgc agcgggatcc ccatcgtgac 1561 ctctccctac cagatccact tcaccaagac acccaagtac ttcaaaccag gaatgccctt 1621 tgacctcatg gtgttcgtga cgaaccctga tggctctcca gcctaccgag tccccgtggc 1681 agtccagggc gaggacactg tgcagtctct aacccaggga gatggcgtgg ccaaactcag 1741 catcaacaca caccccagcc agaagccctt gagcatcacg gtgcgcacga agaagcagga 1801 gctctcggag gcagagcagg ctaccaggac catgcaggct ctgccctaca gcaccgtggg 1861 caactccaac aattacctgc atctctcagt gctacgtaca gagctcagac ccggggagac i 1 cctcaacgtc aacttcctcc tgcgaatgga ccgcgcccac gaggccaaga tccgctacta l θl cacctacctg atcatgaaca agggcaggct gttgaaggcg ggacgccagg tgcgagagcc 2041 cggccaggac ctggtggtgc tgcccctgtc catcaccacc gacttcatcc cttccttccg 2101 cctggtggcg tactacacgc tgatcggtgc cagcggccag agggaggtgg tggccgactc 2161 cgtgtgggtg gacgtcaagg actcctgcgt gggctcgctg gtggtaaaaa gcggccagtc 2221 agaagaccgg cagcctgtac ctgggcagca gatgaccctg aagatagagg gtgaccacgg 2281 ggcccgggtg gtactggtgg ccgtggacaa gggcgtgttc gtgctgaata agaagaacaa 2341 actgacgcag agtaagatct gggacgtggt ggagaaggca gacatcggct gcaccccggg 2401 cagtgggaag gattacgccg gtgtcttctc cgacgcaggg ctgaccttca cgagcagcag 2461 tggccagcag accgcccaga gggcagaact tcagtgcccg cagccagccg cccgccgacg 2521 ccgttccgtg cagctcacgg agaagcgaat ggacaaagtc ggcaagtacc ccaaggagct 2581 gcgcaagtgc tgcgaggacg gcatgcggga gaaccccatg aggttctcgt gccagcgccg 2641 gacccgtttc atctccctgg gcgaggcgtg caagaaggtc ttcctggact gctgcaacta 2701 catcacagag ctgcggcggc agcacgcgcg ggccagccac ctgggcctgg ccaggagtaa 2761 cctggatgag gacatcattg cagaagagaa catcgtttcc cgaagtgagt tcccagagag 2821 ctggctgtgg aacgttgagg acttgaaaga gccaccgaaa aatggaatct ctacgaagct EPI-109 838

2881 catgaatata tttttgaaag actccatcac cacgtgggag attctggctg tcagcatgtc 2941 ggacaagaaa gggatctgtg tggcagaccc cttcgaggtc acagtaatgc aggacttctt 3001 catcgacctg cggctaccct actctgttgt tcgaaacgag caggtggaaa tccgagccgt 3061 tctctacaat taccggcaga accaagagct caaggtgagg gtggaactac tccacaatcc 3121 agccttctgc agcctggcca ccaccaagag gcgtcaccag cagaccgtaa ccatcccccc 3181 caagtcctcg ttgtccgttc catatgtcat cgtgccgcta aagaccggcc tgcaggaagt 3241 ggaagtcaag gctgccgtct accatcattt catcagtgac ggtgtcagga agtccctgaa 3301 ggtcgtgccg gaaggaatca gaatgaacaa aactgtggct gttcgcaccc tggatccaga 3361 acgcctgggc cgtgaaggag tgcagaaaga ggacatccca cctgcagacc tcagtgacca 3421 agtcccggac accgagtctg agaccagaat tctcctgcaa gggaccccag tggcccagat 3481 gacagaggat gccgtcgacg cggaacggct gaagcacctc attgtgaccc cctcgggctg 3541 cggggaacag aacatgatcg gcatgacgcc cacggtcatc gctgtgcatt acctggatga

3601 aacggagcag tgggagaagt tcggcctaga gaagcggcag ggggccttgg agctcatcaa 3661 gaaggggtac acccagcagc tggccttcag acaacccagc tctgcctttg cggccttcgt 3721 gaaacgggca cccagcacct ggctgaccgc ctacgtggtc aaggtcttct ctctggctgt 3781 caacctcatc gccatcgact cccaagtcct ctgcggggct gttaaatggc tgatcctgga 3841 gaagcagaag cccgacgggg tcttccagga ggatgcgccc gtgatacacc aagaaatgat 3901 tggtggatta cggaacaaca acgagaaaga catggccctc acggcctttg ttctcatctc 3961 gctgcaggag gctaaagata tttgcgagga gcaggtcaac agcctgccag gcagcatcac 4021 taaagcagga gacttccttg aagccaacta catgaaccta cagagatcct acactgtggc 4081 cattgctggc tatgctctgg cccagatggg caggctgaag gggcctcttc ttaacaaatt 4141 tctgaccaca gccaaagata agaaccgctg ggaggaccct ggtaagcagc tctacaacgt 4201 ggaggccaca tcctatgccc tcttggccct actgcagcta aaagactttg actttgtgcc 4261 tcccgtcgtg cgttggctca atgaacagag atactacggt ggtggctatg gctctaccca 4321 ggccaccttc atggtgttcc aagccttggc tcaataccaa aaggacgccc ctgaccacca 4381 ggaactgaac cttgatgtgt ccctccaact gcccagccgc agctccaaga tcacccaccg 4441 tatccactgg gaatctgcca gcctcctgcg atcagaagag accaaggaaa atgagggttt

4501 cacagtcaca gctgaaggaa aaggccaagg caccttgtcg gtggtgacaa tgtaccatgc 4561 taaggccaaa gatcaactca cctgtaataa attcgacctc aaggtcacca taaaaccagc 4621 accggaaaca gaaaagaggc ctcaggatgc caagaacact atgatccttg agatctgtac 4681 caggtaccgg ggagaccagg atgccactat gtctatattg gacatatcca tgatgactgg 4741 ctttgctcca gacacagatg acctgaagca gctggccaat ggtgttgaca gatacatctc 4801 caagtatgag ctggacaaag ccttctccga taggaacacc ctcatcatct acctggacaa 4861 ggtctcacac tctgaggatg actgtctagc tttcaaagtt caccaatact ttaatgtaga 4921 gcttatccag cctggagcag tcaaggtcta cgcctattac aacctggagg aaagctgtac 4981 ccggttctac catccggaaa aggaggatgg aaagctgaac aagctctgcc gtgatgaact 5041 gtgccgctgt gctgaggaga attgcttcat acaaaagtcg gatgacaagg tcaccctgga 5101 agaacggctg gacaaggcct gtgagccagg agtggactat gtgtacaaga cccgactggt 5161 caaggttcag ctgtccaatg actttgacga gtacatcatg gccattgagc agaccatcaa 5221 gtcaggctcg gatgaggtgc aggttggaca gcagcgcacg ttcatcagcc ccatcaagtg 5281 cagagaagcc ctgaagctgg aggagaagaa acactacctc atgtggggtc tctcctccga 5341 tttctgggga gagaagccca acctcagcta catcatcggg aaggacactt gggtggagca 5401 ctggcctgag gaggacgaat gccaagacga agagaaccag aaacaatgcc aggacctcgg 5461 cgccttcacc gagagcatgg ttgtctttgg gtgccccaac tgaccacacc cccattccat 5521 gaacctacag agatcctaca ctgtggccat tgctggctat gctctggccc agatgggcag 5581 gctgaagggg cctcttctta acaaatttct gaccacagcc aaagataaga accgctggga 5641 ggaccctggt aagcagctct acaacgtgga ggccacatcc tatgccctct tggccctact 5701 gcagctaaaa gactttgact ttgtgcctcc cgtcgtgcgt tggctcaatg aacagagata 5761 ctacggtggt ggctatggct ctacccaggc caccttcatg gtgttccaag ccttggctca 5821 ataccaaaag gacgcccctg accaccagga actgaacctt gatgtgtccc tccaactgcc 5881 cagccgcagc tccaagatca cccaccgtat ccactgggaa tctgccagcc tcctgcgatc 5941 agaagag

(2) INFORMATION FOR SEQ ID- NO:2666: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO.-2666

1 ctcctcccca tcctctccct ctgtccctct gtccctctga ccctgcactg tcccagcacc

61 atgggaccca cctcaggtcc cagcctgctg ctcctgctac taacccacct ccccctggct

121 ctggggagtc ccatgtactc tatcatcacc cccaacatct tgcggctgga gagcgaggag

181 accatggtgc tggaggccca cgacgcgcaa ggggatgttc cagtcactgt tactgtccac

241 gacttcccag gcaaaaaact agtgctgtcc agtgagaaga ctgtgctgac ccctgccacc

301 aaccacatgg gcaacgtcac cttcacgatc ccagccaaca gggagttcaa gtcagaaaag

361 gggcgcaaca agttcgtgac cgtgcaggcc accttcggga cccaagtggt ggagaaggtg

421 gtgctggtca gcctgcagag cgggtacctc ttcatccaga cagacaagac catctacacc

481 cctggctcca cagttctcta tcggatcttc accgtcaacc acaagctgct acccgtgggc EPI-109 839

541 cggacggtca tggtcaacat tgagaacccg gaaggcatcc cggtcaagca ggactccttg 601 tcttctcaga accagcttgg cgtcttgccc ttgtcttggg acattccgga actcgtcaac 661 atgggccagt ggaagatccg agcctactat gaaaactcac cacagcaggt cttctccact 721 gagtttgagg tgaaggagta cgtgctgccc agtttcgagg tcatagtgga gcctacagag 781 aaattctact acatctataa cgagaagggc ctggaggtca ccatcaccgc caggttcctc 841 tacgggaaga aagtggaggg aactgccttt gtcatcttcg ggatccagga tggcgaacag 901 aggatttccc tgcctgaatc cctcaagcgc attccgattg aggatggctc gggggaggtt 961 gtgctgagcc ggaaggtact gctggacggg gtgcagaacc tccgagcaga agacctggtg 1021 gggaagtctt tgtacgtgtc tgccaccgtc atcttgcact caggcagtga catggtgcag 1081 gcagagcgca gcgggatccc catcgtgacc tctccctacc agatccactt caccaagaca 1141 cccaagtact tcaaaccagg aatgcccttt gacctcatgg tgttcgtgac gaaccctgat 1201 ggctctccag cctaccgagt ccccgtggca gtccagggcg aggacactgt gcagtctcta 1261 acccagggag atggcgtggc caaactcagc atcaacacac accccagcca gaagcccttg 1321 agcatcacgg tgcgcacgaa gaagcaggag ctctcggagg cagagcaggc taccaggacc 1381 atgcaggctc tgccctacag caccgtgggc aactccaaca attacctgca tctctcagtg 1441 ctacgtacag agctcagacc cggggagacc ctcaacgtca acttcctcct gcgaatggac 1501 cgcgcccacg aggccaagat ccgctactac acctacctga tcatgaacaa gggcaggctg 1561 ttgaaggcgg gacgccaggt gcgagagccc ggccaggacc tggtggtgct gcccctgtcc 1621 atcaccaccg acttcatccc ttccttccgc ctggtggcgt actacacgct gatcggtgcc 1681 agcggccaga gggaggtggt ggccgactcc gtgtgggtgg acgtcaagga ctcctgcgtg 1741 ggctcgctgg tggtaaaaag cggccagtca gaagaccggc agcctgtacc tgggcagcag 1801 atgaccctga agatagaggg tgaccacggg gcccgggtgg tactggtggc cgtggacaag 1861 ggcgtgttcg tgctgaataa gaagaacaaa ctgacgcaga gtaagatctg ggacgtggtg 1921 gagaaggcag acatcggctg caccccgggc agtgggaagg attacgccgg tgtcttctcc 1981 gacgcagggc tgaccttcac gagcagcagt ggccagcaga ccgcccagag ggcagaactt 2041 cagtgcccgc agccagccgc ccgccgacgc cgttccgtgc agctcacgga gaagcgaatg 2101 gacaaagtcg gcaagtaccc caaggagctg cgcaagtgct gcgaggacgg catgcgggag 2161 aaccccatga ggttctcgtg ccagcgccgg acccgtttca tctccctggg cgaggcgtgc 2221 aagaaggtct tcctggactg ctgcaactac atcacagagc tgcggcggca gcacgcgcgg 2281 gccagccacc tgggcctggc caggagtaac ctggatgagg acatcattgc agaagagaac 2341 atcgtttccc gaagtgagtt cccagagagc tggctgtgga acgttgagga cttgaaagag 2401 ccaccgaaaa atggaatctc tacgaagctc atgaatatat ttttgaaaga ctccatcacc 2461 acgtgggaga ttctggctgt cagcatgtcg gacaagaaag ggatctgtgt ggcagacccc 2521 ttcgaggtca cagtaatgca ggacttcttc atcgacctgc ggctacccta ctctgttgtt 2581 cgaaacgagc aggtggaaat ccgagccgtt ctctacaatt accggcagaa ccaagagctc 2641 aaggtgaggg tggaactact ccacaatcca gccttctgca gcctggccac caccaagagg 2701 cgtcaccagc agaccgtaac catccccccc aagtcctcgt tgtccgttcc atatgtcatc 2761 gtgccgctaa agaccggcct gcaggaagtg gaagtcaagg ctgccgtcta ccatcatttc 2821 atcagtgacg gtgtcaggaa gtccctgaag gtcgtgccgg aaggaatcag aatgaacaaa 2881 actgtggctg ttcgcaccct ggatccagaa cgcctgggcc gtgaaggagt gcagaaagag 2941 gacatcccac ctgcagacct cagtgaccaa gtcccggaca ccgagtctga gaccagaatt 3001 ctcctgcaag ggaccccagt ggcccagatg acagaggatg ccgtcgacgc ggaacggctg 3061 aagcacctca ttgtgacccc ctcgggctgc ggggaacaga acatgatcgg catgacgccc 3121 acggtcatcg ctgtgcatta cctggatgaa acggagcagt gggagaagtt cggcctagag 3181 aagcggcagg gggccttgga gctcatcaag aaggggtaca cccagcagct ggccttcaga 3241 caacccagct ctgcctttgc ggccttcgtg aaacgggcac ccagcacctg gctgaccgcc 3301 tacgtggtca aggtcttctc tctggctgtc aacctcatcg ccatcgactc ccaagtcctc 3361 tgcggggctg ttaaatggct gatcctggag aagcagaagc ccgacggggt cttccaggag 3421 gatgcgcccg tgatacacca agaaatgatt ggtggattac ggaacaacaa cgagaaagac 3481 atggccctca cggcctttgt tctcatctcg ctgcaggagg ctaaagatat ttgcgaggag 3541 caggtcaaca gcctgccagg cagcatcact aaagcaggag acttccttga agccaactac 3601 atgaacctac agagatccta cactgtggcc attgctggct atgctctggc ccagatgggc 3661 aggctgaagg ggcctcttct taacaaattt ctgaccacag ccaaagataa gaaccgctgg 3721 gaggaccctg gtaagcagct ctacaacgtg gaggccacat cctatgccct cttggcccta 3781 ctgcagctaa aagactttga ctttgtgcct cccgtcgtgc gttggctcaa tgaacagaga 3841 tactacggtg gtggctatgg ctctacccag gccaccttca tggtgttcca agccttggct 3901 caataccaaa aggacgcccc tgaccaccag gaactgaacc ttgatgtgtc cctccaactg 3961 cccagccgca gctccaagat cacccaccgt atccactggg aatctgccag cctcctgcga 4021 tcagaagaga ccaaggaaaa tgagggtttc acagtcacag ctgaaggaaa aggccaaggc 4081 accttgtcgg tggtgacaat gtaccatgct aaggccaaag atcaactcac ctgtaataaa 4141 ttcgacctca aggtcaccat aaaaccagca ccggaaacag aaaagaggcc tcaggatgcc 4201 aagaacacta tgatccttga gatctgtacc aggtaccggg gagaccagga tgccactatg 4261 tctatattgg acatatccat gatgactggc tttgctccag acacagatga cctgaagcag 4321 ctggccaatg gtgttgacag atacatctcc aagtatgagc tggacaaagc cttctccgat 4381 aggaacaccc tcatcatcta cctggacaag gtctcacact ctgaggatga ctgtctagct 4441 ttcaaagttc accaatactt taatgtagag cttatccagc ctggagcagt caaggtctac 4501 gcctattaca acctggagga aagctgtacc cggttctacc atccggaaaa ggaggatgga 4561 aagctgaaca agctctgccg tgatgaactg tgccgctgtg ctgaggagaa ttgcttcata EPI-109 840

4621 caaaagtcgg atgacaaggt caccctggaa gaacggctgg acaaggcctg tgagccagga

4681 gtggactatg tgtacaagac ccgactggtc aaggttcagc tgtccaatga ctttgacgag

4741 tacatcatgg ccattgagca gaccatcaag tcaggctcgg atgaggtgca ggttggacag

4801 cagcgcacgt tcatcagccc catcaagtgc agagaagccc tgaagctgga ggagaagaaa

4861 cactacctca tgtggggtct ctcctccgat ttctggggag agaagcccaa cctcagctac

4921 atcatcggga aggacacttg ggtggagcac tggcctgagg aggacgaatg ccaagacgaa

4981 gagaaccaga aacaatgcca ggacctcggc gccttcaccg agagcatggt tgtctttggg

5041 tgccccaact gaccacaccc ccattcc

(2) INFORMATION FOR SEQ ID NO: 2667: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2667

1 cagtgagctg tgattgcacc actgcaattt agcctgagtg acagaatgaa aaaaaaattt

61 ttttaaagga aaacacaaaa agaatatgct gtcaacaggg atgggaggaa gaccaccttt

121 actgctatac acatttgtac cttttagatg ttgatcaata tgaatatatt atacacacag

181 acacacacac agacacacac acacacacaa acaatacaat ttaatatcct aagaggatat

241 tgacattaga caggtacaaa agctctagaa atgaggactt tcctcagtga tgactttttt

301 caccaccaaa gtcactcagg catcctgaca agggtaagtg aggggagcct ccttggaaaa

361 taaactcact tggatagtga actcctgcac atacctcaaa gcccatctga aatgtcccct

421 cctacaggaa gttttccctg accctccaag aagcagagtt ctatttcact ggggaaaaca

481 tttcttcttc ttcttttttt tccctgccct gcacatgagc tagaaaacat ttcatgaaac

541 tgggagtttc tgtgctgggc tctgtccctc ccccattcta cttcccctcc ctcagcatgg

601 aagcctctgg aagtggggct ctgactccca gcctacagag agattcctag gaagtgttcg

661 actgataaac gcatggccaa aagtgaactg gggatgaggt ccaagacatc tgcggtgggg

721 ggttctccag accttagtgt tcttccacta caaagtgggt ccaacagaga aaggtctgtg

781 ttcaccaggt ggccctgacc ctgggagagt ccagggcagg gtgcagctgc attcatgctg

841 ctggggaaca tgccctcagg ttactcaccc catggacatg ttggccccag ggactgaaaa

901 gcttaggaaa tggtattgag aaatctgggg cagccccaaa aggggagagg ccatggggag

961 aagggggggc tgagtggggg aaaggcagga gccagataaa aagccagctc cagcaggcgc

1021 tgctcactcc tccccatcct ctccctctgt ccctctgtcc ctctgaccct gcactgtccc

1081 agcaccatg

1 tttctcccat tctacttccc tcctcagcat tggaagctcg taagtgggct ctgactccca

61 gcctacagag agattcctta agaagtggtt cgactgataa acgcattgcc aaaagtgaac

121 tgggatgagg tccaagacat ctgcggtggg ggttctccag accttagtgt tcttccacta

181 caaagtgggt ccaacagaga aaggtctgtg ttcaccaggt ggccctgacc ctggagagtc

241 cagggcaggg tgcagctgca ttcatgctgc tggggaacat gccctcaggt tactcacccc

301 atgacatgtt ggccccaggg actgaaaagc ttaggaaatg gtattgagaa atctggggca

361 gccaaaaggg gagaggccat ggggagaagg gggggctgag tgggggaaag caggagcgag

421 ataaaaagcc agctccagca ggcgctgctc actcctcccc atcctctccc tctgtccctc

481 tgtccctctg accctgcact gtcccagcac catgggaccc acctcaggtc ccagcctgct

541 gctcctgcta ctaacccacc tccccctggc tctggggagt cccatgtact ctatcatcac

601 ccccaacatc ttgcggctgg agagcgagga gaccatggtg ctggaggccc acgacgcgca

661 aggggatgtt ccagtcactg ttactgtcca cgacttccca ggcaaaaaac tagtgctgtc

721 cagtgagaag actgtgctga cccctgccac caaccacatg ggcaacgtca ccttcacgat

781 cccagccaac agggagttca agtcagaaaa ggggcgcaac aagttcgtga ccgtgcaggc

841 caccttcggg acccaagtgg tggagaaggt ggtgctggtc agcctgcaga gcgggtacct

901 cttcatccag acagacaaga ccatctacac ccctggctcc acagttctct atcggatctt

961 caccgtcaac cacaagctgc tacccgtggg ccggacggtc atggtcaaca ttgagaaccc

1021 ggaaggcatc ccggtcaagc aggactcctt gtcttctcag aaccagcttg gcgtcttgcc

1081 cttgtcttgg gacattccgg aactcgtcaa catgggccag tggaagatcc gagcctacta

1141 tgaaaactca ccacagcagg tcttctccac tgagtttgag gtgaaggagt acgtgctgcc

1201 cagtttcgag gtcatagtgg agcctacaga gaaattctac tacatctata acgagaaggg

1261 cctggaggtc accatcaccg ccaggttcct ctacgggaag aaagtggagg gaactgcctt

1321 tgtcatcttc gggatccagg atggcgaaca gaggatttcc ctgcctgaat ccctcaagcg

1381 cattccgatt gaggatggct cgggggaggt tgtgctgagc cggaaggtac tgctggacgg

1441 ggtgcagaac ctccgagcag aagacctggt ggggaagtct ttgtacgtgt ctgccaccgt

1501 catcttgcac tcaggcagtg acatggtgca ggcagagcgc agcgggatcc ccatcgtgac

1561 ctctccctac cagatccact tcaccaagac acccaagtac ttcaaaccag gaatgccctt

1621 tgacctcatg gtgttcgtga cgaaccctga tggctctcca gcctaccgag tccccgtggc

1681 agtccagggc gaggacactg tgcagtctct aacccaggga gatggcgtgg ccaaactcag

1741 catcaacaca caccccagcc agaagccctt gagcatcacg gtgcgcacga agaagcagga

1801 gctctcggag gcagagcagg ctaccaggac catgcaggct ctgccctaca gcaccgtggg

1861 caactccaac aattacctgc atctctcagt gctacgtaca gagctcagac ccggggagac

1921 cctcaacgtc aacttcctcc tgcgaatgga ccgcgcccac gaggccaaga tccgctacta

1981 cacctacctg atcatgaaca agggcaggct gttgaaggcg ggacgccagg tgcgagagcc EPI-109 841

2041 cggccaggac ctggtggtgc tgcccctgtc catcaccacc gacttcatcc cttccttccg 2101 cctggtggcg tactacacgc tgatcggtgc cagcggccag agggaggtgg tggccgactc 2161 cgtgtgggtg gacgtcaagg actcctgcgt gggctcgctg gtggtaaaaa gcggccagtc 2221 agaagaccgg cagcctgtac ctgggcagca gatgaccctg aagatagagg gtgaccacgg 2281 ggcccgggtg gtactggtgg ccgtggacaa gggcgtgttc gtgctgaata agaagaacaa 2341 actgacgcag agtaagatct gggacgtggt ggagaaggca gacatcggct gcaccccggg 2401 cagtgggaag gattacgccg gtgtcttctc cgacgcaggg ctgaccttca cgagcagcag 2461 tggccagcag accgcccaga gggcagaact tcagtgcccg cagccagccg cccgccgacg 2521 ccgttccgtg cagctcacgg agaagcgaat ggacaaagtc ggcaagtacc ccaaggagct 2581 gcgcaagtgc tgcgaggacg gcatgcggga gaaccccatg aggttctcgt gccagcgccg 2641 gacccgtttc atctccctgg gcgaggcgtg caagaaggtc ttcctggact gctgcaacta 2701 catcacagag ctgcggcggc agcacgcgcg ggccagccac ctgggcctgg ccaggagtaa 2761 cctggatgag gacatcattg cagaagagaa catcgtttcc cgaagtgagt tcccagagag 2821 ctggctgtgg aacgttgagg acttgaaaga gccaccgaaa aatggaatct ctacgaagct 2881 catgaatata tttttgaaag actccatcac cacgtgggag attctggctg tcagcatgtc 2941 ggacaagaaa gggatctgtg tggcagaccc cttcgaggtc acagtaatgc aggacttctt 3001 catcgacctg cggctaccct actctgttgt tcgaaacgag caggtggaaa tccgagccgt 3061 tctctacaat taccggcaga accaagagct caaggtgagg gtggaactac tccacaatcc 3121 agccttctgc agcctggcca ccaccaagag gcgtcaccag cagaccgtaa ccatcccccc 3181 caagtcctcg ttgtccgttc catatgtcat cgtgccgcta aagaccggcc tgcaggaagt 3241 ggaagtcaag gctgccgtct accatcattt catcagtgac ggtgtcagga agtccctgaa 3301 ggtcgtgccg gaaggaatca gaatgaacaa aactgtggct gttcgcaccc tggatccaga 3361 acgcctgggc cgtgaaggag tgcagaaaga ggacatccca cctgcagacc tcagtgacca 3421 agtcccggac accgagtctg agaccagaat tctcctgcaa gggaccccag tggcccagat 3481 gacagaggat gccgtcgacg cggaacggct gaagcacctc attgtgaccc cctcgggctg 3541 cggggaacag aacatgatcg gcatgacgcc cacggtcatc gctgtgcatt acctggatga 3601 aacggagcag tgggagaagt tcggcctaga gaagcggcag ggggccttgg agctcatcaa 3661 gaaggggtac acccagcagc tggccttcag acaacccagc tctgcctttg cggccttcgt 3721 gaaacgggca cccagcacct ggctgaccgc ctacgtggtc aaggtcttct ctctggctgt 3781 caacctcatc gccatcgact cccaagtcct ctgcggggct gttaaatggc tgatcctgga 3841 gaagcagaag cccgacgggg tcttccagga ggatgcgccc gtgatacacc aagaaatgat 3901 tggtggatta cggaacaaca acgagaaaga catggccctc acggcctttg ttctcatctc 3961 gctgcaggag gctaaagata tttgcgagga gcaggtcaac agcctgccag gcagcatcac 4021 taaagcagga gacttccttg aagccaacta catgaaccta cagagatcct acactgtggc 4081 cattgctggc tatgctctgg cccagatggg caggctgaag gggcctcttc ttaacaaatt 4141 tctgaccaca gccaaagata agaaccgctg ggaggaccct ggtaagcagc tctacaacgt 4201 ggaggccaca tcctatgccc tcttggccct actgcagcta aaagactttg actttgtgcc 4261 tcccgtcgtg cgttggctca atgaacagag atactacggt ggtggctatg gctctaccca 4321 ggccaccttc atggtgttcc aagccttggc tcaataccaa aaggacgccc ctgaccacca 4381 ggaactgaac cttgatgtgt ccctccaact gcccagccgc agctccaaga tcacccaccg 4441 tatccactgg gaatctgcca gcctcctgcg atcagaagag accaaggaaa atgagggttt 4501 cacagtcaca gctgaaggaa aaggccaagg caccttgtcg gtggtgacaa tgtaccatgc 4561 taaggccaaa gatcaactca cctgtaataa attcgacctc aaggtcacca taaaaccagc 4621 accggaaaca gaaaagaggc ctcaggatgc caagaacact atgatccttg agatctgtac 4681 caggtaccgg ggagaccagg atgccactat gtctatattg gacatatcca tgatgactgg 4741 ctttgctcca gacacagatg acctgaagca gctggccaat ggtgttgaca gatacatctc 4801 caagtatgag ctggacaaag ccttctccga taggaacacc ctcatcatct acctggacaa 4861 ggtctcacac tctgaggatg actgtctagc tttcaaagtt caccaatact ttaatgtaga 4921 gcttatccag cctggagcag tcaaggtcta cgcctattac aacctggagg aaagctgtac 4981 ccggttctac catccggaaa aggaggatgg aaagctgaac aagctctgcc gtgatgaact 5041 gtgccgctgt gctgaggaga attgcttcat acaaaagtcg gatgacaagg tcaccctgga 5101 agaacggctg gacaaggcct gtgagccagg agtggactat gtgtacaaga cccgactggt 5161 caaggttcag ctgtccaatg actttgacga gtacatcatg gccattgagc agaccatcaa 5221 gtcaggctcg gatgaggtgc aggttggaca gcagcgcacg ttcatcagcc ccatcaagtg 5281 cagagaagcc ctgaagctgg aggagaagaa acactacctc atgtggggtc tctcctccga 5341 tttctgggga gagaagccca acctcagcta catcatcggg aaggacactt gggtggagca 5401 ctggcctgag gaggacgaat gccaagacga agagaaccag aaacaatgcc aggacctcgg 5461 cgccttcacc gagagcatgg ttgtctttgg gtgccccaac tgaccacacc cccattccat 5521 gaacctacag agatcctaca ctgtggccat tgctggctat gctctggccc agatgggcag 5581 gctgaagggg cctcttctta acaaatttct gaccacagcc aaagataaga accgctggga 5641 ggaccctggt aagcagctct acaacgtgga ggccacatcc tatgccctct tggccctact 5701 gcagctaaaa gactttgact ttgtgcctcc cgtcgtgcgt tggctcaatg aacagagata 5761 ctacggtggt ggctatggct ctacccaggc caccttcatg gtgttccaag ccttggctca 5821 ataccaaaag gacgcccctg accaccagga actgaacctt gatgtgtccc tccaactgcc 5881 cagccgcagc tccaagatca cccaccgtat ccactgggaa tctgccagcc tcctgcgatc 5941 agaagag

1 ctcctcccca tcctctccct ctgtccctct gtccctctga ccctgcactg tcccagcacc 61 atgggaccca cctcaggtcc cagcctgctg ctcctgctac taacccacct ccccctggct EPI-109 842

121 ctggggagtc ccatgtactc tatcatcacc cccaacatct tgcggctgga gagcgaggag

181 accatggtgc tggaggccca cgacgcgcaa ggggatgttc cagtcactgt tactgtccac

241 gacttcccag gcaaaaaact agtgctgtcc agtgagaaga ctgtgctgac ccctgccacc

301 aaccacatgg gcaacgtcac cttcacgatc ccagccaaca gggagttcaa gtcagaaaag

361 gggcgcaaca agttcgtgac cgtgcaggcc accttcggga cccaagtggt ggagaaggtg

421 gtgctggtca gcctgcagag cgggtacctc ttcatccaga cagacaagac catctacacc

481 cctggctcca cagttctcta tcggatcttc accgtcaacc acaagctgct acccgtgggc

541 cggacggtca tggtcaacat tgagaacccg gaaggcatcc cggtcaagca ggactccttg

601 tcttctcaga accagcttgg cgtcttgccc ttgtcttggg acattccgga actcgtcaac

661 atgggccagt ggaagatccg agcctactat gaaaactcac cacagcaggt cttctccact

721 gagtttgagg tgaaggagta cgtgctgccc agtttcgagg tcatagtgga gcctacagag

781 aaattctact acatctataa cgagaagggc ctggaggtca ccatcaccgc caggttcctc

841 tacgggaaga aagtggaggg aactgccttt gtcatcttcg ggatccagga tggcgaacag

901 aggatttccc tgcctgaatc cctcaagcgc attccgattg aggatggctc gggggaggtt

961 gtgctgagcc ggaaggtact gctggacggg gtgcagaacc tccgagcaga agacctggtg

1021 gggaagtctt tgtacgtgtc tgccaccgtc atcttgcact caggcagtga catggtgcag

1081 gcagagcgca gcgggatccc catcgtgacc tctccctacc agatccactt caccaagaca

1141 cccaagtact tcaaaccagg aatgcccttt gacctcatgg tgttcgtgac gaaccctgat

1201 ggctctccag cctaccgagt ccccgtggca gtccagggcg aggacactgt gcagtctcta

1261 acccagggag atggcgtggc caaactcagc atcaacacac accccagcca gaagcccttg

1321 agcatcacgg tgcgcacgaa gaagcaggag ctctcggagg cagagcaggc taccaggacc

1381 atgcaggctc tgccctacag caccgtgggc aactccaaca attacctgca tctctcagtg

1441 ctacgtacag agctcagacc cggggagacc ctcaacgtca acttcctcct gcgaatggac

1501 cgcgcccacg aggccaagat ccgctactac acctacctga tcatgaacaa gggcaggctg

1561 ttgaaggcgg gacgccaggt gcgagagccc ggccaggacc tggtggtgct gcccctgtcc

1621 atcaccaccg acttcatccc ttccttccgc ctggtggcgt actacacgct gatcggtgcc

1681 agcggccaga gggaggtggt ggccgactcc gtgtgggtgg acgtcaagga ctcctgcgtg

1741 ggctcgctgg tggtaaaaag cggccagtca gaagaccggc agcctgtacc tgggcagcag

1801 atgaccctga agatagaggg tgaccacggg gcccgggtgg tactggtggc cgtggacaag

1861 ggcgtgttcg tgctgaataa gaagaacaaa ctgacgcaga gtaagatctg ggacgtggtg

1921 gagaaggcag acatcggctg caccccgggc agtgggaagg attacgccgg tgtcttctcc

1981 gacgcagggc tgaccttcac gagcagcagt ggccagcaga ccgcccagag ggcagaactt

2041 cagtgcccgc agccagccgc ccgccgacgc cgttccgtgc agctcacgga gaagcgaatg

2101 gacaaagtcg gcaagtaccc caaggagctg cgcaagtgct gcgaggacgg catgcgggag

2161 aaccccatga ggttctcgtg ccagcgccgg acccgtttca tctccctggg cgaggcgtgc

2221 aagaaggtct tcctggactg ctgcaactac atcacagagc tgcggcggca gcacgcgcgg

2281 gccagccacc tgggcctggc caggagtaac ctggatgagg acatcattgc agaagagaac

2341 atcgtttccc gaagtgagtt cccagagagc tggctgtgga acgttgagga cttgaaagag

2401 ccaccgaaaa atggaatctc tacgaagctc atgaatatat ttttgaaaga ctccatcacc

2461 acgtgggaga ttctggctgt cagcatgtcg gacaagaaag ggatctgtgt ggcagacccc

2521 ttcgaggtca cagtaatgca ggacttcttc atcgacctgc ggctacccta ctctgttgtt

2581 cgaaacgagc aggtggaaat ccgagccgtt ctctacaatt accggcagaa ccaagagctc

2641 aaggtgaggg tggaactact ccacaatcca gccttctgca gcctggccac caccaagagg

2701 cgtcaccagc agaccgtaac catccccccc aagtcctcgt tgtccgttcc atatgtcatc

2761 gtgccgctaa agaccggcct gcaggaagtg gaagtcaagg ctgccgtcta ccatcatttc

2821 atcagtgacg gtgtcaggaa gtccctgaag gtcgtgccgg aaggaatcag aatgaacaaa

2881 actgtggctg ttcgcaccct ggatccagaa cgcctgggcc gtgaaggagt gcagaaagag

2941 gacatcccac ctgcagacct cagtgaccaa gtcccggaca ccgagtctga gaccagaatt

3001 ctcctgcaag ggaccccagt ggcccagatg acagaggatg ccgtcgacgc ggaacggctg

3061 aagcacctca ttgtgacccc ctcgggctgc ggggaacaga acatgatcgg catgacgccc

3121 acggtcatcg ctgtgcatta cctggatgaa acggagcagt gggagaagtt cggcctagag

3181 aagcggcagg gggccttgga gctcatcaag aaggggtaca cccagcagct ggccttcaga

3241 caacccagct ctgcctttgc ggccttcgtg aaacgggcac ccagcacctg gctgaccgcc

3301 tacgtggtca aggtcttctc tctggctgtc aacctcatcg ccatcgactc ccaagtcctc

3361 tgcggggctg ttaaatggct gatcctggag aagcagaagc ccgacggggt cttccaggag

3421 gatgcgcccg tgatacacca agaaatgatt ggtggattac ggaacaacaa cgagaaagac

3481 atggccctca cggcctttgt tctcatctcg ctgcaggagg ctaaagatat ttgcgaggag

3541 caggtcaaca gcctgccagg cagcatcact aaagcaggag acttccttga agccaactac

3601 atgaacctac agagatccta cactgtggcc attgctggct atgctctggc ccagatgggc

3661 aggctgaagg ggcctcttct taacaaattt ctgaccacag ccaaagataa gaaccgctgg

3721 gaggaccctg gtaagcagct ctacaacgtg gaggccacat cctatgccct cttggcccta

3781 ctgcagctaa aagactttga ctttgtgcct cccgtcgtgc gttggctcaa tgaacagaga

3841 tactacggtg gtggctatgg ctctacccag gccaccttca tggtgttcca agccttggct

3901 caataccaaa aggacgcccc tgaccaccag gaactgaacc ttgatgtgtc cctccaactg

3961 cccagccgca gctccaagat cacccaccgt atccactggg aatctgccag cctcctgcga

4021 tcagaagaga ccaaggaaaa tgagggtttc acagtcacag ctgaaggaaa aggccaaggc

4081 accttgtcgg tggtgacaat gtaccatgct aaggccaaag atcaactcac ctgtaataaa

4141 ttcgacctca aggtcaccat aaaaccagca ccggaaacag aaaagaggcc tcaggatgcc EPI-109 843

4201 aagaacacta tgatccttga gatctgtacc aggtaccggg gagaccagga tgccactatg 4261 tctatattgg acatatccat gatgactggc tttgctccag acacagatga cctgaagcag 4321 ctggccaatg gtgttgacag atacatctcc aagtatgagc tggacaaagc cttctccgat 4381 aggaacaccc tcatcatcta cctggacaag gtctcacact ctgaggatga ctgtctagct 4441 ttcaaagttc accaatactt taatgtagag cttatccagc ctggagcagt caaggtctac 4501 gcctattaca acctggagga aagctgtacc cggttctacc atccggaaaa ggaggatgga 4561 aagctgaaca agctctgccg tgatgaactg tgccgctgtg ctgaggagaa ttgcttcata 4621 caaaagtcgg atgacaaggt caccctggaa gaacggctgg acaaggcctg tgagccagga 4681 gtggactatg tgtacaagac ccgactggtc aaggttcagc tgtccaatga ctttgacgag 4741 tacatcatgg ccattgagca gaccatcaag tcaggctcgg atgaggtgca ggttggacag 4801 cagcgcacgt tcatcagccc catcaagtgc agagaagccc tgaagctgga ggagaagaaa 4861 cactacctca tgtggggtct ctcctccgat ttctggggag agaagcccaa cctcagctac 4921 atcatcggga aggacacttg ggtggagcac tggcctgagg aggacgaatg ccaagacgaa 4981 gagaaccaga aacaatgcca ggacctcggc gccttcaccg agagcatggt tgtctttggg 5041 tgccccaact gaccacaccc ccattcc

(2) INFORMATION FOR SEQ ID NO: 2668: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2668

1 cgtgttgatg atggagtagc ttcctttgtg cttaatctcc catctggagt gacggtgctg

61 gagtttaatg tcaaaactga tgctccagat cttccagaag aaaatcaggc cagggaaggt

121 taccgagcaa tagcatactc atctctcagc caaagttacc tttatattga ttggactgat

181 aaccataagg ctttgctagt gggagaacat ctgaatatta ttgttacccc caaaagccca

241 tatattgaca aaataactca ctataattac ttgattttat ccaagggcaa aattatccac

301 tttggcacga gggagaaatt ttcagatgca tcttatcaaa gtataaacat tccagtaaca

361 cagaacatgg ttccttcatc ccgacttctg gtctattata tcgtcacagg agaacagaca

421 gcagaattag tgtctgattc agtctggtta aatattgaag aaaaatgtgg caaccagctc

481 caggttcatc tgtctcctga tgcagatgca tattctccag gccaaactgt gtctcttaat

541 atggcaactg gaatggattc ctgggtggca ttagcagcag tggacagtgc tgtgtatgga

601 gtccaaagag gagccaaaaa gcccttggaa agagtatttc aattcttaga gaagagtgat

661 ctgggctgtg gggcaggtgg tggcctcaac aatgccaatg tgttccacct agctggactt

721 accttcctca ctaatgcaaa tgcagatgac tcccaagaaa atgatgaacc ttgtaaagaa

781 attctcaggc caagaagaac gctgcaaaag aagatagaag aaatagctgc taaatataaa

841 cattcagtag tgaagaaatg ttgttacgat ggagcctgcg ttaataatga tgaaacctgt

901 gagcagcgag ctgcacggat tagtttaggg ccaagatgca tcaaagcttt cactgaatgt

961 tgtgtcgtcg caagccagct ccgtgctaat atctctcata aagacatgca attgggaagg

1021 ctacacatga agaccctgtt accagtaagc aagccagaaa ttcggagtta ttttccagaa

1081 agctggttgt gggaagttca tcttgttccc agaagaaaac agttgcagtt tgccctacct

1141 gattctctaa ccacctggga aattcaaggc attggcattt caaacactgg tatatgtgtt

1201 gctgatactg tcaaggcaaa ggtgttcaaa gatgtcttcc tggaaatgaa tataccatat

1261 tctgttgtac gaggagaaca gatccaattg aaaggaactg tttacaacta taggacttct

1321 gggatgcagt tctgtgttaa aatgtctgct gtggagggaa tctgcacttc ggaaagccca

1381 gtcattgatc atcagggcac aaagtcctcc aaatgtgtgc gccagaaagt agagggctcc

1441 tccagtcact tggtgacatt cactgtgctt cctctggaaa ttggccttca caacatcaat

1501 ttttcactgg agacttggtt tggaaaagaa atcttagtaa aaacattacg agtggtgcca

1561 gaaggtgtca aaagggaaag ctattctggt gttactttgg atcctagggg tatttatggt

1621 accattagca gacgaaagga gttcccatac aggataccct tagatttggt ccccaaaaca

1681 gaaatcaaaa ggattttgag tgtaaaagga ctgcttgtag gtgagatctt gtctgcagtt

1741 ctaagtcagg aaggcatcaa tatcctaacc cacctcccca aagggagtgc agaggcggag

1801 ctgatgagcg ttgtcccagt attctatgtt tttcactacc tggaaacagg aaatcattgg

1861 aacatttttc attctgaccc attaattgaa aagcagaaac tgaagaaaaa attaaaagaa

1921 gggatgttga gcattatgtc ctacagaaat gctgactact cttacagtgt gtggaagggt

1981 ggaagtgcta gcacttggtt aacagctttt gctttaagag tacttggaca agtaaataaa

2041 tacgtagagc agaaccaaaa ttcaatttgt aattctttat tgtggctagt tgagaattat

2101 caattagata atggatcttt caaggaaaat tcacagtatc aaccaataaa attacagggt

2161 accttgcctg ttgaagcccg agagaacagc ttatatctta cagcctttac tgtgattgga

2221 attagaaagg ctttcgatat atgccccctg gtgaaaatcg acacagctct aattaaagct

2281 gacaactttc tgcttgaaaa tacactgcca gcccagagca cctttacatt ggccatttct

2341 gcgtatgctc tttccctggg agataaaact cacccacagt ttcgttcaat tgtttcagct

2401 ttgaagagag aagctttggt taaaggtaat ccacccattt atcgtttttg gaaagacaat

2461 cttcagcata aagacagctc tgtacctaac actggtacgg cacgtatggt agaaacaact

2521 gcctatgctt tactcaccag tctgaacttg aaagatataa attatgttaa cccagtcatc

2581 aaatggctat cagaagagca gaggtatgga ggtggctttt attcaaccca ggacacaatc

2641 aatgccattg agggcctgac ggaatattca ctcctggtta aacaactccg cttgagtatg

2701 gacatcgatg tttcttacaa gcataaaggt gccttacata attataaaat gacagacaag EPI-109 844

2761 aatttccttg ggaggccagt agaggtgctt ctcaatgatg acctcattgt cagtacagga 2821 tttggcagtg gcttggctac agtacatgta acaactgtag ttcacaaaac cagtacctct 2881 gaggaagttt gcagctttta tttgaaaatc gatactcagg atattgaagc atcccactac 2941 agaggctacg gaaactctga ttacaaacgc atagtagcat gtgccagcta caagcccagc 3001 agggaagaat catcatctgg atcctctcat gcggtgatgg acatctcctt gcctactgga 3061 atcagtgcaa atgaagaaga cttaaaagcc cttgtggaag gggtggatca actattcact 3121 gattaccaaa tcaaagatgg acatgttatt ctgcaactga attcgattcc ctccagtgat 3181 ttcctttgtg tacgattccg gatatttgaa ctctttgaag ttgggtttct cagtcctgcc 3241 actttcacag tgtacgaata ccacagacca gataaacagt gtaccatgtt ttatagcact 3301 tccaatatca aaattcagaa agtctgtgaa ggagccgcgt gcaagtgtgt agaagctgat 3361 tgtgggcaaa tgcaggaaga attggatctg acaatctctg cagagacaag aaaacaaaca 3421 gcatgtaaac cagagattgc atatgcttat aaagttagca tcacatccat cactgtagaa 3481 aatgtttttg tcaagtacaa ggcaaccctt ctggatatct acaaaactgg ggaagctgtt 3541 gctgagaaag actctgagat taccttcatt aaaaaggtaa cctgtactaa cgctgagctg 3601 gtaaaaggaa gacagtactt aattatgggt aaagaagccc tccagataaa atacaatttc 3661 agtttcaggt acatctaccc tttagattcc ttgacctgga ttgaatactg gcctagagac 3721 acaacatgtt catcgtgtca agcattttta gctaatttag atgaatttgc cgaagatatc 3781 tttttaaatg gatgctaaaa ttcctgaagt tcagctgcat acagtttgca cttatggact 3841 cctgttgttg aagttcgttt ttttgttttc ttcttttttt aaacattcat agctggtctt 3901 atttgtaaag ctcactttac ttagaattag tggcacttgc ttttattaga gaatgatttc 3961 aaatgctgta actttctgaa ataacatggc cttggagggc atgaagacag atactcctcc 4021 aaggttattg gacaccggaa acaataaatt ggaacacctc ctcaaaccta ccactcagga 4081 atgtttgctg gggccgaaag aacagtccat tgaaagggag tattacaaaa acatggcctt 4141 tgcttgaaag aaaataccaa ggaacaggaa actgatcatt aaagcctgag tttgctttc

(2) INFORMATION FOR SEQ ID NO:2669: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2669

1 ctacctccaa ccatgggcct tttgggaata ctttgttttt taatcttcct ggggaaaacc

61 tggggacagg agcaaacata tgtcatttca gcaccaaaaa tattccgtgt tggagcatct

121 gaaaatattg tgattcaagt ttatggatac actgaagcat ttgatgcaac aatctctatt

181 aaaagttatc ctgataaaaa atttagttac tcctcaggcc atgttcattt atcctcagag

241 aataaattcc aaaactctgc aatcttaaca atacaaccaa aacaattgcc tggaggacaa

301 aacccagttt cttatgtgta tttggaagtt gtatcaaagc atttttcaaa atcaaaaaga

361 atgccaataa cctatgacaa tggatttctc ttcattcata cagacaaacc tgtttatact

421 ccagaccagt cagtaaaagt tagagtttat tcgttgaatg acgacttgaa gccagccaaa

481 agagaaactg tcttaacctt catagatcct gaaggatcag aagttgacat ggtagaagaa

541 attgatcata ttggaattat ctcttttcct gacttcaaga ttccgtctaa tcctagatat

601 ggtatgtgga cgatcaaggc taaatataaa gaggactttt caacaactgg aaccgcatat

661 tttgaagtta aagaatatgt cttgccacat ttttctgtct caatcgagcc agaatataat

721 ttcattggtt acaagaactt taagaatttt gaaattacta taaaagcaag atatttttat

781 aataaagtag tcactgaggc tgacgtttat atcacatttg gaataagaga agacttaaaa

841 gatgatcaaa aagaaatgat gcaaacagca atgcaaaaca caatgttgat aaatggaatt gθl gctcaagtca catttgattc tgaaacagca gtcaaagaac tgtcatacta cagtttagaa

961 gatttaaaca acaagtacct ttatattgct gtaacagtca tagagtctac aggtggattt

1021 tctgaagagg cagaaatacc tggcatcaaa tatgtcctct ctccctacaa actgaatttg

1081 gttgctactc ctcttttcct gaagcctggg attccatatc ccatcaaggt gcaggttaaa

1141 gattcgcttg accagttggt aggaggagtc ccagtaatac tgaatgcaca aacaattgat

1201 gtaaaccaag agacatctga cttggatcca agcaaaagtg taacacgtgt tgatgatgga

1261 gtagcttcct ttgtgcttaa tctcccatct ggagtgacgg tgctggagtt taatgtcaaa

1321 actgatgctc cagatcttcc agaagaaaat caggccaggg aaggttaccg agcaatagca

1381 tactcatctc tcagccaaag ttacctttat attgattgga ctgataacca taaggctttg

1441 ctagtgggag aacatctgaa tattattgtt acccccaaaa gcccatatat tgacaaaata

1501 actcactata attacttgat tttatccaag ggcaaaatta tccattttgg cacgagggag

1561 aaattttcag atgcatctta tcaaagtata aacattccag taacacagaa catggttcct

1621 tcatcccgac ttctggtcta ttatatcgtc acaggagaac agacagcaga attagtgtct

1681 gattcagtct ggttaaatat tgaagaaaaa tgtggcaacc agctccaggt tcatctgtct

1741 cctgatgcag atgcatattc tccaggccaa actgtgtctc ttaatatggc aactggaatg

1801 gattcctggg tggcattagc agcagtggac agtgctgtgt atggagtcca aagaggagcc

1861 aaaaagccct tggaaagagt atttcaattc ttagagaaga gtgatctggg ctgtggggca

1921 ggtggtggcc tcaacaatgc caatgtgttc cacctagctg gacttacctt cctcactaat

1981 gcaaatgcag atgactccca agaaaatgat gaaccttgta aagaaattct caggccaaga

2041 agaacgctgc aaaagaagat agaagaaata gctgctaaat ataaacattc agtagtgaag

2101 aaatgttgtt acgatggagc ctgcgttaat aatgatgaaa cctgtgagca gcgagctgca

2161 cggattagtt tagggccaag atgcatcaaa gctttcactg aatgttgtgt cgtcgcaagc EPI-109 845

2221 cagctccgtg ctaatatctc tcataaagac atgcaattgg gaaggctaca catgaagacc 2281 ctgttaccag taagcaagcc agaaattcgg agttattttc cagaaagctg gttgtgggaa 2341 gttcatcttg ttcccagaag aaaacagttg cagtttgccc tacctgattc tctaaccacc 2401 tgggaaattc aaggcattgg catttcaaac actggtatat gtgttgctga tactgtcaag 2461 gcaaaggtgt tcaaagatgt cttcctggaa atgaatatac catattctgt tgtacgagga 2521 gaacagatcc aattgaaagg aactgtttac aactatagga cttctgggat gcagttctgt 2581 gttaaaatgt ctgctgtgga gggaatctgc acttcggaaa gcccagtcat tgatcatcag 2641 ggcacaaagt cctccaaatg tgtgcgccag aaagtagagg gctcctccag tcacttggtg 2701 acattcactg tgcttcctct ggaaattggc cttcacaaca tcaatttttc actggagact 2761 tggtttggaa aagaaatctt agtaaaaaca ttacgagtgg tgccagaagg tgtcaaaagg 2821 gaaagctatt ctggtgttac tttggatcct aggggtattt atggtaccat tagcagacga 2881 aaggagttcc catacaggat acccttagat ttggtcccca aaacagaaat caaaaggatt 2941 ttgagtgtaa aaggactgct tgtaggtgag atcttgtctg cagttctaag tcaggaaggc 3001 atcaatatcc taacccacct ccccaaaggg agtgcagagg cggagctgat gagcgttgtc 3061 ccagtattct atgtttttca ctacctggaa acaggaaatc attggaacat ttttcattct 3121 gacccattaa ttgaaaagca gaaactgaag aaaaaattaa aagaagggat gttgagcatt 3181 atgtcctaca gaaatgctga ctactcttac agtgtgtgga agggtggaag tgctagcact 3241 tggttaacag cttttgcttt aagagtactt ggacaagtaa ataaatacgt agagcagaac 3301 caaaattcaa tttgtaattc tttattgtgg ctagttgaga attatcaatt agataatgga 3361 tctttcaagg aaaattcaca gtatcaacca ataaaattac agggtacctt gcctgttgaa 3421 gcccgagaga acagcttata tcttacagcc tttactgtga ttggaattag aaaggctttc 3481 gatatatgcc ccctggtgaa aatcgacaca gctctaatta aagctgacaa ctttctgctt 3541 gaaaatacac tgccagccca gagcaccttt acattggcca tttctgcgta tgctctttcc 3601 ctgggagata aaactcaccc acagtttcgt tcaattgttt cagctttgaa gagagaagct 3661 ttggttaaag gtaatccacc catttatcgt ttttggaaag acaatcttca gcataaagac 3721 agctctgtac ctaacactgg tacggcacgt atggtagaaa caactgccta tgctttactc 3781 accagtctga acttgaaaga tataaattat gttaacccag tcatcaaatg gctatcagaa 3841 gagcagaggt atggaggtgg cttttattca acccaggaca ccatcaatgc cattgagggc 3901 ctgacggaat attcactcct ggttaaacaa ctccgcttga gtatggacat cgatgtttct 3961 tacaagcata aaggtgcctt acataattat aaaatgacag acaagaattt ccttgggagg 4021 ccagtagagg tgcttctcaa tgatgacctc attgtcagta caggatttgg cagtggcttg 4081 gctacagtac atgtaacaac tgtagttcac aaaaccagta cctctgagga agtttgcagc 4141 ttttatttga aaatcgatac tcaggatatt gaagcatccc actacagagg ctacggaaac 4201 tctgattaca aacgcatagt agcatgtgcc agctacaagc ccagcaggga agaatcatca 4261 tctggatcct ctcatgcggt gatggacatc tccttgccta ctggaatcag tgcaaatgaa 4321 gaagacttaa aagcccttgt ggaaggggtg gatcaactat tcactgatta ccaaatcaaa 4381 gatggacatg ttattctgca actgaattcg attccctcca gtgatttcct ttgtgtacga 4441 ttccggatat ttgaactctt tgaagttggg tttctcagtc ctgccacttt cacagtttac 4501 gaataccaca gaccagataa acagtgtacc atgttttata gcacttccaa tatcaaaatt 4561 cagaaagtct gtgaaggagc cgcgtgcaag tgtgtagaag ctgattgtgg gcaaatgcag 4621 gaagaattgg atctgacaat ctctgcagag acaagaaaac aaacagcatg taaaccagag 4681 attgcatatg cttataaagt tagcatcaca tccatcactg tagaaaatgt ttttgtcaag 4741 tacaaggcaa cccttctgga tatctacaaa actggggaag ctgttgctga gaaagactct 4801 gagattacct tcattaaaaa ggtaacctgt actaacgctg agctggtaaa aggaagacag 4861 tacttaatta tgggtaaaga agccctccag ataaaataca atttcagttt caggtacatc 4921 taccctttag attccttgac ctggattgaa tactggccta gagacacaac atgttcatcg 4981 tgtcaagcat ttttagctaa tttagatgaa tttgccgaag atatcttttt aaatggatgc 5041 taaaattcct gaagttcagc tgcatacagt ttgcacttat ggactcctgt tgttgaagtt 5101 cgtttttttg ttttcttctt tttttaaaca ttcatagctg gtcttatttg taaagctcac 5161 tttacttaga attagtggca cttgctttta ttagagaatg atttcaaatg ctgtaacttt 5221 ctgaaataac atggccttgg agggcatgaa gacagatact cctccaaggt tattggacac 5281 cggaaacaat aaattggaac acctcctcaa acctaccact caggaatgtt tgctggggcc 5341 gaaagaacag tccattgaaa gggagtatta caaaaacatg gcctttgctt gaaagaaaat 5401 accaaggaac aggaaactga tcattaaagc ctgagtttgc tttc

(2) INFORMATION FOR SEQ ID NO:2670: (i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2670 1 ctacctccaa ccatgggcct tttgggaata ctttgttttt taatcttcct ggggaaaacc 61 tggggacagg agcaaacata tgtcatttca gcaccaaaaa tattccgtgt tggagcatct 121 gaaaatattg tgattcaagt ttatggatac actgaagcat ttgatgcaac aatctctatt 181 aaaagttatc ctgataaaaa atttagttac tcctcaggcc atgttcattt atcctcagag 241 aataaattcc aaaactctgc aatcttaaca atacaaccaa aacaattgcc tggaggacaa 301 aacccagttt cttatgtgta tttggaagtt gtatcaaagc atttttcaaa atcaaaaaga 361 atgccaataa cctatgacaa tggatttctc ttcattcata cagacaaacc tgtttatact EPI-109 846

421 ccagaccagt cagtaaaagt tagagtttat tcgttgaatg acgacttgaa gccagccaaa 481 agagaaactg tcttaacctt catagatcct gaaggatcag aagttgacat ggtagaagaa 541 attgatcata ttggaattat ctcttttcct gacttcaaga ttccgtctaa tcctagatat 601 ggtatgtgga cgatcaaggc taaatataaa gaggactttt caacaactgg aaccgcatat 661 tttgaagtta aagaatatgt cttgccacat ttttctgtct caatcgagcc agaatataat 721 ttcattggtt acaagaactt taagaatttt gaaattacta taaaagcaag atatttttat 781 aataaagtag tcactgaggc tgacgtttat atcacatttg gaataagaga agacttaaaa 841 gatgatcaaa aagaaatgat gcaaacagca atgcaaaaca caatgttgat aaatggaatt θl gctcaagtca catttgattc tgaaacagca gtcaaagaac tgtcatacta cagtttagaa 961 gatttaaaca acaagtacct ttatattgct gtaacagtca tagagtctac aggtggattt 1021 tctgaagagg cagaaatacc tggcatcaaa tatgtcctct ctccctacaa actgaatttg 1081 gttgctactc ctcttttcct gaagcctggg attccatatc ccatcaaggt gcaggttaaa 1141 gattcgcttg accagttggt aggaggagtc ccagtaatac tgaatgcaca aacaattgat 1201 gtaaaccaag agacatctga cttggatcca agcaaaagtg taacacgtgt tgatgatgga 1261 gtagcttcct ttgtgcttaa tctcccatct ggagtgacgg tgctggagtt taatgtcaaa 1321 actgatgctc cagatcttcc agaagaaaat caggccaggg aaggttaccg agcaatagca 1381 tactcatctc tcagccaaag ttacctttat attgattgga ctgataacca taaggctttg 1441 ctagtgggag aacatctgaa tattattgtt acccccaaaa gcccatatat tgacaaaata 1501 actcactata attacttgat tttatccaag ggcaaaatta tccattttgg cacgagggag 1561 aaattttcag atgcatctta tcaaagtata aacattccag taacacagaa catggttcct 1621 tcatcccgac ttctggtcta ttatatcgtc acaggagaac agacagcaga attagtgtct 1681 gattcagtct ggttaaatat tgaagaaaaa tgtggcaacc agctccaggt tcatctgtct 1741 cctgatgcag atgcatattc tccaggccaa actgtgtctc ttaatatggc aactggaatg 1801 gattcctggg tggcattagc agcagtggac agtgctgtgt atggagtcca aagaggagcc 1861 aaaaagccct tggaaagagt atttcaattc ttagagaaga gtgatctggg ctgtggggca 1921 ggtggtggcc tcaacaatgc caatgtgttc cacctagctg gacttacctt cctcactaat 1981 gcaaatgcag atgactccca agaaaatgat gaaccttgta aagaaattct caggccaaga 2041 agaacgctgc aaaagaagat agaagaaata gctgctaaat ataaacattc agtagtgaag 2101 aaatgttgtt acgatggagc ctgcgttaat aatgatgaaa cctgtgagca gcgagctgca 2161 cggattagtt tagggccaag atgcatcaaa gctttcactg aatgttgtgt cgtcgcaagc 2221 cagctccgtg ctaatatctc tcataaagac atgcaattgg gaaggctaca catgaagacc 2281 ctgttaccag taagcaagcc agaaattcgg agttattttc cagaaagctg gttgtgggaa 2341 gttcatcttg ttcccagaag aaaacagttg cagtttgccc tacctgattc tctaaccacc 2401 tgggaaattc aaggcattgg catttcaaac actggtatat gtgttgctga tactgtcaag 2461 gcaaaggtgt tcaaagatgt cttcctggaa atgaatatac catattctgt tgtacgagga 2521 gaacagatcc aattgaaagg aactgtttac aactatagga cttctgggat gcagttctgt 2581 gttaaaatgt ctgctgtgga gggaatctgc acttcggaaa gcccagtcat tgatcatcag 2641 ggcacaaagt cctccaaatg tgtgcgccag aaagtagagg gctcctccag tcacttggtg 2701 acattcactg tgcttcctct ggaaattggc cttcacaaca tcaatttttc actggagact 2761 tggtttggaa aagaaatctt agtaaaaaca ttacgagtgg tgccagaagg tgtcaaaagg 2821 gaaagctatt ctggtgttac tttggatcct aggggtattt atggtaccat tagcagacga 2881 aaggagttcc catacaggat acccttagat ttggtcccca aaacagaaat caaaaggatt 2941 ttgagtgtaa aaggactgct tgtaggtgag atcttgtctg cagttctaag tcaggaaggc 3001 atcaatatcc taacccacct ccccaaaggg agtgcagagg cggagctgat gagcgttgtc 3061 ccagtattct atgtttttca ctacctggaa acaggaaatc attggaacat ttttcattct 3121 gacccattaa ttgaaaagca gaaactgaag aaaaaattaa aagaagggat gttgagcatt 3181 atgtcctaca gaaatgctga ctactcttac agtgtgtgga agggtggaag tgctagcact 3241 tggttaacag cttttgcttt aagagtactt ggacaagtaa ataaatacgt agagcagaac 3301 caaaattcaa tttgtaattc tttattgtgg ctagttgaga attatcaatt agataatgga 3361 tctttcaagg aaaattcaca gtatcaacca ataaaattac agggtacctt gcctgttgaa 3421 gcccgagaga acagcttata tcttacagcc tttactgtga ttggaattag aaaggctttc 3481 gatatatgcc ccctggtgaa aatcgacaca gctctaatta aagctgacaa ctttctgctt 3541 gaaaatacac tgccagccca gagcaccttt acattggcca tttctgcgta tgctctttcc 3601 ctgggagata aaactcaccc acagtttcgt tcaattgttt cagctttgaa gagagaagct 3661 ttggttaaag gtaatccacc catttatcgt ttttggaaag acaatcttca gcataaagac 3721 agctctgtac ctaacactgg tacggcacgt atggtagaaa caactgccta tgctttactc 3781 accagtctga acttgaaaga tataaattat gttaacccag tcatcaaatg gctatcagaa 3841 gagcagaggt atggaggtgg cttttattca acccaggaca ccatcaatgc cattgagggc 3901 ctgacggaat attcactcct ggttaaacaa ctccgcttga gtatggacat cgatgtttct 3961 tacaagcata aaggtgcctt acataattat aaaatgacag acaagaattt ccttgggagg 4021 ccagtagagg tgcttctcaa tgatgacctc attgtcagta caggatttgg cagtggcttg 4081 gctacagtac atgtaacaac tgtagttcac aaaaccagta cctctgagga agtttgcagc 4141 ttttatttga aaatcgatac tcaggatatt gaagcatccc actacagagg ctacggaaac 4201 tctgattaca aacgcatagt agcatgtgcc agctacaagc ccagcaggga agaatcatca 4261 tctggatcct ctcatgcggt gatggacatc tccttgccta ctggaatcag tgcaaatgaa 4321 gaagacttaa aagcccttgt ggaaggggtg gatcaactat tcactgatta ccaaatcaaa 4381 gatggacatg ttattctgca actgaattcg attccctcca gtgatttcct ttgtgtacga 4441 ttccggatat ttgaactctt tgaagttggg tttctcagtc ctgccacttt cacagtttac EPI-109 847

4501 gaataccaca gaccagataa acagtgtacc atgttttata gcacttccaa tatcaaaatt

4561 cagaaagtct gtgaaggagc cgcgtgcaag tgtgtagaag ctgattgtgg gcaaatgcag

4621 gaagaattgg atctgacaat ctctgcagag acaagaaaac aaacagcatg taaaccagag

4681 attgcatatg cttataaagt tagcatcaca tccatcactg tagaaaatgt ttttgtcaag

4741 tacaaggcaa cccttctgga tatctacaaa actggggaag ctgttgctga gaaagactct

4801 gagattacct tcattaaaaa ggtaacctgt actaacgctg agctggtaaa aggaagacag

4861 tacttaatta tgggtaaaga agccctccag ataaaataca atttcagttt caggtacatc

4921 taccctttag attccttgac ctggattgaa tactggccta gagacacaac atgttcatcg

4981 tgtcaagcat ttttagctaa tttagatgaa tttgccgaag atatcttttt aaatggatgc

5041 taaaattcct gaagttcagc tgcatacagt ttgcacttat ggactcctgt tgttgaagtt

5101 cgtttttttg ttttcttctt tttttaaaca ttcatagctg gtcttatttg taaagctcac

5161 tttacttaga attagtggca cttgctttta ttagagaatg atttcaaatg ctgtaacttt

5221 ctgaaataac atggccttgg agggcatgaa gacagatact cctccaaggt tattggacac

5281 cggaaacaat aaattggaac acctcctcaa acctaccact caggaatgtt tgctggggcc

5341 gaaagaacag tccattgaaa gggagtatta caaaaacatg gcctttgctt gaaagaaaat

5401 accaaggaac aggaaactga tcattaaagc ctgagtttgc tttc

(2) INFORMATION FOR SEQ ID NO: 2671:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2671

1 cgtgttgatg atggagtagc ttcctttgtg cttaatctcc catctggagt gacggtgctg

61 gagtttaatg tcaaaactga tgctccagat cttccagaag aaaatcaggc cagggaaggt

121 taccgagcaa tagcatactc atctctcagc caaagttacc tttatattga ttggactgat

181 aaccataagg ctttgctagt gggagaacat ctgaatatta ttgttacccc caaaagccca

241 tatattgaca aaataactca ctataattac ttgattttat ccaagggcaa aattatccac

301 tttggcacga gggagaaatt ttcagatgca tcttatcaaa gtataaacat tccagtaaca

361 cagaacatgg ttccttcatc ccgacttctg gtctattata tcgtcacagg agaacagaca

421 gcagaattag tgtctgattc agtctggtta aatattgaag aaaaatgtgg caaccagctc

481 caggttcatc tgtctcctga tgcagatgca tattctccag gccaaactgt gtctcttaat

541 atggcaactg gaatggattc ctgggtggca ttagcagcag tggacagtgc tgtgtatgga

601 gtccaaagag gagccaaaaa gcccttggaa agagtatttc aattcttaga gaagagtgat

661 ctgggctgtg gggcaggtgg tggcctcaac aatgccaatg tgttccacct agctggactt

721 accttcctca ctaatgcaaa tgcagatgac tcccaagaaa atgatgaacc ttgtaaagaa

781 attctcaggc caagaagaac gctgcaaaag aagatagaag aaatagctgc taaatataaa

841 cattcagtag tgaagaaatg ttgttacgat ggagcctgcg ttaataatga tgaaacctgt

901 gagcagcgag ctgcacggat tagtttaggg ccaagatgca tcaaagcttt cactgaatgt

961 tgtgtcgtcg caagccagct ccgtgctaat atctctcata aagacatgca attgggaagg

1021 ctacacatga agaccctgtt accagtaagc aagccagaaa ttcggagtta ttttccagaa

1081 agctggttgt gggaagttca tcttgttccc agaagaaaac agttgcagtt tgccctacct

1141 gattctctaa ccacctggga aattcaaggc attggcattt caaacactgg tatatgtgtt

1201 gctgatactg tcaaggcaaa ggtgttcaaa gatgtcttcc tggaaatgaa tataccatat

1261 tctgttgtac gaggagaaca gatccaattg aaaggaactg tttacaacta taggacttct

1321 gggatgcagt tctgtgttaa aatgtctgct gtggagggaa tctgcacttc ggaaagccca

1381 gtcattgatc atcagggcac aaagtcctcc aaatgtgtgc gccagaaagt agagggctcc

1441 tccagtcact tggtgacatt cactgtgctt cctctggaaa ttggccttca caacatcaat

1501 ttttcactgg agacttggtt tggaaaagaa atcttagtaa aaacattacg agtggtgcca

1561 gaaggtgtca aaagggaaag ctattctggt gttactttgg atcctagggg tatttatggt

1621 accattagca gacgaaagga gttcccatac aggataccct tagatttggt ccccaaaaca

1681 gaaatcaaaa ggattttgag tgtaaaagga ctgcttgtag gtgagatctt gtctgcagtt

1741 ctaagtcagg aaggcatcaa tatcctaacc cacctcccca aagggagtgc agaggcggag

1801 ctgatgagcg ttgtcccagt attctatgtt tttcactacc tggaaacagg aaatcattgg

1861 aacatttttc attctgaccc attaattgaa aagcagaaac tgaagaaaaa attaaaagaa

1921 gggatgttga gcattatgtc ctacagaaat gctgactact cttacagtgt gtggaagggt

1981 ggaagtgcta gcacttggtt aacagctttt gctttaagag tacttggaca agtaaataaa

2041 tacgtagagc agaaccaaaa ttcaatttgt aattctttat tgtggctagt tgagaattat

2101 caattagata atggatcttt caaggaaaat tcacagtatc aaccaataaa attacagggt

2161 accttgcctg ttgaagcccg agagaacagc ttatatctta cagcctttac tgtgattgga

2221 attagaaagg ctttcgatat atgccccctg gtgaaaatcg acacagctct aattaaagct

2281 gacaactttc tgcttgaaaa tacactgcca gcccagagca cctttacatt ggccatttct

2341 gcgtatgctc tttccctggg agataaaact cacccacagt ttcgttcaat tgtttcagct

2401 ttgaagagag aagctttggt taaaggtaat ccacccattt atcgtttttg gaaagacaat

2461 cttcagcata aagacagctc tgtacctaac actggtacgg cacgtatggt agaaacaact

2521 gcctatgctt tactcaccag tctgaacttg aaagatataa attatgttaa cccagtcatc

2581 aaatggctat cagaagagca gaggtatgga ggtggctttt attcaaccca ggacacaatc

2641 aatgccattg agggcctgac ggaatattca ctcctggtta aacaactccg cttgagtatg EPI-109 848

2701 gacatcgatg tttcttacaa gcataaaggt gccttacata attataaaat gacagacaag

2761 aatttccttg ggaggccagt agaggtgctt ctcaatgatg acctcattgt cagtacagga

2821 tttggcagtg gcttggctac agtacatgta acaactgtag ttcacaaaac cagtacctct

2881 gaggaagttt gcagctttta tttgaaaatc gatactcagg atattgaagc atcccactac

2941 agaggctacg gaaactctga ttacaaacgc atagtagcat gtgccagcta caagcccagc

3001 agggaagaat catcatctgg atcctctcat gcggtgatgg acatctcctt gcctactgga

3061 atcagtgcaa atgaagaaga cttaaaagcc cttgtggaag gggtggatca actattcact

3121 gattaccaaa tcaaagatgg acatgttatt ctgcaactga attcgattcc ctccagtgat

3181 ttcctttgtg tacgattccg gatatttgaa ctctttgaag ttgggtttct cagtcctgcc

3241 actttcacag tgtacgaata ccacagacca gataaacagt gtaccatgtt ttatagcact

3301 tccaatatca aaattcagaa agtctgtgaa ggagccgcgt gcaagtgtgt agaagctgat

3361 tgtgggcaaa tgcaggaaga attggatctg acaatctctg cagagacaag aaaacaaaca

3421 gcatgtaaac cagagattgc atatgcttat aaagttagca tcacatccat cactgtagaa

3481 aatgtttttg tcaagtacaa ggcaaccctt ctggatatct acaaaactgg ggaagctgtt

3541 gctgagaaag actctgagat taccttcatt aaaaaggtaa cctgtactaa cgctgagctg

3601 gtaaaaggaa gacagtactt aattatgggt aaagaagccc tccagataaa atacaatttc

3661 agtttcaggt acatctaccc tttagattcc ttgacctgga ttgaatactg gcctagagac

3721 acaacatgtt catcgtgtca agcattttta gctaatttag atgaatttgc cgaagatatc

3781 tttttaaatg gatgctaaaa ttcctgaagt tcagctgcat acagtttgca cttatggact

3841 cctgttgttg aagttcgttt ttttgttttc ttcttttttt aaacattcat agctggtctt

3901 atttgtaaag ctcactttac ttagaattag tggcacttgc ttttattaga gaatgatttc

3961 aaatgctgta actttctgaa ataacatggc cttggagggc atgaagacag atactcctcc

4021 aaggttattg gacaccggaa acaataaatt ggaacacctc ctcaaaccta ccactcagga

4081 atgtttgctg gggccgaaag aacagtccat tgaaagggag tattacaaaa acatggcctt

4141 tgcttgaaag aaaataccaa ggaacaggaa actgatcatt aaagcctgag tttgctttc

1 ctacctccaa ccatgggcct tttgggaata ctttgttttt taatcttcct ggggaaaacc

61 tggggacagg agcaaacata tgtcatttca gcaccaaaaa tattccgtgt tggagcatct

121 gaaaatattg tgattcaagt ttatggatac actgaagcat ttgatgcaac aatctctatt

181 aaaagttatc ctgataaaaa atttagttac tcctcaggcc atgttcattt atcctcagag

241 aataaattcc aaaactctgc aatcttaaca atacaaccaa aacaattgcc tggaggacaa

301 aacccagttt cttatgtgta tttggaagtt gtatcaaagc atttttcaaa atcaaaaaga

361 atgccaataa cctatgacaa tggatttctc ttcattcata cagacaaacc tgtttatact

421 ccagaccagt cagtaaaagt tagagtttat tcgttgaatg acgacttgaa gccagccaaa

481 agagaaactg tcttaacctt catagatcct gaaggatcag aagttgacat ggtagaagaa

541 attgatcata ttggaattat ctcttttcct gacttcaaga ttccgtctaa tcctagatat

601 ggtatgtgga cgatcaaggc taaatataaa gaggactttt caacaactgg aaccgcatat

661 tttgaagtta aagaatatgt cttgccacat ttttctgtct caatcgagcc agaatataat

721 ttcattggtt acaagaactt taagaatttt gaaattacta taaaagcaag atatttttat

781 aataaagtag tcactgaggc tgacgtttat atcacatttg gaataagaga agacttaaaa

841 gatgatcaaa aagaaatgat gcaaacagca atgcaaaaca caatgttgat aaatggaatt

901 gctcaagtca catttgattc tgaaacagca gtcaaagaac tgtcatacta cagtttagaa

961 gatttaaaca acaagtacct ttatattgct gtaacagtca tagagtctac aggtggattt

1021 tctgaagagg cagaaatacc tggcatcaaa tatgtcctct ctccctacaa actgaatttg

1081 gttgctactc ctcttttcct gaagcctggg attccatatc ccatcaaggt gcaggttaaa

1141 gattcgcttg accagttggt aggaggagtc ccagtaatac tgaatgcaca aacaattgat

1201 gtaaaccaag agacatctga cttggatcca agcaaaagtg taacacgtgt tgatgatgga

1261 gtagcttcct ttgtgcttaa tctcccatct ggagtgacgg tgctggagtt taatgtcaaa

1321 actgatgctc cagatcttcc agaagaaaat caggccaggg aaggttaccg agcaatagca

1381 tactcatctc tcagccaaag ttacctttat attgattgga ctgataacca taaggctttg

1441 ctagtgggag aacatctgaa tattattgtt acccccaaaa gcccatatat tgacaaaata

1501 actcactata attacttgat tttatccaag ggcaaaatta tccattttgg cacgagggag

1561 aaattttcag atgcatctta tcaaagtata aacattccag taacacagaa catggttcct

1621 tcatcccgac ttctggtcta ttatatcgtc acaggagaac agacagcaga attagtgtct

1681 gattcagtct ggttaaatat tgaagaaaaa tgtggcaacc agctccaggt tcatctgtct

1741 cctgatgcag atgcatattc tccaggccaa actgtgtctc ttaatatggc aactggaatg

1801 gattcctggg tggcattagc agcagtggac agtgctgtgt atggagtcca aagaggagcc

1861 aaaaagccct tggaaagagt atttcaattc ttagagaaga gtgatctggg ctgtggggca

1921 ggtggtggcc tcaacaatgc caatgtgttc cacctagctg gacttacctt cctcactaat

1981 gcaaatgcag atgactccca agaaaatgat gaaccttgta aagaaattct caggccaaga

2041 agaacgctgc aaaagaagat agaagaaata gctgctaaat ataaacattc agtagtgaag

2101 aaatgttgtt acgatggagc ctgcgttaat aatgatgaaa cctgtgagca gcgagctgca

2161 cggattagtt tagggccaag atgcatcaaa gctttcactg aatgttgtgt cgtcgcaagc

2221 cagctccgtg ctaatatctc tcataaagac atgcaattgg gaaggctaca catgaagacc

2281 ctgttaccag taagcaagcc agaaattcgg agttattttc cagaaagctg gttgtgggaa

2341 gttcatcttg ttcccagaag aaaacagttg cagtttgccc tacctgattc tctaaccacc

2401 tgggaaattc aaggcattgg catttcaaac actggtatat gtgttgctga tactgtcaag

2461 gcaaaggtgt tcaaagatgt cttcctggaa atgaatatac catattctgt tgtacgagga

2521 gaacagatcc aattgaaagg aactgtttac aactatagga cttctgggat gcagttctgt EPI-109 849

2581 gttaaaatgt ctgctgtgga gggaatctgc acttcggaaa gcccagtcat tgatcatcag 2641 ggcacaaagt cctccaaatg tgtgcgccag aaagtagagg gctcctccag tcacttggtg 2701 acattcactg tgcttcctct ggaaattggc cttcacaaca tcaatttttc actggagact 2761 tggtttggaa aagaaatctt agtaaaaaca ttacgagtgg tgccagaagg tgtcaaaagg 2821 gaaagctatt ctggtgttac tttggatcct aggggtattt atggtaccat tagcagacga 2881 aaggagttcc catacaggat acccttagat ttggtcccca aaacagaaat caaaaggatt 2 41 ttgagtgtaa aaggactgct tgtaggtgag atcttgtctg cagttctaag tcaggaaggc 3001 atcaatatcc taacccacct ccccaaaggg agtgcagagg cggagctgat gagcgttgtc 3061 ccagtattct atgtttttca ctacctggaa acaggaaatc attggaacat ttttcattct 3121 gacccattaa ttgaaaagca gaaactgaag aaaaaattaa aagaagggat gttgagcatt 3181 atgtcctaca gaaatgctga ctactcttac agtgtgtgga agggtggaag tgctagcact 3241 tggttaacag cttttgcttt aagagtactt ggacaagtaa ataaatacgt agagcagaac 3301 caaaattcaa tttgtaattc tttattgtgg ctagttgaga attatcaatt agataatgga 3361 tctttcaagg aaaattcaca gtatcaacca ataaaattac agggtacctt gcctgttgaa 3421 gcccgagaga acagcttata tcttacagcc tttactgtga ttggaattag aaaggctttc 3481 gatatatgcc ccctggtgaa aatcgacaca gctctaatta aagctgacaa ctttctgctt 3541 gaaaatacac tgccagccca gagcaccttt acattggcca tttctgcgta tgctctttcc 3601 ctgggagata aaactcaccc acagtttcgt tcaattgttt cagctttgaa gagagaagct 3661 ttggttaaag gtaatccacc catttatcgt ttttggaaag acaatcttca gcataaagac 3721 agctctgtac ctaacactgg tacggcacgt atggtagaaa caactgccta tgctttactc 3781 accagtctga acttgaaaga tataaattat gttaacccag tcatcaaatg gctatcagaa 3841 gagcagaggt atggaggtgg cttttattca acccaggaca ccatcaatgc cattgagggc

3goι ctgacggaat attcactcct ggttaaacaa ctccgcttga gtatggacat cgatgtttct

3961 tacaagcata aaggtgcctt acataattat aaaatgacag acaagaattt ccttgggagg

4021 ccagtagagg tgcttctcaa tgatgacctc attgtcagta caggatttgg cagtggcttg

4081 gctacagtac atgtaacaac tgtagttcac aaaaccagta cctctgagga agtttgcagc

4141 ttttatttga aaatcgatac tcaggatatt gaagcatccc actacagagg ctacggaaac

4201 tctgattaca aacgcatagt agcatgtgcc agctacaagc ccagcaggga agaatcatca

4261 tctggatcct ctcatgcggt gatggacatc tccttgccta ctggaatcag tgcaaatgaa

4321 gaagacttaa aagcccttgt ggaaggggtg gatcaactat tcactgatta ccaaatcaaa

4381 gatggacatg ttattctgca actgaattcg attccctcca gtgatttcct ttgtgtacga

4441 ttccggatat ttgaactctt tgaagttggg tttctcagtc ctgccacttt cacagtttac

4501 gaataccaca gaccagataa acagtgtacc atgttttata gcacttccaa tatcaaaatt

4561 cagaaagtct gtgaaggagc cgcgtgcaag tgtgtagaag ctgattgtgg gcaaatgcag

4621 gaagaattgg atctgacaat ctctgcagag acaagaaaac aaacagcatg taaaccagag

4681 attgcatatg cttataaagt tagcatcaca tccatcactg tagaaaatgt ttttgtcaag

4741 tacaaggcaa cccttctgga tatctacaaa actggggaag ctgttgctga gaaagactct

4801 gagattacct tcattaaaaa ggtaacctgt actaacgctg agctggtaaa aggaagacag

4861 tacttaatta tgggtaaaga agccctccag ataaaataca atttcagttt caggtacatc

4921 taccctttag attccttgac ctggattgaa tactggccta gagacacaac atgttcatcg

4981 tgtcaagcat ttttagctaa tttagatgaa tttgccgaag atatcttttt aaatggatgc

5041 taaaattcct gaagttcagc tgcatacagt ttgcacttat ggactcctgt tgttgaagtt

5101 cgtttttttg ttttcttctt tttttaaaca ttcatagctg gtcttatttg taaagctcac

5161 tttacttaga attagtggca cttgctttta ttagagaatg atttcaaatg ctgtaacttt

5221 ctgaaataac atggccttgg agggcatgaa gacagatact cctccaaggt tattggacac

5281 cggaaacaat aaattggaac acctcctcaa acctaccact caggaatgtt tgctggggcc

5341 gaaagaacag tccattgaaa gggagtatta caaaaacatg gcctttgctt gaaagaaaat

5401 accaaggaac aggaaactga tcattaaagc ctgagtttgc tttc

1 ctacctccaa ccatgggcct tttgggaata ctttgttttt taatcttcct ggggaaaacc

61 tggggacagg agcaaacata tgtcatttca gcaccaaaaa tattccgtgt tggagcatct

121 gaaaatattg tgattcaagt ttatggatac actgaagcat ttgatgcaac aatctctatt

181 aaaagttatc ctgataaaaa atttagttac tcctcaggcc atgttcattt atcctcagag

241 aataaattcc aaaactctgc aatcttaaca atacaaccaa aacaattgcc tggaggacaa

301 aacccagttt cttatgtgta tttggaagtt gtatcaaagc atttttcaaa atcaaaaaga

361 atgccaataa cctatgacaa tggatttctc ttcattcata cagacaaacc tgtttatact

421 ccagaccagt cagtaaaagt tagagtttat tcgttgaatg acgacttgaa gccagccaaa

481 agagaaactg tcttaacctt catagatcct gaaggatcag aagttgacat ggtagaagaa

541 attgatcata ttggaattat ctcttttcct gacttcaaga ttccgtctaa tcctagatat

601 ggtatgtgga cgatcaaggc taaatataaa gaggactttt caacaactgg aaccgcatat

661 tttgaagtta aagaatatgt cttgccacat ttttctgtct caatcgagcc agaatataat

721 ttcattggtt acaagaactt taagaatttt gaaattacta taaaagcaag atatttttat

781 aataaagtag tcactgaggc tgacgtttat atcacatttg gaataagaga agacttaaaa

841 gatgatcaaa aagaaatgat gcaaacagca atgcaaaaca caatgttgat aaatggaatt

901 gctcaagtca catttgattc tgaaacagca gtcaaagaac tgtcatacta cagtttagaa

961 gatttaaaca acaagtacct ttatattgct gtaacagtca tagagtctac aggtggattt

1021 tctgaagagg cagaaatacc tggcatcaaa tatgtcctct ctccctacaa actgaatttg

1081 gttgctactc ctcttttcct gaagcctggg attccatatc ccatcaaggt gcaggttaaa

1141 gattcgcttg accagttggt aggaggagtc ccagtaatac tgaatgcaca aacaattgat EPI-109 850

1201 gtaaaccaag agacatctga cttggatcca agcaaaagtg taacacgtgt tgatgatgga 1261 gtagcttcct ttgtgcttaa tctcccatct ggagtgacgg tgctggagtt taatgtcaaa 1321 actgatgctc cagatcttcc agaagaaaat caggccaggg aaggttaccg agcaatagca 1381 tactcatctc tcagccaaag ttacctttat attgattgga ctgataacca taaggctttg 1441 ctagtgggag aacatctgaa tattattgtt acccccaaaa gcccatatat tgacaaaata 1501 actcactata attacttgat tttatccaag ggcaaaatta tccattttgg cacgagggag 1561 aaattttcag atgcatctta tcaaagtata aacattccag taacacagaa catggttcct 1621 tcatcccgac ttctggtcta ttatatcgtc acaggagaac agacagcaga attagtgtct 1681 gattcagtct ggttaaatat tgaagaaaaa tgtggcaacc agctccaggt tcatctgtct 1741 cctgatgcag atgcatattc tccaggccaa actgtgtctc ttaatatggc aactggaatg 1801 gattcctggg tggcattagc agcagtggac agtgctgtgt atggagtcca aagaggagcc 1861 aaaaagccct tggaaagagt atttcaattc ttagagaaga gtgatctggg ctgtggggca 1921 ggtggtggcc tcaacaatgc caatgtgttc cacctagctg gacttacctt cctcactaat 1981 gcaaatgcag atgactccca agaaaatgat gaaccttgta aagaaattct caggccaaga 2041 agaacgctgc aaaagaagat agaagaaata gctgctaaat ataaacattc agtagtgaag 2101 aaatgttgtt acgatggagc ctgcgttaat aatgatgaaa cctgtgagca gcgagctgca 2161 cggattagtt tagggccaag atgcatcaaa gctttcactg aatgttgtgt cgtcgcaagc 2221 cagctccgtg ctaatatctc tcataaagac atgcaattgg gaaggctaca catgaagacc 2281 ctgttaccag taagcaagcc agaaattcgg agttattttc cagaaagctg gttgtgggaa 2341 gttcatcttg ttcccagaag aaaacagttg cagtttgccc tacctgattc tctaaccacc 2401 tgggaaattc aaggcattgg catttcaaac actggtatat gtgttgctga tactgtcaag 2461 gcaaaggtgt tcaaagatgt cttcctggaa atgaatatac catattctgt tgtacgagga 2521 gaacagatcc aattgaaagg aactgtttac aactatagga cttctgggat gcagttctgt 2581 gttaaaatgt ctgctgtgga gggaatctgc acttcggaaa gcccagtcat tgatcatcag 2641 ggcacaaagt cctccaaatg tgtgcgccag aaagtagagg gctcctccag tcacttggtg 2701 acattcactg tgcttcctct ggaaattggc cttcacaaca tcaatttttc actggagact 2761 tggtttggaa aagaaatctt agtaaaaaca ttacgagtgg tgccagaagg tgtcaaaagg 2821 gaaagctatt ctggtgttac tttggatcct aggggtattt atggtaccat tagcagacga 2881 aaggagttcc catacaggat acccttagat ttggtcccca aaacagaaat caaaaggatt 2941 ttgagtgtaa aaggactgct tgtaggtgag atcttgtctg cagttctaag tcaggaaggc 3001 atcaatatcc taacccacct ccccaaaggg agtgcagagg cggagctgat gagcgttgtc 3061 ccagtattct atgtttttca ctacctggaa acaggaaatc attggaacat ttttcattct 3121 gacccattaa ttgaaaagca gaaactgaag aaaaaattaa aagaagggat gttgagcatt 3181 atgtcctaca gaaatgctga ctactcttac agtgtgtgga agggtggaag tgctagcact 3241 tggttaacag cttttgcttt aagagtactt ggacaagtaa ataaatacgt agagcagaac 3301 caaaattcaa tttgtaattc tttattgtgg ctagttgaga attatcaatt agataatgga 3361 tctttcaagg aaaattcaca gtatcaacca ataaaattac agggtacctt gcctgttgaa 3421 gcccgagaga acagcttata tcttacagcc tttactgtga ttggaattag aaaggctttc 3481 gatatatgcc ccctggtgaa aatcgacaca gctctaatta aagctgacaa ctttctgctt 3541 gaaaatacac tgccagccca gagcaccttt acattggcca tttctgcgta tgctctttcc 3601 ctgggagata aaactcaccc acagtttcgt tcaattgttt cagctttgaa gagagaagct 3661 ttggttaaag gtaatccacc catttatcgt ttttggaaag acaatcttca gcataaagac 3721 agctctgtac ctaacactgg tacggcacgt atggtagaaa caactgccta tgctttactc 3781 accagtctga acttgaaaga tataaattat gttaacccag tcatcaaatg gctatcagaa 3841 gagcagaggt atggaggtgg cttttattca acccaggaca ccatcaatgc cattgagggc 3901 ctgacggaat attcactcct ggttaaacaa ctccgcttga gtatggacat cgatgtttct 3961 tacaagcata aaggtgcctt acataattat aaaatgacag acaagaattt ccttgggagg 4021 ccagtagagg tgcttctcaa tgatgacctc attgtcagta caggatttgg cagtggcttg 4081 gctacagtac atgtaacaac tgtagttcac aaaaccagta cctctgagga agtttgcagc 4141 ttttatttga aaatcgatac tcaggatatt gaagcatccc actacagagg ctacggaaac 4201 tctgattaca aacgcatagt agcatgtgcc agctacaagc ccagcaggga agaatcatca 4261 tctggatcct ctcatgcggt gatggacatc tccttgccta ctggaatcag tgcaaatgaa 4321 gaagacttaa aagcccttgt ggaaggggtg gatcaactat tcactgatta ccaaatcaaa 4381 gatggacatg ttattctgca actgaattcg attccctcca gtgatttcct ttgtgtacga 4441 ttccggatat ttgaactctt tgaagttggg tttctcagtc ctgccacttt cacagtttac 4501 gaataccaca gaccagataa acagtgtacc atgttttata gcacttccaa tatcaaaatt 4561 cagaaagtct gtgaaggagc cgcgtgcaag tgtgtagaag ctgattgtgg gcaaatgcag 4621 gaagaattgg atctgacaat ctctgcagag acaagaaaac aaacagcatg taaaccagag 4681 attgcatatg cttataaagt tagcatcaca tccatcactg tagaaaatgt ttttgtcaag 4741 tacaaggcaa cccttctgga tatctacaaa actggggaag ctgttgctga gaaagactct 4801 gagattacct tcattaaaaa ggtaacctgt actaacgctg agctggtaaa aggaagacag 4861 tacttaatta tgggtaaaga agccctccag ataaaataca atttcagttt caggtacatc 4921 taccctttag attccttgac ctggattgaa tactggccta gagacacaac atgttcatcg 4981 tgtcaagcat ttttagctaa tttagatgaa tttgccgaag atatcttttt aaatggatgc 5041 taaaattcct gaagttcagc tgcatacagt ttgcacttat ggactcctgt tgttgaagtt 5101 cgtttttttg ttttcttctt tttttaaaca ttcatagctg gtcttatttg taaagctcac 5161 tttacttaga attagtggca cttgctttta ttagagaatg atttcaaatg ctgtaacttt 5221 ctgaaataac atggccttgg agggcatgaa gacagatact cctccaaggt tattggacac EPI-109 851

5281 cggaaacaat aaattggaac acctcctcaa acctaccact caggaatgtt tgctggggcc 5341 gaaagaacag tccattgaaa gggagtatta caaaaacatg gcctttgctt gaaagaaaat 5401 accaaggaac aggaaactga tcattaaagc ctgagtttgc tttc

(2) INFORMATION FOR SEQ ID NO: 2672: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2672

1 aagcttcagt atgcaaattt tcaatgacat gtgcctgtgg attctgaaaa ttcacagatc

61 tgtctatcct tagctgagac tgaaggcatc tacttcccaa tgaccaaatc ctggtgctgt

121 ggcgacactg agcaggaact ccattagaat atcaatatca ctctgcagac attccatgat

181 gtaagctatg ttttctcttg ttgcaattac acttaattta ccaccagctg cttcaatgtc

241 atgggctatc ttgaaaaatg aagctccttt cgtagtcaaa ctggatgcaa gacacagcaa

301 atgagaagtt actaaattgt tggagtcctc atagctactg cctgctttaa tgaacaaacc

361 aattcttgat gcagggcata gttttccaaa ggagaaatca taaaaccatt tggaaatttg

421 atgatctcaa ggtcctgatg atgtggagcc actcctatgg gggtagctgt ggctttaact

481 ttgggggcaa ctttgaggga ataaagtctc aaaaagaggg aataaagtct caagattgtt

541 cgtgacccat agtaacttct ggcttaaagg accattcggc aagtttttaa atgtattttc

601 tataatttcc atgtagttct ttatattttc tatttcttat ttaaaacctc tattttagct

661 cgtttccttt gacactgctc tggcagggaa aggggtggca ctgcctcatt actgccaggt

721 aggggtagaa gtccattatc cacttggtct ccattgatac ccaaagtggg gagaggctcc

781 tgttactgct ggtgagggtg ggagtccccc cactaagttt ctgctaatac tgtcctggtg

841 gcttgctact attcccatga agcctccact gatactacat tacttttggg tggtggcaaa

901 tgtcctgcct ctccactagc cctcctgctc taaaacaacc cgagtaggga gtgggaagga

961 agctttgtta ctggtaggtg ggagctgaag tccagacttg ccacattgtc ccactgatgc

1021 tacagggagg aggaagcggg ccacattact gcctgatagg gatgaaagcc ccagctccct

1081 acctggcctt cgctgatacc agcctgctac aggagtgaag agagatttga aggcctcaat

1141 atagcctgtc gagggtggaa gtcttgctcc caatgggcct ttagcagcat gggtgggtgt

1201 ggggccatag ctgtctctgt actgcttggc tagagtggag tatttgaggt ccaaaagttt

1261 tctgtctttc tagccctttg gttagaaaga gcagactttt gttggaagta tttttttgtg

1321 tttacctgtt gtatttccag gttcctagct tctccagcac agtctgggat gtgtgagaca

1381 cagagaaaat ccagtgatgt tactaccgta tggtttcttg ggtcccaacg tctctagcta

1441 atctgctcca ccttttggag ttttcttatt tgttttagat cagggattta gtcatattta

1501 ataggagaaa tatggaaaaa tacttctact ctatcttcct ggaagttcct gtttattttt

1561 tatgtccttt tcctctggct agaccgtaag agacttacga aacaaacact tacacattct

1621 actaaactca atgtccaaag tttgtgaact tcttgaatat tgcttgttca tttccacccc

1681 cagtcactga ctgaatctcc ctgctgtctg tctacaatgc caatgagctt ctggttaact

1741 tcttctcatg catgcttagg caacaacttc ccagttttac tacacttgcc catccctagt

1801 tttgttgttg cttaatccct tggcctagtg ccaccatact cctccagcag agcaaccaat

1861 tcttacatta taggacagca catatccact aaaaacagtt catgccacac caaccacatt

1921 tccctttgtc aacaaaatta cttgatagat aattccagga atgcctgatg aagctgattg

1981 acaacaagat atttggcaga ctctctgctg cctatacata ccttagcatg tggaactcaa

2041 gtaatgagag gtccatttaa ttggattgaa ttgggctgga taggattgga ttgaatcctg

2101 tgggatggct aggctaaatt agaaatgaag actagtttaa cagcagtatc caaggatagt

2161 tgactaatga gttaatttta ctctcaaaga cagtctttag tagtaagctg taatgcatta

2221 tatcaaacta ttttccagtc aatgatttat aagttacttg aataaggatg ctaaagatgt

2281 gccttattga aatggcaatt agcacaaagt tgggaatgaa atctaattag ttaaataaca

2341 gaatcacata aaaaaggact tgaataaatg tagcatccta ccatgttcct ggatagaaag

2401 actgctatcg taaagatatt cattctcctc aggttaaatt ataaactcaa tgcaattcaa

2461 caggatttta aaaaactaga caaagtgatt ccaagtttac gtggaaaata aaatgtgagg

2521 gaccaaacaa tatttgaaaa agaaagagaa taaaatctca tccttccaga taccacaatg

2581 tattataaag caatagtaat taacatgagg gcagaaatga gcaagcaagt gaacaaaata

2641 agacagatag tcacaggaaa ctcatatatt tataggtgct ttgcgtataa tgaagatggt

2701 ccttcaaatc agttgggaaa agatgggtta ttcaataaat ggtgttgggt aaaattggtt

2761 atacattggt gagaaataaa gtgaaactcc tactttgtat catatgcaaa aaatagattc

2821 cagacagatg aaatatttaa atgtaaaaaa taaaattcta aaactactag aaaaaaaaga

2881 agaatatttt tattcctttg aaatagaaaa ggtcttacta agcaaaacac agaagtaata

2941 aatgaataaa tgaagacaaa tatgataaaa ataagttaaa aatataagca atctttcttt

3001 gttttttttt cacctttcct agaaaaaaat atataggcaa cttgttaagc aaggtagatt

3061 acaagaaaat atttacaaca tttgacaggc cacagattat tatccagcct catctgataa

3121 gaaaacttca acataaagat atctgttttt tttcttataa ggttcctcaa agtgagccaa

3181 tcacttctta agctgaacaa aaaacaaaac agaagtgatc ttttccaata atgaaaacaa

3241 acattgacag agcagctgta ggatcctttc aggcaaatta tgaaaaggtg ccctttctca

3301 gaaaccacag ttaccattca gctttgtgac cagaggtttg actgtaccct agtccctact

3361 agcaacccaa ccacataacc aacttcaaag gtcctgaatg actgtgttgt acttaatggc

3421 agatgatcta tctcccattt ttgtcctaag gattttccaa gataatatat ttctgcattt

3481 gttttgcttt tacttcactc caaattgaaa tctatttgtg ggataagact aaagaaatgc

3541 ttataggaaa attgatagca ccaaattcct atcttaaaaa atgaaaaagg tttcaaatca

3601 atgacctcag cttttacttt aagaaaatag aaaaagcagg ataagctaaa gccaaagtaa

3661 acagaagaaa ggaaattata aagataagag cagaaatcaa tgaatagaaa acaaaagaaa

3721 aaaatcaaac caaacagctg attctttaag cagatctata aaattgataa aactctagcc

3781 agattgatca agtaaaaaag agagaagaca caaattacca gtattaagaa tgagagaggc EPI-109 852

3841 aatatcacta cagatcctac agatataaaa agtataaggg catactttga ataattttat 3901 gactataaat taggcaactt agataaaaca aatttcttga aagacacaaa caaccaaagc 3961 tcacctaaaa tactcacaaa ttgaatagtc ttatagctat tacaaaattg aggccaggcg 4021 cagtggctca agcctttaat cccagcactt tgggagggct aggaaggcgg atcacgaggt 4081 caggagtttg agaccagcct gactaacatg gtgaaaccct gtctctacta aaagtacaaa 4141 aattagccag gcttggtgg^'t gcgtgcctgt aatcccatct actcaggaga ctgaggcagg 4201 agaattgctt gaacctggga ggcaaagttg tggtgagccg agatcgcgcc actgcacttc 4261 agcctgggca acagaacaag actccgtctc aaaaaaaaaa aaaaaaaaaa aaattgaaat 4321 tatagttaaa agtcttccca caaagcaaac tctagaccca gatggcttca atggtaaatt 4381 ctactggaca atcaaacagg aaacagtaat aattctccac aatgtctttc ataaaattga 4441 tgcggaggag atactctcca actcattcta tgaaactagc attaccctga taccaaaatc 4501 atacagagac agtgtaggaa aacaacagat cagtatcctt catgaacata aatgaagtac 4561 aatgcagtct tatgcataaa tcagagcttc attgttctac agataaggta atgtaggatt 4621 gttggttgcc cctccaggtc tgttaaattc acctccttcc ccagagagca tccttcttaa 4681 ggacagggag cctcaatatg tcagtcctca cagcacctcc ctcagtcttc agcacttacc 4741 agctcatcac cacaaccgat accacattgg ataatttcat gaattacttt agagcaaatg 4801 caagagaaaa aatggatttt tatataggag aagaaggagg aaattcttgt ggatttggta 4861 cagaataggg ccaagggaaa attacagatg taaaaagaaa agtgtgtgaa atagtatcct 4921 tagtgctcac aaatacaatg atttcattgt ttttaaaaat aaaaaatgac aaatgtctaa 4981 tgcttggtgg taatgcttta ttgaatgtgt gttatacact ggttcctcat tcctgaagtt 5041 agaaataata ccttcctctt ttcatttggt tatgtttgct gaaacaaatc aaaggctgag 5101 attgaaacac atgctacttc aggtggatga ccttactact aagctcatca caacagcact 5161 tacagctgaa gaccccagag tcctacctaa cttttgtcac aacccagatt ttggccatgt 5221 agttctgggc cttaccatta aagcagacag aagtcagagg aatgactcct ttccacttga 5281 agtgagctgc aggcttctag gaaaggcaag atgcacattt ccctcctgtg gagcataaag 5341 cctttgtaat tcaggactta ggacccatat ggatttgaaa tattatgaca ttggagctgg 5401 agtggttggg gacaacacca gtagtgttat aggccatgga atgtcaaaag aacatggaac 5461 cctgttaaaa tcattaaaca tcaaaactct cccctcctct ggtgatatgg tttggctgtg 5521 tccccatcca aatctcatct tgaactccca tgtgttgtgg gaggcaccca gtgggaggta 5581 attgaatcat gggggcaggt ctttcccatg ctgttttcac gatactgaat aagtctcaca 5641 agatctgatg gttttataaa ggggagcttc cctgcacaag ctctcttctc ttgtctgcca 5701 ccatgtgaga catgcctttc accttccgcc atgattgtga ggcctcccca accatgtgga 5761 acttttaagt tcattaaacc tcttcctttt gtaaattgct cagtctcaaa tatgtcttta 5821 tcagcaacgt gaaaacagac tatctgattt tctgtgggat gtggattatg accatggaca 5881 gagcataact gggacagagc tggaaaaaat attaattagg tgcttaaaaa tatttgttag 5941 aactatcttc atgaatgaga atcaatcctg tttccatggt gattcaccag gcatcaattc 6001 caagcatcca tgaatcagaa aagtcctatc ttctcttagt tatcatccag gactccaagg 6061 aaccataatt agccaacctg ttcacatttc cttttcattc actagcctcg aagtttccag 6121 gggacaggga ctctgtccta ttcatttctg taaccttacc acctgaccca gaatagctgt 6181 tccctgaaga tttggtggat tataaatgtg gatgtcttat ttctttgaaa gtgtgagctt 6241 caggtactga tcacgttatt ccaattatca atttagtatc tttcttcacc attaaactgt 6301 gaaattcttg agggaagaac ctatgactga tttatctctg taaactcatg ccaccagtat 6361 tcaaaatcac acctagcaca tagtaaacac tcaatgtttg ttgaatgact gaaggaatgg 6421 atgaaaatga acctccttgc ttctgaccag tggatgagtt gcttggccgt gttcctacag 6481 cctagagctc atcccctaaa gcatctgaag ttacccatta gtgcaatggt tcttgaacgc 6541 tggtgttgat cagaatcatc tggatgccca ggttctctga aataagatag ggtctaggca 6601 tttgtatttt taccaaggag gtgtgatgga gtcagatgca agaaggctag ttgaagaaac 6661 cacatgagag tttagtgtag tgtattagaa gactggtttg gctctgtcgc tagtggctac 6721 atcatcttgc tcaagtcatg ccagtctcag gacctcattc agtctcttca gctgtaatat 6781 gggtgggttg caccacataa ccagaaagat cccttccagc tctacccact tacaacatgg 6841 tcaaatttgg tctgattttt taaatcgtag tacaatatat atgacataaa attcaccatt 6901 ttagccactt taaatgtaca attctgtagc attaactaca ttcacattgt tgtgcaacca 6961 tcactaccgt ctacttccag aactcttcat cttgcaaaac tgaacctctg ttgtcattag 7021 tcactaacta ttcctctccc cccctccttc taggccctgg caatcaccat tctactttct 7081 gtcgctatga atttgactac tctaggtaac ttatataagt ggaatcacag catttgccct 7141 attatgactg gtttagttga cttagcacaa cctcctaagg ctcaaccaca ttttagcatg 7201 tgtcagaatt ttctttgttt ttaaggctga ataatattct gttgtatctg taaataacat 7261 ctttattcat ttgtccatca acagactgtt gagttcctcc catcttttga ctattgtgaa 7321 aaatgctgct atgaacctga gtgtacagac atctggttga gtactgcttt caattcattg 7381 tttatatgga tcatatggta attttatgtt taattttttt ggaactgcta cattgttttc 7441 cacagtgtac atcattttac atttccatca gcaatgcaca aaggttccaa tttctccaca 7501 ttcttaccaa cattttttat tttctgtttc ttatttattt gtttatttat tctgagacag 7561 agtctcactc tgtcacctag gctggagtgc agcagggtga tctcagctca ctgcaacctc 7621 tgcctcccat gttcaagtga ttctcctccc tcagcctccc aagtaaatgg aattacaggt 7681 gcccaccacc acgcccaggt aatttttgca ttttttttag tagtgatgag gtttcaccat 7741 gttggtcagg ctggtcttga actcctgacc tcaagtgatc cacccgcctc agcctcccaa 7801 agtgctggga ttacaggtat gaaccactgc acccaggcca ttttttgctt tttagataat 7861 agtcatccta gtgggtatga agtggtattt cattgtggtt ttgatttata tttccctaat 7921 gatcagtgat attgagcatc tttcaagtgc ttattggcca ttttcttctt tggagaaatg 7981 tctatgcaag tcctttgctc attttttaat ccagttgctt tttgttattc tttttgattt 8041 gaaagtgttc tttatacctc ttgtatacta atcccttatc agatatgatt tataaatatt 8101 ttcttctttt ccatggattg ccctttttac tctgttgata gtgttctttg atacaaaata 8161 atttttaatt tgaatgaagc ccaattaatc tatttttgtt tcttttgttg cctgtgcttt 8221 tggtgtccta tccaagaaac tgttgccaaa tccaatgtca taaagctttt tcccatgctt 8281 ccttctaaga gttttgtagt tacagctctt gtatttaggt atttgactat tttgagttaa EPI-109 853

8341 tttttgtaca tcgtataaaa taagaatcca atttttattt tattttactt tttgtatgtg

8401 gatatccaat ttccccacca ccattcattg aaaagactgt ccttttccta tcgaatggtc

8461 ttggcaccct tgtaaaacat aatttgacca tatatgtgag ggtttatttc tgggctctct

8521 attctattct attctattct attctattct attctattct attctattct attctattct

8581 attggtccct atgtctttct ttattctagt accaccattt tgctcatcat aactttgtag

8641 taagttttga agtcaggaat cgtaagacct ccagctttgt tcattttcaa ggttgttttg

8701 attattcaag gtcccttgat agtccatatg aatttcagga tggatttttc tatttctgca

8761 aaaaaaaaaa aaaaaaaaaa aaaaatcatt gaaattttta aacagattgc attaaatctg

8821 tagattgttt tgggtagtat tgacatttaa caacattaaa tcttccaatc aatgaactag

8881 gctattttta tttatttttt ctgtttcttt gagctacttt tgtagttttc agtgtataag

8941 tttttgctac ctggttaggt atacttctaa gtattttcta ctttttgatg ctattgcaca

9001 ttgaatcgtt ttcttaattt ggtggtagcg gggattgtgc attgttagta cataaaaatg

9061 caactcattt tttgtgtgtt gattttgtat cctgcagctt taacaaattc atgttagttc

9121 taacagactt attctatgaa tcattagggt tttctacata aaagatcatg tcacctacaa

9181 acagagataa ttttactcca ccccttcccg ttgcaatgcc ttttatgtct ttttcttgcc

9241 taattgttct ggctaagact tccactacca tgttgaatag aagtggtgaa agtagacatc

9301 cttgtcttgt tccaatctta gagccaaagc tttcagtctt tcacggcctg aaagactttg

9361 taatatgttc tcaaggttaa agaacttcag aagttttcta agcaagagac cattttatta

9421 acttagttgg cagcaattct gagagattag aatgaaaaga tagaggataa gaagtatctg

9481 gcaggtataa tatattgagt gtgctgaata tacttttagt tttgtatagg tgttaaaaaa

9541 tggcaaagga ggccgggcgt ggtggctcac gcctgtaatc ccagcacttt gggaggccga

9601 ggcgggcaga tcatgaggtc aggagatcga gaccatcctg gctaaaacag tgaaacccta

9661 tctctactaa aaatacaaaa aactcgctgg gcatggtggt ggacacctgt agtcccagct

9721 actcgggagg ctgaggcagg agaatggtgt gaacctggaa ggtggagctt gcagtgagcc

9781 gagatcacgc cactgcactc cagcctgggc gacagagaga gactccgtct caaaagaaaa

9841 aaaaaatggc aaaggaaaga atgaaaaata aagcaaggtc ccagaagagg ccaaaaatct

9901 taatcaaaat tgactgaaca ttacggaatg aaatggtttt tcctttactc caattaacga

9961 cttcacaaga agattccatc ctcgtttata agattaaccc aaaaccagca cttaaaacca

10021 gaagccttga aaggatggag tttggggacc cttctcatgt ctattcccag aagggggtct

10081 tcttctgggg tcctgtcccc taaagagcta ggcaaaaagt atgcttgcca catctgttga

10141 aagatagaaa gttggtctaa aaatacatga gagggaactg aaacatttca gagaaggcaa

10201 gactcagaag taagaaacca aaagaggaag gtaaaattct agttacaaag aaaagaggaa

10261 tggaaattaa attgtcttac agagaaaatc cagaactgcc ccctcttccc ttactactcc

10321 atcaaaaaag gggaaaaata gtcaatggga aagttttgag aaaaatagat ctctgcattc

10381 ttctggttga gaattcagac aacttgaact agagagctgg gtaatttctt gactaaaggt

10441 gtgttagatc tgaaagggtt tttcttaaaa ttgtctgtgt tcatccctcc catcttagag

10501 aggaacacag gataagagac ctctggagct cccccagggt caccgagcta ataggatcag

10561 agacaaagct acaaagtcat tttctgacat ctctccaggg ctcttttttt ctggaccccc

10621 catatcaaca tgatgtattt attacattgg attagcaact ctccttgagc tttcctcagt

10681 accaggttta catctcagtc tgtgggtctc agagaaagta cccaatcagc agcaacatta

10741 cctggaaact catcagaagt gcccctcctc agccccaccc cagatctatg caatcagaaa

10801 ctctggaaat gcaggccagt cctaacaagc ccaccaggga attctggtgc actaaggttt

10861 gagatccact gatcaaagaa ataatattcc ttttcttcat tataatagca tgaataataa

10921 ctaacatgta tttcacaatt tacaaaagag ctttatgctc ttgttaaatt tgagggtagt

10981 cttctcaaaa tctctgtgag gctagaaagt cagatattga aacacctgtt ttatgggttc

11041 aaagataggt tcaaaagaga gtaaatgatt gttggggtgg caggtccaga gagggcagga

11101 tcaaaactgc aattgagtct tctgccttat aaaccagcat agcttcccca aggcacgtca

11161 cttctcgata aaatggtgac aactagagtg tcctttcaga tcattcttag aagcatggag

11221 tgctaggtca attgtgtaat tgatgaggaa ataataatac taagaactcc catcttctac

11281 gtccttatat acaatcctgt caggtagaag ctgagtctca gagagaacaa gttgccctcc

11341 caggaccacc aggtaagctc ggcatagctg tgcttagaat gtaggctgtc tggcttctgg

11401 gcttgcctgc ccagggaggc tttgtgggtt ctacttggtc atccagatca cagaggggca

11461 gcactgactc ctacccagtg ctcttgactg tacatctaat actttctact aagaaaaccc

11521 cttctcttta gaccaatggt tttcaaatct tggtgtgcat tggaatcacc tggaaagctt

11581 gttaaaacac agattgtccc accccaagag tttctgattc tgtaggctgg ggtggggacc

11641 catgaaagtg catttctaat aaggtcccaa gtgatgctga tgccaccagt gtgtggacaa

11701 ccctttgagt ggtgaagctc tggacaccct aatttgcaag gctaatcagg catatgtggc

11761 aaatgaatac gaactgaaat tctgactcca atatcttcac tgatattcct aatccatagc

11821 atacacacag tcccattcgt ttccctttta gcttttaatc tacatttatc ctttcttcct

11881 ctgccactgc cttctctcca gttagctcaa accaggtaac acataaccgc ctcctaactc

11941 atccgcccag ttggtttctt tggctttaat ctagacttct tatctccacc agatttgcct

12001 taccaaagca ccaatttctt aaggcagggt tagaattaaa aatcttctgt tcctcctcat

12061 tgcctaaaac tcctaaactt atgattcaag gtcttccatg accttcatgg accagtctaa

12121 cgttttagcc tgtcctaagt gacatgcctc caccacatac ttcatgcttt ccactttctt

12181 tctccatgtc tttgttcatg catttccatt tcttctacct gcgatgtcct ccttcgccat

12241^' ctctgtagat ttaaaaatcc tacagggctc atctcaaatg ccctttcctt catgaagcct

12301 ttcatgaaat ccccatcgag aggttttccc tcctctcagc tctccaaagc acagatgtct

12361 gcgtttgtgg ctattatctt acgttgtttt gtattaaaat ttctccagct ttacacattt

12421 gtcatcctct taaggacaaa catcttatta tggtcaatgt gaagctatag aggataattt

12481 aatgaaatat tccaagggct agtcattaca catgactgat ttatctctgt aaactcatcc

12541 acactcatcc acctgatttt gattggccaa gttaatgaat cagagaggaa aagatggtaa

12601 aaatataata aaaatctcct aggtagtctc acatcccaca gagccccagg taatgaaatg

12661 aggccctgag ataatacttt atgaacaata aaactccggg ttctattgac agtgaagcaa

12721 gacctgagag agaaggctaa attcccttgt gtctagctgc cacaatcttc tgagaataat

12781 ggcctttctt cccgtctgcc ttctgaatca taggcaaatt tttctctttg gtgatcccta EPI-109 854

12841 atacagaaag gggaagtcaa ataaaatata tacaaggaga aggattctgg gagacagagt 12901 ttcttgattc ccttctgcat gctcctcctc aaaagccttt atgagcttac cttacattta 12961 aattctttta aacaaggcat tatgtggtct ggtcttttcc agctccacac accttcacac 13021 tacattcccc ccagctaatt ctgctctggg aacactgacc ttcttttagt tctttgaaca 13081 cattgatttc tggtcaagat gactcagtaa cttcaacctt tgttgtgccc ttggtgctgt 13141 gaagatatag atatatatta accactgcac accagaaatc agaaatagca caacagagaa 13201 taaagtcatt gagccatctt ctgagctcca aaagacaaat tttctccaaa aagacaaatt 13261 caggctctaa aacaatacct taaggaacca gaagtggaat agaaaattaa ggtggtaagc 13321 agggctaaac cacatgcctg ttgagcccag gtttggaaga agacaatggc aggtaggaat 13381 gtggtttctg atgggtaata ggtactgttt tcatttactt tctgttgctt ataacagaat 13441 atctgaaact gggtgcttta taaagaaaag gaatttatgt cttgcagtta gggaaactga 13501 gaagtcaaaa gttgagggct gcaattgaca agtgccttct tgctggtggg gatactctga 13561 agagtcttga ggtggtatcg ggcataccac tctcagtgag gggactgagc atactaggtc 13621 aggtctttct tcctcctttt ataaagctat cagtcccact cttatgataa cccattaatc 13681 cattaactga ttagccaatt aatccatgaa tggattaatt cattcatgag ggcagagcct 13741 tcctgaccca aacacctctt aaagactcca cctctcaata ctgccacatg ggggattaaa 13801 tttcagcatg agtttttgat gagacaaata ttccaatgat agcagttatt aaaagtacat 13861 gcttgagaga aggggattgg agtcagcctc agtgcttaaa ctcaaaagct aggatgaggc 13921 tctaacactc ctgaaagaag gagttgctgc tggctcctta ccagggctat atcttttaca 13981 gagcaggaga cctaaagagg caggaggacc cggacatcgt ttggaaacca agcactaaaa 14041 caggccatct gttatacccc caatatcctc tcaggacaag tgttttgaac cactcacaca 14101 aggactagtc tgggcaagtg ggctagatga agaaaccaca aaatagctaa gtggggagag 14161 aaagaccaaa aatactattt tattcaaaat gaaaatacaa tccaaaattc catgattcat 14221 gaagaaatca aatggtatgt gttaggtggt tcttgcattg ctatagagaa atacctgaga 14281 ttgggtaatt tataaagaaa agaagtttaa ttggctcata attctgcagg cttcacagga 14341 agcatggtgc tggcatctgc tcagcttctg gagaggcccc aagaagattt gctcaaggca 14401 gaaggttaag ggagagctgg cacatcacat ggtgagaaag gaagctagag agagagtgca 14461 gggtgaggtg ccacaagtta ccacagccag atctcttgag aactcactta ctttcatgag 14521 gacagcacca agccataagg tgtagggagc caaagtccca tgggacatga ccaactcagc 14581 attccactgg aggctatatg atcaaacagc aaactgttta tcacgaatgc aggatgtgag 14641 caaactcaca actggtcctg ccaacagaag gtttgttgga ggcaatcact ccctggtgcc 14701 tgaggtaatc tactgcaaca tctagagaat gcagtcttgc aagcctactc tggacagggc 14761 agctggcacc ttattccatc ccccttctca ctatcttttt ttgcctaata aatacagagg 14821 gctgtgtaaa gctcagggcc cttgtccact agaggcaagt tgccccctga ccccttcttc 14881 caaatatact cttttgtctc ttgtctttta ttctcacatt tgcccccttt gttcagttcc 14941 actaggtccg tgcgggttat atactggtgc cctgagcagc aacagaatca ggctctcaac 15001 aagtgtcatc cgaacatggg actttgagga catgaacgaa gaaggtctgc tggagcagag 15061 gaacagaaat tgacaaggtg aacagggacc ctgggacgag tctgccagca gcggatataa 15121 ggtcagttac ctaaagaggt actgatcagt gccctaaaga gatactggga gcagtgcttt 15181 aaagaagtac tgggaatggg aaattttctg aatcagggta acaaggggaa gaatttgtct 15241 attaaagaaa aacattatgt gcagttgctt aaagttgtat tggaacagtc tggagcttag 15301 gttaatttgc agacactaac tatcacatgc gtccgtgtga agagagtcca ccaacaggct 15361 ttgtgtgggc aataaagctt tttaatcacc ttggtgcagg tgggctgagt ccaaaaaagg 15421 agtcagcaaa gggagataga ggtggggcag ttttatagga tttgggtagg tagtggaaag 15481 ttacagttaa aagtggttat ctcttgtggg cagaggcagg ggtcacaagg tgctgggtgg 15541 ggaaatcatg agactctttt tctgggacag gagtgtcaca aggtcaattg atcagttggg 15601 gtggggcagg aacaaatcgc aatggtggaa tgtcatcact taaggcagga actgactatt 15661 tcacttcttt tgtggttctt cagttgtttc gggccatctg gatgtatagt gcagctcaca 15721 ggggatatga tggcttaggt tgggctcaga gacctgacat tcctatcttt ttatattaat 15781 aagaaaaaca aaacaaaata gtggttaagt gttggggcag caaaaatttt ttggggtggt 15841 atgtagagat aaggggcaat gtttctcagg gctgcttcaa gcacgatcac ggtggtgtgg 15901 gaatctagag tgggagagat taagctgaag aaaaattttg gggaaagggg tgatattctg 15961 gggttgttag aaggagcatt tgtcatatag aatgatgatg gcctggatgt ggttttgtat 16021 gaattgagaa actaaacgga agacacaagg tccaaataag agaaggagaa aaacaggcat 16081 taaaggatta agaattggga ggacacagga catccaatta gagagtgccc aagggggtcc 16141 agtgtaatta tttgcctgga caatgagttt tggggctcta ttaggttgtc atataccagg 16201 ccagattgat ttaggtaaaa acaacactct tcatttaaaa tatacagagt cctccttttt 16261 tagcagtgag taagttgaga cctattcctg tcttcttata ttaataagta aaataaagca 16321 aaatagaggt gaagtgttgg tgtcatgagg ggaacaggaa gcagttcggt cctatttgca 16381 aattgatttt gggggggtaa agaaaactag tgtacctttg cctgtccaat taataagtag 16441 acacatgtag atggaggagc cacagaggaa gaagagaact ttgtaaggca aaactggaaa 16501 tgtaaaggga aaagatgaga gggagcacca aaagaggtgt cttgcaccca gactcaggga 16561 tctagtgaga gcagcagctg ttagaggttg taatggggat taatggggct actgggtaga 16621 gggggaggtt caacttttat ggtgtatgag aaagcgcata gtgtctacaa gcaacctttc 16681 attgctattc ataggattgg gtataagtaa acaagaaggg ggggctagga ggagagtctg 16741 aagaacaagg ggaaggtagc caaggatgga gtgaaatgta gggcaaatgt cttaaaggaa 16801 atgagaggtt ctaagaggag ggctagtggc ttgtaaccca catggaagag gttacgaaag 16861 gatgatagaa tggaatgagc ctgtgaggct ggaaggagga attttccttg gtccaagaac 16921 catttgcctt gtgtgggaag agtttgatag gtggaagttt cagtgggagg gtaggcggga 16981 gtgactgatg agaaggagaa aaactggcca taagggacag aagttggaat gctagctgct 17041 cctttagcta ccttatcagc ataagctttg ccctgagtga tgggatctga tgccttttga 17101 tggcgcttgc agtgaatgac cctagcttcc ttggaagtag agcagcttta agaagagttt 17161 ttatgaagaa ggcattaata atggaggacc ctcgtatagt gaggaaacct ctttcaggcc 17221 atataacaga atggaggtgg agaatatgga aggcatattt agagtcagta taaatactga 17281 cacacaatcc ttttgcaaga gtgagggctc gagttaaggc aatgagttcg gcttgctgag EPI-109 855

17341 agggagtgga gtggggcaga gtggtagcct caatgataga tgtgaaagat actatagcgt 17401 agcctgcctt tgctggtgag tggtgattag gcctagtgga actgccatca ataaaccaag 17461 tgtgatcaga gtgaggaaca ggaaagaagg aaatatggga aaatggagtg aatgctaggt 17521 ggatcagaga gatacagtca tggggatcag gtgtggtatc aggaataatg tgggaggcca 17581 gattgaagtc caggccagga acaatggtaa ttgtgggaga ctcaacaaag agtgagttca 17641 actgaaggag ccgggggagg gggagagcgg cagaaagtat atgcatcagg tgtgaggaag 17701 aaaatacatt ttgaaagtta tgagaactgt agagagtgag ttgatcatag tttgtgattt 17761 tgagggcctt taaaagtatt aaagcagtgg cagctgccac acacagacat gagagccagc 17821 ctaaaacagt aaggtcaatc tgtttagaca gaaaggctgc agggcactgt ccaagctctt 17881 gtgtaaggat tctgaccgca cagccttgta ctttggctgt gtgtaatgaa aagggttggg 17941 atgagttagg gagagctagt gtgggagtag cttctagggc tgtttttaag gaacataaag 18001 aggagtgggg aaaggattta ggatctatgg ggtcagctag gtttcctttt gtgagtttat 18061 gtaatggttt agtcaggatg gcaaaaccag gtatccaaag gtgaaagtac ccaaccatgt 18121 ctaggaagga aaggatttgt tgctttgtag aagggattgg ggtttgggag attagccgga 18181 cacagatcag gagggagagc acttgtattt ttatgaagaa ttatgccgat aggtaacgga 18241 tgaggaagaa atttgggctt tggaggggga tacacgatat tcccttgaga atagatgttg 18301 gaggagcagg agggtgtcct gttgggaaga ttcataggag gggctataaa gtagaaggcc 18361 atcaaaatat tgaataaggt gacaagcaga tggacagaaa agtaaattat gagaaagggc 18421 ttgactgaag taatggaggc tgtccctgaa gccttgtggc agtacagccc aggtaagttg 18481 ctgagactga tgggtgtcag ggtcagtcca agtgtaagtg aagagaggct ggggtgaaga 18541 gtgcaaagga atagtaaaga aagcatcttc aagatccaga acagaataat gggttgtgga 18601 gggaggtatt gaggatagga gagtatatgg gtttggcacc acagagtgga taggcaagac 18661 aatttggttg ataagctgaa gatcctggac aggctttagt cccttcaaag cctgttgtgg 18721 gatgggatac tggcattgag caggataagg gtaattaggt tttaatggga tggtagggtt 18781 gcgtgatcgg tcaccaagga gggagtagag gtatcccata cttgtgggtt aagataggga 18841 gtcaggaggg gaggttgtga aggaggcttt gaactgggga aaagggtggc aatgaggtgt 18901 ggctgtagcc caggaatagt cagggaagca gataatttag ttaaaatgtc tcaatttaat 18961 aagggagctg ggcaggtggg aataactaaa aaggagtgca taaaagaatg ttgtccaagt 19021 tggcaccaga gttggggagt tttaagaggt ttagcagcct gaccatcaat aaccacaaca 19081 gttatggagg caagggaaac aggcccttga aaggaaagta atatggagtg ggtagcctcc 19141 atattgatta agaaagggac agacttaccc tccactgtaa gagttaccca aagtgtctgt 19201 gatgatccag gaggcttctg aggtgatcag gcagtgtcag tcttcagctg ctaagctgag 19261 aagatctggg aaggagtcag tcagagagcc ctgggccaga gttccagggg ctctgggagt 19321 ggctgacggg caagttggac agtccgattt ccaatgcggt cccacacaga tgggatacag 19381 tttaggagga atcctgggct gtaggcattc cttggcccag tggccagatt tctagcactt 19441 gaagcaagat cctggaggaa tgcctgacca cagtggttta ggtgttttga agttcttgtg 19501 tgctggagat gtggctgagg tttttctcac agcagaggca agtaattgca actcagaaat 19561 acattgccac ttggctgtct cttctctatt attgtacacc ttgaaggtga ggttaattaa 19621 gtcctgttgt ggggtttgag ggccataatc taatttttga agctttttta atgttgggag 19681 tggattgggt aataaaatgc atattgagag taagacagcc ttctggcccc tctgaaccta 19741 gggcagtaaa atgtctaaga gttgttgcca aagggaccat ggactgggct gcgttttcat 19801 atttgatgaa aaaaaaagag cctaaatgct aactaatttg ggagaggtca gataaagtaa 19861 aaggaacatt aatcttgact atgccttcag ctcttgccac ctctctaaga ggaaattgtt 19921 gggcaagtgg aggagtgcta gtcgtggaat gaaaccataa gctggactgg gtgtgaggag 19981 gggaggtgat agaaggatta cagcgtaggg gagtagaggc tgaggaagaa ttgggacctg 20041 gctcagcctg gtgaggagtg gcctggtgag gagcagcctg gggaggagga gagaggttag 20101 atgggttcgt agaaaagaag gattcaaagg actcggagct tggtgaggag actgaaggaa 20161 cagacaggag agaaagaaga aagatttggg acaagtcgca ttgggagcag agactaggaa 20221 gggagtgatg tgtaaagaat gcctggacat caggcacctc agaccatttg cccattttat 20281 gacaaaaatt atctaagtct tgtagggtgg agaaatcaaa agtgccattt tctggccatt 20341 tggaacaatt atcgagtttg tattggggcc aaatggtgtt gcagaagaaa ataagatgct 20401 taggttttag gtcaggtgag agttgaagag gttttaggtt ttttagaaca caggctaagg 20461 cagaagaagg aggaatggag ggtggaaggc tgcccataat aaaaaggtaa gtttagagaa 20521 aagagaggat agagacacag agagaggggg tggtggtact catcagccag gggaggtggt 20581 acttgccacc aaggtgatgg atcaaggcag tcatccccac ggtgatcaga cacctctgaa 20641 atgtgggtga ataatcaggc aggtgtccct gcagtgatta gacaccaagg ggagactgtc 20701 ttcccgagtc cgtgaccggt gctggagttt tgagttcaca gataaaacac atctcctctg 20761 tctctaccag aaagggaaag gaactgaaat taaggaaggg agagattgaa gggtggagag 20821 atagcaagag agttggaaaa gagaataaaa agaggccact tactcaattt aaaattggtg 20881 agatgttcct tgggctgatc tgaggaccca aggttgtagg tggatctcct cacggaatga 20941 gggtgaggac aggggactgg tctccagaag gagttcccga gtcctggatc ttcagcacca 21001 aatgtcatgt gcatccatgt gaagagagtc caccaacagg ctttgtgtta tcaataaagc 21061 tttttaatca ccttggtgca ggtgggctga gtctgaaaaa ggagtcagca aagagagata 21121 ggggtgggtc agttttataa gatttgggta ggtagtggaa agttacagtt agaggtggtt 21181 atctcttgag ggcagaggtg ggggtcacaa ggtgctgggt ggggaaatcc tgagacttat 21241 catccaggga aggagtgtca caaggtcgat tgatcagttg gggtggggca ggaacaaatc 21301 gcatggtgga atgtcatcag ttaaggcagg aactcactat ttcacttctt ttgtggttct 21361 tcagtttctt caggccatct ggatgtacac gtgaaggtta cggggatata tgatggctta 21421 gcttgggctc agaggcctga cactaacctc ctgcagaagc cacaaaaggt tattacacat 21481 aaaccatggt ttccacaggc aggcactctt gatgtggaaa attgggatag agcaggatta 21541 aaacaagctc atcaaaaagg tcttaaagtt gattcttcag ttttctccac ttggagttta 21601 gttcatactg tacttctgcc attatctcct tattattctg cggaacagca ggctgaatct 21661 aaaaattgga aagaatttgt tgtcctactc acagctccaa ttgaatataa aaaacaggag 21721 agggaggata aaaattggcc tataccgcct cctccagatg cagaaacatc tgtaccatct 21781 ccttcagtgg cagaaataga gatcccagta caaagaattt tatgctctgc tgtcatagct EPI-109 856

21841 ggagagccct taggaccttg tgcttttcct atttctgtaa ggcctgatcc aaataatcca 21901 cagcagttta ttcatgaaca ctctccacta gaatttaagt tgttgaagga attaaaaact 21961 agtgtggtca ataatggagt acaaagccaa tggttcctgg aggaaggaat gctagacata 22021 gaactttggg agcaagtggg gagaaatctt aaacaacacc aggcacaaag gcatcaggtc 22081 ccagtaaaat cttttatgtt aggggctttg agtagagcag ccctggttgt tacacacaaa 22141 agagcctaaa aagggaaagg aggaggaaat gtcacctgcc ttatcacctc cccttccctc 22201 agtgccaata tcactgggcc aaaataacaa agaggaaatg gaggtcttac ctaagcttcc 22261 tcctccaata gataggaaga aggacagagg atacgctaca gctatcagtc cctgtcttaa 22321 gcaggcagca ttagaaggag agctcttagc cgggtgcagt ggctcatgcc tataatccca 22381 gcactttggg aggccgaggc aggcagatca tgaggtcagg agatccagac catcctagct 22441 aacatggtga aaccccgtct ccactaaaaa tacaaaaaat tagccaggca tgttggtggg 22501 cacctgtagc cccagctact tgggaggctg aggcaggaga atggcatgaa cccaggaggt 22561 ggagcttgga gctttcagtg acctgagatt gcaccactgc actacagcct gggcaacaga 22621 gcaagactcc atctaaaaaa agaagaagaa ggagagctct taacctgctc agtaatgcaa 22681 aatcggcaag gcaatcaggt gtatgtttat aaaaagataa gaaaaaggca ttagaagcca 22741 aaaccacgtg gccaagcagg cagtgggcag gagaaaatgc tcagaggcag aaaagctcac 22801 agcgacaaag ccaacaaggt ctgcccagga cggcagcatc cctctggcaa aggagcaagg 22861 gagcagcaca gacacaggca aagcctaaac aagtacaatg tggccacctc ccaggacctg 22921 caccactgcc ctctggctct gtgggcagcc cattgcaaaa tttcatgtgt tacatctcag 22981 gctatgattc tctgctaaga tgtaagtaaa atgtaagaat ttgaaaagca tcttttctaa 23041 taatggccac tattgtcatc tctctcctat ccctgatgta gctttccaaa ttcaatttaa 23101 gtaaaacagt aacctttgaa gggaaagaga ttacagaggg cccatgaatt agttgaagag 23161 taattaaaag ctaggcatgt aaaaccacac attacgcttt aaagaagaaa tttaaaccta 23221 attaaatgat atttgttaaa ttagaaggta aaaatgttgt gccctgttgg gaacaggccc 23281 ccaaatctgg ccataaactg gccccaaaac aggccataaa caaaatctct gcagcaccat 23341 gacatgtttg tgatggccat gatgcccacc ttgaaggttg ttggtttact ggaatgaggg 23401 caaggaacac ctggcccacc cagggcagaa aattccttaa aggcattccc aaaccactaa 23461 tgatagcatg agcaatctgt gccttaagga catgttcctg ctgcagacag ctagccagag 23521 cccatccctt tgttttggcc catccctttg tttcccataa ggaatgcttt cagttaatct 23581 atgatctata gaaacgatgc ttatcactgg cttgctgtca ataaatatgg gagtaaaact 23641 ctgttcaggg ctttcagctc agaaagccat aagccccctg atttcccact tcccaccctt 23701 tatttctgtg tgtgtgtctt gaattcctct agcgcctctg ggttatggtc tccacaacca 23761 cgctggtctt ggcagtgccc ttctcagaaa gtgaaaaaga gttgtatgta agtgtagtga 23821 aaacataagc atgaatcact gtcttaaccc actgattaga tagtctttga tttgtacttg 23881 ctaaaagagt cctaaattga gttcctcagc tagtgagtca ctgttttcaa gactgtttgc 23941 cagattgaag tccataaact tggtcagccc gaaaactcaa ttacaagatc taagctattc 24001 tgcctgtggc tttaagcaca tggttaaagt atattattta agtctctcct tctagatatg 24061 ctttcagatt ttctttttaa acttcttgtt acttatttca gctttccata ttgataatta 24121 atgcagtcaa ttgctcagtt atgactgtga tatcatcagg attcctttaa gtaaaaggca 24181 attcaaagcg gtattgcact cccccatacc taatgcttta acactgttta ctgatgggtc 24241 tggtaaacat ggaaaagctg cagtctagta gagaccacat aattcaatca ctcgatctga 24301 gttcactagc actcagagag ctaaggttac tctgtttatt tattaaagaa tttttacaac 24361 cttaagctca ctctggactt tccagcctta tgtggcaaat gtagccatca atttatgggg 24421 tcaagactta cttacagcat gggatatgag gcttacaaat gagactttga taacccagga 24481 ttttaaatgt tgaagaacac gggatatcag agtgaaaaag gtttagggaa aattctgaca 24541 agggaaaatt ctaacctgat atcaataact ggaaagacag gttaaaccct gcaaggggat 24601 acattgacat tttttcttcc tcacttgctc ttttctgctg tctgaatatg ggcatgaggg 24661 caagagtcat tttagaccac caagtgacct tgaggataga agccttatac tagaggtggt 24721 gggaaagaaa aaacagaagg actcataaag aaaaaaataa taaacctcag tattaagatg 24781 gaaaaattcc cccaattggt ctataggttg aacttcatct ctattaaatt tcagctatgt 24841 ttttgcagaa tttgatatgc tgatcataaa atttatatga aaatgcaaga gacacagaat 24901 agtcaaaact ttgaaaagaa gaaagttgga ggacttacac ttgttgattt taaggctttt 24961 tacaaagcta taataatcaa gacaatgtgt tactgacata atgatagaca tattgatcaa 25021 tatagacaat ggatgaatgg agtagaattg acagtctaga aataaaacct tatatatatg 25081 gtcaatttat ttctttatgt attctgtcat ccagaataca taaagaacac cttcaactca 25141 ataacaacaa taccaacaag ggtgccaaga ccaatcaatg gaggaaataa tagtcttttc 25201 aagaaatttt gctgagacaa ctaagtattt atatgcaaaa taatgagttt gaatggctac 25261 catatacaaa aattaactca aatggactat attaggtcag tgcaacagta attgcagttt 25321 accaccatta cttgtttttt ttttttggtt tttttttttg agacagagtc ttgctctgtc 25381 acccagacca gagtgcagtg gcatgatctc agctcactgc aagctccact tcctgagttc 25441 acgccattct ccttcctcag cctcctgagt agctgggact acaggcatct gggtaatttt 25501 tttgtatttt tagtggagat ggagtttcac catgttagcc aggatggtct caatctcttg 25561 acctcgtgat ctgcccacct cagcctccca aagtgctggg attacaggca tgagccacca 25621 cgcctggcct accattactt ttaatggcaa aaatgcagtt acttttgcac caccctaata 25681 gaactaaatg taagagctaa aactacaaaa ctgttagaag aaagcatagg agcaaatctt 25741 aatgacatga gagttggcaa ttgtttttta gatatgacac caaaagcatc aaggacaaaa 25801 gaaaaaaatg gataaattgg acttcctcca aattaagaga acttttgtcc tgcaagcaat 25861 actattaaga aagtgaaaag acaagtcaca aaatgggaga acatttttgc acataatata 25921 tttaataata ggctgacatc cagaatacat aaatacctac aactcaatac caaaaagaca 25981 gcccaattta aaaatgggcc aaggatatga ataaacattt ctctaaagaa gatacaaaaa 26041 tggtcaatat gcacatgaaa agatgctcaa tatcaatatc tattaggaaa atacaaatta 26101 aaacacaaaa tataaaacac aagatatcaa tttacactca ccaggatggc tgttatcaaa 26161 aagacagata acaagtattg gcaaggattt ggggaaattg taaccttcat acattgctgg 26221 taggaatata aaatttgcag caggtttgga aaacagttta gcagtttctc aaaaagcctg 26281 ggcatggtgg ctcatgccta caatcccagt gctttaggga gctgaggtga gaggattgct EPI-109 857

26341 tgagcccagg agttggagac cagcctgagt aacacagtga gacctctttt ctaccaaaaa 26401 gaagagagtt aaacataggg taccatataa gccagcaatc catctcctag atatgtaccc 26461 aagaaagttg aaaacatata ctgacacaaa aacttacata tgaatcttca tattagcctt 26521 ataataatag ccaaaaagta gaaacaaccc aaatacccat caactaatta aaatatggtg 26581 tatctataca tattatttgg ccataaaagg aagtactgat acatgtcata acacaaatga 26641 accttggaag cactatgatc tctgtattag tcagctcttg tattgctata aagaactacc 26701 tgagactggg taacttataa agaaaaaggc ttaattgagt cacagttcca caggctgcac 26761 agggatcatg gcccaggaga cctcaggaaa cacagttatg atggaaggaa gagagtgaag 26821 gaggaggtgc tacatacttt taaaccacca gatcttgtga gaagtcactc actatcatga 26881 gaacagcaag ggagaagtcc acccccatga tccagtcagc cccagccagg ccccaactcc 26941 aatattgggg attacaattc cacatgagat ttgggtgggg acactaatcc aaacaatatc 27001 attctgcccc agcccctccc aaatcctgtg tccttctcac attggaagat acaatcatcc 27061 cttctcaaca gtttcatttc agtattaact caaaaatcca aagtctcatc tgagacaaga 27121 caagtccctt ccacctatga gcctataaga tcaaaaagaa gttagttact tccaagatac 27181 aatggaggta caggcattgg gcaaatatat ccattccaaa agggaaaaat tagccaaaac 27241 aaaggggcca caggccccac gcaagtccaa aatcaagcag ggaaatcatt aaatcttaaa 27301 gcttcaaaat gatatccttt gactccatgt ctcacatcca ggccacacca atgcaaggag 27361 tgtgctccca aggccttggg cagctctacc ctgttgctct acagggtata gcccccatgg 27421 ctgctttcac aggctggcat tgagtgcctc cagcttttcc aggtacacag tgcaagctgt 27481 tagtggatct accattctag ggtctggaag attgtggccc tcttctcata gctccagtag 27541 acagtgcccc agtggggaat ctgtatgggg gctgcaaccc cacatttctc ctctgcactg 27601 cccaatagag gttctccatg agggctccat tcctgtagca tacttctacc tggacatcca 27661 ggtgttttca tacatcctct aaaatctagg taggggctcc caagccttaa ctcttgccct 27721 ctgcacatcc gcaggcttaa taccacatgg aaaccaccaa tgcttatggc ttgcacccta 27781 tgaagcagta gtctgagaca tatctgggcc cttttggcca tggctgggat gcagggaaca 27841 gtgtcctgaa gtggcacagg gcagcggggc catgggcctg gcccatgaaa ccttctttcc 27901 tcctaggcct ccagacctgt gatgggaggg tctgcctcga cggtctctag aatgtgtttg 27961 aggcatattc ctcattgtct tggctattaa tatttggctc ctctttactt atgcaaattt 28021 ctacagcctg attaattcct ttccaaaaaa atggggtttt cttttctact acatggtcag 28081 gtcacaaatt ttccaaactt ttacgcttcc ctttgaaatg taagttccag ttgcaggtca 28141 tttctttgat cacaaatata agcatatatt tgtagaatca gccaggccac atcttgaatg 28201 ttttgctgct tagaaactgc ttccaccaga taccctaaat cattgctatc aggttcaaaa 28261 ttctacatat ctctagggca agggcacaat gcctccaaga cctttgctaa tgcataagaa 28321 aattgacctt tgctccagtt cccaataagt tccccatctt catctgaggt ctccttagcc 28381 tggacttcat tgtccatatc agtatcagca ttttcatcac aataatttaa ctagtctcta 28441 agaagttcca aactttccct tatcttccta tcttcttctg agccctccaa actgctccaa 28501 cctctgccca ttacccgggt tccaaagctg cttccacatt ttcggtatct ttatagcaat 28561 gctccattcc tgataccaat tttctgtatt agtctcttct cgcactcctg taaagaacta 28621 cctgagactg ggtaatttat aaagaaaaga ggtttaattg actcacagtt ccacaagctg 28681 tataggaagc atggttcaga aggccacagg aaacttacaa tcatggagga aggcgaagag 28741 aaagaaggca cgtcttacgt ggctggagta ggaggaagag agtgaagggg gaggtgttac 28801 acacttttaa acaaccagat cttgtgagaa ctcactcact atcatgagaa cagcaaggga 28861 gaggtctgcc tccatgatcc aatcacctcc taccaggctc ctcctccaac attggggatt 28921 atgatttgac atgagatttg ggtagggaca caactccaaa ccatatcaat cccatttata 28981 tgaaatgtcc acaatagata aatctataga gacataaaat agattggtgc ttgcctagtg 29041 ctggacgtga caggagggtg tgagtaaaag aggcaatgga gtgataggta cagggtttct 29101 ttttggggtg atgaaaatat tataaaatta gattgtggtt atagttgtat aactcttgaa 29161 tatcctaaaa atatattgaa ttttccattt ccattttaaa tgggtgaatc ttatggtatg 29221 tgaattatat ctcaataaaa ctgcaaaaaa tgcacaattt gcaattgcaa aaatatggaa 29281 ccagtccaaa tgcccatcaa tgagtggata aaggaactgt ggtatatata tatatatata 29341 tatatatata tatatatata tatatatata tatatataca cacacacaca caccatggaa 29401 tactactcag ccataaaagg gaataaaaca atggcattct cagcaacctg gatggaattg 29461 gagaccatta ttctaagtga aataactcag taatggaaaa ccgaatatca tacattctca 29521 ctcataagtg ggagctaagc tatgaggatg caaaggcata agaatgatat aatggacttt 29581 gggaactcag ggaaagggtg agagaggggt gaggaataaa aggctaccca ttgggtacag 29641 tgtacactgt tcaagtgatg gctgcaccaa aatctcagaa atcaccacta aagaacttat 29701 ttacataacc aaataccacc tgtttctcaa aaacctattg aaattaatta atttttaaaa 29761 actgctgaaa tcaatagtga aaggatggac tattcaataa tgacacagtt aattgaatat 29821 catattttaa aaattagatc cttacctcac actataacat aacaataaat tccaggtgaa 29881 ttatagacca aatatgaaaa gcaaaatttt aatattttag aagacaattt ttatgacctt 29941 aagttagaaa atgattttta aaaacaggat gcaaaaacac taatcataaa gagatatttt 30001 aggccaagca tggtggctca cacctgtaat cctagtactt tgggaagctg aggcaggtgg 30061 atcacttgag gtcaggagtt caagacaagc ctggccaata gggtgaaaca tgtctctact 30121 aaaaatacaa aaattagctg gaaatcgctc gaacccagga ggcagaggtt gcagtgagct 30181 gagattgtgc cactgcactc cagcctgggt gacagagaga gactccacct caaaaaaata 30241 aataaataaa aataaagaga gattttaata aggtgcatta aaataaaaaa ctatccatca 30301 aagacaccat gaataaagtt aaaataggcc acaatgagaa tatatttgcc atgaattttt 30361 tctttttttt tgagatggag tcttgctctg tcacccaggc tggagtgcag tggtgcaatc 30421 tcggcttact gcaaacttca cctcccaggt tcaagcaatt ctcctgcctc agcctcctga 30481 gtagctggga ttacaggtgt gtgccaccat gcctggctaa tttttgtatt ttttgtagac 30541 acggggtttc accatgttgg tcaggctgag ctcaaacccc tgacctcgtg atccaccttc 30601 ctcagcctcc caaagtgctg ggattacagg catgagccac cgtgcctggc ctaccatgaa 30661 tattttttta aaggtagcat ccagaattaa taatcttctc caacaaattt cattagtagt 30721 cagggaactg caaattaaaa tcaaagtaaa atactacttt ccactcatta gactaaaatc 30781 cattcaagtc tgataatacc tagtactgag ttggagtaat agaaactgct aatgggacag EPI-109 858

30841 ttagttggtc atcactttgg agagaaatta gtcagtatct agtaaaagtt agtgatacac 30901 cttccatttt catctgttct gtgctgctac caaagaatac ctgagactag gtaatttata 30961 aataatagaa atgtatttct aatggttcta gaggctgaga agtccaagat tgaagggcca 31021 gcctctgcag agagccttct tgctgtgtca tgccatggca gaagggcaaa gagagggcaa 31081 gagagagcaa aagcaaattc acagcatcaa tcccttttat aatcagcatt actctattaa 31141 tgagggcaag accctcatgg cctaatcacc tctaaaaggt cacacctctt aatactattg 31201 caatggtaat taagtttcta atacatactt tttgggagac attttcaaac tatagcacct 31261 accctatagc ccaacatttc tactcctagg agtatgccct agagaaattc tgcataaata 31321 tctaaagaga ggccattgtt gcattgttag gtactggaaa attggaatca attactatgt 31381 ctaccagcag cagaagatgg ctttttaaaa gttttggttt attcatgaaa tggaatattg 31441 cataaagtat gctccatctc accagatgaa aacatttttc actaggacta tttcaaaagt 31501 agtcttatca ctgggcttct ctattatgca taaaaatttt aagtgaacat gttctttgac 31561 ctagtactcc tacttttagg aatttgccca aaagggacaa ttatactact gggataaatc 31621 tttgaatcat aaagtaagtt gtaaatggta caagcagtat gtcttatttt tatttaaagc 31681 acattaacaa tattacacat atagtaaaaa ataaataaat aaaacatgtg aataataaac 31741 acccaattta gaacaagtgt tgacagtgga gagggaaaga gagagaaaga aggagaaatg 31801 gggagtggga gcgggtacac aaggaaattt tagttgcagc tccaaatttt tactttttac 31861 acaatgaagc gaatatggca aaataagatt tgttaaagtt gggcagcagg tacacagata 31921 ttctatcatt atcctttgaa tatttctgta gatttaagtt gtccattaaa aaaataaaat 31981 acacacataa tttttaagat tagttttttc tatttcctgg ccttcgcatg cactgttaac 32041 tttacctgga attctttatg cagtaattaa gagcaaaggt gtagagcaag actgcttgag 32101 cttggatccc agcactgagt tgatttaggg agaataactt aatctcttaa tcccaagaga 32161 aaatatgata taatagtttt gagctcataa agttttcata agcattaaat gtgacctata 32221 tatgtaaagc aatctaacag tgcctatagt atttataagt gtctgcatta ccaaattcat 32281 cattatcatg gcatgtcatg tcaccatcca ctacattacc atcactgtca ccatcatcat 32341 catcaccacc accatcatca ttaactccct ttgtctagtc aattcatatt tgttcttcgt 32401 attttagata cctgttaaaa tattttttca aagatgtcta ctctgattct tcagtacaaa 32461 tttgatttaa taagatccta tcattttgtc caaatactta taaaaatttg tagttctata 32521 tttaatgtgt tttgtttgtt taacatctct ctcctacatt gtgttaagtt ttttaaagag 32581 aaggtaaggg ttaaagagag acatagagag agaaagagag acagagagag agagagagcg 32641 gttctacagc aatacaggta tattagaaaa acctgcaaag gtggggacca gcttaatgcc 32701 agagcccccc actgcttata ggctggggta cttataggtc tgggggtact tataggcctg 32761 ggtgggtggg gtctgagcag tatggcttgc tgcccaagaa gatgttgata agacgttccc 32821 atgatgaggc agtttggtcc ttgcttccat agagtgtgat gcttcttgca ctttttccca 32881 gcagaatgtg gtagggatgt tccttcaggt gggcctttgc ctggcagggt atgataagga 32941 tgttcctgtg ccttggaatc aggtagttag acaggatgtt tctcacagcc tgaaccccca 33001 tggaatgttt cactttgacc agggtctgcg aaatagcagg gggcttacaa aatggtgtag 33061 tttggactaa caccttggaa cacaaaagtt tcttggggcc aaggctggcg tattagtctg 33121 ttttcatgct gctagtaaag acatacctga gactgggtaa tttataaaga gaaaagaggt 33181 ttaatggact cacaattcca catggctgga ggcctcacaa tcatgaggga ggcaaaggag 33241 gagcaaaggc acgtcttaca tggtggtagg caagagaacg tgtgcagggg aactgccctt 33301 tataaaacca tcagatcttg tgatacttat tcactatcaa aagaacagca cgggaaaaat 33361 ctgcctccat gattcaatta cctcccacca gattcctccc atgacatgtg gtaattatgg 33421 gaactacaat tcaagatgaa atttgggtgg ggacacagtc aaaccatatc agctgggtat 33481 gttttattca cctttttata cccattgtca tgtcttctgg acaaacaatg gatgtaaaat 33541 ggtatagact cctgagtact catttgttga atgacaaatc tatgaaccat ttgaccagta 33601 tgcagcagcc attaaaatta tgtttatgaa taatttacag catggaaaaa tttggggttg 33661 ctagtagaaa aacaaaaagg tacaaaagga tatatataat aagcctacaa tgccatataa 33721 acaatactaa cagcaaaaac aaacctataa attgggggaa gatggggcag atagaagtaa 33781 cctaaaatac taacatgttg ttttggggtc atgaaattat aaatgattat gcacccctta 33841 atttttactt tctatgtttg atttttctat ggtaaatgca tttttattga ggtggaattc 33901 acataacatg aaatgaaaaa tttagtggca tttattatat tcacaatatt gtacaaccac 33961 tagctctact tccaaaacat tttcatcact ccaaaataaa accttgtacc cattaagcag 34021 ttactcccca ttatttcctc tcttagctcc tagcaaccac caacctgctt tctgtctcta 34081 gggatttatt tattctgga.t attccataaa aatggaggca caatatgtac cttttatgtc 34141 tggcttcttt caccaagcat gtttttgagg ctaatccaca ttgcagcatg tatcagtact 34201 tcatttcttt ttatgaataa ctgtatacag accacaattt gttatccatt ttttggttta 34261 tggacatttg ggttgtttcc atctctcaac tattgtgaat agtgctgcta tgtatatttg 34321 tgtacaagaa tttggttacc tattttcaat tcttttatgt atatatctaa gatgaaattg 34381 cagggttata tgctaatcct atgtttagca ttttttttta ggaaccatta aactgttttc 34441 caaatctgat gccccatttt atattcctac tagcaatgta agcaagttcc aatttctcca 34501 tatcctcaac aacacttgtt attttctatt tttgttatag ccattctaat gagtgtaaag 34561 tgatatatca ttgtggtttt ctttgcattt tccttatgaa cattgatgtt gagtaccttt 34621 tcatgtactt tttggtcatt tatatatcat ctttggagaa atgcctcttc gtgtatgttt 34681 tgcccatttt aaaactagat tgtctttgtt gttgacatgc atgcattctt taaatattct 34741 gcatactagg cccttatcag atatatgatt tgcaaatgtt ttttctcatt ttactggctg 34801 tcttttcact ttattgataa tgtcctttga tgcccaaaag ttgtttattt tgatgaagca 34861 tatttatcaa tttatttctt ttattgctca tgcttttgat gtcacctcta agaatttata 34921 accaaatcag aggtaatgaa ggtttacccc tctattttct tctaagagtt ttatagtttt 34981 gactcattta cttaggtcgc tgattcattt ttagttaatt tttgcatatg atgtgaggaa 35041 gaggtccaac tttactcatt tgcatgtgga tattcagctg tgccagcacc atttgtgaag 35101 agtctatcat ctcctcattt aataatagta ttgacacctt tgttgaaagt caattgataa 35161 taaatgtatg agtttatttc tggaatctaa attctattcc attgatctac atgtctatcc 35221 ttgtatcagt atcacactat cttgattact gtagatttgt agtaagtttt gaaactagaa 35281 agtgtgagta ctgcaatatt cttctttttc ttttttaaag attgtcaggg cctcttgcaa EPI-109 859

35341 tttaataggg atatgaggat tgacttttct attctacaaa attaaaattt tgttagagat 35401 tgcattgaca ctgtaggtag ctttcagtaa cattgccatc tcaacaattt taagtattct 35461 aatacatgaa tatgagcttt ctttctcttt atttaggtct tctttaattt ctttcagcag 35521 tgttttgtag ttttggggta caagtctttc acctttaaat tttggtgaaa tttattccta 35581 ggtattgcat ttttttatgc tattgtaaat aaaattattt tctcaatttc ctgttggatg 35641 ttcattgcag gtgtatagaa actcaactga ttctttgtgt tgatcttatg ctgagaccag 35701 ctcagttggg gagaccctaa cctagaagca ctagaggaat taaagacaca aacacagaaa 35761 tatagaggtg taaagtggga aatcaggcgt ctcacagcct tcagagctga gagcttcaaa 35821 cagagattta cccacatatt tattaacagc aagccagtca ttagcattgt ttctatagat 35881 attagattaa ctaaaagtat cccttatggg aaacgaaggg aagggctgaa ataaagggat 35g41 gggttgggct agttatctgc agcaggagca tgtccttaag tcatagatca ctcatgctat 36001 tgtttgtggt ttaagaatgc ctttaagcgg ttttctgccc tgtgtgggac aggtgttcct 36061 tgccctcatt ccggtaagcc cacaaccttc cagcgtgggc attatggcca tcatgaacat 36121 gtcacggtgc tgcagcggtt tttatggcca gttttggggc cagtttatgg ccagattttg 36181 gggggcctgt tcccaacaat cttatacctt gcaattttgc tgaatttgct tgttaacttt 36241 gatagttttt ttgaggatta tttgggattt tctacatatc atgtcatctg tgaataaaga 36301 tagttttgct tctttctttc tcatttggat gccttttatt tccttttctt gcctaatttc 36361 cctggctaga acttccagta tgatgttgaa taaccatggt gaaatgggca ttcttgtctt 36421 tttcctgatg ttagagagaa atttttcagt ctttaaccat tgagtataat gttagctgtg 36481 ggttttttac aaatatcttt tatcatgttg aggaagttcc ttcctactcc tacttcttgg 36541 agtgtttttg atataaaggg tatttaattt gtcaaatgct ttttctgtgt cagttgagat 36601 tatcatgtga gatttttttt ccttcattct attagtgttg atgttacatt ggttgatttt 36661 ttatgttgta ctacatttgc attctttata taaatttcac ttggtcatgg tgtataaccc 36721 ttttaatatg ccattggatt tagtttgcta gtattttgtt tagagttttt gcatctatat 36781 tcataagcaa tatcagtcca caggtttttt gtggtttatt tgtctggctt tgctataatg 36841 gtaatgctgt cttcttagaa tgaatgaggg agtgttttct cctctttcat tttttaaacg 36901 tttgagaagg agtgatatta atttttcttt aaatgtttgg tagaacttac cagtgaagcc 36961 gtctggttct taacattttt ctgtgttggg aggtttctga ttaccaattt gatctcttta 37021 atttttacag atcttttcag attttctatt tcttcttgag taacttttta gcaatttatg 37081 tattttagaa atttgttcat ttaatctagg ttatttaatt tattggtgtg cattttttca 37141 tagtattatc ttataatctt ttaatttttg taaagttgat aatgtcccca ccttacctga 37201 tcttagttat ttgtgtcttc tctgtattct ttttgtcttc ttcttctgtc ttagcatagc 37261 taaaggtttg tcaactttgt tgatctttta aagagtcaac ttttgctttc agcatgcatt 37321 actttttaaa tagaaatata tacacctaag ttgcattaca aaggagttgt cctccacaca 37381 cttattcttt cccaccatca gaggtttatg gtccccgcaa aagtcaccat cagttgggct 37441 caactccaat cagtcatggt aggtcagggt ccatctcatt gtctccatca ctcatgccca 37501 cccagggtaa gtctaatcat gttcaccaat cagaacctct gccacatcag ctctgtgggt 37561 ttcctctcat gccatctgta ccaacaatga gcacagtctg ggtttcctga tgttttctat 37621 agcatggtgc ccctccctgg gacacctcag aagccacaat gatattcatt aaacttcttc 37681 ctgcaagtac tccctctatt gctccttcta ctcaccaagc ttagtgtcag ggaatatgct 37741 ggtggggagt atgaatctta gcttctcact cccagactcg gctcccaacc tgctgttgcc 37801 aagtcttggg gacatctata aatgccttct aaatacctgt cttggcctat ccccagccac 37861 agattcctcc ctagagcagg ctacctctga ggcatctata ctgagatctt aatcacagag 37921 acatttaaaa catctaggct acaaaagaat tcctactata gggttcaaat gaatttcttt 37981 ccgtcacttg agacagcttt ttagcaagta catgtattaa agattctgat ttcccctttt 38041 ttctcctaca gtttgtttgg cctaaaggta tgacatctaa tctgctgcat ttacactcta 38101 agtcaaaatt accattttgt tcttttaatt tctatttcta atcatacatt cttgtctact 38161 cctggttcat ctggagacaa agttgaactt agaagatgga ggagaaattc ttatctgccc 38221 tctgctagtt gacacttcct ttccaagaat catttgcagt tgctgggctt tcttgctgtg 38281 actctatgcc ctgttgtgtt actttttcat ttgtgacaaa aacagtggta atagtttgct 38341 tcatttttat tatgaagact tgaccaggat aggtaggaac ataattactg ctttttctgt 38401 gggcatcata ttggtccaga tcatgtttaa ccagaattga agatgtaaaa tcctagaact 38461 cactaatcta ttttagtagg tcacaggaag catgcaaacc ataaaaaccg caatgaacca 38521 aaagcatctg tgttgacaag aggcaagaat ttctctattt tctaaaggca ctaactgaac 38581 aaatctattg cccattactt aggaaattgc taagggcatc gttaaagtac ttcaggctgt 38641 tgaaaaacct tttctgtctt cttgccccac caccaattct ctctagctat gctttctctc 38701 acatgttctt gccatccatg gagtggcaga gaggttctga gtacaactct aactttcagt 38761 ttcaatggcc taatccccaa ctcaactgct gaccttgagt gtaaaaataa acaagatctt 38821 aaacatctta gggccagcat tctgggtctt cttttgttat ttggggagca taaactattc 38881 tcatatcatt ggcttgcaga aaaattgagc ttctcctctt ccttgcccca tgtcaccttg 38941 aggtgaccac agccctgcct tctatgtaat cctgcttggt cagcaggcac atcagagctc 39001 agtggcttgt gacatacttt ccttcaagcc tgctcgaagg gccatactca tcattgagac 39061 tgggaacctt agaaaccatg aacccagtgc caatgggtag atacagaatt ctcaaactca 39121 tgaaaaaaca tcctttttaa ctctctccgt gtgcataaag aattctaaga tgtactgatc 39181 aagattccca attttctaac tatctattaa tatatggacg aggtaagaag aaagttgcaa 39241 gaaaaaaatt tgtttgactt gacggttgtg tggttatttg ccacactccc ccagatccac 39301 tctgagtccc aggatgctga ttttaggggc tacattgcct agactgtcca ttattccctc 39361 ttcccatctg gttcagtcac tgggaagcac tggtaggagg tcagagtggg agaaggaggt 39421 taggatactt tctgcccctg ctgtcctact gctttgctga acttctagca gtggctgagc 39481 catcaacctg cagctctcaa ttccagctgt ctgtagcact caagtggtat tgtttattct 39541 tttgatcctt ctagctgtta aggaagaaaa aaataatttt ttcctcaatg ctcataagtt 39601 cttggaatgg acccctgtaa caaaagacag attaacacga gaaaagttta ttaacgtaca 39661 tattttatac gtacatagga gctatccagg gaatgaataa ttcttaaaaa ggtgactttg 39721 aattccagct catatagcat cttcaacaaa gttcagtaac attttagaga tatgacaaga 39781 caaagaaaat gaactttgag cctctaggga cagtgacttg taggaaggca aaaggaataa EPI-109 860

39841 atggaggtaa aggctggtta gtaatacttg ttaatgaaga ttcctctggt gccatctcca 39901 ggtccacaag gatttaaatt tgtcttcagt ggtgaacctt tgttcaccct ggcagaaggt 39961 gtggaggggg gtgcagatcc gttttgtctt tgtaagtcta tatcctgctt ttagacaaat 40021 aaagggaggg aaaagagctt tccttcatct gcttcttaat tgccttcagc tcaacaatcc 40081 ttatgcaaaa gaggtacatt ttagggtgtc aaattctggt ctcccacaaa gcatagggat 40141 gacagaccac ctcaccatcc ctgttgcttc ttttaagcct gctcacccct ccaaaaatat 40201 tttcattcta tactgtctct tcaaaatctc agcggagggt gccctctgtt atcctgccct 40261 ctgtgtcagt ataagccaaa ggtttgaatc ctggctctgc aactatctac ctctgtgcct 40321 ctccttgttt atgaaattac agggctggag acaaagatca caatgtgaag acaaaattgg 40381 agagcggtcc taatcagcca gagcaaaatt tctggctctt gctcttcccc atcctgggtt 40441 gaatcatagg aacaggtggc aagatgccag ggtcaggaga ttccagaagt ggcagcaagc 40501 tcagtgttac caggtcaggg atgacctgtc ttattattga aatctcagag atatgctcca 40561 attccggccc agagacacat tgagagacaa ctggggaact tgctatgttc ctgaacaggc 40621 aatgagctgt cttccaagaa aaaacctgag acccttcaag tctcaggtct tacttagcac 40681 atataccagg tcttacacag gacacatggt tacaactgac tgaaatctgg gctgggtgta 40741 ggagctcaca cctgtaatcc cagcccttca ggaggctgag gcaggcagat tgcctgagcc 40801 caggagttcg agaccagccc gggcaacatg acaaaacccc atctctacaa aaaatagtca 40861 ggcatggtgg catgcacctg tagtctcagc tacttgggag gctgagatga gaggattgct 40921 tgaggttgag actgcagtga agcatgatca tgccaccgca ctccagccta ggcaacagag 40981 caagatcttg tcgcaaaaga aagcaaaaac acaacataac acaacaacaa caacaacaac 41041 aacaacagca aaaaagccaa cttcttgaaa tctggaaagg acacctggac tgccctgagc 41101 atttgattgt tgttggctct agcagtggat gcatccttca acctctggca ctctgcaggg 41161 ctcagactgt tctgttctgt ttgttacctg tggagtgcct gccagaccct gctctagctg 41221 ctttaggtcc atttaccctc atagaccccc agtcttgtta ttcatatttc atatttggga 41281 aatggaaact tagaaacttg ccaagtccac agcatgagat cctgcctccg gtgtctgctg 41341 gattccagaa agtgccaggg gccaacttag atgacaccat gttctctgca caatcttagg 41401 aatgctccta gtctgatgtc cccattgcaa aatttacatt atcttttaac aaaacgtctt 41461 tccaaggagg ggcatttaaa ataactgagg ttcttcttgc taaggacgtt cctgacacaa 41521 gagataattt agcatttcct tttcattaaa aagtttgaaa tcctgtaatt tgtgataatg 41581 tggatgaacc tagaggatgt taagtgaaat aagccacaca cagatagaca aataccacgt 41641 gatctcactc ttatgtggaa ttttttttta aataagttgc ttagccgggc atgatggcac 41701 acacctgtaa tcctagctac tcaggaggct gaggtgggag gatggcttga actcagaagg 41761 tggaggtagc agtgagctga gactgtgcca gtgcactccg gtctgggtga cagaatgaaa 41821 cccaatttaa aaaaaaaaaa aaagttgcta tcttagaaaa agacagtaga gcagtggtta 41881 ccagagactg gggaggaaag agaggaggtg agaatgggca gcagttgatc aacgggtaca 41941 aagttaccat gagataggag aaacaagtgc tggtgctctg ctccaagtag ggtgacggta 42001 gttaataatg aattctgtat atataaatag ctagaagaga gggttttcaa tatcattatt 42061 atttcaaaag aaatgataaa tgtttcagag gatggatatg taattaccct gatttgatca 42121 ttgcacaatg tatacatgta gcaaaacatc acattgtgtc ccataaatat atacaattat 42181 tatgtgaatt aaataaaaaa aaattttaaa gtcttatcta aatgaaattt ctaaccagat 42241 tctgaatcca tgataccact gaaaccagca cacatgatcg cagtaaaacc tcattatact 42301 tcctccacta tcaccaatac cctttattct ctggaacatg aaacattctg ttgtgctcat 42361 atcatgcaaa ttatcactag taggagagca gagagtggaa atgttccagg tataaagacc 42421 cacaagataa agaagctcag agtcgttaga aacaggagca gatgtacagg gtttgcctga 42481 ctcacactca aggttgcata agcaagattt caaaattaat cctattctgg agacctcaac 42541 ccaatgtaca atgttcctga ctggaaaaga agaactatat ttttctgatt ttttttttca 42601 aatctttacc attagttgcc ctgtatctcc gccttcactt tctgcaggaa actttatttc 42661 ctacttctgc atgccaagtt tctacctcta gatctgtttg gttcagttgc tgagaagcct 42721 gacataccag gactgcctga gacaagccac aagctggtga gttgtaggca ttttttccat 42781 tactttctga ttcataggct caacgcacct caaagctgga aatgccgggt ctgggtacac 42841 cctggggaac tgcaaagcct gcacacttgg gggaaatgat caagatgaga ggcaggggtg 42901 gggatggcat gtgcaccagg agatgttaga gaaaccctga ggaagagcag cgtgcagcag 42961 gtgatggggg agagtgggca gcaagcgagg ccaggacagc cactctgctc agtcaccagt 43021 ccacacaccc aggggctcac tctgcccctc tgagcaccca aggacgttaa agagctggaa 43081 ctgttagtct aaatatagga ccatccaagc tctgaaccaa aatgtgtccc ttgcctcaac 43141 tcaggagatc cacagaggca gaagtaagga atttattttc tgaaagatag atttctatca 43201 gttctgggtg acatgttctg acacttgaaa tgacacctag gacagcacat ttcaggcatc 43261 ttgctcattg ttcactgtag tagaagctac atgctagcca gttgtaaaaa tgaaattaag 43321 taatgtgtgc acagcattta acatagcatc tgagcttcag gagcactcaa ttaatgacca 43381 cagttgtgat tctttaggca gatgcatttt tttccaactt tgatcagagg tcttatttag 43441 cttctccaga tttcaagaat ctggctcagt gatatgaaat acaagacttg tgaaaagtgt 43501 caattgcaag agaaatggaa ggataaagta tacaggtggg tggaaaagaa attcacagtc 43561 actgccagaa aaaaaattct tgagaatcaa gtcctgatga tgttagggct tatagttctt 43621 attataaaga gttttatgta ctcattcagt gaacatttat tggtgcctcc tttagccagg 43681 tactatcata agagctgaaa ataaaagcat aatccagtcc ttgatcttga ggaacatgct 43741 gtgtgtagca gataacataa taagtgctta tctagatgca tgcagtgtta tgtgataaga 43801 gtaatatgac agaggataca gattaggctt cacagagaag ggggatttga gcaggaggta 43861 ttgaagggtg aatagaagct caccaatcat tttgggcaga ggggcaagga cctgcaaaac 43921 cactgaagca tgaaggaaat ggtgagttta gggaaaatga agagaagatg gctgtgactg 43981 aagcacagga tttgggattg gagaagggac tggaggtgag gctgagaaga ggcaaactca 44041 gaaaagatgt tgtgctgggc agtctggaca ttatctttga agcccaccac atataagtca 44101 tagggctact ggaggtttta agctaaaagt gactattcaa tttcaactta agagaagata 44161 ggttgagagg gaacatggct tgagatgagc catgagcaaa ggaaagacta caacaaagcc 44221 aggagtgagg agtgtgtgaa gcaagaaagt gacagttgaa agcagtgcag aggggatgaa 44281 tctgagaggc atctatgag.g tggaactcaa atgacatgat aataatacag ggcatttctc EPI-109 861

44341 tgtgtcagat gctgtcctaa gtccttactc cattgatctt cacagcaact cagcatagtt 44401 aatattttat gcataaagaa atcggcactt gaaggagtaa ttggccccag attacactgc 44461 ctataaggat tcaaatccag gtttgtttgg ctccaaaaac tggctcctaa ttttcagaag 44521 gagaagcgac ccagggcaat gcccaatttt gcttcttagg caatggagga atccacaatc 44581 ggaaggagtt ttcagcagtg ccccatttgg ggtgggttga atttgaggtc cctgcatgat 44641 acccactttg ctcacttcag tgcctaaaac tgagtatggt tcatagtagg tgttcaataa 44701 gtgttgatgc agtgaataca tgcatgggga gatatgcatc aggcaatggg aaattcaact 44761 ctaaggctta ggggaaagct ggagcttgaa gacagagctt tagaaaacag tagcatagaa 44821 gggagtagga accatgagtt tagacaatac aattcaggaa gaactttgta gcaaggataa 44881 agaggcaaaa aattaaagag gtgagagcta agtgtggtgc ctggggaatc ttaaggtgtg 44g41 ggcacgggga ggagatgcca gcaaagaaca tgaataaaaa gcggtagcac agcccctccc 45001 atctggaagc caaaaagaat tgtaaatgga ggaagttagc agaaggatca aatacttgaa 45061 gagggtggaa ttggaataaa accagggcat ttgaaaaatt gggttgtcac tgcaatctta 45121 acaagagaag ttttggcagg atgatggagg cagaaagctg agagaatcat cagttagaac 45181 gtttttgact tcagagaaca gaaaatgcag ttcataatgg ctttaaaaca ggggcttgtt 45241 tttctcccag caatttgaga ggccaaggcg ggtgcatcag gaggtcaaga gaccgagacc 45301 atcctggcca acatggtgaa tccccatctc tactaaaaat acaaaaatta gcggggcatg 45361 gtggtgcacg cctatagtcc catctactca ggaggctgag gcaggagaat cacttgaacc 45421 caggaggtgg aggttgcagt gagctgagat catggccact gcactatagc ctggagacac 45481 agcgagactc cgtctccaaa aaaaaaaaaa aagaaggcag aaggtgaata gttcaagggt 45541 gggtttagga ctcagtgata ataggattct gcctggcttc tcatggttct ctaggtcttc 45601 cattcatggc accatgccct cactaggcat gctgccagag caggaggggc aggtggaggg 45661 ttctcttgtg tctgtcttat cagggaagaa gagctttctc agaagccccc agcagactcc 45721 cttttcatat tatggtccag caatgagtca cagacctatg caccacctgc aaaggagcca 45781 gagaaaacaa acgcccagcg cttttagcct gaaaatgaga atctggtttg ctggggaaga 45841 taaagggtgt cggaaaatgg ctgttgggta aatcattgat gtctgccact aggaatgaaa 45901 ggcaaatcag gaactggcac acatgctttc agggagatgg ctgcaaggga gagggcaaag 45961 actgggaagt tgcttatgtg gtgccagact atttggaaga tcatggattg cggtgtttgt 46021 gttgtgtggt catcattttg ttctttgttt acagaacaga gaaagtggat tgaacaagga 46081 cgcatttccc cagtacatcc acaacatgct gtccacatct cgttctcggt ttatcagaaa 46141 taccaacgag agcggtgaag aagtcaccac cttttttgat tatgattacg gtgctccctg 46201 tcataaattt gacgtgaagc aaattggggc ccaactcctg cctccgctct actcgctggt 46261 gttcatcttt ggttttgtgg gcaacatgct ggtcgtcctc atcttaataa actgcaaaaa 46321 gctgaagtgc ttgactgaca tttacctgct caacctggcc atctctgatc tgctttttct 46381 tattactctc ccattgtggg ctcactctgc tgcaaatgag tgggtctttg ggaatgcaat 46441 gtgcaaatta ttcacagggc tgtatcacat cggttatttt ggcggaatct tcttcatcat 46501 cctcctgaca atcgatagat acctggctat tgtccatgct gtgtttgctt taaaagccag 46561 gacggtcacc tttggggtgg tgacaagtgt gatcacctgg ttggtggctg tgtttgcttc 46621 tgtcccagga atcatcttta ctaaatgcca gaaagaagat tctgtttatg tctgtggccc 46681 ttattttcca cgaggatgga ataatttcca cacaataatg aggaacattt tggggctggt 46741 cctgccgctg ctcatcatgg tcatctgcta ctcgggaatc ctgaaaaccc tgcttcggtg 46801 tcgaaacgag aagaagaggc atagggcagt gagagtcatc ttcaccatca tgattgttta 46861 ctttctcttc tggactccct ataacattgt cattctcctg aacaccttcc aggaattctt 46921 cggcctgagt aactgtgaaa gcaccagtca actggaccaa gccacgcagg tgacagagac 46981 tcttgggatg actcactgct gcatcaatcc catcatctat gccttcgttg gggagaagtt 47041 cagaaggtat ctctcggtgt tcttccgaaa gcacatcacc aagcgcttct gcaaacaatg 47101 tccagttttc tacagggaga cagtggatgg agtgacttca acaaacacgc cttccactgg 47161 ggagcaggaa gtctcggctg gtttataaaa cgaggagcag tttgattgtt gtttataaag 47221 ggagataaca atctgtatat aacaacaaac ttcaagggtt tgttgaacaa tagaaacctg 47281 taaagcaggt gcccaggaac ctcagggctg tgtgtactaa tacagactat gtcacccaat 47341 gcatatccaa catgtgctca gggaataatc cagaaaaact gtgggtagag actttgactc 47401 tccagaaagc tcatctcagc tcctgaaaaa tgcctcatta ccttgtgcta atcctctttt 47461 tctagtcttc ataatttctt cactcaatct ctgattctgt caatgtcttg aaatcaaggg 47521 ccagctggag gtgaagaaga gaatgtgaca ggcacagatg aatgggagtg agggatagtg 47581 gggtcagggc tgagaggaga aggagggaga catgagcatg gctgagcctg gacaaagaca 47641 aaggtgagca aagggctcac gcattcagcc aggagatgat actggtcctt agccccatct 47701 gccacgtgta tttaaccttg aagggttcac caggtcaggg agagtttggg aactgcaata 47761 acctgggagt tttggtggag tccgatgatt ctcttttgca taagtgcatg acatattttt 47821 gctttattac agtttatcta tggcacccat gcaccttaca tttgaaatct atgaaatatc 47881 atgctccatt gttcagatgc ttcttaggcc acatccccct gtctaaaaat tcagaaaatt 47941 tttgtttata aaagatgcat tatctatgat atgctaatat atgtatatgc aatatatata 48001 ggctcttgct tgatctctcc aggaggtagt gattatgaga agggggtgga gaatgatgag 48061 ttccttcacc aggagcaaag gacggggatc gtgtggaacc actgcagaac tatttccgga 48121 atcaactaag tggagagagc caggaaggct gcatcagaac ccagtaaagc ttcttgtctg 48181 gatctgagct ggtttgtttt gtgcttgctt ttccctgcct tgccactccc ctcactcttc 48241 tcttttcccc acagcctttt tcacatagct cttggctgta ggattgcccc actccaaaaa 48301 ccagtgtgtg gaggtccagg agtgagacca ggaaagaatg tgaaagtgac tacacaagga 48361 ctcctcgatg gtcgtggaaa aggaaagtca attggcagag cccctgaagc cagtcttcag 48421 gacaaagaag gagcctagag acagaaatga cagatctctg ctttggaaat cacacgtctg 48481 gcttcacaga tgtgtgattc acagtgtgaa tcttggtgtc tacgttacca ggcaggaagg 48541 ctgagaggag agagactcca gctgggttgg aaaacagtat tttccaaact accttccagt 48601 tcctcatttt tgaatacagg catagagttc agactttttt taaatagtaa aaataaaatt 48661 aaagctgaaa actgcaactt gtaaatgtgg taaagagtta gtttgagtta ctatcatgtc 48721 aaacgtgaaa atgctgtatt agtcacagag ataattctag ctttgagctt aagaattttg 48781 agcaggtggt atgtttggga gactgctgag tcaacccaat agttgttgat tggcaggagt EPI-109 862

48841 tggaagtgtg tgatctgtgg gcacattagc ctatgtgcat gcagcatcta agtaatgatg 48gθl tcgtttgaat cacagtatac gctccatcgc tgtcatctca gctggatctc cattctctca 48g61 ggcttgctgc caaaagcctt ttgtgttttg ttttgtatca ttatgaagtc atgcgtttaa 49021 tcacattcga gtgtttcagt gcttcgcaga tgtccttgat gctcatattg ttccctattt 49081 tgccagtggg aactcctaaa tcaaattggc ttctaatcaa agcttttaaa ccctattggt 49141 aaagaatgga aggtggagaa gctccctgaa gtaagcaaag actttcctct tagtcgagcc 49201 aagttaagaa tgttcttatg ttgcccagtg tgtttctgat ctgatgcaag caagaaacac 49261 tgggcttcta gaaccaggca acttgggaac tagactccca agctggacta tggctctact 49321 ttcaggccac atggctaaag aaggtttcag aaagaagtgg ggacagagca gaactttcac 49381 cttcatatat ttgtatgatc ctaatgaatg cataaaatgt taagttgatg gtgatgaaat 49441 gtaaatactg tttttaacaa ctatgatttg gaaaataaat caatgctata actatgttga 49501 taaaagattt aaaaacaact ggctgttttt ttacactgtg gtgtggaaga ttgtgttgtg 49561 ttcacaactt ttcacttctt cccctgtgtg attacacaca cctgcccttg tggtgtgact 49621 tgcagtgcgc cctacaggcc acacaacccc atgccctcca ccactggctc tgctgctgga 49681 atgtgagcag aagtgacatc tgcctcatcc aagcagagcc tcttgctcag ccacaggaag 49741 gcccattcca gatcacaccc gtcagcccgt gcgccctggt gaatgagaag acacagggag 49801 ctgcagccac atataacatg agcaagaagt ctgtgtttgc tgtgataagc cactgagttt 49861 taggggttgt ttgttaagaa gcacaaaaac cgattaagac atgtggtata tagtgacttc 49g21 atatatagaa tctggaaaac tatccattta ttttcaatca tggaattcaa tatgacaagc 4g981 atcccggagg gtctacctat gccagactgg gttggaaaca gaaagacaga tgttaatgcc 50041 agtgtccttt acacctccaa gtccagggcc agctgtggag tgggaggggt agagaaggtc 50101 ctgtgcacag tcacagtgcg ctgtgcagag caggaacaga ggcatctgtg aaaagtgctg 50161 agagcctgga ggacagagtg actaatgcaa tgacagtctt gcatcatagg aataacagcc 50221 acagcaggat tttattgctg ccaaagaaac tgccatttaa aaattgccag ccatccggga 50281 ggctgaggca ggagaatggc atgaatccag gaggcggagc ttgcagtgag ccgagatcgg 50341 gccactgcac tccagcctgg gcaacagagc cagactccat ctcaaaaaaa aaaaaaaatg 50401 ccagccatct ctctttctaa agtggaatcc tcaagtctcg tttattctgg ggacatttga 50461 gtaggctgtt cgagttaagc aggtggaagt tgatgatccc tcatcatcat tctgagggat 50521 gagtgtctga agactttttg gtaaggaagg gtcttggcat agcccacccc atgccacctc 50581 ccttgatctg tgatatcccc agcagctggg gaggttggag cattttgcaa agaggccccg 50641 aagcctccag aaagtaaacc ttcaagagcc catccttcct tcctcttttg tttttgctca 50701 ttatgaaaac ttccctgaca aattgaaaag gcttcaggtg agattagccc acaggaaaaa 50761 ccaccaaggg ccacccagag gggccacact gtgacagaag gagtatgggc tggtgagctg 50821 acctctggaa gacagtgcat gaattgagga gaagagattg gttccaggca tgggaggaat 50881 gaggctggaa atttcttcag acattgccac ttcggcactc tgtgtgtgtg tgtgtgtgtg 50941 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtaaacaga gtcctgtaat gcaaggtccg 51001 gccttggcag ccccagcctg gagccacagt gagatgtgag ctgagggtta tgctgggaaa 51061 aacctctccc tcccagcacc tgaaaggctc tgcaggccca gcagctcagc aagcaagggt 51121 aagggcatgg actaacatct tatttcatac tatcccttat aacacatcct aatgtaatca 51181 gctcacaata tgaaattatt tcatttctct ccagtcattg tttcaatggg gccttagggt 51241 tgactggatt ctggaggtcc ctgcctagag gagggggtgc attctgtccc tatgtcccct 51301 cctgctccat cctccacagc acgtgcctag tggtctacct tgtggggaat tcttgtacct 51361 ccctcttcta ggcatggact agcattgaga agtgggagag gagtgttagg aaaaagggca 51421 aatatagaca taccttgtct tattgtgctt tacagatatt gtttttgttg ttgttgttgt 51481 tgtttacaaa ttgaaggttt gtggcaaccc tgcctcgagc aagtctattg gtgctgtttt 51541 tccaacagca tgtgcttgtt ttacatctct gtgtcacatt ttggtaattc tcccaatatt 51601 tcaaactttg tcattatttc tatatctgtt atggtaatct gtgatcagtg atctttgatg 51661 tcactattgt agttgttttg gggcaccatg aagtgcaccc atgtaagatg gcaaacaatc 51721 aataaatgtt gtgtgtgttc tgactgctcc atggactgcc tgttcctgag acacaataat 51781 gtatatataa caattatata tatatatatt tataacaatt atatatatat atattttttt 51841 tttttttttg aggcagagtc gcactctgat tgcccaggct ggagtgcaat gatgtgattt 51901 cagctcactg caacctctgc ctccccaggc tcaggtgatt ctcccacttc agcctcccaa 51961 gctgggacta caggtgtgca ccatcacacc cggctaattt tttttttgta tttttaggag 52021 agacagggtt ttgccatgtt gcccaggctg gccttaaact cctagactca aacaatccac 52081 ctgcctcagc ttcccaaagg gctgggatta caggcatgag ccactgtgcc cagcccaaga 52141 cacaataata ttgaaattaa gccaattaat aaccctacaa tggcctctaa gtgttcaagt 52201 gaagggaaaa gtcccacgtc tctcacttta aatcaaaatc tagaaatgat taagcttagt 52261 aaggaggaca tattgaaagt caaggccaaa agctcacctc tgcaccagtt agccaaattg 52321 cgacttcaca ggaaaagttc ttgaaggata tttaagctct actccaggga acatgcaaat 52381 gaagagaaaa caaagcagcc atattgctaa tatggagaaa gtttgagtgg tctggagaaa 52441 agatccaacc agccacaaca tttccttaag tcaaagccta atccagagca agactctaac 52501 tctcttcaat gctatgaagg cggagagagg tgaggaagct gcagaagaaa agtttgaagc 52561 tagcggaggt tggtttgtga ggtttaatga aagacaacat ctccataaca taaaaatgca 52621 agatgaagca gcaagtgcaa agggagaagc tgtggcaagt tatccagaaa atctagataa 52681 gataattgat gaaagtgtct acacgaaaca acagattttc agtgtagaca aaacagtctt 52741 atgttggaag aagatgccat ccaggacttt cacagctaga gaggagatgt caaggcaagc 52801 tgcaaagctc cacaggacag gctgactctc tttttagagg tgaatgcagc tgatgacttt 52861 aagttgaagt aaatgttcat ttactatttt gtaaatcctg gtgtcattaa gaattatgcg 52921 aaatctactc tatctgtgct ccataaatgg aacaataaag cctggatgac aacacatctg 52981 tttacagcat ggtttactga atatttcaag cccactattg agaactattg ctcagaaaaa 53041 aagattcctt tcaaaatatt actgctctgc accatgtcga tcaagagctg tgttggagat 53101 gtacgagaat attcatgttg ttttcatccc tgctaacaca aacatccatt ctgcagtcca 53161 tggaccaaga ctttcaagtc ttattaagaa atatatttca taaggctatt aagaaatagc 53221 tatatatata tatatatata gccttatata gtttatatag ctaccattga tagtgattcc 53281 attgatggat ctgagcaaag caaattgaaa agcttctgga aagtagtcat tattctagat EPI-109 863

53341 gccattagga acatttgtaa ttcatgggag gaggtcaaaa taccaacatt aacaggagtg 53401 tgaaagacat tgattccaac ccccatagat gactttcagg ggttcacgtc ttcagtggag 53461 gaagttgctg tagatgtggt ggaaacagca agagaactag aactagaagt ggagcctgaa 53521 gttgtgactg aattgccgca ctctcatgat caaacttgaa cagatgaaga gttgcttctt 53581 acatatgagc agtgaaagtg gtctcttgag atggaatctc ctcctggtga agatgctgtg 53641 aacacggtta aaatgacaac aatcgattta gaatattaca taaatttagt taataaagca 53701 gtggcagggt ttgagaggat tgactccaat tttgaaagaa gtgggtaaaa tgctatcaaa 53761 tagcatcaca tggtatggag aaatcttttg tgaagggaag agtcgaccaa ggtggcaaat 53821 tgcattgtca tcttatttta agaaattgcc acagccaccc ccagctttag caaccaccac 53881 cctgatcagt aagcagccat caacatcaaa acaagaccgc catcctcttc agcaaaaaca 53941 ctatgacttg ctgaaggctc agatgatggt tagcattttt agcaatacaa tatttttaat 54001 taaggtatgc acattggttt ttctgacata atactattgc atacttaata gactacagta 54061 taggataaac acaactttta tatgcactgg gaaaccaaaa aggttatttt tgagatattt 54121 gctttactgt ggtggtctga agctgaactc acaatctcac caaggtgtgc ctgaacctct 54181 ttagctaact ggccactgcc acagtccact ctgtgttggt caagatgccc cagagtggca 54241 ggcacactgt gtggtcacat ccaagggcct agatatggtg ggggctccaa atggatctag 54301 atatgtgaga tctctctttg atttgacttc ttccaaccca ccattttctg ggtgctgggc 54361 tcatctcacc cagaaagtag gacccaatgt gacagttcct gcccagttcc ctcctgtggt 54421 agccacttga cccaggggca ctcttgatcc ttgcagcctc acttacacac cctatctcta 54481 cccctattaa ctctctccaa tccccactcc ccctgctcag cttgtctgct gcccagtggg 54541 ggccccaccc atgctggcct ctccttttgc aagtccccat tcctcatatg gtttcttcag 54601 agcccctttc tttggctttg aggagagatg ccctcactcg cttccccacc aatcctgccc 54661 acttctacaa tccattcatt atcctaattg cctccgtata cagactggag tgagaggagt 54721 tgatgtgatg ggtgtggata cagggctggt gctgtcatct tctagtaagc cctgggagag 54781 gtgtctgagc ccaggtgtca gtggttttct ttggaactgt gagtgcataa cacttctttg 54841 ccttcagcct taggccatag ttgctagttc tgggacaacc agaaaagccc tacataatct 54901 cgtgttatgt gcagagctga gtatagagct ccaggtatga tctgactcac ttaagatcac 54961 agtgagtcta ttgtattgtt gaactgttag cttagacatc tgttactgta cctacatggc 55021 actagcctca cgcctagaca ccgatctgaa agaaatcccc taaatgcata gagaagactt 55081 ctcagctgag ctaaggggct cccaccaggt ttgagcctat ctaatgaatc catgaggtag 55141 acagcctgca catgtccact tggtttgatg aattgcacaa atccctatgg gggatgtggt 55201 tcatgggctg ggaagtgggt taccctggga aaggtctaca ggacagaggc agggatggag 55261 acaacagcat ggtgagttcc caacccaccc acgatgatag gtgtctgagg cagaaggtaa 55321 agaggctgtc acctggtggg tgtcataaga ctcaagtgtc attgttgagg cacatgggta 55381 acaaagcgtg gcactggatg ggggtagatt cttcctattt ctgtgaggat cagggggact 55441 ccctggctct cctgctaaag gtggctctag ggacaggaag agtgtacttc ttgacaggga 55501 tgtcagagca ctgatggtga caatcagtgt gacactgctc acatgactga acaaccgaga 55561 agagcccgac tgtctactga acaacgggaa gagcccgact gtcaatgacg gagctctgtt 55621 aaatatagtt aaggctattt tgttgaatga atgaagccag acaggaaaga ggacagtatc 55681 tttaatccat ttatagaagt taaagacagg cttatttaat ctctatgaag acagagtggc 55741 ccttacctct gggtggagca aaaggcacct tctgaagtga tagggatgtt ccttatcatc 55801 ttgatccgga gtggtagtta catgcatgta tgcatatcaa aactcaccaa gctgtaccac 55861 taagtgtgtt cttcctcaat aaaaataata aagaactaca cttataaaga attttttaat 55921 aatataggaa aatgtctac^'a ctataatctt tagctaaaaa aaaaaaaaaa gaagccgcct 55981 acagaatggt atatgcatga gaacaattaa tcgaaaagtg catgggaaaa gtcaggattg 56041 aaacatcatg ttttaaaaga cattgttttg atactgtgag aatgtaccta agtttttcct 56101 tttttctgtt tttcccaatt ttatacaatg agcatgtgtt ggttttataa ttagacattt 56161 tgtttgtttg gtttggtttt gagacacagc ttgctgtcac ccaggttgga gtgcaatggc 56221 ccaatcttgg ttcactgcaa cctccatctc ctgggttcaa gagattctcc cacttcagcc 56281 tcctgagtag ctgggactat aggggcgcac caccacatcc agctaatttt gtgtattttt 56341 agtagagatg gggtttcacc atgctggcca ggttggtctc aaactcctga cctcaagtta 56401 tccactcgcc ttggcttccc aaagtgctgg gattataggc atgagccacc gcacttggcc 56461 tagacatttg tttttaaaaa taaaagattc atttgctctt tttacagccc gtctcactgt 56521 tgactgatat tgaccaggag tcaactcagg ccccagggat tttcacaaca gctgctgtat 56581 ggcagggttt ctgctcactg tgctcatgta gttggccctt gcacccaaag tgaataatta 56641 acattctccc catcctgttg acgatgctct gaaaatatgg tccagaaatg gtgtgagcaa 56701 ggagacagca aagcaatgct tggaacatag gtgcagtgac tagacatggg gcagctgttt 56761 aaagacaaaa aggccccaaa aaggagggat ggcacgaaac accctccaat atgggcatgg 56821 agtctagagt gacaaagtga tcaaaagttc atttcctatg gggtgtccga atgtacttaa 56881 taataaaaag agaacaagag ccatgcaaac tgagagggac aaagtagaaa gagtagcaga 56941 caccaagcaa ctaagtcaca gcatgataag ctgctagctt gttgtcatta ttgtatccag 57001 aacaacattt catttaaatg ctgaagaatt tcccatgggt ccccactttc ttgtgaatcc 57061 ttgggctgaa cccccctgtc ctgagtggtt actagaacac acctctggac cagaaacaca 57121 aaagtggagt aacacacact gcaaagctgt gcttccttgt ttcagcctgt gaatcctcac 57181 cttgtttccc atctagccta tatttttcaa actaacttgg ccatagaatc atgtagtatt 57241 tagggtggaa gctgccccag gtctagcacg tcatttaaca gatgaggaaa tggaagcttg 57301 ggcagtggaa gtatcttgcc gaggtcacac agcaagtcag cagcacagcg tgtgtgactc 57361 cgagcctgct ccgctagccc acattgccct ctgggggtga gtatgtcttc acatcctcca 57421 ataccctaat gacagacaaa cagaacatgg caaagcctca gctctgcatg gtgaaagtaa 57481 gaaccagcaa ttgccacaaa cagaaataca gtgttggtcc ggcagcctcc gggggttctg 57541 cacaagtgga ttaccagtga atacaaggct atctatcttt cgaaaaacca acgttgtatt 57601 tatgctattt tctataaaat tttatattaa tttatttgtt acctattttt gaactctttc 57661 aaaagcacac tttatatttc cctgcttaaa cagtcccccg agggtgggtg cccaaaaggc 57721 tctacacttg ttatcattcc ctctccacca caggcatatt gagtaagttt gtatttgggt 57781 ttttttaaaa cctccactct acagttaaga aaactaaggc acagagcttc aataatttgg EPI-109 864

57841 tcagagccaa gtagcagtaa tgaagctgga ggttaaaccc agcagcatga ctgcagttct 57901 taatcaatgc cttttgaatt gcacatatgg gatgaactag aacattttct cgatgattcg 57961 ctgtccttgt tatgattatg ttactgagct ctgttgtagc acagacatat gtccctatat 58021 ggggcggggt tgggggtgtc ttgatcgctg ggctatttct atactgttct ggcttttccc 58081 aagcagtcat ttctttctat tctccaagca ccagcaatta gctttacctt ttcagcttct 58141 agtttgctga aactaatctg ctatagacag agactccggt gaaccaattt tattaggatt 58201 tgatcaaata aactctctct gacaaaggac tgctgaaaga gtaactaaga gtttgatgtt 58261 tactgagtgc atagtatgtg ctagatgctg gccgtggatg cctcatagaa tcctcccaac 58321 aactcatgaa atgactactg tcattcagcc caatacccag acgagaaagc tgagggtaag 58381 acaggtttca agcttggcag tctgactaca gaggccactg gcttagcccc tgggttagtc 58441 tgcctctgta ggattggggg cacgtaattt tgctgtttgg ggtctcattt gccttcttag 58501 agatcacaag ccaaagcttt ttattctaga gccaaggtca cggaagccca gagggcatct 58561 tgtggctcgg gagtagctct ctgctgtctt ctcagctctg ctgacaatac ttgagatttt 58621 cagatgtcac caaccaccaa gagagcttga tatgactgta tatagtatag tcataaagaa 58681 cctgaacttg accatatact tatgtcatgt ggaaaatttc tcatagcttc agatagatta 58741 tatctggagt gaagaatcct gccacctatg tatctggcat agtgtgagtc ctcataaatg 58801 cttactggtt tgaagggcaa caaaatagtg aacagagtga aaatccccac taagatcctg 58861 ggtccagaaa aagatgggaa acctgtttag ctcacccgtg agcccatagt taaaactctt 58921 tagacaacag gttttttccg tttacagaga acaataatat tgggtggtga gcatctgtgt 58981 gggggttggg gtgggatagg ggatacgggg agagtggaga aaaagggggc acagggttaa 59041 tgtgaagtcc aggatccccc tctacattta aagttggttt aagttggctt taattaatag 59101 caactcttaa gataatcaga attttcttaa ccttttagcc ttactgttga aaagccctgt 59161 gatcttgtac aaatcatttg cttcttggat agtaatttct tttactaaaa tgtgggcttt 59221 tgactagatg aatgtaaatg ttcttctagc tctgatatcc tttattcttt atattttcta 59281 acagattctg tgtagtggga tgagcagaga acaaaaacaa aataatccag tgagaaaagc 59341 ccgtaaataa actttcagac cagagatcta ttctctagct tattttaagc tcaacttaaa 59401 aggaagaact gttctctgat tcttttcgcc ttcaatacac ttaatgattt aactccaccc 59461 tccttcaaaa gaaacagcat ttcctacttt tatactgtct atatgattga tttgcacagc 59521 tcatctggcc agaagagctg agacatccgt tcccctacaa gaaactctcc ccggtaagta 59581 acctctcagc tgcttggcct gttagttagc ttctgagatg agtaaaagac tttacaggaa 59641 acccatagaa gacatttggc aaacaccaag tgctcataca attatcttaa aatataatct 59701 ttaagataag gaaagggtca cagtttggaa tgagtttcag acggttataa catcaaagat 59761 acaaaacatg attgtgagtg aaagacttta aagggagcaa tagtatttta ataactaaca 59821 atccttacct ctcaaaagaa agatttgcag agagatgagt cttagctgaa atcttgaaat 59881 cttatcttct gctaaggaga actaaaccct ctccagtgag atgccttctg aatatgtgcc 59941 cacaagaagt tgtgtctaag tctggttctc ttttttcttt ttcctccaga caagagggaa 60001 gcctaaaaat ggtcaaaatt aatattaaat tacaaacgcc aaataaaatt ttcctctaat 60061 atatcagttt catggcacag ttagtatata attctttatg gttcaaaatt aaaaatgagc 60121 ttttctaggg gcttctctca gctgcctagt ctaaggtgca gggagtttga gactcacagg 60181 gtttaataag agaaaattct cagctagagc agctgaactt aaatagacta ggcaagacag 60241 ctggttataa gactaaacta cccagaatgc atgacattca tctgtggtgg cagacgaaac 60301 attttttatt atattatttc ttgggtatgt atgacaactc ttaattgtgg caactcaaac 60361 tacaaacaca aacttcacag aaaatgtgag gattttacaa ttggctgttg tcatctatga 60421 ccttccctgg gacttgggca cccggccatt tcactctgac tacatcatgt caccaaacat 60481 ctgatggtct tgccttttaa ttctcttttt gaggactgag agggagggta gcatggtagt 60541 taagagtgca ggcttcccgc attcaaaatc ggttgcttac tagctgtgtg gctttgagca 60601 agttactcac cctctctgtg cttcaaggtc cttgtctgca aaatgtgaaa aatatttcct 60661 gcctcataag gttgccctaa ggattaaatg aatgaatggg tatgatgctt agaacagtga 60721 ttggcatcca gtatgtgccc tcgaggcctc ttaattatta ctggcttgct catagtgcat 60781 gttctttgtg ggctaactct agcgtcaata aaaatgttaa gactgagttg cagctgggca 60841 tggtggctca tgcctgtaat cccagcattc taggaggctg aggcaggagg atcgcttgag 60901 cccaggagtt cgagaccagc ctgggcaaca tagtgtgatc ttgtatctat aaaaataaac 60961 aaaattagct tggtgtggtg gcgcctgtag tccccagcca cttggagggg tgaggtgaga 61021 ggattgcttg agcccgggat gatccaggct gcagtgagcc atgatcgtgc cactgcactc 61081 cagcctgggc gacagagtga gaccctgtct cacaacaaca acagcaacaa aaaggctgag 61141 ctgcaccatg cttgacccag tttcttaaaa ttgttgtcaa agcttcattc actccatggt 61201 gctatagagc acaagatttt atttggtgag atggtgcttt catgaattcc cccaacagag 61261 ccaagctctc catctagtgg acagggaagc tagcagcaaa ccttcccttc actacaaaac 61321 ttcattgctt ggccaaaaag agagttaatt caatgtagac atctatgtag gcaattaaaa 61381 acctattgat gtataaaaca gtttgcattc atggagggca actaaataca ttctaggact 61441 ttataaaaga tcacttttta tttatgcaca gggtggaaca agatggatta tcaagtgtca 61501 agtccaatct atgacatcaa ttattataca tcggagccct gccaaaaaat caatgtgaag 61561 caaatcgcag cccgcctcct gcctccgctc tactcactgg tgttcatctt tggttttgtg 61621 ggcaacatgc tggtcatcct catcctgata aactgcaaaa ggctgaagag catgactgac 61681 atctacctgc tcaacctggc catctctgac ctgtttttcc ttcttactgt ccccttctgg 61741 gctcactatg ctgccgccca gtgggacttt ggaaatacaa tgtgtcaact cttgacaggg 61801 ctctatttta taggcttctt ctctggaatc ttcttcatca tcctcctgac aatcgatagg 61861 tacctggctg tcgtccatgc tgtgtttgct ttaaaagcca ggacggtcac ctttggggtg 61921 gtgacaagtg tgatcacttg ggtggtggct gtgtttgcgt ctctcccagg aatcatcttt 61981 accagatctc aaaaagaagg tcttcattac acctgcagct ctcattttcc atacagtcag 62041 tatcaattct ggaagaattt ccagacatta aagatagtca tcttggggct ggtcctgccg 62101 ctgcttgtca tggtcatctg ctactcggga atcctaaaaa ctctgcttcg gtgtcgaaat 62161 gagaagaaga ggcacagggc tgtgaggctt atcttcacca tcatgattgt ttattttctc 62221 ttctgggctc cctacaacat tgtccttctc ctgaacacct tccaggaatt ctttggcctg 62281 aataattgca gtagctctaa caggttggac caagctatgc aggtgacaga gactcttggg EPI-109 865

62341 atgacgcact gctgcatcaa ccccatcatc tatgcctttg tcggggagaa gttcagaaac 62401 tacctcttag tcttcttcca aaagcacatt gccaaacgct tctgcaaatg ctgttctatt 62461 ttccagcaag aggctcccga gcgagcaagc tcagtttaca cccgatccac tggggagcag 62521 gaaatatctg tgggcttgtg acacggactc aagtgggctg gtgacccagt cagagttgtg 62581 cacatggctt agttttcata cacagcctgg gctgggggtg gggtgggaga ggtctttttt 62641 aaaaggaagt tactgttata gagggtctaa gattcatcca tttatttggc atctgtttaa 62701 agtagattag atcttttaag cccatcaatt atagaaagcc aaatcaaaat atgttgatga 62761 aaaatagcaa cctttttatc tccccttcac atgcatcaag ttattgacaa actctccctt 62821 cactccgaaa gttccttatg tatatttaaa agaaagcctc agagaattgc tgattcttga 62881 gtttagtgat ctgaacagaa ataccaaaat tatttcagaa atgtacaact ttttacctag 62941 tacaaggcaa catataggtt gtaaatgtgt ttaaaacagg tctttgtctt gctatgggga 63001 gaaaagacat gaatatgatt agtaaagaaa tgacactttt catgtgtgat ttcccctcca 63061 aggtatggtt aataagtttc actgacttag aaccaggcga gagacttgtg gcctgggaga 63121 gctggggaag cttcttaaat gagaaggaat ttgagttgga tcatctattg ctggcaaaga 63181 cagaagcctc actgcaagca ctgcatgggc aagcttggct gtagaaggag acagagctgg 63241 ttgggaagac atggggagga aggacaaggc tagatcatga agaaccttga cggcattgct 63301 ccgtctaagt catgagctga gcagggagat cctggttggt gttgcagaag gtttactctg 63361 tggccaaagg agggtcagga aggatgagca tttagggcaa ggagaccacc aacagccctc 63421 aggtcagggt gaggatggcc tctgctaagc tcaaggcgtg aggatgggaa ggagggaggt 63481 attcgtaagg atgggaagga gggaggtatt cgtgcagcat atgaggatgc agagtcagca 63541 gaactggggt ggatttggtt tggaagtgag ggtcagagag gagtcagaga gaatccctag 63601 tcttcaagca gattggagaa acccttgaaa agacatcaag cacagaagga ggaggaggag 63661 gtttaggtca agaagaagat ggattggtgt aaaaggatgg gtctggtttg cagagcttga 63721 acacagtctc acccagactc caggctgtct ttcactgaat gcttctgact tcatagattt 63781 ccttcccatc ccagctgaaa tactgagggg tctccaggag gagactagat ttatgaatac 63841 acgaggtatg aggtctagga acatacttca gctcacacat gagatctagg tgaggattga 63901 ttacctagta gtcatttcat gggttgttgg gaggattcta tgaggcaacc acaggcagca 63961 tttagcacat actacacatt caataagcat caaactctta gttactcatt cagggatagc 64021 actgagcaaa gcattgagca aaggggtccc atagaggtga gggaagcctg aaaaactaag 64081 atgctgcctg cccagtgcac acaagtgtag gtatcatttt ctgcatttaa ccgtcaatag 64141 gcaaaggggg gaagggacat attcatttgg aaataagctg ccttgagcct taaaacccac 64201 aaaagtacaa tttaccagcc tccgtatttc agactgaatg ggggtggggg gggcgcctta 64261 ggtacttatt ccagatgcct tctccagaca aaccagaagc aacagaaaaa atcgtctctc 64321 cctccctttg aaatgaatat accccttagt gtttgggtat attcatttca aagggagaga 64381 gagaggtttt tttctgttct ttctcatatg attgtgcaca tacttgagac tgttttgaat 64441 ttgggggatg gctaaaacca tcatagtaca ggtaaggtga gggaatagta agtggtgaga 64501 actactcagg gaatgaaggt gtcagaataa taagaggtgc tactgacttt ctcagcctct 64561 gaatatgaac ggtgagcatt gtggctgtca gcaggaagca acgaagggaa atgtctttcc 64621 ttttgctctt aagttgtgga gagtgcaaca gtagcatagg accctaccct ctgggccaag 64681 tcaaagacat tctgacatct tagtatttgc atattcttat gtatgtgaaa gttacaaatt 64741 gcttgaaaga aaatatgcat ctaataaaaa acaccttcta aaataattca ttatattctt 64801 gctctttcag tcaagtgtac atttagagaa tagcacataa aactgccaga gcattttata 64861 agcagctgtt ttcttcctta gtgtgtgtgc atgtgtgtgt gatgtataca aagagagaga 64921 taattgtatt tttgtatttt cttttaaata atttttaaaa ttgacccttt tcctgagaca 64981 aattgccaga atagtttgta tttagagatg gtacctctaa gagtaaggtt gctggttgct 65041 gagcaattga cttgaaaact tttaaaattc aaattttaat tccactactc aaaagaattg 65101 ccatgtttta aaaaagagaa ttggtgccat aagttagttg tctatgtttg aaaatgaaga 65161 agatatgcaa cgtcatggcc tggtcactta cccgcagccc tgagttgtag gcacatcata 65221 tgtgagaatg aggatgcttt tctttcattt aaaatccctc cccaaaactt ggctctaatt 65281 gcagtcatga caatcatgta catttggatt tatgtgcacg agtctcttac cctgagagag 65341 gacaggtgct acaggtggag gggacccgtc tgggtcacgt tcacattttg aacatgctgg 65401 ttttcagtca ctgcacactc atctcccagc gcaggtcatg ggcagcagat gcaaaagctg 65461 cccgtggtcc tatttggagg tgcatgaaat gagcagaaga cagaatagct tgatctgact 65521 agaagggcag cttgtcccta ccaagacttg aaggattgcc tttcatctgt tagggtaaaa 65581 ggtagaatga accaaggaag ggcaggaggg ggctggggtt agggtagaag gaaggggcca 65641 tggagaaggg agatccatcc cataggagga aggcagtgcg gcagggaggt ttgaaggtat 65701 cagcttttgt ggctgacata catgcagtca tgtcaattgc tcgtttttcc ttttccatct 65761 tattaaatgt cttccaatgt tagcacgaag aaaagctatt tgcagtgttg ccagcctttc 65821 cagagcccgt ccccattacc tccccaggcc catgccttta ctccttggag tttcaactca 65881 cgaccttcag gatctgactt tattcaccaa ctctggggtg aacgtacctt ctgtctccac 65941 ccagaggtct ctatcaaaga ggagattgca tgccatggat aaagtcaaag tagaggtgac 66001 tgtccttagg aagagtaatg tgaaaattca taaactggga ttctgtttac attttgtact 66061 ccaggggttc ttagtttaaa tcgctctgaa taaattaaga tgcaatggca tttcaactgt 66121 tatgattaaa tttacaaatc atttattttc tatcacgggg agagatagag ctccaaatgc 66181 aaacataact gctcaagtgt taacacttat aatgaaaaca taagaattac caccaactac 66241 cctgggggct agaagcagaa atgtgaacca gaaaacaaat catgaacttt cctttttttt 66301 tttgagatgg agtctcgctc tgttgcccag gctggagtgc aatggtgcga tctcggctca 66361 ctgcaaccac tgcctcccgg gttcaagcaa ttctcctgcc tcagcctcct gagtagctgg 66421 gactacaggc atgcaccacc acgcctgggt aattttttgt atttttagta gagacagggt 66481 ttcaccgtat tagccaggat gctctcgatc tcctgacctc gtgatctgcc cgcctcggcc 66541 tcccaccgaa gtgctgggat tacaggcatg agccactgtg cccggccaac aaatcatgaa 66601 ctttctaact gcagttcctt gtagcttgtt aacacatcca cttacttatt gtcagagtac 66661 gtggagattt tccacaaccc tcggggataa ggctgaacag aagaggcaaa aacgtgaaaa 66721 catttcgata gctcctatac tttgaaataa aattcactgt aaaagttgct tgtatttttc 66781 caaaacagag tcaaccctta atatttaaga ttctgtatac aaatacatat ttttatataa EPI-109 866

66841 ttaatatata ttgtcatatg acatatatct ttatattaat atgcatgcat ataatatata 66901 tttccttcct aattttctat aagcaatttt acaagactga cttctatttg cctccttatt 66961 gttactacgt ggtttgataa tccgttttgt gtcattgtga ttctgtcatg ttttggggac 67021 ttatttttgt ttctctgggt ggtcactagt ttttttaaag cattcatgga agagtgtgaa 67081 tcttttacaa gctaggaagc catggcaagc cttgggtcat actgcccccg cgaggccaca 67141 ttggcaaacc agcaagggtg ttcaacttcc agacttggcc atggagaaga catacgagga 67201 ggcttttcac attcagctct ttaatgtttg tctctgccgg caccatccca gttgtgaata 67261 agaggtattt ccacagcggc tcagggtagg tagtgcacag ctcacattca tcatttctga 67321 aaaccgagag gagtctccat tcggggtaca ggttgatgcc tgtcgtggaa tgaaggttcc 67381 aacacccaga ccaatctctg cagtgtgctg ctctcatgag cttgcaacaa gatcagaaaa 67441 tgttttgtga ctaagcattt ttcatattgc ataaaatgct tcaagctcct cccttgtttc 67501 tctctataat cctgtatatc tgatgattgt gggtaccaag tgtttgaaat aatcaaatgt 67561 gatttgatgt tggtaaattt cttttttttt ttttttttac ttctattttt tttattatac 67621 tttaagtttt agggtacatg tgcacattgt gcaggttagt tacatatgta tacatgtgcc 67681 atgctggtgc actgcaccca ctaactcgtc atctagcatt aggtatatct cccaatgcta 67741 tccctccccc ctccccccac cccaccacag tccccaaagt gtgatattcc ccttcctatg 67801 tccatgtgat ctcattgttc aattcccacc tatgagtgag aatatgcggt gtttggtttt 67861 ttgttcttgc gatagtttac tgagaatgat ggtttccaat ttcatccatg tccctacaaa 67921 ggacatgaac atagcaaaga cttggaacca acccaaatgt ccaacaatga tagactggat 67981 taagaaaatg tggcacatat acaccatggt aaatttcttt atcattcgca ctctcctttc 68041 tctattattg ttattgtaac tgaaccgcag attagtcact cattgcttgc agaatccaat 68101 taacaagagc gaggtcagat ataaagaaaa tgatttattc caaacctcct tcagggaaga 68161 ggtgcagcct cctgcctcta aatgcactgc ttcgccaggc gtggtggctc acacctgtaa 68221 tcccagcact ttgggagacc gaggagggca gatcacttaa ggtcaggagt tcaagaccgg 68281 cctggccaat atagtgaaac ccctgcctct actaaaaata caaaaaatta gccagacgtg 68341 gtggcgggtg cttgtaatcc cagctactcg ggaggctgag gcaggagaat cgcttgaacc 68401 tgggaggtgg aagttgcagt gagctgacat ctagccactg cactccagcc tgggtgacag 68461 agtgagactc tgtctcaaaa taaataaata aataaataaa taaataaata gtaaatgcac 68521 tgctttgctt ttggagcaga aagcaggcac tttgaaaagg caggggagga agtgagcaag 68581 ggcagggggt ctgcacactg gcatggtgcc tgatctatcc aggcagttga attggcactt 68641 tcataggcag aaataagttg aaaaagtggc ctaaaactct ctaggtggga gtggatagtg 68701 ggcatgcctt caacctgcct ttctggaggg tgagttccat ggcaaccccc tgaagggtga 68761 gagttccatg gagatcatgc tttggtctgt aaatcagctg ttaactctct agaaagttct 68821 gtcttggagc atatagttag atgaacttgc cctgtaaaga atgtctggtg aaggggaagt 68881 aaaaggtgag atttgcattt ctaaagggct aagtagaacg tggggtacaa gaggaaagga 68941 gaaaagagaa aataatttaa aaaataattg taacttattc ccttttactt agaaaaaagg 69001 gaatactcag ttacattatc acctcgttta catcaaaccc tcttatggaa tcctatggtt 69061 tgaaaacaaa aaggttgttg aggaccagtg agcccaaccc ctttgcttta taaatgaaga 69121 gcattgcctg ccctaagccc cagagactct gatgtcgtgg gtctggagtg ggctccaaca 69181 gcggcatgtt ttgatggtgc ttcccagtgg cacgccagcg atgagccttt gagtagggaa 69241 agtaggagca ctcgtgactc ccttcacgat cagcacctgt gtgctaataa attcacaaaa 69301 gccaacatat tggagtcact cagggagttt tacaaatagt gaggttaaat ccaacctcaa 69361 atagttctga ttcgatctgc ctgcattgct gccctgtggt tccccactgt agaagctccc 69421 caggtgattc taagtgtagc caagtctgag aaatactgcc taaagcctgt tggactgaca 69481 gcaagggctg ttgtctgagc aagactttgc ctggcctggg gtggcatgtg caccaggaag 69541 agtctcaact ttcataacag aacattcccc aagctggttt ttttaaagca tgtgaatcta 69601 gacttcattg gcaataccaa agatctgtat ttgaggctcc aagtatttca ctttcatttt 69661 tggttttggg ttatgttttc acccttcctt tccaagtgaa aagtaaacag aagtgggatg 69721 tctggcgccc atgctgagct tggcaacttc aaattcaata gagaagaagt ctcttgtata 69781 gaaaagggcc tgtctgagat gtttctcaaa taaatataga ttttgcttat gtggctaaag 69841 gattcttctc cccccatttc cttatccctg cagtgagcca tccttcttaa ctctttccat 69901 gaaagcatta ttcctgaaga actgggaact catgccagcc ctgatcaggc aatgataatt 69961 ctgcagagaa ttagaattta gatttaaatt gtcaactctt atacatcctg gcatatggtt 70021 taaacacatg tacacacaca caaacacctc ctactattta ctgaagagca gatatctgat 70081 aacttaatct ttttggtttt gagtcaagac aattcctcct tttgaaactg cataccgctg 70141 aatataataa aatgtaatta agattaaaaa taagaaacta atgggagaat ttcaatattg 70201 tctctgttca ctttaaaatt cctctactta ggtttactgc cattaccaaa gactattcaa 70261 aaatcctttt taggagaatc ctaatggttt cctgacatat aatcaaataa ggactctgtt 70321 gattggctaa ctcaatcttc ctgtgccaaa aagcagagcc cagcagagaa gagggcaggg 70381 acttgaaagt cagactgact cgagttccag ccttggggct gtgggagctt gggcaagtga 70441 cttaacgtct ctggctctca ggatctaaaa ggatttccag tagtaatttg gggtgttact 70501 gatacaggag ctaaaaagaa attatttagg tggttagtga gggtcagaga gtcctcggta 70561 agatttgcct tttaacaaaa agcagcccca aaatcatttg tttgctaaca aagagaagcc 70621 tgtaaaattg agctgcagac atagataagc aagctggaag cttgcacggg tgaatgccgg 70681 cagctgtgcc aataggaaaa ggctatctgg gggccaggca tgttcaacat ggattctcca 70741 tcttcccttt tctttgtcaa ccaagtgtac agtaaaggaa caggcaacat ggcacgggcc 70801 aggtagagaa cccttctgca taataaaaga ttagggtgag atggccagct tcttcccgtg 70861 ctatgtaaat ggcatacctg gtccaaccag tcttttgggc cctgtgtaaa tcagacaccg 70921 cctcctcaag ttagtctata aaaccccatg cattttaccg tgaaactggg agatccactc 70981 ggaaccccct cctgcacgag agaccttttc tcttttgcct attacacttc cgctcttaaa 71041 ctcactgctc atgtgttagc atccttgatt tccttggcat gaggcaatga accttgtgta 71101 ttaccccata caaatgatgc tgcttcatta ctaatagcaa cctgacaggg ttgtgttggg 71161 gtataaatta tctagaccag ggagatccaa tataattttt ttgtaatgac gggaatgctt 71221 tgtatctgca tcatccaaaa tggtagccac caggccaggg tgaaatgtgg ccagtgtgac 71281 tgaggaactg aatgttttcc atgatttaat ttaaatgtgg ccaatggcta ctgtaggaga EPI-109 867

71341 cagtgtgagt ctggcatatt ataaataata aatattaata taatttgaac tttggcatca 71401 gtgtttccta gatttgaatt actatgcaag ttgcttactg tttccaagcc tcagctttct 71461 aatctgtaat tggggctaat aatagtatct gccttacagg tttgttcaga ggataaatga 71521 gaaattgcat gttgagggct taacacagtg cctggcacat aaaagctctg gtaacagtta 71581 gccactttaa taatttgcta ataatggcta tttcttcttc agattaggat gtgctccccc 71641 aaacagtgca cttagacata gcgggcaatc cagctcactc tctgcagtga gagagaagca 71701 ctggccgacc agagtcagcc aggggctcat gggtatgaaa tcaacagcat gattttgtaa 71761 gtaatggatg gaaagggcct cacaacttta tggcactgtg ttcaatttgc ttggtcttct 71821 gtagctcctt ttgaaagcct tttagggtgg attaacctgc taccaataat tctggtcaga 71881 tgtagactcc atagctcaaa gcaaactgag agagtgaggg cagcaggcca attccccacc 71941 ccttccttct ggactctgac agaagcttac actcaaggaa gagcaagtag gaattaacgt 72001 gttaagagct aggtaagcaa aacccaatga gaagttctgg caaagcccca tgggcagggg 72061 tggcttaggc acaggaaaca agtaggattt cataccacgc gcctcagtct acttccgggg 72121 ccctcatcct cagctgtgcc tatgcaaagg agagcaacca ataaacccca ccgccactct 72181 cctactgtgg aggccaggga tggccagggg taagagaggg atgggaagtg tttcctccag 72241 ccgtcctctg agaaggagag gaaactgggc agagcttctg tcctccttca agcagaaaca 72301 gaaacaaaag aaacccctaa gggggttctt acttcccctc tagttcagtt gtgcactaac 72361 catctgcagc tcaacattca gcattcattc attgattcag caaacattga aggagggcca 72421 gctatgtgcc agatgccaac tcatgccatg aaagagagtc cctgtcctta tgaaattcac 72481 tatttagaga gaaaagcaag caaaaaggca aagtttgaaa agtactgttg aagtggcatc 72541 attgtctggg gtgaatacct gaggtttgtg gtctcacgcc aagggaatca aggactcagg 72601 cacacaagaa gtgagtttaa gagcagaggt ttaataggca aaagaaagag aaaaaagaat 72661 agctctcttg cctgcacaga gagaggggca cctgagtgga tcttcctgtt ttgtggtgaa 72721 atgcaaggca ttttatagac gagcttgagg aagtggtgtc tgatttactt aggacccgag 72781 agattggtca gaccaggtgt gatgtttaca tagcatacaa agaagctggc catcccatcc 72841 taatctttta ttacgcagac ggggtctata cctggctggt gccatgttgt ctgttcctta 72901 ctgtacacgt ggttgacaaa gaaaagggaa gatgaagaat ccatgttgaa catgcctggc 72961 ccccagatag tcttttccta ttggcacagc tgccggcatt cactcttgca agcttccaga 73021 ttgcttatct atgtctgcag cccaatttta caggttgctc tttgctagaa aagaaatgat 73081 ttgggggctg cttttcatta aaaggaaaac cttaccaagg ttaaaaagaa aaaaatttct 73141 ttttaatgcc tatgttactg tgaacagtgt cgggataagg ctctgagagc cagatgagga 73201 tgagttatcc aatccaagga tgggggtctg gaggaaaaaa tcctagagag cattgctgca 73261 gttgaataag gattagttag aagctactga gtggagcata ggagtaggaa ctcttatgca 73321 aatgtgcaga ggtgaaataa agcaaggtat agtccaggtg cctaaagtag cacagctgac 73381 ttgagataga tgatagatag gtagatagat ggatagggta catagatgat agatagatag 73441 atagatagat agatagatag atagatagat agacagacag acagacactg gtgtgagtgt 73501 gggtgtgtgt gtctggctgc gtgcatgcat tcctcctgca ggagatcagg agcagtgggc 73561 agtatggagt gacaagaaga ttgggaggta ctccttctag ccctcccctc tgctctgccc 73621 tccactggag cagaagcaaa gcatatggtg aaggggaaca aggagtctcc ccagcacagt 73681 acccgagtgc attagctatt tatcactcca cagtccccat tcacgtgtta attcagcatt 73741 tattgaatgc ttactgtttg caatgtctat gtcaagctgt caagtgtagt ttttattcta 73801 caggccacag gcacccccta actgtgttaa acaagatggt agtattgaga caggaataat 73861 aagggtggtc acaggagaat ggaagattcc aggcagcagt ttgactagta aaaaaggaaa 73921 ctgttgaaat agctgcataa tccaggggtc aataagaacc tgagaaccag ggtgtgagcc 73981 aaggctggtt aaaagcaact ggatccaata tggtgctgag tttctcctag gttttgcctg 74041 gaacctcatt atatgctcaa taacatacca aatcacacac ccaccagggc cattccattt 74101 cctggaacac tcatgtttgg tgtaaaaatg ggtggcacca cagctctgag aaatctttac 74161 ctttttcagg aaacttcatg aatattccat cctttggtta aagaaaccca taatgtagaa 74221 gccccaaacc ctactgggc^'g caactctctc tctcttgagt atgcctgcac ttccctttat 74281 tatttattta tttatttatt atttatttat ttatttttta gatggagtct ggctctgtca 74341 cccaggctgg agtgcagtgg cgcagtctca gctcactgca agctctgcct ccagggttca 74401 ggccattctc ctgcctcagc ctcctgagca gcagggacta caggcgccca ccacaacgcc 74461 tagctaattt tttgtatttt cagtagagat ggggtttcac catattttat tttatttttg 74521 agacagggtc tcactttgtt ggctcgctgc aacctctgcc tcccaggctc aagcaatcct 74581 ccaacctcag ccccccaagt agctgggagg acagacgtgc accaccacac ctggctaata 74641 ttttgtattt ttttttgtag agacagggtc ttgccatgtt ccccaggctg gtcttgaact 74701 cctggactca ggtgatcagc ctgcctccac cttccaaagt gctaggatta caggaatgag 74761 ccaccccacc cgaccacact cccatttctt gagtgtgtgc attttgctct gcaataaatc 74821 tctctacttt cacttttctc tgactcgtcc ttgaattcct tcttgtgaca gcgtcaacag 74881 cctggacacc aggtgcagtc aacgtctcac cagtgtttag ggacctcccc taatccactg 74941 gtatcagcat gatcagactt gctttttcag aaaaagcctt ctgtccatag accaaaggga 75001 agtgactcag agaaggggca ggaggaatca caagctccct gcctgaccag gcctggacta 75061 tggcagagac agtgagatgg tgagaaagca agggtagaca gccagccaaa tccagaatat 75121 agaaagttct acaggaaaag gtggggccaa ggtgggacag ggggaaagga attgttgcac 75181 attaacagtg caatgcagag cactggtctt gtttatgtcc aggttagaac aaaccaatga 75241 gaaagcacat ctttgagaca actggagaaa tttgaacact gactagatat aatattatgt 75301 taattatgct ttaatttggg gtacaataat gcttttgtag ctatttctaa agagtcctta 75361 tctcttaagg atacactcta aaatactagt ggattaagtt atatgatgtt tagactcttt 75421 ttaaaataat ccagtggggt gagaggcaga gggaagggag aggagcatag aggaaacagt 75481 gttggccata tgtttgtaat tgttaaaact gagtgatggg aatatggaga tttaacatat 75541 taatactatt ttctgcccat gtaatatttg aatattttca taataaaatt gagagagaga 75601 taaagaaaga aaagagaaaa gaagagaaga gagaagagat aagggaagtg gaggaaaaag 75661 agctttcttc aaggaccatt gtggtggaca caaatgaaag ataccccctt cctactatga 75721 attctaggtg tgtactaccc aagatgagtc aatcggatcc tagcttccag aaatcgtgag 75781 catgatgcag ccctacagac gcagtgccct ggaaaggaga cccatgacca tccaaggaag EPI-109

75841 atgtcccatc acagaactgc cctgggtcat gtgttttcca agtccacatg tccggtagtt 75901 ccttctttcc tatgaccaat gccaccagtc ttccagcact gtcctttatt gctaggcaaa 75961 cctgagccat cctcttcttc ttgcaacttg tgcctgaagt aacatggaca caaagtcccc 76021 acttttccca cattctcaga atgaagtagt tctccctcca cactttaggt gctagaggca 76081 agtggattgc ttgagctcaa gagttcaaga ccagcctgag caacatggca aaaccccgtc 76141 tctacaaaaa atacaaaaat taactggggg tggtggtgtg cacctgcagt cccagctact 76201 caggaggcag agaaggagga tttcttgagc cctgaaggtg gttgtgttac gtgcattcat 76261 gttaagagac caccaaacag gctttgtgtg agcaattaag ctttttaatc atgtgggtgc 76321 aggcagactg agtctgaaaa aagagtcagc aaagggagat agggatgggg cggttttata 76381 ggatttgtgt aggtagtgga aaattacagt taaagggggt tgtcctcttg cgggtacagg 76441 cgggggtcac aaggtgctca gtggggagct cctgagattt attgtccagg agaaggaatg 76501 tcacaaggtc aactgatcag ttagggtggg gcaggaacaa attacaatgg tggaatgtca 76561 tcagttaagg caggaactgg gtattttcac ttctttgtgg ttcttcagtt gcttcaggcc 76621 atctggatgt ataagcgcag gtcacagggg atatgatggc ttagctcggg ctcagaggcc 76681 tgacattcct gtcttcttat attaataaga aaaacaaaac aaaatagtga tgaaatgttg 76741 gggcagcgaa aatttttggg ggtggtatgg agagataatg ggtgatgttt ctcagggctg 76801 cttcaagcag gattaggggt gacacaggaa cctagagagt gagagagatt aaactgaaga 76861 aagattttgt ggtaaggggt gatattgtgg ggttgttaga aagagcaatt ctcatataga 76921 atgattggta atggcctgga tgcagttttg tatgaattga gaaactaaac ggaagacaca 76981 aggtctgaat aagagaagga gaaaaacagg cattaaagga ctaagaactg ggaggaccca 77041 ggacatccaa ttagagagtg cccaaggggg ttcagcataa ttatttgctt ggttggtgag 77101 tttttggtct ccatccttga gtttttttta tgttgtcata tgccaggcca gattgattta 77161 ggtaaaaaca acactcttca tttaaaaata tacagagttc tcctttctca gcagtgagta 77221 agtcaaggcc tcagcagttt tggaggaaag agaaatgcaa aggaagcaat tgtttgttaa 77281 gaaggattag aaatggctag gagagagtga gtgagattga tagtgtggtg gagatagctg 77341 aggagaggta gagggtggca taagaatggg aacgagaata agagtgagta taaaagtaaa 77401 gaatagaact tcatcagggt gaaagtattg gagggtgccc tgtcagcaaa gatcatctgt 77461 ccactccaag agggagtcaa gagtggcgga ttggggatag taccaggaga tatccactat 77521 gatggtttgg aggaaaagtg taaactggca gtgtaaacag gggcagggca tttatgagtc 77581 attgagaatg gtgaatagga gtatgactag acagaagata gtggagatga caaattttgg 77641 gggcacagtc caaatagtgg gggtgactgc gtagagctct gttgcaaaaa gtagggtaag 77701 gataaataga cttaatagaa tgaagagatg tattaggctc ataagggtta ttattgttct 77761 tcagaaatgc gagtgagttt aagggaagta ggggtgagta cttgcgactt ccagaaggaa 77821 gaggagagat caggctggct gtctgatggg cacagcttta ttctggaaca gtgaatccaa 77881 tggggagggt cgtgcagacg gatggcagtt ggggtgctat aaatgaccag gtagggtcca 77941 gtccatcaaa gctgtagagt gtgaggggtc agacttgaca aggactgatt gcccagctaa 78001 ggtatcttca catggctggg agtttggagg aggcaagaga agattagcag cctggcgaat 78061 ttcctgtcta gcctgctgga ggactggaag ataaaggcaa caggtcgtgg gcctggatcc 78121 tgtgtgagga ctctagcagc acagccttgt atttcagctg tgtgtaagga aaaaggatgg 78181 gacgagtcgg ggagtgctag tgtgggagct gtctccaggt cctttttgag agagtgaaag 78241 gaagaatggg gaaaagactt atggtctatg ggattagtta aattaccctt tgtgagctag 78301 taaagtggtt tgattaggat agcaaagccc ggtatccaaa gttggaaata tccaacaatg 78361 cctaagaagg aagggagttg ttgtttggtg gtgggggttg gggtctggga gattaactga 78421 acagagtctg caggaagggt atgtgtatgt tgatggagca ttataccaag ataggtaatg 78481 ctaggggaag aaatttgtgc ctcagagggc aatactttgt acccctttga gtaaagatgt 78541 tgaagaagca ggctagtgtc ctgctgggaa gattggtaag aggggctgca aagaagaaga 78601 tcatcaacat attgaataag gtgggaggta gatgggtgaa aagaaagcag atcatgagaa 78661 agggcctggc caaagtaatg tgggctgtcc ctgaagcctt ggggtagaaa aatccaggtg 78721 agttgttggg actggtgggt gtcagagtca gtccaagtaa ggcaaaaaga ggctgggagg 78781 agggatgcaa ggggatagta aagaaggcat ctttgaggtc gataacagaa tagagttgtg 78841 gaagggtgta ttgaagatag gagggtgtac gggtttggca ctataggatg gatgggaagg 78901 acgatttgat caacaagacg aagatcctga acaaacctgt aagacttgtc cggtttctgg 78961 acgggtagga taggggagtt gtaaggagaa tttgtaggct ttaagaggcc atgttgaaac 79021 aggcaggtga taacaggctt taaccctttt aaagcctgct gtgggatggg atattggcat 79081 tgagcggggt aagggtgatt acattttaat gggatgataa ggggtgcatg atcggttgcc 79141 aaggtaggag tagaggtttc ttatacttgt ggattaaggt ggggagatac aaggggagga 79201 tgtgaaacag gtcttgagtt gggtaaaagt gcagcaaaga gatgtggctg cagcccagga 79261 atactcaggg aagcagataa tttggttaaa atgtctcagc ctattaagga agctggacag 79321 gtggggataa ctaaaaaagt gcataaaaga atgttgtcca agttggcacc agagtggggg 79381 agttttaagc ggtttagaag cctcgccgac aatacccaca acagttatgg aggcaaggga 79441 aacaggccct tgaaaagaaa gtaatgtgga gtgggtagcc tccgtattga ttaagaaggg 79501 gacagactta ccctccactg taagagttac ccaaagcatc tgtgatggtc caggaggctt 79561 ctgaggtgat caggcagtgt cagtcttcag ctgctaagct gagaagatct gggaaggagt 79621 cagtcagaga gccttgggcc agagttccag gggctctggg agtggttgcc aggcaagttg 79681 aacagtctga tttccagtgg ggtctcgcac agatgggaca ttccttggcc cagtggccag 79741 atttccggca cttgaaggaa gatcctgggg gaggaggtcc tggagaaatg cctggcccct 79801 gcagtttagg tgttttgaag ttcttgtgtg ctggagatgt ggctggggtt tctcttacag 79861 cggaggcaag taattgcaac tcagaaatat gttgtcactt ggctgcctct tttctattat 79921 tgtacacctt aaggcgaggg taattaaatc ctgttgtggg gtttgagggc tggaatctaa 79981 tttttggagc tttttctaat gtcaggagca gattgggtaa taaaatgcat attgagaata 80041 agacggcctt ctggcacctc tgggtctaga gaggtaaagt gtctaagggt tgttgccaaa 80101 caggccatgg actcagctgg gttttcatat ttgatgaaaa agagcctaaa cgctaactga 80161 tttgggagag gtcagctaaa gaaaaaggag cattaacctt gactatgcct ttagctctag 80221 ccacctctct aagaggaaat tgttgggccg gtgggggagg gctagttgtg gaacgaaact 80281 gtaagccaga ccaggtgtga ggagagaagg tgaccaaagg tttatagggt aggggagcag EPI-109 869

80341 aggctgggga agaattggga cctggctagg cctagcgagg aacagcctgg ggaggagggg 80401 agaaatcaga tgggtccgta gaaaaggagg attcaaagga ctcagagctt ggggtggaga 80461 ctgaaggaac agacaggaga gaaagaggaa agatttggga tgagtcacat tgggagcaga 80521 gactagagag ggactgatgt gtaaagaatg cctggacgtc aggcacctca gaccatttgc 80581 ccattttacg acaaaaatta tctagatctt gtaggatgga taaatcgaaa gtgtcattct 80641 ctggccactt ggaactattg tcaagtttgt attggggcca agcagtatta cagaagaaaa 80701 taagatgttt aggtttttaa aagagtgcat aaaagaatgt tgtccaagtc catgcccttc 80761 ttaatcaata tgggagctac ccactccaca ttaccttctt ttcaagggcc tgtttccctt 80821 gcctccataa ctgttgtggg tattgatggc caggcttata agccccttaa aattacccca 80881 ctctggtgcc aacttggaga ggtcaggtgt tagtcaaagg tgttttaagt tttaagaaca 80941 caggctaagg gagaagaagg gggaatgaag cgtggaaggt tgcccatagt gaaagaggta 81001 agtttaaaga gaaaggtaga gacatggaga aggggggagg tgagcagccc tgggctgtca 81061 tgtgggttag cagccaaagc tggtgtccca gcaattgact taccaccaag ggaatgtggg 81121 tgaatgacca aggcaggcat ccccccggtg atcagacacc aaatggaatg tgggtgaaag 81181 atcaaggtag gtgtccccat gatgatcaga caccaaagga aggctgtctt cccaaatcca 81241 tgatccatgt tggagttttt gagttcatgg ataaaatgtg tctcctttgt ctctactaga 81301 gaggaaaaag aactggaatt tgaaggacag ggagattgaa gggtagggag agaggctgaa 81361 gaagagagtg aggagaccgc ttacccggtt tgaaattggt gagatgttcc ttgggctggt 81421 ctgaggacct gaggtcgtag gtggatcttc tcatggagtg agggtgagga gaggggacca 81481 atctcccgaa ggagtcaccc tgtccggggt cttcggcacc aaatgttatg cgcatccata 81541 tgaagagacc accaaacagg ctttgtgtga gcaataaagc tttttaatca tgtgggtgca 81601 ggcagactga gtctgaaaaa ggagtcagca atgggagtta gggttggggt ggttctatag 81661 gatttgggta ggtaatggaa aattacagtt aaagggggtt gtcctcttgc aggcaagggc 81721 aggggtcaca aggtgctcgg tggggagttc ctgagactca ctgtccagaa ggaatgtcac 81781 aaggtcaatt gatcagttgg ggtggggcag gaacaaatta caatggtgga atgtcatcag 81841 ttaaggcagg agcggcctat tttcacttct tttgtggttc ttcagttgct tcaggcaatc 81901 tggatgtata tgtgcaggtc acagaggata tgatggctta gcttggactc agaggcctga 81961 caggttgctg cagtgagcca agatcacact actgcactcc tgcctgggca acagagccac 82021 aaaaaaaaaa aaaaagaaaa gaaaagaaaa aaaaagaaga agaaaaaaaa attttttttc 82081 caccaagaat ttagtaaaaa attataggga aaagtgtcac taattcaagg gaattgcact 82141 gaaaattatt cattcattca acagatattt attgagaagc aagtatgctg gtgctagggt 82201 tacaacagcg cacaaattct tgtattcaag gaatgaggta agagtatgca gataggagcc 82261 agagaggtca agaggcaatt gcaacataga gtgacacgtg ctccagaaca cataggaggg 82321 cttccaggcc ccatgctggg ctatcagagc tggcttcctg caggtggtgt ggctcagcta 82381 aaacctgaga accaagaatg agccttctga tatctcaggg ttaaatcggc acaaatgaaa 82441 ccattttata accaaacaac attttccctc ctgaactgca ctttttctag aacccattta 82501 atccttccta acatgttcaa tccagccccg tgatttttca gtcaaatgca agatgcgtag 82561 gattcctttt ctgttcagtg ctccccagcc aatctttttc ccttctccca ccccacagtt 82621 actaattcca gcgtttcagt tctcagcaga ggatgacagt tccaccagga gacatcagtg 82681 ttatctggag acattttagt tgtcccagct gagggcacag tgctgctggc atctagtggg 82741 tgaaggtcag gaatgcacct caacatcctg gaacactcag gacaatcccc agcaacaaaa 82801 acctacccat ccagaacatc aacagggctg tggctgagga gccctgctct agtgcttcct 82861 ccttactgta tcctcatcaa ggagggctct ggggcatgtc aggggctgct acaggctcct 82921 ggcagatttc ggcgacttac tccagacttg tggaacattc aggattctta gcatggccac 82981 aggagagtca ggctgtccac aagcactctc tctttcttca cccactcatt cctgtcactc 83041 taccatttcc actgccttcc caaatgccca tcgtgagtcc caccaggggc cagaacacca 83101 ctctctcaag cctccccagt ggcgcgtgca cacctggaga acatgtctca catcccccag 83161 ccagcgagac gtcctgagat tccagcactt ctcagtgtct ttcccagctt gtttgtatct 83221 ggaatggggt ggggtctctc acacaggaga aattacaagg aaaagtgtac gtgacaggaa 83281 tggaggaatt tctgtggaaa cggtgtgtga gaaaatgtag gaagaaagaa acttcaggaa 83341 atggtaagtg gcatcttgag agcagaaagt gagaagggag cagaaagaaa tggggctgga 83401 acctgggaag gagaggacag gtggggatgg ccttgcacac cgtgggcact gaggagtgtg 83461 ggcccatggc atgggtggag aggagtttca agatagggag tagattccta ttttgaactt 83521 cggattgccc ctggcgatgt ggagactgta ttggaagaag gcaagaatgg aggagagccc 83581 ctaggtggag gtttggcaat gctctctcca gaatatagca gaggcctctt ccaaggtagg 83641 aaagccctga ctggagagaa gttaatggct ctgagggctc aagggaggac ttggattatc 83701 aggactttta gggaggcata tgatcaaggc ttgggtcttg gcccattgaa atggggagca 83761 ctggttttag gatgtgggtc aattagtttg gttttcagga caggctgagt tggatatcct 83821 gggggacctc caggtggcag tgtcagggga agctggatgt gctgacactg aactcagcag 83881 agtgactgag tagagatcga catctggggt cacaggcagt ggatgccgta ggggtggact 83941 caatagctca agcagaaccc ggaggaatgc aggcagcaaa gggagcccta aagaacagtg 84001 aggagatgtg ccaagaaaga gccaaatccg ggggattggc tgtgggagag agggctgtgg 84061 gagtaagagg aagtgtcagc aacgtcaaat gttgcagaga catagagtaa ggtaagagtg 84121 gaaaaaacat ccatggaacc ctgtgatgca atcggaatgc agaaagactt tgtaactcct 84181 gcctggtctc ctcctctgcc cactcatggc aaaggaatac aaagtaatgt tccctccttc 84241 cgcctagaaa agcacaactt ctgcccccaa gccctgggct ctcctgagag gacaggacca 84301 gcctctgaag ttgaaggtcc tggttctgcc cccaagccct gggctctcct gagaggacag 84361 gaccagcctc tgaagttgaa ggtcctggtt taccagatag ggaaggggcc ctttccaaga 84421 ccctttccag aaggtgtggc tgagatggga accgtggact ctgtgcagat gtaggagctg 84481 gctccagtca agtgctagga ggttgtgggt cctgggaagg aagaggctct ggagcctctg 84541 tggagactct gggactgtcc ttgggggaga cgtgagcagg aagaagcagg gccttcacag 84601 tccccagctt aggggcctca ccacccagac tgaagaccag gaccaaaccc tttcctgcac 84661 agttacaatg tgtcatttaa ttttactaaa gggaatattt tttaaatgag gatgctactt 84721 tgtgtattaa tttttacctc tattcataaa agaaacgttt cttatctatt taagatgatt 84781 catatcagac cagtgtctgc ccaactcgac tgaccctgtg aaaactgggc acttcacact EPI-109 870

84841 ccaatgatga tggatgagtc cccagcagca tagtttaagg gagtgagtgg gcagtgtggc 84901 ctcctgtgca cgtgacttcc tccttcagtg tgcccacatg tgggttccac ggtcttgtga 84961 cattgtggct ttagaaattt ctgtttccat tttctatcat tcagagtaaa tgaaatttgc 85021 aggaaattca gaaccttcca cctgtacagt ggatactgtg agactctgcc cagatgccct 85081 cttcaagcca atgcatctct ccatgctccc actcccatag atgggaacag aggtgctgga 85141 actcagatct actccccttt ctgggaactg gagctgcctg cccaggcaat gcccccttcc 85201 cagggatggc tgagccaatg actggctaat gttggattgc agaggcctag cgccctcccc 85261 tcaattccta attccttgta ggaataactg aggcctcctc tgtgaccacg tgggcagctt 85321 ctccctctgc ctggtcctgt cttgttctct cctttccaat tgtgtctcct ggaagccctc 85381 cccacaagtc tgctgcatac aactctcctt ctcagagagc ctgagccctg gattcccagg 85441 aatccagcct aaaatagtct ggcatttggt ttcaattttc tctttcacta agactcagtc 85501 acaggtgcta ataaataata aaatgtcacc accttgaatt ctatcactct ctcttttctt 85561 gccccatctc tgacaagtag gtggtccctc aagaacctga aaagcagaca ttaggaggaa 85621 aggaggagtg ggggcaagag gcccacacct cacctggccg gctcccatcc atgcgccctt 85681 gactgaggta acacctaccc tgggaatcct tcccctgcct ctcgtgagcc aggccgggtg 85741 ctcttgggac agctcccact gctcctgtgt gctcccccag cttggcacat gactccctga 85801 attatagtca gttccgtacc tgaatctccc tctagaatgc cagtgccacg aggacagagg 85861 acggttccac tttgttcact attttctccc cagggtctgg caaagttcct gggacttggg 85921 agaggtgtcc ttcaggagct tggcagaagc caaacggcac acttaagtag ggcaactgag 85981 gtgagtttaa tgaaggattc tatacaaaaa tttggacaag gtatagggag gccacaatac 86041 acagtgcagt gcctggtgcc agtgagagca gggcactatt cccactgcaa ggccagacag 86101 ggcaagggga gggagctgcc tgacaagagc tgcccttacg tcaagggaca catcagccca 86161 ctagacccca tcaggaggga gccagggcct gactcccctg accttgctct ccaatcttct 86221 gcctaaaatt ccccatcagc caaacacaac tgaaaactga aagacagggg agcctgctgt 86281 taataaggtg agcttccccc agaataaagc tgggtagaga gtggagaatg gatatggaag 86341 ggcaaaagga agatttataa gacagtgggc actaaatatc tatgagatga ataaaggaac 86401 cacattttac aacaaacggt cattgaaacg ctactcaatg gaaagagatc atttcggtca 86461 ctgtctggtg cagacaaatc aaagcccaca tgcatcaaaa aggccatgtc cgtgtaactc 86521 cgacacgggg cagacagcaa ggctgaagcc tatggggtat gtggagccgg aactgagaga 86581 tcctgatgta aatctagcac ttgggaaaag ggggactaga agaaattcac ccacaggcag 86641 aggaaaacac aaacacttat ctatttttgc ctaggcttta agtggtatgg gaaaaatctc 86701 tgagactaca aatcctgtgc ttcatgcaca ggtttataat accctcaaaa tggaagaccc 86761 caaaaccagg cgcggaaaat tcatatcagg ccattgatgc cctcaatgtt cccggctgaa 86821 acaaactcaa aactcctctg gaaaggagtg ctcccacttc aagccatgaa aagctactgc 86881 agagaaaata atccccagtc aagacacact cacattgaaa ctgcaaggca cacaaggaaa 86941 tggatcacct tgagtgatag ctggcagagc taataaacct ctgtatacct ctaagaagct 87001 ccacgcacta gtataaccct taaagatttg atgaaatcat tactttatta aaattgtttt 87061 tataaaaaat caaaatccaa aaaaagcaac aaattttata ccagagccaa ttcggtatat 87121 acaagggtgt cttactcttt tggaatttgt cttattgtcc taactcagca cattgtcctg 87181 gtctatgaaa agtcctagaa acccttctac cctctgtaat gtaggagctt taactcaata 87241 gggtttttta aattcttttt tcttgtcttt ttttcttttt taattttttc cattttttca 87301 agtcaaactg aagaaatatt tttcttttct ttctaggaat gcatattcac cccccaaggc 87361 cacttgtctc ctgattggag agtattagac aattctcagg atttctttat tttccttctt 87421 tattccatag gattgggaaa cccagtagga ttgggtttag gcatatctct aaagcaccat 87481 gtttcaacgt tttgatgtaa gattgtgccc tatttcttgt tcagttgctg ccagcagatg 87541 ttatagtttt aaaactagtt tttggtcatt gagatattag aggagggaag agtctgctat 87601 cctgctttac tcatcttcat ctacactaca ctgtcatctt cactgcaaag tcctgtatta 87661 atgtttttag attctataac attttaacag gtgtcaaaaa atcttaagca ccacttcagc 87721 ttgggaatct ctaaatgtaa tggtgtttgt gggctggact gatgtctgcg tcttgttgtt 87781 gttattgtct gtagtaatgg agagccggga gatcctggac acttcctgtt catgggcact 87841 tgatgcatta gctgccccag cagctgatta catttaaaca aggatgtgtg ggtgaaccca 87901 gggagaccaa tctcagtgga atggtggggg cagaagccag gctgcagggt gtagagtagg 87961 gaatgagcag tgatgaagta gaaacagagt ttggacaact agtgaaactg cctggaagag 88021 ggggagaaga gacagtaaat ggtctgacca atgtttgagg tcaaagtggg tttgtaatct 88081 ttatttaagg gacagatctg agcatttaaa aattctgaat aatctaatag agaggaaaaa 88141 gttgggactc aaagaaaatg tgggaaaaaa tgatgaaggt taaacggaat gagatccaga 88201 gtgcaggggg agagattagc ctttggtgtt agaggagcaa ctctgtccat ggagagagga 88261 aaaatgtaga cataccacag ttgcatttga agttggggcc tgaggagttg aggagttctg 88321 agaaaagcag aagatgagat catttcctga gagtaaatgg gagtcattag aacgggggtg 88381 aagagactgg aagctttagg tagcttgaaa tagttgatgg aaaaattgga taaagtgaca 88441 atttgtcaca ctcagaacag ctatcaggga atctagaaga atctctggaa gctagttgaa 88501 gatcttaaat taccaatgta tcttgtccac atagctaagc ggttttactt atttttattt 88561 ttttgaaaca gggtctcact ctgtcacaca ggctggagtg tagtagtagt agcacaatca 88621 cagctcaatg caatctctgc ctcccgggct caagcaatcc tcccacccca gcctcccggg 88681 cctgggacta cagacacaca ccaccactcc cagctatatt ttgtacattt gtagagacag 88741 ggtctcgcca tgttgcccaa gctggtcttg aactcctggg ctcaagtaat ctgcccacct 88801 cggcctccca aagtgctggg attacaagct tgagcccggc tgctaagtgg ttttaaacag 88861 ctgttctcgg aaacacacac tcaaagaaaa aatgtagagg ataatttatc taaggctggg 88921 gcttcaagag aggtcagggt gttgacaaga gaatgactaa gtggcagact actggatctc 88981 agctagataa agagggatgt gatcgtggga ggggctgata gtcagaggct ggaaggcttg 89041 atgaacaaca catattacac aaagaataaa tggagtgaga gaaaccaaag gagtaaaagt 89101 tgtcatcaga aaagtgagaa attttattgt gagaattcag tggtaaatca atgttaacaa 89161 acctcagctg ggcactagtg gagtgaaacc gaaggccagg gagttgagtt aatgagctga 89221 gacttgggca ccagatgggg gtccacatgg acaactaagc caccaggatg atgtgggaaa 89281 ctggggtgaa tagaagcccc ttatccatgt gcacaagtct tgaataaaat aggggcaacc EPI-109 871

89341 aggcagtcag tggatgatag cagtgaggtg gagcagagag caatgtagtt ggagaagtgg 89401 agcccacagc agtctccttt atatctagaa gggaattaat agccaaaaaa tggcaccgag 89461 gccaaggatg tcaccttctg actcccaaat ctgagacaga tgtgagaggg aaggagtatc 89521 ctcaagggac aggagatggt gcgaatgttt ttggcataaa tcaaagatgt cagggaaatt 89581 gtcagaattc aggttccaga gacacagagg aaaagcgtgg gagaaagtgg aatattggga 89641 ggtgagatta gggcagagga agcacaaatc aaagaacgag gaatagaaaa agtcatatga 89701 gctgaggagt tggccaaaca tgacagaatg ggaatatgat ggaattaagt ggctttatgt 89761 gttccaaaag gattggtcca cgcaggccac aggaaaatgg gaggtaagaa gaaagggatc 89821 gaaatgctgc aaagtgtatt acttcatggt aagcaaagga ctcaagactc tagaaaatga 89881 tgcccttcct tccaagacta tgttagtcca aatctttcaa gatacagaac ccaaggtggg 89941 gtctggcata caagaagtat aatagaggaa atgtctgtga catttgcagg actgcaaagg 90001 gagccaggag aagctgggaa agccatgaga tcacaagcag gtctgactcc aagtgaagga 90061 gatggggaat gacgcaaggt ttggctgaag catgtgccaa aggcacccat cagaggagtc 90121 cctctccaag ggatgggcct atcatagtgt ccctaatagt gtcatggagt gggagcagcc 90181 cacggagggc acagccttgg catgaacgca gacatgggtc tcagagtgca gcagctgggc 90241 ccctcagtca attaggctcc ctcagagctg gggcaggagg tgcactagac cacacagtaa 90301 tatttattta ttattaattt aattaataat attaatttat taatttaatt aataatatat 90361 ttatttattt attattacta gaccacacag tagtatttgt atgtctaagg aagcatttct 90421 cagaatatac tcactgaact tttagcctat aagtacctgt atgaaaattt taaaaggggt 90481 ttcatgatca aaacattttg ggaaacactc catacccttt cttcctcatg aaggatcata 90541 atgcctatta gtatatgaag ggctctgaga agtcctgtag taaagaaact tgctttagtt 90601 ttttagtcca gcaatttttc aaacttaaat gagcaatagc ctcccatcct tttttttaca 90661 ctttttagca tactgcggaa taaactcaac atgcattgag aaagactgct ttagggaata 90721 gtcaacacta tttcactccc agtaagtaca tataaaatct gtatttccag ggtggattat 90781 caacacagct gtattttag.a aatattatct gccctcccag gtatcacagc tactaattat 90841 tgggtactga ggtggaattt tagggatcag ccaattatgg gaaagaaaat ctgggggcag 90901 gataagatgg tctccgaagc cttaaaatta tatgccatta tttacctctt tgatctacta 90961 ctcaatatca aacaactaat tcagaagaaa attgattgtt ttctaaaagt agtttttcta 91021 catttcccat taagaagcag tggtatttaa aacttataat ggctattatg tgagattatc 91081 actatcatag tttttctcta tacaaatttt ctgtaacatt ttatttgcta ataaaaatta 91141 gatagatgga ttgactaatt gataatctaa gaaagattat atttgaagaa gccatagtaa 91201 gggacagatt aaattatcat cagtctaaac attctaatac ctatttctct ttttttgaaa 91261 ttttccaaat ttgttattat gcatttaaac aataattttt tgaactttta ttttaggttc 91321 tggggtacat gtgaaagctt gttacatagg taaccttttg tcatgagggt ttgttgtaca 91381 aattatttca tcactcagct atcaagccca gtactcaata ggtatctttt ctgctcctct 91441 ccctcctccc accctccagt ctcaagtaga cctcggtgtc tgttgttccc ttctttgagt 91501 tcatgtgttc tcatcattta gctcccactt ataagtgaga atacaaggta tttggttttc 91561 tgttcctgtg ttagtttgct aagggtaata gcctccagct ccattcgtgt ttccacaaaa 91621 aaacatgatc tcgttctttt catggctgca tagtattcca tggtgtatat gtaccacact 91681 ttctttatct aatctgtcat tgatgggcat ttaggtttat tccatgtctt tgctactgtg 91741 aatagtgctg caatgaacat tcacatgcgt gtgtcttcat ggtagaatga tttatattcc 91801 tctgggtgta tacccagtaa tgggatttct gtttttagct ctttgatcta atacctattt 91861 ctcaagatca agttagatct ctaaaaaagg catcatccta gcatttcccc atcccttccc 91921 tgaactaaat ttaatgttgt gtgtatcaat cagcatacag tcaagacaga aaccacacat 91981 gaacattaaa tataatgagt tattaactta taaaagggta tgaactacta aagggggtaa 92041 ggagaatgct gaagaatgca ggaatggcag atgtagagag cagccataac ctctaagcta 92101 aggcacagca gccaaggaag gggcgaactc aaaaaatgcc ctccctcccc agctgatcca 92161 cccttgttgg agggggtgtg gctgcaaccc aatggatgcc caagaagttt gcagagttgt 92221 ggcaggttgg ggctgctgag caggaaactg cccgaagggg taccagtgag attcccaaga 92281 atgtgggcat gcctctggcg aggaagacgc tcttggagtg ccagcaaaat ttactaggaa 92341 gctacccagt agggtgccag caaaagtcag caggaagcca ctgtcgtggt gtcggcaaaa 92401 ttcactgagg agtgggcact gcagggtctc cacccagcac tggcaaatca gccaaaagaa 92461 caaaaacaaa ataaaaacaa atcccagaac cagaaagaaa aaactctgcc tcttactgcg 92521 accctcttat gccttctaca gcaactggca aaggagaaat gtttatgggg tccagctcta 92581 gactcacaaa gcagaacaca gaagagtgaa tgaagagctg aaaggcgata aatcagtaac 92641 tggagcctca catcctttgc cttttttatt gagggtcaat atattaagaa gaatatgtct 92701 gcgtcttcgg taaaattatt gctaaggtta tcacccagtg tgtgttttca acctccctga 92761 tataagaact tagtgacaag aaagaatgag acaatgatca tgaactattg gacccaacca 92821 tttgtggctt tagtgcccat cttctcagca aggctttctc tctctctctc tctctctctc 92881 tctctctctc tttttttttt tttttttttt ttttaagatg gagtctcact ctgtcaccca 92941 ggccggagtg cagtggcaca atcttggctc acggcaacct ccacctcctg ggttcgagtg 93001 attctcctgc ttcagcctcc cgagtagctg ggattacggg cacccatcgc cacccctcct 93061 ggctaatttt tgtattttta gtagagatga agttttgcca tgtcggccag gctgttctca 93121 aactcctgac ctcaagtgat ccacccacct cagcctccca aagtgctggg attacaggca 93181 tgagccacca cagccagctc tcagcaaggc tttttctgac tacactattt aaaatgtgat 93241 ccctgagcca ccttggcctc tcttgctgtc cttccctgct tcgccttctc catagcactt 93301 ctctcctact aatctacaat ttacttgagc tctgtgaagg tcaggatttt tgcctatttt 93361 gtccattggt gcatccccag cacctggaac agagctaggc acaggctagg cactctagaa 93421 atacttgctg aataattgaa ttaagtaaat gagtgatcta cacgtagtgg ggaatgagag 93481 tatacagtga tagttccttc gactaaaact ggggtcaaat tatagtgata aagaggaact 93541 cagaccttca gaggtaagct ttgtggacca cttgccaagg ctgcagaatg tgatgtcgtt 93601 tcacaaacaa ggaggcccta ttatggcttc agatatgaga ataataaaga gaactttcct 93661 ttcgcctcaa ctgcagcctt ctaaactctt ccttccttcc tatgtagaag tttcaaggac 93721 ctcatggcct gagtgtggat aggcagaatg ctgggaatca ggcaaaaata aaataatact 93781 gaaagtgaag gtcatgctaa tattagtaag ccagggtgat cctgaattta caaaacattt EPI-109 872

93841 ttctttggga aatttcacac ctcacatgat tctgtgtttt tacttgggaa atttcacatc

93901 tcacatgact ctgtgacatg cggtacatga ggtgcctgac tgctgttttt gtcctctact

93961 aatgaggaag agtgtgcgta ctcccagcgt tttgcaagtt tcaaagtctg acttgacttt

94021 ccttcctttt cctggaactg atccatgagt atcgagagta aagctgcccg cacctactca

94081 ttcaagatcc tgagtgtcct gcccagctgc aggaggtgga gagacccagg aggaggggcc

94141 actgctgatc ccaggctgta gggggtggga agagtgtccc agggcaccat gacccccact

94201 cactcactca caggagaccc acacaagaga ggagagggca cttacagctt aggttcccac

94261 cagcaccaac tcctctgcca tcaaacatca ttgtgtttct ctttctgcct tgtctgtcgg

94321 cacacgtgga gttaaattta atgctcaatc acatatttgt ctgggctctt tctgtgttta

94381 tttttctctt aatagttctc tctcctccct tcctctcccc gcccctcctc ctccttcttc

94441 tttttttttt ccagagacag tgtctcgctc tgccacccag gccagagtgc agagtggcat

94501 gatcatggct caccgcagcc tccaactcct gggctcacgt gaacatccca ccttggcctc

94561 tggaatgtct gggattacag gcacttgcca ctgcatctgg ctaattttta tattgtttat

94621 agatccggga tctcactatg ttgcccaggc tggcctcaaa ctcctgggct caagcgaccc g4681 tcccacctca tacttctgag tagctggggc tgtaggaatg cgcctcagtg ccaggctagt

94741 ttcttaattt tctatttcta ttttgacagg tacaaatttt gtattcaatc ctacctcaga

94801 cacatctttg gtgggaaaag gatgtcattt aatcaatata taaattctaa gcaaataggt

94861 ctgatcccca aattaggtta gtcacagctg ctgagtcgtt gacccaagag aagctcatct

94921 agattttttc attattttca agttcctctt ctcggttcgt ccttcttcca gaccatgccc

94981 tccccgtccc actctcttcc cacagcctcc cctccccaca gcctcctccc accattccaa

95041 atctgggctg ttctctcaat ttccttctct ctggactcaa acctacccta gcccccagcc

95101 tcagtttggg gttaaacttg tcctcctcac attctctccc acccaacttg atgtcgcctc

95161 tgtgtcatca ccacgggatt ttcctcctct gggttctcct tttccgagtg gggtcagctc

95221 ccccatgagt cacagcacca atcacttctg gctgcttgca aacccctttg ctttcctcag

95281 tgttgacacc cagggcagcc ctatgctcac tgccgctgag accccacctc tgcccctggc

95341 cttttcccag ctgacatcac cctgtggctt ccattttcct aaaattctct tttgaggcct

95401 cagtcttaac caaagcacac agtgcccctc aaaaatgaca ataaaaaccc aaacacaccg

95461 tgactgtcat ggcaggttcc tggtccccgt attgaatcag cgggtgggtt tctgcgaaca

95521 ctggtgagag gccgcattag agggtcagga ccctcaggtc tggactcgtg gtcaccacat

95581 accttcctcc ctgctgacag tagctggtac ctgttaccta ctcagagtgt cacatgccac

95641 aagccagagc gtcttggcag ttctcagcac cttgacatca cttccttgct accactcaga

95701 gcggcagtga cacagttccc ttatctcaga aggccagaag acggctgtca aaggtcacag

95761 ggaaatcaaa ggcggggtac agggccagag ggaggaggaa acaacttccc ggttgctttc

95821 agacgcttca gagatcctct ggaggcctgg gggagctttt gagtacttta tttcagttgg

95881 tccctgagct cggtgagtgg ggcgggtaga gccaccaggg gaatcaacag tggtttctcg

95941 tgcccctcag ggtcaggagc agtctgatca aaaggagggc atccactgtc cggggccatt

96001 cccacagctc ccggatgctg ggtctggagg ctgcgccctt cccctgcagg agctcagccc

96061 agtggtaagt catctgtgtg tcatctatgt atttaacccc ttatggccat gttgatgctg

96121 agcatggttt cacttttgca aacatttatt tatacccttc gagagaaaaa cgtctcagct

96181 gtcacaggaa gctgcttcgg ggggtgagca aactttttaa aatgcagaaa ttatgatcta

96241 cacccgtttc ttaaaagtaa gccatcgtac ttggttctct ttaattatat attttcttac

96301 atattgtgtt catgtaggca agtcctgttt ctgctaaaag aaggtaagtt ctaccaaggc

96361 ggtgtcatgc cagctttatt tcccgtggca cctggcacac tgctaagcac ttacatgctt

96421 aacaactaga ttgggaatgg tgctgctctg gggaagtggg cacacgttaa agaaatgttt

96481 atttcagtct tctgaaatag ggaattactc tggctaaaat gtagctccag aaagggaaag

96541 tggggctgta tgaatccagg tccagtttgt tgtttcctcc aggataaggc agctgtcgga

96601 ggggaaaatc atctcccatt tctccacagg gcagtctgaa gatggccaat tacacgctgg

96661 caccagagga tgaatatgat gtcctcatag aaggtgaact ggagagcgat gaggcagagc

96721 aatgtgacaa gtatgacgcc caggcactct cagcccagct ggtgccatca ctctgctctg

96781 ctgtgtttgt gatcggtgtc ctggacaatc tcctggttgt gcttatcctg gtaaaatata

96841 aaggactcaa acgcgtggaa aatatctatc ttctaaactt ggcagtttct aacttgtgtt

96901 tcttgcttac cctgcccttc tgggctcatg ctgggggcga tcccatgtgt aaaattctca

96961 ttggactgta cttcgtgggc ctgtacagtg agacattttt caattgcctt ctgactgtgc

97021 aaaggtacct agtgtttttg cacaagggca actttttctc agccaggagg agggtgccct

97081 gtggcatcat tacaagtgtc ctggcatggg taacagccat tctggccact ttgcctgaat

97141 acgtggttta taaacctcag atggaagacc agaaatacaa gtgtgcattt agcagaactc

97201 ccttcctgcc agctgatgag acattctgga agcattttct gactttaaaa atgaacattt

97261 cggttcttgt cctcccccta tttattttta catttctcta tgtgcaaatg agaaaaacac

97321 taaggttcag ggagcagagg tatagccttt tcaagcttgt ttttgccata atggtagtct

97381 tccttctgat gtgggcgccc tacaatattg catttttcct gtccactttc aaagaacact

97441 tctccctgag tgactgcaag agcagctaca atctggacaa aagtgttcac atcactaaac

97501 tcatcgccac cacccactgc tgcatcaacc ctctcctgta tgcgtttctt gatgggacat

97561 ttagcaaata cctctgccgc tgtttccatc tgcgtagtaa caccccactt caacccaggg

97621 ggcagtctgc acaaggcaca tcgagggaag aacctgacca ttccaccgaa gtgtaaacta

97681 gcatccacca aatgcaagaa gaataaacat ggattttcat ctttctgcat tatttcatgt

97741^' aaattttcta cacatttgta tacaaaatcg gatacaggaa gaaaagggag aggtgagcta

97801 acatttgcta agcactgaat ttgtctcagg caccgtgcaa ggctctttac aaacgtgagc

97861 tccttcgcct cctaccactt gtccatagtg tggataggac tagtctcatt tctctgagaa

97921 gaaaactaag gcgcggaaat ttgtctaaga tcacataact aggaagtggc agaactgatt

97981 ctccagccct ggtagcattt gctcagagcc tacgcttggt ccagaacatc aaactccaaa

98041 ccctggggac aaacgacatg aaataaatgt attttaaaac atctatttaa tgtattttaa

98101 aataatttgt aagttgattt taaaaccaat ttaactacat tccaaattat agacagccca

98161 tttatatggg agtaactttt caggctcatt gcctcgccgg tgatgaaaag aactagctag

98221 ctggaagctg tgggaaaaag aggtaaggta acttgttctg tcgaagttct ctaaattctc

98281 ttgcttactt gccacacccc taggccccca gcttccccta acccaaggtt tctggtattt EPI-109 873

98341 tctcgtactt tatcaagact atggaatctt aggagactta acaaaagcaa atgagaaatt 98401 atgtttagaa atgtctaaca aaatgaattc tttgtccttt taagtataac acatacctca 98461 ggcctcacca gcacataact acaaaaggtt gtcccacttc ctttctgtgg ctgagttagt 98521 agaacacagg ctcccacctg ccacatcagc agaaggtcac ctcaacatgt gagctacctc 98581 cccggagacc ccccagatcc gtaaggatga tgcatccttg atcctaaaaa cattttcctg 98641 ttcctggtgt tcagaattgg actccacact cactggtctc tttataatct tgcttctggc 98701 cctttgaggc ctcaaagcta ccagggcctt gctgccaggg gacaatcacc gctcccggct 98761 gagtcctgca gacatagggc ctgggctggc tgcctcctcc tgctggccca gcatcttgct 98821 tgcactaaag agagctggag gcttggcact gatgcttgct aaaaacctac ccaggccgcc 98881 cactgctgcc gcactgcagg gcaccagccc acactcctcc cctcctggca tcaggcacac 98941 gttcacggca ctaaacctta caggaaagca gtggaaccct gtctttcctt cacaggaggc

9gooι actttccttc ctaggcaaaa acgatgatac ccatgggcac agcatctcac atagggacac

99061 atagagatgt ctgactcatt aaaacccaag tctctggcca attaaaaggg gtccttaatg

99121 tcctactcaa cagtggtgga aggaaatttg ctctatattg atgaaatgag gtggagaaaa

99181 tctgattttc caaacatgag aattctccat atgccacccc ataaccaaag accccttatt

99241 tgtgttagat gaaacattca aagagcctat taggatagcg gatgagaccc ccaagggaca

99301 tgcttataca acaataactg gctccaaacc acactccatg gcagtggctc tcaaatgcca

9 361 gctcacatca caagccctgt gctaaaacac agagttctgg gccccatccc ggagtttgtg

99421 gttcaggagg tctggagtgt gacctcagaa tatgcatttc taacaaattc cccaggggat

99481 gcagatactg ctgacccaag gccctccttc tgagaaccac tgttccaggg agaagaaact

99541 cagctaagta agggtttggc tttgtgctga agacaatgtg gaatttagag ttggggtgaa

9 601 ttattcagga aagtagagag gtttggagat gtgagggtgg gaagcgcagt ggagggaggc

99661 agagaggaaa tatgaagcag cgtcagttgg agagaaatta ggaagaggaa taaaatgata

99721 tatgccaggg atttcagttt tgctgagccc atgatgacag actcttctct ggcaccttat

99781 gccactcatt gagggcttgt agctggctct gctctttcag agtcataata gggctatggg

99841 tctgacctca aggtgagctg gaatgggcac aagtaataga taaaactgca agaagtcact

99901 caagggtcct tcctagaaca aaggatccct acattccaaa ggcgaatgcc ggtcactatc

99961 ataaaagaaa agaaagaaag aaactgatgg tgacatttta aatggcaatt tttctagctt

100021 ctaaaaggtt gtggagcaac tggaactttc ataccctgct ggtgggaatg taaaatggta

100081 taatcacttt ggaaaaattg gcagtgtcac caaaagcaaa gcctatacct actatccatt

100141 tcactcctca gtatttaccc aagagaaatg agcatgtatg tccatacaaa gatttggacc

100201 caaatgttca tgacagcctt atttatatag cctcaaacta gaaaaagtct gtctatcaac

100261 aggtgaatgg ataaacaaat actggcctgt gtatctaatg gaatactgct catccacaaa

100321 aagaaacgag ctattgatac acacaggagc atgcacgaaa tctcaaaatg ctgaatgaag

100381 gaggccagat tttaatttta tttttaatta tttatttatt tatttatttt tgagacagag

100441 tctcgctctg tcacccagcc tggaatgcaa tggtgtgatc ttggctgact gcaacctctg

100501 cctcctgagt tcaagcaatt ctcatgcctc agcctcccaa gtagctgtga ctacagtcat

100561 gcacaagagc aactgactaa tttttgtaat tttagtagag acggggtttt gccatgttgg

100621 ccagctgctc tcacactcct gacctcaggt gatccacctg cctcggcctc ctaaagtgct

100681 gggattacag gcatgagtca ccgtgcccag ccggaagcca gatatttttt aaaagtactt

100741 attttgtgat tctatttata taaaattcta gaaaatgcaa acaaatccat agcgacagca

100801 aatcagtggt tgctggagat gttggagggg agaggagagg aatagattgc aaaggggaac

100861 aaggaaattc ggggggacag tggatatgtc tgctattttg actgtggtga tggtttcatt

100921 ggtatataca tatgtcaaaa acgtaacaag ttgtatacgt gatttattat gtgttgacta loogsi tacctcaaaa aggctatttt ttaaaatccc cctcaggctc caggcactcc attacgttgg

101041 tgtgacttgt cttggaaata tactttgagc atttgccgga ggagatccag tgcctgggcc 101101 tctgtttctt ctcccaagta gaattggcag ctaaaacggg atgcccatgg gcacaacttg 101161 tcacccccat caccgaacag ggagcagaag gaggctgctg ggggtgcccc cacagggagc 101221 acagtctcat cgggaatgac ctgccatggc aaataaaatc accagggcaa gtcaagggag 101281 agaccaggga agagagtgat ccagtctata ttaaaaaagg atgagaaagg ttgaagaaaa 101341 agagaagaag ggacagaaat tctcttcaca catttgcaga agtaggtccg gactctccat 101401 ccacttctcc tcctccgata ggtaggacag gaatctcaga ggaaatggca tcatcttccc 101461 atgtttacag acacagcaat gaactcaaag aacaatctta tcaggatttt ccaaatgaaa 101521 acatggagca tatagagaat aaagatccat aaactcgtat ggtggctgag actgaaatgg 101581 ttaatgaaaa gcaaaagtgt gtgctgaatg acaccagcca caatggcctg aacacttaag 101641 tagtgtaata tacttggaac attgacagct aacaaggtct tcctcccatg tcagaccaag 101701 aacacagttt cctaaagata aaaatagcac atgcttttcc acttttccat aagtgactgc 101761 attagaaaac taacaaacca tgaaaagcaa aatatggcta gtctcttcaa gaaaaactgg 101821 tgtttctatt ttgtctgtaa attactttct aatacaaaaa acaattcctg ttacattgag 101881 gtaattctaa ctagggacat atgagagaga gattgaaatc tcatgagctg tctccttttc 101941 atctcaattc tgtgtactcg tgggtacaaa tggaactagt ttttgtttgt ttgtttgttt 102001 tttgagatgg agtcttgcgc tgttgcccag gctggagtgc aaaggtgtga tctcggctca 102061 ctgcaacctc tgcctcctgg gttcaagcaa ttctcctgcc tcagcctcct gaatagctga 102121 gattacaggc gcctgccacc atgcctgact aatttttttt ttgtttgtat tttttagtag 102181 agacagggtt tcaccatgtt ggtcaggctg gtctcaaact cctgacctca ggtgatccac 102241 ccacctcggc ctcccaaagt gctgggatta caggcgtgag ccactgcacc tggcccggaa 102301 ctagttttaa aacaggaaac agttgatata ctgaatggaa aaacaataca atttgaagtt 102361 gaaaaaacaa aataagatgc ccagttaaat ttaaatttca gttaagcagc taatagttat 102421 ttagtataag tacaacccat atacgacaat tgcagtattt gttatttatc tgaaattcag 102481 acttacctgg gcatcctagt atcctgtttt ttgttttgtt ttgtttttcc ctttgttttc 102541 ttttttttcc ccgaaatctg accaccttaa ctttaaggta tttattcatt tttaaaaact 102601 aaatattttt cggcagtcag aactagagca aagataaatg atcccaggac tctgtttagc 102661 aggcagtcag gaagtgtgac agtgtggtgg gtggcagccc cggccaggcc tttcctcttc 102721 cctaaactgc cacagcagga ctgccacact tgggaatccc agtttccatc tgagcagccc 102781 ctccagagtt tggaaggagt cagtgcttta gcctgaggag ccgtggatgg ctctaacact EPI-109 874

102841 ttgcttgtcg gttgaataaa aatcaaccca aaggtggcct acactcattg aagtaggaat 102901 gccagaactt cagtggtgtc acatagaaga aaatatctaa gtgcttaggg agatggcagt 102961 gctagtggat ctactggatc attaagactc actcacccac ccagcgcagg tctagaggac 103021 acacccttgc cacactggga agtgtaaatg agctccagca tctttatttt tttttatttt 103081 ttatttgttt tattatactt taagttttag ggtacacgtg cacaaagtgc aggtttgtta 103141 catatgtata catgtgccat gttggtgtgc tgcacccatt aactcgtcat ttaacattag 103201 gtatatctcc taatgctatc cctccccccg cccccggtgt gtgatgtccc ccttcctgtg 103261 tccatgtgtt cttattgttc aattcccacc tatgagtgag aacatggggt gtttggtttt 103321 ttgtccttgt gatagtttgc tgagaatgat ggtttccagc ttcatccatg tcccgcatct 103381 ttaaaaaaaa aaaaaaatct ctaagtggtg gctcttctct gtagatcagg agctgtagtg 103441 agcaatgcta caaaactgga gtttctaaat acagggggga tggtgggatt ctgaggaagg 103501 acaggccacg tggtaacact tacaaaagac caagtgggtg tggttgccac tgtggacggt 103561 ggagccaaag cagtcctcag aatagtctga cccccagagg tctttggcat tggctggttg 103621 atcatggtgt ccctggaatt gaaatagaag gacggtctac taaattttta cctgatctgt 103681 ataagcagaa gagttctatc tctagtgaac agaagtctaa ctttagtcac cagaactgag 103741 agtcaattca atcaattccc agatttgaca tagtttatag acctagaacc ccttgaatga 103801 aaggtaagct ggctcccctt gaggaaggac cctgttacat ttccggcatt ttattctgat 103861 aatctttttt cccagccttc cccaaagcaa cttagggcca tttaccaggg aaagccatgg 103921 aggaaaagga aataattagg ctatttggag attccaggac actggctcta cgctgacacc 103981 agttctaaga gacccaaaat atctttgtgg tctaccagcc aaagtagggc ttcatagagg 104041 tcaggggtca ctagagtttg agctcaggtc tgtttcactg tgagtctaga gggtccctga 104101 acttatccta tagttattcc cccagttcca gaatgcagaa ttgagctgag agcagtggct 104161 catgcttgta gtcccaacac tctgggaggc gaaggtgaga ggatcacttg agccaagcgg 104221 tttgagacca gcctgggaaa tatagtgaga ccccatcttt taaaaagaca aagaaaaata 104281 aagaaaattg acatggaaaa ataatataaa atgtgaataa tctcacatct actaaagaaa 104341 ttcaatctgt aattagaact cctcccacag agaactataa gcccagtgcc cccatcaact 104401 ggagaaacag aaagaaacaa tcttcttaac agaaagcata attggaatag agatactctg 104461 catcggggaa gaatccccat attgattctc tgatccatag agtgaaggcc aagtggaagc 104521 ctttggaact ccctctacct gccaagatac taaacaaaac aacactgcac gtctggagga 104581 attgtagcaa gaacttgaaa gatgaaggat gatgatgtcc acctctctcc attcagctca 104641 cctatctggt ttgtgcagaa gacaaatagg tgttggaaaa tgacagtgga ccagtgtaaa 104701 cttaatcagg cgggggctcc agctgcagct gcaggatcag gtgttgtttc atttctgcag 104761 ctaatcaacc cttctcctgg cacctggtgt gcagatggca atttttcttt tctattatct 104821 gttagtaaag actatcagaa gctgtttatt ttcagttggc aaggtcagca atacactcca 104881 agggaagagc agtctgtctc agatcttacc gatgcctggg gatagggagg gagtggcccc 104941 ctcaccgtct ccaaggccta gtcctctgct cctgctactg gcagcaaatc cacgcaggtc 105001 tgcaacaacc tcaattcctg cctcctcaga agaaagaatt caattgaggg acgtaagaca 105061 gaaggagaga ctgaggcaag ttttagcaca ggagtaaaag tttatttaaa agctttagaa 105121 taggaacaaa aggaaggaaa gtacacttgg aagagggcca agtggacgac ttaaaaagca 105181 agtgcgtggt ttgacctttt gacttggggt tttatacgtc agcatgcttt cggggtcttg 105241 cgttatttct cccctggttc ttcccttggg gtgggctgtc ccatgtgcct gcctgagccc 105301 actggctcaa ctcctgagat cttataggga aactactgct caccagtttc gagtgttttc 105361 tatctattag gagccggctt ttccctgttg ccgggtgtga ccaattatta ctttagaaag 105421 acagtcaaca accgccagac catcacctga tggtcacctg acactcctgg tgtgtggggt 105481 atggggagcc ctctcctgcc ctgctctttc tgactagcta cccactataa cactcccaga 105541 gggacctgca cattttgtgc tctttgcaag acagtgcctg cccagcacct gtaggcctgc 105601 tcaccccttc agggtcatga tttttgcttt ttaccgcagg tacccataag caaaacatgg 105661 cattgttcac catgctttta cattattcac ataattttaa gttatttaca caacaatgta 105721 aaaccatggt gaaccatgcc acatgttgct tatgggtacc tgtggtaaaa atcctgctac 105781 tagctcattt tgcagtgtct ataatgacag gtaatgctcc attcactcct ttatgacact 105841 tgcaaaaact gagaacataa cgcctcccag ttaagcaggc atctgggcaa tgtgaggaga 105901 acagaaatag accacgctgc atttatctct cttgatgaca ggcattgaga tttccacttt 105961 ttctggtttc ttattatgtc tctactgggc attcttacat acatcttgca cgccatggaa 106021 agtttctcta gggcagtggt tcacaaactt tttggataca gaatactttt atgtgcttga 106081 aaactgagga ccccatacag ctttagttta tgtgggtgta aggttctagc ccaaactgaa 106141 gtccgaaggg agttggtggg tgggtgaggg gtagctgaaa aaacacccga ggaatcatag 106201 gcagtttgaa catggcctta tcctctctct gggcacgagc catatgtcca gtgtcagcag 106261 ggtaattata ccttttacag acaatagagg ctctgaagca atcacgagct cacgtgagtg 106321 gtcacctaat gcacctcaag tggcatggtt cataatgtgc ggagtcgtgt gcctacgctc 106381 caaacccact gagtcatggt gcaccaaaaa gtggcctcag cctgctcctg actaaagcgc 106441 agccatcttc cttacactcc acccctaggc caggggcatc ctccaggtag ggacatgtgc 106501 ccgtagggtg gagccctgaa tccataatcc acagcaacaa tacggagagc aacagctcat 106561 gactaggatt ccagctatgc tacttatgac tatcagggcc cagcgtaggc cagagcccag 106621 ggatgtctac catctctgca gggggtcatc agtaaggctc ttgactacct taatctcctg 106681 tgagacccct tgcagggctg ctgttatgtt ctgccaattg tcagggataa aggtacaaca 106741 ttgtgttcct aaaagggcac aggtgcctcc ttaggcagca gttactatgt ctaagaccat 106801 tcggtttcgc aacaccacct ttctgatctg atcaacctca tccattaatg ggaagagggc 106861 cactcaggtg taattcagag cctgagcagc atgctctgca agagcagtaa cttggcttct 106921 acagttgtga cacacactcc agggctagtg cctgtcaagg ggtaaaacca ccagggtgct 106981 cattacactt gcaaaaaccg agagtgtagc acctcccagt tatgcaggca tctgggcaat 107041 gtgagaacag tggcaggtac atgaggccac cctcaggtat aatgtccagt ccagtttgct 107101 tataggtaag gccaccctgt gtccccacag acccataaac tcccaggggg cacacagtcc 107161 atcgaggccc cttggtgggg ccgcgtcttc caccatacct ttggtgtggt gacatgtatt 107221 atgcttacac acactgtgac gggtacccat cccacagtgc tattacccca gtgttgctat 107281 atgcaccaca gtgcctgggc caggggtact gcacgttacc tcactagcca gccccaccca EPI-109 875

107341 tcataaatgc tatgggccag ccagggaatg gctgtgctgt gggtcttgtg gcatcctttg 107401 tccaaaactt gccacgttgc gttccaggca tcagccatgg gaccccaagt ctccagccat 107461 gtctggttct ctgcagatgc tgaatgtatg tgctaaggca agccatctgc agctgctaga 107521 agggcggtgc agatccaaca gttggaaaca ttggtcactt cagtgtaggt gtgggcccag 107581 tccacaatgc agttggagca tgttaaccta cagttggaat gacagagtag gcataggtac 107641 taacagagga aaatcacatc cctcaggtaa aatacaggct aacctttcat ccctggataa 107701 caatgcagcc cccaaggggt tctgccctgg gcaatagtac cacacctttt cagctcccca 107761 tggttccttt gggtcctgta ttcatgcgaa agtcacaggg gagcttgtag taggccacac 107821 agacagtaca tttgaaccct ggaggaaagt ttcttccctg gccgttttcc tacaaacagt 107881 taacttcggg gaccattcat tgaacaccca aagagtgaca tacaagtcat actgtaggcc 107941 ctccccacag ggagctacga tggacaacca ccagcagccg ggggcttgga ggggctatgg 108001 ccacagccag gttttctgtt cccctgcctt cagggacgtt ggggcaggca acaacaggtt 108061 actgttcatc cccatacctg gtcagaggcg gttacccttg gtgtgtatct gcaactgaat 108121 aggggtggtg gcccatgtaa caaagcctcc acctgggctg ggctgctttt ccatggccat 108181 tcattcaagg tttggagcat caggtccagc ctggaacttc agccctgcaa agacaggagt 108241 gtgacatgca agtaaaaccc attcttcaag agctcgctat atcactcaat catacccaca 108301 gcttgcaagt tgtgcggtac atggaatccc tactttatgt ccattgttgt gcctgttgtc 108361 cagtaaaatg tgtcccccat cactctcaat gaccaaaggg caaccatata gagcacataa 108421 gtgttgcagg gtctggatgg tgtgctgttg gttggccacc ctgcaaggat aggcaaacaa 108481 caggcctgtg gctgtgtcca cagctgttag cgcatgagta tacccttgtg acttcggcag 108541 cagcccaatg tagtctactt gccacctggt caagggcact tgccctgttg tcacttgtgt 108601 agcactggac agctgcctcc atttagggta tgcctgagca catgccgggc atttctgaca 108661 agcctcccaa atgtcttgca tgggcagaga cagaccccaa catttattga cttgttgcat 108721 cagtttaccc cctgcatgtc ccagtttccg gtgtagctac aaggccacat ctcatgtaga 108781 tgccaactct aaccatcgga ccttggccaa ggcttctgcc tcgtcattgc tgggggtggc 108841 cagaggcata tggcctgaca aatgataaat agttacatct ttgcaatgac ccatttccca 108901 gaggtcttgc tacatgggtt ggtggcccca aatgggttgg tggccaacta gccaattctg 108961 tattttccaa gtagttaaac acaaagttag gcctccatag actgcccagc tatcggtacg 109021 gattaccata ggtgtctccg ccttgttgat caccatccat actgctttaa attcagccca 109081 ttgactactt tgtccacatc tggtttcaaa ccatatggtt ttggtactaa gttggactgc 109141 aacactggtc caagcaggag tagcacctcg actagaccca tctgtgtgcc atgccccatc 109201 aggaatagag ggatgccctt ccttaaatgg cagtggctca gggtcaaggg gtgcctcagg 109261 ccccatggcc ttctcttgca ttaggactgc aggtcccaag acctcttgca actctgctgc 109321 taatgggctt gtgctcagcg tactctgttg ctccaagtaa gtgcctcact ttgccaaagt 109381 ggatgtctgc accatcccag tctggggggt cattacacat gaatgcaccc atcccgctgt 109441 caggtaagtc atccacactg tgactgtagc ccatcctatc acttctcaca agcctgaagg 109501 gcagcatata cagctgctag ctatttctct atcaaggaat accagagctc agctcctttc 109561 catagttggg accaaaagcc tcctggcatt ctcaggcact ctgtgtgctg ccacaggccc 109621 aaactaaaac catctgtggt cacatgcata tccagttcaa atgggcaccc cttgtcaaat 109681 acccacaggg ctcgtgcctg ctgaatagcc cacttggctg ccaggaagcc agtctcagcc 109741 acatcagccc aatcccagat tgctcccttc tttgttaact gatacaatgg ttttatcatt 109801 tgagctaaat gaggcaggaa tgtccaccaa tatcccagga ggctcacaaa agtttgcagc 109861 tgcctcaccg tggtgggcca gggatatgcc taaattttgt caatgatagc ctcttgtatg 109921 gccttcatct tacccgacca gataactccc aagaatttag caggtaatcc aggccctcgg 109981 accttggatt tgttgatggc ccaactgcat gctgccaaat gttgccacaa gaggggtgcc 110041 actgcttcta aatctgcaag agaatcagag gttaacataa tatcatcaac gtaatggaac 110101 aagtggactc cctttggaca ttttcaggct gttaaatcca tggcaacaag accatgacat 110161 atggtggagc tatgcacata gccctgcagc aacactgtga aagtccattg tcatcaaggc 110221 aaactgttcc tggctctcta gagcaaggtc aactgagaag aatgcattgg ccaagtccac 110281 cacatagtgg tactgtccta attccattgt cgagtggttc atcaaatcca tgatagatgg 110341 cacagcttcc aagccatgta aaatatccac ctccagaatg tattcaggta tgggagagac 110401 atacacagtg tataagcaag gagccaagtg gccaatgcca aggtacagag atacaggttt 110461 cactttcact gactggcctc cgtaaccttt aatatatgca gatttgccca aaaacttaac 110521 tgggttccca taaacaaggc tacaatctat gccagtatct accagcacca gcacccactg 110581 tacattggtg ggggaccagt ggattgccaa ttccacatgt ggcctctggt catctggtgt 110641 ccccccaagc cagacacctt tggccagttc cctagttgaa cagaaaaggc tctacatttc 110701 cacctggctg cagcaagtag tctctgagct gggtaggacc aggtcacaca gcaatgcctt 110761 tctccccttt gggcatttt'c cggaattgct gccctgcata caactgtctc cgcaaagtta 110821 ggagtatttc attgggctgc ttatcaattt tctctcagtc aaccccagcc aaaatcaaat 110881 ctatccacat ctgtgagcgt gtcactcgtt ggggccccct ttttttatgg gggagccccc 110941 tgtgggtggg gtaacttccc cttctttatg gtgtggaccc tccaatcccc ctgaaggcct 111001 tctgcttccc tgagagccgc catggcagtg gttacttcat gtatgcggtg ccctacgtat 111061 ggggtgagga cagcagctag ggagccaaag gggctcagga gcatcaaacc caacatgaga 111121 tccctcatgt gggaggtgaa acatttatca tctggccctc aggtattcag gacaaacata 111181 gcctgccgca tacccatctc ccgaatgact tacaccaaat tggcatatga ctgccattta 111241 ctcacagttt tgggcatttc accagcatta ttccacacag ttcatatggc tgcctgtagc 111301 cactcagtca gggtgtggtc tccttgcgct gccactaacc acctgctcac ttgcagccgc 111361 tgacagagag aggggtgagt catggtggag gccagcttgt ccatctcaga ggtggaatgg 111421 gagataccat ctgctccctt gttccacaga cgaagcatcc aggcaggcag gggttcccct 111481 ggacactggc aacactgctt gcctaattcc tgcaactcag ttggggtaca ggcaatatac 111541 gaaatgtgtt gcattatggt ggggagtccc tgagtccacc cttggagccc cagtggctgt 111601 tcatgatcta ccttctgtca gaccaccggg tgagcccgca acaggggttc ttcctccttg 111661 gtatgaaact gagtggggat ctccagacaa gatgatggac ccaggcctgc attcatggta 111721 gcctctaatt ccttttccaa gctctgaagc cacacctcca ggcatcctgc ctgcacctgg 111781 aggtccccat tcatggcagc ctctaattat tttccagatc ggtgtagcca gacctccagt EPI-109 876

111841 ctgcatccct cagggactgg gtgtgtactt ttcttagcac agttaaaaat gcccatccaa

111901 ctctgccagc aaaggctctc tccttcttgg tgctctgcac ttccagctgc ttcagcgcct

111961 tctccatgct catgggggac ccatctactg ccacccaggt ttccactcaa gcccaccctc

112021 acagcacggc taccaccggg taccacaacc catgttgtgg tcacatggcc aacctggaat

112081 cagcagggac cgaaggctca cttaccttag gatcctgttc gtgatgccaa ttgtcaggtt

112141 ctagcccaaa ctaaagtcca aggggagttg gtgggtgggt ggcaggtaac tggaaaaaca

112201 ctcgagtagg cggtttcgac atggctttat tctctctctg ggtgcaagcc atatgtagtg

112261 tcagcagggt aattttacct tttacagaca atagtggctt tgagccaagc acgtgctcat

112321 atgagtggtc acctaatgca cctcacatgg catggttaca taatgtgtgg agttgtgtgc

112381 ctgcctccaa acccactgag tcatgctgca ccagaaggct gcctcggcct actcctgact

112441 aaagcacaac catctccctt agagtgggct aaatctactg ctatttatac tattagaaat

112501 tttaacacag aagttttaaa tatttacatt gttaattgat tttgaaataa taagcccatt

112561 acaggttaac ataattaaca tacttttatt aaaaatatct gtatttttta aaagaaaaaa

112621 aattagcaac aacagtgatc cttggaatcg tcccacctca gcctcccaag tagctgagac

112681 cacaggcgca catcaccatg cgagctaatt tctatatttt ttggtagaga tgggatcttg

112741 ccatgctggc cagggtggtc tcgagctcct aagctcaagt gatcctcctg cctcggtctc

112801 ccaaagtgct gagattacag gtgtgagcca ccacttctgg ccagaagctg gattctctgt

112861 cttgttctcc atccaatctg ttagactgtc aaatgccaaa taacctttgg aaaattctac

112921 tcgtaaaata aggagagaga taaataactt ctgagtatca tcattaaaat agtttgacct

112981 catggaccca ctgggtccca tgtggagaat agctctaagc taaagagtag aatggctggg

113041 aggggacata aacattcagc ccatagctgc tgaccacaat aacacatttt aagtctcttc

113101 ctctcctgct ccttgtgatt gcagacagac tcaatctgta ggagagctgt agagagaaca

113161 agctcaagcc cctgattttg cctacaaaga aagctgagcc cagcaaagtt aagggactta

113221 cccaaggtca cacagccaca cagcagagct ggggctgagc tccaggtgtc ctgctacaga

113281 ggccacttct ttctcccact agggactggc ctgtgattac ttcagaaaac aatggtcagc

113341 taactgattc tgaacgccct ttgctggtaa aagctaatct cctgaggaaa aatgtatgca

113401 ttggctgggc gcagtggctc aagcctataa ttccagcatt ttgggaggtg gagacaggtg

113461 gatcacttga ggtcaggagt ttaagaccag cctggcagtc atggtgaaac cccgtctcta

113521 ctaaaactac aaatattaag ctcggcatgg tggcaggcac ctgtaatccc agctactgga

113581 gagactgagg caggagaatc gcttgaaccc aggaggcgga ggttgcagtg agccgaggtc

113641 gcaccactgc attccatcct gggcaacaga gtgagattct gtctcaaaaa ataataatag

113701 taaaataaaa ataaataaac aaataagtat gcatcacctc aggtggtcag tcagctttcc

113761 caagacccca aagcacacaa tgttctttct ggtatgagtg acatggggtt cacagcacca

113821 caaagtccat gacttttccc tcagaagtga atgcatggct aattattttg tattttttgt

113881 agacatggag ttttgccatg ttgcccacgc tgctctcaaa ttcctggact caagtaatcc

113941 acccacctca gcttcccaag gtgctgggat tacaggcatg agacaccgca tggcctgcac

114001 ctatagtccc agctatcagg aggctgaggt gggaggatca cctgaaccgg ggaagttgaa

114061 cctgcagtga actgtgatcg ctccggtgca ctccatcctg ggcaacagag tgagatcctg

114121 cctcaaaaaa aaaaaaaaag tgaacacaca tgctggggaa gaggcctgca ggcacccctg

114181 ccagttctgc accagagcac actgtagcag ccctgctgtg atgcaggaag cagctccagg

114241 tcctgcagtc tgaagcatgg agcctgaagc ctggagcccc ccatccaatg ctgcgccatg

114301 ctcaccagta tcccccagca tcagcaccga ggcaccagct gcagataaat ttctcaccta

114361 aaatgttgag agatgttgct aaactgtcct tctaagggta tgtataataa tacggtcctg

114421 ccgatactga ataagactat ctgtttcatt acatcctcac aatactgaat atcattagca

114481 acttgaattt taaattgtgc taatcaatga aaatgattgc ctaattacta gtgagttgag

114541 gttatttaac attaatactc cttctgatga aatattttgc atttatcaca ttttacataa

114601 attctctcta tataattagc actagaatgt ccgacttggt tttcattgtt cctcacctgt

114661 ttggaaacac attaagaatg agggagagaa tggatgggga ctcacctagg gatgcatgga

114721 gctggtcggc agccactctg aggccctctt aacacttccc caccacacac ttaatttccc

114781 ctggtttgtc catagataca tccaacaatt tttatgtaaa taagaaagac tcagctttca

114841 atggaaaatg gtaggttgga ttttatgact gaagtggcaa aaagaaataa gggattttat

114901 tatgggggag gtccaaaccc tggtgaaaaa cgaaattcat tgaaattgtt tgaaaattca

114961 aggattaaat cagattattt tggattcagt aggaattaga ttactttaaa gccccaggat

115021 actttattct gtagaatgca tggaaagtat agaaaagaga aacaaagagg gaaagtcatg

115081 gctaataacc tggaaggggt aaatagggag ccaaaggcct gtgggacgta accaactcag

115141 cattccactg gaggctttat gatcaaatag caagctattt atcatgaatg caggatgtgg

115201 gcaaactcac gactgctccc actgccagaa ggtttgctga gggcaatcac ttcctggcac

115261 cgagctcctt gaggttatct actgggacat ctggagaatg cagtcttgca agcctactct

115321 ggacccagca gctgacccct tcttccatgc ccctcttcct gctatctctt ttgcctaata

115381 aatatggagg gctgtgtaaa gctcagggcc cttgtccact agaggcaaac tgcccgctga

115441 ccccttcttc caaatatgct cttttgtctc atgtctttta ttcccgcttt caccccactt

115501 tgttcagtcc ccctagggcc gtgtgggtta catagtggcg ccctgaacag cgacagaatc

115561 aggtgctcta caagtggcgt ccgaacacag ggactatgag gatgtgaatg aagaagatct

115621 gctggagcag aggaattgaa attgacaagg tgaatgggga tcccgggaca agtctgccgg

115681. cagcagatat aaggtcagtg ccctaaagag gtactgggag cagtgcctta aagtagtact

115741 gggaatggga agttttctga atcagggtaa catggggcag aattggtctg ttgaagaaaa

115801 acattatgtg cagttgctta aagttttgtt gaaacaaact ggtgctcagg ttagttctca

115861 cattaactac gatgctacag gaagtcatta tgcataaccc atggtttcca caggcaggga

115921 ctcttgatgt agaaaattgg gatagagcag aaggattaaa acaggctcat caaaaaggtt

115981 ttcaagttga ttcttcagtt ttctccactt ggagtttagt tcgtactgta cttctgccat

116041 tatctccttg ttattctgcg ggacagcagg ctgaatgtaa aaatctgaaa gaatctgttg

116101 tcccacccac agctccagtt gaaaataagt aataggagag ggaggataaa aattggccta

116161 taccgccccc tccagttgca gaaacatctg taccgcctcc ttcggtggca gaaacagaga

116221 ccccaataca aagaatttta cgctctgccg ccacggctgg agagccctta ggaccttgca

116281 cttttcctat ttccgtaagt cctgatccaa ataatccaca gcagcttaat catgaacaca EPI-109 877

116341 ttccactaga gtttaagttg ttaaaggaat taaaagtgag tgtggtaaat aatggcatac

116401 agagcccatt cactttagga ttgctagaat ctatgtttgg tgctatgtgt cttttaccct

116461 ttgatgtgaa acacttggca tgaacttgct tgtctgctag cgcatatctg acatggaatt

116521 taaactggca agaacagggt gcagaccagg ctagacagaa ccatgctgct ggaaatggag

116581 acattacaga ggataggcta ttgggtaatg gcccttattc tgacctggta catcaactag

116641 cactcacaaa tgctgcttat cagcagtgca cacaggctgc taaatgtgcc tgggccataa

116701 ttcctgaaga gggagtccca gtactatcat ttttacatat catgcaaggg tcacaggaac

116761 cctacgcaca atttcttgca agattacaag aggcagtgag gcatcagatt cctcatacct

116821 tggctgcaga aatgctaacc tttactctag cttttgagaa tgcaaatgca gattgtaaat

116881 gtgcactggc accggttagg tgtacaaaaa cttgggaaat tttctcagag cttgttaaga

116941 tgtagcaact gagctttatc gatctgcaat gttagctgaa gcaatggcta atttagctgt

117001 tgacaaatct aaaaagagcc aagggtcaaa ccctaaaatg ggaaaatgtt ataattgtgg

117061 aaaaactgga cattttaaaa aggaacgcca ccagatctca ggacagaaag gatcttacaa

117121 tgcttttccc cccggccccc agcggaaaga acacctggac tttgtcctcg ctatgacaaa

117181 ggaaataact cggctaatca gtgctgctca aaatttcatc agaatggcac ccccctgttg

117241 ggaaatgaga tgggggcctg tacccgggcc tcacaaacaa tgagggcatt cccaattcag

117301 acctcaaccc tgtttcaggc atgggttccc agaggcatat tgagtccctc acccgaggaa

117361 ctccaggaag tgcaggatta gatctcccag ccagagaaag ggttacataa ggtggggaag

117421 acaaacccac caagattctc actggcattt ggggaccttt accagcagga tatatgggac

117481 taattttagg caaaagccac cttaacttgc aaaggcatta ctgtagtccc agaagttgtt

117541 gactctgatt atgaaggaga aattcaagta gttttattgt cacgagatct tcgggttttt

117601 gaaccgagag aatacataat gcaattatta cttattccct gcaaattaca cccttctcca

117661 tgaaaggaga aacaaggaaa taaagggttt gggagcacag ctacacggga aatctatcta

117721 tcccgaccca tagcctctaa tagacccacc tgtgtagtac aaattaaagg aaagaaattt

117781 tatgggttta tggataccgg agctgatgtg tcagtgttac cagcaggtct ttgttcttag

117841 agctcccaag atggcggcaa gccttttgtt ctctgacctg gagttcttgg cctcacagat

117901 tccaaggaat ggatccttgg gccatgcagt gagtgtcata gctctattag aagctcttcc

117961 aaaagtcgtg ctgctatcta tggactaaaa catactcaaa caataatgac ctctggcgtt

118021 taggctcaat gctcagagct aattgcagtc attcaggttt tacagctcac agcttcagat

118081 cctgtcaaca ttgtctgtgt tcagtttatg tcgtaaatgt agccggtcac atagaaactg

118141 ctacaattaa aagtacgcta aacccagaac tgctaattta tttttaagac ttcaacaagt

118201 tatttgttct agtgcagctc cttttcatat ttctcatatt ccttctcaca cacaacttcc

118261 tgggccgcta tctctaagta atgagaaaac agacaaactg attgcctctg tgtttcagca

118321 agctcaacca tctcatgtgc ttctgcacca aaatacttcc gcccttactc acatgttcct

118381 acaggtttgt attatattat gcagtatatc cctcgagcca cacctataga aggatgtaat

118441 ccacgaggtt tggctccaaa tgaaatctgg caaatggatg ttacacacac agcaaccttt

118501 gataagctga gctatgttca tgtgactata gacacttatt ctcatatgct gcctgctaca

118561 tgccaaacag gtgagacagc tggtcatgta cagcgacact gtctgtcatc atttgctcat

118621 atggggatat ctaaacaatt aaaaactgac aatggacccg cttatactag tcatgctttt

118681 aaaaatttct tgcagctttg ggctataacc cataaaacag gaattcctta taatcctaga

118741 ggacaaggca ttatagagca ggcacatcaa acattacaat gcatgttgaa aagacaaaaa

118801 gcgggtatag gaggccaact accacctcaa taaaaactac atttagcctt atttacttta

118861 aattttttga ctcctggtat ggatggtaag actccagcag aaagacattg gcaagtgtta

118921 gaagaaaaga ggaaaattta tccaaaagtg ttatggaaat ccctggaaga aggaaaatgg

118981 aaaggtctgg tggatttact gacgtgggga agagagtatg cttgtgtttt tacaggagat

119041 ggacaagccg tgtgggtgcc ctcaaggtgt gtgcaaccat ggaacgggag actagaggaa

119101 cccagggtgg ccaaccatgg acagggtccc cccggtacga gccatgagcc agctgagcct

119161 gagtgcaaag acggagagaa ggccaactgg agtcacaaca cagttctaat gttatatttg

119221 taaagaatat cactactcaa cttacagttt gtgtttatag atatagatat agatatagat

119281 atagatatgg atatagatat agatatagtt atagatatag atagatatac actttaagtt

119341 ctagggtaca tgtgcacaac ttgcaggttt gttacatagg tatacatgtg ccatgttggt

119401 ttgctgcacc catcaactca tcatttacat taggtatttc tcctaatgct ctccctcccc

119461 cagcaccgcc tcccaacagg ccctggtatg tgatgttccc tgccctgtgt ccaagtgttc

119521 tcattgttca atttccacct atgaatgaga acatgcagtg ttttattttc tgttcctgta

119581 ttagtttgct gagaatgatg gtttccagct tcatccatgt ccctgcaaag gacatgaact

119641 catccttttt tatggctgca tagtattcca tggtgtatcc ttatgtcttt ttgacagcta

119701 agaaggacca gctccaggta aacaataccc aattgacctg taaatcttac caattatatc

119761 actgcattaa tcatagcaca ttgcaaacac ataatatctc tactttgatg attttaggcc

119821 acatccctgg gctatgtatt cctgttaatc tgtccgaggc ttgggctgcc acacctgctt

119881 tgcattttgt gaaacttctt ctaactgagc ttactcatca tgtctgtaga gccttagaca

119941 taataatttt agctattgtt tccttggtcg cactaataac ttctgttgtg atgtcctctg

120001 tagctttgca taattctatt caaacagctc agtacatgga gaactggaca cacacagccg

120061 accaagcatg gctacttcag aataaaatta acactgagtt acaaactgaa gtggtgttat

120121 gggaagtcag ggaccccaaa gagagggacc agctggagcc acagcagagg aacgtaaatt

120181 gtgaagattt catcttaata cggatattta tcagttctca aataatactt ttacaatttc

120241^' ttatgcctgt ctttaatctc ttaatcctgt taccttcgta agctgaggat gtgcatcacc

120301 tcaggaccac tgttataatt gtgttaactg tacaaattga ttgtaaaacg tgtgtttgaa

120361 caatatgaaa tcagtgcacc ttgaaaaaga acagaataac ggtgattttt atggaacaag

120421 ggaagacaac cataaggtct gactgcctgc agggtcgggc aaaaagagcc atatttttct

120481 ttttgcagag agcctataaa tgaatgtgca agtaggaaac atatcgctaa attcttttcc

120541 tagcaaggaa tattaatatt aataccctcg gaaaagaatg cattcctgag gggaggtcta

120601 taaatggccg ctctgggaat gtctgtcttg tgcagttgag ataaggactg agatacgccc

120661 tggtctcctg cagaaccctc aggcttacta gagtggggaa aaactctgct gtagtaaatt

120721 tttggtcaga ccagttttct gctctcaaac cctgttttct gttaagatgt ttatcaagac

120781 aatacgtgca ccactgaaca tagaccctta tcaggagttt atgatttttc tcctgtcctg EPI-109 878

120841 tttcctcagg agcatgtgat ctttgttctc ctttttgccc tttgaagcat gtgatctttg 120901 tgacctactc cctgttctta caccccctcc ccttttgaaa tccttaataa aaacctgctg 120961 gttttgcggc tcaggtgggc atcacggtcc taccaatatg tgatgtcacc cctggaggcc 121021 cagctgtaaa attcttctct ttgtactctt tctctttatt tctcagccag ccgacactta 121081 tggaaaatag aacgaaccta cgtgaaatat tgggggtggg ttcccccgat atgtgatgtc 121141 acccctggtg gcccagctgt aaaattcctc tctttgtact gtctctcttt atttctcagc 121201 tggccaacac ttatggaaaa tagaaggaac ctatgttgaa atactgaggg tgggttctcc 121261 caataaagtg gtaatgttga aatccacagt tctatggtta ggggaaaagc acaaagcttg 121321 caattgcagc agcaattgca ttgtcatttt aatcacactc atatttgtgt aaccaactta 121381 gaatataacc aaagtgagta tctgtgggac gttgtgaaag cccatttgca gggagctttc 121441 acatctaaca tcacctttga tattggtgaa ttacaaaaca aaattcttga tttacatagg 121501 caaattcaag agtttctgcc ttctttagaa gactggacca aattccagca aggcctggag 121561 agcctcaatc cttggactta tctaaggcac tacattaaca tcttacatgt agttcttgga 121621 ataatattgt tttgtctctg tcttctgttc atagcctgta aaattggatg gaccaccaat 121681 cggaaaatga gagctgccca ccctggcctt acattctttc aattaattca taaacagaaa 121741 gggggatatt tagggagcct aaggctcgtg ggactgacca actcatcatt ccactggagg 121801 ctatatgata aaacagcaaa ctgtttatca tgaatgcagg atgtgggcaa actcacgact 121861 gctcccactg ccagaaggtt tgctgagggc aatcacttcc tggcaccagg ctccttgagg 121921 ttatctactg ggacatctgg agaatgcagt cttgcaagcc tactgtggac tgagcagctg 121981 atcccttctt ccacgccccc cttctcacta tctcttttgt ctaatcacta cggagggttg 122041 tgtaaagctc agggcccttg tccactagag gcaaagtgcc ccctgaccgc ttcttccaaa 122101 tatactcttt tgtctcttgt cttttattcc cacgtttgcc ccctttgttc agtttcccta 122161 ggtccatgtg ggttacatag tggcaacctg aacaatgaca gaatcaggtg ctctacagaa 122221 ataacttttt aaggaaagat ttgggactta gagaccccag gagacataca caaaaatgat 122281 aagaggatgt gcccaaacca gtcttaaagt tgtggcacag ggtgaggaag atgaagctgt 122341 tactgaacct cagagagtga ctggtgttac agcaaaagtt agcaatggcc tgaagggagg 122401 gtttctgaaa tcaaatatga atgattcccc ctcagggaac ccaaccttgg gaactactgc 122461 atggttctct gtatgggaaa atatcattaa tgcaggataa attgtgaaat atcacaggaa 122521 gcatcctgca tctagtcaat cttctgtttc tggggtggcc tgtgcagctg tgcaggcaga 122581 ggcccaacca tcctggtgag tggcacacag ggactgagat ccagccacac ctaccaggcc 122641 atgctctggg aagggggtgg gacctgggca aaggacacct ctctaggact gcacagaagc 122701 ctttgtgggt gggtgggaca ttcctgtgat ggccttctgg ctgggcacta tgaaatgctc 122761 tgaagatttt tccttgcact gttgcactaa ccccagtcct ctatcactgc cccttcctcc 122821 tgggcgactt cactgatgtt gtggccatgt gaattctctg gccaatgaaa tgataaagat 122881 gatatggcct ctgccaagca gacactgtaa gtattattgt atgatgcttt tgtctctttt 122941 tttaaagtta aagcagttta ttaagaaaat aaaggaataa aagaatagca ctccataggc 123001 agagcagctg cctctgtctc ttatattttc ccctctgcct caagcccaac atgcccaaaa 123061 ttggggctgc tggttcagcc tgggtctcag aataaagaca tgagccacag atccattgct 123121 gacccatgat ggagatggac acaagagaga aacacatttt tgtcatgtta gccactaaga 123181 ttttgatttg gaggccattt gctacagcaa tataacctag cgtgaacaga gagacacagc 123241 gatgttccat ttcttttcaa cctggaacag gagaatttca taggtgggcc tcaatttcac 123301 tttagtatct tatttagaca agaaagttca tactgttcaa atgtcatgtt taagagtgct 123361 ggcattatca ctgctgtggc taccccatca gatgttgctc actgactaat cttctcatgt 123421 tagtgaggat ggacaacata tcaggccata attcaaagta gcaaatagga aaagagcttc 123481 atcctagcat tatgggacct taattaatgt cctttcctga caggtttcag aggcttttgc 123541 aggcagcagc agagctattc atctcactga cagtggggaa catggccaaa tggttgcccc 123601 cacaatggag gcagagtttc aggacacttg tctgatctct gcccttgaag gaacagtctc 123661 accctgattg acacttttgc ctgttatgtc caaagaacca atggaaaagc aggaaaatta 123721 ttccttcttc atttctctct tcattattta aaattattct gtcttcactt ctctctcctt 123781 ttctctgctt cctacttagc tctttagaaa tgcaattata atcttttatc tccccttcac 123841 cagacactcc caacagggca agttcatcta actatgtgct cttagttaga cgctacagag 123901 cagaactctc tcccaccaag agactacctt gagacataac agtcaattca caagccaaaa 123961 tatgcccgct atgaaactct cccatctgga aattttttgg ctgcttttac aacctagttt 124021 tgcccacaaa ggcaccagca gtaaccaact caactgcctg gtagacaagg caccaaagcc 124081 agtacccaga ccctctacct gctcacttcc tgccttgcat gccacgcccc ccatttaaaa 124141 gcctctgctt tctgctccaa aggtgaagca gttaccctta aggaaagaag cctgtacttc 124201 ttcccctaag gtagctttgg aataaaagtc actttatacc aaacctagct cttgttaatt 124261 agactctgca agtgatgagc aactgaacct acatttcagt tataattcct atgcttgttc 124321 ttcctgccct gccttgggga cacgcacaca ctcccaggca catacatgca cgtgcactga 124381 gacagctatg tgaataacca acaagatccc cttaggaaaa ccggtgcttg gcctggcctt 124441 aaattccaga cccttgggca tcatacccaa gactgcaaga aagaggaggg gctggacctg 124501 aaaaacttgσ aagggaaggt ccaactgtac aggtattttg tcaggcatgt gatttcagta 124561 taaaattcta gaaaagatga gtgacacttt ataaggagag aatatcaaca aaatttctca 124621 ttttacttct tgctaagacg acagcaggga attgtaagca gatggatggg caatccccac 124681 cttcagcagg ggaggccaag gccccaacac acctggggag aagagctggg ggcagtgaat 124741 ggctgaggct ttcttgggga gctgggccat cttcttcggt tttacttcct gaggaattca 124801 caggcttcca ggagggctgt gggacacaac agagcaagag attcagaaac tgatttcttc 124861 cattaaacca gttatttaat ccaataaatc aaagagaata ctaagagttt tctctgccct 124921 tctcccatca ctgagtcagt gcttgccaca ctcatattcc cactccccta ctcctagcga 124981 ctacggtgtt caagggagcc agagtctagc cctcaccagc cagggtgttt ccctgctctg 125041 gcctgagaga cacaaccacc ctgcacttgt ctctgattga atcgactgtc acattctcaa 125101 gttcacaaga cattggtggt cctctagctt ctcccggaat gtgaacctgt ttgcaatcat 125161 gttcacctgc agattcactc attcattcac agatccttac tgagcacctg ctttgtgtga 125221 gttgctgtgc taagtgctgg ggacacagca tggatagact ggcctgccct caagaagcat 125281 gtggtctatg cagtcctgag ctggctgctc acaagaagag ccctgtagcc atatttctca EPI-109 879

125341 gagggtggtc ctgacctgca tcacagtgac ctgagttgtt tgtcaataca gaaaagggtt 125401 tctcaacctt ggcactattg acatttgggg cctgataata accctttatt gcagggggct 125461 ggctgtgctt tgtttagtag catccctggc ctctacctat ttgttaccag cagcaccctc 125521 tatgttgtaa gaatcaaaaa aatgcttctc acattgtcaa atatcccctc aggggaaaaa 125581 ttgtctctca ttgaaaacta ccgataaaga catttctggc cctgccccca tccttggacc 125641 aacagcatcc ctaatgcccc caactctggg tgagggacca ggaataggaa tctgaatgat 125701 tgcagtgcac agggagctg.t gcacactgaa atcccacagt tatcaccggg agccttacaa 125761 tactctgtga tgtcttctaa atatttttaa gggattaaat taatatcaac atatttccct 125821 ggttaagatg tgttttccta cacttgaatt tttttgagat tttgttttct ctatagttgg 125881 catctatggt aactgtctag aatcagattt tttttttttt ttttttgagg aagggtcttt 125941 cggtgtcacc taggctgtag tgcagtggta caatcatagc tcactgcagc ttcaaccttc 126001 tgggatcaag caatcctcct atttcagcct ctcaagtagc tgggactaga ggtgcttgac 126061 accacaccag gctaattttt aaaattattt ttgtagaaca aggtctctct gtgttggcca 126121 cattggtctc aaactcccgg gctcaagcca tcctcccacc tctgcttccc aaggtggtgg 126181 gatgacaggt gtgagccatc acacctggct ggttttgtca tttctcaatg catatgtata 126241 tatgcacctt tcattttact gaataaaatg gattatcagt ttccaaagat ttcatgacag 126301 tgccgtcact atccgtacta taaaatttat aaaaatttat tacatactgc tctattttat 126361 tctctaatta ttttatcaat gagattataa tttcctgaac tgtaaagaga tattatcttt 126421 ccttaacatt tttacacctg tgttcgttcc tagaatgctg tttggccctc aaaccttgac 126481 cttcacccat ggtggtttct cggggatgct agctagggtc tacttacggg aggttgagca 126541 ctttttcaga ttagtaatgc ctgcgacata ctgtggtccc aaatattttt catatgttgt 126601 tttgccatgg agtctggcca gacactcagt gttgtcattg aacagaaggt ttttggtttc 126661 agactggaat aagcaaaact tgtccgggca gtcagatcca tttctcccaa atttagcctg 126721 cgacaaaagg gcagacagtg agtagctaag gaaaagagga atttgtgggt taaaggaggc 126781 aaaggggtat ttcttccacc caagaacagc cctgagaaaa ccatggggca gaaggagctg 126841 agttctggag tcattccacc tccttagtgg agtcccccac cccacactcc tggtggcagg 126901 cccgccttgg gcagcatcca ggcctcacac cacttctggt cctacctcct accatctgcc 126961 atctttcctt ccttcttaac ctgtgacctt ttcccataca acttcttatg ggtgacaagg 127021 caacaatgga ggggttttga gatctgccct cacaagtcaa ttgctcagga cattctaata 127081 tgcagctctt ctagagaggc aggctgctag gaaaacccag gctcagccac taaccagctc 127141 agtgtgcagg tcggtcaccc tgcctccctc acacagttcc tgctctgtcc caggctccca 127201 tgtggggaga ctgagaccca aacccctcag tcacggcagc tctctcacca gcaccactgt 127261 gtgtgcacat taagagctcc ataaaggcca gttatggtgg ccagtcttgt tattcctgag 127321 ttgttttctt caaaagcaca cagagacatg atgttatatg ataaaaatag aagttctaat 127381 aaaatcccag attttaagaa aattttggga tttcgttcaa atcacattta gagagcccta 127441 aatctatagg gcaccttctg agtttgctgt tttagaggcc tggtctagag cactgttcac 127501 tcggcccagg ttcaggaaat gtcacctgag taaaaagcac tatactaatg catgtgggag 127561 gaaggctcag tggcttcctc atttgccaga agaacagcag gagggaaaaa gacagcctct 127621 gagccaggca gtgatggcaa caaggccagg gcacagagtc tcagcagaaa tggagtgagt 127681 cccagaaagc ccagagtcaa aagcctctgt tgttcttgtt gacactctgg gcaacgccac 127741 agcatgaagc caatactctc accatgagct tcaagtagag gactagagag gatcgagtgg 127801 gctggtgcac ctagctctgt gatctcctca cctaacatga gcccacacag ctaagaaagc 127861 actagaagcc ctgtggtcca tacctgttgg tggagcaaca cctgtttcag gcgttccacc 127921 ttatccatcc gagacaccac ggcatgattc ggggccatgg caagatggca gcttctagcc 127981 tcagtcacag gcttccgttt gccatcgagg cacagcagcg caaagtctgc cagcttcaaa 128041 tccttagccc atgcgtcatt gttatttcct ggggagaaaa agaaggtggc atcatccacg 128101 cctcccctgc ttagccaaga agtctcttct gggtgggtgt ggccattcca ctgacctccc 128161 aaatgcacac actggggttg tggtgatgtg aggaacagag aaggagcttc atcctacaca 128221 agctgtacaa acttcaaata taccaaatat tagtgctgtg tccatgcaat ggaatgttat 128281 tcagcaataa aagggagtga agttctggta catcctgcaa tatgcatgaa cctcgaaaac 128341 gatgctaagt gaaagaagcc agtcacaaaa gaccacacaa taggctgggc acggtggctc 128401 atgcctgtaa tcccagccct ttggaggcca aggtgggaga atcacttgaa gctaggagtt 128461 catgaccagc ttgggcaaca tagcaagacc tcatctcaaa aaaaaaaacc caccacatat 128521 tatatgactc catttatatg aaatgtccag aataggccag cctatggaga cagaaagtgg 128581 attgatggtt gccaatgctg aagaaggata gggcaatgac tgataatagg tgcaagggtt 128641 tctttatggg aggatacaag cgttctagag ttggattgtg ttgatggctg cacaactctg 128701 tgaatgtgct ggagatcact gaattgtaca ctttgcatgg gtggattttt tagtatatga 128761 attctacctc aataaagctg tttagagttc ttattttttt aaagaagaaa accctccacc 128821 tatgccatat ttttcagtga gttccagaaa aagaatagat ggtttacatt caaggagaaa 128881 ttggtttctc ctccctttca tattcaaatg ctattagtgt aaccagagaa aggaaaggaa 128941 cttttatagg tttatcaaat atatacagcc aattctaaca aaatacagtt gtaaagtacc 129001 ggagaaagtt aaaattaaat ttgacatcaa tctgatccct ggagattact tcagttaatg 129061 gcttgtaaat tctaaatgta attgtatgca tgtctatgtt tgtgcagatg ccggctcatt 129121 gttccggctc ccgtttgtct ctctgctctc tccctttaag aaagcacttt attcattctc 129181 ttggattcct ctatttgata ttgaaataat ttcaaattta catgtcttgt tttaatctct 129241 gtcccaagag acactagaag gagcagaagc agaagggaga agtggctgag actgcagtga 129301 ttactgaagg agggaggccg aaagtggaga cagttctttc tcaggaaaca gaatagcaag 129361 tcacctgctg agacttgggg gttggaatgc tgaagtgggg ctaaggagac agatgcagat 129421 tggaaggtag caaatggctg aggaccagga gagagagtga ttgttcaaac attggctgga 129481 agattatctt ccatcatctg caaccacctg taattttgtt cccactaact cccaaggagt 129541 ctccagacca aggctcacat ggggatgaat gaaggcctct acttcctttt tcataaaggg 129601 aggcttcatt tgcatatgtt cacccagttt gtagcatcat ccacagtttc caataggcat 129661 gcatgatctc atgtgggcag acagtgtgtt tctgtggttg actagaggaa gccagggaga 129721 catttgctac tgagcatggc tagtatctgt gtgtgtgaga gtgagtgtgt gtgtgtgtgt 129781 gtgagagaaa gagagagagt gtgtgtgtat gaatttcgtt tcaaaatcca tatgacacct EPI-109

129841 acagatgtta tcatgttgtc tattgagata aagaattttg gagttctttt aatcacaaat 129901 atggaaaatg ttataaaacc ttcccaaagg caaatctgaa cactaagatg tgttgtgatg 129961 ccaaagactc tgctttgaag gagaaaagga aacaccttca cctaccatca gtgttctgca 130021 agacagtgac atctttcaca aatgcaacgt ctccagcatt ctcagccagg cacctaaaat 130081 gttccagaaa atatacacat aattacagaa gagaaactag tggggctttc ataaatattt 130141 gtaatatgca ttccaaaaac tgaaatatgg aagtaaacat ctaaaagaca actatttcta 130201 ggaatttact gtttacagcg gcagattgaa cacaggtgta cctgccctcc ttttaaaacc 130261 ctatataaaa gacattacaa aaccaagaaa tctaaagata tgcgacccag gaaacaggca 130321 atctaacatg aagtaagaca aaggaaagca ccaaaataat ggtcaacagg acccccagga 130381 ccacagatgt gcaggcggcc tacacagcaa ccagtccaaa ctgcagcagg aagatggatg 130441 ccttctggag cagcacttcc aagtaaatga tgaaactgtg atagcaccca gagagagaga 130501 gagagagaga gagagagaga gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 130561 gtgtgtgtgt atgcatgttg ttaggagatt tacattactg gcagacagtt tggggatgag 130621 atagtgatgt gtttttttaa gtgcagaaaa ttaagcaaat aagaaaagac atttatgaac 130681 tccagagtaa acaaaaagtt tgtacaataa gggaaatata atatgagaat aacgcttaca 130741 cagtcataag tactgaata^'t gacattagcg tgttgggtgc tgaagagagt tgaagtctgt 130801 ggttgtgtgg tggaaaaggt gctgggggca gtgtgagagg ctagatcttc ttctatacta

130861 cagagtcagc agaaagttaa aaattaagaa ccagcattat aaggatgata gaaataaagg

130921 ggtatgacac tggtttcagc ttttaatgat tttgctataa atttccccaa tctagattct

130981 agatataatt taaacaaaag acaagggatt ttcttccagt ataattagga atattaaaat

131041 gtgggtgttt ccagtgaact aataccttgc tgcaggtctg aaaaaaaaaa aaagaggagc

131101 acatgcttct ttcgggctct tatgagacat gtgttcagca tttctgagta gaatcacatt

131161 tccatttgca aatccttagt cccttaaaga tatttttata cattcacaaa acattttttt

131221 ttgttttggg tcttttttta tgagccactt atatagcaaa agctactttt ctgtcattcc

131281 attactggaa caaggctgtt gaatttatat taaaaagttc agacaccctc agacacatga

131341 cgccatctgg tcgtgaaatg tactcttggc aaatggagga aaaggaacag gggaagatcc

131401 tctctgcacc cttcacactg gtaaatagtg cccctgagaa gcaacacccg gatgaatggt

131461 gctgtaaaac gtggggtgtg gttacaagtc actaagtggt tataacttat gaattctgaa

131521 aacttgtttt ttggcttatt tttcacttcg ttactggaga ataacactgc aattctgcca

131581 tctctttgcc atttctaagg ccaaagtcag agaaaaaggg aaacctaagc catagtcatg

131641 acctaggtga gaagaaaagg ggcggcgatg ggaaagagaa ttcttcccca taaatggaat

131701 tgtaggaagc acttaggata ccacactcta cccatttgat tttcaggacg aggctattga

131761 ggcctactgc tgttgatctt ggctcaaagc cacagggaga agcactgcgg agctgaggtc

131821 agacagccct ggtgccagcc tccactctct ggggcggtgg gtgtggtggg gacagccctc

131881 actggggcca cccatgagct gacccacagg atgaccccca ctctgctgtg acaggtcaca

131941 tctggctcct tagaactgca atgctgacat gctgagggat gaggtaagtc cccatcctga

132001 tggagctcag tcacagactc accggaaagc cccagtgtag ccgtagtatc tctcgttgct

132061 gttgggcacg cacttattct caccctgctc gtcgccaata cacagagcac agagattaga

132121 tctcgggtca gacccagggg cacagctttg actgaaatat tcatctggag agaaggaaca

132181 cggggagtca gctcttcaaa cctgagtcca cacaagcaac ctttacctaa cagccgatgc

132241 agggtggttt cagttcatta gacttcccag gacagcaatc tagatagaac acactcacca

132301 tcacaaagca acatgttgtc accaacatag gacccaccag aaaagcttca ttcagactgt

132361 aggcacagat ggacacccaa ctaaggctgg ggatgagagc tgtggctgcc tggagggtcc

132421 cgtcatcaca gccttgagct ggggactcag ctcatgaccg tgatggctgt gtgcagcaga

132481 gcctgtgagt tgcctagtcc aggatctgat tttgttttta tcagtaatgg aaaccctgct

132541 ttgtatctgg gtgcttggcc ctttggtata aagactagac ttatcagact ccctggggct

132601 catatggcca tatgggtagc tataggccag tgaaatatca gcaggagtgt tgggcgccag

132661 cttctcagaa acatccttga aagacaattg gtacatgcct tttgcccttt cttctccttc

132721 tctttcttca tcctgcacat agaatgcaga agcagggact ggacttagag atgcaatgtg

132781 ggccatgagg tgaccttgag catgaaagcc acacaaatgg cagagtagcc aaatgattaa

132841 agcccaggtt ccagacccca tattgtcttc ataccagccc taggcaaacc acctctggac

132901 tacatgacac agaaattaac ttctgtcttg tttaagcctc tactatttca ggagttttct

132961 gttccttgca gctgaacctg atctgaattc gttcattgtg tgatttaacc caagaaagaa

133021 taaacaaagg tgacaagaaa gctctgcccc actgagcaaa cgtcacccat tatcagactc

133081 ccactgctgc tggaagagcc acactatgtg tcaacctcag gaaaagctgg gagttcccat

133141 tccatcctgg cagtttccct acagctcaga ggctgccatg gagctggtga ggagcagagc

133201 cacgtgaaag ctgcctgccc cggccaggat caaaaaccca tgcagtggag cccctgccct

133261 aggagacgcc catacaagaa gggagtcaca ttgaggatgt gctacacacc atgccacggg

133321 gcccacagca ggcagggtgt ggctgatgct gactaggatg agtgtggggt gtggtgggga

133381 gagaaaactg cagaagcagg tggagccagg ctcttgaggt cttattcagg ctccgttgca

133441 gtgtagagta agcgtcagtt ttgcttagta acaggagtca cctttcatga ggcaggcaga

133501 catctttccc caagctggga agccagagtt taagaggaat ttaggtctgg agctccaaga

133561 ggtaaaaagc atttgcacat cttggaactt gcatttattc ttagggtgca gcgaaatagg

133621 cagatattcc aatctttaat cttggggtgg ggtgaatggg gcatgggaag tgctgtgcag

133681' ggaaaccccc agtgcaccca cgcctccagg gggcagccac agggagaatt tccttatgct

133741 ggaagaggcc tgcaggccac tatcagcctg caaatcccct cccctccctt ccctaaggtt

133801 ccacagcaca atatgcctac cctccagggt ggcccaccca ccgcaccttt ggaactcctt

133861 accaaatttg caggagcccg tctggttgaa gagcaggccc atggggatat tccagcctgc

133921 agtcctgtcc acggcggtgt ggcaggactt cttgcctttc acagagttcc aggtaaggct

133981 agtgtctgat ctcctaacca ccgccacagc aagatatcct ggcataacag atgacagaaa

134041 aacaagtctt aacctccagg aggcctggca catggattcc agtggagctg tctacagccc

134101 aggccaaaac aggccaagaa gcaacaccag gcaatgattc cctcaaagaa ctggcctttt

134161 taggtagacc gagaaagcat aagctgctgc cttatgttaa ggtgagattg atgaaataaa

134221 acagtaagaa aagctgatta ttttagtgat tacaggggac tgtcttcaac cagccacaca EPI-109 881

134281 atgtccctga gttacaaacc agcaatgcat ctctcagtgt aagcttctac agcaacaaac 134341 actataaaca acaagagaga ccccaacagt gcataaatca ccaaccacag tgtgcatcag 134401 gcaagagcac caacatccag ccagctaacg gctgtgtggg tacaggggca catgtcccca 134461 gggactgccc tgagctgagt ctgaacccac cctgcactgg ttgaactcaa catggttgcc 134521 gttgtcctcc tgagagaatg catctgacag acacccacca agggcaagtc ttttctgaaa 134581 ctgagcaagc accagctctg gtgggcagga ggagtggtgc acagagcact gggacacgag 134641 tcccaggtca cgaggacccg gggtcaagac caggatctac cacagtatta cctatggctg 134701 tgagtgagat cctgggcact tggggactct cggtgccact gtttcctcat ccccatgagg 134761 tggggaagta gcacccccca ttccatgacc atgacaaaat gagggactat atggatgttc 134821 tttgccaagt gtgaaggtca atataaacat taattagaac tattcctctg tgaattattt 134881 gcacccttaa aattattgct cctagaagcc ctatagcttc tagggctgca attctttctg 134941 ttttttttac agttcctgcc acttcctctt ccagcaacaa gaacttatcc ttgaccctga 135001 aagtggctaa tgccaactca ccttccacag gtctatccac acagttagga tcagggtcac 135061 tgctttgttg ggattctgaa agaataaaga caagccagac atcattatcc attcagatgt 135121 agtgagaagc cacaaactct taaatctcaa tgatgcagaa tcaaatccaa agagaccgtc 135181 ccagcagttc catgcaggag aaatgcgtct atatgttcaa caaaagacat ggcacagaga 135241 ttcacagctg cattattcac cacagccacc aactggaaac tactcaaatg cccatccaca 135301 ctcaaatgat gaataatcac agtagactca cacagcgacg agactgaaca gtctacaact 135361 acacacttag gtggatgaaa agcataacga tgagcaagag aaaccagaca taaaaaaaca 135421 catgctgtgt aattccttta acatgaagtt taaaacatag gcaaacttag atctgcgacc 135481 ttagaagcca ggagagaggc ttcccttgca ggagtaaggg ggcgggggac aggaggacat 135541 aaggggcttc tgaaacttgc agtgtttgtt ctgggcccga gagcatggac tgtacagtgt 135601 gtgaagtgcc atgagttgta catttatgtg cacttttctg tttgtatgtt ataattcact 135661 gagatcttct ggaaaattaa gaagataaaa ccaacctgtc ccttgttaat tctcaacaca 135721 ataggctttg tgggtaacac ggcccctttc atttcttctt tccctgattc tcccttttga 135781 atgtatctgt tcatcataat gtttcacctg cattcaccga atgggattac tcatagcccc 135841 actcccatga cccagaggga atataccaga ggatgctaac tccacttact gtagttctct 135901 gccaggacag gcaccaaacc acatttgcct gcagtgtaca catatcctcc atccaaactc 135961 atggcatcag cttctccttt ctgcaaagac agagcagatc tccagcacca cagtgaggct 136021 gcatcccgtc ctgcctgtct atatagctct ctgagagaat ggttttctgt caggtgacca 136081 gtgaaacagc agaaagagat ggactattca aactgagcag ccagaggaaa caccgtgtgc 136141 accactaatt ctctcccagc cctgcctact ttctgggctg tcaattcaac tggaaagacc 136201 aggcacaggt tgcactaatc ctctgtcctc tgagcaaaac cttttctgtg tccctggcac 136261 tttggggaca ccttcctgga gcagtctcac tgactgagga cacagatggg aacagctggc 136321 ctcatctaat ctgaactcat tagcactcca ctccaagcgc tacacagaag ttgtccaaca 136381 cataagctga agtcgtcata ttggcccacc accagaatga acaagtccag gctacaacac 136441 aggatcatgg actcatcagt agtatgaaac ttcctctttg acccagtaat atttttacaa 136501 ctatattaaa aatagagaag tggacaaaga tttctactca agaatgctca ccacagggtt 136561 attgataata gcaaagtaag ggacaaagag gaatgggggc atgactaaac tgagccatat 136621 tcacataaaa gatatcctgg aagcatgttt aaaaaatgtt ttcgtccgag tgctgtggct 136681 cacacccgta atcccagcac tttgggaggc cgaagcagga agattgcttg agcccaggag 136741 ttcgagacga gcctgggcaa caaagcgaga ccctgtcgct acaataataa taataataat 136801 tatgcaggtg tggtggcgta tgcctgtagc cccagctact tgggaagctg agatgggagg 136861 atcacttgag cccaagagtt ccaggctgca gtgagatgtg gtcgcaccac tgcactccag 136921 cctgggtgac agatcaagaa tctgtctctt aaaaaaaaaa aaattaatgc tttccaagag 136981 taaatattca tgtggaagaa tgcccattat acgctgttta gtgaaaaggg cttaaaaacg 137041 acatactgca acacttcatt attgttgcat gcatatctgc agatgtgcag agaaatactg 137101 gaatggagaa ttagccagac tttaaccatg tctgtccctc tgtgtgagat cacaggtggt 137161 ttggggggtt tgttgttgtt ttgttttaac ataatacctt tccatatttt ccaaattcct 137221 tataataatc ctgagttgtt cttataacca gaggagtggg aaacccacag taaactgctt 137281 tttgaaacta aaatgctttc tggccctgag cacacctctc caggcatccc tgcctcaccc 137341 aggcccccgt ggcctctttg actgttgact tcactttaag cagatgccca ggccctaggt 137401 cttccaccgg gcccaccgcc cgcccctgtg atggagctcc ctaccagcac cagggcgatg 137461 cagtcctctg tggtggaggc cgaggagcag gtcacgctgc cttcgctcaa gccactccac 137521 tggttacact tgcgcagctc ctgctcgccc accgcacacc acacgacccg cgcacgccgg 137581 gcagccactt cctcctcacc tgccagaggg aagaccgcag gtggctgggc aacctgagct 137641 ttgccaggtt gtccaacctc cccagagcca gggtcctgcc cagactctcc ctggaacagg 137701 agctacagta catgtgtgga catgtggacc cataccctct cctcctccac ttctcagctc 137761 caagcccctt cttcaggtcc acagagctcc ctgtgtttcc cacttctgtt cctttggaga 137821 agttccctgg cttctaatct atccattaat ctttagagtc aggaggcgcc tattgtctct 137881 gtctctgagg ataaacgctc catgacccag agaccagtga cagtcccaag agatggccta 137941 ggggaccttg agcccaaccc tgacttcccc taacgcctgc aatcaccacc aataactacg 138001 gtgcagcctc tgggttcccc cagactccca cccccagccc cccagtagag aaggagccat 138061 agctgagttc ccccaccatg gtgtccccaa ctaagttcaa ggtctgggcc tgggaagtgt 138121 gggtaaatcc aggcccccgg attcatccag gaggggtcct ggctatcttt gttcatgttc 138181 atgtttctca cttaatagga ggcaaactga tttttctgcc aggcctgggg agcctgacgt 138241 gcactgatca ggtggccaga ctattctttt agagacacct gacctaatcc acagaagaca 138301 ctcacacctg catcaaacct ccacgatgac cccacagtgt ctgggaaaag gagtgaccgc 138361 cacaaagtag ggccacctgc tgggaagtag aagaccacac caggcggacc tcaggaccct 138421 cctgggctca ctcacttttc ctcaagttct ggatggcagt gaagtagccg gagccaaggt 138481 acagcccaga atctatcctc gggggcaccc tcgaaaaccc aatggcagag tccttgaaca 138541 gcagatcttt ctgcccacta ggggagccaa agagctggaa tttcggtgac ttgtcctttc 138601 caaacttttc ctaattaaga aaaaatagaa ttatggtgtc aatggtaaat agggaggaaa 138661 caaaaaaatg atgttaaaaa agagtatctg gagctttggg atcattctaa ctgagagcag 138721 gagcctcggt tgagaccctc ctgcagaggg acttgtgcca tctcggagac ccaagctcag EPI-109 882

138781 ctatggctca ttctttgaag agttgctgag gtccaagcac cttagggccc tgagaagatt 138841 gcatcgacca ccccctgctt ctgctcccat cataagacgc tgtcagcccg tgtgacagaa 138901 gagtttcatt gcttctgctg tccacagtac agcctgggca agcagcccaa tgcattagtg 138961 tgctatcctg cagcaaagct acaggacttc tggagtggca gaagtcaggg aagtaagaaa 139021 ccttgctccc tgccccccat atccaagcaa gtggggagga ccgtgggtga agatacctgt 139081 gcctggcgga gaagattcca gatggcatcc tccttgccat tcacacttcg tgccacaacg 139141 gcatgagaag ggacccgggc cagatggcag tctttgaact tgtccactgg cttccgagtg 139201 ttgtctgggc agagtaactc atactcgtcc ctttcagcct cgtctgacag gtcctctgca 139261 gggaaggtga ggtgggaggg agtctagata agccgactcc agcagtaacc tcgagctata 139321 gttccccttc tccctataga attttgagct tggggagata gctgacaaaa ctgagggtca 139381 gaaaggcagg ggtttgctcc agaacactca gaaaggtaaa ggtagtgccc caaaagcctc 139441 agggggcagc cgaggtgtga tcctcatcct aaatcactta ggccaccctg gggttcccgt 139501 gcagctgctg cctggcaggc cagagaggcc aaaccagacc cgtctgtttc tgcggcatct 139561 ctgcctggaa aagtcacttt gcagagacaa gctcaggggg ccaccaaggg ttgctccctt 139621 actcacatct ctgggaagaa taaaaatgac aaaaatgtta acaaggcagg gaataaggca 139681 ggaaggtgag acactttcca acactgagta tatcaaaaga aggggaagaa tggttttatg 139741 aatgagttca ggcaaatgtg gaatatcata tataagttgc ttcagaatgt gtaaagtgaa 139801 aaaaatcttg cccgagtcat tttatgagat tagtacaacc ttgatgtcaa aatcagaaaa 139861 agtataggag ggaagaatta aaagtttatt ttacttacga acataaatgc aaaatttgta 139921 aataacgtac taactaactc aatctcacag agtatttaaa aagctaatag attggaatga 139981 aggtttacca gtgtattcca ttaacaaaag aatggctgaa catcaaaaaa actaaagtaa 140041 tctgcattta atggcagaaa accatgagat cgtcttcatc ttaatagatg cagaacgatt 140101 gtttatgtgt tcaacatcta tttgtgtgtg gttttttttt cagcctcaga aaaatagtaa 140161 tagatagaat cggtaaagtt tttttgtttg ttttgagacg gagtctcact ctgttgccca 140221 gcctggaatg cagtggtgcg atctcagctc actgcatcct ccatctcctg gagtcaagag 140281 attctcttgc ctcagcctcc caagtagctg ggaccacaag cgcacgccac caggcccagc 140341 taatttttgt atttttaata gagatggggt ttcaccatgt tggccaggct ggtctcgaac 140401 tcctgacctc atgtgatcca cccgcctcag tctcccaaag tgctgggatt acaggggtga 140461 gacaccacgc ctggccataa gttattggct tgataaatgc cattaatcta cagcaaaaac 140521 cttactaaaa gaagaaaatg tagacattca ccgcaaaatc aggaacaagg caaggatgcc 140581 cactgttaca atgccagcac aattctagat atccagatca cacaatttac aaaagaaatg 140641 tgagatataa acactggaag gaaaaagaca cactcttatt taaaaagatg atatcgtcat 140701 ctacaaaaaa ccaatgaaac caacagaaac taataaaact actcagagga gtaacaagtt 140761 ataagagcaa cctacaaaaa tcagatgtta tcctcattaa caataaccaa atagaaacca 140821 atatggacta taagatgtta caatagcaac taaaaccatt aagtagctaa taattagcct 140881 cccacaaaga cacatcagac ccacaaagga aaaattttag ttctatcaaa gaaactaaaa 140941 agaggtgtga tcaaatgggg gagatttagc atcaccatgg actggacaac ttaatgttat 141001 aaatatgctg atttttcatg gaacaattta aattcagtac aattcgaatc aaaattaaag 141061 tatgattttt tccagaaatt caacaaaata attctgaagt tttagctgag tatatttgaa 141121 aaggaataat aaagtgagag gggagaggga gctctctctc attctctctc tcttcctctc 141181 actggctctc tctctttctc tccaccagat agtaagaccc attggtaagc cacagtaaca 141241 aaagcagaaa aaatgcaaat acaccaatga aataaaatag ctcagaaact ggtccacttg 141301 gatatataca aacttggtgt agaattggct tcacatatgg cagaaaaaat atactttttt 141361 tattgtaagg taaattgcct cactgtaaag gggataaaat gctaaagcca aatctatatc 141421 tgactttcta ggtagagcac atataaatag atgaggaagg ggatcttcaa atcttatttt 141481 aggaaataat tatgatttgg gtgtgaagaa gggcatcttt gaaatatctc aaaactacaa 141541 accaacaagg tgaggcttgt ggatttgacc ttatcaatat caaggatttt tgatcaacag 141601 agactaccgt tgtcagattt ttgactgaga agaggtttta ctaaagttta aaatcagcaa 141661 tagtttgata cctagataga aggaacttct gtccttgaat caaaatcatg cagaaacaag 141721 gtgtgaaact caatttaaaa agtagtcaaa tgtcacaaaa taagaaaggg aagcccaaac 141781 ggctagcaaa tatgttgaaa tgatcaaact caccagctgt cagagaaatg aaaattaaaa 141841 ataaaacgaa ctatctattg cattacaacc atcattcgga caaaaagtat gaaagtcaaa 141901 aatacttcta actgaagttg tggggaaatt agaacacttg cagagtgtca ttccagacag 141961 cagcttggtg atcctgggtg catgtggggt ctgtctctgg tggccctggg tgcatgtgga 142021 ggtctgtttc tggtggcctc tgatgaatgc ggggtctgtc tctgatggtc ctaggtgaat 142081 gtgggtgttg tctctttctc tggtggtcct gggtggatgt ggggtgtgtc tctgatggtc 142141 ctgagtgaat gtgggtgtct gtcactttct ctagtggccc tgggtggaat atagtagccc 142201 tgtctctatt ggtcttgcat gaaatgtagt gagcttatgt ccactagtcc tgggtgcagt 142261 gtgtttagcc tctacatact catcaactgc tttattataa gtccaggagg gacgctgtcc 142321 agcaggtaag taaggaacac aggtgaaggt atcagtcgtg tggctgcatg tggtagagga 142381 aaagagagca caacctctgt ccatcactat ggtgacagag aagtaaaagg tggatgtatt 142441 ccacggaaca ctcctcaact gttaggaccc ctgagctaga catgtataca acaataccga 142501 taaacctcta aaacaaaatg ctgagcagaa aacccaagta gcaggatttc taatgctcac 142561 taaaacctct atgaacccag aaaccggaaa cacaaaccag cacaatctgt tctgcatgag 142621 cacatgtgtc ttggaggact ggaggacgca ttgccaagca cctaggcatg ggtgtctatg 142681 aggggaagag aaaggcagta ggcacaggag gtttgaagaa aactgatcat ttaaaatatg 142741 aaagatcata aaatcagagc tgtgccctgt aggaatcttg aaaatggtct gccatgaact 142801 taggaatcta attagctcaa aggtcagagt catgatcaag taagataaaa ggggtcagta 142861 cccacggctc attaccctgc tcttaccaaa cactgtgctc tctctgataa aagccacgtc 142921 tccagccccg tctctcagac acctgtgaaa agagaaacca tcaggggtaa gcacaggcag 142981 ccctccccag cccctccctg tggaacagta gccctggcac tcagcatcta tgggtttcta 143041 ctccctgcag ggcagggctc tgaagctt

(2) INFORMATION FOR SEQ ID NO: 2673: (i) SEQUENCE CHARACTERISTICS: EPI-109 883

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2673

1 gagctcagaa attcaaαacc agcctgggca aggtagagag acccccatgt ctacaaaaaa

61 taaaaaatga ttagtcaggt gtggtggccc gcacctgtag ttccagctac tcaggacgct

121 gaggtgggag aatgactcga gcccgtgagt tgaggctgca gtgagccgag atcacaccac

181 tccagcctag gcaagagtga gaccctctct caaaaaaaaa aaaaaaaaaa aaaaaaaaag

241 aaccatcaaa atgttttgca cagcagtcac gccattttac atttctgcca gcaatgtgca

301 ccaggcttcc agtttcttca catcttcact aactcttatt tcctttgctt taaactctaa

361 ccatcaaagt aggtgtaaag ggtatctcac tgtggtttga tttgcatttc tctaatgact

421 aatagtgtta agtatcattt catgtgcatg ttggccattt atatgtcatt ggagaaatgt

481 ctactcaaac cgtttgctca tttagaaact taggtaggtt ggtctgagtg cagtggtgtt

541 taaaactaat ttttttttga gacaaagtct cactctgtcg cccaggctgg aatgcaatgg

601 tgagatcttg gctcactaca acctccatct cctgggttca agcaattctt ctgcctcagc

661 ctctcaagta gctgggatta caggcatgcg ccaccacgcc tggctaattt ttgtattttt

721 ggtagagacg ggggtttctc catgttggcc aggctggtct cgaactcttg acctcaggtg

781 atccacctgc ctcggcctcc acagggctag gattagaggt gtgagccacc gcaccaggcc

841 gtttaaaact aatggagcac aaccagttac caatatcttt gttccttctc cactccctct

901 gcttcaactt gactagccta aaataaataa atttaaaaaa ctgggcacag tggctcacac

961 ctgtaatccc agcactttgg gaggccgagg caggaggatt acttgagcat aggagttcaa

1021 gatcagcctg ggcaactagt gaaaaaccat ctcaaaaaag aaaaattagc caggcatggt

1081 ggcatgcacc tgtggtttca gctacttaga gcagaggtgg aggatcgctt gattctggag

1141 ttcaaggttg cattgagctg tgatcgcgcc agtgcactct cgcttgggtg acagagtaag

1201 accttgtctc aaaaaattta aaacaaaaca aaaaaaactg gttatttgtc tttttattgg

1261 tgaattataa gagttttaaa aaatatattc tggaaacaaa tcccttatta gagatatgat

1321 ttgcaaatat tttctccaat tttttttttt tttaaagaca aagtttcact ttgtcgccca

1381 ggctggtctt gattcctggc ttcaagagat gctcttacct ccacctcctg aagcccaaag

1441 ggctggaatt acagccagtg agcctgcacc cagcctccaa ttctttagat tttacatttt

1501 agaaccaaaa tgggttaaat acactgttct gtaatctgct cttttcttta atagtagttc

1561 atgtacatct ttcaaggtcc agagaaagct ctcactttct ccccgtttta tttttccttc

1621 cctcattctt tttcactgct gcatagcatt ccattgtaat tttgccactg tttattagac

1681 cagtcctctg ctgagcttta cagagccctt agttggatgt tagtgagaac catgacagca

1741 gtgagactgt catctccctg acatgctgtc agcttttgga tgatgtgaaa atgcaagcag

1801 gcacaggaaa tgtctctaac ttgcttacac ttcctccctg aaccctgcgg tttcacaact

1861 cctgcaggca cacctccctc cccgcctgcc agtgtcacca gcctgttgcc tctgtgagaa

1921 agtaccactg taagaggcca aagggcatga tcattttcct ctttcaccct gtctaggttg

1981 ccagcaaatc ccacgggcct cctgacgctg cccctggggc cacaggtccc tcgagtgctg

2041 gaaggatgaa ggattcctgc atcactgtga tggccatggc gctgctgtct gggttctttt

2101 tcttcggtag gcaagggagg aggcagggga agggacatgt gtctgtgacc agagaaactg

2161 cagggcttgg tgcagctgga gtaaacaagg agctgccccc taaaagtggg attggcctta

2221 gggatatggg gccccaggga tcttggaagg agaaagggga gagcggggaa ataaaag

(2) INFORMATION FOR SEQ ID NO: 2674: (i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2674

1 gatcttggct cactacaacc tccatctggt gggttcaagc aattcttctg cctcagcctc 61 tcaagtagct gggattacag gcatgcgcca ccacgcccgg ctaatttttg tatttttggt 121 agagacgggg gtttctccat gttggccagg ctggtctcga actcttgacc tcaggtgatc 181 cacctgcctc ggcctcccac aggctaggat tagaggtgtg agccaccgca ccaggccgtt 241 taaaactaat ggagcacaac cagttaccaa tatctttgtt ccttctccac tccctctgct 301 tcacttgact agcctaaaat aaataaattt aaaaaactgg gcacagtggc tcacacctgt 361 aatcccagca ctttgggagg ccgaggcagg aggattactt gagcatagga gttcaagatc 421 agcctgggca acatagtgaa aaaccatctc aaaaaagaaa aaattagcca ggcatggtgg 481 catgcacctg tggtttcagc tacttaggag cagaggtggg aggatcgctt gattctggga 541 gttcaaggtt gcattgagct gtgatcgcgc cagtgcactc tcgcttgggt gacagagcaa 601 gaccttgtct caaaaaattt aaaacaaaac aaaaaaaact ggttatttgt ctttttattg 661 ttgaattata agagttttaa aaaatatatt ctggaaacaa atcccttatt agagatatga 721 tttgcaaata ttttctccaa tttttttttt tttaaagaca aagtttcact ttggtgccca 781 ggctggtctt cattcctggc ttcaagagat gctcttacct ccacctcctg aagccccaaa 841 gggctggaat tacagccagt gagccactgc acccagcctc caattcttta gattttacat 901 tttagaacca aaatgggtta aatacactgt tctgtaatct gctcttttct ttaatagtag 961 ttcatgtaca tctttcaagg tccagagaaa gctctcactt tctccccgtt ttatttttcc 1021 ttccctcatt ctttttcact gctgcatagc attccattgt aattttgcca ctgtttatta EPI-109 884

1081 gaccagtcct ctgctgagct ttacagagcc cttagttggg atgttagtga gaaaccatga

1141 cagcagtgga gactgtcatc tccctgacat gctgtcagct tttggatgat gtgaaaatgc

1201 aagcaggcac aggaaatgtc tctctaactt gcttacactt cctccctgaa ccctgcggtt

1261 tcacaactcc tgcaggcaca cctccctccc cgcctgccag tgtcaccagc ctgttgcctc

1321 tgtgagaaag taccactgta agaggccaaa gggcatgatc attttcctct ttcaccctgt

1381 ctaggttgcc agcaaatccc acgggcctcc tgacgctgcc cctggggcca caggtccctc

1441 gagtgctgga aggatgaagg attcctgcat cactgtgatg gccatggcgc tgctgtctgg

1501 gttctttttc ttcggtaggc

(2) INFORMATION FOR SEQ ID NO:2675: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2675

1 cagggcagac tggtagcaaa gcccccacgc ccagccagga gcaccgccgc ggactccagc

61 acaccgaggg acatgctggg cctgcgcccc ccactgctcg ccctggtggg gctgctctcc

121 ctcgggtgcg tcctctctca ggagtgcacg aagttcaagg tcagcagctg ccgggaatgc

181 atcgagtcgg ggcccggctg cacctggtgc cagaagctga acttcacagg gccgggggat

241 cctgactcca ttcgctgcga cacccggcca cagctgctca tgaggggctg tgcggctgac

301 gacatcatgg accccacaag cctcgctgaa acccaggaag accacaatgg gggccagaag

361 cagctgtccc cacaaaaagt gacgctttac ctgcgaccag gccaggcagc agcgttcaac

421 gtgaccttcc ggcgggccaa gggctacccc atcgacctgt actatctgat ggacctctcc

481 tactccatgc ttgatgacct caggaatgtc aagaagctag gtggcgacct gctccgggcc

541 ctcaacgaga tcaccgagtc cggccgcatt ggcttcgggt ccttcgtgga caagaccgtg

601 ctgccgttcg tgaacacgca ccctgataag ctgcgaaacc catgccccaa caaggagaaa

661 gagtgccagc ccccgtttgc cttcaggcac gtgctgaagc tgaccaacaa ctccaaccag

721 tttcagaccg aggtcgggaa gcagctgatt tccggaaacc tggatgcacc cgagggtggg

781 ctggacgcca tgatgcaggt cgccgcctgc ccggaggaaa tcggctggcg caacgtcacg

841 cggctgctgg tgtttgccac tgatgacggc ttccatttcg cgggcgacgg aaagctgggc

901 gccatcctga cccccaacga cggccgctgt cacctggagg acaacttgta caagaggagc 61 aacgaattcg actacccatc ggtgggccag ctggcgcaca agctggctga aaacaacatc

1021 cagcccatct tcgcggtgac cagtaggatg gtgaagacct acgagaaact caccgagatc

1081 atccccaagt cagccgtggg ggagctgtct gaggactcca gcaatgtggt ccatctcatt

1141 aagaatgctt acaataaact ctcctccagg gtcttcctgg atcacaacgc cctccccgac

1201 accctgaaag tcacctacga ctccttctgc agcaatggag tgacgcacag gaaccagccc

1261 agaggtgact gtgatggcgt gcagatcaat gtcccgatca ccttccaggt gaaggtcacg

1321 gccacagagt gcatccagga gcagtcgttt gtcatccggg cgctgggctt cacggacata

1381 gtgaccgtgc aggttcttcc ccagtgtgag tgccggtgcc gggaccagag cagagaccgc

1441 agcctctgcc atggcaaggg cttcttggag tgcggcatct gcaggtgtga cactggctac

1501 attgggaaaa actgtgagtg ccagacacag ggccggagca gccaggagct ggaaggaagc

1561 tgccggaagg acaacaactc catcatctgc tcagggctgg gggactgtgt ctgcgggcag

1621 tgcctgtgcc acaccagcga cgtccccggc aagctgatat acgggcagta ctgcgagtgt

1681 gacaccatca actgtgagcg ctacaacggc caggtctgcg gcggcccggg gagggggctc

1741 tgcttctgcg ggaagtgccg ctgccacccg ggctttgagg gctcagcgtg ccagtgcgag

1801 aggaccactg agggctgcct gaacccgcgg cgtgttgagt gtagtggtcg tggccggtgc

1861 cgctgcaacg tatgcgagtg ccattcaggc taccagctgc ctctgtgcca ggagtgcccc

1921 ggctgcccct caccctgtgg caagtacatc tcctgcgccg agtgcctgaa gttcgaaaag

1981 ggcccctttg ggaagaactg cagcgcggcg tgtccgggcc tgcagctgtc gaacaacccc

2041 gtgaagggca ggacctgcaa ggagagggac tcagagggct gctgggtggc ctacacgctg

2101 gagcagcagg acgggatgga ccgctacctc atctatgtgg atgagagccg agagtgtgtg

2161 gcaggcccca acatcgccgc catcgtcggg ggcaccgtgg caggcatcgt gctgatcggc

2221 attctcctgc tggtcatctg gaaggctctg atccacctga gcgacctccg ggagtacagg

2281 cgctttgaga aggagaagct caagtcccag tggaacaatg ataatcccct tttcaagagc

2341 gccaccacga cggtcatgaa ccccaagttt gctgagagtt aggagcactt ggtgaagaca

2401 aggccgtcag gacccaccat gtctgcccca tcacgcggcc gagacatggc ttggccacag

2461 ctcttgagga tgtcaccaat taaccagaaa tccagttatt ttccgccctc aaaatgacag

2521 ccatggccgg ccggtgcttc tgggggctcg tcggggggac agctccactc tgactggcac

2581 agtctttgca tggagacttg aggagggctt gaggttggtg aggttaggtg cgtgtttcct

2641 gtgcaagtca ggacatcagt ctgattaaag gtggtgccaa tttatttaca tttaaacttg

2701 tcagggtata aaatgacatc ccattaatta tattgttaat caatcacgtg tatagaaaaa

2761 aaaataaaac ttcaat

(2) INFORMATION FOR SEQ ID NO:2676: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single EPI-109 885

(D) TOPOLOGY: linear ^■ (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2676

1 ctcgccctgg tggggctgct ctccctcggg tgcgtcctct ctcaggagtg cacgaagttc

61 aaggtcagca gctgccggga atgcatcgag tcggggcccg gctgcacctg gtgccagaag

121 ctgaacttca cagggccggg ggatcctgac tccattcgct gcgacacccg gccacagctg 181 ctcatgaggg gctgtgcggc tgacgacatc atggacccca caagcctcgc tgaaacccag

241 gaagaccaca atgggggcca gaagcagctg tccccacaaa aagtgacgct ttacctgcga

301 ccaggccagg cagcagcgtt caacgtgacc ttccggcggg ccaagggcta ccccatcgac

361 ctgtactatc tgatggacct ctcctactcc atgcttgatg acctcaggaa tgtcaagaag

421 ctaggtggcg acctgctccg ggccctcaac gagatcaccg agtccggccg cattggcttc

481 gggtccttcg tggacaagac cgtgctgccg ttcgtgaaca cgcaccctga taagctgcga

541 aacccatgcc ccaacaagga gaaagagtgc ccgcccccgt ttgccttcag gcacgtgctg

601 aagctgacca acaactccaa ccagtttcag accgaggtcg ggaagcagct gatttccgga

661 aacctggatg cacccgaggg tgggctggac gccatgatgc aggtcgccgc ctgcccggag

721 gaaatcggct ggcgcaacgt cacgcggctg ctggtgtttg ccactgatga cggcttccat

781 ttcgcgggcg acggaaagct gggcgccatc ctgaccccca acgacggccg ctgtcacctg

841 gaggacaact tgtacaagag gagcaacgaa ttcgactacc catcggtggg ccagctggcg

901 cacaagctgg ctgaaaacaa catccagccc atcttcgcgg tgaccagtag gatggtgaag

961 acctacgaga aactcaccga gatcatcccc aagtcagccg tgggggagct gtctgaggac

1021 tccagcaatg tggtccatct cattaagaat gcttacaata aactctcctc cagggtcttc

1081 ctggatcaca acgccctccc cgacaccctg aaagtcacct acgactcctt ctgcagcaat

1141 ggagtgacgc acaggaacca gcccagaggt gactgtgatg gcgtgcagat caatgtcccg

1201 atcaccttcc aggtgaaggt cacggccaca gagtgcatcc aggagcagtc gtttgtcatc

1261 cgggcgctgg gcttcacgga catagtgacc gtgcaggtcc ttccccagtg tgagtgccgg

1321 tgccgggacc agagcagaga ccgcagcctc tgccatggca agggcttctt ggagtgcggc

1381 atctgcaggt gtgacactgg ctacattggg aaaaactgtg agtgccagac acagggccgg

1441 agcagccagg agctggaagg aagctgccgg aaggacaaca actccatcat ctgctcaggg

1501 ctgggggact gtgtctgcgg gcagtgcctg tgccacacca gcgacgtccc cggcaagctg

1561 atatacgggc agtactgcga gtgtgacacc atcaactgtg agcgctacaa cggccaggtc

1621 tgcggcggcc cggggagggg gctctgcttc tgcgggaagt gccgctgcca cccgggcttt

1681 gagggctcag cgtgccagtg cgagaggacc actgagggct gcctgaaccc gcggcgtgtt

1741 gagtgtagtg gtcgtggccg gtgccgctgc aacgtatgcg agtgccattc aggctaccag

1801 ctgcctctgt gccaggagtg ccccggctgc ccctcaccct gtggcaagta catctcctgc

1861 gccgagtgcc tgaagttcga aaagggcccc tttgggaaga actgcagcgc ggcgtgtccg

1921 ggcctgcagc tgtcgaacaa ccccgtgaag ggcaggacct gcaaggagag ggactcagag

1981 ggctgctggg tggcctacac gctggagcag caggacggga tggaccgcta cctcatctat

2041 gtggatgaga gccgagagtg tgtggcaggc cccaacatcg ccgccatcgt cgggggcacc

2101 gtggcaggca tcgtgctgat cggcattctc ctgctggtca tctggaaggc tctgatccac

2161 ctgagcgacc tccgggagta caggcgcttt gagaaggaga agctcaagtc ccagtggaac

2221 aatgataatc cccttttcaa gagcgccacc acgacggtca tgaaccccaa gtttgctgag

2281 agttaggagc a

(2) INFORMATION FOR SEQ ID NO: 2677: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2677

1 gagctcagaa attcaagacc agcctgggca aggtagagag acccccatgt ctacaaaaaa

61 taaaaaatga ttagtcaggt gtggtggccc gcacctgtag ttccagctac tcaggacgct

121 gaggtgggag aatgactcga gcccgtgagt tgaggctgca gtgagccgag atcacaccac

181 tccagcctag gcaagagtga gaccctctct caaaaaaaaa aaaaaaaaaa aaaaaaaaag

241 aaccatcaaa atgttttgca cagcagtcac gccattttac atttctgcca gcaatgtgca

301 ccaggcttcc agtttcttca catcttcact aactcttatt tcctttgctt taaactctaa

361 ccatcaaagt aggtgtaaag ggtatctcac tgtggtttga tttgcatttc tctaatgact

421 aatagtgtta agtatcattt catgtgcatg ttggccattt atatgtcatt ggagaaatgt

481 ctactcaaac cgtttgctca tttagaaact taggtaggtt ggtctgagtg cagtggtgtt

541 taaaactaat ttttttttga gacaaagtct cactctgtcg cccaggctgg aatgcaatgg

601 tgagatcttg gctcactaca acctccatct cctgggttca agcaattctt ctgcctcagc

661 ctctcaagta gctgggatta caggcatgcg ccaccacgcc tggctaattt ttgtattttt

721 ggtagagacg ggggtttctc catgttggcc aggctggtct cgaactcttg acctcaggtg

781 atccacctgc ctcggcctcc acagggctag gattagaggt gtgagccacc gcaccaggcc

841 gtttaaaact aatggagcac aaccagttac caatatcttt gttccttctc cactccctct

901 gcttcaactt gactagccta aaataaataa atttaaaaaa ctgggcacag tggctcacac

961 ctgtaatccc agcactttgg gaggccgagg caggaggatt acttgagcat aggagttcaa

1021 gatcagcctg ggcaactagt gaaaaaccat ctcaaaaaag aaaaattagc caggcatggt

1081 ggcatgcacc tgtggtttca gctacttaga gcagaggtgg aggatcgctt gattctggag

1141 ttcaaggttg cattgagctg tgatcgcgcc agtgcactct cgcttgggtg acagagtaag EPI-109 886

1201 accttgtctc aaaaaattta aaacaaaaca aaaaaaactg gttatttgtc tttttattgg

1261 tgaattataa gagttttaaa aaatatattc tggaaacaaa tcccttatta gagatatgat

1321 ttgcaaatat tttctccaat tttttttttt tttaaagaca aagtttcact ttgtcgccca

1381 ggctggtctt gattcctggc ttcaagagat gctcttacct ccacctcctg aagcccaaag

1441 ggctggaatt acagccagtg agcctgcacc cagcctccaa ttctttagat tttacatttt

1501 agaaccaaaa tgggttaaat acactgttct gtaatctgct cttttcttta atagtagttc

1561 atgtacatct ttcaaggtcc agagaaagct ctcactttct ccccgtttta tttttccttc

1621 cctcattctt tttcactgct gcatagcatt ccattgtaat tttgccactg tttattagac

1681 cagtcctctg ctgagcttta cagagccctt agttggatgt tagtgagaac catgacagca

1741 gtgagactgt catctccctg acatgctgtc agcttttgga tgatgtgaaa atgcaagcag

1801 gcacaggaaa tgtctctaac ttgcttacac ttcctccctg aaccctgcgg tttcacaact

1861 cctgcaggca cacctccctc cccgcctgcc agtgtcacca gcctgttgcc tctgtgagaa

1921 agtaccactg taagaggcca aagggcatga tcattttcct ctttcaccct gtctaggttg

1981 ccagcaaatc ccacgggcct cctgacgctg cccctggggc cacaggtccc tcgagtgctg

2041 gaaggatgaa ggattcctgc atcactgtga tggccatggc gctgctgtct gggttctttt

2101 tcttcggtag gcaagggagg aggcagggga agggacatgt gtctgtgacc agagaaactg

2161 cagggcttgg tgcagctgga gtaaacaagg agctgccccc taaaagtggg attggcctta

2221 gggatatggg gccccaggga tcttggaagg agaaagggga gagcggggaa ataaaag

1 gatcttggct cactacaacc tccatctggt gggttcaagc aattcttctg cctcagcctc

61 tcaagtagct gggattacag gcatgcgcca ccacgcccgg ctaatttttg tatttttggt

121 agagacgggg gtttctccat gttggccagg ctggtctcga actcttgacc tcaggtgatc

181 cacctgcctc ggcctcccac aggctaggat tagaggtgtg agccaccgca ccaggccgtt

241 taaaactaat ggagcacaac cagttaccaa tatctttgtt ccttctccac tccctctgct

301 tcacttgact agcctaaaat aaataaattt aaaaaactgg gcacagtggc tcacacctgt

361 aatcccagca ctttgggagg ccgaggcagg aggattactt gagcatagga gttcaagatc

421 agcctgggca acatagtgaa aaaccatctc aaaaaagaaa aaattagcca ggcatggtgg

481 catgcacctg tggtttcagc tacttaggag cagaggtggg aggatcgctt gattctggga

541 gttcaaggtt gcattgagct gtgatcgcgc cagtgcactc tcgcttgggt gacagagcaa

601 gaccttgtct caaaaaattt aaaacaaaac aaaaaaaact ggttatttgt ctttttattg

661 ttgaattata agagttttaa aaaatatatt ctggaaacaa atcccttatt agagatatga

721 tttgcaaata ttttctccaa tttttttttt tttaaagaca aagtttcact ttggtgccca

781 ggctggtctt cattcctggc ttcaagagat gctcttacct ccacctcctg aagccccaaa

841 gggctggaat tacagccagt gagccactgc acccagcctc caattcttta gattttacat

901 tttagaacca aaatgggtta aatacactgt tctgtaatct gctcttttct ttaatagtag

961 ttcatgtaca tctttcaagg tccagagaaa gctctcactt tctccccgtt ttatttttcc

1021 ttccctcatt ctttttcact gctgcatagc attccattgt aattttgcca ctgtttatta

1081 gaccagtcct ctgctgagct ttacagagcc cttagttggg atgttagtga gaaaccatga

1141 cagcagtgga gactgtcatc tccctgacat gctgtcagct tttggatgat gtgaaaatgc

1201 aagcaggcac aggaaatgtc tctctaactt gcttacactt cctccctgaa ccctgcggtt

1261 tcacaactcc tgcaggcaca cctccctccc cgcctgccag tgtcaccagc ctgttgcctc

1321 tgtgagaaag taccactgta agaggccaaa gggcatgatc attttcctct ttcaccctgt

1381 ctaggttgcc agcaaatccc acgggcctcc tgacgctgcc cctggggcca caggtccctc

1441 gagtgctgga aggatgaagg attcctgcat cactgtgatg gccatggcgc tgctgtctgg

1501 gttctttttc ttcggtaggc

1 cagggcagac tggtagcaaa gcccccacgc ccagccagga gcaccgccgc ggactccagc

61 acaccgaggg acatgctggg cctgcgcccc ccactgctcg ccctggtggg gctgctctcc

121 ctcgggtgcg tcctctctca ggagtgcacg aagttcaagg tcagcagctg ccgggaatgc

181 atcgagtcgg ggcccggctg cacctggtgc cagaagctga acttcacagg gccgggggat

241 cctgactcca ttcgctgcga cacccggcca cagctgctca tgaggggctg tgcggctgac

301 gacatcatgg accccacaag cctcgctgaa acccaggaag accacaatgg gggccagaag

361 cagctgtccc cacaaaaagt gacgctttac ctgcgaccag gccaggcagc agcgttcaac

421 gtgaccttcc ggcgggccaa gggctacccc atcgacctgt actatctgat ggacctctcc

481 tactccatgc ttgatgacct caggaatgtc aagaagctag gtggcgacct gctccgggcc

541 ctcaacgaga tcaccgagtc cggccgcatt ggcttcgggt ccttcgtgga caagaccgtg

601 ctgccgttcg tgaacacgca ccctgataag ctgcgaaacc catgccccaa caaggagaaa

661 gagtgccagc ccccgtttgc cttcaggcac gtgctgaagc tgaccaacaa ctccaaccag

721 tttcagaccg aggtcgggaa gcagctgatt tccggaaacc tggatgcacc cgagggtggg

781 ctggacgcca tgatgcaggt cgccgcctgc ccggaggaaa tcggctggcg caacgtcacg

841 cggctgctgg tgtttgccac tgatgacggc ttccatttcg cgggcgacgg aaagctgggc

901 gccatcctga cccccaacga cggccgctgt cacctggagg acaacttgta caagaggagc

961 aacgaattcg actacccatc ggtgggccag ctggcgcaca agctggctga aaacaacatc

1021 cagcccatct tcgcggtgac cagtaggatg gtgaagacct acgagaaact caccgagatc

1081 atccccaagt cagccgtggg ggagctgtct gaggactcca gcaatgtggt ccatctcatt

1141 aagaatgctt acaataaact ctcctccagg gtcttcctgg atcacaacgc cctccccgac

1201 accctgaaag tcacctacga ctccttctgc agcaatggag tgacgcacag gaaccagccc

1261 agaggtgact gtgatggcgt gcagatcaat gtcccgatca ccttccaggt gaaggtcacg

1321 gccacagagt gcatccagga gcagtcgttt gtcatccggg cgctgggctt cacggacata

1381 gtgaccgtgc aggttcttcc ccagtgtgag tgccggtgcc gggaccagag cagagaccgc EPI-109 887

1441 agcctctgcc atggcaaggg cttcttggag tgcggcatct gcaggtgtga cactggctac

1501 attgggaaaa actgtgagtg ccagacacag ggccggagca gccaggagct ggaaggaagc

1561 tgccggaagg acaacaactc catcatctgc tcagggctgg gggactgtgt ctgcgggcag

1621 tgcctgtgcc acaccagcga cgtccccggc aagctgatat acgggcagta ctgcgagtgt

1681 gacaccatca actgtgagcg ctacaacggc caggtctgcg gcggcccggg gagggggctc

1741 tgcttctgcg ggaagtgccg ctgccacccg ggctttgagg gctcagcgtg ccagtgcgag

1801 aggaccactg agggctgcct gaacccgcgg cgtgttgagt gtagtggtcg tggccggtgc

1861 cgctgcaacg tatgcgagtg ccattcaggc taccagctgc ctctgtgcca ggagtgcccc

1921 ggctgcccct caccctgtgg caagtacatc tcctgcgccg agtgcctgaa gttcgaaaag

1981 ggcccctttg ggaagaactg cagcgcggcg tgtccgggcc tgcagctgtc gaacaacccc

2041 gtgaagggca ggacctgcaa ggagagggac tcagagggct gctgggtggc ctacacgctg

2101 gagcagcagg acgggatgga ccgctacctc atctatgtgg atgagagccg agagtgtgtg

2161 gcaggcccca acatcgccgc catcgtcggg ggcaccgtgg caggcatcgt gctgatcggc

2221 attctcctgc tggtcatctg gaaggctctg atccacctga gcgacctccg ggagtacagg

2281 cgctttgaga aggagaagct caagtcccag tggaacaatg ataatcccct tttcaagagc

2341 gccaccacga cggtcatgaa ccccaagttt gctgagagtt aggagcactt ggtgaagaca

2401 aggccgtcag gacccaccat gtctgcccca tcacgcggcc gagacatggc ttggccacag

2461 ctcttgagga tgtcaccaat taaccagaaa tccagttatt ttccgccctc aaaatgacag

2521 ccatggccgg ccggtgcttc tgggggctcg tcggggggac agctccactc tgactggcac

2581 agtctttgca tggagacttg aggagggctt gaggttggtg aggttaggtg cgtgtttcct

2641 gtgcaagtca ggacatcagt ctgattaaag gtggtgccaa tttatttaca tttaaacttg

2701 tcagggtata aaatgacatc ccattaatta tattgttaat caatcacgtg tatagaaaaa

2761 aaaataaaac ttcaat

1 ctcgccctgg tggggctgct ctccctcggg tgcgtcctct ctcaggagtg cacgaagttc

61 aaggtcagca gctgccggga atgcatcgag tcggggcccg gctgcacctg gtgccagaag

121 ctgaacttca cagggccggg ggatcctgac tccattcgct gcgacacccg gccacagctg

181 ctcatgaggg gctgtgcggc tgacgacatc atggacccca caagcctcgc tgaaacccag

241 gaagaccaca atgggggcca gaagcagctg tccccacaaa aagtgacgct ttacctgcga

301 ccaggccagg cagcagcgtt caacgtgacc ttccggcggg ccaagggcta ccccatcgac

361 ctgtactatc tgatggacct ctcctactcc atgcttgatg acctcaggaa tgtcaagaag

421 ctaggtggcg acctgctccg ggccctcaac gagatcaccg agtccggccg cattggcttc

481 gggtccttcg tggacaagac cgtgctgccg ttcgtgaaca cgcaccctga taagctgcga

541 aacccatgcc ccaacaagga gaaagagtgc ccgcccccgt ttgccttcag gcacgtgctg

601 aagctgacca acaactccaa ccagtttcag accgaggtcg ggaagcagct gatttccgga

661 aacctggatg cacccgaggg tgggctggac gccatgatgc aggtcgccgc ctgcccggag

721 gaaatcggct ggcgcaacgt cacgcggctg ctggtgtttg ccactgatga cggcttccat

781 ttcgcgggcg acggaaagct gggcgccatc ctgaccccca acgacggccg ctgtcacctg

841 gaggacaact tgtacaagag gagcaacgaa ttcgactacc catcggtggg ccagctggcg

901 cacaagctgg ctgaaaacaa catccagccc atcttcgcgg tgaccagtag gatggtgaag

961 acctacgaga aactcaccga gatcatcccc aagtcagccg tgggggagct gtctgaggac

1021 tccagcaatg tggtccatct cattaagaat gcttacaata aactctcctc cagggtcttc

1081 ctggatcaca acgccctccc cgacaccctg aaagtcacct acgactcctt ctgcagcaat

1141 ggagtgacgc acaggaacca gcccagaggt gactgtgatg gcgtgcagat caatgtcccg

1201 atcaccttcc aggtgaaggt cacggccaca gagtgcatcc aggagcagtc gtttgtcatc

1261 cgggcgctgg gcttcacgga catagtgacc gtgcaggtcc ttccccagtg tgagtgccgg

1321 tgccgggacc agagcagaga ccgcagcctc tgccatggca agggcttctt ggagtgcggc

1381 atctgcaggt gtgacactgg ctacattggg aaaaactgtg agtgccagac acagggccgg

1441 agcagccagg agctggaagg aagctgccgg aaggacaaca actccatcat ctgctcaggg

1501 ctgggggact gtgtctgcgg gcagtgcctg tgccacacca gcgacgtccc cggcaagctg

1561 atatacgggc agtactgcga gtgtgacacc atcaactgtg agcgctacaa cggccaggtc

1621 tgcggcggcc cggggagggg gctctgcttc tgcgggaagt gccgctgcca cccgggcttt

1681 gagggctcag cgtgccagtg cgagaggacc actgagggct gcctgaaccc gcggcgtgtt

1741 gagtgtagtg gtcgtggccg gtgccgctgc aacgtatgcg agtgccattc aggctaccag

1801 ctgcctctgt gccaggagtg ccccggctgc ccctcaccct gtggcaagta catctcctgc

1861 gccgagtgcc tgaagttcga aaagggcccc tttgggaaga actgcagcgc ggcgtgtccg

1921 ggcctgcagc tgtcgaacaa ccccgtgaag ggcaggacct gcaaggagag ggactcagag

1981 ggctgctggg tggcctacac gctggagcag caggacggga tggaccgcta cctcatctat

2041 gtggatgaga gccgagagtg tgtggcaggc cccaacatcg ccgccatcgt cgggggcacc

2101 gtggcaggca tcgtgctgat cggcattctc ctgctggtca tctggaaggc tctgatccac

2161 ctgagcgacc tccgggagta caggcgcttt gagaaggaga agctcaagtc ccagtggaac

2221 aatgataatc cccttttcaa gagcgccacc acgacggtca tgaaccccaa gtttgctgag

2281 agttaggagc a

(2) INFORMATION FOR SEQ ID NO: 2678: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear EPI-109

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2678

1 ggaattccgg gcccggtctt tcctcccgcc gccgccggcc tggtcccggg gactggcctc

61 cacgtccgac tcgtccgagc tgaagcccag cagcactttg ctgccagccg cgggggcggc

121 ggaggcgccc ccgggccctc ccaggaggct ctctgggcca gaggccgaga ttcggcacag

181 gcccccagga gtccgtaagt aggagaggtc gcccgagacc ggccggaccc ccatccccgc

241 ggccgccgcc gccgctggtc ccgcggctgc gaccgtggcg gctgccgctg gaaaatgtct

301 caggagaggc ccacgttcta ccggcaggag ctgaacaaga caatctggga ggtgcccgag

361 cgttaccaga acctgtctcc agtgggctct ggcgcctatg gctctgtgtg tgctgctttt

421 gacacaaaaa cggggttacg tgtggcagtg aagaagctct ccagaccatt tcagtccatc

481 attcatgcga aaagaaccta cagagaactg cggttactta aacatatgaa acatgaaaat

541 gtgattggtc tgttggacgt ttttacacct gcaaggtctc tggaggaatt caatgatgtg

601 tatctggtga cccatctcat gggggcagat ctgaacaaca ttgtgaaatg tcagaagctt

661 acagatgacc atgttcagtt ccttatctac caaattctcc gaggtctaaa gtatatacat

721 tcagctgaca taattcacag ggacctaaaa cctagtaatc tagctgtgaa tgaagactgt

781 gagctgaaga ttctggattt tggactggct cggcacacag atgatgaaat gacaggctac

841 gtggccacta ggtggtacag ggctcctgag atcatgctga actggatgca ttacaaccag gθl acagttgata tttggtcagt gggatgcata atggccgagc tgttgactgg aagaacattg

961 tttcctggta cagaccatat tgatcagttg aagctcattt taagactcgt tggaacccca

1021 ggggctgagc ttttgaagaa aatctcctca gagtctgcaa gaaactatat tcagtctttg

1081 actcagatgc cgaagatgaa ctttgcgaat gtatttattg gtgccaatcc cctggctgtc

1141 gacttgctgg agaagatgct tgtattggac tcagataaga gaattacagc ggcccaagcc

1201 cttgcacatg cctactttgc tcagtaccac gatcctgatg atgaaccagt ggccgatcct

1261 tatgatcagt cctttgaaag cagggacctc cttatagatg agtggaaaag cctgacctat

1321 gatgaagtca tcagctttgt gccaccaccc cttgaccaag aagagatgga gtcctgagca

1381 cctggtttct gttctgttga tcccacttca ctgtgagggg aaggcctttt cacgggaact

1441 ctccaaatat tattcaagtg cctcttgttg cagagatttc ctccatggtg gaagggggtg

1501 tgcgtgcgtg tgcgtgcgtg ttagtgtgtg tgcatgtgt

(2) INFORMATION FOR SEQ ID NO:2679: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2679

1 tggttaacgc cagggttttc ccagtcacga acgttgtaaa acgacggcca gtgccaagct

61 aaaattaacc ttcactaaag ggaataagct tgcggccgct tcgggtttcc ggaggggccg

121 gagggcgggc gagggcgtca cgtgcgcgcc gcccgcgggc cggttggtcc ccgggcgggg

181 gaggggccgt gcgcagcctg ggtcggggtc gggccggggt cggcacctgg gacatccctg

241 agggaagggc cgggagcggg agcgccccag cggccggcgg gcgggcgggc gagcggacga

301 gcggcgcgga gccggcccga ggcgcgcgcc gagggagccc cgtccccggt cgtgggggca

361 ccgcccgcag gctctgcggg gtgggcagct cccgggcctg ccatgagctc tccgccgccc 421 gcccgcagtg gcttttaccg ccaggaggtg accaagacgg cctgggaggt gcgcgccgtg

481 taccgggacc tgcagcccgt gggctcgggc gcctacggcg cggtgtgctc ggccgtggac 541 ggccgcaccg gcgctaaggt ggccatcaag aagctgtatc ggcccttcca gtccgagctg 601 ttcgccaagc gcgcctaccg cgagctgcgc ctgctcaagc acatgcgcca cgagaacgtg 661 atcgggctgc tggacgtatt cactcctgat gagaccctgg atgacttcac ggacttttac 721 ctggtgatgc cgttcatggg caccgacctg ggcaagctca tgaaacatga gaagctaggc 781 gaggaccgga tccagttcct cgtgtaccag atgctgaagg ggctgaggta tatccacgct 841 gccggcatca tccacagaga cctgaagccc ggcaacctgg ctgtgaacga agactgtgag 901 ctgaagatcc tggacttcgg cctggccagg caggcagaca gtgagatgac tgggtacgtg 961 gtgacccggt ggtaccgggc tcccgaggtc atcttgaatt ggatgcgcta cacgcagacg

1021 gtggacatct ggtccgtggg ctgcatcatg gcggagatga tcacaggcaa gacgctgttc

1081 aagggcagcg accacctgga ccagctgaag gagatcatga aggtgacggg gacgcctccg

1141 gctgagtttg tgcagcggct gcagagcgat gaggccaaga acaacatgaa gggcctcccc

1201 gaattggaga agaaggattt tgcctctatc ctgaccaatg caagccctct ggctgtgaac

1261 ctcctggaga agatgctggt gctggacgcg gagcagcggg tgacggcagg cgaggcgctg

1321 gcccatccct acttcgagtc cctgcacgac acggaagatg agccccaggt ccagaagtat

1381 gatgactcct ttgacgacgt tgaccgcaca ctggatgaat ggaagcgtgt tacttacaaa

1441 gaggtgctca gcttcaagcc tccccggcag ctgggggcca gggtctccaa ggagacgcct

1501 ctgtgaagat ctctgggctc cggggtggca gtgaggacca ccttcacctt

(2) INFORMATION FOR SEQ ID NO:2680: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2680 EPI-109 889

1 ggaattccgg gcccggtctt tcctcccgcc gccgccggcc tggtcccggg gactggcctc

61 cacgtccgac tcgtccgagc tgaagcccag cagcactttg ctgccagccg cgggggcggc

121 ggaggcgccc ccgggccctc ccaggaggct ctctgggcca gaggccgaga ttcggcacag

181 gcccccagga gtccgtaagt aggagaggtc gcccgagacc ggccggaccc ccatccccgc

241 ggccgccgcc gccgctggtc ccgcggctgc gaccgtggcg gctgccgctg gaaaatgtct

301 caggagaggc ccacgttcta ccggcaggag ctgaacaaga caatctggga ggtgcccgag

361 cgttaccaga acctgtctcc agtgggctct ggcgcctatg gctctgtgtg tgctgctttt

421 gacacaaaaa cggggttacg tgtggcagtg aagaagctct ccagaccatt tcagtccatc

481 attcatgcga aaagaaccta cagagaactg cggttactta aacatatgaa acatgaaaat

541 gtgattggtc tgttggacgt ttttacacct gcaaggtctc tggaggaatt caatgatgtg

601 tatctggtga cccatctcat gggggcagat ctgaacaaca ttgtgaaatg tcagaagctt

661 acagatgacc atgttcagtt ccttatctac caaattctcc gaggtctaaa gtatatacat

721 tcagctgaca taattcacag ggacctaaaa cctagtaatc tagctgtgaa tgaagactgt

781 gagctgaaga ttctggattt tggactggct cggcacacag atgatgaaat gacaggctac

841 gtggccacta ggtggtacag ggctcctgag atcatgctga actggatgca ttacaaccag

901 acagttgata tttggtcagt gggatgcata atggccgagc tgttgactgg aagaacattg

961 tttcctggta cagaccatat tgatcagttg aagctcattt taagactcgt tggaacccca

1021 ggggctgagc ttttgaagaa aatctcctca gagtctgcaa gaaactatat tcagtctttg

1081 actcagatgc cgaagatgaa ctttgcgaat gtatttattg gtgccaatcc cctggctgtc

1141 gacttgctgg agaagatgct tgtattggac tcagataaga gaattacagc ggcccaagcc

1201 cttgcacatg cctactttgc tcagtaccac gatcctgatg atgaaccagt ggccgatcct

1261 tatgatcagt cctttgaaag cagggacctc cttatagatg agtggaaaag cctgacctat

1321 gatgaagtca tcagctttgt gccaccaccc cttgaccaag aagagatgga gtcctgagca

1381 cctggtttct gttctgttga tcccacttca ctgtgagggg aaggcctttt cacgggaact

1441 ctccaaatat tattcaagtg cctcttgttg cagagatttc ctccatggtg gaagggggtg

1501 tgcgtgcgtg tgcgtgcgtg ttagtgtgtg tgcatgtgt

1 tggttaacgc cagggttttc ccagtcacga acgttgtaaa acgacggcca gtgccaagct

61 aaaattaacc ttcactaaag ggaataagct tgcggccgct tcgggtttcc ggaggggccg

121 gagggcgggc gagggcgtca cgtgcgcgcc gcccgcgggc cggttggtcc ccgggcgggg

181 gaggggccgt gcgcagcctg ggtcggggtc gggccggggt cggcacctgg gacatccctg

241 agggaagggc cgggagcggg agcgccccag cggccggcgg gcgggcgggc gagcggacga

301 gcggcgcgga gccggcccga ggcgcgcgcc gagggagccc cgtccccggt cgtgggggca

361 ccgcccgcag gctctgcggg gtgggcagct cccgggcctg ccatgagctc tccgccgccc

421 gcccgcagtg gcttttaccg ccaggaggtg accaagacgg cctgggaggt gcgcgccgtg

481 taccgggacc tgcagcccgt gggctcgggc gcctacggcg cggtgtgctc ggccgtggac

541 ggccgcaccg gcgctaaggt ggccatcaag aagctgtatc ggcccttcca gtccgagctg

601 ttcgccaagc gcgcctaccg cgagctgcgc ctgctcaagc acatgcgcca cgagaacgtg

661 atcgggctgc tggacgtatt cactcctgat gagaccctgg atgacttcac ggacttttac

721 ctggtgatgc cgttcatggg caccgacctg ggcaagctca tgaaacatga gaagctaggc

781 gaggaccgga tccagttcct cgtgtaccag atgctgaagg ggctgaggta tatccacgct

841 gccggcatca tccacagaga cctgaagccc ggcaacctgg ctgtgaacga agactgtgag

901 ctgaagatcc tggacttcgg cctggccagg caggcagaca gtgagatgac tgggtacgtg

961 gtgacccggt ggtaccgggc tcccgaggtc atcttgaatt ggatgcgcta cacgcagacg

1021 gtggacatct ggtccgtggg ctgcatcatg gcggagatga tcacaggcaa gacgctgttc

1081 aagggcagcg accacctgga ccagctgaag gagatcatga aggtgacggg gacgcctccg

1141 gctgagtttg tgcagcggct gcagagcgat gaggccaaga acaacatgaa gggcctcccc

1201 gaattggaga agaaggattt tgcctctatc ctgaccaatg caagccctct ggctgtgaac

1261 ctcctggaga agatgctggt gctggacgcg gagcagcggg tgacggcagg cgaggcgctg

1321 gcccatccct acttcgagtc cctgcacgac acggaagatg agccccaggt ccagaagtat

1381 gatgactcct ttgacgacgt tgaccgcaca ctggatgaat ggaagcgtgt tacttacaaa

1441 gaggtgctca gcttcaagcc tccccggcag ctgggggcca gggtctccaa ggagacgcct

1501 ctgtgaagat ctctgggctc cggggtggca gtgaggacca ccttcacctt

(2) INFORMATION FOR SEQ ID NO: 2681: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2681

1 ctcgatcaaa cctttttttt atggtacaca atagtcacag tacttttcca tataaaacag

61 gtttagtggt cttaatttag tttggcacat ttaatacact cccatgacca gcatcccaaa

121 tgtacctatc cgttttattt tattgtctca gaattgtcag ttatttaata aattatgtaa

181 cttttttcct tatgctcaga tttgcacttc tttctaaaac tctgcccatc cttaaagtcc

241 cagattctcc ttgaactttt ttttttgact ttccaagtac atggaactct tcactctatc

301 ctgctatata aggtgacaga atttccacta tgggatagat ggagttcaat tcctttgagt

361 ttaaaataat ctaaatataa ttattcctta tgccctgttt ttccctcact tttgtatcca

421 aatctctttt cagacaacag aacaattaat gtctgataag gaagacaatg atgatgatca

481 cttcaaaatg aattcaggat tgtaatgtaa aattttagta ctctctcaca gtatggattc EPI-109 890

541 taacatggct tctaacccaa actaacatta gtagctctaa ctataaactt caaatttcag

601 tagatgcaac ctactccttt aaaatgaaac agaagattga aattattaaa ttatcaaaaa

661 gaaaatgatc cacgctctta gttgaaattt catgtaagat tccatgcaat aaataggagt

721 gccataaatg gaatgatgaa atatgactag aggaggagaa aggctcctag atgagatggg

781 attttaggca tccgtgtctc atgaggaatc agttgtgtca ctaggcaaaa cagtaaaaaa

841 aaaaacctcc aagtgagtct cttatttatt tttttcttat aagacttcta caaattgagg gθl tacctggtgt agttttattt caggttttat gctgtcattt tcctgtaatg ctaaggactt

961 aggacataac tgaattttct attttccact tcttttctgg tgtgtgtgta tatatatatg

1021 tatatataca cacacacata tacatatata tattttttag tatctcaccc tcacatgctc

1081 ctccctgagc actacccatg atagatgtta aacaaaagca aagatgaaat tccaactgtc

1141 aaaatccccc ctccatctaa ttaatccctc acccaactat gttccaaaac gagaatagaa

1201 aattagcccc aataagccca ggcaactgaa aagtaaatgc tatgttgtac tttgatccat

1261 ggtcacaact cataatcttg gaaaagtgga cagaaaagac aaaagagtga actttaaaac

1321 tcgaatttat tttaccagta tctcctatga agggctagta accaaaataa tccacgcatc

1381 agggagagaa atgccttaag gcatacgttt tggacattta gcgtccctgc aaattctggc

1441 catcgccgct tcctttgtcc atcagaaggc aggaaacttt atattggtga cccgtggagc

1501 tcacattaac tatttacagg gtaactgctt aggaccagta ttatgaggag aatttacctt

1561 tcccgcctct ctttccaaga aacaaggagg gggtgaaggt acggagaaca gtatttcttc

1621 tgttgaaagc aacttagcta caaagataaa ttacagctat gtacactgaa ggtagctatt

1681 tcattccaca aaataagagt tttttaaaaa gctatgtatg tatgtgctgc atatagagca

1741 gatatacagc ctattaagcg tcgtcactaa aacataaaac atgtcagcct ttcttaacct

1801 tactcgcccc agtctgtccc gacgtgactt cctcgaccct ctaaagacgt acagaccaga

1861 cacggcggcg gcggcgggag aggggattcc ctgcggcccc ggacctcagg gccgctcaga

1921 ttcctggaga ggaagccaag tgtccttctg ccctcccccg gtatcccatc caaggcgatc

1981 agtccacaac tggctctcgg aagcactcgg gcaaagactg cgaagaagaa aagacatctg

2041 gcggaaacct gtgcgcctgg ggcggtggaa ctcggggagg agagggaggg atcagacagg

2101 agagtgggga ctaccccctc tgctcccaaa ttggggcagc ttcctgggtt tccgattttc

2161 tcatttccgt gggtaaaaaa ccctgccccc accggcttac gcaatttttt taaggggaga

2221 ggagggaaaa atttgtgggg ggtacgaaaa ggcggaaaga aacagtcatt tcgtcacatg

2281 ggcttggttt tcagtcttat aaaaaggaag gttctctcgg ttagcgacca attgtcatac

2341 gacttgcagt gagcgtcagg agcacgtcca ggaactcctc agcagcgcct ccttcagctc

(2) INFORMATION FOR SEQ ID NO: 2682: (i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2682

1 gtccaggaac tcctcagcag cgcctccttc agctccacag ccagacgccc tcagacagca

61 aagcctaccc ccgcgccgcg ccctgcccgc cgctgcgatg ctcgcccgcg ccctgctgct

121 gtgcgcggtc ctggcgctca gccatacagc aaatccttgc tgttcccacc catgtcaaaa

181 ccgaggtgta tgtatgagtg tgggatttga ccagtataag tgcgattgta cccggacagg

241 attctatgga gaaaactgct caacaccgga atttttgaca agaataaaat tatttctgaa

301 acccactcca aacacagtgc actacatact tacccacttc aagggatttt ggaacgttgt

361 gaataacatt cccttccttc gaaatgcaat tatgagttat gtgttgacat ccagatcaca

421 tttgattgac agtccaccaa cttacaatgc tgactatggc tacaaaagct gggaagcctt

481 ctctaacctc tcctattata ctagagccct tcctcctgtg cctgatgatt gcccgactcc

541 cttgggtgtc aaaggtaaaa agcagcttcc tgattcaaat gagattgtgg gaaaattgct

601 tctaagaaga aagttcatcc ctgatcccca gggctcaaac atgatgtttg cattctttgc

661 ccagcacttc acgcatcagt ttttcaagac agatcataag cgagggccag ctttcaccaa

721 cgggctgggc catggggtgg acttaaatca tatttacggt gaaactctgg ctagacagcg

781 taaactgcgc cttttcaagg atggaaaaat gaaatatcag ataattgatg gagagatgta

841 tcctcccaca gtcaaagata ctcaggcaga gatgatctac cctcctcaag tccctgagca

901 tctacggttt gctgtggggc aggaggtctt tggtctggtg cctggtctga tgatgtatgc

961 cacaatctgg ctgagggaac acaacagagt atgcgatgtg cttaaacagg agcatcctga

1021 atggggtgat gagcagttgt tccagacaag caggctaata ctgataggag agactattaa

1081 gattgtgatt gaagattatg tgcaacactt gagtggctat cacttcaaac tgaaatttga

1141 cccagaacta cttttcaaca aacaattcca gtaccaaaat cgtattgctg ctgaatttaa

1201 caccctctat cactggcatc cccttctgcc tgacaccttt caaattcatg accagaaata

1261 caactatcaa cagtttatct acaacaactc tatattgctg gaacatggaa ttacccagtt

1321 tgttgaatca ttcaccaggc aaattgctgg cagggttgct ggtggtagga atgttccacc

1381 cgcagtacag aaagtatcac aggcttccat tgaccagagc aggcagatga aataccagtc

1441 ttttaatgag taccgcaaac gctttatgct gaagccctat gaatcatttg aagaacttac

1501 aggagaaaag gaaatgtctg cagagttgga agcactctat ggtgacatcg atgctgtgga

1561 gctgtatcct gcccttctgg tagaaaagcc tcggccagat gccatctttg gtgaaaccat

1621 ggtagaagtt ggagcaccat tctccttgaa aggacttatg ggtaatgtta tatgttctcc

1681 tgcctactgg aagccaagca cttttggtgg agaagtgggt tttcaaatca tcaacactgc

1741 ctcaattcag tctctcatct gcaataacgt gaagggctgt ccctttactt cattcagtgt EPI-109 891

1801 tccagatcca gagctcatta aaacagtcac catcaatgca agttcttccc gctccggact

1861 agatgatatc aatcccacag tactactaaa agaacgttcg actgaactgt agaagtctaa

1921 tgatcatatt tatttattta tatgaaccat gtctattaat ttaattattt aataatattt

1981 atattaaact ccttatgtta cttaacatct tctgtaacag aagtcagtac tcctgttgcg

2041 gagaaaggag tcatacttgt gaagactttt atgtcactac tctaaagatt ttgctgttgc

2101 tgttaagttt ggaaaacagt ttttattctg ttttataaac cagagagaaa tgagttttga

2161 cgtcttttta cttgaatttc aacttatatt ataaggacga aagtaaagat gtttgaatac

2221 ttaaacacta tcacaagatg ccaaaatgct gaaagttttt acactgtcga tgtttccaat

2281 gcatcttcca tgatgcatta gaagtaacta atgtttgaaa ttttaaagta cttttgggta

2341 tttttctgtc atcaaacaaa acaggtatca gtgcattatt aaatgaatat ttaaattaga

2401 cattaccagt aatttcatgt ctacttttta aaatcagcaa tgaaacaata atttgaaatt

2461 tctaaattca tagggtagaa tcacctgtaa aagcttgttt gatttcttaa agttattaaa

2521 cttgtacata taccaaaaag aagctgtctt ggatttaaat ctgtaaaatc agatgaaatt

2581 ttactacaat tgcttgttaa aatattttat aagtgatgtt cctttttcac caagagtata

2641 aaccttttta gtgtgactgt taaaacttcc ttttaaatca aaatgccaaa tttattaagg

2701 tggtggagcc actgcagtgt tatctcaaaa taagaatatc ctgttgagat attccagaat

2761 ctgtttatat ggctggtaac atgtaaaaac cccataaccc cgccaaaagg ggtcctaccc

2821 ttgaacataa agcaataacc aaaggagaaa agcccaaatt attggttcca aatttagggt

2881 ttaaactttt tgaagcaaac ttttttttag ccttgtgcac tgcagacctg gtactcagat

2941 tttgctatga ggttaatgaa gtaccaagct gtgcttgaat aacgatatgt tttctcagat

3001 tttctgttgt acagtttaat ttagcagtcc atatcacatt gcaaaagtag caatgacctc

3061 ataaaatacc tcttcaaaat gcttaaattc atttcacaca ttaattttat ctcagtcttg

3121 aagccaattc agtaggtgca ttggaatcaa gcctggctac ctgcatgctg ttccttttct

3181 tttcttcttt tagccatttt gctaagagac acagtcttct caaacacttc gtttctccta

3241 ttttgtttta ctagttttaa gatcagagtt cactttcttt ggactctgcc tatattttct

3301 tacctgaact tttgcaagtt ttcaggtaaa cctcagctca ggactgctat ttagctcctc

3361 ttaagaagat taaaaaaaaa aaaaaag

(2) INFORMATION FOR SEQ ID NO: 2683: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2683

1 gagctcacat taactattta cagggtaact gcttaggacc agtattatga ggagaattta

61 cctttcccgc ctctctttcc aagaaacaag gagggggtga aggtacggag aacagtattt

121 cttctgttga aagcaactta gctacaaaga taaattacag ctatgtacac tgaaggtagc

181 tatttcattc cacaaaataa gagtttttta aaaagctatg tatgtatgtg ctgcatatag

241 agcagatata cagcctatta agcgtcgtca ctaaaacata aaacatgtca gcctttctta

301 accttactcg ccccagtctg tcccgacgtg acttcctcga ccctctaaag acgtacagac

361 cagacacggc ggcggcggcg ggagagggga ttccctgcgc ccccggacct cagggccgct

421 cagattcctg gagaggaagc caagtgtcct tctgccctcc cccggtatcc catccaaggc

481 gatcagtcca gaactggctc tcggaagcgc tcgggcaaag actgcgaaga agaaaagaca

541 tctggcggaa acctgtgcgc ctggggcggt ggaactcggg gaggagaggg agggatcaga

601 caggagagtg gggactacc.c cctctgctcc caaattgggg cagcttcctg ggtttccgat

661 tttctcattt ccgtgggtaa aaaaccctgc ccccaccggg cttacgcaat ttttttaagg

721 ggagaggagg gaaaaaattt gtgggggggt acgaaaaggc ggaaagaaac agtcattcac

781 atgggcttgg ttttcagtct tataaaaagg aaggttctct cggttagcga ccaattgtca

841 tacgacttgc agtgagcgtc aggagcacgt ccaggaactc ctcagcagcg cctccttcag

901 ctccacagcc agacgccctc agacagcaaa gcctaccccc gcgccgcgcc ctgcccgccg

961 ctcggatgct cgcccgcgcc ctgctgctgt gcgcggtcct ggcgctcagc catacaggtg

1021 agtacctggc gccgcgcacc ggggactccg gttccacgca cccgggcaga gtttccgctc

1081 tgacctcctg ggtctatccc agtactccga cttctctccg aatagagaag ctacgtgact

1141 tgggaaagag cttggaccgc tagagtccga aagaactccg tggatattcc agctttccca

1201 caagcactga tcattatgag ccagttactt aaccgatctg agacactctc acctcctaaa

1261 tagggataga tgatactaat ttgcaggttg tcattatgat aagacaggat ctgatcaata

1321 tatgtgaatt gtttatattt ggaacctttt tattgagtgg aagaagttgt tttaaatatt

1381 ctagtcagtt ctttcctgct cccaggaaag cccggattat gttttaagat aagcaaaatg

1441 tcttaaaagt aagctgtttt actttgaatt tttccctaaa tgttgattag tgtactagat

1501 ccattttaat ttggaaagtg aagtgctact tatttgaact tcttaaaaat gctaatttta

1561 acatctaaag agttaactaa gaaaagctta gtaacatgat gtaccaagtt gaatatgctg

1621 ttatccttat ttagaataga aaattggtat ttctacgttt tatccattct aaggcaggtt

1681 aaaaaattgt atttccatga ctacctatat atttcttgaa tttattattg taaagttgat

1741 tcatagtcaa acaattaaat gtttaaatta agattaagac actagagaat gatttatttg

1801 ctgtccttta attgcagcaa atccttgctg ttcccaccca tgtcaaaacc gaggtgtatg

1861 tatgagtgtg ggatttgacc agtataagtg cgattgtacc cggacaggat tctatggaga

1921 aaactgctca acacgtaagt ttgtcctttg gttgcctcat taggagtggg gctggataca

1981 gttatcattg tatagatttg tgtcttataa tgagtcccat taatttctcc ctccctttct EPI-109 892

2041 tcgtcttctt gcagcggaat ttttgacaag aataaaatta tttctgaaac ccactccaaa 2101 cacagtgcac tacatactta cccacttcaa gggattttgg aacgttgtga ataacattcc 2161 cttccttcga aatgcaatta tgagttatgt cttgacatgt aagtacaagt gtctttctaa 2221 ggtttttagc cttctcaaag aaaaatatgc tttataatac tgtaagccta atctaaaaac 2281 atatttccaa gcttatcaaa aagactttaa gatagctttt aagtttgcct tccatcttaa 2341 tcgccaaaaa tattgacatt tagtcccatc cagtttatac agtctgctca caactctgta 2401 tacctcttct aacctttact gtttggtcag tttgtggagg tagcatggtc cagctgttta 2461 ttgaatgccc atgggccaca gaattgttct gaacatgtag cacccattaa aataaatttg 2521 gatttggatc agcaagaaaa taactttcca tgattctaaa gtgggtgcca tactcagcca 2581 ttcctttcat aggcctcttg gatagtgagc agatggctac ctgaaaaatc aatattgcca 2641 gattataatg tgcagagtat atgtatttta ttaaagatgt atttcaagtg gccattagac 2701 tataaagtgt agttgtttaa aaatagattt tttttatttt ggagttacat tcaacctcag 2761 gtgccacttt ccacatttta caataaaaat aatggttgat ttacttaaca aatgagaata 2821 aataaaacat ttttttcttt gaaaatttca gccagatcac atttgattga cagtccacca 2881 acttacaatg ctgactatgg ctacaaaagc tgggaagcct tctctaacct ctcctattat 2941 actagagccc ttcctcctgt gcctgatgat tgcccgactc ccttgggtgt caaaggtgag 3001 taagaagaat ccattagaga tgtattaact ataagacggg ctgcattgct gccaaaaaaa 3061 aaaattgacc ttagactacc atttatttat taacaaaagc agtttttact tttagcatgg 3121 ttatctatgg gtatttttta aagtatgagt ctatataaac tattatgtaa aagcaaatga 3181 gcgtcttggt ataatgtctt aatattttca aattatttct ttagaaatga aataattcta 3241 attaaaatag ataaaatcat tcagtaagaa gttgttccac catatcttag aactgttgtt 3301 tatattatga tcctattcac aattgtaatt ctcatataaa tgaagaattc ttggtagatt 3361 gacagtcacc atctcctttc ttgaatacat agatggattc ttaccttagc tttctcattt 3421 ttcaggtaaa aagcagcttc ctgattcaaa tgagattgtg gaaaaattgc ttctaagaag 3481 aaagttcatc cctgatcccc agggctcaaa catgatgttt gcattctttg cccagcactt 3541 cacgcatcag tttttcaaga cagatcataa gcgagggcca gctttcacca acgggctggg 3601 ccatggggta agatagagtt aatatcttag agttagtaaa attataccaa atcatagtca 3661 agggctaaca ttaaaggaga tatacagata gatagatcca aataacttat ccactttttt 3721 taaaaagaag tcttatctat aaaaacctta aaggaatttt ccatttactt cactggtcta 3781 gtaaaattat acacacacac agacatgcac acacatatat aaacattcac acacatacat 3841 atgtacaggt attgttattt gtaatttgac ccttgtattt tttagtttaa aatgttagta 3901 ctgcaaaatg ttatgtcctc aaaaacacat tgtaccatga ttatgccgct ttcaatattg 3961 taaagtgagg tttttgccgc attattattt tttggatttc aatagcatag cttcaagtta 4021 ttcgtaagaa ttttttataa ataatacatt tttatacttt tttataatta ccatatcatc 4081 atagtgaagt atataatata tatgatataa gctcaatata gtatattaat tccgttaaac 4141 acaaagacat atcagtttgt agctttggtg gataaacaaa ttaatttagc aattcatggc 4201 tatgaaaaat gtatatttta tttaaaaatt ttaaagaaag ctaaatgatc aaattattta 4261 atgatgaatt atatgataga cactttatat aagaaaaact tcaacagcaa caaattaaaa 4321 ttttttcatc attttctagg tggacttaaa tcatatttac ggtgaaactc tggctagaca 4381 gcgtaaactg cgccttttca aggatggaaa aatgaaatat caggtatgct tcctttgact 4441 attaagactt agttattacc gcttataccc atattttaaa atccctaaaa atgtgttcct 4501 taacttttta actgatgttt atttatttat ttattttttt agataattga tggagagatg 4561 tatcctccca cagtcaaaga tactcaggca gagatgatct accctcctca agtccctgag 4621 catctacggt ttgctgtggg gcaggaggtc tttggtctgg tgcctggtct gatgatgtat 4681 gccacaatct ggctgcggga acacaacaga gtatgcgatg tgcttaaaca ggagcatcct 4741 gaatggggtg atgagcagtt gttccagaca agcaggctaa tactgatagg taaacaagaa 4801 aatgatttat ataaaaccct cttccccagg gaaaattagt gtgctatctt tgttatgttt 4861 tgagtaaatg acaagatgtg gtaaatgaaa actcacacat tctatataca ttaaatatgt 4921 aagcatgact gataaaatag ctatcttttg atactgacaa ggaagaaaac agaaatgaag 4981 gaatagcaaa ttttaaaaat tgcattccag ttgcttgaaa gcttgtgatc agatgcaata 5041 aatgttttta ttatttattt tgtgcaaata ggagagacta ttaagattgt gattgaagat 5101 tatgtgcaac acttgagtgg ctatcacttc aaactgaaat ttgacccaga actacttttc 5161 aacaaacaat tccagtacca aaatcgtatt gctgctgaat ttaacaccct ctatcactgg 5221 catccccttc tgcctgacac ctttcaaatt catgaccaga aatacaacta tcaacagttt 5281 atctacaaca actctatatt gctggaacat ggaattaccc agtttgttga atcattcacc 5341 aggcaaattg ctggcagggt aagcattatt attgaaaacc aaaacaaaag actagtcagt 5401 aactttagaa tttctgccac ggaaattatt tttcttaaac ttactaaaag agtagttagt 5461 tatattgcta gtaaaattat tttattgata taagaagcct aactttgttt gaaaagtcta 5521 aacttttagt ctagtctaca gttgtcagac aaatagcaaa ttgtacccct accttaaaaa 5581 tattttcaaa aagtatctat aatcttatag gaataaatat tttaggcttg aatactagtg 5641 ttatttttga aatgtaaaaa ggcaaattag ttctaggctg gtgtcccatt gaattttaag 5701 cagagctcct gttgaaatgt aggtaagcat ctttccagca aataaaaatt gtctccgctg 5761 ggagtttcag ttttacctga tttgtaccta aggcaagctg aatacaaaca gtaaatatgc 5821 ctaaaattct tgttttacaa ctaattttac tttccacagg ttgctggtgg taggaatgtt 5881 ccacccgcag tacagaaagt atcacaggct tccattgacc agagcaggca gatgaaatac 5941 cagtctttta atgagtaccg caaacgcttt atgctgaagc cctatgaatc atttgaagaa 6001 cttacaggta agaaacagtt tctaaacttc ttcgtttttt gtttgtttgt ttgtttttgt 6061 tgtttttggt tttcttttcg agatggagcc gccctctgtc acccaggctg gagtgcagtg EPI-109 893

6121 gcgccatctc ggctcactgc aacctccgcc tcctgggttc aagcaattct cctgcctcaa

6181 cttcctgagt agctgggact acaggctcac gtcgcacgca tggataattt tttgtatttt

6241 cagtatagac ggggtttcac cgtgttagcc aggctggtct caaactcctg acctagtgat

6301 ccgccggctt cggcctcccg aagtgctggg attacaggcg tgagccaccg cgcctggccc

6361 ctaaacttct taaaagaatc aggggtcaaa tggaaacaga gaagttggca gcaaattgag

6421 caaaagaatc aaactgtttt ttattttgtg aagtttgaca ttggttgtat ctctgtcttc

6481 atcgccttca caggagaaaa ggaaatgtct gcagagttgg aagcactcta tggtgacatc

6541 gatgctgtgg agctgtatcc tgcccttctg gtagaaaagc ctcggccaga tgccatcttt

6601 ggtgaaacca tggtagaagt tggagcacca ttctccttga aaggacttat gggtaatgtt

6661 atatgttctc ctgcctactg gaagccaagc acttttggtg gagaagtggg ttttcaaatc

6721 atcaacactg cctcaattca gtctctcatc tgcaataacg tgaagggctg tccctttact

6781 tcattcagtg ttccagatcc agagctcatt aaaacagtca ccatcaatgc aagttcttcc

6841 cgctccggac tagatgatat caatcccaca gtactactaa aagaacgttc gactgaactg

6901 tagaagtcta atgatcatat ttatttattt atatgaacca tgtctattaa tttaattatt

6961 taataatatt tatattaaac tccttatgtt acttaacatc ttctgtaaca gaagtcagta

7021 ctcctgttgc ggagaaagga gtcatacttg tgaagacttt tatgtcacta ctctaaagat

7081 tttgctgttg ctgttaagtt tggaaaacag tttttattct gttttataaa ccagagagaa

7141 atgagttttg acgtcttttt acttgaattt caacttatat tataagaacg aaagtaaaga

7201 tgtttgaata cttaaacact atcacaagat ggcaaaatgc tgaaagtttt tacactgtcg

7261 atgtttccaa tgcatcttcc atgatgcatt agaagtaact aatgtttgaa attttaaagt

7321 acttttggtt atttttctgt catcaaacaa aaacaggtat cagtgcatta ttaaatgaat

7381 atttaaatta gacattacca gtaatttcat gtctactttt taaaatcagc aatgaaacaa

7441 taatttgaaa tttctaaatt catagggtag aatcacctgt aaaagcttgt ttgatttctt

7501 aaagttatta aacttgtaca tataccaaaa agaagctgtc ttggatttaa atctgtaaaa

7561 tcagatgaaa ttttactaca attgcttgtt aaaatatttt ataagtgatg ttcctttttc

7621 accaagagta taaacctttt tagtgtgact gttaaaactt ccttttaaat caaaatgcca

7681 aatttattaa ggtggtggag ccactgcagt gttatctcaa aataagaata ttttgttgag

7741 atattccaga atttgtttat atggctggta acatgtaaaa tctatatcag caaaagggtc

7801 tacctttaaa ataagcaata acaaagaaga aaaccaaatt attgttcaaa tttaggttta

7861 aacttttgaa gcaaactttt ttttatcctt gtgcactgca ggcctggtac tcagattttg

7921 ctatgaggtt aatgaagtac caagctgtgc ttgaataacg atatgttttc tcagattttc

7981 tgttgtacag tttaatttag cagtccatat cacattgcaa aagtagcaat gacctcataa

8041 aatacctctt caaaatgctt aaattcattt cacacattaa ttttatctca gtcttgaagc

8101 caattcagta ggtgcattgg aatcaagcct ggctacctgc atgctgttcc ttttcttttc

8161 ttcttttagc cattttgcta agagacacag tcttctcatc acttcgtttc tcctattttg

8221 ttttactagt tttaagatca gagttcactt tctttggact ctgcctatat tttcttacct

8281 gaacttttgc aagttttcag gtaaacctca gctcaggact gctatttagc tcctcttaag

8341 aagattaaaa gagaaaaaaa aaggcccttt taaaaatagt atacacttat tttaagtgaa

8401 aagcagagaa ttttatttat agctaatttt agctatctgt aaccaagatg gatgcaaaga

8461 ggctagtgcc tcagagagaa ctgtacgggg tttgtgactg gaaaaagtta cgttcccatt

8521 ctaattaatg ccctttctta tttaaaaaca aaaccaaatg atatctaagt agttctcagc

8581 aataataata atgacgataa tacttctttt ccacatctca ttgtcactga catttaatgg

8641 tactgtatat tacttaattt attgaagatt attatttatg tcttattagg acactatggt

8701 tataaactgt gtttaagcct acaatcattg attttttttt gttatgtcac aatcagtata

8761 ttttctttgg ggttacctct ctgaatatta tgtaaacaat ccaaagaaat gattgtatta

8821 agatttgtga ataaattttt agaaatctga ttggcatatt gagatattta aggttgaatg

8881 tttgtcctta ggataggcct atgtgctagc ccacaaagaa tattgtctca ttagcctgaa

8941 tgtgccataa gactgacctt ttaaaatgtt ttgagggatc tgtggatgct tcgttaattt

9001 gttcagccac aatttattga gaaaatattc tgtgtcaagc actgtgggtt ttaatatttt

9061 taaatcaaac gctgattaca gataatagta tttatataaa taattgaaaa aaattttctt

9121 ttgggaagag ggagaaaatg aaataaatat cattaaagat aactcaggag aatcttcttt

9181 acaattttac gtttagaatg tttaaggtta agaaagaaat agtcaatatg cttgtataaa

9241 acactgttca ctgttttttt taaaaaaaaa acttgatttg ttattaacat tgatctgctg

9301 acaaaacctg ggaatttggg ttgtgtatgc gaatgtttca gtgcctcaga caaatgtgta

9361 tttaacttat gtaaaagata agtctggaaa taaatgtctg tttatttttg tactatttaa

9421 aaaaaaaaaa aaaaatcgat gtcgactcga gtc

(2) INFORMATION FOR SEQ ID NO: 2684: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2684

1 ctcgatcaaa cctttttttt atggtacaca atagtcacag tacttttcca tataaaacag

61 gtttagtggt cttaatttag tttggcacat ttaatacact cccatgacca gcatcccaaa

121 tgtacctatc cgttttattt tattgtctca gaattgtcag ttatttaata aattatgtaa

181 cttttttcct tatgctcaga tttgcacttc tttctaaaac tctgcccatc cttaaagtcc

241 cagattctcc ttgaactttt ttttttgact ttccaagtac atggaactct tcactctatc EPI-109 894

301 ctgctatata aggtgacaga atttccacta tgggatagat ggagttcaat tcctttgagt

361 ttaaaataat ctaaatataa ttattcctta tgccctgttt ttccctcact tttgtatcca

421 aatctctttt cagacaacag aacaattaat gtctgataag gaagacaatg atgatgatca

481 cttcaaaatg aattcaggat tgtaatgtaa aattttagta ctctctcaca gtatggattc

541 taacatggct tctaacccaa actaacatta gtagctctaa ctataaactt caaatttcag

601 tagatgcaac ctactccttt aaaatgaaac agaagattga aattattaaa ttatcaaaaa

661 gaaaatgatc cacgctctta gttgaaattt catgtaagat tccatgcaat aaataggagt

721 gccataaatg gaatgatgaa atatgactag aggaggagaa aggctcctag atgagatggg

781 attttaggca tccgtgtctc atgaggaatc agttgtgtca ctaggcaaaa cagtaaaaaa

841 aaaaacctcc aagtgagtct cttatttatt tttttcttat aagacttcta caaattgagg

901 tacctggtgt agttttattt caggttttat gctgtcattt tcctgtaatg ctaaggactt

961 aggacataac tgaattttct attttccact tcttttctgg tgtgtgtgta tatatatatg

1021 tatatataca cacacacata tacatatata tattttttag tatctcaccc tcacatgctc

1081 ctccctgagc actacccatg atagatgtta aacaaaagca aagatgaaat tccaactgtc

1141 aaaatccccc ctccatctaa ttaatccctc acccaactat gttccaaaac gagaatagaa

1201 aattagcccc aataagccca ggcaactgaa aagtaaatgc tatgttgtac tttgatccat

1261 ggtcacaact cataatcttg gaaaagtgga cagaaaagac aaaagagtga actttaaaac

1321 tcgaatttat tttaccagta tctcctatga agggctagta accaaaataa tccacgcatc

1381 agggagagaa atgccttaag gcatacgttt tggacattta gcgtccctgc aaattctggc

1441 catcgccgct tcctttgtcc atcagaaggc aggaaacttt atattggtga cccgtggagc

1501 tcacattaac tatttacagg gtaactgctt aggaccagta ttatgaggag aatttacctt

1561 tcccgcctct ctttccaaga aacaaggagg gggtgaaggt acggagaaca gtatttcttc

1621 tgttgaaagc aacttagcta caaagataaa ttacagctat gtacactgaa ggtagctatt

1681 tcattccaca aaataagagt tttttaaaaa gctatgtatg tatgtgctgc atatagagca

1741 gatatacagc ctattaagcg tcgtcactaa aacataaaac atgtcagcct ttcttaacct

1801 tactcgcccc agtctgtccc gacgtgactt cctcgaccct ctaaagacgt acagaccaga

1861 cacggcggcg gcggcgggag aggggattcc ctgcggcccc ggacctcagg gccgctcaga

1921 ttcctggaga ggaagccaag tgtccttctg ccctcccccg gtatcccatc caaggcgatc

1981 agtccacaac tggctctcgg aagcactcgg gcaaagactg cgaagaagaa aagacatctg

2041 gcggaaacct gtgcgcctgg ggcggtggaa ctcggggagg agagggaggg atcagacagg

2101 agagtgggga ctaccccctc tgctcccaaa ttggggcagc ttcctgggtt tccgattttc

2161 tcatttccgt gggtaaaaaa ccctgccccc accggcttac gcaatttttt taaggggaga

2221 ggagggaaaa atttgtgggg ggtacgaaaa ggcggaaaga aacagtcatt tcgtcacatg

2281 ggcttggttt tcagtcttat aaaaaggaag gttctctcgg ttagcgacca attgtcatac

2341 gacttgcagt gagcgtcagg agcacgtcca ggaactcctc agcagcgcct ccttcagctc

1 gtccaggaac tcctcagcag cgcctccttc agctccacag ccagacgccc tcagacagca

61 aagcctaccc ccgcgccgcg ccctgcccgc cgctgcgatg ctcgcccgcg ccctgctgct

121 gtgcgcggtc ctggcgctca gccatacagc aaatccttgc tgttcccacc catgtcaaaa

181 ccgaggtgta tgtatgagtg tgggatttga ccagtataag tgcgattgta cccggacagg

241 attctatgga gaaaactgct caacaccgga atttttgaca agaataaaat tatttctgaa

301 acccactcca aacacagtgc actacatact tacccacttc aagggatttt ggaacgttgt

361 gaataacatt cccttccttc gaaatgcaat tatgagttat gtgttgacat ccagatcaca

421 tttgattgac agtccaccaa cttacaatgc tgactatggc tacaaaagct gggaagcctt

481 ctctaacctc tcctattata ctagagccct tcctcctgtg cctgatgatt gcccgactcc

541 cttgggtgtc aaaggtaaaa agcagcttcc tgattcaaat gagattgtgg gaaaattgct

601 tctaagaaga aagttcatcc ctgatcccca gggctcaaac atgatgtttg cattctttgc

661 ccagcacttc acgcatcagt ttttcaagac agatcataag cgagggccag ctttcaccaa

721 cgggctgggc catggggtgg acttaaatca tatttacggt gaaactctgg ctagacagcg

781 taaactgcgc cttttcaagg atggaaaaat gaaatatcag ataattgatg gagagatgta

841 tcctcccaca gtcaaagata ctcaggcaga gatgatctac cctcctcaag tccctgagca

901 tctacggttt gctgtggggc aggaggtctt tggtctggtg cctggtctga tgatgtatgc

961 cacaatctgg ctgagggaac acaacagagt atgcgatgtg cttaaacagg agcatcctga

1021 atggggtgat gagcagttgt tccagacaag caggctaata ctgataggag agactattaa

1081 gattgtgatt gaagattatg tgcaacactt gagtggctat cacttcaaac tgaaatttga

1141 cccagaacta cttttcaaca aacaattcca gtaccaaaat cgtattgctg ctgaatttaa

1201 caccctctat cactggcatc cccttctgcc tgacaccttt caaattcatg accagaaata

1261 caactatcaa cagtttatct acaacaactc tatattgctg gaacatggaa ttacccagtt

1321 tgttgaatca ttcaccaggc aaattgctgg cagggttgct ggtggtagga atgttccacc

1381 cgcagtacag aaagtatcac aggcttccat tgaccagagc aggcagatga aataccagtc

1441 ttttaatgag taccgcaaac gctttatgct gaagccctat gaatcatttg aagaacttac

1501 aggagaaaag gaaatgtctg cagagttgga agcactctat ggtgacatcg atgctgtgga

1561 gctgtatcct gcccttctgg tagaaaagcc tcggccagat gccatctttg gtgaaaccat

1621 ggtagaagtt ggagcaccat tctccttgaa aggacttatg ggtaatgtta tatgttctcc

1681 tgcctactgg aagccaagca cttttggtgg agaagtgggt tttcaaatca tcaacactgc

1741 ctcaattcag tctctcatct gcaataacgt gaagggctgt ccctttactt cattcagtgt

1801 tccagatcca gagctcatta aaacagtcac catcaatgca agttcttccc gctccggact

1861 agatgatatc aatcccacag tactactaaa agaacgttcg actgaactgt agaagtctaa

1921 tgatcatatt tatttattta tatgaaccat gtctattaat ttaattattt aataatattt EPI-109 895

1981 atattaaact ccttatgtta cttaacatct tctgtaacag aagtcagtac tcctgttgcg 2041 gagaaaggag tcatacttgt gaagactttt atgtcactac tctaaagatt ttgctgttgc 2101 tgttaagttt ggaaaacagt ttttattctg ttttataaac cagagagaaa tgagttttga 2161 cgtcttttta cttgaatttc aacttatatt ataaggacga aagtaaagat gtttgaatac 2221 ttaaacacta tcacaagatg ccaaaatgct gaaagttttt acactgtcga tgtttccaat 2281 gcatcttcca tgatgcatta gaagtaacta atgtttgaaa ttttaaagta cttttgggta 2341 tttttctgtc atcaaacaaa acaggtatca gtgcattatt aaatgaatat ttaaattaga 2401 cattaccagt aatttcatgt ctacttttta aaatcagcaa tgaaacaata atttgaaatt 2461 tctaaattca tagggtagaa tcacctgtaa aagcttgttt gatttcttaa agttattaaa 2521 cttgtacata taccaaaaag aagctgtctt ggatttaaat ctgtaaaatc agatgaaatt 2581 ttactacaat tgcttgttaa aatattttat aagtgatgtt cctttttcac caagagtata 2641 aaccttttta gtgtgactgt taaaacttcc ttttaaatca aaatgccaaa tttattaagg 2701 tggtggagcc actgcagtgt tatctcaaaa taagaatatc ctgttgagat attccagaat 2761 ctgtttatat ggctggtaac atgtaaaaac cccataaccc cgccaaaagg ggtcctaccc 2821 ttgaacataa agcaataacc aaaggagaaa agcccaaatt attggttcca aatttagggt 2881 ttaaactttt tgaagcaaac ttttttttag ccttgtgcac tgcagacctg gtactcagat 2941 tttgctatga ggttaatgaa gtaccaagct gtgcttgaat aacgatatgt tttctcagat 3001 tttctgttgt acagtttaat ttagcagtcc atatcacatt gcaaaagtag caatgacctc 3061 ataaaatacc tcttcaaaat gcttaaattc atttcacaca ttaattttat ctcagtcttg 3121 aagccaattc agtaggtgca ttggaatcaa gcctggctac ctgcatgctg ttccttttct 3181 tttcttcttt tagccatttt gctaagagac acagtcttct caaacacttc gtttctccta 3241 ttttgtttta ctagttttaa gatcagagtt cactttcttt ggactctgcc tatattttct 3301 tacctgaact tttgcaagtt ttcaggtaaa cctcagctca ggactgctat ttagctcctc 3361 ttaagaagat taaaaaaaaa aaaaaag

1 gagctcacat taactat^'tta cagggtaact gcttaggacc agtattatga ggagaattta

61 cctttcccgc ctctctttcc aagaaacaag gagggggtga aggtacggag aacagtattt

121 cttctgttga aagcaactta gctacaaaga taaattacag ctatgtacac tgaaggtagc

181 tatttcattc cacaaaataa gagtttttta aaaagctatg tatgtatgtg ctgcatatag

241 agcagatata cagcctatta agcgtcgtca ctaaaacata aaacatgtca gcctttctta

301 accttactcg ccccagtctg tcccgacgtg acttcctcga ccctctaaag acgtacagac

361 cagacacggc ggcggcggcg ggagagggga ttccctgcgc ccccggacct cagggccgct

421 cagattcctg gagaggaagc caagtgtcct tctgccctcc cccggtatcc catccaaggc

481 gatcagtcca gaactggctc tcggaagcgc tcgggcaaag actgcgaaga agaaaagaca

541 tctggcggaa acctgtgcgc ctggggcggt ggaactcggg gaggagaggg agggatcaga

601 caggagagtg gggactaccc cctctgctcc caaattgggg cagcttcctg ggtttccgat

661 tttctcattt ccgtgggtaa aaaaccctgc ccccaccggg cttacgcaat ttttttaagg

721 ggagaggagg gaaaaaattt gtgggggggt acgaaaaggc ggaaagaaac agtcattcac

781 atgggcttgg ttttcagtct tataaaaagg aaggttctct cggttagcga ccaattgtca

841 tacgacttgc agtgagcgtc aggagcacgt ccaggaactc ctcagcagcg cctccttcag

901 ctccacagcc agacgccctc agacagcaaa gcctaccccc gcgccgcgcc ctgcccgccg

961 ctcggatgct cgcccgcgcc ctgctgctgt gcgcggtcct ggcgctcagc catacaggtg

1021 agtacctggc gccgcgcacc ggggactccg gttccacgca cccgggcaga gtttccgctc

1081 tgacctcctg ggtctatccc agtactccga cttctctccg aatagagaag ctacgtgact

1141 tgggaaagag cttggaccgc tagagtccga aagaactccg tggatattcc agctttccca

1201 caagcactga tcattatgag ccagttactt aaccgatctg agacactctc acctcctaaa

1261 tagggataga tgatactaat ttgcaggttg tcattatgat aagacaggat ctgatcaata

1321 tatgtgaatt gtttatattt ggaacctttt tattgagtgg aagaagttgt tttaaatatt

1381 ctagtcagtt ctttcctgct cccaggaaag cccggattat gttttaagat aagcaaaatg

1441 tcttaaaagt aagctgtttt actttgaatt tttccctaaa tgttgattag tgtactagat

1501 ccattttaat ttggaaagtg aagtgctact tatttgaact tcttaaaaat gctaatttta

1561 acatctaaag agttaactaa gaaaagctta gtaacatgat gtaccaagtt gaatatgctg

1621 ttatccttat ttagaataga aaattggtat ttctacgttt tatccattct aaggcaggtt

1681 aaaaaattgt atttccatga ctacctatat atttcttgaa tttattattg taaagttgat

1741 tcatagtcaa acaattaaat gtttaaatta agattaagac actagagaat gatttatttg

1801 ctgtccttta attgcagcaa atccttgctg ttcccaccca tgtcaaaacc gaggtgtatg

1861 tatgagtgtg ggatttgacc agtataagtg cgattgtacc cggacaggat tctatggaga

1921 aaactgctca acacgtaagt ttgtcctttg gttgcctcat taggagtggg gctggataca

1981 gttatcattg tatagatttg tgtcttataa tgagtcccat taatttctcc ctccctttct

2041 tcgtcttctt gcagcggaat ttttgacaag aataaaatta tttctgaaac ccactccaaa

2101 cacagtgcac tacatactta cccacttcaa gggattttgg aacgttgtga ataacattcc

2161 cttccttcga aatgcaatta tgagttatgt cttgacatgt aagtacaagt gtctttctaa

2221 ggtttttagc cttctcaaag aaaaatatgc tttataatac tgtaagccta atctaaaaac

2281 atatttccaa gcttatcaaa aagactttaa gatagctttt aagtttgcct tccatcttaa

2341 tcgccaaaaa tattgacatt tagtcccatc cagtttatac agtctgctca caactctgta

2401 tacctcttct aacctttact gtttggtcag tttgtggagg tagcatggtc cagctgttta

2461 ttgaatgccc atgggccaca gaattgttct gaacatgtag cacccattaa aataaatttg

2521 gatttggatc agcaagaaaa taactttcca tgattctaaa gtgggtgcca tactcagcca

2581 ttcctttcat aggcctcttg gatagtgagc agatggctac ctgaaaaatc aatattgcca EPI-109 896

2641 gattataatg tgcagagtat atgtatttta ttaaagatgt atttcaagtg gccattagac 2701 tataaagtgt agttgtttaa aaatagattt tttttatttt ggagttacat tcaacctcag 2761 gtgccacttt ccacatttta caataaaaat aatggttgat ttacttaaca aatgagaata 2821 aataaaacat ttttttcttt gaaaatttca gccagatcac atttgattga cagtccacca 2881 acttacaatg ctgactatgg ctacaaaagc tgggaagcct tctctaacct ctcctattat 2941 actagagccc ttcctcctgt gcctgatgat tgcccgactc ccttgggtgt caaaggtgag 3001 taagaagaat ccattagag^'a tgtattaact ataagacggg ctgcattgct gccaaaaaaa 3061 aaaattgacc ttagactacc atttatttat taacaaaagc agtttttact tttagcatgg 3121 ttatctatgg gtatttttta aagtatgagt ctatataaac tattatgtaa aagcaaatga 3181 gcgtcttggt ataatgtctt aatattttca aattatttct ttagaaatga aataattcta 3241 attaaaatag ataaaatcat tcagtaagaa gttgttccac catatcttag aactgttgtt 3301 tatattatga tcctattcac aattgtaatt ctcatataaa tgaagaattc ttggtagatt 3361 gacagtcacc atctcctttc ttgaatacat agatggattc ttaccttagc tttctcattt 3421 ttcaggtaaa aagcagcttc ctgattcaaa tgagattgtg gaaaaattgc ttctaagaag 3481 aaagttcatc cctgatcccc agggctcaaa catgatgttt gcattctttg cccagcactt 3541 cacgcatcag tttttcaaga cagatcataa gcgagggcca gctttcacca acgggctggg 3601 ccatggggta agatagagtt aatatcttag agttagtaaa attataccaa atcatagtca 3661 agggctaaca ttaaaggaga tatacagata gatagatcca aataacttat ccactttttt 3721 taaaaagaag tcttatctat aaaaacctta aaggaatttt ccatttactt cactggtcta 3781 gtaaaattat acacacacac agacatgcac acacatatat aaacattcac acacatacat 3841 atgtacaggt attgttattt gtaatttgac ccttgtattt tttagtttaa aatgttagta 3901 ctgcaaaatg ttatgtcctc aaaaacacat tgtaccatga ttatgccgct ttcaatattg 3961 taaagtgagg tttttgccgc attattattt tttggatttc aatagcatag cttcaagtta 4021 ttcgtaagaa ttttttataa ataatacatt tttatacttt tttataatta ccatatcatc 4081 atagtgaagt atataatata tatgatataa gctcaatata gtatattaat tccgttaaac 4141 acaaagacat atcagtttgt agctttggtg gataaacaaa ttaatttagc aattcatggc 4201 tatgaaaaat gtatatttta tttaaaaatt ttaaagaaag ctaaatgatc aaattattta 4261 atgatgaatt atatgataga cactttatat aagaaaaact tcaacagcaa caaattaaaa 4321 ttttttcatc attttctagg tggacttaaa tcatatttac ggtgaaactc tggctagaca 4381 gcgtaaactg cgccttttca aggatggaaa aatgaaatat caggtatgct tcctttgact 4441 attaagactt agttattacc gcttataccc atattttaaa atccctaaaa atgtgttcct 4501 taacttttta actgatgtt.t atttatttat ttattttttt agataattga tggagagatg 4561 tatcctccca cagtcaaaga tactcaggca gagatgatct accctcctca agtccctgag 4621 catctacggt ttgctgtggg gcaggaggtc tttggtctgg tgcctggtct gatgatgtat 4681 gccacaatct ggctgcggga acacaacaga gtatgcgatg tgcttaaaca ggagcatcct 4741 gaatggggtg atgagcagtt gttccagaca agcaggctaa tactgatagg taaacaagaa 4801 aatgatttat ataaaaccct cttccccagg gaaaattagt gtgctatctt tgttatgttt 4861 tgagtaaatg acaagatgtg gtaaatgaaa actcacacat tctatataca ttaaatatgt 4921 aagcatgact gataaaatag ctatcttttg atactgacaa ggaagaaaac agaaatgaag 4981 gaatagcaaa ttttaaaaat tgcattccag ttgcttgaaa gcttgtgatc agatgcaata 5041 aatgttttta ttatttattt tgtgcaaata ggagagacta ttaagattgt gattgaagat 5101 tatgtgcaac acttgagtgg ctatcacttc aaactgaaat ttgacccaga actacttttc 5161 aacaaacaat tccagtacca aaatcgtatt gctgctgaat ttaacaccct ctatcactgg 5221 catccccttc tgcctgacac ctttcaaatt catgaccaga aatacaacta tcaacagttt 5281 atctacaaca actctatatt gctggaacat ggaattaccc agtttgttga atcattcacc 5341 aggcaaattg ctggcagggt aagcattatt attgaaaacc aaaacaaaag actagtcagt 5401 aactttagaa tttctgccac ggaaattatt tttcttaaac ttactaaaag agtagttagt 5461 tatattgcta gtaaaattat tttattgata taagaagcct aactttgttt gaaaagtcta 5521 aacttttagt ctagtctaca gttgtcagac aaatagcaaa ttgtacccct accttaaaaa 5581 tattttcaaa aagtatctat aatcttatag gaataaatat tttaggcttg aatactagtg 5641 ttatttttga aatgtaaaaa ggcaaattag ttctaggctg gtgtcccatt gaattttaag 5701 cagagctcct gttgaaatgt aggtaagcat ctttccagca aataaaaatt gtctccgctg 5761 ggagtttcag ttttacctga tttgtaccta aggcaagctg aatacaaaca gtaaatatgc 5821 ctaaaattct tgttttacaa ctaattttac tttccacagg ttgctggtgg taggaatgtt 5881 ccacccgcag tacagaaagt atcacaggct tccattgacc agagcaggca gatgaaatac 5941 cagtctttta atgagtaccg caaacgcttt atgctgaagc cctatgaatc atttgaagaa 6001 cttacaggta agaaacagtt tctaaacttc ttcgtttttt gtttgtttgt ttgtttttgt 6061 tgtttttggt tttcttttcg agatggagcc gccctctgtc acccaggctg gagtgcagtg 6121 gcgccatctc ggctcactgc aacctccgcc tcctgggttc aagcaattct cctgcctcaa 6181 cttcctgagt agctgggact acaggctcac gtcgcacgca tggataattt tttgtatttt 6241 cagtatagac ggggtttcac cgtgttagcc aggctggtct caaactcctg acctagtgat 6301 ccgccggctt cggcctcccg aagtgctggg attacaggcg tgagccaccg cgcctggccc 6361 ctaaacttct taaaagaatc aggggtcaaa tggaaacaga gaagttggca gcaaattgag 6421 caaaagaatc aaactgtttt ttattttgtg aagtttgaca ttggttgtat ctctgtcttc 6481 atcgccttca caggagaaaa ggaaatgtct gcagagttgg aagcactcta tggtgacatc 6541 gatgctgtgg agctgtatcc tgcccttctg gtagaaaagc ctcggccaga tgccatcttt 6601 ggtgaaacca tggtagaagt tggagcacca ttctccttga aaggacttat gggtaatgtt 6661 atatgttctc ctgcctactg gaagccaagc acttttggtg gagaagtggg ttttcaaatc EPI-109 897

6721 atcaacactg cctcaattca gtctctcatc tgcaataacg tgaagggctg tccctttact

6781 tcattcagtg ttccagatcc agagctcatt aaaacagtca ccatcaatgc aagttcttcc

6841 cgctccggac tagatgatat caatcccaca gtactactaa aagaacgttc gactgaactg

6901 tagaagtcta atgatcatat ttatttattt atatgaacca tgtctattaa tttaattatt

6961 taataatatt tatattaaac tccttatgtt acttaacatc ttctgtaaca gaagtcagta

7021 ctcctgttgc ggagaaagga gtcatacttg tgaagacttt tatgtcacta ctctaaagat

7081 tttgctgttg ctgttaagtt tggaaaacag tttttattct gttttataaa ccagagagaa

7141 atgagttttg acgtcttttt acttgaattt caacttatat tataagaacg aaagtaaaga

7201 tgtttgaata cttaaacact atcacaagat ggcaaaatgc tgaaagtttt tacactgtcg

7261 atgtttccaa tgcatcttcc atgatgcatt agaagtaact aatgtttgaa attttaaagt

7321 acttttggtt atttttctgt catcaaacaa aaacaggtat cagtgcatta ttaaatgaat

7381 atttaaatta gacattacca gtaatttcat gtctactttt taaaatcagc aatgaaacaa

7441 taatttgaaa tttctaaatt catagggtag aatcacctgt aaaagcttgt ttgatttctt

7501 aaagttatta aacttgtaca tataccaaaa agaagctgtc ttggatttaa atctgtaaaa

7561 tcagatgaaa ttttactaca attgcttgtt aaaatatttt ataagtgatg ttcctttttc

7621 accaagagta taaacctttt tagtgtgact gttaaaactt ccttttaaat caaaatgcca

7681 aatttattaa ggtggtggag ccactgcagt gttatctcaa aataagaata ttttgttgag

7741 atattccaga atttgtttat atggctggta acatgtaaaa tctatatcag caaaagggtc

7801 tacctttaaa ataagcaata acaaagaaga aaaccaaatt attgttcaaa tttaggttta

7861 aacttttgaa gcaaactttt ttttatcctt gtgcactgca ggcctggtac tcagattttg

7921 ctatgaggtt aatgaagtac caagctgtgc ttgaataacg atatgttttc tcagattttc

7981 tgttgtacag tttaatttag cagtccatat cacattgcaa aagtagcaat gacctcataa

8041 aatacctctt caaaatgctt aaattcattt cacacattaa ttttatctca gtcttgaagc

8101 caattcagta ggtgcattgg aatcaagcct ggctacctgc atgctgttcc ttttcttttc

8161 ttcttttagc cattttgcta agagacacag tcttctcatc acttcgtttc tcctattttg

8221 ttttactagt tttaagatca gagttcactt tctttggact ctgcctatat tttcttacct

8281 gaacttttgc aagttttcag gtaaacctca gctcaggact gctatttagc tcctcttaag

8341 aagattaaaa gagaaaaaaa aaggcccttt taaaaatagt atacacttat tttaagtgaa

8401 aagcagagaa ttttatttat agctaatttt agctatctgt aaccaagatg gatgcaaaga

8461 ggctagtgcc tcagagagaa ctgtacgggg tttgtgactg gaaaaagtta cgttcccatt

8521 ctaattaatg ccctttctta tttaaaaaca aaaccaaatg atatctaagt agttctcagc

8581 aataataata atgacgataa tacttctttt ccacatctca ttgtcactga catttaatgg

8641 tactgtatat tacttaattt attgaagatt attatttatg tcttattagg acactatggt

8701 tataaactgt gtttaagcct acaatcattg attttttttt gttatgtcac aatcagtata

8761 ttttctttgg ggttacctct ctgaatatta tgtaaacaat ccaaagaaat gattgtatta

8821 agatttgtga ataaattttt agaaatctga ttggcatatt gagatattta aggttgaatg

8881 tttgtcctta ggataggcct atgtgctagc ccacaaagaa tattgtctca ttagcctgaa

8941 tgtgccataa gactgacctt ttaaaatgtt ttgagggatc tgtggatgct tcgttaattt

9001 gttcagccac aatttattga gaaaatattc tgtgtcaagc actgtgggtt ttaatatttt

9061 taaatcaaac gctgattac^'a gataatagta tttatataaa taattgaaaa aaattttctt

9121 ttgggaagag ggagaaaatg aaataaatat cattaaagat aactcaggag aatcttcttt

9181 acaattttac gtttagaatg tttaaggtta agaaagaaat agtcaatatg cttgtataaa

9241 acactgttca ctgttttttt taaaaaaaaa acttgatttg ttattaacat tgatctgctg

9301 acaaaacctg ggaatttggg ttgtgtatgc gaatgtttca gtgcctcaga caaatgtgta

9361 tttaacttat gtaaaagata agtctggaaa taaatgtctg tttatttttg tactatttaa

9421 aaaaaaaaaa aaaaatcgat gtcgactcga gtc

(2) INFORMATION FOR SEQ ID NO: 2685: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2685

1 gaattccgga gttccgggcg cgcgcgacgt cagtttgagt tctgtgttct ccccgcccgt

61 gtcccgcccg acccgcgccc gcgatgctgg cgctgcgctg cggctcccgc tggctcggcc

121 tgctctccgt cccgcgctcc gtgccgctgc gcctccccgc ggcccgcgcc tgcagcaagg

181 gctccggcga cccgtcctct tcctcctcct ccgggaaccc gctcgtgtac ctggacgtgg

241 acgccaacgg gaagccgctc ggccgcgtgg tgctggagct gaaggcagat gtcgtcccaa

301 agacagctga gaacttcaga gccctgtgca ctggtgagaa gggcttcggc tacaaaggct

361 ccaccttcca cagggtgatc ccttccttca tgtgccaggc gggcgacttc accaaccaca

421 atggcacagg cgggaagtcc atctacggaa gccgctttcc tgacgagaac tttacactga

481 agcacgtggg gccaggtgtc ctgtccatgg ctaatgctgg tcctaacacc aacggctccc

541 agttcttcat ctgcaccata aagacagact ggttggatgg caagcatgtt gtgttcggtc

601 acgtcaaaga gggcatggac gtcgtgaaga aaatagaatc tttcggctct aagagtggga

661 ggacatccaa gaagattgtc atcacagact gtggccagtt gagctaatct gtggccaggg

721 tgctggcatg gtggcagctg caaatgtcca tgcacccagg tggccgcgtt gggctgtcag

781 ccaaggtgcc tgaaacgata cgtgtgccca ctccactgtc acagtgtgcc tgaggaaggc EPI-109 898

841 tgctagggat gttagacgga attcc

(2) INFORMATION FOR SEQ ID NO: 2686: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2686 1 ttttgcagac gccaccgccg aggaaaaccg tgtactatta gccatggtc

(2) INFORMATION FOR SEQ ID NO:2687: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2687

1 cgggaacgca acatgaaggt gctccttgcc gccgccctca tcgcggggtc cgtcttcttc

61 ctgctgctgc cgggaccttc tgcggccgat gagaagaaga aggggcccaa agtcaccgtc

121 aaggtgtatt ttgacctacg aattggagat gaagatgtag gccgggtgat ctttggtctc

181 ttcggaaaga ctgttccaaa aacagtggat aattttgtgg ccttagctac aggagagaaa

241 ggatttggct acaaaaacag caaattccat cgtgtaatca aggacttcat gatccagggc

301 ggagacttca ccaggggaga tggcacagga ggaaagagca tctacggtga gcgcttcccc

361 gatgagaact tcaaactgaa gcactacggg cctggctggg tcagcatggc caacgcaggc

421 aaagacacca acggctccca gttcttcatc acgacagtca agacagcctg gctagatggc

481 aagcatgtgg tgtttggcaa agttctagag ggcatggagg tggtgcggaa ggtggagagc

541 accaagacag acagccggga taaacccctg aaggatgtga tcatcgcaga ctgcggcaag

601 atcgaggtgg agaagccctt tgccatcgcc aaggagtagg gcacagggac atctttcttt

661 gagtgaccgt ctgtgcaggc cctgtagtcc gccacagggc tctgagctgc actggccccg

721 gtgctggcat ctggtggagc ggacccactc ccctcacatt ccacaggccc atggactcac

781 ttttgtaaca aactcctacc aacactgacc aataaaaaaa aatgtgggtt tttttttttt

841 ttaataaaaa a

(2) INFORMATION FOR SEQ ID NO: 2688: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2688

1 gaaggtgctc cttgccgccg ccctcatcgc ggggtccgtc ttcttcctgc tgctgccggg

61 accttctgcg gccgatgaga agaagaaggg gcccaaagtc accgtcaagg tgtattttga

121 cctacgaatt ggagatgaag atgtaggccg ggtgatcttt ggtctctttg gaaagactgt

181 tccaaaaaca gtggataatt ttgtggcctt agctacagga gagaaaggat ttggctacaa

241 aaacagcaaa ttccatcgtg taatcaagga cttcatgatc cagggcggag acttcaccag

301 gggagatggc acaggaggaa agagcatcta cggtgagcgc ttccccgatg agaacttcaa

361 actgaagcac tacgggcctg gctgggtgag catggccaac gcaggcaaag acaccaacgg

421 ctcccagttc ttcatcacga cagtcaagac agcctggcta gatggcaagc atgtggtgtt

481 tggcaaagtt ctagagggca tggaggtggt gcggaaggtg gagagcacca agacagacag

541 ccgggataaa cccctgaagg atgtgatcat cgcagactgc ggcaagatcg aggtggagaa

601 gccctttgcc atcgccaagg agtagggcac agggacatct ttctttgagt gaccgtctgt

661 gcaggccctg tagtccgcca cagggctctg agctgcactg gccccggtgc tggcatctgg

721 tggagcggac ccactcccct cacattccac aggcccatgg actcactttt gtaacaaact

781 cctaccaaca ctgaccaata aaaaaaaatg tgggtttttt tttttaataa aag

(2) INFORMATION FOR SEQ ID NO: 2689: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO.-2689

1 gaattccctt gtaaggtttt cttaacaaaa caccagtcac ataagtgcat tttattttat

61 atttttgttt atttatttga gacggagtct cttgtctctc aggctggagt gcagtggcgc

121 catctctgct cgctgcaacc tccacctcct gggttccagc gattctcctg cctcagcctc

181 ccgagggggt agctgggact acaggtgcgc accaccatgc ccagctaatt ttgtattttt

241 cgtagagatg gggtttcacc atgttgtcca ggctggtctt gaactcctga cctcaggtga

301 tcctcccgcc tcggcctccc aaagtgctgg aattacaggc gtgatccacc gcacccggcc

361 tattttttga gagagggtca cactctgtcg tcccggctgg aatgcagtga tgcgatcacc EPI-109 899

421 gcccactaca gcctcgacct ccgggctcaa gcaatcctcc ccgcccagcc tcctgagtag

481 cgagcgcctc gacgcccagc taatttttat ttttatttat ttttttgtag agacggcgtc

541 tctctaagat gcccaggctg gtggccggtg tcgaactcct aagatgaagc gatcctcccc

601 ggccttggcc tccgcgcctc ctaaagcgcc aggtatgagc caccgcgcct ggcctacaag

661 tgcattttaa ttaaagtatt attaatgtct ttgcctgaag aaattcgctt ttaaattgtg

721 acttatcttt cacccaaaaa tcaaagcaca attcagcccc gaggcggggg cggtaggagc

781 tgggcggggc gggggcaggg aaagaccagg agcagagatt caaaaagagt aagagggcaa

841 aatgtgcata atgcatcttc acaggtaaga gcctggccag gctcctgttt taatggcttc

901 ctcctgaaga agattcaagc agagtgtaag atattttcgg aaagtagagc attttgaaag

961 catttcataa tctctcaaaa ccggagactg ctcctgtccc acctcgttag agaaaacagc

1021 gatgctcaaa ggcaacctcc ttcctgacat tgcctggtag gacgcgacgt ggtgtttgcc

1081 cgcgcggaat gcggacgcaa ggctgctcct aggtctcggg gacgcgccat ccccatttcc

1141 gctcgcggag gcgtagggtc cgggcgcggg accccagtcg accttgactg gcggcgcgac

1201 cttgaggcct gcgttcgcct cagttgcccc ctctgtgcaa tggggagacg cgcctcatcg

1261 cttgacaacg gccgaagagc cgccgcgctt ccgtctcccg cgtgcgcgcg ccatgctgcc

1321 cacccccgtt ccgcactgac cctcccccgt gccccgcgtc ccgtactgcc gccccgcccc

1381 gagtcccatg ccgcagccac cgcgacggag cccgcaggcg ggaacctgcc tccgcgcgtt

1441 agcgcgcacg cgcgcctcat gtgtcgtccc catcagcgcc ggcttccgtc tataggccag

1501 atgcactgtc actctggcga agtcgcagac ccgattggcc gggacggagg cgcgagaccg

1561 ggttgcgggc ggggccgaac gtggtataaa acgggcggga ggccaggctc gtgccgtttt

1621 gcagacgcca ccgccgagga aaaccgtgta ctattagcca tggtcaaccc caccgtgttc

1681 ttcgacattg ccgtcgacgg cgagcccttg ggccgcgtct cctttgaggt cgggcgggcg

1741 gcggcgtgcg ggaatggggc ccagaaagtg ggccggggtc ggggtgggtg gtagcgcccc

1801 aaaggcccgg gcgcggggcg accctgcttg aggggcgagc gcgggcgggc tgcggcgcca

1861 tttcctgacg aggggccatt ttgggaggtc cgcgagtcgc gggaggaggc cgggacgcgg

1921 cggacaaagg caggcggggc ggctgcgagg ccgttggggg agggggcccg cgtccgcccg

1981 cccgcctcat gtggccgcgc cctgtcctgt ccgacgcacg tgctcggcgg ccgcgctcag

2041 gtccgcgcct tgagagtcgt tgtccgccct agcttggcct gggcgccgca gaccggagcc

2101 agaagcacgc tcgcgggggc ttgcgaccgc cttcctggga agctgtcccc tggcaggcat

2161 gggtgcttta catcctgagc tgggaagctg tttgcttgag ggtttttctc aaggatcgag

2221 gcgcggtgtg agcccgtcca tgctcggtcc tgtagatccc gggaggccat gttataaaag

2281 gagacttgct gggatgtgac gggttgccac ttgaaatatc ttccatttgg ataaagtagg

2341 aatatttata catgtgcccc aaacgtccct ccgtgtcccc cacccccaag cggaaatgtg

2401 aaaatgggcc ttgcctttgc tggtgcccaa ggaccgcctt ccactgcagt gacggcgctg

2461 gcgggggagg cgctcttgag cccctcccga ttgtccctct gcctagcaag caagttgcga

2521 ctggccacaa ggcaggcctc ttccgaccaa ggtggattac cagtgattac ctaattagtt

2581 ttgagagcgt taaatgagtt cttaaagatc agttgtaatt atagcatagt atctaaactt

2641 ggcgcgtgtc ttcaaagtta aatattgagt acgattccgt tccagttaac atggatagac

2701 cttagggagt agcgaaatag gatgttagtg gttttattcc tttaaatcac atctcaaaag

2761 gccaccaatg gctagtttgg atcttattcc gaaaatagat tgatcctcat gcagtcttcg

2821 tgaggacaga gcgatttcct tgttgcctac cctgtccata gtgcctggca cataggcact

2881 gaaacactgc atgttaatcc acaccccacc ccacctatga gtgtagtcaa agctggtaag

2941 tgacaagggc tttcgtggaa acttggcctg acctaatgtt gggcatcagg ttacccaaag

3001 agcttcaggg aaatgagaaa ggacttgcag gtcttgatga gaatggaggg gtaactgcca

3061 atgagggctt tggctttagc gaaagtctga aagggaagcc ataggaactt aaacgtaccg

3121 actataaagc tctgagaaaa gctgatgttt tagaaagacc atacattcta ggtacaaata

3181 cctaaaaact aaaaaataag tacgttggcc aggcgggcgg atcacgaagt caggagattg

3241 agaccatcct gggcccctgg tgaaacccca cctctattaa aaatacaaaa attagctggg

3301 cgtggtggcg cttgcctgta atctcagcta ctctagaggc tgaggcagga gatcgcttga

3361 accccggagg cggaggctgc agtgagccga gatcgtgcca ctgcactcca gcctggtgac

3421 agcgagactc ttgtctcaaa aaaaaaaaag tacattgcta taagagaagt gcacacggat

3481 actagtagtt aattcagtca catctgtgaa atagcttata aaatgctact tttaaacaag

3541 ctgtttttat gaaagggctt gtaaatgttt atggtattta agctacctct ctagccataa

3601 cgtattatac attcaagaaa ggttcaaaac cagatatact agaaaccaat ctttattttt

3661 taccccacta ctaggtaagg gcctggatac caagaagtga ctgctcatct aatccataaa

3721 gctatgttaa cagattggag gtagtagcat tttcattaca agtgactaaa agaacagctg

3781 tttacccctg atcgtgcagc agtgcttgct gttccttaga attttgcctt gtaagttcta

3841 gctcaagttg gggggtggtg atagacattt aagaagccat atatcttttc agaagtaggt

3901 gtgatgtact aaaagtttga gacactttct agaagtctca ctatttaagt tatgactagt

3961 attggatttt tggcatgtct ttgggtttca tgtttcttaa cccaactgcc tgcagggcct

4021 tatggctgtc aggagcagtt cttgggaatt aaagtaatta ctgaagaagt attctagtga

4081 gaaaatgaat ttatgactca gaagccccta aagacatggg tactaagcaa caaaataagc

4141 agatgttaat taactgtaat tttctcttac agctgtttgc agacaaggtc ccaaagacag

4201 caggttggtc cattttctaa gtttaacaaa gatgttccaa ttgtgacagt ttgtgtgtgt

4261 gtgtgtatat atatattttt atgtatgtat atatgtgttt aatttttttt taaacagaaa

4321 attttcgtgc tctgagcact ggagagaaag gatttggtta taagggttcc tgctttcaca

4381 gaattattcc agggtttatg tgtcaggtac gaaatttact gaattttatt ttatttgggt

4441 tgctcccttc atttgggatt gagccagaat atttcaggat acacatatct gaactgttac EPI-109 900

4501 tctaccattt cggttctatt taacccttct attcagtttg aacttgggtt taaagtttga 4561 accttgcaga tttggcacac ttcatggtta tgttgtcaga agtgacattt ttcctatatg 4621 ttgacagggt ggtgacttca cacgccataa tggcactggt ggcaagtcca tctatgggga 4681 gaaatttgaa gatgagaact tcatcctaaa gcatacgggt cctggcatct tgtccatggc 4741 aaatgctgga cccaacacaa atggttccca gtttttcatc tgcactgcca agactgagtg 4801 gtaagggtac aacatggcac actaaccacc tgactaaatg aaaagttgcc ctggggggaa 4861 cggaacaaac actacttttc ttcaaccttt gcttccacag actttttcat ccctaagata 4921 ctagaagaag agcatacata aatgacaaat atagccaatg tgatacagaa tgtcagatac 4981 tatgatagaa acttggccct tagctgggtg gttgaattag gtgctacttt tttgagatgg 5041 agttttgctc tgttgccagg ttggagtgca gtggcacaat ctgggctcac tgcaacctct 5101 gcctcctggg ttcaagcgat tctcctgcct tggcctcctg agtagctgag aatacagatg 5161 tgtgccagca tgcctggcta attttttgta tttttgtgga gacggggttt catcatgttg 5221 gccaagctgg tcttgaactc gtgacttaag gtgaaccacc tgccttggcc ccccaaagtg 5281 ctgggatttc aggcatgagc cactgcgccc aaccaattaa gtgctttttt tttttttttt 5341 cttttctcag actggatctc gctcttatct cccaggttgg agtgcagtgg tgccatctca 5401 gctcactgca acctcctccc gggttcaagc aattcttctg cctcagcctc tcaagtagct 5461 ggaactacag gcatgcacca ccactcccag ctaaattgtg tattattagt agagcgggat 5521 ttaccatgtt gtccaggctg gtctcgaact cctgggctca agtgatctgc ctgccttgac 5581 ccccccgaag tgctgggatt acaggcatga gccactgtgc ccacccaatt aagtgctgct 5641 tttatgttac tattaataac atgcggttgg ttgggttttt tgtttctttg gggtttttgt 5701 tttgttttgt ttgtttttgg gggagggggg cgcaattcat tctatatgtg taactctttt 5761 ttgagatgga gtttcgctct gtcgcccagg ctggagtgca gtggcgcgat ctcggctcac 5821 tgcaagctcc gcctcccagg ttcacgccat tctcctgcct cagcctcccg agtagctggg 5881 actataggca catgccacca tgcccggcta attttttgta tttttagtag agacagggtt 5941 tcaccgtgtt agccaggatg gtctcgatct cctgacctcg tgatccgccc gccttggcct 6001 cccaaagtgc tgggattaca ggcgtgagcc accgcacccg gcctatatgt gtaactcttt 6061 aatggtaatt ggagaatcat gtttaatgac atttagtaca aaaggcttca gttaaaaaaa 6121 aaaaaaaaaa gctacctttc tcgtcttggt tcatgacaca tggaggctgc ttgtttgtgg 6181 ttgccagtca taatgattgt tcttcctttt caaggttgga tggcaagcat gtggtgtttg 6241 gcaaagtgaa agaaggcatg aatattgtgg aggccatgga gcgctttggg tccaggaatg 6301 gcaagaccag caagaagatc accattgctg actgtggaca actcgaataa gtttgacttg 6361 tgttttatct taaccaccag atcattcctt ctgtagctca ggagagcacc cctccacccc 6421 atttgctcgc agtatcctag aatctttgtg ctctcgctgc agttcccttt gggttccatg 6481 ttttccttgt tccctcccat gcctagctgg attgcagagt taagtttatg attatgaaat 6541 aaaaactaaa taacaattgt cctcgtttga gttaagtgtt gatgtaggct ttattttaag 6601 cagtaatggg ttacttctga aacatcactt gtttgcttaa ttctacacag tacttagatt 6661 ttttttactt tccagtccca ggaagtgtca atgtttgttg agtggaatat t

(2) INFORMATION FOR SEQ ID NO:2690: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO 26gθ 1 gtgtactatt agccatggtc aaccccaccg tgttcttcga cattgccgtc gacggcgagc 61 ccttgggccg cgtctccttt gagctgtttg cagacaaggt cccaaagaca gcagaaaatt 121 ttcgtgctct gagcactgga gagaaaggat ttggttataa gggttcctgc tttcacagaa 181 ttattccagg gtttatgtgt cagggtggtg acttcacacg ccataatggc actggtggca 241 agtccatcta tggggagaaa tttgaagatg agaacttcat cctaaagcat acgggtcctg 301 gcatcttgtc catggcaaat gctggaccca acacaaatgg ttcccagttt ttcatctgca 361 ctgccaagac tgagtggttg gatggcaagc atgtggtgtt tggcaaagtg aaagaaggca 421 tgaatattgt ggaggccatg gagcgctttg ggtccaggaa tggcaagacc agcaagaaga 481 tcaccattgc tgactgtgga caactcgaat aagtttgact tgtgttttat cttaaccacc 541 agatcattcc ttctgtagct caggagagca cccctccacc ccatttgctc gcagtatcct 601 agaatctttg tgctctcgct gcagttccct ttgggttcca tgttttcctt gttccctccc 661 atgcctagct ggattgcaga gttaagttta tgattatgaa ataaaaacta aataacaatt 721 gtc

>) INFORMATION FOR SEQ ID NO: 2691: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ Dase pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi)SEQUENCE DESCRIPTION: SEQ ID NO:2691

1 gaattccgga gttccgggcg cgcgcgacgt cagtttgagt tctgtgttct ccccgcccgt

61 gtcccgcccg acccgcgccc gcgatgctgg cgctgcgctg cggctcccgc tggctcggcc

121 tgctctccgt cccgcgctcc gtgccgctgc gcctccccgc ggcccgcgcc tgcagcaagg EPI-109 901

181 gctccggcga cccgtcctct tcctcctcct ccgggaaccc gctcgtgtac ctggacgtgg

241 acgccaacgg gaagccgctc ggccgcgtgg tgctggagct gaaggcagat gtcgtcccaa

301 agacagctga gaacttcaga gccctgtgca ctggtgagaa gggcttcggc tacaaaggct

361 ccaccttcca cagggtgatc ccttccttca tgtgccaggc gggcgacttc accaaccaca

421 atggcacagg cgggaagtcc atctacggaa gccgctttcc tgacgagaac tttacactga

481 agcacgtggg gccaggtgtc ctgtccatgg ctaatgctgg tcctaacacc aacggctccc

541 agttcttcat ctgcaccata aagacagact ggttggatgg caagcatgtt gtgttcggtc

601 acgtcaaaga gggcatggac gtcgtgaaga aaatagaatc tttcggctct aagagtggga

661 ggacatccaa gaagattgtc atcacagact gtggccagtt gagctaatct gtggccaggg

721 tgctggcatg gtggcagctg caaatgtcca tgcacccagg tggccgcgtt gggctgtcag

781 ccaaggtgcc tgaaacgata cgtgtgccca ctccactgtc acagtgtgcc tgaggaaggc

841 tgctagggat gttagacgga attcc

1 ttttgcagac gccaccgccg aggaaaaccg tgtactatta gccatggtc

1 cgggaacgca acatgaaggt gctccttgcc gccgccctca tcgcggggtc cgtcttcttc

61 ctgctgctgc cgggaccttc tgcggccgat gagaagaaga aggggcccaa agtcaccgtc

121 aaggtgtatt ttgacctacg aattggagat gaagatgtag gccgggtgat ctttggtctc

181 ttcggaaaga ctgttccaaa aacagtggat aattttgtgg ccttagctac aggagagaaa

241 ggatttggct acaaaaacag caaattccat cgtgtaatca aggacttcat gatccagggc

301 ggagacttca ccaggggaga tggcacagga ggaaagagca tctacggtga gcgcttcccc

361 gatgagaact tcaaactgaa gcactacggg cctggctggg tcagcatggc caacgcaggc

421 aaagacacca acggctccca gttcttcatc acgacagtca agacagcctg gctagatggc

481 aagcatgtgg tgtttggcaa agttctagag ggcatggagg tggtgcggaa ggtggagagc

541 accaagacag acagccggga taaacccctg aaggatgtga tcatcgcaga ctgcggcaag

601 atcgaggtgg agaagccctt tgccatcgcc aaggagtagg gcacagggac atctttcttt

661 gagtgaccgt ctgtgcaggc cctgtagtcc gccacagggc tctgagctgc actggccccg

721 gtgctggcat ctggtggagc ggacccactc ccctcacatt ccacaggccc atggactcac

781 ttttgtaaca aactcctacc aacactgacc aataaaaaaa aatgtgggtt tttttttttt

841 ttaataaaaa a

1 gaaggtgctc cttgccgccg ccctcatcgc ggggtccgtc ttcttcctgc tgctgccggg

61 accttctgcg gccgatgaga agaagaaggg gcccaaagtc accgtcaagg tgtattttga

121 cctacgaatt ggagatgaag atgtaggccg ggtgatcttt ggtctctttg gaaagactgt

181 tccaaaaaca gtggataatt ttgtggcctt agctacagga gagaaaggat ttggctacaa

241 aaacagcaaa ttccatcgtg taatcaagga cttcatgatc cagggcggag acttcaccag

301 gggagatggc acaggaggaa agagcatcta cggtgagcgc ttccccgatg agaacttcaa

361 actgaagcac tacgggcctg gctgggtgag catggccaac gcaggcaaag acaccaacgg

421 ctcccagttc ttcatcacga cagtcaagac agcctggcta gatggcaagc atgtggtgtt

481 tggcaaagtt ctagagggca tggaggtggt gcggaaggtg gagagcacca agacagacag

541 ccgggataaa cccctgaagg atgtgatcat cgcagactgc ggcaagatcg aggtggagaa

601 gccctttgcc atcgccaagg agtagggcac agggacatct ttctttgagt gaccgtctgt

661 gcaggccctg tagtccgcca cagggctctg agctgcactg gccccggtgc tggcatctgg

721 tggagcggac ccactcccct cacattccac aggcccatgg actcactttt gtaacaaact

781 cctaccaaca ctgaccaata aaaaaaaatg tgggtttttt tttttaataa aag

1 gaattccctt gtaaggtttt cttaacaaaa caccagtcac ataagtgcat tttattttat

61 atttttgttt atttatttga gacggagtct cttgtctctc aggctggagt gcagtggcgc

121 catctctgct cgctgcaacc tccacctcct gggttccagc gattctcctg cctcagcctc

181 ccgagggggt agctgggact acaggtgcgc accaccatgc ccagctaatt ttgtattttt

241 cgtagagatg gggtttcacc atgttgtcca ggctggtctt gaactcctga cctcaggtga

301 tcctcccgcc tcggcctccc aaagtgctgg aattacaggc gtgatccacc gcacccggcc

361 tattttttga gagagggtca cactctgtcg tcccggctgg aatgcagtga tgcgatcacc

421 gcccactaca gcctcgacct ccgggctcaa gcaatcctcc ccgcccagcc tcctgagtag

481 cgagcgcctc gacgcccagc taatttttat ttttatttat ttttttgtag agacggcgtc

541 tctctaagat gcccaggctg gtggccggtg tcgaactcct aagatgaagc gatcctcccc

601 ggccttggcc tccgcgcctc ctaaagcgcc aggtatgagc caccgcgcct ggcctacaag

661 tgcattttaa ttaaagtatt attaatgtct ttgcctgaag aaattcgctt ttaaattgtg

721 acttatcttt cacccaaaaa tcaaagcaca attcagcccc gaggcggggg cggtaggagc

781 tgggcggggc gggggcaggg aaagaccagg agcagagatt caaaaagagt aagagggcaa

841 aatgtgcata atgcatcttc acaggtaaga gcctggccag gctcctgttt taatggcttc gθl ctcctgaaga agattcaagc agagtgtaag atattttcgg aaagtagagc attttgaaag

961 catttcataa tctctcaaaa ccggagactg ctcctgtccc acctcgttag agaaaacagc

1021 gatgctcaaa ggcaacctcc ttcctgacat tgcctggtag gacgcgacgt ggtgtttgcc

1081 cgcgcggaat gcggacgcaa ggctgctcct aggtctcggg gacgcgccat ccccatttcc

1141 gctcgcggag gcgtagggtc cgggcgcggg accccagtcg accttgactg gcggcgcgac

1201 cttgaggcct gcgttcgcct cagttgcccc ctctgtgcaa tggggagacg cgcctcatcg

1261 cttgacaacg gccgaagagc cgccgcgctt ccgtctcccg cgtgcgcgcg ccatgctgcc

1321 cacccccgtt ccgcactgac cctcccccgt gccccgcgtc ccgtactgcc gccccgcccc

1381 gagtcccatg ccgcagccac cgcgacggag cccgcaggcg ggaacctgcc tccgcgcgtt

1441 agcgcgcacg cgcgcctcat gtgtcgtccc catcagcgcc ggcttccgtc tataggccag

1501 atgcactgtc actctggcga agtcgcagac ccgattggcc gggacggagg cgcgagaccg EPI-109 902

1561 ggttgcgggc ggggccgaac gtggtataaa acgggcggga ggccaggctc gtgccgtttt

1621 gcagacgcca ccgccgagga aaaccgtgta ctattagcca tggtcaaccc caccgtgttc

1681 ttcgacattg ccgtcgacgg cgagcccttg ggccgcgtct cctttgaggt cgggcgggcg .

1741 gcggcgtgcg ggaatggggc ccagaaagtg ggccggggtc ggggtgggtg gtagcgcccc

1801 aaaggcccgg gcgcggggcg accctgcttg aggggcgagc gcgggcgggc tgcggcgcca

1861 tttcctgacg aggggccatt ttgggaggtc cgcgagtcgc gggaggaggc cgggacgcgg

1921 cggacaaagg caggcgg gc ggctgcgagg ccgttggggg agggggcccg cgtccgcccg

1981 cccgcctcat gtggccgcgc cctgtcctgt ccgacgcacg tgctcggcgg ccgcgctcag

2041 gtccgcgcct tgagagtcgt tgtccgccct agcttggcct gggcgccgca gaccggagcc

2101 agaagcacgc tcgcgggggc ttgcgaccgc cttcctggga agctgtcccc tggcaggcat

2161 gggtgcttta catcctgagc tgggaagctg tttgcttgag ggtttttctc aaggatcgag

2221 gcgcggtgtg agcccgtcca tgctcggtcc tgtagatccc gggaggccat gttataaaag

2281 gagacttgct gggatgtgac gggttgccac ttgaaatatc ttccatttgg ataaagtagg

2341 aatatttata catgtgcccc aaacgtccct ccgtgtcccc cacccccaag cggaaatgtg

2401 aaaatgggcc ttgcctttgc tggtgcccaa ggaccgcctt ccactgcagt gacggcgctg

2461 gcgggggagg cgctcttgag cccctcccga ttgtccctct gcctagcaag caagttgcga

2521 ctggccacaa ggcaggcctc ttccgaccaa ggtggattac cagtgattac ctaattagtt

2581 ttgagagcgt taaatgagtt cttaaagatc agttgtaatt atagcatagt atctaaactt

2641 ggcgcgtgtc ttcaaagtta aatattgagt acgattccgt tccagttaac atggatagac

2701 cttagggagt agcgaaatag gatgttagtg gttttattcc tttaaatcac atctcaaaag

2761 gccaccaatg gctagtttgg atcttattcc gaaaatagat tgatcctcat gcagtcttcg

2821 tgaggacaga gcgatttcct tgttgcctac cctgtccata gtgcctggca cataggcact

2881 gaaacactgc atgttaatcc acaccccacc ccacctatga gtgtagtcaa agctggtaag

2941 tgacaagggc tttcgtggaa acttggcctg acctaatgtt gggcatcagg ttacccaaag

3001 agcttcaggg aaatgagaaa ggacttgcag gtcttgatga gaatggaggg gtaactgcca

3061 atgagggctt tggctttag.c gaaagtctga aagggaagcc ataggaactt aaacgtaccg

3121 actataaagc tctgagaaaa gctgatgttt tagaaagacc atacattcta ggtacaaata

3181 cctaaaaact aaaaaataag tacgttggcc aggcgggcgg atcacgaagt caggagattg

3241 agaccatcct gggcccctgg tgaaacccca cctctattaa aaatacaaaa attagctggg

3301 cgtggtggcg cttgcctgta atctcagcta ctctagaggc tgaggcagga gatcgcttga

3361 accccggagg cggaggctgc agtgagccga gatcgtgcca ctgcactcca gcctggtgac

3421 agcgagactc ttgtctcaaa aaaaaaaaag tacattgcta taagagaagt gcacacggat

3481 actagtagtt aattcagtca catctgtgaa atagcttata aaatgctact tttaaacaag

3541 ctgtttttat gaaagggctt gtaaatgttt atggtattta agctacctct ctagccataa

3601 cgtattatac attcaagaaa ggttcaaaac cagatatact agaaaccaat ctttattttt

3661 taccccacta ctaggtaagg gcctggatac caagaagtga ctgctcatct aatccataaa

3721 gctatgttaa cagattggag gtagtagcat tttcattaca agtgactaaa agaacagctg

3781 tttacccctg atcgtgcagc agtgcttgct gttccttaga attttgcctt gtaagttcta

3841 gctcaagttg gggggtggtg atagacattt aagaagccat atatcttttc agaagtaggt

3901 gtgatgtact aaaagtttga gacactttct agaagtctca ctatttaagt tatgactagt

3961 attggatttt tggcatgtct ttgggtttca tgtttcttaa cccaactgcc tgcagggcct

4021 tatggctgtc aggagcagtt cttgggaatt aaagtaatta ctgaagaagt attctagtga

4081 gaaaatgaat ttatgactca gaagccccta aagacatggg tactaagcaa caaaataagc

4141 agatgttaat taactgtaat tttctcttac agctgtttgc agacaaggtc ccaaagacag

4201 caggttggtc cattttctaa gtttaacaaa gatgttccaa ttgtgacagt ttgtgtgtgt

4261 gtgtgtatat atatattttt atgtatgtat atatgtgttt aatttttttt taaacagaaa

4321 attttcgtgc tctgagcact ggagagaaag gatttggtta taagggttcc tgctttcaca

4381 gaattattcc agggtttatg tgtcaggtac gaaatttact gaattttatt ttatttgggt

4441 tgctcccttc atttgggatt gagccagaat atttcaggat acacatatct gaactgttac

4501 tctaccattt cggttctatt taacccttct attcagtttg aacttgggtt taaagtttga

4561 accttgcaga tttggcacac ttcatggtta tgttgtcaga agtgacattt ttcctatatg

4621 ttgacagggt ggtgacttca cacgccataa tggcactggt ggcaagtcca tctatgggga

4681 gaaatttgaa gatgagaact tcatcctaaa gcatacgggt cctggcatct tgtccatggc

4741 aaatgctgga cccaacacaa atggttccca gtttttcatc tgcactgcca agactgagtg

4801 gtaagggtac aacatggcac actaaccacc tgactaaatg aaaagttgcc ctggggggaa

4861 cggaacaaac actacttttc ttcaaccttt gcttccacag actttttcat ccctaagata

4921 ctagaagaag agcatacata aatgacaaat atagccaatg tgatacagaa tgtcagatac

4981 tatgatagaa acttggccct tagctgggtg gttgaattag gtgctacttt tttgagatgg

5041 agttttgctc tgttgccagg ttggagtgca gtggcacaat ctgggctcac tgcaacctct

5101 gcctcctggg ttcaagcgat tctcctgcct tggcctcctg agtagctgag aatacagatg

5161 tgtgccagca tgcctggcta attttttgta tttttgtgga gacggggttt catcatgttg

5221 gccaagctgg tcttgaactc gtgacttaag gtgaaccacc tgccttggcc ccccaaagtg

5281 ctgggatttc aggcatgagc cactgcgccc aaccaattaa gtgctttttt tttttttttt

5341 cttttctcag actggatctc gctcttatct cccaggttgg agtgcagtgg tgccatctca

5401 gctcactgca acctcctccc gggttcaagc aattcttctg cctcagcctc tcaagtagct

5461 ggaactacag gcatgcacca ccactcccag ctaaattgtg tattattagt agagcgggat

5521 ttaccatgtt gtccaggctg gtctcgaact cctgggctca agtgatctgc ctgccttgac

5581 ccccccgaag tgctgggatt acaggcatga gccactgtgc ccacccaatt aagtgctgct EPI-109 903

5641 tttatgttac tattaataac atgcggttgg ttgggttttt tgtttctttg gggtttttgt

5701 tttgttttgt ttgtttttgg gggagggggg cgcaattcat tctatatgtg taactctttt

5761 ttgagatgga gtttcgctct gtcgcccagg ctggagtgca gtggcgcgat ctcggctcac

5821 tgcaagctcc gcctcccagg ttcacgccat tctcctgcct cagcctcccg agtagctggg

5881 actataggca catgccacca tgcccggcta attttttgta tttttagtag agacagggtt

5941 tcaccgtgtt agccaggatg gtctcgatct cctgacctcg tgatccgccc gccttggcct

6001 cccaaagtgc tgggattaca ggcgtgagcc accgcacccg gcctatatgt gtaactcttt

6061 aatggtaatt ggagaatcat gtttaatgac atttagtaca aaaggcttca gttaaaaaaa

6121 aaaaaaaaaa gctacctttc tcgtcttggt tcatgacaca tggaggctgc ttgtttgtgg

6181 ttgccagtca taatgattgt tcttcctttt caaggttgga tggcaagcat gtggtgtttg

6241 gcaaagtgaa agaaggcatg aatattgtgg aggccatgga gcgctttggg tccaggaatg

6301 gcaagaccag caagaagatc accattgctg actgtggaca actcgaataa gtttgacttg

6361 tgttttatct taaccaccag atcattcctt ctgtagctca ggagagcacc cctccacccc

6421 atttgctcgc agtatcctag aatctttgtg ctctcgctgc agttcccttt gggttccatg

6481 ttttccttgt tccctcccat gcctagctgg attgcagagt taagtttatg attatgaaat

6541 aaaaactaaa taacaattgt cctcgtttga gttaagtgtt gatgtaggct ttattttaag

6601 cagtaatggg ttacttctga aacatcactt gtttgcttaa ttctacacag tacttagatt

6661 ttttttactt tccagtccca ggaagtgtca atgtttgttg agtggaatat t

1 gtgtactatt agccatggtc aaccccaccg tgttcttcga cattgccgtc gacggcgagc

61 ccttgggccg cgtctccttt gagctgtttg cagacaaggt cccaaagaca gcagaaaatt

121 ttcgtgctct gagcactgga gagaaaggat ttggttataa gggttcctgc tttcacagaa

181 ttattccagg gtttatgtgt cagggtggtg acttcacacg ccataatggc actggtggca

241 agtccatcta tggggagaaa tttgaagatg agaacttcat cctaaagcat acgggtcctg

301 gcatcttgtc catggcaaat gctggaccca acacaaatgg ttcccagttt ttcatctgca

361 ctgccaagac tgagtggttg gatggcaagc atgtggtgtt tggcaaagtg aaagaaggca

421 tgaatattgt ggaggccatg gagcgctttg ggtccaggaa tggcaagacc agcaagaaga

481 tcaccattgc tgactgtgga caactcgaat aagtttgact tgtgttttat cttaaccacc

541 agatcattcc ttctgtagct caggagagca cccctccacc ccatttgctc gcagtatcct

601 agaatctttg tgctctcgct gcagttccct ttgggttcca tgttttcctt gttccctccc

661 atgcctagct ggattgcaga gttaagttta tgattatgaa ataaaaacta aataacaatt

721 gtc

(2) INFORMATION FOR SEQ ID NO:2692: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2692

1 gatctgtcta gggctgtcag tggagtattg aagtccccca cgattattgt gttactgtct

61 atctcatttc ttaggtctat taataacagg tttttttgtt ttgttttgtt ttgttttgtt

121 tttttgagat ggagttttgc tcttgttgcc caggctggag tgcaatggca tgatctcagc

181 tcactgcaac ctccgcctcc tgggttcaag cgattctcct gcctcagcct cccgagcagc

241 tgggactaca ggcatgcacc accacacctg gctaattttg tatttttagt agagacaagg

301 gttctccatg ttggtcaggc tggtcttgaa ctcccgacct ctggtgatct tcccacctca

361 gcctcccaaa gcgctgggat tacaggcatg agccaccgtg cccggcccat agtaactgtt

421 ttataaattt gggagctcca gtgtttagta catatatgtt tagaattgtg atatttccct

481 gttggacaag gccttttacc attatataat gccctctttt gtctctttta gctgctgttg

541 ctttaaaatt tgttttgtct gatataagaa tagctacctc tgctcacttt tggtgtctat

601 gtgcatgaaa tgcctttctc caccccttta ctttatgtga gtccttatgt gttgttaggc

661 cagcatcacc ctaatatcaa aaccagcaaa ggacatacca aaaaagaaca ttacagacca

721 atatttttga tgaacacaga tgctaaaatc ctcaacaaaa tactagctaa ccagttgcaa

781 caacatacca aaaagataat ccaccatgat caagtaagtt tcgtaccagg gatgcagaaa

841 agcagcagat ggtttgtgag ttcttatcta ttctgcaatt ctgtagaaaa gtggagcatt

901 taggccattt acattcaatg ttagtattga aatttgaggt accattgcat tcatcatgct

961 ctttgttgcc tgcgtacttt ggtttgtttt ttgattttgc tctttaactt gtatttttgt

1021 tttataggtc ctgtgtgatt tatgctttaa agagattctg ttttgatgtg tttccaggat

1081 ttctttcaag atttagagct cctttaaaca gttcttgtag cagtgccttg gtaatggcaa

1141 attctctcag tatttgtttg tctgaaaacg actgtatctt tccttcatat gtgatgctta

1201 gtttcactgg atgcaaaatt cttgactgat aattgttttg tttgaggagg ctgaagatag

1261 ggccccaacc ccttctagct tgtagggtct ctgctgagaa atctgctatt aatctgatag

1321 gttttcctta taggttacct ggtgcttctg tctcacagct cttaagattc tttccttggt

1381 cttaactttg tataacctga cgacaatgtg cctaggtgaa tatctttttg tatccatcgc

1441 ccaggctgga gtgcagtggc gcaattttgg ctcactgcaa cctctgcctc ccaggttcaa

1501 gcaattctcc tgcctcagcc tcccaaggag ctgggattac aggctcctgc caccacaccc

1561 agctaatttt ttttttttgt atttttagta gagacagggt tttgccatgt tggccagcct

1621 ggtctcaaac tcctgacctc aggtgatcca cctgcctcgg cctcccaaag tgctaggatt

1681 acaggcgtga gcccccgcac ccgagccctg atattaattt ttaaattaaa agactttatt

1741 tttaaaagca gtttgaggtt tacagaaaaa ctgagcagaa agtacagtct ctatataccc

1801 cctactccct gcccccagtt ttccctgtta ttaacatttg tgttaatgtg gcatatttgt

1861 tacaatcagt gaatcaatat tgataaatta aagtccatat gttagtgttc actctgtgtg

1921 ttatacagtt ctatgggttt tgccaaatgt attaatatgt catgtatcca tcattacagt EPI-109 904

1981 atcatccagc ataatttcac tgtcctgaaa atgccctgtg ctccacttat tcatcttttc 2041 cccacttgct atcaccacac caaagccctc acaaccactt atctttttaa tatatccata 2101 gttttgcctt ttgcagaaca tcatatcatt agaatcacaa taatatgtgg cttttcagac 2161 tggtttcttt cactcagcaa catgcagtta agggtcttcc gggtcttttg tggcttgaca 2221 gctcatttct ttttatcact gaataatatt gcattgtata gatataccac agtttttttt 2281 aaatttactc atcattaaag gacatcttga ttacttctaa tttctggcaa taatgaataa 2341 agttgataca aaaacttttg tgtaggattt tgtgtggaca tatgttttca actcattgag 2401 gtaaatgcct aaggcatatt tagttttgta agaaactgct aaactatctt ccaaagtatc 2461 tgtaccattt tgcattccca ccagctatga aagagtttct gttctacatc ttcacaaaca 2521 ttggtgttat cagtgttttg gattttagcc attctaattg gtgtggagtg gtatctcatt 2581 gttgttttaa ttttgcaatt ccctaatgac atatatgttg agcatctttt catatgcata 2641 tttaccatct gtatatcttc tttgggcata tgtccattca gatcttttgc acatcttttc 2701 attgggttgc tcattttctt attgagtttt aagagttctt catatatttt tgataacagt 2761 cctttatcag atatgtcttc tgcaaatatt ttctcccagt ctttgtcgtg tcttttcatt 2821 tacttaacag tgtctttcat aaaacagaag gttttaactt tgatgaagtc taacttgcca 2881 attttttctt tcatggattg tgctttgtgt gttgtatcta aaaactcatt gccaaacaca 2941 aggtcacctc tatgttctcc tatgttatct tctagaagct ttgtagtttt ctgttttaca 3001 tttatagggg ctgtgagaag gtgacagagg ttacatgagg taataaggat agggccttag 3061 ttgaataagg ctagtgccct tataagagga agagacgcca gttttctctc tctctaccat 3121 acgaagacac agcaagaaag tggccatcta caagtcaaga agtgggccat caccagaaac 3181 caaattactg gcaccttgat cttaaacttc ccagcttcca aaactgtgag aaataaattt 3241 ctgctgttta agccatgcaa cctacagtat aagttatagc agcccaagca gactaagaca 3301 gaacccttag catattaatc atagttactt taaatctctg gtcccataat tccaaaatat 3361 ctgccacatc tgagtctggt tctagtgctt gctttgtttc ttcaagactg tggttttttt 3421 tctcttttta gcatatctta taatttttct gttcaaagca aggcatgatg tactgggtaa 3481 agggaactga actgaggtag ataggtgttt agaatgaaat ttagaggcaa cttaagaaag 3541 tactcaaaaa acaaaattat gggagcatgc taaatggaca caggagccag cctgaaagag 3601 cttgcaatgg acaaagttgg aacaatttga gcaacaaaat aagttattct tccttataga 3661 ggaattctaa ataatttata tagatacttg ccttccagga agtggcactt aatccccatc 3721 aaaccctcat aagtgtgggc tggacttggt aacttccttc caaaaaatag agtatggaaa 3781 aggggtgaag taacttcata gtggaaaaac ctggcaaaca ctaccttggt tagctgagca 3841 aagccttgat atggtgtgat gagaatggaa tattaccttt gtgatctttc tctcaaacac 3901 ttataatccc attctaatca tgaggaaagc gtaagacaaa tcccaattga gggacattct

3961 acaaaatacc tgaggagtac tcctcaatag gtcatcaaaa caagtcttag aaactgtcac 4021 agtcaagaag aaactaagga aaaatgacaa ctaaatgcaa tgtggtatca tggactggct 4081 cctagaacag aaaaagtcag tatataaaaa ctaagaaaat ctgaataaag tatggacttt 4141 agtgataata atgtatcaat attggtttat tacttgtagc aaatgtacca tactaatcta 4201 agatgataat aaaaacaata actctgtgta gggccaaagg gagggaagtg ggctgatacg 4261 ggaactctcc gcactatctt agcaactttt tggcaaatct aaaattactc caagatacta 4321 agcttctttt ttaaaaaaaa tcacaaaacc tgaaaaattt taaagaaata aaaatttaaa 4381 aattaaaaag agtcaaatcc cagctgtatt tttattaatt atgtaatatt gtacaagtca 4441 ctctctgagc tttggtgtcc ctgtttataa aagtgataga atacattttt gagtgacatc 4501 tgaaagatag cagagtagga agctccaggc cctcctttcc ccatgtaatc tgtgaaagga 4561 aattcaattt cgggacgcca aactcattta gcgaaaggga aaagtcaaag tgggaactgg

4621 gtcatgcaaa cctgcctccc acttttgggt cctcaataag atggctacaa gatgaaaagc 4681 tacatgcctc cgccatattt tgcccacaag gaaattccta gtgagttgtt aaaatttcac 4741 cgtagcaatg caaattgata gcttatcttt acaggtgcag tcgcccccgg cgcactagac 4801 ataaatgcac atctgagtgt tcccctgccc cattttgtcc atgttatctt atgtaaaatg 4861 catattcccc acatttttcc tctgcctctt ttatgtcatc ttattaatgc agattccctg 4921 agccagacaa aggcatgaat gactattttt ccctaccctc ctcttacatg aaaattgtgt 4981 acttctcagt atcgcaccct ttccccttta aattttgagc cctcaaaatc atcttcggag 5041 acaggcatag acctgtctcc tgagtgcatc cttaactttg gcaaataaat cccctaaaat 5101 gattgagact tgtcattttt ctcaattgac atctggtaac cacgaaggga tcctgagtga 5161 aagtgaccca gcctgcagta gctcacctct cagtgcttgg caccggcttg gtcaccttat 5221 agcccaaact gagaggacaa tttgccaaag tcgaggacct ctttccaggg atctctgatc 5281 ttccaacatt ttccagttgg gggtctgaag tttatttgct gttaaaaaca aaacaaaaca 5341 acaaaaacaa caaaaattcc tttttttgta ggcgtttcca ctcacttcca tcaaggaagg 5401 cgagcctgtc tgcttctgca tatgcagaga gcaatcttca gcttgggccc ccatcactag 5461 gtaagaaact ggtttggaat tctgtcttgc aaattctttt aaacgactag aattagcact 5521 aacaaccagc tggtgttaat ttcctgctta cccttagagc gctcagaaat catataattt 5581 gcgtgatcat tgttagtttt gtttaattgt tttgtttctg ggtttgtgtg tgtgtgtgtg 5641 tgtgtgtata tatatctgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtatgtgtg 5701 tgtgtgtgtg ttttggtcct ttcccctatc ggatttgacc aattctgaac cttcaagctc 5761 atgagtgtga aattttccac tctgaagaaa cagaacacat tgctcccctc agccctttgg 5821 ggcattctca ggcgactgag aatcacatga gggtttctgg gagaaatgct ccctaagaca 5881 tgcagcagct ctaaataggt ttccccctca aaagaacata cttagggtct aatctcagcc 5941 agcagatgca tataaggaac tgacccctcc caaactttga gcccctgaca cactgtgcca 6001 ggtggccaca acgctggtgg accaaactgg ttcagggtgt aatggccctg tgaaaagcta 6061 ggtttgcaag cagcacattt tgggtccaac acacatccca acttggtcaa atccaaaggg 6121 gaactctaaa ttatagagaa caaggcctct aagaccccag cagttgcaga atataaagtt 6181 cccctcttag aaactccagc agggtatatg caaaatactt atggtgaatc atcatgcaaa 6241 tatttaacca agcggaccac tataactaaa gcagattcta agttacaatg gcctaaatgg 6301 ggatcttttg agatgcccaa attagtgtac ctgtgaacca ggatggagaa tgcagacaca 6361 aaaaccaaac aaccagaatg ggacagctat tttcagtggt agctgcaaag tagcaaaagt 6421 ggggaagacc actgtcacgc gtgtctgggt gaagtgacca ccaaacaggc tttgtgtgtg EPI-109 905

6481 caacaaggct gtttatttca cctgggtgca ggtgggctga gtccgaaaaa gatgtcagca

6541 aagggagtta ggggtggggc agttttatag gatttgagta ggtagtgtca ggaggcccga

6601 cactcctgtc ttcttatatt aataagaaaa acaaaacaag atagtggcga agtgttgggg

6661 tggcaaaaat tttggggggt ggtatagaga gataatgggc aatgtttctc agggctgctt

6721 cgagcaggat taggggcagc gtgggaacct agagtgggag agattaagct gaaggaagat

6781 tttgtggtaa ggggtgatat tgtggggttg ttagaagcaa tatttgttgt acagaatgat

6841 tggtgatggc ctggatacag ttttgtatga attgagaaac taaacagaag acacaaggtc

6901 cgaataagag aaggagaaaa acaggtatta aaggactaag aattgggagg acccaggaca

6961 tctaattaga gtgcctaagg gggttcagcg tgattattgc ttggttggtc agttttgggg

7021 ctctatcctt gagttttttt atgttgtcac ataccaggcc agattgattt aggtgaaaac

7081 aacactcttc atttaaaaat atagagtccc ctttttttaa gcagtgagta agcggaagtc

7141 tcggtgattt tggaggaaat agaaatgcaa agccagcaat tgtttgttaa agaaggatta

7201 gaaacggcta ggagagagtg agattgatag tgtggtggag atagctgggg agaggtagag

7261 ggtggcataa gaatgggaac gagaataaga gtgagtaaaa aagtaaagaa taggacttca

7321 tcagggtgaa agtaccggac tgtgccttgc cactgaagat cttttatcca cttcaagaga

7381 gatttaaggg tggtggtttg agataaaacc aggagatacc agttatgatg gtttggagga

7441 aaagtgtaaa ctgggagtgt aaacaagggc agggcattta tgagtagttg agaatggtga

7501 ataggagtat gactagacag aagatagtag ggatgacaag tttttggggt gcagtccaag

7561 ttgggctggt gtctggaatg agactggggc ctaataaaaa ggagtgtcca tacaggagct

7621 caaatgggct gtaccctgta gcatcccgag gacaggccca aattctgaga agggcaagtg

7681 gtaaaagtat tgtccagtcc tttttaagtt ggaggctgag cttggtgagg tgtgttttta

7741 aaagaccatt agtccatttt acctttcctg aagattgagg atgggaaggg gtatgaaggt

7801 tccactgaat accaggagcc tgagaaactg cttgggtgat ttgactaata aaggccggtc

7861 cgttatcaga ctgtatagag gtgggaaggc caaaccgagg aattgtgtct gacagaaggg

7921 aagaaatgac cacagtggac ttctcagacc ctgtgggaaa tgtctctacc catccagtga

7981 aagtgtctac ccagaccaag aggtatttta gtttcctgac tcagggcatg tgagtaaagt

8041 caatttgcca gtcctgggca ggggcaaatc cctgagcttg atgtgtaggg aagggagggg

8101 gcctgaacaa tccctgagaa gtagtagaat agcagatgga acactgagaa gtgatttcct

8161 tgaggataga gttccacgat agaaaggaaa tgagaggttc taagaggcgg gctagcagct

8221 tgtaacctac atggaagaag ttatgaaatg atgacagaat agaatgggcc tgtaaggctg

8281 gaagcaaata ttttccttgg tccaagaacc atttgccttg tgtgggaaga gattgatagg

8341 tggaagtttc agcgggggag taggtgggag tgaccaatga aaaggagaaa aactggcagt

8401 gagggacaga agttggaatg ctagctgctt ttttagttat cttattagca taagtgttgc

8461 cttgagcgat gggatctgat gccttttgat ggcccttgca gtgaatgact agcttttttg

8521 gaagtagagc agctttaaga agagttttta ttaaggaggc attaattatg gaggaccttt

8581 gtgtagtggg gaaacttttt tctgctcata taacagcatg gtagtgcagg atatggaagg

8641 catatttaaa gtcagtataa atattaacac atagtccctt tgcaagagtg agggcctgag

8701 ttaaggcaat gagtttggct tgctgagagg tagtggaggg gggcagagca gtagcctcaa

8761 ggatagatgt ggaagacact atagcttagc ctgcctttgc cagtgattgg cgattaggcc

8821 tggtggaact gccatcaagt gtgatcaggg tgaagaacag gaaagaagga aatatgggga

8881 aatggagtga atgccaggtg gatcagagag atacagtcat gggggtcaga tgtggtatca

8941 ggaataatgt gggaggccgg attgaagtcc aggccaggaa caacggtaac tgtgggagac

9001 tcaagaaaga gtaagtacag ctgaaggagc cagggggcag gaagtgtgag gaggaaaata

9061 gattttgaaa gttatgggaa ctgtagaggg ttagtggagc atagcttgtg atttttaggg

9121 cctctaaaag tattaaagcg gcagcaatga ggtgtggctg tagcctagga atagtcaggg

9181 aagcggataa tttagttaaa atgtctcaat ctaataaggg agctgggcag gtggggataa

9241 ctaaaaaaga gtgcataaaa gaatgttgtc caagttggca ccagagttgg ggagttttaa

9301 ggggtttaga agccttgctg tcaataccca caacagttat ggaggcaagg gaaacagtcc

9361 cttaaaaaga aggtaatgtg gagtgggtag cctccatatt gattaagaag gggacggact

9421 taccctccac tgtaagagtt acccaaagtg tctgtgatgg tccaggaggt ttccgaggcg

9481 attaggcaat gtcagtcttc aactgctaag ccacgaatat ctgggaagga gtcagtcaga

9541 gagccttggg ccagagttcc aggggatctg ggagtggctg ccaggcgagt tggacagtcc

9601 aatttccagt ggggtcccgc acagatggga catggcttag gaggaatccc gggctgcggg

9661 cattccttgg cccagtggc^'c agatttccgg cacttgaagc aagatcctgg gggtggcagt

9721 cctggaggaa cgcctggctg ctgcagttca ggtgttttga agttcttgtg tgctggagat

9781 gtggctgggg tttctctcac agtggaggca agtaattgca actcagaaat acgttgctac

9841 ttggctgcct ctactccatt attgtccaca ttgaaggaga ggttaattaa gtcctgttgt

9901 ggggtttgag ggccggaatc taatttttgg agctttttct aatgtcagga gcaggttggg

9961 taataaaatg catattgaga ataagatggc tttctggccc ttctgggtct agggcagtaa

10021 agcatctaag ggttgttgcc aaacgggaca tgaactaggc tggattttta tatttgatga

10081 aaaagagcct aaccactaac tgatttggga gaggtcagat aaagaaaaag gagaattaac

10141 cttggctatg ccttcagctc cagccacctc tttaagagga aattgttggg caggtcgggg

10201 agggctagtc acagaacaaa actataagct ggaccaggtg tgaggagggg aggtgataaa

10261 aggattatag ggtgggagag cagaggctga ggaagaattg ggacctggct cggcgtggca

10321. aggagcagcc tggggaggag gggagaggtc agataggtcc gtagaaaagg aggattcaaa

10381 ggactcagag cttgggatgg agactgaagg aacaggagag aaagaagaaa gatttgggac

10441 aagtcgcact gggagcagag actaaggagg gatcaatgtg taaaagaatg cctggacgtc

10501 aggcacctca gacccatttg cccatttttt gaccaaaatc atccaggtct tgtaaaatgg

10561 agaaatcaaa agtgccgttt tctggctatt tagaaccatt attgagtttg tattggggcc

10621 aagcagtgtt gcagaagaaa ataagacgct taggttttag gtcaggcgag agttgaagag

10681 gttttaagtt tttgagaaca caggctaagg gataagaaga gggaatggag ggtggaaggt

10741 tgcccatagt gaagaaggca agccccgaga aaatagaggg tagagacatg gagaaggggg

10801 gtggtgagca gccctgggct gcaatgtggg cgagcagcca cagccaaagc aggcgtccct

10861 gcaattgact tgccaccaag ggaatgtggg tgaatgacca aggtaggcat ccctgcggtg

10921 atcagacacc aatggagtgt gggtgaataa tcaggcaggt gtccccgcag tgattaaaca EPI-109 906

10981 ccaagggaag actgtcttcc tgagttcatg actggcgccg gagttctggg tccatggata 11041 aaatgtgtct cctttgtctc tactagagag gaaaaagaac tagaattgga aggacagaga 11101 gattgaaggg tagcgagaga gggagactga agggtggcaa gagaggctgg agaagagagt 11161 aaaaagacca cttacccgat ttgaaattgg tgagatgttc cttgggctgg ttggtctgag 11221 gacccgaggt cataggtgga tctcctcatg gagtgagggc gaggacaggg gactggtctc 11281 ccaaaggagt cctcctgtcc cgggtcttcg gcaccaaatg tcacactcgt ccgtgtgaag 11341 agaccaccaa acaggctttg tgtgagcaac aaggctgttt atttcacctg ggcgcagttg 11401 ggctgagtcc gaaaaaggag tcagcaaagg gagttagggg tggggcagtt ttataggatt 11461 taggtaggta gtggaaaatt acagtcaaag ggggttgttc tcttgcgggc aggggctggg 11521 gtcacaaggt gctcggtggg ggagcttctg agctaggaca tttcacaagg taatgtaatc 11581 agttaaggca ggaacaggcc attttcactt cttttgtgat tcttcagttg cttcaggcca 11641 tctggatata tacgtgcagg cttgggctca gaggcctgac aaccacctca tctccctaca 11701 ggaggccaac aaacaactta gaaatgctaa ccaagaactc tgtaatcttg tatctctctt 11761 aaagaaatcc tcagaattcc ttacttcccc cttggtacct ccccctacac ccctactcta 11821 ccctgaccaa tctgaacttc ctggaccaga tctgtccgcc gcctctactg catgtctaac 11881 acttgctcaa cagaaggcag ttcagagtct gactgcaaag accccacccc ctcatgattc 11941 cctgacagct ccaatggcaa catctcatct ggaagatgtg gaaaaggggg accgtgcagg 12001 gatatctctc atgatcaccc tattttggga acaactgcta acaggtaggg gaaccctggt 12061 aattgtctac caacaccctg gtcaaaggct gaattccaag gcataaagaa tttcctgacc 12121 cccataaaga tccaattggg tttgagtatt tgagctcatt gtcagaacct atgacccagg 12181 tcattcagac ttttatcagc tagtccacat gttggtctca gaagctaaag ctaaggaatg 12241 gctgggaaaa gcacaatggt cagactctat agcagatttg acccctgaag gcccaatgga 12301 gccacaacaa ccagccccca caaatccaga agacaggcac aaagatgtgc aggaatgagc 12361 aaccactcta ttaaatatca ttccttcagt gttccaaagg gttgtggatt ggaataaaat 12421 ccaacaatgt caccagaacc caaataaatt agttttagat tatttaacac attttgataa 12481 aactttaaaa caacattgtg ggatgtcagc tgattgcttt gaaaacaata aaaatgatac 12541 attattaaat gcaaatttct taaacggact agatgatgat ttagccaccc ttgtaaaaca 12601 caaattggac cacagccaga actaatgaac tagttaactt agctgaccaa ttatcccgca 12661 ctatgataaa acaaggaaaa acagaagatt gcccaagtta tgcatttaca gctaaagcaa 12721 ttaacttctc aagcctctcg gccccagaaa gattttaagc tccctcggtc tgaggactct 12781 tccctcccag tctgttacaa ctgtaaatga ccgagacacc ttatgatgga ttgccttagg 12841 ctgaaacaaa agaaaaggca gaatgcaact caggaagaca aggggtgctc caaggaaata 12901 caggggtttc acctctccaa atattctacc ctgacaaacc aattggggga gattaatata 12961 ataataaacc atgagtttac aactgcctta actgacatag gtgtgactat ctctgaaaaa 13021 tcccacctta tttagaaacc ccattcctca gagtaatgaa agaatgaaca tggtgggtat 13081 gtctaataaa atgatctcat gttttaagtc caaacccgta ccttagggtt catcaggttc 13141 cactaccctg tcgcaggctc taagtgtgac acactcagta ggtcccatat gtttctaata 13201 tgcactgggg cccctgtcaa acttttgggc tgtgatctca acatccataa tgcccatatc 13261 tctttttcat caaaaggtga aactttttta gaattggagc caggagacca aaaataccat 13321 atttaaaaat gtcctgacaa cgtacaattt agtactagta atgttaaaat gtcatcttgt 13381 gaccaggaaa ataaaataga gacagagaag gaaatattag ggaagaagag agaacattgg 13441 aatacagagc aggaaacagt aaaactcctt ttagtttccc cagtcttcct gttaacacca 13501 gaagcagagc acttgctcaa ggatgtgtcc tcccacttat agtctcagtc aaatacagat 13561 acagagaaag tattctcagc cattccaata aaggtagaga taaatccaaa gaaaccccta 13621 tccaacctta aacactatcc tctgcaaaag gaagccatag atggaattgc tcctgtcata 13681 caagattatc tgagaaacgg gctcattatt ccctgcacaa tcccctgaaa cagccctata 13741 ttccctgtaa agaaactaag cgggagagga tggaaatttg tgcaggaatt gagggcaata 13801 aacaatatca taattctcag gcacacagta gtccccaacc cacaaaccct tctatcacct 13861 atatccacta ccagccagta tttctcagtt gtggatctct gcagtgcctt ctttagtatt 13921 cctgtagaac cagacagcca atatttgttt gtctttattt ggaaagaatg gcaatatacg 13981 tggactataa tgccccaaag gtatacagaa agtcccactt agtgttccca aatattagaa 14041 gctgatttgg agaattaaat attttcccag ggctcaacat tcatctactc tcctttgttc 14101 agacacactc tcttcctctc aggaagatag tctatattta ctcaaacagc caccaaggga 14161 cacaaatgtc taaagacaaa cttcagctat gcttacctga agttaagtat ttgggacata 14221 ttatctcagc caaaggactg agtattaacc ctgatagagt gaggaatttt agctttccca 14281 atgcccgtca ctaagaaaca acttagagta ttttggggcc tggcaggcta ttgtagaaac 14341 tggataccaa atttctccct tatggctcaa cttcagtgta catacctaaa aaatgaacaa 14401 cctgatccca tcatgtggac tccggaggga caatcagctg tacaacaaat aaaggaaatt 14461 ctgactaatg ccccagcctt agggcacccg aactacaaat tgcctttctc ccttttcata 14521 cacgaagttg gaggtactgc atccggagta ctgacccaga aacatggtga tcatcagaga 14581 cctataggct attatagcca acagctggac cctgtggctc aagggctgcc tccctatgtg 14641 agagcaatag cagccacggc ccttccgtat aagtctgttg aagaaataat tataggttcc 14701 ccccttaaca tttttgtgcc acattctctt gagacccttc taaactctca tcatacacaa 14761 cacctgtctg tcaactggtt agcctcttat gaaattttgc ttttatcatc tcccaatatt 14821 actagttcct gctgtaataa tcttaatctg gccactctct tgccaggccc ttctgacaaa 14881 accccctcat gactgtgttt tgatgactga cttctcaccc ccaggacaga cctacaagag 14941 atgccactgg ataatgctga gatagaatgg tatacagatg gatcttattt aagaggagag 15001 gatggaaatt ttatagcagg atatgctgtg gtttccttac tagaggtaat tgaagccaat 15061 cctctccccc aagccagatc agctcaagtg accaaattgg ttgccctgac cgaagcttgt 15121 caattggcaa aagacaaggc tgcaaacatt tacactgaca gccactatgc ttttggggtt 15181 gctcatgact gggatgttat ggaaagagag aggatattta accccctcag ggcaacccat 15241 aaaaaatgga caagtatcag agttgttaga agctgttcta acaccaaaac gcttggcaat 15301 tataaaaatc ccaggttggc caggcgcagt ggctcacgcc tgtaatccca gcactttggg 15361 aggccgaggc aggaggatca cgaggtcagg agatcgagac catcctggct aacatggcga 15421 aaccccgtct ctactaaaaa tacaaacccc gtctctacta aaaatacaaa aagttagccg EPI-109 907

15481 ggcgtggtgg tgggcgcttg tagtcccagc tactcgggag gctgaggcag gagaatggca

15541 tgaacctggg aggcagagct tgcagtgagc cgagatggcg ccactgcact ccagcctggg

15601 caacagagag agactccgtc tcaaaaataa ataaataaaa ttaaaaaaaa atcccaggtc

15661 actcaaaatt agacaccaca gtaagtcagg gtaaccaatt tgctgaagcc acagctaaaa

15721 gagcagcatt caagccatca gccccaagtt ggaaaatggc cataaaaccc aaaacactta

15781 aatacatgtt gaaagaaacc cagagcatag ctcctacaaa agagaaatct acttggaaac

15841 aggcaggggg atacttgtct cccaaaactg aaatatggtg tggacctaat tattccattc

15901 caagaaaccc attattccaa tggaatgtca ggtgtccctt atgaaatatg ttcataatct

15961 aacccattgg aatccagata aaataatatc ctggtgtaaa caatattact ggaaaccatc

16021 cttcacagtg gcacaaaaag tttactctca gccgggcacc atggctcaca cctgtaatcc

16081 cagcactttg ggaggcccag gcaggtagat cacctgaggt caggagttca agaccagcct

16141 ggctaacatg gcaaaaccct gtatctacta aaaatacaaa aattagccag gcatggtggt

16201 gcgtgcctgt aatcctgctt cttgggaggc tgaggcagaa gaatcgcctg aacccaggag

16261 gcagaggttg cagtgagctg agatcacgcc attgcactct agcctgggcg acaagagcga

16321 aactccatct caaaaaacca aacaaaaaag tttactctca atgtgttatc tgtcccaaac

16381 ataacccagg aaaacccctc catggggccc agggtcattt tccccttccg gctgaccttt

16441 tgaggtatga cagcttgatt ttatccagct gccatcatct caatgttaca agtatgtttt

16501 agtaatggtc tgcatgtttt atcattgggt tgaagctttt ccctgcaggc aagcaacagc

16561 cacgacagtt ggaaaaatcc tactagaaaa aattgtccca ctgtggggag tcccctgtga

16621 acttcacagt gatgggggat catactttac tggccaggtt actcaaaata tttgtaaaat

16681 ttggcccata tttcaacatt tccattgtgc caccatcccc agtcttcagg cctggtggag

16741 aggaccaatg gaataattaa aacacaattg gctaagttca cagaggcatt tcacctcccc

16801 tggcccaaag cactacccct agtgctgctt atactacgat ccactccttt tggaaaacat

16861 caactgtctc cttatgaaat tataacagga aggcccatgt gtatgggaac gaacataacc

16921 aatccaactt ttctccaggg agatatattg caatattgtg agggactcat ttatcatctt

16981 agaaaaaacc aaaatttgtt aaaaaattcc tttcacggtg cgctccccga agataaggtg

17041 cctggtcatc tgcaacctgg agatttcatc tattggaaaa gacatctaat aaaggattcc

17101 cttcaaccct gatggaaggg cccgtaccag gcactactga ctaatccatg tactgcaaaa

17161 ttaaagagta tagattcatg gattcacatc tctcatctta aaaaggcaca acctcctgag

17221 tggactgtaa ctcccaccaa agaccttcac ctccggttca ctaaacatca acctgcaacc

17281 caggattaga agcagacaac agctgttgtg gactgcttaa acccaagaca cagaaccagg

17341 cctgtataca aagggaacgc ctctgtttat tgtacagtaa ccattacaat tattgtccta

17401 gatataccgg caactgctgt cttataaatg acagggcact tgccttgtct gatttaacac

17461 catttagtaa ctaaaatgaa tttcgcaacc ttgctattat taatcctata tccctacact

17521 ttcttgccac tgccacccac tgatgcccat gaaacaaacc tgtttctaca atgggctcag

17581 cattatgcag acaaattaca aagaacacct gctggatatg cagactcatg cctctttcca

17641 gtggctccag cctgccatgg tggatatccc ccttccaagg tcaggactgg atagaatacc

17701 aaaaatttat cacatcacag aaatggtctg gtattcttag tgctgggata acaaaagaca

17761 atacatacaa ttggcccatt aaaaacactc ttaagaacaa gggacatggg aaaagatttt

17821 gaatggaaag gaccaggtca ttagctctca ctttagcatc cccccagcta aaacagaagg

17881 tggtaaccac accccaaaca acagctcatt ttcaaaatgg aataatgcaa atttgggctg

17941 gatttatctg gctcacccgt tcgtctggcc aactcagcca aaattctcct ctgtgctggg

18001 agaaagaaac catatcaagg acctatggcc aaacagtacg agagatacgg ggtggacacc

18061 tggagaatgc tgtgaccaca ttatcatatt acaagacgct gactggaatg ccaccgattg

18121 ggtgcagcaa tcaggtattt attggatagc tccaaatggg acatattggc tatgtggcac

18181 taacttatgg ccgtggttac ctctagggta gttaggatga tgttccctag gttatgcttg

18241 ggcacaagac acgtaatcca gaccctgcca aaaccagcaa acctttttca tttacaattt

18301 cattggacat gttaggtatt ccaatggtat gatcacttag ctttaatctt tgtaccacag

18361 acaggtattg aagatgttat atggcatata gaggccttac ccaattacat ccaaaaggcc

18421 ctgaatgata gccacatgag tattgccttg ctaagcaatg aggtcatgct tatgaggaaa

18481 gttgtgctat acaaccatat ggctttagat atactcattg cagcacaagg ggggacctgt

18541 gccgtcataa aaactgaatg ttgtgtgtat attcagatga attgaagaac ataactcgat

18601 ttatgactga tatgaaaacc cagataacca acctgtcaga tctaaaaccc tcactaatca

18661 attggttgag tagttggttt ggatcctggg gaacttggtg gcagaagcta ctgcttataa

18721 taggaataat aataatttgt gttctgtcct gtttctgcta caatgttgtt acggtatgtg

18781 cttgcaaata agttaatgca caactgaaag ggctggggta ataattgccc agagaattgc

18841 tttaattgag gaagcagtaa tatagcttga cccagcttca aggtttgctt tccttttgtt

18901 gctataaata tgacctaggt ccctatatat atattttttt ctttttcttt tttcctttcc

18961 tttttccttt tttcctctcc cttttttttt taaatattcg tgggacacaa tttcctagga

19021 atgagccttc ctagcgacaa tgggcgtgac ttcctaggaa tgagccttcc tggtgatgtg

19081 ggacctaaac ttctagaaat aaactatcct agcaacagga aaccagttca gaaaagggag

19141 gaaaaatcaa cctgtagcca agaacccata ttccttttaa aatgcttcct tcaaaagatt

19201 ttaaataaaa aaagagggga aacctgaaag gaaattaaat tttgggaccc cccaaactca

19261 tttagcaaaa ggcaaaagtc aaaatgggaa ctgggtcatc caaacctgcc tccccctttt

19321. ggttcctcaa taaaattgtt acaagatgaa aagctacatg tctcctccat attttgccca

19381 cagagaaatt tctagtgagt tgttaaaatt tcaccatggc aatgcaaatc gatagcttat

19441 ctttacaggt gcagtcgccc ctggcccacc agacataaat gcatatctga gtgttcccct

19501 gcccaatttt gtctatgtta tcttatgtaa aatgcagatt ccccagattt ttcctctgcc

19561 ccttttatgt catcttttat ttatttattt atttatttat ttatttactt atttattttg

19621 agatggagtt tcgctcttgt tgcccaggct ggagtgcaat ggcacgatct cggctcacag

19681 caacctccgc ctcctgggtt caagcaattc tcctgcctca gcctccagag tagctgggat

19741 tacaggcatg caccaccaat cccagctaat ttttgtattt ttagtagaga tggggtttct

19801 ccatgttggt caggctggtc tcgaactcca gacctcaggt gatccacccg cctcggcctc

19861 ccaaagtgct gggattacag gcgtgagcca ccacgcctgg cctttttgtt gttatttagt

19921 tttatttcat atcataaact taactctgca atccagctag acatggaaag gaacaaggaa O 00/09525

EPI-109 908

19981 aacatggaac ccaaagggaa ctgcaatgag agcacaaaga ttataggcta ttgccagcaa 20041 atggggtgga ggggtgctct cctgagctac agaaggaatg gtctggtggt taagataaaa 20101 cacaagtcaa actttaataa gttgtccata gtcagcaatg gtgatcttct tgctggtctt 20161 gccattcctg gacccaaagc attccatggc ccccacaata tttatgcctt cttttacctt 20221 gccaaagacc acatgtttgt catccactca gtcttggcag tgcagatgaa aaactgggaa 20281 ctgtttgtgt ccagcatttg ccatggacaa gatgccagga cctgtatgct ttaggatgaa 20341 gttcttgtca tcaaatttct ccctgtagat ggacttgcca ccagtgccat tatggcaatg 20401 tgaagtcacc accctgacac ataaaccctg gaataagtct gtgaacgcag gaacccttat 20461 aaccaaatcc tttctctcca gtgtgcacag catgaaattt ttctggtgtc ttggaaactt 20521 gtctgcaaac agcttgaagg agatgtggcc caagagccca ccatctatgg tgatgttgaa 20581 gaacaaggtg gggttgacca tggctgatag tacggggctc ctggcagcag cagcatctgt 20641 gaagtggcca ttctatgtta tcttatattt aaaaaatgca gatttgctga accagacaaa 20701 ggcatgaatg actatttttc cctaccccct cttacatgaa aattgtttac ttctcaatat 20761 cctacccttt cccctttaaa tttgaagccc tcaaaatcac cttcggagaa aggcatagac 20821 ctgtctcctg ggcacgtcct taactttggc aaataaatct aaaatcattg ggacttattt 20881 catcattttt ctcaattgac aaaacattta aaaaataata cagactggac ccagcctgcc 20941 caactcccag tggagagcaa ggtttccttc tattttcata ggcaaccaga acaatgttct 21001 atgcacattt tgtcctcagt aagagggcct ctggccaaaa tttggctagc ggcccattgg 21061 gataagaagc taaccaaagc ccctgtgtta cagtgtaatt tagagagcag catggagagt 21121 atcatctcac caaaggtgaa gatagcatta cggacatcag gacatctctt actgggagta 21181 gtttgaatct atcacaggaa agccaaatat cttcttgcag actgtaatga agcattcatt 21241 aagataaaga tggctttttg atcaggtgtt gacctgcctg aggaaaatca ggaagcagct 21301 tataacacca ttactttact tgaataattt catgactttg atcagccact gcctgactta 21361 gatgacatcg atgtggccca gaagttcagc ctgggtcaga gtagagtgga agaaataacc 21421 gtgagagaag aagttgggaa tatcagtatt ttacaagaaa atggttttgg cgattttgga 21481 atggatgatc attgagatca gagaaagcag tgcttttgag gatgatgaca tgttagtagg 21541 cactactgct tctaatctcc tattagagtc tgaacagagc accagcaatc tgaatgagaa 21601 aattaaccat ttagaatatg aagaccaata taaagataat aattttggag aaggaaatga 21661 tggtggaata ttagaagaca aacttattag taataatgat ggtagtatct ttgatgatcc 21721 ccctgccctc tctgaggcag aggtaatgtt gccagagcag cctgcacatg atgatatacg 21781 ggtgaggatg ataatacatc aatgggtggg cctgatagtc ctgattcagt gaatcctgtt 21841 gaaccagcca actatgactg atcaaacaac acttgttcca aatgaggaag aagcatttgc 21901 attggaacct attgatataa ctgttaaaga aacaaacgcc aagaggaaga ggaagctaat 21961 tgttgacagt gtcaaaaact tggatagcaa gacaattaga gcccagctta atgattattc 22021 tgatattgtt actactttgg atctggcacc acccaccaag aaataggtga tgtggaaaga 22081 gacaggagta gtagaaaaac tgttttcttt acctgctcag cctttgtgga ataacagact 22141 actgacgctc tttacatgct gtcttacacc acttgtacca gaagacctta gaaaaagggg 22201 gaaaggaggg acagataatt tggatgagtt cctcaaagaa cttgaaaatc cagaggttcc 22261 tagagagaac tagcaacagc tacaccagca gcatgatgtt attgataagc ccattttgga 22321 agagccaagc catctccaga agtcagtgat gaggccagca gaacaaatct ggatgagtca 22381 gctatgcctc caccaccacc tcagggagtt aagtgaaaag ctggacaaat taacccagag 22441 cctgtgatgc ctcctcagca ggttgagcag atggaaatac tgcctgtaga gcttccccaa 22501 gaagaacctc caaatatctg tcagctaata ccagagttag aacttctgcc agaaaaagag 22561 aatgagaaag aaaaggggaa aaaaagatga tgaaggggaa aaggatgaag atgtttcagg 22621 gggtgatcaa gatcaggaag aaagaagatg gaagaaaagg actcagcaga tgcttcacgg 22681 tcttcagtga gctcttgcta aaactggagc tgaatctatc agtttgcttg agttatatca 22741 aaacacaaac agaaaacaaa ctgttgcaaa gttctacagc ttcttggttc ttaaaaagca 22801 gcaagctatt gagctgacac aggaagaact gtacagtaac atcatcgcaa cacccgggcc 22861 aaagttccat attttatgag gagctagaag cattatagct agtgttcatt tcactagtgc 22921 ttacaaattg cccccatgtg taggagacac agaacccttt gagaaaactt agatttttgt 22981 ctgtacaaag tctttgcctt tttctttctc attttttccc agtatattaa atttgtcagt 23041 ttcatctttg agggaaactg attagatgga tgtgtttgtg ttctgatgga gaaaacagca 23101 ccctaaggac tcagaagatt aacagttcag aacagatgtg tgcaatattg gtgcatgcaa 23161 tgatgttgag tggcagttga aagtcatgat ttttatctta gttcttcatt actgcattga 23221 aaaggaaaac ctgtctggga aaatgcctga cagtttaatt taaaactatg gtatgagtct 23281 ttgaaaagaa aaaaaaaaag cctttccatc agtagtaaca ctggcaatct tcttgttaac 23341 cactctcctt agggatggta cctgaaataa caaaggtcac cctcttgaga ttcgttttaa 23401 gtgtaattcc ctaatgagca aacgtgtacg tgaaattgtg ttgtgactga tacccttcag 23461 ctacagatag gactgacttg gtttaaagtg ttctattttg taaatcattc catttgagtc 23521 tttctgatga acttcgctat ctcgaaatct gtcattttag tgaggctcca aaatgagcag 23581 aaataggcct gattagagta gagtgactat caaatagcag actttctagg acctataaat 23641 agaagtttta aaaagatgtt tggatatatt tgactattca gatcatgaaa acagaaatta 23701 ccctgcctac tacaaggaca gactgatggg aaattataca ccaggtcaac ttaaccttta 23761 agcagacaat gctgtaaaaa ctaatggctt ctctgatatt tattgtaagt tttagtactg 23821 atctcctttt ccagtgctgc acactcctgt gtttggaact ttaatagctt tgcaacgaaa 23881 tcctatatcc ggtttcctat aatttaactg aagaaaaaca catccaaata aaggtctata 23941 ttaacagacc agatagcatc agaaatcatg tgactattat gattatcaga atatgtctta 24001 actttttagg gcaaaattaa cactgaaagt tctagcttaa gtgttgacac tttcgtgggg 24061 aaaaaaatca cttttgaaac agacttcagt gtatactcaa taatttaaaa ttatgtgaaa 24121 tgttttaaat ttgtgaactc attactgttt taatgattcc gtttcttgag agtttaacca 24181 taaaaaattg ctattgcaga tttattttca atatgctgtg cctgtaaacc atggagtttt 24241 ccctgtttgt aaaaagacat tgtagataat tgaatgtttg attttagaaa ggtcattggt 24301 ttcttgttac acattttgtt agtctgtttt ttttgcttat tgggtttaat attgttcttg 24361 aaaatagttg atgctatgtt atgtataact cttctaataa aagttgtgtt ataagttgaa 24421 acaaattata gtattacaga ctggctacaa taactttata ggaagtctga aaaatactca EPI-109 909

24481 aagttctata gcaaccaagc aaacacctag tcaagaaaac gatacagtca aaatggttag 24541 aaattttgtg acatttttac ttgcctgtac cccatccttc cctcctggca cacctgggga 24601 agcagcagcc ctgctcccaa ttccctccct ggaaccccag agagaggaaa gtggacttta 24661 tttgcaacat tctaacctgt caaggggctg cctgaggtac tggtctctgt tttacctaat 24721 tcggaggtca gacagggaaa agcaacatgg ctggatactc aggctcagga aaagccacag 24781 gaaatgatgg gcactactca tgaacactgc agggggccta caaactcaca gatacctgga 24841 gcaagagatc agaagtagaa gaatacaata gaacatctaa gcccaccttc tgagaagcag 24901 aggtgagact ctttaggaaa ttgagacatt ttaagcagtc atgcattcaa gggaactgga 24961 aaacaacaac aacaacaaca acaacagata cccaggccaa ggcaaaatgc atagccaaaa 25021 gaggtctaag aagaccttaa gacctcacat ggggctgatc ccaaagctga cagcatgccc 25081 tgctaattag tgaaggtctt ccctggcaca gaacctactt gtaatgacta gcagaggtgg 25141 ctgttttttt gaatgatcaa ttttaaaaat gaacaaaaaa ataacaaacc atgcaaagaa 25201 acaggaaaat atggcccatt caaaggaaga taataaactg tcagaaactg tccctgaaga 25261 aacacaagca tcagaagtac tagacaaaga caaaatgtct taaatatgct caaagagcta 25321 aatgaaaact caaagaacta aaggaaatga gaaaaatgac acataaacaa aagagaatat 25381 taacaaagag aaactataaa aaggaaccaa acagaaattc tggagctgaa aatacagtat 25441 ctgaattgaa aaacgcctag agggattcaa cagtagattc aaacaggaag aaaaaagaat 25501 cagtgaactt gaagataagt cctttgaaat tattgaatct gaagaccaaa taataataat 25561 aataattaag aaaagtggac agagactaag agacctatgg gataccatca agctaaccaa 25621 tatatgcatt acagaaatct cagatggtga cgggataaag aaaggagcag aggaactatt 25681 tgaaaaaata atggctgaaa acttcccaaa tttgaggaaa ggcattgatt cacaaatcca 25741 aaaatcttgc tgatctccag gtaggataaa cccaaagcag tacataccaa gacacattat 25801 attctaacaa aagccaaaga catggaacac tgcaggggga ctacagactc acagaaaccg 25861 ggggcaagag atcagaggta aaggaataca atacaaagtc taaggccccc tcaagaatct 25921 tgaaagaagc aagagaaaag taactcatca tgcacaatgg atcttcaata acattatcag 25981 tggatttctc agcaaaaacc ttgaaggaca caaggaattg aataccatat ttaaaggaaa 26041 ttttttaatt gttatttttc cataagttat tggagttcag gtggtatttg gttacgagta 26101 agttatttaa tggtgatttg tgagattttg gtgacctgtc accgaagcag tatacactgc 26161 actgtatttg tagtctttca tccctcaccc acctcccact cttccctcca agtccccaaa 26221 gtccattgta tcattcttat gcttttgtgt cctcatagct tagctcccgc atatcagtga 26281 gaacacgtga tgcttggttt tccattcctg agttacttca cttagaataa tagtctccaa 26341 tctcatccag gtcactgcaa atgctgctaa ttcattcctt tttatggctg cacagtattc 26401 catcatatat atataccaca gtttctttat ccacttgttg attgctgggc atttgggttg 26461 gttccatgat tttgcaattg tgaattgtgc cgctataaac atacatatgc aagttatctt 26521 ttttgaataa tgacttcttt tcctctgggt agacacccag tagtgggatt gctggatcaa 26581 atggtagttc acttttagtt ctttaaggaa tctccacact attttccata gtggctgtag 26641 tagtttactt tccaccagca gtgtggaagt gttccctgtt taccacatcc acaccaacgt 26701 ctactgtttt ttttattatg gccattcttg caggagtaag gaggtattgc attgtggttt 26761 tgatttgcat ttccctgatc attagtgatg ttgagcattt tttcgccatt tgtgtatctt 26821 ttgagaattg tctattcatc tccttagtcc actttttgat gggattgtgg gtttttcttt 26881 cttattgatt tgtttgagtt cgttgtagat tctggatatt agtcctttgt cagatgtata 26941 gattctgaag cttttctccc actctgtggg ttgtctgttt actctgctga ctgttccttt 27001 tctgtgcaaa agctctttag tttaattaga tcccagctat ttatcttttt attgcatttg 27061 cttttgggtt cttggtcatg aaatccttgc tgaagccaat gtctagaagg gtttttccaa 27121 tgttatcttc tagaattttt atagtttcag gtcttaggtt taagtcctta atccatcttg 27181 agttgatttt tgtataaggt gagagatgag gatccattgt cattctccta catgtggcta 27241 gccaattacc ccagcaccat ttgttgaaaa aggtgccctt ttcccacttt gtttttgttt 27301 gctttgttga agatcagttg gctctaagta tttgggttta tttctgggtt ctctattctg 27361 ttccattggt ctacgtgcct atttttatac cagtaccaca ttgttttggt gactatggcc 27421 ttatagtata gtttgaaatc agctagtgtg atgcctccac atttgtcctt tttgcttagt 27481 cttcctttgg ctatgcgggc tcttttttgg ttccatatga ttttgggaat tgttttttct 27541 aattctgtga agaatgatgg tggtattctg atagagattg cattgaattt gtagatggct 27601 tttggcagta tggtcatttt cacaatatta attctaccca tccatgagca tgggagatgt 27661 ttccatttgt ttgtgtcata tatgatttct tacagcagtg tttgtagttt tccttgtaaa 27721 ggtcttttaa ctcattggtt aggtatattc ttaagtgttt tttttttttt tttgcaacta 27781 ttgcaaaagg ggttgagttc ttgatttgat tctctgcttg gttgctgttg gtgtatagaa 27841 gagctactta tttgtgtaca ttaatcttgt atgcagaaat tttgctgaat tcttttatca 27901 gttctaggag ctttctggag gagtctttag gggtttcaag gtaaatgact gctatatata 27961 aagtttcagt ggcacaaaag aaatagcact caaatataaa attttctttt taattctcag 28021 caaggctagt tacttctcta tagaagggtg tgcccttaca gatggaacaa tggtgagcgc 28081 acacttggac gaggggaagg gattcttatc cctgacacac atggcccctg ctgctgttgt 28141 tcccctattg gctagggtca gaccgaacag actaaactaa ttccgaccag ctaatttaaa 28201 gagaatgacg gggtgagtgc tttggaggga gtcagggcag agcaggtagc aggtaaatgg 28261 aatgagttag ggtggagcag gtgattggaa tgtagggtgg agcaggtgat cagaatgagt 28321 cagggtggag taggtaaccg aaaaaggttg ctttacgagg aagttaagtt taaaagtaga 28381 aggcaaagaa ttgaacatac tgacatatta attcttcgaa aagaaattta gaactcatat 28441 ctaacatgat catatcatca gcaaacagtg acagtttgac ttcctcttta ccaattggat 28501 gccctttatt tctttctctt gtctgactgc tttggctagg acttccagta ctatgttgaa 28561 gaggagtggt gagagtgggc atgcttgtct tgttccagtt ctcagaggga atggtttcaa 28621 cttttcctca atcagtatta tgttggctgt gggtttgtca tagatggatt ttattacatt 28681 aaggtatgtc ccttgtatgc cgattttact cagagtttta atcatatagg aatgctgggt 28741 ttcgtcaaat gctttttctg catgtattgt gatgatcatg tgatttttgt ttttaattct 28801 gtttatgtgg tgtataacat ttattgactt gtgtaggtaa aaccatccct gcgtccctgg 28861 tacaaaactt acttgatcat ggtggattat ctttttgata tgttgttaga actggttagc 28921 tagtattttg ttgaggattt tagcatctgt gttcatcaaa aatattggtc tgtaattgtc O 00/09525

EPI-109 910

28981 ttttttggtt atgttctttg ctggttttgg tattaggatg atgctggctt catagaatga 29041 attagggagg gttccttctt tctctgtctt gtaaaatagt gtcaaaagga ttgataccaa 29101 ttctttgaat gtctgctaga agtctgctgt gaatccgtct ggtcctggac ttttttttgt 29161 tggtaatttt cttaattacc atttcaatct cactgcttgt tgttggtctg ttcagggtat 29221 cttatccttc ctgatttaaa ctaggagggt tgtatttttc cacgaattta tccatctctt 29281 ctgggttttc tagtttatgt gcataaaggt attcatagca gccttgaatg atcttctgtt 29341 tctgtggtgt cagttgtaat atctcccatt tcatttcttt cctttttttt ttttttgaga 29401 tggagtctca ctctgtcccc caggctggag tgcagtggtg ccatctcagc tcactgcaac 29461 ctccactcct gggttcacgc cattctcctg cctcagcctc ccgagtagct gggactacgg 29521 gcacccacca ccacgcccag ctaatttttt ttctgttttt agtagagaca gggtttcact 29581 gtgttagcca ggatggtctc gatctcctga ccccatgatc cgcccacctc agcctcccaa 29641 agtgctggga ttacaggtgt gagccaccgc acccggccct ctcccgtctc atttcttact 29701 gagcttattt ggattttctc tcttctttac ttggttaatc ttgctaatgg tctatcaatt 29761 ttatttgtct ttcaaagaac cagcttttca tttcatttac cttctgtatt tttgttcatt 29821 tcaatttcac ttagttctgc tctgatcttg gtgatttcct ttcttctgct gggtttgggt 29881 ttggtttgtt cttgtttctc tagttccttg aggtgtgacc ttagattgtc tgtttgtgct 29941 ctttcagact ttttgatgta ggcgtttagg gctatgaact ttcctcttag cactgccttt 30001 gctgaatccc agaggttttg atagttgtgg cattattgtc attcagtttg aagagttttt 30061 aaatttccat cttgatttca tttttgaccc aatgctcatt ctggaccagg ttatttaact 30121 tccatgtatt tgcatggttt tgaaggttcc ctttgaagtt gatttccagt tttattccac 30181 tgtggtctga gagagtgttt gatataattt caattttctt aaatgtattg aagctcattt 30241 tatggcctat catatagtct atcttggaga aagttccatg tattgttgaa tagaatgttt 30301 tattctgcag ttgttggatg aaatgttctg tatatatctg ttaagtccaa ttgttccaac 30361 gtatagttta aatccattgt ttctttgttg actttctgcc ttgatgaact gtctatggct 30421 gtcagtggag taatgaagtc ctccatgatt attgtgttgc tatctatctc atttcttagg 30481 tgtattagta actgttttat taattttgga gttccagtgt taggtgccta tatgtttagg 30541 attgtgatat tttcctgttg gaaaggcctt ttaccattat atactgtccc tctttgtctt 30601 ttgtaactgc tattgcttca aagtttgttt tgtctaagaa tagctacccc tgctcgtttt 30661 tggtgtccat ttgcatgaaa tgcctttttc caccccttta ttttaagttt atgtgagtcc 30721 ttatgtgtta ggtgagtctc ctgaaggcag cagatagttg gttggtgagt tcttattcat 30781 tctgcagttc tgtatctttt aagcggagca tttagaccat ttatattcaa tgttaatatt 30841 gaaatgtgag gtactgttgc tttcatcatg ctctttgttg cttgtgtact ttggtttttg 30901 ttgtttttgc tttttaactt atatttttgt ttcataggtc ctctatgatt tatgctttaa 30961 agaagttctg tttttatgtg tttccaggat ttgtttcaag atttagagat ccttttagca 31021 gttcttgtaa tggtggtttc ctaatggcaa attctctcag catttgtttg tctgaaaatg 31081 actgtatctt tccttcatat atgatactta gtttctctgg atacaaaatt cttggctgat 31141 aattattttg tttgaggagg ctgaagatag gtccccggtc ccttcttgct tgtagggttt 31201 ctgttgagaa atctgctgct aatctgatag gctttccttt ataggtaacc tggtgcttct 31261 gtctcacagc tcttaagatt ctttccttgg tcttaagttt ggataacctg atgacaaagt 31321 gcctaggtga atatcttttt gcgatgaatt tcccaggtgt tctttgtgct tcttgtattt 31381 ggacatctag gtctctcgca aggccaggaa aggtttcctc gattattccc ttaaacatgt 31441 tttccaggct tttagaattc tcttctttct caggtacact gattattctt aagtttggtc 31501 atttaacata attccagatt tcttggaggc tttgttcata tttccttatt cttttttctt 31561 tgtctttgct ggatggggta attcatagac cttaaagctc tgaatttctt tattctactt 31621 gttcagttct attgctgaga ctttccagag aatttcacat ttctgaaagt gtgtccaaag 31681 tttcctgagt ttttgactgt ggtttcttta agctatctat ttccatgaat atttctccct 31741 tcacttcttg tatcattttt tgaacttcct tgtattgggc ttcgcctttc tctggtccct 31801 ccctgattag cttaataact aacctcctga attctttttc aggtaaacca ggtatttctt 31861 cttggtttgg atccattgct ggtgaagtac tgtaattttt ggggggtgtg gaagagcctt 31921 gtattgtcat attactgggt atctcagccg tggataccag cacctgttcc aatggaggtg 31981 gcggagggtg caatggactc cgtgagggtc tttagttttg gtgatttaat gctctatttt 32041 tgtgctggtt ggtctcctgc caggaagtgg tgctttccag aaagcatcag ctgtagtagc 32101 gtggagaggg actggtggtg tgcagggccc tagaactccc aagattatat gccctttgtt 32161 ttccactacg agggtggata aggaaggacc atcagatggg ggaagggcta ggcgtgtctg 32221 aactcagact ctccttgggt gggtcttgct aaggctgctg tggaggatgg gggtgagatt 32281 cccaggtcac tggagttgtg cacctaggag gattatggct gtctctgctg agtcatgcag 32341 gttgtcaggg aagtggggga aagccggcag tcacaggcct cacccagctc ccacacaaac 32401 tgaagggcag gtctcattcc caccgtgccc tgaccaacag ccccaagtct gtttccatgc 32461 ggagagtgag aagggcttga aaacttgctc aaggctatct gcctcccagc tgtgagagaa 32521 aagggcttta attcttctcc ctgcctgtga agtatgcatg cccaattcac gccctccgct 32581 gagttctggc caggaggctt ctcgccacat tcaaattgtt acaaagttca gctagagaat 32641 tccttctccc tgtggagttt caccccctgc tcctctggcc gatggatccc tgtggtgcca 32701 ggcaggaatg ggctgcttgg gtcccagcaa gttcctgggt cctctacctc tgtatttcac 32761 tcggctctct aacttgactc agctccaggt aaagctggaa acttcacctg caaacagacc 32821 ttcagcctct ccagtggggg tgtgtcttca ggagaggagg gtctaccttt cccacttccg 32881 cagttgggaa actcacagga attttttttt tttaatgtca acagataatt ctacatcttg 32941 gaaaactgcc cttcagaaat gagggacaaa ttaagacatt ccaagataaa taatagtcaa 33001 cattgcatgg gaatttttgg ccagaacaat taggcaagac agaaacaaaa ggcatccaaa 33061 ttggaaagga agaagtaata ttatctctgt ttgcagagga tatgatctta caggtagaac 33121 actgtaaata tttccccaaa atcactgtta gaactagtaa atgaattcag caaaaatgca 33181 gaatacaaaa tcaacacaca aaaatgagtt atgtatctat attggcatta aacaatctga 33241 agaggaaatt aagaaaacaa ttccatttac agtagcattg aaaataataa tattcttaga 33301 aataaactta accaaagagg tgaaagactt gtacacagaa aactacaaaa tgttgctgaa 33361 agaagctaaa gaagacacaa atagatggaa atacatccca tattaatgag ttggaagact 33421 taaaattgtt aagatgtcaa tactacccaa agtgatctac aaattcaatg caatccctat EPI-109 911

33481 tattaaataa aatcctaatt atgtttttgc agaaatagaa aaatcaaccc taaaattcat 33541 atggaaattc aaggaatcgc aaagaaccaa aacaatttcg aaaaaaaaaa atttttttta 33601 acttggtggt ctctcacttc ctgatttcaa aactacaagc tacagtaatc aaaaccatgt 33661 ggcataaaga cagacataca gactaatgga ataataaaga gcccagaaat aaacccttgc 33721 atatatggtc aaataattct caacaagggt gccaagacca tccaatgggg aaaagaaagt 33781 cttttcaaca aatggtgctg ggaaaactgt atgtccacat agaaaaaaat gaagttggac 33841 ccttaccttg caccatgcaa aaattaattc aaattcaaat tagattaaag acctaaatgt 33901 aagagctaaa actataaaac tcttagaaga aaacataggg ggaaattttc gtaacaagat 33961 ttagcaaaga tttcttgtat ctgataccaa aagtacaggc aacaatttaa aattatatga 34021 gttggactcc atcaaaatta aaaacttttg tatatcaaag gacactatca gcagagtgaa 34081 aaggcaaccc acagaatagg agaaaatatt tgcatatcat atatgtgata agggactaat 34141 atccagaata tataaagaac tcctatgact caacaacaaa aaaaacaaac aacctgattt 34201 aaaaatgggc aaagaacctg aacttcaaag aagttataca aatgaccagt aaacatatga 34261 aaagatgttc aacatcacta accactagag aaatacaaat caaaaccata atgaaatacc 34321 atttcacacc ccctaggatg gctattataa aaaacagaaa ataacaaatg ttggcaagga 34381 tatggagaaa ttggaactct tgtgcattgc tgtaggaatg taaaatggtg caaccactgt 34441 caaaaagagt atgacagttt ctcaacagat caaacataaa attaccatgt atattagtca 34501 aggttctcca cagagacaaa accaataggc tatatataga gagaaagata caagagggga 34561 tttattaggg gaattggctc atgtgattat ggaggctgat aagtcccaca acaggctttc 34621 tgcaaattgg agaccttaga atgccagtag catggcccca ttcaagtctg aaggcatgag 34681 aacccagggg gctgctagag tccaaaggat aaagagcctg gagtgctgat gtctaagggc 34741 aggagaagag tgtatcccac ctgcaagagc gagaaaaatc tctctgctat ttttgttcta 34801 tcctggctcc agctgattag atggtgcctg cccacattga gggcaaatct tccccactta 34861 gtccactcac actcacatgc caatatcctc tgtaaacaca ctcacagaaa caccaaaaaa 34921 taatgcttca cctgttctct agttattcct taatccagac aagttgacac ctaaaactaa 34981 tcatcacacc atgggaccta gcaattccac ttctgggcac aaaagaactg aaagccggga 35041 ctcaaagaga tacttgtata cccatgttca tagcagtatg attcacaatg gccaaaaggt 35101 gaaagcaacc caagtgtcca ttaacagatg aataaacaaa atgtgtattt atatataata 35161 tatatacaat aaaatattca gtcttaaaaa ctaaagaaat tctgacacat ggataacata 35221 gatgaacctt aaagacatta tgctaagtga aataagtcaa ccacagaggg acaaatattg 35281 tatgattcta cttacatgat gtacctagag tagtcaaatt catagagaca gaaagtagaa 35341 cagtggttgt taggggctac gaggagggga tgggcagtta gcatttaatg ggtatgaagt 35401 ttcattttgg gaaaataaaa aaattctgga gatgaatggt ggagactggc gcacaacaat 35461 atgaatgtac ttaatgaccc tgaactgtac acttaaaaat ggctaaaatg gtaaatttta 35521 agttatttat attttactac aaaaaaaagg taacatacta aaatgatctc atgggttttg 35581 tgagaatcaa atgagatcca tgtagagaag ccttgtagtc tatatagccc ttcgcaaatg 35641 ttagctcttc ttagtcatta tcactccatt ttccccaatc tgataccatt atccacacac 35701 tttacccagc cacacttacc caacagcaca ctgtttgagt ttgagtgcta tctggtgaat 35761 actcatcttc attttgctaa accctggatg ccatgtgcta gccaacaata tcctattgtt 35821 ctggttctta aacaaaacaa aatctcaaag acttcttcct cttacctagt tttacccaat 35881 gattggcttt gaagcagtcc ttattcagta ataagaggtc accatgccat ggccaagaat 35941 agggcaaatc ttcctccaat tcagttgaac tccctggccg tctagcaaac aacatatctc 36001 ataacacatc ctttgagcag gtgaacaact ctgaaccttc tttgaaggaa caggattctg 36061 ggaaaggaat aaaagaaatg catgcagtgt gtattgagaa taaaatctat tagctaagaa 36121 ataaaaaatg aaaatgctac aacatgatca gttttgatgg actagacaac tctctgtaga 36181 gtagccacag ggctgaaccc tcaaatattc ccagaaagta tagacattgc tgtagaacca 36241 gcctgataat gcagcagtgc agaacttaag aatgatattt ctttctagaa agcagaccaa 36301 ttgatatctt catcctgtta ttgatcagaa tccacgtcag cattcaggtg ctctctggct 36361 acaagtttcc ttagctcttg caggcgctgc tcattgaaga tttctcttaa cacaggtaat 36421 gctaccagtc tcatctggca cctttttcat gcaatgacaa ctatccagga gttgctgcct 36481 ttccagatat cccctgcgag accaatgagg gattttattc catgactctt tgaagaggtt 36541 caaacatgga tcaaacatga agtagtatgt accccagcct tagaaattta atcttttatg 36601 actgggagaa agaacccaag tctctgtgcc ttcacagtct tgaatatctc tgcttgtttc 36661 acttacgttt acctcactca agattcttag tgtcatcgac atgactggtt aagaactcag 36721 gacttttcaa caaagttttc tgccagtgcc ccacaaatca tgactgtggt ctcccaaatt 36781 ctttgattct ccactaggtt ccctttctcc tccattcaaa gccccaaata acatttaccc 36841 tatatattta gtcccgtttt ttgtagaaat gcttctttgc ttgtgttccc cctacctttt 36901 catatcatac ctacatcgtt aactgaggct cagtcataac atcaacaaca gcatgaaaca 36961 tcccaccttc tgtcttcatt ttgctataaa ctggaggcaa aggaaatgct gtcactcagg 37021 gagtatatca atgaagggaa agactctcac aagacaggca ctgaggcagg agtcactagc 37081 acacagtgta taagtgaaat ctaaatataa aaaagcaagc acttgggata catcccttgc 37141 acacacctcc tcttttataa ccagtagagt gaagttggtt gctgaagtca cagaatcaat 37201 agtctatttc ccacagacgg ctgatgatag cagaacaagc cctggctaag tcccccaccc 37261 ttttcttgag tagctcattg ttatgagcca cggacccacc atcaccaggt cacatgttct 37321 gtactctttc ctaaaaacag tgacaaaata tgctgagcca tccatatttc ctcagttaca 37381 ttgagaggca ggagatataa caattaagca gtctctggag ccagagcaac ctgagctcaa 37441 accatgcctt agcttgcttg ttgtgggacc taggcaaagt tactgaaact tctttagaca 37501 tgtttatcaa taaaatgggt acagttgact ggctccaaga tttcttgacc tcttgatgta 37561 tttgccctgc ataattccta agactgtgat tataatggat tttactctta tgattaggtt 37621 ttcacatagc acagttgact ttaatacagg gagattatct gggtaggcct tgcctaaaca 37681 caagagccat ttaaaagcag agttctcccc agctggtcaa aagagagaat ctctggtcag 37741 agattcacag cataagaagg tttcaatgtg ccatcactgg ctctgagatg tagaaaccca 37801 catgtaagga ccaaaaagaa gcccttagga gctaagagct acagccctcc agccaatagc 37861 cagcaaagaa acaaggacct cggtcctaca accacagcca accaaattct gccaacaaga 37921 aaaatgagct tggaagctga ttcttctccc aaagattcca gataagagta caacaccttg O 00/09525

EPI-109 912

37g81 atttcagcct tgtgagatcc taagcaaaga acccactcat gtccacccaa acttctgacc

38041 tacagaactg tgagctaaca aatgagtgtt gtaagccact aagtttgtgg aaatttgtta

38101 cacagcaata gaaaactaat acaatgagga cacagcaagt gcttaataaa tgttagcttt

38161 tattattact aactcattgg gatcagctac acagttgtaa gaaggctaaa gtaaaaatta

38221 tttatgcaag gctggcagtg caacatagca ttcagatcca gggtccattt ggtctaatat

38281 ggctgatatt aagtgtttct caaggggaga gacattattg gcattcagtg gggggagggg

38341 ttcatcctgt agaactgcct tggacatggc agtccattta tcatctctgg cttctcttcc

38401 cctagcagta gtcattgcaa caactgaaaa tgccactgta catttccaaa aatgctcctc

38461 cacaagggtt gagaactttg agaactactt taagggaaat ttcataagaa agcatgcgtg

38521 tcttaaatgc tgccataaag ctacctcaat aactacaatg ctactcaaat tacctgaccc

38581 taagaatcgc cagtggcact tgtttaaata taacgattcc caagttcttt ccctggagtc

38641 ccattccata gggctggggt ggagccccag gaatctatac tcttactcaa agaccccagg

38701 ttaatctttt gtttatgtaa gtttgccaaa cactgagtta gaaatatact cagccgtaca

38761 tgcatttagc aaaagttcac cacaacggaa caatgacaca ccaaaactct ttgaaactgt

38821 gccttctaca gagctgtaaa tctccttttg gaccattcca ttacacaagg tgtcctcttg

38881 gtcacacagt gattgcaaat gggactctag agtcatggaa atgggtatac tcttctcaaa

38g 1 ctttccatct ttaccagaat tacttcttaa agtgatatgc ttcatggtgt aaactagcac

3gooι ttattaattt tttctaaata tttatcatat ttcatatact tttattttgg agatggagtt

39061 tcgctcttgt tgcccaggct ggagcgcaat ggcagatctc ggatcaccgc aacatccatc

39121 tcccgggttc aagcgattct ctggcctcag cctcctgagc agctgggatt acaggcatgc

39181 gccaccacgc ccggctaatt ttgtattttt agtagaaaag gggttctcca tgttggccag

3g241 gctggtctcc aactcccgac ctcaggtgat gcgcccgcct cggcctccca aagtgttggc

3g301 attacaggca tgagccaccg cgcccggccc atatactttt aatacatgtg gaattaataa

39361 aaacgtccat gcctccaatt ccgtggctat tttaccgtct tcctttttcg gacaagtccc

39421 tcaaaggtag cgctcttggc tccttccttt gcttatcccc taaccctgtc ctcctgaggt

39481 gccccctgga tttcctccaa ccccggcagg gtctgccttt ccgggatgat acaacgacct

39541 gccctgcatg ccatatccca ggcgcgtggg caccaaagtg tggaaaaacc gatgaatgac

39601 gttttctgtt tccgatactc tgcctgccag aatcccctgc cgcaccgccc caccacgaag

39661 cacatggaac ccacggacta cacgaggaca gaggtctgtt ctccctttac ctctcccatt

39721 tctttaacta tgcttctctc ggctggcatg ccctttcctc atctcactcc acacacgaac

39781 aggtttagca aataatatgc acgctgctgg gacgggccca agcatttccc tcccttgata

39841 gggcggaact aaaatgcaag ccccacagtt gtcagcaaag gacttccctg ttaccatggt

39901 aaagccgctg cgcctttatt gtggttgagg agtacttgca tcaacctaag agaaaattaa

39g61 taagaaggaa gtctgcaggc tgaaaccctt caaattagcc tggactcgcc tgcatctggc

40021 tcggaacaga gttaatctca ggagtgagaa tatagccctc cggtggacgc aactcgcgcc

40081 tgcggctaac agaatgtctc caggggaggg gctctgcgtc cgttccgccc aggcccttcc

40141 ggctcacgcg ccgtacggaa gcgtgctcag cgctgggctt gtgctccgta cggaagtgtg

40201 ctttggcgca ccggaagccg actcaacaga gctatggcgg gtttgactgt gagagaccca

40261 gcggtggatc gttctctacg ttctgtgttc ggtgagagga attcgttgta gtcaagcttc

40321 ggggagggac tcccctctgc accttctatc tcatgaatcg ctaccggagc cgctgacggt

40381 tcggacgtgc agttctccct gcttatcctg tagggcgtcc aacctggtgg actcatgagc

40441 aaagagatat tcccattctg ccgaggtctc gtaggctttc cgcaatatca gtggggaagt

40501 tagactagcg ttcagcttct gtgcgtttct cctttcatga gcttcaatta ttctctagag

40561 gagaaggctc acggtaacag ctcctcactg tcccgtacta cttctcatcc tctgccccag

40621 aatacagact atatgctgag ggtatagatc ctagtgtcca cttactgtcc tctcctaagg

40681 actttcatcc tttgcttttt atctgtaaca ttttagtgca tcaatagtgg tagcggccac

40741 ctggtgtcct gagatggctt gtaagtgaat gaatgaatga actattaaga tctcctcaga

40801 ggaattttaa aaaggatcga aacgattctg aattatcttt ttggctgaaa taagttgttt

40861 ttaaaaatac gtgtgattat tttagagtac catttgaaag ggacatgaca aagtagttca 0 21 gaatactttt taaacatctt tcactacatt catcgtcatt ctcccttaaa tgttgtatgt 0g81 gtggaaatac ataggaacct gttttaaaaa ttatattaaa taacattgat attttttgta

41041 gtcactgatg agacttgcag atctttaggt aaataccagt gccaaagtat ttatttgcac

41101 caaagttaag gaaaatctaa cacgtgtcag atcagtctga gaactaacat ttgagagtac

41161 ctacacattt tgtatttagt ttcagtggta tatttccttt gttaagaggt ctgaagaaat

41221 acaatggaat tgggattgga gaacactatt ttgagtctta tatttgatga tataagttta

41281 ctttctcact aaagatctat gttataaact cagaatttta atgttaccta ttttcttcct

41341 tagtggggaa cattccttat gaagctactg aagagcagtt gaaggacatc ttttctgagg

41401 ttggacctgt tgttagtttc aggtgagatc cccttttcct tcatggtggg agcttcttaa

41461 aaatcaccac agatttggct cttagtaata atggcaggtt ttctttactg gtgacttttc

41521 acatacattt tgttcttgta acagctttat tgagatataa ttgatacact atacaattga

41581 catttattct tacctaaaat atgttttttt cgttaaaaat gttttttagg cagggcatag

41641 tgactcaagc ctgtaatccc agcactttgg gaggccgagg caggcggatc acctggggtc

41701 aggagttcga gaccagcctg accaatgtgg tgaaaccttg tctctactaa aaatacaaaa

41761 attagccgcc gtggtggccc atgcctgtag tcccagctac tcaggaggct gagacaggag

41821 aattgcttga acccgggagg cagagatagc agtgagccaa gatcatgcca ctgcactcca

41881 gcctgggcaa cagagcaaga ctccatctca ggaaaaaaaa aaaaaaagtt ttaaaaaata

41941 tttctgtgag gctgtcagag atataaggtt atttatgtta cagtgggccc aattaaagca

42001 tggcaatgtt agcaggaacc ctgtatgtgt gtaacatttg ttcctgacac ttggttctgc

42061 tctccagatt ggtatacgat agagagacag gaaagccaaa gggttatggc ttctgtgaat

42121 accaagacca agagacagca cttagtgcca tgcggaacct gaatgggcgc gaattcagtg

42181 ggagagcact tcgagtggac aatgctgcca gtgaaaagaa caaagaagag ctgaagagtg

42241 agtacaaatc caacttggat gcagtatgag ttagtaaaga tgtaacaatg aagattttcc

42301 atttctgata tgttttagaa tatgctgaaa tggttagcca cgcagcttgt ttattacttg

42361 actgacctga tgtgcctgag ttaggcaagt attatatata tctttttaaa aactttttat

42421 aaattttttt tcaagtaatt gtctgaaatt tctataccct tgctctggat ggagcagggc O 00/09525

EPI-109 913

42481 aaggcctcaa accgtttcaa aactgttctg gcaagcactg tagggatgca tagggtcact

42541 gcagacctaa gcatgctgga ggcttgctag taagtgtata tctttaagaa acagataaag

42601 ttgacattag aaattcttca gttgctccag cctgggcgac agagtgagac tctgtctcaa

42661 aaaaaaaaaa aaaaaaaaga atttccattg ctaaggagtt atttccagtt aaagatgaat

42721 tcaaattcat caagccatta gtagtactaa ctgtggcatt agtcattcct gtcactcttt

42781 tcaggaattt ttgaagttag cgtatttttc tcttttaacc ttttgtttct gaaatgactt

42841 gttaaaagaa gtcaatgtgc ctagttctct aacttaggtt aacattgtcc ttccatgtga

42901 tcatgatccc cagctttcct ctgagaacag aaaatacact ctcactttcc tccacagaaa

42961 caagaggctt tcacatcatt tatttctcag ctctggagaa tctaaaatta tcagctggtt

43021 cttacagcag ccctgaaaag tagatatttg aaatgattta gctttttgtt ttgcctccct

43081 aactttcttg tactttcttc ttgattaggc cttggcactg gtgcccctgt cattgagtca

43141 ccttatggag agaccatcag tcctgaggat gcccctgagt ccattagcaa agcagttgcc

43201 agccttccac cagagcagat gtttgagctg atgaaacaaa tgaaggtggg aggaggcatt

43261 aggttatgaa taaagcaaat cacatcaggt tttcaaggag ttacttgaat tagttccctg

43321 agctcaaata gaaattgtct gtagaccacc atttcttgca ccttcaatat tctgtatgta

43381 cacagtatat tttacatttt gtacaaagag ctttctattt ttgtacacaa acacagctat

43441 ccaaacaatc cagctggagt tttgtggccc atagatgtca gatgtagata ttaaaatttg

43501 gcttttttcc taaatgataa tatcacagta tttgaaatgc ctctttcttc tcttgcctgc

43561 catgaccaag gtttttttgt gccatgcaaa aactaatgat aaagagcctc ttgaatatta

43621 catttctcag aggggaatgg ctctaaatca ctatcagttt ctaagtcata agtattaaac

43681 ctgaatctgc ttatcttctc agctctgtgt ccagaatagt ccccaggagg cacggaacat

43741 gttacttcag aaccctcaac tggcttatgc tttgctgcaa gcacaggtag tgatgagaat

43801 tgtggatccg gaaattgccc tggtgagtgc ttctggttct tttatggaaa tggtcgggta

43861 aaccttgaat gggataggaa ctacctgatt gctttgttaa acagacagct cataggtttg

43921 tcttttcact ttttagaaaa ttctgcatcg ccagacaaat atcccaacgc tgattgcagg

43981 caaccctcag ccagtccatg gtgctgggcc tggctcagga tccaatgtgt caatgaacca

44041 gcagaatcct caggcccctc aggcccagtc tttggtaggg ctttatccct taacattttt

44101 ttgtatctgt cttagaatgt cattttcttt ttaggagaat atattgaaag aagaatggtc

44161 aggaaccaga gatgataatt tcaatttcca ggcataaaag caatttccag gttgcagagc

44221 acatgacatc tgaatgaata tagattcgat tccaagtttg taaaacaaag agatccttcc

44281 cgtatgccct tttcttataa gctaactttg tgtgtatgtg catgcctggc actgtggttg

44341 gcacttcgtt attccatatg cattatctca tttaatcctc aaagcaattg tatgaggttg

44401 gcactcttat tatctccatt cttactgatg aaaaaagtaa agcttgcttt caaagcatga

44461 cacaaaacct taaagccata aaaaattgat acatttgaaa actaaaaaat ttctatataa

44521 agaaaaaaat aagtatcaaa gacatgacaa attgagaaaa agtatttacc acacatgtga

44581 tggaaaacag actaataaag agcccatagt cattcacaag aatgtttatt gccttagagt

44641 gaaaaattgg aaatgtccta aatgtacgtc agtggaagaa tggagaaaat gtgtggtaca

44701 ttcatccagt gaaatactgt acaacagtta aataaactac acgtatcaac atgaatgact

44761 ttgaaaaaca taattccata cagcagttaa gatgaactag gatacataat atcaacacaa

44821 ctccaaaaca gtgacatacg gacatgaaac taagtgaata tggatgcatt cccgaaatgt

44881 aggatatatg tttctgcata aatccccaaa atatgtggaa tgagttgcaa aataatatat

44941 tgagtatgta atgattcata taaaattttg aaacattaag aagacgtctt agtggtcatc

45001 aaaggagaag agagcacagg atgcaattgg ggaagaccgt acaggccatt ggtttatttt

45061 atttacttat ttatttccta agctgggtgg ctattttatt ttctatatga tttgtatatc

45121 tgtaattttt cataataaat tttaaaaggc ctcctataaa ttagtaagaa aatttccaat

45181 aacccagtag aaaaatggga aatagacata aatatttcac aaaaggagaa atataaatat

45241 ataaaaattt attcaacttc aaaataagat aatgtaataa attatcattt atatatgtaa

45301 tgttataaga taatgtaaat agaaactaca ataagctacc atttttcatc tctcaggttg

45361 gcagaggtac agggcaggga ccagcaaaca tttttctgta aatgatcaga cagtaaatat

45421 ttttggcttt gcaagtcaca ggatctgcca cagctactct gccatggtag tatgaaatca

45481 gccataggca ataagtgaac aagtgtgtgt ggttgtgttc cgttaaaagt ttgtttataa

45541 aaccaggcag tgagcccgat ttggcccatg ggtcatagtt tgccaacccc tgctctaaat

45601 aaataaatac attttcagag atagaaaaaa aaagctaagg cccagagagg ttagctggtc

45661 caaaaattga cacaattata agtggcagat ctatttctga acctggtttt atctgacctc

45721 acagccagtt ttctcttaac tactttccta tacagctctt ccttttcttt tgtagagttt

45781 ^■tgtgttcctt aaacgtatat gtgatttttt ttatataact tggcttttat tctttattta

45841 ttgagctgtt tctaattcaa gggactactc agttttttgg ggaatgcaca gatgaaaaga

45901 tgacattctc tttttctcaa cgagttttaa tgtagcattt aaaaaaatat atttcacatt

45961 cccccaaaac cagaattata tctaaggaca ggagtgagaa aagattggtt aaattaaaaa

46021 aaaaatttaa ttttaaaaat gtggactacc agcagttgtt ttttttaaaa gagtcccagt

46081 ctccttttat gtttcttggg tttagggctt tttttttttt ttttttttac tcttattggc

46141 agccccaatc atgaagttaa cagtaggtgt tatgtgctgc cttgccacac agataagact

46201 tgtcaatctc tacattgaga atatgttcca tcttaaccgt gttccatata accaggctca

46261 tgacgtatat tgcttctgtg gagtttaaag tgtgtgacaa atctaatgct gcataagaca

46321 tgccatacaa aaaggatgtt tagtagtgta tttggggctg ttcatttgaa gaggactttt

46381 aaggtcgtag acttagtata ttgagtatcc acagaggcat atacatactc tgtttttttt

46441 gcttggtcag ggtggaatgc atgtcaatgg cgcacctcct ctgatgcaag cttctatgca

46501 gggtggagtt ccagcaccag ggcaaatgcc agctgctgtc acaggacctg gccctggttc

46561 cttagctcct ggaggtaagt ttcatttagt cttcaccatt tcagtacttg ctaaagtttt

46621 gtcatagcca ctgttgcagt gcagccaaat atgataatgg gatccttagg taaaattaat

46681 acacagctag aaagtatata tcttaggtgg aggaaatagt agatttctta cgttaaatcc

46741 tgtatgtcta attataagaa cagggaaagg gacagtaaag tgaaagagca tagtaaaact

46801 tccaagttaa caagggggaa aatggaatga gtggaaacaa aatcaagcca gcaaaaatag

46861 agaagaggaa aaaagtaaga gacagtgtaa aataagtaat aataaatgta gagtaagatg

46921 gaaggaataa aaactaatgt agttgttact ctgctaaata tgaatgaact gtcagattag O 00/09525

EPI-109 914

46981 gttcaaaagc tcatgaagaa aacagacaaa aaaatacaag gtcacatttg ttatagcata 47041 ttaaactgac ataaaattgt attttaacaa acataatcag aacaaacaac aaaagggaaa 47101 aagagaaatt taaaagctat gtacatttat tgaaaatgta tagatcggca attaataaga 47161 gtattgctca tatacttgta actgttcctt gttcaacaat tgtaactaag aagattgagt 47221 gaaataatga ttccccatat gaaacatctg tatgaacaca tgatgtatta ccaatattta 47281 aagttttttt atgtaacaaa cttggttttt gttaatttat ctaatctagg gtaggttgag 47341 tacaacacta ctcatggaga atgatttaat tctaaattgt tctgttctgt agagaatcca 47401 gtctgcagag ctaagttgat gaggaatgga agaagagatt ttttgaagaa atttctgcaa 47461 actcaggaat tttttgtatc tactttagga ttgttatgta tctactttat cctaatagag 47521 ttatacttgt atttaaatta tctttcatga caggaggtcc atgggtaagt gacattgttt 47581 tcctgtatta tagaagagct tcctgccaag agtttggtaa ccaatgaaat gaattattct 47641 tattgaactc actattctgt cactgaaaca taaagtacaa attgtaaata tactaacaaa 47701 ccccatcttc tctctcattg cattgttgaa tatcttcctt tgtaggtttc tgcttgtgga 47761 gcagaatgag gaaatttgta aactcagcca ctgttctaat ttttcttttc cgctgttcta 47821 attggtgttt tttcttgtct gccctttatc ttctaggagg aatgcaggct caggttggaa 47881 tgccaggaag tggaccagtg tccatggaac gggggcaagg taaataaata ttaatgtctg 47941 actaatgtta attggtcatg gaagtgttcc acatccacag tatctaatat ggcagccact 48001 aaccacccat ggctatttca atattaagtt aattaaaatt aagtaaaatt taaaactcag 48061 ttcctcagtc acaatagcca cattccaagt gctcagtggc cacaggtgac tagtggatac 48121 catacaggac attacagata tagaacattt ctatcatcgt aaaaagatct attggacagt 48181 gctggtctag actttccacc tggtgattca gagtccagct ctacaagaat tgataatgaa 48241 gcaagtggat cgtttgtttc ctgattccta gtctaataat tccactgaca tgttctctct 48301 ccctgtatgg atatctgttg actgagtaag gaattttaat aatgagcatg taaatatgtg 48361 gctgggtatg tagaagacta gatttaaacc ccagagaaaa ctgggaggga atcataggtc 48421 tgtaacgcct acttaatgaa catatgttgt accgtggctg tactgctata tacaacagta 48481 gctgctgctc caaaatctcc atgttgtttc ttcatgttac tggagtttga aggacaagaa 48541 agtgcagtgg ttcagttgga aacaatgtta ggaggagaga tcgtaagaaa agagaaggaa 48601 ctgagtgcat actatatgcc aggcacttta attttcataa ataatcttgt gagttaggtg 48661 gcagcacctc agttttacag gcaaagagtt ggaagctcag aataagttac tttctcaagg 48721 ggacaaggta agtaaatatt aatgtatgag taatgtggac tggatttggt gctcttattt 48781 tctcttccaa ctagtaagtg gcagagctaa gattcagaag tctttgactc cagaatctgt 48841 cctctttctg tcactccaca ctgcctctgt taacttccaa gcatattctt cagtgtcttc 48901 tactcttatt ccttgggaat aaaatgatgg gaaagactgc tttggacaag catagagaag 48961 cttaaggttt tttcttttgt agcatatggt ttataagtgg aacccattta aaaagcaaaa 49021 tattggccag gcgcagtggc tcatgcctgt aatcccagca ctttgggagg ctgaggtggg 49081 tggattgctt gagctcagag gtttgaaact agcctagaca acatggcaaa accccgtctc 49141 tataaaaaat acaaaaacta gttgggcaat ggtggtgtgc acttgtggtc ccagctactt 49201 gggaggccga agtggaagga tcacttgagc ccaacaggtt gagactgcag tgagccataa 49261 tcgggcacca ctgcactcca gcctgggcaa cagagcaaga ccctgtctca aagaatatat 49321 atatatacac acacacacac atatatatac acacatacat acataaacat taatatacaa 49381 gcctgtggtt tttacactgg ggttggttgc tgaagtgaca gaattaactt tttcttgtta 49441 gaagtctgac agcaggacaa actccctggc caaatatctc atattttctc taagcatcca 49501 atgcttttgt gctattgtac atccctctat ccccaccgca ccactgtcaa tagatcatat 49561 atgttcccca gagtatttct gcagtaatga gaaggtatta gggtttcagt catacttctg 49621 cctgtcatgg ggccagccct caatccatca ggttttagct gtttaacgca tacttgcaca 49681 agacatcttc ctattatagt tatcttcacc tttttgtcag aaattggcaa agggaagtga 49741 ctcatgtttt gagggtattt ccaggatgtc ttcatgcaga gactaagtga gatgagcttt 49801 cttttatagt ttccttcagt acccagcaga ggaagcaaga gtcttttcgt gtgtgcctag 49861 tttgtcttac ttttcctgaa atccatgctg cttttaatgc tgaaaggaga tggagatgtt 49921 tgagaagata cttcttgctt ccctgccatg tttgtttagt gtcggttccc atgtcatctc 49981 attagtcttt gtttgctgtt gtcatgatgt ttattatcaa agacttgctg tggcagagta 50041 tttcttgtgg agtgatattc tctttcatca tgtaaagttc attcactgca tttccccatc 50101 tgatacattt ttgacagcag aaatttttgt gctttaaaat gtgacaaaaa tagaattgcc 50161 gtacttcagt tatggccgtt tcagaatgaa tcttgccttc cagattcagt gcagtttctt 50221 ttatgttttg cttctgaaac tacatttatg ttctttgcat aactagaaga ttcaaaacta 50281 tcctttttat atattttttt cctaatgatt tcataaggag acctaacgga aaactagtag 50341 cagaggtgaa aatcgaaaat gtcaggttat tcccacctag atcaaaccag tgcccccatg 50401 ggattccctt tcaaaagcta tctggtcaaa atggaactat ttcagagacc caaaggagct 50461 agtgtagttt agggagattt tgtagcctgg agcaagccga tgaactcttg gctttttaac 50521 ttatatatgt aaatctcaat ctccatgtgt gtgtgtttct gcgtgtgtat gcaagctatt 50581 ttaagtgtct gctctttctc cttttgaact tactgcttac ctaggaaccc tacagcactc 50641 gcccgtggga cccgccgggc ctgcatcaat tgagcgagtt caaggtaccc attgtatctg 50701 tgggtttcct tttgcttgtg gtgttcaggg tgggacgttg agaggaaaag agctgcgtgg 50761 cagtcatcct cgcgttcaga acccaaaagg gtagtgtttt tgggtttttg tttttttaat 50821 tttttcctgt tgaggccaca agcctaagat tgacctcttc acacagggca gagaacatgg 50881 atgatatggg catctgtccg aggctgtact ccctccctac tggtgtcagg aggcttggat 50941 ggaatagcag tctgtaagga gacagcgggt tcttgcagag ccatggcagt gttcacatat 51001 gccaagactc tacctctgtt ttgtgactct ggtccttgaa ctaagattga ttagaaggaa 51061 aaccaggagc ataagtttct ccaggtcgca gtgctagtcc ttggcaggtt gctccccagt 51121 ttgctcttta tataattcca tccatacctc tgacatggca cagattctgc ctacaccctg 51181 cttctgttct tgagctgcaa gaggattctg ctgtggtgag gtttcaccca ctctaaggtg 51241 tctgaattat gttgtcagtg gtatatagag tcatttcttg tttgcttatg tgtctttcac 51301 agcagtaact ccccgtttgt ttccctgtca gtgccgatgc aagaccccag agcagctatg 51361 cagcggggat ccttgcctgc gaatgtccca acccctcgag gcttgttagg agatgctccg 51421 aatgatccac ggggaggcac tttactttct gtaactggag aggtagagcc taggtaagca EPI-109 915

51481 ctaacataga aggaaacagt tgaagaaatc agaattgtcc cttcttccct gagaacaaaa 51541 tctttctgta ccagttgtac ctgtttgcct acttcaaaag gtagatcaat attcatggcc 51601 actgtccaag ggtaagcact tctcctaagg cagaactatg tacttgagta tgtcattttg 51661 agctattata tttttagaaa ttggaaattt tagtatacat acttgaacag ggaaatttat 51721 agtagtggaa atattaataa tagcaataat aggccgggtg cagtggctga cgcctataat 51781 cccagtactt tgggaggcca aggtgggtgg atcacttgag gtcaggagtt cgagacctgc 51841 ctggcctaca tggtgaaatc ccatctctac taaaaataga aaaattagcc gggcgtggtg 51901 gcgggcgcct ataattaca ctactgggga ggctgaggca ggagaatcgc ttgaacccag 51961 gaggtggagg ttgcagtgag ccgaggtcat gccactgcac tccagcctgg gcaacaagag 52021 tgaaactcca tttcaaaagt aaataaataa ataaaataat gatagtaata ataattgaca 52081 ttaatgggga tcatgcctct gactctgctc tgagtacttt acttagatca tcttattaaa 52141 tccacaagat cctgtgagat ggataccatt attagtccca ttttacacgt gaaactgatg 52201 tgtggaaaag ttaaataatg tgtccaatat cacacagcta ataagtgata gagcctagat 52261 ttgaacccat acagtctgaa tccagagctc atgttcttat gcattgttct gcaaactcat 52321 acatataatg aatattcgtt gattcctccc taattatgaa ccaaataacg aaattctaga 52381 atacatggat ttatatctct gtagcttttc ttccatctat ttggtgttat tttcttgtta 52441 gtattcatag actacatcag ctctttgttg gatgtttact tactgatctg gttggtactt 52501 tgttgttgtt ttgttctatt ttaaaataca acgtttttct ccatctccag aggttacttg 52561 ggaccacctc atcagggtcc acccatgcac catgtccctg gccatgagag ccgaggacca 52621 cccccacatg aactgagggg agggccatta cccgagccca gacctctaat ggcagaacca 52681 agaggaccca tgctagatca gaggggtcca cccttggatg gcagaggtaa ggggagatca 52741 cattgcaaat gccataatga actcaactgt cttaggctct aatctgggat aaagaatgct 52801 ggaacagtag gtttgcaagc atctttaagg tttatccaca aatctgagaa actggggagg 52861 agacaatagt ctcatatgtt aatagctgag gggacaaatg tgactagaag agatttctat 52921 ctttcttgga ttgttcatca ttcttgcagt acatgcaagt agctacataa tggttttgtt 52981 acatttttct ttataggtgg aagggatccc cgaggaatag atgcacgagg gatggaggcc 53041 cgagccatgg aggcaagagg gttagatgcc agaggattag aggcccgtgc aatggaggcc 53101 cgtgcgatgg aagctcgtgc aatggaggcc cgagcgatgg aggcccgtgc aatggaagtc 53161 cgagggatgg aggccagagg catggatacc agaggcccag tgcctggccc cagaggacct 53221 atacctagtg gaatgcaggg tcccagtcca attaacatgg gggcggttgt cccccaggga 53281 tccagacagg tatgtgtaac actgacttct ggcatccaag tgaaatcttg atctattcag 53341 gaattgatta ttgagcctaa ttattactgc cttctgactt gggctgtttc ttagcttgtt 53401 agaaagggaa gacttggatc tccctgtagc ttctctgtcc cttagggtgg tgattttctg 53461 gctatcagga ttgtagttca aaaaaaaaca accttatccc acaataaata gctattcatt 53521 tggagcagag cccctgaaaa tttaggggtt agaaagtagt cttgattggg gtacaaacca 53581 acatcatgta cacggttttt tccaagatat acttgcccgg atctcatccg aggtataact 53641 cagaatctct tattagtagg atctgagcat ggatagtttg aaaaacttcc cccaaatgat 53701 tctaatgtga accctgactg ggaaccactg ggttagagta tatgaagagc tgttagtggc 53761 catttagata atcttaggtt tagagagacc tgtgttaatt tattgtcatc acatagccta 53821 agtgaacagt ggaatgtgaa aggcagttta ttaataatca ccttaaaagg tgtggaaccg 53881 aagtcttgtc tcctctcttt tatttggatc tctctgcctg tgtgtacatg ctccctcttc 53941 atctcgactt ggttgtggag aggtggtatg tgtgtttctt ccgtgagttt ttatatgctg 54001 gcaccttcat ttccctctaa ctgctccacc ttccttttcc ccccttcctc tgcgtacttc 54061 tctcttcttt ttttatgtgt cttcctcccc atgtctgtgt gtatgagaga gagaaagata 54121 atggcagagc tggaatggaa tacatcaatc atctaattcc ctcagtttat agatttggaa 54181 attaaggccc aagaattcag gtgacttgac caaattcaca tgactaaaaa gtggcagagc 54241 aaggaacaga agccactact ttttccactt tactactctg tcctgttatc tgcacatttg 54301 tgtgtgtgta tatgtgtgga tatgtgtcta ccccctcctc tgtaatatga aatacaaata 54361 gagggttttt ttgctatgtg tagaataaaa ctgttctcta ttgtgtttga agtgtttgtg 54421 ggccttgatt tttattgtac tctctatggt cagtagccta gtaacagaaa tggtttttat 54481 gcattcattc tgtcactcag caaatattta ttgagcacct actatgtacc aaacatagat 54541 ctaggtacgg gggatactgc agtgtgaaca gaacaaagcc ccttccccca tgggcttaca 54601 ttctagttgg gaagacagat aacaaacaaa taactacata atgcgcttac ataattttac 54661 tggtagttct atgatgcaag acattgcaag taagggttgg aagaacattt ctggataata 54721 ttttgctcct ttctctctgc tggtacttga acttattacc ctaatactag gtttatacca 54781 tttttattag tagattcgat aaagccaatt agatctgagg caagagaaaa tacaaatttt 54841 atcttcaaac ctttaaaaaa attttaaatt aatatattaa cttataaata tatatattcg 54901 ttcatctata aaagatatat gtattaagaa cttcaagcca ggcatggtga catgcacctg 54961 tagtgccagc actctggagg ctggggcagg aagaccattt aagtctagga acttgaggct 55021 gtggtgcatt ctgatcgcac ctgtgactag ccactgcact ccagcctggg cagcatatta 55081 gactcccatc tttaaaaaaa aaaaaaaagc cagggtagaa tcctgtagtc ccagctactc 55141 tggaggctaa ggcaggagga tcagtagagc ccaggagttg gaggcccgcc tacacaagat 55201 agtgagacca catcttaaac taaaaggaac cttgcttcct ctcctatgct tgtctcccct 55261 gtggccctct aggtcctgta gataatcact tttattagat ttttcatgtt actttctgga 55321 aaacatgaat atatattat^'t tttccccttt cactgttcta tacctttttt ttttttaact 55381 taacaacatg tccttaattc atacttttaa attagatttt aaaattaact ctagtccact 55441 tagttagaaa cttgtgggca aaaggcttat tattactagg gtgattatat aatttatcat 55501 ctaaaggaga acatgaaaga aagtgctgtt actttacttg gaggcaaaaa cataaactgg 55561 gactatctta gggaaaccaa gatgtatggt cacttttgct agtacttgtc tgcctagaac 55621 aagcacacct agaaacttaa aatggccgtt attgagtggt tagatcacaa ttacagtacc 55681 tcagattaaa gcttcaaaaa gattatactc aattccgaat tgtgctgcta taaactcatg 55741 tgaccaaaca ccacctgttc cccaataacc tatggaaata aaaaatttta aaaaaaaaga 55801 ttatactcat aggtgtttca gacccataat agctcgttaa tgttcagact ggtctctgga 55861 aacttgtctc tggtttcagt attgataatg aacagaacag tgataatatt ctagcagtct 55921 atacaaatct gtactaatgt ttcatctatc cattgtcttt gggaaatgag ttaatgcatg EPI-109 916

55981 taagtgaatg ttccagataa tagaactatt ctaccaagtt ttttaacttt tttaataaaa

56041 aattataaaa agtatttgat atttcctttc ttgaacagga tacaaaaaaa tagtttaatc

56101 agttttgact actcaaggtc atcattgaat agattcatta ttgtctatac cgtaatataa

56161 aacatagtta tctcctgttt ggtttctggt ctccttcact gtcaggccgt cacctggctc

56221 ttcatattac tgaagtggta tctgctccta acagttattt atccgtattt cttttatgtt

56281 ttgctgcttc taatctgctg ggtaagcagg taacaagttt gttaacaata tgtgtttatt

56341 aagagagtac ctaagctctg ggtgaatgcc tgagtgtgaa cataatgctt gtatagggac

56401 attctaacag ttagatttgg tactcaagag gtcttttcct tgggttctgg tagtcttgca

56461 aagggttgaa ctcattgaag atcttaagta ccagtaagta tgatatcact gtacttggtt

56521 ttttcactcc agtcagtcat attttttggt ctacatttag cagaaagcat ctgccatatg 56581 ttc

(2) INFORMATION FOR SEQ ID NO: 2693: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2693

1 ttcagttcta gcgtcaaccc ggtgctctac gtcttcaccg ctggagatct gctgccccgg

61 gcaggtcccc gtttcctcac gcggctcttc gaaggctctg gggaggcccg agggggcggc

121 cgctctaggg aagggaccat ggagctccga actacccctc agctgaaagt ggtggggcag

181 ggccgcggca atggagaccc ggggggtggg atggagaagg acggtccgga atgggacctt

241 tgacagcaga ccctacaacc tgctgccctt ccctgtccct ttccaccccc cacccaccct

301 ccagaggtcc tcccgacggc catgaacact acatcttctg cagcaccccc ctcactaggt

361 gtagagttca tctctctgct ggctatcatc ctgctgtcag tggcgctggc tgtggggctt

421 cccggcaaca gctttgtggt gtggagtatc ctgaaaagga tgcagaagcg ctctgtcact

481 gccctgatgg tgctgaacct ggccctggcc gacctggccg tattgctcac tgctcccttt

541 ttccttcact tcctggccca aggcacctgg agttttggac tggctggttg ccgcctgtgt

601 cactatgtct gcggagtcag catgtacgcc agcgtcctgc ttatcacggc catgagtcta

661 gaccgctcac tggcggtggc ccgccccttt gtgtcccaga agctacgcac caaggcgatg

721 gcccggcggg tgctggcagg catctgggtg ttgtcctttc tgctggccac acccgtcctc

781 gcgtaccgca cagtagtgcc ctggaaaacg aacatgagcc tgtgcttccc gcggtacccc

841 agcgaagggc accgggcctt ccatctaatc ttcgaggctg tcacgggctt cctgctgccc

901 ttcctggctg tggtggccag ctactcggac atagggcgtc ggctacaggc ccggcgcttc

961 cgccgcagcc gccgcaccgg ccgcctggtg gtgctcatca tcctgacctt cgccgccttc

1021 tggctgccct accacgtggt gaacctggct gaggcgggcc gcgcgctggc cggccaggcc

1081 gccgggttag ggctcgtggg gaagcggctg agcctggccc gcaacgtgct catcgcactc

1141 gccttcctga gcagcagcgt gaaccccgtg ctgtacgcgt gcgccggcgg cggcctgctg

1201 cgctcggcgg gcgtgggctt cgtcgccaag ctgctggagg gcacgggttc cgaggcgtcc

1261 agcacgcgcc gcgggggcag cctgggccag accgctagga gcggccccgc cgctctggag

1321 cccggccctt ccgagagcct cactgcctcc agccctctca agttaaacga actgaactag

1381 gcctggtgga aggaggcgca ctttcctcct ggcagaatgc tagctctgag ccagttcagt

1441 acctggagga ggagcagggg cgtggagggc gtggagggcg tgggagcgtg ggaggcggga

1501 gtggagtgga agaagaggga gagatggagc aaagtgaggg ccgagtgaga gcgtgctcca

1561 gcctggctcc cacaggcagc tttaaccatt aaaactgaag tctgaaattt ggtcaaaaaa

1621 aataaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

1681 a

(2) INFORMATION FOR SEQ ID NO: 2694: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2694

1 gatcaaaatt tttacctatt atgcatttga tatataaata agtatataaa tgcacacaca 61 gacacagcaa tgatggtgaa cagtcttcat acaattatat ggatgaatct cataaaatgc 121 tgagttaaag aaatcagacc aaagaacata tactgaaaga ttctctctat atacaaagtt 181 caaaaatagg tggaccaatt catggtggtg ttagaaatca gaagagaggc tacctttgtg 241 gggaggggac agtttaatgc ccagaagcgg taaataagga atcctctggg gagtggtaat 301 gatctggatg ctggctacag gatgtgttgg ttgtaaaaat gcattttttt atatctagct 361 ttttccatgt gtatattata cttcaaagaa gttcagttaa taatttctca tgtcactgta 421 gagtagctca gttagcccca gcaagcctct ggcttaatct tgttttacct taagccatca 481 gtcatttaca agtaggaaaa ttcacaggga aagttagagt ataaaatcca gaatgaaggt 541 ttactgggta agagtctctc cattttccaa agcccgttta tttcttgatt ccagttctta 601 agaagtctca gcattgtgtc tttttcatgt atcttacaag aagacagcat gtgcttctaa 661 cacctgatac attgtatcta ccagcacttg gtaaacagaa aagaaccaca tttttcttgt 721 aggagaaatt tggtgcctat ttcctaccag gcaccaataa gtgggaccaa taggtgggat 781 taaagataca gtagaaagta tttaaaactt gccagggggc aatagtctga aaataagtaa 841 attggtgcta tagaatggaa gttacaggct tctttctttt ttcccacaag atctgctcct 901 tgagccccta gagacttttc tgtctgttac tgtttcttca ttcctcatct gcagagccag EPI-109 917

961 ccctgagaag tgcagaccaa agccagggaa ggctctgcaa agatgtacaa atggaagtca 1021 ccttaataac ctctgactgc tgcgcataat acatttcact caaaagaggg gttaaacaat 1081 ggaacagaat acagaggcca gaaataatgc tgaacactga caaccatctg atctttgaca 1141 aaatccacaa aaacaagcaa tggagaaagg actccctatt ccataatggt gctgggataa 1201 ctgtctagct atatacagaa gattgaacct gggccccttc cttacatcat atacaaaaaa 1261 taactcaaga tggagtaaag acttaaatct aaaaccaaac actataaaaa ccctggaaga 1321 tagcctggga aataccattc tggacatagg acctggcaaa gacttcatga caagacacca 1381 aaagcaatag caacaaaaac caaattgact aatgaaacta atgaaactct ttagttgtac 1441 aacagatagt ttatctgtac aacaaaataa actatcaaca gagtaaacaa cctacagaat 1501 ggaaaaattt tttgcaaact atgcatctga caaaggtcta atatccagaa tctataagga 1561 atttaaacaa atttacaagc aaaaaaatga cctcattaaa aagtgggcaa aggacatgaa 1621 cagatgcttt tcaaaataag acattcacac atccaacaac catatgaaaa gatgtttaac 1681 atcactaatc attagaggaa tacaaatcaa aagcataata agataccatc taataccagt 1741 aggaatgact actattaaaa agtcagacaa taacagatgc tggtgaaggt tgtggagaaa 1801 agggaatgtt tatgcactgc tagtgggaat gtaaactagt tcagccattg tggaagagag 1861 tgtggtgatt cctcaaagaa tgtaaaaccg aactgccttt caatccagca atcccattat 1921 tggatataca ccaaaaggaa tagaaattgt tttaccgtaa aggcgcatgc atgcatatgt 1981 tcattacagc actatttacg atagcaaaga catggaatcg tctaaatgcc catcagtggt 2041 agactagcta aaaaaaaaaa aatgtggtac atatacatca cagaatagta tgcagccata 2101 aaaatgaaca agatcatcat gtcctttgca gcaacatgga tgtagttgga ggccattatc 2161 ctaagcaaat taatgcagga acagaaagcc aaataccaca tgttctcatt tataagtgac 2221 agctaaatat tgagtacaca tggacacaaa gaagggaaca atagacatgg gacctacttg 2281 agaatagagg gtgggaggag ggtgaggatc aaaaagtacc cataggacac tgtgcttatt 2341 acctgggtga tgaaataatt tgcacaccaa acccctgtga cacacaattt acctatatag 2401 aaaacctgtg catgtacccc tgaacctaaa agttaatggt gggggggtgg ggttaagcta 2461 ctttgtggta taaatctgag cattcatatt aaaataaaat atttacctca ttagagtaat 2521 taacatttat taagcaaaga gccaagtacc ttacacacat gatgtttaat ctcacaatga 2581 tctttaatct cataacaacc gtccattgta tgtacatatg tggaaattga gccttggaga 2641 gattaaatgc atggggcatg ccatttgact agaaactgga agcatcagga tttaaactca 2701 gttctgaatg gttttgtagg ctttgttttt tccacattat agcatggcct gccatgaaga 2761 acaggtcctt tctggtgttt gtcttgtttg gtttaagtga agcaaatatt tatttaaata 2821 ttcaagatat gctgttaaat ttttactcaa aaatttgagt acagtatgga tcttctgaag 2881 ccaaataact cttattcaat gcttagttga gaaattttat ggagtagttc tcaattttta 2941 tgtagttcca ctgcaaaggt aagtcttatg gaaagattca ctgtaatttt ttttcctcat 3001 ttggacatca gctttttctt ttcctcagac ccgctgaaag ataattttta aaataaaaac 3061 cttgttttta tatcaagtgg ggacattttt tccaaatgaa aaccgtgtat tcattttata 3121 tgataaaatc aatgttatta tttttaaaat tttgatttaa aaatcattaa aaataaattt 3181 tcagatatta cctgaaattc taccatccag agataatagt gcttaaagat ttgatatata 3241 gacacacaca catatataca tatatatcat cctaaacttc tttgtataaa tgtatataaa 3301 gtttttaata aaaactagga gattaatgcc ctttgaatga aaataaatac aatgtgtatg 3361 ctttaacatc ttgcctttac tttataacat ttatcacagc agtcatgaga taatgattta 3421 catggtcatt gttagtaagc taatagctaa gtgcatgaac tctggagcta gcctccctgg 3481 attttaatcc cagatctgtc actgaccagc tgagcaatac taggtaaatt gctcttgttc 3541 cttagtttct tcatctgtaa aatagagata aaaataatat ccacctcata ggattggtgt 3601 gagcattaaa tgagcatacg tatgtaggcc acttaacaac aatgccttca catactgaac 3661 acaaatatac gagctgttgt cttattgggc tcatgttttt cctaccacta agccgcatgc 3721 atgcaaggac catgttggtt ttgttccaca ttgcatcccc aacctggtat acagtgtgca 3781 ttcaatagtt gttgactatt attactagtg gcatttaaca aatatctgtt aaatgagtga 3841 agaaataccc atttactgca agtgtgtcta atattgatgg cataatgggg gaaactcaaa 3901 ctctggagtc aaacaggttt taaaacctta ttccctcatc ctcagttatt gacgtttttt 3961 ttttggcagg tgtgtgtgtg ggacaactta ttgaactttt ctgaatttcc agcttcgcat 4021 atataaaata gagatagtga ttcattcttg caatgtatgg atttgagaca attgtgtaag 4081 tttatcaata aatagtagct atttttgtat aagtattaca tataatatcc aggccactgc 4141 tttgcataac ccaaaagggg caccattcat gcagaataca acataaatgg tgtccctgga 4201 gcagtgcagt ataggaaccc tgaggggacc tacagtatac tttatagttc atagattaca 4261 aattatccct ttatcagagt ctctcaaggt tggatgtatt tgaggtccat aagagcaatt 4321 taggattaac agtagctgca gaaaccatct gcagtgatat tctcatttta aatccgcggg 4381 aaagaagaca gctataaact tgggacctgg gtttaagcat tttaaatgcc aagttcacca 4441 ttttctaaaa cacaacaaat acccagtgag agagggagaa gggaagtaaa tgcctctgaa 4501 taagcaagtt aatgtcagta gttgtactgt atgcatattg atgaacaata gaggaaccaa 4561 tgtccaatca gatgagcagg atatttggca ataacaagtt gcctttgagg aaaaatgatt 4621 ttcttggcaa gttctttatc agcattacaa agctaaaagc tacgcttatc atcacttata 4681 ctagcatacc ctgttgtgca aatgctgtct gtgtttgcat ctgctattgt tgatgcctgg 4741 tgcatgaatc aggactccag cccacaagtt ttcccagaac tttcttatgg ccatcatctt 4801. taagtgtctg gtgaacagtc atagtttggt acacaaaagg gtcaacctgg gggatggcta 4861 gggtttgact cagtcgttac atttcaatag agcaggaagg ggaaatggtg gcctgtaacc 4921 tcagggaatt ttgccagttg gtccacccca ctctctctct cctgctctga ggaagtggca 4981 cagcctagaa cagcaccaca ggtgagagaa atgcaaaccc taaccagaga agcagactct 5041 ttgccagtag taatagttca ggaccaccac cagcttttat taaaattttt aataacactc 5101 aagtattggc agaaagaaat aatcttgggt taactataac tagaatattg actcttcctc 5161 tgtggaagaa tcagccaatc acatttgttt acatcagttc ccctgaagaa gaaaaataca 5221 ctgatgttgc agcaagacaa atttaagcta gatgtaaata acttccttta gcctgtaatg 5281 ctaggctaat tacatattgg aactattttt tcagggaaga attgtgtagg gtttcaggga 5341 agaattctga agaaaatata gagctgaaat gatcttgcag ctcactgaaa ctgcagggtt 5401 tagatccaca ctgatactcg ttctattatc actgtaatga aggctgatgg aataagtaaa EPI-109 918

5461 aatgttttgt attagtatgt ttttacactt atttgcaagg cataaatagg ttaggttttg 5521 atcttaattt aattctaaca tgtattgtgc acaagctgtg agcagttttc aggagttagg 5581 tatctggcca tgactgattt ttcaggagtt aatcatctgg tagaagggtc atacacaata 5641 ggaagatgtg tgtgacaggt tgtgatcatt actataatca cacagagagc tgtagaattt 5701 taggctggca gggtggctca cgcctgtaat cccagcactt tgggaggcca aggcaggcgg 5761 atcaagaggt caggagatgg agaccatcct ggctaacacg gtgaaacccc gtctgtacta 5821 aaaatacaaa aaaaaaaaaa agccaggcgt ggtggtgggc gcctgtagtc ccagctactt 5881 gggaggctga ggcaggagaa tggcgtgaac ccgggaggtg gagcttgcag tgagccgaga 5941 tcgcatcact gcaatccaac ctgggcgaca gagggagact cagtctcaaa aaaaaaaaaa 6001 aaaaaaagtc atgttagatc cagaggggta gcaactgggg ctgggctgtc agtcaactca 6061 gtcaactcag tcaactctgc tcccccacag gagatgccag tgatgcattt tcatggccaa 6121 cattgtcagt cagcatcatt gaattactcc tgattataga gacacagctg caaacgattc 6181 cccattaaat atgatgtttc ttgcaatgtt tggaaggtac tcctttttag taagggaaat 6241 cccctcttct ggcttgctga aagttttttc tttccatttt aaaaatcgtg aattcctttt 6301 tgcaatattg aggtggttat atggtttctc ttctctaatc tgttaatatg gtgatttaat 6361 ggttagaaat tttctaatgt aaattccact catattgcag aaataaacct aaactgagca 6421 tgaggctata ttttttattt gcttctatat ttggttgcta tacagtatta tgtttaagat 6481 ttgttcacat atatttgtga atgggattgg actatttttc cttcttgccg atttttatct 6541 ggtttttaaa ttaaggatat tttagactta tgaaatattt ggcaaacaat ccttggcaag 6601 taattttttg gggaatttgt tttggctatt ttgagtatta cccaatatat tttaattaag 6661 ttattcttaa tgttttctta attaaaaaaa ttacctactc tagagatatt ctttatgtac 6721 tccagatttt gtctatttat accacttttc ttttttcctc gatgagtgtc atagatgttc 6781 atctattttt ttatcttctt tgatcttctc ttattccttg tttctattaa cttctgaagt 6841 ttattatttt cttttttcca cttccttatg gtttattctt tcaatttttc tctaacttct 6901 taagttgggt gtttaatttt tagcttgctt tgctttttta ggataagcat taaaactaca 6961 aattttcctt gttattcttt tgctgcaccc caaattgttg atatttctat tgtctaattt 7021 ctattcaatt agaatacttt aaagtttctt tttggttttt aaaaactaac tttttaaatt 7081 gacaaataaa aattgtgtat atttattgtg cacagcatat ggctttgaaa tatatgtaca 7141 ttgtggaatg gctaaattta gcttattaat gtatgcatta tctcacatac ttatcatttt 7201 ttgtggtgag agctatgtga cttttgaact tatgagttat ttaaatattt ttaaattatt 7261 aagcatattg ggattttaag taatttacct ttttattatt aacttataac aagtagaaca 7321 gttaacctgt atgattctac atcattgaaa tttattgaca tttgcttcat agtctattat 7381 atggtctact tttgttcatg ttacatctgt agtagaattg gctaatagtt gagtaaagta 7441 cacatatgtc tatgaaatca agtgtaatcc agagaaaaag agaaatttac tgaatatatt 7501 gttctaggtg ctattatatg ttgtcatgtt taatcctcac cacaattgta tgaggcagcc 7561 ataattaatt ccactttaca catgaggagc ctgagggtta aaaaaaaagc tagctctact 7621 atttgtaaag aatgaagcaa agatacaaat gaaggcccac atatcctata actagatatt 7681 taagcatttt aattcaagct ttaaaactgc taaataaaat gtgctccaat ttctatattg 7741 acagacatac cttcctaatg agctggggtt cgaatttaga aatctttgat gcttcagagt 7801 ccacactgaa atgtggaggc acatagtgag ttggtcccca gccttcagtc cacccacctt 7861 ctctttacta aatcaccttt cacatacatg tatgaacacc ccagcctcca agtccaaacc 7921 ctaaacaaaa tgggacaccc ttgtgcatac acagagacac agcccatcct caggaaaacc 7981 tggaaaagtc catacaagtt ctggaagcaa gcttgggacg gtttcagtag tgtggtctat 8041 aagggaggcc tcagaagaca ggttttctta attctgtgaa cttctcccac agtagaaagg 8101 gtgctggagg agggtcagag tgaggacttc taaagcatgg gtcctgagta ggggccactc 8161 ttgcccaagt ctaagaaggg tactagaata gcacactact actagatact agaacccaga 8221 tacaagcaca ggtcttctga aattaataat aataataact attaccatta ttataccagt 8281 agctgtcatt tatttagtgc ttattatttg ccagtcactg ttctaaattc tttacatgta 8341 ttatacaact gccatataac tgccatatga gggatgtacc ctcattgtca ccattttacc 8401 gatgagaaaa ctggcataaa acgtttaagt aacttgtcca agttacagag cttagtgaag 8461 ccacaatgtt gctcaatttg ctctcaaact tcaaagggat gggaaggaca cctaagtcat 8521 agagtcttta agaatcagag ctagaaggaa tcttagatgt tatctagtca gcctcctccc 8581 attacagtcc aagagaagat ggccctgagt tacttgtagc tatttttgca tgtgaattgc 8641 aagtgaatat acattctact gaagataaaa gatatttaaa gatatcgctg gatataggaa 8701 cagtggtttt aaatctctag gctttaactt ttctcagaac aagaaatcct ttttggtttt 8761 aatctatatg cacatctgta tttttctcaa ttatcgggta gtaaaatata acttttcttc 8821 tgtaatattt tttaacttta atgagtgttc ctcataatag aaaagtttgg aaaccattgc 8881 tatgggtata tactttctaa agggatagta atttctctag aatattcatt taatgctcca 8941 gaagtaatta gcacaattgt gcaagtctgt gcatcatcaa ctatacattc tgcctgttta 9001 ctccaaatcc acatgaaact gattatacag tcaaaggcga gcccagtgga gaggcatttt 9061 tggagacttc ctggtacat.t gagacagggt cggccagtct gcgttagggt cttggtcaaa 9121 actgcatttc tgaaactaaa ctcagattgc tttcttttaa ggggtcagaa ctgattcaaa 9181 tctacatttt taaaagcctt agatgtgggg cttttcctat tcccagtctc cgctattggt 9241 ctttgtgaat ccacaggcaa tttggccaca tccttgactc tctcttatat taagaattaa 9301 acagctaagt tcatgcagag gaaatataac aaaggaggga ctttcctaca agatctttga 9361 aaaatggaac atttgcataa gtcatattta gccagaactg ttgttttata ttttcctttc 9421 tgaatacttt gttacacctc ctcccagcca accccccccc tccctgaccc caactagtca 9481 gagaccaaag ccttcacaat ggtttacact tgaaccttcc tggccccacc ctcatcatca 9541 cgcctgaata attacattca ctgactggtc tcccctgctt ccgtttatct ccactcctaa 9601 accctctgac accttaatct tcccagaata ccattgtgat cctgttccac tcttgctcaa 9661 gttttcccag aaactagagt acaaacttta taagctttag agttgaaagc cactctatct 9721 ctttttcatc cccaggtctc tgccaaggca gtataacctg tccaacatct ctaacttcaa 9781 tacctttgtc ttagatacta gactctcctc ctggtttcta attaaacctg atctaggatc 9841 taattttgcc tctgaattct gttgcccttt gccaagtgat ctcttcctcc tctgagccgc 9901 agcatctctg agcttgcaca cttagcatag ccatagcaca cacagcctta gcttgcagtt EPI-109 919

9961 cagggtgttt accttccctc cccttccaga tgctggatcc ccagggatag gaactctgcc 10021 cttatgtgtc catagcccct ggtagtatgt cttgcagtcg tacattttca gcaaatgttt 10081 aattggttaa ttgaagacaa ctgtcccatg ccttaagcct ctctttttgc taaacatgcc 10141 tgtgtccttt gtcattgaac aactattttg atctattttc ttcctgacat aggggtcagt 10201 tccgaggatg ctgaaatcaa gagacatagc ttattctctc aaaattgctt tcaagagtga 10261 ttttgttgtg aattgagaac tggctgccta cttttggact acccacttca gcaagagtgt 10321 ttgaaaccaa atctattcta agtaattttt tattcccttt tctctatggc attagacaca 10381 cagctctttt aaactacctt tcgttatcta ttaaacagac attcagtaac tctatagaca 10441 ctgtctagct atatgaactt agacaaacta atatctctga gcttcagttt cttaaaattt 10501 aaaatgagga caataccatc tatggccggg gattaaatgc tatgaggaat gtaaaccaga 10561 tgtcaggtac catctctcta aaatccagat aaaatgaatt aaaaatactg gccgcaaacc 10621 ctctctaaga gttctcaaaa ttctcagaga gcttaatttt catgctcacc atagcaccga 10681 ttttcttcta aatattttgt ttctaccaaa atattttgtc ccaattttgc cttttatggc 10741 tatttcttca tatccacttt cccaaactaa agaagcagcc ccttcacctt aaactcctcc 10801 ttcaaagcaa cctaaataca ggtctgggtt tgtattccta gtgggatgtt acagaggtta 10861 gtgtgatgca gaggaggagt catgctgttt aaatccatac tagtccccag aggccaggct 10921 gcttctgcca cccctacccc tcccgccaca gagctcttca gcttctcaca tttctagttc 10981 ttctctctct actttcatta ccttctctct tttttttttt cttctcatgt gctcacggga 11041 gcagagaaaa ttaactcctc taagttttct taacacagag tgccttaatt acatattact 11101 attgtttgag ttcctgccaa cactacgtct gtagggtcac acctgctata ttagaggctt 11161 atcaaaaaaa gatagctttc tcctaaaaag ggatttggat gcctactaag ataactggat 11221 gccaagataa gtttaaccta acaaacttta ttattattat tattattatt attagagata 11281 ggtacttatt ctgtcaccca gactgcagtg cagggatgca ataatagctc actgcagcct 11341 caaagtcctg agttcatgca atccttctgc ttcagctccc tgagtagcta ggactacagg 11401 catatgctac tctgcccagc tacttttaaa aaaataatta gggatggggt cttgttgtat 11461 tgcccaggct cgtctcaaac ttctggtttc aagcaatcct cctgcctttt acctccctaa 11521 ttgttggagt tacaggcatg agccacagca ctcaaccaag atttaaaaac ttttaaaaga 11581 aatcacatta cttactgtta tcatcattat ggttactacc agtgttaaaa caattggtat 11641 tgaaaacacc actaccagat caagcttcaa accaagatgt caagtaaata ttattgtcag 11701 acctctgagc ccaagcctgc aggtatacac ccagatggcc tgaagcaagt gaagaatcac 11761 aaaagaactg aaaatggccg gttcctgcct taactgatga cattccacca ttgtgatttg 11821 ttcctgcccc accttgactg agggattaac cttgtgaaat tccttcccct ggctcagaag 11881 ctccccgact gagtaccttg tgacccccac ccctgcccac aagtgaaaaa ccccctttga 11941 ctgtaatttt ccactaccca cccaaatcct ataaaacagc ctcaccccta tctcccttcg 12001 ctgactctct tttcagactc aacctgcctg cacctaggtg attcaaaagc tttattgctc 12061 acacaaagcc tgtttggtgg tctcttcaca cagaccatgt gacatttggt gccgtaactc 12121 agatcgggga acctcccttg ggagatcagt cccctgtcat cctgctcttt gctccatgag 12181 aaagatccac ctatgacctc tggtcctcag accaaccagc ccaaggaaca tctcaccaat 12241 tttaaattgg gtaagtggcc tctttttact ctcttctcca gcctctctca ctatccctca 12301 acatctttct cctttcaatc ttggcaccac gcttcaatct ctcccttccc ttaatttcag 12361 ttcctttctt tttctggtag agacagagga aacgtgttct atctgtgaac ccaaaactcc 12421 agcactggtc atggacttgg aaagacagtc ttcccttgat gtttaatcac tgcagggatg 12481 cctgcctgat tattcaccca catttcagag ctgtctgatc actgcaggga cgcctgcctg 12541 gatccttcac cttagtggca agtaccactt tgcctgggtg gcaagcacca cctctcctgg 12601 ggggcaagca ccacctctcc tggggggcaa gtacccccca accccttctc tccatgtctc 12661 caccctctct tctctgggct tgcctccttc actatgggcc accttccacc ctccattcct 12721 cccttttctc ccttagcctg tgttctcaag aacttaaaac ctcttcaact cacgtctgac 12781 ctaaaaccta aatgccttac tttcttctgc aataccgctt gaccccaata caaactcaac 12841 aatggttcca aatagcctga aaacggcact ttcaatttct ccatcccaca agatctaaat 12901 aattcttgtc gtaaaatgga caaatggtct gaggtgcctg acatctgggc attcttttac 12961 acgtcggtcc ctccctagtc tctgttccca atgcaactca tcccaaatcc t cttctttc 13021 cctcctgcct gtcccctcag tcccaacccc aagtgtcgct gagtctttcc aatcttcctt 13081 ttctactgac ccatctgacc tctcccctct tccccagact gctcctcctc aggtcgctcc 13141 ccgccaggct gaatcaggct ccaattcttc ctcagcgtcc gctcctccac cctataatcc 13201 ttctatcacc tcccctcctc acacctggtc cagcttacag tttcattctg tgactagccc 13261 tcccccacct gcccaacaat ttcctcttaa agaggtggct ggagctaaag gcatagtcaa 13321 ggttaatgct cctttttctt tatccaacct ctcccatctc agttagtatt taggcttttt 13381 ttcatcaaat atgaatacct agcccactcc atggctcatt tggcagcaac tcctagacat 13441 tttacagcct tggacccaga ggggccagaa ggtcatctta ttctcaatat gcattttatt 13501 acccaatcca ctcccaacat tagaaaaagc tccaaaagtt agactccggc cctcaaaccc 13561 cacaacagga cttaattaac cttgccttca aagcgtacaa taatagagta gaggcagcca 13621 agtagcaaca tatttctgag ttgcaattcc ttgcctccac tgtgagagaa accccagcca 13681 catctccagt acacaagaac ttcaaaatgc ctaagccaca gtggtcaagc attcctacag 13741 gacctcctcc atcaggatct tgcttcaagt gccagaaatc tggccactgg gccaaggaat 13801 gccctcagcc tgggattcct cctaagccat gttccatctg tgtgggaccc cactggaaat 13861 cggactgtcc aacttgccca gcacccactc ccagagcccc tggaactctg gcccaaggct 13921 ctctgactga ctccttccca gatcttcttg gcttagtggc tgaagactga tgctgcctga 13981 tcgcctcaga agcctcctgg accatcacag atgcttttgg taactcttac agtggagggt 14041 aagtccgtcc ccttcttaa.t caatgcagag gctacccact ccacattacc ttctcttcaa 14101 ggtcctgttt cccttgtctt cataaatgtt gtgggtattg atggccaggc ttctaaaccc 14161 cttaaaactc cccaactctg gtgccgattt aaacaacatt cttttataca cttcttttta 14221 gttatcccca cctgcccagt tcccttatta ggctgagaca ttttaaccaa attatttgct 14281 tccctgacta ttcctggact acagccacat ctcattgctg cccttcttcc caacccaaaa 14341 gtggcaactc ctttgccact tcctctcata tccccctacc ttaacccaca ggtatgggac 14401 acctctactc cctccctggc aacaaatcac accctcatta ctatcccatt aaaacctaat EPI-109 920

14461 cacccttacc tgggtcaacg ccagtatccc atcccacaac aggctttaaa gggattaaag

14521 cctgttatca cttgcctgtt acaacatgtc cttttaaagc ctgtaaactc tccttacaat

14581 tcccccattt tacctgtcca aaaactggac atgccttaca ggttagttca ggatctgtgc

14641 cttatcaacc aaattgtctt gcctatccac gccatggtgc caaacccata tactctccta

14701 tcctcaatac ctccctccaa aacccctcca taacccttat tctgttctgg atctcaaaac

14761 atgctttctt tactattcat ttgcaccctt catcccagcc tctcttcact ttcacttgga

14821 ctgaccctga cacccatcag cctcagcaac ttacctgggc tgtactgccg caaggcttca

14881 tggacagccc ccattacctc agtcaaccca aatttcttct tcatccatta cctatccagg

14941 catagttctt catgaaaaca cacgtgctct ccctgctgat catgtccagc taatctcccc

15001 aaccccagga ctggcaaatt gactttactc acatgcccca aatcaggaca ctaaagtacc

15061 tcttggtctg ggtagacact ttcactggat aggtagatgc ctttcccaca gggcctaaga

15121 aggccaccgt ggtcatttct tcccttctgt cagacataat tccttggttt ggccttccca

15181 cctctataca gtctgataat ggacaagcct ttactagtca aagcacgcaa gcagtttctc

15241 aggctcttgg tattcagtga aaccttcata ccccttaccg tcctcaatcc ttaggaaagg

15301 tagaactgat taatggtctt ttaaaaacac acctcaccaa gctcagcctc caacttaaaa

15361 aggactggac agtactttta ccacttgcca ttctcagaat tcgggcctgt cctcgaaatg

15421 ctacaaggta cagcccattt aagattctgt atggacgctc ctttttatta ggccccagtc

15481 tcattccaga caccagccca acttgaactg tgccccaaaa acttgtcatc cctacaatct

15541 tctgtctagt catactccta ttcaccattc tcaactactt gtaaatgccc tgcccttttt

15601 tacagtgctg atttatactt ttcctccaaa ccatcataac tgatatctcc tggttttacc

15661 tcaaaccgcc acccttaagt ctctcttaaa gtggatagaa gatcttcagt gacaaggtac

15721 actccaatac tttcacccta ataaagccct attctttact tttatattca ctcttattct

15781 tgttcccatt cttatgccac tctctacctc tccccagcta tctccaccac actatcaatc

15841 tcactcactc tctcctagcc atttctaatc cttctttaac aaacaattgc tggctttaca

15901 atttctcttt cctccaaaat caccgagtcc tcaatttact cactgctaaa aaaggggact

15961 ctgcatattt ttaaatgaag agtgttgttt ttacctaaat caatctggcc tggtatatga

16021 caacataaaa aaaactcaag gatagagcca aaaaccttgc caaccaagca agtaattatg

16081 ctgaaccccc ttgggcactc taattagatg tcctgggttc tcccgattct taatccttta

16141 atacctgttt ttctccttct cttatgcaga ccttgtgtct tccatttagt ttctcaattc

16201 atacaaaacc gtatccaggc catcaccaat cattctatac gacaaatgtt ttaagggagg

16261 agaccacccc tcatattgtc ttatgcccaa tttctgcctc caaagaaaga agtaaaaatg

16321 aaaaggcaga aatgaaatcc acaggcagac agcctgatgc cacaccctgg gcctggtggt

16381 taagatcaac ccctgaccta atcagttatg ttatctatag attacagaca ttgtatggaa

16441 aagcactgtg aaaatccctg tcttgttctg ttcctctaat taccagtaca cgcagcccct

16501 agtcatgtac cccctgcttg ctccccctgc ttgctcaatc agtcatgacc ctctcacgca

16561 gaccccctta gagttgtaag cccttaagag gaaaaggaat tgttcactcg gagagctcgg

16621 tttttgagac atgagtcttg ccaatgctcc cagctgaata aagcccttcc ttctttaact

16681 cagtgtctga ggggttttgt ctgtgtcttg tcctgctaca gtttcatcta acaaccccat

16741 aatatcaccc cttaccacaa aatcttcctt cagcttaatc tctcccactc taggttctca

16801 cgccacccct aatcctgctc gaagcagccc tgagaaacat cgcccgttat ctctccacac

16861 cacccccaaa aattttcact gccccaacac tttaccacta tttcgtttta tttttcttat

16921 taatataaga agatagaaat gtcaggcctc tgagcccaag cctgcacgta tacatccaca

16981 tggcctgaag caagtgaaga atcacaaaag aagtgaaaat ggctggttcc tgccttaact

17041 gatgatattc caccattgtg atttgttcct gcgccacctt gactgaggga ttaaccttgt

17101 gaaattcctt cccctggctc agaagctccc ccactgagca ccttgtgacc cccaccccta

17161 cccacaagtg aaaaaccccc tttgactgta attttccact acccacccaa atcctataaa

17221 acagccccac cccatctccc tttgctgact ctatttttgg actcagccca cctgcaccca

17281 ggtgattcaa aagcttcatt gctcacacaa agcctgtttg gtggtctctt cacaccgaca

17341 cgcgtgataa ttattatatt acttttaact aaaacccttt cagagtctcg cagggaaggc

17401 tgtatatatc tcataaaatg ttggggccca ctggatcaga caaggccaca aaggccaaag

17461 ggaagtaaag atctcattat ttctcctaat aatttccctg tcctttgtca taaatggtgg

17521 gtaggctgtt atggtgatgg cagattttct ttccataaaa tgtccataat aggacatttg

17581 aacagaaggg aaaaatcaaa ttgctgaagt tgaaagaggg caatgcaaag aactttggag

17641 aaagaactgt acagagaagt caactggcag atgggaggaa gtttaagggg aaaaatatag

17701 atgtctaaag aatacattta ttcattttcc acagtgcaat ttggacaaga agcctctttc

17761 ttgcttcttt ctattctcat taaatcatta gagctcaagc aatccttctg cctcagcttc

17821 ccgactagct aggactacag gtatgtgcta ctatgcccag ctaatttttt aaaaattaga

17881 ttttaatttg gtgaactatt tctgtaggaa actacaataa tacagcccag gcacattgat

17941 cttgggtgaa caaatcagaa ggaatgaata attctgtgtt cctgggactc tgacaatttc

18001 atgaacttgg tactctgagt aaagcatagg aggagttatt tcataaaatg tggagcacaa

18061 tcatgtgaca aagataatgg gatccccatt tcataaataa atctgaagtt cagagagagt

18121 aacaactggc cagggtcaca tcacggagac agaggcaggg ttcccactga tgcctctgac

18181 tccctgtccc aggcccttcc tcctcccgca agcagaagtg cagggggcag agctgaccct

18241 gtgcagtgaa aatctgaggg ctgagttcct attggaacac aagtgaaaga cttcctggct

18301 tctaatctca ggataaggac tcagagctcc atctgttcca gccttaggat aagaaccaga

18361 atcttacacc atgaaagcat gaaaggtaag atttgagtga ggaaaaaaaa aaaaaaagtc

18421 tgtgtttcag attcagttca caaagcagtt tcatacttaa ggtaccatca caataaccct

18481 gtggggtaag caaggcaaat ttcattcttg ttttatgggc ataggaagta agtctcaggg

18541 aggttaagac caaggtttct ggagaatttt atattatgaa tcttgattta tgggattact

18601 attatgtaat tcctaagatc atataggaat cctagagctt gaatatagaa ctttattttt

18661 aaatctatat acatcataat tacaaggagt agtgtccatt tgggttcctt ggccctgatg

18721 tgttagtgga ataaacattt ttgtcagggt tgccatgtgt gtctgtgcac gtgtgcactg

18781 tacacctcca ggggatgtac cctaaaccac atgaatgtga tttgcacatc caagatttac

18841 agtgtactat agggagaatc ttttgcaaca gcttttgcta taatacagaa tctgagatgt

18901 ctttgagaaa gaaaagtgta atcattacca aaaaattatt ctcataatgt gtgcaaattt EPI-109 921

18961 gtatgaaatc tatattggcc atgggacaag gaggtatttc cagctagctt ctgaaagggc

19021 tctattctct cataagaatt cagctgttga cattaggtga tatctgccca ggtcatcaga

19081 tgccatagag aaagagggtt tgctgaaact tatatcagca gtgcactgta tgctctttct

19141 gatttatttg aacattcatt tattgagtgt caagtaatgc actagatact ccagggatct

19201 gacacaaact ctgccctgaa ggagcatgta atctcactgg ggagaaaaca aaacatatga

19261 taatttcaaa ataacaaact aggcaaacta gttaacactt aaaaagcagg ctttattcaa

19321 atgcaaaatt gcatgttaca gggtaacctt tcagtaagaa gccaggaaga ggagctcatc

19381 atgggttgga ttagtaaagg actagttata aaagaagtgg tggggttgag ggaggcctga

19441 gatgaaattt aaagaatatg tagaatctag gtaagtggat aaaaggtctg ggggcagggg

19501 aaaggagagc atttcattgt gaatcaagga atttctccac ctgttttaac tcttccatat

19561 gacatcaaag agatgtcact tgcagctagc atttcagtga tgttttctta ctaataatat

19621 cgtgataaaa gaaacattga ctataagaaa taggaatggg tctcataaaa ggaaacagca

19681 aaacccccaa actaaaaaac agcgcaggct atttctctct tctctccttt tgcttggcac

19741 tcatgagatg ctaggtgtgg aagtcagcca actgaaaaag agaggtggct gaagaaggtg

19801 gggaggctga agccagttaa ataggatggt ccaattcaca gacggcgagg ctacagtgca

19861 aataggactc tttcaacttg agcaggaccc cattacttca ctggagttag aaagaaagga

19921 gagcgtagac tttttgaact ttctataaga gtgtacctcc acagtataca gaagacgacg

19981 tgaaatttga tctgcaagaa aactgagtcc atattcacat atgtatcaaa tttgcacttc

20041 atttagaagt gtctgtcatc aagtacagca ctgaattgaa actgaaaaca agagtcaaga

20101 aagagcaaag tcagccatct ttatattcca catgaatcct ttccctttat ggtcttattt

20161 gtttctcctc agaaaagaca aaaagctgag ctgtataaac acctgtgggc tgggggttga

20221 gggataaatg aggggcgaaa tggaagctga aggaactgtt ggtcaggtag aaatcttccc

20281 agatgcactg aaggaaacac acttcatgtt tgacgtagga ggtgccacca cacaaaacgt

20341 ttcatggaag gatttaaagg atctcatgat ttttagtatt ccaagaattt tctttcacca

20401 agggcgattt aatatgggtc attcatactg aaagaaaaac aaaagataat aagagtttaa

20461 aaattgcaaa acttggagtg ttagtagtaa aggtaaatat tcattagaga tgagaagagg

20521 agcaaggaaa tgctttcagc tggaaatctc agacaagagg ccaggcttta ggaacctctg

20581 aagatgaaca aatgtaagca aaccctagta gcagcacttc tcagattttc atgtgcttac

20641 cactcagaga tggtgttaaa atgcagactc tgattcagta ggtctgagtg gagcctgaga

20701 ttctgcaccc ctaacaagct ctttagtgat gcttatgcca ctggcgcaca gaccccactt

20761 ggagaaattt ttgtggtgca tacggtcttt gtctccagat ctaatgagtc tgaaggacag

20821 tgtagattga ttttttaaat ttatgtttat tttaatttaa tttaatttaa tttatttatt

20881 tatttatttt tgagatggag tctcactctg ttgcccagtc cggagtgcag tggcacggag

20941 gcagctcatg caaccacggc ctcctgggtt caagcgattc ttccgcctca acttcctgag

21001 tagctgggaa tacaggcacg tgccagcaca cccagctaat ttttgtattt ttagtagaga

21061 tggggtttca ccacattggc caagctaatc tcaaactcct gacctcatga tccacctgcc

21121 acggcctccg aaagtgctgg gattacaggc gtgagccacc gagcccagct gtagattgat

21181 tttgagcagt ggaaagtcaa ggaattagaa ggcatgctta aatggaaagt gaaattggag

21241 aaaatttaaa ctcatgaaat agtggtggtt ataaactcgt gataaattat atcctgggat

21301 ataatttaat gagatggtaa cacatttagt ttaaagaaat aagtgacact ttttttgtgt

21361 gacacaactg tcttattctt ggaaaggaca aggagagaat gaaatatggt atgtcttcac

21421 agcacctttc aaagggagaa ccagattctg aggagctggt ctcatgatga actgtcaggg

21481 taaaccacag ttcagcagct gcaaatgtgc ttgccaaaat agagacaaaa aaatgtttct

21541 gaaaacaaaa tttcacatat gccctcctct gaggttggca tcatatcttc ctgtgtatct

21601 tgggtgtagc ttctatcctg ccagaattta gacagtagaa accaaatgag gtgataaaca

21661 gagtcatttt gcagaagagt caaaataacc cagcaagaaa tgaaaccaca aatgcccaag

21721 gagtcattca ttcaccattc aaaagctaat agaaatgaac acaaactact atgaaaattc

21781 acccaagaac ttaaaaaaaa aaaaaaaggc tcatggtgtt tagtgtgata gtattcattt

21841 tacctttgac ttgttctaaa aacacaccat acttctaccc cacccttcct cagtgccgtc

21901 acacaatggt ttcagtgtga aaaaaaaaac cacgttactg gaaaaggagg gtgcctggga

21961 cttgccactc taagctggta gtcaagggtc ttgagttcta aaagcatacg cgttaagagc

22021 atgattcctg gatccaaatg agtatggatc tcagcattgc catttattgt gacctcaggc

22081 tattttattt ctctgtgcct gtttctttat cagtaatgaa gatgttcata gacccttctc

22141 ccacagactt aaaggcatat ttcatgattt aagacatgta aaccattcat aacagtatac

22201 aacatggaat taatatttga taaaggttta tgattattgt aactaactct gtcacttgct

22261 caaggcctat agaaaactta cttaattagt tcaactacaa aaagagtttg aatgtgatat

22321 ccaccaagat catattcaga cctagaattc tgtgattctt atgaattaat acagccttgg

22381 tcaataaatg agagctgggc aaataattct tctttgctag gcctttctag accatctggt

22441 gaagcattca agacttatgt tattggggcc agccttcctt tccaacttca actccacaac

22501 tcctcaataa gccatgggct caagaaagtt ctgctcagtg gcccctgaaa aatgctttca

22561 tagtctcact accataccac tgcttacaca atttccttcc tacagactgc cttcctttcc

22621 tgcttttctc catataccta aatcctatct attcttcata agcaaccttc tttataacat

22681 tttctataac caccaagcca aatgaccttt tccttcttaa atatagcacc cattggccat

22741 taccatgctc tgccttgtat ttttctgatt tttttctttc tatattcctg tcttaactcc

22801 ccagctaggt aataattttc ctgaaatcag ggaccaggct gactcctctt gctgtctcaa

22861 gaaagcttag cagtttccaa cacaaaaatg ttcaataaac aactattaat tgactgatta

22921 taaaaaatca gtgaaccatt aaacttaata tagcaatttg cttagcatgg taattagctt

22981 tttgctaata ttcttccagc cagtctctcc tcctgtgcct caaggacatc ttaaaaaaaa

23041 aaaatctagt tgatctgctt ccatctagtg gcaattaaaa caggtggttc cggtagccag

23101 aaaacagctc tgggtagatt gtgccagaaa atactttcac tcagtaggtg cgagtttgaa

23161 agaaatcttc acatctgtgg gtttcctgcc acagacatag ggagaccagc ccagagaaag

23221 aagcctttcc tcactagact ccatttgcac tagtaaagag aagacagagt aattaaaaag

23281 aataaaaaga acctccactg atcgtacatc ctcatccagt tacccctgcc ccacttctcc

23341 ttcacagcca aacattttaa aagagatgac tgcttgttct gtctctactt tctcatcctc

23401 agtaatgctc aatgcttggc cgtctgacct ctgtcttgat gtctgcactg caaatagtct EPI-109 922

23461 ccccactgac acccttgttg catccagggg atacttactg gttctcttgg caatgtttga 23521 aaccgttccc ctttctttgt ttccttggca ttcattaccc cacactcttt ctcctcttcc 23581 ttctccctgc ctggcaacat cttttcattt ctctttccct taggtgactt attagataat 23641 gatgttcctc tggctcccat actctctccc aggtcctctt ccattcttaa agcactcaca 23701 ccctccctgg atgatagtac ccactcctga gatggcagtt acctcctgaa atgtgaggga 23761 cccaaatcca cttctcctgc catagcctct gtgctttgga taggtccaat gagccacagt 23821 gaatgatgtg catacaccca aagctcagta caaaactgaa cccatgatct ttacctccaa 23881 aacctctcat tcttttatgt tcccttctca gaagtaaaca ggactaccat ccgccagttt 23941 ccaggtgaga aagatgataa tttgattctt ctctctcact tttagccaat taacagacac 24001 attcagttaa tatcacctcc tcttatttca tgaacccatt cttactacta gttccctaga 24061 caggcgccat cggttttaat ctaataactg caaatgcctc caaaacaagt ctctttgaat 24121 ccaggctcac ctgtctccca cacttgccat actgctctgc agggtgacct tataagatgc 24181 cagaggtaag gctactcact gtttaaaccc ctttagtgat atcccaaaag acctcaagat 24241 aaagcccata tcacatggct tatacattag tttatgatct ggcttctggt gcctcatttt 24301 tccccacttt ttcctttgca ttctaagcaa tggcccatac taagtttgtg attggtagga 24361 tggttgccca aaccagcatc caatcccttc agaaatcatc tcacttcatt tctagcattt 24421 taaaggaagc tcagttgtcc agctgggtac tgaatatgtc accaaagtcc tcctttcata 24481 gtttatttta cttaaactct ccttcctaaa attccagagc aagtcactaa accctagata 24541 ctgagaaata tttttccatc ttcatttctg ccaggtgggc catcaacttt cacatgtctg 24601 catctcctcc cactgtgcta tttctccagt agaagaaatt tgagcttcaa gaccaaactg 24661 aaaaatactt gcctccttgg ggaagctgta ggtagaattc atgctcccta tctttcccac 24721 atttctgaag gacaatgcct gttagagcaa ttgaatgcaa atagtcaatt gaataagcat 24781 ttattcattt ctcaataagt gcttgttcaa ttgaatattt cttaaataat atatttaaga 24841 acaagaagaa cacaccacaa tgtttttaac cctcagaaaa aattctgagg taatcagaaa 24901 aatctccctt tacataaact gcccttttct aatagggatt acttgttcgt tcattcattc 24961 attcagctcc actagcacca aaaagcacag ctctgaaagg aagctagtag atttatcacc 25021 ttatctggtc atttggatga ggaccccagg taaataaact actatggggt taatgtgtct 25081 agctagagca ggaagtaact taaggaagta gagaatgaat cagcagatgt ggaaactcct 25141 cgccactaat aaaacttacc ttctcttgga tttcttgcct gaaaatagaa aatagagaaa 25201 aggcattagc aaaaattaga caatttaaag tttttcaagt aagggagaag gaagactccc 25261 actctcaaaa ctgtcttttg aagtatatta ggtatttgtt aggtggaccc tatctgtgtc 25321 aaaggagatt tgaggaactg gcttaataaa cagtggtaga cactaataca gaacagacat 25381 gttgatgcag atgcctcctg aggttccatt ccattctccg tgctactcaa gaagacagaa 25441 ttgctaaatt gcctggtggc aagacccaat atgtccattc aagtgtttat cccttcccaa 25501 tctgccatct catcctacct gcagattctt cccttgaggg acagctgcta atactgtaaa 25561 actatgtgcc attacagctc acagcatcat ctctatgaga atccacaaga gaatttcact 25621 ttggtcttgt tggtaggaat tgtgcagcct catctgagta actaatgtgt ttttatctta 25681 caaacacaag gaatatcaca tggttctcct ttgactggct gtaaggaaac tcagagctag 25741 atctgagacc ctctcctacc aagtatataa aactttgtga catacatttt tgtgccataa 25801 cttcaacctt ggttccaaat gatttttgta ccctaagttt aaatttggct ttcttttttt 25861 tttttttgta ctcaataaaa catcaagctc atttattatt gcgaagagcg aaacaacaaa 25921 gcttccacag cgtggaaggg gacccgagtg ggttgcccaa attggcttct ttttcttact 25981 ttttaattaa ttttaatttg ctatactgaa cacattttgt actgttctca cattcttttt 26041 gaaaaaagca gaatataaat aagtagataa cttaaaaaaa actctttgag cagaaagaat 26101 catttgggag gcaatatatt tcagtggctg taaagtggca ttctagaatc atcctaccca 26161 ggtgaaagcc ctattttgcc acctgtagtg tagtgtgtat ttgaacagct actttctttt 26221 ctaaactaca atttcttcat ctgttaaaga ggcataataa ttgtatcatc ctcattgggt 26281 tgataaaata aaatatttcc aagtatttag ttcaggtcct agcacgtaga cagtgttgca 26341 ttactgtttt aatcctttaa agtattaaag actactattt gaaatctttt cttctaaaat 26401 tcagcctgct gatgaccaag tgcacttgag cagggggaat caaatctgaa ttaatttcag 26461 attctggtta gcttcacata aatatttttt ttagggatga tgaacctaac agcaatagat 26521 gagtaagaat ctgttcctac tgagagagtt tcattttgaa gaaaaaggaa ctaagggggc 26581 atgtgttcag tttcatgccc tggtctaacc ctgtgtgttg gttctggtgg gaaattcttc 26641 caaccgagga aaaaaccagt tcacaaatct gaagaccagt gattttagaa gatgtatctg 26701 gactggagtc taatctctga ctctgggtcc tgctgatatg gtatttttga gatttggcct 26761 aaaacatcat tgccctggtt tccttattta ccaaacaggg ccaatggtag tgactaatca 26821 gaaaatgata atgcctggtg cacaaaatgt gtctagatga gcccatgcac aaggacacat 26881 gtttctggaa ctgttcctta ttcctttcct aaaagaaagg agggaaagtc tccatactaa 26941 gactactagg gcaggggaca aagtgctaga gtcagaagat tcatctgagg acagaagaat 27001 aggggtgaag gctctagtca cttcattggc taccatgctc taaatagtta cctgtgccct 27061 ttttctaact attagaaccc aaaaagccta taaattctct ctctctctct ctctctctct 27121 gtgtatatat atacatatac acacacacat agacacacac acacacctaa acacacacat 27181 agagatttat gactttttac ttttatcctt gtaaatgcca ttaactatat tttgtcttag 27241 atttagcctg ggaatgtagc cattatttct accattgcct ccataggaaa aatactcttc 27301 atgttttaaa ggaccaacct acaactaaaa tctttggaaa gcagaatcat ttgtaagttg 27361 gtgaaaatgg aagatgttgt tttataaatg aagacttttt tttttttttt ttttgagaca 27421 gggcctcact ctgttgtgga gtgcagtggt gctgtcatgg cttactgcag ccttgacctc 27481 ctgggttcaa gtgatcctcc cacctcagtc tcctgggtag ctgggactac atgtgcatgc 27541 taccatgcct gactaatttt ttgtattttt gtagagatgt ggtttcgcca tgttgcccag 27601 gctggtcttg aactcgtggg ctcaagtaat cctcctgcct cagcctccaa aagtgctggg 27661 attagaggtg acagccaagg tgcctggccc acagatgaag actatttaat gttatcttaa 27721 agatacccta agcttcctac caagccagtg atcttttggg gcttctgttt tctttgttgg 27781 cataactgta actagcctaa ctgcccgtta tctgtttcct gtttgcccca cactgattcc 27841 cacagcagtt ttcaagttat cggtttgaga tcttgtacag aaatgactcc aaggtaaaaa 27901 atttaaaaac aacccctcta atttttttac ccttgcttat aaaacagcct tagccagcta EPI-109 92₃

27961 acccctcact acatgcaaat gagtttgatt ctattctttt gattctacaa acacttatta 28021 aaagatttta gaattcggaa ataaatagct tccttattaa ggtgacttac agccccaaag 28081 tccttaaaat tatttagaca atagccacct tatcccaggg ggcagtgtgt aataacccac 28141 cctgttctct atccgtcagt tctgccatca tcgcccaagg taggaagaaa gacaggacaa 28201 ccggggtcaa gatttgaagt ctcaatggaa agaataatca gtggttggag aaaactgtca 28261 ttcttctttt gccttaatgc agtacttgat acttatactt agtactgtat agtacttagt 28321 actgtataat actataagat agtgagattc aatcagcaca gaatttctaa tagcaagggc 28381 agagacattt taactgctca gtgctctcag gttatacata gctaatgaag ttcttgcata 28441 tcaacaatcc ccacccccct cacacacttt gtctttctgg attggttaga aaacttacct 28501 agcgcccact attctcaaat ttaaatgaaa gataagatca gagtggcacg caattaggga 28561 ctgataaata atatttttgt aattgccagt gtaaatggac agggggcaac ctttacatac 28621 catattcagt gaacagaata cgtactaact aatttgatgg aaggaaaatt aaaatgacaa 28681 tcaactgagc ccacagaaag gcaacacaga gcagttggtt agcaattgtt tcgagatcat 28741 ccctgaactt gaaacaggta tatctttttt tttttttttt ttgagacaga gtctcactct 28801 gtcaccaggc tggagtgcaa tggtgcggtc tcagctcact gcaacctccg cctcccgggt 28861 tcaagtgatt cttctgtctc agcctcccga gtagctggga ttacaggtgc ccgccaccac 28921 gcctggctaa tttttgtatt tttagtagag acagggtttc accatgttgg ccaggctggt 28981 cttgaactgc tgagctcatg atccgcccgc ctcggcctcc caaagtgctg ggattacagg 29041 catgagccac cacacctggc caaaacaggt atatcttaaa agctgcccaa tgtccatgaa 29101 tgttacagcc ttgaatggtt cttccaggtg agtttggcca aatgtggcac catacaccca 29161 aggcctgctg caggctagtg ggttgctcac actttaaagc tgagacacac tcatgcctta 29221 aggtaaaggg agtgataatc tgggcagcag atgttaactt ctcaaggcag tcctccttct 29281 cttttcctct ccagtgacgg atggttggaa agcatatatg gtgcatttgg ttagagctgt 29341 ggccttggtg aatagatact tgggagaata catgggaatt tctcccaggg ttaatgcaat 29401 gcccatgtgt tgggaaccag gtgactcttg aagaggtcag gtatttggga gcagtgcctt 29461 gaaaccttag tggacattag acccacttcc tagtggaatt gtagcattga aatccaaggc 29521 atgtaggctc ttagaggaca gagatagtgt gtcatttttt cagaattaat taagagcagg 29581 ccaggcgtgg tggctcacac ctgtaatcca agccctttgg gaggccaagg caggcagatc 29641 acgaggtcag gagatcgaga ccactctggc taacacagtg aaaccccgtg tctactaaaa 29701 atacaaaaaa ttagctgggc atggtggcac gctcctgtag tcccagctac ttgggaggct 29761 gaggtgggag aatagcttga acccagaagg cggaggttgc agtgagctga aattgcacca 29821 ctgcactcta gcctggtgac agagtgaggc tctgtctcaa aaaaaaaaaa gtattaaaga 29881 attacataag agcaaagaac cattagaata tctcacttag ttgttatcag cctagcaagc 29941 tgccttgaag gtaatagaca tttttaaaag tttatcagat gaaaagcgaa aatcagccaa 30001 cctgttttaa tgaaggtgtg tcctgggctg atttacatgt ctccagggac tgatggctct 30061 agaatgtaaa gcttggcatc ctgcttgtgt tgaatctatc acatttaatt tcctgtgggt 30121 ttcttttttt tttctttttc actttaaagt tgtgttcttt tcatgtgaag ttaaactcac 30181 ataccttttt ttaatctcct tgccagccaa atgataaatg ccaacccaga gaatgcagta 30241 accatgactg ccactggaat gaagaggggg ttataatcac cctccttaat cattgagaaa 30301 cttttgtcca attctgaaag agaaatcagt aaggcacata gcatgagacc accagcatta 30361 tttccttagt ctatctcatg atatttgact tttttcctcc ttacatctcc cagtagtagc 30421 ccatttgatg ccatttgaca gatgaggaaa ctggcatggg aaggcccctg atgagtctac 30481 agcataggca aagactggac cagccttgct agtctaatgc ctacagaatc tcaatgccca 30541 gatttgtggt tcatagagtt cctgaaaatg cacctaaaaa tgttggcaag aatggtcatc 30601 gttgtattta gctccatgga cttgttcaat gactggaact ctgaaacaca gagaagagct 30661 aaaagcctaa tacaacttca ggaaaaataa aagccaatga tctgaactgg ataattcacc 30721 agtcaaagga aatcattaa^'t gcttttactt taaagcagtt gtgcaaaaat aagcacttga 30781 tttttacatg ccaaggacct gcactaattt ctttccaatg cagtagttac cacttccctc 30841 tacttccttc acgaataagt aaaagggcat gtttagagat actcttgtaa gtgtaaacta 30901 agttcatttg ggagcctcta tttgaaaata ctggtataaa aaaaaatctg tctcctgata 30961 ctaacatttg aaggaatcta cttttttaca tattggcaga gggtctgatt ctatccttag 31021 ttcttcccat tactttgatg aaccttttca aggtgatttg atccccacac ccaaatatat 31081 gattgagaga aggctcaagt tcccaggagc tccagacaga aggtacctgt tggcttgatg 31141 aagatgagga ggaaatgaac actagctagg ccttaaaggg aaatgtctct gataggccta 31201 atacacagtc ctctgctaaa ggcctccctg cctctctctg ctcatccact ctactccctg 31261 gccctgggca cgcagcacac agagatcagc atttctgaca gcttctgtag atcctaccat 31321 ttaaagactt ttgtcatcca tgcagatagt ctcaggagca gacacaggta gctattcttt 31381 cacatgctag cttaacatgc atttgcttta gcacctattg ccaggcactg tgtcaggtgg 31441 agggtataca aagatgaaca agacatgatt cttctcatat acagatagat tttggaggca 31501 ttagcttagt gatgattcag gagtatccat tatttgggga agtaggtggt cattagtgac 31561 cttttacagg catttcaatg ggctaacaga gatgttagat tgtagtggaa tagaagaatg 31621 ggtaaaaagt aaatcagtga gttcagattt taggagttaa gatggcaaga ggtgagaaca 31681 aaaaaaggaa atgattgtca ttaaaggagg aggaaagacc agccaaagat tttacagtga 31741 gttaagcata caaatttatt tctaggccac atattcttag caaaacaaca tgtaaatgtt 31801 tatgtatgtc tttcctcata tctgctcatc catcagctcc atcgttaaga tttcagtttt 31861 ccaggacaaa cttactcact ttgacatatt ggactaggat ttgaccagat tccagatgat 31921 tcacaaatgg ttttcttctt cccaattaac tcagttcctt ctgagcagat gaaggtacat 31981 gcagaggtaa agctgaagct ggccagggga tggctacagt tcatgatccc caaatctggt 32041 gctgatagag gctcacactg aatcacttca atgaaaaaga aaaaaaaaaa aaagacaaaa 32101 cagtatttct gagtagagac cctcccttga gcaaaggatt tttagccaaa gctgcctgac 32161 tacattactt gtgatattgc ttccaggctt tattttcttg agaatgatgg tgggtggtga 32221 atgagagatg aaggcaagga agcattgaaa gctgtgggga gaggagtagc tactccaggc 32281 tgctgcccta gctaaggtga ccctcccctt ctgctggaag taccatgcca tatggcctct 32341 gcatcaaggg ctcttatggg atattctcag agaatctctg ccgtttcatc tgttctgata 32401 tctacccaag cattttgaaa aacatcccaa ttcactgaag caagtccaac ttccgtaaat EPI-109 924

32461 tccagtaggt gggttgacag ttttataatt tcaataaggg attttgatag cacttctaag 32521 aattaaacta cttaaactaa tgcatcagga gcatacttgt agaaaagtta accaaaactt 32581 cgtaagttca gatgacattg gttttctccc atatggagat aaggttggca gttaaaaatg 32641 aaaaaaaaaa aaaaacctac cttatttcaa acttgaaaag atcaagagat tgtgtttttg 32701 tttttcagtt gttattctcc taaaagttta tgcatgagga aaagtaaaag tgattttaag 32761 aataagccaa ataaaacaac caagaaagac ctccactacc ctgggaagga aactggttgg 32821 tattaagtag gacaccacat aaaacaggtg ttattgagag gagaagaacc aaaatgtaac 32881 tgaggttcaa caagacatta tttatgcaat ggcaatgaga aaaataaaaa acacagtata 32941 accatgctgt attgctataa gtcatgttac acactgggag atggcttcag gggtatttgg 33001 tttttacttt ttgtttggga ggtttttcaa aaaaatttag ttagaataag tcctttgaga 33061 aacatcacag taggttaaac aaagttaggt taaattaggc tcctaagttt gacttctcag 33121 caaacttcta ctgaatgttc tgactgtaag cccaggattg catgacaaaa cctctagtct 33181 gaagttactc accttgacag gttggttctg gagatgacca gtttccaaat ggtccacagg 33241 tggtttcttc aatcccagtt aagtttgttc cttcagagca gctgaaggca cactgtgagc 33301 tgaagctgaa gtttcccaaa gggtgagtac agtccatggt acccagctct ggggcctcca 33361 aaggctcaca ctgaatcact tcaataggga aagaaacagt atggggaaga gttaagagga 33421 actgacgcct ggatttgaat cctagccctg ccacttgata accatgtgcc tttaaacaag 33481 gttacttgaa ccctccaact tcagtttctt catctatata agaggaataa tgaaattgtg 33541 ttatctttat caaattgata tggaaactaa atgtaattca attagcataa gtcaaggacc 33601 ttagaacaaa gcctgactca tcagaaattc taagtaaaca ttagctagtc ttcatattat 33661 tatcttcagc attatctgta gtgagaatcc ttaaagccaa ataggtgtaa ctgggaatga 33721 ccagcttagt cgggaaataa ctatcacatc agagcccctg agtctactag agtattggga 33781 gcaagatgtt cagagaaaga gtgggtctcc ataataagcc ttctttgcaa ggagagaata 33841 taaaagtcta ggaagcattt tgacctcaat tctgtcttct attctagctc agttccagaa 33901 ttttaactct tttgattttg acaaccctct ccagaaactg tatctatttc cctgttctga 33961 ttggtggtac aataggtaaa tttaagactt ggaaatcaaa gttttcacat tttagaccct 34021 gccatgccat ttagtaaaca gtacaacttt catgtcttat tcctcatctg tcaaatttaa 34081 gccattattg ctaccttgct ctagagactt caaggaagaa tggactcaag gaatcagaag 34141 aatttttgta tttggaaact atatgagatg agattaggga gaaacatggg aactaagaga 34201 aaatgttatc ttttttcatt gatttaaaga gtatctatta tatatcaagc attactctgg 34261 ggcttgaaga gcttagattt caccctgtag gacaaaatgg taggtagaaa ttaatgggtg 34321 gattgtcatg tatgtgtgat gtgttttaat tgcttttaat tgatcagtct ccctgtagta 34381 tgaataatgt atttgagggg agctaattta aaattgtgga actcatctaa taaactattg 34441 caagaatcta gaagaaagat aatgacggca atggtagtag agttgacaag tggaagacaa 34501 attagaaaaa cactaagttg taaaaattgg tagaatgtta ccctgcataa atgttggggg 34561 agttaagaga gtctcatacc agggtgccca tgtaaatggt gattccacat actgagataa 34621 gaaatacgaa gagaaaagct gactgggaac aattggtttt atagtctttt aaacatccca 34681 aaggacatcc ttagcatatt tgagttcaga gctggagata ggcttatcag tccaaagatc 34741 acatagattt gtgagtccgc aaaagtcagt aagtttgacc aaaggataca tgtagattag 34801 agtcagaaga gcaatataca aaagacaaaa gctgagaaat tatagtagtt tatggtcctg 34861 gataagtgct catgaaggat ctcaggagaa atgatcacag gtagaaagaa tgagaaaaga 34921 gtgatatgag agaaaccaag acaaagaaaa gtaaaatgtt aaaaatgagt gaaataggca 34981 taccaataat taaaaatgag taaaataggc ataccaataa cataagggtt aaaaaataga 35041 gttcaaaaat ggggtgaggg taaagtatta ggaaggagtc atggcccagg gatcaagtga 35101 aatgagttag atctatagat ctatttcagt tggttgacat ttaaatgtat tttggtttta 35161 attctttatt gtttacaaac attgcttttt taaaaaatta aattgtccaa ttcaattcag 35221 gctcacaagc aagtgcctca tatatacagg cattttgtgg atcccaaaga tgcaatgata 35281 aataggacac ttactgatct caagaagttt tcagtaccag aggagacgga caagtgaaca 35341 gatgacttca acataagtgg gagaaatgag gaagaaatat gtggagctat cagaactaag 35401 aaagcttcct agaagaaact gtctttgaac aatgtcttaa agatgacatg ttttttggcc 35461 atgtgcaaaa tgagagagaa ggccaccagc aaagtcagtg tgctacagag cacatgtgtt 35521 aagtgtggag aactgcaaga aggaaaggaa ctactagaag gaaaaagcaa gatactttct 35581 gggtaactca gcctcctaat gataaatggc atagtttctt ccagacctta gagttctaat 35641 taatctaaca agctcattag atcgtgagct tcttgagagc gggaatctac catgctaatt 35701 ccttatggta accctgacag cttttatccc aacactgtgc ttcttgtggt actcaaaaag 35761 acttgttgag aagtgagtcg aaacttcatg ctgacttatg aaatctttac ggaaaggtaa 35821 caatattgtg aaagcagagc tttctgatca aaacttccca tttctcagag tggctagtat 35881 cattttgttc caaccagctt catgataagc tataatgatt cctgtgactt tacctaagaa 35941 gaagcaaaga aaggaaagag acttaccaaa ctgacactgg ggcccatagt accccacatc 36001 acagttgcag gtgtaattat tgatgatttc tacacattct ccatggccac tgcatgacca 36061 gggctggcaa gaagctttaa ggaggtcaga aaaaaaatat tttaatgtga ttacatttta 36121 gtactcaaag tcatttcttt agacatagat aaccttttgt ctgagatgat ttaaataatc 36181 aggaaaggtt tatttgtaaa ttcatagcat aaaaatcata tgctaaaatt tttacgtata 36241 aaatacacta agcatatagt cataggcatt tatttgcttt tggaatgaaa ttaccaatac 36301 taatattctg taacacttat aggaaactta gtggcatacc ttgaaactct tgaaattact 36361 tgtttttaat gagtgagaag gttaaatgat gacctgacet caatcatttc tgcatgcaat 36421 tatttcttgg caatcccttt ctttatagaa atcaaagatt aaaaagtcca aatttgctaa 36481 aacggtagag tccaatttat aagagaccaa attaactatg gttcattatt aaaacatcac 36541 ttggaaaatg ctggctgttt tggaattgta gaagatttta cagaaatatt catacaccaa 36601 agatagtgca atttttatat aaaattatat aaggttagac caagaaggaa gcacgcagca 36661 ccacactctc tacttcacaa tgtgaaaact gaggtgatgt gagcctaagt ttccaactgg 36721 ccccagctgt cagcttctcc tcccctgcct tattatcaaa ggcactgatt gtctagctct 36781 tcctctgtac ttcctacgta gatctatcat tttgatgtaa cttgatttag gggtatagct 36841 tttgtgcaca gggacaaatc ttacacacca aaaattctta ggagtgacac gatgcaagat 36901 tatatagagg gctagatgta ttttagaatg aaccagaagc tgttctcatc cccccacctt EPI-109 925

36961 tccatggggt aaatctgagt attctcttaa ccgtggccct tcctgagtct gaggcagcat

37021 agccgtcttg tcactcccta cctgtgtaac agagggctgc ctttagtttg tggcaggcgt

37081 catcgttcca tttgcctgca tctttgtttc tcttgatata gatctccacg cagtcctcct

37141 tgttcttctt gttgttgggc tcaccatctc cccagttctc tgcttcttca gtaagagatt

37201 tgttggttcc cacccacgtc catattcctc ctatcttccg gattcctatc cagtagtaag

37261 aacgactgaa aggcagagtc ttctccagat actcaatttc cgccttgttt tgtatggcaa

37321 ctaaatctgt gtaattgtct cggcagaatc ttctagccct ttgccagttc atgggttttt

37381 cagaataatg gtaagtccag cagtcggttc catgatgtgc caggaaatct gcaagacatc

37441 agtgtgacct atgcagactt acataatgtt acagctaaaa agaacctagc actactccag

37501 gctgagctag acacttagag atgaggaaac agagcctaag agtgtatgtg accatctcag

37561 gatcacagaa tagttgtttg cagatttgaa gtagaaccta gaccttctgg cttgaatata

37621 agatgctttt atctaaggtt ctatttgaaa caaatttagt ggttttctag gtttattttc 37681 ttattaattt ttttctcaaa attatttcag gtgaaattta accaacatat tttagacatt 37741 catatttctt tttctttgta gctgttaatg atttacaact aattaccgtg taatatcata 37801 taactataca atttacgtat actttttaat cctggaatca tttcttgaag gccaacacat 37861 atgtacctat gggagaagca taataaggac aggaagaaca gtgacatact tttaagtaac 37921 ctcttttaca taaaaaacat tttattttac cataggaaga actgcttctg gaaaagccca 37981 atataccact caactcttat atatctaact gtataatttt taaaaagaac aatttacaaa 38041 gccaaatggt ataggattat gaaattcatt agatcatgtt ctatacacaa agagactcaa 38101 ctgatgatgt ttaataaaca tatggaccca tcaaatatga gggctttgaa gatatctaat 38161 taaacacata attacacaat gacttcataa taatatatgg cattctaagc atggtatgat 38221 ctacatgaat cactatttaa tacagtaaag aaacagatat aattgatggt aaagagcatc 38281 ataaaataaa cattttgaac agagttttga atgagcattc cactagaatg caagttctaa 38341 gagggaaaaa actgttgtgt ccactgctgt atccttagtg cctagcataa atttcacaca 38401 ttgtagggac tcagaaaata cctgttgtat gaaaagagea ctaagtttct atgtgacaca 38461 gtgcagacat ggcataagga atgtgtgaac gggagagtta gcatgtttgc ttggctagag 38521 ctgaaaatcc aggctaggga gaaagaagac attagtttac ttaggaaatg aaaaaccaag 38581 ttcaaagcta ttgctggaga gtcttcaaga atcagatata aaatttgtca caacaatggg

38641 agaaggacca aaaaatgata aacccccgtc ccttaataag ctcgtattgt aattgtagaa 38701 atgacattaa tgtacactga actatgaata aaaaatagaa aatgaggtgc taaatatttg 38761 gtacagattg taagtacctt aacagagatt tcttaattaa cattattcct ttataattga 38821 gggattttgt ggggttattg ggatttgaac tctacagcat gggctattat aggttaaaaa 38881 tagtgttcag gagtttctgg ggaagaacta aaggtaagaa gaaaagagat gtttacagaa 38941 gggatagaat taacagctc.t gtgaaataat tttcccttag actatgtata actagtggat 39001 atttaagaaa aatgaatata agtaaaatag acttagcgat atataaatat cataacatac 39061 cacaacagag cattgtccac ccccacaact tgaagatgtt ccataagtcc ctctgggtgc 39121 tctgacattt ccatggaaat atctgcaaat gaaatacaaa attatattta gatgtatact 39181 cttaaaccac acatttatag cctttgaggt ggtgcttaca actttcttaa taatcagaat 39241 aaaacacata tgtctactaa ccctgtctga ggtaacaggt ttctcagaca tagatgaaaa 39301 attacttcaa atttacatca gaactgatgc acagttttgt tttgttctat tttattttta 39361 cgctttagtc tcaagttgct aatcggtact gccctgaatt ttttctatgg tttggtaatt 39421 tttatacctg cttttctgct gagctattag ataaaactat ttaatattta ctatgtatat 39481 tttttaaagt attgttgctg cttaattaac tattgatgct tatatttaat gttatagcct 39541 cactcttgat cataatgggt caatgcctca aatacctaaa aaaaaaaaaa attagatagc 39601 cagacaccag gaaagaaaag tatttctttt tttaataaaa agaaatacct ttttgagcaa 39661 ctgaaatgac aaagtcacaa atttcctgca caccttaaaa tatacttaat gtaaatgacg 39721 agttaatggg tgcagcacac caacatggca catgtataca tgtgtgacaa acctgtatgt 39781 tgtgcacatg taccctagaa cttaaagtat aattttaaaa aaattctatc ttccaaagca 39841 tatcacttct caggtagaca cagtgtttat tgcaaaagat ctgatttcaa tagtatttct 39901 tcaagagtct ccccagagac aaagtcaaga agaggaaatc agcatatctg agaagaaaga 39961 tttcaggatc actttttttg agggtctgag aaaatgttta gtttctatat tatttaaaac 40021 cagaattgaa atggggtgat tcctatcctt gccacctgcc tctacaaccc caagagtttc 40081 tatctgagca tctaaacgtc ttttaggctg aaaggctcac catggctttg cttggtcctt 40141 ctctagttct tctgcagccc attgagcctc ttgacttagc acaagggtct caggtccttg 40201 cccaaaggga gtgtgctgtg ctgcaggtag actgcactga atgtcaacag aaagccttgc 40261 tttctttcat ttctctaacc cagtctcaca tcctcctcct cctccccttt tccctcccct 40321 tcctcctgca cttctctttc ctctttcccc acccctttcc tagactggcc tctattgcct 40381 cccactgaga caaaaatgaa ctgctgatca gaaagtaatg tgactagatt ctctcttcct 40441 tccctccttt ctatccttcc ttccattctc ctatgcatct ttccttaccc tcctcctcct 40501 tcactcattg ttgttgctgt tcttcttcct cttctttttc ctcctgctcc tcttcttcta 40561 cttgttcttg ttcttgtttt tgtttggttc ttgttctcct cttcctcctt ctctctctcc 40621 tcctcctcct tcttttcca.c caccctcccc tatctttttc ataaatgcta aactaactct 40681 tggctacctg tggtaaatgg cccttggaaa ttgcaaatac tacaaatcaa aactgcattt 40741 cagacatatt tatgatgttt gcaaaacttc agtagagcta agcagtggac ttgactcgtt 40801 tcggttcctt cacctccgtc tttccttgct caccacctag tggacgtcct tgttagtggc 40861 acttcctgaa gttaacccct gaagagagcc catgctctct agcttttcac cgtgtaggtt 40921 tgggagccta caagtacctt taatattctt ggactataaa atgagatggt tttataagac 40981 tgcatgtgaa attaggaccc atatgatgaa ggacaataaa aaggaagacc cactgatgtg 41041 agtcaatgag tcaaatgcaa atcagatttg catttttagg aaaataataa taacaacaac 41101 aaaaactctg aagctcagcg ccccatattt attatattgt ttaatcttta taacagctct 41161 ctgctataga tatgattatt atccccattc taaagagtct caaagaggtt aagaaacaaa 41221 ttcaaaaact agcgaaagac aagaaataac taagatcaga gcagaaccat aggaggtaga 41281 gacacgaaaa agccttcaaa aaatcaataa atccaggagc tgcattttga aaagattaac 41341 aaaatagatg gaccactagc tagactaata agaaagaaga atcaatagac acaataaaaa 41401 atggtaaagg ggatattacc actgatcccg tagaaataca aactaccatc agagattact EPI-109 926

41461 ataaacatct ttacacaaat aaactagaaa atctagaaga aatggataaa ttcctggaca 41521 catacaccct cccaagacta aaccaggaag aagtcaaatc cctgaataga ctaataacaa 41581 gttctgaaat taaggcagca attaatagcc taccaactaa aaaaagccca ggaccagatg 41641 gattcacagc caaattctac cagaggtaca aagaggtgct ggtaccattc cttctgaaac 41701 tattccagag aatagaaaaa gaggaactcc tccctcactc attttatgag gccagcatca 41761 tcctgatact aaaacctggc agagacacaa caaaaaaaga aaatttcagg ccaatatccc 41821 tgatgaacat cattgcgaaa atactcaata aaatacggca aactgaatcc agcagcacat 41881 caaaaagctt atcaaccaca atcaagttgg cttcatccct ggaatgcaag gctggttcaa 41941 catacacaaa tcaataaaca gaatccatta cgtaaacaga accaatcaca aaaaccacgt 42001 gattatctca atagatgcag aaaaggcctt ggataaaatt caacacccct tcatgctaaa 42061 aactctcaat aaactaggta ttgatggaac gtatctcaaa ataataagag ctatttatga 42121 caaacccaca gccaatagca tactgaatgg gcaaaaactg aaagcgttcc ctttaaaaac 42181 tggcacaaga caagtatgcc tctctcacca ctcctgttca acatagtatt ggaagttctg 42241 gccagggcaa tcaggcaaga gaaagaaata aagtgtattc aaatagaaga gaggaagtca 42301 aattgtgtct gtttgcagat gacatgattg tatatttaga aaatcccatt gtctcagccc 42361 aaaatctcct taaactgatc agcaacttca gcaaagtctc aggttacaaa atcaatgtga 42421 aaaaatcaca agaattccta tacagcaata atagacaaac agagagccaa atcatgagtg 42481 aactcccatt cacgattgct acaaagagaa taaaatacct aggaatccaa cttacaagga 42541 atgtgaagga cctattcaag gagaactaca aaccactgct caaggaaata agagaggaca 42601 caaatgaatg gaaaaacatt ccatgctcat gggtaggaag aatcaatatc atgaaaatga 42661 ccatactgcc caaggtaatt tatagattca gtgctatccc catcaagcta ctactgactt 42721 ttttcacaga attagaaaaa aactacttta aatttcatat ggaaccaaaa aagagcttgt 42781 atagccaaga caatcctaag caaaaagaac aaagctggag gcatcatgct acctgacttc 42841 aaactatact acaaggctat agtaaccaaa acagcatggt gctggtacaa aaacagatat 42901 atggaccaac ggaacagaac agaggcatca gaaataacac cacacatcta caaccatctg 42961 atctttgaca aagctgacaa aaagaagcaa ttgggaaagg attccccatt taataaatga 43021 tgttgggaaa actggctagc catatgcaga aaactgaaac tggatccctt ccttacacct 43081 tatataaaaa ttaactcaag atggattaaa gacttaaatg gaagacctaa aaccataaaa 43141 attctaggag aaaacctagg caataccatt caggacgtag gtatgggcaa agacttcatg 43201 actaaaacac caaaagcaac agcaacaaaa gccaaaattg acaaatggga tctaattaaa 43261 ctaaagagct tctgcacagt agaaaaaaaa aaactatcat caaagtgaac aggaaaccta 43321 cagaatggga gaaaattttt gcaatctatt cacctgacaa agggctaata tccaaaatct 43381 acaagaaact taaacaaatt tacaagaaaa aacaaacaac accatcaaaa agtgagtgaa 43441 ggatatgaac agatgcttct caaaagaaga agtttatgca gtcaacaaac atatgaaaaa 43501 aagctcatca tcactggtca ttagagaaat gcaaatcaaa accacaatga gatgccatct 43561 catgccagtt agaatggcga ttattaaaaa gtcaggaaac aacagatgct ggagaggatg 43621 tggagaaata agaatgcttt ttacagtgtt ggtggaagtg taaattagtt caatcattgt 43681 ggaagacaat gtggcgattt ctcaaggatc tataactaga aaaaccattt gacccagcaa 43741 tcccattact gggtatatac ccaaaggatt ataaatcatt ctacgataaa gacacatgca 43801 cacttatgtt tattgaggca ctattcacaa cagcaaagag ttggaaccaa cccaaatgcc 43861 caccaatgat aaactggata aagatgatgt ggcacatata catcatggaa tactatacag 43921 ccataaaaaa ggatgagttc atgtcctttg cagggacatg gatgaagctg gaaaccgtca 43981 ttctcagcaa actaacactg gaacagaaaa ccaaacatta cccattctca ctcataagtg 44041 ggagttgaac aatgagaaca catggacaca gggaggggaa catcacacac tggggcatgt 44101 caggggatgt ggggctaggg gaggaacagc attaggagaa atacctaatg tagatgacag 44161 gttgatgaat gcagcaaacc accatggcac atgtatacct atgtaacaaa cctgcacgtt 44221 ctgctcatgt atcccagaaa ttaaagtata atttaaaaaa agtttaaaaa aagaaagttg 44281 ccttagtcac ataactagta agagacatgg ttgggaattt gaacagaggc caatcagttc 44341 caaatccatg ctcttgatca ttaagctgaa cttatggcag gaacttggaa gacatggtaa 44401 aatggggaaa aacgtggagc cagggagact tgtgaaagtg ccagtgctcc cactataccc 44461 tgaaagaagt atctagactt acttttttct aagtcctctc ctctaattct ctcaatctct 44521 ctctctcttt ctctaagaga tgggaatgct gctctgtcac tcaggctaga gtgcagtggt 44581 gcgatcatag ctcattgcac tcaaggaatc ctagggtcta gtgccccttc tccctcagcc 44641 tcccatgtag ctaagactac aggcacatgc cccaaccctc gactaatttt tttatttttt 44701 atttttgtag agacaggatc tcactatgtt gctcaggctg taattctgtc ttgaagcttg 44761 tccaatcagg ctttcagcca caccaattcc ctgagactgc tctcaccaag gtcctacact 44821 tcactaacac aaacagccta ttctccatcc tcatcttact tcaccaggga gctcctggtt 44881 ttcctcctac ttcactggct atttcttctg tatcatgtgt tgattctccc tcatctcccc 44941 aacctccaaa cccttggagt actccagaga tcaccgcttt gctcttctgt gtctaacctc 45001 actaacttgg tggtccaatt cacactcttg actttgaata ccatttaaat gcgaacgaat 45061 tctaaattct gtacaaccag aaccattctc ctgtagccaa atgcctactc aacatctcca 45121 tccccaaaca aatttagttg ttcaataagc ctctcatatt ttacatatcc caaactgaac 45181 ttctgaattt ctcctccaat ctgtagggct cttcccacag cctttccatc tcagtggatt 45241 ataactccat ccttccagtt actcagacca aaacttttgg agttaactga gacacctctc 45301 ttttttttca caagtcatat ccaatgtgtc aacaaatttt ggtagtggaa atattgcggg 45361 attttttaag aaatcagaga gaccgatggg gttcaggagg atatttatta tttaggtgca 45421 ctggccaagt cagattaaca tccaaaggac tgagccctga acaaagagtt aagttacctt 45481 ttaagcattt tgtggggtgg gagagagggg tatctgtgca gggggaagca tactacagaa 45541 gtgagaaata aagacagtta ttcaattaat tgagacatgc attacatcat ttcttacttt 45601 tcaagaagaa acatgttttg cgacttgagt ttatctgtct agtgaccttg cagctgcaca 45661 gctagagaaa cagggtcttc acaatgcctg ggaaaggagg agaggtaagt ctcactagcc 45721 acagaaaaac aggcagttaa tttttaaagg gctccagctc tttctctttc tcagggggag 45781 ttgggttttg ttacatacaa ctgagtttcc gcttacacat tatttaattt cttttaattc 45841 ctgttccaaa agaagccaga tacaaaaggt tacatgttgt ctgattccat ttatatgaaa 45901 catatagaag aggtaaatcc atagagacag aaagtagatt agaggttccc aggggctgag EPI-109 927

45961 gaagaaatgg ggactaactg cttatagggt acagagtttt cttctgataa aaatattttg 46021 gaactagata gacattttgt taggccattc ttgcattgtt ataaagaatt acctgagact 46081 tggtaattta taaagaaaag atgtttaatt ggcttacact tctgcaagct ttacaggaag 46141 catggtgccg atatctgctc agcttctggt aaggcctcag gaagcttaca atcatggcag 46201 aaggtgaaag gggagcaggc atatcacata gcaaaagcag gagcaagaga gggatgtggg 46261 gaggtgacag tcacttttaa acagccagat cttgtgagaa ctcattcact atcatgaaga 46321 cagtaccaag aggatggtac taaatcattc atgagaaacc ccaccctcat gatcaaatca 46381 cctcccacca ggccccacct ccaacactgg ggattacaat ttgacatgag atttgagtga 46441 gaacacggat ccaaaccata tcagagatgg tggttataca atgcgataaa cgtcactgga 46501 ttgtacactt taagatggtt gttttatgtt gtgtgaactt cacctcaata aaaaaaaata 46561 tttaatgtac attcagccaa aagaagattt ggaataggaa aggtcatgga gatatattaa 46621 cagccatttg atgggtggta aggaaaagag tggttattag actgttttgt ggccctcaaa 46681 aggtagaact agatcgagtt ggtgagcatt ataaaaccat cacaaaaccc tggagagagg 46741 acccagtgct gaagaaccgt ttgcctgcca tgagacatga gggaagtacc agtgaatgcc 46801 attgaaagca gcatccctgg gtccaaggga tggtcaaagg accactaccc aacccttccc 46861 tagcctacgc ctccattaca gatgaccgca agatttattt gctcattgct gccaaccaag 46921 gctgcactca ctgcagttgc tatcagttta tcatgggtaa aaggaatgtg cagtagagaa 46981 ctaactaact gcccacctac ctccacaatc ctatcaggac aaatcaccat ggctcacatt 47041 tccttacatt tggcatgtaa gcccctctta ctgtctgtca tctatctcct acacagttca 47101 cctaaactgt tctctcctga cccaaccttg attttcatcc caaatgcttc cttgccatct 47161 ctgggattcc tgtcttcacc atcaccaaac tcccctcaat cttccagttt cctgttcaaa 47221 cttttctcct acctccttg.c tttgtcatta gcccgactgc ctccctagga catcacttcc 47281 cctgcagatc tctcaagatg acaatattta ttctccacac agcacatact tcagggttgg 47341 aaggcagggg caatcttctc ctttataatg agtgcctctt atatatgttt attcatctgc 47401 cctcttgtaa aacacacaca cacacacaca caaagaagaa ataaaataac tctgcttctt 47461 tgaagcttgt gacactgaga taaaccatct cactgtcctc attgtagtga cctctcaact 47521 cctcatgcaa gattggcttt ggcacctagt tcctgatctt cctttccctg taagcacttc 47581 tcatagtctt acgggacttc accatccatg gcacaaccaa taccacagcc cagatcctca 47641 gctctccaat gacattttcc tccactagac ttgagctacc tccttcccta ggcacagcct 47701 caacctcgac aacacctaag actgtaccgt ctctaaagtc acatgttcaa acacttcact 47761 ctttaaccac tgtctcctat tcttgcaagt gtattgctca agtatctcat tgcaatgctt 47821 tttacttcta cctcattgaa cctccaggcc attaaacatt tccttatttc taaccatcag 47881 gtttctcctt acttgtttgt ttgtttattt gtttcttttt tttttttttt tttgagacag 47941 ggtctcactc tgttgcccag gctggagtgc agtggtatga tctcggctca ctgcagcctc 48001 catctccctg gttcaagtga ttctcatgtc tcagcctccc gagtagctgg gactacaggt 48061 gcatgccact acgcctggct aagattttgt atttttatta gagaaggggt tttgccatgt 48121 tggccaagct ggtctcgaac tcctaacctc aggtgatcca cctgcctcag cctcccaaag 48181 tgctgagatt ataggcatga gccactatgc cccacctggt ttctccttat ttatttcaag 48241 tctatgctgc actattaaaa ctgccttgac aaaaattata atagtgagaa aattatgaca 48301 gtgaaagaga tctgaaataa tcaaccccca tcttgccttt accttccaga ctgcccttaa 48361 taattcctga gcttgggcca agctatcttt ggcagaaatt tagtttatag tttaaatgat 48421 aatagccctt ctccaaaact aaactgcctt tgtaaaacta ataaaagacc accaatgaaa 48481 ggttaggagg atgagaggag cctgaattct gctaaggtgt agatgtaaac aattaccaac 48541 tgttattccg gaggtcacaa gatttgcaac atcgccaatt actcctgcag ataacagcac 48601 tatcatagaa tctgattggc cttttgagat gtcttttcag attcttacat ttcaactggt 48661 ggctctacct ggacccatca acaagtcctg tggctccacc cagaagcaga cttaacatgc 48721 acaaggacca ttttccacac cgctatgatt gcatcccaac caatcagcag caaccattcc 48781 tctgcctgcc aaattatcct tgaaaaatct tagccttaga attttggggg aggctgattt 48841 cagtaataac aaaaccccgg tctcccattt ggctggctct gcatgaatta aattctttct 48901 ctattgcagt tcccatcttg ataaatcacc tttatctggg cagcaaacaa aaggaaccca 48961 ttggacagtt acactgttgg cagatatatc ttgcttccaa aattggattt ttgtttaatg 49021 aatttattct gttttcttga tatttacaac tgtgaatgtt gtgtctgaat tctctttatt 49081 tcttgttgaa aagaactata ttgctacagc cagtacatac agatggatag ctaattactc 49141 aacacggggg gatgtgacca tcaccgcact gtgcaaatga atgttaccca ttgtccactt 49201 ttcccaaact acatagtgtt atatggtata tgacccaatc aacggtggca aagctccaga 49261 aataccacat agacatcagg gacactttaa actaatcagc ctatagtcct ttttcagtaa 49321 tttccaaacc tggttgtgca tccaaatcac ttggtaacat taaaaaaaca aaaaaatata 49381 cacgcaacat tcgctcccaa tcctactgaa tcagaatatt ttgggttggt tcaggaacat 49441 tcaggagttt ttcagggtcc aaggtttata taatttgagg tctctctttg agaaaaggaa 49501 cgtaaaagcg tcttgctttt atagatctta caaagatgta ttaccatgta aacacattcc 49561 taggacccag gcccttgtaa tttaaaggtt tatctaagta atgggccctg aagcttaatt 49621 ttcattatct tcagggcaaa ttacctgtgg gttagggttt aggaatatat ctctctgtgt 49681 atgtgtgtgc acattagcat gtacgcttgt gtggattttt tttttttttt tttttttttc 49741 tgagacagag tctcgctctg tcgccaggct ggagtgcagt ggcgtgatct ctgctcactg 49801 caaactccgc ctcccaggct caagcgattc ttctgcctca gcctcttgag tagctgggac 49861 tataggcacg caccactatg cccagctaat ttttgtattt ttagtagagt tggggtttcg 49921 ccatgttggc caggatggtc ttgatctctt gacctcgtga tccacccgcc tccacctccc 49981 aaagtgctgg gattacaggc gtgagtcacc atgcccagca cttgtgtgga tgttttaagc 50041 tcccaggtga gtgaatacaa aactagatct ttcccttctg tagcatctgt actgtttact 50101 ctatgcatct caatattttt tcttttagta tctttccttt ttctctctta ttacttcctc 50161 ttgtgctatt tttacacctc cttttttaaa aaattttttc ccttttattt ctattgacct 50221 ttagccctca caatgattcc tacaagcccc atttctgtaa atggggattg aaataattgc 50281 tggacttttg agagatagat atattaaatt gcaaactggc agtagtgggg gcagttgata 50341 cataactagg ttttaaagtc tagccttctg agaccactca ttccatttgt gaaaagtgat 50401 tctacttctt attatgagcc aaaatatgca ttcattcacc catgcattga tttattcatt EPI-109 928

50461 caataaatat ttgttggatg tccactctgt atcaggaatg tgctaggttc tgggaataca

50521 gcaatgaaca aggtaatttt tccctacccc taaggaactt agagtttagt ggggaagaca

50581 gacattaaac aaacaattgt gcaagtaata atctataatt atttattaca attaaaggaa

50641 ggaagagaca tatggattat gagggcatta aagaggagac ctagtgtaag tagccagttc

50701 tcgtgaaggg acatgtatta gttggagttc tccagagaaa cagaaccaat ggtgtgtgtg

50761 tgtgtgtgtg cgtgtgtgcg tgtgtgtgtt ggggtgtggg ggtgtggtat tttttataga

50821 aattgtctca cacaattatg gaagctgaga agtcccatgg cctgctgtct acgagctgag

50881 aaccaggaaa gccagtggaa tacttcaaag tccaaaggcc ctggaaccaa gagtgccagt

50941 gttggaaggc aggagaagat gggtgtccca gcttaaaaag acagtgaatt cactcttttt

51001 gctctacata gggcctcaat gggttggatc atggccaccc acattggtga aggcaatcct

51061 cttagtctac caattaaata ctaatctctt tggaaatact ctcacagaca cactgagaaa

51121 taatgtttta tcagggtgat agaaatcttc tggagttaaa caatggtgat agctgtacaa

51181 tcacatacat ttttaaaggg tgcgttttat ggaaagtgag ttttatctaa ataaaatttc

51241 taagaaagag acttaacaca gagataaaca taagcacatt tattgtcaac ctttatagtg

51301 ttatgtcaaa taggtctgac ataagcttaa ataaatatat actttaaaaa ttataaaata

51361 ttttaagtta taatttaaaa ttctcaataa aactcaaaca caaaccacac tggtatttca

51421 cacagctaat ttctaatgca gtttacataa atatttacaa cacttaaaca atttcaaaga

51481 aaataacact gtattccata catagcctga tcacagtagt tgttctctct tatttcccag

51541 agtttttctg cccctttaaa agaacctctg ctgttctgat ccttatcaca tctctgtttt

51601 gactgttggc tttgttgttg ccagtgttca gccagaactt ctctgaaact tttttttcaa

51661 cacatgctaa gttaatggaa gtgtaggaga gttttgattc tcacactcct caaggctaga

51721 gcagctttgg caattactga ctgagaattt ttcattgcca gtgatcaact gaaaactgga

51781 gattcctttg gaattgttaa atctgcttat aaataaacat aaatgcttgc tcacacaggc

51841 attcctctct tccagagcac cctaacatac agaagaaaac aaatagggaa taactattag

51901 acatcttcat tcgttaaaaa tctaccagat gactctttta catggtgagt ttctattgtg

51961 aatttaaaat cttccataat atacaagaat tatgtttaca tatcatatct gacaaacatc

52021 tttgtaggaa tgcaaagcac atccatcttt ctgtattctt ttccaacaaa gacattcata

52081 aaattatacc tttgtgtgtt tgcatttatg cttttattag ttcaaaacgt ttggcctcat

52141 ggaagttttt catcgtggaa accacatatt tctgaaaaaa tatctgacaa tatacaaacc

52201 ttccattcag tttttactct ccaattctac catgttttca aaaaacaact gtagtaaaaa

52261 cactcagaac tttattctgg ttaacatcat gccttgctag gggacaatag tttccctttt

52321 tgaaataaat ttaaaacaga tgtaacataa tttgttaata aacaatgagg gggtaatcta

52381 gaataagtaa cttttaccat atcatagttg acagcattta caagtttttt aagtccctac

52441 cacacttgta ttgaatgaag aagtatggaa gattataata tattcaatgc aagtaaaaat

52501 atcacaatcc ttaagaactc tttaagaagc actgaatccc atagggatga aagtgattaa

52561 attgtgcata gtaaccctcg cacagagcat tcagtaggat ttgcaccatt aacaaccctc

52621 catgcatttg cctgtgggca ttcaacatct gtcatttttt taagttataa tatttttagt

52681 catttttttc ctctaaactc tggataatta ttattcattc ttatgacagc aactgtgtaa

52741 tcagctgtcg aaacactgtg aagggcaaaa gaaagaaagc cacaaaatat tgtgtttctg

52801 tgccaagatt ttacagcgag caagggagag ttagaaaagg aattctgaga tttcagagtc

52861 ttggtctctt cacctttgct tggaagaaaa tatcctttcc cttcattagc caacactttc

52921 ttgatcctga gagtaggaaa gggaacactg agtcttttca gttgaaggcc gtccttgcct

52981 gctggacttt gatctattga agtggtgatg ggtgttgcgg tttcagccat aaaggcatct

53041 ggcatagtag gcaagaaggg ccagagaccc gaggagagtt atctgtctct gttaacttca

53101 gtgtatccct ctagttcccc agatgcacct gtttctgtaa atataaacat gcatgtcatc

53161 agaacactta atattctgca tactgatcat gacaacaaaa tgtaccttct aacacagaca

53221 ctctcactag gatagaccat gtaggaacat cgaattctat tcagttagga cagtgatgat

53281 gtctacatat tatacctctg tcaaaaccta cagaatatac aacacagcac agagtgaatt

53341 ctaatgtagc ctgtggacat taatgaataa taatgtatca atattggccc atcagttgta

53401 acactaatat aagatgttaa taacaggggg aattgaaggg gtggtgggga gatatgttgg

53461 aactctttgt gctttctgct caatttttct gtaaacttaa aaccgcacac acaaaaaaag

53521 ttattttaat tttttaaaaa gtattcagag ggacttgacc tttccaaatt ctctcaaagc

53581 aggtcggagt agttaagaac acaaatttta gaaccagact gccagagttt gaatcctggc

53641 tacaccactt actagctttg agatttcaga caatttactt aacttctctg tctcattttc

53701 ttcatctgtg tgataagaaa taaagtaaca ggccaggccc agtggctcac gcctgtaatc

53761 ccagcacttt gagaggccaa ggcgggtgga tcaggagttc aagatcagcc tggccaacat

53821 gacgaaaaaa tacaaaatct ctactaaaaa tacaaaaatt agctgggtgt ggtggcaggc

53881 acctgtaatc ccagctactc aggaggctga ggcaggagaa ttgcttgaac gcaggaggtg

53941 gaggttgcag tgagccaaga tcatgccact gcactccagt ctaggcaaca gaatgagact

54001 ccatctcaaa attaaaaaaa aaaaaagtaa aaagaaaaga taagaaatat agtaccagcc

54061 cctatctcag agttcctagc ttagaaaaat tcccagaata taataagtgc aatgtaaggg

54121 tcagctatct tcattattat tatctatcat aaatgaaatt acacaataaa gctagatccg

54181 tttctttcct ctccttctac aaaaaataaa gcaactttcc agaacaatac ccaggtgatg

54241 atttctcccc tgctccctcc ctaagatatt ggcaagtttg gagggttcaa ggagaaacag

54301 agcatgtaga gaagatacct ctctcataac catttgtgat ttacaagtct tacctgattc

54361 ttttgaactt aaaggatgta agaaggcttt tggtagcttc catctgattc aaggctttgg

54421 cagctgctgt ggaatacatg agaacactag gtaaagcact gtcttccaac atgaagagag

54481 aaaaatatgt ggaatgttca atggcatgct ttgtataaga atgcaactta cctggcagga

54541 acaaatttct ttgctgcaaa agaaaagaca aacaaccatt aattcagact aaatgacttt

54601 taaggatata ttaaatccag atacaatatg acttaattca tcaagtgttg caaactcgat

54661 gcttcagggc ctctgtaata atcagagcac aagcatggct ctgtggcatc tagggtaaaa

54721 tgcaaagtgc acagccatcc aaagggcata gcagcttcct aatgccagca aatagctacg

54781 gggtcatctt gcccaattca gctcccaatt tttcatgaga agtccaaagt cttaatttaa

54841 atgtgagatt tcctattttg taaacgtcag aacttaactc aaaaatgttt taagtactct

54901 taaacatgta agccaaacaa accatgagtg tagtcagatg tgcttccata ttccttatga EPI-109 929

54961 gagactctca aatttaagcc tgtactccaa ataaatctcc ttaggaagaa ttttatccat 55021 tttccttaga gtgctcatca tggcagttcc attgcacaat tccgggaggc atcatataat 55081 tcaacatgaa tagcaccccc tggagttgta caatattagg cacgactaac atttttattt 55141 cctgaaacac ttcccacact gagttgtact actaactctt ttcttaatac ttctgcttaa 55201 ttatactgca ttttatccag attctaatta ttgtttaaat cagtaagcaa gaccatgact 55261 tatcaatgag aaagaaatgt attttcaaaa acatttttga agtacattca taaacttcct 55321 cacctttccg taagcatttc cgaagccaga ggagaaatgg tgctaatgtc aggagggaga 55381 gtccagcagc agaaagtcca gctaccaagg gaatgttgga ctcagtggga gctaaggaag 55441 taagagacga agaaaggtca tgaggaagaa ttgatgttaa agtctctccg tcctgtccct 55501 ttggcctttt ttctgtacat tcattactag gagcagaaga gctatctagt ttaatacaag 55561 aagcagagat gtggcattac aggcctttga gatctgctcc aagccacctt tgaagctatt 55621 tccaccattg gcaggcagaa ctctaacttg ccaagctcgt tcacaatacc acaccacacc 55681 ttggttaata aacactgcac ttgcttgctc tcttgctctc actccctctt gttttccatt 55741 tcccctttct cctctcctct ctctgtctcc tttttccagt tgtcagaatt ctaccctttc 55801 catcaacatg caacttctgt tttttctcta tccccataca acttaatatt cacaacttgt 55861 caacctgggc gaactttctg gtttggatat aatgaatagt tgattactgt aacaagatag 55921 ctcccccttt ttctttttaa tcaccagaca accaccatca atcaatgcat caccttcaca 55981 ggtaggtagc aggccagacc agtgtcctgt ggctccacat gtccgagctg cagagccatt 56041 gagcgtccat ccttcaggac aggcgaactt gcacacagtg ccaaacacgg gctccccact 56101 gcagctcatg ttgatctttc ccggaactgc caggcttgaa cattttacca ctgcaaatgt 56161 taggtacaca ggcagagttt cagaaaaatc tactggaaaa cttccaaaac ttgcttaaaa 56221 gtcaacaatg aatgtaaagt gtaagcgcta cttagttttc agcatgtagg aaattaggac 56281 caaacccctt tggggcaatc taggttcaga aactttatga agtatttgac ctgtacccta 56341 aaaaagtctg cactcaattc taccttggca ggaaggaacc tcttctgtcc attgtccctg 56401 agatgtgcac tcaagttgag ttgatccatg taattcaaat ccctcctcac agctgaaggc 56461 acaagaggac ttgtaggtga attctccaat aggggaatga gcacacctca ccaaaccctt 56521 cgggggctgg tggacagcat cgcatctcac agctggaaca cacgagagag cactttagaa 56581 gtttgtttgc atctccagca atacgtttcc caaggtaacc aagttcccaa gctcttcaat 56641 agttcttttt atcttaaaat aaaataaaaa caaagactgt accttcacat gtgggcttct 56701 cgttgtccca ctcccctgtg gggccacatt ggagcctttt ggatcccttc aacacaaaac 56761 cctgctcaca ggagaactca cagctggacc cataacggaa actgccagaa gcactaggaa 56821 gacaattcat gtagcctcgc tcggggttgg acaaggctgt gcactggaaa gctgagacat 56881 caaaatgatg gtcagaaaat attgcagtgg aactagagag tacttggcgt ttgttgagtg 56941 aacccagttc attcaagcaa cacttggaga actgaagatt ctttataatt ccctggacaa 57001 atgggaagat ggctgtgttt tctttgaatt tcagccccct cactgatcat ggcactaatt 57061 aaaagactaa ttaatcagaa cattagttcc tgagcactgt tcttctaaca cacaaaataa 57121 attatggtcc aaggaaagat ttcacgcagt ctgaggacaa catatgggtc atggatgttt 57181 atagatggtg ccaaaaagaa agaaaagaaa gcacccctat aaaatttgtc tgttttgcag 57241 tttggttttt gtgttatgtt ttgctactgg aaatcattct gtgctggctt tggctaggac 57301 aaggccagtg cctgatagta aaaactgctt gttttcaata tccttgctct cactttaaag 57361 tgaattaaaa tttactgctt atatatgcat caatactatc tctgtagctg acaccatgct 57421 tgaaacagtc tcatcactgc taattatgag ccatttcaga agacaggtgt gatgagagtt 57481 ttacattcaa atcatgttct cattattctg ctttccgaat tttctaatat gattccttta 57541 gattaagaat tctgtctatt ccatgctaat gtctacaaag ttttatcagc acatcacagt 57601 taaaaaaaaa cagcaaagaa ttcattctta acacatatga tcctttccct ggccaaacat 57661 tagttctttt aaatgaatct caaagatacg agggttgctc atcaaatctg atttctatag 57721 ttaaagtggg tattggtttt ttttttcact gtccaagttt gaagatggtt gttctttaag 57781 aaagtataaa tcgaaggatc tcaagcttac cttcacaaac tgggatttgc tgtgtccact 57841 gcccttgagt ggtgcattca acctgggctg gtccctgcaa catgaagcct tcctcacagg 57901 tgaagttgca ggatgatttg aaggtgaact ctccagcagg ggaatggctg cacctcacag 57961 agccattctg aggctggcgg acggccctgc atgtcacagc tgtaacaaat atacgcattg 58021 atattagcac ggcctagaat tagcttgccc atttccagta tgggttgaga gaaagaatgt 58081 tcacagtaag tctccatgtg gaacaactct acctttacac gttggcttct cgttgtccca 58141 attcccagat gaggtacact gaaggctctg ggctcccatt agttcaaatc cttcttcaca 58201 gtcaaatgta caggttgtgt tccatgggaa gcttccaggg ttttggaaac attccacgaa 58261 cccattggct ggatttgtca cagcatcaca ctcaaccact gaggatttta aagagcacca 58321 tgaattttac agaagaatga tcttttcact tcctattgag ctgggtgcct aacagagtga 58381 ggaagctgcc ttcaaagggt agatcccaaa gtcctatgtc aattcttagg gacatgcaca 58441 gccagaataa aagcttttat tctttttcat ggatattcta tcttttctga tttccacttt 58501 gcctatgctg agtggtctct aatctatgtt atcatttacg tgaggtaaaa atttaaaaaa 58561 aatagattcc agattaggag ttatgactag tactgacata cgtaggctat tcatttattt 58621 tagcccatca gagcctgaag aactgatttt tctttttttg gcctctggtt cagaaagata 58681 aaattaagag agaaaaagag atactaagac tgcttgacta tcatggtctt aagttagtcc 58741 catggcttgg aaaagttaaa cagggaaaca agatgagaaa tccattgaga tttctagagc 58801 tttattgttt tatggtctcc cttacaaatc accagagcct cagaaacacc catttcaagc 58861 atagaataaa aaaacctctc tcaacccaag caggtactgg gttggcaata tacattggct 58921 gagagaacaa attgtattaa aaacaaaaac aaaaaaaaaa ctttccctga agttttgaaa 58981 atgtaagttg aatcaaaaaa cagaagcaat gagggatgag ttacagaacg ttctgtgcat 59041 tctcagaggg atttaccatt gcaggctgga ataggagcac tccattctcc agaggacata 59101 cactgcatgg tctccatgct gcttggcagg taacccctat cacagctgat agagcaggaa 59161 gaattgtagc tgaagtttcc cagtgggtga ctgcaaacca ggcttccatg ctcaggggat 59221 tccagggctg tacagttcac aactgaaaaa gaaacccaaa tcagttctgc tcatctctca 59281 cctttaacag ataagaacac tggaaactag aactacagtt tggttttttt tttttttagt 59341 ttaaaaattt ataaaatttc taatggaatt tgtaaaattg actgtaattc tacccctttt 59401 cttttattca agaaaatgct gatccataac aacaacaaca aaaaagcagt gatgacaacc EPI-109 930

59461 ataaaaaaga aatattgagt gatatgggga gagtagtgta attgtgttta cctcaaaact 59521 gttcaaatta tatgaacaaa cacagcaaac ttaggtacca caacaaattt cttgttactt 59581 ttctcacaac tgctaaaaat actacagtaa gcttccaacc aggatgagaa ccattcacaa 59641 agctatattt caaatttaag tactagaata cattacaaat tttaaaaccc taatgctgca 59701 ctgtctacta tagtagccac tatctgtgtg gctactcaaa tttaaacttg aattcgttga 59761 aatcaaataa catttaaaat tcagttcctc agtgtcacca gccacatttc aagtactcaa 59821 taaccacatg tggctcatag gtacacactg gaaaacacag ctatggaaca tttccattat 59881 cacaaaagct ctactgcaca acgctgtgct aaggaatctt ggagagaagc tcatctaact 59941 ctcttaatgt acaaatttag gaactgagac ctcatttcat tcaagtgact tgctccatgc 60001 tacacggcta gtcattacag agccagaggc cagagcatga accaagatac cctggactct 60061 gtaactcact catttctact gcaacgtctt gttaccacct agatgaggtg agtacatgtt 60121 cctcgcaggg acacagaatt acagtttatt gaatgtgtcc tgtgtgccag gcaccatgta 60181 accatgagcc tatgaagttc acactattat tatcctcatt ttacaatgag aaaactgaca 60241 tagagagtta aactatcttg tcaaggtgcc aaaataaata actggtgaat ctaggactca 60301 aacccagcag ggtctgactt catagtctca gctcacgatc accatatgac accatctgca 60361 ccagggaagg gaaggcatgc agacctgact ctaatgccag ctaggacgtg agatggtgct 60421 accatctcaa gtgaagaaag aggcaagaac cagacttact ttgctcacac ttgagtccac 60481 tgaagccagg gtcacacttg caagtgtaat tattgatggt ctctacacat tcaccgtggc 60541 cactgcagga tgtattggta caggcagcta cggaaaatac aaagcatgat gaggaggact 60601 attactgtgc ttatactgag tgcctttgat tttagaatca acagtgtgca acagagacat 60661 cagcagtcct acagagtgcc atagacttta actgaagtgt tttacaaagt tccaaatctg 60721 agtttcaggc ccacctatcc taaaccttga tgctaatgta tagctgtggc tggcacctac 60781 cgtagaaaat ttacttcttc acaaactctg aagacagttc ccctaccaca aataaacaag 60841 taattaaaat atgtattgtg tgtgtgcatt tttatatgta aagaactaca tatttgccta 60901 cagtatttat atatatttta tatatataca tacacacata tatgtgtgta tatgtgtgta 60961 tgtatatata taaaatgtat ataaatgctg taggctatat atatatacac acacacatat 61021 atgtgtgtgt gtatatatgt gtgtgtgtgt atatatatac atatccacat attcttgccc 61081 acattcacac aaaacagcaa aagagagaaa ctttagcagt taaacagaat cttttggaac 61141 ataaaatgac cacaatagag agcagttttt gcatgctgta aatttgccaa gatgcccaca 61201 cactgaaact acctcccact gctgccgcaa actccctacc tgtgtagcat agggcaagct 61261 tcttcttgct gcacctctca tcattccaca tgcccacatc tttttctctc ttgatgtaga 61321 tctccacgca gtcctcatct ttttgcctat tgttgggttc acctggagcc cagttcttgg 61381 cttcttctgt cagaggtttc tgggttccta cccagaccca cacattgttg acttttctga 61441 ttccaatcca gtaataactt ggtgaatagc tcaatatgga gtttaggtac tcaatctctt 61501 ctttgttttg aattgcaacc aggtgtgtgt acctttgctg acaataagca ctggcctcat 61561 cataagtcat agcttccgtg gaggtgttgt aagaccaggc tccactctct ttaatgagaa 61621 gcactagtgg gagaaaaaga aaagaaatgg tagagtttgg tactgttgtg gtttaactct 61681 gacaactgtg ctttttattg tcttattttt ggcaatgttt gtgacatggc ccagactttt 61741 ctcatctttt caaaagtaag aagtacgtat gaagaaacag cgacttattg tttatctctt 61801 ttgtgactgc cacccactag gtaccttatc cacactcact cacaacatta tagtataccc 61861 attttgtagt agaataataa tcagaataac taagctttat tgagcactta gtatgcacca 61921 agaagcactg tatgaggtac tttccatgaa ccatgctatt gaatcctcac aatgcatctg 61981 ggaaataggt cattatgatc cacactttac acttaaggaa agggagacac caagaggtaa 62041 agtaaatgac cccaagccca gggaagaaca cattgcaggt agaggtcaag gatgctgcca 62101 gatatcctgt gcaggacagc cccagacaag caaggatatt tcagtctgaa atatctatag 62161 tgcgagaatg agaaatcttg gtctaatggc actgacttac ccaaagtgag agctgagaga 62221 aactgtgaag caatcatgac ttcaagagtt cttttcaccc aaaggtttag gcttgaaata 62281 ctttcctggg gagataaaac acaaaatgaa ttaaagaagg aaatcgtggg tagctagtta 62341 cattattcta ccatgatgtt taaggcagca tcctaagatt ttgggcaaag gacactagtg 62401 caataatctt tatttcagag tttaatcaaa taaataaaca aattttaaga ctttcattat 62461 ttaggtcaaa gagaaaagac aggttttagc tacaatacaa taagagcttg tacagatgtg 62521 gtttttatta gaaggccttt tgcatatctg tgtttcatgg cccgaggctg cccttataaa 62581 gcgttctgca cttaccgttt tgggaagcag ttgttcaaac acaggatctc tcaggtgggt 62641 atcactgctg cctctgtctc aggtcagtat aggagttttg atgtgaagtc agccaagaac 62701 agctgaacac tacttcggct gaggcccttt tataggaggg attgcttcct gtgaataata 62761 ggaggatatt gtccacatcc agtaaagagg aaatccccaa tggcatccaa aaactttccc 62821 gggaatatcc acgatgctta aaattacaat gatgtcagaa actctgtctc ttgaagctac 62881 ttcacctttg tccatgcctt tatatcgtat atgcaatttt attaatatga caaaaatgca 62941 tgatttttaa ttataataac ataaagtcta tgtctttaaa aagttgtaaa actttgcttg 63001 ttagtagtgt ctctcatgta gttgtggtag taattagaat ttcagaaaca gaaggaaacc 63061 aagaataggt ttgtcatcca tagtctacta ccttcaattt ctcattcata gctgtggata 63121 accaatcact actcattttt tcttcctttt tcacctgcca attcaacata tttaacatgc 63181 actgtctcac agaggaatga ctcacaaggt agatattaat cttcagattt tgcacggcag 63241 ttatgcctaa attaaaatat tatctaaaaa taatatctaa cactcaaatg gttaaaataa 63301 tgccttattt taaaaaaaga aaaatgggaa atagatattt acatctggga aagtttcatg 63361 gtttgttcag tgaaaaaaat aaaaaggagg ccaggcacag tggctcacgc ctgtaatccc 63421 accactttgg gaggccgagg caggcggatc acctgaggcc gggagttcaa gaccagcctg 63481 accaacatgg agaaacgcca tctctactaa aaatacaaaa ttagctgggc atggtggcgc 63541 atgcctgtaa tcccagctac tcgggaggct gaggcaggag aatcgcttga acccgggaag 63601 tggaggttgc agtgagccaa gatcacgcca gtgcactcca gcctgggaaa cgagtgaaac 63661 tctgtcttaa aaaaaaaaaa aaaaaaagaa aagaaaagaa aaaaaataaa acggaaaact 63721 atatatatat atttaattgg tcaaaatttt gtttaaaatt tttgaaatgt taatgtgcaa 63781 agaataaaaa ttcttccaca atgttaacag tgactaactc tggatggcag gatttgggat 63841 aatttttata tccttcatta ttattttcag gattttaaag tttttttcaa tttccctttt 63901 tttcaccttt atagtaacaa gaatacagtt taaagaaact tgtctctagg ccaggcatga EPI-109 931

63961 tggctcatgc ctgtaatccc agcactttgg gaggctgagg tgggtggatc acctgaggtc 64021 aggagttcca gaccagcgtg gccaatatgg tgaaaccctg tctctactaa aaatacaaaa 64081 attagccggg gtgtagtggc gcatgcctgt aatcccagct actggggagc ctgatgcaag 64141 agaatcgctt gaacccagga ggcagaggtt gcagtgagct gaaatcacac cattgcactc 64201 cagcctgggc gacagagcaa gactccatct caaaaaaaaa gaaaaaaaga aaaagaaaag 64261 aaaagaaatt tgtttccaaa tgcaacagaa ggagatgtat gtggtatcct atattcctgc 64321 tcttcatttt gacatttctt ctgggtgatt gtatacattc cccatctctg catcttaccc 64381 tatctaaatg atggtaacag taaatgggga tcattttaat ttccatattc tgtaggtttt 64441 cagagctcaa gtcaagctaa tattctatat ctacagcctt tcaaaatagg aggtctatct 64501 aaaaatgtac tgtcagcaga cctgaacgag tagtggtaaa agcctcgttt ttctctttac 64561 ttgttagcac tggtctttct gtgttcataa agatgtcaag acccaaaaaa aaaacaagaa 64621 aagagaagaa aaattccaaa aaagacaact gattagaaaa aaataactta attaacgaat 64681 ttaattcaac ccctatcaaa aagcatagaa tttattccct ccaccttacc actctcttac 64741 atgatccaga tactgacatt attccaattc tttatcccac tttacttagc tcaatgtggt 64801 tgttgcttca ataaattcag aagagtaatc actcatatag tgtttattta gattttaggg 64861 cagaatgtca agttgggtta atacattatc tgtatgtatt ttatttttaa taaagtatga 64921 atacataatc tgctattttt aaaaagcatg gtcaaatgta tagagtagcc aaatcttaaa 64981 aaacaattta tcttcgatat caataaagta cctaataatt atattgctaa tagaaattag 65041 tcgttaacat ccctagataa ctaactttat tattgcgaat ttttcataac taagtttata 65101 gtttatctct tccccttttt aaaattagtt caaagatatc taaaaatagc cccagtggtg 65161 atgaagtttc tattttactt acatatatat gtcctggacc cccaattata atctctaaca 65221 tttattgagt gcttactatg tgccaggcca tattctgagc attttgtatg ttcacctatt 65281 gattattcaa tccgtacaac agcctatgaa ataggtactc ctattatccc cattttacag 65341 atgaggaaat tgagaatctg gggattttat ctcattcaaa agcacagagc taagggttga 65401 aaccaggcag ttgatatcca gagcccactc ccttacctgc tactccaaac catgatttct 65461 tttgttgtta tgccccgaga ttccttgttc tacccaagtt tcctgtactc ttcttgccct 65521 cttcttcctg agacatcctt gaccatcaca gctctccact gagataactg tgtcctgggt 65581 tctgagacat gggggctgga agggacccca gggacagtga gcagtaggga gaggatgcag 65641 tgagaacaga ccctggatcc ccggtgcata ggcagggaga aagtggacaa aggaaaaaac 65701 aagcaaggca ggtggagcca tgcctaggta aagttgatcc ctaagccaca gttcccagaa 65761 gttcctgatt caaaagcaaa ttttctctaa ggtcaaaggg caaactgatt attctaaatt 65821 ctaaactgat tatttctaaa ttgagaaagc ttcagggaga gatcccaata ttcgaaggat 65881 aagagaaatg aggagtggaa gagataggtg agtaacagta acttaaatgt agactatata 65941 taatatataa tatatgtaga gtatatatat ataattacaa tatattatat atgtggaata 66001 tatatattat ttatatatat ttatatattt tatatatata gatattttta tattttatat 66061 ataaatatag atatttttat attttatata taaatataga tatttttata tatattatat 66121 ataaatatat gtaaaatact gtgaaagaag aatagaatct tgagacctca aattcactat 66181 gccaaaggga aagttaagct tgggaaatga gtcatgcaaa aactgccttc cttttgttcc 66241 caaatacctg taatttcaca tgcttacttt atcttatata aaatgtagat gtactgagca 66301 tgagatccat gcataatttc cctctagtcc cttcttttta catgtaaagt gtagactcac 66361 tgagtgttac agagccttgc cacaatgtaa acacttgtct cattgccaac ccatctttcg 66421 tttattttct tcccctcctg cttgctcttt cccctctaaa gatggaagtt cccaaaactc 66481 tctttggaaa aagcgcaggt cacagatcct acagtgattt gtgtttcttt tacctgggac 66541 aaaataaacc tctaatctgt tgagatatgc ttcagttact ttttggttta caatatgtac 66601 atgtatgtat ataatttata tgtatataat atatgtactt gttttaacca gaggtatgtt 66661 attcaaaatc cattcatcct tacaattacc tgcattctcc cacagtattt tctgtgtccc 66721 tgcccccgag gttgtcactg caaatcaggt acatggatac tgggagctga tgggctcccc 66781 tctggctacc tgggctgctg aaggggccat agacagaccc agctttcctc tcgtggagag 66841 gccctgggcc agcgctgcgt gggagtggga ttacaaccag actatagctt cttcacctgc 66901 tttttcctat caggatttca taagaggcaa ttgcttgttt tttgagggtg ggggcaaatc 66961 agggggagtt gaagaggaaa ttgggtaaga tttgaatagt tgggcatgtt gaatattatg 67021 aatatcatct ccctcttcaa ataatccaaa atataccccc aagaaacagg ctgattagag 67081 gtgcttcaag gctccactga atctcccaag ctctgaagat gtagctagct gttaccggat 67141 tgccggtttt caagcctcgc ctcacatgga ccctcttggc agtttctcgc atgggggaag 67201 catccgctac atagatggga atgaaaagag gaaagaagac ggtgcaaact caggcacacc 67261 ccggtgtctg ccaccagtgc tatttaatct ctgaggtgtc acccttcctg gctttattgt 67321 ctcttcctgg aagtctcttg tcctctcctc cacacccttt aatcaggcat caaagacttt 67381 aaccagtttt gctgtgtgcc caggcccact cattctcact tttatggcaa agggagtggg 67441 agacagagag atagccagaa agaagagatt ggggacccca agacaaatgt tagaatttta 67501 accaaggcca ccctgtggac aggagattat tgggtttagt ggaaagcagc actggccaca 67561 accacacgtg gcaaaagcat ctatcgagga gtgaagttat atttggtgaa tgtgaccggg 67621 aagcaggggc agtggtgtcc tcctgccttc ctgaggcact ctgttccctt acctctgcga 67681 aggcttattt tacccctgag tgcttagttt tgaaagcctt agttccctct ctcccataaa 67741 aaagctctac tctgctaaca tctaagttac ctttgcagag tcttaggtag agggaggaaa 67801 tcccaataaa gattccaccc tatctgcaaa atacaaacat ggtatttctt gcattcccaa 67861 aattgtgaaa gaaaatgtgt atcaccacag tagagaatgg cattttttgt ttgatcaaaa 67921 cctaaatata tttgatgaaa atgtgtctgg ttctaagttt atttcccaga aagccatgtt 67981 tactcacttg gaatttatag acatcttata atatctgagt cgagtaggag ctccgggctc 68041 tacctcactc ttttctccca cacccagggg gaagtgtagg gttctcagac tttagaataa 68101 agaggaatca cctggacaac tcacctaaaa tgcacatctt caggtctcat actcagaggc 68161 tctgactcaa caggtctggg tggcgcccaa gaatttgggc tttaaatgag tatctcagat 68221 gattctaata cagaatgtgt aagatgacca gatcctatca cacttagatg tattggccta 68281 gggccaccta acttggagaa aatgttagta agaccccgtg gttggtgctc agctataggt 68341 accagaattt tgatcaaaat ttactatcat tgtgacactt ctcttcggaa ctggaaggcc 68401 agaaccccac ttgtaaagtg ctgggaaaat acaaggaaaa tttagggtga gtagcatttt EPI-109 9₃2

68461 gaattcttac acatggaaag taaatgtata agaattctta ccaataaaaa aaaagcaaga 68521 gagaatagct gctaaagaat taacacaaat atgtatatat tagttattct cttttctcct 68581 ctgattccag aggactttgt aattccacta attcttcttg agcttccagg atgatctgag 68641 acttgaattt ttcatgtgct ttttgcttcc tatttggcag catcttatct tgaagtttcc 68701 gctttctgct tggggaccta aaaactaact aatgggaatt tcttcaaaat gagcaaactc 68761 tggtgaattc ccaaagcgga agaaacaagt gaggatcggg ctggttaatt aagagaactt 68821 ttcctgaatg tagccagact gtttgccgac tgttgttaac atgagggaag aaatacccct 68881 ggattttaga agagcccctt gtttgttttc cttggccatt tgtgctgctt gttttgtaag 68941 tcagaaattt cctgaaggac tattattagc tttgttctca cgtcagaaaa cttctgctct 69001 ggccactttt aaacatataa cttggatttt actgtattag aaaatgtaac aattacagac 69061 agcactaaaa ggacaccaaa gggcaaagaa aatgggtaac ttttttttct tccccaaatc 69121 taaaataggt gattttggag aagtaggaga aaaacctgga ttttctagat ctctttagag 69181 ctcaacaact gatatagtta attatgtaag tctttgatat ttggaaatga ttggattaac 69241 cggataacaa tgaatattta aatacagtga tttggccagg agcagtggct catgcctgta 69301 atcccagcat ttggggaggc tgaggcgggt ggatcaccta aggccgggag ttccagacca 69361 gcctggccaa catggtgaaa ccccatctct actaaaaata caaaattagc caggcgtggt 69421 ggtgcaagac tgtaatccca gcaactcggg aggctgaggc aggagaattg cttgaacccg 69481 ggaggcagag gttgcagtga gccaagatca cgccattgca ctccagcctg ggcaacaaga 69541 gcgaaattcc atctcaataa ataaataaat aaatacagtg atttaacaca agagatttct 69601 atttcacact aatgagctct gtcactgggg caagcttctt tgcctcatta agtctcagat 69661 ttcccgagag cttatttatt tataccaaga gtgctttact accgtctctg ctagctgtga 69721 cataatatga caaaaggtat aaatatggga aaaggcacta atttatatca aagcgttctt 69781 cgtttttcct tgctgtgaag tttttagcta ataattcata agaatatacc atatttagag 69841 tgtttactat gcatgggcct ggcacttcac atacattgct tcttacaaat tttacaaagt 69901 gaaaggtaga tattaatctc attttatgga ggacaagata gagatctgga gaggttacat 69961 aacttgccag tgttttttca gttaataaat ggtagggtgg agattcaatc tgtgttactc 70021 taaagtccgt gtccttttta ttggctccat gcctactcag atttaaatct cagcagggaa 70081 gtaaacctta gtttttacat gagaaaatgt tacagcagcc ttctcggctt cctttacccc 70141 catcccagtt tcacgagctt agtgccttag atcgggttcc tttagaagca gacctcgaaa 70201 taaggatgtg ggtgccagtc atttattgaa aagatgatcc caagaaagcc tagtaggaga 70261 gtgaggaagt gagatgggga aaggaagaaa ctccacaaga agtgtgttaa taagcaggtt 70321 accgctgtgg gcagccatgg ggctcagctg cactaacaaa ctctgtctag tacagaaaac 70381 ctcagggtct ccccaaggag gggcaagaag tctgcctagg gtatatatcc gccaactcag 70441 tcactggctg agagctgatc ctgggagggc atggttaatt cctctgcact ttcaagtgga 70501 ttcctgtggt cagaaaaag^'c cctctacaat gaattccaga tgcttgtatt taaatctgac 70561 atgatctgaa tgctgtgttg ggacagggtg ggcgttatta gttttctgtc attactgtaa 70621 cagattacta caaacctgat ggctgcaaac aacacatatt tattatgtca tagtttgtgt 70681 gggtcagaag tacaggttag ctcaactagt ttctctgctc taggtttcac attgccaata 70741 tcaaggtgtc atccagttgg gctcttcttg ggaggcttgg ggatgaatcc actttcaagc 70801 tcattcagat tgttggcaga atccagttcc ttgtggttgc aggaccaagg tccctgttgc 70861 cttgctggct gttggccagg agtcattctt agcttctaga gactacctgt actctctgac 70921 tcgtgtctcc acttcacctt tcaaaccagc agcggctagt cgagtccctc tcttcaaatg 70981 tctccaactg tgccttcacc tcatttctcc tctgtgtacc atgtctgcct ctactgcttg 71041 taagggctca tgggattaca ttggatttat tcaatccagg ataatctcca tattttaagg 71101 ctagctgact agtgatctta attccatcta caaagtccct tccaatagta ctgtattagt 71161 ccattttcat gctactgata aagacatacc caagactggg caattcacaa aagaaagagg 71221 tttaattaga tttacagttc cacatggctg gggaagcctc acaatcatgg cagaagtcaa 71281 ggaagagcaa gtcatgtctt acatagatgg cagcaggcaa agagagagag cttgtgcagg 71341 gaactcctct ttttaaaacc atcagatctc ataatactta ttcactatca caagaacagc 71401 atgggaaagt cttgccccca tgattcaatt actcccacca ggtccctccc acaacatgca 71461 ggaattcaag atgagatttg tgtggggaca cagccaaacc atatcaagta cctagattca 71521 tgtttgatta aacaaccagg gagcagaaat cttcaggagt ggggggcatc tttagaattc 71581 tgcccaccaa ggctgggcgc ggtggctcac acctgtaatc ccagcacttt gggaggccaa 71641 ggtgggtgga tcatgaggtc aagagatcga gaccaccctg gccatggtga aaccccattt 71701 ctactaaaaa tacaaaaatt agccaggtat ggtggtgggc acctgtagtc ccagctactc 71761 aggaggctga ggtaggagaa tcacttgaac ccaggaagcg gaggttgcag tgagccaaga 71821 ttgcgccgct gcactccagc ctgggagaca gagcaagact gtctcaaaaa aaaagaattc 71881 tgcccatcat agtaggctgt cctacagaga cataacccag gaattaggtg aatggctaac 71941 ctaaattagc actgtgatgt gttttctgac ttggtcctta tagctcctct gcttagatgt 72001 ggaactaatc catgaatgca agggtttgtc tagagtttta agtgggagtt aaatatccaa 72061 agtacaggag atattatggg tgcctcatcc atgtcccctt ggcatttatc tttcttggat 72121 aacccaactc tattagtttt tatatctcac ttgttcctat actctgtgaa ctgatgtccc 72181 ataaatagac atttcatttt gccagtcttc ttgaacaata attacgatta ttaatctagc 72241 agttatcatt aattggccac ttcacattag acacagcact taggacttaa gaataccatg 72301 tcatttgatc atcataatat ggtcaggaat taagtattgc tatccaaatt ttacaaagaa 72361 ggcactgagg gttagagttt aaataacttg cttaagatgt catagcctgt aagtgacaaa 72421 actaggactc aaatacaggt ccatctgact ccaaagtcta tgttcttggc taccacactg 72481 cctctcctac aagtgacctg tggttttact actatattca cactctacta actttaccat 72541 ctcccatgag tctgtctaga ggagggcaca cacagcacag aaaacacatg aatgcaaaat 72601 aaggaagggc ctacttacta cacagagcca ttctaatacc tgatgtttgc tctaatccag 72661 ttttactatt aattagttgc tggtgcccaa gtttttactg agaaatgggg ataattttgg 72721 aagtcataat gatgccttct tctcataggg tattttattt gttgttgtat ctccaggccc 72781 caacacagcc tggcttttag taaatgatca aaaatacctg ttgaatgaat aaatggagtc 72841 acctgaaaca tgttaaacat ttgttcatgt gtcctaatcg tggatttcag gatagtaagc 72901 atcctaaaag gaaagcatgc acactgttct tgctacatta atttctcaca atataaaaaa EPI-109 933

72961 agaaaagcat ctgaaaaaag ctgccagccg ctgtgtctcc taatatcaaa ctgagcacag 73021 atatggagaa gctaagggag agggatgatg ggccatgcct ctaacctcat catggcaaaa 73081 gtcctggggg tcagacccga ggagagcagg aagtgtcttt tgagggatac atttccacag 73141 tggaaataat gagacttaaa taaatattat atacacagtt caactgtttt tatgtgtaaa 73201 ggtagtaggt tttcacagta aggaagcact tctttttttt tttgtttgag acagagtctc 73261 gctctgtctc ccagcctgga gtacagtggt gctatctcgg ctcactgcaa tctctgcctc 73321 ctggattcaa gtgattctcc tgcctcagcc tcccgagtag ctgggacaac aggtgtgtgc 73381 cattacacct ggctaatttt tgtattttta gcagagatgc ggtttcacca tgttggccag 73441 gctgatctcg aactcctgac ctcaggtgtt ctgcccgcct ctgcctccca atgtgctggg 73501 attacaggca tgagccactg cactcaccaa gcacttctac tgatagcatt tacaaaccct 73561 tcttagaata tttaaaaatt ctaagagaag agtaaattga gccttcccaa ctaatactag 73621 gaggttataa ccttcatacc aaaactggac aatgcttgca caaaagaagg aagccaatga 73681 ggccacctag aaggaagact gggcattggg cccagtgagt cctggaaacc tcatctgtgc 73741 cagccacccc ggcatggcct gtatgagtgg atgagggtga cttgtccaca gacaatagcc 73801 atctagctgt gataaaggag tcaaggtagt cagctgcatc tctttcacct gtttgccaat 73861 gttacacagg ttgaaaagct aaggtttatg taaagcaagc atcaaagatg atgaaatgat 73921 caacctgaca atgagtacta tgctgcattg tccagaaagg aactgtggaa gattttgggc 73981 tgaatttcaa aacagaattt cctcactctc tggatgttgg cttacttggc ctttgatgtt 74041 cagaggtggt gcctttgtgt tgttgaacaa tgttgatttt ggagagaaaa cagagttgaa 74101 aaacccacaa gtcattccct ggggagtatt accggaatac agaggataat ttcagcaagc 74161 cagcaaggcc tcatctctgc ttctaataga taggaagaaa ggaagagagg aacaatactt 74221 ttttaagaag ctcagcttta tcgccttatc tcatagaaag atgcctccag tctgtctggc 74281 taaaggtaat tggcatggga aagtctttat ctgtgattct aacaagtgga atgtttccct 74341 tcattaagag agccttgtct ggcttgggga aatgaaacac tttctccgat atgagtgggc 74401 tgtaacccct gctactaaat actcagaaga aataaggcgg ttgtggagca gtcaggaatg 74461 agtcacttgc ctccctggaa tattcagaaa actgaatcaa aagtacattc ttctgggttt 74521 tcttagtcta atagactaag ggtctctact ttgttaaatt tctgggaaac agcatagaat 74581 gggagaaaaa actggtcact gtagtcatgc aaatctgcaa aacaaacaaa aaagtctggg 74641 tattgctgct aactagctat gtgaccttaa gcaaggtatt aactctctct gaatttcagg 74701 ttcttcatct gttaaatagc atatctgtaa aatgggaatt attttcatat cataatgctg 74761 tagctttaaa aaataaaata aaatggatga gataatcaga attaaagagc ctgggatata 74821 tagttaatat atagcagcat gtaaagatcc tgttagaaat gctaatttta cagttaacca 74881 tttggagatg atccgccaaa gctgctagtg tagaggcaac tgagaatttg cctgtccttc 74941 agaatatgaa taaataactg tcaatgatgt ctcaagccta gaaaaaccta tccatctgga 75001 tgggtgggaa atttctaggc tagtattgag aagcccattt cttgggaaat aggtcctgga 75061 ctgagtgaag gaaaagaaac agtaaaaccc atggtaaagc agcaaggctc tctagaggct 75121 ctggagagga tgaattgaat tctagaagat gaagtaggga agacgcttta ccttcttgtg 75181 aaatggattc aaagattcaa agaccttcgg gaatctccaa ttgtataaat ggcaccatag 75241 ctgtatgttc catggaacac tacttcccag agatgcccag tgaaaaaaga atgccacagt 75301 caaataagtt tggaaacact ccattatgtg gccacctcct tgaagactct aatgcacatt 75361 agcatgttaa acagtcttga gaagtcctgc agagcagaaa ttgcttcaca tctgctaagc 75421 cggcagtttc ccaatatact tgattatgga tagttttttc cttacaacac cattctctga 75481 tatgcttcca atgacatgaa ataaatatat atgcatgagg ttcttcatta gggcatactt 75541 tttaatagaa aatattgaga ataatctaaa tataaatgca cagcatttac cttttctgca 75601 taaactatat acaggcatac cttggagata ctatgggttt ggttcccaca atatctccaa 75661 aaccacattc ggttttatga ccactgccat aaaaccagcc acatgaattt tttggtttcc 75721 caatgtatat caaagttaca tttttactat accatagtct attatatata caatagcatt 75781 atatctaaaa aacaacgtaa acaccttaat ttaaggctgt ggctggtttg attttctacc 75841 cagaccacta aaactttctt catatcagca ataaggctgt ttcactttct tactattttt 75901 tgtgatagca cttttccttt ccttcaagaa tttttccttt ctattcacaa tttgtttgat 75961 acaagaggac tagattttag cttatctcag tttaaggtgt ttacattgtt agctaaaaat 76021 gctaatgatc atctgagact tcagcaagtc ataatctttt gctggtggaa ggtcttgcct 76081 cagtgttgat gtctgctgac tgggtggctt tggcaatttc ttaaagtaag acaacaatca 76141 agtttgacat atcaattgac ccttcctgtc ataaatgatt ttttttttct ctgtagcctg 76201 caatgctctt tgatagcatt ttacccacag tagaattttc aaaattggag tcaatccttt 76261 caaactctgg tgctgtttta tcaactaagt ttatggagta ttagaaatcc cttgttgtca 76321 tttcaacaat gttcacacca tcttccccag gagtatattc tacctcaaga aaccactttc 76381 tttgctcatc tataagaagc agctcctcat ccactaaagt tttatcctga gattgcaaca 76441 attcagttac atcttcaggc tctacttcta attctagttc tcttgctgtt tctatctcat 76501 ttgtgcttac tttctccgct gaagtcttga accccttaaa gtcactcatg agggttggaa 76561 tcaacttctt acaaactcct gttgatgttg atattttgac ctgctcccat gattcatggg 76621 tattcttaat ggcatctaga atggtgaacg ttttcagaag gttttcagtt ggctttgccc 76681 ggatccatca gacgaatccc tatctatgga agctatagat ttataaaatg tatttctttt 76741 tttgtggggg catagcgtct caccctgtca cccaacctgg aatgcagtgg cacagtcata 76801 actcactgaa gactcaaact cctgggctca agtgattctt ccaccttggc ctcccaaaac 76861 actggattac aagcttgagc cactgtgtct agcccaaaat gtatatcata actaatgagg 76921 cttgaaagtc aaagtgactc cttgatccat gggctacaga atggacgctg ggttaccaga 76981 catgaaaaca atactcatct cctcatacat ctccttcaga gctcctgggt gagcaggccc 77041 attgtcaaat gagcagtagt atcttgaaag aaattttttt tctgagcagt agatctccac 77101 agtggactta aaatagtcag taaactatgc tgtaaacaga agtgctgtca tccaagctct 77161 gtttttccac tgatagggca aaagcagagt agatttggca taattctcta gggccttagg 77221 atttttggaa tggcaaattg agcattggct tcaacttttt tttttttttt tttttttgag 77281 acagagtctt ggtctgtcac ccaggctgga gtgcagtggt gcaatctcgg cccactgcaa 77341 gctctgcctc ctaggttcac accattctcc tgcctctgcc tcctgagtag ctgggactac 77401 aggcacccgc caccatgccc ggctaatttt ttgtatttta gtacagacgg ggtttcgcca EPI-109 934

77461 tgttagccag gatggtctcg atctcctgac ctcgtgatcc acccgcctcg gcctcccaaa 77521 gtgctgggat tacaggcgtg agccacagcg cccagcctgt cttcaactta aagtcgccag 77581 ctgtgttagc ctctaataag agagtctgcc tgtcctttca agctttgaag ccaggcatca 77641 ttctcttctc tagctatgaa aatcttagat agcatcttct cccaatagga agccattttt 77701 tatgccctaa aaatctgtcg tttggtgtag ccaccttcat cattgatctt acctagatcc 77761 gctggataac ttaccacagt gtctacatca ttacttctgc ttcaccttgc acttttatgt 77821 tatggggatg gctcctttcc tctaacctca taaactaacc tccactagcc tcacattctt 77881 cttttacagc ttcctcgcct ctctcagagt tcacagaatt gaagaatgtt gggccttgga 77941 ttacactttg gtttaaggga atgctgtggc tggtttgatt ttctatccag aacactaaaa 78001 ctttcttcat atcagcaata agactgtttc actttcttac tattttttgt gatagcactt 78061 ttcctttcct tcaagaattt ttcctttcta ttcacaattt gaccgtttga tatgagaggc 78121 ctagatttta gccaatctca gtttacacca tgcctttttc actaagcttc atcattttag 78181 ctttttattt aaagtaagat gtgtgaccct tcctttcatt tgaacactta catgatgatg 78241 cctggcttca aagcttgaaa ggacaggcag actctcttat taggggctaa cacagctggc 78301 gacttttaag ttgaagccaa tgctcaattt gccattagaa gccattgtag ggttaattaa 78361 tttgcctaat tttaatatta tggtgtctca gggaataagg aggcctgagt agagggaggg 78421 agatggggaa acagccagtc atcagagcac acacaacatt tatcaattaa gtttatcacc 78481 ttgagggcac aggtcatgat acttcaaaac aattacaata ataaaataaa aaatcattga 78541 tcgcagatca ccataacaga tataatgata atgaaaaatt tgaagtattg tgagaattac 78601 caaaacgtga cacacagaca caaagtgagc acatgtcatt ggaaaagtgg tgctgataga 78661 cttacttcat gcagggttgc cacaaatact caatctgtaa aaaattcaat tatctacata 78721 gtaccataaa aacaaggtat acctgtttat ataatcaaga ccaacagaac cctagagaaa 78781 atagctcact ccctagctcg gagacattct aaccaacata cacttacctt tctttttgct 78841 gtgtacagaa ttcaaatcc^'c tgtctcagca aaattgcaaa gtatcaaatg tcatgtccat 78901 ctaatactca aaactgcaaa tgttaagtct tgtaagccca gagaccactg tatatacaag 78961 tgttgctata agcattagtt cttctccaaa gaaaatagtc cacttggtag aaacaaacaa 79021 aaagaaaaaa aaagaaagaa aaaacatttt ttacaagaag attcagtctc ttacctacat 79081 aagcaaaaat atgagatgtt ctcttatcat ttttccatct atcttataat ctttggtgct 79141 gacttagaca ctcattttcc tttttgtacg tgaccatgta aaagttcaag tcaagaaaaa 79201 cttgttttga catttgtttt gctgagtgat gggtccctaa aagaaatttg gctttgcttt 79261 tgaaaagttc agcatgatat tgtgtgaatt tttcatggct aatgattttt agaacagttg 79321 tgatgtgttt aggtgtttta agaatatgaa gcattcagtg gtttaagttg gttgttataa 79381 aatgaaagaa tatgaaggaa agccttcttg tcttagaaca cactgattca caaataagca 79441 gcttctctca aaatgttgta attacaaaaa ttccaaggca aatataataa actccttgtc 79501 ggtgctatgt ctagaaactt aacagcccca aagaaagtcc tgacaaggca aaaaatatat 79561 atatatatac aaattgtgga agcagggtgt tgaaagaaga ataaagacta tataaggaca 79621 aactgtttaa aagggagggt atccttgaaa gcttgacact tgactctttt gacgaggctg 79681 agggaaaaca ctcagtttca tagattgctg gtacggatgt aaaatagtga catccctata 79741 gagaggaatt tggcaatatc tagcaaaagt gcttatgcat ttattctttg acctagtaat 79801 cccgcttcta ggattagtgg tgaagataca cctcaacaat aaaaatatat atacattagg 79861 ttattagtta tggtttaatt tttaatagca aaatatttaa aacaacctac atgaacaaat 79921 aggagactta ctgaataaac tatggtatat ctgtacaata aagtgcaatt cacttatgtt 79981 gttaatttgt tccaaaaatc cagagccaaa gagtatttgt tatgctctct ttagtataag 80041 aaaggggaaa taagatatgt gtgcatctgt ttatttttgt gaaaataagt acagaaagga 80101 taagtaagaa actagtaaaa ctagttatct cctagtgtta gtagaaatag aatgaaagtg 80161 aattaggctt ctttgagtat atgtttatat atagttttga cttttgaatt atgtttatgt 80221 ttacatagtc aaaaatataa attaatcaac agaaataaca aaaaaagaag aaatcacaag 80281 ctttaaaatt taatacaaac agaaataatt gaatctaaca gtatatcaaa gtgataacgt 80341 aaactcagaa gaaaaaaaca taatccaaca taccagtgga acacaatatt ctaactgtat 80401 acattcagtg gttatagtct aaggacaaga aaaattgcaa aaatatcttg aactttagct 80461 tgtaggattt ttattggtag caatactaat gtactaattc tgaaattaat gttcgtgtat 80521 tatagaattg agtaaatgaa taaatatgtt gatgttattg ggaactaaaa ttatcattct 80581 gggagtagag aaatataaat atggacttgg caaatgaaac aaagacctgc agagagataa 80641 ccatataaac tcattatttt aaaaattata agtgtcctag ctctgttact gaaaaggcct 80701 agattcaatc ttatcttgat agacaggagg gcaccccttt ctcagaacat ggtttccaaa 80761 tgccattctc cattaaaagg aacaaggtct tcttggagaa aagactgatt ctaggtctgg 80821 attaggtaaa gtacaacgtt agtctggaat ttcttgctga atcagaagta agaaagtgct 80881 caaaaacatg ggaacatgtc acaaacacac gtgaggcaac ttgaatcctc actggccata 80941 tttaggacaa tcgagcatca aaaaaaaaaa aaatgttgag aataatggat tctaacactt 81001 aaaacaaaaa ataatccata gcccacagaa ggggaagaga gggggagctc ttatttacag 81061 atgaatatca aatagcaaag acagaagaaa tgacagaatt agagaaacat cattttgcaa 81121 aacaccactg taataatcaa ttcaggcaag tattattaat ggatgtatta ctattgcgta 81181 aaaccagttg gggaacagga tattcataca gtctgaaggt gtcaccctaa acataactta 81241 ttacaagtgg aaaatggtgc ctttacaatg aagaaatcta gcagaaacca tcttaatcta 81301 gtgatcaaac ttagtatcac caataatgga tcatactgag tcatgtgtct cctaatatga 81361 tgcaccagga aggatgcaac gtcatgaacg ttgtattctt ttgtattcaa cagaccaccc 81421 agggtaaagg cagctttctc acttactaat cagaattgtt ggttttaatt cattttggat 81481 tttaagattt cttactttct tgtcagctca gaaatttatt taagatgatt tttatctttt 81541 attcaatact ttagcttgga gaaccattca gagtttctaa ctcattgtat tgccaaaaat 81601 agaaaacagc atggtttctt ttgaaaatgt ctaactttaa agttacttgt gtgtgtcact 81661 cagattcaca tagctttttt gcctagtaat gtagtatcat gtggcaaggc tataaaaatg 81721 tttacaatct tttatttaat atgactcttg agagtttatt ctaaggaaat aattgaatag 81781 taacaaaaca ctattaacac aaagcatagc aatttgattt gggcaaccaa acactggaaa 81841 caacctaaat gtccattaca ggaatcattt atgaagcaaa cactaaaata tttattgtga 81901 agattatgag aacatagaag acagttatga gagtaaattt gaaaacctga acacaaaact EPI-109 935

81961 tacatatact ccaattgtaa cttataaaaa atacgtgcat ataaggataa aacagtacaa

82021 acaaaaaaat agttgcgtta gattggtaga attatggctc cttttgctgt cttaattttt

82081 tccttttaca ttttgataca ttattttaat tttaatttta aaattcaaaa gaatttgcca

82141 ctcatctttg ccacttcaag gaaaaaagaa atgtgttcga ttattctgtt cttagtatag

82201 ttttggcaat ttcctcacgt gtaaaaagag aatactatta ataatttcag tatctataag

82261 acaatataaa attaaagaat ctagcccagt aactggtaca tggaacgtaa ttaataaatc

82321 attatggact ttttttctca cacccaagta gggaggaatc agtggtcccc tagaggccca

82381 gtgtagaggt ggcagcacca atccctaggg gagaagatct tggtgatgat aattcctgag

82441 cagacagtta gctgagaatt caagagcaga aaagtaagaa agaaacaact tcttgctaac

82501 acctttccac ccacgtttcc ctgttctgtt gtactctgct taccctttca tggatggagg

82561 cagaggaaag agaaccaagt ttgctcttag tcattcacta tgttgtttaa tctgccttcc

82621 atctttctta tcagttcaaa ttagaatgta gacctgaatt taaatccccg ttctgtcagt

82681 tataatgtga ccctagacaa aacacattct ctgaacctca gagaacattc ttcatttgta

82741 gaatgggaag attaatctat attccacttg gatggcaagt cttttataaa ctttataacc

82801 taaacatgtg tgagttgcta gtatcattat gttggtaaag ttattctgag atatgataac

82861 agaactgttt tgtctaactc cactagcatg gttcaggttt agagagtgtg gaattaaaag

82921 gctttatcct caaatatgac ttaaatccga tttttctcat ccactttcct ccacaaacaa

82981 atcctcagga aatgacaaac tttacatggt taaacatcag ttttgtttag tctttgacat

83041 ccacatggtt aaatcataca tttgaaaact gcttatattt gtgttgtcta tgtctaaatt

83101 gaaaagactt attgaggaat agaagactac acatttttca gcaaacactg cacgttttgc

83161 agaatttccc caggcaccag tctccaggaa tttattggct actaacaata ctaagatatg

83221 gatgaatgag gaaatcaaaa tggagatctt gcaagttttg tgagaatggg tgaatggtcc

83281 aaatgaagag ataagttgtg aaatattagt acaagtaaaa attatttaca atgaaagaca

83341 ttttgtcaat agctatgaga attttaccat tgacccagaa attccatttc tttcttcaga

83401 aatacccacg taggtataca tataaaaagt tattcattac agtatcgttt ttcataggaa

83461 aaagttttaa aaatcagaag ctatctaaac tatggtatat ctaggtcata gaaatcaaat

83521 gactaaaaat gttaatataa gcatatgttt ttaaattaac ttggcttggg tcttcagcaa

83581 aattggcttc ttaacattgc actccagagt tagacttacc cactcagtca cttatcatgc

83641 aggagcagac tcctaatacc acatatcata gagcagagta ggacacaggt tctctgcagg

83701 caggcaaatc ccaaagagaa gggaggaaag ggctgagaca ctgcatggtc aatttcttct

83761 gaactctgca atgtacggag gtggacagtg tccacaaaga ttgctcccct ggacccacca

83821 tcataataac acaacggctt tgttttgttt ttgtttttgt tttttgacac ggagttttgc

83881 tcttgttgtc caggctggag tgcaatggtg tgatctcgac tcaccacaac ctccacttcc

83941 tgggttcaag tgattctcct gcctcagcct cctgagtgga tgggattaca ggcatgcacc

84001 accatgccca gctaattttg tatttttagt agagacgagg tttctccacg ttggccaggc

84061 tggtctcaaa ctcttaacct caggtgatcc acccgtcttg gcctcccaaa gtgctgcgat

84121 tacaggtgtg agccaccgcg cccagcccac aatggccttt tgtttacatc tctagtgcag

84181 cactcatttc atgttctttc aagaagaata catatttcat ctttttattt tatacagcaa

84241 ttagcacagt gcctggcata aggaaaatga tcattaaaag ctgggtgaaa aacctaataa

84301 agctactgag gataggaact gcagaccagc atggaaagaa aactatgagc cagatattga

84361 catcatcctg aaaggcagaa gatttagtat aggcaagaag tatgcttttg gaatatagaa

84421 aatctggatt atgataagaa aagaatcata tttgtcttat cttacctact cacttctcag

84481 ttccacatgt ttctgaggct gtttgtcctt actttctttt ctgttttatc cactctttct

84541 gttctttaga ttggatcatt cctattgagc tgacatcaag ttaactgacc ttttattttg

84601 tccaaactgc tgttaaatgc atccagtgaa tttttaactt tatatagtat atcttttagt

84661 cctagaattt ccacatgagt tttttaagtt tccatttctc tgctgagatc tcctatttgt

84721 tcattcatta tgaccatatt tttctctaca ttattgagca taattataac agctcttcta

84781 aaattcttgt ctgcacattc taacacctga attattctgg ggtcagtctc tgttacattg

84841 ccttattaca aaaacagtat aagtcacatt gccttgtttc ttaatatgca aaatgatttt

84901 tgattgcaga ctagacattt tgaattaaac attatagaga ttctggattc tcgagagagt

84961 attgacttgt tttttccatc aggcaggtaa cttgactgga ctcaaactcc aaactctagg

85021 tcctctgtaa tgggcaactg cagtaatctt tgtttagttc tttaagactt attggccagg

85081 cacgggggct catgcctgca atcccagcac tgtgggaggc caaggtggga ggatcacctg

85141 aggtcaggag ttcgagacca gcctggccca catggtgaaa ccctgcctct actaaaaata

85201 caaaaattag ccgggtgtgg tggtgggcgc ctgtagtccc agctactcag aaggctaagg

85261 cagaagaatc acttgaacct ggaaggcaga ggttgcagtg agccgagatt gtgccactat

85321 actccagcct gggtgacaaa agcgagactc cctctcaaaa aaaaatttat tggcactgct

85381 tggcatctgc tatgaataca tgaagttcat gggtcagcta tagatctggg cacgttatac

85441 acagaatttg ggtctccctt tctctggatt tctccttttc tggatttctt ttctcatttt

85501 ccagcagctg tggttgccct aaactcggtc ctctgtttct ttacggcagt aagatttggg

85561 aacttttagg ttttacctg^'c ctctcagaca aaataaaaaa taattttcat cttgatgcta

85621 ctcctttctt ccagatgtag acacctctct aatttccagt tgctttttat tgctctccag

85681 agtctaaaga ttatcattgt tttctgtggg agagttggtc tgataaaaac tactccccca

85741 aaactggaag ctggaagctt gtaattatga atagactttg agtagtattc ttctttggaa

85801 aaggatttta actactccct atgtacttct ttatttcctg tttttctcat ccgtaatctt

85861 tttattttca tacttcctaa gtcagacaat tttcctactt gaagattcag tgactgctat

85921 caaatgaccc ccatattact aaatacaata tccccaactg catttataaa aagaaaattt

85981 actgtttatt agtaaacaat gttgtagaat agtaaaatat tgctgggctt tggagccaga

86041 taatcaaggt tagaatccca gattctaact tactagctgg tgtattagtc ctttctcatg

86101 ctgctaataa agacataccc cagactggga gactgggtaa tttatgaaga aaagaggttt

86161 aattgactca cagttcagca tggctgggga ggccttagga aacttacagt catggtggca

86221 gcaaggagaa gttccaagca aagagggaaa agccccttat aaaaccatct gatcttatga

86281 gaactcactc actatcacga gaacagcatg agggtaactg ccctcacgtt taattacctt

86341 ccaccagttc ccccccatga cacatgggga ttatgaaagc tataattcaa gatgagattt

86401 gggtggagaa atagccaaac catataattc cacccctggc ccctctcaaa tctcatgtcc EPI-109 936

86461 tcacatttca aaactcaatc atgccctccc aactgtcccc caaggtctta actcattcca 86521 gcattaagtc aaaaatccaa gttcaaagtc tcatctgaga caaggcaagt cccttctgcc 86581 tatgagccta taaaatcaaa agcatgttag ttacttccta gatacagtgg gggtacaggc 86641 gttgggtaaa tacactgatt ccaaatggga gaaattgcca aaacaaaaga gttacagacc 86701 ccatgcaagt ccaaaaccca atagggcagt cattaacatt aaagttccaa aatgatctcc 86761 tttgacttca tgtctcacat ccaggtcaca ctgatgcaag aggtgggctt ccaatggcct 86821 tgggcagctc tgcccctgtg gctttgcagg gtatagcctg cttcctgttt gctttttcac 86881 aggctgacat tgagtgtctg tggcttttcc atgagtatgg tgcaagctgt tggtggattt 86941 accattctgg ggtctgggcc aggtgcagtg gctcatgcct gtaatcccag cactttggga 87001 ggctgaggtg ggggatcaca aggtcaggag atcgagacca tcctggctaa cacggtaaaa 87061 cccagtctct gcttaaaaaa tacaaaaaat tagccaggcg tggtggtggg tgcctgtagt 87121 cccagatact tgggaggctg aggcaggaga atggcgtgaa cccaggaggt ggagcttgca 87181 gcgagctgag attgtgccac tgcactccag cctgggcgac agagcaagac tccatcaaaa 87241 aaaaaaacaa aaaaaccatt ctggggtctg gagaatggta gcccttacag caccaccagg 87301 cagtgcccca gtggggactc tgtgtggggg ctctgacccc acatttccct tctgcacggc 87361 cctagtagag gttctccatg agggttctac ccctgcagca aacttctgcc tggacatcca 87421 ggcatttcca tacatcctcg gaaatctaag ccgcggaggt tcccaaactt caattcttga 87481 ctcctgtgca cccacaggct caataccaca tgtaagccac caatgcttgg tcagggcttg 87541 aaccctctga agcaatggcc tgagctgtac gttgacacct tttagcctag acatctagga 87601 cacagggcac catgacccga agcttcataa agtgggaggg ccttgggact agctgaggaa 87661 accatttttc catcctaggc ctccaggcct gtgatgggaa gggcagccat gaaggtgcct 87721 gacatgccct ggagacgttt tccccattgt cttggtaact aacattcagc tccgtgtgca 87781 gcaccaactt acttatgcaa atttctgtca ctggtttgaa tttctcccca gaaaacagga 87841 tttttctttt ctattgcatc atcatgctgc aaattttcaa acttttatgc tatgcttcct 87901 gttgaagact ttgcggctta gaaatttctt cccccagata cccaaaatta tctctctcaa 87961 gttcaaagtt ccacagatat ctaggggaca aaatgttgcc agtctctttg catagcaaga 88021 gtgaccttta ctccagttcc caacaagttt ctcatctcca tatgagacca tctcagcttg 88081 gacttagttg tccatgttac tatcaacatt ttggtcaaag ccattcaaca agtctctatg 88141 aagtttcaaa cttccccatg ttttcctgtc ttctaatagc cctccaaatt tttccaacct 88201 ctgtctgtta cccagttcta aagtcacttc tacatttttg ggtatcttta cagcagtggc 88261 actccccatg gtactaattt actgtattag tctgttctca tgctgctaat aaagacttac 88321 tcgagactgg gtaatttata aagaacagag gttcaactgg ctcacagttc agcatggctg 88381 ggaggcctca ggaaacttac aaacatggtg gcagcaaaga gaagttccaa gcaaagaggg 88441 aaaagcccct tataaaacca tcagatcttg tgagaattca ctatcatgaa aatagcatga 88501 gggtaactgc ccccatgatt aatttacctc ccacagggtc cctcccatga caggtgggga 88561 ttatgggaac tacaattcaa gatgagattt gggtggggac acagccatac catgccagct 88621 agagagcctt aagaaagtca cctaatctcc acaaataaaa ggtttcctat ttgttcaaca 88681 aaaataatga cacccctttt atgggatttc tgtgaggaca aatgataact aacatagcct 88741 tgcatagtgt ctggcacaaa atagctactc aaaaaataat agaaacaaca tttaaaaaat 88801 gtagacttta ttttttagag ttttatgtac aaagcaaaat tgagcagaat gtacagagag 88861 tttccgtata gcactcccta cccccaagca cagatagcct cccccagtat cagcatcccg 88921 caccagagtg gtacatttat tataactgat gaatctatat tgacgtgtca ttttcatcca 88981 aaatccatag tttatattag ggatgcctct tggtgttgta ccttctatgg gttttgacaa 89041 atgtataatg acatgtattc accattacag tatcataaag aatagtttca ctgtcctaaa 89101 aatctttgat cttcttccta ttcatcactc cctccccatt aatccctgac aactactgct 89161 aattttcctg tctccattgt tttgtctttt cctgaatgtc atatagttta aatatacagt 89221 atgtaggatt ttcaaactgg tttatttcac ttagtaatat gcatttgatg ttcttccata 89281 tcttttcaaa gcttcatagt tcaatattta tagaattgaa taatattcca ttgtctggat 89341 gtactacagt ttatgtattc attcacctat caaagaacac cttggttgct tccaagtttc 89401 aacaatcatg agtaaagctg ctataaacat ctatgtacat gtttttttgt gaattgaaca 89461 ttttcagctt ttttagctcc attcctagga gtgcaattgc tggattgtat gataagggta 89521 tgtttagtgt tgtaagaaac tgccacgctc ttcctaactg gatgtactgt tttgcattct 89581 caccagcaat gaaagagttc ctgttgctcc acatactcac cagcatttgg tgtcgtcaat 89641 gttttgagca atagcatttt gatctaactt ttcctaggta ttctttttga aggaaataat 89701 atgacagata atagagaaag gatatacgag gacagttctg tcctttattt atagtccatc 89761 atttaatgaa ggactctgtc cacacttggt atttttaact ctgatcctcc tctcccatga 89821 actctgacaa tctcctaaat ccctgttgct ggcacacatg gttgtgtatc aggccccctg 89881 tggtctgtct gaagcatggc tttttttttt tttttttttt tttttttgag acggagtctc 89941 gctctgtcgc ccaggctgga gtgcagtggc gcgatctcgg ctcactgcaa gctccgcctc 90001 ccgggttcac gccattctcc tgcctcagcc tcccgagtag ctgggactac aggcgcccgc 90061 caccacgcct ggctaatttt ttgtattttt agtagaggcg gggtttcact gtgttagcca 90121 ggatggtctc gatctcctga ccttgtgatc cgcccgcctc tgcctcccaa agtgctggga 90181 ttacaggcgt gagccaccgc gcccggcctt tttttttttt tttttttttt tttgagatgg 90241 agtctgtcac tctgtcaccc aggctggtgc agtgatgcaa tcttggctca ctacaacctc 90301 catctttcag gttcaagtga ttctgccacc tcagcctccc aagtacctgg gattacaggt 90361 gcccgccacc acacccagct atttttttgt atttttagta gagacgtagt ttcaccatgt 90421 tggccaggct ggtctcattc ctgaccttga gtgatccacc tgccttggcc tcccaaagtg 90481 ctgggattac aggcatgggt catcacatgt ggcctgaagc atgactgttg ctttaatcat 90541 atgaaatact gctctgtatt gttatctatt tgaaatgcca cacctcctga gctaaattgc 90601 aagcttttat ggagcacaaa ccatatttat atatattagc atgataccat gacacatatc 90661 aaaagctgtt atatattgtt acgtgaattg attctttctc agttaagagg acctctgtag 90721 tagcactttc ataccgttaa tttttcattt tgtgcccagc ccctactctg tgaaaaatga 90781 aatgaatcct gttatcattt ccctcccagg ccttttctcc ttgtggacaa tgtgtggctc 90841 aagagaaaat tcagtcagta aatttgttca gtgcacaaac tctttatcac ctctcactgt 90901 tctcaagtga gatagaacag aacatccatc cagtgtctta caaattgtct ggtatatagt EPI-109 937

90961 aggcactcaa taaatgtttt ttgaataaat gcatacatga atcctattcc tatatatagt 91021 atggtagaca gatcattgat acccaaagat gcccaaatgc tgatccccag aacttgtgaa 91081 tatgttacat ttcatgtcaa aagggacttt gctaatgtga ttaaggattc agacccttgg 91141 attgtaagat tatcccggat taaccagggc caatctaatc acatgagacc ttaaaaaagc 91201 agaaaacatt tcccagctgg gttagagaga gatgagacag agtaaaaagg aaagagattc 91261 agggcatgaa aatgactcta cccactgttg ctggctttga agatagagga actaggccac 91321 aaaacaagga gtatgagtgg ccttaagaaa taggaaaaag ccctcatctg acagccagct 91381 agaaagcagt cctctgacca caagaaattg gattctgcca accactcaaa tgagcaagga 91441 aatggattct cccctagaac ctccagaaag gaacacagct ctgtaatgcc ttgattttag 91501 ccaggtgaga cctgtttcag acttttgacc tatggaaata taagataata aagttttatt 91561 gtatgctgct aaatttgcgg tagtttatta ctgaagcaat ggaaagccaa tacagacaga 91621 atatacagag agaaagagaa tgagttcttt cctgataatt tgtaaatatt tgggtcttca 91681 ctggacaagc ttcacagagg attcactggt tccctagcaa accagcatgt ccagtcctgc 91741 agcctccctt tcttaggccc agcatatgtc agctgtgtgc atagaaaaat caaagcagga 91801 ccctgagtag ttggaaagaa aagatggttg gaaatgggtt gcacttcaag tgaggaaaca 91861 agaggtagga gaccggcatc tctttctcat atgtcccagg ctgactcttg tgagttgttt 91921 tcccttggag gctatcgatg acagtcacag taacctgatg gaacctggat catgatgaaa 91981 gaagtaagtg tcaatggctc cgacttccaa ggactctgat gtcccacagc actagctaaa 92041 caaagccagt tggaaatgag cttaaatggg gaatttcctg aatatattcc ctattgttag 92101 gaagccaggt tggcttcctt gcctacaatt atgccaagca gtcacactat agagtcccta 92161 gggacatgat attaagtgat tcttttaaca caaacaactt aataatcatt tatactaata 92221 gcaaaacggc caacggctga tattccactt gaagtagaat tggctatcca actggaagag 92281 aagacaggaa gacgtgatct ccagggagcc actaaaagga ttggcacctg cctctggatt 92341 ccccttttcc ttatattacc tctcagcact ggcaggcctt tatttcagga tacagtttca 92401 caagtattat gtcacgtctc tgagaattat gttggtagat atttgctcct ctggccagaa 92461 agacctagtt tggagtctgg agtcatgaag gtgacataca tgtagctagt gacataagtg 92521 tagctagtaa aaatagtgag taatggccct gaaattctat tgaatgccca aagtgctgac 92581 caggaacaag catgctctag cttatctcac aaggaacttg acaattttct tcaaaaatcc 92641 tagtagctaa gatttcttag taacaaagcc actaaggcac aattatgatt aacttgaccc 92701 ttaggtgact tttaaggact attctataaa atattacaac taatagtgga tccaagccag 92761 cacactctgc tatataagat taattgacag tgtccacact ggtaaaataa gttgtttcat 92821 aaatacatta gaattcattt gcactttcta cacagcccca agtccagaac tttccccaga 92881 ataggtctat gttttgcaat ctgctactcc atacagagat ttgagttcac ttggcaattt 92941 agtgctgctt atatgtgacc agttagtctg ttttacttat ctatgcctta aacattacta 93001 tacttactaa ctccaagatg cctggtctca acttgacaaa aataccccaa gttgggaaat 93061 ccttatgtga atatgtagat agtcacaatt gctggttgat gatgatctgt cttttcctgt 93121 atttgagaaa atggagataa aatggaccaa tccaaataat ggattaaaca tgggaatagg 93181 tgagagagag agaggaatac atggtggctc tcagtgtctg gcttaggcag taaacacttt 93241 cgttaataaa gacggaaaat aaaaaaggaa taattggtgt ctaggggaaa ataatgagct 93301 caagttttaa cactctgagt tcccggatgt gagacatcca ggcgcattta tccaagaggc 93361 agttggaagc aacgttccgg agcttaggag agaggcatga ccaaaagctg gtgggactgt 93421 gaaaaggtat ggccattctg gaaaactgtt tggcagtttc ttagaaaatt aaacatgtac 93481 taacaaccca gcaattgtac tcttgagcat ttgtcccaga taaatgaaaa aaaaaaaaag 93541 catttttttt acacaaaaac atatacatga aagttcatag aagtgttatt cataaaaaac 93601 tggaaaaaac tgagatgtct ttattgagtg aatgcttagg caaacggtgg tctatccata 93661 caatggaatt atgcttagca ataaagagaa aagaactatt gatacatgca ataacacaga 93721 tgaatctcaa aggaattaat gctgagtggg aaaaaaagca catctcaaaa tggtatatac 93781 tgtactattt tatttactta acattttaaa aatagcaaaa tcatagagat ggagaacaga 93841 ttaatgggta ctgtgttttg ggatggggag tgagaaaagg gtaaggtgta aatataaagg 93901 ggtagcacaa aagagccttg tggttgaagg attctatgtc ttggttgtag tcgtgattgc 93961 aggaatctac atgtgataaa attgtatggg tctacatacg catacacaca agagcatata 94021 aaactggtga catgtgaaga agctccgcac attgtgccaa catcagtatc ctagtttcaa 94081 tatcagacta cagttataca aaacattgtc attgagggaa actgggtaaa gggaacacag 94141 gacatttggc atatattttt gcaatttcct gtgaatccgt aattatttaa aaataacaga 94201 tatactacat atcaaaaatt taatgtcata aagttgatga gtttacctag tggatagctt 94261 tgttaatatc tgctataaga ctactgaaaa tgacagttat gcaagtataa gctcagagaa 94321 ctttcctccc ccttcgtaaa tgaaatgagc aaaagaaatg aaacaggaaa ggcaagcagt 94381 actgaaaaca gggaagggct cttccccata taactatatc tgcgacttca acagctattc 94441 atccagaaac acagcctctt gcgctaagag gaaactttgg ataacaatat gttttcactc 94501 tccaagagag aaaatggata gattaatttt taagaaaaaa aaaaaaacct caccaatttc 94561 atgctgtggc ttgcaccttt aatcccagct acctacaagg ctgaggtgag aggcttactt 94621 gagcccagga gttcaaggct gcaatgagct atgattgatt gtgctatcgc actccaacct 94681 ggagtactaa gctaagagct aagaacacag ctgagagcgg agaagaaaca aacaaatctg 94741 accaataacc cccactcccc tcattttact ggagtgagct gagactgctg gcaaacatgg 94801 cctttgaeet agcctgaact gtagcaaaag tcatcagata tttttccacc aatcaacaga 94861 cagaagtggg gagaaaacaa tcgtagttca taactacaac aagcagataa acgaaggcca 94921 tggtgaggga tggaagacat tgtgatatat caaaggcagg ctcatttaaa actcaaccca 94981 aattccaaac aaaatatata attgaatatg tattaatgcc aaaggagctt gagtgagctt 95041 tagcacaaac cccgccctcc agcccccacc caaaaaaatc actctgttct ctccccattc 95101 tttgataggc atacttgctg ttttctcaca gccaaggtac agaggggact tagaggaact 95161 agaactctaa tacactgcta gcaggaatgt aaaatgaagc atctacttca gaaaaccatt 95221 ttatcagttt ctagaaagtt aaacatagac ccaccatgca gcccagccac tctactccta 95281 agtatttaca caagagaaat gaaaacgtgt ccccacacag ttgtatttaa aggtgatggt 95341 tagccttgtg tgtcaacttg gctaggctat aatacccagt tactgaatca aatagtaatc 95401 taggtgcatc tgtgaaggta ttttgtagat gtggttaaca gctacaatct gttgacttca EPI-109 938

95461 agtaaaggag attgctcttg atagtatggg tgggcttcat ccaatcaatt gaaggcctta

95521 agagcaaaaa gtaaggtttc ccggagagaa agaaattctg cctcaagact gcagcctcaa

95581 ctcctgcctg agtttccagt cagccagcca gcctaaagat ttgctaggca ttataatcac

95641 atcagctaat ttcttaaaat aaacctcttt atatatattg atacaatgaa tggttatagc

95701 agccttattt gtaatagcca caaactggaa acaacctaaa tgtccttcaa taagtgaata

95761 cataaacaaa ttgtggtata tccacaattt ttacgcagca gtaaaaagga ataaatggtt

95821 gaataaggaa taaacacata acaaggatga accttaaaac cgtaaggctg aatggaaaaa

95881 gtcagacaaa actaatacat actgaataat tccatttata ttgaagttct agaaaatgag

95941 gactaaccta tagtaacaaa aagcagaaaa attttgccca ctggtgatgg agggggcgca

96001 ggtattgtag agtatctgag aaaggacaac tggataaaag ggggcacaag aaaacttttg

96061 agggtgattg atatgttcat tatcttgtgg catggtttca taggtgcata catatgtcaa

96121 aacatcaagt tatacacttt taaaatgttc agtttactgt atatctatta tacttcagta

96181 gagaggaagg aagaaagtgg gcagggtggg ggagaggaaa ggaaacgagg gaggaaaggc

96241 cctaatagga aggattttgg agtttagatt ttaaaatgat aaaggatgtt tgacactcta

96301 ggcatatgac gaatatagga ttatgagtcc acaaaaacca ccaggaagtc atgtatgttt

96361 atacttttaa gtgaaggatc agtggattat caactcccta atgctttgcc tctctatgac

96421 tggctgctgt ccttctcatc ccaatactcc ttccaaagcc ccttgcttaa atgtaagcct

96481 tctttcctcc tttcaacaca tcctgcattc cgtgacaaaa taagttttcc ttaaacagaa

96541 tgtacagcat attatttgta caattaaaaa tttttggcca ggtgtgatga ctcatgcctg

96601 taatcccagc aatttgggag gccgagatgt gtggattacc tgaggtcagg agttcgagac

96661 cagcctggcc aacatggtga aaccctgtct ctactaaaaa tacaaaaatt agctgagtgt

96721 agtgtggcag gtacctgtaa tcccagctac tcaggaagct gaggcaggag aatcgcttga

96781 acctgggagg tggaggttgc tgtgagcaga gatcagacta ttgcattcta ggctaggaga

96841 cagagtgaga ctcggtcccc aaaaaaaaac acattttttt ttaatgtttc ctccttgcct

96901 gtaggaaaaa ggctctgact ccttagcctg ggcatcagag ctctatctaa atggacttta

96961 acctgatttt gtggcactaa ttccattgca gtacttgtcc gctcactggc ctgtgcctct

97021 ctgccactat ttttggaata atgtcctctc tccatcttgt ttactcaact atatccaacc

97081 tctaaggctg tgctcctaca aagcctcccc tggctacttc agcccacaga gatatttaac

97141 tgctctgcag ttcaggacat tcttctgact ctttaaatca catttactta tatatgatct

97201 tgtgatattt tttgttgacg tgtttacttt aattttcttc cataacctat tcattcaaca

97261 aactcaacaa ttatttatta aatgccaagt tagaaaaata ttattgattt tatatagatt

97321 atagatatgt ttgaaatttt atttggcaat ctgcaagtag aaaaataatt ataatgtggt

97381 atatctgtga tagaagtatt agtgcagaga ccatggggaa cataatccag cctggaagtt

97441 caggagagat acgtggaaga aaggacgtca gagccttttt cctacaggca tggaagaaac

97501 attaaaaaaa attttttttt ttgagatgga gtctcactct gtctcccagc ctagactgtg

97561 gtggtgcgat ctctgctcac tgcaacctct gtctcccggg ttcaagtgat tctcctgcct

97621 cagcttccca agtagctggg attacaggta cctgccacac atggatgata aatatgatca

97681 tattttcttg ttcttttcct cctcagttgt cttccctgaa gaaaggaatg ccttttatag

97741 atgacaaact cccattctca agaacaagga tttttgacca atttaattta atcagatgtc

97801 tggctttgac ctagaaacac agtcacgaaa cttggtgatt agagaccaat tcccaaacat

97861 gagcatttct taggaaacac agtaaagatc tgagagaccc aagagcagaa gggcgagaaa

97921 ccaaaagcca tcagtttgca taggaaacac cttgtttagc ctaatctttt tatttttatt

97981 actctattag tcactacaac tattttctga ttgctatggt gatagatggt ttaaaacaag

98041 ccttcattaa gaattgtcac accatggtct cagtcaaaaa caccaacatt tttattggta

98101 ttgacaatta tgggaatatc caattccaag aagacaagga gacctctgaa ctttctaaat

98161 gaagactcca atcttcctga tctgatggga agcagcttgg caagattacc aaccaccacc

98221 acagagagtg gactctaagc taagacttaa aagataagta gaaattatcc aggtaaagat

98281 gtgtacagag aaggaagtac atccagggga aaagaacaat acgtgcaaaa gtacggaaat

98341 ggtaaaaagt aatactacat agtcaaagcc aagcagagtt cagaagggat ctggtggtga

98401 aaaatacggc tagagaaagc agcaaggatt ggcttctaaa acctatgtag tatcttggac

98461 cttaccctaa atgtaatgag aagcttctaa agaatctttc atttattcat tcattgaaca

98521 aatattttga ggctttctgt gaagaacatc attctaagta gtaaagatac agcagtgaat

98581 aggacacata aaatcctaga tctcacagaa ttgacattcc agagagggaa aggtagacaa

98641 taaatacata aacaaatcat ttaacaagat gatttcagac aatggtacgt actgtgaaaa

98701 aaatgaaaca aggtaatgga cagcgaaaag gcactggaag gaagcctgct tacctttgca

98761 tggttagaaa agatctctct aagaaagaga ccacatgtga gctgcgacct gaaggatacc

98821 gagaagctag gtgtgcaaag atgtggggac agaacttttg gactgaatag caaatacaaa

98881 tgcccttggg tgcaagcttt gcctgttcaa ggaccaaaaa gaaggccagt gtgcctgcag

98941 catactaagc acagaggaaa acactgttat atgctgagat tggaattata agtagagcca

99001 gataatatag tctcttatag gtcataataa ggcaaccaga ttttattcca agaggattta

99061 aaaatcactg gaggttttgc actagggtga gaggtgtgat ttgtattttt aaaagataat

99121 tctggagaat taactataat gaggtaggag taaactaagt taggggctat ttcagtggct

99181 cagacaagag ataatggtag cttagactag gatagtagtc gtagaaataa ataaaagtgg

99241 cactctactt tgggggtaga gtctataata ggtttggttt atggatcata tatgagagta

99301 aaaaaaagaa aataaattaa taatggttcc taggtttgta cctgagcaac tgaataaatg

99361. ggtgctgtga attgagataa aggagattga gaatcacagg ctttgttttg caaattaatt

99421 ttgagaggct tattagacat cccagtggag atttcaggtg agtggagccc attgaaaggt

99481 aagggacagg gtcaggtgtg gtaggtcagg cctgtgatcc caggactttg gaaggccaag

99541 gcagacagat cagttgagct caggagtttg agaccagcct gggcaacatg ggaaaaccct

99601 gtctctacaa aatatgcaaa atattacctg ggcatggtgg catatgactg tggtccaagc

99661 cacttggggg gctgagatgg gaggatcact tgagtacagg aggcggaggt tgcagtgagc

99721 caagatctcg ccactgcaaa ccagcttagg tgacagagtg agaacctgtc tcaataaata

99781 aataagaaac gtaagggaaa aggaaattaa tctgatcatt ggcaaatgca tagtatttaa

99841 agccagggga gtagatgaga tactcaaagt aggtgaagat aaggaggcaa tgaaggccta

99901 ggactctggt gtacatttag atggttataa gaggaataga aactggcaaa ataagtaaca EPI-109 939

99961 ctgagcaccc aatgaggtgg agaggaaagc caggagatga agcatcatag aaggcaagag 100021 aagaagggtg tcaaagaggc gaggcagtca tcaacttctg ggcagtcaaa taatataagg 100081 acagaaaagt gaccattgga tttggaaata tgatgagcac tttgagtgga gtgttgagac 100141 agaagaccaa ttagagtaga ttgaggagat aacgagaaat gagaaaatgt aacctgcaag 100201 cacagacaat tcttgagaga cttttctgtg aaaggaaaca gacacagagt cttagcatgt 100261 cttgtctttc tatgggaaat gtaaatagtt tgagatcagg gatagtattt tattctgctt 100321 tttgtacctc tacattacct agcatagagc tagctaatgt gcacttaagt atgttctcaa 100381 ttcttatcgc ctgaatgact ggatgggtga aagaatggat ggatggatgg atggatggat 100441 ggaaggatgg atggatgga.t ggaagacttc tgatttgcca agaagaggat actggtagca 100501 gaaataaaaa cagcactgga gaaagaagag tttagatttt tattctttgg tgtcagttag 100561 acaggaaagt aagacattag aagagtcctt agataattta tgtaattgtt cacttaggat 100621 ttttaaatgt gatcactgat attggacatg ttcctagtga agcatttttg gtgtttcact 100681 ggttgaagtt aataactgta aaattatttc ccgttcagga cagaaaaaca gaaaacttga 100741 agctcctatt agaaagttca agattctctg gggttcttag gatttactgt tcccaaaact 100801 ctgtcaagaa caagaaaatg acctgtatac ttaactggtc taggcaacag tggaaagaca 100861 attctcagag aagatttgtt ttaagaagac actttccata ggaatcaaac aatagctttc 100921 agtgactaac atggtaagac acagggtgtt agctctttcc ttccaacctc atggctgttg 100981 taccttacct ttcgaccccg tgttcctgaa attgttaaat tcataaactt accaaggact 101041 aaccagcctc tggggaattg ctgtatactt agcaaactta caatggacat atttataagc 101101 cataatgata actgactaat aggaaatacc ctcaactgaa aatgagagat catcatttgc 101161 aaatgagttc ccttgcccag gcaactactg gggaaaatgt catgcaagca aaattaatct 101221 ttgaaatcct ccttttccat tttttgtgtc ttccttttcc ataggcacca gaaatatcat 101281 ggtgcctgga tctcatctct acagaaaaaa aaagtgattt gataaactga tttatattgt 101341 gtccaaatgt gattgtattt tcaaagataa cctaagggga gaatgctgtc tggcccaaca 101401 gcaggctctc gacttcattt cagacactgt ggccaatggc tgggaaacag gtatgaacag 101461 taggtttctg agtcccctgg aattattcca tttatgtagc cacctccatg acaggaagcc 101521 tccctactct tacttcccag tttgttcatt catggcacca ggttgcagat taaaatttgc 101581 tcagtgacct tttatctaat aatgtgttac cttcttctct taaaaagtac aagggacaaa 101641 tgctcatggt atacttttag gagattgtgg ctctctatta acagtattta ttcaacaaac 101701 atttattgag catttatatg tgcatcatgc tagggactgg aacctagtaa gtgtagcaca 101761 tattatttca tttaatcctc acaacaaacc catgaggttg gttttatgat cccaattttt 101821 cagaagaaga aactgatatt cagaaccagt taactaactg gttcaaggtc atgcaatttc 101881 taagatacag aaccaagagt caaagacatg attttaaacc aaagcttttt ctgctactcc 101941 acattgcttc cctaggtgag atctgaggca ttccgcgaaa agagaagggt cataaagcca 102001 agggaagaca agcttaggaa aaaaaaggga aatgtcctaa ataaacagct ttcctattta 102061 ccagaaacca ctagtttaaa aatataatgg gaaaaatcct attcacttta acaatgttaa 102121 aaaaaaaaaa gatagaaga.a acatagggat aaacttaaca catttgtagg atatgtaaag 102181 aaactaaaag atgttaataa tggcctaaag aaaaaaaaac ttacatgtat ggggagatag 102241 accatcttac tggattctaa tatttaatag tctaggtgtt ccatttctca ccaaattaat 102301 gtatacattt aatacaatgt caaacgaaat atcttaggaa ttgcttacaa attgtcagat 102361 aattacaaag tttacctggg aaatataagc atatatgaag agtgaatggg accccaccac 102421 tccccccaaa acaaaaaagg tctgaaaagg acagaaatca aggagagtct tgcctgccag 102481 atacaaaatt ctattataaa ggtgtattga tgaaaacaat ttaatactag tgtagcaata 102541 ggcagcaaag caatgaaaca gcataaaaag accagaacta tacctaatta tgatgaagat 102601 ttaaggtatg ataaacatga cataattcaa atcagcagaa attggcatag atagggttaa 102661 gacaaatagc taatcattag aggggaggaa ggaaaggagg gaggataaaa ttaggttcct 102721 gccttcatct tacattaaaa taaattccag atgtattaca tttaaatttt tttaaaaaaa 102781 gaaaccacaa aatacttgaa gaaaatataa gttgttatat agtcttttga tgggaatttt 102841 tttttttttc agagacaggg tcttgctctg tcacctagcc tagagtgcaa tggcatgatc 102gθl atggctcact gcagccttga actcctgggc tcaagtgatc ctcccagctc agccccccag 102g61 gtagcaggaa ctacaggcat gcgacacccc atccaactta ttttttattt tttgtagaga 103021 caggggtctt gctttgtttc ccaggcttat ctcgaacttc tgccttcaag cacctcagcc 103081 tcccaaagag ctgggctgat gggacatttt ttaacatagt gccacattac cataaatgaa 103141 aagcttgtaa aatactaatt tttaaaacta atatatatca gaaattttta taaacaaagt 103201 taaaaagcaa acacaaaaaa tttgtagcac ttatgacaaa tatatgtata tatatgaata 103261 caaaaagagc ctttacaaaa cagtaagaaa acaatgaata ctcccaatgg agtattcaaa 103321 actaaactgc taaaagcaat tcaaaacaaa aaacataaac tatgcatata tgtatgtgaa 103381 aaagtttaac cttatcaaag aagtaaactc tcaaagaaat aaacatcaaa taaggaaata 103441 gccttttccc acaaataacc aaaatctgta agaatactga gctgcgaatg tttcagaaaa 103501 aaaaaaaaat catacaccta gttcggcatg taattaatat agatcagaac actttaaaaa 103561 tatttatagg ccaggcacgg tggctcatgc ctataatccc agcactttgg gaggccaagg 103621 cgggtggatc acctgaagtc aggagtttga gaccatcctg accaacatgg tgaaaccctg 103681 tctctactaa aaatacaaaa actagccagg catgttggcg tatgctggta atcctggcta 103741 ctcgggaggc tgaggcagga gaattgcttg aacccaggag gtggaggttg cagtgagctg 103801 acattgtgcc actgtactcc agcctgggca acaagagcaa aactctgtct caaaaaataa 103861 taataaataa aaataaaata tttatatact ctgacccatc aatttgtcca gcataattag 103921 gcatgtgtac aagggtttac acacaagaat gcctattgca atattgcttt taatgctaaa 103981 aaaaattggg gaaaatgctt taaaaatata gattaagact gtacattgtg gtacagtcat 104041 ataatcaata gtatacagct attatttatt ttcagccact gtccaaaata tagcctggcc 104101 taacaacatt ctgttaggat acgcaagcac cgtgaggaga tcagctataa agtatcagtg 104161 tttcacacca ctgctccttt gctaataacc ttcaatggct tttaaagaag taaaaaacaa 104221 aggcaaaatt ccttagtcag cccttaagac tctctgttac ttagctcaaa ctaccctttt 104281 caacaacact gccctaacca ggatgagttt tttgcccccc tggagtacat tcagcctttc 104341 cttatcaaac cttcctttaa ataagtatct tctccaggac cacttcactt tcttccccaa 104401 tttagcattt tctatatctc caggcctacc tctataaagc ctgtcctaac cactcaaacc EPI-109 940

104461 ctagcttttt ctctgaactg ctagaaatat ttttctctca ttggccattt aggtaaaaag 104521 gtttttactg tttattacct actcaataaa aattttcttt ttttgagaca aggtcttact 104581 ctgtcgccta gaatgggggg aagtggtgtg atcacaactc actgcagctt ctacctccca 104641 gctcaacagt cctcccacct cagcctagtg agtagctgtg actacaggca tgtgccacca 104701 taccccacta cttttcattt tttatttttt gtgagatgga atctcactat gttacccagg 104761 ctggtctgct gatctcaatt gatcctccca ctgtggcctc ccaaaatgct gggattacag 104821 gcatgagcca caatatctgg ccccagtaag cttttaaggc cattaacatg aggaacagtg 104881 ttctttacac tattttatca gctagggctt tgcatggagt aggagtttag taaatgcggt 104941 tgatgggtta atcaatgtgt gaaaatattc agagccacca aaaacagata ttatgtctat 105001 tctcatcaac aatcaaaatt gagtaaacag ccattttcta atacaggaaa ccacaaaaca 105061 ttgaatggtg acattaaaaa attcccccag caggagccaa ccaatttttt catcctgatc 105121 caagttagca aactgcaaaa gataggaagc actaatgagt ggaaatttga gtagaagcat 105181 ttcttatgaa ggctgtcttg actggatcac atttttattg ctgttggagg tgccaaatgt 105241 gtgtgtttat gctaatcctc cacctcaggc aacacacagt caaggatcct accaagtgtt 105301 accgtcaagt gtctgttggc agctcaaggc cccagcgttg ttcccttgca ctagggaaaa 105361 gacatattcc aggtacaagt actcccactt tgatgctaca gaggagttgc tgaactttgt 105421 gtcattaatc tctcttcgtt agatcccaac cctgtttaaa tcccactatc tgcctactct 105481 gggtcttcac caatttacta gatcatagtt ggagaaaatc tacaaagcct tgctcccttt 105541 agatttaaac aggtctccgt ttaaatttag aattgctaac ttcaagcggg cccttatgcg 105601 acagtatgcc tgtcagtcat actacatttc ctcaattcca ttcatgtgac tgctccatac 105661 ccttccctct ctcttcatac tactattatc tcttcccccc tccctcattt ttaactgatg 105721 atcttgtttc ctatttctct gagaaaatag aagccatcaa aagagagttt ccacaaactc 105781 ctactgcctt atctagccct gtaccatata ctttgcattt cctctcatta ccatggatgt 105841 actgcctatc tgtgcttcta tctaaggcta acccttccac ttcagttttg aatattatca 105901 gctcttacca actcaaggcc attgctctag caattctctc attctctctc attttcttcc 105961 atcaagtttt ccttttcttc aattaacaga gtagctccta aagggaaaaa aaagtcttct 106021 ttttcaatgc tcatcatcac tggccatcag agaaatgcaa atcaaaacca caatgagata 106081 tcatctcaca ccagttagaa tggcaatcat taaaaagtca ggaaacaaca ggtgctggag 106141 aggatgtgga gaaataggaa cacttttaca ctgttggtgg gactgtaaac tagttcaacc 106201 attgtggaag acagtgtggc gattcctcag ggatctagaa ttagaaatac catttgaccc 106261 agccatccca ttactgggta tatacccaaa ggattataaa caatgctgct ataaagacac 106321 atgcacacgt atgtttattg tggcactact cacaatagca aagacttgga accaacccaa 106381 acgtccaaca atgatagact ggattaagaa aatgtggcac atatacacca tggaatacta 106441 tgcagccata aaaaatgatg agttcatgtc ctttgtaggg acatggagga agctggaaac 106501 catcactctc agcaaactat cacaaggaca aaaaaccaaa cactgcatgt tctcactcat 106561 aggtgggaat tgaacaatga gaacacttgg acacaggaag gggaacatca cccactgggg 106621 cctgttgtgg gatgagggga gtggggaggg atagcattag gagatatacc taatgttaaa 106681 tgatgagtta atgggtgcag cacaccaaca tagcacatgt atacatatgt aacaaacctg 106741 cacgttgtgc acatgtaccc taaaacttaa agtataataa aaaaatatat atatatatat 106801 aaaacaacta aaaataaatc ttctttttct gcaggatcag tccatcacca cacacacagg 106861 ctgtgtttta tgttgttccc cagcttaaga gatcgttctc cagatcccac tgctccttcc 106921 agttgtcacc tcagttctcc acttcttttt gctgataaac tactctaact agttacatat 106981 gatttctgtc cccaggtccc ctccctcagt tgttttgaac ataatcattt atatcattta 107041 tcattttcac tctaattgca caaccaaaaa ctcccttttt ttttagatgg agtctcactc 107101 tgtcacctag gctggagtgc agtggcatga tctcggctca ctccaacctc cgcctcacgg 107161 gttcaagtga tccccctgcc ttagcctcct gaatagctgg gattatacac atgcaccacc 107221 acacctggct aattgctttg tttttgtttg tgtgtgtgtg tgtttttttt tttttttgga 107281 cagagtctca ctctgttgcc caggctagac tgcagtggca tgatctcagc tcactgcaac 107341 ctccacctcc tgggttcaag cgattctcct gcctcagcct cccgagtagc tgggactaca 107401 ggcatgcacc accatgccag gctaattttt ttgtattttc agtagagacc aggtttcacc 107461 atgttggtca ggctggtctt gaactcctga cctcaaatga tctgcgcacc tggacctccc 107521 aaagtgctgg gattacagac ttgagctact gcgccgggct attttgtgtt tttagtaaag 107581 acggggtttc accatgttgt ccaggctggt ctcaaactcc tgacctcaag tgatccgctc 107641 gcctcaggcc ctcaaagtgc tgggattaca ggagtgagcc accatgcctg gccataaaac 107701 tgccctttgt taatatgact gttggcctgc acattgtcaa atccagtggc attcatctta 107761 ctcggccaac ctacggcatt tgacactgtc tgtctttcct tctgttcctc tatctgtttc 107821 cagtatactg gcctggcttt ctttttacct cttttatatg ctcttccagt ctcaggctcc 107881 tttggggatt tgaaggtatg ttgcattttg ctattcaatg aataatgaca agtaatgatc 107941 acttaagaca ttaagtggtc agttccttta ctaggataaa aataattttc ttcccaacat 108001 ggggcatatt ccatttccag tctgactgtt ctgtgtaatc tttgtattcc ttggcagccc 108061 cttttatatc agttcatcta ctgtgcagga aattggacaa acatttgcac tggtataacc 108121 aaatacagtt gaacttttgg cttgactctt agctgaactc accaaaaata atttctgtaa 108181 gagactgaga cgtctacgag taggtttttc agaattagta aacataaatc aaggatacac 108241 aggtagattt gaatttcaga taaacaacaa atactttttt agtatgtcta ctgaaatatt 108301 tgtatcttat ctggcaattc tacctggtac agaactaatc cattctcttg aaagatcttg 108361 actctgtaat aagttctttg gtgatggaag ggaggtattt ctgtaattag agtcactgtc 108421 ttcctcccag ttttttatcc tggcccagat ctgcaatgaa cacacgacag aatccagggg 108481 ggatgaagat gggtgctttg caggaaaaaa aaattaaaaa catctgaaaa agcttttgta 108541 ctaaaagaat gtgatctaaa aaagaaagca ggagaacttt ctgtctgcac tttacatcag 108601 aacaaccttg gcgtctagaa gctgtgccct gtgggaagtg gtggtgcttg gtaagagatg 108661 ccaggaccag tggtacccac tgggagcact gccaataccc agcaaggagc atgggtgcac 108721 agtaaggcat tgcactgtga ttcagcataa aataacaata agggaacgtc acggagaaaa 108781 ggccagactt cctttgttta gaatgtggga aatgtcttct gaaaaatggt agtaaaaaag 108841 catgcttgga tggtccactc caggcaaaac tgactaatcg ggggtcaggg atacaacccc 108901 tgcatcatat gtttgtttct gttgggctga catgaggttc actgtgacca ctgtggttta EPI-109 941

108961 accccatagt ctcctggaaa tacagccagg tcaagagagc tccacataaa acataatcaa 109021 aaaaataaac tcaagtttcc actgatcagc ttttcacaac tcttatcctt tcactaactt 109081 tggagcaaga tttgagaatt ggatggctat ttgagggcta tttctgcgct ttagttcaat 109141 gttttgttct ttctttatta gagaactatg gttttttatt atatttacac tttaagttct 109201 agggtacatg tgcacaacgt gcagatttgt tacacaggta taaatgtgcc atgttggttt 109261 gctgcaccca tcaactcgtc atttacatta ggtatttctc ctaatgctat ccctccccca 109321 gtcccccacc ccccgacagg ccctggtgtg tgatgttccc cttcctgtgt ccaagtgttc 109381 tgtttatgtg atagattacg tttattgatt tgtgtatgtt gaaccagcct tgcatcacag 109441 tcacttgctt acaagaaaca aacacttcac agatggatca ttatgtgtga taagtgaaat 109501 ccaaggattt atgctcagag gtgggcttaa caggtaggaa gagcagtatt ttccttcaac 109561 catgagtgta tgcaggtttt tcttttcttt tttgagatgg agtctcactc ttttacccag 109621 gctggcgcgc agtggtgcga tcttggctca ctgtaacctc tgccacctgg gttcaagcaa 109681 ttctcctgcc tcagcctccc aagtggctgg gattacaggc acctgccact gtctccggct 109741 aatttttgtc tttttagtag agatggggtt tcaccatctt ggccagcctt gtcttgaact 109801 cctgacctca tgaatcatcc ttctcagcct cccaaagtgc tgggattaca ggcatgagcc 109861 actgcgccca gcccacaggt ttttcaaaga ctaaacttaa aaaaaaaaaa aaaatttccc 109921 aatgaaatat aaaactaaag tgctaaactg tgatagactg ttttacaaga atgccagttt 109981 tcacaagtgt ctatagaaca tgtaatttag ataggtaaga tgaaattttg ataatatttg 110041 atggcaaatt taaacaggta tacaacaaaa ataaaattct aagcccctca accaactgaa 110101 tggactcctt ctctcagcca aaggaatacc aaagtaaacc tgaaaaacta gttttggcca 110161 ggattggggg taggtggggg aagcccaaca tgactcatta ttctctcctc cctttggaat 110221 tcaggcacaa ctgaatgtca gcattgacac taaaacacag atcttaagac tgacaagcca 110281 gactctttgt agcagagagc caggccctgg aagaaatcaa gttattttat cccaaaaaat 110341 atttctttga tatattttca aatggccctg caaagctgtc tcttgtgggg aaaattgaca 110401 tgctgtacag aatttccttc tctttccaag tttttactga tccaggagag atttaactaa 110461 gaggctagca tgtttttttt tttttttttt tgaggcggag tcttgctctg ttgcccaggc 110521 tggagtgcag tggcgtgatc tcagctcact gcaaccttcg cctcccgggt tcaagcgatt 110581 ctcctgcctc agcttcccga gtagctggga ttacagatcc atgccactat gcccagctaa 110641 tttttgtatt ttttgtagag acagggtttc accatgttgg ccaggctagt attgaactcc 110701 tgacctcgtg atccgcccac ctcggcctcc caaagtgctg gcattacagg cgtgagccac 110761 cgtgcccagc acaagacatt taccgtctat tctctctgaa gctactatct agaggcttca 110821 tcaacataat aagacccttg gtctccacaa ctccttatct tatcctatta gtttctactg 110881 attccaggtc tttagataat aacaactctt tcaaccaatt gccaatcaga aagtctttga 110941 atccacctat gacttaaaag ccccactcct tcaagttatc ccgcctttct ggactgaacc 111001 aatgtacacc ttatatgtgt tgatggatat ctgcctgtaa cttccattcc cctaaaatgt 111061 ataacatcaa gctgtaaccc aaccaccttg ggcacatgtt ttcaggaact catgagactg 111121 tgttgcagac cttggtcact catatttggc tcacagtaaa cttctttaaa tattgtatag 111181 agtttggctt ttttcattga cacaggaaaa ataaagaatt ggaaggtctt tcatcagtca 111241 ctgagccagc ttcatatctg actgaggtca tacagttcag tgatttgtag ctttgctact 111301 tagattgcta tccattatct agaagcatca ggatcacgtg ggacctattg gaaatgcaga 111361 ctttcctcct agaacccagg accttggaat attcttggca catagtaggt gctcaataca 111421 tattgaactc ctaggtgcaa ttcattaatt catgaattaa tgaattaaca cgctctcaaa 111481 gtttagtgct ttttcacaga ctagtctttc tgcctcttaa gcactcagct caccacgctt 111541 ccagtctcac tcccctatta gtctgattaa aatctgctta catgtgagtc tgagatcaag 111601 tgttatctct tctgagaagt cttccctcac tggcccaaag gaatttctcc tctattttag 111661 cactgtccca gttgacttgt cattattcta gtctttttca tattagttgt ttttcatata 111721 tatgttatta aggaaactag tcatttcccc taatagaaca aaattgctgg cctttggggt 111781 tggcaatgga ggggaggctc ttcttgaaaa gggggaagag tgttctccta atatttttct 111841 tacgagattt atgttgctca tctttagcct ttagtccccc attgcctgcc tacagttggc 111901 agagaccatc tgttctctca ctgtcaggaa ctgtctcaat tcttgaagtt cagagtcaaa 111961 aaagaagcaa gttttcctag ctctttgatc aactttcaaa gttttacttc catttgaaaa 112021 tttactaagt caccaggaga tggtttatac tgagaaatat ccactcatac tcttcctctt 112081 caactttctt ccatatacac cctattacag ggatatagtc ttactctata gctcaaaagg 112141 atgaccctat cagaaacctg cacagtatgt aaaacattct caccagaggt tcacttgtgt 112201 atttccaccc tagaatggaa gctctacaaa agcacagaat gtatcatttt aactttagat 112261 tctattttca cacccagtgc ttgacacatg atttgaagtt aatatttatt tatcaagtga 112321 ttgttttaaa atcatgactc actcaacaaa gttataagaa taagaatagt gttacagaat 112381 tggtatacac aagctgacca taatcaacac acctattatc atttttttgc gacaggttct 112441 cgctgtctca ccctggctgg agtggagtgg catgaccacg gttcactgca ggtttgaact 112501 tccaggctca agcaatcctc ccacctcagc ctcccacata gctgagccca caggtgtgtg 112561 ccaccatgtc cagctaactt tttaattctt tgtagagaca gggtcaccct atgttgccca 112621 agctggtctt gaactccttg gctagagaga tcctccctcc aaggtccccc aaaatgctgg 112681 gatctcaggc aagagccacc atgcctggcc ataatcaata cacttttaag aatgctagaa 112741 tgttatatca gatgcatact tcagcactat ctcaagcaaa ctggggtgtg ggttattcta 112801 catataaagt tcagcagtgt tgttccacag tcccaaactc caactgaggt caaatgtagg 112861 gtgcagcaag gtcactgggg ctgtcatcaa gggcctctcc ttgcactctt gccaaccctg 112921 tttcttgatt gtctctacca ccatgagtca ccagcaatct cccacagtca cttgtttaaa 112981 agttcacaag tattgtgtga attgcaggca accccttgac tccctgattg cctggtcttc 113041 ttccttgggc tctaccattt tttttcccca gcactctttc tgctgctcta aattttaatt 113101 catgcaattc catatgtgtt tctctatcat tcttcatctc tttcctctcc cttccatcca 113161 attttgtttg tctgtttgct tgcttgcttg ctttaataca tttctctttt tctgagaagg 113221 cttgagtcca aaactctcag ttacctgttg ttctgtttcc cgttagttaa tctccgaacc 113281 ttcataaatt aaatctgaca aagtcccctg actaacaaag gaaatgcaca agtcacagta 113341 aaaggggcac acacagaaca caaatagacc cagggtcttt tctgttcatc actcagcttt 113401 ttataggaga tccaggagaa atgaagtgga aagggaagtg tgttgagtta ctatacaaca EPI-109 942

113461 caagagtaaa ctttcttata agtggtaatt tttttttaca ggaataattg aaaatggaaa

113521 ttaccttctc tactcatagt aagtactcag tgcgttcttg atgggatgag aatgtgtttg

113581 agctttagtg taaggcagaa ttctgtttag tctgccagta ttggagaaaa ataaaacaca

113641 aagggactga catgtaggaa gtggcacctg ggagggtctc aattcttcct attacaaaaa

113701 tgccccagag aaataaaaag cttgtgtaca tgttgagatg ggagagttct ctggcccccc

113761 tcgcaggatg tgtgacagtg gggtggctct ctgctgcgcc accatgagct caaacccctc

113821 ataggagggg gagcacacag gcaggaaggt gcaggagctg ggcgagctct ttgggctctg

113881 gccccgtggt actgtctaga ggtgggtgcc tgcaactcct gaaagcccaa gtgggcatgt

113941 gttacagtgc actctttcag ctttgctgtc tgcagcttaa gcgttaacca gctcagtttc

114001 ttcttggtac ccaggtcctt gtctggcatc caggaagaat caggttacac atggacttga

114061 aggatgaatg tgggagtttt atggagtggt ggaggtggct ctcagtggga tggatgggga

114121 gctggaaggg ggatggagtg ggaagatgat attctcctgg agtttggctg tccagcagcc

114181 gatctcctct ccagtcgtcc ccagcctctc gacgttcaga tgctcctctt ctctccttct

114241 ctgccatgct gttctgccgt tcatctgcct gtctctctct ggagcctgga atttggggtt

114301 tatatggtac acaataaggg gcatggcagg ccaaaaggga actttttagg tgcaaaaaac

114361 aggaatgcct cttctcactt agggctatag attttcaggc ttgaaggtgg ggcctttacc

114421 agcgaacctg tatttccctg tctcctgtgc atatcaatgt aatcaaatac tgggctgatc

114481 caggatgttt ctttagacca attatgggta aaataattta cattcaggtt tttatatttg

114541 cttttgtcat ttctttttaa gcaatcatgt aaaatatcta tacgacagta atagatgata

114601 gcgaacctaa ttaaaattac cagaaactta agaatctcta atgatttcaa ctgtaactaa

114661 ggttatttct ctttatgttg aacaatgttg ggagataaga cacaagagtt tctgaagtat

114721 ttcagaaaca caaagaggga ggttatataa ataatatttt tttcctactt tgggaaaatg

114781 aaagctagtc acaaagttaa acgagtggtt attttaatat ttaaaataca ggcttggatg

114841 tatttcctgt taaagaaaat aaaatgcaga atattcaaaa cgtctgacca cccttctaag

114901 aaaatgcatc tctgaggtat ttttccttag aagttattgt aaaaatcctg gagaagcttg

114961 aacacagcaa agcaaacagg atgcagagtt taatctgtgg aaagcttagg gaagaaaagc

115021 aaatcattaa aaataggtct tcctctgaag atttttaaaa cgcaaagagg gtggaatagc

115081 aatgataata aaaaagctgg catagagagt ggcacaattt gctgtgccac tgagctgact

115141 ggatgtgttc tgaatttcta ggcattagtg tacctttcca cacgcattct ccctttaaaa

115201 aaaatgccca cacactgaat acttttttca tgcaatttaa aataagcgca ccatctagtt

115261 tacagaaatt cactagaagt tatttatcct aaaatagcag agatctagaa gaattttgag

115321 ctctaggaca ttttagacac acagaaagaa gaatctggac aagtcttgac cagacatgac

115381 agaatagaaa tttcttttcc tatttatctc tttgaataaa attttcagga tcttacagtg

115441 gacaagtttg ttatctacac attgtgaagc acattgattt ctcctctgta gccttaggaa

115501 gatctgagag gtgactgagc tgattgaatg atccgtgacc gctctactgg gaccagtagt

115561 agaactttac tggtggagac ctgctggagg tttgagagca gactttgaaa attactagag

115621 ctacacagat actgtgtggc taactggatt atgtttagag gctttcagaa ctatgctgct

115681 gctgctgcag tgtagccagg acgcacagag aacatctaag gctcttgaat ggggcgatag

115741 ggacagattt cagcagccat ctgacttcag tgctcatttt gatgctttcc ctgcagggtg

115801 cagtgtgcag tgtgcagtgt gcagtggtgg gaggctcaca caggaatact tgcttctgta

115861 gccctaattt ccggttcaaa ctctgcattc accttgacag attctttcct tggccaaaat

115921 ttagttaggc ttctgggctt tctcttatgc ccacctgcag actttttggt aaaatccagt

115981 tttagtaaag agctctgcta agtcagttta gcaagaatcc ccacctcaaa agtcactatc

116041 tccctccctg gtagtgtctg gcttgtcttc agcgagaatt ctattaggtt ctgttagatt

116101 agaatcctcc ttacccttga tgcttcctct tagtattttt tcatccactg actccttgac

116161 ccaccttgct cctcggctat aaattcccac ttgcccatac tctgcagtta agactatttt

116221 ctccccacta ctgcaaaatc ccattgccat ggtccctata ctatctcaat ggtaatgaat

116281 aaagtctgcc ttaccatgct ttaacaagta acattgaacc atttttttct ttaacaatct

116341 gctgcacaat gagattacta aaactttatt ccattttgcc atgctggatg tcctcaatgg

116401 aatggctctt gtgagcacca aatcattgtg agaaggaaaa cccatctctt acagccccct

116461 gtaacgtgat gtatgttaca tgtgatgtat gttacatagt tttttttcat gttgatcact

116521 ttttgcccat tttcctatat cttatcagtt ggaagactgt ggaagtttgt agtactaagc

116581 cacaagatga ctaagaagag ttgaaagggc aagtggggct aaaaacagat tttgtttgac

116641 ttaccccacc attcccccta tcatggggct gaatctgcct ggaggaagga gcatctttat

116701 ctttgtactg tgaaccacac agtctagcag cagcacagcc aaggcacttg gggtttcatg

116761 agactaagta catgcaattc tattgtaaag gcttaaaata tatacaactg acccttgaac

116821 aacatgaatt tgaattgcat ggtcagttat acgcagattt tcttccacct ctgccacccc

116881 tgagacagta agatcaatca atcctcttcc tcctactcct cagtctactc aaagatactt

116941 gaagtctact tgaagatgac aagcacaaag acatttatga tgatccactt ccacttagtg

117001 aatagtaaat atgttttctc ttcctcctaa ttttttaaca ctttcttctc tctagcttaa

117061 tttattgtta agaatacaat ctataataca tatgacatac aaaatatgtc ttagttgact

117121 gtttatgtta tctgtaaggc ttcaggtcaa gagtatgcta ttagtggtta agttttcgag

117181 gagtcaaaag gtgtatgtgg actttcaact gcaggggggt gggcacccct gcccccatgt

117241 tgttcaaggg tcaactttac tgccaaaggc aagcctttac atccactttt tccatcccat

117301 cagtaaatgg aaaaagatag ctacagtatc cctgcgtcaa atcttttttt ttgcagatca

117361 caaattggcc actcaccttg ctctgtgagg ggtaaaatgc cccactttct ttagtaatat

117421 ttaagttaga taatatttaa gttataaagt tgttctttgt aatcgttaat tgtaattttt

117481 acatagtttc tttcaaacag aaatagcatt tttgttagat aacctcccgt atagatgatg

117541 aaactccttt taagggctat ctgaatttta attccttgaa aaggcagaaa ttggatagct

117601 agtagtcata aatgtactgt ggcttccccc aaccatctgg gctatataga agctgcatcc

117661 ttggactgca gtagaggagt cttacaaagc acagagcaac ttctctcctg ggttgcgcta

117721 gttatgatgg caattttaaa tgtgtacttt tacccaaaga aaatccttat tatcaacaat

117781 cacaatgcca tcataaccat ggtataaaaa attcaaaatg tcccagctga agtggaggca

117841 aagactcaag ttcatggagt cagagtttcc ttgctattcc tctttttcaa atgaccattt

117901 agtaagcacc tgaagaaaat actatggacg gcattgaaaa gtgaagatag gtttaatctt EPI-109 943

117961 ctcgaaaatc taattctcca gatgaaacgc tgacacttat ccaccccaca gaccctatag 118021 cagatgtgtc actggccatc acatttgaca cagagaagtc ataactcagt cagcacagag 118081 acatttccat gagtttctga accatggaca gaacgtcgtc tgtgggacat gaaaactgga 118141 acttagagga caggcacatc tgagaaatgg gcagtttaaa ggcagaacat agcacatatg 118201 tgactgggtt ttagaagcaa atttacaaga cgcactcttc ttcatcctaa ataatctgca 118261 accaaagctt ccaaaaaaga caatttagga atgcagaggt gaggagtagg gaggggaatg 118321 ggatgagaga gagtggagat taatggtggg cagagcgagg tttagaactt agtggtttct 118381 tcaggttctg aactgaaatt tgtatactgt aaaggcacaa acaccatttt taacaaaagt 118441 gagcaggact tcctatctgg ttcagaaaat aggtgaataa atagtacgaa ttattaaaaa 118501 taataatttc cacttataca taggaaactt gataggaacc atgataaatg cttaactctt 118561 aatcttcaag gaactctgct agggatataa tattataaat cttgttttgc agatggagaa 118621 attgaatttt aacccaagtt atcataaccc ttaaatgatt aaatgatact gttacatgag 118681 aaagctgcgt atctgtttcc tggatttgta gccataattt gtgtctcaag tcccttttgc 118741 tgccagctat cttgggtagg tgtgttccct ttgggctgtt tgataccccc acatttatct 118801 tttttttttc tctttttttg ttgagagagt ctttccctgt tgcctaggct ggagggcaat 118861 ggcgcgatct cggctcactg caacctccgc ctcctgggtt caagtgcttc tcacgattct 118921 cttgtcccag cctctctaat agctcggatt actggcatgc accaccacgc ccacctaatt 118981 ttgtattttt agtagacaag gggtttctcc atgttggtca gggtggtctc aaactcctga 119041 cctcaggtga tctgcctgcc ttggcctccc aaagtgctgg gattacaggt gtgagccacc 119101 atgcctggcc ccaaatttat ctttaatgcc ccaaattatc tagttcccat gactgggctt 119161 ctgctttgat cctttctgca cttgctggac cctctccctg ggaaatgaga ttgtgtcctg 119221 agcccctagt tagaggctat gtctctgctg ttcctgaatg ggcctcctgg atgagacctc 119281 attaaaagtc taattctctt ggagaattga gagataccta tttgtctcaa aatcattgaa 119341 accaattaat gtattatgag cctctatcca gtgatttgta cctcaattcc ccaatccagc 119401 tgtcaaggcc aatttgttct accttaccta gtaggtaagt ctggaattgt agctgtggca 119461 ttttcagtaa tggtactcta ggttagcagt ccccaacctt tttggcacca gggaccagtt 119521 ttgtggaaga caatttttcc atgaagggct gggcagggga gtggtttcag gatgaaactg 119581 ttccacctca gatcatcagg cattagattc tcacaaggag tgcgcaagct agatccctca 119641 cacatgcagt tcacaatagg gtgtgcactc ccatgagaat ctaacaccgc tgctgatctg 119701 acaggagaca gagctcaggc agtaatactc atttgcctac cgctcacctc ctgccgtgca 119761 gctcagttcc taacaggcca cggaccagta ctggtccacg gcgcaggcat cagggacccc 119821 tgttgctagg tataagcatc tggctgctgc atgtcttctg tgtagctaca tctgtatgtg 119881 tatctgatga gatataaatt atttgattat aaattacttt cttcatatta gagttgtgaa 119941 tgagtatcac atataattat acataaacta ggaatatgct ttttaataat gtatataagt 120001 aagtttcctt aactatgact ttcatcttag cgtagtaaga gggtgctaag aaatatttgt 120061 gatgaaaata ggcattggta gagttgagac cactgggtga tgaaagagtg taaagatttt 120121 aaagccttca gatgctggtt caaggtgaga aatgtgattg ggagcaaatc aattaacttc 120181 ttgaagtctt atagggcagt tatgaatact taatgttaac atatgtaaag ctcttctgcc 120241 ctgtatacag taaatgctag ttagctatta tgatcactac taaaatgggg atgacataaa 120301 cctcataagg ttttaagtat tatgcaagat actatacaaa gtccagtaaa tatcacattc 120361 aattgaatcc atgatgtccg attattttag ctacttccaa gagagaaaaa aatgctgtca 120421 gttttactgt tcttatagag agcaaggcag atcccaattc ccaatgtggt aacgtgaaaa 120481 tttttgcatt tgaatcaaca aaacactttc tcctttcttt cctactattt aacaactggt 120541 aagtctatac tcccccaaat ctggaattct cctttcttat tctttttcct cctaccaaga 120601 ccgcaggatc ttttacttgg ctataagggg taaacctcaa gtagtacaag ttctctgtat 120661 tacttttata ctctgtcaca gattcccttt gtttcctcat ctccatgtga atttagttaa 120721 attctcagca ttctgatcct tactatacaa ggtaaatgaa tataaaaaca aaacgaaaca 120781 aaaacctctt cctatttaca taaggcccca acctaatatt tagtgatata tattaatgtg 120841 aacaaggaac taacgaagac tgggaagaaa ttcacagact tgagagaaga aatggcagga 120901 tttcctggga acaatttcat gtaacgtcaa aggtggtaaa aggtcaaata gaatgaagat 120961 ggagaatacc ggattttctt acaaaatgat ttcccaggag atctcatcaa atgcacgagg 121021 ataccttctc agtttcacct agtgagtaaa agactggtaa catagctcac ttacaatttg 121081 gataaacaaa actaaacaaa caacatcaaa atttcagaaa aaataatagc aaaacagaaa 121141 tcaaacactc aaatttttgg tccttctgtt tatttcattt tggatactca gtgaatgtta 121201 attaaccagg aaacttaaaa gttatttcaa ttatgaacct cttcaatcct tcatcaatta 121261 ttttgagtat tctggtctta aaaacatctc tttcttctac aaacttctga aagagatgaa 121321 cacctccacc tacaccaaaa taatgtgctt tgctggccaa aagtacacgt ccatttttac 121381 ttaacagtct aaggaaagtc tggtgcaaat tactataata atctgggttg taaatggttt 121441 ctgaggtgag aatgagatca tattttacaa aaagtttttc actacttagt acaagcttac 121501 aaaactcaga ccactcacca gaaaaaaatc ggcatttata tagttgtgtt acttttggtt 121561 tcctgcatct tttcacatct ggctcattta catcattttc ttcatcttcc aaagtggagt 121621 tagctactac attaggtaag gttacttcat caatcaccat actgttataa tcttgaaagt 121681 gaatttcttt ggaccctccc ttgaatgcag ttatacctag taaacctgat ccacaaccaa 121741 gatccaagac ttttttccca gcaaatttca ctttggcctt tgtgaaataa gccaggaggt 121801 caaaggtaca ttcccagatt tttaagcctc cctcataaac acctgtaatc agatcagagt 121861 gagaagaaaa gctttttgaa actatgtttt ctccagggaa gttctctttc aacaagatgg 121921 ttttcactac tgataactta acatgctgga aacctggtaa tgtttctatg actttatttt 121981 ctaacatctt ctttaaatct ttaggcatag catgctcttt ggcagctctc aaggagggct 122041 gttttccatg tggctccaag ttccttgaac tgctggctgc actgagtgga ctgtctgtgt 122101 cttgagaggg agctgcattt tccattgact tatgttccca caagtgatcc tgaggcaagt 122161 caaattgttc tgcagaacat tttctgtccc tctcttctcc tttttgactt tctgagactg 122221 acagctcttt tgaggaatcc agggtcaaag ctccatctct aatgggtgtt aattcatttt 122281 ccagatggtc ttctatagtg aaattaaact gaaaggtcat cctcttatta aatgcacaca 122341 atctttaaat tcagattctt caacttctgg atagaatttg atgatacaca caaatctgcc 122401 tcaattattc aattagtttt gttgggccca atttctcttt agcagcttat acatggtaac EPI-109 944

122461 aaatatttag agatatttcc aaatgacttt ttagacgtct ttggtcctct ttccaagcag 122521 ctctggaaag aaaaaaaaaa aaaaaagaaa gaaaatgatg attaaagcaa aatggcacat 122581 ttcactaaag tgtaatatta aacagccacc cccacccctc cctgtcccac catacagctg 122641 ctttttctta aaaagttgtg gggaagagag agagataaga gatttggaca ctcatacaca 122701 ccttaagggt tccaaagtgg gagaagaaaa tcaactataa aaacaaacag aagaacaaca 122761 gcaaccacca ccactaccac ctggacaaac ataaagtcca agatattcag acaggacagc 122821 ctagctactt gctgtctttc agctgtcttg atttgtgtcc aaccatattc accccctaag 122881 cttccagaat aacttcactt ctgtctttta cagaagaggt gcagtatttt attttggtaa 122g41 gtcagcgtcc ctttaaaaac atgcataggt atggcctggt gtgtgtaaat tcatccaaga 123001 cttcactcca aacatttagt cgagaacagc agccctaagt gtatagaagt gggggtaatt 123061 tggcaataat tagtaaagac taattcggtg gcagagcaaa cgcaaactag ggcactgcag 123121 tagtttggag agacctgtag aaataagaag caactttatt gagaatcttc tatctactgc 123181 gctagacact ataccatctg cctcaatttt cacagttctg gcaagtggga tctttgttcc 123241 ctttatacaa gatttacaat ttgggggaga ggcgggtcac ccagtcccgc ggctaggaac 123301 gcgcctcttt cctctcccat cacgctgcaa ggcttggagt cacttccggc tgcaggtccc 123361 ggaacaaatc cgaccccaga agtggggact tctggccctc acctccccat ttgaatgtaa 123421 tgtttacagt gatccagacc tggggatgct tgcttcccga cgtgtcctgg gatcgcgctt 123481 ctgaaaaagc tcacctcaca acgcctcctc cggacctaaa tcgcgcacca gtgagtcgag 123541 tcctccaggg gctagagaag cccgactttc tttccggcct tgagggaccc gggctcacca 123601 agaaaccagc cgccctcctc tctatggttt tggagccggc ggagagcgcg caagggttgg 123661 cgggactgcg agtttccggt ctgggctttg gcgggtctgg tttgaagctc tcctgtttga 123721 cgaaagtatg tctcaggaag gtgcggtccc agctagcgcg gttcccctgg aagaattaag 123781 tagctggcca gaggagctat gccgccggga actgccgtcc gtcctgcccc gactcctcat 123841 atccttcctt ggttgtcact tctacctaga gaagggtgtg ggcgggtcgc gaacctttct 123901 cttctgtccc ttcagaccca ccgccaggct gggttatatt accgcggcct gaaccccctc 123961 ttttctttgt cagtgagtgg gatgaaaagt gagggactgg aggggaagcg acaaccgtgg 124021 tagatttaag taaggctttg gccctggaaa gcctcgcgga cgtgttctga cccaaggttt 124081 tagcagtgga tgtggcgttt tcttccattc cttctttcag tttttctgta ctcgttgctt 124141 gcaattaagt gtaaatactt ttgctagtgg ataatggggg aggcaaggac tgagacctgc 124201 ggtatgacga tagctctggc tcttaatagt ttgaggtaaa gcgagatact ctgagctttt 124261 gtctcccgta aaaagggtgg tgaatatgaa taagggcttt cttagcgtta taagaattaa 124321 agggcatagt tctgtggtgt gaaatcttta aaagatgttc agtaaataaa aatgattttc 124381 ctccttcccc tctcagacct ctttttcttc tttctttctt tttttttgac aagttctcac 124441 tcctctcacc caggctggag tctttctgaa agagttcttc cgcttgttgt tggctttcaa 124501 ctgttggatt tgaggcgctt agcgccttct tcgtccgggt gcagcacatt cttgattggt 124561 ctcatgcctt tgtggttgta aatgtgcctg gaatcctagc ctttcatggt aaaccatatg 124621 tatatgtatc tttttcacaa catttgagcc cagctttata caattacact caaaagaaaa 124681 aaagtaacct tcacttgaga gaatctcaat actgcacaaa tattgtgcag ctaaagccct 124741 atgtaatcac atagaagtca ttcacctagg cattagcaaa atctcagaag gtgccaaagc 124801 cccctttttt agtttttgtg taggtacaga actgccgtct tcaaggagtt tcaacttgaa 124861 aacaaatagc caccctcaaa acattcaaaa acacttaaac tgcgtgcata atgtgtgtga 124921 gacatggtgt taggctttgg gagaacagag acacggaacg tgattcctct tcttccccac 124981 aagcttatag agagacttca ttaagttgaa agtcaacatt cccacctagc tttgcacttc 125041 aaacgacata ttcaaaaaag cccaaacttc ctctagtttt cttcatctga gtaaatggtt 125101 tcacaaactg aaaccttgaa tcctctctgt ctcacacacc cgatcagtaa gttctattgt 125161 ttctgattcc aaactatgtc ttgaatcaat ccgtttatct ccatcctcat tgctaccact 125221 ctgattccaa acccttatca cctctcactt ggagtattaa tagtttcctt gtttctactc 125281 ataattcatt attccaaaaa agttaagagg ggaaaaacat agatctcgtc atttcccttt 125341 ttaaaccact ttaccttcaa ggttccaggt gatctaagcc ttgcccttct ctcataccta 125401 gttaattaac tacactctgt tcatgaatac attaggctca cctacctcaa gatctttttg 125461 ctcagcctga tttgttctct cagccttttg catatttcat gtttatgtct tggcccaaat 125521 gtcacttcct tagaggggct ttttcagagc cttcaatctt aggcagttcc cccaaacgca 125581 gtcttacact tgtatcacat tggcctgttc agttttctaa aaagcacatt accattaaaa 125641 gaaatgctct tgtttgcttt gtatattttc cacttctaca cattatgttg caaagttcat 125701 aaaggcagga tgttgatttt cttcacagcg ttaccctcag cacctagaac agtgcctgac 125761 acatagtaag cattcattaa agggctaaaa atatttcatg ttttaaaaat acttgggagt 125821 ctaattagac aatacttttt ttcagcttaa tggtagtatt ttagcttcac tattttaaca 125881 aatgaaaaat ttgcaataaa tctacaatgc cattaccccc caaaatcttt ttcatgtttt 125941 gcattttacg tattattttc caggccttac ctgcatgtct gcataatcat aactgactaa 126001 ttttggaaca gctggtaatt atttgagctt tactgaaatt ttttcatgag gccaattcta 126061 ccctactgaa ctcaaatttg agttaatgat gacctcattt tgattgctgc tgtaaaaaat 126121 aagatttcgg aagaggaatg aattcttgta ttactgtggt aggactatgg gttttttttt 126181 gtttgtttgt ttgttttgag acggagtctc accctgtcac ccaggctgga gtgcagtggt 126241 gcgatctcag ctcacagcag ccaggttcaa gtgattctcc ttcctcagcc tcccgagtag 126301 ctgagattac aggcacgtgc caccatgccc ggctaatttt ttgtatcttt agtagagatg 126361 gtttcaccat gttggccagg ctggtctcga actcctgacc tcgtgatccg cctgcctcag 126421 cctcccaaag tgctgggact acaggcgtga gccaccgtgc ccggccgggt tattcatttt 126481 tcttattaac attctttgat gattcttatg gtgttgttac agtaaaacat ttctaacaat 126541 tattctaaca attattcttg atggtgtata tgaagaattt attgtcgtgt atttgtaagc 126601 tgctatgtgc agaagaattt cagtcaaata aagttggtaa gataggtatg taagtaatat 126661 gaaaaaagat agaaggtgat gagtgactta ggtataaatt aagtacaata gaaatgttga 126721 ggaaagaaaa atttcttgta atagaaatcg gaagtacaaa ctgggcatgg tggtgtgcat 126781 ctctaatccc agctccttga gaggctggta tgggaggatc actttagccc aggagcttga 126841 ggctgcagtg aggtgtgatc atgtcaccgc actccatcct gggtgacagc aagaccgtct 126901 ctcttttttt ttttttttga gacggagtct cgcctatgct ggagtgcaat ggcgcgatct EPI-109 945

126961 tggctcactg caacctctgc ctcccagttt caagtgattc tcctgcctca gcctcctgag 127021 cagctgggat tacaggtgtg cgccaccatg cccagctaat tattttgtat tttaagtaga 127081 gacgggttct caccatactg gccaggctgg tcttcaactc ctgacctctt gttcgcccat 127141 ctaggtctcc caaagtgctg ggattacagg tgtgagccac cccacttggc cccgagcgag 127201 accctctctc taaaaaaaaa taaataaata aatcataaac ctgtggatta ttgtagcatt 127261 gtttctcatc tgtcaaaaat atttcatgac tatgcatagt ttgaaaaggc aagtttgtcc 127321 ctgggcaatt ttcaaaatat ttctttaatg tgttttcaca atactgttta cctaataaat 127381 cttaagtttt taaaagcaaa attaagccag taatttgagt ccaattccaa tctcttatga 127441 gtcattgctt aaatttcaaa agggttttat ttttttttta ggtttgttct gagtaatgaa 127501 taccctatta ctatgatact agtatcttcc ttaattatcc tactcattgt ctcaacattc 127561 tgacagttgg attgagcata ttcgtaagta aaattgtttt aactgtatga tgtactttga 127621 tgttaaggtc cgagtcccca catacctcgg tagatgtgtt cttacagttt tgtattccct 127681 tgaaatgtaa ctgttctcta tgttacagcc tttataacct tcagttactt gaaatgaaca 127741 aattcattca aattccagca cttaaaagtt ttaaattaca ttttggataa ataccaaagt 127801 gttttgttga tgatgtatgt ataaacaaat tgtaaatatt aaacgttagt tgttacgatt 127861 agacctatat aaaacatgat atgcagtcta ctgaatagct atcagcctct aacatgttta 127921 gtgtcattta gaaaatgctt tctaaattgc caaaagctga ttgtctaggt gataacaaat 127981 ttaccatttg gaggaagttg actttctcat tttcatgtct tcatcagtct tacttgatga 128041 gattcattct tctagtcaga agagagttta gactgctcag tttactcata ttttgagtta 128101 gcttttctat ttagagttca cttggttgtg gaatattcat ttataatttg aatctacgtt 128161 gtgtaatggg acctaatttt tttttccttt gtttttgttg gagtctcgtt ttgtcaccca 128221 ggttggagtg cagtggcgtg atctttgctc actgcaacct ccaccttcca ggttcaggtg 128281 attctcctgc ctcagtctcc caagtagctg ggattacagg catgcttcac cacgcctggc 128341 taatttttgt atttttagta gagatggggt ttcaccatgt tggccaggct ggtctcaaaa 128401 ctcctgagct caagtgatcc tcctgccttg gcctccataa gtgctgggat tacaggcgtg 128461 agccgctgag cctggcccca gagtttgttt tgttttgttt tcaagacaag atctcactct 128521 attgcccagg ctggagagca gtagtgcgat catagctcac tgcagcctga actcctgggt 128581 tcaagctatt ctcctgcctc catcttctaa agtgctgtga ttacaggtct gagccatgat 128641 gcttggcctg tgtttttgtt tgtttgtttt gggggacagg gtcttgcttt gtcaccaaaa 128701 ctggagtgta gtggtgcgaa catagctagc tcactgcagc ctccatctcc cacgctcaag 128761 caatcctctc acctcagcct tccaagtagc tgagaccgca ggtgcgtgct accatgcgtg 128821 gctaattttc tatttatata tttatttttt ggtagacatg aggtcttgtc atgtttccca 128881 ggtggtcttt aactcctggg ctcagacagt cctcccgcct cagccaccca aagtgttggg 128941 attacaggcg tgagccacca tgcgtggcat aatttttttt aagtaaatta tttttttatc 129001 ttgagtatag aagtgattca tgttcattgt ggaaaatatg aaacatatag aaaaacagaa 129061 aagattacaa aacatctaat ctgaaatggt taagattttg atgagaacag tctcatctca 129121 tttccgtata ttcctgccag cctatccatc attcttcgta catgtttatc tacattaaaa 129181 ttggtgttat attttggaaa ctttttgttt aactacattg tgaacatttt tcatgtttta 129241 aaatgtcatt ttaatgatgg cagatcctat tcaatagatg tacacacacc tatttaactg 129301 gtccacaatt gttggatatg taggtcgttt cctttctctc tttttttttt tttttggcta 129361 ctacttaata gtttctctgt atagaatgtg gtattttgaa agtgtatcaa gctttagatt 129421 ggtagtattc ttgcatttaa taaagggcag tggcctttgt tgactgacat gacaatattt 129481 ttataaaatt tgttatttgc tttacagaaa ttttgaaaat tattgtagaa atgtttttac 129541 ctcatatgaa ccacctgaca ttggaacaga ctttcttttc acaagtgtta ccaaaggtat 129601 aatactatta cctgaaaata catgttataa ggaatctagc ctcagtctta gatgatttat 12g661 tattaattat ggctctcttt ttctaatata tcaaatatat tcaaaataaa aataaggagt 129721 aagtagatct catgtgagac tataatggtg ttagtgtgat cattaggcag ttaaaaactg 129781 ttacaggctg ggcacggtgg ctcatgcctg taatcccagc tctctgagag gctgaggtgg 129841 gcagatcatc tgaggtcagg agttcgagac cacccatggt caacatgatg aaacctcgtc 129901 tctactaaaa gtacaaaaaa ttagctggac atggtggcag gtgcctgtaa tcccagctac 129961 ttgggagact gagacaggag aattgcttga gcctgggagg cggaggttgc attgagtcaa 130021 gatcgtgcca ttgcactcca gcctgggcaa taagagcgat gctccgtctc aaaaaaaaaa 130081 aaaaaaaaaa aagaacttat attttcagat tgtgtggttc ctttactaac tgaatttaaa 130141 ttatttgtag tcaattttaa atgctcttgt attttaaagc cactgtactc cagcctgggt 130201 gacagagtga aacccttaat tcaaaaaaaa aaaaaaaaaa aagaaaagct ggaatattgg 130261 caaaatcaag taactaagag aaaacattaa attcacagaa tacattatta cattttagat 130321 atatatggta tatgttttct ctgaaaagca caagcatacc ttttttgttt taaatggagg 130381 gaactaaaga tactttggtg ccaaaatgaa acattatttg taattaatct cttattgaaa 130441 tgggtttcta actttagctt tgaatcgtaa tctttcaaat ttcttgtact catagtcact 130501 tgatgattct ctatctgaaa tatttcttag aatttgttct tgaccaccag aaaaagattc 130561 aactgttaca tagatgaaaa tggatgttga gtgttaacag gcctatggga aacagtattt 130621 tctttagcta cattgtattg ttgactgtgt tgctattctt ataatgttta ggtcatttaa 130681 attgttagaa agatccaagt attaagatct agggtggcta acttttcaca gacaaaaagc 130741 ttgtttgtaa ggtcatttac tataccctta attcaggaag gttagcttga attgggtcaa 130801 aaggaaactg gttagaaaat aagtgagtag tgaataggcg attcagtgca aattccttcc

130861 agaaaatacc cttgtaaatg actgtatgaa tgtggattct tcaagacagt caaatttatt 130921 gtgcgaaagt aatactttta ttttttgcat ctctaaaaca tgaactttga gtgatttttt 130981 aaaaaaattg atgctattaa atagattcaa accatagaaa tggaaaataa atttctgttt 131041 ggggcttttg gggggattat gttgtaaaaa taccttttct ctgtattttg tgcttaatta 131101 ggtacaattg ttaagctaga tgatagcctg tggatgttac tagtgcaaaa tcaaattatc 131161 gtattgtgtt ttctctgtaa agttttgtct tgtcttttct agtgatttct cttattcctg 131221 tttattactt gatttgtttt tacagactgt gaaattattc gatgacatga tgtatgaatt 131281 aaccagtcaa gccagaggac tgtcaagcca aaatttggaa atccagacca ctctaaggaa 131341 tattttacaa gtaagtcaaa tgtattagaa agcaggagag agagggagct taaagaatgt EPI-109 946

131401 caaaattttt atactgatac tgattagcta tgtattctta tgtaatggcc taatgttgga 131461 attaaattta tagaattaaa gacgtgaata tagaaacatg aattctgaat aataaactct 131521 tataagaaga gaagtcatca agctagctga ccctacctgt attttcaagg atatgtgtgg 131581 aacacctgcc atgtgttttg aagtttgtgt tagtattcta aatggctaga cagttgttcc 131641 agtatttgta gttctgatag actaaagttc tgtgaaaaga ggaagagact gtgttttgtt 131701 cattgctgta tttgtagcac ccagcatgct gactaatacc ttttcagtgc acaaaaaata 131761 tattctaagt gaaatttcct tccttattca cagacaatgg tgcagctctt aggagctctc 131821 acaggatgtg ttcagcatat ctgtgccaca caggaatcca tcattttgga aaatattcag 131881 agtctcccct cctcagtcct tcatataatt aaaagcacat ttgtgcattg taaggtgagt 131941 aaaggtctaa ttatactttg aatggtatat aatcaatgtg cataggggct gagtaaaata 132001 atgtttgtat aagattttac attttagtct atattattga aataaacttt tccatagaat 132061 aaagaacatg taagtaaata attgttgcaa aaaaagtggt tttaaggaag tcattaaaag 132121 tggctttttg gggtttttta gttttatctt atttcccctc tataaagaaa gaagttttaa 132181 gaatttgtgt tgagacagac acagggatcc tgaaatagtt atgtcatgtt gcattgacca 132241 atattcaatt accattatga ttagatgtca gaacttcctt ttataaagga aagttaatcc 132301 ttatttagtc catctctaca tgccagaggt agccttgagg cacaaaagct tgcctagaat 132361 ttatgggtca cagacagttt taatattgct atttgttggg cgaatgaaaa tcactagtta 132421 attaatacct ctctttgctg ataggatgct aaaaatgtca cgcacctggc ctaatgttac 132481 ccttttttag ttctgtattt gcaagatcat ggaagtcaga aataatattt tatacatgct 132541 tgcatctctt gaagcacact atatttaatg gatgttcact aaacaatgaa tgaatatgtg 132601 attcagtaaa tttatgatct ctaatagtat gaattaaagt aaatttggct cttgagcttt 132661 gatttgtttt ttctctcatt tttatttatc cgtaatcaga atagtgaatc tgtgtattct 132721 gggtgtttac acctagtttc agaccttctc caggctcttt tcaaggaggc ctattctctt 132781 caaaagcagt taatggaact gctggacatg gtttgcatgg accctttagt agatgacaat 132841 gatgatattt tgaatatggt aataggtgag tgaagaaaac tttctgctta gtatatggtg 132901 actataaatc atgtatcaat taaaattgtc tctaatgatt catgttattt tcttactaat 132961 tatgcattaa aattgattta aatcttacca aataaatttt taatcttgaa atttggaatt 133021 tgtaaaattt attttgggta ccttaaccta gatttgcgta tttagttact gtaatttctc 133081 cacaatgatt aacttatata actttataat ctctgaggtt gtccatattc agagacaata 133141 actttcacat ttttttaacc ataactgata ttgagatgca gtttatattt ccttccagaa 133201 tacatataaa tacgtgcata tgtgtatgta aatatgtcta ttctcatata catattataa 133261 tgaaataact cattttacat gtgatgcact ttatactagt ttatttttat tttattttat 133321 ttttttgaga cagagtctca ctgtgtagcc caggctggag tgcagtggca caatctcggc 133381 tcactgcaac ctcgcctccc ggactcaagc gattctcctg cctcagcctc atgagtagct 133441 gggattatag gcgtccgcca ccacacctgg ctaatttttg tatttttagt agagacaggg 133501 tttcaccgtg ttggccaggc tggtcttgaa ctcctgacct caggtaatcc acctgcctca 133561 gcctcccaaa gtgctgggat tacaggcatg agccaccgtg cccagccaat actagtttat 133621 ttttaaagaa ttgctggtcg taacacactt cattgatttt atcactcatt aatggattat 133681 gaacaagagt ttgaaaaaca atataaaggc aaagtttgca ttcaaaactt tggtataaag 133741 agagtaagtt ggttttgtgc agtgtatcag gcacctgttg ctctgcaaca caccacctca 133801 aaatctattt attcactatt tatttattca tgattctgtg agtctgcagt ttagggtggg 133861 atgtcctgag acaactttct ctgatccacc tggggcacta gctcacccat gtgacttcag 133921 tgacttcatt cacatctggc tgttggcaga ggcagaagta cttgagaaag ccatgtgcat 133981 catccagcag gttcacccta tctcagatac ctgatgccag tggtttcagg gtttctaaga 134041 gtagcaaaag tgtgagcagg tcgctgtgtg ctagcacttt tcaagtttct gcttgcctta 134101 attttattat tgtcccccgg gccacagcag gtcatagcgt ttagcccaga gtcattgtag 134161 aaaagtgtgg attcacaaag ggcagtcatt gtggccattt ttataaataa tctaccacag 134221 actgagtaaa agccttgcat gaataccatg gatattaatt tgaattcttc ctttttagat 134281 tttctttcct tagcaatttg ttttgtcatt ttggattaga attatatctg tagaatattt 134341 cagttataat agggtacaac ttttattcca ctgaacatct ttagttttat ttaggtcatc 134401 tggtaggtat aaacttcaga agttaatatt caatatttat aaaaaccatt aacaagtgtg 134461 acacttaaat agtttaaata attcttttga cacaactgtt tccaagttgt gttacgtatt 134521 ttaattcaat caaatgttga aattgttcag tagatagttt taattatagg agaaactcac 134581 ccccatgaca tttggatgtc ttaaaagttc tgttatcttt ctttgcagtt attcattctt 134641 tattggatat ctgctctgtt atttccagta tggaccatgc atttcatgcc aatacttgga 134701 agtttataat taagtaagtt tgtttgttat tttttacttt ttagaaaatg ttttccatat 134761 tccccaatct taattattca tgattcttta gattgcattt aaaacatttt gtgtgaattt 134821 aatgttcact gacactgctg tctgataatc cagatattct acatgtagct ctcaagccaa 134881 attggacttc tttaccctgt ggcctctaaa attaaaaaaa atgttcttcc tagttagcta 134941 gtacttcaga aataatgggc catgggccag actagaactt aaccactttt cttctgctac 135001 tgttgtttaa ccagctatca agtatcctat ttctaggatt agataaattg ataactataa 135061 ttaaaactga atataatctt ttcattaggt acttttaagt tgttcacact taattccatt 135121 tgtacagtaa ttttaacttt ctgaaactga agcattttaa agggtcacca gggatagtgc 135181 ctgtagcatt catcagattc ttaggggtga gaggagatgt ggttgagatg taaaaatggt 135241 taagaatatc tactttatac acatacataa aacattaaag gtcagtgtat tttcaggtct 135301 taggtacttt tcttgtacta ccaggacatt aagttgccat tcagtggtta agagtgttgc 135361 ctgggagctg tatcacatg.t gcttaaatcc attcttgaaa tcatttactc cttctgagcc 135421 cttgggctat ttggttaatt tctctgaacg ttagtttgct catctgaaaa tggaaataat 135481 aatagcaact tcttgacagg gttatagtga gaattgagtt catcactgtg aaatgcttag 135541 aaatgtgcat gacacatagt taatactcaa ggaattagcc acatcactat catcatcact 135601 gattatcttc cactcttacc ctcttccagt tcattttctg cccagcagaa tgatctttta 135661 aaaagtaaat cagatcatgt tactctattg cttgaagtct atcccatttg attaagaata 135721 acaacctaat cctctgtgga tgctgcctcc ttcaccagcc tgtctcatgc tgctctccct 135781 actcttagtt cctcaaacat accaaactct cctgtcccag agtcttttcg tggtttttcc 135841 atctgcctag gatgcttctc tctcctattt tgtgtacctt gctaactcct gcttactgtc EPI-109 947

135901 tttcagttct cagcttaaga gttatatctt catgataaca ttctttgata tccttaccct 135961 aagattaagt tagattgata tccttaccct aagaataagt tagattaggt ctctctattg 136021 tagcacctta gactctgtca tttgacaaat cacagcccta attaattatt cttaaaatta 136081 tttaacattc tctctcatgc tagaccacaa gtttcatgca ggtaaggcgg agattgtgtc 136141 catttgtttg acccctttgt ctccagggcc tggtagaatg cctcatacat agtaagaatt 136201 caattaatat tttacacaga gaaaaaatta gcaacttatt taaacaaata taactgcttc 136261 agaggtaaac tgggcacatc ttagttatat tatgtgatat atgatgcttt ttgattgttt 136321 ttttaaatgt tctacaaggt agatattgtt agaggtccta agttacttga tgtgttactt 136381 gtggtgattg tattcttttc tttttattca tttaggcaga gccttaagca ccagtccata 136441 ataaaaagcc agttgaaaca caaagatata attactagct tgtgtgaaga cattcttttc 136501 tccttccatt cttgtttaca gttagctgag cagatgacac agtcagatgc acaggtaaaa 136561 tttgggctaa tagcatttta aacagcaact cttattttct ttggcagtta gtaaatctca 136621 tttgaatgtc tgggtcagtc tatttaagag gattttaatt tatttcattt gggtgttttt 136681 ttttgatctg tgggattatt tatatcccat aattactttt cacccagagc attgtattag 136741 attcctaact gctgtcattg cctctggggt ctgcctggct ccctctttgc ttggtaactg 136801 gttggtcaca gcattcttct cagaatcctt tcattctttt ctgcatgaga acaaaaattc 136861 ttttgttcat atttgtataa gatctgatat agctgcaatc aatcttgcat tttttcttca 136921 ccaacgcatt gcgaccttta gggatacaag tatgtttgtg catgtatatg tatgtatcag 136981 tcttttaaat ttgatatagt catacatttg tttttatttt gaaaagttag agtgttgaat 137041 tggtatccca tttatgaaac attatattct aaaaatttgt agtacgatta ttgggaatta 137101 taactcattt tcctgtaaca ctgttataca tagtaccttt tgctttcaga ctagccctca 137161 attttattta actatagtag tcctaaatta taagattaat agtactcagg acctaacagt 137221 tatatgtcat ttgttttttt tttttttgag atggcgtctc actctgtcac ccaagctgga 137281 gtgcagtggt atgaccttgg ctcactgcag cctctgcctc acgggttcaa gggatcgttc 137341 tgccttagcc tcctgagtag ctgggattat aggcgcctgc caccacgcct ggctaatttt 137401 tttagtagag acggggtttc gccatgttgg ccaggctggt ctcgaactcc tgacctcagg 137461 tggtccaccc gccttggcct cccaaagtgc tgggattaca ggtgtgagcc accgcgccca 137521 gcctatatgt aataatttta atgggaccat gaattgaata tttcttcctt gaatagcaat 137581 gacatagccc cttctattgt acatctgcaa gctgatacag ggaattcctt tgtacctgcg 137641 ctcttccctg ccagtcagct atgggggtga aagtgtaggg gttcatccaa gtcctaaaac 137701 tggtagcaac tcctagggca gggctgatct ggaaggacag accctagggg agggtggaac 137761 tttaaaaaga agttctgaag gtagtaagaa ggaaatgagg agtagtgtta ggaaggggct 137821 aacttttttc ttcttgcttc tcttctttat ctcacctgcc cctccccttg tatcccttct 137881 tcctttttcc ctttcctttt ttgtcctcac ttcattcgtg catcctttct gattcctctt 137941 accttgctaa aaggagaagt ttgtttgggt atcctatatc aatggcagga aggttgtttt 138001 cttctttacc tttatcctat agattcatat tctcaacacc aacctcctcc tttttcagtt 138061 tccttcttgc ttctcttgac accacagagt ttgcagctag tacttggaga ggaaaattaa 138121 acagagatac ttggaccaag agtaagatga agaaagtcta aacaacagta tagtctatag 138181 tggcaagaga gagtatgggg gctgcttagc cagggtggct gtacataaag tatatcttca 138241 gtttatataa actgcttata gatggaaatc agaaaattta aattctctta actgtccaag 138301 aaaattctca ttttttcaaa tttgggactg ataaatgtga ccagttctgc ttactgtcca 138361 ttgcctgaaa tggagctttg aggtggactg tataatttct tcaatcttaa ctccaaattc 138421 tgatcagcga cgccctctgc tgttcactat taatatttat ttaccaatca aagtaaagta 138481 ttgaagtttt cctggcagtt ttcactttgt gttttagtcc atttaggctg ctataacaaa 138541 atcccttaaa ctgggtaagg gattataaat attagaaatt tatctctcac agttctggaa 138601 gctgggaagc ccaatatcaa ggcaccagta gatttggtgt ctaacgaggg tgtgccgtct 138661 gcttcaaaaa tggccccttg ttgctgcatc ctcacttagt gcaaggggca agacagctcc 138721 cttcaacctc ttttataagg gcacttatgt cattcatgag ggcagagccc tcatgactta 138781 atcacttccc caaaggcccc acctcttaat agtatcacat tgggtgttag gtgtctggga 138841 ggacaccaat cttcaagcca tatcatctca cttggaaaaa agtcaaaata aaaccagtag 138901 atttaattaa tattacacta tttatagaag catgtgatgt atcattcctt gtattaattt 138961 cctggggttg ccgtaacaag ttaccacaaa ctaggtggct taaaacaata gaattttatt 139021 ctctcacatt tctagaggca gaagttcaca gtgtgtcaat agggccatgt tctctggaag 139081 gctttagggg agaatatatt tcatatcttt ctcttagctt ctcggtgtca ctggcaatcc 139141 ttagcttact ttggctttct gtgtcttcac atcatctttt tataagaaca ccagtgatag 139201 tgattaaggg cataccttac tttaatatga cctcatctta actaattatg tcttcaataa 139261 ccctatttcc aaataaggcc acattctgaa gtattgggag ttagaactta aagctttttg 139321 ggagggacac agttcaaccc ataacaaccc ctaaaatcga tatttattct caattaagtc 139381 ttgaaattgg tttcaaaaag agaatattct attagagttt ttaatgtata gttttaacat 139441 atagttcttt agcccccaat tttttttttt tttttttttt tttttttttt tttttgagac 139501 ggagtctcgc tctgtcgccc aggccggact gcggactgca gtggcgcaat ctcggctcac 139561 tgcaagctcc gcttcccggg ttcacgccat tcccctgcct cagcctcccg agtagctggg 139621 actacaggcg cctgccaccg cgcccggcta atttttttgt atttttagta gagacggggt 139681 ttcaccttgt tagccaggat ggtctcgatc tcctgacctc atgatccacc cgcctcggcc 139741 tcccaaagtg ctgggattac aggcgtgagc caccgcgccc ggcctgcccc caattattta 139801 gtttttctat aaacagggaa atttatttgt gtggccctta gaactaattt aatttccact 139861 ctaattccta cttatgttta tataatgctt ttagaaattt gtattattca gaaaataaac 139921 atatactatt gtatctgttg cctacactta gattttattg cctgctatat ttaaatttta 139981 ttagtatttt aattgtttta ttaaagaaag aatgtgcctg taatctcagc acttttgaga 140041 ggccaaggca gaaggattgc ttgagcccag gagtttgaga ccagactgag caacacaggg 140101 agacccccat ctctacaaaa aataaaaaaa ttctccaggc ctcatggcac atacctgtag 140161 ttctagttac ttgggagact ggggtgggag gatgcattga gcccaggaga ttgaggctgc 140221 agtgagccat gatcaggcca ctgtactcca gcttggacaa cagagtgaga gcttgtctag 140281 atagatagat agatagataa tctaaataga taatagacag attatctaaa tagataatag 140341 acagattatc taaatagata atagacagat tatctaaata gataatagac agattatcta EPI-109 948

140401 aatagataat agacagatta tctaaataga taatagacag attatctatc taaatagata

140461 atagattatc taaatagata atagatagat agattagata gatagataga tagatagagc

140521 ttggacaaca gagtgagagc ctgtctagat agatagaaac aaagaaagaa agaaagaatg

140581 gtgctcatat tttaaagcat tgaaaaatgg tcttccttgc ttatattacc cacaccttct

140641 ttgttggcat taagatgcaa actttgtttt aaacagttga gtaaatcaaa gatgggactg

140701 ttaagttatt tgtgttattt acctgctttt tgaaaatgta aaaataaaac tctaggttta

140761 attagtagta tgctatttag taatgaagta aagctagagg cttcgaacaa atcttgtgta

140821 atttcctctt gaatgagaga gaaaatttaa agtaagcaaa caaataagtt gtgtgtcacc

140881 actcattcag tcatttaaca agtatttcca gagtacttat tctgtgccag gaaatgttgt

140941 aggtgccctc aacaacttag agtctagcct gagacacaag taagtaggta attattatag

141001 aatggtatga tctttggagg actgggtatt ggctggctca tgggagtaca agataggtac

141061 ccagtgatga agtcaggaaa ggtttcttat ggtgatatga tgacgtctat gctgattata

141121 aggtcagtgt agaataaact ttgtgctttt aaatttgcat agcactgtat tagagagttc

141181 atcttcaaaa taatcgaaaa ggctgagtgt ggtgacccat ggctgtaatc ccagcacttt

141241 gggaggccga ggtgggcaga ttgcttgagc taggagttcg agaccaggct ggccaacatg

141301 gtgaaacccc gtctctacta aaaatacaaa aattagccag gagtgatggt gcgcacctgt

141361 aatgccagct acttgggagg ctgaggcagg aggatcactt gaacccagga ggtggaggtt

141421 gaagtaagcc gaggtcatgc cactgcactc cagcctgggc aacagagtga gactccatct

141481 caaaaaaaaa aaaaatgatc aaagaaaggt gaattttcat ctaccctatt tctgctgagg

141541 aaaatggact attttcaaat atttttaata agggtcaaaa tgagggatc

(2) INFORMATION FOR SEQ ID NO:2695: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear ^■

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2695

1 cctctctcgg ctagacgagc ttccccaact ggtaaccctt ccacacccca atcttcatgg

61 accagagatc ttggatgttc cttccacagt tcaaaagacc cctttcgtca cccaccctgg

121 gtatgacact ggaaatggta ttcagcttcc tggcacttct ggtcagcaac ccagtgttgg

181 gcaacaaatg atctttgagg aacatggttt taggcggacc acaccgccca caacggccac

241 ccccataagg cataggccaa gaccataccc gccgaatgta ggtgaggaaa tccaaattgg

301 tcacattccc agggaagatg tagactatca cctgtaccca cacggtccgg gactcaatcc

361 aaatgcctct acaggacaag aagctctctc tcagacaacc atctcatggg ccccattcca

421 ggacacttct gagtacatca tttcatgtca tcctgttggc actgatgaag aacccttaca

481 ggtaattaat tgttctcttc acttctcatg gggcagcaca gaaaggaata agttaggtaa

541 ctgaagtgac cagccctcga ataaaaagtg gcttcatggc cgggtgtgat ggctcacgcc

601 tgtaatccca gcactttggg aggccgaggc aggtggatca tttgaggtta ggagttcaag

661 accagcctgg ccaacatggt gaaacctcgt ctcttgaaaa aaaaaaaaaa aaagtggctc

721 caccttttag aacctcttag aagatggcac atttaagccc tgcttttttt tttttttaaa

781 tcccaatatg gctctacttt ggaggacata ccagagagtc actagccttt tatttccata

841 gagaaaatga aactatttct cttattctca cacatttgag gttccttttt gagtaagata

901 gatggttcta gaaaagaaag aaagatattc tacctgaatt tccatttgtg tgcagaagtc

961 taaaacacta cctttacgat ttgtccttga agaaccccac tatctacaac atatctaaag

1021 aaaaaaaaaa acagcgaagc tgtgcatagc ag

(2) INFORMATION FOR SEQ ID NO:2696: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single ^'

(D) TOPOLOGY: linear ■

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2696

1 atcaaacaga aatgactatt gaaggcttgc agcccacagt ggagtatgtg gttagtgtct

61 atgctcagaa tccaagcgga gagagtcagc ctctggttca gactgcagta accagtacgt

121 aaccactgct tggtttccat tttcaaagtc aaattttgtt cttgggtgtc tgaatgccca

181 cgacatgtct tttgcaatta cacataggga aagtgaactt gttggttagt ttatgtcttg

241 agctgagccc tttacgaaca tcttttttcc ttctcagtgc caagcgagga atttacagag

301 aaagaagttg tgaaaccacc atagttagtt gctgtgcttt gaatttcttt ttgctcaaat

361 ggcctcagcg aaatcttatt tgcctatagc aaatctacaa aaaattttcc tagaccgtct

421 tttctacaac tggatggtaa agttgattga agtgtgcctc atgtagcttt atgtttgggg

481 catttgaagg gctatggctg gaccagagtg taatataaat gcttaataga gaggggaaaa

541 gaagagtgta agaaccatta tagggctggg ctcacgcctg taatcccagc attttgggag

601 gctgaggcgg atcacgaggt caggagttcg agaccagcct gaccaacatg gtgaaacccc

661 atctctacta aaaatacaaa aattagccag tcgcggtggc acgtgcctgt aatcccagct

721 actcacggag gctgaggcag aagaatcact tggacccagg aggcagaagt tgcagtgagc

781 caagatcatg cctctgcacc ccagcctagg tgatagagtg agactccatc tcaaaaaaaa

841 acaaaacaaa acaattataa caatttgaat ctgaaccata tgcaaatcag ctttaccact

901 tccaaggtat aagaaaatcc aggtctatga gactaacatc acattgtaaa aatcaaatcg

961 tggtagaata cctttaaatt aatataaata catccccatt gtggggacat tttgcagggt EPI-109 949

1021 atctgcttat ctcacataca ccatgtttta ataagtgatg caacattgca tattttctaa

1081 accaagaaaa attaagcaag tgtttaagtg atttttcctt tgatagtggg ttaattggac

1141 ttcatcaaag aaaatggtat ctgcaaaact gctttgcatg ttataaaaat gcttatttca

1201 caacttgctt tcacataacc tcttaccatt aatttgccta acagacattg atcgccctaa

1261 aggactggca ttcactgatg tggatgtcga ttccatcaaa attgcttggg aaagcccaca

1321 ggggcaagtt tccaggtaca gggtgaccta ctcgagccct gaggatggaa tccatgagct

1381 attccctgca cctgatggtg aagaagacac tgcagagctg caaggcctca gaccgggttc

1441 tgagtacaca gtcagtgtgg ttgccttgca cgatgatatg gagagccagc ccctgattgg

1501 aacccagtcc acaggtatat ggttaattgc acacaggtgc catgggagca gcggctttat

1561 gcctactgaa tgaattatgc ttcactgggc tattgattcc cgtgtaaggg tgaaaaagaa

1621 ttattaggaa agatcctctt taaagaggaa tggtaagaaa caataaaact taggtgatat

1681 ttaaggaaac aagtctgatt aaaagaaatt ttggagtatc ctggcttata cacaagacca

1741 taaagcaaga catttgaaga ggatactaaa gttgtggatt atttcctaag ctctgactcc

1801 ctgtgattac cctcactatg tataaagaaa agaagtttgg cattacagag cttacttata

1861 aaaaggaacc caaactcggg catttcatag cagcatgatt ctgagcacac gtgggtaaga

1921 cctttcttct ctggttagat atcatatgct ggtgtataat tagcttaaat gattgtgatt

1981 tagacaccta ggaaataatc aatagggcaa ttgctttcca taatacttta tcttcttgtg

2041 ctttatttct gaagcagagt agaatgctaa agatgtatcc tagtgacagc ataaacccta

2101 gaggtgacag tctgtattat tgcttttcgc ttctcttttc tgcttctgtt gggagccagt

2161 tttcttctta cgccgcatta cagagagaac gtcaaattta gcaagccata tctgccatag

2221 gtccaaataa agagacaata aaaattattc tctctttttt ggatggaata ctgcgtgaaa

2281 tggttatcca tacaaagata ctttatgtag aatagaaaaa ggaggccggg tgcagtggct

2341 cacacatgta atcctagtgc tttgggaggc taagccggga gcactgattg aggccaggag

2401 ttcatgatca gcctgggcaa tgaagtgaga ccccgtctct acaaaaaaat atgaaaaaat

2461 tagcgaggtg tggtgacaca tgcctgtagt cccagctact caagaggctg aggtagagga

2521 tcacttgagc ctacgagttc aaggctgcag tgagctatga taactccact gcactgctgc

2581 ctggatgaca cagagagacc gtttctaaat taattaatta acaattttaa gaaagaaaaa

2641 gggccattgc ttatttttcc atacaaaagt aaaataaatc ataatggcca ataagccaat

2701 gtaacttttt tttttaaggg aaagcaaaac ttgtaaaacc taaaatctct tagagttttg

2761 gcatttaccc aaatgttttc agtgattctg agaattggtg gatataaaac acatttctca

2821 gcaaacactt tcttcatttt gcatccctta ctgtactttc ttgtactgaa tctttgcttg

2881 accagggaac ccacctagcc caacaagaac aatccattct acttcttgga actacgttta

2941 ttttcctttt cccccatttc ctataagata acctctaacc aatgacaatc tcgacagcta

3001 ttcctgcacc aactgacctg aagttcactc aggtcacacc cacaagcctg agcgcccagt

3061 ggacaccacc caatgttcag ctcactggat atcgagtgcg ggtgaccccc aaggagaaga

3121 ccggaccaat gaaagaagtc aaccttgctc ctgacagctc atccgtggtt gtatcaggac

3181 ttatc

(2) INFORMATION FOR SEQ ID NO: 2697: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2697

1 ctgcactttt gataacctga gtcccggcct ggagtacaat gtcagtgttt acactgtcaa

61 ggatgacaag gaaagtgtcc ctatctctga taccatcatc ccaggtaata gaaaataagc

121 tgctatcctg agagtgacat tccaataaga gtggggatta gcatcttaat ccccagatgc

181 ttaagggtgt caactatatt tgggatttaa ttccgatctc ccagctgcac tttccaaaac

241 caagaagtca aagcagcgat ttggacaaaa tgcttgctgt taacactgct ttactgtctg

301 tgcttcactg ggatgctgtg tgttgcagcg agtatgtaat ggagtggcag ccatggcttt

361 aactctgtat tgtctgctca catggaagta tgactaaaac actgtcacgt gtctgtactc

421 agtactgata ggctcaaagt aatatggtaa atgcatccca tcagtacatt tctgcccgat

481 tttacaatcc atatcaattt ccaacagctg cctatttcat cttgcagttt caaatccttc

541 tttttgaaaa ttggatttta aaaaaaagtt aagtaaaagt cacaccttca gggttgttct

601 ttcttgtggc cttgaaagac aacattgcaa aggcctgtcc taaggatagg cttgtttgtc

661 cattgggtta taacataatg aaagcattgg acagatcgtg tccccctttg gactcttcag

721 tagaatgctt ttactaacgc taattacatg ttttgattat gaatgaacct aaaatagtgg

781 caatggcctt aacctaggcc tgtctttcct cagcctgaat gtgcttttga atggcacatt

841 tcacaccata cattcataat gcattagcgt tatggccatg atgttgtcat gagttttgta

901 tgggagaaaa aaaatcaatt tatcacccat ttattatttt ttccggttgt tcatgcaagc

961 ttattttcta ctaaaacagt tttggaatta ttaaaagcat tgctgatact tacttcagat

1021 attatgtcta ggctctaaga atggtttcga catcctaaac agccatatga tttttaggaa

1081 tctgaacagt tcaaattgta ccctttaagg atgttttcaa aatgtaaaaa atatatatat

1141 atatatatat tccctaaaag aatattcctg tttattcttc tagggaagca aactgttcat

1201 gatgcttagg aagtcttttc agagaattta aaacagattg catattacca tcattgcttt

1261 aacattccac caattttact actagtaacc tgatatacac tgctttattt tttcctcttt

1321 ttttccctct attttccttt tgcctccccc tccctttgct ttgtaactca atagaggtgc

1381 cccaactcac tgacctaagc tttgttgata taaccgattc aagcatcggc ctgaggtgga EPI-109 950

1441 ccccgctaaa ctcttccacc attattgggt accgcatcac agtagttgcg gcaggagaag

1501 gtatccctat ttttgaagat tttgtggact cctcagtagg atactacaca gtcacagggc

1561 tggagccggg cattgactat gatatcagcg ttatcactct cattaatggc ggcgagagtg

1621 cccctactac actgacacaa caaacgggtg aattttgaaa acttctgcgt ttgagacata

1681 gatggtgttg catgctgcca ccagttactc cggttaaata tggatgtttc atgggggaag

1741 tcagcaattg gccaaagatt cagataggtg gaattggggg gataaggaat caaatgcatc

1801 tgctaaactg attggagaaa aacacatgca atatcttcag tacactctca tttaaaccac

1861 aagtagatat aaagcctaga gaaatacaga tgtctgctct gttaaatata aaatagcaaa

1921 tgttcattca atttgaagac ctagaatttt tcttcttaaa taccaaacac gaataccaaa

1981 ttgcgtaagt accaattgat aagaatatat caccaaaatg taccatcatg ctcttccttc

2041 taccctttga taaactctac catgctcctt ctttgtagct aaaaacccat caaaatttag

2101 ggtagagtgg atgggcattg ttttgaggta ggagaaaagt aaacttggga ccattctagg

2161 ttttgttgct gtcactaggt aaagaaacac ctctttaacc acagtctggg gacaagcatg

2221 caacatttta aaggttctct gctgtgcatg ggaaaagaaa catgctgaga accaatttgc

2281 atgaacatgt tcacttgtaa gtagaattca ctgaatggaa ctgtagctct agatatctca

2341 catgggggga agtttaggac cctcttgtct ttttgtctgt gtgcatgtat ttctttgtaa

2401 agtactgcta tgtttctctt tgctgtgtgg caacttaagc ctcttcggcc tgggataaaa

2461 taatctgcag tggtattaat aatgtacata aagtcaacat atttgaaagt agattaaaat

2521 cttttttaaa tatatcaatg atggcaaaaa ggttaaaggg ggcctaacag tactgtgtgt

2581 agtgttttat ttttaacagt agtacactat aacttaaaat agacttagat tagactgttt

2641 gcatgattat gattctgttt cctttatgca tgaaatattg attttacctt tccagctact

2701 tcgttagctt taattttaaa atacattaac tgagtcttcc ttcttgttcg aaaccagctg

2761 ttcctcctcc cactgacctg cgattcacca acattggtcc agacaccatg cgtgtcacct

2821 ggg

(2) INFORMATION FOR SEQ ID NO: 2698: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2698

1 gaagagcaag aggcaggctc agcaaatggt tcagccccag tccccggtgg ctgtcagtca

61 aagcaagccc ggttgttatg acaatggaaa acactatcag ataaatcaac agtgggagcg

121 gacctaccta ggtaatgtgt tggtttgtac ttgttatgga ggaagccgag gttttaactg

181 cgaaagtaaa cctgaagctg aagagacttg ctttgacaag tacactggga acacttaccg

241 agtgggtgac acttatgagc gtcctaaaga ctccatgatc tgggactgta cctgcatcgg

301 ggctgggcga gggagaataa gctgtaccat cgcaaaccgc tgccatgaag ggggtcagtc

361 ctacaagatt ggtgacacct ggaggagacc acatgagact ggtggttaca tgttagagtg

421 tgtgtgtctt ggtaatggaa aaggagaatg gacctgcaag cccatagctg agaagtgttt

481 tgatcatgct gctgggactt cctatgtggt cggagaaacg tgggagaagc cctaccaagg

541 ctggatgatg gtagattgta cttgcctggg agaaggcagc ggacgcatca cttgcacttc

601 tagaaataga tgcaacgatc aggacacaag gacatcctat agaattggag acacctggag

661 caagaaggat aatcgaggaa acctgctcca gtgcatctgc acaggcaacg gccgaggaga

721 gtggaagtgt gagaggcaca cctctgtgca gaccacatcg agcggatctg gccccttcac

781 cgatgttcgt gcagctgttt accaaccgca gcctcacccc cagcctcctc cctatggcca

841 ctgtgtcaca gacagtggtg tggtctactc tgtggggatg cagtggttga agacacaagg

901 aaataagcaa atgctttgca cgtgcctggg caacggagtc agctgccaag agacagctgt

961 aacccagact tacggtggca acttaaatgg agagccatgt gtcttaccat tcacctacaa

1021 tggcaggacg ttctactcct gcaccacgga agggcgacag gacggacatc tttggtgcag

1081 cacaacttcg aattatgagc aggaccagaa atactctttc tgcacagacc acactgtttt

1141 ggttcagact caaggaggaa attccaatgg tgccttgtgc cacttcccct tcctatacaa

1201 caaccacaat tacactgatt gcacttctga gggcagaaga gacaacatga agtggtgtgg

1261 gaccacacag aactatgatg ccgaccagaa gtttgggttc tgccccatgg ctgcccacga

1321 ggaaatctgc acaaccaatg aaggggtcat gtaccgcatt ggagatcagt gggataagca

1381 gcatgacatg ggtcacatga tgaggtgcac gtgtgttggg aatggtcgtg gggaatggac

1441 atgcattgcc tactcgcaac ttcgagatca gtgcattgtt gatgacatca cttacaatgt

1501 gaacgacaca ttccacaagc gtcatgaaga ggggcacatg ctgaactgta catgcttcgg

1561 tcagggtcgg ggcaggtgga agtgtgatcc cgtcgaccaa tgccaggatt cagagactgg

1621 gacgttttat caaattggag attcatggga gaagtatgtg catggtgtca gataccagtg

1681 ctactgctat ggccgtggca ttggggagtg gcattgccaa cctttacaga cctatccaag

1741 ctcaagtggt cctgtcgaag tatttatcac tgagactccg agtcagccca actcccaccc

1801 catccagtgg aatgcaccac agccatctca catttccaag tacattctca ggtggagacc

1861 taaaaattct gtaggccgtt ggaaggaagc taccatacca ggccacttaa actcctacac

1921 catcaaaggc ctgaagcctg gtgtggtata cgagggccag ctcatcagca tccagcagta

1981 cggccaccaa gaagtgact^'c gctttgactt caccaccacc agcaccagca cacctgtgac

2041 cagcaacacc gtgacaggag agacgactcc cttttctcct cttgtggcca cttctgaatc

2101 tgtgaccgaa atcacagcca gtagctttgt ggtctcctgg gtctcagctt ccgacaccgt

2161 gtcgggattc cgggtggaat atgagctgag tgaggaggga gatgagccac agtacctgga EPI-109 9S1

2221 tcttccaagc acagccactt ctgtgaacat ccctgacctg cttcctggcc gaaaatacat

2281 tgtaaatgtc tatcagatat ctgaggatgg ggagcagagt ttgatcctgt ctacttcaca

2341 aacaacagcg cctgatgccc ctcctgaccc gactgtggac caagttgatg acacctcaat

2401 tgttgttcgc tggagcagac cccaggctcc catcacaggg tacagaatag tctattcgcc

2461 atcagtagaa ggtagcagca cagaactcaa ccttcctgaa actgcaaact ccgtcaccct

2521 cagtgacttg caacctggtg ttcagtataa catcactatc tatgctgtgg aagaaaatca

2581 agaaagtaca cctgttgtca ttcaacaaga aaccactggc accccacgct cagatacagt

2641 gccctctccc agggacctgc agtttgtgga agtgacagac gtgaaggtca ccatcatgtg 2701 gacaccgcct gagagtgcag tgaccggcta ccgtgtggat gtgatccccg tcaacctgcc 2761 tggcgagcac gggcagaggc tgcccatcag caggaacacc tttgcagaag tcaccgggct 2821 gtcccctggg gtcacctatt acttcaaagt ctttgcagtg agccatggga gggagagcaa 2881 gcctctgact gctcaacaga caaccaaact ggatgctccc actaacctcc agtttgtcaa 2941 tgaaactgat tctactgtcc tggtgagatg gactccacct cgggcccaga taacaggata 3001 ccgactgacc gtgggcctta cccgaagagg ccagcccagg cagtacaatg tgggtccctc 3061 tgtctccaag taccccctga ggaatctgca gcctgcatct gagtacaccg tatccctcgt 3121 ggccataaag ggcaaccaag agagccccaa agccactgga gtctttacca cactgcagcc 3181 tgggagctct attccacctt acaacaccga ggtgactgag accaccatcg tgatcacatg 3241 gacgcctgct ccaagaattg gttttaagct gggtgtacga ccaagccagg gaggagaggc 3301 accacgagaa gtgacttcag actcaggaag catcgttgtg tccggcttga ctccaggagt 3361 agaatacgtc tacaccatcc aagtcctgag agatggacag gaaagagatg cgccaattgt 3421 aaacaaagtg gtgacaccat tgtctccacc aacaaacttg catctggagg caaaccctga 3481 cactggagtg ctcacagtct cctgggagag gagcaccacc ccagacatta ctggttatag 3541 aattaccaca acccctacaa acggccagca gggaaattct ttggaagaag tggtccatgc

3601 tgatcagagc tcctgcactt ttgataacct gagtcccggc ctggagtaca atgtcagtgt 3661 ttacactgtc aaggatgaca aggaaagtgt ccctatctct gataccatca tcccagctgt 3721 tcctcctccc actgacctgc gattcaccaa cattggtcca gacaccatgc gtgtcacctg 3781 ggctccaccc ccatccattg atttaaccaa cttcctggtg cgttactcac ctgtgaaaaa 3841 tgaggaagat gttgcagagt tgtcaatttc tccttcagac aatgcagtgg tcttaacaaa 3901 tctcctgcct ggtacagaat atgtagtgag tgtctccagt gtctacgaac aacatgagag 3961 cacacctctt agaggaagac agaaaacagg tcttgattcc ccaactggca ttgacttttc 4021 tgatattact gccaactctt ttactgtgca ctggattgct cctcgagcca ccatcactgg 4081 ctacaggatc cgccatcatc ccgagcactt cagtgggaga cctcgagaag atcgggtgcc 4141 ccactctcgg aattccatca ccctcaccaa cctcactcca ggcacagagt atgtggtcag 4201 catcgttgct cttaatggca gagaggaaag tcccttattg attggccaac aatcaacagt 4261 ttctgatgtt ccgagggacc tggaagttgt tgctgcgacc cccaccagcc tactgatcag 4321 ctgggatgct cctgctgtca cagtgagata ttacaggatc acttacggag aaacaggagg 4381 aaatagccct gtccaggagt tcactgtgcc tgggagcaag tctacagcta ccatcagcgg 4441 ccttaaacct ggagttgatt ataccatcac tgtgtatgct gtcactggcc gtggagacag 4501 ccccgcaagc agcaagccaa tttccattaa ttaccgaaca gaaattgaca aaccatccca 4561 gatgcaagtg accgatgttc aggacaacag cattagtgtc aagtggctgc cttcaagttc

4621 ccctgttact ggttacagag taaccaccac tcccaaaaat ggaccaggac caacaaaaac 4681 taaaactgca ggtccagatc aaacagaaat gactattgaa ggcttgcagc ccacagtgga 4741 gtatgtggtt agtgtctatg ctcagaatcc aagcggagag agtcagcctc tggttcagac 4801 tgcagtaacc aacattgatc gccctaaagg actggcattc actgatgtgg atgtcgattc 4861 catcaaaatt gcttgggaaa gcccacaggg gcaagtttcc aggtacaggg tgacctactc 4921 gagccctgag gatggaatcc atgagctatt ccctgcacct gatggtgaag aagacactgc 4981 agagctgcaa ggcctcagac cgggttctga gtacacagtc agtgtggttg ccttgcacga 5041 tgatatggag agccagcccc tgattggaac ccagtccaca gctattcctg caccaactga 5101 cctgaagttc actcaggtca cacccacaag cctgagcgcc cagtggacac cacccaatgt 5161 tcagctcact ggatatcgag tgcgggtgac ccccaaggag aagaccggac caatgaaaga 5221 aatcaacctt gctcctgaca gctcatccgt ggttgtatca ggacttatgg tggccaccaa 5281 atatgaagtg agtgtctatg ctcttaagga cactttgaca agcagaccag ctcagggtgt 5341 tgtcaccact ctggagaatg tcagcccacc aagaagggct cgtgtgacag atgctactga 5401 gaccaccatc accattagct ggagaaccaa gactgagacg atcactggct tccaagttga 5461 tgccgttcca gccaatggcc agactccaat ccagagaacc atcaagccag atgtcagaag 5521 ctacaccatc acaggtttac aaccaggcac tgactacaag atctacctgt acaccttgaa 5581 tgacaatgct cggagctccc ctgtggtcat cgacgcctcc actgccattg atgcaccatc 5641 caacctgcgt ttcctggcca ccacacccaa ttccttgctg gtatcatggc agccgccacg 5701 tgccaggatt accggctaca tcatcaagta tgagaagcct gggtctcctc ccagagaagt 5761 ggtccctcgg ccccgccctg gtgtcacaga ggctactatt actggcctgg aaccgggaac 5821 cgaatataca atttatgtca ttgccctgaa gaataatcag aagagcgagc ccctgattgg 5881 aaggaaaaag acagacgagc ttccccaact ggtaaccctt ccacacccca atcttcatgg 5941 accagagatc ttggatgttc cttccacagt tcaaaagacc cctttcgtca cccaccctgg 6001 gtatgacact ggaaatggta ttcagcttcc tggcacttct ggtcagcaac ccagtgttgg 6061 gcaacaaatg atctttgagg aacatggttt taggcggacc acaccgccca caacggccac 6121 ccccataagg cataggccaa gaccataccc gccgaatgta ggacaagaag ctctctctca 6181 gacaaccatc tcatgggccc cattccagga cacttctgag tacatcattt catgtcatcc 6241 tgttggcact gatgaagaac ccttacagtt cagggttcct ggaacttcta ccagtgccac EPI-109 952

6301 tctgacaggc ctcaccagag gtgccaccta caacatcata gtggaggcac tgaaagacca

6361 gcagaggcat aaggttcggg aagaggttgt taccgtgggc aactctgtca acgaaggctt

6421 gaaccaacct acggatgact cgtgctttga cccctacaca gtttcccatt atgccgttgg

6481 agatgagtgg gaacgaatgt ctgaatcagg ctttaaactg ttgtgccagt gcttaggctt

6541 tggaagtggt catttcagat gtgattcatc tagatggtgc catgacaatg gtgtgaacta

6601 caagattgga gagaagtggg accgtcaggg agaaaatggc cagatgatga gctgcacatg

6661 tcttgggaac ggaaaaggag aattcaagtg tgaccctcat gaggcaacgt gttacgatga

6721 tgggaagaca taccacgtag gagaacagtg gcagaaggaa tatctcggtg ccatttgctc

6781 ctgcacatgc tttggaggcc agcggggctg gcgctgtgac aactgccgca gacctggggg

6841 tgaacccagt cccgaaggca ctactggcca gtcctacaac cagtattctc agagatacca

6gθl tcagagaaca aacactaatg ttaattgccc aattgagtgc ttcatgcctt tagatgtaca

6961 ggctgacaga gaagattccc gagagtaaat catctttcca atccagagga acaagcatgt

7021 ctctctgcca agatccatct aaactggagt gatgttagca gacccagctt agagttcttc

7081 tttctttctt aagccctttg ctctggagga agttctccag cttcagctca actcacagct

7141 tctccaagca tcaccctggg agtttcctga gggttttctc ataaatgagg gctgcacatt

7201 gcctgttctg cttcgaagta ttcaataccg ctcagtattt taaatgaagt gattctaaga

7261 tttggtttgg gatcaatagg aaagcatatg cagccaacca agatgcaaat gttttgaaat

7321 gatatgacca aaattttaag taggaaagtc acccaaacac ttctgctttc acttaagtgt

7381 ctggcccgca atactgtagg aacaagcatg atcttgttac tgtgatattt taaatatcca

7441 cagtactcac tttttccaaa tgatcctagt aattgcctag aaatatcttt ctcttacctg

7501 ttatttatca atttttccca gtatttttat acggaaaaaa ttgtattgaa aacacttagt

7561 atgcagttga taagaggaat ttggtataat tatggtgggt gattattttt tatactgtat

7621 gtgccaaagc tttactactg tggaaagaca actgttttaa taaaagattt acattccaca

(2) INFORMATION FOR SEQ ID NO:2699: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2699

1 cctctctcgg ctagacgagc ttccccaact ggtaaccctt ccacacccca atcttcatgg 61 accagagatc ttggatgttc cttccacagt tcaaaagacc cctttcgtca cccaccctgg 121 gtatgacact ggaaatggta ttcagcttcc tggcacttct ggtcagcaac ccagtgttgg 181 gcaacaaatg atctttgagg aacatggttt taggcggacc acaccgccca caacggccac 241 ccccataagg cataggccaa gaccataccc gccgaatgta ggtgaggaaa tccaaattgg 301 tcacattccc agggaagatg tagactatca cctgtaccca cacggtccgg gactcaatcc 361 aaatgcctct acaggacaag aagctctctc tcagacaacc atctcatggg ccccattcca 421 ggacacttct gagtacatca tttcatgtca tcctgttggc actgatgaag aacccttaca 481 ggtaattaat tgttctcttc acttctcatg gggcagcaca gaaaggaata agttaggtaa 541 ctgaagtgac cagccctcga ataaaaagtg gcttcatggc cgggtgtgat ggctcacgcc 601 tgtaatccca gcactttggg aggccgaggc aggtggatca tttgaggtta ggagttcaag 661 accagcctgg ccaacatggt gaaacctcgt ctcttgaaaa aaaaaaaaaa aaagtggctc 721 caccttttag aacctcttag aagatggcac atttaagccc tgcttttttt tttttttaaa 781 tcccaatatg gctctacttt ggaggacata ccagagagtc actagccttt tatttccata 841 gagaaaatga aactatttct cttattctca cacatttgag gttccttttt gagtaagata 901 gatggttcta gaaaagaaag aaagatattc tacctgaatt tccatttgtg tgcagaagtc 961 taaaacacta cctttacgat ttgtccttga agaaccccac tatctacaac atatctaaag 1021 aaaaaaaaaa acagcgaagc tgtgcatagc ag

1 atcaaacaga aatgactatt gaaggcttgc agcccacagt ggagtatgtg gttagtgtct

61 atgctcagaa tccaagcgga gagagtcagc ctctggttca gactgcagta accagtacgt

121 aaccactgct tggtttccat tttcaaagtc aaattttgtt cttgggtgtc tgaatgccca

181 cgacatgtct tttgcaatta cacataggga aagtgaactt gttggttagt ttatgtcttg

241 agctgagccc tttacgaaca tcttttttcc ttctcagtgc caagcgagga atttacagag

301 aaagaagttg tgaaaccacc atagttagtt gctgtgcttt gaatttcttt ttgctcaaat

361 ggcctcagcg aaatcttatt tgcctatagc aaatctacaa aaaattttcc tagaccgtct

421 tttctacaac tggatggtaa agttgattga agtgtgcctc atgtagcttt atgtttgggg

481 catttgaagg gctatggctg gaccagagtg taatataaat gcttaataga gaggggaaaa

541 gaagagtgta agaaccatta tagggctggg ctcacgcctg taatcccagc attttgggag

601 gctgaggcgg atcacgaggt caggagttcg agaccagcct gaccaacatg gtgaaacccc

661 atctctacta aaaatacaaa aattagccag tcgcggtggc acgtgcctgt aatcccagct

721 actcacggag gctgaggcag aagaatcact tggacccagg aggcagaagt tgcagtgagc

781 caagatcatg cctctgcacc ccagcctagg tgatagagtg agactccatc tcaaaaaaaa

841 acaaaacaaa acaattataa caatttgaat ctgaaccata tgcaaatcag ctttaccact

901 tccaaggtat aagaaaatcc aggtctatga gactaacatc acattgtaaa aatcaaatcg

961 tggtagaata cctttaaatt aatataaata catccccatt gtggggacat tttgcagggt

1021 atctgcttat ctcacataca ccatgtttta ataagtgatg caacattgca tattttctaa

1081 accaagaaaa attaagcaag tgtttaagtg atttttcctt tgatagtggg ttaattggac

1141 ttcatcaaag aaaatggtat ctgcaaaact gctttgcatg ttataaaaat gcttatttca EPI-109 953

1201 caacttgctt tcacataacc tcttaccatt aatttgccta acagacattg atcgccctaa

1261 aggactggca ttcactgatg tggatgtcga ttccatcaaa attgcttggg aaagcccaca

1321 ggggcaagtt tccaggtaca gggtgaccta ctcgagccct gaggatggaa tccatgagct

1381 attccctgca cctgatggtg aagaagacac tgcagagctg caaggcctca gaccgggttc

1441 tgagtacaca gtcagtgtgg ttgccttgca cgatgatatg gagagccagc ccctgattgg

1501 aacccagtcc acaggtatat ggttaattgc acacaggtgc catgggagca gcggctttat

1561 gcctactgaa tgaattatgc ttcactgggc tattgattcc cgtgtaaggg tgaaaaagaa

1621 ttattaggaa agatcctctt taaagaggaa tggtaagaaa caataaaact taggtgatat

1681 ttaaggaaac aagtctgatt aaaagaaatt ttggagtatc ctggcttata cacaagacca

1741 taaagcaaga catttgaaga ggatactaaa gttgtggatt atttcctaag ctctgactcc

1801 ctgtgattac cctcactatg tataaagaaa agaagtttgg cattacagag cttacttata

1861 aaaaggaacc caaactcggg catttcatag cagcatgatt ctgagcacac gtgggtaaga

1921 cctttcttct ctggttagat atcatatgct ggtgtataat tagcttaaat gattgtgatt

1981 tagacaccta ggaaataatc aatagggcaa ttgctttcca taatacttta tcttcttgtg

2041 ctttatttct gaagcagagt agaatgctaa agatgtatcc tagtgacagc ataaacccta

2101 gaggtgacag tctgtattat tgcttttcgc ttctcttttc tgcttctgtt gggagccagt

2161 tttcttctta cgccgcatta cagagagaac gtcaaattta gcaagccata tctgccatag

2221 gtccaaataa agagacaata aaaattattc tctctttttt ggatggaata ctgcgtgaaa

2281 tggttatcca tacaaagata ctttatgtag aatagaaaaa ggaggccggg tgcagtggct

2341 cacacatgta atcctagtgc tttgggaggc taagccggga gcactgattg aggccaggag

2401 ttcatgatca gcctgggcaa tgaagtgaga ccccgtctct acaaaaaaat atgaaaaaat

2461 tagcgaggtg tggtgacaca tgcctgtagt cccagctact caagaggctg aggtagagga

2521 tcacttgagc ctacgagttc aaggctgcag tgagctatga taactccact gcactgctgc

2581 ctggatgaca cagagagacc gtttctaaat taattaatta acaattttaa gaaagaaaaa

2641 gggccattgc ttatttttcc atacaaaagt aaaataaatc ataatggcca ataagccaat

2701 gtaacttttt tttttaaggg aaagcaaaac ttgtaaaacc taaaatctct tagagttttg

2761 gcatttaccc aaatgttttc agtgattctg agaattggtg gatataaaac acatttctca

2821 gcaaacactt tcttcatttt gcatccctta ctgtactttc ttgtactgaa tctttgcttg

2881 accagggaac ccacctagcc caacaagaac aatccattct acttcttgga actacgttta

2941 ttttcctttt cccccatttc ctataagata acctctaacc aatgacaatc tcgacagcta

3001 ttcctgcacc aactgacctg aagttcactc aggtcacacc cacaagcctg agcgcccagt

3061 ggacaccacc caatgttcag ctcactggat atcgagtgcg ggtgaccccc aaggagaaga

3121 ccggaccaat gaaagaagtc aaccttgctc ctgacagctc atccgtggtt gtatcaggac

3181 ttatc

1 ctgcactttt gataacctga gtcccggcct ggagtacaat gtcagtgttt acactgtcaa

61 ggatgacaag gaaagtgtcc ctatctctga taccatcatc ccaggtaata gaaaataagc

121 tgctatcctg agagtgacat tccaataaga gtggggatta gcatcttaat ccccagatgc

181 ttaagggtgt caactatatt tgggatttaa ttccgatctc ccagctgcac tttccaaaac

241 caagaagtca aagcagcgat ttggacaaaa tgcttgctgt taacactgct ttactgtctg

301 tgcttcactg ggatgctgtg tgttgcagcg agtatgtaat ggagtggcag ccatggcttt

361 aactctgtat tgtctgctca catggaagta tgactaaaac actgtcacgt gtctgtactc

421 agtactgata ggctcaaagt aatatggtaa atgcatccca tcagtacatt tctgcccgat

481 tttacaatcc atatcaattt ccaacagctg cctatttcat cttgcagttt caaatccttc

541 tttttgaaaa ttggatttta aaaaaaagtt aagtaaaagt cacaccttca gggttgttct

601 ttcttgtggc cttgaaagac aacattgcaa aggcctgtcc taaggatagg cttgtttgtc

661 cattgggtta taacataatg aaagcattgg acagatcgtg tccccctttg gactcttcag

721 tagaatgctt ttactaacgc taattacatg ttttgattat gaatgaacct aaaatagtgg

781 caatggcctt aacctaggcc tgtctttcct cagcctgaat gtgcttttga atggcacatt

841 tcacaccata cattcataat gcattagcgt tatggccatg atgttgtcat gagttttgta

901 tgggagaaaa aaaatcaatt tatcacccat ttattatttt ttccggttgt tcatgcaagc

961 ttattttcta ctaaaacagt tttggaatta ttaaaagcat tgctgatact tacttcagat

1021 attatgtcta ggctctaaga atggtttcga catcctaaac agccatatga tttttaggaa

1081 tctgaacagt tcaaattgta ccctttaagg atgttttcaa aatgtaaaaa atatatatat

1141 atatatatat tccctaaaag aatattcctg tttattcttc tagggaagca aactgttcat

1201 gatgcttagg aagtcttttc agagaattta aaacagattg catattacca tcattgcttt

1261 aacattccac caattttact actagtaacc tgatatacac tgctttattt tttcctcttt

1321 ttttccctct attttccttt tgcctccccc tccctttgct ttgtaactca atagaggtgc

1381 cccaactcac tgacctaagc tttgttgata taaccgattc aagcatcggc ctgaggtgga

1441 ccccgctaaa ctcttccacc attattgggt accgcatcac agtagttgcg gcaggagaag

1501 gtatccctat ttttgaagat tttgtggact cctcagtagg atactacaca gtcacagggc

1561 tggagccggg cattgactat gatatcagcg ttatcactct cattaatggc ggcgagagtg

1621 cccctactac actgacacaa caaacgggtg aattttgaaa acttctgcgt ttgagacata

1681 gatggtgttg catgctgcca ccagttactc cggttaaata tggatgtttc atgggggaag

1741 tcagcaattg gccaaagatt cagataggtg gaattggggg gataaggaat caaatgcatc

1801 tgctaaactg attggagaaa aacacatgca atatcttcag tacactctca tttaaaccac

1861 aagtagatat aaagcctaga gaaatacaga tgtctgctct gttaaatata aaatagcaaa

1921 tgttcattca atttgaagac ctagaatttt tcttcttaaa taccaaacac gaataccaaa

1981 ttgcgtaagt accaattgat aagaatatat caccaaaatg taccatcatg ctcttccttc EPI-109 954

2041 taccctttga taaactctac catgctcctt ctttgtagct aaaaacccat caaaatttag

2101 ggtagagtgg atgggcattg ttttgaggta ggagaaaagt aaacttggga ccattctagg

2161 ttttgttgct gtcactaggt aaagaaacac ctctttaacc acagtctggg gacaagcatg

2221 caacatttta aaggttctct gctgtgcatg ggaaaagaaa catgctgaga accaatttgc

2281 atgaacatgt tcacttgtaa gtagaattca ctgaatggaa ctgtagctct agatatctca

2341 catgggggga agtttaggac cctcttgtct ttttgtctgt gtgcatgtat ttctttgtaa

2401 agtactgcta tgtttctctt tgctgtgtgg caacttaagc ctcttcggcc tgggataaaa

2461 taatctgcag tggtattaat aatgtacata aagtcaacat atttgaaagt agattaaaat

2521 cttttttaaa tatatcaatg atggcaaaaa ggttaaaggg ggcctaacag tactgtgtgt

2581 agtgttttat ttttaacagt agtacactat aacttaaaat agacttagat tagactgttt

2641 gcatgattat gattctgttt cctttatgca tgaaatattg attttacctt tccagctact

2701 tcgttagctt taattttaaa atacattaac tgagtcttcc ttcttgttcg aaaccagctg

2761 ttcctcctcc cactgacctg cgattcacca acattggtcc agacaccatg cgtgtcacct

2821 ggg

1 gaagagcaag aggcaggctc agcaaatggt tcagccccag tccccggtgg ctgtcagtca

61 aagcaagccc ggttgttatg acaatggaaa acactatcag ataaatcaac agtgggagcg

121 gacctaccta ggtaatgtgt tggtttgtac ttgttatgga ggaagccgag gttttaactg

181 cgaaagtaaa cctgaagctg aagagacttg ctttgacaag tacactggga acacttaccg

241 agtgggtgac acttatgagc gtcctaaaga ctccatgatc tgggactgta cctgcatcgg

301 ggctgggcga gggagaataa gctgtaccat cgcaaaccgc tgccatgaag ggggtcagtc

361 ctacaagatt ggtgacacct ggaggagacc acatgagact ggtggttaca tgttagagtg

421 tgtgtgtctt ggtaatggaa aaggagaatg gacctgcaag cccatagctg agaagtgttt

481 tgatcatgct gctgggactt cctatgtggt cggagaaacg tgggagaagc cctaccaagg

541 ctggatgatg gtagattgta cttgcctggg agaaggcagc ggacgcatca cttgcacttc

601 tagaaataga tgcaacgatc aggacacaag gacatcctat agaattggag acacctggag

661 caagaaggat aatcgaggaa acctgctcca gtgcatctgc acaggcaacg gccgaggaga

721 gtggaagtgt gagaggcaca cctctgtgca gaccacatcg agcggatctg gccccttcac

781 cgatgttcgt gcagctgttt accaaccgca gcctcacccc cagcctcctc cctatggcca

841 ctgtgtcaca gacagtggtg tggtctactc tgtggggatg cagtggttga agacacaagg

901 aaataagcaa atgctttgca cgtgcctggg caacggagtc agctgccaag agacagctgt

961 aacccagact tacggtggca acttaaatgg agagccatgt gtcttaccat tcacctacaa

1021 tggcaggacg ttctactcct gcaccacgga agggcgacag gacggacatc tttggtgcag

1081 cacaacttcg aattatgagc aggaccagaa atactctttc tgcacagacc acactgtttt

1141 ggttcagact caaggaggaa attccaatgg tgccttgtgc cacttcccct tcctatacaa

1201 caaccacaat tacactgatt gcacttctga gggcagaaga gacaacatga agtggtgtgg

1261 gaccacacag aactatgatg ccgaccagaa gtttgggttc tgccccatgg ctgcccacga

1321 ggaaatctgc acaaccaatg aaggggtcat gtaccgcatt ggagatcagt gggataagca

1381 gcatgacatg ggtcacatga tgaggtgcac gtgtgttggg aatggtcgtg gggaatggac

1441 atgcattgcc tactcgcaac ttcgagatca gtgcattgtt gatgacatca cttacaatgt

1501 gaacgacaca ttccacaagc gtcatgaaga ggggcacatg ctgaactgta catgcttcgg

1561 tcagggtcgg ggcaggtgga agtgtgatcc cgtcgaccaa tgccaggatt cagagactgg

1621 gacgttttat caaattggag attcatggga gaagtatgtg catggtgtca gataccagtg

1681 ctactgctat ggccgtggca ttggggagtg gcattgccaa cctttacaga cctatccaag

1741 ctcaagtggt cctgtcgaag tatttatcac tgagactccg agtcagccca actcccaccc

1801 catccagtgg aatgcaccac agccatctca catttccaag tacattctca ggtggagacc

1861 taaaaattct gtaggccgtt ggaaggaagc taccatacca ggccacttaa actcctacac

1921 catcaaaggc ctgaagcctg gtgtggtata cgagggccag ctcatcagca tccagcagta

1981 cggccaccaa gaagtgactc gctttgactt caccaccacc agcaccagca cacctgtgac

2041 cagcaacacc gtgacaggag agacgactcc cttttctcct cttgtggcca cttctgaatc

2101 tgtgaccgaa atcacagcca gtagctttgt ggtctcctgg gtctcagctt ccgacaccgt

2161 gtcgggattc cgggtggaat atgagctgag tgaggaggga gatgagccac agtacctgga

2221 tcttccaagc acagccactt ctgtgaacat ccctgacctg cttcctggcc gaaaatacat

2281 tgtaaatgtc tatcagatat ctgaggatgg ggagcagagt ttgatcctgt ctacttcaca

2341 aacaacagcg cctgatgccc ctcctgaccc gactgtggac caagttgatg acacctcaat

2401 tgttgttcgc tggagcagac cccaggctcc catcacaggg tacagaatag tctattcgcc

2461 atcagtagaa ggtagcagca cagaactcaa ccttcctgaa actgcaaact ccgtcaccct

2521 cagtgacttg caacctggtg ttcagtataa catcactatc tatgctgtgg aagaaaatca

2581 agaaagtaca cctgttgtca ttcaacaaga aaccactggc accccacgct cagatacagt

2641 gccctctccc agggacctgc agtttgtgga agtgacagac gtgaaggtca ccatcatgtg

2701 gacaccgcct gagagtgcag tgaccggcta ccgtgtggat gtgatccccg tcaacctgcc

2761 tggcgagcac gggcagaggc tgcccatcag caggaacacc tttgcagaag tcaccgggct

2821 gtcccctggg gtcacctatt acttcaaagt ctttgcagtg agccatggga gggagagcaa

2881 gcctctgact gctcaacaga caaccaaact ggatgctccc actaacctcc agtttgtcaa

2941 tgaaactgat tctactgtcc tggtgagatg gactccacct cgggcccaga taacaggata

3001 ccgactgacc gtgggcctta cccgaagagg ccagcccagg cagtacaatg tgggtccctc

3061 tgtctccaag taccccctga ggaatctgca gcctgcatct gagtacaccg tatccctcgt

3121 ggccataaag ggcaaccaag agagccccaa agccactgga gtctttacca cactgcagcc

3181 tgggagctct attccacctt acaacaccga ggtgactgag accaccatcg tgatcacatg EPI-109 955

3241 gacgcctgct ccaagaattg gttttaagct gggtgtacga ccaagccagg gaggagaggc 3301 accacgagaa gtgacttcag actcaggaag catcgttgtg tccggcttga ctccaggagt 3361 agaatacgtc tacaccatcc aagtcctgag agatggacag gaaagagatg cgccaattgt 3421 aaacaaagtg gtgacaccat tgtctccacc aacaaacttg catctggagg caaaccctga 3481 cactggagtg ctcacagtct cctgggagag gagcaccacc ccagacatta ctggttatag 3541 aattaccaca acccctacaa acggccagca gggaaattct ttggaagaag tggtccatgc 3601 tgatcagagc tcctgcactt ttgataacct gagtcccggc ctggagtaca atgtcagtgt 3661 ttacactgtc aaggatgaca aggaaagtgt ccctatctct gataccatca tcccagctgt 3721 tcctcctccc actgacctgc gattcaccaa cattggtcca gacaccatgc gtgtcacctg 3781 ggctccaccc ccatccattg atttaaccaa cttcctggtg cgttactcac ctgtgaaaaa 3841 tgaggaagat gttgcagagt tgtcaatttc tccttcagac aatgcagtgg tcttaacaaa 3901 tctcctgcct ggtacagaat atgtagtgag tgtctccagt gtctacgaac aacatgagag 3961 cacacctctt agaggaagac agaaaacagg tcttgattcc ccaactggca ttgacttttc 4021 tgatattact gccaactctt ttactgtgca ctggattgct cctcgagcca ccatcactgg 4081 ctacaggatc cgccatcatc ccgagcactt cagtgggaga cctcgagaag atcgggtgcc 4141 ccactctcgg aattccatca ccctcaccaa cctcactcca ggcacagagt atgtggtcag 4201 catcgttgct cttaatggca gagaggaaag tcccttattg attggccaac aatcaacagt 4261 ttctgatgtt ccgagggacc tggaagttgt tgctgcgacc cccaccagcc tactgatcag 4321 ctgggatgct cctgctgtca cagtgagata ttacaggatc acttacggag aaacaggagg 4381 aaatagccct gtccaggagt tcactgtgcc tgggagcaag tctacagcta ccatcagcgg 4441 ccttaaacct ggagttgatt ataccatcac tgtgtatgct gtcactggcc gtggagacag 4501 ccccgcaagc agcaagccaa tttccattaa ttaccgaaca gaaattgaca aaccatccca 4561 gatgcaagtg accgatgttc aggacaacag cattagtgtc aagtggctgc cttcaagttc 4621 ccctgttact ggttacagag taaccaccac tcccaaaaat ggaccaggac caacaaaaac 4681 taaaactgca ggtccagatc aaacagaaat gactattgaa ggcttgcagc ccacagtgga 4741 gtatgtggtt agtgtctatg ctcagaatcc aagcggagag agtcagcctc tggttcagac 4801 tgcagtaacc aacattgatc gccctaaagg actggcattc actgatgtgg atgtcgattc 4861 catcaaaatt gcttgggaaa gcccacaggg gcaagtttcc aggtacaggg tgacctactc 4921 gagccctgag gatggaatcc atgagctatt ccctgcacct gatggtgaag aagacactgc 4981 agagctgcaa ggcctcagac cgggttctga gtacacagtc agtgtggttg ccttgcacga 5041 tgatatggag agccagcccc tgattggaac ccagtccaca gctattcctg caccaactga 5101 cctgaagttc actcaggtca cacccacaag cctgagcgcc cagtggacac cacccaatgt 5161 tcagctcact ggatatcgag tgcgggtgac ccccaaggag aagaccggac caatgaaaga 5221 aatcaacctt gctcctgaca gctcatccgt ggttgtatca ggacttatgg tggccaccaa 5281 atatgaagtg agtgtctatg ctcttaagga cactttgaca agcagaccag ctcagggtgt 5341 tgtcaccact ctggagaatg tcagcccacc aagaagggct cgtgtgacag atgctactga 5401 gaccaccatc accattagct ggagaaccaa gactgagacg atcactggct tccaagttga 5461 tgccgttcca gccaatggcc agactccaat ccagagaacc atcaagccag atgtcagaag 5521 ctacaccatc acaggtttac aaccaggcac tgactacaag atctacctgt acaccttgaa 5581 tgacaatgct cggagctccc ctgtggtcat cgacgcctcc actgccattg atgcaccatc 5641 caacctgcgt ttcctggcca ccacacccaa ttccttgctg gtatcatggc agccgccacg 5701 tgccaggatt accggctaca tcatcaagta tgagaagcct gggtctcctc ccagagaagt 5761 ggtccctcgg ccccgccctg gtgtcacaga ggctactatt actggcctgg aaccgggaac 5821 cgaatataca atttatgtca ttgccctgaa gaataatcag aagagcgagc ccctgattgg 5881 aaggaaaaag acagacgagc ttccccaact ggtaaccctt ccacacccca atcttcatgg 5941 accagagatc ttggatgttc cttccacagt tcaaaagacc cctttcgtca cccaccctgg 6001 gtatgacact ggaaatggta ttcagcttcc tggcacttct ggtcagcaac ccagtgttgg 6061 gcaacaaatg atctttgagg aacatggttt taggcggacc acaccgccca caacggccac 6121 ccccataagg cataggccaa gaccataccc gccgaatgta ggacaagaag ctctctctca 6181 gacaaccatc tcatgggccc cattccagga cacttctgag tacatcattt catgtcatcc 6241 tgttggcact gatgaagaac ccttacagtt cagggttcct ggaacttcta ccagtgccac 6301 tctgacaggc ctcaccagag gtgccaccta caacatcata gtggaggcac tgaaagacca 6361 gcagaggcat aaggttcggg aagaggttgt taccgtgggc aactctgtca acgaaggctt 6421 gaaccaacct acggatgact cgtgctttga cccctacaca gtttcccatt atgccgttgg 6481 agatgagtgg gaacgaatgt ctgaatcagg ctttaaactg ttgtgccagt gcttaggctt 6541 tggaagtggt catttcagat gtgattcatc tagatggtgc catgacaatg gtgtgaacta 6601 caagattgga gagaagtggg accgtcaggg agaaaatggc cagatgatga gctgcacatg 6661 tcttgggaac ggaaaaggag aattcaagtg tgaccctcat gaggcaacgt gttacgatga 6721 tgggaagaca taccacgtag gagaacagtg gcagaaggaa tatctcggtg ccatttgctc 6781. ctgcacatgc tttggaggcc agcggggctg gcgctgtgac aactgccgca gacctggggg 6841 tgaacccagt cccgaaggca ctactggcca gtcctacaac cagtattctc agagatacca 6901 tcagagaaca aacactaatg ttaattgccc aattgagtgc ttcatgcctt tagatgtaca 6 61 ggctgacaga gaagattccc gagagtaaat catctttcca atccagagga acaagcatgt 7021 ctctctgcca agatccatct aaactggagt gatgttagca gacccagctt agagttcttc 7081 tttctttctt aagccctttg ctctggagga agttctccag cttcagctca actcacagct 7141 tctccaagca tcaccctggg agtttcctga gggttttctc ataaatgagg gctgcacatt 7201 gcctgttctg cttcgaagta ttcaataccg ctcagtattt taaatgaagt gattctaaga 7261 tttggtttgg gatcaatagg aaagcatatg cagccaacca agatgcaaat gttttgaaat EPI-109 956

7321 gatatgacca aaattttaag taggaaagtc acccaaacac ttctgctttc acttaagtgt 7381 ctggcccgca atactgtagg aacaagcatg atcttgttac tgtgatattt taaatatcca 7441 cagtactcac tttttccaaa tgatcctagt aattgcctag aaatatcttt ctcttacctg 7501 ttatttatca atttttccca gtatttttat acggaaaaaa ttgtattgaa aacacttagt 7561 atgcagttga taagaggaat ttggtataat tatggtgggt gattattttt tatactgtat 7621 gtgccaaagc tttactactg tggaaagaca actgttttaa taaaagattt acattccaca

(2) INFORMATION FOR SEQ ID NO: 2700: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2700

1 ctgctcctgc gcggcagctg ctttagaagg tctcgagcct cctgtacctt cccagggatg

61 aaccgggcct tccctctgga aggcgagggt tcgggccaca gtgagcgagg gccagggcgg

121 tgggcgcgcg cagagggaaa ccggatcagt tgagagagaa tcaagagtag cggatgaggc

181 gcttgtgggg cgcggcccgg aagccctcgg gcgcgggctg ggagaaggag tgggcggagg

241 cgccgcagga ggctcccggg gcctggtcgg gccggctggg ccccgggcgc agtggaagaa

301 agggacgggc ggtgcccggt tgggcgtcct ggccagctca ccttgccctg gcggctcgcc

361 ccgcccggca cttgggagga gcagggcagg gcccgcggcc tttgcattct gggaccgccc

421 ccttccattc ccgggccagc ggcgagcggc agcgacggct ggagccgcag ctacagcatg

481 agagccggtg ccgctcctcc acgcctgcgg acgcgtggcg agcggaggca gcgctgcctg

541 ttcgcgccat gggggcaccg tggggctcgc cgacggcggc ggcgggcggg cggcgcgggt

601 ggcgccgagg ccgggggctg ccatggaccg tctgtgtgct ggcggccgcc ggcttgacgt

661 gtacggcgct gatcacctac gcttgctggg ggcagctgcc gccgctgccc tgggcgtcgc

721 caaccccgtc gcgaccggtg ggcgtgctgc tgtggtggga gcccttcggg gggcgcgata

781 gcgccccgag gccgccccct gactgccggc tgcgcttcaa catcagcggc tgccgcctgc

841 tcaccgaccg cgcgtcctac ggagaggctc aggccgtgct tttccaccac cgcgacctcg gθl tgaaggggcc ccccgactgg cccccgccct ggggcatcca ggcgcacact gccgaggagg 61 tggatctgcg cgtgttggac tacgaggagg cagcggcggc ggcagaagcc ctggcgacct

1021 ccagccccag gcccccgggc cagcgctggg tttggatgaa cttcgagtcg ccctcgcact

1081 ccccggggct gcgaagcctg gcaagtaacc tcttcaactg gacgctctcc taccgggcgg

1141 actcggacgt ctttgtgcct tatggctacc tctaccccag aagccacccc ggcgacccgc

1201 cctcaggcct ggccccgcca ctgtccagga aacaggggct ggtggcatgg gtggtgagcc

1261 actgggacga gcgccaggcc cgggtccgct actaccacca actgagccaa catgtgaccg

1321 tggacgtgtt cggccggggc gggccggggc agccggtgcc cgaaattggg ctcctgcaca

1381 cagtggcccg ctacaagttc tacctggctt tcgagaactc gcagcacctg gattatatca

1441 ccgagaagct ctggcgcaac gcgttgctcg ctggggcggt gccggtggtg ctgggcccag

1501 accgtgccaa ctacgagcgc tttgtgcccc gcggcgcctt catccacgtg gacgacttcc

1561 caagtgcctc ctccctggcc tcgtacctgc ttttcctcga ccgcaacccc gcggtctatc

1621 gccgctactt ccactggcgc cggagctacg ctgtccacat cacctccttc tgggacgagc

1681 cttggtgccg ggtgtgccag gctgtacaga gggctgggga ccggcccaag agcatacgga

1741 acttggccag ctggttcgag cggtgaagcc gcgctcccct ggaagcgacc caggggaggc

1801 caagttgtca gctttttgat cctctactgt gcatctcctt gactgccgca tcatgggagt

1861 aagttcttca aacacccatt tttgctctat gggaaaaaaa cgatttacca attaatatta

1921 ctcagcacag agatgggggc ccggtttcca tattttttgc acagctagca attgggctcc

1981 ctttgctgct gatgggcatc attgtttagg ggtgaaggag ggggttcttc ctcaccttgt

2041 aaccagtgca gaaatgaaat agcttagcgg caagaagccg ttgaggcggt ttcctgaatt

2101 tccccatctg ccacaggcca tatttgtggc ccgtgcagct tccaaatctc atacacaact

2161 gttcccgatt cacgtttttc tggaccaagg tgaagcaaat ttgtggttgt agaaggagcc

2221 ttgttggtgg agagtggaag gactgtggct gcaggtggga ctttgttgtt tggattcctc

2281 acagccttgg ctcctgagaa aggtgaggag ggcagtccaa gaggggccgc tgacttcttt

2341 cacaagtact atctgttccc ctgtcctgtg aatggaagca aagtgctgga ttgtccttgg

2401 aggaaactta agatgaatac atgcgtgtac ctcactttac ataagaaatg tattcctgaa

2461 aagctgcatt taaatcaagt cccaaattca ttgacttagg ggagttcagt atttaatgaa

2521 accctatgga gaatttatcc ctttacaatg tgaatagtca tctcctaatt tgtttcttct

2581 gtctttatgt ttttctataa cctggatttt ttaaatcata ttaaaattac agatgtgaaa

2641 ataaagcaga agcaaccttt ttccctcttc ccagaaaacc agtctgtgtt tacagacaga

2701 agagaaggaa gccatagtgt cacttccaca caattattta tttcatgtct ttactggacc

2761 tgaaatttaa actgcaatgc cagtcctgca ggagtgctgg cattaccctc tgcagaacag

2821 tgaaaggtat tgcactacat tatggaatca tgcaaaaaaa a

(2) INFORMATION FOR SEQ ID NO:2701: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear EPI-109 957

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2701

1 acgcgtggcg agcggaggca gcgctgcctg ttcgcgccat gggggcaccg tggggctcgc

61 cgacggcggc ggcgggcggg cggcgcgggt ggcgccgagg ccgggggctg ccatggaccg

121 tctgtgtgct ggcggccgcc ggcttgacgt gtacggcgct gatcacctac gcttgctggg

181 ggcagctgcc gccgctgccc tgggcgtcgc caaccccgtc gcgaccggtg ggcgtgctgc

241 tgtggtggga gcccttcggg gggcgcgata gcgccccgag gccgccccct gactgcccgc

301 tgcgcttcaa catcagcggc tgccgcctgc tcaccgaccg cgcgtcctac ggagaggctc

361 aggccgtgct tttccaccac cgcgacctcg tgaaggggcc ccccgactgg cccccgccct

421 ggggcatcca ggcgcacact gccgaggagg tggatctgcg cgtgttggac tacgaggagg

481 cagcggcggc ggcagaagcc ctggcgacct ccagccccag gcccccgggc cagcgctggg

541 tttggatgaa cttcgagtcg ccctcgcact ccccggggct gcgaagcctg gcaagtaacc

601 tcttcaactg gacgctctcc taccgggcgg actcggacgt ctttgtgcct tatggctacc

661 tctaccccag aagccacccc ggcgacccgc cctcaggcct ggccccgcca ctgtccagga

721 aacaggggct ggtggcatgg gtggtgagcc actgggacga gcgccaggcc cgggtccgct

781 actaccacca actgagccaa catgtgaccg tggacgtgtt cggccggggc gggccggggc

841 agccggtgcc cgaaattggg ctcctgcaca cagtggcccg ctacaagttc tacctggctt

901 tcgagaactc gcagcacctg gattatatca ccgagaagct ctggcgcaac gcgttgctcg

961 ctggggcggt gccggtggtg ctgggcccag accgtgccaa ctacgagcgc tttgtgcccc

1021 gcggcgcctt catccacgtg gacgacttcc caagtgcctc ctccctggcc tcgtacctgc

1081 ttttcctcga ccgcaacccc gcggtctatc gccgctactt ccactggcgc cggagctacg

1141 ctgtccacat cacctccttc tgggacgagc cttggtgccg ggtgtgccag gctgtacaga

1201 gggctgggga ccggcccaag agcatacgga acttggccag ctggttcgag cggtag

(2) INFORMATION FOR SEQ ID NO:2702: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2702

1 cagatactct gacccatgga tcccctgggc ccggccaagc cacagtggtc gtggcgctgc

61 tgtctgacca cgctgctgtt tcagctgctg atggctgtgt gtttcttctc ctatctgcgt

121 gtgtctcaag acgatcccac tgtgtaccct aatgggtccc gcttcccaga cagcacaggg

181 acccccgccc actccatccc cctgatcctg ctgtggacgt ggccttttaa caaacccata

241 gctctgcccc gctgctcaga gatggtgcct ggcacggctg actgcaacat cactgccgac

301 cgcaaggtgt atccacaggc agacgcggtc atcgtgcacc accgagaggt catgtacaac

361 cccagtgccc agctcccacg ctccccgagg cggcaggggc agcgatggat ctggttcagc

421 atggagtccc caagccactg ctggcagctg aaagccatgg acggatactt caatctcacc

481 atgtcctacc gcagcgactc cgacatcttc acgccctacg gctggctgga gccgtggtcc

541 ggccagcctg cccacccacc gctcaacctc tcggccaaga ccgagctggt ggcctgggca

601 gtgtccaact gggggccaaa ctccgccagg gtgcgctact accagagcct gcaggcccat

661 ctcaaggtgg acgtgtacgg acgctcccac aagcccctgc cccagggaac catgatggag

721 acgctgtccc ggtacaagtt ctatctggcc ttcgagaact ccttgcaccc cgactacatc

781 accgagaagc tgtggaggaa cgccctggag gcctgggccg tgcccgtggt gctgggcccc

841 agcagaagca actacgagag gttcctgccg cccgacgcct tcatccacgt ggacgacttc

901 cagagcccca aggacctggc ccggtacctg caggagctgg acaaggacca cgcccgctac

961 ctgagctact ttcgctggcg ggagacgctg cggcctcgct ccttcagctg ggcactcgct

1021 ttctgcaagg cctgctggaa actgcaggag gaatccaggt accagacacg cggcatagcg

1081 gcttggttca cctgagaggc ccggcatggg gcctgggctg ccaggg

(2) INFORMATION FOR SEQ ID NO: 2703: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2703

1 aaggagcaca gttccaggcg gggctgagct agggcgtagc tgtgatttca ggggcacctc

61 tggcggctgc cgtgatttga gaatctcggg tctcttggct gactgatcct gggagactgt

121 ggatgaataa tgctgggcac ggccccaccc ggaggctgcg aggcttgggg gtcctggccg

181 gggtggctct gctcgctgcc ctctggctcc tgtggctgct ggggtcagcc cctcggggta

241 ccccggcacc ccagcccacg atcaccatcc ttgtctggca ctggcccttc actgaccagc

301 ccccagagct gcccagcgac acctgcaccc gctacggcat cgcccgctgc cacctgagtg

361 ccaaccgaag cctgctggcc agcgccgacg ccgtggtctt ccaccaccgc gagctgcaga

421 cccggcggtc ccacctgccc ctggcccagc ggccgcgagg gcagccctgg gtgtgggcct

481 ccatggagtc tcctagccac acccacggcc tcagccacct ccgaggcatc ttcaactggg

541 tgctgagcta ccggcgcgac tcggacatct ttgtgcccta tggccgcctg gagccccact

601 gggggccctc gccaccgctg ccagccaaga gcagggtggc cgcctgggtg gtcagcaact

661 tccaggagcg gcagctgcgt gccaggctgt accggcagct ggcgcctcat ctgcgggtgg EPI-109 958

721 atgtctttgg ccgtgccaat ggacggccac tgtgcgccag ctgcctggtg cccaccgtgg

781 cccagtaccg cttctacctg tcctttgaga actctcagca ccgcgactac attacggaga

841 aattctggcg caacgcactg gtggctggca ctgtgccagt ggtgctgggg cccccacggg

901 ccacctatga ggccttcgtg ccggctgacg ccttcgtgca tgtggatgac tttggctcag

961 cccgagagct ggcggctttc ctcactggca tgaatgagag ccgataccaa cgcttctttg

1021 cctggcgtga caggctccgc gtgcgactgt tcaccgactg gcgggaacgt ttctgtgcca

1081 tctgtgaccg ctacccacac ctaccccgca gccaagtcta tgaggacctt gagggttggt

1141 ttcaggcctg agatccgctg gccgggggag gtgggtgtgg gtggaagggc tgggtgtcga

1201 aatcaaacca ccaggcatcc ggcccttacc ggcaagcagc gggctaacgg gaggctgggc

1261 acagaggtca ggaagcaggg gtggggggtg caggtgggca ctggagcatg cagaggaggt

1321 gagagtggga gggaggtaac gggtgcctgc tgcggcagac gggaggggaa aggctgccga

1381 ggaccctccc caccctgaac aaatcttggg tgggtgaagg cctggctgga agagggtgaa

1441 aggcagggcc cttggggctg gggggcaccc cagcctgaag tttgtggggg ccaaacctgg

1501 gaccccgagc ttcctcggta gcagaggccc tgtggtcccc gagacacagg cacgggtccc

1561 tgccacgtcc atagttctga ggtccctgtg tgtaggctgg ggcggggccc aggagaccac

1621 ggggagcaaa ccagcttgtt ctgggctcag ggagggaggg cggtggacaa taaacgtctg

1681 agcagtgaaa aaaaaaaaaa a

(2) INFORMATION FOR SEQ ID NO: 2704: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2704

1 ctgctcctgc gcggcagctg ctttagaagg tctcgagcct cctgtacctt cccagggatg

61 aaccgggcct tccctctgga aggcgagggt tcgggccaca gtgagcgagg gccagggcgg

121 tgggcgcgcg cagagggaaa ccggatcagt tgagagagaa tcaagagtag cggatgaggc

181 gcttgtgggg cgcggcccgg aagccctcgg gcgcgggctg ggagaaggag tgggcggagg

241 cgccgcagga ggctcccggg gcctggtcgg gccggctggg ccccgggcgc agtggaagaa

301 agggacgggc ggtgcccggt tgggcgtcct ggccagctca ccttgccctg gcggctcgcc

361 ccgcccggca cttgggagga gcagggcagg gcccgcggcc tttgcattct gggaccgccc

421 ccttccattc ccgggccagc ggcgagcggc agcgacggct ggagccgcag ctacagcatg

481 agagccggtg ccgctcctcc acgcctgcgg acgcgtggcg agcggaggca gcgctgcctg

541 ttcgcgccat gggggcaccg tggggctcgc cgacggcggc ggcgggcggg cggcgcgggt

601 ggcgccgagg ccgggggctg ccatggaccg tctgtgtgct ggcggccgcc ggcttgacgt

661 gtacggcgct gatcacctac gcttgctggg ggcagctgcc gccgctgccc tgggcgtcgc

721 caaccccgtc gcgaccggtg ggcgtgctgc tgtggtggga gcccttcggg gggcgcgata

781 gcgccccgag gccgccccct gactgccggc tgcgcttcaa catcagcggc tgccgcctgc

841 tcaccgaccg cgcgtcctac ggagaggctc aggccgtgct tttccaccac cgcgacctcg

901 tgaaggggcc ccccgactgg cccccgccct ggggcatcca ggcgcacact gccgaggagg

961 tggatctgcg cgtgttggac tacgaggagg cagcggcggc ggcagaagcc ctggcgacct

1021 ccagccccag gcccccgggc cagcgctggg tttggatgaa cttcgagtcg ccctcgcact

1081 ccccggggct gcgaagcctg gcaagtaacc tcttcaactg gacgctctcc taccgggcgg

1141 actcggacgt ctttgtgcct tatggctacc tctaccccag aagccacccc ggcgacccgc

1201 cctcaggcct ggccccgcca ctgtccagga aacaggggct ggtggcatgg gtggtgagcc

1261 actgggacga gcgccaggcc cgggtccgct actaccacca actgagccaa catgtgaccg

1321 tggacgtgtt cggccggggc gggccggggc agccggtgcc cgaaattggg ctcctgcaca

1381 cagtggcccg ctacaagttc tacctggctt tcgagaactc gcagcacctg gattatatca

1441 ccgagaagct ctggcgcaac gcgttgctcg ctggggcggt gccggtggtg ctgggcccag

1501 accgtgccaa ctacgagcgc tttgtgcccc gcggcgcctt catccacgtg gacgacttcc

1561 caagtgcctc ctccctggcc tcgtacctgc ttttcctcga ccgcaacccc gcggtctatc

1621 gccgctactt ccactggcgc cggagctacg ctgtccacat cacctccttc tgggacgagc

1681 cttggtgccg ggtgtgccag gctgtacaga gggctgggga ccggcccaag agcatacgga

1741 acttggccag ctggttcgag cggtgaagcc gcgctcccct ggaagcgacc caggggaggc 1801 caagttgtca gctttttgat cctctactgt gcatctcctt gactgccgca tcatgggagt

1861 aagttcttca aacacccatt tttgctctat gggaaaaaaa cgatttacca attaatatta 1921 ctcagcacag agatgggggc ccggtttcca tattttttgc acagctagca attgggctcc 1981 ctttgctgct gatgggcatc attgtttagg ggtgaaggag ggggttcttc ctcaccttgt 2041 aaccagtgca gaaatgaaat agcttagcgg caagaagccg ttgaggcggt ttcctgaatt 2101 tccccatctg ccacaggcca tatttgtggc ccgtgcagct tccaaatctc atacacaact 2161 gttcccgatt cacgtttttc tggaccaagg tgaagcaaat ttgtggttgt agaaggagcc 2221 ttgttggtgg agagtggaag gactgtggct gcaggtggga ctttgttgtt tggattcctc 2281 acagccttgg ctcctgagaa aggtgaggag ggcagtccaa gaggggccgc tgacttcttt 2341 cacaagtact atctgttccc ctgtcctgtg aatggaagca aagtgctgga ttgtccttgg 2401 aggaaactta agatgaatac atgcgtgtac ctcactttac ataagaaatg tattcctgaa 2461 aagctgcatt taaatcaagt cccaaattca ttgacttagg ggagttcagt atttaatgaa 2521 accctatgga gaatttatcc ctttacaatg tgaatagtca tctcctaatt tgtttcttct 2581 gtctttatgt ttttctataa cctggatttt ttaaatcata ttaaaattac agatgtgaaa EPI-109 959

2641 ataaagcaga agcaaccttt ttccctcttc ccagaaaacc agtctgtgtt tacagacaga

2701 agagaaggaa gccatagtgt cacttccaca caattattta tttcatgtct ttactggacc

2761 tgaaatttaa actgcaatgc cagtcctgca ggagtgctgg cattaccctc tgcagaacag 2821 tgaaaggtat tgcactacat tatggaatca tgcaaaaaaa a

1 acgcgtggcg agcggaggca gcgctgcctg ttcgcgccat gggggcaccg tggggctcgc

61 cgacggcggc ggcgggcggg cggcgcgggt ggcgccgagg ccgggggctg ccatggaccg

121 tctgtgtgct ggcggccgcc ggcttgacgt gtacggcgct gatcacctac gcttgctggg

181 ggcagctgcc gccgctgccc tgggcgtcgc caaccccgtc gcgaccggtg ggcgtgctgc

241 tgtggtggga gcccttcggg gggcgcgata gcgccccgag gccgccccct gactgcccgc

301 tgcgcttcaa catcagcggc tgccgcctgc tcaccgaccg cgcgtcctac ggagaggctc

361 aggccgtgct tttccaccac cgcgacctcg tgaaggggcc ccccgactgg cccccgccct

421 ggggcatcca ggcgcacact gccgaggagg tggatctgcg cgtgttggac tacgaggagg

481 cagcggcggc ggcagaagcc ctggcgacct ccagccccag gcccccgggc cagcgctggg

541 tttggatgaa cttcgagtcg ccctcgcact ccccggggct gcgaagcctg gcaagtaacc

601 tcttcaactg gacgctctcc taccgggcgg actcggacgt ctttgtgcct tatggctacc

661 tctaccccag aagccacccc ggcgacccgc cctcaggcct ggccccgcca ctgtccagga

721 aacaggggct ggtggcatgg gtggtgagcc actgggacga gcgccaggcc cgggtccgct

781 actaccacca actgagccaa catgtgaccg tggacgtgtt cggccggggc gggccggggc

841 agccggtgcc cgaaattggg ctcctgcaca cagtggcccg ctacaagttc tacctggctt

901 tcgagaactc gcagcacctg gattatatca ccgagaagct ctggcgcaac gcgttgctcg

961 ctggggcggt gccggtggtg ctgggcccag accgtgccaa ctacgagcgc tttgtgcccc

1021 gcggcgcctt catccacgtg gacgacttcc caagtgcctc ctccctggcc tcgtacctgc

1081 ttttcctcga ccgcaacccc gcggtctatc gccgctactt ccactggcgc cggagctacg

1141 ctgtccacat cacctccttc tgggacgagc cttggtgccg ggtgtgccag gctgtacaga

1201 gggctgggga ccggcccaag agcatacgga acttggccag ctggttcgag cggtag

1 cagatactct gacccatgga tcccctgggc ccggccaagc cacagtggtc gtggcgctgc

61 tgtctgacca cgctgctgtt tcagctgctg atggctgtgt gtttcttctc ctatctgcgt

121 gtgtctcaag acgatcccac tgtgtaccct aatgggtccc gcttcccaga cagcacaggg

181 acccccgccc actccatccc cctgatcctg ctgtggacgt ggccttttaa caaacccata

241 gctctgcccc gctgctcaga gatggtgcct ggcacggctg actgcaacat cactgccgac

301 cgcaaggtgt atccacaggc agacgcggtc atcgtgcacc accgagaggt catgtacaac

361 cccagtgccc agctcccacg ctccccgagg cggcaggggc agcgatggat ctggttcagc

421 atggagtccc caagccactg ctggcagctg aaagccatgg acggatactt caatctcacc

481 atgtcctacc gcagcgactc cgacatcttc acgccctacg gctggctgga gccgtggtcc

541 ggccagcctg cccacccacc gctcaacctc tcggccaaga ccgagctggt ggcctgggca

601 gtgtccaact gggggccaaa ctccgccagg gtgcgctact accagagcct gcaggcccat

661 ctcaaggtgg acgtgtacgg acgctcccac aagcccctgc cccagggaac catgatggag

721 acgctgtccc ggtacaagtt ctatctggcc ttcgagaact ccttgcaccc cgactacatc

781 accgagaagc tgtggaggaa cgccctggag gcctgggccg tgcccgtggt gctgggcccc

841 agcagaagca actacgagag gttcctgccg cccgacgcct tcatccacgt ggacgacttc

901 cagagcccca aggacctggc ccggtacctg caggagctgg acaaggacca cgcccgctac

961 ctgagctact ttcgctggcg ggagacgctg cggcctcgct ccttcagctg ggcactcgct

1021 ttctgcaagg cctgctggaa actgcaggag gaatccaggt accagacacg cggcatagcg 1081 gcttggttca cctgagaggc ccggcatggg gcctgggctg ccaggg

1 aaggagcaca gttccaggcg gggctgagct agggcgtagc tgtgatttca ggggcacctc

61 tggcggctgc cgtgatttga gaatctcggg tctcttggct gactgatcct gggagactgt

121 ggatgaataa tgctgggcac ggccccaccc ggaggctgcg aggcttgggg gtcctggccg

181 gggtggctct gctcgctgcc ctctggctcc tgtggctgct ggggtcagcc cctcggggta

241 ccccggcacc ccagcccacg atcaccatcc ttgtctggca ctggcccttc actgaccagc

301 ccccagagct gcccagcgac acctgcaccc gctacggcat cgcccgctgc cacctgagtg

361 ccaaccgaag cctgctggcc agcgccgacg ccgtggtctt ccaccaccgc gagctgcaga

421 cccggcggtc ccacctgccc ctggcccagc ggccgcgagg gcagccctgg gtgtgggcct

481 ccatggagtc tcctagccac acccacggcc tcagccacct ccgaggcatc ttcaactggg

541 tgctgagcta ccggcgcgac tcggacatct ttgtgcccta tggccgcctg gagccccact

601 gggggccctc gccaccgctg ccagccaaga gcagggtggc cgcctgggtg gtcagcaact

661 tccaggagcg gcagctgcgt gccaggctgt accggcagct ggcgcctcat ctgcgggtgg

721 atgtctttgg ccgtgccaat ggacggccac tgtgcgccag ctgcctggtg cccaccgtgg

781 cccagtaccg cttctacctg tcctttgaga actctcagca ccgcgactac attacggaga

841 aattctggcg caacgcactg gtggctggca ctgtgccagt ggtgctgggg cccccacggg

901 ccacctatga ggccttcgtg ccggctgacg ccttcgtgca tgtggatgac tttggctcag

961 cccgagagct ggcggctttc ctcactggca tgaatgagag ccgataccaa cgcttctttg

1021 cctggcgtga caggctccgc gtgcgactgt tcaccgactg gcgggaacgt ttctgtgcca

1081 tctgtgaccg ctacccacac ctaccccgca gccaagtcta tgaggacctt gagggttggt

1141 ttcaggcctg agatccgctg gccgggggag gtgggtgtgg gtggaagggc tgggtgtcga

1201 aatcaaacca ccaggcatcc ggcccttacc ggcaagcagc gggctaacgg gaggctgggc

1261 acagaggtca ggaagcaggg gtggggggtg caggtgggca ctggagcatg cagaggaggt

1321 gagagtggga gggaggtaac gggtgcctgc tgcggcagac gggaggggaa aggctgccga

1381 ggaccctccc caccctgaac aaatcttggg tgggtgaagg cctggctgga agagggtgaa EPI-109 960

1441 aggcagggcc cttggggctg gggggcaccc cagcctgaag tttgtggggg ccaaacctgg

1501 gaccccgagc ttcctcggta gcagaggccc tgtggtcccc gagacacagg cacgggtccc

1561 tgccacgtcc atagttctga ggtccctgtg tgtaggctgg ggcggggccc aggagaccac

1621 ggggagcaaa ccagcttgtt ctgggctcag ggagggaggg cggtggacaa taaacgtctg

1681 agcagtgaaa aaaaaaaaaa a

(2) INFORMATION FOR SEQ ID NO: 2705: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2705

1 cccccctcca agataatttt taaaaaacct tctcctttgc tcacctttgc ttcccagcct

61 tcccatcccc ccaccgaaag caaatcattc aacgaccccc gaccctccga cggcaggagc

121 cccccgacct cccaggcgga ccgccctccc tccccggggt tccgggcccg gcgagagggc

181 gcgagcacag ccgaggccat ggaggtgacg gcggaccagc cgcgctgggt gagccaccac

241 caccccgccg tgctcaacgg gcagcacccg gacacgcacc acccgggcct cagccactcc

301 tacatggacg cggcgcagta cccgctgccg gaggaggtgg atgtgctttt taacatcgac

361 ggtcaaggca accacgtccc gccctactac ggaaactcgg tcagggccac ggtgcagagg

421 taccctccga cccaccacgg gagccaggtg tgccgcccgc ctctgcttca tggatcccta

481 ccctggctgg acggcggcaa agccctgggc agccaccaca ccgcctcccc ctggaatctc

541 agccccttct ccaagacgtc catccaccac ggctccccgg ggcccctctc cgtctacccc

601 ccggcctcgt cctcctcctt gtcggggggc cacgccagcc cgcacctctt caccttcccg

661 cccaccccgc cgaaggacgt ctccccggac ccatcgctgt ccaccccagg ctcggccggc

721 tcggcccggc aggacgagaa agagtgcctc aagtaccagg tgcccctgcc cgacagcatg

781 aagctggagt cgtcccactc ccgtggcagc atgaccgccc tgggtggagc ctcctcgtcg

841 acccaccacc ccatcaccac ctacccgccc tacgtgcccg agtacagctc cggactcttc

901 ccccccagca gcctgctggg cggctccccc accggcttcg gatgcaagtc caggcccaag

961 gcccggtcca gcacagaagg cagggagtgt gtgaactgtg gggcaacctc gaccccactg

1021 tggcggcgag atggcacggg acactacctg tgcaacgcct gcgggctcta tcacaaaatg

1081 aacggacaga accggcccct cattaagccc aagcgaaggc tgtctgcagc caggagagca

1141 gggacgtcct gtgcgaactg tcagaccacc acaaccacac tctggaggag gaatgccaat

1201 ggggaccctg tctgcaatgc ctgtgggctc tactacaagc ttcacaatat taacagaccc

1261 ctgactatga agaaggaagg catccagacc agaaaccgaa aaatgtctag caaatccaaa

1321 aagtgcaaaa aagtgcatga ctcactggag gacttcccca agaacagctc gtttaacccg

1381 gccgccctct ccagacacat gtcctccctg agccacatct cgcccttcag ccactccagc

1441 cacatgctga ccacgcccac gccgatgcac ccgccatcca gcctgtcctt tggaccacac

1501 cacccctcca gcatggtcac cgccatgggt tagagccctg ctcgatgctc acagggcccc

1561 cagcgagagt ccctgcagtc cctttcgact tgcatttttg caggagcagt atcatgaagc

1621 ctaaacgcga tggatatatg tttttgaagg cagaaagcaa aattatgttt gccactttgc

1681 aaaggagctc actgtggtgt ctgtgttcca accactgaat ctggacccca tctgtgaata

1741 agccattctg actcatatcc cctatttaac agggtctcta gtgctgtgaa aaaaaaaatg

1801 ctgaacattg catataactt atattgtaag aaatactgta caatgacttt attgcatctg

1861 ggtagctgta aggcatgaag gatgccaaga agtttaagga atatgggaga aatggtgtgg

1921 aaattaagaa gaaactaggt ctgatattca aatggacaaa ctgccagttt tgtttccttt

1981 cactggccac agttgtttga tgcattaaaa gaaaataaaa aaaag

(2) INFORMATION FOR SEQ ID NO:2706: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2706

1 acacagagag aaaggctaaa gttctctgga ggatgtggct gcagagcctg ctgctcttgg

61 gcactgtggc ctgcagcatc tctgcacccg cccgctcgcc cagccccagc acgcagccct

121 gggagcatgt gaatgccatc caggaggccc ggcgtctcct gaacctgagt agagacactg

181 ctgctgagat gaatgaaaca gtagaagtca tctcagaaat gtttgacctc caggagccga

241 cctgcctaca gacccgcctg gagctgtaca agcagggcct gcggggcagc ctcaccaagc

301 tcaagggccc cttgaccatg atggccagcc actacaagca gcactgccct ccaaccccgg

361 aaacttcctg tgcaacccag attatcacct ttgaaagttt caaagagaac ctgaaggact

421 ttctgcttgt catccccttt gactgctggg agccagtcca ggagtgagac cggccagatg

481 aggctggcca agccggggag ctgctctctc atgaaacaag agctagaaac tcaggatggt

541 catcttggag ggaccaaggg gtgggccaca gccatggtgg gagtggcctg gacctgccct

601 gggcacactg accctgatac aggcatggca gaagaatggg aatattttat actgacagaa

661 atcagtaata tttatatatt tatattttta aaatatttat ttatttattt atttaagttc

721 atattccata tttattcaag atgttttacc gtaataatta ttattaaaaa tagcttctaa

781 aaaaaaaaa EPI-109 961

(2) INFORMATION FOR SEQ ID NO: 2707: (i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2707

1 ttctctctga ccagcaccat gcttctcctg gtgacaagcc ttctgctctg tgagttacca

61 cacccagcat tcctcctgat cccagagaaa tcggatctgc gaacagtggc accagcctct

121 agtctcaatg tgaggtttga ctccaggacg atgaatttaa gctgggactg ccaagaaaac

181 acaaccttca gcaagtgttt cttaactgac aagaagaaca gagtcgtgga acccaggctc

241 agtaacaacg aatgttcgtg cacatttcgt gaaatttgtc tgcatgaagg agtcacattt

301 gaggttcacg tgaatactag tcaaagagga tttcaacaga aactgcttta tccaaattca

361 ggaagggagg gtaccgctgc tcagaatttc tcctgtttca tctacaatgc ggatttaatg

421 aactgtacct gggcgagggg tccgacggcc ccccgtgacg tccagtattt tttgtacata

481 cgaaactcaa agagaaggag ggagatccgg tgtccttatt acatacaaga ctcaggaacc

541 catgtgggat gtcacctgga taacctgtca ggattaacgt ctcgcaatta ctttctggtt

601 aacggaacca gccgagaaat tggcatccaa ttctttgatt cacttttgga cacaaagaaa

661 atagaacgat tcaaccctcc cagcaatgtc accgtacgtt gcaacacgac gcactgcctc

721 gtacggtgga aacagcccag gacctatcag aagctgtcgt acctggactt tcagtaccag

781 ctggacgtcc acagaaagaa tacccagcct ggcacggaaa acctactgat taatgtttct

841 ggtgatttgg aaaatagata caactttcca agctctgagc ccagagcaaa acacagtgtg

901 aagatcagag ctgcagacgt ccgcatcttg aattggagct cctggagtga agccattgaa

961 tttggttcct taggatacag cggctgttcc cgccagttcc acagatcaaa gacaaactga

1021 atgataacca tgaggtggaa gacgagatca tctgggagga attcacccca gaggaaggga

1081 aaggctaccg cgaagaggtc ttgaccgtga aggaaattac ctgagaccca gagggtgtag

1141 gaatggcatg gacatctccg cctccgcgac acgggggaac tgttttcttg atgatgctgt

1201 gaacctttat atcattttct atgtttttat ttaaaaacat gacatttggg gccaggcgcg

1261 gtggctcacg cctgtaatcc cag

(2) INFORMATION FOR SEQ ID NO: 2708 (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2708

1 ttctcagagt ggctgcagtc tcgctgctgg atgtgcacat ggtggtcatt ccctctgctc

61 acaggggcag gggtcccccc ttactggact gaggttgccc cctgctccag gtcctgggtg

121 ggagcccatg tgaactgtca gtggggcagg tctgtgagag ctcccctcac actcaagtct

181 ctctcacagt ggccagagaa gaggaaggct ggagtcagaa tgaggcacca gggcgggcat

241 agcctgccca aaggcccctg ggattacagg caggatgggg agccctatct aagtgtctcc

301 cacgccccac cccagccatt ccaggccagg aagtccaaac tgtgcccctc agagggaggg

361 ggcagcctca ggcccattca gactgcccag ggagggctgg agagccctca ggaaggcggg

421 tgggtgggct gtcggttctt ggaaaggttc attaatgaaa acccccaagc ctgaccacct

481 agggaaaagg ctcaccgttc ccatgtgtgg ctgataaggg ccaggagatt ccacagttca

541 ggtagttccc ccgcctccct ggcattttgt ggtcaccatt aatcatttcc tctgtgtatt

601 taagagctct tttgccagtg agcccagcta cacagagaga aaggctaaag ttctctggag

661 gatgtggctg cagagcctgc tgctcttggg cactgtggcc tgcagcatct ctgcacccgc

721 ccgctcgccc agccccagca cgcagccctg ggagcatgtg aatgccatcc aggaggcccg

781 gcgtctcctg aacctgagta gagacactgc tgctgagatg gtaagtgaga gaatgtgggc

841 ctgtgctagg caccagtggc cctgactggc cacgcctgtc agcttgataa catgacattt

901 tccttttcta cagaatgaaa cagtagaagt catctcagaa atgtttgacc tccaggtaag

961 atgcttctct ctgacatagc tttccagaag cccctgccct ggggtggagg tggggactcc

1021 attttagatg gcaccacaca gggttgtcca ctttctctcc agtcagctgg ctgcaggagg

1081 agggggtagc aactgggtgc tcaagaggct gctggccgtg cccctatggc agtcacatga

1141 gctcctttat cagctgagcg gccatgggca gacctagcat tcaatggcca ggagtcacca

1201 ggggacaggt ggtaaagtgg gggtcacttc atgagacagg agctgtgggt ttggggcgct

1261 cactgtgccc cgagaccaag tcctgttgag acagtgctga ctacagagag gcacagaggg

1321 gtttcaggaa caacccttgc ccacccagca ggtccaggtg aggccccacc cccctctccc

1381 tgaatgatgg ggtgagagtc acctccttcc ctaaggctgg gctcctctcc aggtgccgct

1441 gagggtggcc tgggcggggc agtgagaagg gcaggttcgt gcctgccatg gacagggcag

1501 ggtctatgac tggacccagc ctgtgcccct cccaagccct actcctgggg gctgggggca

1561 gcagcaaaaa ggagtggtgg agagttcttg taccactgtg ggcacttggc cactgctcac

1621 cgacgaacga cattttccac aggagccgac ctgcctacag acccgcctgg agctgtacaa

1681 gcagggcctg cggggcagcc tcaccaagct caagggcccc ttgaccatga tggccagcca

1741 ctacaagcag cactgccctc caaccccggt gagtgcctac ggcagggcct ccagcaggaa

1801 tgtcttaatc tagggggtgg ggtcgacatg gggagagatc tatggctgtg gctgttcagg EPI-109 962

1861 accccagggg gtttctgtgc caacagttat gtaatgatta gccctccaga gaggaggcag

1921 acagcccatt tcatcccaag gagtcagagc cacagagcgc tgaagcccac agtgctcccc

1981 agcaggagct gctcctatcc tggtcattat tgtcattacg gttaatgagg tcagaggtga

2041 gggcaaaccc aaggaaactt ggggcctgcc caaggcccag aggaagtgcc caggcccaag

2101 tgccaccttc tggcaggact ttcctctggc cccacatggg gtgcttgaat tgcagaggat

2161 caaggaaggg aggctacttg gaatggacaa ggacctcagg cactccttcc tgcgggaagg

2221 gagcaaagtt tgtggccttg actccactcc ttctgggtgc ccagagacga cctcagccca

2281 gctgccctgc tctgccctgg gaccaaaaag gcaggcgttt gactgcccag aaggccaacc

2341 tcaggctggc acttaagtca ggcccttgac tctggctgcc actggcagag ctatgcactc

2401 cttggggaac acgtgggtgg cagcagcgtc acctgaccca ggtcagtggg tgtgtcctgg

2461 agtgggcctc ctggcctctg agttctaaga ggcagtagag aaacatgctg gtgcttcctt

2521 cccccacgtt acccacttgc ctggactcaa gtgtttttta tttttctttt tttaaaggaa

2581 acttcctgtg caacccagat tatcaccttt gaaagtttca aagagaacct gaaggacttt

2641 ctgcttgtca tcccctttga ctgctgggag ccagtccagg agtgagaccg gccagatgag

2701 gctggccaag ccggggagct gctctctcat gaaacaagag ctagaaactc aggatggtca

2761 tcttggaggg accaaggggt gggccacagc catggtggga gtggcctgga cctgccctgg

2821 gcacactgac cctgatacag gcatggcaga agaatgggaa tattttatac tgacagaaat

2881 cagtaatatt tatatattta tatttttaaa atatttattt atttatttat ttaagttcat

2941 attccatatt tattcaagat gttttaccgt aataattatt attaaaaata tgcttctact 3001 tgtccagtgt tctagtttgt ttttaaccat gagcaaatgc cat

(2) INFORMATION FOR SEQ ID NO:2709: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:270g

1 acacagagag aaaggctaaa gttctctgga ggatgtggct gcagagcctg ctgctcttgg

61 gcactgtggc ctgcagcatc tctgcacccg cccgctcgcc cagccccagc acgcagccct

121 gggagcatgt gaatgccatc caggaggccc ggcgtctcct gaacctgagt agagacactg

181 ctgctgagat gaatgaaaca gtagaagtca tctcagaaat gtttgacctc caggagccga

241 cctgcctaca gacccgcctg gagctgtaca agcagggcct gcggggcagc ctcaccaagc

301 tcaagggccc cttgaccatg atggccagcc actacaagca gcactgccct ccaaccccgg

361 aaacttcctg tgcaacccag attatcacct ttgaaagttt caaagagaac ctgaaggact

421 ttctgcttgt catccccttt gactgctggg agccagtcca ggagtgagac cggccagatg

481 aggctggcca agccggggag ctgctctctc atgaaacaag agctagaaac tcaggatggt

541 catcttggag ggaccaaggg gtgggccaca gccatggtgg gagtggcctg gacctgccct

601 gggcacactg accctgatac aggcatggca gaagaatggg aatattttat actgacagaa

661 atcagtaata tttatatatt tatattttta aaatatttat ttatttattt atttaagttc

721 atattccata tttattcaag atgttttacc gtaataatta ttattaaaaa tagcttctaa 781 aaaaaaaaa

1 ttctctctga ccagcaccat gcttctcctg gtgacaagcc ttctgctctg tgagttacca

61 cacccagcat tcctcctgat cccagagaaa tcggatctgc gaacagtggc accagcctct

121 agtctcaatg tgaggtttga ctccaggacg atgaatttaa gctgggactg ccaagaaaac

181 acaaccttca gcaagtgttt cttaactgac aagaagaaca gagtcgtgga acccaggctc

241 agtaacaacg aatgttcgtg cacatttcgt gaaatttgtc tgcatgaagg agtcacattt

301 gaggttcacg tgaatactag tcaaagagga tttcaacaga aactgcttta tccaaattca

361 ggaagggagg gtaccgctgc tcagaatttc tcctgtttca tctacaatgc ggatttaatg

421 aactgtacct gggcgagggg tccgacggcc ccccgtgacg tccagtattt tttgtacata

481 cgaaactcaa agagaaggag ggagatccgg tgtccttatt acatacaaga ctcaggaacc

541 catgtgggat gtcacctgga taacctgtca ggattaacgt ctcgcaatta ctttctggtt

601 aacggaacca gccgagaaat tggcatccaa ttctttgatt cacttttgga cacaaagaaa

661 atagaacgat tcaaccctcc cagcaatgtc accgtacgtt gcaacacgac gcactgcctc

721 gtacggtgga aacagcccag gacctatcag aagctgtcgt acctggactt tcagtaccag

781 ctggacgtcc acagaaagaa tacccagcct ggcacggaaa acctactgat taatgtttct

841 ggtgatttgg aaaatagata caactttcca agctctgagc ccagagcaaa acacagtgtg

901 aagatcagag ctgcagacgt ccgcatcttg aattggagct cctggagtga agccattgaa

961 tttggttcct taggatacag cggctgttcc cgccagttcc acagatcaaa gacaaactga

1021 atgataacca tgaggtggaa gacgagatca tctgggagga attcacccca gaggaaggga

1081 aaggctaccg cgaagaggtc ttgaccgtga aggaaattac ctgagaccca gagggtgtag

1141 gaatggcatg gacatctccg cctccgcgac acgggggaac tgttttcttg atgatgctgt

1201 gaacctttat atcattttct atgtttttat ttaaaaacat gacatttggg gccaggcgcg

1261 gtggctcacg cctgtaatcc cag

1 ttctcagagt ggctgcagtc tcgctgctgg atgtgcacat ggtggtcatt ccctctgctc

61 acaggggcag gggtcccccc ttactggact gaggttgccc cctgctccag gtcctgggtg

121 ggagcccatg tgaactgtca gtggggcagg tctgtgagag ctcccctcac actcaagtct

181 ctctcacagt ggccagagaa gaggaaggct ggagtcagaa tgaggcacca gggcgggcat

241 agcctgccca aaggcccctg ggattacagg caggatgggg agccctatct aagtgtctcc EPI-109 963

301 cacgccccac cccagccatt ccaggccagg aagtccaaac tgtgcccctc agagggaggg

361 ggcagcctca ggcccattca gactgcccag ggagggctgg agagccctca ggaaggcggg

421 tgggtgggct gtcggttctt ggaaaggttc attaatgaaa acccccaagc ctgaccacct

481 agggaaaagg ctcaccgttc ccatgtgtgg ctgataaggg ccaggagatt ccacagttca

541 ggtagttccc ccgcctccct ggcattttgt ggtcaccatt aatcatttcc tctgtgtatt

601 taagagctct tttgccagtg agcccagcta cacagagaga aaggctaaag ttctctggag

661 gatgtggctg cagagcctgc tgctcttggg cactgtggcc tgcagcatct ctgcacccgc

721 ccgctcgccc agccccagca cgcagccctg ggagcatgtg aatgccatcc aggaggcccg

781 gcgtctcctg aacctgagta gagacactgc tgctgagatg gtaagtgaga gaatgtgggc

841 ctgtgctagg caccagtggc cctgactggc cacgcctgtc agcttgataa catgacattt

901 tccttttcta cagaatgaaa cagtagaagt catctcagaa atgtttgacc tccaggtaag

961 atgcttctct ctgacatagc tttccagaag cccctgccct ggggtggagg tggggactcc

1021 attttagatg gcaccacaca gggttgtcca ctttctctcc agtcagctgg ctgcaggagg

1081 agggggtagc aactgggtgc tcaagaggct gctggccgtg cccctatggc agtcacatga

1141 gctcctttat cagctgagcg gccatgggca gacctagcat tcaatggcca ggagtcacca

1201 ggggacaggt ggtaaagtgg gggtcacttc atgagacagg agctgtgggt ttggggcgct

1261 cactgtgccc cgagaccaag tcctgttgag acagtgctga ctacagagag gcacagaggg

1321 gtttcaggaa caacccttgc ccacccagca ggtccaggtg aggccccacc cccctctccc

1381 tgaatgatgg ggtgagagtc acctccttcc ctaaggctgg gctcctctcc aggtgccgct

1441 gagggtggcc tgggcggggc agtgagaagg gcaggttcgt gcctgccatg gacagggcag

1501 ggtctatgac tggacccagc ctgtgcccct cccaagccct actcctgggg gctgggggca

1561 gcagcaaaaa ggagtggtgg agagttcttg taccactgtg ggcacttggc cactgctcac

1621 cgacgaacga cattttccac aggagccgac ctgcctacag acccgcctgg agctgtacaa

1681 gcagggcctg cggggcagcc tcaccaagct caagggcccc ttgaccatga tggccagcca

1741 ctacaagcag cactgccctc caaccccggt gagtgcctac ggcagggcct ccagcaggaa 1801 tgtcttaatc tagggggtgg ggtcgacatg gggagagatc tatggctgtg gctgttcagg

1861 accccagggg gtttctgtgc caacagttat gtaatgatta gccctccaga gaggaggcag 1921 acagcccatt tcatcccaag gagtcagagc cacagagcgc tgaagcccac agtgctcccc 1981 agcaggagct gctcctatcc tggtcattat tgtcattacg gttaatgagg tcagaggtga 2041 gggcaaaccc aaggaaactt ggggcctgcc caaggcccag aggaagtgcc caggcccaag 2101 tgccaccttc tggcaggact ttcctctggc cccacatggg gtgcttgaat tgcagaggat 2161 caaggaaggg aggctacttg gaatggacaa ggacctcagg cactccttcc tgcgggaagg 2221 gagcaaagtt tgtggccttg actccactcc ttctgggtgc ccagagacga cctcagccca 2281 gctgccctgc tctgccctgg gaccaaaaag gcaggcgttt gactgcccag aaggccaacc 2341 tcaggctggc acttaagtca ggcccttgac tctggctgcc actggcagag ctatgcactc 2401 cttggggaac acgtgggtgg cagcagcgtc acctgaccca ggtcagtggg tgtgtcctgg 2461 agtgggcctc ctggcctctg agttctaaga ggcagtagag aaacatgctg gtgcttcctt 2521 cccccacgtt acccacttgc ctggactcaa gtgtttttta tttttctttt tttaaaggaa 2581 acttcctgtg caacccagat tatcaccttt gaaagtttca aagagaacct gaaggacttt 2641 ctgcttgtca tcccctttga ctgctgggag ccagtccagg agtgagaccg gccagatgag 2701 gctggccaag ccggggagct gctctctcat gaaacaagag ctagaaactc aggatggtca 2761 tcttggaggg accaaggggt gggccacagc catggtggga gtggcctgga cctgccctgg 2821 gcacactgac cctgatacag gcatggcaga agaatgggaa tattttatac tgacagaaat 2881 cagtaatatt tatatattta tatttttaaa atatttattt atttatttat ttaagttcat 2941 attccatatt tattcaagat gttttaccgt aataattatt attaaaaata tgcttctact 3001 tgtccagtgt tctagtttgt ttttaaccat gagcaaatgc cat

(2) INFORMATION FOR SEQ ID NO:2710: (i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2710

1 atcctggctg atatggtgaa accccatctc tactaaaaat acaaaaatta gctgggcgtg

61 gtggtgggcg catgtaatcc cagctactca ggaggctgag gcaggagaat tacttgaacc

121 tgggaggcag aggttgcagt gaaccgagat cgcgccattg cactccagtc tggcgacaga

181 gcgagactcc gtctctaaat aaataaataa ataaatttag ccttctactc aagaacttat

241 ctggctttgt cttaatgtaa aaataatttc tttttgctaa attattgaga gaaatttact

301 atttattagt gtttatcagt tttctttaaa ctcaccactt tttgatgaat atgaaaatct

361 aaaaacttgg ccgggcgcag tggctcacac ctgtaatctc agcactttgg gaggccaagg

421 tgggcggatc atctgaggtc aggagttcaa gatcagcctg accaacatgg tgaaacccct

481 tctctactaa aaatacaaaa attagctggg cgtggtggtg ggtgcctgta attgtagcta

541 cttgggaggc tgaggcatga gaatcacttg aacccagaaa gcagaggttg cagtgagctg

601 agatggtgcc actgcactcc agcctgggtg acagagtgag actctgtcct aaaaaaaaaa

661 aaaaaaaaaa tggctgggcg tggtgcctca tgcctgtaat cccagcactt tgggagtcca

721 gcgtgggtgg atcacctgag gtcaggagtt caagtccagc ctgaccaaca tggtgaaacc

781 ccgtctctac taaaaaagta caaaaaaaat agccgggtgt ggtggcacac tcctgtaatc

841 ccagctactc aggaggctga ggcaggagaa tcacttgaat ttgggagctg gagattgtag EPI-109 964

901 tcagccaaga tggtgccatt gcactccagt ctgggtgaca gagtgagact ccatctcaaa

961 aaaaaaaaaa aaatcttaaa aactccttcc agaagattta atacttactt tcacccaacc

1021 acccgacttg agtatcacca ataacagagg atacagtccg ttttcagtag agccttagta

1081 gcaaagggtt ttcattttta tttttcagat acaggatctt gccctgtcac ccaagctgga

1141 gtgcagtgat gtgatcatag ctgactgcag cctcctgagt agctaggact ataggtgtat

1201 tataggacaa tttttaaaaa atttcattgt aaagacagga ttccactgtg ttgcccaggc

1261 tgcaagtctt ggcctcaagt gatcattcca cctttaactc ttgccctcaa gcagtcctcc

1321 cacctcagac tcccaaaatg ctgggattat gggtgtgagc caccatttcc agcctactag

1381 caagggtctt gttacatatt acttggcatg atttatgtaa tttaaaaaaa ttgtttgttt

1441 ttcaaataga aaagtaaaat aacgaatatg cttttccaat aacataatcc ccttctcact

1501 tgagaatttt cctctaaaaa gatatgctag atttatttca tgctttatgt gcctctggtg

1561 tgtcccctta taacctcctc catatcattt agggatggtc tcagctgcaa gtaagaactg

1621 ccacaacagg tgatgtaagc ccaaaaaaaa aaaaaaaaaa aaagcaaagc caagcaaaac

1681 aaagcccatt taattatttc ccataataat aagtctggga gaaagaagat tccagagttg

1741 gctcagcagc ttagtgacag caaggcccta ggctggcatt ttcttggcct tcccgatggt

1801 cccaagatga ctctcatggc ctcaaacatc acttcctcac atcctgtcag ggagaaagag

1861 gcaagtgagc aacaacaatt tgtggtgttt ggatcatttg tcagagagga agaacgttcc

1921 taaaaactcc gcctctgctg tttgacatcc tcatcctatt ccttggccat ggtggtatct

1981 catggtcact cctctatctg ccactgtaaa gaggaactgg attgctatat tctgcttaga

2041 cacatgagga tgcagcccac cttcccagaa catgtgcgga attagatttc tacaaacaca

2101 tttgtcttgc ttctgcccaa ctctctcact agaatgcaca ttccataggg gcaaacattt

2161 ttgtctattt tgttcacagc tatattctca acacctagaa gagtgacaga aattcaataa

2221 atagttgtta agtgagcaaa tgaatgcatg aataaggaaa agggtacatg gctattgagt

2281 aggtaaccag cagtgttgat cacccccaac agcatacaac tccagtctga tgaacatcat

2341 gctactaagt ggccactcat cacccaagtc tctgacctta ctttttctct cttttctccc

2401 agggagtgag ccataactgg cggctgctct tgcgccaatg

(2) INFORMATION FOR SEQ ID NO: 2711: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2711

1 ccaatgagcc tccccaattc ctcctgcctc ttagaagaca agatgtgtga gggcaacaag

61 accactatgg ccagccccca gctgatgccc ctggtggtgg tcctgagcac tatctgcttg

121 gtcacagtag ggctcaacct gctggtgctg tatgccgtac ggagtgagcg gaagctccac

181 actgtgggga acctgtacat cgtcagcctc tcggtggcgg acttgatcgt gggtgccgtc

241 gtcatgccta tgaacatcct ctacctgctc atgtccaagt ggtcactggg ccgtcctctc

301 tgcctctttt ggctttccat ggactatgtg gccagcacag cgtccatttt cagtgtcttc

361 atcctgtgca ttgatcgcta ccgctctgtc cagcagcccc tcaggtacct taagtatcgt

421 accaagaccc gagcctcggc caccattctg ggggcctggt ttctctcttt tctgtgggtt

481 attcccattc taggctggaa tcacttcatg cagcagacct cggtgcgccg agaggacaag

541 tgtgagacag acttctatga tgtcacctgg ttcaaggtca tgactgccat catcaacttc

601 tacctgccca ccttgctcat gctctggttc tatgccaaga tctacaaggc cgtacgacaa

661 cactgccagc accgggagct catcaatagg tccctccctt ccttctcaga aattaagctg

721 aggccagaga accccaaggg ggatgccaag aaaccaggga aggagtctcc ctgggaggtt

781 ctgaaaagga agccaaaaga tgctggtggt ggatctgtct tgaagtcacc atcccaaacc

841 cccaaggaga tgaaatcccc agttgtcttc agccaagagg atgatagaga agtagacaaa

901 ctctactgct ttccacttga tattgtgcac atgcaggctg cggcagaggg gagtagcagg

961 gactatgtag ccgtcaaccg gagccatggc cagctcaaga cagatgagca gggcctgaac

1021 acacatgggg ccagcgagat atcagaggat cagatgttag gtgatagcca atccttctct

1081 cgaacggact cagataccac cacagagaca gcaccaggca aaggcaaatt gaggagtggg

1141 tctaacacag gcctggatta catcaagttt acttggaaga ggctccgctc gcattcaaga

1201 cagtatgtat ctgggttgca catgaaccgc gaaaggaagg ccgccaaaca gttgggtttt

1261 atcatggcag ccttcatcct ctgctggatc ccttatttca tcttcttcat ggtcattgcc

1321 ttctgcaaga actgttgcaa tgaacatttg cacatgttca ccatctggct gggctacatc

1381 aactccacac tgaaccccct catctacccc ttgtgcaatg agaacttcaa gaagacattc

1441 aagagaattc tgcatattcg ctcctaaggg aggctctgag gggatgcaac aaaatgatcc

1501 ttatgatgtc caacaaggaa atagaggacg aaggcctgtg tgttgccagg caggcacctg

1561 ggctttctgg aatccaaacc acagtcttag gggcttggta gtttggaaag ttcttaggca

1621 ccatagaaga acagcagatg gcggtgatca gcag

(2) INFORMATION FOR SEQ ID NO: 2712: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear EPI-109 965

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2712

1 atgagcctcc ccaattcctc ctgcctctta gaagacaaga tgtgtgaggg caacaagacc

61 actatggcca gcccccagct gatgcccctg gtggtggtcc tgagcactat ctgcttggtc

121 acagtagggc tcaacctgct ggtgctgtat gccgtacgga gtgagcggaa gctccacact

181 gtggggaacc tgtacatcgt cagcctctcg gtggcggact tgatcgtggg tgccgtcgtc

241 atgcctatga acatcctcta cctgctcatg tccaagtggt cactgggccg tcctctctgc

301 ctcttttggc tttccatgga ctatgtggcc agcacagcgt ccattttcag tgtcttcatc

361 ctgtgcattg atcgctaccg ctctgtccag cagcccctca ggtaccttaa gtatcgtacc

421 aagacccgag cctcggccac cattctgggg gcctggtttc tctcttttct gtgggttatt

481 cccattctag gctggaatca cttcatgcag cagacctcgg tgcgccgaga ggacaagtgt

541 gagacagact tctatgatgt cacctggttc aaggtcatga ctgccatcat caacttctac

601 ctgcccacct tgctcatgct ctggttctat gccaagatct acaaggccgt acgacaacac

661 tgccagcacc gggagctcat caataggtcc ctcccttcct tctcagaaat taagctgagg

721 ccagagaacc ccaaggggga tgccaagaaa ccagggaagg agtctccctg ggaggttctg

781 aaaaggaagc caaaagatgc tggtggtgga tctgtcttga agtcaccatc ccaaaccccc

841 aaggagatga aatccccagt tgtcttcagc caagaggatg atagagaagt agacaaactc

901 tactgctttc cacttgatat tgtgcacatg caggctgcgg cagaggggag tagcagggac

961 tatgtagccg tcaaccggag ccatggccag ctcaagacag atgagcaggg cctgaacaca

1021 catggggcca gcgagatatc agaggatcag atgttaggtg atagccaatc cttctctcga

1081 acggactcag ataccaccac agagacagca ccaggcaaag gcaaattgag gagtgggtct

1141 aacacaggcc tggattacat caagtttact tggaagaggc tccgctcgca ttcaagacag

1201 tatgtatctg ggttgcacat gaaccgcgaa aggaaggccg ccaaacagtt gggttttatc

1261 atggcagcct tcatcctctg ctggatccct tatttcatct tcttcatggt cattgccttc

1321 tgcaagaact gttgcaatga acatttgcac atgttcacca tctggctggg ctacatcaac

1381 tccacactga accccctcat ctaccccttg tgcaatgaga acttcaagaa gacattcaag

1441 agaattctgc atattcgctc ctaagggagg ctctgagggg atgcaacaaa atgatcctta

1501 tgatgtccaa caaggaaata gaggacgaag gcctgtgtgt tgccaggcag gcacctgggc

1561 tttctggaat ccaaaccaca gtcttagggg cttggtagtt tggaaagttc ttaggcacca

1621 tagaagaaca gcagatggcg gtgatcagca gagagattga actttgagga ggaagcagaa

1681 tctttgcaag aaagtcagac ctgtttcttg taactgggtt caaaaagaaa aaaaaaaaaa

1741 aa

(2) INFORMATION FOR SEQ ID NO: 2713: (i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2713

1 atcctggctg atatggtgaa accccatctc tactaaaaat acaaaaatta gctgggcgtg

61 gtggtgggcg catgtaatcc cagctactca ggaggctgag gcaggagaat tacttgaacc

121 tgggaggcag aggttgcagt gaaccgagat cgcgccattg cactccagtc tggcgacaga

181 gcgagactcc gtctctaaat aaataaataa ataaatttag ccttctactc aagaacttat

241 ctggctttgt cttaatgtaa aaataatttc tttttgctaa attattgaga gaaatttact

301 atttattagt gtttatcagt tttctttaaa ctcaccactt tttgatgaat atgaaaatct

361 aaaaacttgg ccgggcgcag tggctcacac ctgtaatctc agcactttgg gaggccaagg

421 tgggcggatc atctgaggtc aggagttcaa gatcagcctg accaacatgg tgaaacccct

481 tctctactaa aaatacaaaa attagctggg cgtggtggtg ggtgcctgta attgtagcta

541 cttgggaggc tgaggcatga gaatcacttg aacccagaaa gcagaggttg cagtgagctg

601 agatggtgcc actgcactcc agcctgggtg acagagtgag actctgtcct aaaaaaaaaa

661 aaaaaaaaaa tggctgggcg tggtgcctca tgcctgtaat cccagcactt tgggagtcca

721 gcgtgggtgg atcacctgag gtcaggagtt caagtccagc ctgaccaaca tggtgaaacc

781 ccgtctctac taaaaaagta caaaaaaaat agccgggtgt ggtggcacac tcctgtaatc

841 ccagctactc aggaggctga ggcaggagaa tcacttgaat ttgggagctg gagattgtag

901 tcagccaaga tggtgccatt gcactccagt ctgggtgaca gagtgagact ccatctcaaa

961 aaaaaaaaaa aaatcttaaa aactccttcc agaagattta atacttactt tcacccaacc

1021 acccgacttg agtatcacca ataacagagg atacagtccg ttttcagtag agccttagta

1081 gcaaagggtt ttcattttta tttttcagat acaggatctt gccctgtcac ccaagctgga

1141 gtgcagtgat gtgatcatag ctgactgcag cctcctgagt agctaggact ataggtgtat

1201 tataggacaa tttttaaaaa atttcattgt aaagacagga ttccactgtg ttgcccaggc

1261 tgcaagtctt ggcctcaagt gatcattcca cctttaactc ttgccctcaa gcagtcctcc

1321 cacctcagac tcccaaaatg ctgggattat gggtgtgagc caccatttcc agcctactag

1381 caagggtctt gttacatatt acttggcatg atttatgtaa tttaaaaaaa ttgtttgttt

1441 ttcaaataga aaagtaaaat aacgaatatg cttttccaat aacataatcc ccttctcact

1501 tgagaatttt cctctaaaaa gatatgctag atttatttca tgctttatgt gcctctggtg

1561 tgtcccctta taacctcctc catatcattt agggatggtc tcagctgcaa gtaagaactg

1621 ccacaacagg tgatgtaagc ccaaaaaaaa aaaaaaaaaa aaagcaaagc caagcaaaac

1681 aaagcccatt taattatttc ccataataat aagtctggga gaaagaagat tccagagttg

1741 gctcagcagc ttagtgacag caaggcccta ggctggcatt ttcttggcct tcccgatggt EPI-109 966

1801 cccaagatga ctctcatggc ctcaaacatc acttcctcac atcctgtcag ggagaaagag

1861 gcaagtgagc aacaacaatt tgtggtgttt ggatcatttg tcagagagga agaacgttcc

1921 taaaaactcc gcctctgctg tttgacatcc tcatcctatt ccttggccat ggtggtatct

1981 catggtcact cctctatctg ccactgtaaa gaggaactgg attgctatat tctgcttaga

2041 cacatgagga tgcagcccac cttcccagaa catgtgcgga attagatttc tacaaacaca

2101 tttgtcttgc ttctgcccaa ctctctcact agaatgcaca ttccataggg gcaaacattt

2161 ttgtctattt tgttcacagc tatattctca acacctagaa gagtgacaga aattcaataa

2221 atagttgtta agtgagcaaa tgaatgcatg aataaggaaa agggtacatg gctattgagt

2281 aggtaaccag cagtgttgat cacccccaac agcatacaac tccagtctga tgaacatcat

2341 gctactaagt ggccactcat cacccaagtc tctgacctta ctttttctct cttttctccc

2401 agggagtgag ccataactgg cggctgctct tgcgccaatg

1 ccaatgagcc tccccaattc ctcctgcctc ttagaagaca agatgtgtga gggcaacaag

61 accactatgg ccagccccca gctgatgccc ctggtggtgg tcctgagcac tatctgcttg

121 gtcacagtag ggctcaacct gctggtgctg tatgccgtac ggagtgagcg gaagctccac

181 actgtgggga acctgtacat cgtcagcctc tcggtggcgg acttgatcgt gggtgccgtc

241 gtcatgccta tgaacatcct ctacctgctc atgtccaagt ggtcactggg ccgtcctctc

301 tgcctctttt ggctttccat ggactatgtg gccagcacag cgtccatttt cagtgtcttc

361 atcctgtgca ttgatcgcta ccgctctgtc cagcagcccc tcaggtacct taagtatcgt

421 accaagaccc gagcctcggc caccattctg ggggcctggt ttctctcttt tctgtgggtt

481 attcccattc taggctggaa tcacttcatg cagcagacct cggtgcgccg agaggacaag

541 tgtgagacag acttctatga tgtcacctgg ttcaaggtca tgactgccat catcaacttc

601 tacctgccca ccttgctcat gctctggttc tatgccaaga tctacaaggc cgtacgacaa

661 cactgccagc accgggagct catcaatagg tccctccctt ccttctcaga aattaagctg

721 aggccagaga accccaaggg ggatgccaag aaaccaggga aggagtctcc ctgggaggtt

781 ctgaaaagga agccaaaaga tgctggtggt ggatctgtct tgaagtcacc atcccaaacc

841 cccaaggaga tgaaatcccc agttgtcttc agccaagagg atgatagaga agtagacaaa

901 ctctactgct ttccacttga tattgtgcac atgcaggctg cggcagaggg gagtagcagg

961 gactatgtag ccgtcaaccg gagccatggc cagctcaaga cagatgagca gggcctgaac

1021 acacatgggg ccagcgagat atcagaggat cagatgttag gtgatagcca atccttctct

1081 cgaacggact cagataccac cacagagaca gcaccaggca aaggcaaatt gaggagtggg

1141 tctaacacag gcctggatta catcaagttt acttggaaga ggctccgctc gcattcaaga

1201 cagtatgtat ctgggttgca catgaaccgc gaaaggaagg ccgccaaaca gttgggtttt

1261 atcatggcag ccttcatcct ctgctggatc ccttatttca tcttcttcat ggtcattgcc

1321 ttctgcaaga actgttgcaa tgaacatttg cacatgttca ccatctggct gggctacatc

1381 aactccacac tgaaccccct catctacccc ttgtgcaatg agaacttcaa gaagacattc

1441 aagagaattc tgcatattcg ctcctaaggg aggctctgag gggatgcaac aaaatgatcc

1501 ttatgatgtc caacaaggaa atagaggacg aaggcctgtg tgttgccagg caggcacctg

1561 ggctttctgg aatccaaacc acagtcttag gggcttggta gtttggaaag ttcttaggca

1621 ccatagaaga acagcagatg gcggtgatca gcag

1 atgagcctcc ccaattcctc ctgcctctta gaagacaaga tgtgtgaggg caacaagacc

61 actatggcca gcccccagct gatgcccctg gtggtggtcc tgagcactat ctgcttggtc

121 acagtagggc tcaacctgct ggtgctgtat gccgtacgga gtgagcggaa gctccacact

181 gtggggaacc tgtacatcgt cagcctctcg gtggcggact tgatcgtggg tgccgtcgtc

241 atgcctatga acatcctcta cctgctcatg tccaagtggt cactgggccg tcctctctgc

301 ctcttttggc tttccatgga ctatgtggcc agcacagcgt ccattttcag tgtcttcatc

361 ctgtgcattg atcgctaccg ctctgtccag cagcccctca ggtaccttaa gtatcgtacc

421 aagacccgag cctcggccac cattctgggg gcctggtttc tctcttttct gtgggttatt

481 cccattctag gctggaatca cttcatgcag cagacctcgg tgcgccgaga ggacaagtgt

541 gagacagact tctatgatgt cacctggttc aaggtcatga ctgccatcat caacttctac

601 ctgcccacct tgctcatgct ctggttctat gccaagatct acaaggccgt acgacaacac

661 tgccagcacc gggagctcat caataggtcc ctcccttcct tctcagaaat taagctgagg

721 ccagagaacc ccaaggggga tgccaagaaa ccagggaagg agtctccctg ggaggttctg

781 aaaaggaagc caaaagatgc tggtggtgga tctgtcttga agtcaccatc ccaaaccccc

841 aaggagatga aatccccagt tgtcttcagc caagaggatg atagagaagt agacaaactc

901 tactgctttc cacttgatat tgtgcacatg caggctgcgg cagaggggag tagcagggac

961 tatgtagccg tcaaccggag ccatggccag ctcaagacag atgagcaggg cctgaacaca

1021 catggggcca gcgagatatc agaggatcag atgttaggtg atagccaatc cttctctcga

1081 acggactcag ataccaccac agagacagca ccaggcaaag gcaaattgag gagtgggtct

1141 aacacaggcc tggattacat caagtttact tggaagaggc tccgctcgca ttcaagacag

1201 tatgtatctg ggttgcacat gaaccgcgaa aggaaggccg ccaaacagtt gggttttatc

1261 atggcagcct tcatcctctg ctggatccct tatttcatct tcttcatggt cattgccttc

1321 tgcaagaact gttgcaatga acatttgcac atgttcacca tctggctggg ctacatcaac

1381 tccacactga accccctcat ctaccccttg tgcaatgaga acttcaagaa gacattcaag

1441 agaattctgc atattcgctc ctaagggagg ctctgagggg atgcaacaaa atgatcctta

1501 tgatgtccaa caaggaaata gaggacgaag gcctgtgtgt tgccaggcag gcacctgggc

1561 tttctggaat ccaaaccaca gtcttagggg cttggtagtt tggaaagttc ttaggcacca

1621 tagaagaaca gcagatggcg gtgatcagca gagagattga actttgagga ggaagcagaa

1681 tctttgcaag aaagtcagac ctgtttcttg taactgggtt caaaaagaaa aaaaaaaaaa EPI-109 967

1741 aa

(2) INFORMATION FOR SEQ ID NO:2714: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2714

1 cacgcgtccg cgagaaggag gactcgcaag cctcggcggc ccggaaccgg cctcggactg

61 tcgacggaac ctgaggccgc ttgccctccc gccccatgga gcggcccccg gggctgcggc

121 cgggcgcggg cgggccctgg gagatgcggg agcggctggg caccggcggc ttcgggaacg

181 tctgtctgta ccagcatcgg gaacttgatc tcaaaatagc aattaagtct tgtcgcctag

241 agctaagtac caaaaacaga gaacgatggt gccatgaaat ccagattatg aagaagttga

301 accatgccaa tgttgtaaag gcctgtgatg ttcctgaaga attgaatatt ttgattcatg

361 atgtgcctct tctagcaatg gaatactgtt ctggaggaga tctccgaaag ctgctcaaca

421 aaccagaaaa ttgttgtgga cttaaagaaa gccagatact ttctttacta agtgatatag

481 ggtctgggat tcgatatttg catgaaaaca aaattataca tcgagatcta aaacctgaaa

541 acatagttct tcaggatgtt ggtggaaaga taatacataa aataattgat ctgggatatg

601 ccaaagatgt tgatcaagga agtctgtgta catcttttgt gggaacactg cagtatctgg

661 ccccagagct ctttgagaat aagccttaca cagccactgt tgattattgg agctttggga

721 ccatggtatt tgaatgtatt gctggatata ggcctttttt gcatcatctg cagccattta

781 cctggcatga gaagattaag aagaaggatc caaagtgtat atttgcatgt gaagagatgt

841 caggagaagt tcggtttagt agccatttac ctcaaccaaa tagcctttgt agtttaatag

901 tagaacccat ggaaaactgg ctacagttga tgttgaattg ggaccctcag cagagaggag

961 gacctgttga ccttactttg aagcagccaa gatgttttgt attaatggat cacattttga

1021 atttgaagat agtacacatc ctaaatatga cttctgcaaa gataatttct tttctgttac

1081 cacctgatga aagtcttcat tcactacagt ctcgtattga gcgtgaaact ggaataaata

1141 ctggttctca agaacttctt tcagagacag gaatttctct ggatcctcgg aaaccagcct

1201 ctcaatgtgt tctagatgga gttagaggct gtgatagcta tatggtttat ttgtttgata

1261 aaagtaaaac tgtatatgaa gggccatttg cttccagaag tttatctgat tgtgtaaatt

1321 atattgtaca ggacagcaaa atacagcttc caattataca gctgcgtaaa gtgtgggctg

1381 aagcagtgca ctatgtgtct ggactaaaag aagactatag caggctcttt cagggacaaa

1441 gggcagcaat gttaagtctt cttagatata atgctaactt aacaaaaatg aagaacactt

1501 tgatctcagc atcacaacaa ctgaaagcta aattggagtt ttttcacaaa agcattcagc

1561 ttgacttgga gagatacagc gagcagatga cgtatgggat atcttcagaa aaaatgctaa

1621 aagcatggaa agaaatggaa gaaaaggcca tccactatgc tgaggttggt gtcattggat

1681 acctggagga tcagattatg tctttgcatg ctgaaatcat ggagctacag aagagcccct

1741 atggaagacg tcagggagac ttgatggaat ctctggaaca gcgtgccatt gatctatata

1801 agcagttaaa acacagacct tcagatcact cctacagtga cagcacagag atggtgaaaa

1861 tcattgtgca cactgtgcag agtcaggacc gtgtgctcaa ggagctgttt ggtcatttga

1921 gcaagttgtt gggctgtaag cagaagatta ttgatctact ccctaaggtg gaagtggccc

1981 tcagtaatat caaagaagct gacaatactg tcatgttcat gcagggaaaa aggcagaaag

2041 aaatatggca tctccttaaa attgcctgta cacagagttc tgcccggtcc cttgtaggat

2101 ccagtctaga aggtgcagta acccctcaga catcagcatg gctgcccccg acttcagcag

2161 aacatgatca ttctctgtca tgtgtggtaa ctcctcaaga tggggagact tcagcacaaa

2221 tgatagaaga aaatttgaac tgccttggcc atttaagcac tattattcat gaggcaaatg

2281 aggaacaggg caatagtatg atgaatcttg attggagttg gttaacagaa tgagttgtca

2341 cttgttcact gtccccaaac ctatggaagt tgttgctata catgttggaa atgtgttttt

2401 cccccatgaa accattcttc agacatcagt caatggaaga aatggctatg aacagaaact

2461 acatttctac tatgatcaga agaacatgat tttacaagta taacagtttt gagtaattca

2521 agcctctaaa cagacaggaa tttagaaaaa gtcaatgtac ttgtttgaat atttgtttta

2581 ataccacagc tatttagaag catcatcacg acacatttgc cttcagtctt ggtaaaacat

2641 tacttattta actgattaaa aataccttct atgtattagt gtcaactttt aacttttggg

2701 cgtaagacaa agtgtagttt tgtatacaga gaagaaaacc tcaagtaata ggcattttaa

2761 gtaaaagtct acctgtgttt ttttctaaaa aggctgctca caagttctat ttcttgaaga

2821 ataaattcta cctccttgtg ttgcactgaa caggttctct tcctggcatc ataaggagtt

2881 ggtgtaatca ttttaaattc cactgaaaat ttaacagtat ccccttctca tcgaagggat

2941 tgtgtatctg tgcttctaat attagttggc tttcataaat catgttgttg tgtgtatatg

3001 tatttaagat gtacatttaa taatatcaaa gagaagatgc ctgttaattt ataatgtatt

3061 tgaaaattac atgttttttc atttgtaaaa atgagtcatt tgtttaaaca atctttcatg

3121 tcttgtcata caaatttata aaggtctgca ctcctttatc tgtaattgta attccaaaat

3181 ccaaaaagct ctgaaaacaa ggtttccata agcttggtga caaaattcat ttgcttgcaa

3241 tctaatctga actgaccttg aatcttttta tcccatttag tgtgaatatt cctttatttt

3301 gctgcttgat gatgagaggg agggctgctg ccacagactg tggtgagggc tggttaatgt

3361 agtatggtat atgcacaaaa ctacttttct aaaatctaaa atttcataat tctgaaacaa

3421 cttgccccaa gggtttcaga gaaaggactg tggacctcta tcatctgcta agtaatttag

3481 aagatattat ttgtcttaaa aaatgtgaaa tgcttttata ttctaatagt ttttcacttt

3541 gtgtattaaa tggtttttaa attaaaaaaa aaaaaaaaa EPI-109 968

(2) INFORMATION FOR SEQ ID NO: 2715: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2715

1 gcccgcgtta agattcccgc attttaatgt tttcaggggg gtgtcatagc cccgggtttg

61 gccgccccag ccccgccttc cccgccccgg ggagcccgcc cccttccccg cgtccctgcc

121 gacagagtta gcacgacatc agtatgagct ggtcaccttc cctgacaacg cagacatgtg

181 gggcctggga aatgaaagag cgccttggga cagggggatt tggaaatgtc atccgatggc

241 acaatcagga aacaggtgag cagattgcca tcaagcagtg ccggcaggag ctcagccccc

301 ggaaccgaga gcggtggtgc ctggagatcc agatcatgag aaggctgacc caccccaatg

361 tggtggctgc ccgagatgtc cctgagggga tgcagaactt ggcgcccaat gacctgcccc

421 tgctggccat ggagtactgc caaggaggag atctccggaa gtacctgaac cagtttgaga

481 actgctgtgg tctgcgggaa ggtgccatcc tcaccttgct gagtgacatt gcctctgcgc

541 ttagatacct tcatgaaaac agaatcatcc atcgggatct aaagccagaa aacatcgtcc

601 tgcagcaagg agaacagagg ttaatacaca aaattattga cctaggatat gccaaggagc

661 tggatcaggg cagtctttgc acatcattcg tggggaccct gcagtacctg gccccagagc

721 tactggagca gcagaagtac acagtgaccg tcgactactg gagcttcggc accctggcct

781 ttgagtgcat cacgggcttc cggcccttcc tccccaactg gcagcccgtg cagtggcatt

841 caaaagtgcg gcagaagagt gaggtggaca ttgttgttag cgaagacttg aatggaacgg

901 tgaagttttc aagctcttta ccctacccca ataatcttaa cagtgtcctg gctgagcgac

961 tggagaagtg gctgcaactg atgctgatgt ggcacccccg acagaggggc acggatccca

1021 cgtatgggcc caatggctgc ttcaaggccc tggatgacat cttaaactta aagctggttc

1081 atatcttgaa catggtcacg ggcaccatcc acacctaccc tgtgacagag gatgagagtc

1141 tgcagagctt gaaggccaga atccaacagg acacgggcat cccagaggag gaccaggagc

1201 tgctgcagga agcgggcctg gcgttgatcc ccgataagcc tgccactcag tgtatttcag

1261 acggcaagtt aaatgagggc cacacattgg acatggatct tgtttttctc tttgacaaca

1321 gtaaaatcac ctatgagact cagatctccc cacggcccca acctgaaagt gtcagctgta

1381 tccttcaaga gcccaagagg aatctcgcct tcttccagct gaggaaggtg tggggccagg

1441 tctggcacag catccagacc ctgaaggaag attgcaaccg gctgcagcag ggacagcgag

1501 ccgccatgat gaatctcctc cgaaacaaca gctgcctctc caaaatgaag aattccatgg

1561 cttccatgtc tcagcagctc aaggccaagt tggatttctt caaaaccagc atccagattg

1621 acctggagaa gtacagcgag caaaccgagt ttgggatcac atcagataaa ctgctgctgg

1681 cctggaggga aatggagcag gctgtggagc tctgtgggcg ggagaacgaa gtgaaactcc

1741 tggtagaacg gatgatggct ctgcagaccg acattgtgga cttacagagg agccccatgg

1801 gccggaagca ggggggaacg ctggacgacc tagaggagca agcaagggag ctgtacagga

1861 gactaaggga aaaacctcga gaccagcgaa ctgagggtga cagtcaggaa atggtacggc

1921 tgctgcttca ggcaattcag agcttcgaga agaaagtgcg agtgatctat acgcagctca

1981 gtaaaactgt ggtttgcaag cagaaggcgc tggaactgtt gcccaaggtg gaagaggtgg

2041 tgagcttaat gaatgaggat gagaagactg ttgtccggct gcaggagaag cggcagaagg

2101 agctctggaa tctcctgaag attgcttgta gcaaggtccg tggtcctgtc agtggaagcc

2161 cggatagcat gaatgcctct cgacttagcc agcctgggca gctgatgtct cagccctcca

2221 cggcctccaa cagcttacct gagccagcca agaagagtga agaactggtg gctgaagcac

2281 ataacctctg caccctgcta gaaaatgcca tacaggacac tgtgagggaa caagaccaga

2341 gtttcacggc cctagactgg agctggttac agacggaaga agaagagcac agctgcctgg

2401 agcaggcctc atgatgtggg gggactcgac cccctgacat ggggcagccc atagcaggcc

2461 ttgtgcagtg gggggactcg accccctgac atggggctgc ctggagcagg ccgcgtgacg

2521 tggggctgcc tggccgcggc tctcacatgg tggttcctgc tgcactgatg gcccaggggt

2581 ctctggtatc cagatggagc tctcgcttcc tcagcagctg tgactttcac ccaggaccca

2641 ggacgcagcc ctccgtgggc actgccggcg ccttgtctgc acactggagg tcctccatta

2701 cagaggccca gcgcacatcg ctggccccac aaacgttcag gggtacagcc atggcagctc

2761 cttcctctgc cgtgagaaaa gtgcttggag tacggtttgc cacacacgtg actggacagt

2821 gtccaattca aatctttcag ggcagagtcc gagcagcgct tggtgacagc ctgtcctctc

2881 ctgctctcca aaggccctgc tccctgtcct ctctcacttt acagcttgtg tttcttctgg

2941 attcagcttc tcctaaacag acagtttaat tatagttgcg gcctggcccc atcctcactt

3001 cctcttttta tttcactgct gctaaaattg tgtttttacc tacaaaaaaa aaaaaaaa

(2) INFORMATION FOR SEQ ID NO: 2716: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi)SEQUENCE DESCRIPTION: SEQ ID NO:2716

1 ggcacgagca tggcccttgt gatccaggtg gggaaactaa ggcccagaga agtgaggacc 61 ccgcagacta tcaatcccag tctcttcccc tcactccctg tgaagctctc cagcatcatc EPI-109 969

121 gaggtcccat cagcccttgc cctgttggat gaataggcac ctctggaaga gccaactgtg

181 tgagatggtg cagcccagtg gtggcccggc agcagatcag gacgtactgg gcgaagagtc

241 tcctctgggg aagccagcca tgctgcacct gccttcagaa cagggcgctc ctgagaccct

301 ccagcgctgc ctggaggaga atcaagagct ccgagatgcc atccggcaga gcaaccagat

361 tctgcgggag cgctgcgagg agcttctgca tttccaagcc agccagaggg aggagaagga

421 gttcctcatg tgcaagttcc aggaggccag gaaactggtg gagagactcg gcctggagaa

481 gctcgatctg aagaggcaga aggagcaggc tctgcgggag gtggagcacc tgaagagatg

541 ccagcagcag atggctgagg acaaggcctc tgtgaaagcc caggtgacgt ccttgctcgg

601 ggagctgcag gagagccaga gtcgcttgga ggctgccact aaggaatgcc aggctctgga

661 gggtcgggcc cgggcggcca gcgagcaggc gcggcagctg gagagtgagc gcgaggcgct

721 gcagcagcag cacagcgtgc aggtggacca gctgcgcatg cagggccaga gcgtggaggc

781 cgcgctccgc atggagcgcc aggccgcctc ggaggagaag aggaagctgg cccagttgca

841 ggtggcctat caccagctct tccaagaata cgacaaccac atcaagagca gcgtggtggg

901 cagtgagcgg aagcgaggaa tgcagctgga agatctcaaa cagcagctcc agcaggccga

961 ggaggccctg gtggccaaac aggaggtgat cgataagctg aaggaggagg ccgagcagca

1021 caagattgtg atggagaccg ttccggtgct gaaggcccag gcggatatct acaaggcgga

1081 cttccaggct gagaggcagg cccgggagaa gctggccgag aagaaggagc tcctgcagga

1141 gcagctggag cagctgcaga gggagtacag caaactgaag gccagctgtc aggagtcggc

1201 caggatcgag gacatgagga agcggcatgt cgaggtctcc caggccccct tgccccccgc

1261 ccctgcctac ctctcctctc ccctggccct gcccagccag aggaggagcc cccccgagga

1321 gccacctgac ttctgctgtc ccaagtgcca gtatcaggcc cctgatatgg acaccctgca

1381 gatacatgtc atggagtgca ttgagtaggg ccggccagtg caaggccact gcctgcccga

1441 ggacgtgccc gggaccgtgc agtctgcgct ttcctctccc gcctgcctag cccaggatga

1501 agggctgggt ggccacaact gggatgccac ctggagcccc acccaggagc tggccgcggc

1561 accttacgct tcagctgttg atccgctggt cccctctttt ggggtagatg cggccccgat

1621 caggcctgac tcgctgctct ttttgttccc ttctgtctgc tcgaaccact tgcctcgggc

1681 taatccctcc ctcttcctcc acccggcact ggggaagtca agaatggggc ctggggctct

1741 cagggagaac tgcttcccct ggcagagctg ggtggcagct cttcctccca ccggacaccg

1801 acccgcccgc cgctgtgccc tgggagtgct gccctcttac catgcacacg ggtgctctcc

1861 ttttgggctg catgctattc cattttgcag ccagaccgat gtgtatttaa ccagtcacta

1921 ttgatggaca tttgggttgt ttcccatctt tttgttacca taaataatgg catagtaaaa

1981 aaaaaaaaaa aaaa

(2) INFORMATION FOR SEQ ID NO: 2717: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2717

1 cacgcgtccg cgagaaggag gactcgcaag cctcggcggc ccggaaccgg cctcggactg

61 tcgacggaac ctgaggccgc ttgccctccc gccccatgga gcggcccccg gggctgcggc

121 cgggcgcggg cgggccctgg gagatgcggg agcggctggg caccggcggc ttcgggaacg

181 tctgtctgta ccagcatcgg gaacttgatc tcaaaatagc aattaagtct tgtcgcctag

241 agctaagtac caaaaacaga gaacgatggt gccatgaaat ccagattatg aagaagttga

301 accatgccaa tgttgtaaag gcctgtgatg ttcctgaaga attgaatatt ttgattcatg

361 atgtgcctct tctagcaatg gaatactgtt ctggaggaga tctccgaaag ctgctcaaca

421 aaccagaaaa ttgttgtgga cttaaagaaa gccagatact ttctttacta agtgatatag

481 ggtctgggat tcgatatttg catgaaaaca aaattataca tcgagatcta aaacctgaaa

541 acatagttct tcaggatgtt ggtggaaaga taatacataa aataattgat ctgggatatg

601 ccaaagatgt tgatcaagga agtctgtgta catcttttgt gggaacactg cagtatctgg

661 ccccagagct ctttgagaat aagccttaca cagccactgt tgattattgg agctttggga

721 ccatggtatt tgaatgtatt gctggatata ggcctttttt gcatcatctg cagccattta

781 cctggcatga gaagattaag aagaaggatc caaagtgtat atttgcatgt gaagagatgt

841 caggagaagt tcggtttagt agccatttac ctcaaccaaa tagcctttgt agtttaatag

901 tagaacccat ggaaaactgg ctacagttga tgttgaattg ggaccctcag cagagaggag

961 gacctgttga ccttactttg aagcagccaa gatgttttgt attaatggat cacattttga

1021 atttgaagat agtacacatc ctaaatatga cttctgcaaa gataatttct tttctgttac

1081 cacctgatga aagtcttcat tcactacagt ctcgtattga gcgtgaaact ggaataaata

1141 ctggttctca agaacttctt tcagagacag gaatttctct ggatcctcgg aaaccagcct

1201 ctcaatgtgt tctagatgga gttagaggct gtgatagcta tatggtttat ttgtttgata

1261 aaagtaaaac tgtatatgaa gggccatttg cttccagaag tttatctgat tgtgtaaatt

1321 atattgtaca ggacagcaaa atacagcttc caattataca gctgcgtaaa gtgtgggctg

1381 aagcagtgca ctatgtgtct ggactaaaag aagactatag caggctcttt cagggacaaa

1441 gggcagcaat gttaagtctt cttagatata atgctaactt aacaaaaatg aagaacactt

1501 tgatctcagc atcacaacaa ctgaaagcta aattggagtt ttttcacaaa agcattcagc

1561 ttgacttgga gagatacagc gagcagatga cgtatgggat atcttcagaa aaaatgctaa

1621 aagcatggaa agaaatggaa gaaaaggcca tccactatgc tgaggttggt gtcattggat EPI-109 970

1681 acctggagga tcagattatg tctttgcatg ctgaaatcat ggagctacag aagagcccct

1741 atggaagacg tcagggagac ttgatggaat ctctggaaca gcgtgccatt gatctatata

1801 agcagttaaa acacagacct tcagatcact cctacagtga cagcacagag atggtgaaaa

1861 tcattgtgca cactgtgcag agtcaggacc gtgtgctcaa ggagctgttt ggtcatttga

1921 gcaagttgtt gggctgtaag cagaagatta ttgatctact ccctaaggtg gaagtggccc

1981 tcagtaatat caaagaagct gacaatactg tcatgttcat gcagggaaaa aggcagaaag

2041 aaatatggca tctccttaaa attgcctgta cacagagttc tgcccggtcc cttgtaggat

2101 ccagtctaga aggtgcagta acccctcaga catcagcatg gctgcccccg acttcagcag

2161 aacatgatca ttctctgtca tgtgtggtaa ctcctcaaga tggggagact tcagcacaaa

2221 tgatagaaga aaatttgaac tgccttggcc atttaagcac tattattcat gaggcaaatg

2281 aggaacaggg caatagtatg atgaatcttg attggagttg gttaacagaa tgagttgtca

2341 cttgttcact gtccccaaac ctatggaagt tgttgctata catgttggaa atgtgttttt

2401 cccccatgaa accattcttc agacatcagt caatggaaga aatggctatg aacagaaact

2461 acatttctac tatgatcaga agaacatgat tttacaagta taacagtttt gagtaattca

2521 agcctctaaa cagacaggaa tttagaaaaa gtcaatgtac ttgtttgaat atttgtttta

2581 ataccacagc tatttagaag catcatcacg acacatttgc cttcagtctt ggtaaaacat

2641 tacttattta actgattaaa aataccttct atgtattagt gtcaactttt aacttttggg

2701 cgtaagacaa agtgtagttt tgtatacaga gaagaaaacc tcaagtaata ggcattttaa

2761 gtaaaagtct acctgtgttt ttttctaaaa aggctgctca caagttctat ttcttgaaga

2821 ataaattcta cctccttgtg ttgcactgaa caggttctct tcctggcatc ataaggagtt

2881 ggtgtaatca ttttaaattc cactgaaaat ttaacagtat ccccttctca tcgaagggat

2941 tgtgtatctg tgcttctaat attagttggc tttcataaat catgttgttg tgtgtatatg

3001 tatttaagat gtacatttaa taatatcaaa gagaagatgc ctgttaattt ataatgtatt

3061 tgaaaattac atgttttttc atttgtaaaa atgagtcatt tgtttaaaca atctttcatg

3121 tcttgtcata caaatttata aaggtctgca ctcctttatc tgtaattgta attccaaaat

3181 ccaaaaagct ctgaaaacaa ggtttccata agcttggtga caaaattcat ttgcttgcaa

3241 tctaatctga actgaccttg aatcttttta tcccatttag tgtgaatatt cctttatttt

3301 gctgcttgat gatgagaggg agggctgctg ccacagactg tggtgagggc tggttaatgt

3361 agtatggtat atgcacaaaa ctacttttct aaaatctaaa atttcataat tctgaaacaa

3421 cttgccccaa gggtttcaga gaaaggactg tggacctcta tcatctgcta agtaatttag

3481 aagatattat ttgtcttaaa aaatgtgaaa tgcttttata ttctaatagt ttttcacttt 3541 gtgtattaaa tggtttttaa attaaaaaaa aaaaaaaaa

1 gcccgcgtta agattcccgc attttaatgt tttcaggggg gtgtcatagc cccgggtttg

61 gccgccccag ccccgccttc cccgccccgg ggagcccgcc cccttccccg cgtccctgcc

121 gacagagtta gcacgacatc agtatgagct ggtcaccttc cctgacaacg cagacatgtg

181 gggcctggga aatgaaagag cgccttggga cagggggatt tggaaatgtc atccgatggc

241 acaatcagga aacaggtgag cagattgcca tcaagcagtg ccggcaggag ctcagccccc

301 ggaaccgaga gcggtggtgc ctggagatcc agatcatgag aaggctgacc caccccaatg

361 tggtggctgc ccgagatgtc cctgagggga tgcagaactt ggcgcccaat gacctgcccc

421 tgctggccat ggagtactgc caaggaggag atctccggaa gtacctgaac cagtttgaga

481 actgctgtgg tctgcgggaa ggtgccatcc tcaccttgct gagtgacatt gcctctgcgc

541 ttagatacct tcatgaaaac agaatcatcc atcgggatct aaagccagaa aacatcgtcc

601 tgcagcaagg agaacagagg ttaatacaca aaattattga cctaggatat gccaaggagc

661 tggatcaggg cagtctttgc acatcattcg tggggaccct gcagtacctg gccccagagc

721 tactggagca gcagaagtac acagtgaccg tcgactactg gagcttcggc accctggcct

781 ttgagtgcat cacgggcttc cggcccttcc tccccaactg gcagcccgtg cagtggcatt

841 caaaagtgcg gcagaagagt gaggtggaca ttgttgttag cgaagacttg aatggaacgg

901 tgaagttttc aagctcttta ccctacccca ataatcttaa cagtgtcctg gctgagcgac

961 tggagaagtg gctgcaactg atgctgatgt ggcacccccg acagaggggc acggatccca

1021 cgtatgggcc caatggctgc ttcaaggccc tggatgacat cttaaactta aagctggttc

1081 atatcttgaa catggtcacg ggcaccatcc acacctaccc tgtgacagag gatgagagtc

1141 tgcagagctt gaaggccaga atccaacagg acacgggcat cccagaggag gaccaggagc

1201 tgctgcagga agcgggcctg gcgttgatcc ccgataagcc tgccactcag tgtatttcag

1261 acggcaagtt aaatgagggc cacacattgg acatggatct tgtttttctc tttgacaaca

1321 gtaaaatcac ctatgagact cagatctccc cacggcccca acctgaaagt gtcagctgta

1381 tccttcaaga gcccaagagg aatctcgcct tcttccagct gaggaaggtg tggggccagg

1441 tctggcacag catccagacc ctgaaggaag attgcaaccg gctgcagcag ggacagcgag

1501 ccgccatgat gaatctcctc cgaaacaaca gctgcctctc caaaatgaag aattccatgg

1561 cttccatgtc tcagcagctc aaggccaagt tggatttctt caaaaccagc atccagattg

1621 acctggagaa gtacagcgag caaaccgagt ttgggatcac atcagataaa ctgctgctgg

1681 cctggaggga aatggagcag gctgtggagc tctgtgggcg ggagaacgaa gtgaaactcc

1741 tggtagaacg gatgatggct ctgcagaccg acattgtgga cttacagagg agccccatgg

1801 gccggaagca ggggggaacg ctggacgacc tagaggagca agcaagggag ctgtacagga

1861 gactaaggga aaaacctcga gaccagcgaa ctgagggtga cagtcaggaa atggtacggc

1921 tgctgcttca ggcaattcag agcttcgaga agaaagtgcg agtgatctat acgcagctca

1981 gtaaaactgt ggtttgcaag cagaaggcgc tggaactgtt gcccaaggtg gaagaggtgg

2041 tgagcttaat gaatgaggat gagaagactg ttgtccggct gcaggagaag cggcagaagg

2101 agctctggaa tctcctgaag attgcttgta gcaaggtccg tggtcctgtc agtggaagcc EPI-109 971

2161 cggatagcat gaatgcctct cgacttagcc agcctgggca gctgatgtct cagccctcca

2221 cggcctccaa cagcttacct gagccagcca agaagagtga agaactggtg gctgaagcac

2281 ataacctctg caccctgcta gaaaatgcca tacaggacac tgtgagggaa caagaccaga

2341 gtttcacggc cctagactgg agctggttac agacggaaga agaagagcac agctgcctgg

2401 agcaggcctc atgatgtggg gggactcgac cccctgacat ggggcagccc atagcaggcc

2461 ttgtgcagtg gggggactcg accccctgac atggggctgc ctggagcagg ccgcgtgacg

2521 tggggctgcc tggccgcggc tctcacatgg tggttcctgc tgcactgatg gcccaggggt

2581 ctctggtatc cagatggagc tctcgcttcc tcagcagctg tgactttcac ccaggaccca

2641 ggacgcagcc ctccgtgggc actgccggcg ccttgtctgc acactggagg tcctccatta

2701 cagaggccca gcgcacatcg ctggccccac aaacgttcag gggtacagcc atggcagctc

2761 cttcctctgc cgtgagaaaa gtgcttggag tacggtttgc cacacacgtg actggacagt

2821 gtccaattca aatctttcag ggcagagtcc gagcagcgct tggtgacagc ctgtcctctc

2881 ctgctctcca aaggccctgc tccctgtcct ctctcacttt acagcttgtg tttcttctgg

2941 attcagcttc tcctaaacag acagtttaat tatagttgcg gcctggcccc atcctcactt

3001 cctcttttta tttcactgct gctaaaattg tgtttttacc tacaaaaaaa aaaaaaaa

1 ggcacgagca tggcccttgt gatccaggtg gggaaactaa ggcccagaga agtgaggacc

61 ccgcagacta tcaatcccag tctcttcccc tcactccctg tgaagctctc cagcatcatc

121 gaggtcccat cagcccttg.c cctgttggat gaataggcac ctctggaaga gccaactgtg

181 tgagatggtg cagcccagtg gtggcccggc agcagatcag gacgtactgg gcgaagagtc

241 tcctctgggg aagccagcca tgctgcacct gccttcagaa cagggcgctc ctgagaccct

301 ccagcgctgc ctggaggaga atcaagagct ccgagatgcc atccggcaga gcaaccagat

361 tctgcgggag cgctgcgagg agcttctgca tttccaagcc agccagaggg aggagaagga

421 gttcctcatg tgcaagttcc aggaggccag gaaactggtg gagagactcg gcctggagaa

481 gctcgatctg aagaggcaga aggagcaggc tctgcgggag gtggagcacc tgaagagatg

541 ccagcagcag atggctgagg acaaggcctc tgtgaaagcc caggtgacgt ccttgctcgg

601 ggagctgcag gagagccaga gtcgcttgga ggctgccact aaggaatgcc aggctctgga

661 gggtcgggcc cgggcggcca gcgagcaggc gcggcagctg gagagtgagc gcgaggcgct

721 gcagcagcag cacagcgtgc aggtggacca gctgcgcatg cagggccaga gcgtggaggc

781 cgcgctccgc atggagcgcc aggccgcctc ggaggagaag aggaagctgg cccagttgca

841 ggtggcctat caccagctct tccaagaata cgacaaccac atcaagagca gcgtggtggg

901 cagtgagcgg aagcgaggaa tgcagctgga agatctcaaa cagcagctcc agcaggccga

961 ggaggccctg gtggccaaac aggaggtgat cgataagctg aaggaggagg ccgagcagca

1021 caagattgtg atggagaccg ttccggtgct gaaggcccag gcggatatct acaaggcgga

1081 cttccaggct gagaggcagg cccgggagaa gctggccgag aagaaggagc tcctgcagga

1141 gcagctggag cagctgcaga gggagtacag caaactgaag gccagctgtc aggagtcggc

1201 caggatcgag gacatgagga agcggcatgt cgaggtctcc caggccccct tgccccccgc

1261 ccctgcctac ctctcctctc ccctggccct gcccagccag aggaggagcc cccccgagga

1321 gccacctgac ttctgctgtc ccaagtgcca gtatcaggcc cctgatatgg acaccctgca

1381 gatacatgtc atggagtgca ttgagtaggg ccggccagtg caaggccact gcctgcccga

1441 ggacgtgccc gggaccgtgc agtctgcgct ttcctctccc gcctgcctag cccaggatga

1501 agggctgggt ggccacaact gggatgccac ctggagcccc acccaggagc tggccgcggc

1561 accttacgct tcagctgttg atccgctggt cccctctttt ggggtagatg cggccccgat

1621 caggcctgac tcgctgctct ttttgttccc ttctgtctgc tcgaaccact tgcctcgggc

1681 taatccctcc ctcttcctcc acccggcact ggggaagtca agaatggggc ctggggctct

1741 cagggagaac tgcttcccct ggcagagctg ggtggcagct cttcctccca ccggacaccg

1801 acccgcccgc cgctgtgccc tgggagtgct gccctcttac catgcacacg ggtgctctcc

1861 ttttgggctg catgctattc cattttgcag ccagaccgat gtgtatttaa ccagtcacta

1921 ttgatggaca tttgggttgt ttcccatctt tttgttacca taaataatgg catagtaaaa

1981 aaaaaaaaaa aaaa

(2) INFORMATION FOR SEQ ID NO: 2718: (i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2718

1 gaattcctct ggtcctcatc caggtgcgcg ggaagcaggt gcccaggaga gaggggataa

61 tgaagattcc atgctgatga tcccaaagat tgaacctgca gaccaagcgc aaagtagaaa

121 ctgaaagtac actgctggcg gatcctacgg aagttatgga aaaggcaaag cgcagagcca

181^' cgccgtagtg tgtgccgccc cccttgggat ggatgaaact gcagtcgcgg cgtgggtaag

241 aggaaccagc tgcagagatc accctgccca acacagactc ggcaactccg cggaagacca

301 gggtcctggg agtgactatg ggcggtgaga gcttgctcct gctccagttg cggtcatcat

361 gactacgccc gcctcccgca gaccatgttc catgtttctt ttaggtatat ctttggactt

421 cctcccctga tccttgttct gttgccagta gcatcatctg attgtgatat tgaaggtaaa

481 gatggcaaac aatatgagag tgttctaatg gtcagcatcg atcaattatt ggacagcatg

541 aaagaaattg gtagcaattg cctgaataat gaatttaact tttttaaaag acatatctgt

601 gatgctaata aggaaggtat gtttttattc cgtgctgctc gcaagttgag gcaatttctt

661 aaaatgaata gcactggtga ttttgatctc cacttattaa aagtttcaga aggcacaaca EPI-109 972

721 atactgttga actgcactgg ccaggttaaa ggaagaaaac cagctgccct gggtgaagcc

781 caaccaacaa agagtttgga agaaaataaa tctttaaagg aacagaaaaa actgaatgac

841 ttgtgtttcc taaagagact attacaagag ataaaaactt gttggaataa aattttgatg

901 ggcactaaag aacactgaaa aatatggagt ggcaatatag aaacacgaac tttagctgca

961 tcctccaaga atctatctgc ttatgcagtt tttcagagtg gaatgcttcc tagaagttac

1021 tgaatgcacc atggtcaaaa cggattaggg catttgagaa atgcatattg tattactaga

1081 agatgaatac aaacaatgga aactgaatgc tccagtcaac aaactatttc ttatatatgt

1141 gaacatttat caatcagtat aattctgtac tgatttttgt aagacaatcc atgtaaggta

1201 tcagttgcaa taatacttct caaacctgtt taaatatttc aagacattaa atctatgaag

1261 tatataatgg tttcaaagat tcaaaattga cattgcttta ctgtcaaaat aattttatgg

1321 ctcactatga atctattata ctgtattaag agtgaaaatt gtcttcttct gtgctggaga

1381 tgttttagag ttaacaatga tatatggata atgccggtga gaataagaga gtcataaacc

1441 ttaagtaagc aacagcataa caaggtccaa gatacctaaa agagatttca agagatttaa

1501 ttaatcatga atgtgtaaca cagtgccttc aataaatggt atagcaaatg ttttgacatg

1561 aaaaaaggac aatttcaaaa aaataaaat

(2) INFORMATION FOR SEQ ID NO:2719: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2719

1 gatcaaaatt tttacctatt atgcatttga tatataaata agtatataaa tgcacacaca

61 gacacagcaa tgatggtgaa cagtcttcat acaattatat ggatgaatct cataaaatgc

121 tgagttaaag aaatcagacc aaagaacata tactgaaaga ttctctctat atacaaagtt

181 caaaaatagg tggaccaatt catggtggtg ttagaaatca gaagagaggc tacctttgtg

241 gggaggggac agtttaatgc ccagaagcgg taaataagga atcctctggg gagtggtaat

301 gatctggatg ctggctacag gatgtgttgg ttgtaaaaat gcattttttt atatctagct

361 ttttccatgt gtatattata cttcaaagaa gttcagttaa taatttctca tgtcactgta

421 gagtagctca gttagcccca gcaagcctct ggcttaatct tgttttacct taagccatca

481 gtcatttaca agtaggaaaa ttcacaggga aagttagagt ataaaatcca gaatgaaggt

541 ttactgggta agagtctctc cattttccaa agcccgttta tttcttgatt ccagttctta

601 agaagtctca gcattgtgtc tttttcatgt atcttacaag aagacagcat gtgcttctaa

661 cacctgatac attgtatcta ccagcacttg gtaaacagaa aagaaccaca tttttcttgt

721 aggagaaatt tggtgcctat ttcctaccag gcaccaataa gtgggaccaa taggtgggat

781 taaagataca gtagaaagta tttaaaactt gccagggggc aatagtctga aaataagtaa

841 attggtgcta tagaatggaa gttacaggct tctttctttt ttcccacaag atctgctcct

901 tgagccccta gagacttttc tgtctgttac tgtttcttca ttcctcatct gcagagccag

961 ccctgagaag tgcagaccaa agccagggaa ggctctgcaa agatgtacaa atggaagtca

1021 ccttaataac ctctgactgc tgcgcataat acatttcact caaaagaggg gttaaacaat

1081 ggaacagaat acagaggcca gaaataatgc tgaacactga caaccatctg atctttgaca

1141 aaatccacaa aaacaagcaa tggagaaagg actccctatt ccataatggt gctgggataa

1201 ctgtctagct atatacagaa gattgaacct gggccccttc cttacatcat atacaaaaaa

1261 taactcaaga tggagtaaag acttaaatct aaaaccaaac actataaaaa ccctggaaga

1321 tagcctggga aataccattc tggacatagg acctggcaaa gacttcatga caagacacca

1381 aaagcaatag caacaaaaac caaattgact aatgaaacta atgaaactct ttagttgtac

1441 aacagatagt ttatctgtac aacaaaataa actatcaaca gagtaaacaa cctacagaat

1501 ggaaaaattt tttgcaaact atgcatctga caaaggtcta atatccagaa tctataagga

1561 atttaaacaa atttacaagc aaaaaaatga cctcattaaa aagtgggcaa aggacatgaa

1621 cagatgcttt tcaaaataag acattcacac atccaacaac catatgaaaa gatgtttaac

1681 atcactaatc attagaggaa tacaaatcaa aagcataata agataccatc taataccagt

1741 aggaatgact actattaaaa agtcagacaa taacagatgc tggtgaaggt tgtggagaaa

1801 agggaatgtt tatgcactgc tagtgggaat gtaaactagt tcagccattg tggaagagag

1861 tgtggtgatt cctcaaagaa tgtaaaaccg aactgccttt caatccagca atcccattat

1921 tggatataca ccaaaaggaa tagaaattgt tttaccgtaa aggcgcatgc atgcatatgt

1981 tcattacagc actatttacg atagcaaaga catggaatcg tctaaatgcc catcagtggt

2041 agactagcta aaaaaaaaaa aatgtggtac atatacatca cagaatagta tgcagccata

2101 aaaatgaaca agatcatcat gtcctttgca gcaacatgga tgtagttgga ggccattatc

2161 ctaagcaaat taatgcagga acagaaagcc aaataccaca tgttctcatt tataagtgac

2221 agctaaatat tgagtacaca tggacacaaa gaagggaaca atagacatgg gacctacttg

2281 agaatagagg gtgggaggag ggtgaggatc aaaaagtacc cataggacac tgtgcttatt

2341 acctgggtga tgaaataatt tgcacaccaa acccctgtga cacacaattt acctatatag

2401 aaaacctgtg catgtacccc tgaacctaaa agttaatggt gggggggtgg ggttaagcta

2461 ctttgtggta taaatctgag cattcatatt aaaataaaat atttacctca ttagagtaat

2521 taacatttat taagcaaaga gccaagtacc ttacacacat gatgtttaat ctcacaatga

2581 tctttaatct cataacaacc gtccattgta tgtacatatg tggaaattga gccttggaga

2641 gattaaatgc atggggcatg ccatttgact agaaactgga agcatcagga tttaaactca

2701 gttctgaatg gttttgtagg ctttgttttt tccacattat agcatggcct gccatgaaga

2761 acaggtcctt tctggtgttt gtcttgtttg gtttaagtga agcaaatatt tatttaaata

2821 ttcaagatat gctgttaaat ttttactcaa aaatttgagt acagtatgga tcttctgaag

2881 ccaaataact cttattcaat gcttagttga gaaattttat ggagtagttc tcaattttta

2941 tgtagttcca ctgcaaaggt aagtcttatg gaaagattca ctgtaatttt ttttcctcat EPI-109 973

3001 ttggacatca gctttttctt ttcctcagac ccgctgaaag ataattttta aaataaaaac 3061 cttgttttta tatcaagtgg ggacattttt tccaaatgaa aaccgtgtat tcattttata 3121 tgataaaatc aatgttatta tttttaaaat tttgatttaa aaatcattaa aaataaattt 3181 tcagatatta cctgaaattc taccatccag agataatagt gcttaaagat ttgatatata 3241 gacacacaca catatataca tatatatcat cctaaacttc tttgtataaa tgtatataaa 3301 gtttttaata aaaactagga gattaatgcc ctttgaatga aaataaatac aatgtgtatg 3361 ctttaacatc ttgcctttac tttataacat ttatcacagc agtcatgaga taatgattta 3421 catggtcatt gttagtaagc taatagctaa gtgcatgaac tctggagcta gcctccctgg 3481 attttaatcc cagatctgtc actgaccagc tgagcaatac taggtaaatt gctcttgttc 3541 cttagtttct tcatctgtaa aatagagata aaaataatat ccacctcata ggattggtgt 3601 gagcattaaa tgagcatacg tatgtaggcc acttaacaac aatgccttca catactgaac 3661 acaaatatac gagctgttgt cttattgggc tcatgttttt cctaccacta agccgcatgc 3721 atgcaaggac catgttggtt ttgttccaca ttgcatcccc aacctggtat acagtgtgca 3781 ttcaatagtt gttgactatt attactagtg gcatttaaca aatatctgtt aaatgagtga 3841 agaaataccc atttactgca agtgtgtcta atattgatgg cataatgggg gaaactcaaa 3901 ctctggagtc aaacaggttt taaaacctta ttccctcatc ctcagttatt gacgtttttt 3961 ttttggcagg tgtgtgtgtg ggacaactta ttgaactttt ctgaatttcc agcttcgcat 4021 atataaaata gagatagtga ttcattcttg caatgtatgg atttgagaca attgtgtaag 4081 tttatcaata aatagtagct atttttgtat aagtattaca tataatatcc aggccactgc 4141 tttgcataac ccaaaagggg caccattcat gcagaataca acataaatgg tgtccctgga 4201 gcagtgcagt ataggaaccc tgaggggacc tacagtatac tttatagttc atagattaca 4261 aattatccct ttatcagagt ctctcaaggt tggatgtatt tgaggtccat aagagcaatt 4321 taggattaac agtagctgca gaaaccatct gcagtgatat tctcatttta aatccgcggg 4381 aaagaagaca gctataaact tgggacctgg gtttaagcat tttaaatgcc aagttcacca 4441 ttttctaaaa cacaacaaat acccagtgag agagggagaa gggaagtaaa tgcctctgaa 4501 taagcaagtt aatgtcagta gttgtactgt atgcatattg atgaacaata gaggaaccaa 4561 tgtccaatca gatgagcagg atatttggca ataacaagtt gcctttgagg aaaaatgatt 4621 ttcttggcaa gttctttatc agcattacaa agctaaaagc tacgcttatc atcacttata 4681 ctagcatacc ctgttgtgca aatgctgtct gtgtttgcat ctgctattgt tgatgcctgg 4741 tgcatgaatc aggactccag cccacaagtt ttcccagaac tttcttatgg ccatcatctt 4801 taagtgtctg gtgaacagtc atagtttggt acacaaaagg gtcaacctgg gggatggcta 4861 gggtttgact cagtcgttac atttcaatag agcaggaagg ggaaatggtg gcctgtaacc 4921 tcagggaatt ttgccagttg gtccacccca ctctctctct cctgctctga ggaagtggca 4981 cagcctagaa cagcaccaca ggtgagagaa atgcaaaccc taaccagaga agcagactct 5041 ttgccagtag taatagttca ggaccaccac cagcttttat taaaattttt aataacactc 5101 aagtattggc agaaagaaat aatcttgggt taactataac tagaatattg actcttcctc 5161 tgtggaagaa tcagccaatc acatttgttt acatcagttc ccctgaagaa gaaaaataca 5221 ctgatgttgc agcaagacaa atttaagcta gatgtaaata acttccttta gcctgtaatg 5281 ctaggctaat tacatattgg aactattttt tcagggaaga attgtgtagg gtttcaggga 5341 agaattctga agaaaatata gagctgaaat gatcttgcag ctcactgaaa ctgcagggtt 5401 tagatccaca ctgatactcg ttctattatc actgtaatga aggctgatgg aataagtaaa 5461 aatgttttgt attagtatgt ttttacactt atttgcaagg cataaatagg ttaggttttg 5521 atcttaattt aattctaaca tgtattgtgc acaagctgtg agcagttttc aggagttagg 5581 tatctggcca tgactgattt ttcaggagtt aatcatctgg tagaagggtc atacacaata 5641 ggaagatgtg tgtgacaggt tgtgatcatt actataatca cacagagagc tgtagaattt 5701 taggctggca gggtggctca cgcctgtaat cccagcactt tgggaggcca aggcaggcgg 5761 atcaagaggt caggagatgg agaccatcct ggctaacacg gtgaaacccc gtctgtacta 5821 aaaatacaaa aaaaaaaaaa agccaggcgt ggtggtgggc gcctgtagtc ccagctactt 5881 gggaggctga ggcaggagaa tggcgtgaac ccgggaggtg gagcttgcag tgagccgaga 5g41 tcgcatcact gcaatccaac ctgggcgaca gagggagact cagtctcaaa aaaaaaaaaa 6001 aaaaaaagtc atgttagatc cagaggggta gcaactgggg ctgggctgtc agtcaactca 6061 gtcaactcag tcaactctgc tcccccacag gagatgccag tgatgcattt tcatggccaa 6121 cattgtcagt cagcatcatt gaattactcc tgattataga gacacagctg caaacgattc 6181 cccattaaat atgatgtttc ttgcaatgtt tggaaggtac tcctttttag taagggaaat 6241 cccctcttct ggcttgctga aagttttttc tttccatttt aaaaatcgtg aattcctttt 6301 tgcaatattg aggtggttat atggtttctc ttctctaatc tgttaatatg gtgatttaat 6361 ggttagaaat tttctaatgt aaattccact catattgcag aaataaacct aaactgagca 6421 tgaggctata ttttttattt gcttctatat ttggttgcta tacagtatta tgtttaagat 6481 ttgttcacat atatttgtga atgggattgg actatttttc cttcttgccg atttttatct 6541 ggtttttaaa ttaaggatat tttagactta tgaaatattt ggcaaacaat ccttggcaag 6601 taattttttg gggaatttgt tttggctatt ttgagtatta cccaatatat tttaattaag 6661 ttattcttaa tgttttctta attaaaaaaa ttacctactc tagagatatt ctttatgtac 6721 tccagatttt gtctatttat accacttttc ttttttcctc gatgagtgtc atagatgttc 6781 atctattttt ttatcttctt tgatcttctc ttattccttg tttctattaa cttctgaagt 6841 ttattatttt cttttttcca cttccttatg gtttattctt tcaatttttc tctaacttct 6901 taagttgggt gtttaatttt tagcttgctt tgctttttta ggataagcat taaaactaca 6961 aattttcctt gttattcttt tgctgcaccc caaattgttg atatttctat tgtctaattt 7021 ctattcaatt agaatacttt aaagtttctt tttggttttt aaaaactaac tttttaaatt 7081 gacaaataaa aattgtgtat atttattgtg cacagcatat ggctttgaaa tatatgtaca 7141 ttgtggaatg gctaaattta gcttattaat gtatgcatta tctcacatac ttatcatttt 7201 ttgtggtgag agctatgtga cttttgaact tatgagttat ttaaatattt ttaaattatt 7261 aagcatattg ggattttaag taatttacct ttttattatt aacttataac aagtagaaca 7321 gttaacctgt atgattctac atcattgaaa tttattgaca tttgcttcat agtctattat 7381 atggtctact tttgttcatg ttacatctgt agtagaattg gctaatagtt gagtaaagta 7441 cacatatgtc tatgaaatca agtgtaatcc agagaaaaag agaaatttac tgaatatatt EPI-109 974

7501 gttctaggtg ctattatatg ttgtcatgtt taatcctcac cacaattgta tgaggcagcc

7561 ataattaatt ccactttaca catgaggagc ctgagggtta aaaaaaaagc tagctctact

7621 atttgtaaag aatgaagcaa agatacaaat gaaggcccac atatcctata actagatatt

7681 taagcatttt aattcaagct ttaaaactgc taaataaaat gtgctccaat ttctatattg

7741 acagacatac cttcctaatg agctggggtt cgaatttaga aatctttgat gcttcagagt

7801 ccacactgaa atgtggaggc acatagtgag ttggtcccca gccttcagtc cacccacctt

7861 ctctttacta aatcaccttt cacatacatg tatgaacacc ccagcctcca agtccaaacc

7921 ctaaacaaaa tgggacaccc ttgtgcatac acagagacac agcccatcct caggaaaacc

7981 tggaaaagtc catacaagtt ctggaagcaa gcttgggacg gtttcagtag tgtggtctat

8041 aagggaggcc tcagaagaca ggttttctta attctgtgaa cttctcccac agtagaaagg

8101 gtgctggagg agggtcagag tgaggacttc taaagcatgg gtcctgagta ggggccactc

8161 ttgcccaagt ctaagaaggg tactagaata gcacactact actagatact agaacccaga

8221 tacaagcaca ggtcttctga aattaataat aataataact attaccatta ttataccagt

8281 agctgtcatt tatttagtgc ttattatttg ccagtcactg ttctaaattc tttacatgta

8341 ttatacaact gccatataac tgccatatga gggatgtacc ctcattgtca ccattttacc

8401 gatgagaaaa ctggcataaa acgtttaagt aacttgtcca agttacagag cttagtgaag

8461 ccacaatgtt gctcaatttg ctctcaaact tcaaagggat gggaaggaca cctaagtcat

8521 agagtcttta agaatcagag ctagaaggaa tcttagatgt tatctagtca gcctcctccc

8581 attacagtcc aagagaagat ggccctgagt tacttgtagc tatttttgca tgtgaattgc

8641 aagtgaatat acattctact gaagataaaa gatatttaaa gatatcgctg gatataggaa

8701 cagtggtttt aaatctctag gctttaactt ttctcagaac aagaaatcct ttttggtttt

8761 aatctatatg cacatctgta tttttctcaa ttatcgggta gtaaaatata acttttcttc

8821 tgtaatattt tttaacttta atgagtgttc ctcataatag aaaagtttgg aaaccattgc

8881 tatgggtata tactttctaa agggatagta atttctctag aatattcatt taatgctcca

8941 gaagtaatta gcacaattgt gcaagtctgt gcatcatcaa ctatacattc tgcctgttta

9001 ctccaaatcc acatgaaact gattatacag tcaaaggcga gcccagtgga gaggcatttt

9061 tggagacttc ctggtacatt gagacagggt cggccagtct gcgttagggt cttggtcaaa

9121 actgcatttc tgaaactaaa ctcagattgc tttcttttaa ggggtcagaa ctgattcaaa

9181 tctacatttt taaaagcctt agatgtgggg cttttcctat tcccagtctc cgctattggt

9241 ctttgtgaat ccacaggcaa tttggccaca tccttgactc tctcttatat taagaattaa

9301 acagctaagt tcatgcagag gaaatataac aaaggaggga ctttcctaca agatctttga g361 aaaatggaac atttgcataa gtcatattta gccagaactg ttgttttata ttttcctttc g421 tgaatacttt gttacacctc ctcccagcca accccccccc tccctgaccc caactagtca

9481 gagaccaaag ccttcacaat ggtttacact tgaaccttcc tggccccacc ctcatcatca

9541 cgcctgaata attacattca ctgactggtc tcccctgctt ccgtttatct ccactcctaa

9601 accctctgac accttaatct tcccagaata ccattgtgat cctgttccac tcttgctcaa

9661 gttttcccag aaactagagt acaaacttta taagctttag agttgaaagc cactctatct

9721 ctttttcatc cccaggtctc tgccaaggca gtataacctg tccaacatct ctaacttcaa

9781 tacctttgtc ttagatacta gactctcctc ctggtttcta attaaacctg atctaggatc

9841 taattttgcc tctgaattct gttgcccttt gccaagtgat ctcttcctcc tctgagccgc

9901 agcatctctg agcttgcaca cttagcatag ccatagcaca cacagcctta gcttgcagtt

9g61 cagggtgttt accttccctc cccttccaga tgctggatcc ccagggatag gaactctgcc

10021 cttatgtgtc catagcccct ggtagtatgt cttgcagtcg tacattttca gcaaatgttt

10081 aattggttaa ttgaagacaa ctgtcccatg ccttaagcct ctctttttgc taaacatgcc

10141 tgtgtccttt gtcattgaac aactattttg atctattttc ttcctgacat aggggtcagt

10201 tccgaggatg ctgaaatcaa gagacatagc ttattctctc aaaattgctt tcaagagtga

10261 ttttgttgtg aattgagaac tggctgccta cttttggact acccacttca gcaagagtgt

10321 ttgaaaccaa atctattcta agtaattttt tattcccttt tctctatggc attagacaca

10381 cagctctttt aaactacctt tcgttatcta ttaaacagac attcagtaac tctatagaca

10441 ctgtctagct atatgaactt agacaaacta atatctctga gcttcagttt cttaaaattt

10501 aaaatgagga caataccatc tatggccggg gattaaatgc tatgaggaat gtaaaccaga

10561 tgtcaggtac catctctcta aaatccagat aaaatgaatt aaaaatactg gccgcaaacc

10621 ctctctaaga gttctcaaaa ttctcagaga gcttaatttt catgctcacc atagcaccga

10681 ttttcttcta aatattttgt ttctaccaaa atattttgtc ccaattttgc cttttatggc

10741 tatttcttca tatccacttt cccaaactaa agaagcagcc ccttcacctt aaactcctcc

10801 ttcaaagcaa cctaaataca ggtctgggtt tgtattccta gtgggatgtt acagaggtta

10861 gtgtgatgca gaggaggagt catgctgttt aaatccatac tagtccccag aggccaggct

10921 gcttctgcca cccctacccc tcccgccaca gagctcttca gcttctcaca tttctagttc

10981 ttctctctct actttcatta ccttctctct tttttttttt cttctcatgt gctcacggga

11041 gcagagaaaa ttaactcctc taagttttct taacacagag tgccttaatt acatattact

11101 attgtttgag ttcctgccaa cactacgtct gtagggtcac acctgctata ttagaggctt

11161 atcaaaaaaa gatagctttc tcctaaaaag ggatttggat gcctactaag ataactggat

11221 gccaagataa gtttaaccta acaaacttta ttattattat tattattatt attagagata

11281 ggtacttatt ctgtcaccca gactgcagtg cagggatgca ataatagctc actgcagcct

11341 caaagtcctg agttcatgca atccttctgc ttcagctccc tgagtagcta ggactacagg

11401 catatgctac tctgcccagc tacttttaaa aaaataatta gggatggggt cttgttgtat

11461 tgcccaggct cgtctcaaac ttctggtttc aagcaatcct cctgcctttt acctccctaa

11521 ttgttggagt tacaggcatg agccacagca ctcaaccaag atttaaaaac ttttaaaaga

11581 aatcacatta cttactgtta tcatcattat ggttactacc agtgttaaaa caattggtat

11641 tgaaaacacc actaccagat caagcttcaa accaagatgt caagtaaata ttattgtcag

11701 acctctgagc ccaagcctgc aggtatacac ccagatggcc tgaagcaagt gaagaatcac

11761 aaaagaactg aaaatggccg gttcctgcct taactgatga cattccacca ttgtgatttg

11821 ttcctgcccc accttgactg agggattaac cttgtgaaat tccttcccct ggctcagaag

11881 ctccccgact gagtaccttg tgacccccac ccctgcccac aagtgaaaaa ccccctttga

11941 ctgtaatttt ccactaccca cccaaatcct ataaaacagc ctcaccccta tctcccttcg EPI-109 975

12001 ctgactctct tttcagactc aacctgcctg cacctaggtg attcaaaagc tttattgctc 12061 acacaaagcc tgtttggtgg tctcttcaca cagaccatgt gacatttggt gccgtaactc 12121 agatcgggga acctcccttg ggagatcagt cccctgtcat cctgctcttt gctccatgag 12181 aaagatccac ctatgacctc tggtcctcag accaaccagc ccaaggaaca tctcaccaat 12241 tttaaattgg gtaagtggcc tctttttact ctcttctcca gcctctctca ctatccctca 12301 acatctttct cctttcaatc ttggcaccac gcttcaatct ctcccttccc ttaatttcag 12361 ttcctttctt tttctggtag agacagagga aacgtgttct atctgtgaac ccaaaactcc 12421 agcactggtc atggacttgg aaagacagtc ttcccttgat gtttaatcac tgcagggatg 12481 cctgcctgat tattcaccca catttcagag ctgtctgatc actgcaggga cgcctgcctg 12541 gatccttcac cttagtggca agtaccactt tgcctgggtg gcaagcacca cctctcctgg 12601 ggggcaagca ccacctctcc tggggggcaa gtacccccca accccttctc tccatgtctc 12661 caccctctct tctctgggct tgcctccttc actatgggcc accttccacc ctccattcct 12721 cccttttctc ccttagcctg tgttctcaag aacttaaaac ctcttcaact cacgtctgac 12781 ctaaaaccta aatgccttac tttcttctgc aataccgctt gaccccaata caaactcaac 12841 aatggttcca aatagcctga aaacggcact ttcaatttct ccatcccaca agatctaaat 12901 aattcttgtc gtaaaatgga caaatggtct gaggtgcctg acatctgggc attcttttac 12961 acgtcggtcc ctccctagtc tctgttccca atgcaactca tcccaaatcc tccttctttc 13021 cctcctgcct gtcccctcag tcccaacccc aagtgtcgct gagtctttcc aatcttcctt 13081 ttctactgac ccatctgacc tctcccctct tccccagact gctcctcctc aggtcgctcc 13141 ccgccaggct gaatcaggct ccaattcttc ctcagcgtcc gctcctccac cctataatcc 13201 ttctatcacc tcccctcctc acacctggtc cagcttacag tttcattctg tgactagccc 13261 tcccccacct gcccaacaat ttcctcttaa agaggtggct ggagctaaag gcatagtcaa 13321 ggttaatgct cctttttctt tatccaacct ctcccatctc agttagtatt taggcttttt 13381 ttcatcaaat atgaatacct agcccactcc atggctcatt tggcagcaac tcctagacat 13441 tttacagcct tggacccaga ggggccagaa ggtcatctta ttctcaatat gcattttatt 13501 acccaatcca ctcccaacat tagaaaaagc tccaaaagtt agactccggc cctcaaaccc 13561 cacaacagga cttaattaac cttgccttca aagcgtacaa taatagagta gaggcagcca 13621 agtagcaaca tatttctgag ttgcaattcc ttgcctccac tgtgagagaa accccagcca 13681 catctccagt acacaagaac ttcaaaatgc ctaagccaca gtggtcaagc attcctacag 13741 gacctcctcc atcaggatct tgcttcaagt gccagaaatc tggccactgg gccaaggaat 13801 gccctcagcc tgggattcct cctaagccat gttccatctg tgtgggaccc cactggaaat 13861 cggactgtcc aacttgccca gcacccactc ccagagcccc tggaactctg gcccaaggct 13921 ctctgactga ctccttccca gatcttcttg gcttagtggc tgaagactga tgctgcctga 13981 tcgcctcaga agcctcctgg accatcacag atgcttttgg taactcttac agtggagggt 14041 aagtccgtcc ccttcttaat caatgcagag gctacccact ccacattacc ttctcttcaa 14101 ggtcctgttt cccttgtctt cataaatgtt gtgggtattg atggccaggc ttctaaaccc 14161 cttaaaactc cccaactctg gtgccgattt aaacaacatt cttttataca cttcttttta 14221 gttatcccca cctgcccagt tcccttatta ggctgagaca ttttaaccaa attatttgct 14281 tccctgacta ttcctggact acagccacat ctcattgctg cccttcttcc caacccaaaa 14341 gtggcaactc ctttgccact tcctctcata tccccctacc ttaacccaca ggtatgggac 14401 acctctactc cctccctggc aacaaatcac accctcatta ctatcccatt aaaacctaat 14461 cacccttacc tgggtcaacg ccagtatccc atcccacaac aggctttaaa gggattaaag 14521 cctgttatca cttgcctgtt acaacatgtc cttttaaagc ctgtaaactc tccttacaat 14581 tcccccattt tacctgtcca aaaactggac atgccttaca ggttagttca ggatctgtgc 14641 cttatcaacc aaattgtctt gcctatccac gccatggtgc caaacccata tactctccta 14701 tcctcaatac ctccctccaa aacccctcca taacccttat tctgttctgg atctcaaaac 14761 atgctttctt tactattcat ttgcaccctt catcccagcc tctcttcact ttcacttgga 14821 ctgaccctga cacccatcag cctcagcaac ttacctgggc tgtactgccg caaggcttca 14881 tggacagccc ccattacctc agtcaaccca aatttcttct tcatccatta cctatccagg 14941 catagttctt catgaaaaca cacgtgctct ccctgctgat catgtccagc taatctcccc 15001 aaccccagga ctggcaaatt gactttactc acatgcccca aatcaggaca ctaaagtacc 15061 tcttggtctg ggtagacact ttcactggat aggtagatgc ctttcccaca gggcctaaga 15121 aggccaccgt ggtcatttct tcccttctgt cagacataat tccttggttt ggccttccca 15181 cctctataca gtctgataat ggacaagcct ttactagtca aagcacgcaa gcagtttctc 15241 aggctcttgg tattcagtga aaccttcata ccccttaccg tcctcaatcc ttaggaaagg 15301 tagaactgat taatggtctt ttaaaaacac acctcaccaa gctcagcctc caacttaaaa 15361 aggactggac agtactttta ccacttgcca ttctcagaat tcgggcctgt cctcgaaatg 15421 ctacaaggta cagcccattt aagattctgt atggacgctc ctttttatta ggccccagtc 15481 tcattccaga caccagccca acttgaactg tgccccaaaa acttgtcatc cctacaatct 15541 tctgtctagt catactccta ttcaccattc tcaactactt gtaaatgccc tgcccttttt 15601 tacagtgctg atttatactt ttcctccaaa ccatcataac tgatatctcc tggttttacc 15661 tcaaaccgcc acccttaagt ctctcttaaa gtggatagaa gatcttcagt gacaaggtac 15721 actccaatac tttcacccta ataaagccct attctttact tttatattca ctcttattct 15781 tgttcccatt cttatgccac tctctacctc tccccagcta tctccaccac actatcaatc 15841 tcactcactc tctcctagcc atttctaatc cttctttaac aaacaattgc tggctttaca 15901 atttctcttt cctccaaaat caccgagtcc tcaatttact cactgctaaa aaaggggact 15961 ctgcatattt ttaaatgaag agtgttgttt ttacctaaat caatctggcc tggtatatga 16021 caacataaaa aaaactcaag gatagagcca aaaaccttgc caaccaagca agtaattatg 16081 ctgaaccccc ttgggcactc taattagatg tcctgggttc tcccgattct taatccttta 16141 atacctgttt ttctccttct cttatgcaga ccttgtgtct tccatttagt ttctcaattc 16201 atacaaaacc gtatccaggc catcaccaat cattctatac gacaaatgtt ttaagggagg 16261 agaccacccc tcatattgtc ttatgcccaa tttctgcctc caaagaaaga agtaaaaatg 16321 aaaaggcaga aatgaaatcc acaggcagac agcctgatgc cacaccctgg gcctggtggt 16381 taagatcaac ccctgaccta atcagttatg ttatctatag attacagaca ttgtatggaa 16441 aagcactgtg aaaatccctg tcttgttctg ttcctctaat taccagtaca cgcagcccct EPI-109 976

16501 agtcatgtac cccctgcttg ctccccctgc ttgctcaatc agtcatgacc ctctcacgca 16561 gaccccctta gagttgtaag cccttaagag gaaaaggaat tgttcactcg gagagctcgg 16621 tttttgagac atgagtcttg ccaatgctcc cagctgaata aagcccttcc ttctttaact 16681 cagtgtctga ggggttttgt ctgtgtcttg tcctgctaca gtttcatcta acaaccccat 16741 aatatcaccc cttaccacaa aatcttcctt cagcttaatc tctcccactc taggttctca 16801 cgccacccct aatcctgctc gaagcagccc tgagaaacat cgcccgttat ctctccacac 16861 cacccccaaa aattttcact gccccaacac tttaccacta tttcgtttta tttttcttat 16921 taatataaga agatagaaat gtcaggcctc tgagcccaag cctgcacgta tacatccaca 16981 tggcctgaag caagtgaaga atcacaaaag aagtgaaaat ggctggttcc tgccttaact 17041 gatgatattc caccattgtg atttgttcct gcgccacctt gactgaggga ttaaccttgt 17101 gaaattcctt cccctggctc agaagctccc ccactgagca ccttgtgacc cccaccccta 17161 cccacaagtg aaaaaccccc tttgactgta attttccact acccacccaa atcctataaa 17221 acagccccac cccatctccc tttgctgact ctatttttgg actcagccca cctgcaccca 17281 ggtgattcaa aagcttcatt gctcacacaa agcctgtttg gtggtctctt cacaccgaca 17341 cgcgtgataa ttattatatt acttttaact aaaacccttt cagagtctcg cagggaaggc 17401 tgtatatatc tcataaaatg ttggggccca ctggatcaga caaggccaca aaggccaaag 17461 ggaagtaaag atctcattat ttctcctaat aatttccctg tcctttgtca taaatggtgg 17521 gtaggctgtt atggtgatgg cagattttct ttccataaaa tgtccataat aggacatttg 17581 aacagaaggg aaaaatcaaa ttgctgaagt tgaaagaggg caatgcaaag aactttggag 17641 aaagaactgt acagagaagt caactggcag atgggaggaa gtttaagggg aaaaatatag 17701 atgtctaaag aatacattta ttcattttcc acagtgcaat ttggacaaga agcctctttc 17761 ttgcttcttt ctattctcat taaatcatta gagctcaagc aatccttctg cctcagcttc 17821 ccgactagct aggactacag gtatgtgcta ctatgcccag ctaatttttt aaaaattaga 17881 ttttaatttg gtgaactatt tctgtaggaa actacaataa tacagcccag gcacattgat 17941 cttgggtgaa caaatcagaa ggaatgaata attctgtgtt cctgggactc tgacaatttc 18001 atgaacttgg tactctgagt aaagcatagg aggagttatt tcataaaatg tggagcacaa 18061 tcatgtgaca aagataatgg gatccccatt tcataaataa atctgaagtt cagagagagt 18121 aacaactggc cagggtcaca tcacggagac agaggcaggg ttcccactga tgcctctgac 18181 tccctgtccc aggcccttcc tcctcccgca agcagaagtg cagggggcag agctgaccct 18241 gtgcagtgaa aatctgaggg ctgagttcct attggaacac aagtgaaaga cttcctggct 18301 tctaatctca ggataaggac tcagagctcc atctgttcca gccttaggat aagaaccaga 18361 atcttacacc atgaaagcat gaaaggtaag atttgagtga ggaaaaaaaa aaaaaaagtc 18421 tgtgtttcag attcagttca caaagcagtt tcatacttaa ggtaccatca caataaccct 18481 gtggggtaag caaggcaaat ttcattcttg ttttatgggc ataggaagta agtctcaggg 18541 aggttaagac caaggtttct ggagaatttt atattatgaa tcttgattta tgggattact 18601 attatgtaat tcctaagatc atataggaat cctagagctt gaatatagaa ctttattttt 18661 aaatctatat acatcataat tacaaggagt agtgtccatt tgggttcctt ggccctgatg 18721 tgttagtgga ataaacattt ttgtcagggt tgccatgtgt gtctgtgcac gtgtgcactg 18781 tacacctcca ggggatgtac cctaaaccac atgaatgtga tttgcacatc caagatttac 18841 agtgtactat agggagaatc ttttgcaaca gcttttgcta taatacagaa tctgagatgt 18901 ctttgagaaa gaaaagtgta atcattacca aaaaattatt ctcataatgt gtgcaaattt 18961 gtatgaaatc tatattggcc atgggacaag gaggtatttc cagctagctt ctgaaagggc 19021 tctattctct cataagaatt cagctgttga cattaggtga tatctgccca ggtcatcaga 19081 tgccatagag aaagagggtt tgctgaaact tatatcagca gtgcactgta tgctctttct 19141 gatttatttg aacattcatt tattgagtgt caagtaatgc actagatact ccagggatct 19201 gacacaaact ctgccctgaa ggagcatgta atctcactgg ggagaaaaca aaacatatga 19261 taatttcaaa ataacaaact aggcaaacta gttaacactt aaaaagcagg ctttattcaa 19321 atgcaaaatt gcatgttaca gggtaacctt tcagtaagaa gccaggaaga ggagctcatc 19381 atgggttgga ttagtaaagg actagttata aaagaagtgg tggggttgag ggaggcctga 19441 gatgaaattt aaagaatatg tagaatctag gtaagtggat aaaaggtctg ggggcagggg 19501 aaaggagagc atttcattgt gaatcaagga atttctccac ctgttttaac tcttccatat 19561 gacatcaaag agatgtcact tgcagctagc atttcagtga tgttttctta ctaataatat 19621 cgtgataaaa gaaacattga ctataagaaa taggaatggg tctcataaaa ggaaacagca 19681 aaacccccaa actaaaaaac agcgcaggct atttctctct tctctccttt tgcttggcac 19741 tcatgagatg ctaggtgtgg aagtcagcca actgaaaaag agaggtggct gaagaaggtg 19801 gggaggctga agccagttaa ataggatggt ccaattcaca gacggcgagg ctacagtgca 19861 aataggactc tttcaacttg agcaggaccc cattacttca ctggagttag aaagaaagga 19921 gagcgtagac tttttgaact ttctataaga gtgtacctcc acagtataca gaagacgacg 19981 tgaaatttga tctgcaagaa aactgagtcc atattcacat atgtatcaaa tttgcacttc 20041 atttagaagt gtctgtcatc aagtacagca ctgaattgaa actgaaaaca agagtcaaga 20101 aagagcaaag tcagccatct ttatattcca catgaatcct ttccctttat ggtcttattt 20161 gtttctcctc agaaaagaca aaaagctgag ctgtataaac acctgtgggc tgggggttga 20221 gggataaatg aggggcgaaa tggaagctga aggaactgtt ggtcaggtag aaatcttccc 20281 agatgcactg aaggaaacac acttcatgtt tgacgtagga ggtgccacca cacaaaacgt 20341 ttcatggaag gatttaaagg atctcatgat ttttagtatt ccaagaattt tctttcacca 20401' agggcgattt aatatgggtc attcatactg aaagaaaaac aaaagataat aagagtttaa 20461 aaattgcaaa acttggagtg ttagtagtaa aggtaaatat tcattagaga tgagaagagg 20521 agcaaggaaa tgctttcagc tggaaatctc agacaagagg ccaggcttta ggaacctctg 20581 aagatgaaca aatgtaagca aaccctagta gcagcacttc tcagattttc atgtgcttac 20641 cactcagaga tggtgttaaa atgcagactc tgattcagta ggtctgagtg gagcctgaga 20701 ttctgcaccc ctaacaagct ctttagtgat gcttatgcca ctggcgcaca gaccccactt 20761 ggagaaattt ttgtggtgca tacggtcttt gtctccagat ctaatgagtc tgaaggacag 20821 tgtagattga ttttttaaat ttatgtttat tttaatttaa tttaatttaa tttatttatt 20881 tatttatttt tgagatggag tctcactctg ttgcccagtc cggagtgcag tggcacggag 20941 gcagctcatg caaccacggc ctcctgggtt caagcgattc ttccgcctca acttcctgag EPI-109 977

21001 tagctgggaa tacaggcacg tgccagcaca cccagctaat ttttgtattt ttagtagaga 21061 tggggtttca ccacattggc caagctaatc tcaaactcct gacctcatga tccacctgcc 21121 acggcctccg aaagtgctgg gattacaggc gtgagccacc gagcccagct gtagattgat 21181 tttgagcagt ggaaagtcaa ggaattagaa ggcatgctta aatggaaagt gaaattggag 21241 aaaatttaaa ctcatgaaat agtggtggtt ataaactcgt gataaattat atcctgggat 21301 ataatttaat gagatggtaa cacatttagt ttaaagaaat aagtgacact ttttttgtgt 21361 gacacaactg tcttattctt ggaaaggaca aggagagaat gaaatatggt atgtcttcac 21421 agcacctttc aaagggagaa ccagattctg aggagctggt ctcatgatga actgtcaggg 21481 taaaccacag ttcagcagct gcaaatgtgc ttgccaaaat agagacaaaa aaatgtttct 21541 gaaaacaaaa tttcacatat gccctcctct gaggttggca tcatatcttc ctgtgtatct 21601 tgggtgtagc ttctatcctg ccagaattta gacagtagaa accaaatgag gtgataaaca 21661 gagtcatttt gcagaagagt caaaataacc cagcaagaaa tgaaaccaca aatgcccaag 21721 gagtcattca ttcaccattc aaaagctaat agaaatgaac acaaactact atgaaaattc 21781 acccaagaac ttaaaaaaaa aaaaaaaggc tcatggtgtt tagtgtgata gtattcattt 21841 tacctttgac ttgttctaaa aacacaccat acttctaccc cacccttcct cagtgccgtc 21901 acacaatggt ttcagtgtga aaaaaaaaac cacgttactg gaaaaggagg gtgcctggga 21961 cttgccactc taagctggta gtcaagggtc ttgagttcta aaagcatacg cgttaagagc 22021 atgattcctg gatccaaatg agtatggatc tcagcattgc catttattgt gacctcaggc 22081 tattttattt ctctgtgcct gtttctttat cagtaatgaa gatgttcata gacccttctc 22141 ccacagactt aaaggcatat ttcatgattt aagacatgta aaccattcat aacagtatac 22201 aacatggaat taatatttga taaaggttta tgattattgt aactaactct gtcacttgct 22261 caaggcctat agaaaactta cttaattagt tcaactacaa aaagagtttg aatgtgatat 22321 ccaccaagat catattcaga cctagaattc tgtgattctt atgaattaat acagccttgg 22381 tcaataaatg agagctgggc aaataattct tctttgctag gcctttctag accatctggt 22441 gaagcattca agacttatgt tattggggcc agccttcctt tccaacttca actccacaac 22501 tcctcaataa gccatgggct caagaaagtt ctgctcagtg gcccctgaaa aatgctttca 22561 tagtctcact accataccac tgcttacaca atttccttcc tacagactgc cttcctttcc 22621 tgcttttctc catataccta aatcctatct attcttcata agcaaccttc tttataacat 22681 tttctataac caccaagcca aatgaccttt tccttcttaa atatagcacc cattggccat 22741 taccatgctc tgccttgtat ttttctgatt tttttctttc tatattcctg tcttaactcc 22801 ccagctaggt aataattttc ctgaaatcag ggaccaggct gactcctctt gctgtctcaa 22861 gaaagcttag cagtttccaa cacaaaaatg ttcaataaac aactattaat tgactgatta 22921 taaaaaatca gtgaaccatt aaacttaata tagcaatttg cttagcatgg taattagctt 22g81 tttgctaata ttcttccagc cagtctctcc tcctgtgcct caaggacatc ttaaaaaaaa 23041 aaaatctagt tgatctgctt ccatctagtg gcaattaaaa caggtggttc cggtagccag 23101 aaaacagctc tgggtagatt gtgccagaaa atactttcac tcagtaggtg cgagtttgaa 23161 agaaatcttc acatctgtgg gtttcctgcc acagacatag ggagaccagc ccagagaaag 23221 aagcctttcc tcactagact ccatttgcac tagtaaagag aagacagagt aattaaaaag 23281 aataaaaaga acctccactg atcgtacatc ctcatccagt tacccctgcc ccacttctcc 23341 ttcacagcca aacattttaa aagagatgac tgcttgttct gtctctactt tctcatcctc 23401 agtaatgctc aatgcttggc cgtctgacct ctgtcttgat gtctgcactg caaatagtct 23461 ccccactgac acccttgttg catccagggg atacttactg gttctcttgg caatgtttga 23521 aaccgttccc ctttctttgt ttccttggca ttcattaccc cacactcttt ctcctcttcc 23581 ttctccctgc ctggcaacat cttttcattt ctctttccct taggtgactt attagataat 23641 gatgttcctc tggctcccat actctctccc aggtcctctt ccattcttaa agcactcaca 23701 ccctccctgg atgatagtac ccactcctga gatggcagtt acctcctgaa atgtgaggga 23761 cccaaatcca cttctcctgc catagcctct gtgctttgga taggtccaat gagccacagt 23821 gaatgatgtg catacaccca aagctcagta caaaactgaa cccatgatct ttacctccaa 23881 aacctctcat tcttttatgt tcccttctca gaagtaaaca ggactaccat ccgccagttt 23941 ccaggtgaga aagatgataa tttgattctt ctctctcact tttagccaat taacagacac 24001 attcagttaa tatcacctcc tcttatttca tgaacccatt cttactacta gttccctaga 24061 caggcgccat cggttttaat ctaataactg caaatgcctc caaaacaagt ctctttgaat 24121 ccaggctcac ctgtctccca cacttgccat actgctctgc agggtgacct tataagatgc 24181 cagaggtaag gctactcact gtttaaaccc ctttagtgat atcccaaaag acctcaagat 24241 aaagcccata tcacatggct tatacattag tttatgatct ggcttctggt gcctcatttt 24301 tccccacttt ttcctttgca ttctaagcaa tggcccatac taagtttgtg attggtagga 24361 tggttgccca aaccagcatc caatcccttc agaaatcatc tcacttcatt tctagcattt 24421 taaaggaagc tcagttgtcc agctgggtac tgaatatgtc accaaagtcc tcctttcata 24481 gtttatttta cttaaactct ccttcctaaa attccagagc aagtcactaa accctagata 24541 ctgagaaata tttttccatc ttcatttctg ccaggtgggc catcaacttt cacatgtctg 24601 catctcctcc cactgtgcta tttctccagt agaagaaatt tgagcttcaa gaccaaactg 24661 aaaaatactt gcctccttgg ggaagctgta ggtagaattc atgctcccta tctttcccac 24721 atttctgaag gacaatgcct gttagagcaa ttgaatgcaa atagtcaatt gaataagcat 24781 ttattcattt ctcaataagt gcttgttcaa ttgaatattt cttaaataat atatttaaga 24841 acaagaagaa cacaccacaa tgtttttaac cctcagaaaa aattctgagg taatcagaaa 24901 aatctccctt tacataaact gcccttttct aatagggatt acttgttcgt tcattcattc 24961 attcagctcc actagcacca aaaagcacag ctctgaaagg aagctagtag atttatcacc 25021 ttatctggtc atttggatga ggaccccagg taaataaact actatggggt taatgtgtct 25081 agctagagca ggaagtaact taaggaagta gagaatgaat cagcagatgt ggaaactcct 25141 cgccactaat aaaacttacc ttctcttgga tttcttgcct gaaaatagaa aatagagaaa 25201 aggcattagc aaaaattaga caatttaaag tttttcaagt aagggagaag gaagactccc 25261 actctcaaaa ctgtcttttg aagtatatta ggtatttgtt aggtggaccc tatctgtgtc 25321 aaaggagatt tgaggaactg gcttaataaa cagtggtaga cactaataca gaacagacat 25381 gttgatgcag atgcctcctg aggttccatt ccattctccg tgctactcaa gaagacagaa 25441 ttgctaaatt gcctggtggc aagacccaat atgtccattc aagtgtttat cccttcccaa EPI-109 978

25501 tctgccatct catcctacct gcagattctt cccttgaggg acagctgcta atactgtaaa 25561 actatgtgcc attacagctc acagcatcat ctctatgaga atccacaaga gaatttcact 25621 ttggtcttgt tggtaggaat tgtgcagcct catctgagta actaatgtgt ttttatctta 25681 caaacacaag gaatatcaca tggttctcct ttgactggct gtaaggaaac tcagagctag 25741 atctgagacc ctctcctacc aagtatataa aactttgtga catacatttt tgtgccataa 25801 cttcaacctt ggttccaaat gatttttgta ccctaagttt aaatttggct ttcttttttt 25861 tttttttgta ctcaataaaa catcaagctc atttattatt gcgaagagcg aaacaacaaa 25g21 gcttccacag cgtggaaggg gacccgagtg ggttgcccaa attggcttct ttttcttact 25g81 ttttaattaa ttttaatttg ctatactgaa cacattttgt actgttctca cattcttttt 26041 gaaaaaagca gaatataaat aagtagataa cttaaaaaaa actctttgag cagaaagaat 26101 catttgggag gcaatatatt tcagtggctg taaagtggca ttctagaatc atcctaccca 26161 ggtgaaagcc ctattttgcc acctgtagtg tagtgtgtat ttgaacagct actttctttt 26221 ctaaactaca atttcttcat ctgttaaaga ggcataataa ttgtatcatc ctcattgggt 26281 tgataaaata aaatatttcc aagtatttag ttcaggtcct agcacgtaga cagtgttgca 26341 ttactgtttt aatcctttaa agtattaaag actactattt gaaatctttt cttctaaaat 26401 tcagcctgct gatgaccaag tgcacttgag cagggggaat caaatctgaa ttaatttcag 26461 attctggtta gcttcacata aatatttttt ttagggatga tgaacctaac agcaatagat 26521 gagtaagaat ctgttcctac tgagagagtt tcattttgaa gaaaaaggaa ctaagggggc 26581 atgtgttcag tttcatgccc tggtctaacc ctgtgtgttg gttctggtgg gaaattcttc 26641 caaccgagga aaaaaccagt tcacaaatct gaagaccagt gattttagaa gatgtatctg 26701 gactggagtc taatctctga ctctgggtcc tgctgatatg gtatttttga gatttggcct 26761 aaaacatcat tgccctggtt tccttattta ccaaacaggg ccaatggtag tgactaatca 26821 gaaaatgata atgcctggtg cacaaaatgt gtctagatga gcccatgcac aaggacacat 26881 gtttctggaa ctgttcctta ttcctttcct aaaagaaagg agggaaagtc tccatactaa 26941 gactactagg gcaggggaca aagtgctaga gtcagaagat tcatctgagg acagaagaat 27001 aggggtgaag gctctagtca cttcattggc taccatgctc taaatagtta cctgtgccct 27061 ttttctaact attagaaccc aaaaagccta taaattctct ctctctctct ctctctctct 27121 gtgtatatat atacatatac acacacacat agacacacac acacacctaa acacacacat 27181 agagatttat gactttttac ttttatcctt gtaaatgcca ttaactatat tttgtcttag 27241 atttagcctg ggaatgtagc cattatttct accattgcct ccataggaaa aatactcttc 27301 atgttttaaa ggaccaacct acaactaaaa tctttggaaa gcagaatcat ttgtaagttg 27361 gtgaaaatgg aagatgttgt tttataaatg aagacttttt tttttttttt ttttgagaca 27421 gggcctcact ctgttgtgga gtgcagtggt gctgtcatgg cttactgcag ccttgacctc 27481 ctgggttcaa gtgatcctcc cacctcagtc tcctgggtag ctgggactac atgtgcatgc 27541 taccatgcct gactaatttt ttgtattttt gtagagatgt ggtttcgcca tgttgcccag 27601 gctggtcttg aactcgtggg ctcaagtaat cctcctgcct cagcctccaa aagtgctggg 27661 attagaggtg acagccaagg tgcctggccc acagatgaag actatttaat gttatcttaa 27721 agatacccta agcttcctac caagccagtg atcttttggg gcttctgttt tctttgttgg 27781 cataactgta actagcctaa ctgcccgtta tctgtttcct gtttgcccca cactgattcc 27841 cacagcagtt ttcaagttat cggtttgaga tcttgtacag aaatgactcc aaggtaaaaa 27901 atttaaaaac aacccctcta atttttttac ccttgcttat aaaacagcct tagccagcta 27961 acccctcact acatgcaaat gagtttgatt ctattctttt gattctacaa acacttatta 28021 aaagatttta gaattcggaa ataaatagct tccttattaa ggtgacttac agccccaaag 28081 tccttaaaat tatttagaca atagccacct tatcccaggg ggcagtgtgt aataacccac 28141 cctgttctct atccgtcagt tctgccatca tcgcccaagg taggaagaaa gacaggacaa 28201 ccggggtcaa gatttgaagt ctcaatggaa agaataatca gtggttggag aaaactgtca 28261 ttcttctttt gccttaatgc agtacttgat acttatactt agtactgtat agtacttagt 28321 actgtataat actataagat agtgagattc aatcagcaca gaatttctaa tagcaagggc 28381 agagacattt taactgctca gtgctctcag gttatacata gctaatgaag ttcttgcata 28441 tcaacaatcc ccacccccct cacacacttt gtctttctgg attggttaga aaacttacct 28501 agcgcccact attctcaaat ttaaatgaaa gataagatca gagtggcacg caattaggga 28561 ctgataaata atatttttgt aattgccagt gtaaatggac agggggcaac ctttacatac 28621 catattcagt gaacagaata cgtactaact aatttgatgg aaggaaaatt aaaatgacaa 28681 tcaactgagc ccacagaaag gcaacacaga gcagttggtt agcaattgtt tcgagatcat 28741 ccctgaactt gaaacaggta tatctttttt tttttttttt ttgagacaga gtctcactct 28801 gtcaccaggc tggagtgcaa tggtgcggtc tcagctcact gcaacctccg cctcccgggt 28861 tcaagtgatt cttctgtctc agcctcccga gtagctggga ttacaggtgc ccgccaccac 28921 gcctggctaa tttttgtatt tttagtagag acagggtttc accatgttgg ccaggctggt 28981 cttgaactgc tgagctcatg atccgcccgc ctcggcctcc caaagtgctg ggattacagg 29041 catgagccac cacacctggc caaaacaggt atatcttaaa agctgcccaa tgtccatgaa 29101 tgttacagcc ttgaatggtt cttccaggtg agtttggcca aatgtggcac catacaccca 29161 aggcctgctg caggctagtg ggttgctcac actttaaagc tgagacacac tcatgcctta 29221 aggtaaaggg agtgataatc tgggcagcag atgttaactt ctcaaggcag tcctccttct 29281 cttttcctct ccagtgacgg atggttggaa agcatatatg gtgcatttgg ttagagctgt 29341 ggccttggtg aatagatact tgggagaata catgggaatt tctcccaggg ttaatgcaat 29401 gcccatgtgt tgggaaccag gtgactcttg aagaggtcag gtatttggga gcagtgcctt 29461 gaaaccttag tggacattag acccacttcc tagtggaatt gtagcattga aatccaaggc 29521 atgtaggctc ttagaggaca gagatagtgt gtcatttttt cagaattaat taagagcagg 29581 ccaggcgtgg tggctcacac ctgtaatcca agccctttgg gaggccaagg caggcagatc 29641 acgaggtcag gagatcgaga ccactctggc taacacagtg aaaccccgtg tctactaaaa 29701 atacaaaaaa ttagctgggc atggtggcac gctcctgtag tcccagctac ttgggaggct 29761 gaggtgggag aatagcttga acccagaagg cggaggttgc agtgagctga aattgcacca 2g821 ctgcactcta gcctggtgac agagtgaggc tctgtctcaa aaaaaaaaaa gtattaaaga 2g881 attacataag agcaaagaac cattagaata tctcacttag ttgttatcag cctagcaagc 29941 tgccttgaag gtaatagaca tttttaaaag tttatcagat gaaaagcgaa aatcagccaa EPI-109 979

30001 cctgttttaa tgaaggtgtg tcctgggctg atttacatgt ctccagggac tgatggctct 30061 agaatgtaaa gcttggcatc ctgcttgtgt tgaatctatc acatttaatt tcctgtgggt 30121 ttcttttttt tttctttttc actttaaagt tgtgttcttt tcatgtgaag ttaaactcac 30181 ataccttttt ttaatctcct tgccagccaa atgataaatg ccaacccaga gaatgcagta 30241 accatgactg ccactggaat gaagaggggg ttataatcac cctccttaat cattgagaaa 30301 cttttgtcca attctgaaag agaaatcagt aaggcacata gcatgagacc accagcatta 30361 tttccttagt ctatctcatg atatttgact tttttcctcc ttacatctcc cagtagtagc 30421 ccatttgatg ccatttgaca gatgaggaaa ctggcatggg aaggcccctg atgagtctac 30481 agcataggca aagactggac cagccttgct agtctaatgc ctacagaatc tcaatgccca 30541 gatttgtggt tcatagagtt cctgaaaatg cacctaaaaa tgttggcaag aatggtcatc 30601 gttgtattta gctccatgga cttgttcaat gactggaact ctgaaacaca gagaagagct 30661 aaaagcctaa tacaacttca ggaaaaataa aagccaatga tctgaactgg ataattcacc 30721 agtcaaagga aatcattaat gcttttactt taaagcagtt gtgcaaaaat aagcacttga 30781 tttttacatg ccaaggacct gcactaattt ctttccaatg cagtagttac cacttccctc 30841 tacttccttc acgaataagt aaaagggcat gtttagagat actcttgtaa gtgtaaacta 30901 agttcatttg ggagcctcta tttgaaaata ctggtataaa aaaaaatctg tctcctgata 30961 ctaacatttg aaggaatcta cttttttaca tattggcaga gggtctgatt ctatccttag 31021 ttcttcccat tactttgatg aaccttttca aggtgatttg atccccacac ccaaatatat 31081 gattgagaga aggctcaagt tcccaggagc tccagacaga aggtacctgt tggcttgatg 31141 aagatgagga ggaaatgaac actagctagg ccttaaaggg aaatgtctct gataggccta 31201 atacacagtc ctctgctaaa ggcctccctg cctctctctg ctcatccact ctactccctg 31261 gccctgggca cgcagcacac agagatcagc atttctgaca gcttctgtag atcctaccat 31321 ttaaagactt ttgtcatcca tgcagatagt ctcaggagca gacacaggta gctattcttt 31381 cacatgctag cttaacatgc atttgcttta gcacctattg ccaggcactg tgtcaggtgg 31441 agggtataca aagatgaaca agacatgatt cttctcatat acagatagat tttggaggca 31501 ttagcttagt gatgattcag gagtatccat tatttgggga agtaggtggt cattagtgac 31561 cttttacagg catttcaatg ggctaacaga gatgttagat tgtagtggaa tagaagaatg 31621 ggtaaaaagt aaatcagtga gttcagattt taggagttaa gatggcaaga ggtgagaaca 31681 aaaaaaggaa atgattgtca ttaaaggagg aggaaagacc agccaaagat tttacagtga 31741 gttaagcata caaatttatt tctaggccac atattcttag caaaacaaca tgtaaatgtt 31801 tatgtatgtc tttcctcata tctgctcatc catcagctcc atcgttaaga tttcagtttt 31861 ccaggacaaa cttactcact ttgacatatt ggactaggat ttgaccagat tccagatgat 31921 tcacaaatgg ttttcttctt cccaattaac tcagttcctt ctgagcagat gaaggtacat 31981 gcagaggtaa agctgaagct ggccagggga tggctacagt tcatgatccc caaatctggt 32041 gctgatagag gctcacactg aatcacttca atgaaaaaga aaaaaaaaaa aaagacaaaa 32101 cagtatttct gagtagagac cctcccttga gcaaaggatt tttagccaaa gctgcctgac 32161 tacattactt gtgatattgc ttccaggctt tattttcttg agaatgatgg tgggtggtga 32221 atgagagatg aaggcaagga agcattgaaa gctgtgggga gaggagtagc tactccaggc 32281 tgctgcccta gctaaggtga ccctcccctt ctgctggaag taccatgcca tatggcctct 32341 gcatcaaggg ctcttatggg atattctcag agaatctctg ccgtttcatc tgttctgata 32401 tctacccaag cattttgaaa aacatcccaa ttcactgaag caagtccaac ttccgtaaat 32461 tccagtaggt gggttgacag ttttataatt tcaataaggg attttgatag cacttctaag 32521 aattaaacta cttaaactaa tgcatcagga gcatacttgt agaaaagtta accaaaactt 32581 cgtaagttca gatgacattg gttttctccc atatggagat aaggttggca gttaaaaatg 32641 aaaaaaaaaa aaaaacctac cttatttcaa acttgaaaag atcaagagat tgtgtttttg 32701 tttttcagtt gttattctcc taaaagttta tgcatgagga aaagtaaaag tgattttaag 32761 aataagccaa ataaaacaac caagaaagac ctccactacc ctgggaagga aactggttgg 32821 tattaagtag gacaccacat aaaacaggtg ttattgagag gagaagaacc aaaatgtaac 32881 tgaggttcaa caagacatta tttatgcaat ggcaatgaga aaaataaaaa acacagtata 32941 accatgctgt attgctataa gtcatgttac acactgggag atggcttcag gggtatttgg 33001 tttttacttt ttgtttggga ggtttttcaa aaaaatttag ttagaataag tcctttgaga 33061 aacatcacag taggttaaac aaagttaggt taaattaggc tcctaagttt gacttctcag 33121 caaacttcta ctgaatgttc tgactgtaag cccaggattg catgacaaaa cctctagtct 33181 gaagttactc accttgacag gttggttctg gagatgacca gtttccaaat ggtccacagg 33241 tggtttcttc aatcccagtt aagtttgttc cttcagagca gctgaaggca cactgtgagc 33301 tgaagctgaa gtttcccaaa gggtgagtac agtccatggt acccagctct ggggcctcca 33361 aaggctcaca ctgaatcact tcaataggga aagaaacagt atggggaaga gttaagagga 33421 actgacgcct ggatttgaat cctagccctg ccacttgata accatgtgcc tttaaacaag 33481 gttacttgaa ccctccaact tcagtttctt catctatata agaggaataa tgaaattgtg 33541 ttatctttat caaattgata tggaaactaa atgtaattca attagcataa gtcaaggacc 33601 ttagaacaaa gcctgactca tcagaaattc taagtaaaca ttagctagtc ttcatattat 33661 tatcttcagc attatctgta gtgagaatcc ttaaagccaa ataggtgtaa ctgggaatga 33721 ccagcttagt cgggaaataa ctatcacatc agagcccctg agtctactag agtattggga 33781 gcaagatgtt cagagaaaga gtgggtctcc ataataagcc ttctttgcaa ggagagaata 33841 taaaagtcta ggaagcattt tgacctcaat tctgtcttct attctagctc agttccagaa 33901 ttttaactct tttgattttg acaaccctct ccagaaactg tatctatttc cctgttctga 33961 ttggtggtac aataggtaaa tttaagactt ggaaatcaaa gttttcacat tttagaccct 34021 gccatgccat ttagtaaaca gtacaacttt catgtcttat tcctcatctg tcaaatttaa 34081 gccattattg ctaccttgct ctagagactt caaggaagaa tggactcaag gaatcagaag 34141 aatttttgta tttggaaact atatgagatg agattaggga gaaacatggg aactaagaga 34201 aaatgttatc ttttttcatt gatttaaaga gtatctatta tatatcaagc attactctgg 34261 ggcttgaaga gcttagattt caccctgtag gacaaaatgg taggtagaaa ttaatgggtg 34321 gattgtcatg tatgtgtgat gtgttttaat tgcttttaat tgatcagtct ccctgtagta 34381 tgaataatgt atttgagggg agctaattta aaattgtgga actcatctaa taaactattg 34441 caagaatcta gaagaaagat aatgacggca atggtagtag agttgacaag tggaagacaa EPI-109 980

34501 attagaaaaa cactaagttg taaaaattgg tagaatgtta ccctgcataa atgttggggg 34561 agttaagaga gtctcatacc agggtgccca tgtaaatggt gattccacat actgagataa 34621 gaaatacgaa gagaaaagct gactgggaac aattggtttt atagtctttt aaacatccca 34681 aaggacatcc ttagcatatt tgagttcaga gctggagata ggcttatcag tccaaagatc 34741 acatagattt gtgagtccgc aaaagtcagt aagtttgacc aaaggataca tgtagattag 34801 agtcagaaga gcaatataca aaagacaaaa gctgagaaat tatagtagtt tatggtcctg 34861 gataagtgct catgaaggat ctcaggagaa atgatcacag gtagaaagaa tgagaaaaga 34921 gtgatatgag agaaaccaag acaaagaaaa gtaaaatgtt aaaaatgagt gaaataggca 34981 taccaataat taaaaatgag taaaataggc ataccaataa cataagggtt aaaaaataga 35041 gttcaaaaat ggggtgaggg taaagtatta ggaaggagtc atggcccagg gatcaagtga 35101 aatgagttag atctatagat ctatttcagt tggttgacat ttaaatgtat tttggtttta 35161 attctttatt gtttacaaac attgcttttt taaaaaatta aattgtccaa ttcaattcag 35221 gctcacaagc aagtgcctca tatatacagg cattttgtgg atcccaaaga tgcaatgata 35281 aataggacac ttactgatct caagaagttt tcagtaccag aggagacgga caagtgaaca 35341 gatgacttca acataagtgg gagaaatgag gaagaaatat gtggagctat cagaactaag 35401 aaagcttcct agaagaaact gtctttgaac aatgtcttaa agatgacatg ttttttggcc 35461 atgtgcaaaa tgagagagaa ggccaccagc aaagtcagtg tgctacagag cacatgtgtt 35521 aagtgtggag aactgcaaga aggaaaggaa ctactagaag gaaaaagcaa gatactttct 35581 gggtaactca gcctcctaat gataaatggc atagtttctt ccagacctta gagttctaat 35641 taatctaaca agctcattag atcgtgagct tcttgagagc gggaatctac catgctaatt 35701 ccttatggta accctgacag cttttatccc aacactgtgc ttcttgtggt actcaaaaag 35761 acttgttgag aagtgagtcg aaacttcatg ctgacttatg aaatctttac ggaaaggtaa 35821 caatattgtg aaagcagagc tttctgatca aaacttccca tttctcagag tggctagtat 35881 cattttgttc caaccagctt catgataagc tataatgatt cctgtgactt tacctaagaa 35941 gaagcaaaga aaggaaagag acttaccaaa ctgacactgg ggcccatagt accccacatc 36001 acagttgcag gtgtaattat tgatgatttc tacacattct ccatggccac tgcatgacca 36061 gggctggcaa gaagctttaa ggaggtcaga aaaaaaatat tttaatgtga ttacatttta 36121 gtactcaaag tcatttcttt agacatagat aaccttttgt ctgagatgat ttaaataatc 36181 aggaaaggtt tatttgtaaa ttcatagcat aaaaatcata tgctaaaatt tttacgtata 36241 aaatacacta agcatatagt cataggcatt tatttgcttt tggaatgaaa ttaccaatac 36301 taatattctg taacacttat aggaaactta gtggcatacc ttgaaactct tgaaattact 36361 tgtttttaat gagtgagaag gttaaatgat gacctgacet caatcatttc tgcatgcaat 36421 tatttcttgg caatcccttt ctttatagaa atcaaagatt aaaaagtcca aatttgctaa 36481 aacggtagag tccaatttat aagagaccaa attaactatg gttcattatt aaaacatcac 36541 ttggaaaatg ctggctgttt tggaattgta gaagatttta cagaaatatt catacaccaa 36601 agatagtgca atttttatat aaaattatat aaggttagac caagaaggaa gcacgcagca 36661 ccacactctc tacttcacaa tgtgaaaact gaggtgatgt gagcctaagt ttccaactgg 36721 ccccagctgt cagcttctcc tcccctgcct tattatcaaa ggcactgatt gtctagctct 36781 tcctctgtac ttcctacgta gatctatcat tttgatgtaa cttgatttag gggtatagct 36841 tttgtgcaca gggacaaatc ttacacacca aaaattctta ggagtgacac gatgcaagat 36901 tatatagagg gctagatgta ttttagaatg aaccagaagc tgttctcatc cccccacctt 36g61 tccatggggt aaatctgagt attctcttaa ccgtggccct tcctgagtct gaggcagcat 37021 agccgtcttg tcactcccta cctgtgtaac agagggctgc ctttagtttg tggcaggcgt 37081 catcgttcca tttgcctgca tctttgtttc tcttgatata gatctccacg cagtcctcct 37141 tgttcttctt gttgttgggc tcaccatctc cccagttctc tgcttcttca gtaagagatt 37201 tgttggttcc cacccacgtc catattcctc ctatcttccg gattcctatc cagtagtaag 37261 aacgactgaa aggcagagtc ttctccagat actcaatttc cgccttgttt tgtatggcaa 37321 ctaaatctgt gtaattgtct cggcagaatc ttctagccct ttgccagttc atgggttttt 37381 cagaataatg gtaagtccag cagtcggttc catgatgtgc caggaaatct gcaagacatc 37441 agtgtgacct atgcagactt acataatgtt acagctaaaa agaacctagc actactccag 37501 gctgagctag acacttagag atgaggaaac agagcctaag agtgtatgtg accatctcag 37561 gatcacagaa tagttgtttg cagatttgaa gtagaaccta gaccttctgg cttgaatata 37621 agatgctttt atctaaggtt ctatttgaaa caaatttagt ggttttctag gtttattttc 37681 ttattaattt ttttctcaaa attatttcag gtgaaattta accaacatat tttagacatt 37741 catatttctt tttctttgta gctgttaatg atttacaact aattaccgtg taatatcata 37801 taactataca atttacgtat actttttaat cctggaatca tttcttgaag gccaacacat 37861 atgtacctat gggagaagca taataaggac aggaagaaca gtgacatact tttaagtaac 37921 ctcttttaca taaaaaacat tttattttac cataggaaga actgcttctg gaaaagccca 37981 atataccact caactcttat atatctaact gtataatttt taaaaagaac aatttacaaa 38041 gccaaatggt ataggattat gaaattcatt agatcatgtt ctatacacaa agagactcaa 38101 ctgatgatgt ttaataaaca tatggaccca tcaaatatga gggctttgaa gatatctaat 38161 taaacacata attacacaat gacttcataa taatatatgg cattctaagc atggtatgat 38221 ctacatgaat cactatttaa tacagtaaag aaacagatat aattgatggt aaagagcatc 38281 ataaaataaa cattttgaac agagttttga atgagcattc cactagaatg caagttctaa 38341 gagggaaaaa actgttgtgt ccactgctgt atccttagtg cctagcataa atttcacaca 38401 ttgtagggac tcagaaaata cctgttgtat gaaaagagea ctaagtttct atgtgacaca 38461 gtgcagacat ggcataagga atgtgtgaac gggagagtta gcatgtttgc ttggctagag 38521 ctgaaaatcc aggctaggga gaaagaagac attagtttac ttaggaaatg aaaaaccaag 38581 ttcaaagcta ttgctggaga gtcttcaaga atcagatata aaatttgtca caacaatggg 38641 agaaggacca aaaaatgata aacccccgtc ccttaataag ctcgtattgt aattgtagaa 38701 atgacattaa tgtacactga actatgaata aaaaatagaa aatgaggtgc taaatatttg 38761 gtacagattg taagtacctt aacagagatt tcttaattaa cattattcct ttataattga 38821 gggattttgt ggggttattg ggatttgaac tctacagcat gggctattat aggttaaaaa 38881 tagtgttcag gagtttctgg ggaagaacta aaggtaagaa gaaaagagat gtttacagaa 38941 gggatagaat taacagctct gtgaaataat tttcccttag actatgtata actagtggat EPI-109 981

3 goo ι atttaagaaa aatgaatata agtaaaatag acttagcgat atataaatat cataacatac

39061 cacaacagag cattgtccac ccccacaact tgaagatgtt ccataagtcc ctctgggtgc 39121 tctgacattt ccatggaaat atctgcaaat gaaatacaaa attatattta gatgtatact 39181 cttaaaccac acatttatag cctttgaggt ggtgcttaca actttcttaa taatcagaat 39241 aaaacacata tgtctactaa ccctgtctga ggtaacaggt ttctcagaca tagatgaaaa 39301 attacttcaa atttacatca gaactgatgc acagttttgt tttgttctat tttattttta 39361 cgctttagtc tcaagttgct aatcggtact gccctgaatt ttttctatgg tttggtaatt 39421 tttatacctg cttttctgct gagctattag ataaaactat ttaatattta ctatgtatat 39481 tttttaaagt attgttgctg cttaattaac tattgatgct tatatttaat gttatagcct 39541 cactcttgat cataatgggt caatgcctca aatacctaaa aaaaaaaaaa attagatagc 39601 cagacaccag gaaagaaaag tatttctttt tttaataaaa agaaatacct ttttgagcaa 39661 ctgaaatgac aaagtcacaa atttcctgca caccttaaaa tatacttaat gtaaatgacg 39721 agttaatggg tgcagcacac caacatggca catgtataca tgtgtgacaa acctgtatgt 39781 tgtgcacatg taccctagaa cttaaagtat aattttaaaa aaattctatc ttccaaagca 39841 tatcacttct caggtagaca cagtgtttat tgcaaaagat ctgatttcaa tagtatttct 39901 tcaagagtct ccccagagac aaagtcaaga agaggaaatc agcatatctg agaagaaaga 39961 tttcaggatc actttttttg agggtctgag aaaatgttta gtttctatat tatttaaaac 40021 cagaattgaa atggggtgat tcctatcctt gccacctgcc tctacaaccc caagagtttc 40081 tatctgagca tctaaacgtc ttttaggctg aaaggctcac catggctttg cttggtcctt 40141 ctctagttct tctgcagccc attgagcctc ttgacttagc acaagggtct caggtccttg 40201 cccaaaggga gtgtgctgtg ctgcaggtag actgcactga atgtcaacag aaagccttgc 40261 tttctttcat ttctctaacc cagtctcaca tcctcctcct cctccccttt tccctcccct 40321 tcctcctgca cttctctttc ctctttcccc acccctttcc tagactggcc tctattgcct 40381 cccactgaga caaaaatgaa ctgctgatca gaaagtaatg tgactagatt ctctcttcct 40441 tccctccttt ctatccttcc ttccattctc ctatgcatct ttccttaccc tcctcctcct 40501 tcactcattg ttgttgctgt tcttcttcct cttctttttc ctcctgctcc tcttcttcta 40561 cttgttcttg ttcttgtttt tgtttggttc ttgttctcct cttcctcctt ctctctctcc 40621 tcctcctcct tcttttccac caccctcccc tatctttttc ataaatgcta aactaactct 40681 tggctacctg tggtaaatgg cccttggaaa ttgcaaatac tacaaatcaa aactgcattt 40741 cagacatatt tatgatgttt gcaaaacttc agtagagcta agcagtggac ttgactcgtt 40801 tcggttcctt cacctccgtc tttccttgct caccacctag tggacgtcct tgttagtggc 40861 acttcctgaa gttaacccct gaagagagcc catgctctct agcttttcac cgtgtaggtt 40921 tgggagccta caagtacctt taatattctt ggactataaa atgagatggt tttataagac 40981 tgcatgtgaa attaggaccc atatgatgaa ggacaataaa aaggaagacc cactgatgtg 41041 agtcaatgag tcaaatgcaa atcagatttg catttttagg aaaataataa taacaacaac 41101 aaaaactctg aagctcagcg ccccatattt attatattgt ttaatcttta taacagctct 41161 ctgctataga tatgattatt atccccattc taaagagtct caaagaggtt aagaaacaaa 41221 ttcaaaaact agcgaaagac aagaaataac taagatcaga gcagaaccat aggaggtaga 41281 gacacgaaaa agccttcaaa aaatcaataa atccaggagc tgcattttga aaagattaac 41341 aaaatagatg gaccactagc tagactaata agaaagaaga atcaatagac acaataaaaa 41401 atggtaaagg ggatattacc actgatcccg tagaaataca aactaccatc agagattact 41461 ataaacatct ttacacaaat aaactagaaa atctagaaga aatggataaa ttcctggaca 41521 catacaccct cccaagacta aaccaggaag aagtcaaatc cctgaataga ctaataacaa 41581 gttctgaaat taaggcagca attaatagcc taccaactaa aaaaagccca ggaccagatg 41641 gattcacagc caaattctac cagaggtaca aagaggtgct ggtaccattc cttctgaaac 41701 tattccagag aatagaaaaa gaggaactcc tccctcactc attttatgag gccagcatca 41761 tcctgatact aaaacctggc agagacacaa caaaaaaaga aaatttcagg ccaatatccc 41821 tgatgaacat cattgcgaaa atactcaata aaatacggca aactgaatcc agcagcacat 41881 caaaaagctt atcaaccaca atcaagttgg cttcatccct ggaatgcaag gctggttcaa 41941 catacacaaa tcaataaaca gaatccatta cgtaaacaga accaatcaca aaaaccacgt 42001 gattatctca atagatgcag aaaaggcctt ggataaaatt caacacccct tcatgctaaa 42061 aactctcaat aaactaggta ttgatggaac gtatctcaaa ataataagag ctatttatga 42121 caaacccaca gccaatagca tactgaatgg gcaaaaactg aaagcgttcc ctttaaaaac 42181 tggcacaaga caagtatgcc tctctcacca ctcctgttca acatagtatt ggaagttctg 42241 gccagggcaa tcaggcaaga gaaagaaata aagtgtattc aaatagaaga gaggaagtca 42301 aattgtgtct gtttgcagat gacatgattg tatatttaga aaatcccatt gtctcagccc 42361 aaaatctcct taaactgatc agcaacttca gcaaagtctc aggttacaaa atcaatgtga 42421 aaaaatcaca agaattccta tacagcaata atagacaaac agagagccaa atcatgagtg 42481 aactcccatt cacgattgct acaaagagaa taaaatacct aggaatccaa cttacaagga 42541 atgtgaagga cctattcaag gagaactaca aaccactgct caaggaaata agagaggaca 42601 caaatgaatg gaaaaacatt ccatgctcat gggtaggaag aatcaatatc atgaaaatga 42661 ccatactgcc caaggtaatt tatagattca gtgctatccc catcaagcta ctactgactt 42721 ttttcacaga attagaaaaa aactacttta aatttcatat ggaaccaaaa aagagcttgt 42781 atagccaaga caatcctaag caaaaagaac aaagctggag gcatcatgct acctgacttc 42841 aaactatact acaaggctat agtaaccaaa acagcatggt gctggtacaa aaacagatat 42901 atggaccaac ggaacagaac agaggcatca gaaataacac cacacatcta caaccatctg 42961 atctttgaca aagctgacaa aaagaagcaa ttgggaaagg attccccatt taataaatga 43021 tgttgggaaa actggctagc catatgcaga aaactgaaac tggatccctt ccttacacct 43081 tatataaaaa ttaactcaag atggattaaa gacttaaatg gaagacctaa aaccataaaa 43141 attctaggag aaaacctagg caataccatt caggacgtag gtatgggcaa agacttcatg 43201 actaaaacac caaaagcaac agcaacaaaa gccaaaattg acaaatggga tctaattaaa 43261 ctaaagagct tctgcacagt agaaaaaaaa aaactatcat caaagtgaac aggaaaccta 43321 cagaatggga gaaaattttt gcaatctatt cacctgacaa agggctaata tccaaaatct 43381 acaagaaact taaacaaatt tacaagaaaa aacaaacaac accatcaaaa agtgagtgaa 43441 ggatatgaac agatgcttct caaaagaaga agtttatgca gtcaacaaac atatgaaaaa EPI-109 982

43501 aagctcatca tcactggtca ttagagaaat gcaaatcaaa accacaatga gatgccatct 43561 catgccagtt agaatggcga ttattaaaaa gtcaggaaac aacagatgct ggagaggatg 43621 tggagaaata agaatgcttt ttacagtgtt ggtggaagtg taaattagtt caatcattgt 43681 ggaagacaat gtggcgattt ctcaaggatc tataactaga aaaaccattt gacccagcaa 43741 tcccattact gggtatatac ccaaaggatt ataaatcatt ctacgataaa gacacatgca 43801 cacttatgtt tattgaggca ctattcacaa cagcaaagag ttggaaccaa cccaaatgcc 43861 caccaatgat aaactggata aagatgatgt ggcacatata catcatggaa tactatacag 43921 ccataaaaaa ggatgagttc atgtcctttg cagggacatg gatgaagctg gaaaccgtca 43981 ttctcagcaa actaacactg gaacagaaaa ccaaacatta cccattctca ctcataagtg 44041 ggagttgaac aatgagaaca catggacaca gggaggggaa catcacacac tggggcatgt 44101 caggggatgt ggggctaggg gaggaacagc attaggagaa atacctaatg tagatgacag 44161 gttgatgaat gcagcaaacc accatggcac atgtatacct atgtaacaaa cctgcacgtt 44221 ctgctcatgt atcccagaaa ttaaagtata atttaaaaaa agtttaaaaa aagaaagttg 44281 ccttagtcac ataactagta agagacatgg ttgggaattt gaacagaggc caatcagttc 44341 caaatccatg ctcttgatca ttaagctgaa cttatggcag gaacttggaa gacatggtaa 44401 aatggggaaa aacgtggagc cagggagact tgtgaaagtg ccagtgctcc cactataccc 44461 tgaaagaagt atctagactt acttttttct aagtcctctc ctctaattct ctcaatctct 44521 ctctctcttt ctctaagaga tgggaatgct gctctgtcac tcaggctaga gtgcagtggt 44581 gcgatcatag ctcattgcac tcaaggaatc ctagggtcta gtgccccttc tccctcagcc 44641 tcccatgtag ctaagactac aggcacatgc cccaaccctc gactaatttt tttatttttt 44701 atttttgtag agacaggatc tcactatgtt gctcaggctg taattctgtc ttgaagcttg 44761 tccaatcagg ctttcagcca caccaattcc ctgagactgc tctcaccaag gtcctacact 44821 tcactaacac aaacagccta ttctccatcc tcatcttact tcaccaggga gctcctggtt 44881 ttcctcctac ttcactggct atttcttctg tatcatgtgt tgattctccc tcatctcccc 44941 aacctccaaa cccttggagt actccagaga tcaccgcttt gctcttctgt gtctaacctc 45001 actaacttgg tggtccaatt cacactcttg actttgaata ccatttaaat gcgaacgaat 45061 tctaaattct gtacaaccag aaccattctc ctgtagccaa atgcctactc aacatctcca 45121 tccccaaaca aatttagttg ttcaataagc ctctcatatt ttacatatcc caaactgaac 45181 ttctgaattt ctcctccaat ctgtagggct cttcccacag cctttccatc tcagtggatt 45241 ataactccat ccttccagtt actcagacca aaacttttgg agttaactga gacacctctc 45301 ttttttttca caagtcatat ccaatgtgtc aacaaatttt ggtagtggaa atattgcggg 45361 attttttaag aaatcagaga gaccgatggg gttcaggagg atatttatta tttaggtgca 45421 ctggccaagt cagattaaca tccaaaggac tgagccctga acaaagagtt aagttacctt 45481 ttaagcattt tgtggggtgg gagagagggg tatctgtgca gggggaagca tactacagaa 45541 gtgagaaata aagacagtta ttcaattaat tgagacatgc attacatcat ttcttacttt 45601 tcaagaagaa acatgttttg cgacttgagt ttatctgtct agtgaccttg cagctgcaca 45661 gctagagaaa cagggtcttc acaatgcctg ggaaaggagg agaggtaagt ctcactagcc 45721 acagaaaaac aggcagttaa tttttaaagg gctccagctc tttctctttc tcagggggag 45781 ttgggttttg ttacatacaa ctgagtttcc gcttacacat tatttaattt cttttaattc 45841 ctgttccaaa agaagccaga tacaaaaggt tacatgttgt ctgattccat ttatatgaaa 45901 catatagaag aggtaaatcc atagagacag aaagtagatt agaggttccc aggggctgag 45961 gaagaaatgg ggactaactg cttatagggt acagagtttt cttctgataa aaatattttg 46021 gaactagata gacattttgt taggccattc ttgcattgtt ataaagaatt acctgagact 46081 tggtaattta taaagaaaag atgtttaatt ggcttacact tctgcaagct ttacaggaag 46141 catggtgccg atatctgctc agcttctggt aaggcctcag gaagcttaca atcatggcag 46201 aaggtgaaag gggagcaggc atatcacata gcaaaagcag gagcaagaga gggatgtggg 46261 gaggtgacag tcacttttaa acagccagat cttgtgagaa ctcattcact atcatgaaga 46321 cagtaccaag aggatggtac taaatcattc atgagaaacc ccaccctcat gatcaaatca 46381 cctcccacca ggccccacct ccaacactgg ggattacaat ttgacatgag atttgagtga 46441 gaacacggat ccaaaccata tcagagatgg tggttataca atgcgataaa cgtcactgga 46501 ttgtacactt taagatggtt gttttatgtt gtgtgaactt cacctcaata aaaaaaaata 46561 tttaatgtac attcagccaa aagaagattt ggaataggaa aggtcatgga gatatattaa 46621 cagccatttg atgggtggta aggaaaagag tggttattag actgttttgt ggccctcaaa 46681 aggtagaact agatcgagtt ggtgagcatt ataaaaccat cacaaaaccc tggagagagg 46741 acccagtgct gaagaaccgt ttgcctgcca tgagacatga gggaagtacc agtgaatgcc 46801 attgaaagca gcatccctgg gtccaaggga tggtcaaagg accactaccc aacccttccc 46861 tagcctacgc ctccattaca gatgaccgca agatttattt gctcattgct gccaaccaag 46921 gctgcactca ctgcagttgc tatcagttta tcatgggtaa aaggaatgtg cagtagagaa 46981 ctaactaact gcccacctac ctccacaatc ctatcaggac aaatcaccat ggctcacatt 47041 tccttacatt tggcatgtaa gcccctctta ctgtctgtca tctatctcct acacagttca 47101 cctaaactgt tctctcctga cccaaccttg attttcatcc caaatgcttc cttgccatct 47161 ctgggattcc tgtcttcacc atcaccaaac tcccctcaat cttccagttt cctgttcaaa 47221 cttttctcct acctccttgc tttgtcatta gcccgactgc ctccctagga catcacttcc 47281 cctgcagatc tctcaagatg acaatattta ttctccacac agcacatact tcagggttgg 47341 aaggcagggg caatcttctc ctttataatg agtgcctctt atatatgttt attcatctgc 47401 cctcttgtaa aacacacaca cacacacaca caaagaagaa ataaaataac tctgcttctt 47461 tgaagcttgt gacactgaga taaaccatct cactgtcctc attgtagtga cctctcaact 47521 cctcatgcaa gattggcttt ggcacctagt tcctgatctt cctttccctg taagcacttc 47581 tcatagtctt acgggacttc accatccatg gcacaaccaa taccacagcc cagatcctca 47641 gctctccaat gacattttcc tccactagac ttgagctacc tccttcccta ggcacagcct 47701 caacctcgac aacacctaag actgtaccgt ctctaaagtc acatgttcaa acacttcact 47761 ctttaaccac tgtctcctat tcttgcaagt gtattgctca agtatctcat tgcaatgctt 47821 tttacttcta cctcattgaa cctccaggcc attaaacatt tccttatttc taaccatcag 47881 gtttctcctt acttgtttgt ttgtttattt gtttcttttt tttttttttt tttgagacag 47941 ggtctcactc tgttgcccag gctggagtgc agtggtatga tctcggctca ctgcagcctc EPI-109 983

48001 catctccctg gttcaagtga ttctcatgtc tcagcctccc gagtagctgg gactacaggt 48061 gcatgccact acgcctggct aagattttgt atttttatta gagaaggggt tttgccatgt 48121 tggccaagct ggtctcgaac tcctaacctc aggtgatcca cctgcctcag cctcccaaag 48181 tgctgagatt ataggcatga gccactatgc cccacctggt ttctccttat ttatttcaag 48241 tctatgctgc actattaaaa ctgccttgac aaaaattata atagtgagaa aattatgaca 48301 gtgaaagaga tctgaaataa tcaaccccca tcttgccttt accttccaga ctgcccttaa 48361 taattcctga gcttgggcca agctatcttt ggcagaaatt tagtttatag tttaaatgat 48421 aatagccctt ctccaaaact aaactgcctt tgtaaaacta ataaaagacc accaatgaaa 48481 ggttaggagg atgagaggag cctgaattct gctaaggtgt agatgtaaac aattaccaac 48541 tgttattccg gaggtcacaa gatttgcaac atcgccaatt actcctgcag ataacagcac 48601 tatcatagaa tctgattggc cttttgagat gtcttttcag attcttacat ttcaactggt 48661 ggctctacct ggacccatca acaagtcctg tggctccacc cagaagcaga cttaacatgc 48721 acaaggacca ttttccacac cgctatgatt gcatcccaac caatcagcag caaccattcc 48781 tctgcctgcc aaattatcct tgaaaaatct tagccttaga attttggggg aggctgattt 48841 cagtaataac aaaaccccgg tctcccattt ggctggctct gcatgaatta aattctttct 48901 ctattgcagt tcccatcttg ataaatcacc tttatctggg cagcaaacaa aaggaaccca 48961 ttggacagtt acactgttgg cagatatatc ttgcttccaa aattggattt ttgtttaatg 49021 aatttattct gttttcttga tatttacaac tgtgaatgtt gtgtctgaat tctctttatt 49081 tcttgttgaa aagaactata ttgctacagc cagtacatac agatggatag ctaattactc 49141 aacacggggg gatgtgacca tcaccgcact gtgcaaatga atgttaccca ttgtccactt 49201 ttcccaaact acatagtgtt atatggtata tgacccaatc aacggtggca aagctccaga 49261 aataccacat agacatcagg gacactttaa actaatcagc ctatagtcct ttttcagtaa 49321 tttccaaacc tggttgtgca tccaaatcac ttggtaacat taaaaaaaca aaaaaatata 49381 cacgcaacat tcgctcccaa tcctactgaa tcagaatatt ttgggttggt tcaggaacat 49441 tcaggagttt ttcagggtcc aaggtttata taatttgagg tctctctttg agaaaaggaa 49501 cgtaaaagcg tcttgctttt atagatctta caaagatgta ttaccatgta aacacattcc 49561 taggacccag gcccttgtaa tttaaaggtt tatctaagta atgggccctg aagcttaatt 49621 ttcattatct tcagggcaaa ttacctgtgg gttagggttt aggaatatat ctctctgtgt 49681 atgtgtgtgc acattagcat gtacgcttgt gtggattttt tttttttttt tttttttttc 49741 tgagacagag tctcgctctg tcgccaggct ggagtgcagt ggcgtgatct ctgctcactg 49801 caaactccgc ctcccaggct caagcgattc ttctgcctca gcctcttgag tagctgggac 49861 tataggcacg caccactatg cccagctaat ttttgtattt ttagtagagt tggggtttcg 49921 ccatgttggc caggatggtc ttgatctctt gacctcgtga tccacccgcc tccacctccc 49981 aaagtgctgg gattacaggc gtgagtcacc atgcccagca cttgtgtgga tgttttaagc 50041 tcccaggtga gtgaatacaa aactagatct ttcccttctg tagcatctgt actgtttact 50101 ctatgcatct caatattttt tcttttagta tctttccttt ttctctctta ttacttcctc 50161 ttgtgctatt tttacacctc cttttttaaa aaattttttc ccttttattt ctattgacct 50221 ttagccctca caatgattcc tacaagcccc atttctgtaa atggggattg aaataattgc 50281 tggacttttg agagatagat atattaaatt gcaaactggc agtagtgggg gcagttgata 50341 cataactagg ttttaaagtc tagccttctg agaccactca ttccatttgt gaaaagtgat 50401 tctacttctt attatgagcc aaaatatgca ttcattcacc catgcattga tttattcatt 50461 caataaatat ttgttggatg tccactctgt atcaggaatg tgctaggttc tgggaataca 50521 gcaatgaaca aggtaatttt tccctacccc taaggaactt agagtttagt ggggaagaca 50581 gacattaaac aaacaattgt gcaagtaata atctataatt atttattaca attaaaggaa 50641 ggaagagaca tatggattat gagggcatta aagaggagac ctagtgtaag tagccagttc 50701 tcgtgaaggg acatgtatta gttggagttc tccagagaaa cagaaccaat ggtgtgtgtg 50761 tgtgtgtgtg cgtgtgtgcg tgtgtgtgtt ggggtgtggg ggtgtggtat tttttataga 50821 aattgtctca cacaattatg gaagctgaga agtcccatgg cctgctgtct acgagctgag 50881 aaccaggaaa gccagtggaa tacttcaaag tccaaaggcc ctggaaccaa gagtgccagt 50941 gttggaaggc aggagaagat gggtgtccca gcttaaaaag acagtgaatt cactcttttt 51001 gctctacata gggcctcaat gggttggatc atggccaccc acattggtga aggcaatcct 51061 cttagtctac caattaaata ctaatctctt tggaaatact ctcacagaca cactgagaaa 51121 taatgtttta tcagggtgat agaaatcttc tggagttaaa caatggtgat agctgtacaa 51181 tcacatacat ttttaaaggg tgcgttttat ggaaagtgag ttttatctaa ataaaatttc 51241 taagaaagag acttaacaca gagataaaca taagcacatt tattgtcaac ctttatagtg 51301 ttatgtcaaa taggtctgac ataagcttaa ataaatatat actttaaaaa ttataaaata 51361 ttttaagtta taatttaaaa ttctcaataa aactcaaaca caaaccacac tggtatttca 51421 cacagctaat ttctaatgca gtttacataa atatttacaa cacttaaaca atttcaaaga 51481 aaataacact gtattccata catagcctga tcacagtagt tgttctctct tatttcccag 51541 agtttttctg cccctttaaa agaacctctg ctgttctgat ccttatcaca tctctgtttt 51601 gactgttggc tttgttgttg ccagtgttca gccagaactt ctctgaaact tttttttcaa 51661 cacatgctaa gttaatggaa gtgtaggaga gttttgattc tcacactcct caaggctaga 51721 gcagctttgg caattactga ctgagaattt ttcattgcca gtgatcaact gaaaactgga 51781 gattcctttg gaattgttaa atctgcttat aaataaacat aaatgcttgc tcacacaggc 51841 attcctctct tccagagcac cctaacatac agaagaaaac aaatagggaa taactattag 51901 acatcttcat tcgttaaaaa tctaccagat gactctttta catggtgagt ttctattgtg 51961 aatttaaaat cttccataat atacaagaat tatgtttaca tatcatatct gacaaacatc 52021 tttgtaggaa tgcaaagcac atccatcttt ctgtattctt ttccaacaaa gacattcata 52081 aaattatacc tttgtgtgtt tgcatttatg cttttattag ttcaaaacgt ttggcctcat 52141 ggaagttttt catcgtggaa accacatatt tctgaaaaaa tatctgacaa tatacaaacc 52201 ttccattcag tttttactct ccaattctac catgttttca aaaaacaact gtagtaaaaa 52261 cactcagaac tttattctgg ttaacatcat gccttgctag gggacaatag tttccctttt 52321 tgaaataaat ttaaaacaga tgtaacataa tttgttaata aacaatgagg gggtaatcta 52381 gaataagtaa cttttaccat atcatagttg acagcattta caagtttttt aagtccctac 52441 cacacttgta ttgaatgaag aagtatggaa gattataata tattcaatgc aagtaaaaat EPI-109 984

52501 atcacaatcc ttaagaactc tttaagaagc actgaatccc atagggatga aagtgattaa 52561 attgtgcata gtaaccctcg cacagagcat tcagtaggat ttgcaccatt aacaaccctc 52621 catgcatttg cctgtgggca ttcaacatct gtcatttttt taagttataa tatttttagt 52681 catttttttc ctctaaactc tggataatta ttattcattc ttatgacagc aactgtgtaa 52741 tcagctgtcg aaacactgtg aagggcaaaa gaaagaaagc cacaaaatat tgtgtttctg 52801 tgccaagatt ttacagcgag caagggagag ttagaaaagg aattctgaga tttcagagtc 52861 ttggtctctt cacctttgct tggaagaaaa tatcctttcc cttcattagc caacactttc 52921 ttgatcctga gagtaggaaa gggaacactg agtcttttca gttgaaggcc gtccttgcct 52981 gctggacttt gatctattga agtggtgatg ggtgttgcgg tttcagccat aaaggcatct 53041 ggcatagtag gcaagaaggg ccagagaccc gaggagagtt atctgtctct gttaacttca 53101 gtgtatccct ctagttcccc agatgcacct gtttctgtaa atataaacat gcatgtcatc 53161 agaacactta atattctgca tactgatcat gacaacaaaa tgtaccttct aacacagaca 53221 ctctcactag gatagaccat gtaggaacat cgaattctat tcagttagga cagtgatgat 53281 gtctacatat tatacctctg tcaaaaccta cagaatatac aacacagcac agagtgaatt 53341 ctaatgtagc ctgtggacat taatgaataa taatgtatca atattggccc atcagttgta 53401 acactaatat aagatgttaa taacaggggg aattgaaggg gtggtgggga gatatgttgg 53461 aactctttgt gctttctgct caatttttct gtaaacttaa aaccgcacac acaaaaaaag 53521 ttattttaat tttttaaaaa gtattcagag ggacttgacc tttccaaatt ctctcaaagc 53581 aggtcggagt agttaagaac acaaatttta gaaccagact gccagagttt gaatcctggc 53641 tacaccactt actagctttg agatttcaga caatttactt aacttctctg tctcattttc 53701 ttcatctgtg tgataagaaa taaagtaaca ggccaggccc agtggctcac gcctgtaatc 53761 ccagcacttt gagaggccaa ggcgggtgga tcaggagttc aagatcagcc tggccaacat 53821 gacgaaaaaa tacaaaatct ctactaaaaa tacaaaaatt agctgggtgt ggtggcaggc 53881 acctgtaatc ccagctactc aggaggctga ggcaggagaa ttgcttgaac gcaggaggtg 53941 gaggttgcag tgagccaaga tcatgccact gcactccagt ctaggcaaca gaatgagact 54001 ccatctcaaa attaaaaaaa aaaaaagtaa aaagaaaaga taagaaatat agtaccagcc 54061 cctatctcag agttcctagc ttagaaaaat tcccagaata taataagtgc aatgtaaggg 54121 tcagctatct tcattattat tatctatcat aaatgaaatt acacaataaa gctagatccg 54181 tttctttcct ctccttctac aaaaaataaa gcaactttcc agaacaatac ccaggtgatg 54241 atttctcccc tgctccctcc ctaagatatt ggcaagtttg gagggttcaa ggagaaacag 54301 agcatgtaga gaagatacct ctctcataac catttgtgat ttacaagtct tacctgattc 54361 ttttgaactt aaaggatgta agaaggcttt tggtagcttc catctgattc aaggctttgg 54421 cagctgctgt ggaatacatg agaacactag gtaaagcact gtcttccaac atgaagagag 54481 aaaaatatgt ggaatgttca atggcatgct ttgtataaga atgcaactta cctggcagga 54541 acaaatttct ttgctgcaaa agaaaagaca aacaaccatt aattcagact aaatgacttt 54601 taaggatata ttaaatccag atacaatatg acttaattca tcaagtgttg caaactcgat 54661 gcttcagggc ctctgtaata atcagagcac aagcatggct ctgtggcatc tagggtaaaa 54721 tgcaaagtgc acagccatcc aaagggcata gcagcttcct aatgccagca aatagctacg 54781 gggtcatctt gcccaattca gctcccaatt tttcatgaga agtccaaagt cttaatttaa 54841 atgtgagatt tcctattttg taaacgtcag aacttaactc aaaaatgttt taagtactct 54901 taaacatgta agccaaacaa accatgagtg tagtcagatg tgcttccata ttccttatga 54961 gagactctca aatttaagcc tgtactccaa ataaatctcc ttaggaagaa ttttatccat 55021 tttccttaga gtgctcatca tggcagttcc attgcacaat tccgggaggc atcatataat 55081 tcaacatgaa tagcaccccc tggagttgta caatattagg cacgactaac atttttattt 55141 cctgaaacac ttcccacact gagttgtact actaactctt ttcttaatac ttctgcttaa 55201 ttatactgca ttttatccag attctaatta ttgtttaaat cagtaagcaa gaccatgact 55261 tatcaatgag aaagaaatgt attttcaaaa acatttttga agtacattca taaacttcct 55321 cacctttccg taagcatttc cgaagccaga ggagaaatgg tgctaatgtc aggagggaga 55381 gtccagcagc agaaagtcca gctaccaagg gaatgttgga ctcagtggga gctaaggaag 55441 taagagacga agaaaggtca tgaggaagaa ttgatgttaa agtctctccg tcctgtccct 55501 ttggcctttt ttctgtacat tcattactag gagcagaaga gctatctagt ttaatacaag 55561 aagcagagat gtggcattac aggcctttga gatctgctcc aagccacctt tgaagctatt 55621 tccaccattg gcaggcagaa ctctaacttg ccaagctcgt tcacaatacc acaccacacc 55681 ttggttaata aacactgcac ttgcttgctc tcttgctctc actccctctt gttttccatt 55741 tcccctttct cctctcctct ctctgtctcc tttttccagt tgtcagaatt ctaccctttc 55801 catcaacatg caacttctgt tttttctcta tccccataca acttaatatt cacaacttgt 55861 caacctgggc gaactttctg gtttggatat aatgaatagt tgattactgt aacaagatag 55921 ctcccccttt ttctttttaa tcaccagaca accaccatca atcaatgcat caccttcaca 55981 ggtaggtagc aggccagacc agtgtcctgt ggctccacat gtccgagctg cagagccatt 56041 gagcgtccat ccttcaggac aggcgaactt gcacacagtg ccaaacacgg gctccccact 56101 gcagctcatg ttgatctttc ccggaactgc caggcttgaa cattttacca ctgcaaatgt 56161 taggtacaca ggcagagttt cagaaaaatc tactggaaaa cttccaaaac ttgcttaaaa 56221 gtcaacaatg aatgtaaagt gtaagcgcta cttagttttc agcatgtagg aaattaggac 56281 caaacccctt tggggcaatc taggttcaga aactttatga agtatttgac ctgtacccta 56341 aaaaagtctg cactcaattc taccttggca ggaaggaacc tcttctgtcc attgtccctg 56401 agatgtgcac tcaagttgag ttgatccatg taattcaaat ccctcctcac agctgaaggc 56461 acaagaggac ttgtaggtga attctccaat aggggaatga gcacacctca ccaaaccctt 56521 cgggggctgg tggacagcat cgcatctcac agctggaaca cacgagagag cactttagaa 56581 gtttgtttgc atctccagca atacgtttcc caaggtaacc aagttcccaa gctcttcaat 56641 agttcttttt atcttaaaat aaaataaaaa caaagactgt accttcacat gtgggcttct 56701 cgttgtccca ctcccctgtg gggccacatt ggagcctttt ggatcccttc aacacaaaac 56761 cctgctcaca ggagaactca cagctggacc cataacggaa actgccagaa gcactaggaa 56821 gacaattcat gtagcctcgc tcggggttgg acaaggctgt gcactggaaa gctgagacat 56881 caaaatgatg gtcagaaaat attgcagtgg aactagagag tacttggcgt ttgttgagtg 56941 aacccagttc attcaagcaa cacttggaga actgaagatt ctttataatt ccctggacaa EPI-109 985

57001 atgggaagat ggctgtgttt tctttgaatt tcagccccct cactgatcat ggcactaatt 57061 aaaagactaa ttaatcagaa cattagttcc tgagcactgt tcttctaaca cacaaaataa 57121 attatggtcc aaggaaagat ttcacgcagt ctgaggacaa catatgggtc atggatgttt 57181 atagatggtg ccaaaaagaa agaaaagaaa gcacccctat aaaatttgtc tgttttgcag 57241 tttggttttt gtgttatgtt ttgctactgg aaatcattct gtgctggctt tggctaggac 57301 aaggccagtg cctgatagta aaaactgctt gttttcaata tccttgctct cactttaaag 57361 tgaattaaaa tttactgctt atatatgcat caatactatc tctgtagctg acaccatgct 57421 tgaaacagtc tcatcactgc taattatgag ccatttcaga agacaggtgt gatgagagtt 57481 ttacattcaa atcatgttct cattattctg ctttccgaat tttctaatat gattccttta 57541 gattaagaat tctgtctatt ccatgctaat gtctacaaag ttttatcagc acatcacagt 57601 taaaaaaaaa cagcaaagaa ttcattctta acacatatga tcctttccct ggccaaacat 57661 tagttctttt aaatgaatct caaagatacg agggttgctc atcaaatctg atttctatag 57721 ttaaagtggg tattggtttt ttttttcact gtccaagttt gaagatggtt gttctttaag 57781 aaagtataaa tcgaaggatc tcaagcttac cttcacaaac tgggatttgc tgtgtccact 57841 gcccttgagt ggtgcattca acctgggctg gtccctgcaa catgaagcct tcctcacagg 57901 tgaagttgca ggatgatttg aaggtgaact ctccagcagg ggaatggctg cacctcacag 57961 agccattctg aggctggcgg acggccctgc atgtcacagc tgtaacaaat atacgcattg 58021 atattagcac ggcctagaat tagcttgccc atttccagta tgggttgaga gaaagaatgt 58081 tcacagtaag tctccatgtg gaacaactct acctttacac gttggcttct cgttgtccca 58141 attcccagat gaggtacact gaaggctctg ggctcccatt agttcaaatc cttcttcaca 58201 gtcaaatgta caggttgtgt tccatgggaa gcttccaggg ttttggaaac attccacgaa 58261 cccattggct ggatttgtca cagcatcaca ctcaaccact gaggatttta aagagcacca 58321 tgaattttac agaagaatga tcttttcact tcctattgag ctgggtgcct aacagagtga 58381 ggaagctgcc ttcaaagggt agatcccaaa gtcctatgtc aattcttagg gacatgcaca 58441 gccagaataa aagcttttat tctttttcat ggatattcta tcttttctga tttccacttt 58501 gcctatgctg agtggtctct aatctatgtt atcatttacg tgaggtaaaa atttaaaaaa 58561 aatagattcc agattaggag ttatgactag tactgacata cgtaggctat tcatttattt 58621 tagcccatca gagcctgaag aactgatttt tctttttttg gcctctggtt cagaaagata 58681 aaattaagag agaaaaagag atactaagac tgcttgacta tcatggtctt aagttagtcc 58741 catggcttgg aaaagttaaa cagggaaaca agatgagaaa tccattgaga tttctagagc 58801 tttattgttt tatggtctcc cttacaaatc accagagcct cagaaacacc catttcaagc 58861 atagaataaa aaaacctctc tcaacccaag caggtactgg gttggcaata tacattggct 58921 gagagaacaa attgtattaa aaacaaaaac aaaaaaaaaa ctttccctga agttttgaaa 58981 atgtaagttg aatcaaaaaa cagaagcaat gagggatgag ttacagaacg ttctgtgcat 59041 tctcagaggg atttaccatt gcaggctgga ataggagcac tccattctcc agaggacata 59101 cactgcatgg tctccatgct gcttggcagg taacccctat cacagctgat agagcaggaa 59161 gaattgtagc tgaagtttcc cagtgggtga ctgcaaacca ggcttccatg ctcaggggat 59221 tccagggctg tacagttcac aactgaaaaa gaaacccaaa tcagttctgc tcatctctca 59281 cctttaacag ataagaacac tggaaactag aactacagtt tggttttttt tttttttagt 59341 ttaaaaattt ataaaatttc taatggaatt tgtaaaattg actgtaattc tacccctttt 59401 cttttattca agaaaatgct gatccataac aacaacaaca aaaaagcagt gatgacaacc 59461 ataaaaaaga aatattgagt gatatgggga gagtagtgta attgtgttta cctcaaaact 59521 gttcaaatta tatgaacaaa cacagcaaac ttaggtacca caacaaattt cttgttactt 59581 ttctcacaac tgctaaaaat actacagtaa gcttccaacc aggatgagaa ccattcacaa 59641 agctatattt caaatttaag tactagaata cattacaaat tttaaaaccc taatgctgca 59701 ctgtctacta tagtagccac tatctgtgtg gctactcaaa tttaaacttg aattcgttga 59761 aatcaaataa catttaaaat tcagttcctc agtgtcacca gccacatttc aagtactcaa 59821 taaccacatg tggctcatag gtacacactg gaaaacacag ctatggaaca tttccattat 59881 cacaaaagct ctactgcaca acgctgtgct aaggaatctt ggagagaagc tcatctaact 59941 ctcttaatgt acaaatttag gaactgagac ctcatttcat tcaagtgact tgctccatgc 60001 tacacggcta gtcattacag agccagaggc cagagcatga accaagatac cctggactct 60061 gtaactcact catttctact gcaacgtctt gttaccacct agatgaggtg agtacatgtt 60121 cctcgcaggg acacagaatt acagtttatt gaatgtgtcc tgtgtgccag gcaccatgta 60181 accatgagcc tatgaagttc acactattat tatcctcatt ttacaatgag aaaactgaca 60241 tagagagtta aactatcttg tcaaggtgcc aaaataaata actggtgaat ctaggactca 60301 aacccagcag ggtctgactt catagtctca gctcacgatc accatatgac accatctgca 60361 ccagggaagg gaaggcatgc agacctgact ctaatgccag ctaggacgtg agatggtgct 60421 accatctcaa gtgaagaaag aggcaagaac cagacttact ttgctcacac ttgagtccac 60481 tgaagccagg gtcacacttg caagtgtaat tattgatggt ctctacacat tcaccgtggc 60541 cactgcagga tgtattggta caggcagcta cggaaaatac aaagcatgat gaggaggact 60601 attactgtgc ttatactgag tgcctttgat tttagaatca acagtgtgca acagagacat 60661 cagcagtcct acagagtgcc atagacttta actgaagtgt tttacaaagt tccaaatctg 60721 agtttcaggc ccacctatcc taaaccttga tgctaatgta tagctgtggc tggcacctac 60781 cgtagaaaat ttacttcttc acaaactctg aagacagttc ccctaccaca aataaacaag 60841 taattaaaat atgtattgtg tgtgtgcatt tttatatgta aagaactaca tatttgccta 60901 cagtatttat atatatttta tatatataca tacacacata tatgtgtgta tatgtgtgta 60961 tgtatatata taaaatgtat ataaatgctg taggctatat atatatacac acacacatat 61021 atgtgtgtgt gtatatatgt gtgtgtgtgt atatatatac atatccacat attcttgccc 61081 acattcacac aaaacagcaa aagagagaaa ctttagcagt taaacagaat cttttggaac 61141 ataaaatgac cacaatagag agcagttttt gcatgctgta aatttgccaa gatgcccaca 61201 cactgaaact acctcccact gctgccgcaa actccctacc tgtgtagcat agggcaagct 61261 tcttcttgct gcacctctca tcattccaca tgcccacatc tttttctctc ttgatgtaga 61321 tctccacgca gtcctcatct ttttgcctat tgttgggttc acctggagcc cagttcttgg 61381 cttcttctgt cagaggtttc tgggttccta cccagaccca cacattgttg acttttctga 61441 ttccaatcca gtaataactt ggtgaatagc tcaatatgga gtttaggtac tcaatctctt EPI-109 986

61501 ctttgttttg aattgcaacc aggtgtgtgt acctttgctg acaataagca ctggcctcat 61561 cataagtcat agcttccgtg gaggtgttgt aagaccaggc tccactctct ttaatgagaa 61621 gcactagtgg gagaaaaaga aaagaaatgg tagagtttgg tactgttgtg gtttaactct 61681 gacaactgtg ctttttattg tcttattttt ggcaatgttt gtgacatggc ccagactttt 61741 ctcatctttt caaaagtaag aagtacgtat gaagaaacag cgacttattg tttatctctt 61801 ttgtgactgc cacccactag gtaccttatc cacactcact cacaacatta tagtataccc 61861 attttgtagt agaataataa tcagaataac taagctttat tgagcactta gtatgcacca 61921 agaagcactg tatgaggtac tttccatgaa ccatgctatt gaatcctcac aatgcatctg 61981 ggaaataggt cattatgatc cacactttac acttaaggaa agggagacac caagaggtaa 62041 agtaaatgac cccaagccca gggaagaaca cattgcaggt agaggtcaag gatgctgcca 62101 gatatcctgt gcaggacagc cccagacaag caaggatatt tcagtctgaa atatctatag 62161 tgcgagaatg agaaatcttg gtctaatggc actgacttac ccaaagtgag agctgagaga 62221 aactgtgaag caatcatgac ttcaagagtt cttttcaccc aaaggtttag gcttgaaata 62281 ctttcctggg gagataaaac acaaaatgaa ttaaagaagg aaatcgtggg tagctagtta 62341 cattattcta ccatgatgtt taaggcagca tcctaagatt ttgggcaaag gacactagtg 62401 caataatctt tatttcagag tttaatcaaa taaataaaca aattttaaga ctttcattat 62461 ttaggtcaaa gagaaaagac aggttttagc tacaatacaa taagagcttg tacagatgtg 62521 gtttttatta gaaggccttt tgcatatctg tgtttcatgg cccgaggctg cccttataaa 62581 gcgttctgca cttaccgttt tgggaagcag ttgttcaaac acaggatctc tcaggtgggt 62641 atcactgctg cctctgtctc aggtcagtat aggagttttg atgtgaagtc agccaagaac 62701 agctgaacac tacttcggct gaggcccttt tataggaggg attgcttcct gtgaataata 62761 ggaggatatt gtccacatcc agtaaagagg aaatccccaa tggcatccaa aaactttccc 62821 gggaatatcc acgatgctta aaattacaat gatgtcagaa actctgtctc ttgaagctac 62881 ttcacctttg tccatgcctt tatatcgtat atgcaatttt attaatatga caaaaatgca 62941 tgatttttaa ttataataac ataaagtcta tgtctttaaa aagttgtaaa actttgcttg 63001 ttagtagtgt ctctcatgta gttgtggtag taattagaat ttcagaaaca gaaggaaacc 63061 aagaataggt ttgtcatcca tagtctacta ccttcaattt ctcattcata gctgtggata 63121 accaatcact actcattttt tcttcctttt tcacctgcca attcaacata tttaacatgc 63181 actgtctcac agaggaatga ctcacaaggt agatattaat cttcagattt tgcacggcag 63241 ttatgcctaa attaaaatat tatctaaaaa taatatctaa cactcaaatg gttaaaataa 63301 tgccttattt taaaaaaaga aaaatgggaa atagatattt acatctggga aagtttcatg 63361 gtttgttcag tgaaaaaaat aaaaaggagg ccaggcacag tggctcacgc ctgtaatccc 63421 accactttgg gaggccgagg caggcggatc acctgaggcc gggagttcaa gaccagcctg 63481 accaacatgg agaaacgcca tctctactaa aaatacaaaa ttagctgggc atggtggcgc 63541 atgcctgtaa tcccagctac tcgggaggct gaggcaggag aatcgcttga acccgggaag 63601 tggaggttgc agtgagccaa gatcacgcca gtgcactcca gcctgggaaa cgagtgaaac 63661 tctgtcttaa aaaaaaaaaa aaaaaaagaa aagaaaagaa aaaaaataaa acggaaaact 63721 atatatatat atttaattgg tcaaaatttt gtttaaaatt tttgaaatgt taatgtgcaa 63781 agaataaaaa ttcttccaca atgttaacag tgactaactc tggatggcag gatttgggat 63841 aatttttata tccttcatta ttattttcag gattttaaag tttttttcaa tttccctttt 63901 tttcaccttt atagtaacaa gaatacagtt taaagaaact tgtctctagg ccaggcatga 63961 tggctcatgc ctgtaatccc agcactttgg gaggctgagg tgggtggatc acctgaggtc 64021 aggagttcca gaccagcgtg gccaatatgg tgaaaccctg tctctactaa aaatacaaaa 64081 attagccggg gtgtagtggc gcatgcctgt aatcccagct actggggagc ctgatgcaag 64141 agaatcgctt gaacccagga ggcagaggtt gcagtgagct gaaatcacac cattgcactc 64201 cagcctgggc gacagagcaa gactccatct caaaaaaaaa gaaaaaaaga aaaagaaaag 64261 aaaagaaatt tgtttccaaa tgcaacagaa ggagatgtat gtggtatcct atattcctgc 64321 tcttcatttt gacatttctt ctgggtgatt gtatacattc cccatctctg catcttaccc 64381 tatctaaatg atggtaacag taaatgggga tcattttaat ttccatattc tgtaggtttt 64441 cagagctcaa gtcaagctaa tattctatat ctacagcctt tcaaaatagg aggtctatct 64501 aaaaatgtac tgtcagcaga cctgaacgag tagtggtaaa agcctcgttt ttctctttac 64561 ttgttagcac tggtctttct gtgttcataa agatgtcaag acccaaaaaa aaaacaagaa 64621 aagagaagaa aaattccaaa aaagacaact gattagaaaa aaataactta attaacgaat 64681 ttaattcaac ccctatcaaa aagcatagaa tttattccct ccaccttacc actctcttac 64741 atgatccaga tactgacatt attccaattc tttatcccac tttacttagc tcaatgtggt 64801 tgttgcttca ataaattcag aagagtaatc actcatatag tgtttattta gattttaggg 64861 cagaatgtca agttgggtta atacattatc tgtatgtatt ttatttttaa taaagtatga 64921 atacataatc tgctattttt aaaaagcatg gtcaaatgta tagagtagcc aaatcttaaa 64981 aaacaattta tcttcgatat caataaagta cctaataatt atattgctaa tagaaattag 65041 tcgttaacat ccctagataa ctaactttat tattgcgaat ttttcataac taagtttata 65101 gtttatctct tccccttttt aaaattagtt caaagatatc taaaaatagc cccagtggtg 65161 atgaagtttc tattttactt acatatatat gtcctggacc cccaattata atctctaaca 65221 tttattgagt gcttactatg tgccaggcca tattctgagc attttgtatg ttcacctatt 65281 gattattcaa tccgtacaac agcctatgaa ataggtactc ctattatccc cattttacag 65341 atgaggaaat tgagaatctg gggattttat ctcattcaaa agcacagagc taagggttga 65401 aaccaggcag ttgatatcca gagcccactc ccttacctgc tactccaaac catgatttct 65461 tttgttgtta tgccccgaga ttccttgttc tacccaagtt tcctgtactc ttcttgccct 65521 cttcttcctg agacatcctt gaccatcaca gctctccact gagataactg tgtcctgggt 65581 tctgagacat gggggctgga agggacccca gggacagtga gcagtaggga gaggatgcag 65641 tgagaacaga ccctggatcc ccggtgcata ggcagggaga aagtggacaa aggaaaaaac 65701 aagcaaggca ggtggagcca tgcctaggta aagttgatcc ctaagccaca gttcccagaa 65761 gttcctgatt caaaagcaaa ttttctctaa ggtcaaaggg caaactgatt attctaaatt 65821 ctaaactgat tatttctaaa ttgagaaagc ttcagggaga gatcccaata ttcgaaggat 65881 aagagaaatg aggagtggaa gagataggtg agtaacagta acttaaatgt agactatata 65941 taatatataa tatatgtaga gtatatatat ataattacaa tatattatat atgtggaata EPI-109 987

66001 tatatattat ttatatatat ttatatattt tatatatata gatattttta tattttatat

66061 ataaatatag atatttttat attttatata taaatataga tatttttata tatattatat

66121 ataaatatat gtaaaatact gtgaaagaag aatagaatct tgagacctca aattcactat

66181 gccaaaggga aagttaagct tgggaaatga gtcatgcaaa aactgccttc cttttgttcc

66241 caaatacctg taatttcaca tgcttacttt atcttatata aaatgtagat gtactgagca

66301 tgagatccat gcataatttc cctctagtcc cttcttttta catgtaaagt gtagactcac

66361 tgagtgttac agagccttgc cacaatgtaa acacttgtct cattgccaac ccatctttcg

66421 tttattttct tcccctcctg cttgctcttt cccctctaaa gatggaagtt cccaaaactc

66481 tctttggaaa aagcgcaggt cacagatcct acagtgattt gtgtttcttt tacctgggac

66541 aaaataaacc tctaatctgt tgagatatgc ttcagttact ttttggttta caatatgtac

66601 atgtatgtat ataatttata tgtatataat atatgtactt gttttaacca gaggtatgtt

66661 attcaaaatc cattcatcct tacaattacc tgcattctcc cacagtattt tctgtgtccc

66721 tgcccccgag gttgtcactg caaatcaggt acatggatac tgggagctga tgggctcccc

66781 tctggctacc tgggctgctg aaggggccat agacagaccc agctttcctc tcgtggagag

66841 gccctgggcc agcgctgcgt gggagtggga ttacaaccag actatagctt cttcacctgc

66901 tttttcctat caggatttca taagaggcaa ttgcttgttt tttgagggtg ggggcaaatc

66961 agggggagtt gaagaggaaa ttgggtaaga tttgaatagt tgggcatgtt gaatattatg

67021 aatatcatct ccctcttcaa ataatccaaa atataccccc aagaaacagg ctgattagag

67081 gtgcttcaag gctccactga atctcccaag ctctgaagat gtagctagct gttaccggat

67141 tgccggtttt caagcctcgc ctcacatgga ccctcttggc agtttctcgc atgggggaag

67201 catccgctac atagatggga atgaaaagag gaaagaagac ggtgcaaact caggcacacc

67261 ccggtgtctg ccaccagtgc tatttaatct ctgaggtgtc acccttcctg gctttattgt

67321 ctcttcctgg aagtctcttg tcctctcctc cacacccttt aatcaggcat caaagacttt

67381 aaccagtttt gctgtgtgcc caggcccact cattctcact tttatggcaa agggagtggg

67441 agacagagag atagccagaa agaagagatt ggggacccca agacaaatgt tagaatttta

67501 accaaggcca ccctgtggac aggagattat tgggtttagt ggaaagcagc actggccaca

67561 accacacgtg gcaaaagcat ctatcgagga gtgaagttat atttggtgaa tgtgaccggg

67621 aagcaggggc agtggtgtcc tcctgccttc ctgaggcact ctgttccctt acctctgcga

67681 aggcttattt tacccctgag tgcttagttt tgaaagcctt agttccctct ctcccataaa

67741 aaagctctac tctgctaaca tctaagttac ctttgcagag tcttaggtag agggaggaaa

67801 tcccaataaa gattccaccc tatctgcaaa atacaaacat ggtatttctt gcattcccaa

67861 aattgtgaaa gaaaatgtgt atcaccacag tagagaatgg cattttttgt ttgatcaaaa

67921 cctaaatata tttgatgaaa atgtgtctgg ttctaagttt atttcccaga aagccatgtt

67981 tactcacttg gaatttatag acatcttata atatctgagt cgagtaggag ctccgggctc

68041 tacctcactc ttttctccca cacccagggg gaagtgtagg gttctcagac tttagaataa

68101 agaggaatca cctggacaac tcacctaaaa tgcacatctt caggtctcat actcagaggc

68161 tctgactcaa caggtctggg tggcgcccaa gaatttgggc tttaaatgag tatctcagat

68221 gattctaata cagaatgtgt aagatgacca gatcctatca cacttagatg tattggccta

68281 gggccaccta acttggagaa aatgttagta agaccccgtg gttggtgctc agctataggt

68341 accagaattt tgatcaaaa-t ttactatcat tgtgacactt ctcttcggaa ctggaaggcc

68401 agaaccccac ttgtaaagtg ctgggaaaat acaaggaaaa tttagggtga gtagcatttt

68461 gaattcttac acatggaaag taaatgtata agaattctta ccaataaaaa aaaagcaaga

68521 gagaatagct gctaaagaat taacacaaat atgtatatat tagttattct cttttctcct

68581 ctgattccag aggactttgt aattccacta attcttcttg agcttccagg atgatctgag

68641 acttgaattt ttcatgtgct ttttgcttcc tatttggcag catcttatct tgaagtttcc

68701 gctttctgct tggggaccta aaaactaact aatgggaatt tcttcaaaat gagcaaactc

68761 tggtgaattc ccaaagcgga agaaacaagt gaggatcggg ctggttaatt aagagaactt

68821 ttcctgaatg tagccagact gtttgccgac tgttgttaac atgagggaag aaatacccct

68881 ggattttaga agagcccctt gtttgttttc cttggccatt tgtgctgctt gttttgtaag

68941 tcagaaattt cctgaaggac tattattagc tttgttctca cgtcagaaaa cttctgctct

69001 ggccactttt aaacatataa cttggatttt actgtattag aaaatgtaac aattacagac

69061 agcactaaaa ggacaccaaa gggcaaagaa aatgggtaac ttttttttct tccccaaatc

69121 taaaataggt gattttggag aagtaggaga aaaacctgga ttttctagat ctctttagag

69181 ctcaacaact gatatagtta attatgtaag tctttgatat ttggaaatga ttggattaac

69241 cggataacaa tgaatattta aatacagtga tttggccagg agcagtggct catgcctgta

69301 atcccagcat ttggggaggc tgaggcgggt ggatcaccta aggccgggag ttccagacca

69361 gcctggccaa catggtgaaa ccccatctct actaaaaata caaaattagc caggcgtggt

69421 ggtgcaagac tgtaatccca gcaactcggg aggctgaggc aggagaattg cttgaacccg

69481 ggaggcagag gttgcagtga gccaagatca cgccattgca ctccagcctg ggcaacaaga

69541 gcgaaattcc atctcaataa ataaataaat aaatacagtg atttaacaca agagatttct

69601 atttcacact aatgagctct gtcactgggg caagcttctt tgcctcatta agtctcagat

69661 ttcccgagag cttatttatt tataccaaga gtgctttact accgtctctg ctagctgtga

69721 cataatatga caaaaggtat aaatatggga aaaggcacta atttatatca aagcgttctt

69781 cgtttttcct tgctgtgaag tttttagcta ataattcata agaatatacc atatttagag

69841 tgtttactat gcatgggcct ggcacttcac atacattgct tcttacaaat tttacaaagt

69901^' gaaaggtaga tattaatctc attttatgga ggacaagata gagatctgga gaggttacat

69961 aacttgccag tgttttttca gttaataaat ggtagggtgg agattcaatc tgtgttactc

70021 taaagtccgt gtccttttta ttggctccat gcctactcag atttaaatct cagcagggaa

70081 gtaaacctta gtttttacat gagaaaatgt tacagcagcc ttctcggctt cctttacccc

70141 catcccagtt tcacgagctt agtgccttag atcgggttcc tttagaagca gacctcgaaa

70201 taaggatgtg ggtgccagtc atttattgaa aagatgatcc caagaaagcc tagtaggaga

70261 gtgaggaagt gagatgggga aaggaagaaa ctccacaaga agtgtgttaa taagcaggtt

70321 accgctgtgg gcagccatgg ggctcagctg cactaacaaa ctctgtctag tacagaaaac

70381 ctcagggtct ccccaaggag gggcaagaag tctgcctagg gtatatatcc gccaactcag

70441 tcactggctg agagctgatc ctgggagggc atggttaatt cctctgcact ttcaagtgga EPI-109 988

70501 ttcctgtggt cagaaaaagc cctctacaat gaattccaga tgcttgtatt taaatctgac 70561 atgatctgaa tgctgtgttg ggacagggtg ggcgttatta gttttctgtc attactgtaa 70621 cagattacta caaacctgat ggctgcaaac aacacatatt tattatgtca tagtttgtgt 70681 gggtcagaag tacaggttag ctcaactagt ttctctgctc taggtttcac attgccaata 70741 tcaaggtgtc atccagttgg gctcttcttg ggaggcttgg ggatgaatcc actttcaagc 70801 tcattcagat tgttggcaga atccagttcc ttgtggttgc aggaccaagg tccctgttgc 70861 cttgctggct gttggccagg agtcattctt agcttctaga gactacctgt actctctgac 70921 tcgtgtctcc acttcacctt tcaaaccagc agcggctagt cgagtccctc tcttcaaatg 70981 tctccaactg tgccttcacc tcatttctcc tctgtgtacc atgtctgcct ctactgcttg 71041 taagggctca tgggattaca ttggatttat tcaatccagg ataatctcca tattttaagg 71101 ctagctgact agtgatctta attccatcta caaagtccct tccaatagta ctgtattagt 71161 ccattttcat gctactgata aagacatacc caagactggg caattcacaa aagaaagagg 71221 tttaattaga tttacagttc cacatggctg gggaagcctc acaatcatgg cagaagtcaa 71281 ggaagagcaa gtcatgtctt acatagatgg cagcaggcaa agagagagag cttgtgcagg 71341 gaactcctct ttttaaaacc atcagatctc ataatactta ttcactatca caagaacagc 71401 atgggaaagt cttgccccca tgattcaatt actcccacca ggtccctccc acaacatgca 71461 ggaattcaag atgagatttg tgtggggaca cagccaaacc atatcaagta cctagattca 71521 tgtttgatta aacaaccagg gagcagaaat cttcaggagt ggggggcatc tttagaattc 71581 tgcccaccaa ggctgggcgc ggtggctcac acctgtaatc ccagcacttt gggaggccaa 71641 ggtgggtgga tcatgaggtc aagagatcga gaccaccctg gccatggtga aaccccattt 71701 ctactaaaaa tacaaaaatt agccaggtat ggtggtgggc acctgtagtc ccagctactc 71761 aggaggctga ggtaggagaa tcacttgaac ccaggaagcg gaggttgcag tgagccaaga 71821 ttgcgccgct gcactccagc ctgggagaca gagcaagact gtctcaaaaa aaaagaattc 71881 tgcccatcat agtaggctgt cctacagaga cataacccag gaattaggtg aatggctaac 71941 ctaaattagc actgtgatgt gttttctgac ttggtcctta tagctcctct gcttagatgt 72001 ggaactaatc catgaatgca agggtttgtc tagagtttta agtgggagtt aaatatccaa 72061 agtacaggag atattatggg tgcctcatcc atgtcccctt ggcatttatc tttcttggat 72121 aacccaactc tattagtttt tatatctcac ttgttcctat actctgtgaa ctgatgtccc 72181 ataaatagac atttcatttt gccagtcttc ttgaacaata attacgatta ttaatctagc 72241 agttatcatt aattggccac ttcacattag acacagcact taggacttaa gaataccatg 72301 tcatttgatc atcataatat ggtcaggaat taagtattgc tatccaaatt ttacaaagaa 72361 ggcactgagg gttagagttt aaataacttg cttaagatgt catagcctgt aagtgacaaa 72421 actaggactc aaatacaggt ccatctgact ccaaagtcta tgttcttggc taccacactg 72481 cctctcctac aagtgacctg tggttttact actatattca cactctacta actttaccat 72541 ctcccatgag tctgtctaga ggagggcaca cacagcacag aaaacacatg aatgcaaaat 72601 aaggaagggc ctacttacta cacagagcca ttctaatacc tgatgtttgc tctaatccag 72661 ttttactatt aattagttgc tggtgcccaa gtttttactg agaaatgggg ataattttgg 72721 aagtcataat gatgccttct tctcataggg tattttattt gttgttgtat ctccaggccc 72781 caacacagcc tggcttttag taaatgatca aaaatacctg ttgaatgaat aaatggagtc 72841 acctgaaaca tgttaaacat ttgttcatgt gtcctaatcg tggatttcag gatagtaagc 72901 atcctaaaag gaaagcatgc acactgttct tgctacatta atttctcaca atataaaaaa 72961 agaaaagcat ctgaaaaaag ctgccagccg ctgtgtctcc taatatcaaa ctgagcacag 73021 atatggagaa gctaagggag agggatgatg ggccatgcct ctaacctcat catggcaaaa 73081 gtcctggggg tcagacccga ggagagcagg aagtgtcttt tgagggatac atttccacag 73141 tggaaataat gagacttaaa taaatattat atacacagtt caactgtttt tatgtgtaaa 73201 ggtagtaggt tttcacagta aggaagcact tctttttttt tttgtttgag acagagtctc 73261 gctctgtctc ccagcctgga gtacagtggt gctatctcgg ctcactgcaa tctctgcctc 73321 ctggattcaa gtgattctcc tgcctcagcc tcccgagtag ctgggacaac aggtgtgtgc 73381 cattacacct ggctaatttt tgtattttta gcagagatgc ggtttcacca tgttggccag 73441 gctgatctcg aactcctgac ctcaggtgtt ctgcccgcct ctgcctccca atgtgctggg 73501 attacaggca tgagccactg cactcaccaa gcacttctac tgatagcatt tacaaaccct 73561 tcttagaata tttaaaaatt ctaagagaag agtaaattga gccttcccaa ctaatactag 73621 gaggttataa ccttcatacc aaaactggac aatgcttgca caaaagaagg aagccaatga 73681 ggccacctag aaggaagact gggcattggg cccagtgagt cctggaaacc tcatctgtgc 73741 cagccacccc ggcatggcct gtatgagtgg atgagggtga cttgtccaca gacaatagcc 73801 atctagctgt gataaaggag tcaaggtagt cagctgcatc tctttcacct gtttgccaat 73861 gttacacagg ttgaaaagct aaggtttatg taaagcaagc atcaaagatg atgaaatgat 73921 caacctgaca atgagtacta tgctgcattg tccagaaagg aactgtggaa gattttgggc 73981 tgaatttcaa aacagaattt cctcactctc tggatgttgg cttacttggc ctttgatgtt 74041 cagaggtggt gcctttgtgt tgttgaacaa tgttgatttt ggagagaaaa cagagttgaa 74101 aaacccacaa gtcattccct ggggagtatt accggaatac agaggataat ttcagcaagc 74161 cagcaaggcc tcatctctgc ttctaataga taggaagaaa ggaagagagg aacaatactt 74221 ttttaagaag ctcagcttta tcgccttatc tcatagaaag atgcctccag tctgtctggc 74281 taaaggtaat tggcatggga aagtctttat ctgtgattct aacaagtgga atgtttccct 74341 tcattaagag agccttgtct ggcttgggga aatgaaacac tttctccgat atgagtgggc 74401' tgtaacccct gctactaaat actcagaaga aataaggcgg ttgtggagca gtcaggaatg 74461 agtcacttgc ctccctggaa tattcagaaa actgaatcaa aagtacattc ttctgggttt 74521 tcttagtcta atagactaag ggtctctact ttgttaaatt tctgggaaac agcatagaat 74581 gggagaaaaa actggtcact gtagtcatgc aaatctgcaa aacaaacaaa aaagtctggg 74641 tattgctgct aactagctat gtgaccttaa gcaaggtatt aactctctct gaatttcagg 74701 ttcttcatct gttaaatagc atatctgtaa aatgggaatt attttcatat cataatgctg 74761 tagctttaaa aaataaaata aaatggatga gataatcaga attaaagagc ctgggatata 74821 tagttaatat atagcagcat gtaaagatcc tgttagaaat gctaatttta cagttaacca 74881 tttggagatg atccgccaaa gctgctagtg tagaggcaac tgagaatttg cctgtccttc 74941 agaatatgaa taaataactg tcaatgatgt ctcaagccta gaaaaaccta tccatctgga EPI-109 989

75001 tgggtgggaa atttctaggc tagtattgag aagcccattt cttgggaaat aggtcctgga 75061 ctgagtgaag gaaaagaaac agtaaaaccc atggtaaagc agcaaggctc tctagaggct 75121 ctggagagga tgaattgaat tctagaagat gaagtaggga agacgcttta ccttcttgtg 75181 aaatggattc aaagattcaa agaccttcgg gaatctccaa ttgtataaat ggcaccatag 75241 ctgtatgttc catggaacac tacttcccag agatgcccag tgaaaaaaga atgccacagt 75301 caaataagtt tggaaacact ccattatgtg gccacctcct tgaagactct aatgcacatt 75361 agcatgttaa acagtcttga gaagtcctgc agagcagaaa ttgcttcaca tctgctaagc 75421 cggcagtttc ccaatatact tgattatgga tagttttttc cttacaacac cattctctga 75481 tatgcttcca atgacatgaa ataaatatat atgcatgagg ttcttcatta gggcatactt 75541 tttaatagaa aatattgaga ataatctaaa tataaatgca cagcatttac cttttctgca 75601 taaactatat acaggcatac cttggagata ctatgggttt ggttcccaca atatctccaa 75661 aaccacattc ggttttatga ccactgccat aaaaccagcc acatgaattt tttggtttcc 75721 caatgtatat caaagttaca tttttactat accatagtct attatatata caatagcatt 75781 atatctaaaa aacaacgtaa acaccttaat ttaaggctgt ggctggtttg attttctacc 75841 cagaccacta aaactttctt catatcagca ataaggctgt ttcactttct tactattttt 75901 tgtgatagca cttttccttt ccttcaagaa tttttccttt ctattcacaa tttgtttgat 75961 acaagaggac tagattttag cttatctcag tttaaggtgt ttacattgtt agctaaaaat 76021 gctaatgatc atctgagact tcagcaagtc ataatctttt gctggtggaa ggtcttgcct 76081 cagtgttgat gtctgctgac tgggtggctt tggcaatttc ttaaagtaag acaacaatca 76141 agtttgacat atcaattgac ccttcctgtc ataaatgatt ttttttttct ctgtagcctg 76201 caatgctctt tgatagcatt ttacccacag tagaattttc aaaattggag tcaatccttt 76261 caaactctgg tgctgtttta tcaactaagt ttatggagta ttagaaatcc cttgttgtca 76321 tttcaacaat gttcacacca tcttccccag gagtatattc tacctcaaga aaccactttc 76381 tttgctcatc tataagaagc agctcctcat ccactaaagt tttatcctga gattgcaaca 76441 attcagttac atcttcaggc tctacttcta attctagttc tcttgctgtt tctatctcat 76501 ttgtgcttac tttctccgct gaagtcttga accccttaaa gtcactcatg agggttggaa 76561 tcaacttctt acaaactcct gttgatgttg atattttgac ctgctcccat gattcatggg 76621 tattcttaat ggcatctaga atggtgaacg ttttcagaag gttttcagtt ggctttgccc 76681 ggatccatca gacgaatccc tatctatgga agctatagat ttataaaatg tatttctttt 76741 tttgtggggg catagcgtct caccctgtca cccaacctgg aatgcagtgg cacagtcata 76801 actcactgaa gactcaaact cctgggctca agtgattctt ccaccttggc ctcccaaaac 76861 actggattac aagcttgagc cactgtgtct agcccaaaat gtatatcata actaatgagg 76921 cttgaaagtc aaagtgactc cttgatccat gggctacaga atggacgctg ggttaccaga 76981 catgaaaaca atactcatct cctcatacat ctccttcaga gctcctgggt gagcaggccc 77041 attgtcaaat gagcagtagt atcttgaaag aaattttttt tctgagcagt agatctccac 77101 agtggactta aaatagtcag taaactatgc tgtaaacaga agtgctgtca tccaagctct 77161 gtttttccac tgatagggca aaagcagagt agatttggca taattctcta gggccttagg 77221 atttttggaa tggcaaattg agcattggct tcaacttttt tttttttttt tttttttgag 77281 acagagtctt ggtctgtcac ccaggctgga gtgcagtggt gcaatctcgg cccactgcaa 77341 gctctgcctc ctaggttcac accattctcc tgcctctgcc tcctgagtag ctgggactac 77401 aggcacccgc caccatgccc ggctaatttt ttgtatttta gtacagacgg ggtttcgcca 77461 tgttagccag gatggtctcg atctcctgac ctcgtgatcc acccgcctcg gcctcccaaa 77521 gtgctgggat tacaggcgtg agccacagcg cccagcctgt cttcaactta aagtcgccag 77581 ctgtgttagc ctctaataag agagtctgcc tgtcctttca agctttgaag ccaggcatca 77641 ttctcttctc tagctatgaa aatcttagat agcatcttct cccaatagga agccattttt 77701 tatgccctaa aaatctgtcg tttggtgtag ccaccttcat cattgatctt acctagatcc 77761 gctggataac ttaccacagt gtctacatca ttacttctgc ttcaccttgc acttttatgt 77821 tatggggatg gctcctttcc tctaacctca taaactaacc tccactagcc tcacattctt 77881 cttttacagc ttcctcgcct ctctcagagt tcacagaatt gaagaatgtt gggccttgga 77941 ttacactttg gtttaaggga atgctgtggc tggtttgatt ttctatccag aacactaaaa 78001 ctttcttcat atcagcaata agactgtttc actttcttac tattttttgt gatagcactt 78061 ttcctttcct tcaagaattt ttcctttcta ttcacaattt gaccgtttga tatgagaggc 78121 ctagatttta gccaatctca gtttacacca tgcctttttc actaagcttc atcattttag 78181 ctttttattt aaagtaagat gtgtgaccct tcctttcatt tgaacactta catgatgatg 78241 cctggcttca aagcttgaaa ggacaggcag actctcttat taggggctaa cacagctggc 78301 gacttttaag ttgaagccaa tgctcaattt gccattagaa gccattgtag ggttaattaa 78361 tttgcctaat tttaatatta tggtgtctca gggaataagg aggcctgagt agagggaggg 78421 agatggggaa acagccagtc atcagagcac acacaacatt tatcaattaa gtttatcacc 78481 ttgagggcac aggtcatgat acttcaaaac aattacaata ataaaataaa aaatcattga 78541 tcgcagatca ccataacaga tataatgata atgaaaaatt tgaagtattg tgagaattac 78601 caaaacgtga cacacagaca caaagtgagc acatgtcatt ggaaaagtgg tgctgataga 78661 cttacttcat gcagggttgc cacaaatact caatctgtaa aaaattcaat tatctacata 78721 gtaccataaa aacaaggtat acctgtttat ataatcaaga ccaacagaac cctagagaaa 78781 atagctcact ccctagctcg gagacattct aaccaacata cacttacctt tctttttgct 78841 gtgtacagaa ttcaaatccc tgtctcagca aaattgcaaa gtatcaaatg tcatgtccat 78901 ctaatactca aaactgcaaa tgttaagtct tgtaagccca gagaccactg tatatacaag 78961 tgttgctata agcattagtt cttctccaaa gaaaatagtc cacttggtag aaacaaacaa 79021 aaagaaaaaa aaagaaagaa aaaacatttt ttacaagaag attcagtctc ttacctacat 79081 aagcaaaaat atgagatgtt ctcttatcat ttttccatct atcttataat ctttggtgct 79141 gacttagaca ctcattttcc tttttgtacg tgaccatgta aaagttcaag tcaagaaaaa 79201 cttgttttga catttgtttt gctgagtgat gggtccctaa aagaaatttg gctttgcttt 79261 tgaaaagttc agcatgatat tgtgtgaatt tttcatggct aatgattttt agaacagttg 79321 tgatgtgttt aggtgtttta agaatatgaa gcattcagtg gtttaagttg gttgttataa 79381 aatgaaagaa tatgaaggaa agccttcttg tcttagaaca cactgattca caaataagca 79441 gcttctctca aaatgttgta attacaaaaa ttccaaggca aatataataa actccttgtc EPI-109 990

79501 ggtgctatgt ctagaaactt aacagcccca aagaaagtcc tgacaaggca aaaaatatat 79561 atatatatac aaattgtgga agcagggtgt tgaaagaaga ataaagacta tataaggaca 79621 aactgtttaa aagggagggt atccttgaaa gcttgacact tgactctttt gacgaggctg 79681 agggaaaaca ctcagtttca tagattgctg gtacggatgt aaaatagtga catccctata 79741 gagaggaatt tggcaatatc tagcaaaagt gcttatgcat ttattctttg acctagtaat 79801 cccgcttcta ggattagtgg tgaagataca cctcaacaat aaaaatatat atacattagg 79861 ttattagtta tggtttaatt tttaatagca aaatatttaa aacaacctac atgaacaaat 79921 aggagactta ctgaataaac tatggtatat ctgtacaata aagtgcaatt cacttatgtt 79981 gttaatttgt tccaaaaatc cagagccaaa gagtatttgt tatgctctct ttagtataag 80041 aaaggggaaa taagatatgt gtgcatctgt ttatttttgt gaaaataagt acagaaagga 80101 taagtaagaa actagtaaaa ctagttatct cctagtgtta gtagaaatag aatgaaagtg 80161 aattaggctt ctttgagtat atgtttatat atagttttga cttttgaatt atgtttatgt 80221 ttacatagtc aaaaatataa attaatcaac agaaataaca aaaaaagaag aaatcacaag 80281 ctttaaaatt taatacaaac agaaataatt gaatctaaca gtatatcaaa gtgataacgt 80341 aaactcagaa gaaaaaaaca taatccaaca taccagtgga acacaatatt ctaactgtat 80401 acattcagtg gttatagtct aaggacaaga aaaattgcaa aaatatcttg aactttagct 80461 tgtaggattt ttattggtag caatactaat gtactaattc tgaaattaat gttcgtgtat 80521 tatagaattg agtaaatgaa taaatatgtt gatgttattg ggaactaaaa ttatcattct 80581 gggagtagag aaatataaat atggacttgg caaatgaaac aaagacctgc agagagataa 80641 ccatataaac tcattatttt aaaaattata agtgtcctag ctctgttact gaaaaggcct 80701 agattcaatc ttatcttgat agacaggagg gcaccccttt ctcagaacat ggtttccaaa 80761 tgccattctc cattaaaagg aacaaggtct tcttggagaa aagactgatt ctaggtctgg 80821 attaggtaaa gtacaacgtt agtctggaat ttcttgctga atcagaagta agaaagtgct 80881 caaaaacatg ggaacatgtc acaaacacac gtgaggcaac ttgaatcctc actggccata 80941 tttaggacaa tcgagcatca aaaaaaaaaa aaatgttgag aataatggat tctaacactt 81001 aaaacaaaaa ataatccata gcccacagaa ggggaagaga gggggagctc ttatttacag 81061 atgaatatca aatagcaaag acagaagaaa tgacagaatt agagaaacat cattttgcaa 81121 aacaccactg taataatcaa ttcaggcaag tattattaat ggatgtatta ctattgcgta 81181 aaaccagttg gggaacagga tattcataca gtctgaaggt gtcaccctaa acataactta 81241 ttacaagtgg aaaatggtgc ctttacaatg aagaaatcta gcagaaacca tcttaatcta 81301 gtgatcaaac ttagtatcac caataatgga tcatactgag tcatgtgtct cctaatatga 81361 tgcaccagga aggatgcaac gtcatgaacg ttgtattctt ttgtattcaa cagaccaccc 81421 agggtaaagg cagctttctc acttactaat cagaattgtt ggttttaatt cattttggat 81481 tttaagattt cttactttct tgtcagctca gaaatttatt taagatgatt tttatctttt 81541 attcaatact ttagcttgga gaaccattca gagtttctaa ctcattgtat tgccaaaaat 81601 agaaaacagc atggtttctt ttgaaaatgt ctaactttaa agttacttgt gtgtgtcact 81661 cagattcaca tagctttttt gcctagtaat gtagtatcat gtggcaaggc tataaaaatg 81721 tttacaatct tttatttaat atgactcttg agagtttatt ctaaggaaat aattgaatag 81781 taacaaaaca ctattaacac aaagcatagc aatttgattt gggcaaccaa acactggaaa 81841 caacctaaat gtccattaca ggaatcattt atgaagcaaa cactaaaata tttattgtga 81901 agattatgag aacatagaag acagttatga gagtaaattt gaaaacctga acacaaaact 81961 tacatatact ccaattgtaa cttataaaaa atacgtgcat ataaggataa aacagtacaa 82021 acaaaaaaat agttgcgtta gattggtaga attatggctc cttttgctgt cttaattttt 82081 tccttttaca ttttgataca ttattttaat tttaatttta aaattcaaaa gaatttgcca 82141 ctcatctttg ccacttcaag gaaaaaagaa atgtgttcga ttattctgtt cttagtatag 82201 ttttggcaat ttcctcacgt gtaaaaagag aatactatta ataatttcag tatctataag 82261 acaatataaa attaaagaat ctagcccagt aactggtaca tggaacgtaa ttaataaatc 82321 attatggact ttttttctca cacccaagta gggaggaatc agtggtcccc tagaggccca 82381 gtgtagaggt ggcagcacca atccctaggg gagaagatct tggtgatgat aattcctgag 82441 cagacagtta gctgagaatt caagagcaga aaagtaagaa agaaacaact tcttgctaac 82501 acctttccac ccacgtttcc ctgttctgtt gtactctgct taccctttca tggatggagg 82561 cagaggaaag agaaccaagt ttgctcttag tcattcacta tgttgtttaa tctgccttcc 82621 atctttctta tcagttcaaa ttagaatgta gacctgaatt taaatccccg ttctgtcagt 82681 tataatgtga ccctagacaa aacacattct ctgaacctca gagaacattc ttcatttgta 82741 gaatgggaag attaatctat attccacttg gatggcaagt cttttataaa ctttataacc 82801 taaacatgtg tgagttgcta gtatcattat gttggtaaag ttattctgag atatgataac 82861 agaactgttt tgtctaactc cactagcatg gttcaggttt agagagtgtg gaattaaaag 82921 gctttatcct caaatatgac ttaaatccga tttttctcat ccactttcct ccacaaacaa 82981 atcctcagga aatgacaaac tttacatggt taaacatcag ttttgtttag tctttgacat 83041 ccacatggtt aaatcataca tttgaaaact gcttatattt gtgttgtcta tgtctaaatt 83101 gaaaagactt attgaggaat agaagactac acatttttca gcaaacactg cacgttttgc 83161 agaatttccc caggcaccag tctccaggaa tttattggct actaacaata ctaagatatg 83221 gatgaatgag gaaatcaaaa tggagatctt gcaagttttg tgagaatggg tgaatggtcc 83281 aaatgaagag ataagttgt aaatattagt acaagtaaaa attatttaca atgaaagaca 83341 ttttgtcaat agctatgaga attttaccat tgacccagaa attccatttc tttcttcaga 83401 aatacccacg taggtataca tataaaaagt tattcattac agtatcgttt ttcataggaa 83461 aaagttttaa aaatcagaag ctatctaaac tatggtatat ctaggtcata gaaatcaaat 83521 gactaaaaat gttaatataa gcatatgttt ttaaattaac ttggcttggg tcttcagcaa 83581 aattggcttc ttaacattgc actccagagt tagacttacc cactcagtca cttatcatgc 83641 aggagcagac tcctaatacc acatatcata gagcagagta ggacacaggt tctctgcagg 83701 caggcaaatc ccaaagagaa gggaggaaag ggctgagaca ctgcatggtc aatttcttct 83761 gaactctgca atgtacggag gtggacagtg tccacaaaga ttgctcccct ggacccacca 83821 tcataataac acaacggctt tgttttgttt ttgtttttgt tttttgacac ggagttttgc 83881 tcttgttgtc caggctggag tgcaatggtg tgatctcgac tcaccacaac ctccacttcc 83941 tgggttcaag tgattctcct gcctcagcct cctgagtgga tgggattaca ggcatgcacc EPI-109 991

84001 accatgccca gctaattt g tatttttagt agagacgagg tttctccacg ttggccaggc 84061 tggtctcaaa ctcttaacct caggtgatcc acccgtcttg gcctcccaaa gtgctgcgat 84121 tacaggtgtg agccaccgcg cccagcccac aatggccttt tgtttacatc tctagtgcag 84181 cactcatttc atgttctttc aagaagaata catatttcat ctttttattt tatacagcaa 84241 ttagcacagt gcctggcata aggaaaatga tcattaaaag ctgggtgaaa aacctaataa 84301 agctactgag gataggaact gcagaccagc atggaaagaa aactatgagc cagatattga 84361 catcatcctg aaaggcagaa gatttagtat aggcaagaag tatgcttttg gaatatagaa 84421 aatctggatt atgataagaa aagaatcata tttgtcttat cttacctact cacttctcag 84481 ttccacatgt ttctgaggct gtttgtcctt actttctttt ctgttttatc cactctttct 84541 gttctttaga ttggatcatt cctattgagc tgacatcaag ttaactgacc ttttattttg 84601 tccaaactgc tgttaaatgc atccagtgaa tttttaactt tatatagtat atcttttagt 84661 cctagaattt ccacatgagt tttttaagtt tccatttctc tgctgagatc tcctatttgt 84721 tcattcatta tgaccatatt tttctctaca ttattgagca taattataac agctcttcta 84781 aaattcttgt ctgcacattc taacacctga attattctgg ggtcagtctc tgttacattg 84841 ccttattaca aaaacagtat aagtcacatt gccttgtttc ttaatatgca aaatgatttt 84901 tgattgcaga ctagacattt tgaattaaac attatagaga ttctggattc tcgagagagt 84961 attgacttgt tttttccatc aggcaggtaa cttgactgga ctcaaactcc aaactctagg 85021 tcctctgtaa tgggcaactg cagtaatctt tgtttagttc tttaagactt attggccagg 85081 cacgggggct catgcctgca atcccagcac tgtgggaggc caaggtggga ggatcacctg 85141 aggtcaggag ttcgagacca gcctggccca catggtgaaa ccctgcctct actaaaaata 85201 caaaaattag ccgggtgtgg tggtgggcgc ctgtagtccc agctactcag aaggctaagg 85261 cagaagaatc acttgaacct ggaaggcaga ggttgcagtg agccgagatt gtgccactat 85321 actccagcct gggtgacaaa agcgagactc cctctcaaaa aaaaatttat tggcactgct 85381 tggcatctgc tatgaataca tgaagttcat gggtcagcta tagatctggg cacgttatac 85441 acagaatttg ggtctccctt tctctggatt tctccttttc tggatttctt ttctcatttt 85501 ccagcagctg tggttgccct aaactcggtc ctctgtttct ttacggcagt aagatttggg 85561 aacttttagg ttttacctgc ctctcagaca aaataaaaaa taattttcat cttgatgcta 85621 ctcctttctt ccagatgtag acacctctct aatttccagt tgctttttat tgctctccag 85681 agtctaaaga ttatcattgt tttctgtggg agagttggtc tgataaaaac tactccccca 85741 aaactggaag ctggaagctt gtaattatga atagactttg agtagtattc ttctttggaa 85801 aaggatttta actactccct atgtacttct ttatttcctg tttttctcat ccgtaatctt 85861 tttattttca tacttcctaa gtcagacaat tttcctactt gaagattcag tgactgctat 85921 caaatgaccc ccatattact aaatacaata tccccaactg catttataaa aagaaaattt 85981 actgtttatt agtaaacaat gttgtagaat agtaaaatat tgctgggctt tggagccaga 86041 taatcaaggt tagaatccca gattctaact tactagctgg tgtattagtc ctttctcatg 86101 ctgctaataa agacataccc cagactggga gactgggtaa tttatgaaga aaagaggttt 86161 aattgactca cagttcagca tggctgggga ggccttagga aacttacagt catggtggca 86221 gcaaggagaa gttccaagca aagagggaaa agccccttat aaaaccatct gatcttatga 86281 gaactcactc actatcacga gaacagcatg agggtaactg ccctcacgtt taattacctt 86341 ccaccagttc ccccccatga cacatgggga ttatgaaagc tataattcaa gatgagattt 86401 gggtggagaa atagccaaac catataattc cacccctggc ccctctcaaa tctcatgtcc 86461 tcacatttca aaactcaatc atgccctccc aactgtcccc caaggtctta actcattcca 86521 gcattaagtc aaaaatccaa gttcaaagtc tcatctgaga caaggcaagt cccttctgcc 86581 tatgagccta taaaatcaaa agcatgttag ttacttccta gatacagtgg gggtacaggc 86641 gttgggtaaa tacactgatt ccaaatggga gaaattgcca aaacaaaaga gttacagacc 86701 ccatgcaagt ccaaaaccca atagggcagt cattaacatt aaagttccaa aatgatctcc 86761 tttgacttca tgtctcacat ccaggtcaca ctgatgcaag aggtgggctt ccaatggcct 86821 tgggcagctc tgcccctgtg gctttgcagg gtatagcctg cttcctgttt gctttttcac 86881 aggctgacat tgagtgtctg tggcttttcc atgagtatgg tgcaagctgt tggtggattt 86941 accattctgg ggtctgggcc aggtgcagtg gctcatgcct gtaatcccag cactttggga 87001 ggctgaggtg ggggatcaca aggtcaggag atcgagacca tcctggctaa cacggtaaaa 87061 cccagtctct gcttaaaaaa tacaaaaaat tagccaggcg tggtggtggg tgcctgtagt 87121 cccagatact tgggaggctg aggcaggaga atggcgtgaa cccaggaggt ggagcttgca 87181 gcgagctgag attgtgccac tgcactccag cctgggcgac agagcaagac tccatcaaaa 87241 aaaaaaacaa aaaaaccatt ctggggtctg gagaatggta gcccttacag caccaccagg 87301 cagtgcccca gtggggactc tgtgtggggg ctctgacccc acatttccct tctgcacggc 87361 cctagtagag gttctccatg agggttctac ccctgcagca aacttctgcc tggacatcca 87421 ggcatttcca tacatcctcg gaaatctaag ccgcggaggt tcccaaactt caattcttga 87481 ctcctgtgca cccacaggct caataccaca tgtaagccac caatgcttgg tcagggcttg 87541 aaccctctga agcaatggcc tgagctgtac gttgacacct tttagcctag acatctagga 87601 cacagggcac catgacccga agcttcataa agtgggaggg ccttgggact agctgaggaa 87661 accatttttc catcctaggc ctccaggcct gtgatgggaa gggcagccat gaaggtgcct 87721 gacatgccct ggagacgttt tccccattgt cttggtaact aacattcagc tccgtgtgca 87781 gcaccaactt acttatgcaa atttctgtca ctggtttgaa tttctcccca gaaaacagga 87841 tttttctttt ctattgcatc atcatgctgc aaattttcaa acttttatgc tatgcttcct 87901 gttgaagact ttgcggctta gaaatttctt cccccagata cccaaaatta tctctctcaa 87961 gttcaaagtt ccacagatat ctaggggaca aaatgttgcc agtctctttg catagcaaga 88021 gtgaccttta ctccagttcc caacaagttt ctcatctcca tatgagacca tctcagcttg 88081 gacttagttg tccatgttac tatcaacatt ttggtcaaag ccattcaaca agtctctatg 88141 aagtttcaaa cttccccatg ttttcctgtc ttctaatagc cctccaaatt tttccaacct 88201 ctgtctgtta cccagttcta aagtcacttc tacatttttg ggtatcttta cagcagtggc 88261 actccccatg gtactaattt actgtattag tctgttctca tgctgctaat aaagacttac 88321 tcgagactgg gtaatttata aagaacagag gttcaactgg ctcacagttc agcatggctg 88381 ggaggcctca ggaaacttac aaacatggtg gcagcaaaga gaagttccaa gcaaagaggg 88441 aaaagcccct tataaaacca tcagatcttg tgagaattca ctatcatgaa aatagcatga EPI-109 992

88501 gggtaactgc ccccatgatt aatttacctc ccacagggtc cctcccatga caggtgggga 88561 ttatgggaac tacaattcaa gatgagattt gggtggggac acagccatac catgccagct 88621 agagagcctt aagaaagtca cctaatctcc acaaataaaa ggtttcctat ttgttcaaca 88681 aaaataatga cacccctttt atgggatttc tgtgaggaca aatgataact aacatagcct 88741 tgcatagtgt ctggcacaaa atagctactc aaaaaataat agaaacaaca tttaaaaaat 88801 gtagacttta ttttttagag ttttatgtac aaagcaaaat tgagcagaat gtacagagag 88861 tttccgtata gcactcccta cccccaagca cagatagcct cccccagtat cagcatcccg 88921 caccagagtg gtacatttat tataactgat gaatctatat tgacgtgtca ttttcatcca 88981 aaatccatag tttatattag ggatgcctct tggtgttgta ccttctatgg gttttgacaa 89041 atgtataatg acatgtattc accattacag tatcataaag aatagtttca ctgtcctaaa 89101 aatctttgat cttcttccta ttcatcactc cctccccatt aatccctgac aactactgct 89161 aattttcctg tctccattgt tttgtctttt cctgaatgtc atatagttta aatatacagt 89221 atgtaggatt ttcaaactgg tttatttcac ttagtaatat gcatttgatg ttcttccata 89281 tcttttcaaa gcttcatagt tcaatattta tagaattgaa taatattcca ttgtctggat 89341 gtactacagt ttatgtattc attcacctat caaagaacac cttggttgct tccaagtttc 89401 aacaatcatg agtaaagctg ctataaacat ctatgtacat gtttttttgt gaattgaaca 89461 ttttcagctt ttttagctcc attcctagga gtgcaattgc tggattgtat gataagggta 89521 tgtttagtgt tgtaagaaac tgccacgctc ttcctaactg gatgtactgt tttgcattct 89581 caccagcaat gaaagagttc ctgttgctcc acatactcac cagcatttgg tgtcgtcaat 89641 gttttgagca atagcatttt gatctaactt ttcctaggta ttctttttga aggaaataat 89701 atgacagata atagagaaag gatatacgag gacagttctg tcctttattt atagtccatc 89761 atttaatgaa ggactctgtc cacacttggt atttttaact ctgatcctcc tctcccatga 89821 actctgacaa tctcctaaat ccctgttgct ggcacacatg gttgtgtatc aggccccctg 89881 tggtctgtct gaagcatggc tttttttttt tttttttttt tttttttgag acggagtctc 89941 gctctgtcgc ccaggctgga gtgcagtggc gcgatctcgg ctcactgcaa gctccgcctc 90001 ccgggttcac gccattctcc tgcctcagcc tcccgagtag ctgggactac aggcgcccgc 90061 caccacgcct ggctaatttt ttgtattttt agtagaggcg gggtttcact gtgttagcca 90121 ggatggtctc gatctcctga ccttgtgatc cgcccgcctc tgcctcccaa agtgctggga 90181 ttacaggcgt gagccaccgc gcccggcctt tttttttttt tttttttttt tttgagatgg 90241 agtctgtcac tctgtcaccc aggctggtgc agtgatgcaa tcttggctca ctacaacctc 90301 catctttcag gttcaagtga ttctgccacc tcagcctccc aagtacctgg gattacaggt 90361 gcccgccacc acacccagct atttttttgt atttttagta gagacgtagt ttcaccatgt 90421 tggccaggct ggtctcattc ctgaccttga gtgatccacc tgccttggcc tcccaaagtg 90481 ctgggattac aggcatgggt catcacatgt ggcctgaagc atgactgttg ctttaatcat 90541 atgaaatact gctctgtatt gttatctatt tgaaatgcca cacctcctga gctaaattgc 90601 aagcttttat ggagcacaaa ccatatttat atatattagc atgataccat gacacatatc 90661 aaaagctgtt atatattgtt acgtgaattg attctttctc agttaagagg acctctgtag 90721 tagcactttc ataccgttaa tttttcattt tgtgcccagc ccctactctg tgaaaaatga 90781 aatgaatcct gttatcattt ccctcccagg ccttttctcc ttgtggacaa tgtgtggctc 90841 aagagaaaat tcagtcagta aatttgttca gtgcacaaac tctttatcac ctctcactgt 90901 tctcaagtga gatagaacag aacatccatc cagtgtctta caaattgtct ggtatatagt 90961 aggcactcaa taaatgtttt ttgaataaat gcatacatga atcctattcc tatatatagt 91021 atggtagaca gatcattgat acccaaagat gcccaaatgc tgatccccag aacttgtgaa 91081 tatgttacat ttcatgtcaa aagggacttt gctaatgtga ttaaggattc agacccttgg 91141 attgtaagat tatcccggat taaccagggc caatctaatc acatgagacc ttaaaaaagc 91201 agaaaacatt tcccagctgg gttagagaga gatgagacag agtaaaaagg aaagagattc 91261 agggcatgaa aatgactcta cccactgttg ctggctttga agatagagga actaggccac 91321 aaaacaagga gtatgagtgg ccttaagaaa taggaaaaag ccctcatctg acagccagct 91381 agaaagcagt cctctgacca caagaaattg gattctgcca accactcaaa tgagcaagga 91441 aatggattct cccctagaac ctccagaaag gaacacagct ctgtaatgcc ttgattttag 91501 ccaggtgaga cctgtttcag acttttgacc tatggaaata taagataata aagttttatt 91561 gtatgctgct aaatttgcgg tagtttatta ctgaagcaat ggaaagccaa tacagacaga 91621 atatacagag agaaagagaa tgagttcttt cctgataatt tgtaaatatt tgggtcttca 91681 ctggacaagc ttcacagagg attcactggt tccctagcaa accagcatgt ccagtcctgc 91741 agcctccctt tcttaggccc agcatatgtc agctgtgtgc atagaaaaat caaagcagga 91801 ccctgagtag ttggaaagaa aagatggttg gaaatgggtt gcacttcaag tgaggaaaca 91861 agaggtagga gaccggcatc tctttctcat atgtcccagg ctgactcttg tgagttgttt 91921 tcccttggag gctatcgatg acagtcacag taacctgatg gaacctggat catgatgaaa 91981 gaagtaagtg tcaatggctc cgacttccaa ggactctgat gtcccacagc actagctaaa 92041 caaagccagt tggaaatgag cttaaatggg gaatttcctg aatatattcc ctattgttag 92101 gaagccaggt tggcttcctt gcctacaatt atgccaagca gtcacactat agagtcccta 92161 gggacatgat attaagtgat tcttttaaca caaacaactt aataatcatt tatactaata 92221 gcaaaacggc caacggctga tattccactt gaagtagaat tggctatcca actggaagag 92281 aagacaggaa gacgtgatct ccagggagcc actaaaagga ttggcacctg cctctggatt 92341 ccccttttcc ttatattacc tctcagcact ggcaggcctt tatttcagga tacagtttca 92401 caagtattat gtcacgtctc tgagaattat gttggtagat atttgctcct ctggccagaa 92461 agacctagtt tggagtctgg agtcatgaag gtgacataca tgtagctagt gacataagtg 92521 tagctagtaa aaatagtgag taatggccct gaaattctat tgaatgccca aagtgctgac 92581 caggaacaag catgctctag cttatctcac aaggaacttg acaattttct tcaaaaatcc 92641 tagtagctaa gatttcttag taacaaagcc actaaggcac aattatgatt aacttgaccc 92701 ttaggtgact tttaaggact attctataaa atattacaac taatagtgga tccaagccag 92761 cacactctgc tatataagat taattgacag tgtccacact ggtaaaataa gttgtttcat 92821 aaatacatta gaattcattt gcactttcta cacagcccca agtccagaac tttccccaga 92881 ataggtctat gttttgcaat ctgctactcc atacagagat ttgagttcac ttggcaattt 92941 agtgctgctt atatgtgacc agttagtctg ttttacttat ctatgcctta aacattacta EPI-109 993

93001 tacttactaa ctccaagatg cctggtctca acttgacaaa aataccccaa gttgggaaat 93061 ccttatgtga atatgtagat agtcacaatt gctggttgat gatgatctgt cttttcctgt 93121 atttgagaaa atggagataa aatggaccaa tccaaataat ggattaaaca tgggaatagg 93181 tgagagagag agaggaatac atggtggctc tcagtgtctg gcttaggcag taaacacttt 93241 cgttaataaa gacggaaaat aaaaaaggaa taattggtgt ctaggggaaa ataatgagct 93301 caagttttaa cactctgagt tcccggatgt gagacatcca ggcgcattta tccaagaggc 93361 agttggaagc aacgttccgg agcttaggag agaggcatga ccaaaagctg gtgggactgt 93421 gaaaaggtat ggccattctg gaaaactgtt tggcagtttc ttagaaaatt aaacatgtac 93481 taacaaccca gcaattgtac tcttgagcat ttgtcccaga taaatgaaaa aaaaaaaaag 93541 catttttttt acacaaaaac atatacatga aagttcatag aagtgttatt cataaaaaac 93601 tggaaaaaac tgagatgtct ttattgagtg aatgcttagg caaacggtgg tctatccata 93661 caatggaatt atgcttagca ataaagagaa aagaactatt gatacatgca ataacacaga 93721 tgaatctcaa aggaattaat gctgagtggg aaaaaaagca catctcaaaa tggtatatac 93781 tgtactattt tatttactta acattttaaa aatagcaaaa tcatagagat ggagaacaga 93841 ttaatgggta ctgtgttttg ggatggggag tgagaaaagg gtaaggtgta aatataaagg 93901 ggtagcacaa aagagccttg tggttgaagg attctatgtc ttggttgtag tcgtgattgc 93961 aggaatctac atgtgataaa attgtatggg tctacatacg catacacaca agagcatata 94021 aaactggtga catgtgaaga agctccgcac attgtgccaa catcagtatc ctagtttcaa 94081 tatcagacta cagttataca aaacattgtc attgagggaa actgggtaaa gggaacacag 94141 gacatttggc atatattttt gcaatttcct gtgaatccgt aattatttaa aaataacaga 94201 tatactacat atcaaaaatt taatgtcata aagttgatga gtttacctag tggatagctt 94261 tgttaatatc tgctataaga ctactgaaaa tgacagttat gcaagtataa gctcagagaa 94321 ctttcctccc ccttcgtaaa tgaaatgagc aaaagaaatg aaacaggaaa ggcaagcagt 94381 actgaaaaca gggaagggct cttccccata taactatatc tgcgacttca acagctattc 94441 atccagaaac acagcctctt gcgctaagag gaaactttgg ataacaatat gttttcactc 94501 tccaagagag aaaatggata gattaatttt taagaaaaaa aaaaaaacct caccaatttc 94561 atgctgtggc ttgcaccttt aatcccagct acctacaagg ctgaggtgag aggcttactt 94621 gagcccagga gttcaaggct gcaatgagct atgattgatt gtgctatcgc actccaacct 94681 ggagtactaa gctaagagct aagaacacag ctgagagcgg agaagaaaca aacaaatctg 94741 accaataacc cccactcccc tcattttact ggagtgagct gagactgctg gcaaacatgg 94801 cctttgaeet agcctgaact gtagcaaaag tcatcagata tttttccacc aatcaacaga 94861 cagaagtggg gagaaaacaa tcgtagttca taactacaac aagcagataa acgaaggcca 94921 tggtgaggga tggaagaca^'t tgtgatatat caaaggcagg ctcatttaaa actcaaccca 94981 aattccaaac aaaatatata attgaatatg tattaatgcc aaaggagctt gagtgagctt 95041 tagcacaaac cccgccctcc agcccccacc caaaaaaatc actctgttct ctccccattc 95101 tttgataggc atacttgctg ttttctcaca gccaaggtac agaggggact tagaggaact 95161 agaactctaa tacactgcta gcaggaatgt aaaatgaagc atctacttca gaaaaccatt 95221 ttatcagttt ctagaaagtt aaacatagac ccaccatgca gcccagccac tctactccta 95281 agtatttaca caagagaaat gaaaacgtgt ccccacacag ttgtatttaa aggtgatggt 95341 tagccttgtg tgtcaacttg gctaggctat aatacccagt tactgaatca aatagtaatc 95401 taggtgcatc tgtgaaggta ttttgtagat gtggttaaca gctacaatct gttgacttca 95461 agtaaaggag attgctcttg atagtatggg tgggcttcat ccaatcaatt gaaggcctta 95521 agagcaaaaa gtaaggtttc ccggagagaa agaaattctg cctcaagact gcagcctcaa 95581 ctcctgcctg agtttccagt cagccagcca gcctaaagat ttgctaggca ttataatcac 95641 atcagctaat ttcttaaaat aaacctcttt atatatattg atacaatgaa tggttatagc 95701 agccttattt gtaatagcca caaactggaa acaacctaaa tgtccttcaa taagtgaata 95761 cataaacaaa ttgtggtata tccacaattt ttacgcagca gtaaaaagga ataaatggtt 95821 gaataaggaa taaacacata acaaggatga accttaaaac cgtaaggctg aatggaaaaa 95881 gtcagacaaa actaatacat actgaataat tccatttata ttgaagttct agaaaatgag 95941 gactaaccta tagtaacaaa aagcagaaaa attttgccca ctggtgatgg ^agggggcgca 96001 ggtattgtag agtatctgag aaaggacaac tggataaaag ggggcacaag aaaacttttg 96061 agggtgattg atatgttcat tatcttgtgg catggtttca taggtgcata catatgtcaa 96121 aacatcaagt tatacacttt taaaatgttc agtttactgt atatctatta tacttcagta 96181 gagaggaagg aagaaagtgg gcagggtggg ggagaggaaa ggaaacgagg gaggaaaggc 96241 cctaatagga aggattttgg agtttagatt ttaaaatgat aaaggatgtt tgacactcta 96301 ggcatatgac gaatatagga ttatgagtcc acaaaaacca ccaggaagtc atgtatgttt 96361 atacttttaa gtgaaggatc agtggattat caactcccta atgctttgcc tctctatgac 96421 tggctgctgt ccttctcatc ccaatactcc ttccaaagcc ccttgcttaa atgtaagcct 96481 tctttcctcc tttcaacaca tcctgcattc cgtgacaaaa taagttttcc ttaaacagaa 96541 tgtacagcat attatttgta caattaaaaa tttttggcca ggtgtgatga ctcatgcctg 96601 taatcccagc aatttgggag gccgagatgt gtggattacc tgaggtcagg agttcgagac 96661 cagcctggcc aacatggtga aaccctgtct ctactaaaaa tacaaaaatt agctgagtgt 96721 agtgtggcag gtacctgtaa tcccagctac tcaggaagct gaggcaggag aatcgcttga 96781 acctgggagg tggaggttgc tgtgagcaga gatcagacta ttgcattcta ggctaggaga 96841 cagagtgaga ctcggtcccc aaaaaaaaac acattttttt ttaatgtttc ctccttgcct 96901 gtaggaaaaa ggctctgact ccttagcctg ggcatcagag ctctatctaa atggacttta 96961 acctgatttt gtggcactaa ttccattgca gtacttgtcc gctcactggc ctgtgcctct 97021 ctgccactat ttttggaata atgtcctctc tccatcttgt ttactcaact atatccaacc 97081 tctaaggctg tgctcctaca aagcctcccc tggctacttc agcccacaga gatatttaac 97141 tgctctgcag ttcaggacat tcttctgact ctttaaatca catttactta tatatgatct 97201 tgtgatattt tttgttgacg tgtttacttt aattttcttc cataacctat tcattcaaca 97261 aactcaacaa ttatttatta aatgccaagt tagaaaaata ttattgattt tatatagatt 97321 atagatatgt ttgaaatttt atttggcaat ctgcaagtag aaaaataatt ataatgtggt 97381 atatctgtga tagaagtatt agtgcagaga ccatggggaa cataatccag cctggaagtt 97441 caggagagat acgtggaaga aaggacgtca gagccttttt cctacaggca tggaagaaac EPI-109 994

97501 attaaaaaaa attttttttt ttgagatgga gtctcactct gtctcccagc ctagactgtg

97561 gtggtgcgat ctctgctcac tgcaacctct gtctcccggg ttcaagtgat tctcctgcct

97621 cagcttccca agtagctggg attacaggta cctgccacac atggatgata aatatgatca

97681 tattttcttg ttcttttcct cctcagttgt cttccctgaa gaaaggaatg ccttttatag

97741 atgacaaact cccattctca agaacaagga tttttgacca atttaattta atcagatgtc

97801 tggctttgac ctagaaacac agtcacgaaa cttggtgatt agagaccaat tcccaaacat

97861 gagcatttct taggaaacac agtaaagatc tgagagaccc aagagcagaa gggcgagaaa

97921 ccaaaagcca tcagtttgca taggaaacac cttgtttagc ctaatctttt tatttttatt

97981 actctattag tcactacaac tattttctga ttgctatggt gatagatggt ttaaaacaag

98041 ccttcattaa gaattgtcac accatggtct cagtcaaaaa caccaacatt tttattggta

98101 ttgacaatta tgggaatatc caattccaag aagacaagga gacctctgaa ctttctaaat

98161 gaagactcca atcttcctga tctgatggga agcagcttgg caagattacc aaccaccacc

98221 acagagagtg gactctaagc taagacttaa aagataagta gaaattatcc aggtaaagat

98281 gtgtacagag aaggaagtac atccagggga aaagaacaat acgtgcaaaa gtacggaaat

98341 ggtaaaaagt aatactacat agtcaaagcc aagcagagtt cagaagggat ctggtggtga

98401 aaaatacggc tagagaaagc agcaaggatt ggcttctaaa acctatgtag tatcttggac

98461 cttaccctaa atgtaatgag aagcttctaa agaatctttc atttattcat tcattgaaca

98521 aatattttga ggctttctgt gaagaacatc attctaagta gtaaagatac agcagtgaat

98581 aggacacata aaatcctaga tctcacagaa ttgacattcc agagagggaa aggtagacaa

98641 taaatacata aacaaatcat ttaacaagat gatttcagac aatggtacgt actgtgaaaa

98701 aaatgaaaca aggtaatgga cagcgaaaag gcactggaag gaagcctgct tacctttgca

98761 tggttagaaa agatctctct aagaaagaga ccacatgtga gctgcgacct gaaggatacc

98821 gagaagctag gtgtgcaaag atgtggggac agaacttttg gactgaatag caaatacaaa

98881 tgcccttggg tgcaagcttt gcctgttcaa ggaccaaaaa gaaggccagt gtgcctgcag

98941 catactaagc acagaggaaa acactgttat atgctgagat tggaattata agtagagcca

99001 gataatatag tctcttatag gtcataataa ggcaaccaga ttttattcca agaggattta

99061 aaaatcactg gaggttttgc actagggtga gaggtgtgat ttgtattttt aaaagataat

99121 tctggagaat taactataat gaggtaggag taaactaagt taggggctat ttcagtggct

99181 cagacaagag ataatggtag cttagactag gatagtagtc gtagaaataa ataaaagtgg

99241 cactctactt tgggggtaga gtctataata ggtttggttt atggatcata tatgagagta

99301 aaaaaaagaa aataaattaa taatggttcc taggtttgta cctgagcaac tgaataaatg

99361 ggtgctgtga attgagataa aggagattga gaatcacagg ctttgttttg caaattaatt

99421 ttgagaggct tattagacat cccagtggag atttcaggtg agtggagccc attgaaaggt

99481 aagggacagg gtcaggtgtg gtaggtcagg cctgtgatcc caggactttg gaaggccaag

99541 gcagacagat cagttgagct caggagtttg agaccagcct gggcaacatg ggaaaaccct

99601 gtctctacaa aatatgcaaa atattacctg ggcatggtgg catatgactg tggtccaagc

99661 cacttggggg gctgagatgg gaggatcact tgagtacagg aggcggaggt tgcagtgagc

99721 caagatctcg ccactgcaaa ccagcttagg tgacagagtg agaacctgtc tcaataaata

99781 aataagaaac gtaagggaaa aggaaattaa tctgatcatt ggcaaatgca tagtatttaa

99841 agccagggga gtagatgaga tactcaaagt aggtgaagat aaggaggcaa tgaaggccta

99901 ggactctggt gtacatttag atggttataa gaggaataga aactggcaaa ataagtaaca

99961 ctgagcaccc aatgaggtgg agaggaaagc caggagatga agcatcatag aaggcaagag

100021 aagaagggtg tcaaagaggc gaggcagtca tcaacttctg ggcagtcaaa taatataagg

100081 acagaaaagt gaccattgga tttggaaata tgatgagcac tttgagtgga gtgttgagac

100141 agaagaccaa ttagagtaga ttgaggagat aacgagaaat gagaaaatgt aacctgcaag

100201 cacagacaat tcttgagaga cttttctgtg aaaggaaaca gacacagagt cttagcatgt

100261 cttgtctttc tatgggaaat gtaaatagtt tgagatcagg gatagtattt tattctgctt

100321 tttgtacctc tacattacct agcatagagc tagctaatgt gcacttaagt atgttctcaa

100381 ttcttatcgc ctgaatgact ggatgggtga aagaatggat ggatggatgg atggatggat

100441 ggaaggatgg atggatggat ggaagacttc tgatttgcca agaagaggat actggtagca

100501 gaaataaaaa cagcactgga gaaagaagag tttagatttt tattctttgg tgtcagttag

100561 acaggaaagt aagacattag aagagtcctt agataattta tgtaattgtt cacttaggat

100621 ttttaaatgt gatcactgat attggacatg ttcctagtga agcatttttg gtgtttcact

100681 ggttgaagtt aataactgta aaattatttc ccgttcagga cagaaaaaca gaaaacttga

100741 agctcctatt agaaagttca agattctctg gggttcttag gatttactgt tcccaaaact

100801 ctgtcaagaa caagaaaatg acctgtatac ttaactggtc taggcaacag tggaaagaca

100861 attctcagag aagatttgtt ttaagaagac actttccata ggaatcaaac aatagctttc

100921 agtgactaac atggtaagac acagggtgtt agctctttcc ttccaacctc atggctgttg

100981 taccttacct ttcgaccccg tgttcctgaa attgttaaat tcataaactt accaaggact

101041 aaccagcctc tggggaattg ctgtatactt agcaaactta caatggacat atttataagc

101101 cataatgata actgactaat aggaaatacc ctcaactgaa aatgagagat catcatttgc

101161 aaatgagttc ccttgcccag gcaactactg gggaaaatgt catgcaagca aaattaatct

101221 ttgaaatcct ccttttccat tttttgtgtc ttccttttcc ataggcacca gaaatatcat

101281 ggtgcctgga tctcatctct acagaaaaaa aaagtgattt gataaactga tttatattgt

101341 gtccaaatgt gattgtattt tcaaagataa cctaagggga gaatgctgtc tggcccaaca

101401 gcaggctctc gacttcattt cagacactgt ggccaatggc tgggaaacag gtatgaacag

101461 taggtttctg agtcccctgg aattattcca tttatgtagc cacctccatg acaggaagcc

101521 tccctactct tacttcccag tttgttcatt catggcacca ggttgcagat taaaatttgc

101581 tcagtgacct tttatctaat aatgtgttac cttcttctct taaaaagtac aagggacaaa

101641 tgctcatggt atacttttag gagattgtgg ctctctatta acagtattta ttcaacaaac

101701 atttattgag catttatatg tgcatcatgc tagggactgg aacctagtaa gtgtagcaca

101761 tattatttca tttaatcctc acaacaaacc catgaggttg gttttatgat cccaattttt

101821 cagaagaaga aactgatatt cagaaccagt taactaactg gttcaaggtc atgcaatttc

101881 taagatacag aaccaagagt caaagacatg attttaaacc aaagcttttt ctgctactcc

101941 acattgcttc cctaggtgag atctgaggca ttccgcgaaa agagaagggt cataaagcca EPI-109 995

102001 agggaagaca agcttaggaa aaaaaaggga aatgtcctaa ataaacagct ttcctattta 102061 ccagaaacca ctagtttaaa aatataatgg gaaaaatcct attcacttta acaatgttaa 102121 aaaaaaaaaa gatagaagaa acatagggat aaacttaaca catttgtagg atatgtaaag 102181 aaactaaaag atgttaataa tggcctaaag aaaaaaaaac ttacatgtat ggggagatag 102241 accatcttac tggattctaa tatttaatag tctaggtgtt ccatttctca ccaaattaat 102301 gtatacattt aatacaatgt caaacgaaat atcttaggaa ttgcttacaa attgtcagat 102361 aattacaaag tttacctggg aaatataagc atatatgaag agtgaatggg accccaccac 102421 tccccccaaa acaaaaaagg tctgaaaagg acagaaatca aggagagtct tgcctgccag 102481 atacaaaatt ctattataaa ggtgtattga tgaaaacaat ttaatactag tgtagcaata 102541 ggcagcaaag caatgaaaca gcataaaaag accagaacta tacctaatta tgatgaagat 102601 ttaaggtatg ataaacatga cataattcaa atcagcagaa attggcatag atagggttaa 102661 gacaaatagc taatcattag aggggaggaa ggaaaggagg gaggataaaa ttaggttcct 102721 gccttcatct tacattaaaa taaattccag atgtattaca tttaaatttt tttaaaaaaa 102781 gaaaccacaa aatacttgaa gaaaatataa gttgttatat agtcttttga tgggaatttt 102841 tttttttttc agagacaggg tcttgctctg tcacctagcc tagagtgcaa tggcatgatc 102901 atggctcact gcagccttga actcctgggc tcaagtgatc ctcccagctc agccccccag 102961 gtagcaggaa ctacaggcat gcgacacccc atccaactta ttttttattt tttgtagaga 103021 caggggtctt gctttgtttc ccaggcttat ctcgaacttc tgccttcaag cacctcagcc 103081 tcccaaagag ctgggctgat gggacatttt ttaacatagt gccacattac cataaatgaa 103141 aagcttgtaa aatactaatt tttaaaacta atatatatca gaaattttta taaacaaagt 103201 taaaaagcaa acacaaaaaa tttgtagcac ttatgacaaa tatatgtata tatatgaata 103261 caaaaagagc ctttacaaaa cagtaagaaa acaatgaata ctcccaatgg agtattcaaa 103321 actaaactgc taaaagcaat tcaaaacaaa aaacataaac tatgcatata tgtatgtgaa 103381 aaagtttaac cttatcaaag aagtaaactc tcaaagaaat aaacatcaaa taaggaaata 103441 gccttttccc acaaataacc aaaatctgta agaatactga gctgcgaatg tttcagaaaa 103501 aaaaaaaaat catacaccta gttcggcatg taattaatat agatcagaac actttaaaaa 103561 tatttatagg ccaggcacgg tggctcatgc ctataatccc agcactttgg gaggccaagg 103621 cgggtggatc acctgaagtc aggagtttga gaccatcctg accaacatgg tgaaaccctg 103681 tctctactaa aaatacaaaa actagccagg catgttggcg tatgctggta atcctggcta 103741 ctcgggaggc tgaggcagga gaattgcttg aacccaggag gtggaggttg cagtgagctg 103801 acattgtgcc actgtactcc agcctgggca acaagagcaa aactctgtct caaaaaataa 103861 taataaataa aaataaaata tttatatact ctgacccatc aatttgtcca gcataattag 103921 gcatgtgtac aagggtttac acacaagaat gcctattgca atattgcttt taatgctaaa 103981 aaaaattggg gaaaatgctt taaaaatata gattaagact gtacattgtg gtacagtcat 104041 ataatcaata gtatacagct attatttatt ttcagccact gtccaaaata tagcctggcc 104101 taacaacatt ctgttaggat acgcaagcac cgtgaggaga tcagctataa agtatcagtg 104161 tttcacacca ctgctccttt gctaataacc ttcaatggct tttaaagaag taaaaaacaa 104221 aggcaaaatt ccttagtcag cccttaagac tctctgttac ttagctcaaa ctaccctttt 104281 caacaacact gccctaacca ggatgagttt tttgcccccc tggagtacat tcagcctttc 104341 cttatcaaac cttcctttaa ataagtatct tctccaggac cacttcactt tcttccccaa 104401 tttagcattt tctatatctc caggcctacc tctataaagc ctgtcctaac cactcaaacc 104461 ctagcttttt ctctgaactg ctagaaatat ttttctctca ttggccattt aggtaaaaag 104521 gtttttactg tttattacct actcaataaa aattttcttt ttttgagaca aggtcttact 104581 ctgtcgccta gaatgggggg aagtggtgtg atcacaactc actgcagctt ctacctccca 104641 gctcaacagt cctcccacct cagcctagtg agtagctgtg actacaggca tgtgccacca 104701 taccccacta cttttcattt tttatttttt gtgagatgga atctcactat gttacccagg 104761 ctggtctgct gatctcaatt gatcctccca ctgtggcctc ccaaaatgct gggattacag 104821 gcatgagcca caatatctgg ccccagtaag cttttaaggc cattaacatg aggaacagtg 104881 ttctttacac tattttatca gctagggctt tgcatggagt aggagtttag taaatgcggt 104941 tgatgggtta atcaatgtgt gaaaatattc agagccacca aaaacagata ttatgtctat 105001 tctcatcaac aatcaaaatt gagtaaacag ccattttcta atacaggaaa ccacaaaaca 105061 ttgaatggtg acattaaaaa attcccccag caggagccaa ccaatttttt catcctgatc 105121 caagttagca aactgcaaaa gataggaagc actaatgagt ggaaatttga gtagaagcat 105181 ttcttatgaa ggctgtcttg actggatcac atttttattg ctgttggagg tgccaaatgt 105241 gtgtgtttat gctaatcctc cacctcaggc aacacacagt caaggatcct accaagtgtt 105301 accgtcaagt gtctgttggc agctcaaggc cccagcgttg ttcccttgca ctagggaaaa 105361 gacatattcc aggtacaagt actcccactt tgatgctaca gaggagttgc tgaactttgt 105421 gtcattaatc tctcttcgtt agatcccaac cctgtttaaa tcccactatc tgcctactct 105481 gggtcttcac caatttacta gatcatagtt ggagaaaatc tacaaagcct tgctcccttt 105541 agatttaaac aggtctccgt ttaaatttag aattgctaac ttcaagcggg cccttatgcg 105601 acagtatgcc tgtcagtcat actacatttc ctcaattcca ttcatgtgac tgctccatac 105661 ccttccctct ctcttcatac tactattatc tcttcccccc tccctcattt ttaactgatg 105721 atcttgtttc ctatttctct gagaaaatag aagccatcaa aagagagttt ccacaaactc 105781 ctactgcctt atctagccct gtaccatata ctttgcattt cctctcatta ccatggatgt 105841 actgcctatc tgtgcttcta tctaaggcta acccttccac ttcagttttg aatattatca 105901 gctcttacca actcaaggcc attgctctag caattctctc attctctctc attttcttcc 105961 atcaagtttt ccttttcttc aattaacaga gtagctccta aagggaaaaa aaagtcttct 106021 ttttcaatgc tcatcatcac tggccatcag agaaatgcaa atcaaaacca caatgagata 106081 tcatctcaca ccagttagaa tggcaatcat taaaaagtca ggaaacaaca ggtgctggag 106141 aggatgtgga gaaataggaa cacttttaca ctgttggtgg gactgtaaac tagttcaacc 106201 attgtggaag acagtgtggc gattcctcag ggatctagaa ttagaaatac catttgaccc 106261 agccatccca ttactgggta tatacccaaa ggattataaa caatgctgct ataaagacac 106321 atgcacacgt atgtttattg tggcactact cacaatagca aagacttgga accaacccaa 106381 acgtccaaca atgatagact ggattaagaa aatgtggcac atatacacca tggaatacta 106441 tgcagccata aaaaatgatg agttcatgtc ctttgtaggg acatggagga agctggaaac EPI-109 996

106501 catcactctc agcaaactat cacaaggaca aaaaaccaaa cactgcatgt tctcactcat 106561 aggtgggaat tgaacaatga gaacacttgg acacaggaag gggaacatca cccactgggg 106621 cctgttgtgg gatgagggga gtggggaggg atagcattag gagatatacc taatgttaaa 106681 tgatgagtta atgggtgcag cacaccaaca tagcacatgt atacatatgt aacaaacctg 106741 cacgttgtgc acatgtaccc taaaacttaa agtataataa aaaaatatat atatatatat 106801 aaaacaacta aaaataaatc ttctttttct gcaggatcag tccatcacca cacacacagg 106861 ctgtgtttta tgttgttccc cagcttaaga gatcgttctc cagatcccac tgctccttcc 106921 agttgtcacc tcagttctcc acttcttttt gctgataaac tactctaact agttacatat 106981 gatttctgtc cccaggtccc ctccctcagt tgttttgaac ataatcattt atatcattta 107041 tcattttcac tctaattgca caaccaaaaa ctcccttttt ttttagatgg agtctcactc 107101 tgtcacctag gctggagtgc agtggcatga tctcggctca ctccaacctc cgcctcacgg 107161 gttcaagtga tccccctgcc ttagcctcct gaatagctgg gattatacac atgcaccacc 107221 acacctggct aattgctttg tttttgtttg tgtgtgtgtg tgtttttttt tttttttgga 107281 cagagtctca ctctgttgcc caggctagac tgcagtggca tgatctcagc tcactgcaac 107341 ctccacctcc tgggttcaag cgattctcct gcctcagcct cccgagtagc tgggactaca 107401 ggcatgcacc accatgccag gctaattttt ttgtattttc agtagagacc aggtttcacc 107461 atgttggtca ggctggtctt gaactcctga cctcaaatga tctgcgcacc tggacctccc 107521 aaagtgctgg gattacagac ttgagctact gcgccgggct attttgtgtt tttagtaaag 107581 acggggtttc accatgttgt ccaggctggt ctcaaactcc tgacctcaag tgatccgctc 107641 gcctcaggcc ctcaaagtgc tgggattaca ggagtgagcc accatgcctg gccataaaac 107701 tgccctttgt taatatgact gttggcctgc acattgtcaa atccagtggc attcatctta 107761 ctcggccaac ctacggcatt tgacactgtc tgtctttcct tctgttcctc tatctgtttc 107821 cagtatactg gcctggcttt ctttttacct cttttatatg ctcttccagt ctcaggctcc 107881 tttggggatt tgaaggtatg ttgcattttg ctattcaatg aataatgaca agtaatgatc 107941 acttaagaca ttaagtggtc agttccttta ctaggataaa aataattttc ttcccaacat 108001 ggggcatatt ccatttccag tctgactgtt ctgtgtaatc tttgtattcc ttggcagccc 108061 cttttatatc agttcatcta ctgtgcagga aattggacaa acatttgcac tggtataacc 108121 aaatacagtt gaacttttgg cttgactctt agctgaactc accaaaaata atttctgtaa 108181 gagactgaga cgtctacgag taggtttttc agaattagta aacataaatc aaggatacac 108241 aggtagattt gaatttcag^'a taaacaacaa atactttttt agtatgtcta ctgaaatatt 108301 tgtatcttat ctggcaattc tacctggtac agaactaatc cattctcttg aaagatcttg 108361 actctgtaat aagttctttg gtgatggaag ggaggtattt ctgtaattag agtcactgtc 108421 ttcctcccag ttttttatcc tggcccagat ctgcaatgaa cacacgacag aatccagggg 108481 ggatgaagat gggtgctttg caggaaaaaa aaattaaaaa catctgaaaa agcttttgta 108541 ctaaaagaat gtgatctaaa aaagaaagca ggagaacttt ctgtctgcac tttacatcag 108601 aacaaccttg gcgtctagaa gctgtgccct gtgggaagtg gtggtgcttg gtaagagatg 108661 ccaggaccag tggtacccac tgggagcact gccaataccc agcaaggagc atgggtgcac 108721 agtaaggcat tgcactgtga ttcagcataa aataacaata agggaacgtc acggagaaaa 108781 ggccagactt cctttgttta gaatgtggga aatgtcttct gaaaaatggt agtaaaaaag 108841 catgcttgga tggtccactc caggcaaaac tgactaatcg ggggtcaggg atacaacccc 108901 tgcatcatat gtttgtttct gttgggctga catgaggttc actgtgacca ctgtggttta 108961 accccatagt ctcctggaaa tacagccagg tcaagagagc tccacataaa acataatcaa 109021 aaaaataaac tcaagtttcc actgatcagc ttttcacaac tcttatcctt tcactaactt 109081 tggagcaaga tttgagaatt ggatggctat ttgagggcta tttctgcgct ttagttcaat 109141 gttttgttct ttctttatta gagaactatg gttttttatt atatttacac tttaagttct 109201 agggtacatg tgcacaacgt gcagatttgt tacacaggta taaatgtgcc atgttggttt 109261 gctgcaccca tcaactcgtc atttacatta ggtatttctc ctaatgctat ccctccccca 109321 gtcccccacc ccccgacagg ccctggtgtg tgatgttccc cttcctgtgt ccaagtgttc 109381 tgtttatgtg atagattacg tttattgatt tgtgtatgtt gaaccagcct tgcatcacag 109441 tcacttgctt acaagaaaca aacacttcac agatggatca ttatgtgtga taagtgaaat 109501 ccaaggattt atgctcagag gtgggcttaa caggtaggaa gagcagtatt ttccttcaac 109561 catgagtgta tgcaggtttt tcttttcttt tttgagatgg agtctcactc ttttacccag 109621 gctggcgcgc agtggtgcga tcttggctca ctgtaacctc tgccacctgg gttcaagcaa 109681 ttctcctgcc tcagcctccc aagtggctgg gattacaggc acctgccact gtctccggct 109741 aatttttgtc tttttagtag agatggggtt tcaccatctt ggccagcctt gtcttgaact 109801 cctgacctca tgaatcatcc ttctcagcct cccaaagtgc tgggattaca ggcatgagcc 109861 actgcgccca gcccacaggt ttttcaaaga ctaaacttaa aaaaaaaaaa aaaatttccc 109921 aatgaaatat aaaactaaag tgctaaactg tgatagactg ttttacaaga atgccagttt 109981 tcacaagtgt ctatagaaca tgtaatttag ataggtaaga tgaaattttg ataatatttg 110041 atggcaaatt taaacaggta tacaacaaaa ataaaattct aagcccctca accaactgaa 110101 tggactcctt ctctcagcca aaggaatacc aaagtaaacc tgaaaaacta gttttggcca 110161 ggattggggg taggtggggg aagcccaaca tgactcatta ttctctcctc cctttggaat 110221 tcaggcacaa ctgaatgtca gcattgacac taaaacacag atcttaagac tgacaagcca 110281 gactctttgt agcagagagc caggccctgg aagaaatcaa gttattttat cccaaaaaat 110341 atttctttga tatattttca aatggccctg caaagctgtc tcttgtgggg aaaattgaca 110401 tgctgtacag aatttccttc tctttccaag tttttactga tccaggagag atttaactaa 110461 gaggctagca tgtttttttt tttttttttt tgaggcggag tcttgctctg ttgcccaggc 110521 tggagtgcag tggcgtgatc tcagctcact gcaaccttcg cctcccgggt tcaagcgatt 110581 ctcctgcctc agcttcccga gtagctggga ttacagatcc atgccactat gcccagctaa 110641 tttttgtatt ttttgtagag acagggtttc accatgttgg ccaggctagt attgaactcc 110701 tgacctcgtg atccgcccac ctcggcctcc caaagtgctg gcattacagg cgtgagccac 110761 cgtgcccagc acaagacatt taccgtctat tctctctgaa gctactatct agaggcttca 110821 tcaacataat aagacccttg gtctccacaa ctccttatct tatcctatta gtttctactg 110881 attccaggtc tttagataat aacaactctt tcaaccaatt gccaatcaga aagtctttga 110941 atccacctat gacttaaaag ccccactcct tcaagttatc ccgcctttct ggactgaacc EPI-109 997

111001 aatgtacacc ttatatgtgt tgatggatat ctgcctgtaa cttccattcc cctaaaatgt 111061 ataacatcaa gctgtaaccc aaccaccttg ggcacatgtt ttcaggaact catgagactg 111121 tgttgcagac cttggtcact catatttggc tcacagtaaa cttctttaaa tattgtatag 111181 agtttggctt ttttcattga cacaggaaaa ataaagaatt ggaaggtctt tcatcagtca 111241 ctgagccagc ttcatatctg actgaggtca tacagttcag tgatttgtag ctttgctact 111301 tagattgcta tccattatct agaagcatca ggatcacgtg ggacctattg gaaatgcaga 111361 ctttcctcct agaacccagg accttggaat attcttggca catagtaggt gctcaataca 111421 tattgaactc ctaggtgcaa ttcattaatt catgaattaa tgaattaaca cgctctcaaa 111481 gtttagtgct ttttcacaga ctagtctttc tgcctcttaa gcactcagct caccacgctt 111541 ccagtctcac tcccctatta gtctgattaa aatctgctta catgtgagtc tgagatcaag 111601 tgttatctct tctgagaagt cttccctcac tggcccaaag gaatttctcc tctattttag 111661 cactgtccca gttgacttgt cattattcta gtctttttca tattagttgt ttttcatata 111721 tatgttatta aggaaactag tcatttcccc taatagaaca aaattgctgg cctttggggt 111781 tggcaatgga ggggaggctc ttcttgaaaa gggggaagag tgttctccta atatttttct 111841 tacgagattt atgttgctca tctttagcct ttagtccccc attgcctgcc tacagttggc 111901 agagaccatc tgttctctca ctgtcaggaa ctgtctcaat tcttgaagtt cagagtcaaa 111961 aaagaagcaa gttttcctag ctctttgatc aactttcaaa gttttacttc catttgaaaa 112021 tttactaagt caccaggaga tggtttatac tgagaaatat ccactcatac tcttcctctt 112081 caactttctt ccatatacac cctattacag ggatatagtc ttactctata gctcaaaagg 112141 atgaccctat cagaaacctg cacagtatgt aaaacattct caccagaggt tcacttgtgt 112201 atttccaccc tagaatggaa gctctacaaa agcacagaat gtatcatttt aactttagat 112261 tctattttca cacccagtgc ttgacacatg atttgaagtt aatatttatt tatcaagtga 112321 ttgttttaaa atcatgactc actcaacaaa gttataagaa taagaatagt gttacagaat 112381 tggtatacac aagctgacca taatcaacac acctattatc atttttttgc gacaggttct 112441 cgctgtctca ccctggctgg agtggagtgg catgaccacg gttcactgca ggtttgaact 112501 tccaggctca agcaatcctc ccacctcagc ctcccacata gctgagccca caggtgtgtg 112561 ccaccatgtc cagctaactt tttaattctt tgtagagaca gggtcaccct atgttgccca 112621 agctggtctt gaactccttg gctagagaga tcctccctcc aaggtccccc aaaatgctgg 112681 gatctcaggc aagagccacc atgcctggcc ataatcaata cacttttaag aatgctagaa 112741 tgttatatca gatgcatact tcagcactat ctcaagcaaa ctggggtgtg ggttattcta 112801 catataaagt tcagcagtgt tgttccacag tcccaaactc caactgaggt caaatgtagg 112861 gtgcagcaag gtcactgggg ctgtcatcaa gggcctctcc ttgcactctt gccaaccctg 112921 tttcttgatt gtctctacca ccatgagtca ccagcaatct cccacagtca cttgtttaaa 112981 agttcacaag tattgtgtga attgcaggca accccttgac tccctgattg cctggtcttc 113041 ttccttgggc tctaccattt tttttcccca gcactctttc tgctgctcta aattttaatt 113101 catgcaattc catatgtgtt tctctatcat tcttcatctc tttcctctcc cttccatcca 113161 attttgtttg tctgtttgct tgcttgcttg ctttaataca tttctctttt tctgagaagg 113221 cttgagtcca aaactctcag ttacctgttg ttctgtttcc cgttagttaa tctccgaacc 113281 ttcataaatt aaatctgaca aagtcccctg actaacaaag gaaatgcaca agtcacagta 113341 aaaggggcac acacagaaca caaatagacc cagggtcttt tctgttcatc actcagcttt 113401 ttataggaga tccaggagaa atgaagtgga aagggaagtg tgttgagtta ctatacaaca 113461 caagagtaaa ctttcttata agtggtaatt tttttttaca ggaataattg aaaatggaaa 113521 ttaccttctc tactcatagt aagtactcag tgcgttcttg atgggatgag aatgtgtttg 113581 agctttagtg taaggcagaa ttctgtttag tctgccagta ttggagaaaa ataaaacaca 113641 aagggactga catgtaggaa gtggcacctg ggagggtctc aattcttcct attacaaaaa 113701 tgccccagag aaataaaaag cttgtgtaca tgttgagatg ggagagttct ctggcccccc 113761 tcgcaggatg tgtgacagtg gggtggctct ctgctgcgcc accatgagct caaacccctc 113821 ataggagggg gagcacacag gcaggaaggt gcaggagctg ggcgagctct ttgggctctg 113881 gccccgtggt actgtctaga ggtgggtgcc tgcaactcct gaaagcccaa gtgggcatgt 113941 gttacagtgc actctttcag ctttgctgtc tgcagcttaa gcgttaacca gctcagtttc 114001 ttcttggtac ccaggtcctt gtctggcatc caggaagaat caggttacac atggacttga 114061 aggatgaatg tgggagtttt atggagtggt ggaggtggct ctcagtggga tggatgggga 114121 gctggaaggg ggatggagtg ggaagatgat attctcctgg agtttggctg tccagcagcc 114181 gatctcctct ccagtcgtcc ccagcctctc gacgttcaga tgctcctctt ctctccttct 114241 ctgccatgct gttctgccgt tcatctgcct gtctctctct ggagcctgga atttggggtt 114301 tatatggtac acaataaggg gcatggcagg ccaaaaggga actttttagg tgcaaaaaac 114361 aggaatgcct cttctcactt agggctatag attttcaggc ttgaaggtgg ggcctttacc 114421 agcgaacctg tatttccctg tctcctgtgc atatcaatgt aatcaaatac tgggctgatc 114481 caggatgttt ctttagacca attatgggta aaataattta cattcaggtt tttatatttg 114541 cttttgtcat ttctttttaa gcaatcatgt aaaatatcta tacgacagta atagatgata 114601 gcgaacctaa ttaaaattac cagaaactta agaatctcta atgatttcaa ctgtaactaa 114661 ggttatttct ctttatgttg aacaatgttg ggagataaga cacaagagtt tctgaagtat 114721 ttcagaaaca caaagaggga ggttatataa ataatatttt tttcctactt tgggaaaatg 114781 aaagctagtc acaaagttaa acgagtggtt attttaatat ttaaaataca ggcttggatg 114841 tatttcctgt taaagaaaat aaaatgcaga atattcaaaa cgtctgacca cccttctaag 114901 aaaatgcatc tctgaggtat ttttccttag aagttattgt aaaaatcctg gagaagcttg 114961 aacacagcaa agcaaacagg atgcagagtt taatctgtgg aaagcttagg gaagaaaagc 115021 aaatcattaa aaataggtct tcctctgaag atttttaaaa cgcaaagagg gtggaatagc 115081 aatgataata aaaaagctgg catagagagt ggcacaattt gctgtgccac tgagctgact 115141 ggatgtgttc tgaatttcta ggcattagtg tacctttcca cacgcattct ccctttaaaa 115201 aaaatgccca cacactgaat acttttttca tgcaatttaa aataagcgca ccatctagtt 115261 tacagaaatt cactagaagt tatttatcct aaaatagcag agatctagaa gaattttgag 115321 ctctaggaca ttttagacac acagaaagaa gaatctggac aagtcttgac cagacatgac 115381 agaatagaaa tttcttttcc tatttatctc tttgaataaa attttcagga tcttacagtg 115441 gacaagtttg ttatctacac attgtgaagc acattgattt ctcctctgta gccttaggaa EPI-109 998

115501 gatctgagag gtgactgagc tgattgaatg atccgtgacc gctctactgg gaccagtagt 115561 agaactttac tggtggagac ctgctggagg tttgagagca gactttgaaa attactagag 115621 ctacacagat actgtgtggc taactggatt atgtttagag gctttcagaa ctatgctgct 115681 gctgctgcag tgtagccagg acgcacagag aacatctaag gctcttgaat ggggcgatag 115741 ggacagattt cagcagccat ctgacttcag tgctcatttt gatgctttcc ctgcagggtg 115801 cagtgtgcag tgtgcagtgt gcagtggtgg gaggctcaca caggaatact tgcttctgta 115861 gccctaattt ccggttcaaa ctctgcattc accttgacag attctttcct tggccaaaat 115921 ttagttaggc ttctgggctt tctcttatgc ccacctgcag actttttggt aaaatccagt 115981 tttagtaaag agctctgcta agtcagttta gcaagaatcc ccacctcaaa agtcactatc 116041 tccctccctg gtagtgtctg gcttgtcttc agcgagaatt ctattaggtt ctgttagatt 116101 agaatcctcc ttacccttga tgcttcctct tagtattttt tcatccactg actccttgac 116161 ccaccttgct cctcggctat aaattcccac ttgcccatac tctgcagtta agactatttt 116221 ctccccacta ctgcaaaatc ccattgccat ggtccctata ctatctcaat ggtaatgaat 116281 aaagtctgcc ttaccatgct ttaacaagta acattgaacc atttttttct ttaacaatct 116341 gctgcacaat gagattacta aaactttatt ccattttgcc atgctggatg tcctcaatgg 116401 aatggctctt gtgagcacca aatcattgtg agaaggaaaa cccatctctt acagccccct 116461 gtaacgtgat gtatgttaca tgtgatgtat gttacatagt tttttttcat gttgatcact 116521 ttttgcccat tttcctatat cttatcagtt ggaagactgt ggaagtttgt agtactaagc 116581 cacaagatga ctaagaagag ttgaaagggc aagtggggct aaaaacagat tttgtttgac 116641 ttaccccacc attcccccta tcatggggct gaatctgcct ggaggaagga gcatctttat 116701 ctttgtactg tgaaccacac agtctagcag cagcacagcc aaggcacttg gggtttcatg 116761 agactaagta catgcaattc tattgtaaag gcttaaaata tatacaactg acccttgaac 116821 aacatgaatt tgaattgcat ggtcagttat acgcagattt tcttccacct ctgccacccc 116881 tgagacagta agatcaatca atcctcttcc tcctactcct cagtctactc aaagatactt 116941 gaagtctact tgaagatgac aagcacaaag acatttatga tgatccactt ccacttagtg 117001 aatagtaaat atgttttctc ttcctcctaa ttttttaaca ctttcttctc tctagcttaa 117061 tttattgtta agaatacaat ctataataca tatgacatac aaaatatgtc ttagttgact 117121 gtttatgtta tctgtaaggc ttcaggtcaa gagtatgcta ttagtggtta agttttcgag 117181 gagtcaaaag gtgtatgtgg actttcaact gcaggggggt gggcacccct gcccccatgt 117241 tgttcaaggg tcaactttac tgccaaaggc aagcctttac atccactttt tccatcccat 117301 cagtaaatgg aaaaagatag ctacagtatc cctgcgtcaa atcttttttt ttgcagatca 117361 caaattggcc actcaccttg ctctgtgagg ggtaaaatgc cccactttct ttagtaatat 117421 ttaagttaga taatatttaa gttataaagt tgttctttgt aatcgttaat tgtaattttt 117481 acatagtttc tttcaaacag aaatagcatt tttgttagat aacctcccgt atagatgatg 117541 aaactccttt taagggctat ctgaatttta attccttgaa aaggcagaaa ttggatagct 117601 agtagtcata aatgtactgt ggcttccccc aaccatctgg gctatataga agctgcatcc 117661 ttggactgca gtagaggagt cttacaaagc acagagcaac ttctctcctg ggttgcgcta 117721 gttatgatgg caattttaaa tgtgtacttt tacccaaaga aaatccttat tatcaacaat 117781 cacaatgcca tcataaccat ggtataaaaa attcaaaatg tcccagctga agtggaggca 117841 aagactcaag ttcatggagt cagagtttcc ttgctattcc tctttttcaa atgaccattt 117901 agtaagcacc tgaagaaaat actatggacg gcattgaaaa gtgaagatag gtttaatctt 117961 ctcgaaaatc taattctcca gatgaaacgc tgacacttat ccaccccaca gaccctatag 118021 cagatgtgtc actggccatc acatttgaca cagagaagtc ataactcagt cagcacagag 118081 acatttccat gagtttctga accatggaca gaacgtcgtc tgtgggacat gaaaactgga 118141 acttagagga caggcacatc tgagaaatgg gcagtttaaa ggcagaacat agcacatatg 118201 tgactgggtt ttagaagcaa atttacaaga cgcactcttc ttcatcctaa ataatctgca 118261 accaaagctt ccaaaaaaga caatttagga atgcagaggt gaggagtagg gaggggaatg 118321 ggatgagaga gagtggagat taatggtggg cagagcgagg tttagaactt agtggtttct 118381 tcaggttctg aactgaaatt tgtatactgt aaaggcacaa acaccatttt taacaaaagt 118441 gagcaggact tcctatctgg ttcagaaaat aggtgaataa atagtacgaa ttattaaaaa 118501 taataatttc cacttataca taggaaactt gataggaacc atgataaatg cttaactctt 118561 aatcttcaag gaactctgct agggatataa tattataaat cttgttttgc agatggagaa 118621 attgaatttt aacccaagtt atcataaccc ttaaatgatt aaatgatact gttacatgag 118681 aaagctgcgt atctgtttcc tggatttgta gccataattt gtgtctcaag tcccttttgc 118741 tgccagctat cttgggtagg tgtgttccct ttgggctgtt tgataccccc acatttatct 118801 tttttttttc tctttttttg ttgagagagt ctttccctgt tgcctaggct ggagggcaat 118861 ggcgcgatct cggctcactg caacctccgc ctcctgggtt caagtgcttc tcacgattct 118921 cttgtcccag cctctctaat agctcggatt actggcatgc accaccacgc ccacctaatt 118981 ttgtattttt agtagacaag gggtttctcc atgttggtca gggtggtctc aaactcctga 119041 cctcaggtga tctgcctgcc ttggcctccc aaagtgctgg gattacaggt gtgagccacc 119101 atgcctggcc ccaaatttat ctttaatgcc ccaaattatc tagttcccat gactgggctt 119161 ctgctttgat cctttctgca cttgctggac cctctccctg ggaaatgaga ttgtgtcctg 119221 agcccctagt tagaggctat gtctctgctg ttcctgaatg ggcctcctgg atgagacctc 119281 attaaaagtc taattctctt ggagaattga gagataccta tttgtctcaa aatcattgaa 119341 accaattaat gtattatgag cctctatcca gtgatttgta cctcaattcc ccaatccagc 119401 tgtcaaggcc aatttgttct accttaccta gtaggtaagt ctggaattgt agctgtggca 119461 ttttcagtaa tggtactcta ggttagcagt ccccaacctt tttggcacca gggaccagtt 119521 ttgtggaaga caatttttcc atgaagggct gggcagggga gtggtttcag gatgaaactg 119581 ttccacctca gatcatcagg cattagattc tcacaaggag tgcgcaagct agatccctca 119641 cacatgcagt tcacaatagg gtgtgcactc ccatgagaat ctaacaccgc tgctgatctg 119701 acaggagaca gagctcaggc agtaatactc atttgcctac cgctcacctc ctgccgtgca 119761 gctcagttcc taacaggcca cggaccagta ctggtccacg gcgcaggcat cagggacccc 119821 tgttgctagg tataagcatc tggctgctgc atgtcttctg tgtagctaca tctgtatgtg 119881 tatctgatga gatataaatt atttgattat aaattacttt cttcatatta gagttgtgaa 119941 tgagtatcac atataattat acataaacta ggaatatgct ttttaataat gtatataagt EPI-109 999

120001 aagtttcctt aactatgact ttcatcttag cgtagtaaga gggtgctaag aaatatttgt 120061 gatgaaaata ggcattggta gagttgagac cactgggtga tgaaagagtg taaagatttt 120121 aaagccttca gatgctggtt caaggtgaga aatgtgattg ggagcaaatc aattaacttc 120181 ttgaagtctt atagggcagt tatgaatact taatgttaac atatgtaaag ctcttctgcc 120241 ctgtatacag taaatgctag ttagctatta tgatcactac taaaatgggg atgacataaa 120301 cctcataagg ttttaagtat tatgcaagat actatacaaa gtccagtaaa tatcacattc 120361 aattgaatcc atgatgtccg attattttag ctacttccaa gagagaaaaa aatgctgtca 120421 gttttactgt tcttatagag agcaaggcag atcccaattc ccaatgtggt aacgtgaaaa 120481 tttttgcatt tgaatcaaca aaacactttc tcctttcttt cctactattt aacaactggt 120541 aagtctatac tcccccaaat ctggaattct cctttcttat tctttttcct cctaccaaga 120601 ccgcaggatc ttttacttgg ctataagggg taaacctcaa gtagtacaag ttctctgtat 120661 tacttttata ctctgtcaca gattcccttt gtttcctcat ctccatgtga atttagttaa 120721 attctcagca ttctgatcct tactatacaa ggtaaatgaa tataaaaaca aaacgaaaca 120781 aaaacctctt cctatttaca taaggcccca acctaatatt tagtgatata tattaatgtg 120841 aacaaggaac taacgaagac tgggaagaaa ttcacagact tgagagaaga aatggcagga 120901 tttcctggga acaatttcat gtaacgtcaa aggtggtaaa aggtcaaata gaatgaagat 120961 ggagaatacc ggattttctt acaaaatgat ttcccaggag atctcatcaa atgcacgagg 121021 ataccttctc agtttcacct agtgagtaaa agactggtaa catagctcac ttacaatttg 121081 gataaacaaa actaaacaaa caacatcaaa atttcagaaa aaataatagc aaaacagaaa 121141 tcaaacactc aaatttttgg tccttctgtt tatttcattt tggatactca gtgaatgtta 121201 attaaccagg aaacttaaaa gttatttcaa ttatgaacct cttcaatcct tcatcaatta 121261 ttttgagtat tctggtctta aaaacatctc tttcttctac aaacttctga aagagatgaa 121321 cacctccacc tacaccaaaa taatgtgctt tgctggccaa aagtacacgt ccatttttac 121381 ttaacagtct aaggaaagtc tggtgcaaat tactataata atctgggttg taaatggttt 121441 ctgaggtgag aatgagatca tattttacaa aaagtttttc actacttagt acaagcttac 121501 aaaactcaga ccactcacca gaaaaaaatc ggcatttata tagttgtgtt acttttggtt 121561 tcctgcatct tttcacatct ggctcattta catcattttc ttcatcttcc aaagtggagt 121621 tagctactac attaggtaag gttacttcat caatcaccat actgttataa tcttgaaagt 121681 gaatttcttt ggaccctccc ttgaatgcag ttatacctag taaacctgat ccacaaccaa 121741 gatccaagac ttttttccca gcaaatttca ctttggcctt tgtgaaataa gccaggaggt 121801 caaaggtaca ttcccagatt tttaagcctc cctcataaac acctgtaatc agatcagagt 121861 gagaagaaaa gctttttgaa actatgtttt ctccagggaa gttctctttc aacaagatgg 121921 ttttcactac tgataactta acatgctgga aacctggtaa tgtttctatg actttatttt 121981 ctaacatctt ctttaaatct ttaggcatag catgctcttt ggcagctctc aaggagggct 122041 gttttccatg tggctccaag ttccttgaac tgctggctgc actgagtgga ctgtctgtgt 122101 cttgagaggg agctgcattt tccattgact tatgttccca caagtgatcc tgaggcaagt 122161 caaattgttc tgcagaacat tttctgtccc tctcttctcc tttttgactt tctgagactg 122221 acagctcttt tgaggaatcc agggtcaaag ctccatctct aatgggtgtt aattcatttt 122281 ccagatggtc ttctatagtg aaattaaact gaaaggtcat cctcttatta aatgcacaca 122341 atctttaaat tcagattctt caacttctgg atagaatttg atgatacaca caaatctgcc 122401 tcaattattc aattagtttt gttgggccca atttctcttt agcagcttat acatggtaac 122461 aaatatttag agatatttcc aaatgacttt ttagacgtct ttggtcctct ttccaagcag 122521 ctctggaaag aaaaaaaaaa aaaaaagaaa gaaaatgatg attaaagcaa aatggcacat 122581 ttcactaaag tgtaatatta aacagccacc cccacccctc cctgtcccac catacagctg 122641 ctttttctta aaaagttgtg gggaagagag agagataaga gatttggaca ctcatacaca 122701 ccttaagggt tccaaagtgg gagaagaaaa tcaactataa aaacaaacag aagaacaaca 122761 gcaaccacca ccactaccac ctggacaaac ataaagtcca agatattcag acaggacagc 122821 ctagctactt gctgtctttc agctgtcttg atttgtgtcc aaccatattc accccctaag 122881 cttccagaat aacttcactt ctgtctttta cagaagaggt gcagtatttt attttggtaa 122941 gtcagcgtcc ctttaaaaac atgcataggt atggcctggt gtgtgtaaat tcatccaaga 123001 cttcactcca aacatttagt cgagaacagc agccctaagt gtatagaagt gggggtaatt 123061 tggcaataat tagtaaagac taattcggtg gcagagcaaa cgcaaactag ggcactgcag 123121 tagtttggag agacctgtag aaataagaag caactttatt gagaatcttc tatctactgc 123181 gctagacact ataccatctg cctcaatttt cacagttctg gcaagtggga tctttgttcc 123241 ctttatacaa gatttacaat ttgggggaga ggcgggtcac ccagtcccgc ggctaggaac 123301 gcgcctcttt cctctcccat cacgctgcaa ggcttggagt cacttccggc tgcaggtccc 123361 ggaacaaatc cgaccccaga agtggggact tctggccctc acctccccat ttgaatgtaa 123421 tgtttacagt gatccagacc tggggatgct tgcttcccga cgtgtcctgg gatcgcgctt 123481 ctgaaaaagc tcacctcaca acgcctcctc cggacctaaa tcgcgcacca gtgagtcgag 123541 tcctccaggg gctagagaag cccgactttc tttccggcct tgagggaccc gggctcacca 123601 agaaaccagc cgccctcctc tctatggttt tggagccggc ggagagcgcg caagggttgg 123661 cgggactgcg agtttccggt ctgggctttg gcgggtctgg tttgaagctc tcctgtttga 123721 cgaaagtatg tctcaggaag gtgcggtccc agctagcgcg gttcccctgg aagaattaag 123781 tagctggcca gaggagctat gccgccggga actgccgtcc gtcctgcccc gactcctcat 123841 atccttcctt ggttgtcact tctacctaga gaagggtgtg ggcgggtcgc gaacctttct 123901 cttctgtccc ttcagaccca ccgccaggct gggttatatt accgcggcct gaaccccctc 123961 ttttctttgt cagtgagtgg gatgaaaagt gagggactgg aggggaagcg acaaccgtgg 124021 tagatttaag taaggctttg gccctggaaa gcctcgcgga cgtgttctga cccaaggttt 124081 tagcagtgga tgtggcgttt tcttccattc cttctttcag tttttctgta ctcgttgctt 124141 gcaattaagt gtaaatactt ttgctagtgg ataatggggg aggcaaggac tgagacctgc 124201 ggtatgacga tagctctggc tcttaatagt ttgaggtaaa gcgagatact ctgagctttt 124261 gtctcccgta aaaagggtgg tgaatatgaa taagggcttt cttagcgtta taagaattaa 124321 agggcatagt tctgtggtgt gaaatcttta aaagatgttc agtaaataaa aatgattttc 124381 ctccttcccc tctcagacct ctttttcttc tttctttctt tttttttgac aagttctcac 124441 tcctctcacc caggctggag tctttctgaa agagttcttc cgcttgttgt tggctttcaa EPI-109 1000

124501 ctgttggatt tgaggcgctt agcgccttct tcgtccgggt gcagcacatt cttgattggt 124561 ctcatgcctt tgtggttgta aatgtgcctg gaatcctagc ctttcatggt aaaccatatg 124621 tatatgtatc tttttcacaa catttgagcc cagctttata caattacact caaaagaaaa 124681 aaagtaacct tcacttgaga gaatctcaat actgcacaaa tattgtgcag ctaaagccct 124741 atgtaatcac atagaagtca ttcacctagg cattagcaaa atctcagaag gtgccaaagc 124801 cccctttttt agtttttgtg taggtacaga actgccgtct tcaaggagtt tcaacttgaa 124861 aacaaatagc caccctcaaa acattcaaaa acacttaaac tgcgtgcata atgtgtgtga 124921 gacatggtgt taggctttgg gagaacagag acacggaacg tgattcctct tcttccccac 124981 aagcttatag agagacttca ttaagttgaa agtcaacatt cccacctagc tttgcacttc 125041 aaacgacata ttcaaaaaag cccaaacttc ctctagtttt cttcatctga gtaaatggtt 125101 tcacaaactg aaaccttgaa tcctctctgt ctcacacacc cgatcagtaa gttctattgt 125161 ttctgattcc aaactatgtc ttgaatcaat ccgtttatct ccatcctcat tgctaccact 125221 ctgattccaa acccttatca cctctcactt ggagtattaa tagtttcctt gtttctactc 125281 ataattcatt attccaaaaa agttaagagg ggaaaaacat agatctcgtc atttcccttt 125341 ttaaaccact ttaccttcaa ggttccaggt gatctaagcc ttgcccttct ctcataccta 125401 gttaattaac tacactctgt tcatgaatac attaggctca cctacctcaa gatctttttg 125461 ctcagcctga tttgttctct cagccttttg catatttcat gtttatgtct tggcccaaat 125521 gtcacttcct tagaggggct ttttcagagc cttcaatctt aggcagttcc cccaaacgca 125581 gtcttacact tgtatcacat tggcctgttc agttttctaa aaagcacatt accattaaaa 125641 gaaatgctct tgtttgcttt gtatattttc cacttctaca cattatgttg caaagttcat 125701 aaaggcagga tgttgatttt cttcacagcg ttaccctcag cacctagaac agtgcctgac 125761 acatagtaag cattcattaa agggctaaaa atatttcatg ttttaaaaat acttgggagt 125821 ctaattagac aatacttttt ttcagcttaa tggtagtatt ttagcttcac tattttaaca 125881 aatgaaaaat ttgcaataaa tctacaatgc cattaccccc caaaatcttt ttcatgtttt 125941 gcattttacg tattattttc caggccttac ctgcatgtct gcataatcat aactgactaa 126001 ttttggaaca gctggtaatt atttgagctt tactgaaatt ttttcatgag gccaattcta 126061 ccctactgaa ctcaaatttg agttaatgat gacctcattt tgattgctgc tgtaaaaaat 126121 aagatttcgg aagaggaatg aattcttgta ttactgtggt aggactatgg gttttttttt 126181 gtttgtttgt ttgttttgag acggagtctc accctgtcac ccaggctgga gtgcagtggt 126241 gcgatctcag ctcacagcag ccaggttcaa gtgattctcc ttcctcagcc tcccgagtag 126301 ctgagattac aggcacgtgc caccatgccc ggctaatttt ttgtatcttt agtagagatg 126361 gtttcaccat gttggccagg ctggtctcga actcctgacc tcgtgatccg cctgcctcag 126421 cctcccaaag tgctgggact acaggcgtga gccaccgtgc ccggccgggt tattcatttt 126481 tcttattaac attctttgat gattcttatg gtgttgttac agtaaaacat ttctaacaat 126541 tattctaaca attattcttg atggtgtata tgaagaattt attgtcgtgt atttgtaagc 126601 tgctatgtgc agaagaattt cagtcaaata aagttggtaa gataggtatg taagtaatat 126661 gaaaaaagat agaaggtgat gagtgactta ggtataaatt aagtacaata gaaatgttga 126721 ggaaagaaaa atttcttgta atagaaatcg gaagtacaaa ctgggcatgg tggtgtgcat 126781 ctctaatccc agctccttga gaggctggta tgggaggatc actttagccc aggagcttga 126841 ggctgcagtg aggtgtgatc atgtcaccgc actccatcct gggtgacagc aagaccgtct 126901 ctcttttttt ttttttttga gacggagtct cgcctatgct ggagtgcaat ggcgcgatct 126961 tggctcactg caacctctgc ctcccagttt caagtgattc tcctgcctca gcctcctgag 127021 cagctgggat tacaggtgtg cgccaccatg cccagctaat tattttgtat tttaagtaga 127081 gacgggttct caccatactg gccaggctgg tcttcaactc ctgacctctt gttcgcccat 127141 ctaggtctcc caaagtgctg ggattacagg tgtgagccac cccacttggc cccgagcgag 127201 accctctctc taaaaaaaaa taaataaata aatcataaac ctgtggatta ttgtagcatt 127261 gtttctcatc tgtcaaaaat atttcatgac tatgcatagt ttgaaaaggc aagtttgtcc 127321 ctgggcaatt ttcaaaatat ttctttaatg tgttttcaca atactgttta cctaataaat 127381 cttaagtttt taaaagcaaa attaagccag taatttgagt ccaattccaa tctcttatga 127441 gtcattgctt aaatttcaaa agggttttat ttttttttta ggtttgttct gagtaatgaa 127501 taccctatta ctatgatact agtatcttcc ttaattatcc tactcattgt ctcaacattc 127561 tgacagttgg attgagcata ttcgtaagta aaattgtttt aactgtatga tgtactttga 127621 tgttaaggtc cgagtcccca catacctcgg tagatgtgtt cttacagttt tgtattccct 127681 tgaaatgtaa ctgttctcta tgttacagcc tttataacct tcagttactt gaaatgaaca 127741 aattcattca aattccagca cttaaaagtt ttaaattaca ttttggataa ataccaaagt 127801 gttttgttga tgatgtatgt ataaacaaat tgtaaatatt aaacgttagt tgttacgatt 127861 agacctatat aaaacatgat atgcagtcta ctgaatagct atcagcctct aacatgttta 127921 gtgtcattta gaaaatgctt tctaaattgc caaaagctga ttgtctaggt gataacaaat 127981 ttaccatttg gaggaagttg actttctcat tttcatgtct tcatcagtct tacttgatga 128041 gattcattct tctagtcaga agagagttta gactgctcag tttactcata ttttgagtta 128101 gcttttctat ttagagttca cttggttgtg gaatattcat ttataatttg aatctacgtt 128161 gtgtaatggg acctaatttt tttttccttt gtttttgttg gagtctcgtt ttgtcaccca 128221 ggttggagtg cagtggcgtg atctttgctc actgcaacct ccaccttcca ggttcaggtg 128281 attctcctgc ctcagtctcc caagtagctg ggattacagg catgcttcac cacgcctggc 128341 taatttttgt atttttagta gagatggggt ttcaccatgt tggccaggct ggtctcaaaa 128401 ctcctgagct caagtgatcc tcctgccttg gcctccataa gtgctgggat tacaggcgtg 128461 agccgctgag cctggcccca gagtttgttt tgttttgttt tcaagacaag atctcactct 128521 attgcccagg ctggagagca gtagtgcgat catagctcac tgcagcctga actcctgggt 128581 tcaagctatt ctcctgcctc catcttctaa agtgctgtga ttacaggtct gagccatgat 128641 gcttggcctg tgtttttgtt tgtttgtttt gggggacagg gtcttgcttt gtcaccaaaa 128701 ctggagtgta gtggtgcgaa catagctagc tcactgcagc ctccatctcc cacgctcaag 128761 caatcctctc acctcagcct tccaagtagc tgagaccgca ggtgcgtgct accatgcgtg 128821 gctaattttc tatttatata tttatttttt ggtagacatg aggtcttgtc atgtttccca 128881 ggtggtcttt aactcctggg ctcagacagt cctcccgcct cagccaccca aagtgttggg 128941 attacaggcg tgagccacca tgcgtggcat aatttttttt aagtaaatta tttttttatc EPI-109 1001

129001 ttgagtatag aagtgattca tgttcattgt ggaaaatatg aaacatatag aaaaacagaa 129061 aagattacaa aacatctaat ctgaaatggt taagattttg atgagaacag tctcatctca 129121 tttccgtata ttcctgccag cctatccatc attcttcgta catgtttatc tacattaaaa 129181 ttggtgttat attttggaaa ctttttgttt aactacattg tgaacatttt tcatgtttta 129241 aaatgtcatt ttaatgatgg cagatcctat tcaatagatg tacacacacc tatttaactg 129301 gtccacaatt gttggatatg taggtcgttt cctttctctc tttttttttt tttttggcta 129361 ctacttaata gtttctctgt atagaatgtg gtattttgaa agtgtatcaa gctttagatt 129421 ggtagtattc ttgcatttaa taaagggcag tggcctttgt tgactgacat gacaatattt 129481 ttataaaatt tgttatttgc tttacagaaa ttttgaaaat tattgtagaa atgtttttac 129541 ctcatatgaa ccacctgaca ttggaacaga ctttcttttc acaagtgtta ccaaaggtat 129601 aatactatta cctgaaaata catgttataa ggaatctagc ctcagtctta gatgatttat 129661 tattaattat ggctctcttt ttctaatata tcaaatatat tcaaaataaa aataaggagt 129721 aagtagatct catgtgagac tataatggtg ttagtgtgat cattaggcag ttaaaaactg 129781 ttacaggctg ggcacggtgg ctcatgcctg taatcccagc tctctgagag gctgaggtgg 129841 gcagatcatc tgaggtcagg agttcgagac cacccatggt caacatgatg aaacctcgtc 129901 tctactaaaa gtacaaaaaa ttagctggac atggtggcag gtgcctgtaa tcccagctac 129961 ttgggagact gagacaggag aattgcttga gcctgggagg cggaggttgc attgagtcaa 130021 gatcgtgcca ttgcactcca gcctgggcaa taagagcgat gctccgtctc aaaaaaaaaa 130081 aaaaaaaaaa aagaacttat attttcagat tgtgtggttc ctttactaac tgaatttaaa 130141 ttatttgtag tcaattttaa atgctcttgt attttaaagc cactgtactc cagcctgggt 130201 gacagagtga aacccttaat tcaaaaaaaa aaaaaaaaaa aagaaaagct ggaatattgg 130261 caaaatcaag taactaagag aaaacattaa attcacagaa tacattatta cattttagat 130321 atatatggta tatgttttct ctgaaaagca caagcatacc ttttttgttt taaatggagg 130381 gaactaaaga tactttggtg ccaaaatgaa acattatttg taattaatct cttattgaaa 130441 tgggtttcta actttagctt tgaatcgtaa tctttcaaat ttcttgtact catagtcact 130501 tgatgattct ctatctgaaa tatttcttag aatttgttct tgaccaccag aaaaagattc 130561 aactgttaca tagatgaaaa tggatgttga gtgttaacag gcctatggga aacagtattt 130621 tctttagcta cattgtattg ttgactgtgt tgctattctt ataatgttta ggtcatttaa 130681 attgttagaa agatccaagt attaagatct agggtggcta acttttcaca gacaaaaagc 130741 ttgtttgtaa ggtcatttac tataccctta attcaggaag gttagcttga attgggtcaa 130801 aaggaaactg gttagaaaat aagtgagtag tgaataggcg attcagtgca aattccttcc

130861 agaaaatacc cttgtaaatg actgtatgaa tgtggattct tcaagacagt caaatttatt 130921 gtgcgaaagt aatactttta ttttttgcat ctctaaaaca tgaactttga gtgatttttt 130981 aaaaaaattg atgctattaa atagattcaa accatagaaa tggaaaataa atttctgttt 131041 ggggcttttg gggggattat gttgtaaaaa taccttttct ctgtattttg tgcttaatta 131101 ggtacaattg ttaagctaga tgatagcctg tggatgttac tagtgcaaaa tcaaattatc 131161 gtattgtgtt ttctctgtaa agttttgtct tgtcttttct agtgatttct cttattcctg 131221 tttattactt gatttgtttt tacagactgt gaaattattc gatgacatga tgtatgaatt 131281 aaccagtcaa gccagaggac tgtcaagcca aaatttggaa atccagacca ctctaaggaa 131341 tattttacaa gtaagtcaaa tgtattagaa agcaggagag agagggagct taaagaatgt 131401 caaaattttt atactgatac tgattagcta tgtattctta tgtaatggcc taatgttgga 131461 attaaattta tagaattaaa gacgtgaata tagaaacatg aattctgaat aataaactct 131521 tataagaaga gaagtcatca agctagctga ccctacctgt attttcaagg atatgtgtgg 131581 aacacctgcc atgtgttttg aagtttgtgt tagtattcta aatggctaga cagttgttcc 131641 agtatttgta gttctgatag actaaagttc tgtgaaaaga ggaagagact gtgttttgtt 131701 cattgctgta tttgtagcac ccagcatgct gactaatacc ttttcagtgc acaaaaaata 131761 tattctaagt gaaatttcct tccttattca cagacaatgg tgcagctctt aggagctctc 131821 acaggatgtg ttcagcatat ctgtgccaca caggaatcca tcattttgga aaatattcag 131881 agtctcccct cctcagtcct tcatataatt aaaagcacat ttgtgcattg taaggtgagt 131941 aaaggtctaa ttatactttg aatggtatat aatcaatgtg cataggggct gagtaaaata 132001 atgtttgtat aagattttac attttagtct atattattga aataaacttt tccatagaat 132061 aaagaacatg taagtaaata attgttgcaa aaaaagtggt tttaaggaag tcattaaaag 132121 tggctttttg gggtttttta gttttatctt atttcccctc tataaagaaa gaagttttaa 132181 gaatttgtgt tgagacagac acagggatcc tgaaatagtt atgtcatgtt gcattgacca 132241 atattcaatt accattatga ttagatgtca gaacttcctt ttataaagga aagttaatcc 132301 ttatttagtc catctctaca tgccagaggt agccttgagg cacaaaagct tgcctagaat 132361 ttatgggtca cagacagttt taatattgct atttgttggg cgaatgaaaa tcactagtta 132421 attaatacct ctctttgctg ataggatgct aaaaatgtca cgcacctggc ctaatgttac 132481 ccttttttag ttctgtattt gcaagatcat ggaagtcaga aataatattt tatacatgct 132541 tgcatctctt gaagcacact atatttaatg gatgttcact aaacaatgaa tgaatatgtg 132601 attcagtaaa tttatgatct ctaatagtat gaattaaagt aaatttggct cttgagcttt 132661 gatttgtttt ttctctcatt tttatttatc cgtaatcaga atagtgaatc tgtgtattct 132721 gggtgtttac acctagtttc agaccttctc caggctcttt tcaaggaggc ctattctctt 132781 caaaagcagt taatggaact gctggacatg gtttgcatgg accctttagt agatgacaat 132841 gatgatattt tgaatatggt aataggtgag tgaagaaaac tttctgctta gtatatggtg 132901 actataaatc atgtatcaat taaaattgtc tctaatgatt catgttattt tcttactaat 132961 tatgcattaa aattgattta aatcttacca aataaatttt taatcttgaa atttggaatt 133021 tgtaaaattt attttgggta ccttaaccta gatttgcgta tttagttact gtaatttctc 133081 cacaatgatt aacttatata actttataat ctctgaggtt gtccatattc agagacaata 133141 actttcacat ttttttaacc ataactgata ttgagatgca gtttatattt ccttccagaa 133201 tacatataaa tacgtgcata tgtgtatgta aatatgtcta ttctcatata catattataa 133261 tgaaataact cattttacat gtgatgcact ttatactagt ttatttttat tttattttat 133321 ttttttgaga cagagtctca ctgtgtagcc caggctggag tgcagtggca caatctcggc 133381 tcactgcaac ctcgcctccc ggactcaagc gattctcctg cctcagcctc atgagtagct EPI-109 1002

133441 gggattatag gcgtccgcca ccacacctgg ctaatttttg tatttttagt agagacaggg

133501 tttcaccgtg ttggccaggc tggtcttgaa ctcctgacct caggtaatcc acctgcctca

133561 gcctcccaaa gtgctgggat tacaggcatg agccaccgtg cccagccaat actagtttat

133621 ttttaaagaa ttgctggtcg taacacactt cattgatttt atcactcatt aatggattat

133681 gaacaagagt ttgaaaaaca atataaaggc aaagtttgca ttcaaaactt tggtataaag

133741 agagtaagtt ggttttgtgc agtgtatcag gcacctgttg ctctgcaaca caccacctca

133801 aaatctattt attcactatt tatttattca tgattctgtg agtctgcagt ttagggtggg

133861 atgtcctgag acaactttct ctgatccacc tggggcacta gctcacccat gtgacttcag

133921 tgacttcatt cacatctggc tgttggcaga ggcagaagta cttgagaaag ccatgtgcat

133981 catccagcag gttcacccta tctcagatac ctgatgccag tggtttcagg gtttctaaga

134041 gtagcaaaag tgtgagcagg tcgctgtgtg ctagcacttt tcaagtttct gcttgcctta

134101 attttattat tgtcccccgg gccacagcag gtcatagcgt ttagcccaga gtcattgtag

134161 aaaagtgtgg attcacaaag ggcagtcatt gtggccattt ttataaataa tctaccacag

134221 actgagtaaa agccttgcat gaataccatg gatattaatt tgaattcttc ctttttagat

134281 tttctttcct tagcaatttg ttttgtcatt ttggattaga attatatctg tagaatattt

134341 cagttataat agggtacaac ttttattcca ctgaacatct ttagttttat ttaggtcatc

134401 tggtaggtat aaacttcaga agttaatatt caatatttat aaaaaccatt aacaagtgtg

134461 acacttaaat agtttaaata attcttttga cacaactgtt tccaagttgt gttacgtatt

134521 ttaattcaat caaatgttga aattgttcag tagatagttt taattatagg agaaactcac

134581 ccccatgaca tttggatgtc ttaaaagttc tgttatcttt ctttgcagtt attcattctt

134641 tattggatat ctgctctgtt atttccagta tggaccatgc atttcatgcc aatacttgga

134701 agtttataat taagtaagtt tgtttgttat tttttacttt ttagaaaatg ttttccatat

134761 tccccaatct taattattca tgattcttta gattgcattt aaaacatttt gtgtgaattt

134821 aatgttcact gacactgctg tctgataatc cagatattct acatgtagct ctcaagccaa

134881 attggacttc tttaccctgt ggcctctaaa attaaaaaaa atgttcttcc tagttagcta

134941 gtacttcaga aataatgggc catgggccag actagaactt aaccactttt cttctgctac

135001 tgttgtttaa ccagctatca agtatcctat ttctaggatt agataaattg ataactataa

135061 ttaaaactga atataatctt ttcattaggt acttttaagt tgttcacact taattccatt

135121 tgtacagtaa ttttaacttt ctgaaactga agcattttaa agggtcacca gggatagtgc

135181 ctgtagcatt catcagattc ttaggggtga gaggagatgt ggttgagatg taaaaatggt

135241 taagaatatc tactttatac acatacataa aacattaaag gtcagtgtat tttcaggtct

135301 taggtacttt tcttgtacta ccaggacatt aagttgccat tcagtggtta agagtgttgc

135361 ctgggagctg tatcacatgt gcttaaatcc attcttgaaa tcatttactc cttctgagcc

135421 cttgggctat ttggttaatt tctctgaacg ttagtttgct catctgaaaa tggaaataat

135481 aatagcaact tcttgacagg gttatagtga gaattgagtt catcactgtg aaatgcttag

135541 aaatgtgcat gacacatagt taatactcaa ggaattagcc acatcactat catcatcact

135601 gattatcttc cactcttacc ctcttccagt tcattttctg cccagcagaa tgatctttta

135661 aaaagtaaat cagatcatgt tactctattg cttgaagtct atcccatttg attaagaata

135721 acaacctaat cctctgtgga tgctgcctcc ttcaccagcc tgtctcatgc tgctctccct

135781 actcttagtt cctcaaacat accaaactct cctgtcccag agtcttttcg tggtttttcc

135841 atctgcctag gatgcttctc tctcctattt tgtgtacctt gctaactcct gcttactgtc

135901 tttcagttct cagcttaaga gttatatctt catgataaca ttctttgata tccttaccct

135961 aagattaagt tagattgata tccttaccct aagaataagt tagattaggt ctctctattg

136021 tagcacctta gactctgtca tttgacaaat cacagcccta attaattatt cttaaaatta

136081 tttaacattc tctctcatgc tagaccacaa gtttcatgca ggtaaggcgg agattgtgtc

136141 catttgtttg acccctttgt ctccagggcc tggtagaatg cctcatacat agtaagaatt

136201 caattaatat tttacacaga gaaaaaatta gcaacttatt taaacaaata taactgcttc

136261 agaggtaaac tgggcacatc ttagttatat tatgtgatat atgatgcttt ttgattgttt

136321 ttttaaatgt tctacaaggt agatattgtt agaggtccta agttacttga tgtgttactt

136381 gtggtgattg tattcttttc tttttattca tttaggcaga gccttaagca ccagtccata

136441 ataaaaagcc agttgaaaca caaagatata attactagct tgtgtgaaga cattcttttc

136501 tccttccatt cttgtttaca gttagctgag cagatgacac agtcagatgc acaggtaaaa

136561 tttgggctaa tagcatttta aacagcaact cttattttct ttggcagtta gtaaatctca

136621 tttgaatgtc tgggtcagtc tatttaagag gattttaatt tatttcattt gggtgttttt

136681 ttttgatctg tgggattatt tatatcccat aattactttt cacccagagc attgtattag

136741 attcctaact gctgtcattg cctctggggt ctgcctggct ccctctttgc ttggtaactg

136801 gttggtcaca gcattcttct cagaatcctt tcattctttt ctgcatgaga acaaaaattc

136861 ttttgttcat atttgtataa gatctgatat agctgcaatc aatcttgcat tttttcttca

136921 ccaacgcatt gcgaccttta gggatacaag tatgtttgtg catgtatatg tatgtatcag

136981 tcttttaaat ttgatatagt catacatttg tttttatttt gaaaagttag agtgttgaat

137041 tggtatccca tttatgaaac attatattct aaaaatttgt agtacgatta ttgggaatta

137101 taactcattt tcctgtaaca ctgttataca tagtaccttt tgctttcaga ctagccctca

137161 attttattta actatagtag tcctaaatta taagattaat agtactcagg acctaacagt

137221 tatatgtcat ttgttttttt tttttttgag atggcgtctc actctgtcac ccaagctgga

137281 gtgcagtggt atgaccttgg ctcactgcag cctctgcctc acgggttcaa gggatcgttc

137341 tgccttagcc tcctgagtag ctgggattat aggcgcctgc caccacgcct ggctaatttt

137401 tttagtagag acggggtttc gccatgttgg ccaggctggt ctcgaactcc tgacctcagg

137461 tggtccaccc gccttggcct cccaaagtgc tgggattaca ggtgtgagcc accgcgccca

137521 gcctatatgt aataatttta atgggaccat gaattgaata tttcttcctt gaatagcaat

137581 gacatagccc cttctattgt acatctgcaa gctgatacag ggaattcctt tgtacctgcg

137641 ctcttccctg ccagtcagct atgggggtga aagtgtaggg gttcatccaa gtcctaaaac

137701 tggtagcaac tcctagggca gggctgatct ggaaggacag accctagggg agggtggaac

137761 tttaaaaaga agttctgaag gtagtaagaa ggaaatgagg agtagtgtta ggaaggggct

137821 aacttttttc ttcttgcttc tcttctttat ctcacctgcc cctccccttg tatcccttct

137881 tcctttttcc ctttcctttt ttgtcctcac ttcattcgtg catcctttct gattcctctt EPI-109 1003

137941 accttgctaa aaggagaagt ttgtttgggt atcctatatc aatggcagga aggttgtttt 138001 cttctttacc tttatcctat agattcatat tctcaacacc aacctcctcc tttttcagtt 138061 tccttcttgc ttctcttgac accacagagt ttgcagctag tacttggaga ggaaaattaa 138121 acagagatac ttggaccaag agtaagatga agaaagtcta aacaacagta tagtctatag 138181 tggcaagaga gagtatgggg gctgcttagc cagggtggct gtacataaag tatatcttca 138241 gtttatataa actgcttata gatggaaatc agaaaattta aattctctta actgtccaag 138301 aaaattctca ttttttcaaa tttgggactg ataaatgtga ccagttctgc ttactgtcca 138361 ttgcctgaaa tggagctttg aggtggactg tataatttct tcaatcttaa ctccaaattc 138421 tgatcagcga cgccctctgc tgttcactat taatatttat ttaccaatca aagtaaagta 138481 ttgaagtttt cctggcagtt ttcactttgt gttttagtcc atttaggctg ctataacaaa 138541 atcccttaaa ctgggtaagg gattataaat attagaaatt tatctctcac agttctggaa 138601 gctgggaagc ccaatatcaa ggcaccagta gatttggtgt ctaacgaggg tgtgccgtct 138661 gcttcaaaaa tggccccttg ttgctgcatc ctcacttagt gcaaggggca agacagctcc 138721 cttcaacctc ttttataagg gcacttatgt cattcatgag ggcagagccc tcatgactta 138781 atcacttccc caaaggcccc acctcttaat agtatcacat tgggtgttag gtgtctggga 138841 ggacaccaat cttcaagcca tatcatctca cttggaaaaa agtcaaaata aaaccagtag 138901 atttaattaa tattacacta tttatagaag catgtgatgt atcattcctt gtattaattt 138961 cctggggttg ccgtaacaag ttaccacaaa ctaggtggct taaaacaata gaattttatt 139021 ctctcacatt tctagaggca gaagttcaca gtgtgtcaat agggccatgt tctctggaag 139081 gctttagggg agaatatatt tcatatcttt ctcttagctt ctcggtgtca ctggcaatcc 139141 ttagcttact ttggctttct gtgtcttcac atcatctttt tataagaaca ccagtgatag 139201 tgattaaggg cataccttac tttaatatga cctcatctta actaattatg tcttcaataa 139261 ccctatttcc aaataaggcc acattctgaa gtattgggag ttagaactta aagctttttg 139321 ggagggacac agttcaaccc ataacaaccc ctaaaatcga tatttattct caattaagtc 139381 ttgaaattgg tttcaaaaag agaatattct attagagttt ttaatgtata gttttaacat 139441 atagttcttt agcccccaat tttttttttt tttttttttt tttttttttt tttttgagac 139501 ggagtctcgc tctgtcgccc aggccggact gcggactgca gtggcgcaat ctcggctcac 139561 tgcaagctcc gcttcccggg ttcacgccat tcccctgcct cagcctcccg agtagctggg 139621 actacaggcg cctgccaccg cgcccggcta atttttttgt atttttagta gagacggggt 139681 ttcaccttgt tagccaggat ggtctcgatc tcctgacctc atgatccacc cgcctcggcc 139741 tcccaaagtg ctgggattac aggcgtgagc caccgcgccc ggcctgcccc caattattta 139801 gtttttctat aaacagggaa atttatttgt gtggccctta gaactaattt aatttccact 139861 ctaattccta cttatgttta tataatgctt ttagaaattt gtattattca gaaaataaac 139921 atatactatt gtatctgttg cctacactta gattttattg cctgctatat ttaaatttta 139981 ttagtatttt aattgtttta ttaaagaaag aatgtgcctg taatctcagc acttttgaga 140041 ggccaaggca gaaggattgc ttgagcccag gagtttgaga ccagactgag caacacaggg 140101 agacccccat ctctacaaaa aataaaaaaa ttctccaggc ctcatggcac atacctgtag 140161 ttctagttac ttgggagact ggggtgggag gatgcattga gcccaggaga ttgaggctgc 140221 agtgagccat gatcaggcca ctgtactcca gcttggacaa cagagtgaga gcttgtctag 140281 atagatagat agatagataa tctaaataga taatagacag attatctaaa tagataatag 140341 acagattatc taaatagata atagacagat tatctaaata gataatagac agattatcta 140401 aatagataat agacagatta tctaaataga taatagacag attatctatc taaatagata 140461 atagattatc taaatagata atagatagat agattagata gatagataga tagatagagc 140521 ttggacaaca gagtgagagc ctgtctagat agatagaaac aaagaaagaa agaaagaatg 140581 gtgctcatat tttaaagcat tgaaaaatgg tcttccttgc ttatattacc cacaccttct 140641 ttgttggcat taagatgcaa actttgtttt aaacagttga gtaaatcaaa gatgggactg 140701 ttaagttatt tgtgttattt acctgctttt tgaaaatgta aaaataaaac tctaggttta 140761 attagtagta tgctatttag taatgaagta aagctagagg cttcgaacaa atcttgtgta 140821 atttcctctt gaatgagaga gaaaatttaa agtaagcaaa caaataagtt gtgtgtcacc 140881 actcattcag tcatttaaca agtatttcca gagtacttat tctgtgccag gaaatgttgt 140941 aggtgccctc aacaacttag agtctagcct gagacacaag taagtaggta attattatag 141001 aatggtatga tctttggagg actgggtatt ggctggctca tgggagtaca agataggtac 141061 ccagtgatga agtcaggaaa ggtttcttat ggtgatatga tgacgtctat gctgattata 141121 aggtcagtgt agaataaact ttgtgctttt aaatttgcat agcactgtat tagagagttc 141181 atcttcaaaa taatcgaaaa ggctgagtgt ggtgacccat ggctgtaatc ccagcacttt 141241 gggaggccga ggtgggcaga ttgcttgagc taggagttcg agaccaggct ggccaacatg 141301 gtgaaacccc gtctctacta aaaatacaaa aattagccag gagtgatggt gcgcacctgt 141361 aatgccagct acttgggagg ctgaggcagg aggatcactt gaacccagga ggtggaggtt 141421 gaagtaagcc gaggtcatg.c cactgcactc cagcctgggc aacagagtga gactccatct 141481 caaaaaaaaa aaaaatgatc aaagaaaggt gaattttcat ctaccctatt tctgctgagg 141541 aaaatggact attttcaaat atttttaata agggtcaaaa tgagggatc

(2) INFORMATION FOR SEQ ID NO:2720: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2720

1 atttttttgt agagacaggg tctctctatg ttgcccaggc tggtttcaaa ctcccaggct

61 caagcaatcc tcctgccttg gcctcccaaa gtgctggcat tacaggcgtg agccactgcg

121 cctggcccgt attaatgttt agaacacgaa ttccaggagg caggctaagt ctattcagct

181 tgttcatatg cttgggccaa cccaagaaac aagtgggtga caaatggcac cttttggata

241 gtggtattga ctttgaaagt ttgggtcagg aagctgggga ggaagggtgg gcaggctgtg EPI-109 1004

301 ggcagtcctg ggcggaagac caggcagggc tatgtgctca ctgagcctcc gccctcttcc 361 tttgaatctc tgatagactt ctgcctccta cttctccttt tctgcccttc tttgctttgg 421 tggcttcctt gtggttcctc agtggtgcct gcaacccctg gttcacctcc ttccaggttc 481 tggctccttc cagccatggc tctcagagtc cttctgttaa caggtgcatg ggg

(2) INFORMATION FOR SEQ ID NO: 2721: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2721

1 gaattccgtg gttcctcagt ggtgcctgca acccctggtt cacctccttc caggttctgg

61 ctccttccag ccatggctct cagagtcctt ctgttaacag ccttgacctt atgtcatggg

121 ttcaacttgg acactgaaaa cgcaatgacc ttccaagaga acgcaagggg cttcgggcag

181 agcgtggtcc agcttcaggg atccagggtg gtggttggag ccccccagga gatagtggct

241 gccaaccaaa ggggcagcct ctaccagtgc gactacagca caggctcatg cgagcccatc

301 cgcctgcagg tccccgtgga ggccgtgaac atgtccctgg gcctgtccct ggcagccacc

361 accagccccc ctcagctgct ggcctgtggt cccaccgtgc accagacttg cagtgagaac

421 acgtatgtga aagggctctg cttcctgttt ggatccaacc tacggcagca gccccagaag

481 ttcccagagg ccctccgagg gtgtcctcaa gaggatagtg acattgcctt cttgattgat

541 ggctctggta gcatcatccc acatgacttt cggcggatga aggagtttgt ctcaactgtg

601 atggagcaat taaaaaagtc caaaaccttg ttctctttga tgcagtactc tgaagaattc

661 cggattcact ttaccttcaa agagttccag aacaacccta acccaagatc actggtgaag

721 ccaataacgc agctgcttgg gcggacacac acggccacgg gcatccgcaa agtggtacga

781 gagctgttta acatcaccaa cggagcccga aagaatgcct ttaagatcct agttgtcatc

841 acggatggag aaaagtttgg cgatcccttg ggatatgagg atgtcatccc tgaggcagac

901 agagagggag tcattcgcta cgtcattggg gtgggagatg ccttccgcag tgagaaatcc

961 cgccaagagc ttaataccat cgcatccaag ccgcctcgtg atcacgtgtt ccaggtgaat

1021 aactttgagg ctctgaagac cattcagaac cagcttcggg agaagatctt tgcgatcgag

1081 ggtactcaga caggaagtag cagctccttt gagcatgaga tgtctcagga aggcttcagc

1141 gctgccatca cctctaatgg ccccttgctg agcactgtgg ggagctatga ctgggctggt

1201 ggagtctttc tatatacatc aaaggagaaa agcaccttca tcaacatgac cagagtggat

1261 tcagacatga atgatgctta cttgggttat gctgccgcca tcatcttacg gaaccgggtg

1321 caaagcctgg ttctgggggc acctcgatat cagcacatcg gcctggtagc gatgttcagg

1381 cagaacactg gcatgtggga gtccaacgct aatgtcaagg gcacccagat cggcgcctac

1441 ttcggggcct ccctctgctc cgtggacgtg gacagcaacg gcagcaccga cctggtcctc

1501 atcggggccc cccattacta cgagcagacc cgagggggcc aggtgtccgt gtgccccttg

1561 cccagggggc agagggctcg gtggcagtgt gatgctgttc tctacgggga gcagggccaa

1621 ccctggggcc gctttggggc agccctaaca gtgctggggg acgtaaatgg ggacaagctg

1681 acggacgtgg ccattggggc cccaggagag gaggacaacc ggggtgctgt ttacctgttt

1741 cacggaacct caggatctgg catcagcccc tcccatagcc agcggatagc aggctccaag

1801 ctctctccca ggctccagta ttttggtcag tcactgagtg ggggccagga cctcacaatg

1861 gatggactgg tagacctgac tgtaggagcc caggggcacg tgctgctgct caggtcccag

1921 ccagtactga gagtcaaggc aatcatggag ttcaatccca gggaagtggc aaggaatgta

1981 tttgagtgta atgatcaggt ggtgaaaggc aaggaagccg gagaggtcag agtctgcctc

2041 catgtccaga agagcacacg ggatcggcta agagaaggac agatccagag tgttgtgact

2101 tatgacctgg ctctggactc cggccgccca cattcccgcg ccgtcttcaa tgagacaaag

2161 aacagcacac gcagacagac acaggtcttg gggctgaccc agacttgtga gaccctgaaa

2221 ctacagttgc cgaattgcat cgaggaccca gtgagcccca ttgtgctgcg cctgaacttc

2281 tctctggtgg gaacgccatt gtctgctttc gggaacctcc ggccagtgct ggcggaggat

2341 gctcagagac tcttcacagc cttgtttccc tttgagaaga attgtggcaa tgacaacatc

2401 tgccaggatg acctcagcat caccttcagt ttcatgagcc tggactgcct cgtggtgggt

2461 gggccccggg agttcaacgt gacagtgact gtgagaaatg atggtgagga ctcctacagg

2521 acacaggtca ccttcttctt cccgcttgac ctgtcctacc ggaaggtgtc cacactccag

2581 aaccagcgct cacagcgatc ctggcgcctg gcctgtgagt ctgcctcctc caccgaagtg

2641 tctggggcct tgaagagcac cagctgcagc ataaaccacc ccatcttccc ggaaaactca

2701 gaggtcacct ttaatatcac gtttgatgta gactctaagg cttcccttgg aaacaaactg

2761 ctcctcaagg ccaatgtgac cagtgagaac aacatgccca gaaccaacaa aaccgaattc

2821 caactggagc tgccggtgaa atatgctgtc tacatggtgg tcaccagcca tggggtctcc

2881 actaaatatc tcaacttcac ggcctcagag aataccagtc gggtcatgca gcatcaatat

2941 caggtcagca acctggggca gaggagcctc cccatcagcc tggtgttctt ggtgcccgtc

3001 cggctgaacc agactgtcat atgggaccgc ccccaggtca ccttctccga gaacctctcg

3061 agtacgtgcc acaccaagga gcgcttgccc tctcactccg actttctggc tgagcttcgg

3121 aaggcccccg tggtgaactg ctccatcgct gtctgccaga gaatccagtg tgacatcccg

3181 ttctttggca tccaggaaga attcaatgct accctcaaag gcaacctctc gtttgactgg

3241 tacatcaaga cctcgcataa ccacctcctg atcgtgagca cagctgagat cttgtttaac

3301 gattccgtgt tcaccctgct gccgggacag ggggcgtttg tgaggtccca gacggagacc

3361 aaagtggagc cgttcgaggt ccccaacccc ctgccgctca tcgtgggcag ctctgtcggg EPI-109 1005

3421 ggactgctgc tcctggccct catcaccgcc gcgctgtaca agctcggctt cttcaagcgg

3481 caatacaagg acatgatgag tgaagggggt cccccggggg ccgaacccca gtagcggctc

3541 cttcccgaca gagctgcctc tcggtggcca gcaggactct gcccagacca cacgtagccc

3601 ccaggctgct ggacacgtcg gacagcgaag tatccccgac aggacgggct tgggcttcca

3661 tttgtgtgtg tgcaagtgtg tatgtgcgtg tgtgcgagtg tgtgcaagtg tctgtgtgca

3721 agtgtgtgca cgtgtgcgtg tgcgtgcatg tgcactcgca cgcccatgtg tgagtgtgtg

3781 caagtatgtg agtgtgtcca gtgtgtgtgc gtgtgtccat gtgtgtgcag tgtgtgcatg

3841 tgtgcgagtg tgtgcatgtg tgtgctcagg ggctgtggct cacgtgtgtg actcagagtg

3901 tctctggcgt gtgggtaggt gacggcagcg tagcctctcc ggcagaaggg aactgcctgg 3961 gctcccttgt gcgtgggtaa gccgctgctg ggttttcctc cgggagaggg gacggtcaat 4021 cctgtgggtg aagagagagg gaaacacagc agcatctctc cactgaaaga agtgggactt 4081 cccgtcgcct gcgagcctgc ggcctgctgg agcctgcgca gcttggatgg atactccatg 4141 agaaaagccg tgggtggaac caggagcctc ctccacacca gcgctgatgc ccaataaaga 4201 tgcccactga ggaatcatga agcttccttt ctggattcat ttattatttc aatgtgactt 4261 taattttttg gatggataag cctgtctatg gtacaaaaat cacaaggcat tcaagtgtac 4321 agtgaaaagt ctccctttcc agatattcaa gtcacctcct taaaggtagt caagattgtg 4381 ttttgaggtt tccttcagac agattccagg cgatgtgcaa gtgtatgcac gtgtgcacac 4441 accacacaca tacacacaca caagcttttt tacacaaatg gtagcatact ttatattggt

4501 ctgtatcttg ctttttttca ccaatatttc tcagacatcg gttcatatta agacataaat 4561 tactttttca ttcttttata ccgctgcata gtattccatt gtgtgagtgt accataatgt 4621 atttaaccag tcttcttttg atatactatt ttcatctctt gttattgcat ctgctgagtt 4681 aataaatcaa atatatgtca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

(2) INFORMATION FOR SEQ ID NO: 2722: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2722

1 ggttcaagtg attctgctgc ctcagcctcc caggcgggat tacaggtgcc tgccaccacg

61 cctggctaat ttttttgtct ttttagtaaa gatgaggttt caccatgttg ggcaggctgg

121 tttcaattgc tgacctcaag tgagccaccc cgcctcagcc tccaaaatgc taggattaca

181 ggcatgagcc accgcaccca gccaagtttg tacatatatt tttgactaca cttcttaact

241 attcttagga taaattacta gaagtgaaaa ttcttgggtg aagagcttga ggcctttaca

301 cacacacaca cacacacaca cacacacaca caaataggct ggatcgagtg gctcacacct

361 gtaatctcag cagtttggga ggctgaggaa ggaggatcac ttgagtccag gaggttgaga

421 atagcctgaa caacatagca agatcttgtc tctacaaaaa agtttaaaaa aaattagctg

481 gccatggcag catgtgcctg tagtaccagc tactcggaag gctgaggtag gaggatcgct

541 tgagcccagg aggtgattga agctgcagtg agctgtgatt acaccactgc actccagcct

601 gggcaacaga gctagactct gtctctaaaa aaaggcacaa aataatattt aaaaagcacc

661 aggtatgcct gtacttgagt tgtctttgtt gatggctaca aatgagacag ctctggctga

721 agggcggctt ccatttccat gggctggagg aggacatttt gcaaagtgtg ttttcaggaa

781 gacacagagt tttacctcct acacttgttt gatctgtatt aatgtttgct tatttattta

841 tttaattttt tttttgagac agagtctcac tctgtcacct gggctggagt gcagtggcat

901 tattgaggct cattgcagtc tcagactcct gagctcaaac aatcctcctg cctcagcctc

961 tggagtagct aggactacag gcatgtgcca ccatgcctgg ctaatttttt aaatgtattt

1021 ttttgtagag tcggggtctc cctatgttgc ccaggctgga gtgcagtggt gtgatcctag

1081 ctcactgcag cctggacctc gggctcaaga aattctcaca cctcagcctg tccagtagca

1141 ggggctacag gcgcgcacca ccatcccagc taattaaaaa tatttttttg tagagacagg

1201 gtctctctat gttgcccagg ctggtttcaa actcccaggc tcaagcaatc ctcctgcctt

1261 gcctcccaaa tgacatcgga ttacaggcgt gagccactga gcctggcccg tattaatgtt

1321 tagaacacga attccaggag gcaggctaag tctattcagc ttgttcatat gcttgggcca

1381 acccaagaaa caagtgggtg acaaatggca ccttttggat agtggtattg actttgaaag

1441 tttgggtcag gagctgggga ggaagggtgg gcaggctgtg ggcagtcctg ggcggaagac

1501 caggcagggc tatgtgctca ctgagcctcc gccctcttcc tttgaatctc tgatagactt

1561 ctgcctccta cttctccttt tctgcccttc tttgctttgg tggcttcctt gtggttcctc

1621 agtggtgcct gcaaccctgg ttcactcttc caggttctgg ctccttccag ccatggctct

1681 cagagtcctt ctgttaacag gtgcatgggg gtggggtggg ggactctggg tggggaggag

1741 ggtaactttt gggtctgtca taaatagagg gccc

(2) INFORMATION FOR SEQ ID NO:2723: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2723 1 atttttttgt agagacaggg tctctctatg ttgcccaggc tggtttcaaa ctcccaggct EPI-109 1006

61 caagcaatcc tcctgccttg gcctcccaaa gtgctggcat tacaggcgtg agccactgcg 121 cctggcccgt attaatgttt agaacacgaa ttccaggagg caggctaagt ctattcagct 181 tgttcatatg cttgggccaa cccaagaaac aagtgggtga caaatggcac cttttggata 241 gtggtattga ctttgaaagt ttgggtcagg aagctgggga ggaagggtgg gcaggctgtg 301 ggcagtcctg ggcggaagac caggcagggc tatgtgctca ctgagcctcc gccctcttcc 361 tttgaatctc tgatagactt ctgcctccta cttctccttt tctgcccttc tttgctttgg 421 tggcttcctt gtggttcctc agtggtgcct gcaacccctg gttcacctcc ttccaggttc 481 tggctccttc cagccatggc tctcagagtc cttctgttaa caggtgcatg ggg

1 gaattccgtg gttcctcagt ggtgcctgca acccctggtt cacctccttc caggttctgg

61 ctccttccag ccatggctct cagagtcctt ctgttaacag ccttgacctt atgtcatggg

121 ttcaacttgg acactgaaaa cgcaatgacc ttccaagaga acgcaagggg cttcgggcag

181 agcgtggtcc agcttcaggg atccagggtg gtggttggag ccccccagga gatagtggct

241 gccaaccaaa ggggcagcct ctaccagtgc gactacagca caggctcatg cgagcccatc

301 cgcctgcagg tccccgtgga ggccgtgaac atgtccctgg gcctgtccct ggcagccacc

361 accagccccc ctcagctgct ggcctgtggt cccaccgtgc accagacttg cagtgagaac

421 acgtatgtga aagggctctg cttcctgttt ggatccaacc tacggcagca gccccagaag

481 ttcccagagg ccctccgagg gtgtcctcaa gaggatagtg acattgcctt cttgattgat

541 ggctctggta gcatcatccc acatgacttt cggcggatga aggagtttgt ctcaactgtg

601 atggagcaat taaaaaagtc caaaaccttg ttctctttga tgcagtactc tgaagaattc

661 cggattcact ttaccttcaa agagttccag aacaacccta acccaagatc actggtgaag

721 ccaataacgc agctgcttgg gcggacacac acggccacgg gcatccgcaa agtggtacga

781 gagctgttta acatcaccaa cggagcccga aagaatgcct ttaagatcct agttgtcatc

841 acggatggag aaaagtttgg cgatcccttg ggatatgagg atgtcatccc tgaggcagac

901 agagagggag tcattcgcta cgtcattggg gtgggagatg ccttccgcag tgagaaatcc

961 cgccaagagc ttaataccat cgcatccaag ccgcctcgtg atcacgtgtt ccaggtgaat

1021 aactttgagg ctctgaagac cattcagaac cagcttcggg agaagatctt tgcgatcgag

1081 ggtactcaga caggaagtag cagctccttt gagcatgaga tgtctcagga aggcttcagc

1141 gctgccatca cctctaatgg ccccttgctg agcactgtgg ggagctatga ctgggctggt

1201 ggagtctttc tatatacatc aaaggagaaa agcaccttca tcaacatgac cagagtggat

1261 tcagacatga atgatgctta cttgggttat gctgccgcca tcatcttacg gaaccgggtg

1321 caaagcctgg ttctgggggc acctcgatat cagcacatcg gcctggtagc gatgttcagg

1381 cagaacactg gcatgtggga gtccaacgct aatgtcaagg gcacccagat cggcgcctac

1441 ttcggggcct ccctctgctc cgtggacgtg gacagcaacg gcagcaccga cctggtcctc

1501 atcggggccc cccattacta cgagcagacc cgagggggcc aggtgtccgt gtgccccttg

1561 cccagggggc agagggctcg gtggcagtgt gatgctgttc tctacgggga gcagggccaa

1621 ccctggggcc gctttggggc agccctaaca gtgctggggg acgtaaatgg ggacaagctg

1681 acggacgtgg ccattggggc cccaggagag gaggacaacc ggggtgctgt ttacctgttt

1741 cacggaacct caggatctgg catcagcccc tcccatagcc agcggatagc aggctccaag

1801 ctctctccca ggctccagta ttttggtcag tcactgagtg ggggccagga cctcacaatg

1861 gatggactgg tagacctgac tgtaggagcc caggggcacg tgctgctgct caggtcccag

1921 ccagtactga gagtcaaggc aatcatggag ttcaatccca gggaagtggc aaggaatgta

1981 tttgagtgta atgatcaggt ggtgaaaggc aaggaagccg gagaggtcag agtctgcctc

2041 catgtccaga agagcacacg ggatcggcta agagaaggac agatccagag tgttgtgact

2101 tatgacctgg ctctggactc cggccgccca cattcccgcg ccgtcttcaa tgagacaaag

2161 aacagcacac gcagacagac acaggtcttg gggctgaccc agacttgtga gaccctgaaa

2221 ctacagttgc cgaattgcat cgaggaccca gtgagcccca ttgtgctgcg cctgaacttc

2281 tctctggtgg gaacgccatt gtctgctttc gggaacctcc ggccagtgct ggcggaggat

2341 gctcagagac tcttcacagc cttgtttccc tttgagaaga attgtggcaa tgacaacatc

2401 tgccaggatg acctcagcat caccttcagt ttcatgagcc tggactgcct cgtggtgggt

2461 gggccccggg agttcaacgt gacagtgact gtgagaaatg atggtgagga ctcctacagg

2521 acacaggtca ccttcttctt cccgcttgac ctgtcctacc ggaaggtgtc cacactccag

2581 aaccagcgct cacagcgatc ctggcgcctg gcctgtgagt ctgcctcctc caccgaagtg

2641 tctggggcct tgaagagcac cagctgcagc ataaaccacc ccatcttccc ggaaaactca

2701 gaggtcacct ttaatatcac gtttgatgta gactctaagg cttcccttgg aaacaaactg

2761 ctcctcaagg ccaatgtgac cagtgagaac aacatgccca gaaccaacaa aaccgaattc

2821 caactggagc tgccggtgaa atatgctgtc tacatggtgg tcaccagcca tggggtctcc

2881 actaaatatc tcaacttcac ggcctcagag aataccagtc gggtcatgca gcatcaatat

2941 caggtcagca acctggggca gaggagcctc cccatcagcc tggtgttctt ggtgcccgtc

3001 cggctgaacc agactgtcat atgggaccgc ccccaggtca ccttctccga gaacctctcg

3061 agtacgtgcc acaccaagga gcgcttgccc tctcactccg actttctggc tgagcttcgg

3121 aaggcccccg tggtgaactg ctccatcgct gtctgccaga gaatccagtg tgacatcccg

3181 ttctttggca tccaggaaga attcaatgct accctcaaag gcaacctctc gtttgactgg

3241 tacatcaaga cctcgcataa ccacctcctg atcgtgagca cagctgagat cttgtttaac

3301 gattccgtgt tcaccctgct gccgggacag ggggcgtttg tgaggtccca gacggagacc

3361 aaagtggagc cgttcgaggt ccccaacccc ctgccgctca tcgtgggcag ctctgtcggg

3421 ggactgctgc tcctggccct catcaccgcc gcgctgtaca agctcggctt cttcaagcgg

3481 caatacaagg acatgatgag tgaagggggt cccccggggg ccgaacccca gtagcggctc

3541 cttcccgaca gagctgcctc tcggtggcca gcaggactct gcccagacca cacgtagccc EPI-109 1007

3601 ccaggctgct ggacacgtcg gacagcgaag tatccccgac aggacgggct tgggcttcca

3661 tttgtgtgtg tgcaagtgtg tatgtgcgtg tgtgcgagtg tgtgcaagtg tctgtgtgca

3721 agtgtgtgca cgtgtgcgtg tgcgtgcatg tgcactcgca cgcccatgtg tgagtgtgtg

3781 caagtatgtg agtgtgtcca gtgtgtgtgc gtgtgtccat gtgtgtgcag tgtgtgcatg

3841 tgtgcgagtg tgtgcatgtg tgtgctcagg ggctgtggct cacgtgtgtg actcagagtg

3901 tctctggcgt gtgggtaggt gacggcagcg tagcctctcc ggcagaaggg aactgcctgg

3961 gctcccttgt gcgtgggtaa gccgctgctg ggttttcctc cgggagaggg gacggtcaat

4021 cctgtgggtg aagagagagg gaaacacagc agcatctctc cactgaaaga agtgggactt

4081 cccgtcgcct gcgagcctgc ggcctgctgg agcctgcgca gcttggatgg atactccatg

4141 agaaaagccg tgggtggaac caggagcctc ctccacacca gcgctgatgc ccaataaaga

4201 tgcccactga ggaatcatga agcttccttt ctggattcat ttattatttc aatgtgactt

4261 taattttttg gatggataag cctgtctatg gtacaaaaat cacaaggcat tcaagtgtac

4321 agtgaaaagt ctccctttcc agatattcaa gtcacctcct taaaggtagt caagattgtg

4381 ttttgaggtt tccttcagac agattccagg cgatgtgcaa gtgtatgcac gtgtgcacac

4441 accacacaca tacacacaca caagcttttt tacacaaatg gtagcatact ttatattggt

4501 ctgtatcttg ctttttttca ccaatatttc tcagacatcg gttcatatta agacataaat

4561 tactttttca ttcttttata ccgctgcata gtattccatt gtgtgagtgt accataatgt

4621 atttaaccag tcttcttttg atatactatt ttcatctctt gttattgcat ctgctgagtt

4681 aataaatcaa atatatgtca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

1 ggttcaagtg attctgctgc ctcagcctcc caggcgggat tacaggtgcc tgccaccacg

61 cctggctaat ttttttgtct ttttagtaaa gatgaggttt caccatgttg ggcaggctgg

121 tttcaattgc tgacctcaag tgagccaccc cgcctcagcc tccaaaatgc taggattaca

181 ggcatgagcc accgcaccca gccaagtttg tacatatatt tttgactaca cttcttaact

241 attcttagga taaattacta gaagtgaaaa ttcttgggtg aagagcttga ggcctttaca

301 cacacacaca cacacacaca cacacacaca caaataggct ggatcgagtg gctcacacct

361 gtaatctcag cagtttggga ggctgaggaa ggaggatcac ttgagtccag gaggttgaga

421 atagcctgaa caacatagca agatcttgtc tctacaaaaa agtttaaaaa aaattagctg

481 gccatggcag catgtgcctg tagtaccagc tactcggaag gctgaggtag gaggatcgct

541 tgagcccagg aggtgattga agctgcagtg agctgtgatt acaccactgc actccagcct

601 gggcaacaga gctagactct gtctctaaaa aaaggcacaa aataatattt aaaaagcacc

661 aggtatgcct gtacttgagt tgtctttgtt gatggctaca aatgagacag ctctggctga

721 agggcggctt ccatttccat gggctggagg aggacatttt gcaaagtgtg ttttcaggaa

781 gacacagagt tttacctcct acacttgttt gatctgtatt aatgtttgct tatttattta

841 tttaattttt tttttgagac agagtctcac tctgtcacct gggctggagt gcagtggcat

901 tattgaggct cattgcagtc tcagactcct gagctcaaac aatcctcctg cctcagcctc

961 tggagtagct aggactacag gcatgtgcca ccatgcctgg ctaatttttt aaatgtattt

1021 ttttgtagag tcggggtctc cctatgttgc ccaggctgga gtgcagtggt gtgatcctag

1081 ctcactgcag cctggacctc gggctcaaga aattctcaca cctcagcctg tccagtagca

1141 ggggctacag gcgcgcacca ccatcccagc taattaaaaa tatttttttg tagagacagg

1201 gtctctctat gttgcccagg ctggtttcaa actcccaggc tcaagcaatc ctcctgcctt

1261 gcctcccaaa tgacatcgga ttacaggcgt gagccactga gcctggcccg tattaatgtt

1321 tagaacacga attccaggag gcaggctaag tctattcagc ttgttcatat gcttgggcca

1381 acccaagaaa caagtgggtg acaaatggca ccttttggat agtggtattg actttgaaag

1441 tttgggtcag gagctgggga ggaagggtgg gcaggctgtg ggcagtcctg ggcggaagac

1501 caggcagggc tatgtgctca ctgagcctcc gccctcttcc tttgaatctc tgatagactt

1561 ctgcctccta cttctccttt tctgcccttc tttgctttgg tggcttcctt gtggttcctc

1621 agtggtgcct gcaaccctgg ttcactcttc caggttctgg ctccttccag ccatggctct

1681 cagagtcctt ctgttaacag gtgcatgggg gtggggtggg ggactctggg tggggaggag

1741 ggtaactttt gggtctgtca taaatagagg gccc

(2) INFORMATION FOR SEQ ID NO: 2724: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2724

1 ctgcagctcc ggaacggggg ggggctgctc tccaccgccc ctgtgcggcc gcccgggaaa

61 gtgcaggcgg gccgggcgcg gtggctcacg cctgtgatct cagcactttg ggaggccgag

121 gtgggcggat cacctgaggt cgggagttcg aggccagcct gcccaacatg gagaaaccct

181 gtctctacta aagatacaaa attagccagg cgtggtgacg catgcctgta atcccagcta

241 ctggagtggc tgaggcagga gaatcgcttg agcccgggag acagaggttg cggtgagctg

301 agatcgcacc attgcactcc agcctgggca acaagagcga aactcagaaa aaaaagaaaa

361 gaaagtgcag gggacccgcc gtcggggtgg gggcggcgct gcccagcctc tgtcccactt

421 ccatgcactt gacctcgacc ctccggcctc cgtctgcgat cttcccgtgc ctgaatatga

481 ggcttggaac agacccagac cttcctgcct gcccgtcctg agtggccccg ggaccccgcc

541 ccatctttgg cccccagccc ctgcctctct gccgcctcca gggtcggggg tcaggccagg

601 aaagcccctt gggaagcccc cggggagcag ctggagcggg gtcgccgggc ggcgggaagg

661 agtgggcgcc tctatttaag cggcttcccc gcggcctcgg gacagagggg actgagcatg EPI-109 1008

721 gatttcggac tggccctcct gctggcgggg cttctggggc tcctcctcgg tgagaaggg

(2) INFORMATION FOR SEQ ID NO:2725: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2725

1 atggatttcg gactggccct cctgctggcg gggcttctgg ggctcctcct cggccagtcc

61 ctccaggtga agcccctgca ggtggagccc ccggagccgg tggtggccgt ggccttgggc

121 gcctcgcgcc agctcacctg ccgcctggcc tgcgcggacc gcggggcctc ggtgcagtgg

181 cggggcctgg acaccagcct gggcgcggtg cagtcggaca cgggccgcag cgtcctcacc

241 gtgcgcaacg cctcgctgtc ggcggccggg acccgcgtgt gcgtgggctc ctgcgggggc

301 cgcaccttcc agcacaccgt gcagctcctt gtgtacgcct tcccggacca gctgaccgtc

361 tccccagcag ccctggtgcc tggtgacccg gaggtggcct gtacggccca caaagtcacg

421 cccgtggacc ccaacgcgct ctccttctcc ctgctcgtcg ggggccagga actggagggg

481 gcgcaagccc tgggcccgga ggtgcaggag gaggaggagg agccccaggg ggacgaggac

541 gtgctgttca gggtgacaga gcgctggcgg ctgccgcccc tggggacccc tgtcccgccc

601 gccctctact gccaggccac gatgaggctg cctggcttgg agctcagcca ccgccaggcc

661 atccccgtcc tgcacagccc gacctccccg gagcctcccg acaccacctc cccggagcct

721 cccaacacca cctccccgga gtctcccgac accacctccc cggagtctcc cgacaccacc

781 tcccaggagc ctcccgacac cacctcccag gagcctcccg acaccacctc ccaggagcct

841 cccgacacca cctccccgga gcctcccgac aagacctccc cggagcccgc cccccagcag

901 ggctccacac acacccccag gagcccaggc tccaccagga ctcgccgccc tgagatctcc

961 caggctgggc ccacgcaggg agaagtgatc ccaacaggct cgtccaaacc tgcgggtgac

1021 cagctgcccg cggctctgtg gaccagcagt gcggtgctgg gactgctgct cctggccttg

1081 cccacgtatc acctctggaa acgctgccgg cacctggctg aggacgacac ccacccacca

1141 gcttctctga ggcttctgcc ccaggtgtcg gcctgggctg ggttaagggg gaccggccag

1201 gtcgggatca gcccctcctg agtggccagc ctttccccct gtgaaagcaa aatagcttgg

1261 accccttcaa gttgagaact ggtcagggca aacctgcctc ccattctact caaagtcatc

1321 cctctgctca cagagatgga tgcatgttct gattgcctct ttggagaagc tcatcagaaa

1381 ctcaaaagaa ggccactgtt tgtctcacct acccatgacc tgaagcccct ccctgagtgg

1441 tccccacctt tctggacgga accacgtact ttttacatac attgattcat gtctcacgtc

1501 tccctaaaaa tgcgtaagac caagctgtgc cctgaccacc ctgggcccct gtcgtcagga

1561 cctcctgagg ctttggcaaa taaacctcct aaaatgat

(2) INFORMATION FOR SEQ ID NO:2726: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2726

1 tccatcacag ccttcccgga ccagctgacc gtctccccag cagccctggt gcctggtgac

61 ccggaggtgg cctgtacggc ccacaaagtc acgcccgtgg accccaacgc gctctccttc

121 tccctgctcg tcgggggcca ggaactggag ggggcgcaag ccctgggccc ggaggtgcag

181 gaggaggagg aggagcccca gggggacgag gacgtgctgt tcagggtgac agagcgctgg

241 cggctgccgc ccctggggac ccctgtcccg cccgccctct actgccaggc cacgatgagg

301 ctgcctggct tggagctcag ccaccgccag gccatccccg gtgagtccgc

(2) INFORMATION FOR SEQ ID NO: 2727: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2727

1 gtcgccgcag gccagtccct ccaggtgaag cccctgcagg tggagccccc ggagccggtg 61 gtggccgtgg ccttgggcgc ctcgcgccag ctcacctgcc gcctggcctg cgcggaccgc 121 ggggcctcgg tgcagtggcg gggcctggac accagcctgg gcgcggtgca gtcggacacg 181 ggccgcagcg tcctcaccgt gcgcaacgcc tcgctgtcgg cggccgggac ccgcgtgtgc 241 gtgggctcct gcgggggccg caccttccag cacaccgtgc agctccttgt gtacggtgag 301 gcgtc

(2) INFORMATION FOR SEQ ID NO:2728: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single EPI-109 1009

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2728

1 ctgtttccag tcctgcacag cccgacctcc ccggagcctc ccgacaccac ctccccggag 61 cctcccaaca ccacctcccc ggagtctccc gacaccacct ccccggagtc tcccgacacc 121 acctcccagg agcctcccga caccacctcc caggagcctc ccgacaccac ctcccaggag 181 cctcccgaca ccacctcccc ggagcctccc gacaagacct ccccggagcc cgccccccag 241 cagggctcca cacacacccc caggagccca ggctccacca ggactcgccg ccctgagatc 301 tcccaggctg ggcccacgca gggagaagtg atcccaacag gctgtgagtt ctg

(2) INFORMATION FOR SEQ ID NO: 2729: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2729

1 ctctccccag cgtccaaacc tgcgggtgac cagctgcccg cggctctgtg gaccagcagt 61 gcggtgctgg gactgctgct cctggccttg cccacgtatc acctctggaa acgctgccgg 121 cacctggctg aggacgacac ccacccacca gcttctctga ggcttctgcc ccaggtgtcg 181 gcctgggctg ggttaagggg gaccggccag gtcgggatca gcccctcctg agtggccagc 241 ctttccccct gtgaaagcaa aatagcttgg accccttcaa gttgagaact ggtcagggca 301 aacctgcctc ccattctact caaagtcatc cctctgttca cagagatgga tgcatgttct 361 gattgcctct ttggagaagc tcatcagaaa ctcaaaagaa ggccactgtt tgtctcacct 421 acccatgacc tgaagcccct ccctgagtgg tccccacctt tctggacgga accacgtact 481 ttttacatac attgattcat gtctcacgtc tccctaaaaa tgcgtaagac caagctgtgc 541 cctgaccacc ctgggcccct gtcgtcagga cctcctgagg ctttggcaaa taaacctcct 601 aaaatgat

(2) INFORMATION FOR SEQ ID NO:2730: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2730

1 gggactgagc atggatttcg gactggccct cctgctggcg gggcttctgg ggctcctcct

61 cggccagtcc ctccaggtga agcccctgca ggtggagccc ccggagccgg tggtggccgt

121 ggccttgggc gcctcgcgcc agctcacctg ccgcctggcc tgcgcggacc gcggggcctc

181 ggtgcagtgg cggggcctgg acaccagcct gggcgcggtg cagtcggaca cgggccgcag

241 cgtcctcacc gtgcgcaacg cctcgctgtc ggcggccggg acccgcgtgt gcgtgggctc

301 ctgcgggggc cgcaccttcc agcacaccgt gcagctcctt gtgtacgcct tcccggacca

361 gctgaccgtc tccccagcag ccctggtgcc tggtgacccg gaggtggcct gtacggccca

421 caaagtcacg cccgtggacc ccaacgcgct ctccttctcc ctgctcgtcg ggggccagga

481 actggagggg gcgcaagccc tgggcccgga ggtgcaggag gaggaggagg agccccaggg

541 ggacgaggac gtgctgttca gggtgacaga gcgctggcgg ctgccgcccc tggggacccc

601 tgtcccgccc gccctctact gccaggccac gatgaggctg cctggcttgg agctcagcca

661 ccgccaggcc atccccgtcc tgcacagccc gacctccccg gagcctcccg acaccacctc

721 cccggagtct cccgacacca cctccccgga gtctcccgac accacctccc cggagcctcc

781 cgacaccacc tccccggagc ctcccgacaa gacctccccg gagcccgccc cccagcaggg

841 ctccacacac acccccagga gcccaggctc caccaggact cgccgccctg agatctccca

901 ggctgggccc acgcagggag aagtgatccc aacaggctcg tccaaacctg cgggtgacca

961 gctgcccgcg gctctgtgga ccagcagtgc ggtgctggga ctgctgctcc tggccttgcc

1021 cacgtatcac ctctggaaac gctgccggca cctggctgag gacgacaccc acccaccagc

1081 ttctctgagg cttctgcccc aggtgtcggc ctgggctggg ttaaggggga ccggccaggt

1141 cgggatcagc ccctcctgag tggccagcct ttccccctgt gaaagcaaaa tagcttggac

1201 cccttcaagt tgagaactgg tcagggcaaa cctgcctccc attctactca aagtcatccc

1261 tctgttcaca gagatggatg catgttctga ttgcctcttt ggagaagctc atcagaaact

1321 caaaagaagg ccactgtttg tctcacctac ccatgacctg aagcccctcc ctgagtggtc

1381 cccacctttc tggacggaac cacgtacttt ttacatacat tgattcatgt ctcacgtctc

1441 cctaaaaatg cgtaagacca agctgtgccc tgaccaccct gggcccctgt cgtcaggacc

1501 tcctgaggct ttggcaaata aacctcctaa aatgataaaa aaaaaa

(2) INFORMATION FOR SEQ ID NO: 2731: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2731 1 ctgcagctcc ggaacggggg ggggctgctc tccaccgccc ctgtgcggcc gcccgggaaa EPI-109 1010

61 gtgcaggcgg gccgggcgcg gtggctcacg cctgtgatct cagcactttg ggaggccgag

121 gtgggcggat cacctgaggt cgggagttcg aggccagcct gcccaacatg gagaaaccct

181 gtctctacta aagatacaaa attagccagg cgtggtgacg catgcctgta atcccagcta

241 ctggagtggc tgaggcagga gaatcgcttg agcccgggag acagaggttg cggtgagctg

301 agatcgcacc attgcactcc agcctgggca acaagagcga aactcagaaa aaaaagaaaa

361 gaaagtgcag gggacccgcc gtcggggtgg gggcggcgct gcccagcctc tgtcccactt 421 ccatgcactt gacctcgacc ctccggcctc cgtctgcgat cttcccgtgc ctgaatatga 481 ggcttggaac agacccagac cttcctgcct gcccgtcctg agtggccccg ggaccccgcc 541 ccatctttgg cccccagccc ctgcctctct gccgcctcca gggtcggggg tcaggccagg 601 aaagcccctt gggaagcccc cggggagcag ctggagcggg gtcgccgggc ggcgggaagg 661 agtgggcgcc tctatttaag cggcttcccc gcggcctcgg gacagagggg actgagcatg 721 gatttcggac tggccctcct gctggcgggg cttctggggc tcctcctcgg tgagaaggg

1 atggatttcg gactggccct cctgctggcg gggcttctgg ggctcctcct cggccagtcc

61 ctccaggtga agcccctgca ggtggagccc ccggagccgg tggtggccgt ggccttgggc

121 gcctcgcgcc agctcacctg ccgcctggcc tgcgcggacc gcggggcctc ggtgcagtgg

181 cggggcctgg acaccagcct gggcgcggtg cagtcggaca cgggccgcag cgtcctcacc

241 gtgcgcaacg cctcgctgtc ggcggccggg acccgcgtgt gcgtgggctc ctgcgggggc

301 cgcaccttcc agcacaccgt gcagctcctt gtgtacgcct tcccggacca gctgaccgtc

361 tccccagcag ccctggtgcc tggtgacccg gaggtggcct gtacggccca caaagtcacg

421 cccgtggacc ccaacgcgct ctccttctcc ctgctcgtcg ggggccagga actggagggg

481 gcgcaagccc tgggcccgga ggtgcaggag gaggaggagg agccccaggg ggacgaggac 541 gtgctgttca gggtgacaga gcgctggcgg ctgccgcccc tggggacccc tgtcccgccc 601 gccctctact gccaggccac gatgaggctg cctggcttgg agctcagcca ccgccaggcc 661 atccccgtcc tgcacagccc gacctccccg gagcctcccg acaccacctc cccggagcct 721 cccaacacca cctccccgga gtctcccgac accacctccc cggagtctcc cgacaccacc 781 tcccaggagc ctcccgacac cacctcccag gagcctcccg acaccacctc ccaggagcct 841 cccgacacca cctccccgga gcctcccgac aagacctccc cggagcccgc cccccagcag 901 ggctccacac acacccccag gagcccaggc tccaccagga ctcgccgccc tgagatctcc 961 caggctgggc ccacgcaggg agaagtgatc ccaacaggct cgtccaaacc tgcgggtgac

1021 cagctgcccg cggctctgtg gaccagcagt gcggtgctgg gactgctgct cctggccttg

1081 cccacgtatc acctctggaa acgctgccgg cacctggctg aggacgacac ccacccacca

1141 gcttctctga ggcttctgcc ccaggtgtcg gcctgggctg ggttaagggg gaccggccag

1201 gtcgggatca gcccctcctg agtggccagc ctttccccct gtgaaagcaa aatagcttgg

1261 accccttcaa gttgagaact ggtcagggca aacctgcctc ccattctact caaagtcatc

1321 cctctgctca cagagatgga tgcatgttct gattgcctct ttggagaagc tcatcagaaa

1381 ctcaaaagaa ggccactgtt tgtctcacct acccatgacc tgaagcccct ccctgagtgg

1441 tccccacctt tctggacgga accacgtact ttttacatac attgattcat gtctcacgtc

1501 tccctaaaaa tgcgtaagac caagctgtgc cctgaccacc ctgggcccct gtcgtcagga

1561 cctcctgagg ctttggcaaa taaacctcct aaaatgat

1 tccatcacag ccttcccgga ccagctgacc gtctccccag cagccctggt gcctggtgac

61 ccggaggtgg cctgtacggc ccacaaagtc acgcccgtgg accccaacgc gctctccttc

121 tccctgctcg tcgggggcca ggaactggag ggggcgcaag ccctgggccc ggaggtgcag

181 gaggaggagg aggagcccca gggggacgag gacgtgctgt tcagggtgac agagcgctgg

241 cggctgccgc ccctggggac ccctgtcccg cccgccctct actgccaggc cacgatgagg

301 ctgcctggct tggagctcag ccaccgccag gccatccccg gtgagtccgc

1 gtcgccgcag gccagtccct ccaggtgaag cccctgcagg tggagccccc ggagccggtg

61 gtggccgtgg ccttgggcgc ctcgcgccag ctcacctgcc gcctggcctg cgcggaccgc

121 ggggcctcgg tgcagtggcg gggcctggac accagcctgg gcgcggtgca gtcggacacg

181 ggccgcagcg tcctcaccgt gcgcaacgcc tcgctgtcgg cggccgggac ccgcgtgtgc

241 gtgggctcct gcgggggccg caccttccag cacaccgtgc agctccttgt gtacggtgag

301 gcgtc

1 ctgtttccag tcctgcacag cccgacctcc ccggagcctc ccgacaccac ctccccggag

61 cctcccaaca ccacctcccc ggagtctccc gacaccacct ccccggagtc tcccgacacc

121 acctcccagg agcctcccga caccacctcc caggagcctc ccgacaccac ctcccaggag

181 cctcccgaca ccacctcccc ggagcctccc gacaagacct ccccggagcc cgccccccag

241 cagggctcca cacacacccc caggagccca ggctccacca ggactcgccg ccctgagatc

301 tcccaggctg ggcccacgca gggagaagtg atcccaacag gctgtgagtt ctg

1 ctctccccag cgtccaaacc tgcgggtgac cagctgcccg cggctctgtg gaccagcagt

61 gcggtgctgg gactgctgct cctggccttg cccacgtatc acctctggaa acgctgccgg

121 cacctggctg aggacgacac ccacccacca gcttctctga ggcttctgcc ccaggtgtcg

181 gcctgggctg ggttaagggg gaccggccag gtcgggatca gcccctcctg agtggccagc

241 ctttccccct gtgaaagcaa aatagcttgg accccttcaa gttgagaact ggtcagggca

301 aacctgcctc ccattctact caaagtcatc cctctgttca cagagatgga tgcatgttct

361 gattgcctct ttggagaagc tcatcagaaa ctcaaaagaa ggccactgtt tgtctcacct

421 acccatgacc tgaagcccct ccctgagtgg tccccacctt tctggacgga accacgtact

481 ttttacatac attgattcat gtctcacgtc tccctaaaaa tgcgtaagac caagctgtgc

541 cctgaccacc ctgggcccct gtcgtcagga cctcctgagg ctttggcaaa taaacctcct

601 aaaatgat EPI-109 101 1

1 gggactgagc atggatttcg gactggccct cctgctggcg gggcttctgg ggctcctcct 61 cggccagtcc ctccaggtga agcccctgca ggtggagccc ccggagccgg tggtggccgt 121 ggccttgggc gcctcgcgcc agctcacctg ccgcctggcc tgcgcggacc gcggggcctc 181 ggtgcagtgg cggggcctgg acaccagcct gggcgcggtg cagtcggaca cgggccgcag 241 cgtcctcacc gtgcgcaacg cctcgctgtc ggcggccggg acccgcgtgt gcgtgggctc 301 ctgcgggggc cgcaccttcc agcacaccgt gcagctcctt gtgtacgcct tcccggacca

361 gctgaccgtc tccccagcag ccctggtgcc tggtgacccg gaggtggcct gtacggccca 421 caaagtcacg cccgtggacc ccaacgcgct ctccttctcc ctgctcgtcg ggggccagga

481 actggagggg gcgcaagccc tgggcccgga ggtgcaggag gaggaggagg agccccaggg 541 ggacgaggac gtgctgttca gggtgacaga gcgctggcgg ctgccgcccc tggggacccc 601 tgtcccgccc gccctctact gccaggccac gatgaggctg cctggcttgg agctcagcca 661 ccgccaggcc atccccgtcc tgcacagccc gacctccccg gagcctcccg acaccacctc 721 cccggagtct cccgacacca cctccccgga gtctcccgac accacctccc cggagcctcc 781 cgacaccacc tccccggagc ctcccgacaa gacctccccg gagcccgccc cccagcaggg 841 ctccacacac acccccagga gcccaggctc caccaggact cgccgccctg agatctccca 901 ggctgggccc acgcagggag aagtgatccc aacaggctcg tccaaacctg cgggtgacca 961 gctgcccgcg gctctgtgga ccagcagtgc ggtgctggga ctgctgctcc tggccttgcc

1021 cacgtatcac ctctggaaac gctgccggca cctggctgag gacgacaccc acccaccagc

1081 ttctctgagg cttctgcccc aggtgtcggc ctgggctggg ttaaggggga ccggccaggt

1141 cgggatcagc ccctcctgag tggccagcct ttccccctgt gaaagcaaaa tagcttggac

1201 cccttcaagt tgagaactgg tcagggcaaa cctgcctccc attctactca aagtcatccc

1261 tctgttcaca gagatggatg catgttctga ttgcctcttt ggagaagctc atcagaaact

1321 caaaagaagg ccactgtttg tctcacctac ccatgacctg aagcccctcc ctgagtggtc

1381 cccacctttc tggacggaac cacgtacttt ttacatacat tgattcatgt ctcacgtctc

1441 cctaaaaatg cgtaagacca agctgtgccc tgaccaccct gggcccctgt cgtcaggacc

1501 tcctgaggct ttggcaaata aacctcctaa aatgataaaa aaaaaa

(2) INFORMATION FOR SEQ ID NO: 2732: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2732

1 ggaattccgg gcccggtctt tcctcccgcc gccgccggcc tggtcccggg gactggcctc

61 cacgtccgac tcgtccgagc tgaagcccag cagcactttg ctgccagccg cgggggcggc

121 ggaggcgccc ccgggccctc ccaggaggct ctctgggcca gaggccgaga ttcggcacag

181 gcccccagga gtccgtaagt aggagaggtc gcccgagacc ggccggaccc ccatccccgc

241 ggccgccgcc gccgctggtc ccgcggctgc gaccgtggcg gctgccgctg gaaaatgtct

301 caggagaggc ccacgttcta ccggcaggag ctgaacaaga caatctggga ggtgcccgag

361 cgttaccaga acctgtctcc agtgggctct ggcgcctatg gctctgtgtg tgctgctttt

421 gacacaaaaa cggggttacg tgtggcagtg aagaagctct ccagaccatt tcagtccatc

481 attcatgcga aaagaaccta cagagaactg cggttactta aacatatgaa acatgaaaat

541 gtgattggtc tgttggacgt ttttacacct gcaaggtctc tggaggaatt caatgatgtg

601 tatctggtga cccatctcat gggggcagat ctgaacaaca ttgtgaaatg tcagaagctt

661 acagatgacc atgttcagtt ccttatctac caaattctcc gaggtctaaa gtatatacat

721 tcagctgaca taattcacag ggacctaaaa cctagtaatc tagctgtgaa tgaagactgt

781 gagctgaaga ttctggattt tggactggct cggcacacag atgatgaaat gacaggctac

841 gtggccacta ggtggtacag ggctcctgag atcatgctga actggatgca ttacaaccag

901 acagttgata tttggtcagt gggatgcata atggccgagc tgttgactgg aagaacattg

961 tttcctggta cagaccatat tgatcagttg aagctcattt taagactcgt tggaacccca

1021 ggggctgagc ttttgaagaa aatctcctca gagtctgcaa gaaactatat tcagtctttg

1081 actcagatgc cgaagatgaa ctttgcgaat gtatttattg gtgccaatcc cctggctgtc

1141 gacttgctgg agaagatgct tgtattggac tcagataaga gaattacagc ggcccaagcc

1201 cttgcacatg cctactttgc tcagtaccac gatcctgatg atgaaccagt ggccgatcct

1261 tatgatcagt cctttgaaag cagggacctc cttatagatg agtggaaaag cctgacctat

1321 gatgaagtca tcagctttgt gccaccaccc cttgaccaag aagagatgga gtcctgagca

1381 cctggtttct gttctgttga tcccacttca ctgtgagggg aaggcctttt cacgggaact

1441 ctccaaatat tattcaagtg cctcttgttg cagagatttc ctccatggtg gaagggggtg

1501 tgcgtgcgtg tgcgtgcgtg ttagtgtgtg tgcatgtgt

(2) INFORMATION FOR SEQ ID NO:2733: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2733 1 aattaaccct cactaaaggg agtcgactcg atccccccgc ctcagcccct tttttctttt EPI-109 1012

61 ttttttcatt ttcagttcag gagagtttta gcttaattat aggctacaga accagctttg

121 ggcttcatct atcctttcta atatttactg tttcctattt ctctaatcct agctctttat

181 ttcttccctt tactttcact gggcttattt tgctatagtg gaatgcagag ggatgagtat

241 tccaggaagg cacaaaaact gtgccaagtc ttggagctag ggatgagtgg gaaagggaca

301 tgttcaacca ttttaggcca ttccctcccc acctcccagc tcccagatat gtgcccctcg

361 caggaggagc ccaggaatgg gccaaacacc tcacttcttt gctctgaggg ccaccccagc

421 cctcccatca acagctctag aaacccaatg gtccttcctg gaaacacggg gcctgcatca

481 atcagaggtg tttgaaccat gtccctctgg gcctgagggg cagaagggga cacaatatgt

541 aatgtaagga gcccctgtca tcagaaatct gacttaatct gttttcagat attagacttc

601 cacataaaag ttgacttgga aaaagacttc tgctgctaaa caaaagttga aactgccttg

661 gtgataaaat ataagcagac cagctttctc ttctagcttt ccctctcatt tcccataaga

721 ttttggtcaa gttatttaat ctctctgcat ccgtttcctc ttctatgaaa tgggcatgat

781 aataatggta tatacctcct caaggggggt ataacgtgaa cagagtcctt agcacagcac

841 tctgtctcta cgggagtgaa ttttcattgt ttttctcttt cctgttggag aaagtaagaa

901 gaaaacagcg cctttatggc ttcccatggt gaatggctgg ggcgcgtctg tgtccctgtc

961 tcctctctgg ctccttgtgg cctgaacagc cagaaggaag ccatgccatg ctgtttcagc

1021 cctcagcttc cctcttgcat ttcctagaaa agtctttggt gcccagctcc agctcagcag

1081 attcaggatc ccccttcatc atgacttggt caacgccctg ctcaggccaa ggtcctctga

1141 gagttccaag cttctccact ccctataaaa ggccggcgga acagccagag gagcagagag

1201 gcaaagaaac attgtgaaat ctccaactct taaccttcaa catgaaagtc tctgcagtgc

1261 ttctgtgcct gctgctcatg acagcagctt tcaaccccca gggacttgct cagccaggta

1321 agtcacctcc cttcgactct ccctctcttt ccctctgttt ctctattcaa ggaagaccta

1381 agcccgagtg ctcctccact ttttttttag attgagtctc attatgttgc ccaggctgaa

1441 gtgcaggggt gcgatcttgg ctcattgcaa ccttcacctc ccaggttcaa gcgattctct

1501 tgcctcagcc ttctgagtag ctgtgattac aggcaccgcc atcacgtgca gctaattttt

1561 gtatttttag tagagaaggg gtttcactat gttggccagg ctggtctcaa actcttgacc

1621 tcaagtgatc ctcccgtctc ggcctcccaa agtgctggga ttacaggcgt gagcaccagg

1681 cccagccaag tgccccactt ctaagcccac cagaatagta aggctcctca gaggttcact

1741 ttaacatcta attttaaaga tagaaagctg aagcccatgt tggaggcaga agggacccta

1801 gccatccacc tccaggttat tgcagagcaa gaatgaaacc taagcttctg actccagatt

1861 tagggccttt tctttgacct catctgatcg tcccaaactc tgcagatctg gaccacaccc

1921 agaccttccc actggccttg cccgtggcct cccctagatg gctgtgacat gtctccacca

1981 tgcagctgag cctttgagah cctgaggcac atgtcacagg tcccacctca cctcagggtc

2041 tagggtggga gtgctgggct tgggggtgag taagatctac ttcttcctct ttgctttgca

2101 tcccatacag atgctccctg ctgtattcaa gctgagaaaa gcctaacaca tcctcaaagt

2161 ctttttcttt gtaactattt ctagatgcac tcaacgtccc atctacttgc tgcttcacat

2221 ttagcagtaa gaagatctcc ttgcagaggc tgaagagcta tgtgatcacc accagcaggt

2281 gtccccagaa ggctgtcatg tgggtagaaa aatccctgct cgcctggctc ctccccactc

2341 ccacattccc caatccaaag ttctgcccca ggagacagac gtcagactga cttgagatct

2401 taggatgaga tctagccaga ctgtgtgatg caaaatcctc caattttggc tgcacaacag

2461 gtccaaagag gacctataat ttcccacacc ttgtttcctg gatgggcacc agcccacacc

2521 ctttagcaga tgccaggatc agtttcccag gggcagcaag agcagtggct gcctccagag

2581 accccttctg tccacacacc tcctacttcc tgtcctggag gggtgcccct tcacctgtag

2641 taggtggacc aggcaggtt^'t agaacccagt gtgtcatctc ctaggtaaac cctcaaaggg

2701 ttccatctaa ctgtgccaga tctccttcct ccacagcttc agaaccaaac tgggcaagga

2761 gatctgtgct gacccaaagg agaagtgggt ccagaattat atgaaacacc tgggccggaa

2821 agctcacacc ctgaagactt gaactctgct acccctactg aaatcaagct ggagtacgtg

2881 aaatgacttt tccattctcc tctggcctcc tcttctatgc tttggaatac ttctaccata

2941 attttcaaat aggatgcatt cggttttgtg attcaaaatg tactatgtgt taagtaatat

3001 tggctattat ttgacttgtt gctggtttgg agtttatttg agtattgctg atcttttcta

3061 aagcaaggcc ttgagcaagt aggttgctgt ctctaagccc ccttcccttc cactatgagc

3121 tgctggcagt gggtttgtat tcggttccca ggggttgagc

(2) INFORMATION FOR SEQ ID NO: 2734: (i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2734

1 ggcaaagaaa cattgtgaaa tctccaactc ttaaccttca acatgaaagt ctctgcagtg

61 cttctgtgcc tgctgctcat gacagcagct ttcaaccccc agggacttgc tcagccagat

121 gcactcaacg tcccatctac ttgctgcttc acatttagca gtaagaagat ctccttgcag

181 aggctgaaga gctatgtgat caccaccagc aggtgtcccc agaaggctgt catcttcaga

241 accaaactgg gcaaggagat ctgtgctgac ccaaaggaga agtgggtcca gaattatatg

301 aaacacctgg gccggaaagc tcacaccctg aagacttgaa ctctgctacc cctactgaaa

361 tcaagctgga gtacgtgaaa tgacttttcc attctcctct ggcctcctct tctatgcttt

421 ggaatacttc taccataatt ttcaaatagg atgcattcgg ttttgtgatt caaaatgtac

481 tatgtgttaa gtaatattgg ctattatttg acttgttgct ggtttggagt ttatttgagt EPI-109 1013

541 attgctgatc ttttctatag caaggccttg agcaagtagg ttgctgtctc taagccccct 601 tcccttccac tatgagctgc tggcagtggg tttgtattcg gttcccaggg gttgagagca 661 tgcctgtggg agtcatggac atgaagggat gccgcaatgt aggaaggaga gctctttgtg 721 aatgtgaggt gttgctaaat atgttattgt ggaaagatga atgcaatagt aggactgctg 781 acattttgca gaaaatacat tttatttaaa aatctcctaa aaaaaaaaaa aaaaaaaaaa 841 aagaaaaaaa aaaaa

(2) INFORMATION FOR SEQ ID NO:2735: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2735

1 acattgtgaa atctccaact cttaaccttc aacatgaaag tctctgcagt gcttctgtgc

61 ctgctgctca tgacagcagc tttcaacccc cagggacttg ctcagccaga tgcactcaac

121 gtcccatcta cttgctgctt cacatttagc agtaagaaga tctccttgca gaggctgaag

181 agctatgtga tcaccaccag caggtgtccc cagaaggctg tcatcttcag aaccaaactg

241 ggcaaggaga tctgtgctga cccaaaggag aagtgggtcc agaattatat gaaacacctg

301 ggccggaaag ctcacaccct gaagacttga actctgctac ccctactgaa atcaagctgg

361 agtacgtgaa atgacttttc cattctcctc tggcctcctc ttctatgctt tggaatactt

421 ctaccataat tttcaaatag gatgcattcg gttttgtgat tcaaaatgta ctatgtgtta

481 agtaatattg gctattattt gacttgttgc tggtttggag tttatttgag tattgctgat

541 cttttctaaa gcaaggcctt gagcaagtag gttgctgtct ctaagccccc ttcccttcca

601 ctatgagctg ctggcagtgg gttgtattcg gttcccaggg gttgagagca tgcctgtggg

661 agtcatggac atgaagggat gctgcaatgt aggaaggaga gctctttgtg aatgtgaggt

721 tgttgctaaa ttattgttta ttgtggaaag atgaatgcaa tagtaggact gctgacattt

781 tgcagaaaat acattttatt taaaatctcc taaaaaaaaa aaaaa

(2) INFORMATION FOR SEQ ID NO:2736: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2736

1 aaaaggccgg cggaacagcc agaggagcag agaggcaaag aaacattgtg aaatctccaa

61 ctcttaacct tcaacatgaa agtctctgca gtgcttctgt gcctgctgct catgacagca

121 gctttcaacc cccagggact tgctcagcca gatgcactca acgtcccatc tacttgctgc

181 ttcacattta gcagtaagaa gatctccttg cagaggctga agagctatgt gatcaccacc

241 agcaggtgtc cccagaaggc tgtcatcttc agaaccaaac tgggcaagga gatctgtgct

301 gacccaaagg agaagtgggt ccagaattat atgaaacacc tgggccggaa agctcacacc

361 ctgaagactt gaactctgct acccctactg aaatcaagct ggagtacgtg aaatgacttt

421 tccattctcc tctggcctcc tcttctatgc tttggaatac ttctaccata attttcaaat

481 aggatgcatt cggttttgtg attcaaaatg tactatgtgt taagtaatat tggctattat

541 ttgacttgtt gctggtttgg agtttatttg agtattgctg atcttttcta aagcaaggcc

601 ttgagcaagt aggttgctgt ctctaagccc ccttcccttc cactatgagc tgctggcagt

661 gggtttgtat tcggttccca ggggttgaga gcatgcctgt gggagtcatg gacatgaagg

721 gatgctgcaa tgtaggaagg agagctcttt gtgaatgtga ggtgttgcta aatatgttat

781 tgtggaaaga tgaatgcaat agtaggactg ctgacatttt gcagaaaata cattttattt

841 aaaatctcca aaaaaaaaaa

(2) INFORMATION FOR SEQ ID NO: 2737: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2737

1 aattaaccct cactaaaggg agtcgactcg atccccccgc ctcagcccct tttttctttt

61 ttttttcatt ttcagttcag gagagtttta gcttaattat aggctacaga accagctttg

121 ggcttcatct atcctttcta atatttactg tttcctattt ctctaatcct agctctttat

181 ttcttccctt tactttcact gggcttattt tgctatagtg gaatgcagag ggatgagtat

241 tccaggaagg cacaaaaact gtgccaagtc ttggagctag ggatgagtgg gaaagggaca

301 tgttcaacca ttttaggcca ttccctcccc acctcccagc tcccagatat gtgcccctcg

361 caggaggagc ccaggaatgg gccaaacacc tcacttcttt gctctgaggg ccaccccagc

421 cctcccatca acagctctag aaacccaatg gtccttcctg gaaacacggg gcctgcatca

481 atcagaggtg tttgaaccat gtccctctgg gcctgagggg cagaagggga cacaatatgt

541 aatgtaagga gcccctgtca tcagaaatct gacttaatct gttttcagat attagacttc EPI-109 1014

601 cacataaaag ttgacttgga aaaagacttc tgctgctaaa caaaagttga aactgccttg

661 gtgataaaat ataagcagac cagctttctc ttctagcttt ccctctcatt tcccataaga

721 ttttggtcaa gttatttaat ctctctgcat ccgtttcctc ttctatgaaa tgggcatgat

781 aataatggta tatacctcct caaggggggt ataacgtgaa cagagtcctt agcacagcac

841 tctgtctcta cgggagtgaa ttttcattgt ttttctcttt cctgttggag aaagtaagaa

901 gaaaacagcg cctttatggc ttcccatggt gaatggctgg ggcgcgtctg tgtccctgtc

961 tcctctctgg ctccttgtgg cctgaacagc cagaaggaag ccatgccatg ctgtttcagc

1021 cctcagcttc cctcttgcat ttcctagaaa agtctttggt gcccagctcc agctcagcag

1081 attcaggatc ccccttcatc atgacttggt caacgccctg ctcaggccaa ggtcctctga

1141 gagttccaag cttctccact ccctataaaa ggccggcgga acagccagag gagcagagag

1201 gcaaagaaac attgtgaaat ctccaactct taaccttcaa catgaaagtc tctgcagtgc

1261 ttctgtgcct gctgctcatg acagcagctt tcaaccccca gggacttgct cagccaggta

1321 agtcacctcc cttcgactct ccctctcttt ccctctgttt ctctattcaa ggaagaccta

1381 agcccgagtg ctcctccact ttttttttag attgagtctc attatgttgc ccaggctgaa

1441 gtgcaggggt gcgatcttgg ctcattgcaa ccttcacctc ccaggttcaa gcgattctct

1501 tgcctcagcc ttctgagtag ctgtgattac aggcaccgcc atcacgtgca gctaattttt

1561 gtatttttag tagagaaggg gtttcactat gttggccagg ctggtctcaa actcttgacc

1621 tcaagtgatc ctcccgtctc ggcctcccaa agtgctggga ttacaggcgt gagcaccagg

1681 cccagccaag tgccccactt ctaagcccac cagaatagta aggctcctca gaggttcact

1741 ttaacatcta attttaaaga tagaaagctg aagcccatgt tggaggcaga agggacccta

1801 gccatccacc tccaggttat tgcagagcaa gaatgaaacc taagcttctg actccagatt

1861 tagggccttt tctttgacct catctgatcg tcccaaactc tgcagatctg gaccacaccc

1921 agaccttccc actggccttg cccgtggcct cccctagatg gctgtgacat gtctccacca

1981 tgcagctgag cctttgagah cctgaggcac atgtcacagg tcccacctca cctcagggtc

2041 tagggtggga gtgctgggct tgggggtgag taagatctac ttcttcctct ttgctttgca

2101 tcccatacag atgctccctg ctgtattcaa gctgagaaaa gcctaacaca tcctcaaagt

2161 ctttttcttt gtaactattt ctagatgcac tcaacgtccc atctacttgc tgcttcacat

2221 ttagcagtaa gaagatctcc ttgcagaggc tgaagagcta tgtgatcacc accagcaggt

2281 gtccccagaa ggctgtcatg tgggtagaaa aatccctgct cgcctggctc ctccccactc

2341 ccacattccc caatccaaag ttctgcccca ggagacagac gtcagactga cttgagatct

2401 taggatgaga tctagccaga ctgtgtgatg caaaatcctc caattttggc tgcacaacag

2461 gtccaaagag gacctataat ttcccacacc ttgtttcctg gatgggcacc agcccacacc

2521 ctttagcaga tgccaggatc agtttcccag gggcagcaag agcagtggct gcctccagag

2581 accccttctg tccacacacc tcctacttcc tgtcctggag gggtgcccct tcacctgtag

2641 taggtggacc aggcaggttt agaacccagt gtgtcatctc ctaggtaaac cctcaaaggg

2701 ttccatctaa ctgtgccaga tctccttcct ccacagcttc agaaccaaac tgggcaagga

2761 gatctgtgct gacccaaagg agaagtgggt ccagaattat atgaaacacc tgggccggaa

2821 agctcacacc ctgaagactt gaactctgct acccctactg aaatcaagct ggagtacgtg

2881 aaatgacttt tccattctcc tctggcctcc tcttctatgc tttggaatac ttctaccata

2941 attttcaaat aggatgcatt cggttttgtg attcaaaatg tactatgtgt taagtaatat

3001 tggctattat ttgacttgtt gctggtttgg agtttatttg agtattgctg atcttttcta

3061 aagcaaggcc ttgagcaagt aggttgctgt ctctaagccc ccttcccttc cactatgagc

3121 tgctggcagt gggtttgtat tcggttccca ggggttgagc

1 ggcaaagaaa cattgtgaaa tctccaactc ttaaccttca acatgaaagt ctctgcagtg

61 cttctgtgcc tgctgctcat gacagcagct ttcaaccccc agggacttgc tcagccagat

121 gcactcaacg tcccatctac ttgctgcttc acatttagca gtaagaagat ctccttgcag

181 aggctgaaga gctatgtgat caccaccagc aggtgtcccc agaaggctgt catcttcaga

241 accaaactgg gcaaggagat ctgtgctgac ccaaaggaga agtgggtcca gaattatatg

301 aaacacctgg gccggaaagc tcacaccctg aagacttgaa ctctgctacc cctactgaaa

361 tcaagctgga gtacgtgaaa tgacttttcc attctcctct ggcctcctct tctatgcttt

421 ggaatacttc taccataatt ttcaaatagg atgcattcgg ttttgtgatt caaaatgtac

481 tatgtgttaa gtaatattgg ctattatttg acttgttgct ggtttggagt ttatttgagt

541 attgctgatc ttttctatag caaggccttg agcaagtagg ttgctgtctc taagccccct

601 tcccttccac tatgagctgc tggcagtggg tttgtattcg gttcccaggg gttgagagca

661 tgcctgtggg agtcatggac atgaagggat gccgcaatgt aggaaggaga gctctttgtg

721 aatgtgaggt gttgctaaat atgttattgt ggaaagatga atgcaatagt aggactgctg

781 acattttgca gaaaatacat tttatttaaa aatctcctaa aaaaaaaaaa aaaaaaaaaa

841 aagaaaaaaa aaaaa

1 acattgtgaa atctccaact cttaaccttc aacatgaaag tctctgcagt gcttctgtgc

61 ctgctgctca tgacagcagc tttcaacccc cagggacttg ctcagccaga tgcactcaac

121 gtcccatcta cttgctgctt cacatttagc agtaagaaga tctccttgca gaggctgaag

181 agctatgtga tcaccaccag caggtgtccc cagaaggctg tcatcttcag aaccaaactg

241 ggcaaggaga tctgtgctga cccaaaggag aagtgggtcc agaattatat gaaacacctg

301 ggccggaaag ctcacaccct gaagacttga actctgctac ccctactgaa atcaagctgg

361 agtacgtgaa atgacttttc cattctcctc tggcctcctc ttctatgctt tggaatactt

421 ctaccataat tttcaaatag gatgcattcg gttttgtgat tcaaaatgta ctatgtgtta

481 agtaatattg gctattattt gacttgttgc tggtttggag tttatttgag tattgctgat

541 cttttctaaa gcaaggcctt gagcaagtag gttgctgtct ctaagccccc ttcccttcca EPI-109 1015

601 ctatgagctg ctggcagtgg gttgtattcg gttcccaggg gttgagagca tgcctgtggg 661 agtcatggac atgaagggat gctgcaatgt aggaaggaga gctctttgtg aatgtgaggt 721 tgttgctaaa ttattgttta ttgtggaaag atgaatgcaa tagtaggact gctgacattt 781 tgcagaaaat acattttatt taaaatctcc taaaaaaaaa aaaaa

1 aaaaggccgg cggaacagcc agaggagcag agaggcaaag aaacattgtg aaatctccaa 61 ctcttaacct tcaacatgaa agtctctgca gtgcttctgt gcctgctgct catgacagca 121 gctttcaacc cccagggact tgctcagcca gatgcactca acgtcccatc tacttgctgc 181 ttcacattta gcagtaagaa gatctccttg cagaggctga agagctatgt gatcaccacc 241 agcaggtgtc cccagaaggc tgtcatcttc agaaccaaac tgggcaagga gatctgtgct 301 gacccaaagg agaagtgggt ccagaattat atgaaacacc tgggccggaa agctcacacc 361 ctgaagactt gaactctgct acccctactg aaatcaagct ggagtacgtg aaatgacttt 421 tccattctcc tctggcctcc tcttctatgc tttggaatac ttctaccata attttcaaat 481 aggatgcatt cggttttgtg attcaaaatg tactatgtgt taagtaatat tggctattat 541 ttgacttgtt gctggtttgg agtttatttg agtattgctg atcttttcta aagcaaggcc 601 ttgagcaagt aggttgctgt ctctaagccc ccttcccttc cactatgagc tgctggcagt 661 gggtttgtat tcggttccca ggggttgaga gcatgcctgt gggagtcatg gacatgaagg 721 gatgctgcaa tgtaggaagg agagctcttt gtgaatgtga ggtgttgcta aatatgttat 781 tgtggaaaga tgaatgcaat agtaggactg ctgacatttt gcagaaaata cattttattt 841 aaaatctcca aaaaaaaaaa

(2) INFORMATION FOR SEQ ID NO: 2738: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2738

1 cgcccgggca ggtcctctgc ctagcactgc tcccccaagg ctcccagaaa tctcaggtca

61 gaggcacgga cagcctctgg agctctcgtc tggtgggacc atgaactgcc agcagctgtg

121 gctgggcttc ctactcccca tgacagtctc aggccgggtc ctggggcttg cagaggtggc

181 gcccgtggac tacctgtcac aatatgggta cctacagaag cctctagaag gatctaataa

241 cttcaagcca gaagatatca ccgaggctct gagagctttt caggaagcat ctgaacttcc

301 agtctcaggt cagctggatg atgccacaag ggcccgcatg aggcagcctc gttgtggcct

361 agaggatccc ttcaaccaga agacccttaa atacctgttg ctgggccgct ggagaaagaa

421 gcacctgact ttccgcatct tgaacctgcc ctccaccctt ccaccccaca cagcccgggc

481 agccctgcgt caagccttcc aggactggag caatgtggct cccttgacct tccaagaggt

541 gcaggctggt gcggctgaca tccgcctctc cttccatggc cgccaaagct cgtactgttc

601 caatactttt gatgggcctg ggagagtcct ggcccatgcc gacatcccag agctgggcag

661 tgtgcacttc gacgaagacg agttctggac tgaggggacc taccgtgggg tgaacctgcg

721 catcattgca gcccatgaag tgggccatgc tctggggctt gggcactccc gatattccca

781 ggccctcatg gccccagtct acgagggcta ccggccccac tttaagctgc acccagatga

841 tgtggcaggg atccaggctc tctatggcaa gaagagtcca gtgataaggg atgaggaaga

901 agaagagaca gagctgccca ctgtgccccc agtgcccaca gaacccagtc ccatgccaga

961 cccttgcagt agtgaactgg atgccatgat gctggggccc cgtgggaaga cctatgcttt

1021 caagggggac tatgtgtgga ctgtatcaga ttcaggaccg ggccccttgt tccgagtgtc

1081 tgccctttgg gaggggctcc ccggaaacct ggatgctgct gtctactcgc ctcgaacaca

1141 atggattcac ttctttaagg gagacaaggt gtggcgctac attaatttca agatgtctcc

1201 tggcttcccc aagaagctga ataggtcaga acctaacctg gatgcagctc tctattggcc

1261 tctcaaccaa aaggtgttcc tctttaaggg ctccgggtac tggcagtggg acgagctagc

1321 ccgaactgac ttcagcagct accccaaacc aatcaagggt ttgtttacgg gagtgccaaa

1381 ccagccctcg gctgctatga gttggcaaga tggccgagtc tacttcttca agggcaaagt

1441 ctactggcgc ctcaaccagc agcttcgagt agagaaaggc tatcccagaa atatttccca

1501 caactggatg cactgtcgtc cccggactat agacactacc ccatcaggtg ggaataccac

1561 tccctcaggt acgggcataa ccttggatac cactctctca gccacagaaa ccacgtttga

1621 atactgactg ctcacccaca gacacaatct tggacattaa cccctgaggc tccaccaccc

1681 accctttcat ttccccccca gaagcctaag gcctaatagc tgaatgaaat acctgtctgc

1741 tcagtagaac cttgcaggtg ctgtagcagg cgcaagaccg tagatctcag gcctctaaca

1801 cttccaactc cagccaccac tttcctgtgc attttcactc ctgagaagtg ctcccctaac

1861 tcagatcccc taacttagat ttggccccca actccatttc ctgtctgtct tagacagccc

1921 ttccaactgt gtcatctctt ctctggaggt caatggtgga gggagatgcc tgggtcctgt

1981 tcttcctaca taaaatgcaa gaaaacagca tggccagtaa actgagcaag ggccttggaa

2041 tccttgagaa tcacatttat gtgcttatga ttacgggcaa gctaattaac cttgttgaat

2101 ctcagattcc ccatttgcaa cattaggtta agaccagtac tgcaggattg ttgcactaaa

2161 tgaaatactg tatgtgaagt gcctggcaca gtgtctggta catttgtgtt taataaaagc

2221 taactccatg ttcataagaa aaaaaaaa

(2) INFORMATION FOR SEQ ID NO: 2739:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs EPI-109 1016

(B ) TYPE : nucleic acid

(C ) STRANDEDNESS : single

( D) TOPOLOGY : linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2739

1 ggagaccggc cgcatggacc cagggacagt ggccaccatg cgtaagcccc gctgctccct 61 gcctgacgtg ctgggggtgg cggggctggt caggcggcgt cgccggtacg ctctgagcgg 121 cagcgtgtgg aagaagcgaa ccctgacatg gagggtacgt tccttccccc agagctccca 181 gctgagccag gagaccgtgc gggtcctcat gagctatgcc ctgatggcct ggggcatgga 241 gtcaggcctc acatttcatg aggtggattc cccccagggc caggagcccg acatcctcat 301 cgactttgcc cgcgccttcc accaggacag ctaccccttc gacgggttgg ggggcaccct 361 agcccatgcc ttcttccctg gggagcaccc catctccggg gacactcact ttgacgatga 421 ggagacctgg acttttgggt caaaagcctc tcagcagctg gagcaggagc tggcaggcgg 481 ctcaccggtt gatgaggagc tgggcttcag ccggggctgg cgtgtgaatc ctctgggtcc 541 tggcagtcct gagcgcctga gctgaataca gagggaagag gctgggagca aggccgggtg 601 ctggggccgg caggctgtgt tctgaga

(2) INFORMATION FOR SEQ ID NO: 2740: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2740

1 atgatcttac tcacattcag cactggaaga cggttggatt tcgtgcatca ttcgggggtg

61 tttttcttgc aaaccttgct ttggatttta tgtgctacag tctgcggaac ggagcagtat

121 ttcaatgtgg aggtttggtt acaaaagtac ggctaccttc caccgactga ccccagaatg

181 tcagtgctgc gctctgcaga gaccatgcag tctgccctag ctgccatgca gcagttctat

241 ggcattaaca tgacaggaaa agtggacaga aacacaattg actggatgaa gaagccccga

301 tgcggtgtac ctgaccagac aagaggtagc tccaaatttc atattcgtcg aaagcgatat

361 gcattgacag gacagaaatg gcagcacaag cacatcactt acagtataaa gaacgtaact

421 ccaaaagtag gagaccctga gactcgtaaa gctattcgcc gtgcctttga tgtgtggcag

481 aatgtaactc ctctgacatt tgaagaagtt ccctacagtg aattagaaaa tggcaaacgt

541 gatgtggata taaccattat ttttgcatct ggtttccatg gggacagctc tccctttgat

601 ggagagggag gatttttggc acatgcctac ttccctggac caggaattgg aggagatacc

661 cattttgact cagatgagcc atggacacta ggaaatccta atcatgatgg aaatgactta

721 tttcttgtag cagtccatga actgggacat gctctgggat tggagcattc caatgacccc

781 actgccatca tggctccatt ttaccagtac atggaaacag acaacttcaa actacctaat

841 gatgatttac agggcatcca gaagatatat ggtccacctg acaagattcc tccacctaca

901 agacctctac cgacagtgcc cccacaccgc tctattcctc cggctgaccc aaggaaaaat

961 gacaggccaa aacctcctcg gcctccaacc ggcagaccct cctatcccgg agccaaaccc

1021 aacatctgtg atgggaactt taacactcta gctattcttc gtcgtgagat gtttgttttc

1081 aaggaccagt ggttttggcg agtgagaaac aacagggtga tggatggata cccaatgcaa

1141 attacttact tctggcgggg cttgcctcct agtatcgatg cagtttatga aaatagcgac

1201 gggaattttg tgttctttaa agtgaaggga gacactctat ctgtaatcca agatggttgg

1261 ctctacaaat accattggaa atggattcta gaacaaaggc agtcagtgcc tgtgctctca

1321 agacaaactg aaaagcacaa gacctatgaa gaattatctt ccatcacata ctaacaaaga

1381 acaatcagga attgaaaatt taaaataaaa ggccatttac aattgcattc gaaaacacca

1441 aataccgagg gatcaatctg caaaaaatgt gcatgacctc tacattgaaa acaacaaaac

1501 actactaaat gtttgtcttt aaaggcagct gg

(2) INFORMATION FOR SEQ ID NO:2741: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2741

1 tagaagttta caatgaagtt tcttctaata ctgctcctgc aggccactgc ttctggagct

61 cttcccctga acagctctac aagcctggaa aaaaataatg tgctatttgg tgagagatac

121 ttagaaaaat tttatggcct tgagataaac aaacttccag tgacaaaaat gaaatatagt

181 ggaaacttaa tgaaggaaaa aatccaagaa atgcagcact tcttgggtct gaaagtgacc

241 gggcaactgg acacatctac cctggagatg atgcacgcac ctcgatgtgg agtccccgat

301 ctccatcatt tcagggaaat gccagggggg cccgtatgga ggaaacatta tatcacctac

361 agaatcaata attacacacc tgacatgaac cgtgaggatg ttgactacgc aatccggaaa

421 gctttccaag tatggagtaa tgttaccccc ttgaaattca gcaagattaa cacaggcatg

481 gctgacattt tggtggtttt tgcccgtgga gctcatggag acttccatgc ttttgatggc

541 aaaggtggaa tcctagccca tgcttttgga cctggatctg gcattggagg ggatgcacat

601 ttcgatgagg acgaattctg gactacacat tcaggaggca caaacttgtt cctcactgct

661 gttcacgaga ttggccattc cttaggtctt ggccattcta gtgatccaaa ggctgtaatg

721 ttccccacct acaaatatgt cgacatcaac acatttcgcc tctctgctga tgacatacgt EPI-109 1017

781 ggcattcagt ccctgtatgg agacccaaaa gagaaccaac gcttgccaaa tcctgacaat 841 tcagaaccag ctctctgtga ccccaatttg agttttgatg ctgtcactac cgtgggaaat 901 aagatctttt tcttcaaaga caggttcttc tggctgaagg tttctgagag accaaagacc 961 agtgttaatt taatttcttc cttatggcca accttgccat ctggcattga agctgcttat 1021 gaaattgaag ccagaaatca agtttttctt tttaaagatg acaaatactg gttaattagc 1081 aatttaagac cagagccaaa ttatcccaag agcatacatt cttttggttt tcctaacttt 1141 gtgaaaaaaa ttgatgcagc tgtttttaac ccacgttttt ataggaccta cttctttgta 1201 gataaccagt attggaggta tgatgaaagg agacagatga tggaccctgg ttatcccaaa 1261 ctgattacca agaacttcca aggaatcggg cctaaaattg atgcagtctt ctattctaaa 1321 aacaaatact actatttctt ccaaggatct aaccaatttg aatatgactt cctactccaa 1381 cgtatcacca aaacactgaa aagcaatagc tggtttggtt gttagaaatg gtgtaattaa 1441 tggtttttgt tagttcactt cagcttaata agtatttatt gcatatttgc tatgtcctca 1501 gtgtaccact acttagagat atgtatcata aaaataaaat ctgtaaacca taggtaatga 1561 ttatataaaa tacataatat ttttcaattt tgaaaactct aattgtccat tcttgcttga 1621 ctctactatt aagtttgaaa atagttacct tcaaagcaag ataattctat ttgaagcatg 1681 ctctgtaagt tgcttcctaa catccttgga ctgagaaatt atacttactt ctggcataac 1741 taaaattaag tatatatatt ttggctcaaa taaaattg

(2) INFORMATION FOR SEQ ID NO:2742: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xι)SEQUENCE DESCRIPTION: SEQ ID NO:2742

L aaagaaggta agggcagtga gaatgatgca tcttgcattc cttgtgctgt tgtgtctgcc

61 agtctgctct gcctatcctc tgagtggggc agcaaaagag gaggactcca acaaggatct

121 tgcccagcaa tacctagaaa agtactacaa cctcgaaaag gatgtgaaac agtttagaag

181 aaaggacagt aatctcattg ttaaaaaaat ccaaggaatg cagaagttcc ttgggttgga

241 ggtgacaggg aagctagaca ctgacactct ggaggtgatg cgcaagccca ggtgtggagt

301 tcctgacgtt ggtcacttca gctcctttcc tggcatgccg aagtggagga aaacccacct

361 tacatacagg attgtgaatt atacaccaga tttgccaaga gatgctgttg attctgccat

421 tgagaaagct ctgaaagtct gggaagaggt gactccactc acattctcca ggctgtatga

481 aggagaggct gatataatga tctctttcgc agttaaagaa catggagact tttactcttt

541 tgatggccca ggacacagtt tggctcatgc ctacccacct ggacctgggc tttatggaga

601 tattcacttt gatgatgatg aaaaatggac agaagatgca tcaggcacca atttattcct

661 cgttgctgct catgaacttg gccactccct ggggctcttt cactcagcca acactgaagc

721 tttgatgtac ccactctaca actcattcac agagctcgcc cagttccgcc tttcgcaaga

781 tgatgtgaat ggcattcagt ctctctacgg acctccccct gcctctactg aggaacccct

841 ggtgcccaca aaatctgttc cttcgggatc tgagatgcca gccaagtgtg atcctgcttt

901 gtccttcgat gccatcagca ctctgagggg agaatatctg ttctttaaag acagatattt

961 ttggcgaaga tcccactgga accctgaacc tgaatttcat ttgatttctg cattttggcc

1021 ctctcttcca tcatatttgg atgctgcata tgaagttaac agcagggaca ccgtttttat

1081 ttttaaagga aatgagttct gggccatcag aggaaatgag gtacaagcag gttatccaag

1141 aggcatccat accctgggtt ttcctccaac cataaggaaa attgatgcag ctgtttctga

1201 caaggaaaag aagaaaacat acttctttgc agcggacaaa tactggagat ttgatgaaaa

1261 tagccagtcc atggagcaag gcttccctag actaatagct gatgactttc caggagttga

1321 gcctaaggtt gatgctgtat tacaggcatt tggatttttc tacttcttca gtggatcatc

1381 acagtttgag tttgacccca atgccaggat ggtgacacac atattaaaga gtaacagctg

1441 gttacattgc taggcgagat agggggaaga cagatatggg tgtttttaat aaatctaata

1501 attattcatc taatgtatta tgagccaaaa tggttaattt ttcctgcatg ttctgtgact

1561 gaagaagatg agccttgcag atatctgcat gtgtcatgaa gaatgtttct ggaattcttc

1621 acttgctttt gaattgcact gaacagaatt aagaaatact catgtgcaat aggtgagaga

1681 atgtattttc atagatgtgt tattacttcc tcaataaaaa gttttatttt gggcctgttc

1741 ctt

2) INFORMATION FOR SEQ ID NO: 2743: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2743

1 ctgaggtggg taagagtaca atggctaaat cttaacacac tcttacgtgt acaccctacc 61 gtacaccatc cagactcgtc cccatacaat caggagtgat cagtacgtaa atgcttatgg 121 tgtgatttga aggggtgtta gagtagatca tctctcacac cgcagcagca ctgcttccaa 181 ttcatccttt ggaattttat tccctgactg ttaaaagttt ttagtgctta aatattctct 241 attgaggtaa gagacagatt ctgtgcaatg ggacaattag gtcaagaggg aaagaagctg 301 aggtgatagg cagatagatt ccagaggcaa acttttccca tctgctaaag ttgaaaagag EPI-109 1018

361 taacccacat cctaccaacg ctagacaatc taggatgtag ggaaagtttg tctctggaat

421 ctatccaggt acccagttgg gactgagctt cagcttagat gtctgaagat gttaagttat

481 agaatcaggt ttaagtctga agatgttaag ttatagaatc aggatctgag ccggtacaac

541 acgtggataa acaatgaagt cgatgttaca aatttttttt tgctacttgt aaaatctctg

601 tatcacattt ctctagggag ctggattccg tttaggagca ctcatttact ccaggaaaag

661 gattttattt aatctttcaa catttacttt aaaaactttt tttatctata atgaatataa

721 ggaagtatta taatgaaaac caagttatca ggctttaaga aaatatattt taagttctcc

781 ttctctttta gttgcttgat atttctttta caagggctta ttttgtagat aggtggacgt

841 agaggcttat ttatcatttt gaaggtacat actctgaatt gcttgagtga tggactagat

901 gctaattgat ccattgtcgt ctgaataaag tcatgctttt gtttgcatgt ttttagagat

961 agtcaaggga tgatatcaac tatgagtcac tcataggatt catattcaca gaacccggac

1021 taagggctat ataaagagga acagttcagg aacttaggct agaaaggaca cagtaaactg

1081 aattgatccg tttagaagtt tacaatgaag tttcttctaa tactgctcct gcaggccact

1141 gcttctggag ctcttcccct gaacagctct acaagcctgg aaaaaaataa tgtgctattg

1201 ggtgagaga

(2) INFORMATION FOR SEQ ID NO: 2744: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2744

1 cgcccgggca ggtcctctgc ctagcactgc tcccccaagg ctcccagaaa tctcaggtca

61 gaggcacgga cagcctctgg agctctcgtc tggtgggacc atgaactgcc agcagctgtg

121 gctgggcttc ctactcccca tgacagtctc aggccgggtc ctggggcttg cagaggtggc

181 gcccgtggac tacctgtcac aatatgggta cctacagaag cctctagaag gatctaataa

241 cttcaagcca gaagatatca ccgaggctct gagagctttt caggaagcat ctgaacttcc

301 agtctcaggt cagctggatg atgccacaag ggcccgcatg aggcagcctc gttgtggcct

361 agaggatccc ttcaaccaga agacccttaa atacctgttg ctgggccgct ggagaaagaa

421 gcacctgact ttccgcatct tgaacctgcc ctccaccctt ccaccccaca cagcccgggc

481 agccctgcgt caagccttcc aggactggag caatgtggct cccttgacct tccaagaggt

541 gcaggctggt gcggctgaca tccgcctctc cttccatggc cgccaaagct cgtactgttc

601 caatactttt gatgggcctg ggagagtcct ggcccatgcc gacatcccag agctgggcag

661 tgtgcacttc gacgaagacg agttctggac tgaggggacc taccgtgggg tgaacctgcg

721 catcattgca gcccatgaag tgggccatgc tctggggctt gggcactccc gatattccca

781 ggccctcatg gccccagtct acgagggcta ccggccccac tttaagctgc acccagatga

841 tgtggcaggg atccaggctc tctatggcaa gaagagtcca gtgataaggg atgaggaaga

901 agaagagaca gagctgccca ctgtgccccc agtgcccaca gaacccagtc ccatgccaga

961 cccttgcagt agtgaactgg atgccatgat gctggggccc cgtgggaaga cctatgcttt

1021 caagggggac tatgtgtgga ctgtatcaga ttcaggaccg ggccccttgt tccgagtgtc

1081 tgccctttgg gaggggctcc ccggaaacct ggatgctgct gtctactcgc ctcgaacaca

1141 atggattcac ttctttaagg gagacaaggt gtggcgctac attaatttca agatgtctcc

1201 tggcttcccc aagaagctga ataggtcaga acctaacctg gatgcagctc tctattggcc

1261 tctcaaccaa aaggtgttcc tctttaaggg ctccgggtac tggcagtggg acgagctagc

1321 ccgaactgac ttcagcagct accccaaacc aatcaagggt ttgtttacgg gagtgccaaa

1381 ccagccctcg gctgctatga gttggcaaga tggccgagtc tacttcttca agggcaaagt

1441 ctactggcgc ctcaaccagc agcttcgagt agagaaaggc tatcccagaa atatttccca

1501 caactggatg cactgtcgtc cccggactat agacactacc ccatcaggtg ggaataccac

1561 tccctcaggt acgggcataa ccttggatac cactctctca gccacagaaa ccacgtttga

1621 atactgactg ctcacccaca gacacaatct tggacattaa cccctgaggc tccaccaccc

1681 accctttcat ttccccccca gaagcctaag gcctaatagc tgaatgaaat acctgtctgc

1741 tcagtagaac cttgcaggtg ctgtagcagg cgcaagaccg tagatctcag gcctctaaca

1801 cttccaactc cagccaccac tttcctgtgc attttcactc ctgagaagtg ctcccctaac

1861 tcagatcccc taacttagat ttggccccca actccatttc ctgtctgtct tagacagccc

1921 ttccaactgt gtcatctctt ctctggaggt caatggtgga gggagatgcc tgggtcctgt

1981 tcttcctaca taaaatgcaa gaaaacagca tggccagtaa actgagcaag ggccttggaa

2041 tccttgagaa tcacatttat gtgcttatga ttacgggcaa gctaattaac cttgttgaat

2101 ctcagattcc ccatttgcaa cattaggtta agaccagtac tgcaggattg ttgcactaaa

2161 tgaaatactg tatgtgaagt gcctggcaca gtgtctggta catttgtgtt taataaaagc

2221 taactccatg ttcataagaa aaaaaaaa

1 ggagaccggc cgcatggacc cagggacagt ggccaccatg cgtaagcccc gctgctccct

61 gcctgacgtg ctgggggtgg cggggctggt caggcggcgt cgccggtacg ctctgagcgg

121 cagcgtgtgg aagaagcgaa ccctgacatg gagggtacgt tccttccccc agagctccca

181 gctgagccag gagaccgtgc gggtcctcat gagctatgcc ctgatggcct ggggcatgga

241 gtcaggcctc acatttcatg aggtggattc cccccagggc caggagcccg acatcctcat

301 cgactttgcc cgcgccttcc accaggacag ctaccccttc gacgggttgg ggggcaccct

361 agcccatgcc ttcttccctg gggagcaccc catctccggg gacactcact ttgacgatga

421 ggagacctgg acttttgggt caaaagcctc tcagcagctg gagcaggagc tggcaggcgg EPI-109 1019

481 ctcaccggtt gatgaggagc tgggcttcag ccggggctgg cgtgtgaatc ctctgggtcc

541 tggcagtcct gagcgcctga gctgaataca gagggaagag gctgggagca aggccgggtg

601 ctggggccgg caggctgtgt tctgaga

1 atgatcttac tcacattcag cactggaaga cggttggatt tcgtgcatca ttcgggggtg

61 tttttcttgc aaaccttgct ttggatttta tgtgctacag tctgcggaac ggagcagtat

121 ttcaatgtgg aggtttggtt acaaaagtac ggctaccttc caccgactga ccccagaatg

181 tcagtgctgc gctctgcaga gaccatgcag tctgccctag ctgccatgca gcagttctat

241 ggcattaaca tgacaggaaa agtggacaga aacacaattg actggatgaa gaagccccga

301 tgcggtgtac ctgaccagac aagaggtagc tccaaatttc atattcgtcg aaagcgatat

361 gcattgacag gacagaaatg gcagcacaag cacatcactt acagtataaa gaacgtaact

421 ccaaaagtag gagaccctga gactcgtaaa gctattcgcc gtgcctttga tgtgtggcag

481 aatgtaactc ctctgacatt tgaagaagtt ccctacagtg aattagaaaa tggcaaacgt

541 gatgtggata taaccattat ttttgcatct ggtttccatg gggacagctc tccctttgat

601 ggagagggag gatttttggc acatgcctac ttccctggac caggaattgg aggagatacc

661 cattttgact cagatgagcc atggacacta ggaaatccta atcatgatgg aaatgactta

721 tttcttgtag cagtccatga actgggacat gctctgggat tggagcattc caatgacccc

781 actgccatca tggctccatt ttaccagtac atggaaacag acaacttcaa actacctaat

841 gatgatttac agggcatcca gaagatatat ggtccacctg acaagattcc tccacctaca

901 agacctctac cgacagtgc^'c cccacaccgc tctattcctc cggctgaccc aaggaaaaat

961 gacaggccaa aacctcctcg gcctccaacc ggcagaccct cctatcccgg agccaaaccc

1021 aacatctgtg atgggaactt taacactcta gctattcttc gtcgtgagat gtttgttttc

1081 aaggaccagt ggttttggcg agtgagaaac aacagggtga tggatggata cccaatgcaa

1141 attacttact tctggcgggg cttgcctcct agtatcgatg cagtttatga aaatagcgac

1201 gggaattttg tgttctttaa agtgaaggga gacactctat ctgtaatcca agatggttgg

1261 ctctacaaat accattggaa atggattcta gaacaaaggc agtcagtgcc tgtgctctca

1321 agacaaactg aaaagcacaa gacctatgaa gaattatctt ccatcacata ctaacaaaga

1381 acaatcagga attgaaaatt taaaataaaa ggccatttac aattgcattc gaaaacacca

1441 aataccgagg gatcaatctg caaaaaatgt gcatgacctc tacattgaaa acaacaaaac

1501 actactaaat gtttgtcttt aaaggcagct gg

1 tagaagttta caatgaagtt tcttctaata ctgctcctgc aggccactgc ttctggagct

61 cttcccctga acagctctac aagcctggaa aaaaataatg tgctatttgg tgagagatac

121 ttagaaaaat tttatggcct tgagataaac aaacttccag tgacaaaaat gaaatatagt

181 ggaaacttaa tgaaggaaaa aatccaagaa atgcagcact tcttgggtct gaaagtgacc

241 gggcaactgg acacatctac cctggagatg atgcacgcac ctcgatgtgg agtccccgat

301 ctccatcatt tcagggaaat gccagggggg cccgtatgga ggaaacatta tatcacctac

361 agaatcaata attacacacc tgacatgaac cgtgaggatg ttgactacgc aatccggaaa

421 gctttccaag tatggagtaa tgttaccccc ttgaaattca gcaagattaa cacaggcatg

481 gctgacattt tggtggtttt tgcccgtgga gctcatggag acttccatgc ttttgatggc

541 aaaggtggaa tcctagccca tgcttttgga cctggatctg gcattggagg ggatgcacat

601 ttcgatgagg acgaattctg gactacacat tcaggaggca caaacttgtt cctcactgct

661 gttcacgaga ttggccattc cttaggtctt ggccattcta gtgatccaaa ggctgtaatg

721 ttccccacct acaaatatgt cgacatcaac acatttcgcc tctctgctga tgacatacgt

781 ggcattcagt ccctgtatgg agacccaaaa gagaaccaac gcttgccaaa tcctgacaat

841 tcagaaccag ctctctgtg.a ccccaatttg agttttgatg ctgtcactac cgtgggaaat

901 aagatctttt tcttcaaaga caggttcttc tggctgaagg tttctgagag accaaagacc

961 agtgttaatt taatttcttc cttatggcca accttgccat ctggcattga agctgcttat

1021 gaaattgaag ccagaaatca agtttttctt tttaaagatg acaaatactg gttaattagc

1081 aatttaagac cagagccaaa ttatcccaag agcatacatt cttttggttt tcctaacttt

1141 gtgaaaaaaa ttgatgcagc tgtttttaac ccacgttttt ataggaccta cttctttgta

1201 gataaccagt attggaggta tgatgaaagg agacagatga tggaccctgg ttatcccaaa

1261 ctgattacca agaacttcca aggaatcggg cctaaaattg atgcagtctt ctattctaaa

1321 aacaaatact actatttctt ccaaggatct aaccaatttg aatatgactt cctactccaa

1381 cgtatcacca aaacactgaa aagcaatagc tggtttggtt gttagaaatg gtgtaattaa

1441 tggtttttgt tagttcactt cagcttaata agtatttatt gcatatttgc tatgtcctca

1501 gtgtaccact acttagagat atgtatcata aaaataaaat ctgtaaacca taggtaatga

1561 ttatataaaa tacataatat ttttcaattt tgaaaactct aattgtccat tcttgcttga

1621 ctctactatt aagtttgaaa atagttacct tcaaagcaag ataattctat ttgaagcatg

1681 ctctgtaagt tgcttcctaa catccttgga ctgagaaatt atacttactt ctggcataac

1741 taaaattaag tatatatatt ttggctcaaa taaaattg

1 aaagaaggta agggcagtga gaatgatgca tcttgcattc cttgtgctgt tgtgtctgcc

61 agtctgctct gcctatcctc tgagtggggc agcaaaagag gaggactcca acaaggatct

121 tgcccagcaa tacctagaaa agtactacaa cctcgaaaag gatgtgaaac agtttagaag

181 aaaggacagt aatctcattg ttaaaaaaat ccaaggaatg cagaagttcc ttgggttgga

241 ggtgacaggg aagctagaca ctgacactct ggaggtgatg cgcaagccca ggtgtggagt

301 tcctgacgtt ggtcacttca gctcctttcc tggcatgccg aagtggagga aaacccacct

361 tacatacagg attgtgaatt atacaccaga tttgccaaga gatgctgttg attctgccat

421 tgagaaagct ctgaaagtct gggaagaggt gactccactc acattctcca ggctgtatga

481 aggagaggct gatataatga tctctttcgc agttaaagaa catggagact tttactcttt EPI-109 1020

541 tgatggccca ggacacagtt tggctcatgc ctacccacct ggacctgggc tttatggaga

601 tattcacttt gatgatgatg aaaaatggac agaagatgca tcaggcacca atttattcct

661 cgttgctgct catgaacttg gccactccct ggggctcttt cactcagcca acactgaagc

721 tttgatgtac ccactctaca actcattcac agagctcgcc cagttccgcc tttcgcaaga

781 tgatgtgaat ggcattcagt ctctctacgg acctccccct gcctctactg aggaacccct

841 ggtgcccaca aaatctgttc cttcgggatc tgagatgcca gccaagtgtg atcctgcttt

901 gtccttcgat gccatcagca ctctgagggg agaatatctg ttctttaaag acagatattt

961 ttggcgaaga tcccactgga accctgaacc tgaatttcat ttgatttctg cattttggcc

1021 ctctcttcca tcatatttgg atgctgcata tgaagttaac agcagggaca ccgtttttat

1081 ttttaaagga aatgagttct gggccatcag aggaaatgag gtacaagcag gttatccaag

1141 aggcatccat accctgggtt ttcctccaac cataaggaaa attgatgcag ctgtttctga

1201 caaggaaaag aagaaaacat acttctttgc agcggacaaa tactggagat ttgatgaaaa

1261 tagccagtcc atggagcaag gcttccctag actaatagct gatgactttc caggagttga

1321 gcctaaggtt gatgctgtat tacaggcatt tggatttttc tacttcttca gtggatcatc

1381 acagtttgag tttgacccca atgccaggat ggtgacacac atattaaaga gtaacagctg

1441 gttacattgc taggcgagat agggggaaga cagatatggg tgtttttaat aaatctaata

1501 attattcatc taatgtatta tgagccaaaa tggttaattt ttcctgcatg ttctgtgact

1561 gaagaagatg agccttgcag atatctgcat gtgtcatgaa gaatgtttct ggaattcttc

1621 acttgctttt gaattgcact gaacagaatt aagaaatact catgtgcaat aggtgagaga

1681 atgtattttc atagatgtgt tattacttcc tcaataaaaa gttttatttt gggcctgttc

1741 ctt

1 ctgaggtggg taagagtaca atggctaaat cttaacacac tcttacgtgt acaccctacc

61 gtacaccatc cagactcgtc cccatacaat caggagtgat cagtacgtaa atgcttatgg

121 tgtgatttga aggggtgtta gagtagatca tctctcacac cgcagcagca ctgcttccaa

181 ttcatccttt ggaattttat tccctgactg ttaaaagttt ttagtgctta aatattctct

241 attgaggtaa gagacagat.t ctgtgcaatg ggacaattag gtcaagaggg aaagaagctg

301 aggtgatagg cagatagatt ccagaggcaa acttttccca tctgctaaag ttgaaaagag

361 taacccacat cctaccaacg ctagacaatc taggatgtag ggaaagtttg tctctggaat

421 ctatccaggt acccagttgg gactgagctt cagcttagat gtctgaagat gttaagttat

481 agaatcaggt ttaagtctga agatgttaag ttatagaatc aggatctgag ccggtacaac

541 acgtggataa acaatgaagt cgatgttaca aatttttttt tgctacttgt aaaatctctg

601 tatcacattt ctctagggag ctggattccg tttaggagca ctcatttact ccaggaaaag

661 gattttattt aatctttcaa catttacttt aaaaactttt tttatctata atgaatataa

721 ggaagtatta taatgaaaac caagttatca ggctttaaga aaatatattt taagttctcc

781 ttctctttta gttgcttgat atttctttta caagggctta ttttgtagat aggtggacgt

841 agaggcttat ttatcatttt gaaggtacat actctgaatt gcttgagtga tggactagat

901 gctaattgat ccattgtcgt ctgaataaag tcatgctttt gtttgcatgt ttttagagat

961 agtcaaggga tgatatcaac tatgagtcac tcataggatt catattcaca gaacccggac

1021 taagggctat ataaagagga acagttcagg aacttaggct agaaaggaca cagtaaactg

1081 aattgatccg tttagaagtt tacaatgaag tttcttctaa tactgctcct gcaggccact

1141 gcttctggag ctcttcccct gaacagctct acaagcctgg aaaaaaataa tgtgctattg

1201 ggtgagaga

(2) INFORMATION FOR SEQ ID NO:2745: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2745

1 aaggacacgg gcagcagaca gtggtcagtc ctttcttggc tctgctgaca ctcgagccca

61 cattccgtca cctgctcaga atcatgcagg tctccactgc tgcccttgct gtcctcctct

121 gcaccatggc tctctgcaac cagttctctg catcacttgc tgctgacacg ccgaccgcct

181 gctgcttcag ctacacctcc cggcagattc cacagaattt catagctgac tactttgaga

241 cgagcagcca gtgctccaag cccggtgtca tcttcctaac caagcgaagc cggcaggtct

301 gtgctgaccc cagtgaggag tgggtccaga aatatgtcag cgacctagag ctgagtgcct

361 gaggggtcca gaagcttcga ggcccagcga cctcggtggg ccagtgggga ggagcaggag

421 cctgagcctt gggaaacatg cgtgtgacct ccacagctac ctcttctatg gactggttgt

481 tgccaaacag ccacactgtg ggactcttct taacttaaat tttaatttat ttatactatt

541 tagtttttgt aatttatttt cgatttcaca gtgtgtttgt gattgtttgc tctgagagtt

601 cccctgtccc ctcccccttc cctcacaccg cgtctggtga caaccgagtg gctgtcatca

661 gcctgtgtag gcagtcatgg caccaaagcc accagactga caaatgtgta tcggatgctt

721 ttgttcaggg ctgtgatcgg cctggggaaa taataaagca cgctctttta aaaggt

(2) INFORMATION FOR SEQ ID NO: 2746: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single EPI-109 1021

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2746

1 acagccttga ccttatgtca tgggttcaac ttggacactg aaaacgcaat gaccttccaa

61 gagaacgcaa ggggcttcgg gcagagcgtg gtccagcttc agggatccag ggtggtggtt

121 ggagcccccc aggagatagt ggctgccaac caaaggggca gcctctacca gtgcgactac

181 agcacaggct catgcgagcc catccgcctg caggtccccg tggaggccgt gaacatgtcc

241 ctgggcctgt ccctggcagc caccaccagc ccccctcagc tgctggcctg tggtcccacc

301 gtgcaccaga cttgcagtga gaacacgtat gtgaaagggc tctgcttcct gtttggatcc

361 aacctacggc agcagcccca gaagttccca gaggccctcc gagggtgtcc tcaagaggat

421 agtgacattg ccttcttgat tgatggctct ggtagcatca tcccacatga ctttcggcgg

481 atgaaggagt ttgtctcaac tgtgatggag caattaaaaa agtccaaaac cttgttctct

541 ttgatgcagt actctgaaga attccggatt cactttacct tcaaagagtt ccagaacaac

601 cctaacccaa gatcactggt gaagccaata acgcagctgc ttgggcggac acacacggcc

661 acgggcatcc gcaaagtggt acgagagctg tttaacatca ccaacggagc ccgaaagaat

721 gcctttaaga tcctagttgt catcacggat ggagaaaagt ttggcgatcc cttgggatat

781 gaggatgtca tccctgaggc agacagagag ggagtcattc gctacgtcat tggggtggga

841 gatgccttcc gcagtgagaa atcccgccaa gagcttaata ccatcgcatc caagccgcct

901 cgtgatcacg tgttccaggt gaataacttt gaggctctga agaccattca gaaccagctt

961 cgggagaaga tctttgcgat cgagggtact cagacaggaa gtagcagctc ctttgagcat

1021 gagatgtctc aggaaggctt cagcgctgcc atcacctcta atggcccctt gctgagcact

1081 gtggggagct atgactgggc tggtggagtc tttctatata catcaaagga gaaaagcacc

1141 ttcatcaaca tgaccagagt ggattcagac atgaatgatg cttacttggg ttatgctgcc

1201 gccatcatct tacggaaccg ggtgcaaagc ctggttctgg gggcacctcg atatcagcac

1261 atcggcctgg tagcgatgtt caggcagaac actggcatgt gggagtccaa cgctaatgtc

1321 aagggcaccc agatcggcgc ctacttcggg gcctccctct gctccgtgga cgtggacagc

1381 aacggcagca ccgacctggt cctcatcggg gccccccatt actacgagca gacccgaggg

1441 ggccaggtgt ccgtgtgccc cttgcccagg gggcagaggg ctcggtggca gtgtgatgct

1501 gttctctacg gggagcaggg ccaaccctgg ggccgctttg gggcagccct aacagtgctg

1561 ggggacgtaa atggggacaa gctgacggac gtggccattg gggccccagg agaggaggac

1621 aaccggggtg ctgtttacct gtttcacgga acctcaggat ctggcatcag cccctcccat

1681 agccagcgga tagcaggctc caagctctct cccaggctcc agtattttgg tcagtcactg

1741 agtgggggcc aggacctcac aatggatgga ctggtagacc tgactgtagg agcccagggg

1801 cacgtgctgc tgctcaggtc ccagccagta ctgagagtca aggcaatcat ggagttcaat

1861 cccagggaag tggcaaggaa tgtatttgag tgtaatgatc aggtggtgaa aggcaaggaa

1921 gccggagagg tcagagtctg cctccatgtc cagaagagca cacgggatcg gctaagagaa

1981 ggacagatcc agagtgttgt gacttatgac ctggctctgg actccggccg cccacattcc

2041 cgcgccgtct tcaatgagac aaagaacagc acacgcagac agacacaggt cttggggctg

2101 acccagactt gtgagaccct gaaactacag ttgccgaatt gcatcgagga cccagtgagc

2161 cccattgtgc tgcgcctgaa cttctctctg gtgggaacgc cattgtctgc tttcgggaac

2221 ctccggccag tgctggcgga ggatgctcag agactcttca cagccttgtt tccctttgag

2281 aagaattgtg gcaatgacaa catctgccag gatgacctca gcatcacctt cagtttcatg

2341 agcctggact gcctcgtggt gggtgggccc cgggagttca acgtgacagt gactgtgaga

2401 aatgatggtg aggactccta caggacacag gtcaccttct tcttcccgct tgacctgtcc

2461 taccggaagg tgtccacgct ccagaaccag cgctcacagc gatcctggcg cctggcctgt

2521 gagtctgcct cctccaccga agtgtctggg gccttgaaga gcaccagctg cagcataaac

2581 caccccatct tcccggaaaa ctcagaggtc acctttaata tcacgtttga tgtagactct

2641 aaggcttccc ttggaaacaa actgctcctc aaggccaatg tgaccagtga gaacaacatg

2701 cccagaacca acaaaaccga attccaactg gagctgccgg tgaaatatgc tgtctacatg

2761 gtggtcacca gccatggggt ctccactaaa tatctcaact tcacggcctc agagaatacc

2821 agtcgggtca tgcagcatca atatcaggtc agcaacctgg ggcagaggag cctccccatc

2881 agcctggtgt tcttggtgcc cgtccggctg aaccagactg tcatatggga ccgcccccag

2941 gtcaccttct ccgagaacct ctcgagtacg tgccacacca aggagcgctt gccctctcac

3001 tccgactttc tggctgagct tcggaaggcc cccgtggtga actgctccat cgctgtctgc

3061 cagagaatcc agtgtgacat cccgttcttt ggcatccagg aagaattcaa tgctaccctc

3121 aaaggcaacc tctcgtttga ctggtacatc aagacctcgc ataaccacct cctgatcgtg

3181 agcacagctg agatcttgtt taacgattcc gtgttcaccc tgctgccggg acagggggcg

3241 tttgtgaggt cccagacgga gaccaaagtg gagccgttcg aggtccccaa ccccctgccg

3301 ctcatcgtgg gcagctctgt cgggggactg ctgctcctgg ccctcatcac cgccgcgctg

3361 tacaagctcg gcttcttcaa gcggcaatac aaggacatga tgagtgaagg gggtcccccg

3421 ggggccgaac cccagtagcg gctccttccc gacagagctg cctctcggtg gccagcagga

3481 ctctgcccag accacacgta gcccccaggc tgctggacac gtcggacagc gaagtatccc

3541 cgacaggacg ggcttgggct tccatttgtg tgtgtgcaag tgtgtatgtg cgtgtgtgcg

3601 agtgtgtgca agtgtctgtg tgcaagtgtg tgcacgtgtc ggtgtgcgtg catgtgcact

3661 cgcacgccca tgtgtgagtg tgtgcaagta tgtgagtgtg tccaagtgtg tgtgcgtgtg

3721 tccatgtgtg tgcaagtgtg tgcatgtgtg cgagtgtgtg catgtgtgtg ctcaggggcg

3781 tgtggctcac gtgtgtgact cagatgtctc tggcgtgtgg gtaggtgacg gccagcgtag

3841 cctctccggc agaagggaac tgcctgggct cccttgtgcg tgggtgaagc cgctgctggg

3901 ttttcctccg ggagagggga cggtcaatcc tgtgggtgaa gacagaggga aacacagcag EPI-109 1022

3961 cttctctcca ctgaaagaag tgggacttcc cgtcgcctgc agcctgcggc ctgctggagc 4021 ctgcgcagct tggatggaga ctccatgaga agccgtgggt ggaaccagga gcctcctcca 4081 caccagcgct gatgcccaat aaagatgccc actgaggaat gatg

(2) INFORMATION FOR SEQ ID NO:2747: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2747

1 agcaggaagc tcgcgccgcc gtcgccgccg ccgctcagct tccccgggcg cgtccaggac

61 ccgctgcgcc aggcgcgccg tccccggacc cggcgtgcgt ccctacgagg aaagggaccc

121 cgccgctcga gccgcctccg ccagccccac tgcgaggggt cccagagcca gccgcgcccg

181 ccctcgcccc cggccccgca gccttcccgc cctgcgcgcc atgaacgccc ccgagcggca

241 gccccaaccc gacggcgggg acgccccagg ccacgagcct gggggcagcc cccaagacga

301 gcttgacttc tccatcctct tcgactatga gtatttgaat ccgaacgaag aagagccgaa

361 tgcacataag gtcgccagcc caccctccgg acccgcatac cccgatgatg taatggacta

421 tggcctcaag ccatacagcc cccttgctag tctctctggc gagccccccg gccgattcgg

481 agagccggat agggtagggc cgcagaagtt tctgagcgcg gccaagccag caggggcctc

541 gggcctgagc cctcggatcg agatcactcc gtcccacgaa ctgatccagg cagtggggcc

601 cctccgcatg agagacgcgg gcctcctggt ggagcagcct cccctggccg gggtggccgc

661 cagcccgagg ttcaccctgc ccgtgcccgg cttcgagggc taccgcgagc cgctttgctt

721 gagccccgct agcagcggct cctctgccag cttcatttct gacaccttct ccccctacac

781 ctcgccctgc gtctcgccca ataacggcgg gcccgacgac ctgtgtccgc agtttcaaaa

841 catccctgct cattattccc ccagaacctc gccaataatg tcacctcgaa ccagcctcgc

901 cgaggacagc tgcctgggcc gccactcgcc cgtgccccgt ccggcctccc gctcctcatc

961 gcctggtgcc aagcggaggc attcgtgcgc cgaggccttg gttgccctgc cgcccggagc

1021 ctcaccccag cgctcccgga gcccctcgcc gcagccctca tctcacgtgg caccccagga

1081 ccacggctcc ccggctgggt acccccctgt ggctggctct gccgtgatca tggatgccct

1141 gaacagcctc gccacggact cgccttgtgg gatccccccc aagatgtgga agaccagccc

1201 tgacccctcg ccggtgtctg ccgccccatc caaggccggc ctgcctcgcc acatctaccc

1261 ggccgtggag ttcctggggc cctgcgagca gggcgagagg agaaactcgg ctccagaatc

1321 catcctgctg gttccgccca cttggcccaa gccgctggtg cctgccattc ccatctgcag

1381 catcccagtg actgcatccc tccctccact tgagtggccg ctgtccagtc agtcaggctc

1441 ttacgagctg cggatcgagg tgcagcccaa gccacatcac cgggcccact atgagacaga

1501 aggcagccga ggggctgtca aagctccaac tggaggccac cctgtggttc agctccatgg

1561 ctacatggaa aacaagcctc tgggacttca gatcttcatt gggacagctg atgagcggat

1621 ccttaagccg cacgccttct accaggtgca ccgaatcacg gggaaaactg tcaccaccac

1681 cagctatgag aagatagtgg gcaacaccaa agtcctggag atccccttgg agcccaaaaa

1741 caacatgagg gcaaccatcg actgtgcggg gatcttgaag cttagaaacg ccgacattga

1801 gctgcggaaa ggcgagacgg acattggaag aaagaacacg cgggtgagac tggttttccg

1861 agttcacatc ccagagtcca gtggcagaat cgtctcttta cagactgcat ctaaccccat

1921 cgagtgctcc cagcgatctg ctcacgagct gcccatggtt gaaagacaag acacagacag

1981 ctgcctggtc tatggcggcc agcaaatgat cctcacgggg cagaacttta catccgagtc

2041 caaagttgtg tttactgaga agaccacaga tggacagcaa atttgggaga tggaagccac

2101 ggtggataag gacaagagcc agcccaacat gctttttgtt gagatccctg aatatcggaa

2161 caagcatatc cgcacacctg taaaagtgaa cttctacgtc atcaatggga agagaaaacg

2221 aagtcagcct cagcacttta cctaccaccc agtcccagcc atcaagacgg agcccacgga

2281 tgaatatgac cccactctga tctgcagccc cacccatgga ggcctgggga gccagcctta

2341 ctacccccag cacccgatgg tggccgagtc cccctcctgc ctcgtggcca ccatggctcc

2401 ctgccagcag ttccgcacgg ggctctcatc ccctgacgcc cgctaccagc aacagaaccc

2461 agcggccgta ctctaccagc ggagcaagag cctgagcccc agcctgctgg gctatcagca

2521 gccggccctc atggccgccc cgctgtccct tgcggacgct caccgctctg tgctggtgca

2581 cgccggctcc cagggccaga gctcagccct gctccacccc tctccgacca accagcaggc

2641 ctcgcctgtg atccactact cacccaccaa ccagcagctg cgctgcggaa gccaccagga

2701 gttccagcac atcatgtact gcgagaattt cgcaccaggc accaccagac ctggcccgcc

2761 cccggtcagt caaggtcaga ggctgagccc gggttcctac cccacagtca ttcagcagca

2821 gaatgccacg agccaaagag ccgccaaaaa cggacccccg gtcagtgacc aaaaggaagt

2881 attacctgcg ggggtgacca ttaaacagga gcagaacttg gaccagacct acttggatga

2941 tgttaatgaa attatcagga aggagttttc aggacctcct gccagaaatc agacgtaa

(2) INFORMATION FOR SEQ ID NO: 2748: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2748 EPI-109 1023

1 gctgcagcac cctgggccac gccgatgact actgcaaact gtggcgccca cgacgagctc

61 gacttcaaac tcgtctttgg cgaggacggg gcgccggcgc cgccgccccc gggctcgcgg

121 cctgcagatc ttgagccaga tgattgtgca tccatttaca tctttaatgt agatccacct

181 ccatctactt taaccacacc actttgctta ccacatcatg gattaccgtc tcactcttct

241 gttttgtcac catcgtttca gctccaaagt cacaaaaact atgaaggaac ttgtgagatt

301 cctgaatcta aatatagccc attaggtggt cccaaaccct ttgagtgccc aagtattcaa

361 attacatcta tctctcctaa ctgtcatcaa gaattagatg cacatgaaga tgacctacag

421 ataaatgacc cagaacggga atttttggaa aggccttcta gagatcatct ctatcttcct

481 cttgagccat cctaccggga gtcttctctt agtcctagtc ctgccagcag catctcttct

541 aggagttggt tctctgatgc atcttcttgt gaatcgcttt cacatattta tgatgatgtg

601 gactcagagt tgaatgaagc tgcagcccga tttacccttg gatcccctct gacttctcct

661 ggtggctctc cagggggctg ccctggagaa gaaacttggc atcaacagta tggacttgga

721 cactcattat cacccaggca atctccttgc cactctccta gatccagtgt cactgatgag

781 aattggctga gccccaggcc agcctcagga ccctcatcaa ggcccacatc cccctgtggg

841 aaacggaggc actccagtgc tgaagtttgt tatgctgggt ccctttcacc ccatcactca

901 cctgttcctt cacctggtca ctcccccagg ggaagtgtga cagaagatac gtggctcaat

961 gcttctgtcc atggtgggtc aggccttggc cctgcagttt ttccatttca gtactgtgta

1021 gagactgaca tccctctcaa aacaaggaaa acttctgaag atcaagctgc catactacca

1081 ggaaaattag agctgtgttc agatgaccaa gggagtttat caccagcccg ggagacttca

1141 atagatgatg gccttggatc tcagtatcct ttaaagaaag attcatgtgg tgatcagttt

1201 ctttcagttc cttcaccctt tacctggagc aaaccaaagc ctggccacac ccctatattt

1261 cgcacatctt cattacctcc actagactgg cctttaccag ctcattttgg acaatgtgaa

1321 ctgaaaatag aagtgcaacc taaaactcat catcgagccc attatgaaac tgaaggtagc

1381 cgaggggcag taaaagcatc tactggggga catcctgttg tgaagctcct gggctataac

1441 gaaaagccaa taaatctaca aatgtttatt gggacagcag atgatcgata tttacgacct

1501 catgcatttt accaggtgca tcgaatcact gggaagacag tcgctactgc aagccaagag

1561 ataataattg ccagtacaaa agttctggaa attccacttc ttcctgaaaa taatatgtca

1621 gccagtattg attgtgcagg tattttgaaa ctccgcaatt cagatataga acttcgaaaa

1681 ggagaaactg atattggcag aaagaatact agagtacgac ttgtgtttcg tgtacacatc

1741 ccacagccca gtggaaaagt cctttctctg cagatagcct ctatacccgt tgagtgctcc

1801 cagcggtctg ctcaagaact tcctcatatt gagaagtaca gtatcaacag ttgttctgta

1861 aatggaggtc atgaaatggt tgtgactgga tctaattttc ttccagaatc caaaatcatt

1921 tttcttgaaa aaggacaaga tggacgacct cagtgggagg tagaagggaa gataatcagg

1981 gaaaaatgtc aaggggctca cattgtcctt gaagttcctc catatcataa cccagcagtt

2041 acagctgcag tgcaggtgca cttttatctt tgcaatggca agaggaaaaa aagccagtct

2101 caacgtttta cttatacacc agttttgctg aagcaagaac acagagaaga gattgatttg

2161 tcttcagttc catctttgcc tgtgcctcat cctgctcaga cccagaggcc ttcctctgat

2221 tcagggtgtt cacatgacag tgtactgtca ggacagagaa gtttgatttg ctccatccca

2281 caaacatatg catccatggt gacctcatcc catctgccac agttgcagtg tagagatgag

2341 agtgttagta aagaacagca tatgattcct tctccaattg tacaccagcc ttttcaagtc

2401 acaccaacac ctcctgtggg gtcttcctat cagcctatgc aaactaatgt tgtgtacaat

2461 ggaccaactt gtcttcctat taatgctgcc tctagtcaag aatttgattc agtttggttt

2521 cagcaggatg caactctttc tggtttagtg aatcttggct gtcaaccact gtcatccata

2581 ccatttcatt cttcaaattc aggctcaaca ggacatctct tagcccatac acctcattct

2641 gtgcataccc tgcctcatct gcaatcaatg ggatatcatt gttcaaatac aggacaaaga

2701 tctctttctt ctccagtggg tgaccagatt acaggtcagc cttcgtctca gttacaacct

2761 attacatatg gtccttcaca ttcagggtct gttacaacag cttccccagc agcttctcat

2821 cccttgggta gttcaccgct ttctgggcca ccatctcctc agtttcagcc tatgccttac

2881 caatctccta gctcaggaac tggctcatca ccgtctccag ccaccagaat gcattctgga

2941 cagcactcaa ctcaagcaca aagtacgggc caggggggtc tttctgcacc ttcatcctta

3001 atatgtcaca gtttgtgtga tccagcgtca tttccacctg atggggcaac tgtgagcatt

3061 aaacctgaac cagaagatcg agagcctaac tttgcaacca ttggtctgca ggacatcact

3121 ttagatgatg accaatttat atctgacttg gaacaccagc catcaggttc agcagagaaa

3181 tggcctaacc acagtgtgct ctcatgtcca gctcctttct ggagaatcta gaggtgaacg

3241 agataattgg gagagacatg tcccagattt ctgtttccca aggagcaggg gtgagcaggc

3301 aggctcccct cccgagtcct gagtccctgg atttaggaag atctgatggg ctctaacagt

3361 gcttactgca gccttgtgtc caccaccaac ttctcagcat gtttctctcc ttggaccttg

3421 ggtttccaac tcttcaacct tcaggtctgg ggccaggagt gggacccacc atttgtgggg

3481 aaagtagcat tcctccacct caggccttgg gtagatttgg caaaagaaca ggagcagcat

3541 aggctgtttg agctttgggg aaatgaactt tgctttttat atttaactag gatactttta

3601 aatgatgggt gctttgagtg tgaatccagc aggctctctt gtttccgagg tgctgctttt

3661 gcaggtgacc tggttactta actaggagtg gtgatttgta ctgctttatg gtcatttgaa

3721 gggcccttta gtttttatga taatttttaa aataggaact tttgataaga ccttctagaa

3781 gcaa

(2) INFORMATION FOR SEQ ID NO: 2749: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid EPI-109 1024

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2749 1 gctgcagcac cctgggccac gccgatgact actgcaaact gtggcgccca cgacgagctc

61 gacttcaaac tcgtctttgg cgaggacggg gcgccggcgc cgccgccccc gggctcgcgg

121 cctgcagatc ttgagccaga tgattgtgca tccatttaca tctttaatgt agatccacct

181 ccatctactt taaccacacc actttgctta ccacatcatg gattaccgtc tcactcttct

241 gttttgtcac catcgtttca gctccaaagt cacaaaaact atgaaggaac ttgtgagatt

301 cctgaatcta aatatagccc attaggtggt cccaaaccct ttgagtgccc aagtattcaa

361 attacatcta tctctcctaa ctgtcatcaa gaattagatg cacatgaaga tgacctacag

421 ataaatgacc cagaacggga atttttggaa aggccttcta gagatcatct ctatcttcct

481 cttgagccat cctaccggga gtcttctctt agtcctagtc ctgccagcag catctcttct

541 aggagttggt tctctgatgc atcttcttgt gaatcgcttt cacatattta tgatgatgtg

601 gactcagagt tgaatgaagc tgcagcccga tttacccttg gatcccctct gacttctcct

661 ggtggctctc cagggggctg ccctggagaa gaaacttggc atcaacagta tggacttgga

721 cactcattat cacccaggca atctccttgc cactctccta gatccagtgt cactgatgag

781 aattggctga gccccaggcc agcctcagga ccctcatcaa ggcccacatc cccctgtggg

841 aaacggaggc actccagtgc tgaagtttgt tatgctgggt ccctttcacc ccatcactca

901 cctgttcctt cacctggtca ctcccccagg ggaagtgtga cagaagatac gtggctcaat

961 gcttctgtcc atggtgggtc aggccttggc cctgcagttt ttccatttca gtactgtgta

1021 gagactgaca tccctctcaa aacaaggaaa acttctgaag atcaagctgc catactacca

1081 ggaaaattag agctgtgttc agatgaccaa gggagtttat caccagcccg ggagacttca

1141 atagatgatg gccttggatc tcagtatcct ttaaagaaag attcatgtgg tgatcagttt

1201 ctttcagttc cttcaccctt tacctggagc aaaccaaagc ctggccacac ccctatattt

1261 cgcacatctt cattacctcc actagactgg cctttaccag ctcattttgg acaatgtgaa

1321 ctgaaaatag aagtgcaacc taaaactcat catcgagccc attatgaaac tgaaggtagc

1381 cgaggggcag taaaagcatc tactggggga catcctgttg tgaagctcct gggctataac

1441 gaaaagccaa taaatctaca aatgtttatt gggacagcag atgatcgata tttacgacct

1501 catgcatttt accaggtgca tcgaatcact gggaagacag tcgctactgc aagccaagag

1561 ataataattg ccagtacaaa agttctggaa attccacttc ttcctgaaaa taatatgtca

1621 gccagtattg attgtgcagg tattttgaaa ctccgcaatt cagatataga acttcgaaaa

1681 ggagaaactg atattggcag aaagaatact agagtacgac ttgtgtttcg tgtacacatc

1741 ccacagccca gtggaaaagt cctttctctg cagatagcct ctatacccgt tgagtgctcc

1801 cagcggtctg ctcaagaact tcctcatatt gagaagtaca gtatcaacag ttgttctgta

1861 aatggaggtc atgaaatggt tgtgactgga tctaattttc ttccagaatc caaaatcatt

1921 tttcttgaaa aaggacaaga tggacgacct cagtgggagg tagaagggaa gataatcagg

1981 gaaaaatgtc aaggggctca cattgtcctt gaagttcctc catatcataa cccagcagtt

2041 acagctgcag tgcaggtgca cttttatctt tgcaatggca agaggaaaaa aagccagtct

2101 caacgtttta cttatacacc agttttgctg aagcaagaac acagagaaga gattgatttg

2161 tcttcagttc catctttgcc tgtgcctcat cctgctcaga cccagaggcc ttcctctgat

2221 tcagggtgtt cacatgacag tgtactgtca ggacagagaa gtttgatttg ctccatccca

2281 caaacatatg catccatggt gacctcatcc catctgccac agttgcagtg tagagatgag

2341 agtgttagta aagaacagca tatgattcct tctccaattg tacaccagcc ttttcaagtc

2401 acaccaacac ctcctgtggg gtcttcctat cagcctatgc aaactaatgt tgtgtacaat

2461 ggaccaactt gtcttcctat taatgctgcc tctagtcaag aatttgattc agtttggttt

2521 cagcaggatg caactctttc tggtttagtg aatcttggct gtcaaccact gtcatccata

2581 ccatttcatt cttcaaattc aggctcaaca ggacatctct tagcccatac acctcattct

2641 gtgcataccc tgcctcatct gcaatcaatg ggatatcatt gttcaaatac aggacaaaga

2701 tctctttctt ctccagtggg tgaccagatt acaggtcagc cttcgtctca gttacaacct

2761 attacatatg gtccttcaca ttcagggtct gttacaacag cttccccagc agcttctcat

2821 cccttgggta gttcaccgct ttctgggcca ccatctcctc agtttcagcc tatgccttac

2881 caatctccta gctcaggaac tggctcatca ccgtctccag ccaccagaat gcattctgga

2941 cagcactcaa ctcaagcaca aagtacgggc caggggggtc tttctgcacc ttcatcctta

3001 atatgtcaca gtttgtgtga tccagcgtca tttccacctg atggggcaac tgtgagcatt

3061 aaacctgaac cagaagatcg agagcctaac tttgcaacca ttggtctgca ggacatcact

3121 ttagatgatg atttgtttac cagtaataat tttgacttgc ttcagttgag acctacgttt

3181 tggccagtcc cagcaggaag atatctgagg aatctagagt gaacgagata attgggagag

3241 acatgtccca gatttctgtt tcccaaggag caggggtgag caggcaggct cccctcccga

3301 gtcctgagtc cctggattta ggaagatctg atgggctcta acagtgctta ctgcagcctt

3361 gtgtccacca ccaacttctc agcatgtttc tctccttgga ccttgggttt ccaactcttc

3421 aaccttcagg tctggggcca ggagtgggac ccaccatttg tggggaaagt agcattcctc

3481 cacctcaggc cttgggtaga tttggcaaaa gaacaggagc agcataggct gtttgagctt

3541 tggggaaatg aactttgctt tttatattta actaggatac ttttaaatga tgggtgcttt

3601 gagtgtgaat ccagcaggct ctcttgtttc cgaggtgctg cttttgcagg tgacctggtt

3661 acttaactag gagtggtgat ttgtactgct ttatggtcat ttgaagggcc ctttagtttt

3721 tatgataatt tttaaaatag gaacttttga taagaccttc tagaagcaa

(2) INFORMATION FOR SEQ ID NO: 2750: (i) SEQUENCE CHARACTERISTICS: EPI-109 1025

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2750

1 gctgcagcac cctgggccac gccgatgact actgcaaact gtggcgccca cgacgagctc

61 gacttcaaac tcgtctttgg cgaggacggg gcgccggcgc cgccgccccc gggctcgcgg

121 cctgcagatc ttgagccaga tgattgtgca tccatttaca tctttaatgt agatccacct

181 ccatctactt taaccacacc actttgctta ccacatcatg gattaccgtc tcactcttct

241 gttttgtcac catcgtttca gctccaaagt cacaaaaact atgaaggaac ttgtgagatt

301 cctgaatcta aatatagccc attaggtggt cccaaaccct ttgagtgccc aagtattcaa

361 attacatcta tctctcctaa ctgtcatcaa gaattagatg cacatgaaga tgacctacag

421 ataaatgacc cagaacggga atttttggaa aggccttcta gagatcatct ctatcttcct

481 cttgagccat cctaccggga gtcttctctt agtcctagtc ctgccagcag catctcttct

541 aggagttggt tctctgatgc atcttcttgt gaatcgcttt cacatattta tgatgatgtg

601 gactcagagt tgaatgaagc tgcagcccga tttacccttg gatcccctct gacttctcct

661 ggtggctctc cagggggctg ccctggagaa gaaacttggc atcaacagta tggacttgga

721 cactcattat cacccaggca atctccttgc cactctccta gatccagtgt cactgatgag

781 aattggctga gccccaggcc agcctcagga ccctcatcaa ggcccacatc cccctgtggg

841 aaacggaggc actccagtgc tgaagtttgt tatgctgggt ccctttcacc ccatcactca

901 cctgttcctt cacctggtca ctcccccagg ggaagtgtga cagaagatac gtggctcaat

961 gcttctgtcc atggtgggtc aggccttggc cctgcagttt ttccatttca gtactgtgta

1021 gagactgaca tccctctcaa aacaaggaaa acttctgaag atcaagctgc catactacca

1081 ggaaaattag agctgtgttc agatgaccaa gggagtttat caccagcccg ggagacttca

1141 atagatgatg gccttggatc tcagtatcct ttaaagaaag attcatgtgg tgatcagttt

1201 ctttcagttc cttcaccctt tacctggagc aaaccaaagc ctggccacac ccctatattt

1261 cgcacatctt cattacctcc actagactgg cctttaccag ctcattttgg acaatgtgaa

1321 ctgaaaatag aagtgcaacc taaaactcat catcgagccc attatgaaac tgaaggtagc

1381 cgaggggcag taaaagcatc tactggggga catcctgttg tgaagctcct gggctataac

1441 gaaaagccaa taaatctaca aatgtttatt gggacagcag atgatcgata tttacgacct

1501 catgcatttt accaggtgca tcgaatcact gggaagacag tcgctactgc aagccaagag

1561 ataataattg ccagtacaaa agttctggaa attccacttc ttcctgaaaa taatatgtca

1621 gccagtattg attgtgcagg tattttgaaa ctccgcaatt cagatataga acttcgaaaa

1681 ggagaaactg atattggcag aaagaatact agagtacgac ttgtgtttcg tgtacacatc

1741 ccacagccca gtggaaaagt cctttctctg cagatagcct ctatacccgt tgagtgctcc

1801 cagcggtctg ctcaagaact tcctcatatt gagaagtaca gtatcaacag ttgttctgta

1861 aatggaggtc atgaaatggt tgtgactgga tctaattttc ttccagaatc caaaatcatt

1921 tttcttgaaa aaggacaaga tggacgacct cagtgggagg tagaagggaa gataatcagg

1981 gaaaaatgtc aaggggctca cattgtcctt gaagttcctc catatcataa cccagcagtt

2041 acagctgcag tgcaggtgca cttttatctt tgcaatggca agaggaaaaa aagccagtct

2101 caacgtttta cttatacacc agttttgctg aagcaagaac acagagaaga gattgatttg

2161 tcttcagttc catctttgcc tgtgcctcat cctgctcaga cccagaggcc ttcctctgat

2221 tcagggtgtt cacatgacag tgtactgtca ggacagagaa gtttgatttg ctccatccca

2281 caaacatatg catccatggt gacctcatcc catctgccac agttgcagtg tagagatgag

2341 agtgttagta aagaacagca tatgattcct tctccaattg tacaccagcc ttttcaagtc

2401 acaccaacac ctcctgtggg gtcttcctat cagcctatgc aaactaatgt tgtgtacaat

2461 ggaccaactt gtcttcctat taatgctgcc tctagtcaag aatttgattc agtttggttt

2521 cagcaggatg caactctttc tggtttagtg aatcttggct gtcaaccact gtcatccata

2581 ccatttcatt cttcaaattc aggctcaaca ggacatctct tagcccatac acctcattct

2641 gtgcataccc tgcctcatct gcaatcaatg ggatatcatt gttcaaatac aggacaaaga

2701 tctctttctt ctccagtggg tgaccagatt acaggtcagc cttcgtctca gttacaacct

2761 attacatatg gtccttcaca ttcagggtct gttacaacag cttccccagc agcttctcat

2821 cccttgggta gttcaccgct ttctgggcca ccatctcctc agtttcagcc tatgccttac

2881 caatctccta gctcaggaac tggctcatca ccgtctccag ccaccagaat gcattctgga

2941 cagcactcaa ctcaagcaca aagtacgggc caggggggtc tttctgcacc ttcatcctta

3001 atatgtcaca gtttgtgtga tccagcgtca tttccacctg atggggcaac tgtgagcatt

3061 aaacctgaac cagaagatcg agagcctaac tttgcaacca ttggtctgca ggacatcact

3121 ttagatgatg gtaagttcat ctctgatatg ttcttgaagt agtgaagatt cagggacttt

3181 attctcccaa gtgtcatgaa aaagtttcta tggattgctt attggcatat ggttgggctt

3241 ttaaataagt tgttattaga aatatatgtt aatatataac tttgccaggt accacggctc

3301 acgcctgtat cccagcactt tggaaggctg aggcgggtgg atcacaaggt caggagttca

3361 agaccagcct ggccaacatg gtgtaacgct gtctctacta aaaatacaaa aaattagcca

3421 ggcatggtgg tgtgtgacta taatcccagc tactcgggag gctgagacag gagaatcact

3481 tgaacccggg aggtggcagt tgcagggagc taagatcgcg ccattgcact ccagcctggg

3541 cggcagagca agactccgtc tcgggaaaaa aaaaaaaaaa aaa

(2) INFORMATION FOR SEQ ID NO: 2751:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: base pairs EPI-109 1026

( B) TYPE : nucleic acid

( C ) STRANDEDNESS : single

( D) TOPOLOGY : linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2751

1 gaattccggg ccgggagaac cgaacccctg gcggccgcga ccccggctcc cgccccggcc

61 ccggcccgac ccgccatgac ggggctggag gaccaggagt tcgacttcga gttcctcttc

121 gagtttaacc agcgcgacga gggcgccgcc gcggccgccc cagaacacta tggctatgca

181 tcctccaacg tcagccccgc cctgccgctc cccacggcgc actccaccct gccggccccg

241 tgccacaacc ttcagacctc cacaccgggc atcatcccgc cggcggatca cccctcgggg

301 tacggagcag ctttggacgg tgggcctgcg ggctacttcc tctcctccgg ccacaccagg

361 cctgatgggg cccctgccct ggagagtcct cgcatcgaga taacctcgtg cttgggcctg

421 taccacaaca ataaccagtt tttccacgat gtggaggtgg aagacgtcct ccctagctcc

481 aaacggtccc cctccacggc cacgctgagt ctgcccagcc tggaggccta cagagacccc

541 tcgtgcctga gcccggccag cagcctgtcc tcccggagct gcaactcaga ggcctcctcc

601 tacgagtcca actactcgta cccgtacgcg tccccccaga cgtcgccatg gcagtctccc

661 tgcgtgtctc ccaagaccac ggaccccgag gagggctttc cccgcgggct gggggcctgc

721 acactgctga gttccccgcg gcactccccc tccacctcgc cccgcgccag cgtcactgag

781 gagagctggc tgggtgcccg ctcctccaga cccgcgtccc cttgcaacaa gaggaagtac

841 agcctcaacg gccggcagcc gccctactca ccccaccact cgcccacgcc atccccgcac

901 ggctccccgc gggtcagcgt gaccgacgac tcgtggttgg gcaacaccac ccagtacacc

961 agctcggcca tcgtggccgc catcaacgcg ctgaccaccg acagcagcct ggacctggga

1021 gatggcgtcc ctgtcaagtc ccgcaagacc accctggagc agccgccctc agtggcgctc

1081 aaggtggagc ccgtcgggga ggacctgggc agccccccgc ccccggccga cttcgcgccc

1141 gaagactact cctctttcca gcacatcagg aagggcggct tctgcgacca gtacctggcg

1201 gtgccgcagc acccctacca gtgggcgaag cccaagcccc tgtcccctac gtcctacatg

1261 agcccgaccc tgcccgccct ggactggcag ctgccgtccc actcaggccc gtatgagctt

1321 cggattgagg tgcagcccaa gtcccaccac cgagcccact acgagacgga gggcagccgg

1381 ggggccgtga aggcgtcggc cggaggacac cccatcgtgc agctgcatgg ctacttggag

1441 aatgagccgc tgatgctgca gcttttcatt gggacggcgg acgaccgcct gctgcgcccg

1501 cacgccttct accaggtgca ccgcatcaca gggaagaccg tgtccaccac cagccacgag

1561 gccatcctct ccaacaccaa agtcctggag atcccactcc tgccggagaa cagcatgcga

1621 gccgtcattg actgtgccgg aatcctgaaa ctcagaaact ccgacattga acttcggaaa

1681 ggagagacgg acatcgggag gaagaacaca cgggtacggc tggtgttccg cgttcacgtc

1741 ccgcaaccca gcggccgcac gctgtccctg caggtggcct ccaaccccat cgaatgctcc

1801 cagcgctcag ctcaggagct gcctctggtg gagaagcaga gcacggacag ctatccggtc

1861 gtgggcggga agaagatggt cctgtctggc cacaacttcc tgcaggactc caaggtcatt

1921 ttcgtggaga aagccccaga tggccaccat gtctgggaga tggaagcgaa aactgaccgg

1981 gacctgtgca agccgaattc tctggtggtt gagatcccgc cgtttcggaa tcagaggata

2041 accagccccg ttcacgtcag tttctacgtc tgcaacggga agagaaagcg aagccagtac

2101 cagcgtttca cctaccttcc cgccaacgtt ccaattataa aaacagaacc cactgatgat

2161 tatgagcctg ctccaacctg tggaccggtg agccaggggt taagtcctct cccaagacca

2221 tactacagcc agcagctcgc gatgccaccc gaccccagct cctgcctcgt ggccggcttc

2281 ccgccctgtc cgcagagaag caccctgatg ccagcggccc ctggcgtgag ccccaagctc

2341 cacgaccttt ctcccgctgc ctacaccaag ggcgttgcca gcccgggcca ctgtcacctc

2401 ggactcccgc agccggccgg agaggccccc gccgtccagg acgtgcccag gccagtggcc

2461 acgcaccccg gctcgcccgg gcagccaccc ccggccctgc tgccacagca gtaaatgaaa

2521 taatacgaaa tgacctctcc agcacgagca cccactccta gttgccacat tggagcactc

2581 agttcagcag gggtatgctg acttcagcag acaaagactt ttgaataaat aaactgaact

2641 cacacctggt accactcaga acctccaact gactgaatgc caggagctga acattaatat

2701 gtgcaaagat tggctctcca acaagaagga aagcagggag gaagggagac cactgtgtcg

2761 cctggaggag aagtcatctc atgacaacag aagggaggtg gccgggctga gcacggagac

2821 ccaccgtgca ggggcctttc atgggaacgg cccacacgca gtttgacccc acgcccagcc

2881 cttctggcac ccctggggtt caatactgga agtgccttat ttaaccagac catca

(2) INFORMATION FOR SEQ ID NO:2752: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2752

1 agcaggaagc tcgcgccgcc gtcgccgccg ccgctcagct tccccgggcg cgtccaggac

61 ccgctgcgcc aggcgcgccg tccccggacc cggcgtgcgt ccctacgagg aaagggaccc

121 cgccgctcga gccgcctccg ccagccccac tgcgaggggt cccagagcca gccgcgcccg

181 ccctcgcccc cggccccgca gccttcccgc cctgcgcgcc atgaacgccc ccgagcggca

241 gccccaaccc gacggcgggg acgccccagg ccacgagcct gggggcagcc cccaagacga

301 gcttgacttc tccatcctct tcgactatga gtatttgaat ccgaacgaag aagagccgaa

361 tgcacataag gtcgccagcc caccctccgg acccgcatac cccgatgatg taatggacta

421 tggcctcaag ccatacagcc cccttgctag tctctctggc gagccccccg gccgattcgg EPI-109 1027

481 agagccggat agggtagggc cgcagaagtt tctgagcgcg gccaagccag caggggcctc

541 gggcctgagc cctcggatcg agatcactcc gtcccacgaa ctgatccagg cagtggggcc

601 cctccgcatg agagacgcgg gcctcctggt ggagcagcct cccctggccg gggtggccgc

661 cagcccgagg ttcaccctgc ccgtgcccgg cttcgagggc taccgcgagc cgctttgctt

721 gagccccgct agcagcggct cctctgccag cttcatttct gacaccttct ccccctacac

781 ctcgccctgc gtctcgccca ataacggcgg gcccgacgac ctgtgtccgc agtttcaaaa

841 catccctgct cattattccc ccagaacctc gccaataatg tcacctcgaa ccagcctcgc

901 cgaggacagc tgcctgggcc gccactcgcc cgtgccccgt ccggcctccc gctcctcatc

961 gcctggtgcc aagcggaggc attcgtgcgc cgaggccttg gttgccctgc cgcccggagc

1021 ctcaccccag cgctcccgga gcccctcgcc gcagccctca tctcacgtgg caccccagga

1081 ccacggctcc ccggctgggt acccccctgt ggctggctct gccgtgatca tggatgccct

1141 gaacagcctc gccacggact cgccttgtgg gatccccccc aagatgtgga agaccagccc

1201 tgacccctcg ccggtgtctg ccgccccatc caaggccggc ctgcctcgcc acatctaccc

1261 ggccgtggag ttcctggggc cctgcgagca gggcgagagg agaaactcgg ctccagaatc

1321 catcctgctg gttccgccca cttggcccaa gccgctggtg cctgccattc ccatctgcag

1381 catcccagtg actgcatccc tccctccact tgagtggccg ctgtccagtc agtcaggctc

1441 ttacgagctg cggatcgagg tgcagcccaa gccacatcac cgggcccact atgagacaga

1501 aggcagccga ggggctgtca aagctccaac tggaggccac cctgtggttc agctccatgg

1561 ctacatggaa aacaagcctc tgggacttca gatcttcatt gggacagctg atgagcggat

1621 ccttaagccg cacgccttct accaggtgca ccgaatcacg gggaaaactg tcaccaccac

1681 cagctatgag aagatagtgg gcaacaccaa agtcctggag atccccttgg agcccaaaaa

1741 caacatgagg gcaaccatcg actgtgcggg gatcttgaag cttagaaacg ccgacattga

1801 gctgcggaaa ggcgagacgg acattggaag aaagaacacg cgggtgagac tggttttccg

1861 agttcacatc ccagagtcca gtggcagaat cgtctcttta cagactgcat ctaaccccat

1921 cgagtgctcc cagcgatctg ctcacgagct gcccatggtt gaaagacaag acacagacag

1981 ctgcctggtc tatggcggcc agcaaatgat cctcacgggg cagaacttta catccgagtc

2041 caaagttgtg tttactgaga agaccacaga tggacagcaa atttgggaga tggaagccac

2101 ggtggataag gacaagagcc agcccaacat gctttttgtt gagatccctg aatatcggaa

2161 caagcatatc cgcacacctg taaaagtgaa cttctacgtc atcaatggga agagaaaacg

2221 aagtcagcct cagcacttta cctaccaccc agtcccagcc atcaagacgg agcccacgga

2281 tgaatatgac cccactctga tctgcagccc cacccatgga ggcctgggga gccagcctta

2341 ctacccccag cacccgatgg tggccgagtc cccctcctgc ctcgtggcca ccatggctcc

2401 ctgccagcag ttccgcacgg ggctctcatc ccctgacgcc cgctaccagc aacagaaccc

2461 agcggccgta ctctaccagc ggagcaagag cctgagcccc agcctgctgg gctatcagca

2521 gccggccctc atggccgccc cgctgtccct tgcggacgct caccgctctg tgctggtgca

2581 cgccggctcc cagggccaga gctcagccct gctccacccc tctccgacca accagcaggc

2641 ctcgcctgtg atccactact cacccaccaa ccagcagctg cgctgcggaa gccaccagga

2701 gttccagcac atcatgtact gcgagaattt cgcaccaggc accaccagac ctggcccgcc

2761 cccggtcagt caaggtcaga ggctgagccc gggttcctac cccacagtca ttcagcagca

2821 gaatgccacg agccaaagag ccgccaaaaa cggacccccg gtcagtgacc aaaaggaagt

2881 attacctgcg ggggtgacca ttaaacagga gcagaacttg gaccagacct acttggatga

2941 tgttaatgaa attatcagga aggagttttc aggacctcct gccagaaatc agacgtaa

1 gctgcagcac cctgggccac gccgatgact actgcaaact gtggcgccca cgacgagctc

61 gacttcaaac tcgtctttgg cgaggacggg gcgccggcgc cgccgccccc gggctcgcgg

121 cctgcagatc ttgagccaga tgattgtgca tccatttaca tctttaatgt agatccacct

181 ccatctactt taaccacacc actttgctta ccacatcatg gattaccgtc tcactcttct

241 gttttgtcac catcgtttca gctccaaagt cacaaaaact atgaaggaac ttgtgagatt

301 cctgaatcta aatatagccc attaggtggt cccaaaccct ttgagtgccc aagtattcaa

361 attacatcta tctctcctaa ctgtcatcaa gaattagatg cacatgaaga tgacctacag

421 ataaatgacc cagaacggga atttttggaa aggccttcta gagatcatct ctatcttcct

481 cttgagccat cctaccggga gtcttctctt agtcctagtc ctgccagcag catctcttct

541 aggagttggt tctctgatgc atcttcttgt gaatcgcttt cacatattta tgatgatgtg

601 gactcagagt tgaatgaag.c tgcagcccga tttacccttg gatcccctct gacttctcct

661 ggtggctctc cagggggctg ccctggagaa gaaacttggc atcaacagta tggacttgga

721 cactcattat cacccaggca atctccttgc cactctccta gatccagtgt cactgatgag

781 aattggctga gccccaggcc agcctcagga ccctcatcaa ggcccacatc cccctgtggg

841 aaacggaggc actccagtgc tgaagtttgt tatgctgggt ccctttcacc ccatcactca

901 cctgttcctt cacctggtca ctcccccagg ggaagtgtga cagaagatac gtggctcaat

961 gcttctgtcc atggtgggtc aggccttggc cctgcagttt ttccatttca gtactgtgta

1021 gagactgaca tccctctcaa aacaaggaaa acttctgaag atcaagctgc catactacca

1081 ggaaaattag agctgtgttc agatgaccaa gggagtttat caccagcccg ggagacttca

1141 atagatgatg gccttggatc tcagtatcct ttaaagaaag attcatgtgg tgatcagttt

1201 ctttcagttc cttcaccctt tacctggagc aaaccaaagc ctggccacac ccctatattt

1261 cgcacatctt cattacctcc actagactgg cctttaccag ctcattttgg acaatgtgaa

1321 ctgaaaatag aagtgcaacc taaaactcat catcgagccc attatgaaac tgaaggtagc

1381 cgaggggcag taaaagcatc tactggggga catcctgttg tgaagctcct gggctataac

1441 gaaaagccaa taaatctaca aatgtttatt gggacagcag atgatcgata tttacgacct

1501 catgcatttt accaggtgca tcgaatcact gggaagacag tcgctactgc aagccaagag EPI-109 1028

1561 ataataattg ccagtacaaa agttctggaa attccacttc ttcctgaaaa taatatgtca 1621 gccagtattg attgtgcagg tattttgaaa ctccgcaatt cagatataga acttcgaaaa 1681 ggagaaactg atattggcag aaagaatact agagtacgac ttgtgtttcg tgtacacatc 1741 ccacagccca gtggaaaagt cctttctctg cagatagcct ctatacccgt tgagtgctcc 1801 cagcggtctg ctcaagaact tcctcatatt gagaagtaca gtatcaacag ttgttctgta 1861 aatggaggtc atgaaatggt tgtgactgga tctaattttc ttccagaatc caaaatcatt 1921 tttcttgaaa aaggacaaga tggacgacct cagtgggagg tagaagggaa gataatcagg 1981 gaaaaatgtc aaggggctca cattgtcctt gaagttcctc catatcataa cccagcagtt 2041 acagctgcag tgcaggtgca cttttatctt tgcaatggca agaggaaaaa aagccagtct 2101 caacgtttta cttatacacc agttttgctg aagcaagaac acagagaaga gattgatttg 2161 tcttcagttc catctttgcc tgtgcctcat cctgctcaga cccagaggcc ttcctctgat 2221 tcagggtgtt cacatgacag tgtactgtca ggacagagaa gtttgatttg ctccatccca 2281 caaacatatg catccatggt gacctcatcc catctgccac agttgcagtg tagagatgag 2341 agtgttagta aagaacagca tatgattcct tctccaattg tacaccagcc ttttcaagtc 2401 acaccaacac ctcctgtggg gtcttcctat cagcctatgc aaactaatgt tgtgtacaat 2461 ggaccaactt gtcttcctat taatgctgcc tctagtcaag aatttgattc agtttggttt 2521 cagcaggatg caactctttc tggtttagtg aatcttggct gtcaaccact gtcatccata 2581 ccatttcatt cttcaaattc aggctcaaca ggacatctct tagcccatac acctcattct 2641 gtgcataccc tgcctcatct gcaatcaatg ggatatcatt gttcaaatac aggacaaaga 2701 tctctttctt ctccagtggg tgaccagatt acaggtcagc cttcgtctca gttacaacct 2761 attacatatg gtccttcaca ttcagggtct gttacaacag cttccccagc agcttctcat 2821 cccttgggta gttcaccgct ttctgggcca ccatctcctc agtttcagcc tatgccttac 2881 caatctccta gctcaggaac tggctcatca ccgtctccag ccaccagaat gcattctgga 2941 cagcactcaa ctcaagcaca aagtacgggc caggggggtc tttctgcacc ttcatcctta 3001 atatgtcaca gtttgtgtga tccagcgtca tttccacctg atggggcaac tgtgagcatt 3061 aaacctgaac cagaagatcg agagcctaac tttgcaacca ttggtctgca ggacatcact 3121 ttagatgatg accaatttat atctgacttg gaacaccagc catcaggttc agcagagaaa 3181 tggcctaacc acagtgtgct ctcatgtcca gctcctttct ggagaatcta gaggtgaacg 3241 agataattgg gagagacatg tcccagattt ctgtttccca aggagcaggg gtgagcaggc 3301 aggctcccct cccgagtcct gagtccctgg atttaggaag atctgatggg ctctaacagt 3361 gcttactgca gccttgtgtc caccaccaac ttctcagcat gtttctctcc ttggaccttg 3421 ggtttccaac tcttcaacct tcaggtctgg ggccaggagt gggacccacc atttgtgggg 3481 aaagtagcat tcctccacct caggccttgg gtagatttgg caaaagaaca ggagcagcat 3541 aggctgtttg agctttgggg aaatgaactt tgctttttat atttaactag gatactttta 3601 aatgatgggt gctttgagtg tgaatccagc aggctctctt gtttccgagg tgctgctttt 3661 gcaggtgacc tggttactta actaggagtg gtgatttgta ctgctttatg gtcatttgaa 3721 gggcccttta gtttttatga taatttttaa aataggaact tttgataaga ccttctagaa 3781 gcaa

1 gctgcagcac cctgggccac gccgatgact actgcaaact gtggcgccca cgacgagctc

61 gacttcaaac tcgtctttgg cgaggacggg gcgccggcgc cgccgccccc gggctcgcgg

121 cctgcagatc ttgagccaga tgattgtgca tccatttaca tctttaatgt agatccacct

181 ccatctactt taaccacacc actttgctta ccacatcatg gattaccgtc tcactcttct

241 gttttgtcac catcgtttca gctccaaagt cacaaaaact atgaaggaac ttgtgagatt

301 cctgaatcta aatatagccc attaggtggt cccaaaccct ttgagtgccc aagtattcaa

361 attacatcta tctctcctaa ctgtcatcaa gaattagatg cacatgaaga tgacctacag

421 ataaatgacc cagaacggga atttttggaa aggccttcta gagatcatct ctatcttcct

481 cttgagccat cctaccggga gtcttctctt agtcctagtc ctgccagcag catctcttct

541 aggagttggt tctctgatgc atcttcttgt gaatcgcttt cacatattta tgatgatgtg

601 gactcagagt tgaatgaagc tgcagcccga tttacccttg gatcccctct gacttctcct

661 ggtggctctc cagggggctg ccctggagaa gaaacttggc atcaacagta tggacttgga

721 cactcattat cacccaggca atctccttgc cactctccta gatccagtgt cactgatgag

781 aattggctga gccccaggcc agcctcagga ccctcatcaa ggcccacatc cccctgtggg

841 aaacggaggc actccagtgc tgaagtttgt tatgctgggt ccctttcacc ccatcactca

901 cctgttcctt cacctggtca ctcccccagg ggaagtgtga cagaagatac gtggctcaat

961 gcttctgtcc atggtgggtc aggccttggc cctgcagttt ttccatttca gtactgtgta

1021 gagactgaca tccctctcaa aacaaggaaa acttctgaag atcaagctgc catactacca

1081 ggaaaattag agctgtgttc agatgaccaa gggagtttat caccagcccg ggagacttca

1141 atagatgatg gccttggatc tcagtatcct ttaaagaaag attcatgtgg tgatcagttt

1201 ctttcagttc cttcaccctt tacctggagc aaaccaaagc ctggccacac ccctatattt

1261 cgcacatctt cattacctcc actagactgg cctttaccag ctcattttgg acaatgtgaa

1321 ctgaaaatag aagtgcaacc taaaactcat catcgagccc attatgaaac tgaaggtagc

1381 cgaggggcag taaaagcatc tactggggga catcctgttg tgaagctcct gggctataac

1441 gaaaagccaa taaatctaca aatgtttatt gggacagcag atgatcgata tttacgacct

1501 catgcatttt accaggtgca tcgaatcact gggaagacag tcgctactgc aagccaagag

1561 ataataattg ccagtacaaa agttctggaa attccacttc ttcctgaaaa taatatgtca

1621 gccagtattg attgtgcagg tattttgaaa ctccgcaatt cagatataga acttcgaaaa

1681 ggagaaactg atattggcag aaagaatact agagtacgac ttgtgtttcg tgtacacatc

1741 ccacagccca gtggaaaagt cctttctctg cagatagcct ctatacccgt tgagtgctcc EPI-109 1029

1801 cagcggtctg ctcaagaact tcctcatatt gagaagtaca gtatcaacag ttgttctgta

1861 aatggaggtc atgaaatggt tgtgactgga tctaattttc ttccagaatc caaaatcatt

1921 tttcttgaaa aaggacaaga tggacgacct cagtgggagg tagaagggaa gataatcagg

1981 gaaaaatgtc aaggggctca cattgtcctt gaagttcctc catatcataa cccagcagtt

2041 acagctgcag tgcaggtgca cttttatctt tgcaatggca agaggaaaaa aagccagtct

2101 caacgtttta cttatacacc agttttgctg aagcaagaac acagagaaga gattgatttg

2161 tcttcagttc catctttgcc tgtgcctcat cctgctcaga cccagaggcc ttcctctgat

2221 tcagggtgtt cacatgacag tgtactgtca ggacagagaa gtttgatttg ctccatccca

2281 caaacatatg catccatggt gacctcatcc catctgccac agttgcagtg tagagatgag

2341 agtgttagta aagaacagca tatgattcct tctccaattg tacaccagcc ttttcaagtc

2401 acaccaacac ctcctgtggg gtcttcctat cagcctatgc aaactaatgt tgtgtacaat

2461 ggaccaactt gtcttcctat taatgctgcc tctagtcaag aatttgattc agtttggttt

2521 cagcaggatg caactctttc tggtttagtg aatcttggct gtcaaccact gtcatccata

2581 ccatttcatt cttcaaattc aggctcaaca ggacatctct tagcccatac acctcattct

2641 gtgcataccc tgcctcatct gcaatcaatg ggatatcatt gttcaaatac aggacaaaga

2701 tctctttctt ctccagtggg tgaccagatt acaggtcagc cttcgtctca gttacaacct

2761 attacatatg gtccttcaca ttcagggtct gttacaacag cttccccagc agcttctcat

2821 cccttgggta gttcaccgct ttctgggcca ccatctcctc agtttcagcc tatgccttac

2881 caatctccta gctcaggaac tggctcatca ccgtctccag ccaccagaat gcattctgga

2941 cagcactcaa ctcaagcaca aagtacgggc caggggggtc tttctgcacc ttcatcctta

3001 atatgtcaca gtttgtgtga tccagcgtca tttccacctg atggggcaac tgtgagcatt

3061 aaacctgaac cagaagatcg agagcctaac tttgcaacca ttggtctgca ggacatcact

3121 ttagatgatg atttgtttac cagtaataat tttgacttgc ttcagttgag acctacgttt

3181 tggccagtcc cagcaggaag atatctgagg aatctagagt gaacgagata attgggagag

3241 acatgtccca gatttctgtt tcccaaggag caggggtgag caggcaggct cccctcccga

3301 gtcctgagtc cctggattta ggaagatctg atgggctcta acagtgctta ctgcagcctt

3361 gtgtccacca ccaacttctc agcatgtttc tctccttgga ccttgggttt ccaactcttc

3421 aaccttcagg tctggggcca ggagtgggac ccaccatttg tggggaaagt agcattcctc

3481 cacctcaggc cttgggtaga tttggcaaaa gaacaggagc agcataggct gtttgagctt

3541 tggggaaatg aactttgctt tttatattta actaggatac ttttaaatga tgggtgcttt

3601 gagtgtgaat ccagcaggct ctcttgtttc cgaggtgctg cttttgcagg tgacctggtt

3661 acttaactag gagtggtgat ttgtactgct ttatggtcat ttgaagggcc ctttagtttt

3721 tatgataatt tttaaaatag gaacttttga taagaccttc tagaagcaa

1 gctgcagcac cctgggccac gccgatgact actgcaaact gtggcgccca cgacgagctc

61 gacttcaaac tcgtctttgg cgaggacggg gcgccggcgc cgccgccccc gggctcgcgg

121 cctgcagatc ttgagccaga tgattgtgca tccatttaca tctttaatgt agatccacct

181 ccatctactt taaccacacc actttgctta ccacatcatg gattaccgtc tcactcttct

241 gttttgtcac catcgtttca gctccaaagt cacaaaaact atgaaggaac ttgtgagatt

301 cctgaatcta aatatagccc attaggtggt cccaaaccct ttgagtgccc aagtattcaa

361 attacatcta tctctcctaa ctgtcatcaa gaattagatg cacatgaaga tgacctacag

421 ataaatgacc cagaacggga atttttggaa aggccttcta gagatcatct ctatcttcct

481 cttgagccat cctaccggga gtcttctctt agtcctagtc ctgccagcag catctcttct

541 aggagttggt tctctgatgc atcttcttgt gaatcgcttt cacatattta tgatgatgtg

601 gactcagagt tgaatgaagc tgcagcccga tttacccttg gatcccctct gacttctcct

661 ggtggctctc cagggggctg ccctggagaa gaaacttggc atcaacagta tggacttgga

721 cactcattat cacccaggca atctccttgc cactctccta gatccagtgt cactgatgag

781 aattggctga gccccaggcc agcctcagga ccctcatcaa ggcccacatc cccctgtggg

841 aaacggaggc actccagtgc tgaagtttgt tatgctgggt ccctttcacc ccatcactca

901 cctgttcctt cacctggtca ctcccccagg ggaagtgtga cagaagatac gtggctcaat

961 gcttctgtcc atggtgggtc aggccttggc cctgcagttt ttccatttca gtactgtgta

1021 gagactgaca tccctctcaa aacaaggaaa acttctgaag atcaagctgc catactacca

1081 ggaaaattag agctgtgttc agatgaccaa gggagtttat caccagcccg ggagacttca

1141 atagatgatg gccttggatc tcagtatcct ttaaagaaag attcatgtgg tgatcagttt

1201 ctttcagttc cttcaccctt tacctggagc aaaccaaagc ctggccacac ccctatattt

1261 cgcacatctt cattacctcc actagactgg cctttaccag ctcattttgg acaatgtgaa

1321 ctgaaaatag aagtgcaacc taaaactcat catcgagccc attatgaaac tgaaggtagc

1381 cgaggggcag taaaagcatc tactggggga catcctgttg tgaagctcct gggctataac

1441 gaaaagccaa taaatctaca aatgtttatt gggacagcag atgatcgata tttacgacct

1501 catgcatttt accaggtgca tcgaatcact gggaagacag tcgctactgc aagccaagag

1561 ataataattg ccagtacaaa agttctggaa attccacttc ttcctgaaaa taatatgtca

1621 gccagtattg attgtgcagg tattttgaaa ctccgcaatt cagatataga acttcgaaaa

1681 ggagaaactg atattggcag aaagaatact agagtacgac ttgtgtttcg tgtacacatc

1741 ccacagccca gtggaaaagt cctttctctg cagatagcct ctatacccgt tgagtgctcc

1801 cagcggtctg ctcaagaact tcctcatatt gagaagtaca gtatcaacag ttgttctgta

1861 aatggaggtc atgaaatggt tgtgactgga tctaattttc ttccagaatc caaaatcatt

1921 tttcttgaaa aaggacaaga tggacgacct cagtgggagg tagaagggaa gataatcagg

1981 gaaaaatgtc aaggggctca cattgtcctt gaagttcctc catatcataa cccagcagtt

2041 acagctgcag tgcaggtgca cttttatctt tgcaatggca agaggaaaaa aagccagtct EPI-109 1030

2101 caacgtttta cttatacacc agttttgctg aagcaagaac acagagaaga gattgatttg 2161 tcttcagttc catctttgcc tgtgcctcat cctgctcaga cccagaggcc ttcctctgat 2221 tcagggtgtt cacatgacag tgtactgtca ggacagagaa gtttgatttg ctccatccca 2281 caaacatatg catccatggt gacctcatcc catctgccac agttgcagtg tagagatgag 2341 agtgttagta aagaacagca tatgattcct tctccaattg tacaccagcc ttttcaagtc 2401 acaccaacac ctcctgtggg gtcttcctat cagcctatgc aaactaatgt tgtgtacaat 2461 ggaccaactt gtcttcctat taatgctgcc tctagtcaag aatttgattc agtttggttt 2521 cagcaggatg caactctttc tggtttagtg aatcttggct gtcaaccact gtcatccata 2581 ccatttcatt cttcaaattc aggctcaaca ggacatctct tagcccatac acctcattct 2641 gtgcataccc tgcctcatct gcaatcaatg ggatatcatt gttcaaatac aggacaaaga 2701 tctctttctt ctccagtggg tgaccagatt acaggtcagc cttcgtctca gttacaacct 2761 attacatatg gtccttcaca ttcagggtct gttacaacag cttccccagc agcttctcat 2821 cccttgggta gttcaccgct ttctgggcca ccatctcctc agtttcagcc tatgccttac 2881 caatctccta gctcaggaac tggctcatca ccgtctccag ccaccagaat gcattctgga 2941 cagcactcaa ctcaagcaca aagtacgggc caggggggtc tttctgcacc ttcatcctta 3001 atatgtcaca gtttgtgtga tccagcgtca tttccacctg atggggcaac tgtgagcatt 3061 aaacctgaac cagaagatcg agagcctaac tttgcaacca ttggtctgca ggacatcact 3121 ttagatgatg gtaagttcat ctctgatatg ttcttgaagt agtgaagatt cagggacttt 3181 attctcccaa gtgtcatgaa aaagtttcta tggattgctt attggcatat ggttgggctt 3241 ttaaataagt tgttattaga aatatatgtt aatatataac tttgccaggt accacggctc 3301 acgcctgtat cccagcactt tggaaggctg aggcgggtgg atcacaaggt caggagttca 3361 agaccagcct ggccaacatg gtgtaacgct gtctctacta aaaatacaaa aaattagcca 3421 ggcatggtgg tgtgtgacta taatcccagc tactcgggag gctgagacag gagaatcact 3481 tgaacccggg aggtggcagt tgcagggagc taagatcgcg ccattgcact ccagcctggg 3541 cggcagagca agactccgtc tcgggaaaaa aaaaaaaaaa aaa

1 gaattccggg ccgggagaac cgaacccctg gcggccgcga ccccggctcc cgccccggcc

61 ccggcccgac ccgccatgac ggggctggag gaccaggagt tcgacttcga gttcctcttc

121 gagtttaacc agcgcgacga gggcgccgcc gcggccgccc cagaacacta tggctatgca

181 tcctccaacg tcagccccgc cctgccgctc cccacggcgc actccaccct gccggccccg

241 tgccacaacc ttcagacctc cacaccgggc atcatcccgc cggcggatca cccctcgggg

301 tacggagcag ctttggacgg tgggcctgcg ggctacttcc tctcctccgg ccacaccagg

361 cctgatgggg cccctgccct ggagagtcct cgcatcgaga taacctcgtg cttgggcctg

421 taccacaaca ataaccagtt tttccacgat gtggaggtgg aagacgtcct ccctagctcc

481 aaacggtccc cctccacggc cacgctgagt ctgcccagcc tggaggccta cagagacccc

541 tcgtgcctga gcccggccag cagcctgtcc tcccggagct gcaactcaga ggcctcctcc

601 tacgagtcca actactcgta cccgtacgcg tccccccaga cgtcgccatg gcagtctccc

661 tgcgtgtctc ccaagaccac ggaccccgag gagggctttc cccgcgggct gggggcctgc

721 acactgctga gttccccgcg gcactccccc tccacctcgc cccgcgccag cgtcactgag

781 gagagctggc tgggtgcccg ctcctccaga cccgcgtccc cttgcaacaa gaggaagtac

841 agcctcaacg gccggcagcc gccctactca ccccaccact cgcccacgcc atccccgcac

901 ggctccccgc gggtcagcgt gaccgacgac tcgtggttgg gcaacaccac ccagtacacc

961 agctcggcca tcgtggccgc catcaacgcg ctgaccaccg acagcagcct ggacctggga

1021 gatggcgtcc ctgtcaagtc ccgcaagacc accctggagc agccgccctc agtggcgctc

1081 aaggtggagc ccgtcgggga ggacctgggc agccccccgc ccccggccga cttcgcgccc

1141 gaagactact cctctttcca gcacatcagg aagggcggct tctgcgacca gtacctggcg

1201 gtgccgcagc acccctacca gtgggcgaag cccaagcccc tgtcccctac gtcctacatg

1261 agcccgaccc tgcccgccct ggactggcag ctgccgtccc actcaggccc gtatgagctt

1321 cggattgagg tgcagcccaa gtcccaccac cgagcccact acgagacgga gggcagccgg

1381 ggggccgtga aggcgtcggc cggaggacac cccatcgtgc agctgcatgg ctacttggag

1441 aatgagccgc tgatgctgca gcttttcatt gggacggcgg acgaccgcct gctgcgcccg

1501 cacgccttct accaggtgca ccgcatcaca gggaagaccg tgtccaccac cagccacgag

1561 gccatcctct ccaacaccaa agtcctggag atcccactcc tgccggagaa cagcatgcga

1621 gccgtcattg actgtgccgg aatcctgaaa ctcagaaact ccgacattga acttcggaaa

1681 ggagagacgg acatcgggag gaagaacaca cgggtacggc tggtgttccg cgttcacgtc

1741 ccgcaaccca gcggccgcac gctgtccctg caggtggcct ccaaccccat cgaatgctcc

1801 cagcgctcag ctcaggagct gcctctggtg gagaagcaga gcacggacag ctatccggtc

1861 gtgggcggga agaagatggt cctgtctggc cacaacttcc tgcaggactc caaggtcatt

1921 ttcgtggaga aagccccaga tggccaccat gtctgggaga tggaagcgaa aactgaccgg

1981 gacctgtgca agccgaattc tctggtggtt gagatcccgc cgtttcggaa tcagaggata

2041 accagccccg ttcacgtcag tttctacgtc tgcaacggga agagaaagcg aagccagtac

2101 cagcgtttca cctaccttcc cgccaacgtt ccaattataa aaacagaacc cactgatgat

2161 tatgagcctg ctccaacctg tggaccggtg agccaggggt taagtcctct cccaagacca

2221 tactacagcc agcagctcgc gatgccaccc gaccccagct cctgcctcgt ggccggcttc

2281 ccgccctgtc cgcagagaag caccctgatg ccagcggccc ctggcgtgag ccccaagctc

2341 cacgaccttt ctcccgctgc ctacaccaag ggcgttgcca gcccgggcca ctgtcacctc

2401 ggactcccgc agccggccgg agaggccccc gccgtccagg acgtgcccag gccagtggcc

2461 acgcaccccg gctcgcccgg gcagccaccc ccggccctgc tgccacagca gtaaatgaaa

2521 taatacgaaa tgacctctcc agcacgagca cccactccta gttgccacat tggagcactc EPI-109 1031

2581 agttcagcag gggtatgctg acttcagcag acaaagactt ttgaataaat aaactgaact 2641 cacacctggt accactcaga acctccaact gactgaatgc caggagctga acattaatat 2701 gtgcaaagat tggctctcca acaagaagga aagcagggag gaagggagac cactgtgtcg 2761 cctggaggag aagtcatctc atgacaacag aagggaggtg gccgggctga gcacggagac 2821 ccaccgtgca ggggcctttc atgggaacgg cccacacgca gtttgacccc acgcccagcc 2881 cttctggcac ccctggggtt caatactgga agtgccttat ttaaccagac catca

(2) INFORMATION FOR SEQ ID NO:2753: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2753

1 gaattcccaa ggcgcccccg accgcctgct acgcgggggc cgcgccggcg ccctcgcagg 61 tcaagagcaa ggccaagaag accgtggaca agcacagcga cgagtacaag atccggcgcg 121 agcgcaacaa catcgccgtg cgcaagagcc gcgacaaggc caagatgcgc aacctggaga 181 cgcagcacaa ggtcctggag ctcacggccg agaacgagcg gctgcagaag aaggtggagc 241 agctgtcgcg cgagggaatt c

(2) INFORMATION FOR SEQ ID NO: 2754: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2754

1 gtccttcgcg tcccggcggc gcggcggagg ggccggcgtg acgcagcggt tgctacgggc

61 cgcccttata aataaccggg ctcaggagaa actttagcga gtcagagccg cgcacgggac

121 tgggaagggg acccacccga gggtccagcc accagccccc tcactaatag cggccacccc

181 ggcagcggcg gcagcagcag cagcgacgca gcggcgacag ctcagagcag ggaggccgcg

241 cacctgcggg ccggccggag cgggcagccc caggccccct ccccgggcac ccgcgttcat

301 gcaacgcctg gtggcctggg acccagcatg tctccccctg ccgccgccgc cgcctgcctt

361 taaatccatg gaagtggcca acttctacta cgaggcggac tgcttggctg ctgcgtacgg

421 cggcaaggcg gcccccgcgg cgccccccgc ggccagaccc gggccgcgcc cccccgccgg

481 cgagctgggc agcatcggcg accacgagcg cgccatcgac ttcagcccgt acctggagcc

541 gctgggcgcg ccgcaggccc cggcgcccgc cacggccacg gacaccttcg aggcggctcc

601 gcccgcgccc gcccccgcgc ccgcctcctc cgggcagcac cacgacttcc tctccgacct

661 cttctccgac gactacgggg gcaagaactg caagaagccg gccgagtacg gctacgtgag

721 cctggggcgc ctgggggctg ccaagggcgc gctgcacccc ggctgcttcg cgcccctgca

781 cccaccgccc ccgccgccgc cgccgcccgc cgagctcaag gcggagccgg gcttcgagcc

841 cgcggactgc aagcggaagg aggaggccgg ggcgccgggc ggcggcgcag gcatggcggc

901 gggcttcccg tacgcgctgc gcgcttacct cggctaccag gcggtgccga gcggcagcag

961 cgggagcctc tccacgtcct cctcgtccag cccgcccggc acgccgagcc ccgctgacgc

1021 caaggccccc ccgaccgcct gctacgcggg ggccgggccg gcgccctcgc aggtcaagag

1081 caaggccaag aagaccgtgg acaagcacag cgacgagtac aagatccggc gcgagcgcaa

1141 caacatcgcc gtgcgcaaga gccgcgacaa ggccaagatg cgcaacctgg agacgcagca

1201 caaggtcctg gagctcacgg ccgagaacga gcggctgcag aagaaggtgg agcagctgtc

1261 gcgcgagctc agcaccctgc ggaacttgtt caagcagctg cccgagcccc tgctcgcctc

1321 ctccggccac tgctagcgcg gcccccgcgg cgtccccctg gggccggccg gggctgagac

1381 tccggggagc gcccgcgccc gcgccctcgc ccccnccccc nnnnccgcaa aactttggca

1441 ctggggcact tggcagcngg ggagcccgtc ggtaatttta atattttatt atatatatat

1501 atctatattt tgccaaccaa ccgtacatgc agatggctcc cgcccgtggt gtataaagaa

1561 gaaatgtcta tgtgtacaga tgaatgataa actctctgct ctccctctgc ccctctccag

1621 gcccggcggg cggggccggt ttcgaagttg atgcaatcgg tttaaacatg gctgaacgcg

1681 tgtgtacacg ggactgacgc aacccacgtg taactgtcag ccgggccctg agtaatcgct

1741 taaagatgtt ctagggcttg ttgctgttga tgttttgttt tgttttgttt tttggtcttt

1801 ttttgtatta taaaaaataa tctatttcta tgagaaaaga ggcgtctgta tattttggga

1861 atcttttccg tttcaagca^'a ttaagaacac ttttaataaa cttttttttg

(2) INFORMATION FOR SEQ ID NO: 2755: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2755

1 gaattcccaa ggcgcccccg accgcctgct acgcgggggc cgcgccggcg ccctcgcagg 61 tcaagagcaa ggccaagaag accgtggaca agcacagcga cgagtacaag atccggcgcg 121 agcgcaacaa catcgccgtg cgcaagagcc gcgacaaggc caagatgcgc aacctggaga EPI-109 1032

181 cgcagcacaa ggtcctggag ctcacggccg agaacgagcg gctgcagaag aaggtggagc 241 agctgtcgcg cgagggaatt c

1 gtccttcgcg tcccggcggc gcggcggagg ggccggcgtg acgcagcggt tgctacgggc

61 cgcccttata aataaccggg ctcaggagaa actttagcga gtcagagccg cgcacgggac

121 tgggaagggg acccacccga gggtccagcc accagccccc tcactaatag cggccacccc

181 ggcagcggcg gcagcagcag cagcgacgca gcggcgacag ctcagagcag ggaggccgcg

241 cacctgcggg ccggccggag cgggcagccc caggccccct ccccgggcac ccgcgttcat

301 gcaacgcctg gtggcctggg acccagcatg tctccccctg ccgccgccgc cgcctgcctt

361 taaatccatg gaagtggcca acttctacta cgaggcggac tgcttggctg ctgcgtacgg

421 cggcaaggcg gcccccgcgg cgccccccgc ggccagaccc gggccgcgcc cccccgccgg

481 cgagctgggc agcatcggcg accacgagcg cgccatcgac ttcagcccgt acctggagcc

541 gctgggcgcg ccgcaggccc cggcgcccgc cacggccacg gacaccttcg aggcggctcc

601 gcccgcgccc gcccccgcgc ccgcctcctc cgggcagcac cacgacttcc tctccgacct

661 cttctccgac gactacgggg gcaagaactg caagaagccg gccgagtacg gctacgtgag

721 cctggggcgc ctgggggctg ccaagggcgc gctgcacccc ggctgcttcg cgcccctgca

781 cccaccgccc ccgccgccgc cgccgcccgc cgagctcaag gcggagccgg gcttcgagcc

841 cgcggactgc aagcggaagg aggaggccgg ggcgccgggc ggcggcgcag gcatggcggc

901 gggcttcccg tacgcgctgc gcgcttacct cggctaccag gcggtgccga gcggcagcag

961 cgggagcctc tccacgtcct cctcgtccag cccgcccggc acgccgagcc ccgctgacgc

1021 caaggccccc ccgaccgcct gctacgcggg ggccgggccg gcgccctcgc aggtcaagag

1081 caaggccaag aagaccgtgg acaagcacag cgacgagtac aagatccggc gcgagcgcaa

1141 caacatcgcc gtgcgcaaga gccgcgacaa ggccaagatg cgcaacctgg agacgcagca

1201 caaggtcctg gagctcacgg ccgagaacga gcggctgcag aagaaggtgg agcagctgtc

1261 gcgcgagctc agcaccctgc ggaacttgtt caagcagctg cccgagcccc tgctcgcctc

1321 ctccggccac tgctagcgcg gcccccgcgg cgtccccctg gggccggccg gggctgagac

1381 tccggggagc gcccgcgccc gcgccctcgc ccccnccccc nnnnccgcaa aactttggca

1441 ctggggcact tggcagcngg ggagcccgtc ggtaatttta atattttatt atatatatat

1501 atctatattt tgccaaccaa ccgtacatgc agatggctcc cgcccgtggt gtataaagaa

1561 gaaatgtcta tgtgtacaga tgaatgataa actctctgct ctccctctgc ccctctccag

1621 gcccggcggg cggggccggt ttcgaagttg atgcaatcgg tttaaacatg gctgaacgcg

1681 tgtgtacacg ggactgacgc aacccacgtg taactgtcag ccgggccctg agtaatcgct

1741 taaagatgtt ctagggcttg ttgctgttga tgttttgttt tgttttgttt tttggtcttt

1801 ttttgtatta taaaaaataa tctatttcta tgagaaaaga ggcgtctgta tattttggga

1861 atcttttccg tttcaagcaa ttaagaacac ttttaataaa cttttttttg

(2) INFORMATION FOR SEQ ID NO:2756: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2756

1 gaccagagca atttctgctt ttcacagggc gggtttctca acggtgactt gtgggcagtg

61 ccttctgctg agcgagtcat ggcccgaagg cagaactaac tgtgcctgca gtcttcactc

121 tcaggatgca gccgaggtgg gcccaagggg ccacgatgtg gcttggagtc ctgctgaccc

181 ttctgctctg ttcaagcctt gagggtcaag aaaactcttt cacaatcaac agtgttgaca

241 tgaagagcct gccggactgg acggtgcaaa atgggaagaa cctgaccctg cagtgcttcg

301 cggatgtcag caccacctct cacgtcaagc ctcagcacca gatgctgttc tataaggatg

361 acgtgctgtt ttacaacatc tcctccatga agagcacaga gagttatttt attcctgaag

421 tccggatcta tgactcaggg acatataaat gtactgtgat tgtgaacaac aaagagaaaa

481 ccactgcaga gtaccaggtg ttggtggaag gagtgcccag tcccagggtg acactggaca

541 agaaagaggc catccaaggt gggatcgtga gggtcaactg ttctgtccca gaggaaaagg

601 ccccaataca cttcacaatt gaaaaacttg aactaaatga aaaaatggtc aagctgaaaa

661 gagagaagaa ttctcgagac cagaattttg tgatactgga attccccgtt gaggaacagg

721 accgcgtttt atccttccga tgtcaagcta ggatcatttc tgggatccat atgcagacct

781 cagaatctac caagagtgaa ctggtcaccg tgacggaatc cttctctaca cccaagttcc

841 acatcagccc caccggaatg atcatggaag gagctcagct ccacattaag tgcaccattc

901 aagtgactca cctggcccag gagtttccag aaatcataat tcagaaggac aaggcgattg

961 tggcccacaa cagacatggc aacaaggctg tgtactcagt catggccatg gtggagcaca

1021 gtggcaacta cacgtgcaaa gtggagtcca gccgcatatc caaggtcagc agcatcgtgg

1081 tcaacataac agaactattt tccaagcccg aactggaatc ttccttcaca catctggacc

1141 aaggtgaaag actgaacctg tcctgctcca tcccaggagc acctccagcc aacttcacca

1201 tccagaagga agatacgatt gtgtcacaga ctcaagattt caccaagata gcctcaaagt

1261 cggacagtgg gacgtatatc tgcactgcag gtattgacaa agtggtcaag aaaagcaaca

1321 cagtccagat agtcgtatgt gaaatgctct cccagcccag gatttcttat gatgcccagt

1381 ttgaggtcat aaaaggacag accatcgaag tccgttgcga atcgatcagt ggaactttgc

1441 ctatttctta ccaactttta aaaacaagta aagttttgga gaatagtacc aagaactcaa

1501 atgatcctgc ggtattcaaa gacaacccca ctgaagacgt cgaataccag tgtgttgcag

1561 ataattgcca ttcccacgcc aaaatgttaa gtgaggttct gagggtgaag gtgatagccc EPI-109 1033

1621 cggtggatga ggtccagatt tctatcctgt caagtaaggt ggtggagtct ggagaggaca

1681 ttgtgctgca atgtgctgtg aatgaaggat ctggtcccat cacctataag ttttacagag

1741 aaaaagaggg caaacccttc tatcaaatga cctcaaatgc cacccaggca ttttggacca

1801 agcagaaggc taacaaggaa caggagggag agtattactg cacagccttc aacagagcca

1861 accacgcctc cagtgtcccc agaagcaaaa tactgacagt cagagtcatt cttgccccat

1921 ggaagaaagg acttattgca gtggttatca tcggagtgat cattgctctc ttgatcattg

1981 cggccaaatg ttattttctg aggaaagcca aggccaagca gatgccagtg gaaatgtcca

2041 ggccagcagt accacttctg aactccaaca acgagaaaat gtcagatccc aatatggaag

2101 ctaacagtca ttacggtcac aatgacgatg tcggaaacca tgcaatgaaa ccaataaatg

2161 ataataaaga gcctctgaac tcagacgtgc agtacacgga agttcaagtg tcctcagctg

2221 agtctcacaa agatctagga aagaaggaca cagagacagt gtacagtgaa gtccggaaag

2281 ctgtccctga tgccgtggaa agcagatact ctagaacgga aggctccctt gatggaactt

2341 agacagcaag gccagatgca catccctgga aggacatcca tgttccgaga agaacagatg

2401 atccctgtat ttcaagacct ctgtcc

(2) INFORMATION FOR SEQ ID NO:2757: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2757

1 gaattccggg agaagtgacc agagcaattt ctgcttttca cagggcgggt ttctcaacgg

61 tgacttgtgg gcagtgcctt ctgctgagcg agtcatggcc cgaaggcaga actaactgtg

121 cctgcagtct tcactctcag gatgcagccg aggtgggccc aaggggccac gatgtggctt

181 ggagtcctgc tgacccttct gctctgttca agccttgagg gtcaagaaaa ctctttcaca

241 atcaacagtg ttgacatgaa gagcctgccg gactggacgg tgcaaaatgg gaagaacctg

301 accctgcagt gcttcgcgga tgtcagcacc acctctcacg tcaagcctca gcaccagatg

361 ctgttctata aggatgacgt gctgttttac aacatctcct ccatgaagag cacagagagt

421 tattttattc ctgaagtccg gatctatgac tcagggacat ataaatgtac tgtgattgtg

481 aacaacaaag agaaaaccac tgcagagtac cagctgttgg tggaaggagt gcccagtccc

541 agggtgacac tggacaagaa agaggccatc caaggtggga tcgtgagggt caactgttct

601 gtcccagagg aaaaggcccc aatacacttc acaattgaaa aacttgaact aaatgaaaaa

661 atggtcaagc tgaaaagaga gaagaattct cgagaccaga attttgtgat actggaattc

721 cccgttgagg aacaggaccg cgttttatcc ttccgatgtc aagctaggat catttctggg

781 atccatatgc agacctcaga atctaccaag agtgaactgg tcaccgtgac ggaatccttc

841 tctacaccca agttccacat cagccccacc ggaatgatca tggaaggagc tcagctccac

901 attaagtgca ccattcaagt gactcacctg gcccaggagt ttccagaaat cataattcag

961 aaggacaagg cgattgtggc ccacaacaga catggcaaca aggctgtgta ctcagtcatg

1021 gccatggtgg agcacagtgg caactacacg tgcaaagtgg agtccagccg catatccaag

1081 gtcagcagca tcgtggtcaa cataacagaa ctattttcca agcccgaact ggaatcttcc

1141 ttcacacatc tggaccaagg tgaaagactg aacctgtcct gctccatccc aggagcacct

1201 ccagccaact tcaccatcca gaaggaagat acgattgtgt cacagactca agatttcacc

1261 aagatagcct caaagtcgga cagtgggacg tatatctgca ctgcaggtat tgacaaagtg

1321 gtcaagaaaa gcaacacagt ccagatagtc gtatgtgaaa tgctctccca gcccaggatt

1381 tcttatgatg cccagtttga ggtcataaaa ggacagacca tcgaagtccg ttgcgaatcg

1441 atcagtggaa ctttgcctat ttcttaccaa cttttaaaaa caagtaaagt tttggagaat

1501 agtaccaaga actcaaatga tcctgcggta ttcaaagaca accccactga agacgtcgaa

1561 taccagtgtg ttgcagataa ttgccattcc catgccaaaa tgttaagtga ggttctgagg

1621 gtgaaggtga tagccccggt ggatgaggtc cagatttcta tcctgtcaag taaggtggtg

1681 gagtctggag aggacattgt gctgcaatgt gctgtgaatg aaggatctgg tcccatcacc

1741 tataagtttt acagagaaaa agagggcaaa cccttctatc aaatgacctc aaatgccacc

1801 caggcatttt ggaccaagca gaaggctagc aaggaacagg agggagagta ttactgcaca

1861 gccttcaaca gagccaacca cgcctccagt gtccccagaa gcaaaatact gacagtcaga

1921 gtcattcttg ccccatggaa gaaaggactt attgcagtgg ttatcatcgg agtgatcatt

1981 gctctcttga tcattgcggc caaatgttat tttctgagga aagccaaggc caagcagatg

2041 ccagtggaaa tgtccaggcc agcagtacca cttctgaact ccaacaacga gaaaatgtca

2101 gatcccaata tggaagctaa cagtcattac ggtcacaatg acgatgtcag aaaccatgca

2161 atgaaaccaa taaatgataa taaagagcct ctgaactcag acgtgcagta cacggaagtt

2221 caagtgtcct cagctgagtc tcacaaagat ctaggaaaga aggacacaga gacagtgtac

2281 agtgaagtcc ggaaagctgt ccctgatgcc gtggaaagca gatactctag aacggaaggc

2341 tcccttgatg gaacttagac agcaaggcca gatgcacatc cctggaagga catccatgtt

2401 ccgagaagaa cagataatcc ctgtatttca agacctctgt gcacttattt atgaacctgc

2461 cctgctccca cagaacacag caattcctca ggctaagctg ccggttctta aatccatcct

2521 gctaagttaa tgttgggtag aaagagatac agagggg

(2) INFORMATION FOR SEQ ID NO: 2758:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: base pairs EPI-109 1034

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2758

1 cccgggttca agcgattctc ctgcctcagc ctcttgggta gctgggatta taggcgtgtg 61 ccaccgtgcc tggctaattt ttgtattttt attggagaca gggtttcacc atgttggcca

121 ggctggtctg aaactcctga cctcaggcaa tcctcctacc tcagcctctc aaagtgctgg

181 gattaccggc atgagccacg actcccggcc ccaaaggtca atcttaaagc tacaaggtat

241 cttttaaaag gagtaggaat aacgtatttt gaggcttaaa ggagtaggaa tagtgtattt

301 ttagatttga agccatcttc taaagggtac gatatttggt taacatgtca ctccttatcg 361 ccatggaaga agttaattct attctttttt tttttttttt gagatggagt ctcactctgt 421 tgcccaggct ggagtacaat ggtgtgatct cagctcactg caacctctgc ctcctgggtt

481 caagcaattc tcctgcctca gcctcctgag tagcagggat tacaggggtt ctccaccatg

541 cctgtctaat ttttgtattt ttttttttag tagaggtgga gtttcaccat gttggtcagg

601 ctggtctcaa acccctaacc tcatgatccg cccgccttgg cctcccaaag tgctgggatt

661 acaggcgtga gccaccatgc ccagccgtta attctattct tactgcttac tcccttattt

721 tgtatgttct tcttctatct tacatctttt gcttttgcta ttgcttaagc tagcctacgc

781 caagggtgct ctttgccccc tacttcctct gctattctcg cctcagttcc gctgcattcc

841 aagctcagcc tgccccagca gcaggtctct ttgacaaacc tgcaattttg gggaaaagtc

901 agccccaaga aaggcagggg gcccagactt atgctgtgtg gcaaaagccc tctttgatgg

961 gggaagggga ggactggaaa agcagagaga tctttctgga tgtcctggga gagcagccct

1021 ttgggtggtg ggtggaggct ggaggcaggg aggaatcccc tcacagtgcc atgagaaggg

1081 cccccaaacc caggcgagac agagggaggg tcaagaacgc caaggcaaat gtcacttgtg 1141 ccttgttttt tccctaaaga aactaaacaa agcggccgcg ttcggtggcc cctcaggaag

1201 gccggtcatt tcctgaggag atatcaggcc agcccaggcc ccattgttcc cggtttccag

1261 ccatggctgc cattacctga ccagcgccac agccggtctc tctgcaggcg ccgggagaag

1321 tgaccagagc aatttctgct tttcacaggg cgggtttctc aacggtgact tgtgggcagt

1381 gccttctgct gagcgagtca tggcccgaag gcagaactaa ctgtgcctgc agtcttcact

1441 ctcaggatgc agccgaggtg ggcccaaggg gccacgatgt ggcttggagt cctgctgacc

1501 cttctgctct gtgagtgttt actctgtttc cacatcactt taactccatg agcatcgaag

INFORMATION FOR SEQ ID NO: 2759: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2759

1 gaattccggg agaagtgacc agagcaattt ctgcttttca cagggcgggt ttctcaacgg

61 tgacttgtgg gcagtgcctt ctgctgagcg agtcatggcc cgaaggcaga actaactgtg

121 cctgcagtct tcactctcag gatgcagccg aggtgggccc aaggggccac gatgtggctt

181 ggagtcctgc tgacccttct gctctgttca agccttgagg gtcaagaaaa ctctttcaca

241 atcaacagtg ttgacatgaa gagcctgccg gactggacgg tgcaaaatgg gaagaacctg

301 accctgcagt gcttcgcgga tgtcagcacc acctctcacg tcaagcctca gcaccagatg

361 ctgttctata aggatgacgt gctgttttac aacatctcct ccatgaagag cacagagagt

421 tattttattc ctgaagtccg gatctatgac tcagggacat ataaatgtac tgtgattgtg

481 aacaacaaag agaaaaccac tgcagagtac cagctgttgg tggaaggagt gcccagtccc

541 agggtgacac tggacaagaa agaggccatc caaggtggga tcgtgagggt caactgttct

601 gtcccagagg aaaaggcccc aatacacttc acaattgaaa aacttgaact aaatgaaaaa

661 atggtcaagc tgaaaagaga gaagaattct cgagaccaga attttgtgat actggaattc

721 cccgttgagg aacaggaccg cgttttatcc ttccgatgtc aagctaggat catttctggg

781 atccatatgc agacctcaga atctaccaag agtgaactgg tcaccgtgac ggaatccttc

841 tctacaccca agttccacat cagccccacc ggaatgatca tggaaggagc tcagctccac

901 attaagtgca ccattcaagt gactcacctg gcccaggagt ttccagaaat cataattcag

961 aaggacaagg cgattgtggc ccacaacaga catggcaaca aggctgtgta ctcagtcatg

1021 gccatggtgg agcacagtgg caactacacg tgcaaagtgg agtccagccg catatccaag

1081 gtcagcagca tcgtggtcaa cataacagaa ctattttcca agcccgaact ggaatcttcc

1141 ttcacacatc tggaccaagg tgaaagactg aacctgtcct gctccatccc aggagcacct

1201 ccagccaact tcaccatcca gaaggaagat acgattgtgt cacagactca agatttcacc

1261 aagatagcct caaagtcgga cagtgggacg tatatctgca ctgcaggtat tgacaaagtg

1321 gtcaagaaaa gcaacacagt ccagatagtc gtatgtgaaa tgctctccca gcccaggatt

1381 tcttatgatg cccagtttga ggtcataaaa ggacagacca tcgaagtccg ttgcgaatcg

1441 atcagtggaa ctttgcctat ttcttaccaa cttttaaaaa caagtaaagt tttggagaat

1501 agtaccaaga actcaaatga tcctgcggta ttcaaagaca accccactga agacgtcgaa

1561 taccagtgtg ttgcagataa ttgccattcc catgccaaaa tgttaagtga ggttctgagg

1621 gtgaaggtga tagccccggt ggatgaggtc cagatttcta tcctgtcaag taaggtggtg

1681 gagtctggag aggacattgt gctgcaatgt gctgtgaatg aaggatctgg tcccatcacc

1741 tataagtttt acagagaaaa agagggcaaa cccttctatc aaatgacctc aaatgccacc

1801 caggcatttt ggaccaagca gaaggctagc aaggaacagg agggagagta ttactgcaca ;PI-109 1035

1861 gccttcaaca gagccaacca cgcctccagt gtccccagaa gcaaaatact gacagtcaga

1921 gtcattcttg ccccatggaa gaaaggactt attgcagtgg ttatcatcgg agtgatcatt

1981 gctctcttga tcattgcggc caaatgttat tttctgagga aagccaaggc caagcagatg

2041 ccagtggaaa tgtccaggcc agcagtacca cttctgaact ccaacaacga gaaaatgtca

2101 gatcccaata tggaagctaa cagtcattac ggtcacaatg acgatgtcag aaaccatgca

2161 atgaaaccaa taaatgataa taaagagcct ctgaactcag acgtgcagta cacggaagtt

2221 caagtgtcct cagctgagtc tcacaaagat ctaggaaaga aggacacaga gacagtgtac

2281 agtgaagtcc ggaaagctgt ccctgatgcc gtggaaagca gatactctag aacggaaggc

2341 tcccttgatg gaacttagac agcaaggcca gatgcacatc cctggaagga catccatgtt

2401 ccgagaagaa cagataatcc ctgtatttca agacctctgt gcacttattt atgaacctgc

2461 cctgctccca cagaacacag caattcctca ggctaagctg ccggttctta aatccatcct

2521 gctaagttaa tgttgggtag aaagagatac agagggg

(2) INFORMATION FOR SEQ ID NO: 2760 (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION SEQ ID NO: 2760

1 tcttttggtt ttgctattgc ttaagctagc ctacgccaag ggtgctcttt gccccctact

61 tcctctgcta ttctcgcctc agttccgctg cattccaagc tcagcctgcc ccagcagcag

121 gtctctttga caaacctgca attttgggga aaagtcagcc caagaaaggc agggggccca

181 gacttatgct gtgtggcaaa agccctcttt gatggggcaa gggtaggact ggaaaagcag

241 agagatcttt ctggatgtcc tgggagagca gccctttggg tggtgggtgg aggctggagg

301 cagggaggaa tcccctcaca gtgagaaggg cccccaaacc caggcgagac agagggaggg

361 tcaagaacgc caaggcaaat gtcacttgtg ccttgttttt tccctaaaga aactaaacaa

421 agcggccgcg ttcggtggcc cctcaggaag gccggtcatt tcctgaggag atatcaggcc

481 agcccaggcc ccattgttcc cggtttccag ccatggctgc cattacctga ccagcgccac

541 agccggtctc tctgcaggcg ccgggagaag tgaccagagc aatttctgct tttcacaggg

601 cgggtttctc aacggtgact tgtgggcagt gccttctgct gagcgagtca tggcccgaag

661 gcagaactaa ctgtgcctgc agtcttcact ctcaggatgc agccgaggtg ggcccaaggg

721 gccacgatgt ggcttggagt cctgctgacc cttctgctct gtgagtgttt actctgtttc

781 cacatcactt taactccatg agcatcgaag cttctggaat caacatgttt cttatgtttc

841 ttgcaggttc aagccttgag ggtcaagaaa actgtaagtc tgatgtttcc actgtaacag

901 atgtttctac ctggcttcct cctttctctt ctgtgatgcc taaaacgcac attaaattgc

961 tggggtttga tacttctaac aattaaggaa aagaatccaa ttgagaacta aagtttatcc

1021 catgtgggca tttttagaaa ggcttagatc taagccaagt tctggtcagt gtgttttaga

1081 agtagcacac gtttccttgg ctggtctgaa agtagtgggt tatcttgatg aattgtttag

1141 tcagttacag atcaaactcc atgttctttt ctctgttctc acgactactc ttgactagtc

1201 taaaaatata ttaggttgtt gaaaagtaat tgtggttttt gccattactt tttaaaagat

1261 ggcaaaaaac acaattataa gtagcacaca ttttcttttt tttttccttt tttttttgag

1321 acagagtctc tgttacccag gctggagtgc agtggtgcaa tccggctctc tgcaaactcc

1381 gcctccaggg ttcaagggat tctcctgtct cagcctcctg ggtcgctgga attagagg

>) INFORMATION FOR SEQ ID NO: 2761: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2761

1 ttggcaggct ggtctcaaac tcctgacctc aggtgatccg ctggcctcca cctcccaaag 61 tgctgggatt acaggtgtga gccaccacgc ccggcctcac attttctaga tttcagtgca 121 ttgctgtttt ttgggatggg gaagtgattt ttttatttta atgagcaatt ccataattag 181 ttttttgttg ttttaccata atggcttatt tgaatattgt aaggtatccc caactgtttt 241 tatttgcaaa tgagatataa ttgatttgtt agacatatga agacagatcc tagtttaaat 301 tgttgctact ttttttactc ctaaatgata aaaatcacac actcgagctc

(2) INFORMATION FOR SEQ ID NO: 2762: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2762

1 ttggcaggct ggtctcaaac tcctgacctc aggtgatccg ctggcctcca cctcccaaag

61 tgctgggatt acaggtgtga gccaccacgc ccggcctcac attttctaga tttcagtgca

121 ttgctgtttt ttgggatggg gaagtgattt ttttatttta atgagcaatt ccataattag

181 ttttttgttg ttttaccata atggcttatt tgaatattgt aaggtatccc caactgtttt

241 tatttgcaaa tgagatataa ttgatttgtt agacatatga agacagatcc tagtttaaat EPI-109 1036

301 tgttgctact ttttttaatc ctaaatgata aaaatcacac actcgagctc

(2) INFORMATION FOR SEQ 10 NO: 2763: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2763

1 gctgtcccac agcccaccct tcatcacaat agtcctgaaa ctttttgggt tcagtaagga

61 aatctgtggg ccttctctcc agaaaaagca cacatttgca cacaattgga ggtagttgat

121 gagcctccta acacccaccc atgcacctcc caggggctgt gtcccccagg ttgtgaacag

181 tcactctgtg taaatagtga gacctacagg cagtaattca gtttggctgt gcttggctgg

241 tttatttaga aagatgataa tgttt

(2) INFORMATION FOR SEQ ID NO: 2764: (i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2764

1 gagctctcca agggcagaca ctgccagcct cactgttctc tgaaccccca gtatgggaca 61 gtgcttggca cagaaaaacc cccttaaatg tttgctatga atggtgctaa ggaagaaggc 121 agagaatgtc aaccagaggc caggcactgg caatatatac acggcccc

(2) INFORMATION FOR SEQ ID NO:2765: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2765

1 ataccttggc tcactgcaac ctctgcctcc caggttcaag cagttctcct gcctcagtct 61 cccaagtagc tgggattaca ggcgcccacc accacacccg gctaattttg tatttttagt 121 agagatgagg tttcaccatg ttggccaggc tggtcttgaa ctcctgacct caagtgatcc 181 acccgcctcg gcctcccaaa gtgctgggat tacaggcata aaccaccgtg cccggctggt 241 cca

(2) INFORMATION FOR SEQ ID NO: 2766: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2766

1 gagctcatcc agcaggcttc ttaaatcagg agcttgtaag ttgcatataa agacaaaaaa 61 gggagttcca aagagtaatg ctgtgggaaa tgacttgaat ttaaaccgtc accttgtttg 121 atctcatgga ctggtcagac accatttttg ttgtcgttgt tgttgttaaa ttaattgctc 181 agaatatagc agcaggcgca aattgtagta ctcgttttaa aattgaagat taaattttaa 241 attacccaac aaaggcctaa ctttgttaaa ag

(2) INFORMATION FOR SEQ ID NO:2767: (i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2767

1 gaattctacc gacagcctat ggttactgga tataagccaa ttctgttctg gggacttgcc 61 agaaatgaca caattggcca gttgacccac agcctagttc ctagcagaga ttggatagct 121 gattgagcgt tgtggctgtt ttgaggcttg accagagatt cctgccgttg gcagagggga 181 atctgtagtc tttgcttctt ggtagcaggt gaggctgaaa acgcaagtag caggctaaaa 241 actggtttca agtcctcacc atctggtgaa acctcagagc ccatcagata gaaaatgcca 301 gctgggactg tgctaattcg gtaaggcctg ggtggagaag gagggcctgg gcacgaccat 361 ctggtttcgg aatggaggta gcagtcattt attaagtact taatgtatat cgggcactgt 421 acaggagacg ttctggctgt tctcctgtac atttcctgca aagacctaat gagatatgat 481 tactccatcc tacaggtaag gaaactgagc tcagagagtc tagctgccca gggtcacaca 541 gtaaatgatg agccaggact tgaacacttg actgcttgaa tcctgtactc cctccagggg EPI-109 1037

601 ccaagatgtg gcagctcaca gaatgcctat atcttttttt ttttttgtct tttgagacag 661 tctcactctg ttgcccaggc tggagtgcag tggtgagatc tcacctcact gcaacccccg 721 cctcccaggt tcaagtgatt cttgtgcctc agcctctcaa gtagctgggt tacaggcctg 781 caccaccaaa cctggctaat ttttgtattt ttagtagaga gggggtttca ccatgttggc 841 caggccagtc tctaactgct gacctcaggt gatccaccca ccttggtctc ccaaagtgct 901 gggattatag gcgtgagcca ccatacctag ctctacatct ttatcactct gttcctttgc 961 cttggtggga aaagttgcag cttagtacca actgcctcct gcttgagcca ctgtgcacag 1021 ttactatcag cctggccctg taggcacgta gaacccctgg actcaatact gcataggatg 1081 ggataagacc acatctgatg tggtgaaggt caccgggatg atgttgtttc tgagataaca 1141 ggtatgtctg ccttccttcg ggttgcattt agctttcaca atcaacagtg ttgacatgaa 1201 gagcctgccg gactggacgg tgcaaaatgg gaagaacctg accctgcagt gcttcgcgga 1261 tgtcagcacc acctctcacg tcaagcctca gcaccagatg ctgttctata aggatgacgt 1321 gctgttttac aacatctcct ccatgaagag cacagagagt tattttattc ctgaagtccg 1381 gatctatgac tcagggacat ataaatgtac tgtgattgtg aacaacaaag agaaaaccac 1441 tgcagagtac cagctgttgg tggaaggtga gtccttggaa ctgagcacag gcaagcagat 1501 ggagcatagc acacagtggc gtgaataaca gctgtgaatg aatagtgaca ctggacttaa 1561 ctctccaccc atcaccctct cattcatctg cctggcattt tccttacctg aatacgtaag 1621 cactagacat attccccaat aggcaggccc ttccttcctt ccttccttcc ttccttcctt 1681 ccttccttcc ttccttcctt ccttccttcc ttcctttctt tctttgatgg agtctcactc 1741 tgtcacccag tctggagtgc agtgggtgat ctcggctcac tgcaacctct gcctcccagg 1801 ttcaagcgat tctcctgcct cagcctccca agtaattggg attacaggtg tgtgccacca 1861 cacctggcta attttgtatt tttagtagag atggggtttc actgtgttgg tcaggctggt 1921 ctcgaactct gacctcaagt gatccacctg cctcccaaaa tgcttcttca tctcgctcta 1981 taaattacaa tttctttctt caagactcaa ctcaatgatg ttttgccaaa acaaaatggg 2041 tctaccccag ggtgccagtc agtacagctc tgatgctctc tctacaggca atggtatttg 2101 tgtgtataaa ggccacagcg gtgtgttaag acacctcgtt ctgcagtcac tctgcctggg 2161 tttcaatctt gggtcaagtc cttaacatgc tctaaacttc aaaatcctca ccagtaaaag 2221 gaagataaca acgataccca tttcaggcaa ttattgagag ggttaaaagt gtcatgtggg 2281 tagagtgctt agcaaaattt ccagcaccta gtgagttcct aataaataga aatgtattta 2341 tttatttgag acagagtctt cctctgtcac ccaggctaaa gagcaatggc gcgaccttgg 2401 ctcactgcaa cctctgtctc ctgggttcaa gcgattctcc tgtctcagcc tcccaagaaa 2461 ctgggattac aggcacgcgc cactgtgcct ggctaatttt ttgtattttt agtaaggatg 2521 gggttttacc atgttggcca gcctggtctc gaactcctaa cttcaagtga tttacccacc 2581 ttggcctccc agagtgtcag gattacaggt gtgagccacc atgcccggtc cacaaatatt 2641 ctatttcact cagtattggc atccgttctt acacatctgt ctgctcttct ggatagtgaa 2701 attgtaaaga cagagatggt gtttgggttt attcttatat cttgaacaat gaatctggct 2761 catagtaggc attcagtcaa tgttcatgga ataaattaaa gtcagtccta gcctgtgggt 2821 gcattcaata aagggtaaca acaatcacag tgacactgac aaatactggg ttacctttcc 2881 cctctaagca tcatctgttg ggaatctgat tgtgtcctct tcccaatagg attataaacc 2941 attgaaaaca ccaagtacat cttgaccata ttttattttt taaatttatt tatttattta 3001 tttatttatt tttagacaga gtctcactct gttgcccagg ctggagggca gtggcacgat 3061 ctcagctcac tgcaacctct gccttcgggg ttcaagcaat tctcctgcct cagcctccaa 3121 gtagctggga ttacaggtgc ctgccaccat gccggctaat tttgatttaa tagagatggg 3181 gttcgccatg ttggccaggc tggtctcaaa ctcctgacct caggtgatcc acctgcctca 3241 gcctcccaaa gtgttgagat tacagatgtg agccacctcg cgtggcctta gtggtgattt 3301 tggtggaccc atcacccgag cagtgtacac tgtacccagt gtgtagtcat tttatccctc 3361 gctccctccc actctttccc ctgagtcccc aaagtccact gtatcattct tatgcctttg 3421 tttcctcata gcttagctcc cattgagcat attttatatt ttttcctttc ttttcttctc 3481 ttttttgaga cagggtctct gttgcccagg ctggagtgca gtggtgggat tactgctcac 3541 tgccgcctca acctcctagg ctcaagtgat tctcccacct cggcctccca agtagctggg 3601 actaccagtg cacaccacta actacccctg gctaatttta attttttttt ttgtagagat 3661 agcatttcac cgtgttgccc aggctggtct ccaactcctg ggctcaagag atccacccac 3721 ctcagcctcc agattttata tatttcaaag tgcctagtac tgtgctgggc acatacctgt 3781 tcatttatta cctggtaggt cgcactgggt gttcagagaa caaaaaagag ccctctcatg 3841 ggatcaacta cagtcactca gcggagggga gggcttgtgt ctctcaatca ggctgatact 3901 gacagacttt cttcttcaat caggctgata ctgacatgac tttctacttt ccccgtagga 3961 gtgcccagtc ccagggtgac actggacaag aaagaggcca tccaaggtgg gatcgtgagg 4021 gtcaactgtt ctgtcccaga ggaaaaggcc ccaatacact tcacaattga aaaacttgaa 4081 ctaaatgaaa aaatggtcaa gctgaaaaga gagaagaatt ctcgagacca gaattttgtg 4141 atactggaat tccccgttga ggaacaggac cgcgttttat ccttccgatg tcaagctagg 4201 atcatttctg ggatccatat gcagacctca gaatctacca agagtgaact ggtcaccgtg 4261 acgggtcagc atctgctccc ttcctcatcg ttctttgtgg tttctggt

(2) INFORMATION FOR SEQ ID NO:2768: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2768

1 gttctagaga agaaaggttg aattttaaag ttagttagga acaatagaaa agtttgaaaa 61 ggggaagcag caaaaagagc agaagaggct cctcttgccc aggtttgcac ctgagtccaa 121 ccaggttgtc ttcctctctt gcagaatcct tctctacacc caagttccac atcagcccca 181 ccggaatgat catggaagga gctcagctcc acattaagtg caccattcaa gtgactcacc EPI-109 1038

241 tggcccagga gtttccagaa atcataattc agaaggacaa ggcgattgtg gcccacaaca

301 gacatggcaa caaggctgtg tactcagtca tggccatggt ggagcacagt ggcaactaca

361 cgtgcaaagt ggagtccagc cgcatatcca aggtcagcag catcgtggtc aacataacag

421 gtagggctgc tgctgccgga gggtgttggc atatggcggg ctcaagaggc caccatgctg

481 caatccagca tggccaaaga gagctgatca tttcctgccc ctgcttatct gaatgaatgt

541 gctcagatgg ggctttggtg ctcgtgggag gaaaccactg cagagcgagt taacagtcta

601 ctgtgcgtgt tgagggtaca ggctccggca ccaaagctta accctgccgc tcactgcttc

661 tgtgaccttg ggtgagttat tgaacgtgcc gcagcgctgt gagatggtga taatgacctt

721 ttaggactgc tataatgatt aatgagataa ctatactgta agcatgagct gagagatttg

781 tacagagtaa gactctgaaa cactggttaa tgttttcatt actctgttat atttctccat

841 cccctgtgac aagcactatg ctagatc

(2) INFORMATION FOR SEQ ID NO:276g: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:276g

1 gaattccggc ctgtgaatcc atctggttct tggacttttt ttggttggta agctattgat 61 tattgccaca atttcagatc ccgttattgg tctattcaga gattcaactt cttcctggtt 121 tagtcttggg agagtgtgtg tgttgaggaa tttatccatt tctcctagat tttctagttt 181 atttgcgtag aggtgtttgt agatattctc tgatggtagt ttgtatttgt gtgggatcgg 241 tgatgatatc ccctttatca ttttttattg cgtgtatttg attcttctct ctttttttct 301 ttattaggct tgctagcggt ctatcaattt tgttgatcct ttcaaaaaac cagctcctgg 361 attcattaat tttttgaagg gttttttgtg tctctatttc cttcagttct gctctgattt 421 tagttatttc ttgccttctg ctagcttaag gagtttcatt cttgttgccc aggctggagt 481 gcagtggagc aatctcggct cactgcaatc tctgtctcct gggttcaagg gattctcttg 541 cctcagcctc ccgagtatct gggattacag gcgcccacca ccatgctggc taattttata 601 tttttagtag agatggggtt tcaccatgtt gcccaggctg gtctcaactc ctgacctcag 661 gtgatccacc cacctctgcc tcccaaagtg ctgggattac aggcatgagc caccacacct 721 ggccacaagt tgcaaaactt ttctaatcct tgtcattgaa ataaattgga ttaacaagaa 781 aggaaaacct gccattggaa tcctaggcaa agaatgaacc ctagctcctt actggggtga 841 tcgttaggta catgagaagc aaaggaaaac tttttgctgg aagttggaag ttggttctgc

901 caagagcacc tgagccaagg gcctctccag gaagggtctt tagggtggtg gccagacaca

961 tctcgctcca ttcccactca ctgtttttca gaactatttt ccaagcccga actggaatct

1021 tccttcacac atctggacca aggtgaaaga ctgaacctgt cctgctccat cccaggagca

1081 cctccagcca acttcaccat ccagaaggaa gatacgattg tgtcacagac tcaagatttc 1141 accaagatag cctcaaagtc ggacagtggg acgtatatct gcactgcagg tattgacaaa 1201 gtggtcaaga aaagcaacac agtccagata gtcgtatgtg gtgagtatat tgttgcgact 1261 cagaggacat ccggggttga atgggagaaa ggaaatttat ctgcagctgc cgccctctcc 1321 ggtctccggt ctgagcagac tcaggcaggg taagaactag agggagagaa gtgcgaaatc 1381 aaaggccaaa gaaacaagga ggtattcctg ctcagaacac tgattcactg atgatgatgt 1441 ggcctctgac ttgcaagatt ctggcaagat tctgcctcct ggagcaagac ccacccaaaa 1501 gttcaggaag gaaacactac ttagtcaatg ttaaactttt cttttttttt tttgagacgt 1561 gtcgcccagg ctagagtgca gtggcacgat agctcactgc aacctctgcc tcctaggttc 1621 aagtgatctc ctgcctcagc ctcccaagta gctgggatta caggtgccca ccaccacgtc 1681 tgcctaattt ttgtattttt atttttatta cttttattta tttatttatt tatttttttt 1741 cggtctgtca cccaggctgg cagtgccagt ggcacaatct gggcatcact ggaaagcatc 1801 cgcactcctg ggtacacgag cattctcctg cctcagccct cccaagtggg tgtggactac

1861 aggacacacc gt

(2) INFORMATION FOR SEQ ID NO:2770: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2770

1 tcacttgagt ccaggagttc aagaccagcc tgagcacata gtgagaccct gtctctacaa 61 aaaataaaga attagccagg tgtggtgtgc acctatagtc ccagctactc gggaggctga 121 ggtaggagga ttgcttgatt ctgggaggtt gtagtgagct gtcatcgcac cagtgcactc 181 cagcctgggt aatagagtga gaccctgtct caaatacaca cacacacaca cacacacaca 241 cattttgttg gctacttgt^'t gtactttttc tatgttttct gtgtctttgc tcaacacaag 301 aaaagtatat tatgtgtgca tgtgcgtgtg agatatggta aaatatgaac atgtatttct 361 ggggatgtaa tgttttcctt gaatttctgt cattctctgt tttgcttatt gtacttctct 421 ttccctttcc cttctcacca cacacacaca cacacacaca cacacacaca cacagcctgt 481 cagtctcata ggtgtcctat aaaggtaaat ggcaggcagg catttgaaat tacagcaggg 541 atagaaagca aaactcaggc tttggaggag gaacctcttg tgctggatgc tttgttttta 601 ccttcagtgc cttttggatt gtttctccct ctgttctaga aatgctctcc cagcccagga 661 tttcttatga tgcccagttt gaggtcataa aaggacagac catcgaagtc cgttgcgaat 721 cgatcagtgg aactttgcct atttcttacc aacttttaaa aacaagtaaa gttttggaga 781 atagtaccaa gaactcaaat gatcctgcgg tattcaaaga caaccccact gaagacgtcg EPI-109 1039

841 aataccagtg tgttgcagat aattgccatt cccacgccaa aatgttaagt gaggttctga 901 gggtgaaggt gataggtaag ttgctgtgct gtgagaagaa atcatgtggg cttggggcat 961 tctttcaccc ccagggactg tggggacaat aagagaagta gggggccagg tgcggtggct 1021 catgcctgta atcccagcac tttaggaggc caaggccggt gaatcattga ggccaggagt 1081 tcaagaccag cctggccaac atggtgaaac cccatctcta ctaaaaatac aaaaattagc 1141 tgggcatgat ggcgtgcgcc tataatccca gccactcggg aggctgaggc aggagaattg 1201 cttgaaccca ggaagcacag gttgcactga gccaagttgc gccattgcac tccagcctga 1261 gcaacaagag cgaaactcca tctaaaaaaa aaaaagcgag agaagtagtg ggtgcttatg 1321 caaagtccat atactagata tgcaccaaag cagggccaag gttcagtaaa ggaggctgga 1381 aaatatttgg gggctattga tgaggacaat ataatctctt tccagaacct ttcaacaaac 1441 tgctaaaaga tgataagcat gaaagtgtcc tgactgcagg aagcactgaa gttgtgcata 1501 tgggcttccc ttagcacttt ctccttttca gatacactgt tctgagaatt gtagatcagg 1561 actctgctgt tgtgactcct agccggggaa ccctgccttg tgtgaattcg agattagcct 1621 ggccaacatg gtgaaatcct gtctctaata aaaatacaaa aaattagctg ggtgtggtgg 1681 tgggcacctt taatgccagc tactcgggag gctgaggcac aagaatcatt tgaacctggg 1741 aggcagaggc tgcagtgagc caatatcatt ccgctacact ccagcctggg caacggagca 1801 agactccatc tcaaaaaaaa aaaaaattaa cattacatag actaagcacc taatggtgtg 1861 aggcatacaa aaaagaagac atattctttg tttcaatgct gtggtaagaa acacaagctc 1921 tcctaatgaa aatgatggac aaacatctga atcatactac caataagcat agaaaaaatg 1981 ttgggggtca tgtttggttg tcacgtgaac tatatcctta cagtgatggt gatagtaatt 2041 tagggtatgc cagacttcat ctagcttaag tgggtaaaca ttgtgaaaaa gctgggctag 2101 gtgccagggc ttgagaatgg gtggccagag aaggctgaag atggctgaac atctccagca 2161 aacacatgag ccaaaaggtc ccatggggca cttcaaaaga ctgtgcgcag ccaggtgcgg 2221 tggctcacgc ctataatccc agcactttgg gagaccgaat ggggtggatc acttgagccc 2281 agaggtttgt gactagcttg gccaacatgg caaaaccccg tctctactaa aaatacaaaa 2341 attagcccag cgtggtggtg ggtgtcctgt agccccagct actcaggtgg ctgaggtggt 2401 agaatcactt gaatccagga ggcagaggtt gcagtgagcc aagatcgtgc cactgcactc 2461 cagcctgggt gacagagtga gactctatct ccacaaaaaa aaaaaaaaaa aaaaaaatta 2521 aaggactgtg gccaaatcag atggctggaa acaaaggctg gagtttggga atggagaatc 2581 accggatatg agctgaaaaa gtggctgagc ctaagcgtga caggtgtcag gtgccagtct 2641 caggagtagg caattgtcct gcatgcagtg aaaagccaga agatggaagg aaggacagga 2701 tgcaaatgag ttctcggaac gatccacctg gtggctgggt cagggagcag gcatggtgac 2761 ttcagacctc atggtacgtt agaggctaat gtgaagccca tgtgaagctg ttggtttaaa 2821 ctgggtcgat atcagtggca cacatttact gaccatgtgt ccagccctgt gtgaagtact 2881 gtagtaaatt gctccaatgg aaactcacaa taaccacaga aggccagtaa cagcattgtc 2941 gttattttat catgacgcaa ctgaggctta gggcagacag ctggtgggtg gtgggactgg 3001 gatttgagcc cactggtgtc ccaggcccgg agcttggctt cttccattgt cttaccacag 3061 cctgcactca caggagagtg actcataagt tacaatacca tctgctgacc atctgctctc 3121 acactagaag gaaagtctac ttggggagac aatttaggat ccgaattttg gtagttgagg 3181 atggagctag gaaaagcgga tacaggaggt agccaagttc tgcttggacc tgcagggagt 3241 gaggctggcc gggctccagg tggaaatccc caggtgaaaa gggagacttg gagttcagga 3301 aagtaacctg gactggagcc ataggtttag gtgtcagtgg ctcagagaca gaagctcagc 3361 gtgtaggtga aatcacccag gaggagaatg gggatggaaa actgaggatt gaattttgca 3421 aaatgttcat acttccgggg aaaacaaaga ataaccagtg aataagaaag gggtgccagg 3481 taagaaggga agagaatcag agtcatgagg aaccccagaa ccccagaaaa agctgagttc 3541 cacgtaagac ctgggcaaca gtgaagtatg gagagcccaa gattgggagc gtggaggaag 3601 agcatccacc actgaattta atcagccccg gactcaggga cgttggttgg ggaatcaagt 3661 gaccttccca gtttcttcaa aacttgagag agagtgcagt gtcacaagat tgtgactaca 3721 aaagagtgca gtcagatttc aggggtaaca agaaagtgtg aaataaggga gtcaaagcat 3781 aaaggaaaaa ggagaaaaaa tggccgatag ctagagaagg cgtgggtcaa gattgtctgt 3841 ggcctggcat ggtggcttat gcctgtaatc ccagcatttt ggaaggccga ggtgggcaaa 3901 tcacctgagg tcaggaattc aagaccagcc tggccaacag ggcaaaaccc cgtctctaaa 3961 acaacaacaa caacaaaaaa atccaaaaag ttagctgggc ctggtgggcg cacctgtcat 4021 tccagctact cgggaggctg aggcaggaga tttgcttgaa cccaggaggc acacgttgcg 4081 gtaagctgag attataccac tgcactccag cctgggtgat aagagcggga ctctgtctca 4141 gaggaaaaaa aaaaaagttg agcagtggct gtctcatgtt cctcttcctc tgcccttctt 4201 tgctcagtgt gaatcctttt cctgcttttc agccccggtg gatgaggtcc agatttctat 4261 cctgtcaagt aaggtggtgg agtctggaga ggacattgtg ctgcaatgtg ctgtgaatga 4321 aggatctggt cccatcacct ataagtttta cagagaaaaa gagggcaaac ccttctatca 4381 aatgacctca aatgccaccc aggcattttg gaccaagcag aaggctaaca aggaacagga 4441 gggagagtat tactgcacag ccttcaacag agccaaccac gcctccagtg tccccagaag 4501 caaaatactg acagtcagag gtgagtcagg gtctccatag caagctgtgc tgtgggcccc 4561 caagggcaag accagaaaac accccccttg taagagggag tttgggggga gtctagctta 4621 tgtgactgaa ggctaggaga gtaatgtcct ccaggctctt ggttgcaagt gacagaaacc 4681 cactcaaatt aagtaaaaaa gagaaatcga ttattataag gaattgggag aatgtcacat 4741 cgttccaatt acaaattgtt ggcagactca ccattgagtc atcttgggtc aaacatccaa 4801 ccacagacca cctgtagcca aggggattgg gtcacgcaga acagacatga ttggggaacc 4861 acttatgtgg gtgtgggggc ggtttcctgg agaagaagag ggctgaaaac acatgccaaa 4921 aaggagtcta ctccacttga gccctggagt tggagaccag cctgggcaac atggtgaaac 4981 cctgtctcta caaaaagtac aaaaataggc tgggcgcagt ggctcatacc tgtaatccca 5041 gctactcggg aggctgagac atgagaatca cttgaaccca ggaggtagag gttgcagtga 5101 gcagagcttg ctccactgca ctccagcctg ggcaacagag caagactctg cctcaaaaat 5161 caaaccaaca aaaaatagct gtgtgtggtg gtgtgctcct gtagtcccag ctactcggga 5221 ggctgaggtg gaaggattgc tcaagcccag gaagttgagg ctgcagtgag ctgtcatcag 5281 cctctagcct gggtgacaga gtgagaccct gttcaaaaag aaagaaaaag aaaagagtct EPI-109 1040

5341 acccagcaaa gctggtttgt tccctccttg aggaccacag ctgacctcta tttgtagcag

5401 aaacaatcat ttctgcacca gctctgagtg cagaacccct cagaggtaga tggatgctaa

5461 ggcaagctgc cagttacaag agctgtgaga atcagactga cttttgttgc ttaaggcctg

5521 atattatttc ttcctggcag aggaagagcc tatatacaaa aaaaattttt tgttttgttt

5581 tgttttcagt cattcttgcc ccatggaaga aaggacttat tgcagtggtt atcatcggag

5641 tgatcattgc tctcttgatc attgcggcca aatgttattt tctgaggaaa gccaagggtg

5701 agcatagttc tttccttcca tactgactgg tcgtccttgc caggaaacca gccagggatg

5761 cgtggtgctt ttctgacccc tggattcagc taggcaaaaa tgaaagctat tattttcctc

5821 attgggcaaa ccagaaaaga taaaatttgg gggaaattac atctttgtgt ggttagaaga

5881 agccatttct gtagatttgt ccacacctag tcctgtaatg cgtgtagagt ggggtgcaag

5g41 cgtcttggag acacacaaac atgcgcataa cacccacatg ttgcacacac acattg

(2) INFORMATION FOR SEQ ID NO: 2771: (i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2771

1 acctctttct tttctgtctt ttgaaaaaga gtgaatatat ttgccttctt tttctctctt 61 tttctgggta ttcaatcttc tgggaagtcc aaacgtagct gaaaagagtg ttccttcaca 121 gcttactagg agtaaaacaa aaagaaaaga aaagtgtttt ctatctatta ggttagtgca 181 aaagccattg gcgttttggc cattatagtg gtatggatgt gggtactgta tactgacttt 241 ggtttttcgt tttctgtttt taaagccaag cagatgccag tggaaatgtc caggtgagtg 301 tatttgtaag aagggggcgg ctgctctgtg agcacggtgg acatgtctgg agggagattc 361 tggtcattag gaagttttca gtggctcttg gcaaacttag aaaaatatag gccttccttg 421 ggtgtgagtt gtgtgtgtga gttgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtatctc 481 cgtggaagaa tgccaattgt cctttcatgg gaaggaatgg cttttattct gagatcatgt 541 ccttcctaca tgattatttg tgaaatctcc ctttctttat gaaattataa tggtagtaga 601 taatttttta aaatttgaca aaatagagtt ggcctttaaa aaatggtttt actaccttta 661 ctgttgttga aatcccaaat caaaagtata gaaatgattg ctctgttcca gagagaaaca 721 gtagcgtggg ataagaattt cagggggctt ggtagtagcc tgtgaaggac tccggtattc 781 atgtgtgctt tggtctgatg ttatttaata ggaaagtt

(2) INFORMATION FOR SEQ ID NO:2772: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2772

1 aaaaaaaaaa aaagtttttt tacataatcc ttggagctgc caaaaaatat ttgttttcca 61 aatgagagag taaagttttc cttaccttgg aaaactcttc ctggttttct catgatcttc 121 ccttgtttac tttggtggtt tggggttaga acaataacaa caacaaatat atctatatat 181 tgttttctgt ttttatattt cattttaaag gccagcagta ccacttctga actccaacaa 241 cgagaaaatg tcagatccca atatggaagc taacagtcat tacggtaaag tcatgttctc 301 ctgccattta taattccccc caacttgcta catacttcct tacccctctc agaagcagaa 361 tatgtaagtg gtgggattac agttggaaga gaaaccctgg cttcaacagg gtacttcatc 421 tcatcagcca ctgggccatg taatatacgg aaacgtaaaa ggaaaggtaa catattttat 481 tctaactttg ccaccttcca aactccccgt agaagaaaga tggagaataa tcataatgcc 541 ttcaaagact ttgaacattg ctccagcgta atattataat tctccatttt caagacagag 601 acagatattg aatgaaaca^'t tggtaaacat cttctcagat ggaattatta caagcacaag 661 acagttttac ttcaaatttg gcacaaaggg aaagcaattt caatattctc tcagtaaagg 721 cataaataaa gtgttccaac taagaaaata tctattcata aggctcatca gtagcttcag 781 ggtcagctca gctgaatgag taggcagtcc taggagttct taatcccagg ttagtaagaa 841 aattgctcaa gcatttcagc aggatgctac ttacttccca gaggggggta ttattacatc 901 acaaaaagtc ctgtcccaga ccaaatttgg ggacactctt cctctt

(2) INFORMATION FOR SEQ ID NO: 2773: (i) SEQUENCE CHARACTERISTICS : (A) LENGTH: _ base pairs .(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2773

1 atagccacga ctcaaatata ttgatcttag aatctaaaag acttaggtct gggcgcggtg

61 gctcacgcct gtaatctcaa cactttggga ggccgaggta ggtggatcac ttgaggtcag

121 cagttcaaaa accacctggc caacatggtg taaccctgtt tctactaaaa atacaaaaaa

181 ttagctgggc atggtggtag atgtttataa tcccagctac tcaggcaggc tgaggcagga

241 gaataccctt gaacctggga ggtggaggtt gcatgacctg a

1 tggacctcaa catgcacacc agtccgagca acaagagcga aactccatct caaaaaagaa EPI-109 1041

61 agaaagaaag aaactatatt caggccaggc atggtagttc atgcctataa ccccagctct 121 ttgggaggct gaggtgggag gatcattgag cccaggagtt ggagaccagc ctgtgcaaca 181 aagcgagaca tggagaatgt ggaacgaggg acccaggacc cagagacagt gctggttgtc 241 actacactga ataaatcagg cttgactttg ttaggggtac tgaattttta aaagggtttt 301 agaaaactag aatttccctt gtcactcacc ctaattgtta tttttcaact aggtcacaat 361 gacgatgtca gaaaccatgc aatgaaacca ataaatgata ataaaggtaa ttatctaatt 421 acatgttttt attagaacca acttttacat taaaaaaaag actcatagga aaagaaaact 481 aaaacttgaa ggactgtgga taatttccca cctctcttaa tgaccctgta cccagccgat 541 gtgtcaatga aggtagctag ctgctttcac cagagatgct atctagtgtc ctcagtggga 601 agtacctaaa tcaaagtagg gaagaactgg gttatactca aaaaa

(2) INFORMATION FOR SEQ ID NO:2774: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2774 1 acaacaactc tgtggtttct ttaggcagag cctctgaact cagacgtgca gtacacggaa

61 gttcaagtgt cctcagctga gtctcacaaa ggtaagtgcc actcgagtga gtccccaggc

121 attcgctttg gcttgggttt aaaccccagt ggtggcgggg gtgctgtgtt cagtgagaag 181 agtctgtgca ccctcagtcg ctccaaagga agtgattagc agacctaccg gcctgctaag

241 actggaagga gcaaggcccc tggcctggcc tgtctctgag ctgtaaaatt tcaataattt

301 aaaagaaaaa aagaaaaggc caggcactgt ggctcacacc tgtaatccta gcactttggg

361 aggccaaggc gggtggatca cctgagatca

I ) INFORMATION FOR SEQ ID NO: 2775: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2775

1 tatattttat atattaatat ataaatataa atacatatat aatatataat atatgttttc 61 tttgtgtata atatatattt tataatattt tatatatttt tattttttat ttttatatat 121 tttatatata atatttttat atttatatta tttatatatt ttttatttta tatatatata 181 tatatttttt tttttctttg ttgagacgga gtctactctc tgcccaggct ggggtgcagt 241 tgcgagatct

(2) INFORMATION FOR SEQ ID NO:2776: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2776

1 tgcaaacctc tgcctccggg ttaaagcagc attctcctcc ctcagcctcc cgagtagctg 61 ggattacagg catgtcaccg ccacagccgg gtaatttatt tatttttttt ttgtattttt 121 aagtagagat gggatttcac catgttggcc agcgtgaact cgaacttctg acttcaaaag 181 atccaccccc ctcagcctcc caaagtgctg ggattacagg tgtgag

(2) INFORMATION FOR SEQ ID NO: 2777: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2777

1 gaattcaatt tgagttttcc agacccgtcc tcctccttgg cagctaagga gcagtgtggg 61 aagtcaggcc tgagcctcag gtgttccctc tctgccttcc tgtgggtgga gagccaggta 121 ttaccaggta cgaaaagggg ctttgtgggt acaaggctca gtggtgagta catttgacct 181 ggtcttgacc aagccagttc cctgctctca agacttcctc ctcctatgga ggaggggttg 241 ggaaccacat ccagctctga ccctagtggc aggcgaccaa gtggtcactt ggggtggagg 301 aggggcagga aggaactcag taaatcctgg tttgctgcat gtttgctctg agactaattg 361 ctgggaaaac cccatgacgt tggaagccat ctccttctct gttatcacag agaaaaacag 421 aagccaaaat aaagccccat ccggaaacat ccctgacagc agagacaaag agcctgccag 481 cctggtttac tcattagcaa gcagctgctc cctggagtgg gtggggagga gaggtagtga 541 tgagctgcaa ctctgcctgc ccacccatca cttaactggg cagatttggg ggcagctgca 601 actctagaag ctccaccaag aagcagaacc ccccaggccc aaacaccaag ccctctccct 661 ccatttattc ctcacctgcc ccagccccca ctgtgggcct gggtgggagg gtgagctggc EPI-109 1042

721 cgtgaccacc ccaccatgcg cctggtatat ggtgtttgat agcatttgtt gcagtgtctg

781 cgttgtttgt gcacctgtct gcctcacagc ctggagctcc tgaaagctgg ggaccaggcc

841 cgatcacctt tcctcttcca cagtgcgggg ttcacactag gtgtctagga ttctgctgag

901 tgagtgattt ggccaggcct gacatcaagc agagggtgtc ttggggatgt ggaggatccc

961 ccaatagggt tggggatccc tacagcttcc cttgagggcc ccacatctgg tgccacagaa

1021 agagagtgag gggtgtgtgg gcatctctgc tgtcccagca gtgtggtgcc ctggtagctc

1081 agccactcta ctgagttcca aatcctgttt gggtgccctg ggggaagtca gtgtaagggc

1141 ctagtca

(2) INFORMATION FOR SEQ ID NO: 2778: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2778

1 aaggagggaa atccacttga ccatggcaca ggaacccccc ttacccaatc tgggccttcc

61 ctttccccca tctgtaaaag gagaacagtg cccacacgac atcagcctct tttcctacag

121 tgagccttcc tggccctttg tgcagtagac aggagctggg aagtgcccag gttccatcct

181 gtttcctcag ggttggtggg tatgtatgtg tgtgcacacc ctgtgtgcat gagtgtgtgc

241 acacccagat tgcatgtttg tacatacagt gtgtatacaa tgtgtgtaga cacatcctat

301 acactgtatg agggtataca tagcatgtat acacattgtg tgcatgagtg tgcgtgtgta

361 tatgctgtgt gtgtattttt gtatacacat cctgtgccca taccccagtg taaggtaaac

421 agatggcagg aagggcgccc ttgagtctcc tccaggtata cgccacaccc tgggtcagtc

481 atcatgctgc catattgaga gggtctagcc cagaggatct cagccctgtc tgcatattag

541 ggcccctgag gagatcctaa aaaaccagca ccagggaccc ccccagacca atccaaccag

601 aagctgcagt gaggcccagg agccagcagt gaaaacagcc agcccagctg tctatctctg

661 taagagttct cagtcccagc tattcctagg gtcactgaca acccccaggc tctaacccag

721 acctcaggat cttgttctgg atcccggggt ctgggctctc aggtgattgg gaggccatag

781 cccaaccctg cgttgaggga cctggcagaa tgtctggaca agggtcacgg tggcagggga

841 agaggagtgg gggcagcaag ctggaggctg caggcccttg ctggggggct ctccatccgt

901 gggcccctca ggtccagggg ttcctctggt gcatgtggcc ctgctccaca atggcctgct

961 gacctcctat tcccagactg ggagtgacgc tcgttagacc aagacctcct tcttcttctt

1021 cttttttttt tttgggaggt ggtgtgtcac tgtgttgccc aggctggagt gcagtggcgc

1081 aatcttggct cactgcaacc tctgcatcct gggttcaagc gattctcgtc ccttagctct

1141 cgagtaactg ggatcacagg gacgcaccac catgcccggt taattttttg gaatttttag

1201 tagagacggg gtttcggcat gttggccaga atggtctcaa cctcctgacc tcaagtgatc

1261 ttgccccctc aacctcccaa agtgctggga ttacaggtat gagccacctt gcccagccag

1321 gatcttctaa catcagaaat gacaaggtct ctgggtgctt ctggacctgg ttctggtggg

1381 gtgcagtggt ggggtacagc cttgcctgca gagcctcaga ccttttccta tgactgcagt

1441 ggactgacct cgttcccaga ggcagctact aacttatgcc tggtcctttt tccagatcta

1501 ggaaagaagg acacagagac agtgtacagt gaagtccgga aagctgtccc tggtgagtga

1561 gggtctccag tgccccagcc tgggggatgc cccctataat cactgatggg ggcttgggag

1621 tgggcagaga aaagaagaag caaagaaggg caaaaaaggg gtggcacctc ttacaccagc

1681 gctgtgggct tcctctctcc caccaccctt aaaaagtcac ctcgggtcac atttactatt

1741 catgtagtca acgagcgctt cttgaatgct tactgacccc agccggtgac ccttacctgc

1801 tccccacaca ggccctggtg gctggggttc cccaaggtct tggacgtcga gtgttttgct

1861 ttggagaccc ccagtagctt cagcctttct tcttgttttc ttttttctct tttttttttg

1921 gggatacgga gtctcgctct gtcactcagg ctggagtgca gtggtgcaat ctcgactcac

1981 tgcaacctcc acttcccgga tttaagtgat tctcctgcct cagcctccca agtagatggg

2041 attacaggcg cctgtcacca cactcagcta attttttttt tttatatttg ggagacagag

2101 tttcgctctt gatgcccagg ctggggtgca atggag

(2) INFORMATION FOR SEQ ID NO:2779: (i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2779

1 tgctgggatt accaagtgtg accccccgcc ccagcagctt cagcttttct gacaagaaga

61 ctgactttgg gagtgggtgt gggtttgcgg atctactcta tttcctttgg ttcggctgcc

121 cccacttcgc ttcccgtgac gacccactgc ttactcatga aagggcttcc cccagagctg

181 agcacagagc ttaagcagac ccggaactgg gggagctcaa caagtccttt ttttcggtgg

241 gggggtataa taactgtatt caattcaggt gaaatgaaat acacaatgac aacttttaaa

301 ttctgaaggt aagtcagcaa tccgaaagac gtaaacattg tgggggaaat agtgactgtg

361 tgagtatctc gctttgtaca gcagacctct atttaagtgg gttcttggaa agggaatcat

421 taaaatggtc caggacattt ctgcaaaggg tgcctactca gcctaggcgt ggtggctcat

481 taagcactca gtaagtgctt tatttattta ccccaaataa ataaataaat ataaaaggat

541 gactcctccg agtacagtcg ccaaaccagc agcagcaatc tcgggcccag cccagaccca

601 caaaactagt ctctggaatc tgaacttagc cagcttcaga tgtttctgat gctgccaata

661 tttgagaagc actgtttgtg ttttgttttg tttttttgtt tgaaacagag tctcactctg

721 tcacccagac tggagtacag cagtgccatc tcagctgact gcaactccgt gcaacacccc

781 ccagccccta aggcttaagc gatcctccca agtagctaga accacagaca cacaccacca EPI-109 1043

841 tgcccagcta agtttttgta tttttggtag agatgaggtt ttaccatgtt gcccagactg

901 gtgttgaatt cctgagctca agcaatccac ccccttcggc ctcccaaagt gctgggatta

961 caagcgtgag ccactgtgcc aggcaaaaag cactgtttta gaagaaccat ccaattctct

1021 gaggaccctg ctttttatct gaaatagcga tcacttctta attcactttt aaaagttggt

1081 atatctacaa gaagaataga aactcaaccc ttgtggaact tgaccctgaa taatttttga

1141 aaaaccaatt ctctggggaa tttttagctc aaatacctca ttt

(2) INFORMATION FOR SEQ ID NO: 2780: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2780

1 aaaaaaaaaa aaaaaaagaa gaagtagttt ctgcttttag tcagataaac aagctctggg 61 gagacttcct tctacatctg aaccagctca aaacaatcct tatgccaaag gggcatattt 121 tgtggtggca tattctgatt tccttcatct gctttagggc agctggctgt tcaagtgggt 181 tctctcgggg tctccaggtt ggttctaga

?) INFORMATION FOR SEQ ID NO: 2781: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2781

1 ctttctttct ttcctttctt tttttttttt ttgagacagg gtcttcgctc tgtcacccag 61 gctggagtgc agtggcgcga tcgcagctca ctgcaacctc cagctcccgg gttcaagtga 121 ttcttctgcc tcagcctcct gagtagctgg gaccacagct actgccacca cccccgggta 181 attttttttg tatttttagt agagacggtg tttcaccata ttggtcaggc tgatctcgaa 241 ctccagacct caggtgatcc acctgccttg gcctcccaaa gtgctgggat aacaggtgtg 301 agacaccacg cccggccaga tcatat

(2) INFORMATION FOR SEQ ID NO: 2782: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2782

1 gatcctatct acgggaaaca tgaagagtaa tattctactg tggcctgggt gaccctgggc 61 aagtcataga gcctctcaag accttggtca ccttctctgt gagatgaggt atgggctgga 121 ggcaggtcag tggtcctcgg gctttattaa aacatcaata gtttggcgca ccccactccc 181 tgtgaatttc ccattcacta ggtctggagc ggtgccgaaa acgtgcattt ctaacaggtg 241 tccacacgca gctgctcgcc gacacgctgg ggcccgggct ttgagaacca ctcttgatgc 301 agcatgttcc tttctgattg tgccacgcta aggctctgct tcttgttgga aggagtaggg 361 tctttctcac cctccagaaa tcctggaggg atctttcagc attggtgggc aggtaaaacc 421 cagaaacact gtgcttatta gagggaaggt tgtattgagt gacccccaat aaaacagggg 481 gcccagggcc gcgcgcagtg gctcacgcct gtaatcccag caatttggga ggctaaggcg

541 ggcggatcat gaggtcagga gatcgagacc atcctggcta acacggtgga aaccccatct 601 ctactaaaaa tacaaaaaat tagctggacg tggt

(2) INFORMATION FOR SEQ ID NO:2783: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2783

1 agataagcaa tagggcatgg gcaggcctgc ctccaaggag cagccccagg gccgaggaga

61 gagagctggc gctggcccag gggacttgag tttgatggga aagcttgcag acagtggggg

121 agctgcctgg tctttccagt cttggctttt ggctctaagc acagcttttt tttttttttt

181 tttaattgtt gtatcatgag gcgccttcca ctcagctgcc tccccacgtt aggggatgga

241 cacagcactg gcagggatcc tgtgtgtctc agtttcccta ttgactctct gtggcctaga

301 gatgtatggt agaattccac actatgcttt ttttccaccg tgtttttttt tttttttttt

361 tttgagacag ggtctctctc tgtcacccag gctggagtgc agtggcgcaa tcttggctca

421 ctgcaacctc cacctcccca ggcaggcccc tctgactcag ctgggactac aggcatgcac

481 caccagcacc cagcaaaata tttttatatt ttagtagaga tggggtttcg tcacattggc

541 caggctggtc ttgaactcca gagctcaagc aatccgcccg cctcagcctc ccaaagtgct

601 gggattacaa tgcccagccc actttttttt ttacttttta caattttatt cttaaaattg EPI-109 1044

661 tggtaaaaca catatcacat aaaatttacc attttaactc taagtatcca gctcagtggc

721 actaagacta cacttttggt tgtcatagcg tggtgaacag agaagagaat gctactgcgt

781 ctcgtggaga gaggccaggg gataccgcta aacatgcgac aatgcacagg acagtcccct

841 ccccaccaca aaacaccacc cagcccaaaa tttcaacagg gccaccatgg agaaaccctg

901 gccagaggaa ttcacctcct gcaactcctc caacaggaga gctggttttc ctctccagta

961 ccagcttgtg gctgccctct gtcttgggag ggtgacttaa gggcacatcc cacctgatta

1021 ctgtgggctc tggatgggtg ctgagtcttg gtctggggaa cag

(2) INFORMATION FOR SEQ ID NO: 2784: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2784

1 aaattaccca ggcatggtgg tgtgcgcctg tagtcccacc aacttgggag gctgaggcag

61 gagaattcct tgaatctggg aggcggaggg tgcagtgagc cgagatagtg ccagctgagg

121 caggagaatt ccctggaggt agaggttacg gtgagccaag atggcgccac cacactccag

181 cctgagtgac aaagcgagac tctgtctcaa aaaaaaaaaa ataaagaaaa ttttaaatga

241 agtgccaggg actttatgcg catgtcatgt ggagctagct acagggtccc ggggaagctg

301 tcttgcacaa aggagccata aacctctaag ggcactgccg gctgatgtct cctggctctc

361 gcctcctccc tcttttctcg acctgctcct gaccctgtga tgttgttggg gcagttgaac

421 tgggttattt gcgttgctca ctgccatgtc atcctttgtt ttgtagatgc cgtggaaagc

481 agatactctg taagtacaca tttcatatac attatattta aaagtactcc actgaacagt

541 gaaatatttc cagactcacc cacgcctgca ttcacacgaa ttcttccccg ctccctagcc

601 tgttcagacc agaagccctg ggcttctctg actagccttg gccagttctg atttcgaata

661 ttctctcctg caatttccat cattacatct cagcccacac gtgaagggat tgggactctg

721 gggtgcttag cgccaaacaa gcaaagcaca catttcgttt aacgccaaag tctaggctct

781 ggaagtgagg cagatctagg gtgtatgctt ggaggagtgg agcagctgac agctcattgc

841 aatttagccg atactaatta ccccctacac accaggccat cagctgcagg aggacaccca

901 agcttcttga cctcagttca ccttctgatg agggaatcag acatgtgatc acttatcata

961 aagccaagtg agctatgcca gagcctatgg gaacacagaa cagagaccta gctagtgccc

1021 tcttccccaa ggaatcattt ggaatggccc atgaagaatg aatggagtga tgatgccagc

1081 attgagggag aaagatcagc aggagcacaa gggtgaggga tgaccagttt caagcagtgt

1141 gggatgggaa agaagagtgt gacagtgaca agtgacggga gaaagataag tcagggctta

1201 aatccaaagg atttacatcc cttgttaaga agcttcattc tgtaggaaat ggagttagga

1261 atctgcattt ggcagatggg agggtttatg aaagacacag aggcccacgt tcaacttttg

1321 caaagacgtg tcttccaatc ccaacctttt tgtgagctac ccagcaatgc aggagttaac

1381 tgggcagcta atatctgaag aaatgaggca tttgccgcat aaacttcttt taggtctggg

1441 aagaactttc agcaaagatt tcaggtagct cttccagtgg cccctggctt cctttgtttt

1501 gcccatgtca ggactcttgt aaaacagagc tc

(2) INFORMATION FOR SEQ ID NO: 2785: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2785

1 gagctccagc tttccagctg tcttttgggt gagcctgtct tcctcaagct caagcttcct 61 tatctataaa gtggagatgg tgatgacaat gatgataaga gcaacctatt aggattttaa 121 ggatgaaatg agcaactgca accaccatat aaaagctgca agctgcaaac caccatataa 181 aagctggttg atctcaagct cttttcatca cttgggcaat agtaggtgtg gatgggggac 241 ttaacttgat ttggccatga aatgaccctg ccacatatgg agaatgtagc agttgcttac 301 ccaaggcata ggattcaacc aaggccaggc tttgacttag gaatcagaga cccacattaa 361 catttgactt cccgcttctt agccatgtca ccatgggcaa atttcttggc ctctcaagac 421 ctctgcttcc taatctgtaa actgggaatc ataaactccc tcacttggtt gttgcaaggg 481 ttgaatgagc ac

-) INFORMATION FOR SEQ ID NO:2786: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2786

1 ctatcaatct ccagagcttt ttctttttaa gtgtgagcga gtttattaga gaagtaaaga

61 gacccaagag tgcctactcc atagacagag cagccactgt gacactgtac ccattaaaca

121 ctaactctcc attgcccctc cagcaacccc tagcacccac tgtctacttt ctgtctctat

181 gtggttgtct atttgaggga catcacataa gtggagtcat atatttgtcc tttcatgtct

241 cccttatttc atttagcata acgttttcaa gggtttcctg tgttgtgaat atatcagaat EPI-109 1045

301 ttcattctct ttttaaggta gaatcatatc attttaaaac atttcagttg gaccatctaa

361 gttcagtcct tcattttcaa caattaaaaa acagccctca accgggtgca tctcacgtta

421 gctagagaca gaactggagc tagaagtcag atctcttacc aaagttgcct ttcttcttct

481 gtgggtaagt ggggcaccct tgggacgctg tgctgggcgt acatgggtgc ttgatgaagt

541 tacttggtgg actgatgtga ttgatgtcca acatgtatgc agggacagag gctatggtcc

601 ctacagagca ggcatggaga gaaggagaaa tacatacggg caggagccag gagagggagg

661 gtgtagtgag cagagaccgc gccactgcac tccagcctga gtgacagagt gagaatccat

721 ctaaaaaatt gcttactaaa gaagtggtct cctgaggtct taagacgttc ctggcaatgt

781 cttgagtggg tgggagagag cctccagtca ttgagctgtg gaatttcaga ggtgagaacc

841 acacctaacc cccaattact ttcccctgtt tgcctcagtg acacagctgc aggaaccctg

901 gtgggtgttg tattaagtaa atttgacctt tattctttgc agatctgtga aatgttgtct

961 tctgaggggc cacgtgtatc tgtagtgctg aggactcctt ggggcctctg aagtcacaga

1021 gagaacctgc agggtggggg accagtgtgt gacagccctg ctttgcattt tctttgagaa

1081 gtgctgtcat tttgcatttc tctccaccag gggaatcttc aatcttgaga ggtgtgatca

1141 taacttgcct tgtttcttgt cgctacagag aacggaaggc tcccttgatg gaacttagac

1201 agcaaggcca gatgcacatc cctggaagga catccatgtt ccgagaagaa cagatgatcc

1261 ctgtatttca agacctctgt gcacttattt atgaacctgc cctgctccca cagaacacag

1321 caattcctca ggctaagctg ccggttctta aatccatcct gctaagttaa tgttgggtag

1381 aaagagatac agaggggctg ttgaatttcc cacataccct ccttccacca agttggaaca

1441 tccttggaaa ttgggaagag cacaagagga gatccagggc aaggccattg ggatattctg

1501 aaacttgaat attttgtttt gtgcagagat aaagaccttt tccatgcacc ctcatacaca

1561 gaaaccaatt ttctttttta tactcaatca tttctagcgc atggcctggt tagaggctgg

1621 ttttttctct tttcctttgg tccttcaaag gcttgtagtt ttgggtagtc cttgttcttt

1681 ggaaatacac agtgctgacc agacagcctc cccctgtccc ctctatgacc tcgccctcca

1741 caaatgggaa aaccagacta cttgggagca ccgcctgtga aataccaacc tgaagacacg

1801 gttcattcag gcaacgcaca aaacagaaaa tgaaggtgga acaagcacat atgttcttca

1861 actgtttttg tctacactct ttctcttttc ctctacatgc tgaaggctga aagacaggaa

1921 agatggtgcc atcagcaaat attattctta attgaaaact tgaaatgtgt atgtttctta

1981 ctaattttta aaaatgtatt ccttgccagg gcaggcaagg tcgtcacgcc tgtaatccca

2041 gcacttcagg aggctgaggt gggcggatc

(2) INFORMATION FOR SEQ ID NO:2787: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2787

1 gaattccggg agaagtgacc agagcaattt ctgcttttca cagggcgggt ttctcaacgg

61 tgacttgtgg gcagtgcctt ctgctgagcg agtcatggcc cgaaggcaga actaactgtg

121 cctgcagtct tcactctcag gatgcagccg aggtgggccc aaggggccac gatgtggctt

181 ggagtcctgc tgacccttct gctctgttca agccttgagg gtcaagaaaa ctctttcaca

241 atcaacagtg ttgacatgaa gagcctgccg gactggacgg tgcaaaatgg gaagaacctg

301 accctgcagt gcttcgcgga tgtcagcacc acctctcacg tcaagcctca gcaccagatg

361 ctgttctata aggatgacgt gctgttttac aacatctcct ccatgaagag cacagagagt

421 tattttattc ctgaagtccg gatctatgac tcagggacat ataaatgtac tgtgattgtg

481 aacaacaaag agaaaaccac tgcagagtac cagctgttgg tggaaggagt gcccagtccc

541 agggtgacac tggacaagaa agaggccatc caaggtggga tcgtgagggt caactgttct

601 gtcccagagg aaaaggcccc aatacacttc acaattgaaa aacttgaact aaatgaaaaa

661 atggtcaagc tgaaaagaga gaagaattct cgagaccaga attttgtgat actggaattc

721 cccgttgagg aacaggaccg cgttttatcc ttccgatgtc aagctaggat catttctggg

781 atccatatgc agacctcaga atctaccaag agtgaactgg tcaccgtgac ggaatccttc

841 tctacaccca agttccacat cagccccacc ggaatgatca tggaaggagc tcagctccac

901 attaagtgca ccattcaagt gactcacctg gcccaggagt ttccagaaat cataattcag

961 aaggacaagg cgattgtggc ccacaacaga catggcaaca aggctgtgta ctcagtcatg

1021 gccatggtgg agcacagtgg caactacacg tgcaaagtgg agtccagccg catatccaag

1081 gtcagcagca tcgtggtcaa cataacagaa ctattttcca agcccgaact ggaatcttcc

1141 ttcacacatc tggaccaagg tgaaagactg aacctgtcct gctccatccc aggagcacct

1201 ccagccaact tcaccatcca gaaggaagat acgattgtgt cacagactca agatttcacc

1261 aagatagcct caaagtcgga cagtgggacg tatatctgca ctgcaggtat tgacaaagtg

1321 gtcaagaaaa gcaacacagt ccagatagtc gtatgtgaaa tgctctccca gcccaggatt

1381 tcttatgatg cccagtttga ggtcataaaa ggacagacca tcgaagtccg ttgcgaatcg

1441 atcagtggaa ctttgcctat ttcttaccaa cttttaaaaa caagtaaagt tttggagaat

1501 agtaccaaga actcaaatga tcctgcggta ttcaaagaca accccactga agacgtcgaa

1561 taccagtgtg ttgcagataa ttgccattcc catgccaaaa tgttaagtga ggttctgagg

1621 gtgaaggtga tagccccggt ggatgaggtc cagatttcta tcctgtcaag taaggtggtg

1681 gagtctggag aggacattgt gctgcaatgt gctgtgaatg aaggatctgg tcccatcacc

1741 tataagtttt acagagaaaa agagggcaaa cccttctatc aaatgacctc aaatgccacc

1801 caggcatttt ggaccaagca gaaggctagc aaggaacagg agggagagta ttactgcaca

1861 gccttcaaca gagccaacca cgcctccagt gtccccagaa gcaaaatact gacagtcaga

1921 gtcattcttg ccccatggaa gaaaggactt attgcagtgg ttatcatcgg agtgatcatt EPI-109 1046

1981 gctctcttga tcattgcggc caaatgttat tttctgagga aagccaaggc caagcagatg

2041 ccagtggaaa tgtccaggcc agcagtacca cttctgaact ccaacaacga gaaaatgtca

2101 gatcccaata tggaagctaa cagtcattac ggtcacaatg acgatgtcag aaaccatgca

2161 atgaaaccaa taaatgataa taaagagcct ctgaactcag acgtgcagta cacggaagtt

2221 caagtgtcct cagctgagtc tcacaaagat ctaggaaaga aggacacaga gacagtgtac

2281 agtgaagtcc ggaaagctgt ccctgatgcc gtggaaagca gatactctag aacggaaggc

2341 tcccttgatg gaacttagac agcaaggcca gatgcacatc cctggaagga catccatgtt

2401 ccgagaagaa cagataatcc ctgtatttca agacctctgt gcacttattt atgaacctgc

2461 cctgctccca cagaacacag caattcctca ggctaagctg ccggttctta aatccatcct

2521 gctaagttaa tgttgggtag aaagagatac agagggg

(2) INFORMATION FOR SEQ ID NO:2788: (i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2788

1 gaccagagca atttctgctt ttcacagggc gggtttctca acggtgactt gtgggcagtg

61 ccttctgctg agcgagtcat ggcccgaagg cagaactaac tgtgcctgca gtcttcactc

121 tcaggatgca gccgaggtgg gcccaagggg ccacgatgtg gcttggagtc ctgctgaccc

181 ttctgctctg ttcaagcctt gagggtcaag aaaactcttt cacaatcaac agtgttgaca

241 tgaagagcct gccggactgg acggtgcaaa atgggaagaa cctgaccctg cagtgcttcg

301 cggatgtcag caccacctct cacgtcaagc ctcagcacca gatgctgttc tataaggatg

361 acgtgctgtt ttacaacatc tcctccatga agagcacaga gagttatttt attcctgaag

421 tccggatcta tgactcaggg acatataaat gtactgtgat tgtgaacaac aaagagaaaa

481 ccactgcaga gtaccaggtg ttggtggaag gagtgcccag tcccagggtg acactggaca

541 agaaagaggc catccaaggt gggatcgtga gggtcaactg ttctgtccca gaggaaaagg

601 ccccaataca cttcacaatt gaaaaacttg aactaaatga aaaaatggtc aagctgaaaa

661 gagagaagaa ttctcgagac cagaattttg tgatactgga attccccgtt gaggaacagg

721 accgcgtttt atccttccga tgtcaagcta ggatcatttc tgggatccat atgcagacct

781 cagaatctac caagagtgaa ctggtcaccg tgacggaatc cttctctaca cccaagttcc

841 acatcagccc caccggaatg atcatggaag gagctcagct ccacattaag tgcaccattc

901 aagtgactca cctggcccag gagtttccag aaatcataat tcagaaggac aaggcgattg

961 tggcccacaa cagacatggc aacaaggctg tgtactcagt catggccatg gtggagcaca

1021 gtggcaacta cacgtgcaaa gtggagtcca gccgcatatc caaggtcagc agcatcgtgg

1081 tcaacataac agaactattt tccaagcccg aactggaatc ttccttcaca catctggacc

1141 aaggtgaaag actgaacctg tcctgctcca tcccaggagc acctccagcc aacttcacca

1201 tccagaagga agatacgatt gtgtcacaga ctcaagattt caccaagata gcctcaaagt

1261 cggacagtgg gacgtatatc tgcactgcag gtattgacaa agtggtcaag aaaagcaaca

1321 cagtccagat agtcgtatgt gaaatgctct cccagcccag gatttcttat gatgcccagt

1381 ttgaggtcat aaaaggacag accatcgaag tccgttgcga atcgatcagt ggaactttgc

1441 ctatttctta ccaactttta aaaacaagta aagttttgga gaatagtacc aagaactcaa

1501 atgatcctgc ggtattcaa'a gacaacccca ctgaagacgt cgaataccag tgtgttgcag

1561 ataattgcca ttcccacgcc aaaatgttaa gtgaggttct gagggtgaag gtgatagccc

1621 cggtggatga ggtccagatt tctatcctgt caagtaaggt ggtggagtct ggagaggaca

1681 ttgtgctgca atgtgctgtg aatgaaggat ctggtcccat cacctataag ttttttttaaccaaggaagg

1741 aaaaagaggg caaacccttc tatcaaatga cctcaaatgc cacccaggca ttttttttggggaaccccaa

1801 agcagaaggc taacaaggaa caggagggag agtattactg cacagccttc aaaaccaaggaaggccccaa

1861 accacgcctc cagtgtcccc agaagcaaaa tactgacagt cagagtcatt ccttttggccccccccaatt

1921 ggaagaaagg acttattgca gtggttatca tcggagtgat cattgctctc ttttggaattccaattttgg

1981 cggccaaatg ttattttctg aggaaagcca aggccaagca gatgccagtg ggaaaaaattggttccccaa

2041 ggccagcagt accacttctg aactccaaca acgagaaaat gtcagatccc aaaattaattggggaaaagg

2101 ctaacagtca ttacggtcac aatgacgatg tcggaaacca tgcaatgaaa ccccaaaattaaaaaattgg

2161 ataataaaga gcctctgaac tcagacgtgc agtacacgga agttcaagtg ttccccttccaaggccttgg

2221 agtctcacaa agatctagga aagaaggaca cagagacagt gtacagtgaa ggttccccggggaaaaaagg

2281 ctgtccctga tgccgtggaa agcagatact ctagaacgga aggctccctt ggaattggggaaaacctttt

2341 agacagcaag gccagatgca catccctgga aggacatcca tgttccgaga agaacagatg

2401 atccctgtat ttcaagacct ctgtcc

1 gaattccggg agaagtgacc agagcaattt ctgcttttca ccaaggggggccggggggtt ttttccttccaaaaccgggg

61 tgacttgtgg gcagtgcctt ctgctgagcg agtcatggcc ccggaaaaggggccaaggaa aaccttaaaaccttggttgg

121 cctgcagtct tcactctcag gatgcagccg aggtgggccc aaaaggggggggccccaacc ggaattggttggggcctttt

181 ggagtcctgc tgacccttct gctctgttca agccttgagg ggttccaaaaggaaaaaaaa ccttccttttttccaaccaa

241 atcaacagtg ttgacatgaa gagcctgccg gactggacgg tgcaaaatgg gaagaacctg

301 accctgcagt gcttcgcgga tgtcagcacc acctctcacg tcaagcctca gcaccagatg

361 ctgttctata aggatgacgt gctgttttac aacatctcct ccatgaagag cacagagagt

421 tattttattc ctgaagtccg gatctatgac tcagggacat ataaatgtac tgtgattgtg

481 aacaacaaag agaaaaccac tgcagagtac cagctgttgg tggaaggagt gcccagtccc

541 agggtgacac tggacaagaa agaggccatc caaggtggga tcgtgagggt caactgttct EPI-109 1047

601 gtcccagagg aaaaggcccc aatacacttc acaattgaaa aacttgaact aaatgaaaaa

661 atggtcaagc tgaaaagaga gaagaattct cgagaccaga attttgtgat actggaattc

721 cccgttgagg aacaggaccg cgttttatcc ttccgatgtc aagctaggat catttctggg

781 atccatatgc agacctcaga atctaccaag agtgaactgg tcaccgtgac ggaatccttc

841 tctacaccca agttccacat cagccccacc ggaatgatca tggaaggagc tcagctccac

901 attaagtgca ccattcaagt gactcacctg gcccaggagt ttccagaaat cataattcag

961 aaggacaagg cgattgtggc ccacaacaga catggcaaca aggctgtgta ctcagtcatg

1021 gccatggtgg agcacagtgg caactacacg tgcaaagtgg agtccagccg catatccaag

1081 gtcagcagca tcgtggtcaa cataacagaa ctattttcca agcccgaact ggaatcttcc

1141 ttcacacatc tggaccaagg tgaaagactg aacctgtcct gctccatccc aggagcacct

1201 ccagccaact tcaccatcca gaaggaagat acgattgtgt cacagactca agatttcacc

1261 aagatagcct caaagtcgga cagtgggacg tatatctgca ctgcaggtat tgacaaagtg

1321 gtcaagaaaa gcaacacagt ccagatagtc gtatgtgaaa tgctctccca gcccaggatt

1381 tcttatgatg cccagtttga ggtcataaaa ggacagacca tcgaagtccg ttgcgaatcg

1441 atcagtggaa ctttgcctat ttcttaccaa cttttaaaaa caagtaaagt tttggagaat

1501 agtaccaaga actcaaatga tcctgcggta ttcaaagaca accccactga agacgtcgaa

1561 taccagtgtg ttgcagataa ttgccattcc catgccaaaa tgttaagtga ggttctgagg

1621 gtgaaggtga tagccccggt ggatgaggtc cagatttcta tcctgtcaag taaggtggtg

1681 gagtctggag aggacattgt gctgcaatgt gctgtgaatg aaggatctgg tcccatcacc

1741 tataagtttt acagagaaaa agagggcaaa cccttctatc aaatgacctc aaatgccacc

1801 caggcatttt ggaccaagca gaaggctagc aaggaacagg agggagagta ttactgcaca

1861 gccttcaaca gagccaacca cgcctccagt gtccccagaa gcaaaatact gacagtcaga

1921 gtcattcttg ccccatggaa gaaaggactt attgcagtgg ttatcatcgg agtgatcatt

1981 gctctcttga tcattgcggc caaatgttat tttctgagga aagccaaggc caagcagatg

2041 ccagtggaaa tgtccaggcc agcagtacca cttctgaact ccaacaacga gaaaatgtca

2101 gatcccaata tggaagctaa cagtcattac ggtcacaatg acgatgtcag aaaccatgca

2161 atgaaaccaa taaatgataa taaagagcct ctgaactcag acgtgcagta cacggaagtt

2221 caagtgtcct cagctgagtc tcacaaagat ctaggaaaga aggacacaga gacagtgtac

2281 agtgaagtcc ggaaagctgt ccctgatgcc gtggaaagca gatactctag aacggaaggc

2341 tcccttgatg gaacttagac agcaaggcca gatgcacatc cctggaagga catccatgtt

2401 ccgagaagaa cagataatcc ctgtatttca agacctctgt gcacttattt atgaacctgc

2461 cctgctccca cagaacacag caattcctca ggctaagctg ccggttctta aatccatcct

2521 gctaagttaa tgttgggtag aaagagatac agagggg

1 cccgggttca agcgattctc ctgcctcagc ctcttgggta gctgggatta taggcgtgtg

61 ccaccgtgcc tggctaattt ttgtattttt attggagaca gggtttcacc atgttggcca

121 ggctggtctg aaactcctga cctcaggcaa tcctcctacc tcagcctctc aaagtgctgg

181 gattaccggc atgagccacg actcccggcc ccaaaggtca atcttaaagc tacaaggtat

241 cttttaaaag gagtaggaat aacgtatttt gaggcttaaa ggagtaggaa tagtgtattt

301 ttagatttga agccatcttc taaagggtac gatatttggt taacatgtca ctccttatcg

361 ccatggaaga agttaattct attctttttt tttttttttt gagatggagt ctcactctgt

421 tgcccaggct ggagtacaat ggtgtgatct cagctcactg caacctctgc ctcctgggtt

481 caagcaattc tcctgcctca gcctcctgag tagcagggat tacaggggtt ctccaccatg

541 cctgtctaat ttttgtattt ttttttttag tagaggtgga gtttcaccat gttggtcagg

601 ctggtctcaa acccctaacc tcatgatccg cccgccttgg cctcccaaag tgctgggatt

661 acaggcgtga gccaccatgc ccagccgtta attctattct tactgcttac tcccttattt

721 tgtatgttct tcttctatct tacatctttt gcttttgcta ttgcttaagc tagcctacgc

781 caagggtgct ctttgccccc tacttcctct gctattctcg cctcagttcc gctgcattcc

841 aagctcagcc tgccccagca gcaggtctct ttgacaaacc tgcaattttg gggaaaagtc

901 agccccaaga aaggcagggg gcccagactt atgctgtgtg gcaaaagccc tctttgatgg

961 gggaagggga ggactggaaa agcagagaga tctttctgga tgtcctggga gagcagccct

1021 ttgggtggtg ggtggaggct ggaggcaggg aggaatcccc tcacagtgcc atgagaaggg

1081 cccccaaacc caggcgagac agagggaggg tcaagaacgc caaggcaaat gtcacttgtg

1141 ccttgttttt tccctaaaga aaaaccttaaaaaaccaaaa agcggccgcg ttcggtggcc cctcaggaag

1201 gccggtcatt tcctgaggag aattaattccaaggggcccc agcccaggcc ccattgttcc cggtttccag

1261 ccatggctgc cattacctga ccagcgccac agccggtctc tctgcaggcg ccgggagaag

1321 tgaccagagc aatttctgct tttcacaggg cgggtttctc aacggtgact tgtgggcagt

1381 gccttctgct gagcgagtca tggcccgaag gcagaactaa ctgtgcctgc agtcttcact

1441 ctcaggatgc agccgaggtg ggcccaaggg gccacgatgt ggcttggagt cctgctgacc

1501 cttctgctct gtgagtgttt actctgtttc cacatcactt taactccatg agcatcgaag

1 gaattccggg agaagtgacc agagcaattt ctgcttttca cagggcgggt ttctcaacgg

61 tgacttgtgg gcagtgcctt ctgctgagcg agtcatggcc cgaaggcaga actaactgtg 121 cctgcagtct tcactctcag gatgcagccg aggtgggccc aaggggccac gatgtggctt 181 ggagtcctgc tgacccttct gctctgttca agccttgagg gtcaagaaaa ctctttcaca 241 atcaacagtg ttgacatgaa gagcctgccg gactggacgg tgcaaaatgg gaagaacctg 301 accctgcagt gcttcgcgga tgtcagcacc acctctcacg tcaagcctca gcaccagatg 361 ctgttctata aggatgacgt gctgttttac aacatctcct ccatgaagag cacagagagt 421 tattttattc ctgaagtccg gatctatgac tcagggacat ataaatgtac tgtgattgtg 481 aacaacaaag agaaaaccac tgcagagtac cagctgttgg tggaaggagt gcccagtccc EPI-109 1048

541 agggtgacac tggacaagaa agaggccatc caaggtggga tcgtgagggt caactgttct

601 gtcccagagg aaaaggcccc aatacacttc acaattgaaa aacttgaact aaatgaaaaa

661 atggtcaagc tgaaaagaga gaagaattct cgagaccaga attttgtgat actggaattc

721 cccgttgagg aacaggaccg cgttttatcc ttccgatgtc aagctaggat catttctggg

781 atccatatgc agacctcaga atctaccaag agtgaactgg tcaccgtgac ggaatccttc

841 tctacaccca agttccacat cagccccacc ggaatgatca tggaaggagc tcagctccac

901 attaagtgca ccattcaagt gactcacctg gcccaggagt ttccagaaat cataattcag

961 aaggacaagg cgattgtggc ccacaacaga catggcaaca aggctgtgta ctcagtcatg

1021 gccatggtgg agcacagtgg caactacacg tgcaaagtgg agtccagccg catatccaag

1081 gtcagcagca tcgtggtcaa cataacagaa ctattttcca agcccgaact ggaatcttcc

1141 ttcacacatc tggaccaagg tgaaagactg aacctgtcct gctccatccc aggagcacct

1201 ccagccaact tcaccatcca gaaggaagat acgattgtgt cacagactca agatttcacc

1261 aagatagcct caaagtcgga cagtgggacg tatatctgca ctgcaggtat tgacaaagtg

1321 gtcaagaaaa gcaacacagt ccagatagtc gtatgtgaaa tgctctccca gcccaggatt

1381 tcttatgatg cccagtttga ggtcataaaa ggacagacca tcgaagtccg ttgcgaatcg

1441 atcagtggaa ctttgcctat ttcttaccaa cttttaaaaa caagtaaagt tttggagaat

1501 agtaccaaga actcaaatga tcctgcggta ttcaaagaca accccactga agacgtcgaa

1561 taccagtgtg ttgcagataa ttgccattcc catgccaaaa tgttaagtga ggttctgagg

1621 gtgaaggtga tagccccggt ggatgaggtc cagatttcta tcctgtcaag taaggtggtg

1681 gagtctggag aggacattgt gctgcaatgt gctgtgaatg aaggatctgg tcccatcacc

1741 tataagtttt acagagaaaa agagggcaaa cccttctatc aaatgacctc aaatgccacc

1801 caggcatttt ggaccaagca gaaggctagc aaggaacagg agggagagta ttactgcaca

1861 gccttcaaca gagccaacca cgcctccagt gtccccagaa gcaaaatact gacagtcaga

1921 gtcattcttg ccccatggaa gaaaggactt attgcagtgg ttatcatcgg agtgatcatt

1981 gctctcttga tcattgcggc caaatgttat tttctgagga aagccaaggc caagcagatg

2041 ccagtggaaa tgtccaggcc agcagtacca cttctgaact ccaacaacga gaaaatgtca

2101 gatcccaata tggaagctaa cagtcattac ggtcacaatg acgatgtcag aaaccatgca

2161 atgaaaccaa taaatgataa taaagagcct ctgaactcag acgtgcagta cacggaagtt

2221 caagtgtcct cagctgagtc tcacaaagat ctaggaaaga aggacacaga gacagtgtac

2281 agtgaagtcc ggaaagctgt ccctgatgcc gtggaaagca gatactctag aacggaaggc

2341 tcccttgatg gaacttagac agcaaggcca gatgcacatc cctggaagga catccatgtt

2401 ccgagaagaa cagataatcc ctgtatttca agacctctgt gcacttattt atgaacctgc

2461 cctgctccca cagaacacag caattcctca ggctaagctg ccggttctta aatccatcct

2521 gctaagttaa tgttgggtag aaagagatac agagggg

1 tcttttggtt ttgctattgc ttaagctagc ctacgccaag ggtgctcttt gccccctact

61 tcctctgcta ttctcgcctc agttccgctg cattccaagc tcagcctgcc ccagcagcag

121 gtctctttga caaacctgca attttgggga aaagtcagcc caagaaaggc agggggccca

181 gacttatgct gtgtggcaaa agccctcttt gatggggcaa gggtaggact ggaaaagcag

241 agagatcttt ctggatgtcc tgggagagca gccctttggg tggtgggtgg aggctggagg

301 cagggaggaa tcccctcaca gtgagaaggg cccccaaacc caggcgagac agagggaggg

361 tcaagaacgc caaggcaaat gtcacttgtg ccttgttttt tccctaaaga aactaaacaa

421 agcggccgcg ttcggtggcc cctcaggaag gccggtcatt tcctgaggag atatcaggcc

481 agcccaggcc ccattgttcc cggtttccag ccatggctgc cattacctga ccagcgccac

541 agccggtctc tctgcaggcg ccgggagaag tgaccagagc aatttctgct tttcacaggg

601 cgggtttctc aacggtgact tgtgggcagt gccttctgct gagcgagtca tggcccgaag

661 gcagaactaa ctgtgcctgc agtcttcact ctcaggatgc agccgaggtg ggcccaaggg

721 gccacgatgt ggcttggagt cctgctgacc cttctgctct gtgagtgttt actctgtttc

781 cacatcactt taactccatg agcatcgaag cttctggaat caacatgttt cttatgtttc

841 ttgcaggttc aagccttgag ggtcaagaaa actgtaagtc tgatgtttcc actgtaacag

901 atgtttctac ctggcttcct cctttctctt ctgtgatgcc taaaacgcac attaaattgc

961 tggggtttga tacttctaac aattaaggaa aagaatccaa ttgagaacta aagtttatcc

1021 catgtgggca tttttagaaa ggcttagatc taagccaagt tctggtcagt gtgttttaga

1081 agtagcacac gtttccttgg ctggtctgaa agtagtgggt tatcttgatg aattgtttag

1141 tcagttacag atcaaactcc atgttctttt ctctgttctc acgactactc ttgactagtc

1201 taaaaatata ttaggttgtt gaaaagtaat tgtggttttt gccattactt tttaaaagat

1261 ggcaaaaaac acaattataa gtagcacaca ttttcttttt tttttccttt tttttttgag

1321 acagagtctc tgttacccag gctggagtgc agtggtgcaa tccggctctc tgcaaactcc

1381 gcctccaggg ttcaagggat tctcctgtct cagcctcctg ggtcgctgga attagagg

1 ttggcaggct ggtctcaaac tcctgacctc aggtgatccg ctggcctcca cctcccaaag 61 tgctgggatt acaggtgtga gccaccacgc ccggcctcac attttctaga tttcagtgca 121 ttgctgtttt ttgggatggg gaagtgattt ttttatttta atgagcaatt ccataattag 181 ttttttgttg ttttaccata atggcttatt tgaatattgt aaggtatccc caactgtttt 241 tatttgcaaa tgagatataa ttgatttgtt agacatatga agacagatcc tagtttaaat 301 tgttgctact ttttttactc ctaaatgata aaaatcacac actcgagctc 1 gctgtcccac agcccaccct tcatcacaat agtcctgaaa ctttttgggt tcagtaagga 61 aatctgtggg ccttctctcc agaaaaagca cacatttgca cacaattgga ggtagttgat 121 gagcctccta acacccaccc atgcacctcc caggggctgt gtcccccagg ttgtgaacag 181 tcactctgtg taaatagtga gacctacagg cagtaattca gtttggctgt gcttggctgg 241 tttatttaga aagatgataa tgttt

1 gagctctcca agggcagaca ctgccagcct cactgttctc tgaaccccca gtatgggaca 61 gtgcttggca cagaaaaacc cccttaaatg tttgctatga atggtgctaa ggaagaaggc 121 agagaatgtc aaccagaggc caggcactgg caatatatac acggcccc EPI-109 1049

1 ataccttggc tcactgcaac ctctgcctcc caggttcaag cagttctcct gcctcagtct

61 cccaagtagc tgggattaca ggcgcccacc accacacccg gctaattttg tatttttagt

121 agagatgagg tttcaccatg ttggccaggc tggtcttgaa ctcctgacct caagtgatcc

181 acccgcctcg gcctcccaaa gtgctgggat tacaggcata aaccaccgtg cccggctggt

241 cca

1 gagctcatcc agcaggcttc ttaaatcagg agcttgtaag ttgcatataa agacaaaaaa

61 gggagttcca aagagtaatg ctgtgggaaa tgacttgaat ttaaaccgtc accttgtttg

121 atctcatgga ctggtcagac accatttttg ttgtcgttgt tgttgttaaa ttaattgctc

181 agaatatagc agcaggcgca aattgtagta ctcgttttaa aattgaagat taaattttaa

241 attacccaac aaaggcctaa ctttgttaaa ag

1 gaattctacc gacagcctat ggttactgga tataagccaa ttctgttctg gggacttgcc

61 agaaatgaca caattggcca gttgacccac agcctagttc ctagcagaga ttggatagct

121 gattgagcgt tgtggctgtt ttgaggcttg accagagatt cctgccgttg gcagagggga

181 atctgtagtc tttgcttctt ggtagcaggt gaggctgaaa acgcaagtag caggctaaaa

241 actggtttca agtcctcacc atctggtgaa acctcagagc ccatcagata gaaaatgcca

301 gctgggactg tgctaattcg gtaaggcctg ggtggagaag gagggcctgg gcacgaccat

361 ctggtttcgg aatggaggta gcagtcattt attaagtact taatgtatat cgggcactgt

421 acaggagacg ttctggctgt tctcctgtac atttcctgca aagacctaat gagatatgat

481 tactccatcc tacaggtaag gaaactgagc tcagagagtc tagctgccca gggtcacaca

541 gtaaatgatg agccaggact tgaacacttg actgcttgaa tcctgtactc cctccagggg

601 ccaagatgtg gcagctcaca gaatgcctat atcttttttt ttttttgtct tttgagacag

661 tctcactctg ttgcccaggc tggagtgcag tggtgagatc tcacctcact gcaacccccg

721 cctcccaggt tcaagtgatt cttgtgcctc agcctctcaa gtagctgggt tacaggcctg

781 caccaccaaa cctggctaat ttttgtattt ttagtagaga gggggtttca ccatgttggc

841 caggccagtc tctaactgct gacctcaggt gatccaccca ccttggtctc ccaaagtgct

901 gggattatag gcgtgagcca ccatacctag ctctacatct ttatcactct gttcctttgc

961 cttggtggga aaagttgcag cttagtacca actgcctcct gcttgagcca ctgtgcacag

1021 ttactatcag cctggccctg taggcacgta gaacccctgg actcaatact gcataggatg

1081 ggataagacc acatctgatg tggtgaaggt caccgggatg atgttgtttc tgagataaca

1141 ggtatgtctg ccttccttcg ggttgcattt agctttcaca atcaacagtg ttgacatgaa

1201 gagcctgccg gactggacgg tgcaaaatgg gaagaacctg accctgcagt gcttcgcgga

1261 tgtcagcacc acctctcacg tcaagcctca gcaccagatg ctgttctata aggatgacgt

1321 gctgttttac aacatctcct ccatgaagag cacagagagt tattttattc ctgaagtccg

1381 gatctatgac tcagggacat ataaatgtac tgtgattgtg aacaacaaag agaaaaccac

1441 tgcagagtac cagctgttgg tggaaggtga gtccttggaa ctgagcacag gcaagcagat

1501 ggagcatagc acacagtggc gtgaataaca gctgtgaatg aatagtgaca ctggacttaa

1561 ctctccaccc atcaccctct cattcatctg cctggcattt tccttacctg aatacgtaag

1621 cactagacat attccccaat aggcaggccc ttccttcctt ccttccttcc ttccttcctt

1681 ccttccttcc ttccttcctt ccttccttcc ttcctttctt tctttgatgg agtctcactc

1741 tgtcacccag tctggagtgc agtgggtgat ctcggctcac tgcaacctct gcctcccagg

1801 ttcaagcgat tctcctgcct cagcctccca agtaattggg attacaggtg tgtgccacca

1861 cacctggcta attttgtatt tttagtagag atggggtttc actgtgttgg tcaggctggt

1921 ctcgaactct gacctcaagt gatccacctg cctcccaaaa tgcttcttca tctcgctcta

1981 taaattacaa tttctttctt caagactcaa ctcaatgatg ttttgccaaa acaaaatggg

2041 tctaccccag ggtgccagt^'c agtacagctc tgatgctctc tctacaggca atggtatttg

2101 tgtgtataaa ggccacagcg gtgtgttaag acacctcgtt ctgcagtcac tctgcctggg

2161 tttcaatctt gggtcaagtc cttaacatgc tctaaacttc aaaatcctca ccagtaaaag

2221 gaagataaca acgataccca tttcaggcaa ttattgagag ggttaaaagt gtcatgtggg

2281 tagagtgctt agcaaaattt ccagcaccta gtgagttcct aataaataga aatgtattta

2341 tttatttgag acagagtctt cctctgtcac ccaggctaaa gagcaatggc gcgaccttgg

2401 ctcactgcaa cctctgtctc ctgggttcaa gcgattctcc tgtctcagcc tcccaagaaa

2461 ctgggattac aggcacgcgc cactgtgcct ggctaatttt ttgtattttt agtaaggatg

2521 gggttttacc atgttggcca gcctggtctc gaactcctaa cttcaagtga tttacccacc

2581 ttggcctccc agagtgtcag gattacaggt gtgagccacc atgcccggtc cacaaatatt

2641 ctatttcact cagtattggc atccgttctt acacatctgt ctgctcttct ggatagtgaa

2701 attgtaaaga cagagatggt gtttgggttt attcttatat cttgaacaat gaatctggct

2761 catagtaggc attcagtcaa tgttcatgga ataaattaaa gtcagtccta gcctgtgggt

2821 gcattcaata aagggtaaca acaatcacag tgacactgac aaatactggg ttacctttcc

2881 cctctaagca tcatctgttg ggaatctgat tgtgtcctct tcccaatagg attataaacc

2941 attgaaaaca ccaagtacat cttgaccata ttttattttt taaatttatt tatttattta

3001 tttatttatt tttagacaga gtctcactct gttgcccagg ctggagggca gtggcacgat

3061 ctcagctcac tgcaacctct gccttcgggg ttcaagcaat tctcctgcct cagcctccaa

3121 gtagctggga ttacaggtgc ctgccaccat gccggctaat tttgatttaa tagagatggg

3181 gttcgccatg ttggccaggc tggtctcaaa ctcctgacct caggtgatcc acctgcctca

3241 gcctcccaaa gtgttgagat tacagatgtg agccacctcg cgtggcctta gtggtgattt

3301 tggtggaccc atcacccgag cagtgtacac tgtacccagt gtgtagtcat tttatccctc

3361 gctccctccc actctttccc ctgagtcccc aaagtccact gtatcattct tatgcctttg

3421 tttcctcata gcttagctcc cattgagcat attttatatt ttttcctttc ttttcttctc

3481 ttttttgaga cagggtctct gttgcccagg ctggagtgca gtggtgggat tactgctcac

3541 tgccgcctca acctcctagg ctcaagtgat tctcccacct cggcctccca agtagctggg

3601 actaccagtg cacaccacta actacccctg gctaatttta attttttttt ttgtagagat

3661 agcatttcac cgtgttgccc aggctggtct ccaactcctg ggctcaagag atccacccac

3721 ctcagcctcc agattttata tatttcaaag tgcctagtac tgtgctgggc acatacctgt

3781 tcatttatta cctggtaggt cgcactgggt gttcagagaa caaaaaagag ccctctcatg

3841 ggatcaacta cagtcactca gcggagggga gggcttgtgt ctctcaatca ggctgatact EPI-109 1050

3901 gacagacttt cttcttcaat caggctgata ctgacatgac tttctacttt ccccgtagga 3961 gtgcccagtc ccagggtgac actggacaag aaagaggcca tccaaggtgg gatcgtgagg 4021 gtcaactgtt ctgtcccaga ggaaaaggcc ccaatacact tcacaattga aaaacttgaa 4081 ctaaatgaaa aaatggtcaa gctgaaaaga gagaagaatt ctcgagacca gaattttgtg 4141 atactggaat tccccgttga ggaacaggac cgcgttttat ccttccgatg tcaagctagg 4201 atcatttctg ggatccatat gcagacctca gaatctacca agagtgaact ggtcaccgtg 4261 acgggtcagc atctgctccc ttcctcatcg ttctttgtgg tttctggt

1 gttctagaga agaaaggttg aattttaaag ttagttagga acaatagaaa agtttgaaaa 61 ggggaagcag caaaaagagc agaagaggct cctcttgccc aggtttgcac ctgagtccaa 121 ccaggttgtc ttcctctctt gcagaatcct tctctacacc caagttccac atcagcccca 181 ccggaatgat catggaagga gctcagctcc acattaagtg caccattcaa gtgactcacc 241 tggcccagga gtttccagaa atcataattc agaaggacaa ggcgattgtg gcccacaaca 301 gacatggcaa caaggctgtg tactcagtca tggccatggt ggagcacagt ggcaactaca 361 cgtgcaaagt ggagtccagc cgcatatcca aggtcagcag catcgtggtc aacataacag 421 gtagggctgc tgctgccgga gggtgttggc atatggcggg ctcaagaggc caccatgctg 481 caatccagca tggccaaaga gagctgatca tttcctgccc ctgcttatct gaatgaatgt 541 gctcagatgg ggctttggtg ctcgtgggag gaaaccactg cagagcgagt taacagtcta 601 ctgtgcgtgt tgagggtaca ggctccggca ccaaagctta accctgccgc tcactgcttc 661 tgtgaccttg ggtgagttat tgaacgtgcc gcagcgctgt gagatggtga taatgacctt 721 ttaggactgc tataatgatt aatgagataa ctatactgta agcatgagct gagagatttg 781 tacagagtaa gactctgaaa cactggttaa tgttttcatt actctgttat atttctccat 841 cccctgtgac aagcactatg ctagatc

1 gaattccggc ctgtgaatcc atctggttct tggacttttt ttggttggta agctattgat

61 tattgccaca atttcagatc ccgttattgg tctattcaga gattcaactt cttcctggtt

121 tagtcttggg agagtgtgtg tgttgaggaa tttatccatt tctcctagat tttctagttt

181 atttgcgtag aggtgtttgt agatattctc tgatggtagt ttgtatttgt gtgggatcgg

241 tgatgatatc ccctttatca ttttttattg cgtgtatttg attcttctct ctttttttct

301 ttattaggct tgctagcggt ctatcaattt tgttgatcct ttcaaaaaac cagctcctgg

361 attcattaat tttttgaagg gttttttgtg tctctatttc cttcagttct gctctgattt

421 tagttatttc ttgccttctg ctagcttaag gagtttcatt cttgttgccc aggctggagt

481 gcagtggagc aatctcggct cactgcaatc tctgtctcct gggttcaagg gattctcttg

541 cctcagcctc ccgagtatct gggattacag gcgcccacca ccatgctggc taattttata

601 tttttagtag agatggggtt tcaccatgtt gcccaggctg gtctcaactc ctgacctcag

661 gtgatccacc cacctctgcc tcccaaagtg ctgggattac aggcatgagc caccacacct

721 ggccacaagt tgcaaaactt ttctaatcct tgtcattgaa ataaattgga ttaacaagaa

781 aggaaaacct gccattggaa tcctaggcaa agaatgaacc ctagctcctt actggggtga

841 tcgttaggta catgagaagc aaaggaaaac tttttgctgg aagttggaag ttggttctgc

901 caagagcacc tgagccaagg gcctctccag gaagggtctt tagggtggtg gccagacaca

961 tctcgctcca ttcccactca ctgtttttca gaactatttt ccaagcccga actggaatct

1021 tccttcacac atctggacca aggtgaaaga ctgaacctgt cctgctccat cccaggagca

1081 cctccagcca acttcaccat ccagaaggaa gatacgattg tgtcacagac tcaagatttc

1141 accaagatag cctcaaagtc ggacagtggg acgtatatct gcactgcagg tattgacaaa

1201 gtggtcaaga aaagcaacac agtccagata gtcgtatgtg gtgagtatat tgttgcgact

1261 cagaggacat ccggggttga atgggagaaa ggaaatttat ctgcagctgc cgccctctcc

1321 ggtctccggt ctgagcagac tcaggcaggg taagaactag agggagagaa gtgcgaaatc

1381 aaaggccaaa gaaacaagga ggtattcctg ctcagaacac tgattcactg atgatgatgt

1441 ggcctctgac ttgcaagatt ctggcaagat tctgcctcct ggagcaagac ccacccaaaa

1501 gttcaggaag gaaacactac ttagtcaatg ttaaactttt cttttttttt tttgagacgt

1561 gtcgcccagg ctagagtgca gtggcacgat agctcactgc aacctctgcc tcctaggttc

1621 aagtgatctc ctgcctcagc ctcccaagta gctgggatta caggtgccca ccaccacgtc

1681 tgcctaattt ttgtattttt atttttatta cttttattta tttatttatt tatttttttt

1741 cggtctgtca cccaggctgg cagtgccagt ggcacaatct gggcatcact ggaaagcatc

1801 cgcactcctg ggtacacgag cattctcctg cctcagccct cccaagtggg tgtggactac

1861 aggacacacc gt

1 tcacttgagt ccaggagttc aagaccagcc tgagcacata gtgagaccct gtctctacaa

61 aaaataaaga attagccagg tgtggtgtgc acctatagtc ccagctactc gggaggctga

121 ggtaggagga ttgcttgatt ctgggaggtt gtagtgagct gtcatcgcac cagtgcactc

181 cagcctgggt aatagagtga gaccctgtct caaatacaca cacacacaca cacacacaca

241 cattttgttg gctacttgtt gtactttttc tatgttttct gtgtctttgc tcaacacaag

301 aaaagtatat tatgtgtgca tgtgcgtgtg agatatggta aaatatgaac atgtatttct

361 ggggatgtaa tgttttcctt gaatttctgt cattctctgt tttgcttatt gtacttctct

421 ttccctttcc cttctcacca cacacacaca cacacacaca cacacacaca cacagcctgt

481 cagtctcata ggtgtcctat aaaggtaaat ggcaggcagg catttgaaat tacagcaggg

541 atagaaagca aaactcaggc tttggaggag gaacctcttg tgctggatgc tttgttttta

601 ccttcagtgc cttttggatt gtttctccct ctgttctaga aatgctctcc cagcccagga

661 ^■ tttcttatga tgcccagttt gaggtcataa aaggacagac catcgaagtc cgttgcgaat

721 cgatcagtgg aactttgcct atttcttacc aacttttaaa aacaagtaaa gttttggaga

781 atagtaccaa gaactcaaat gatcctgcgg tattcaaaga caaccccact gaagacgtcg

841 aataccagtg tgttgcagat aattgccatt cccacgccaa aatgttaagt gaggttctga

901 gggtgaaggt gataggtaag ttgctgtgct gtgagaagaa atcatgtggg cttggggcat

961 tctttcaccc ccagggactg tggggacaat aagagaagta gggggccagg tgcggtggct

1021 catgcctgta atcccagcac tttaggaggc caaggccggt gaatcattga ggccaggagt

1081 tcaagaccag cctggccaac atggtgaaac cccatctcta ctaaaaatac aaaaattagc

1141 tgggcatgat ggcgtgcgcc tataatccca gccactcggg aggctgaggc aggagaattg

1201 cttgaaccca ggaagcacag gttgcactga gccaagttgc gccattgcac tccagcctga EPI-109 1051

1261 gcaacaagag cgaaactcca tctaaaaaaa aaaaagcgag agaagtagtg ggtgcttatg 1321 caaagtccat atactagata tgcaccaaag cagggccaag gttcagtaaa ggaggctgga 1381 aaatatttgg gggctattga tgaggacaat ataatctctt tccagaacct ttcaacaaac 1441 tgctaaaaga tgataagcat gaaagtgtcc tgactgcagg aagcactgaa gttgtgcata 1501 tgggcttccc ttagcacttt ctccttttca gatacactgt tctgagaatt gtagatcagg 1561 actctgctgt tgtgactcct agccggggaa ccctgccttg tgtgaattcg agattagcct 1621 ggccaacatg gtgaaatcct gtctctaata aaaatacaaa aaattagctg ggtgtggtgg 1681 tgggcacctt taatgccagc tactcgggag gctgaggcac aagaatcatt tgaacctggg 1741 aggcagaggc tgcagtgagc caatatcatt ccgctacact ccagcctggg caacggagca 1801 agactccatc tcaaaaaaaa aaaaaattaa cattacatag actaagcacc taatggtgtg 1861 aggcatacaa aaaagaagac atattctttg tttcaatgct gtggtaagaa acacaagctc 1921 tcctaatgaa aatgatggac aaacatctga atcatactac caataagcat agaaaaaatg 1981 ttgggggtca tgtttggttg tcacgtgaac tatatcctta cagtgatggt gatagtaatt 2041 tagggtatgc cagacttcat ctagcttaag tgggtaaaca ttgtgaaaaa gctgggctag 2101 gtgccagggc ttgagaatgg gtggccagag aaggctgaag atggctgaac atctccagca 2161 aacacatgag ccaaaaggtc ccatggggca cttcaaaaga ctgtgcgcag ccaggtgcgg 2221 tggctcacgc ctataatccc agcactttgg gagaccgaat ggggtggatc acttgagccc 2281 agaggtttgt gactagcttg gccaacatgg caaaaccccg tctctactaa aaatacaaaa 2341 attagcccag cgtggtggtg ggtgtcctgt agccccagct actcaggtgg ctgaggtggt 2401 agaatcactt gaatccagga ggcagaggtt gcagtgagcc aagatcgtgc cactgcactc 2461 cagcctgggt gacagagtga gactctatct ccacaaaaaa aaaaaaaaaa aaaaaaatta 2521 aaggactgtg gccaaatcag atggctggaa acaaaggctg gagtttggga atggagaatc 2581 accggatatg agctgaaaaa gtggctgagc ctaagcgtga caggtgtcag gtgccagtct 2641 caggagtagg caattgtcct gcatgcagtg aaaagccaga agatggaagg aaggacagga 2701 tgcaaatgag ttctcggaac gatccacctg gtggctgggt cagggagcag gcatggtgac 2761 ttcagacctc atggtacgtt agaggctaat gtgaagccca tgtgaagctg ttggtttaaa 2821 ctgggtcgat atcagtggca cacatttact gaccatgtgt ccagccctgt gtgaagtact 2881 gtagtaaatt gctccaatgg aaactcacaa taaccacaga aggccagtaa cagcattgtc 2941 gttattttat catgacgcaa ctgaggctta gggcagacag ctggtgggtg gtgggactgg 3001 gatttgagcc cactggtgtc ccaggcccgg agcttggctt cttccattgt cttaccacag 3061 cctgcactca caggagagtg actcataagt tacaatacca tctgctgacc atctgctctc 3121 acactagaag gaaagtctac ttggggagac aatttaggat ccgaattttg gtagttgagg 3181 atggagctag gaaaagcgga tacaggaggt agccaagttc tgcttggacc tgcagggagt 3241 gaggctggcc gggctccagg tggaaatccc caggtgaaaa gggagacttg gagttcagga 3301 aagtaacctg gactggagcc ataggtttag gtgtcagtgg ctcagagaca gaagctcagc 3361 gtgtaggtga aatcacccag gaggagaatg gggatggaaa actgaggatt gaattttgca 3421 aaatgttcat acttccgggg aaaacaaaga ataaccagtg aataagaaag gggtgccagg 3481 taagaaggga agagaatcag agtcatgagg aaccccagaa ccccagaaaa agctgagttc 3541 cacgtaagac ctgggcaaca gtgaagtatg gagagcccaa gattgggagc gtggaggaag 3601 agcatccacc actgaattta atcagccccg gactcaggga cgttggttgg ggaatcaagt 3661 gaccttccca gtttcttcaa aacttgagag agagtgcagt gtcacaagat tgtgactaca 3721 aaagagtgca gtcagatttc aggggtaaca agaaagtgtg aaataaggga gtcaaagcat 3781 aaaggaaaaa ggagaaaaaa tggccgatag ctagagaagg cgtgggtcaa gattgtctgt 3841 ggcctggcat ggtggcttat gcctgtaatc ccagcatttt ggaaggccga ggtgggcaaa 3901 tcacctgagg tcaggaattc aagaccagcc tggccaacag ggcaaaaccc cgtctctaaa 3961 acaacaacaa caacaaaaaa atccaaaaag ttagctgggc ctggtgggcg cacctgtcat 4021 tccagctact cgggaggctg aggcaggaga tttgcttgaa cccaggaggc acacgttgcg 4081 gtaagctgag attataccac tgcactccag cctgggtgat aagagcggga ctctgtctca 4141 gaggaaaaaa aaaaaagttg agcagtggct gtctcatgtt cctcttcctc tgcccttctt 4201 tgctcagtgt gaatcctttt cctgcttttc agccccggtg gatgaggtcc agatttctat 4261 cctgtcaagt aaggtggtgg agtctggaga ggacattgtg ctgcaatgtg ctgtgaatga 4321 aggatctggt cccatcacct ataagtttta cagagaaaaa gagggcaaac ccttctatca 4381 aatgacctca aatgccaccc aggcattttg gaccaagcag aaggctaaca aggaacagga 4441 gggagagtat tactgcacag ccttcaacag agccaaccac gcctccagtg tccccagaag 4501 caaaatactg acagtcagag gtgagtcagg gtctccatag caagctgtgc tgtgggcccc 4561 caagggcaag accagaaaac accccccttg taagagggag tttgggggga gtctagctta 4621 tgtgactgaa ggctaggaga gtaatgtcct ccaggctctt ggttgcaagt gacagaaacc 4681 cactcaaatt aagtaaaaaa gagaaatcga ttattataag gaattgggag aatgtcacat 4741 cgttccaatt acaaattgtt ggcagactca ccattgagtc atcttgggtc aaacatccaa 4801 ccacagacca cctgtagcca aggggattgg gtcacgcaga acagacatga ttggggaacc 4861 acttatgtgg gtgtgggggc ggtttcctgg agaagaagag ggctgaaaac acatgccaaa 4921 aaggagtcta ctccacttga gccctggagt tggagaccag cctgggcaac atggtgaaac 4981 cctgtctcta caaaaagtac aaaaataggc tgggcgcagt ggctcatacc tgtaatccca 5041 gctactcggg aggctgagac atgagaatca cttgaaccca ggaggtagag gttgcagtga 5101 gcagagcttg ctccactgca ctccagcctg ggcaacagag caagactctg cctcaaaaat 5161 caaaccaaca aaaaatagct gtgtgtggtg gtgtgctcct gtagtcccag ctactcggga 5221 ggctgaggtg gaaggattgc tcaagcccag gaagttgagg ctgcagtgag ctgtcatcag 5281 cctctagcct gggtgacaga gtgagaccct gttcaaaaag aaagaaaaag aaaagagtct 5341 acccagcaaa gctggtttgt tccctccttg aggaccacag ctgacctcta tttgtagcag 5401 aaacaatcat ttctgcacca gctctgagtg cagaacccct cagaggtaga tggatgctaa 5461 ggcaagctgc cagttacaag agctgtgaga atcagactga cttttgttgc ttaaggcctg 5521 atattatttc ttcctggcag aggaagagcc tatatacaaa aaaaattttt tgttttgttt 5581 tgttttcagt cattcttgcc ccatggaaga aaggacttat tgcagtggtt atcatcggag 5641 tgatcattgc tctcttgatc attgcggcca aatgttattt tctgaggaaa gccaagggtg 5701 agcatagttc tttccttcca tactgactgg tcgtccttgc caggaaacca gccagggatg EPI-109 1052

5761 cgtggtgctt ttctgacccc tggattcagc taggcaaaaa tgaaagctat tattttcctc

5821 attgggcaaa ccagaaaaga taaaatttgg gggaaattac atctttgtgt ggttagaaga

5881 agccatttct gtagatttgt ccacacctag tcctgtaatg cgtgtagagt ggggtgcaag

5941 cgtcttggag acacacaaac atgcgcataa cacccacatg ttgcacacac acattg 1 acctctttct tttctgtctt ttgaaaaaga gtgaatatat ttgccttctt tttctctctt

61 tttctgggta ttcaatcttc tgggaagtcc aaacgtagct gaaaagagtg ttccttcaca

121 gcttactagg agtaaaacaa aaagaaaaga aaagtgtttt ctatctatta ggttagtgca

181 aaagccattg gcgttttggc cattatagtg gtatggatgt gggtactgta tactgacttt

241 ggtttttcgt tttctgtttt taaagccaag cagatgccag tggaaatgtc caggtgagtg

301 tatttgtaag aagggggcgg ctgctctgtg agcacggtgg acatgtctgg agggagattc

361 tggtcattag gaagttttca gtggctcttg gcaaacttag aaaaatatag gccttccttg

421 ggtgtgagtt gtgtgtgtga gttgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtatctc

481 cgtggaagaa tgccaattgt cctttcatgg gaaggaatgg cttttattct gagatcatgt

541 ccttcctaca tgattatttg tgaaatctcc ctttctttat gaaattataa tggtagtaga

601 taatttttta aaatttgaca aaatagagtt ggcctttaaa aaatggtttt actaccttta

661 ctgttgttga aatcccaaat caaaagtata gaaatgattg ctctgttcca gagagaaaca

721 gtagcgtggg ataagaattt cagggggctt ggtagtagcc tgtgaaggac tccggtattc

781 atgtgtgctt tggtctgatg ttatttaata ggaaagtt 1 aaaaaaaaaa aaagtttttt tacataatcc ttggagctgc caaaaaatat ttgttttcca

61 aatgagagag taaagttttc cttaccttgg aaaactcttc ctggttttct catgatcttc

121 ccttgtttac tttggtggtt tggggttaga acaataacaa caacaaatat atctatatat

181 tgttttctgt ttttatattt cattttaaag gccagcagta ccacttctga actccaacaa

241 cgagaaaatg tcagatccca atatggaagc taacagtcat tacggtaaag tcatgttctc

301 ctgccattta taattccccc caacttgcta catacttcct tacccctctc agaagcagaa

361 tatgtaagtg gtgggattac agttggaaga gaaaccctgg cttcaacagg gtacttcatc

421 tcatcagcca ctgggccatg taatatacgg aaacgtaaaa ggaaaggtaa catattttat

481 tctaactttg ccaccttcca aactccccgt agaagaaaga tggagaataa tcataatgcc

541 ttcaaagact ttgaacattg ctccagcgta atattataat tctccatttt caagacagag

601 acagatattg aatgaaacat tggtaaacat cttctcagat ggaattatta caagcacaag

661 acagttttac ttcaaatttg gcacaaaggg aaagcaattt caatattctc tcagtaaagg

721 cataaataaa gtgttccaac taagaaaata tctattcata aggctcatca gtagcttcag

781 ggtcagctca gctgaatgag taggcagtcc taggagttct taatcccagg ttagtaagaa

841 aattgctcaa gcatttcagc aggatgctac ttacttccca gaggggggta ttattacatc

901 acaaaaagtc ctgtcccaga ccaaatttgg ggacactctt cctctt 1 atagccacga ctcaaatata ttgatcttag aatctaaaag acttaggtct gggcgcggtg

61 gctcacgcct gtaatctcaa cactttggga ggccgaggta ggtggatcac ttgaggtcag

121 cagttcaaaa accacctggc caacatggtg taaccctgtt tctactaaaa atacaaaaaa

181 ttagctgggc atggtggtag atgtttataa tcccagctac tcaggcaggc tgaggcagga

241 gaataccctt gaacctggga ggtggaggtt gcatgacctg a

1 tggacctcaa catgcacacc agtccgagca acaagagcga aactccatct caaaaaagaa

61 agaaagaaag aaactatatt caggccaggc atggtagttc atgcctataa ccccagctct

121 ttgggaggct gaggtgggag gatcattgag cccaggagtt ggagaccagc ctgtgcaaca

181 aagcgagaca tggagaatgt ggaacgaggg acccaggacc cagagacagt gctggttgtc

241 actacactga ataaatcagg cttgactttg ttaggggtac tgaattttta aaagggtttt

301 agaaaactag aatttccctt gtcactcacc ctaattgtta tttttcaact aggtcacaat

361 gacgatgtca gaaaccatgc aatgaaacca ataaatgata ataaaggtaa ttatctaatt

421 acatgttttt attagaacca acttttacat taaaaaaaag actcatagga aaagaaaact

481 aaaacttgaa ggactgtgga taatttccca cctctcttaa tgaccctgta cccagccgat

541 gtgtcaatga aggtagctag ctgctttcac cagagatgct atctagtgtc ctcagtggga

601 agtacctaaa tcaaagtagg gaagaactgg gttatactca aaaaa

1 acaacaactc tgtggtttct ttaggcagag cctctgaact cagacgtgca gtacacggaa

61 gttcaagtgt cctcagctga gtctcacaaa ggtaagtgcc actcgagtga gtccccaggc

121 attcgctttg gcttgggttt aaaccccagt ggtggcgggg gtgctgtgtt cagtgagaag

181 agtctgtgca ccctcagtcg ctccaaagga agtgattagc agacctaccg gcctgctaag

241 actggaagga gcaaggcccc tggcctggcc tgtctctgag ctgtaaaatt tcaataattt

301 aaaagaaaaa aagaaaaggc caggcactgt ggctcacacc tgtaatccta gcactttggg

361 aggccaaggc gggtggatca cctgagatca 1 tatattttat atattaatat ataaatataa atacatatat aatatataat atatgttttc

61 tttgtgtata atatatattt tataatattt tatatatttt tattttttat ttttatatat

121 tttatatata atatttttat atttatatta tttatatatt ttttatttta tatatatata

181 tatatttttt tttttctttg ttgagacgga gtctactctc tgcccaggct ggggtgcagt

241 tgcgagatct

1 tgcaaacctc tgcctccggg ttaaagcagc attctcctcc ctcagcctcc cgagtagctg

61 ggattacagg catgtcaccg ccacagccgg gtaatttatt tatttttttt ttgtattttt

121 aagtagagat gggatttcac catgttggcc agcgtgaact cgaacttctg acttcaaaag

181 atccaccccc ctcagcctcc caaagtgctg ggattacagg tgtgag

1 gaattcaatt tgagttttcc agacccgtcc tcctccttgg cagctaagga gcagtgtggg

61 aagtcaggcc tgagcctcag gtgttccctc tctgccttcc tgtgggtgga gagccaggta

121 ttaccaggta cgaaaagggg ctttgtgggt acaaggctca gtggtgagta catttgacct

181 ggtcttgacc aagccagttc cctgctctca agacttcctc ctcctatgga ggaggggttg

241 ggaaccacat ccagctctga ccctagtggc aggcgaccaa gtggtcactt ggggtggagg

301 aggggcagga aggaactcag taaatcctgg tttgctgcat gtttgctctg agactaattg

361 ctgggaaaac cccatgacgt tggaagccat ctccttctct gttatcacag agaaaaacag

421 aagccaaaat aaagccccat ccggaaacat ccctgacagc agagacaaag agcctgccag

481 cctggtttac tcattagcaa gcagctgctc cctggagtgg gtggggagga gaggtagtga EPI-109 1053

541 tgagctgcaa ctctgcctgc ccacccatca cttaactggg cagatttggg ggcagctgca

601 actctagaag ctccaccaag aagcagaacc ccccaggccc aaacaccaag ccctctccct

661 ccatttattc ctcacctgcc ccagccccca ctgtgggcct gggtgggagg gtgagctggc

721 cgtgaccacc ccaccatgcg cctggtatat ggtgtttgat agcatttgtt gcagtgtctg

781 cgttgtttgt gcacctgtct gcctcacagc ctggagctcc tgaaagctgg ggaccaggcc

841 cgatcacctt tcctcttcca cagtgcgggg ttcacactag gtgtctagga ttctgctgag

901 tgagtgattt ggccaggcct gacatcaagc agagggtgtc ttggggatgt ggaggatccc

961 ccaatagggt tggggatccc tacagcttcc cttgagggcc ccacatctgg tgccacagaa

1021 agagagtgag gggtgtgtgg gcatctctgc tgtcccagca gtgtggtgcc ctggtagctc

1081 agccactcta ctgagttcca aatcctgttt gggtgccctg ggggaagtca gtgtaagggc

1141 ctagtca

1 aaggagggaa atccacttga ccatggcaca ggaacccccc ttacccaatc tgggccttcc

61 ctttccccca tctgtaaaag gagaacagtg cccacacgac atcagcctct tttcctacag

121 tgagccttcc tggccctttg tgcagtagac aggagctggg aagtgcccag gttccatcct

181 gtttcctcag ggttggtggg tatgtatgtg tgtgcacacc ctgtgtgcat gagtgtgtgc

241 acacccagat tgcatgtttg tacatacagt gtgtatacaa tgtgtgtaga cacatcctat

301 acactgtatg agggtataca tagcatgtat acacattgtg tgcatgagtg tgcgtgtgta

361 tatgctgtgt gtgtattttt gtatacacat cctgtgccca taccccagtg taaggtaaac

421 agatggcagg aagggcgccc ttgagtctcc tccaggtata cgccacaccc tgggtcagtc

481 atcatgctgc catattgaga gggtctagcc cagaggatct cagccctgtc tgcatattag

541 ggcccctgag gagatcctaa aaaaccagca ccagggaccc ccccagacca atccaaccag

601 aagctgcagt gaggcccagg agccagcagt gaaaacagcc agcccagctg tctatctctg

661 taagagttct cagtcccagc tattcctagg gtcactgaca acccccaggc tctaacccag

721 acctcaggat cttgttctgg atcccggggt ctgggctctc aggtgattgg gaggccatag

781 cccaaccctg cgttgaggga cctggcagaa tgtctggaca agggtcacgg tggcagggga

841 agaggagtgg gggcagcaag ctggaggctg caggcccttg ctggggggct ctccatccgt

901 gggcccctca ggtccagggg ttcctctggt gcatgtggcc ctgctccaca atggcctgct

961 gacctcctat tcccagactg ggagtgacgc tcgttagacc aagacctcct tcttcttctt

1021 cttttttttt tttgggaggt ggtgtgtcac tgtgttgccc aggctggagt gcagtggcgc

1081 aatcttggct cactgcaacc tctgcatcct gggttcaagc gattctcgtc ccttagctct

1141 cgagtaactg ggatcacagg gacgcaccac catgcccggt taattttttg gaatttttag

1201 tagagacggg gtttcggcat gttggccaga atggtctcaa cctcctgacc tcaagtgatc

1261 ttgccccctc aacctcccaa agtgctggga ttacaggtat gagccacctt gcccagccag

1321 gatcttctaa catcagaaat gacaaggtct ctgggtgctt ctggacctgg ttctggtggg

1381 gtgcagtggt ggggtacagc cttgcctgca gagcctcaga ccttttccta tgactgcagt

1441 ggactgacct cgttcccaga ggcagctact aacttatgcc tggtcctttt tccagatcta

1501 ggaaagaagg acacagagac agtgtacagt gaagtccgga aagctgtccc tggtgagtga

1561 gggtctccag tgccccagcc tgggggatgc cccctataat cactgatggg ggcttgggag

1621 tgggcagaga aaagaagaag caaagaaggg caaaaaaggg gtggcacctc ttacaccagc

1681 gctgtgggct tcctctctcc caccaccctt aaaaagtcac ctcgggtcac atttactatt

1741 catgtagtca acgagcgctt cttgaatgct tactgacccc agccggtgac ccttacctgc

1801 tccccacaca ggccctggtg gctggggttc cccaaggtct tggacgtcga gtgttttgct

1861 ttggagaccc ccagtagctt cagcctttct tcttgttttc ttttttctct tttttttttg

1921 gggatacgga gtctcgctct gtcactcagg ctggagtgca gtggtgcaat ctcgactcac

1981 tgcaacctcc acttcccgga tttaagtgat tctcctgcct cagcctccca agtagatggg

2041 attacaggcg cctgtcacca cactcagcta attttttttt tttatatttg ggagacagag

2101 tttcgctctt gatgcccagg ctggggtgca atggag

1 tgctgggatt accaagtgtg accccccgcc ccagcagctt cagcttttct gacaagaaga

61 ctgactttgg gagtgggtgt gggtttgcgg atctactcta tttcctttgg ttcggctgcc

121 cccacttcgc ttcccgtgac gacccactgc ttactcatga aagggcttcc cccagagctg

181 agcacagagc ttaagcagac ccggaactgg gggagctcaa caagtccttt ttttcggtgg

241 gggggtataa taactgtatt caattcaggt gaaatgaaat acacaatgac aacttttaaa

301 ttctgaaggt aagtcagcaa tccgaaagac gtaaacattg tgggggaaat agtgactgtg

361 tgagtatctc gctttgtaca gcagacctct atttaagtgg gttcttggaa agggaatcat

421 taaaatggtc caggacattt ctgcaaaggg tgcctactca gcctaggcgt ggtggctcat

481 taagcactca gtaagtgctt tatttattta ccccaaataa ataaataaat ataaaaggat

541 gactcctccg agtacagtcg ccaaaccagc agcagcaatc tcgggcccag cccagaccca

601 caaaactagt ctctggaatc tgaacttagc cagcttcaga tgtttctgat gctgccaata

661 tttgagaagc actgtttgtg ttttgttttg tttttttgtt tgaaacagag tctcactctg

721 tcacccagac tggagtacag cagtgccatc tcagctgact gcaactccgt gcaacacccc

781 ccagccccta aggcttaagc gatcctccca agtagctaga accacagaca cacaccacca

841 tgcccagcta agtttttgta tttttggtag agatgaggtt ttaccatgtt gcccagactg

901 gtgttgaatt cctgagctca agcaatccac ccccttcggc ctcccaaagt gctgggatta

961 caagcgtgag ccactgtgcc aggcaaaaag cactgtttta gaagaaccat ccaattctct

1021 gaggaccctg ctttttatct gaaatagcga tcacttctta attcactttt aaaagttggt

1081 atatctacaa gaagaataga aactcaaccc ttgtggaact tgaccctgaa taatttttga

1141 aaaaccaatt ctctggggaa tttttagctc aaatacctca ttt

1 aaaaaaaaaa aaaaaaagaa gaagtagttt ctgcttttag tcagataaac aagctctggg

61 gagacttcct tctacatctg aaccagctca aaacaatcct tatgccaaag gggcatattt

121 tgtggtggca tattctgatt tccttcatct gctttagggc agctggctgt tcaagtgggt

181 tctctcgggg tctccaggtt ggttctaga

1 ctttctttct ttcctttctt tttttttttt ttgagacagg gtcttcgctc tgtcacccag

61 gctggagtgc agtggcgcga tcgcagctca ctgcaacctc cagctcccgg gttcaagtga

121 ttcttctgcc tcagcctcct gagtagctgg gaccacagct actgccacca cccccgggta

181 attttttttg tatttttagt agagacggtg tttcaccata ttggtcaggc tgatctcgaa EPI-109 1054

241 ctccagacct caggtgatcc acctgccttg gcctcccaaa gtgctgggat aacaggtgtg 301 agacaccacg cccggccaga tcatat

1 gatcctatct acgggaaaca tgaagagtaa tattctactg tggcctgggt gaccctgggc

61 aagtcataga gcctctcaag accttggtca ccttctctgt gagatgaggt atgggctgga 121 ggcaggtcag tggtcctcgg gctttattaa aacatcaata gtttggcgca ccccactccc 181 tgtgaatttc ccattcacta ggtctggagc ggtgccgaaa acgtgcattt ctaacaggtg 241 tccacacgca gctgctcgcc gacacgctgg ggcccgggct ttgagaacca ctcttgatgc 301 agcatgttcc tttctgattg tgccacgcta aggctctgct tcttgttgga aggagtaggg

361 tctttctcac ccccttccccaaggaaaaaa tcctggaggg atctttcagc attggtgggc aggtaaaacc 421 cagaaacact ggttggccttttaattttaa ggaaggggggaaaaggggtt tgtattgagt gacccccaat aaaacagggg

481 gcccagggcc gcgcgcagtg gctcacgcct gtaatcccag caatttggga ggctaaggcg 541 ggcggatcat gaggtcagga gatcgagacc atcctggcta acacggtgga aaccccatct 601 ctactaaaaa tacaaaaaat tagctggacg tggt 1 agataagcaa tagggcatgg gcaggcctgc ctccaaggag cagccccagg gccgaggaga

61 gagagctggc gctggcccag gggacttgag tttgatggga aagcttgcag acagtggggg 121 agctgcctgg tctttccagt cttggctttt ggctctaagc acagcttttt tttttttttt 181 tttaattgtt gtatcatgag gcgccttcca ctcagctgcc tccccacgtt aggggatgga 241 cacagcactg gcagggatcc tgtgtgtctc agtttcccta ttgactctct gtggcctaga 301 gatgtatggt agaattccac actatgcttt ttttccaccg tgtttttttt tttttttttt 361 tttgagacag ggtctctctc tgtcacccag gctggagtgc agtggcgcaa tcttggctca 421 ctgcaacctc cacctcccca ggcaggcccc tctgactcag ctgggactac aggcatgcac 481 caccagcacc cagcaaaata tttttatatt ttagtagaga tggggtttcg tcacattggc 541 caggctggtc ttgaactcca gagctcaagc aatccgcccg cctcagcctc ccaaagtgct 601 gggattacaa tgcccagccc actttttttt ttacttttta caattttatt cttaaaattg 661 tggtaaaaca catatcacat aaaatttacc attttaactc taagtatcca gctcagtggc 721 actaagacta cacttttggt tgtcatagcg tggtgaacag agaagagaat gctactgcgt 781 ctcgtggaga gaggccaggg gataccgcta aacatgcgac aatgcacagg acagtcccct 841 ccccaccaca aaacaccacc cagcccaaaa tttcaacagg gccaccatgg agaaaccctg 901 gccagaggaa ttcacctcct gcaactcctc caacaggaga gctggttttc ctctccagta 961 ccagcttgtg gctgccctct gtcttgggag ggtgacttaa gggcacatcc cacctgatta 1021 ctgtgggctc tggatgggtg ctgagtcttg gtctggggaa cag 1 aaattaccca ggcatggtgg tgtgcgcctg tagtcccacc aacttgggag gctgaggcag

61 gagaattcct tgaatctggg aggcggaggg tgcagtgagc cgagatagtg ccagctgagg

121 caggagaatt ccctggaggt agaggttacg gtgagccaag atggcgccac cacactccag

181 cctgagtgac aaagcgagac tctgtctcaa aaaaaaaaaa ataaagaaaa ttttaaatga

241 agtgccaggg actttatgcg catgtcatgt ggagctagct acagggtccc ggggaagctg

301 tcttgcacaa aggagccata aacctctaag ggcactgccg gctgatgtct cctggctctc

361 gcctcctccc tcttttctcg acctgctcct gaccctgtga tgttgttggg gcagttgaac

421 tgggttattt gcgttgctca ctgccatgtc atcctttgtt ttgtagatgc cgtggaaagc

481 agatactctg taagtacaca tttcatatac attatattta aaagtactcc actgaacagt

541 gaaatatttc cagactcacc cacgcctgca ttcacacgaa ttcttccccg ctccctagcc

601 tgttcagacc agaagccctg ggcttctctg actagccttg gccagttctg atttcgaata

661 ttctctcctg caatttccat cattacatct cagcccacac gtgaagggat tgggactctg

721 gggtgcttag cgccaaacaa gcaaagcaca catttcgttt aacgccaaag tctaggctct

781 ggaagtgagg cagatctagg gtgtatgctt ggaggagtgg agcagctgac agctcattgc

841 aatttagccg atactaatta ccccctacac accaggccat cagctgcagg aggacaccca

901 agcttcttga cctcagttca ccttctgatg agggaatcag acatgtgatc acttatcata

961 aagccaagtg agctatgcca gagcctatgg gaacacagaa cagagaccta gctagtgccc

1021 tcttccccaa ggaatcattt ggaatggccc atgaagaatg aatggagtga tgatgccagc

1081 attgagggag aaagatcagc aggagcacaa gggtgaggga tgaccagttt caagcagtgt

1141 gggatgggaa agaagagtgt gacagtgaca agtgacggga gaaagataag tcagggctta

1201 aatccaaagg atttacatcc cttgttaaga agcttcattc tgtaggaaat ggagttagga

1261 atctgcattt ggcagatggg agggtttatg aaagacacag aggcccacgt tcaacttttg

1321 caaagacgtg tcttccaatc ccaacctttt tgtgagctac ccagcaatgc aggagttaac

1381 tgggcagcta atatctgaag aaatgaggca tttgccgcat aaacttcttt taggtctggg

1441 aagaactttc agcaaagatt tcaggtagct cttccagtgg cccctggctt cctttgtttt

1501 gcccatgtca ggactcttgt aaaacagagc tc

1 gagctccagc tttccagctg tcttttgggt gagcctgtct tcctcaagct caagcttcct

61 tatctataaa gtggagatgg tgatgacaat gatgataaga gcaacctatt aggattttaa 121 ggatgaaatg agcaactgca accaccatat aaaagctgca agctgcaaac caccatataa 181 aagctggttg aattccttccaaaaggcctt ccttttttttccaattccaa cttgggcaat agtaggtgtg gatgggggac 241 ttaacttgat ttttggggccccaattggaa aaaattggaaccccccttgg ccacatatgg agaatgtagc agttgcttac 301 ccaaggcata ggattcaacc aaggccaggc tttgacttag gaatcagaga cccacattaa 361 catttgactt cccgcttctt agccatgtca ccatgggcaa atttcttggc ctctcaagac 421 ctctgcttcc taatctgtaa actgggaatc ataaactccc tcacttggtt gttgcaaggg 481 ttgaatgagc ac 1 ctatcaatct ccagagcttt ttctttttaa gtgtgagcga gtttattaga gaagtaaaga

61 gacccaagag tgcctactcc atagacagag cagccactgt gacactgtac ccattaaaca 121 ctaactctcc attgcccctc cagcaacccc tagcacccac tgtctacttt ctgtctctat 181 gtggttgtct atttgaggga catcacataa gtggagtcat atatttgtcc tttcatgtct 241 cccttatttc atttagcata acgttttcaa gggtttcctg tgttgtgaat atatcagaat 301 ttcattctct ttttaaggta gaatcatatc attttaaaac atttcagttg gaccatctaa 361 gttcagtcct tcattttcaa caattaaaaa acagccctca accgggtgca tctcacgtta 421 gctagagaca gaactggagc tagaagtcag atctcttacc aaagttgcct ttcttcttct 481 gtgggtaagt ggggcaccct tgggacgctg tgctgggcgt acatgggtgc ttgatgaagt EPI-109 1055

541 tacttggtgg actgatgtga ttgatgtcca acatgtatgc agggacagag gctatggtcc

601 ctacagagca ggcatggaga gaaggagaaa tacatacggg caggagccag gagagggagg

661 gtgtagtgag cagagaccgc gccactgcac tccagcctga gtgacagagt gagaatccat

721 ctaaaaaatt gcttactaaa gaagtggtct cctgaggtct taagacgttc ctggcaatgt

781 cttgagtggg tgggagagag cctccagtca ttgagctgtg gaatttcaga ggtgagaacc

841 acacctaacc cccaattact ttcccctgtt tgcctcagtg acacagctgc aggaaccctg

901 gtgggtgttg tattaagtaa atttgacctt tattctttgc agatctgtga aatgttgtct

961 tctgaggggc cacgtgtatc tgtagtgctg aggactcctt ggggcctctg aagtcacaga

1021 gagaacctgc agggtggggg accagtgtgt gacagccctg ctttgcattt tctttgagaa

1081 gtgctgtcat tttgcatttc tctccaccag gggaatcttc aatcttgaga ggtgtgatca

1141 taacttgcct tgtttcttgt cgctacagag aacggaaggc tcccttgatg gaacttagac

1201 agcaaggcca gatgcacatc cctggaagga catccatgtt ccgagaagaa cagatgatcc

1261 ctgtatttca agacctctgt gcacttattt atgaacctgc cctgctccca cagaacacag

1321 caattcctca ggctaagctg ccggttctta aatccatcct gctaagttaa tgttgggtag

1381 aaagagatac agaggggctg ttgaatttcc cacataccct ccttccacca agttggaaca

1441 tccttggaaa ttgggaagag cacaagagga gatccagggc aaggccattg ggatattctg

1501 aaacttgaat attttgtttt gtgcagagat aaagaccttt tccatgcacc ctcatacaca

1561 gaaaccaatt ttctttttta tactcaatca tttctagcgc atggcctggt tagaggctgg

1621 ttttttctct tttcctttgg tccttcaaag gcttgtagtt ttgggtagtc cttgttcttt

1681 ggaaatacac agtgctgacc agacagcctc cccctgtccc ctctatgacc tcgccctcca

1741 caaatgggaa aaccagacta cttgggagca ccgcctgtga aataccaacc tgaagacacg

1801 gttcattcag gcaacgcaca aaacagaaaa tgaaggtgga acaagcacat atgttcttca

1861 actgtttttg tctacactct ttctcttttc ctctacatgc tgaaggctga aagacaggaa

1921 agatggtgcc atcagcaaat attattctta attgaaaact tgaaatgtgt atgtttctta

1981 ctaattttta aaaatgtatt ccttgccagg gcaggcaagg tcgtcacgcc tgtaatccca

2041 gcacttcagg aggctgaggt gggcggatc

1 gaattccggg agaagtgacc agagcaattt ctgcttttca cagggcgggt ttctcaacgg

61 tgacttgtgg gcagtgcctt ctgctgagcg agtcatggcc cgaaggcaga actaactgtg

121 cctgcagtct tcactctcag gatgcagccg aggtgggccc aaggggccac gatgtggctt

181 ggagtcctgc tgacccttct gctctgttca agccttgagg gtcaagaaaa ctctttcaca

241 atcaacagtg ttgacatgaa gagcctgccg gactggacgg tgcaaaatgg gaagaacctg

301 accctgcagt gcttcgcgga tgtcagcacc acctctcacg tcaagcctca gcaccagatg

361 ctgttctata aggatgacgt gctgttttac aacatctcct ccatgaagag cacagagagt

421 tattttattc ctgaagtccg gatctatgac tcagggacat ataaatgtac tgtgattgtg

481 aacaacaaag agaaaaccac tgcagagtac cagctgttgg tggaaggagt gcccagtccc

541 agggtgacac tggacaagaa agaggccatc caaggtggga tcgtgagggt caactgttct

601 gtcccagagg aaaaggcccc aatacacttc acaattgaaa aacttgaact aaatgaaaaa

661 atggtcaagc tgaaaagaga gaagaattct cgagaccaga attttgtgat actggaattc

721 cccgttgagg aacaggaccg cgttttatcc ttccgatgtc aagctaggat catttctggg

781 atccatatgc agacctcaga atctaccaag agtgaactgg tcaccgtgac ggaatccttc

841 tctacaccca agttccacat cagccccacc ggaatgatca tggaaggagc tcagctccac gθl attaagtgca ccattcaagt gactcacctg gcccaggagt ttccagaaat cataattcag 61 aaggacaagg cgattgtggc ccacaacaga catggcaaca aggctgtgta ctcagtcatg

1021 gccatggtgg agcacagtgg caactacacg tgcaaagtgg agtccagccg catatccaag

1081 gtcagcagca tcgtggtcaa cataacagaa ctattttcca agcccgaact ggaatcttcc

1141 ttcacacatc tggaccaagg tgaaagactg aacctgtcct gctccatccc aggagcacct

1201 ccagccaact tcaccatcca gaaggaagat acgattgtgt cacagactca agatttcacc

1261 aagatagcct caaagtcgga cagtgggacg tatatctgca ctgcaggtat tgacaaagtg

1321 gtcaagaaaa gcaacacagt ccagatagtc gtatgtgaaa tgctctccca gcccaggatt

1381 tcttatgatg cccagtttga ggtcataaaa ggacagacca tcgaagtccg ttgcgaatcg

1441 atcagtggaa ctttgcctat ttcttaccaa cttttaaaaa caagtaaagt tttggagaat

1501 agtaccaaga actcaaatga tcctgcggta ttcaaagaca accccactga agacgtcgaa

1561 taccagtgtg ttgcagataa ttgccattcc catgccaaaa tgttaagtga ggttctgagg

1621 gtgaaggtga tagccccggt ggatgaggtc cagatttcta tcctgtcaag taaggtggtg

1681 gagtctggag aggacattgt gctgcaatgt gctgtgaatg aaggatctgg tcccatcacc

1741 tataagtttt acagagaaaa agagggcaaa cccttctatc aaatgacctc aaatgccacc

1801 caggcatttt ggaccaagca gaaggctagc aaggaacagg agggagagta ttactgcaca

1861 gccttcaaca gagccaacca cgcctccagt gtccccagaa gcaaaatact gacagtcaga

1921 gtcattcttg ccccatggaa gaaaggactt attgcagtgg ttatcatcgg agtgatcatt

1981 gctctcttga tcattgcggc caaatgttat tttctgagga aagccaaggc caagcagatg

2041 ccagtggaaa tgtccaggcc agcagtacca cttctgaact ccaacaacga gaaaatgtca

2101 gatcccaata tggaagctaa cagtcattac ggtcacaatg acgatgtcag aaaccatgca

2161 atgaaaccaa taaatgataa taaagagcct ctgaactcag acgtgcagta cacggaagtt

2221 caagtgtcct cagctgagtc tcacaaagat ctaggaaaga aggacacaga gacagtgtac

2281 agtgaagtcc ggaaagctgt ccctgatgcc gtggaaagca gatactctag aacggaaggc

2341 tcccttgatg gaacttagac agcaaggcca gatgcacatc cctggaagga catccatgtt

2401 ccgagaagaa cagataatcc ctgtatttca agacctctgt gcacttattt atgaacctgc

2461 cctgctccca cagaacacag caattcctca ggctaagctg ccggttctta aatccatcct

2521 gctaagttaa tgttgggtag aaagagatac agagggg

(2) INFORMATION FOR SEQ ID NO:2789: EPI-109 1056

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2789

1 tggtcatctc agtttctttt ctcaccttga ctgcaagatg aaactccttg tgctagctgt

61 gctgctcaca gtggccgccg ccgacagcgg catcagccct cgggccgtgt ggcagttccg

121 caaaatgatc aagtgcgtga tcccggggag tgaccccttc ttggaataca acaactacgg

181 ctgctactgt ggcttggggg gctcaggcac ccccgtggat gaactggaca agtgctgcca

241 gacacatgac aactgctatg accaggccaa gaagctggac agctgtaaat ttctgctgga

301 caacccgtac acccacacct attcatactc gtgctctggc tcggcaatca cctgtagcag

361 caaaaacaaa gagtgtgagg ccttcatttg caactgcgac cgcaacgctg ccatctgctt

421 ttcaaaagct ccatataaca aggcacacaa gaacctggac accaagaagt attgtcagag

481 ttgaatatca cctctcaaaa gcatcacctc tatctgcctc atctcacact gtactctcca 541 ataaagcacc ttgttgaaag aa

(2) INFORMATION FOR SEQ ID NO:2790: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2790

1 ctgcagaggc tcaatcactg ttcattgcag ccttgacctc cctggctcac gagatcctcc

61 catctcagcc tcctgagttg ctgggatcac aggtgcaatc caccaccaca cctggttaac

121 attttttttt ttagagatga ggtctctcta tgttgcccag gctgcacttc cttcttgtct

181 cccttatccc agcgtccgac tgaactgacg gctttgcttt ccccaaccag cccgtgaagc

241 tgggctgagt acaaagtggt gggtatgagg gtcaagattg taagatctga aaactccaga

301 aaccatccct ttggttaaca gttgctaagg acaaatgcat aacatatttt ccagtgatcc

361 catgctggca aatcgtgagg gtcattcctg caacagacag attcaaggcc agccccaaac

421 tcagccaaga gcaaagcaaa cactccagcc ttatctgggc agggttgtgt ggagactgac

481 tataagacta tacctgagac tggtcatctc agttcttttc tcaccttgac tgcaagatga

541 aactccttgt gctagctgtg ctgctcacag gtaggcaagt ctccccggct ccacccgcct

601 ttctctccca agtgagctaa gatctcactc ctctggaatg ggggccacac acagcaaaca

661 gggatggcca gccccgcagt ctcaattcga ggttcccagt gggcttaagg gctcctctat

721 tggggttccc tcaaggctgg cactttttca acctgcaagt ctgaactcag attgcctgag

781 ctaagaaagc ttgcctttat tttctttttt ccagacaggg tcttgctcta taacccaggc

841 tggagttcag tggcatgatc atagctcacc acagcttcca actcgtgggc tcaagtgatc

901 ctcccacctt actcaactaa gtagttaggc caatctccca tttattttat tttattttaa

961 tttttatttt tattttactt tattttattt ttgagacggg gctcactctg tcgccaggct

1021 ggagtgcggt gggctgatct cagatcacta caacctccat ctcctggttc aaataattct

1081 cttgcctcag cctctcaagt agctggactt gtagctctca agtagctggc acacaccacc

1141 atgcccagct aattttttgt gtgttttttt tggtagagac aggttttcac catgttggcc

1201 aggctgggtg acctcccttt tagattctcc tcatcctgct ctattcttcc cctttctaaa

1261 tgcagtatcc agtttcctta cttatacact ttattattat tcttattatt attgagacag

1321 agtcttgctt tgtgcccaag gctggagtac agtggtgcga tctcggctca ctgcaagctc

1381 cacctgctgg gttcacgcca ttctcccgcc tcagcctccc cagtagctgg gactaaagcg

1441 cctgccacca cgccccgcta atttttttgt atttttaata aagacggggt ttcatcgtgt

1501 tagccaggat ggtctcgatc tcatgacctt gtgatccgcc tgcctcggcc tcccaaatgc

1561 tggattacag gcatgagcca ccgtgcccgg ccttatcaca tttattattt attgtttttc

1621 tctcccacta ggttgtaagc tccatgaggt tagagattat tattattatt attattatta

1681 ttattattat tattattatt attatatctg ttcactgctg tatctctagc tcctaggaca

1741 gagcctggca catagtaagt gctcaataaa tattcactgg ataaacagtg cagatagttt

1801 aaaactatct gacctaggga ggctgaggca ggagaatggc gtgaacccgg gaagcagagt

1861 ttgcagtgag ctgaaatcgt gtcactgcac tccaacctgg gcaacagagc aagactccat

1921 ctcaaaaaaa aaaaaaaaac tatcaggcct agctgggtgg cacatgcctg taatcctagc

1981 tgaggcggta gggtcccaga agaagaagaa gaagaaaaag aagaagatat atatatatat

2041 acacacacac aaagatataa actttatata tataaagttt tcattaaaaa aaaaaaaaac

2101 ctctacccac tttcacttta ccaggttcct gggtccaacg gtcttcagag gaggcagctg

2161 gcaggggtca gggaggcagc gtgggacccg agggagcagg aaggcagtgt gtccccgggg

2221 tgctggcaga ccgatttgaa ctctggctat gtcttcttgc agtggccgcc gccgacagcg

2281 gcatcagccc tcgggccgtg tggcagttcc gcaaaatgat caagtgcgtg atcccgggga

2341 gtgacccctt cttggaatac aacaactacg gctgctactg tggcttgggg ggctcaggca

2401 cccccgtgga tgaactggac aagtaagtga tccgcctgca ggaaaattgg agtgcctgcc

2461 gggggcgggg tggggcacca cgccaaggat ctcacgaggc atacaaaggg gacttgcata

2521 tctgctaagg ataacatatt ttcacctctt gtcaaataaa catatatgtt ccaagaggac

2581 cctgtagcga acgcaccccg ttagagatgg aaacattgac cgacgtgcaa aacagtgggc

2641 gatgctgccc tccagtggca gaatgtagca acattaaaca tcacagcacc tatccacgtg EPI-109 1057

2701 tcattttcta gcagtggttg tcactgcccc ttctggaata caggatttta ctgtattctt 2761 gcaaccatgt taaaaatcgc tttcaggcca ggcgcggtgg ctcatgcctg taatcccagc 2821 actttgggag gccgaggcgg gcggatcact tgaggtcagg agttcgagac cagcctggcc 2881 aacatggtga aaccctgtct ctactaaaaa atacaaaaat tagccggaca tggtggcgag 2941 cgcctgtaac cccagctact tgggagactg agttggaggt ttcatgagcc aaggtcgtgt 3001 cactgctgtc cagcctgggt aacagagcaa ctctgtctca aaaaaaaaaa atgctttcaa 3061 taaatatatg ataaaaggac ttatattttt tcaagccata ggatcatttc tcctgaagca 3121 tcttggcgaa gtcatcccca cctgttcctg agagtgggca ggtgagggct gacctattgc 3181 tctgcactta ctcctatctc agctgtccct cccactttcc aggtgctgcc agacacatga 3241 caactgctac gaccaggcca agaagctgga cagctgtaaa tttctgctgg acaacccgta 3301 cacccacacc tattcatact cgtgctctgg ctcggcaatc acctgtagca gtaggtttat 3361 cccttccttg accta

(2) INFORMATION FOR SEQ ID NO:2791:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2791

1 gcccactccc accgccagct ggaaccctgg ggactacgac gtccctcaaa ccttgcttct

61 aggagataaa aagaacatcc agtcatggat aaaaatgagc tggttcagaa ggccaaactg

121 gccgagcagg ctgagcgata tgatgacatg gcagcctgca tgaagtctgt aactgagcaa

181 ggagctgaat tatccaatga ggagaggaat cttctctcag ttgcttataa aaatgttgta

241 ggagcccgta ggtcatctt^'g gagggtcgtc tcaagtattg aacaaaagac ggaaggtgct

301 gagaaaaaac agcagatggc tcgagaatac agagagaaaa ttgagacgga gctaagagat

361 atctgcaatg atgtactgtc tcttttggaa aagttcttga tccccaatgc ttcacaagca

421 gagagcaaag tcttctattt gaaaatgaaa ggagattact accgttactt ggctgaggtt

481 gccgctggtg atgacaagaa agggattgtc gatcagtcac aacaagcata ccaagaagct

541 tttgaaatca gcaaaaagga aatgcaacca acacatccta tcagactggg tctggccctt

601 aacttctctg tgttctatta tgagattctg aactccccag agaaagcctg ctctcttgca

661 aagacagctt ttgatgaagc cattgctgaa cttgatacat taagtgaaga gtcatacaaa

721 gacagcacgc taataatgca attactgaga gacaacttga cattgtggac atcggatacc

781 caaggagacg aagctgaagc aggagaagga ggggaaaatt aaccggcctt ccaacttttg

841 tctgcctcat tctaaaattt acacagtaga ccatttgtca tccatgctgt cccacaaata

901 gttttttgtt tacgatttat gacaggttta tgttacttct atttgaattt ctatatttcc

961 catgtggttt ttatgtttaa tattagggga gtagagccag ttaacattta gggagttatc

1021 tgttttcatc ttgaggtggc caatatgggg atgtggaatt tttatacaag ttataagtgt

1081 ttggcatagt acttttggta cattgtggct tcaaaagggc cagtgtaaaa ctgcttccat

1141 gtctaagcaa agaaaactgc ctacatactg gtttgtcctg gcggggaata aaagggatca

1201 ttggttccag tcacaggtgt agtaattgtg ggtactttaa ggtttggagc acttacaagg

1261 ctgtggtaga atcatacccc atggatacca catattaaac catgtatatc tgtggaatac

1321 tcaatgtgta cacctttgac tacagctgca gaagtgttcc tttagacaaa gttgtgaccc

1381 attttactct ggataagggc agaaacggtt cacattccat tatttgtaaa gttacctgct

1441 gttagctttc attatttttg ctacactcat tttatttgta tttaaatgtt ttaggcaacc

1501 taagaacaaa tgtaaaagta aagatgcagg aaaaatgaat tgcttggtat tcattacttc

1561 atgtatatca agcacagcag taaaacaaaa acccatgtat ttaacttttt tttaggattt

1621 ttgcttttgt gatttttttt tttttttttt gatacttgcc taacatgcat gtgctgtaaa

1681 aatagttaac agggaaataa cttgagatga tggctagctt tgtttaatgt cttatgaaat

1741 tttcatgaac aatccaagca taattgttaa gaacacgtgt attaaattca tgtaagtgga

1801 ataaaagttt tatgaatgga cttttcaact actttctcta cagcttttca tgtaaattag

1861 tcttggttct gaaacttctc taaaggaaat tgtacattct ttgaaattta ttccttattc

1921 cctcttggca gctaatgggc tcttaccaag tttaaacaca aaatttatca taacaaaaat

1981 actactaata taactactgt ttccatgtcc catgatcccc tctcttcctc cccaccctga

2041 aaaaaatgag ttcctatttt ttctgggaga gggggggatt gattagaaaa aaatgtagtg

2101 tgttccattt aaaattttgg catatggcat tttctaactt aggaagccac aatgttcttg

2161 gcccatcatg acattgggta gcattaactg taagttttgt gcttccaaat cactttttgg

2221 tttttaagaa tttcttgata ctcttatagc ctgccttcaa ttttgatcct ttattctttc

2281 tatttgtcag gtgcacaaga ttaccttcct gttttagcct tctgtcttgt caccaaccat

2341 tcttacttgg tggccatgta cttggaaaaa ggccgcatga tctttctggc tccactcagt

2401 gtctaaggca ccctgcttcc tttgcttgca tcccacagac tatttccctc atcctattta

2461 ctgcagcaaa tctctcctta gttgatgaga ctgtgtttat ctccctttaa aaccctacct

2521 atcctgaatg gtctgtcatt gtctgccttt aaaatccttc ctctttcttc ctcctctatt

2581 ctctaaataa tgatggggct aagttatacc caaagctcac tttacaaaat atttcctcag

2641 tactttgcag aaaacaccaa acaaaaatgc cattttaaaa aaggtgtatt ttttctttta

2701 gaatgtaagc tcctcaagag cagggacaat gttttctgta tgttctattg tgcctagtac

2761 actgtaaatg ctcaataaat attgatgatg ggaggcagtg agtcttgatg ataagggtga

2821 gaaactgaaa tccc EPI-109 1058

(2) INFORMATION FOR SEQ ID NO: 2792: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear ^•

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2792

1 tggtcatctc agtttctttt ctcaccttga ctgcaagatg aaactccttg tgctagctgt

61 gctgctcaca gtggccgccg ccgacagcgg catcagccct cgggccgtgt ggcagttccg

121 caaaatgatc aagtgcgtga tcccggggag tgaccccttc ttggaataca acaactacgg

181 ctgctactgt ggcttggggg gctcaggcac ccccgtggat gaactggaca agtgctgcca

241 gacacatgac aactgctatg accaggccaa gaagctggac agctgtaaat ttctgctgga

301 caacccgtac acccacacct attcatactc gtgctctggc tcggcaatca cctgtagcag

361 caaaaacaaa gagtgtgagg ccttcatttg caactgcgac cgcaacgctg ccatctgctt

421 ttcaaaagct ccatataaca aggcacacaa gaacctggac accaagaagt attgtcagag

481 ttgaatatca cctctcaaaa gcatcacctc tatctgcctc atctcacact gtactctcca

541 ataaagcacc ttgttgaaag aa

1 ctgcagaggc tcaatcactg ttcattgcag ccttgacctc cctggctcac gagatcctcc

61 catctcagcc tcctgagttg ctgggatcac aggtgcaatc caccaccaca cctggttaac

121 attttttttt ttagagatga ggtctctcta tgttgcccag gctgcacttc cttcttgtct

181 cccttatccc agcgtccgac tgaactgacg gctttgcttt ccccaaccag cccgtgaagc

241 tgggctgagt acaaagtggt gggtatgagg gtcaagattg taagatctga aaactccaga

301 aaccatccct ttggttaaca gttgctaagg acaaatgcat aacatatttt ccagtgatcc

361 catgctggca aatcgtgagg gtcattcctg caacagacag attcaaggcc agccccaaac

421 tcagccaaga gcaaagcaaa cactccagcc ttatctgggc agggttgtgt ggagactgac

481 tataagacta tacctgagac tggtcatctc agttcttttc tcaccttgac tgcaagatga

541 aactccttgt gctagctgtg ctgctcacag gtaggcaagt ctccccggct ccacccgcct

601 ttctctccca agtgagctaa gatctcactc ctctggaatg ggggccacac acagcaaaca

661 gggatggcca gccccgcagt ctcaattcga ggttcccagt gggcttaagg gctcctctat

721 tggggttccc tcaaggctgg cactttttca acctgcaagt ctgaactcag attgcctgag

781 ctaagaaagc ttgcctttat tttctttttt ccagacaggg tcttgctcta taacccaggc

841 tggagttcag tggcatgatc atagctcacc acagcttcca actcgtgggc tcaagtgatc

901 ctcccacctt actcaactaa gtagttaggc caatctccca tttattttat tttattttaa

961 tttttatttt tattttactt tattttattt ttgagacggg gctcactctg tcgccaggct

1021 ggagtgcggt gggctgatct cagatcacta caacctccat ctcctggttc aaataattct

1081 cttgcctcag cctctcaagt agctggactt gtagctctca agtagctggc acacaccacc

1141 atgcccagct aattttttgt gtgttttttt tggtagagac aggttttcac catgttggcc

1201 aggctgggtg acctcccttt tagattctcc tcatcctgct ctattcttcc cctttctaaa

1261 tgcagtatcc agtttcctta cttatacact ttattattat tcttattatt attgagacag

1321 agtcttgctt tgtgcccaag gctggagtac agtggtgcga tctcggctca ctgcaagctc

1381 cacctgctgg gttcacgcca ttctcccgcc tcagcctccc cagtagctgg gactaaagcg

1441 cctgccacca cgccccgcta atttttttgt atttttaata aagacggggt ttcatcgtgt

1501 tagccaggat ggtctcgatc tcatgacctt gtgatccgcc tgcctcggcc tcccaaatgc

1561 tggattacag gcatgagcca ccgtgcccgg ccttatcaca tttattattt attgtttttc

1621 tctcccacta ggttgtaagc tccatgaggt tagagattat tattattatt attattatta

1681 ttattattat tattattatt attatatctg ttcactgctg tatctctagc tcctaggaca

1741 gagcctggca catagtaagt gctcaataaa tattcactgg ataaacagtg cagatagttt

1801 aaaactatct gacctaggga ggctgaggca ggagaatggc gtgaacccgg gaagcagagt

1861 ttgcagtgag ctgaaatcgt gtcactgcac tccaacctgg gcaacagagc aagactccat

1921 ctcaaaaaaa aaaaaaaaac tatcaggcct agctgggtgg cacatgcctg taatcctagc

1981 tgaggcggta gggtcccaga agaagaagaa gaagaaaaag aagaagatat atatatatat

2041 acacacacac aaagatataa actttatata tataaagttt tcattaaaaa aaaaaaaaac

2101 ctctacccac tttcacttta ccaggttcct gggtccaacg gtcttcagag gaggcagctg

2161 gcaggggtca gggaggcagc gtgggacccg agggagcagg aaggcagtgt gtccccgggg

2221 tgctggcaga ccgatttgaa ctctggctat gtcttcttgc agtggccgcc gccgacagcg

2281 gcatcagccc tcgggccgtg tggcagttcc gcaaaatgat caagtgcgtg atcccgggga

2341 gtgacccctt cttggaatac aacaactacg gctgctactg tggcttgggg ggctcaggca

2401 cccccgtgga tgaactggac aagtaagtga tccgcctgca ggaaaattgg agtgcctgcc

2461 gggggcgggg tggggcacca cgccaaggat ctcacgaggc atacaaaggg gacttgcata

2521 tctgctaagg ataacatatt ttcacctctt gtcaaataaa catatatgtt ccaagaggac

2581 cctgtagcga acgcaccccg ttagagatgg aaacattgac cgacgtgcaa aacagtgggc

2641 gatgctgccc tccagtggca gaatgtagca acattaaaca tcacagcacc tatccacgtg

2701 tcattttcta gcagtggttg tcactgcccc ttctggaata caggatttta ctgtattctt

2761 gcaaccatgt taaaaatcgc tttcaggcca ggcgcggtgg ctcatgcctg taatcccagc

2821 actttgggag gccgaggcgg gcggatcact tgaggtcagg agttcgagac cagcctggcc

2881 aacatggtga aaccctgtct ctactaaaaa atacaaaaat tagccggaca tggtggcgag

2941 cgcctgtaac cccagctact tgggagactg agttggaggt ttcatgagcc aaggtcgtgt

3001 cactgctgtc cagcctgggt aacagagcaa ctctgtctca aaaaaaaaaa atgctttcaa

3061 taaatatatg ataaaaggac ttatattttt tcaagccata ggatcatttc tcctgaagca EPI-109 1059

3121 tcttggcgaa gtcatcccca cctgttcctg agagtgggca ggtgagggct gacctattgc

3181 tctgcactta ctcctatctc agctgtccct cccactttcc aggtgctgcc agacacatga

3241 caactgctac gaccaggcca agaagctgga cagctgtaaa tttctgctgg acaacccgta

3301 cacccacacc tattcatact cgtgctctgg ctcggcaatc acctgtagca gtaggtttat

3361 cccttccttg accta

1 gcccactccc accgccagct ggaaccctgg ggactacgac gtccctcaaa ccttgcttct

61 aggagataaa aagaacatcc agtcatggat aaaaatgagc tggttcagaa ggccaaactg

121 gccgagcagg ctgagcgata tgatgacatg gcagcctgca tgaagtctgt aactgagcaa

181 ggagctgaat tatccaatga ggagaggaat cttctctcag ttgcttataa aaatgttgta

241 ggagcccgta ggtcatcttg gagggtcgtc tcaagtattg aacaaaagac ggaaggtgct

301 gagaaaaaac agcagatggc tcgagaatac agagagaaaa ttgagacgga gctaagagat

361 atctgcaatg atgtactgtc tcttttggaa aagttcttga tccccaatgc ttcacaagca

421 gagagcaaag tcttctattt gaaaatgaaa ggagattact accgttactt ggctgaggtt

481 gccgctggtg atgacaagaa agggattgtc gatcagtcac aacaagcata ccaagaagct

541 tttgaaatca gcaaaaagga aatgcaacca acacatccta tcagactggg tctggccctt

601 aacttctctg tgttctatta tgagattctg aactccccag agaaagcctg ctctcttgca

661 aagacagctt ttgatgaagc cattgctgaa cttgatacat taagtgaaga gtcatacaaa

721 gacagcacgc taataatgca attactgaga gacaacttga cattgtggac atcggatacc

781 caaggagacg aagctgaagc aggagaagga ggggaaaatt aaccggcctt ccaacttttg

841 tctgcctcat tctaaaattt acacagtaga ccatttgtca tccatgctgt cccacaaata

901 gttttttgtt tacgatttat gacaggttta tgttacttct atttgaattt ctatatttcc

961 catgtggttt ttatgtttaa tattagggga gtagagccag ttaacattta gggagttatc

1021 tgttttcatc ttgaggtggc caatatgggg atgtggaatt tttatacaag ttataagtgt

1081 ttggcatagt acttttggta cattgtggct tcaaaagggc cagtgtaaaa ctgcttccat

1141 gtctaagcaa agaaaactgc ctacatactg gtttgtcctg gcggggaata aaagggatca

1201 ttggttccag tcacaggtgt agtaattgtg ggtactttaa ggtttggagc acttacaagg

1261 ctgtggtaga atcatacccc atggatacca catattaaac catgtatatc tgtggaatac

1321 tcaatgtgta cacctttgac tacagctgca gaagtgttcc tttagacaaa gttgtgaccc

1381 attttactct ggataagggc agaaacggtt cacattccat tatttgtaaa gttacctgct

1441 gttagctttc attatttttg ctacactcat tttatttgta tttaaatgtt ttaggcaacc

1501 taagaacaaa tgtaaaagta aagatgcagg aaaaatgaat tgcttggtat tcattacttc

1561 atgtatatca agcacagcag taaaacaaaa acccatgtat ttaacttttt tttaggattt

1621 ttgcttttgt gatttttttt tttttttttt gatacttgcc taacatgcat gtgctgtaaa

1681 aatagttaac agggaaataa cttgagatga tggctagctt tgtttaatgt cttatgaaat

1741 tttcatgaac aatccaagca taattgttaa gaacacgtgt attaaattca tgtaagtgga

1801 ataaaagttt tatgaatgga cttttcaact actttctcta cagcttttca tgtaaattag

1861 tcttggttct gaaacttctc taaaggaaat tgtacattct ttgaaattta ttccttattc

1921 cctcttggca gctaatgggc tcttaccaag tttaaacaca aaatttatca taacaaaaat

1981 actactaata taactactgt ttccatgtcc catgatcccc tctcttcctc cccaccctga

2041 aaaaaatgag ttcctatttt ttctgggaga gggggggatt gattagaaaa aaatgtagtg

2101 tgttccattt aaaattttgg catatggcat tttctaactt aggaagccac aatgttcttg

2161 gcccatcatg acattgggta gcattaactg taagttttgt gcttccaaat cactttttgg

2221 tttttaagaa tttcttgata ctcttatagc ctgccttcaa ttttgatcct ttattctttc

2281 tatttgtcag gtgcacaaga ttaccttcct gttttagcct tctgtcttgt caccaaccat

2341 tcttacttgg tggccatgta cttggaaaaa ggccgcatga tctttctggc tccactcagt

2401 gtctaaggca ccctgcttcc tttgcttgca tcccacagac tatttccctc atcctattta

2461 ctgcagcaaa tctctcctta gttgatgaga ctgtgtttat ctccctttaa aaccctacct

2521 atcctgaatg gtctgtcatt gtctgccttt aaaatccttc ctctttcttc ctcctctatt

2581 ctctaaataa tgatggggct aagttatacc caaagctcac tttacaaaat atttcctcag

2641 tactttgcag aaaacaccaa acaaaaatgc cattttaaaa aaggtgtatt ttttctttta

2701 gaatgtaagc tcctcaagag cagggacaat gttttctgta tgttctattg tgcctagtac

2761 actgtaaatg ctcaataaat attgatgatg ggaggcagtg agtcttgatg ataagggtga

2821 gaaactgaaa tccc

(2) INFORMATION FOR SEQ ID NO:2793: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2793 1 gctgtgcaac ctcggcgcca tgcgcaacct ctatgcgatg caccggcggc tgcagcggca 61 cccgcgctcc tgcaccaggg actgtgccga gccgcgcgcg gacgggaggg aagcgtcccc 121 tcagcccctg gaggagctgg atcacctcct gctgctggcg ctgatgaccg tgctcttcac 181 tatgtgttct ctgcccgtaa tttatcgcgc ttactatgga gcatttaagg atgtcaagga 241 gaaaaacagg acctctgaag aagcagaaga cctccgagcc ttgcgatttc tatctgtgat 301 ttcaattgtg gacccttgga tttttatcat tttcagatct ccagtatttc ggatattttt 361 tcacaagatt ttcattagac ctcttaggta caggagccgg tgcagcaatt ccactaacat 421 ggaatccagt ctgtgacagt gtttttcact ctgtggtaag ctgaggaata tgtcacattt EPI-109 1060

481 tcagtcaaag aacca

(2) INFORMATION FOR SEQ ID NO:2794: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2794

1 gaattctggc tattttcctc ctgccgttcc gactcggcac cagagtctgt ctctactgag

61 aacgcagcgc gtcagggccg agctcttcac tggcctgctc cgcgctcttc aatgccagcg

121 ccaggcgctc accctgcaga gcgtcccgcc tctcaaagag gggtgtgacc cgcgagttta

181 gataggaggt tcctgccgtg gggaacaccc cgccgccctc ggagcttttt ctgtggcgca

241 gcttctccgc ccgagccgcg cgcggagctg ccgggggctc cttagcaccc gggcgccggg

301 gccctcgccc ttccgcagcc ttcactccag ccctctgctc ccgcacgcca tgaagtcgcc

361 gttctaccgc tgccagaaca ccacctctgt ggaaaaaggc aactcggcgg tgatgggcgg

421 ggtgctcttc agcaccggcc tcctgggcaa cctgctggcc ctggggctgc tggcgcgctc

481 ggggctgggg tggtgctcgc ggcgtccact gcgcccgctg ccctcggtct tctacatgct

541 ggtgtgtggc ctgacggtca ccgacttgct gggcaagtgc ctcctaagcc cggtggtgct

601 ggctgcctac gctcagaacc ggagtctgcg ggtgcttgcg cccgcattgg acaactcgtt

661 gtgccaagcc ttcgccttct tcatgtcctt ctttgggctc tcctcgacac tgcaactcct

721 ggccatggca ctggagtgct ggctctccct agggcaccct ttcttctacc gacggcacat

781 caccctgcgc ctgggcgcac tggtggcccc ggtggtgagc gccttctccc tggctttctg

841 cgcgctacct ttcatgggct tcgggaagtt cgtgcagtac tgccccggca cctggtgctt

901 tatccagatg gtccacgagg agggctcgct gtcggtgctg gggtactctg tgctctactc

961 cagcctcatg gcgctgctgg tcctcgccac cgtgctgtgc aacctcggcg ccatgcgcaa

1021 cctctatgcg atgcaccggc ggctgcagcg gcacccgcgc tcctgcacca gggactgtgc

1081 cgagccgcgc gcggacggga gggaagcgtc ccctcagccc ctggaggagc tggatcacct

1141 cctgctgctg gcgctgatga ccgtgctctt cactatgtgt tctctgcccg taattgtgag

1201 tccccgggcc ccgagg

(2) INFORMATION FOR SEQ ID NO: 2795: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2795

1 gggccgccgt cggcgcgctg ggtgcgggaa gggggctctg gatttcggtc cctccccttt

61 ttcctctgag tctcggaacg ctccagctct cagaccctct tcctcccagg taaaggccgg

121 gagaggaggg cgcatctctt ttccaggcac cccaccatgg gcaatgcctc caatgactcc

181 cagtctgagg actgcgagac gcgacagtgg cttcccccag gcgaaagccc agccatcagc

241 tccgtcatgt tctcggccgg ggtgctgggg aacctcatag cactggcgct gctggcgcgc

301 cgctggcggg gggacgtggg gtgcagcgcc ggccgcagga gctccctctc cttgttccac

361 gtgctggtga ccgagctggt gttcaccgac ctgctcggga cctgcctcat cagcccagtg

421 gtactggctt cgtacgcgcg gaaccagacc ctggtggcac tggcgcccga gagccgcgcg

481 tgcacctact tcgctttcgc catgaccttc ttcagcctgg ccacgatgct catgctcttc

541 gccatggccc tggagcgcta cctctcgatc gggcacccct acttctacca gcgccgcgtc

601 tcggcctccg ggggcctggc cgtgctgcct gtcatctatg cagtctccct gctcttctgc

661 tcgctgccgc tgctggacta tgggcagtac gtccagtact gccccgggac ctggtgcttc

721 atccggcacg ggcggaccgc ttacctgcag ctgtacgcca ccctgctgct gcttctcatt

781 gtctcggtgc tcgcctgcaa cttcagtgtc attctcaacc tcatccgcat gcaccgccga

841 agccggagaa gccgctgcgg accttccctg ggcagtggcc ggggcggccc cggggcccgc

901 aggagagggg aaagggtgtc catggcggag gagacggacc acctcattct cctggctatc

961 atgaccatca ccttcgccgt ctgctccttg cctttcacga tttttgcata tatgaatgaa

1021 acctcttccc gaaaggaaaa atgggacctc caagctctta ggtttttatc aattaattca

1081 ataattgacc cttgggtctt tgccatcctt aggcctcctg ttctgagact aatgcgttca

1141 gtcctctgtt gtcggatttc attaagaaca caagatgcaa cacaaacttc ctgttctaca

1201 cagtcagatg ccagtaaaca ggctgacctt tgaggtcagt agtttaaaag ttcttagtta

1261 tatagcatct ggaagatcat tttgaaattg ttccctggag aaatgaaaac agtgtgtaaa

1321 caaaatgaag ctgccctaat aaaaaggagt atacaaacat ttaagctgtg gtcaaggcta

1381 cagatgtgct gacaaggcac ttcatgtaaa gtgtcagaag gagctacaaa acctaccctc

1441 aatgagcatg gtacttggcc tttggaggaa caatcggctg cattgaagat ccagctgcct

1501 attgatttaa gctttcctgt tgaatgacaa agtatgtggt tttgtaattt gtttgaaacc

1561 ccaaacagtg actgtacttt ctattttaat cttgctacta ccgttataca catatagtgt

1621 acagccagac cagattaaac ttcatatgta atctctagga agtcaatatg tggaagcaac

1681 caagcctgct gtcttgtgat cacttagcga accctttatt tgaacaatga agttgaaaat

1741 cataggcacc ttttactgtg atgtttgtgt atgtgggagt actctcatca ctacagtatt

1801 actcttacaa gagtggactc agtgggttaa catcagtttt gtttactcat cctccaggaa EPI-109 1061

1861 ctgcaggtca agttgtcagg ttatttattt tataatgtcc atatgctaat agtgatcaag 1921 aagactttag gaatggttct ctcaacaaga aataatagaa atgtctcaag gcagttaatt 1981 ctcattaata ctcttattat cctatttctg ggggaggatg tacgtggcca tgtatgaagc 2041 caaatattag gcttaaaaac tgaaaaatct ggttcattct tcagatatac tggaaccctt 2101 ttaaagttga tattggggcc atgagtaaaa tagattttat aagatgactg tgttgtacca 2161 aaattcatct gtctatattt tatttagggg aacatggttt gactcatctt atatgggaaa 2221 ccatgtagca gtgagtcata tcttaatata tttctaaatg tttggcatgt aaatgtaaac 2281 tcagcatcaa aatatttcag tgaatttgca ctgtttaatc atagttactg tgtaaactca 2341 tctgaaatgt tacaaaaata aactataaaa ca

(2) INFORMATION FOR SEQ ID NO:2796: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2796

1 agagaggaag gcgtggctcc ctcccgggcc agtgagccct ggcgccgccg cggccgcggt

61 cccagcagcg gagtagggcg gcggctgcgc cccgcaccat ggggggcagc ccagccccag

121 ccgcggtaaa cgccgacctc cgccgccgcc cgcgccgcgt ctgccccctc ccgctgcggc

181 tctctggacg ccatcccctc ctcacctcga agccaacatg aaggagaccc ggggctacgg

241 aggggatgcc cccttctgca cccgcctcaa ccactcctac acaggcatgt gggcgcccga

301 gcgttccgcc gaggcgcggg gcaacctcac gcgccctcca gggtctggcg aggattgcgg

361 atcggtgtcc gtggccttcc cgatcaccat gctgctcact ggtttcgtgg gcaacgcact

421 ggccatgctg ctcgtgtcgc gcagctaccg gcgccgggag agcaagcgca agaagtcctt

481 cctgctgtgc atcggctggc tggcgctcac cgacctggtc gggcagcttc tcaccacccc

541 ggtcgtcatc gtcgtgtacc tgtccaagca gcgttgggag cacatcgacc cgtcggggcg

601 gctctgcacc tttttcgggc tgaccatgac tgttttcggg ctctcctcgt tgttcatcgc

661 cagcgccatg gccgtcgagc gggcgctggc catcagggcg ccgcactggt atgcgagcca

721 catgaagacg cgtgccaccc gcgctgtgct gctcggcgtg tggctggccg tgctcgcctt

781 cgccctgctg ccggtgctgg gcgtgggcca gtacaccgtc cagtggcccg ggacgtggtg

841 cttcatcagc accgggcgag ggggcaacgg gactagctct tcgcataact ggggcaacct

901 tttcttcgcc tctgcctttg ccttcctggg gctcttggcg ctgacagtca ccttttcctg

961 caacctggcc accattaagg ccctggtgtc ccgctgccgg gccaaggcca cggcatctca

1021 gtccagtgcc cagtggggcc gcatcacgac cgagacggcc attcagctta tggggatcat

1081 gtgcgtgctg tcggtctgct ggtctccgct cctgataatg atgttgaaaa tgatcttcaa

1141 tcagacatca gttgagcact gcaagacaca cacggagaag cagaaagaat gcaacttctt

1201 cttaatagct gttcgcctgg cttcactgaa ccagatcttg gatccttggg tttacctgct

1261 gttaagaaag atccttcttc gaaagttttg ccaggtagca aatgctgtct ccagctgctc

1321 taatgatgga cagaaagggc agcctatctc attatctaat gaaataatac agacagaagc

1381 atgaaagaaa acacttaact tgcatgtgca cagcttctgg taacaaatat cgctaaacct

1441 tactgtgaat ttaggcatct ctggcatgcc actgtttatg cattgaagtg gaatttttgg

1501 tataaagcta aatggtctta gaagcataga aaatccctat gtgccaaaag tagtgaaaca

1561 caaacaaagg aaaatatatt aataacagtc tagtgttttt gttgagtctg ccattcgtag

1621 ctgaatatgt gattaattat gtgatgaaaa ctttttttat aaatgatctt ggtctattgg

1681 gg

(2) INFORMATION FOR SEQ ID NO: 2797: (i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2797

1 cccgggccag tgagccctgg cgccgccgcg gccgcggtcc cagcagcgga gtagggcggc

61 ggctgcgccc cgcaccatgg ggggcagccc agccccagcc gcggtaaacg ccgacctccg

121 ccgccgcccg cgccgcgtct gccccctccc gctgcggctc tctggacgcc atcccctcct

181 cacctcgaag ccaacatgaa ggagacccgg ggctacggag gggatgcccc cttctgcacc

241 cgcctcaacc actcctacac aggcatgtgg gcgcccgagc gttccgccga ggcgcggggc

301 aacctcacgc gccctccagg gtctggcgag gattgcggat cggtgtccgt ggccttcccg

361 atcaccatgc tgctcactgg tttcgtgggc aacgcactgg ccatgctgct cgtgtcgcgc

421 agctaccggc gccgggagag caagcgcaag aagtccttcc tgctgtgcat cggctggctg

481 gcgctcaccg acctggtcgg gcagcttctc accaccccgg tcgtcatcgt cgtgtacctg

541 tccaagcagc gttgggagca catcgacccg tcggggcggc tctgcacctt tttcgggctg

601 accatgactg ttttcgggct ctcctcgttg ttcatcgcca gcgccatggc cgtcgagcgg

661 gcgctggcca tcagggcgcc gcactggtat gcgagccaca tgaagacgcg tgccacccgc

721 gctgtgctgc tcggcgtgtg gctggccgtg ctcgccttcg ccctgctgcc ggtgctgggc

781 gtgggccagt acaccgtcca gtggcccggg acgtggtgct tcatcagcac cgggcgaggg

841 ggcaacggga ctagctcttc gcataactgg ggcaaccttt tcttcgcctc tgcctttgcc EPI-109 1062

901 ttcctggggc tcttggcgct gacagtcacc ttttcctgca acctggccac cattaaggcc 961 ctggtgtccc gctgccgggc caaggccacg gcatctcagt ccagtgccca gtggggccgc 1021 atcacgaccg agacggccat tcagcttatg gggatcatgt gcgtgctgtc ggtctgctgg 1081 tctccgctcc tgataatgat gttgaaaatg atcttcaatc agacatcagt tgagcactgc 1141 aagacacaca cggagaagca gaaagaatgc aacttcttct taatagctgt tcgcctggct 1201 tcactgaacc agatcttgga tccttgggtt tacctgctgt taagaaagat ccttcttcga 1261 aagttttgcc agatcaggta ccacacaaac aactatgcat ccagctccac ctccttaccc 1321 tgccagtgtt cctcaacctt gatgtggagc gaccatttgg aaagataatg aaagaacgga 1381 gttggacatt ttattgcaat tcctgcttcc ctgaatttgc atatttcttc ccacctgaga 1441 aggataatta tatattttaa tttggattat ttcttcattt ttatcttttt attttaatga 1501 ttgttttgtc agtaataccc atggagatca actttattat tataatccat gcctctgaat 1561 attagattgg tttcttggat gggattttga atatgcattt aagaagttgg gaagaatttc 1621 acagatgatg attggaggaa aagtgatgaa aagaaagacc tgtgttccag gagttttctc 1681 caacttcaaa cctttacgtg aatcttaacc aaagtggaca tctttacatt tcatgatagc 1741 ttgcttttgc aatatgagtt tgaaaaatca gtataagctt atgatggtga aaagtcaaca 1801 tattgagagt gataattcaa ttaataggat atgaacttaa cgatataaaa gcaaatgagg 1861 gcaggagggg

(2) INFORMATION FOR SEQ ID NO: 2798: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2798

1 agagaggaag gcgtggctcc ctcccgggcc agtgagccct ggcgccgccg cggccgcggt

61 cccagcagcg gagtagggcg gcggctgcgc cccgcaccat ggggggcagc ccagccccag

121 ccgcggtaaa cgccgacctc cgccgccgcc cgcgccgcgt ctgccccctc ccgctgcggc

181 tctctggacg ccatcccctc ctcacctcga agccaacatg aaggagaccc ggggctacgg

241 aggggatgcc cccttctgca cccgcctcaa ccactcctac acaggcatgt gggcgcccga

301 gcgttccgcc gaggcgcggg gcaacctcac gcgccctcca gggtctggcg aggattgcgg

361 atcggtgtcc gtggccttcc cgatcaccat gctgctcact ggtttcgtgg gcaacgcact

421 ggccatgctg ctcgtgtcgc gcagctaccg gcgccgggag agcaagcgca agaagtcctt

481 cctgctgtgc atcggctggc tggcgctcac cgacctggtc gggcagcttc tcaccacccc

541 ggtcgtcatc gtcgtgtacc tgtccaagca gcgttgggag cacatcgacc cgtcggggcg

601 gctctgcacc tttttcgggc tgaccatgac tgttttcggg ctctcctcgt tgttcatcgc

661 cagcgccatg gccgtcgagc gggcgctggc catcagggcg ccgcactggt atgcgagcca

721 catgaagacg cgtgccaccc gcgctgtgct gctcggcgtg tggctggccg tgctcgcctt

781 cgccctgctg ccggtgctgg gcgtgggcca gtacaccgtc cagtggcccg ggacgtggtg

841 cttcatcagc accgggcgag ggggcaacgg gactagctct tcgcataact ggggcaacct

901 tttcttcgcc tctgcctttg ccttcctggg gctcttggcg ctgacagtca ccttttcctg

961 caacctggcc accattaagg ccctggtgtc ccgctgccgg gccaaggcca cggcatctca

1021 gtccagtgcc cagtggggcc gcatcacgac cgagacggcc attcagctta tggggatcat

1081 gtgcgtgctg tcggtctgct ggtctccgct cctgataatg atgttgaaaa tgatcttcaa

1141 tcagacatca gttgagcact gcaagacaca cacggagaag cagaaagaat gcaacttctt

1201 cttaatagct gttcgcctgg cttcactgaa ccagatcttg gatccttggg tttacctgct

1261 gttaagaaag atccttcttc gaaagttttg ccaggtagca aatgctgtct ccagctgctc

1321 taatgatgga cagaaagggc agcctatctc attatctaat gaaataatac agacagaagc

1381 atgaaagaaa acacttaact tgcatgtgca cagcttctgg taacaaatat cgctaaacct

1441 tactgtgaat ttaggcatct ctggcatgcc actgtttatg cattgaagtg gaatttttgg

1501 tataaagcta aatggtctta gaagcataga aaatccctat gtgccaaaag tagtgaaaca

1561 caaacaaagg aaaatatatt aataacagtc tagtgttttt gttgagtctg ccattcgtag

1621 ctgaatatgt gattaattat gtgatgaaaa ctttttttat aaatgatctt ggtctattgg

1681 gg

(2) INFORMATION FOR SEQ ID NO: 2799: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2799

1 agagaggaag gcgtggctcc ctcccgggcc agtgagccct ggcgccgccg cggccgcggt 61 cccagcagcg gagtagggcg gcggctgcgc cccgcaccat ggggggcagc ccagccccag 121 ccgcggtaaa cgccgacctc cgccgccgcc cgcgccgcgt ctgccccctc ccgctgcggc 181 tctctggacg ccatcccctc ctcacctcga agccaacatg aaggagaccc ggggctacgg 241 aggggatgcc cccttctgca cccgcctcaa ccactcctac acaggcatgt gggcgcccga 301 gcgttccgcc gaggcgcggg gcaacctcac gcgccctcca gggtctggcg aggattgcgg 361 atcggtgtcc gtggccttcc cgatcaccat gctgctcact ggtttcgtgg gcaacgcact EPI-109 1063

421 ggccatgctg ctcgtgtcgc gcagctaccg gcgccgggag agcaagcgca agaagtcctt

481 cctgctgtgc atcggctggc tggcgctcac cgacctggtc gggcagcttc tcaccacccc

541 ggtcgtcatc gtcgtgtacc tgtccaagca gcgttgggag cacatcgacc cgtcggggcg

601 gctctgcacc tttttcgggc tgaccatgac tgttttcggg ctctcctcgt tgttcatcgc

661 cagcgccatg gccgtcgagc gggcgctggc catcagggcg ccgcactggt atgcgagcca

721 catgaagacg cgtgccaccc gcgctgtgct gctcggcgtg tggctggccg tgctcgcctt

781 cgccctgctg ccggtgctgg gcgtgggcca gtacaccgtc cagtggcccg ggacgtggtg

841 cttcatcagc accgggcgag ggggcaacgg gactagctct tcgcataact ggggcaacct

901 tttcttcgcc tctgcctttg ccttcctggg gctcttggcg ctgacagtca ccttttcctg

961 caacctggcc accattaagg ccctggtgtc ccgctgccgg gccaaggcca cggcatctca

1021 gtccagtgcc cagtggggcc gcatcacgac cgagacggcc attcagctta tggggatcat

1081 gtgcgtgctg tcggtctgct ggtctccgct cctgataatg atgttgaaaa tgatcttcaa

1141 tcagacatca gttgagcact gcaagacaca cacggagaag cagaaagaat gcaacttctt

1201 cttaatagct gttcgcctgg cttcactgaa ccagatcttg gatccttggg tttacctgct

1261 gttaagaaag atccttcttc gaaagttttg ccaggaggaa ttttggggaa attaaaacct

1321 gcctttctgc caggatcaca tcactggaag ctccatgact ctctttttgt aaaagaaaa

(2) INFORMATION FOR SEQ ID NO:2800: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2800

1 gtgcgcggag gggacgagcg gctggaccac agccggcgcc cgatcaggat ctccgcgctg

61 ggatcggtgg aacttgaggc agcggcggcg cggggcgcca tggcacaccg agcggctccg

121 tcttctgctc ctcagagagc ccggctggcg gcctgggatg acaagatgtc tggactgcaa

181 tcctgcacag ttttgagagg gagatgactt gagtggttgg cttttatctc cacaacaatg

241 tccatgaaca attccaaaca gctagtgtct cctgcagctg cgcttctttc aaacacaacc

301 tgccagacgg aaaaccggct ttccgtattt ttttcagtaa tcttcatgac agtgggaatc

361 ttgtcaaaca gccttgccat cgccattctc atgaaggcat atcagagatt tagacagaag

421 tccaaggcat cgtttctgct tttggccagc ggcctggtaa tcactgattt ctttggccat

481 ctcatcaatg gagccatagc agtatttgta tatgcttctg ataaagaatg gatccgcttt

541 gaccaatcaa atgtcctttg cagtattttt ggtatctgca tggtgttttc tggtctgtgc

601 ccacttcttc taggcagtgt gatggccatt gagcggtgta ttggagtcac aaaaccaata

661 tttcattcta cgaaaattac atccaaacat gtgaaaatga tgttaagtgg tgtgtgcttg

721 tttgctgttt tcatagcttt gctgcccatc cttggacatc gagactataa aattcaggcg

781 tcgaggacct ggtgtttcta caacacagaa gacatcaaag actgggaaga tagattttat

841 cttctacttt tttcttttct ggggctctta gcccttggtg tttcattgtt gtgcaatgca

901 atcacaggaa ttacactttt aagagttaaa tttaaaagtc agcagcacag acaaggcaga

961 tctcatcatt tggaaatggt aatccagctc ctggcgataa tgtgtgtctc ctgtatttgt

1021 tggagcccat ttctggttac aatggccaac attggaataa atggaaatca ttctctggaa

1081 acctgtgaaa caacactttt tgctctccga atggcaacat ggaatcaaat cttagatcct

1141 tgggtatata ttcttctacg aaaggctgtc cttaagaatc tctataagct tgccagtcaa

1201 tgctgtggag tgcatgtcat cagcttacat atttgggagc ttagttccat taaaaattcc

1261 ttaaaggttg ctgctatttc tgagtcacca gttgcagaga aatcagcaag cacctagctt

1321 aataggacag taaatctgtg tggggctaga acaaaaatta agacatgttt ggcaatattt

1381 cagttagtta aatacctgta gcctaactgg aaaattcagg cttcatcatg tagtttgaag

1441 atactattgt cagattcagg ttttgaaatt tgtcaaataa acaggataac tgtacatttt

1501 caacttgttt ttgccaatgg gaggtagaca caataaaata atgccatggg agtcacactg

1561 aaagcaattt tgagcttatc tgtcttattt atgctttgag tgaatcatct gttgaggtct

1621 aatgcctcta cttggcctat ttgccagaga acatcttaat gcagcctgca tagtgaaatg

1681 gttattttga gatcaccgct ctgtagctaa cccttataaa ctaggctcag taaaataaag

1741 cactcttatt ttttgatctg gcctattttg cccctcattg tgtagcctca attaacacat

1801 gcatggtcat gacacccaga attcatgatg gtttgttata acaacctctg catattccag

1861 gtctggcaga caggttgcct gaccctgcaa tcctatctag aatgggccca ttcttgtcac

1921 atttgacaaa taggactgcc tacatttatt attatgaagg tcgattgttg ttggaagtgt

1981 tttttcatgt catagattag caattttcaa ataattattt tttctctgaa aattttgtgt

2041 gtgattgcac aataaataat ttttagagaa acaaaggctc tttctcagca cattgatggg

2101 caactagaat tacagcagtt tcaaactcta ccatggataa tgcaaacaaa ccgaagctac

2161 atgccaatga taggtgcaaa gaatattggc aaaaggtgct ttaccttgag ccattatttg

2221 tgtcagagaa caaaagaaac agaatcaata tataaattca aagactatct gcagctagtg

2281 tgtttcttct ttacacacat atacacacag acatcagaaa attctgttga gagcaggttc

2341 attaaatttg taagatggca tattctaaag cctgtgctac cagtactaag aggggaagac

2401 tggcaatttg ccaagcactt ggggattatt ataacaatta actaggagat caagagataa

2461 taatctctcc ccaaattttc caataataat tgag

(2) INFORMATION FOR SEQ ID NO:2801: (i) SEQUENCE CHARACTERISTICS: EPI-109 1064

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2801

1 ggcacagacg cacgggacag gagagcctgg gcaagactgg agagcccaga cctgggatgg

61 cggattcgtg caggaacctc acctacgtgc ggggctcggt ggggccggcc accagcaccc

121 tgatgttcgt ggccggtgtg gtgggcaacg ggctggccct gggcatcctg agcgcacggc

181 gaccggcgcg cccctcggcc ttcgcggtgc tggtcaccgg actggcggcc accgacctgc

241 tgggcaccag cttcctgagc ccggccgtgt tcgtggccta tgcgcgcaac agctccctgc

301 tgggcctggc ccgaggcggc cccgccctgt gcgatgcctt cgccttcgcc atgaccttct

361 tcggcctggc gtccatgctc atcctctttg ccatggccgt ggagcgctgc ctggcgctga

421 gccaccccta cctctacgcg cagctggacg ggccccgctg cgcccgcctg gcgctgccag

481 ccatctacgc cttctgcgtc ctcttctgcg cgctgcccct gctgggcctg ggccaacacc

541 agcagtactg ccccggcagc tggtgcttcc tccgcatgcg ctgggcccag ccgggcggcg

601 ccgccttctc gctggcctac gccggcctgg tggccctgct ggtggctgcc atcttcctct

661 gcaacggctc ggtcaccctc agcctctgcc gcatgtaccg ccagcagaag cgccaccagg

721 gctctctggg tccacggccg cgcaccggag aggacgaggt ggaccacctg atcctgctgg

781 ccctcatgac agtggtcatg gccgtgtgct ccctgcctct cacgatccgc tgcttcaccc

841 aggctgtcgc ccctgacagc agcagtgaga tgggggacct ccttgccttc cgcttctacg gθl ccttcaaccc catcctggac ccctgggtct tcatcctttt ccgcaaggct gtcttccagc

961 gactcaagct ctgggtctgc tgcctgtgcc tcgggcctgc ccacggagac tcgcagacac

1021 ccctttccca gctcgcctcc gggaggaggg acccaagggc cccctctgct cctgtgggaa

1081 aggaggggag ctgcgtgcct ttgtcggctt ggggcgaggg gcaggtggag cccttgcctc

1141 ccacacagca gtccagcggc agcgccgtgg gaacgtcgtc caaagcagaa gccagcgtcg

1201 cctgctccct ctgctgacat ttcaagctga ccctgtgatc tctgccctgt cttcgggcga

1261 caggagccag aaaatcaggg acatggctga tggctgcgga tgctggaacc ttggccccca

1321 aactctgggg ccgatcagct gctgtttctc tgcggcaggg cagtcgctgc tggctctggg

1381 aagagagtga gggacagagg aaacgtttat cctggag

(2) INFORMATION FOR SEQ ID NO: 2802: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2802

1 gctgtgcaac ctcggcgcca tgcgcaacct ctatgcgatg caccggcggc tgcagcggca

61 cccgcgctcc tgcaccaggg actgtgccga gccgcgcgcg gacgggaggg aagcgtcccc

121 tcagcccctg gaggagctgg atcacctcct gctgctggcg ctgatgaccg tgctcttcac

181 tatgtgttct ctgcccgtaa tttatcgcgc ttactatgga gcatttaagg atgtcaagga

241 gaaaaacagg acctctgaag aagcagaaga cctccgagcc ttgcgatttc tatctgtgat

301 ttcaattgtg gacccttgga tttttatcat tttcagatct ccagtatttc ggatattttt

361 tcacaagatt ttcattagac ctcttaggta caggagccgg tgcagcaatt ccactaacat

421 ggaatccagt ctgtgacagt gtttttcact ctgtggtaag ctgaggaata tgtcacattt

481 tcagtcaaag aacca

1 gaattctggc tattttcctc ctgccgttcc gactcggcac cagagtctgt ctctactgag

61 aacgcagcgc gtcagggccg agctcttcac tggcctgctc cgcgctcttc aatgccagcg

121 ccaggcgctc accctgcaga gcgtcccgcc tctcaaagag gggtgtgacc cgcgagttta

181 gataggaggt tcctgccgtg gggaacaccc cgccgccctc ggagcttttt ctgtggcgca

241 gcttctccgc ccgagccgcg cgcggagctg ccgggggctc cttagcaccc gggcgccggg

301 gccctcgccc ttccgcagcc ttcactccag ccctctgctc ccgcacgcca tgaagtcgcc

361 gttctaccgc tgccagaaca ccacctctgt ggaaaaaggc aactcggcgg tgatgggcgg

421 ggtgctcttc agcaccggcc tcctgggcaa cctgctggcc ctggggctgc tggcgcgctc

481 ggggctgggg tggtgctcgc ggcgtccact gcgcccgctg ccctcggtct tctacatgct

541 ggtgtgtggc ctgacggtca ccgacttgct gggcaagtgc ctcctaagcc cggtggtgct

601 ggctgcctac gctcagaacc ggagtctgcg ggtgcttgcg cccgcattgg acaactcgtt

661 gtgccaagcc ttcgccttct tcatgtcctt ctttgggctc tcctcgacac tgcaactcct

721 ggccatggca ctggagtgct ggctctccct agggcaccct ttcttctacc gacggcacat

781 caccctgcgc ctgggcgcac tggtggcccc ggtggtgagc gccttctccc tggctttctg

841 cgcgctacct ttcatgggct tcgggaagtt cgtgcagtac tgccccggca cctggtgctt

901 tatccagatg gtccacgagg agggctcgct gtcggtgctg gggtactctg tgctctactc

961 cagcctcatg gcgctgctgg tcctcgccac cgtgctgtgc aacctcggcg ccatgcgcaa

1021 cctctatgcg atgcaccggc ggctgcagcg gcacccgcgc tcctgcacca gggactgtgc

1081 cgagccgcgc gcggacggga gggaagcgtc ccctcagccc ctggaggagc tggatcacct

1141 cctgctgctg gcgctgatga ccgtgctctt cactatgtgt tctctgcccg taattgtgag

1201 tccccgggcc ccgagg

1 gggccgccgt cggcgcgctg ggtgcgggaa gggggctctg gatttcggtc cctccccttt

61 ttcctctgag tctcggaacg ctccagctct cagaccctct tcctcccagg taaaggccgg EPI-109 1065

121 gagaggaggg cgcatctctt ttccaggcac cccaccatgg gcaatgcctc caatgactcc

181 cagtctgagg actgcgagac gcgacagtgg cttcccccag gcgaaagccc agccatcagc

241 tccgtcatgt tctcggccgg ggtgctgggg aacctcatag cactggcgct gctggcgcgc

301 cgctggcggg gggacgtggg gtgcagcgcc ggccgcagga gctccctctc cttgttccac

361 gtgctggtga ccgagctggt gttcaccgac ctgctcggga cctgcctcat cagcccagtg

421 gtactggctt cgtacgcgcg gaaccagacc ctggtggcac tggcgcccga gagccgcgcg

481 tgcacctact tcgctttcgc catgaccttc ttcagcctgg ccacgatgct catgctcttc

541 gccatggccc tggagcgcta cctctcgatc gggcacccct acttctacca gcgccgcgtc

601 tcggcctccg ggggcctggc cgtgctgcct gtcatctatg cagtctccct gctcttctgc

661 tcgctgccgc tgctggacta tgggcagtac gtccagtact gccccgggac ctggtgcttc

721 atccggcacg ggcggaccgc ttacctgcag ctgtacgcca ccctgctgct gcttctcatt

781 gtctcggtgc tcgcctgcaa cttcagtgtc attctcaacc tcatccgcat gcaccgccga

841 agccggagaa gccgctgcgg accttccctg ggcagtggcc ggggcggccc cggggcccgc

901 aggagagggg aaagggtgtc catggcggag gagacggacc acctcattct cctggctatc

961 atgaccatca ccttcgccgt ctgctccttg cctttcacga tttttgcata tatgaatgaa

1021 acctcttccc gaaaggaaaa atgggacctc caagctctta ggtttttatc aattaattca

1081 ataattgacc cttgggtctt tgccatcctt aggcctcctg ttctgagact aatgcgttca

1141 gtcctctgtt gtcggatttc attaagaaca caagatgcaa cacaaacttc ctgttctaca

1201 cagtcagatg ccagtaaaca ggctgacctt tgaggtcagt agtttaaaag ttcttagtta

1261 tatagcatct ggaagatcat tttgaaattg ttccctggag aaatgaaaac agtgtgtaaa

1321 caaaatgaag ctgccctaat aaaaaggagt atacaaacat ttaagctgtg gtcaaggcta

1381 cagatgtgct gacaaggcac ttcatgtaaa gtgtcagaag gagctacaaa acctaccctc

1441 aatgagcatg gtacttggcc tttggaggaa caatcggctg cattgaagat ccagctgcct

1501 attgatttaa gctttcctgt tgaatgacaa agtatgtggt tttgtaattt gtttgaaacc

1561 ccaaacagtg actgtacttt ctattttaat cttgctacta ccgttataca catatagtgt

1621 acagccagac cagattaaac ttcatatgta atctctagga agtcaatatg tggaagcaac

1681 caagcctgct gtcttgtgat cacttagcga accctttatt tgaacaatga agttgaaaat

1741 cataggcacc ttttactgtg atgtttgtgt atgtgggagt actctcatca ctacagtatt

1801 actcttacaa gagtggactc agtgggttaa catcagtttt gtttactcat cctccaggaa

1861 ctgcaggtca agttgtcagg ttatttattt tataatgtcc atatgctaat agtgatcaag

1921 aagactttag gaatggttct ctcaacaaga aataatagaa atgtctcaag gcagttaatt

1981 ctcattaata ctcttattat cctatttctg ggggaggatg tacgtggcca tgtatgaagc

2041 caaatattag gcttaaaaac tgaaaaatct ggttcattct tcagatatac tggaaccctt

2101 ttaaagttga tattggggcc atgagtaaaa tagattttat aagatgactg tgttgtacca

2161 aaattcatct gtctatattt tatttagggg aacatggttt gactcatctt atatgggaaa

2221 ccatgtagca gtgagtcata tcttaatata tttctaaatg tttggcatgt aaatgtaaac

2281 tcagcatcaa aatatttcag tgaatttgca ctgtttaatc atagttactg tgtaaactca

2341 tctgaaatgt tacaaaaata aactataaaa ca

L agagaggaag gcgtggctcc ctcccgggcc agtgagccct ggcgccgccg cggccgcggt

61 cccagcagcg gagtagggcg gcggctgcgc cccgcaccat ggggggcagc ccagccccag

121 ccgcggtaaa cgccgacctc cgccgccgcc cgcgccgcgt ctgccccctc ccgctgcggc

181 tctctggacg ccatcccctc ctcacctcga agccaacatg aaggagaccc ggggctacgg

241 aggggatgcc cccttctgca cccgcctcaa ccactcctac acaggcatgt gggcgcccga

301 gcgttccgcc gaggcgcggg gcaacctcac gcgccctcca gggtctggcg aggattgcgg

361 atcggtgtcc gtggccttcc cgatcaccat gctgctcact ggtttcgtgg gcaacgcact

421 ggccatgctg ctcgtgtcgc gcagctaccg gcgccgggag agcaagcgca agaagtcctt

481 cctgctgtgc atcggctggc tggcgctcac cgacctggtc gggcagcttc tcaccacccc

541 ggtcgtcatc gtcgtgtacc tgtccaagca gcgttgggag cacatcgacc cgtcggggcg

601 gctctgcacc tttttcgggc tgaccatgac tgttttcggg ctctcctcgt tgttcatcgc

661 cagcgccatg gccgtcgagc gggcgctggc catcagggcg ccgcactggt atgcgagcca

721 catgaagacg cgtgccaccc gcgctgtgct gctcggcgtg tggctggccg tgctcgcctt

781 cgccctgctg ccggtgctgg gcgtgggcca gtacaccgtc cagtggcccg ggacgtggtg

841 cttcatcagc accgggcgag ggggcaacgg gactagctct tcgcataact ggggcaacct

901 tttcttcgcc tctgcctttg ccttcctggg gctcttggcg ctgacagtca ccttttcctg

961 caacctggcc accattaagg ccctggtgtc ccgctgccgg gccaaggcca cggcatctca

1021 gtccagtgcc cagtggggcc gcatcacgac cgagacggcc attcagctta tggggatcat

1081 gtgcgtgctg tcggtctgct ggtctccgct cctgataatg atgttgaaaa tgatcttcaa

1141 tcagacatca gttgagcact gcaagacaca cacggagaag cagaaagaat gcaacttctt

1201 cttaatagct gttcgcctgg cttcactgaa ccagatcttg gatccttggg tttacctgct

1261 ^■gttaagaaag atccttcttc gaaagttttg ccaggtagca aatgctgtct ccagctgctc

1321 taatgatgga cagaaagggc agcctatctc attatctaat gaaataatac agacagaagc

1381 atgaaagaaa acacttaact tgcatgtgca cagcttctgg taacaaatat cgctaaacct

1441 tactgtgaat ttaggcatct ctggcatgcc actgtttatg cattgaagtg gaatttttgg

1501 tataaagcta aatggtctta gaagcataga aaatccctat gtgccaaaag tagtgaaaca

1561 caaacaaagg aaaatatatt aataacagtc tagtgttttt gttgagtctg ccattcgtag

1621 ctgaatatgt gattaattat gtgatgaaaa ctttttttat aaatgatctt ggtctattgg 1681 gg

1 cccgggccac 1 tgagccctgg cgccgccgcg gccgcggtcc cagcagcgga gtagggcggc EPI-109 1066

61 ggctgcgccc cgcaccatgg ggggcagccc agccccagcc gcggtaaacg ccgacctccg

121 ccgccgcccg cgccgcgtct gccccctccc gctgcggctc tctggacgcc atcccctcct

181 cacctcgaag ccaacatgaa ggagacccgg ggctacggag gggatgcccc cttctgcacc

241 cgcctcaacc actcctacac aggcatgtgg gcgcccgagc gttccgccga ggcgcggggc

301 aacctcacgc gccctccagg gtctggcgag gattgcggat cggtgtccgt ggccttcccg

361 atcaccatgc tgctcactgg tttcgtgggc aacgcactgg ccatgctgct cgtgtcgcgc

421 agctaccggc gccgggagag caagcgcaag aagtccttcc tgctgtgcat cggctggctg

481 gcgctcaccg acctggtcgg gcagcttctc accaccccgg tcgtcatcgt cgtgtacctg

541 tccaagcagc gttgggagca catcgacccg tcggggcggc tctgcacctt tttcgggctg

601 accatgactg ttttcgggct ctcctcgttg ttcatcgcca gcgccatggc cgtcgagcgg

661 gcgctggcca tcagggcgcc gcactggtat gcgagccaca tgaagacgcg tgccacccgc

721 gctgtgctgc tcggcgtgtg gctggccgtg ctcgccttcg ccctgctgcc ggtgctgggc

781 gtgggccagt acaccgtcca gtggcccggg acgtggtgct tcatcagcac cgggcgaggg

841 ggcaacggga ctagctcttc gcataactgg ggcaaccttt tcttcgcctc tgcctttgcc

901 ttcctggggc tcttggcgct gacagtcacc ttttcctgca acctggccac cattaaggcc

961 ctggtgtccc gctgccgggc caaggccacg gcatctcagt ccagtgccca gtggggccgc

1021 atcacgaccg agacggccat tcagcttatg gggatcatgt gcgtgctgtc ggtctgctgg

1081 tctccgctcc tgataatgat gttgaaaatg atcttcaatc agacatcagt tgagcactgc

1141 aagacacaca cggagaagca gaaagaatgc aacttcttct taatagctgt tcgcctggct

1201 tcactgaacc agatcttgga tccttgggtt tacctgctgt taagaaagat ccttcttcga

1261 aagttttgcc agatcaggta ccacacaaac aactatgcat ccagctccac ctccttaccc

1321 tgccagtgtt cctcaacctt gatgtggagc gaccatttgg aaagataatg aaagaacgga

1381 gttggacatt ttattgcaat tcctgcttcc ctgaatttgc atatttcttc ccacctgaga

1441 aggataatta tatattttaa tttggattat ttcttcattt ttatcttttt attttaatga

1501 ttgttttgtc agtaataccc atggagatca actttattat tataatccat gcctctgaat

1561 attagattgg tttcttggat gggattttga atatgcattt aagaagttgg gaagaatttc

1621 acagatgatg attggaggaa aagtgatgaa aagaaagacc tgtgttccag gagttttctc

1681 caacttcaaa cctttacgtg aatcttaacc aaagtggaca tctttacatt tcatgatagc

1741 ttgcttttgc aatatgagtt tgaaaaatca gtataagctt atgatggtga aaagtcaaca

1801 tattgagagt gataattcaa ttaataggat atgaacttaa cgatataaaa gcaaatgagg

1861 gcaggagggg

1 agagaggaag gcgtggctcc ctcccgggcc agtgagccct ggcgccgccg cggccgcggt

61 cccagcagcg gagtagggcg gcggctgcgc cccgcaccat ggggggcagc ccagccccag

121 ccgcggtaaa cgccgacctc cgccgccgcc cgcgccgcgt ctgccccctc ccgctgcggc

181 tctctggacg ccatcccctc ctcacctcga agccaacatg aaggagaccc ggggctacgg

241 aggggatgcc cccttctgca cccgcctcaa ccactcctac acaggcatgt gggcgcccga

301 gcgttccgcc gaggcgcggg gcaacctcac gcgccctcca gggtctggcg aggattgcgg

361 atcggtgtcc gtggccttcc cgatcaccat gctgctcact ggtttcgtgg gcaacgcact

421 ggccatgctg ctcgtgtcgc gcagctaccg gcgccgggag agcaagcgca agaagtcctt

481 cctgctgtgc atcggctggc tggcgctcac cgacctggtc gggcagcttc tcaccacccc

541 ggtcgtcatc gtcgtgtacc tgtccaagca gcgttgggag cacatcgacc cgtcggggcg

601 gctctgcacc tttttcgggc tgaccatgac tgttttcggg ctctcctcgt tgttcatcgc

661 cagcgccatg gccgtcgagc gggcgctggc catcagggcg ccgcactggt atgcgagcca

721 catgaagacg cgtgccaccc gcgctgtgct gctcggcgtg tggctggccg tgctcgcctt

781 cgccctgctg ccggtgctgg gcgtgggcca gtacaccgtc cagtggcccg ggacgtggtg

841 cttcatcagc accgggcgag ggggcaacgg gactagctct tcgcataact ggggcaacct

901 tttcttcgcc tctgcctttg ccttcctggg gctcttggcg ctgacagtca ccttttcctg

961 caacctggcc accattaagg ccctggtgtc ccgctgccgg gccaaggcca cggcatctca

1021 gtccagtgcc cagtggggcc gcatcacgac cgagacggcc attcagctta tggggatcat

1081 gtgcgtgctg tcggtctgct ggtctccgct cctgataatg atgttgaaaa tgatcttcaa

1141 tcagacatca gttgagcact gcaagacaca cacggagaag cagaaagaat gcaacttctt

1201 cttaatagct gttcgcctgg cttcactgaa ccagatcttg gatccttggg tttacctgct

1261 gttaagaaag atccttcttc gaaagttttg ccaggtagca aatgctgtct ccagctgctc

1321 taatgatgga cagaaagggc agcctatctc attatctaat gaaataatac agacagaagc

1381 atgaaagaaa acacttaact tgcatgtgca cagcttctgg taacaaatat cgctaaacct

1441 tactgtgaat ttaggcatct ctggcatgcc actgtttatg cattgaagtg gaatttttgg

1501 tataaagcta aatggtctta gaagcataga aaatccctat gtgccaaaag tagtgaaaca

1561 caaacaaagg aaaatatatt aataacagtc tagtgttttt gttgagtctg ccattcgtag

1621 ctgaatatgt gattaattat gtgatgaaaa ctttttttat aaatgatctt ggtctattgg

1681 gg

1 agagaggaag gcgtggctcc ctcccgggcc agtgagccct ggcgccgccg cggccgcggt

61 cccagcagcg gagtagggcg gcggctgcgc cccgcaccat ggggggcagc ccagccccag

121 ccgcggtaaa cgccgacctc cgccgccgcc cgcgccgcgt ctgccccctc ccgctgcggc

181 tctctggacg ccatcccctc ctcacctcga agccaacatg aaggagaccc ggggctacgg

241 aggggatgcc cccttctgca cccgcctcaa ccactcctac acaggcatgt gggcgcccga

301 gcgttccgcc gaggcgcggg gcaacctcac gcgccctcca gggtctggcg aggattgcgg

361 atcggtgtcc gtggccttcc cgatcaccat gctgctcact ggtttcgtgg gcaacgcact

421 ggccatgctg ctcgtgtcgc gcagctaccg gcgccgggag agcaagcgca agaagtcctt EPI-109 1067

481 cctgctgtgc atcggctggc tggcgctcac cgacctggtc gggcagcttc tcaccacccc

541 ggtcgtcatc gtcgtgtacc tgtccaagca gcgttgggag cacatcgacc cgtcggggcg

601 gctctgcacc tttttcgggc tgaccatgac tgttttcggg ctctcctcgt tgttcatcgc

661 cagcgccatg gccgtcgagc gggcgctggc catcagggcg ccgcactggt atgcgagcca

721 catgaagacg cgtgccaccc gcgctgtgct gctcggcgtg tggctggccg tgctcgcctt

781 cgccctgctg ccggtgctgg gcgtgggcca gtacaccgtc cagtggcccg ggacgtggtg

841 cttcatcagc accgggcgag ggggcaacgg gactagctct tcgcataact ggggcaacct

901 tttcttcgcc tctgcctttg ccttcctggg gctcttggcg ctgacagtca ccttttcctg

961 caacctggcc accattaagg ccctggtgtc ccgctgccgg gccaaggcca cggcatctca

1021 gtccagtgcc cagtggggcc gcatcacgac cgagacggcc attcagctta tggggatcat

1081 gtgcgtgctg tcggtctgct ggtctccgct cctgataatg atgttgaaaa tgatcttcaa

1141 tcagacatca gttgagcact gcaagacaca cacggagaag cagaaagaat gcaacttctt

1201 cttaatagct gttcgcctgg cttcactgaa ccagatcttg gatccttggg tttacctgct

1261 gttaagaaag atccttcttc gaaagttttg ccaggaggaa ttttggggaa attaaaacct

1321 gcctttctgc caggatcaca tcactggaag ctccatgact ctctttttgt aaaagaaaa

1 gtgcgcggag gggacgagcg gctggaccac agccggcgcc cgatcaggat ctccgcgctg

61 ggatcggtgg aacttgaggc agcggcggcg cggggcgcca tggcacaccg agcggctccg

121 tcttctgctc ctcagagagc ccggctggcg gcctgggatg acaagatgtc tggactgcaa

181 tcctgcacag ttttgagagg gagatgactt gagtggttgg cttttatctc cacaacaatg

241 tccatgaaca attccaaaca gctagtgtct cctgcagctg cgcttctttc aaacacaacc

301 tgccagacgg aaaaccggct ttccgtattt ttttcagtaa tcttcatgac agtgggaatc

361 ttgtcaaaca gccttgccat cgccattctc atgaaggcat atcagagatt tagacagaag

421 tccaaggcat cgtttctgct tttggccagc ggcctggtaa tcactgattt ctttggccat

481 ctcatcaatg gagccatagc agtatttgta tatgcttctg ataaagaatg gatccgcttt

541 gaccaatcaa atgtcctttg cagtattttt ggtatctgca tggtgttttc tggtctgtgc

601 ccacttcttc taggcagtgt gatggccatt gagcggtgta ttggagtcac aaaaccaata

661 tttcattcta cgaaaattac atccaaacat gtgaaaatga tgttaagtgg tgtgtgcttg

721 tttgctgttt tcatagcttt gctgcccatc cttggacatc gagactataa aattcaggcg

781 tcgaggacct ggtgtttcta caacacagaa gacatcaaag actgggaaga tagattttat

841 cttctacttt tttcttttct ggggctctta gcccttggtg tttcattgtt gtgcaatgca

901 atcacaggaa ttacactttt aagagttaaa tttaaaagtc agcagcacag acaaggcaga

961 tctcatcatt tggaaatggt aatccagctc ctggcgataa tgtgtgtctc ctgtatttgt

1021 tggagcccat ttctggttac aatggccaac attggaataa atggaaatca ttctctggaa

1081 acctgtgaaa caacactttt tgctctccga atggcaacat ggaatcaaat cttagatcct

1141 tgggtatata ttcttctacg aaaggctgtc cttaagaatc tctataagct tgccagtcaa

1201 tgctgtggag tgcatgtcat cagcttacat atttgggagc ttagttccat taaaaattcc

1261 ttaaaggttg ctgctatttc tgagtcacca gttgcagaga aatcagcaag cacctagctt

1321 aataggacag taaatctgtg tggggctaga acaaaaatta agacatgttt ggcaatattt

1381 cagttagtta aatacctgta gcctaactgg aaaattcagg cttcatcatg tagtttgaag

1441 atactattgt cagattcagg ttttgaaatt tgtcaaataa acaggataac tgtacatttt

1501 caacttgttt ttgccaatgg gaggtagaca caataaaata atgccatggg agtcacactg

1561 aaagcaattt tgagcttatc tgtcttattt atgctttgag tgaatcatct gttgaggtct

1621 aatgcctcta cttggcctat ttgccagaga acatcttaat gcagcctgca tagtgaaatg

1681 gttattttga gatcaccgct ctgtagctaa cccttataaa ctaggctcag taaaataaag

1741 cactcttatt ttttgatctg gcctattttg cccctcattg tgtagcctca attaacacat

1801 gcatggtcat gacacccaga attcatgatg gtttgttata acaacctctg catattccag

1861 gtctggcaga caggttgcct gaccctgcaa tcctatctag aatgggccca ttcttgtcac

1921 atttgacaaa taggactgcc tacatttatt attatgaagg tcgattgttg ttggaagtgt

1981 tttttcatgt catagattag caattttcaa ataattattt tttctctgaa aattttgtgt

2041 gtgattgcac aataaataat ttttagagaa acaaaggctc tttctcagca cattgatggg

2101 caactagaat tacagcagtt tcaaactcta ccatggataa tgcaaacaaa ccgaagctac

2161 atgccaatga taggtgcaaa gaatattggc aaaaggtgct ttaccttgag ccattatttg

2221 tgtcagagaa caaaagaaac agaatcaata tataaattca aagactatct gcagctagtg

2281 tgtttcttct ttacacacat atacacacag acatcagaaa attctgttga gagcaggttc

2341 attaaatttg taagatggca tattctaaag cctgtgctac cagtactaag aggggaagac

2401 tggcaatttg ccaagcactt ggggattatt ataacaatta actaggagat caagagataa

2461 taatctctcc ccaaattttc caataataat tgag

1 ggcacagacg cacgggacag gagagcctgg gcaagactgg agagcccaga cctgggatgg

61 cggattcgtg caggaacctc acctacgtgc ggggctcggt ggggccggcc accagcaccc

121 tgatgttcgt ggccggtgtg gtgggcaacg ggctggccct gggcatcctg agcgcacggc

181 gaccggcgcg cccctcggcc ttcgcggtgc tggtcaccgg actggcggcc accgacctgc

241 tgggcaccag cttcctgagc ccggccgtgt tcgtggccta tgcgcgcaac agctccctgc

301 tgggcctggc ccgaggcggc cccgccctgt gcgatgcctt cgccttcgcc atgaccttct

361 tcggcctggc gtccatgctc atcctctttg ccatggccgt ggagcgctgc ctggcgctga

421 gccaccccta cctctacgcg cagctggacg ggccccgctg cgcccgcctg gcgctgccag

481 ccatctacgc cttctgcgtc ctcttctgcg cgctgcccct gctgggcctg ggccaacacc

541 agcagtactg ccccggcagc tggtgcttcc tccgcatgcg ctgggcccag ccgggcggcg

601 ccgccttctc gctggcctac gccggcctgg tggccctgct ggtggctgcc atcttcctct EPI-109 1068

661 gcaacggctc ggtcaccctc agcctctgcc gcatgtaccg ccagcagaag cgccaccagg

721 gctctctggg tccacggccg cgcaccggag aggacgaggt ggaccacctg atcctgctgg

781 ccctcatgac agtggtcatg gccgtgtgct ccctgcctct cacgatccgc tgcttcaccc

841 aggctgtcgc ccctgacagc agcagtgaga tgggggacct ccttgccttc cgcttctacg

901 ccttcaaccc catcctggac ccctgggtct tcatcctttt ccgcaaggct gtcttccagc

961 gactcaagct ctgggtctgc tgcctgtgcc tcgggcctgc ccacggagac tcgcagacac

1021 ccctttccca gctcgcctcc gggaggaggg acccaagggc cccctctgct cctgtgggaa

1081 aggaggggag ctgcgtgcct ttgtcggctt ggggcgaggg gcaggtggag cccttgcctc

1141 ccacacagca gtccagcggc agcgccgtgg gaacgtcgtc caaagcagaa gccagcgtcg

1201 cctgctccct ctgctgacat ttcaagctga ccctgtgatc tctgccctgt cttcgggcga

1261 caggagccag aaaatcaggg acatggctga tggctgcgga tgctggaacc ttggccccca

1321 aactctgggg ccgatcagct gctgtttctc tgcggcaggg cagtcgctgc tggctctggg

1381 aagagagtga gggacagagg aaacgtttat cctggag

(2) INFORMATION FOR SEQ ID NO: 2803: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2803

1 gctttctcct agggactgtg aggggcgctt ctgactttgg acttgagcac tgcctgggac

61 ctgtgctgag agagcgctag catgtctcag tggaatcaag tccaacagtt agaaatcaag

121 tttttggagc aggtggatca attctatgat gacaactttc ccatggaaat tcggcatctg

181 ttggcccaat ggattgaaaa tcaagactgg gaggcagctt ctaacaatga aaccatggca

241 acgattcttc ttcaaaactt gttaatacaa ctggatgaac agttaggtcg tgtttccaaa

301 gagaaaaacc tactcttgat acacaatcta aaaagaatta ggaaggtcct tcagggaaaa

361 tttcatggaa atccaatgca tgtagctgtg gttatttcaa actgtttaag ggaagagagg

421 agaatattgg ctgcagccaa catgcctgtc caggggcctc tagagaaatc cttacaaagt

481 tcttcagttt cagaaagaca gaggaatgtg gagcacaaag tggctgccat taaaaacagt

541 gtgcagatga cagaacaaga taccaaatac ttagaagatc tgcaagacga atttgactac

601 aggtataaaa caattcagac aatggatcag agtgacaaga atagtgccat ggtgaatcag

661 gaagttttga cactgcagga aatgcttaac agcctcgatt tcaagagaaa ggaggctctc

721 agtaaaatga cccaaatcat ccatgagaca gacctgttaa tgaacaccat gctcatagaa

781 gagctgcaag actggaagcg gcggcagcaa atcgcctgca tcgggggtcc actccacaat

841 gggctcgacc agcttcagaa ctgctttaca ctattggcag aaagtctttt ccaactgaga

901 aggcaattgg agaaactaga ggagcaatct accaaaatga catatgaagg tgatcccatt

961 ccaatgcaaa gaactcacat gctagaaaga gtcaccttct tgatctacaa ccttttcaag

1021 aactcatttg tggttgagcg acagccatgt atgccaaccc accctcagag gccgttggta

1081 cttaaaaccc taattcagtt cactgtaaaa ctaaggctac taataaaatt gccagaacta

1141 aactatcagg taaaggttaa ggcatcaatt gacaagaatg tttcaactct aagcaaccga

1201 agatttgtac tttgtggaac taatgtcaaa gccatgtcta ttgaagaatc ttccaatggg

1261 agtctctcag tagaatttcg acatttgcaa ccaaaggaaa tgaagtccag tgctggaggt

1321 aaaggaaatg agggctgtca catggtgact gaagaacttc attccataac gtttgaaaca

1381 cagatctgcc tctatggcct gaccatagat ttggagacca gctcattgcc tgtggtgatg

1441 atttccaatg tcagtcagtt acctaatgct tgggcatcca tcatttggta caacgtgtca

1501 accaacgatt cccagaactt ggttttcttt aataatcctc cacctgccac attgagtcaa

1561 ctactggagg tgatgagctg gcagttttca tcgtacgttg gtcgtggtct taactcagat

1621 caactccata tgctggcaga gaagcttaca gtccaatcta gctacagtga tggtcacctc

1681 acctgggcca agttctgcaa ggaacattta cctggtaaat catttacctt ttggacatgg

1741 cttgaagcaa tattggatct aattaagaaa cacattcttc ccctttggat tgatgggtat

1801 gtcatgggct ttgttagcaa agagaaggaa cggctgttgc taaaggataa aatgcctggc

1861 acctttttat taagattcag tgaaagccat ctcggaggaa taactttcac ctgggtggac

1921 cattctgaaa gtggggaagt gagattccac tctgtagaac cctacaataa aggccggttg

1981 tctgctctgc cattcgctga catcctgcga gactacaaag ttattatggc tgaaaacatt

2041 cctgaaaacc ctctgaagta cctatatcct gacattccca aagacaaagc cttcggtaaa

2101 cactacagct ctcagccttg cgaagtttca agaccaacag aaaggggtga caaaggttat

2161 gttccttctg tttttatccc catctcaaca atccgaagtg attcaacaga gccacattct

2221 ccatcagacc ttcttcccat gtctccaagt gtgtatgcgg tgttgagaga aaacctgagt

2281 cccacaacaa ttgaaactgc aatgaagtct ccttattctg ctgaatgaca ggataaactc

2341 tgacgcacca agaaaggaag caaatgaaaa agtttaaaga ctgttctttg cccaataacc

2401 acattttatt tcttcagctt tgtaaatacc aggttctagg aaatgtttga catctgaagc

2461 tctcttcaca ctcccgtggc actcctcaat tgggagtgtt gtgactgaaa tgcttgaaac

2521 caaagcttca gataaacttg caagataaga caactttaag aaaccagtgt taataacaat

2581 attaacag

(2) INFORMATION FOR SEQ ID NO: 2804:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: base pairs EPI-109 1069

( B ) TYPE : nucleic acid

( C ) STRANDEDNESS : single

( D ) TOPOLOGY : linear ( xi ) SEQUENCE DESCRIPTION :

1 gctttctcct agggactgtg aggggcgctt ctgactttgg acttgagcac tgcctgggac

61 ctgtgctgag agagcgctag catgtctcag tggaatcaag tccaacagtt agaaatcaag

121 tttttggagc aggtggatca attctatgat gacaactttc ccatggaaat tcggcatctg

181 ttggcccaat ggattgaaaa tcaagactgg gaggcagctt ctaacaatga aaccatggca

241 acgattcttc ttcaaaactt gttaatacaa ctggatgaac agttaggtcg tgtttccaaa

301 gagaaaaacc tactcttgat acacaatcta aaaagaatta ggaaggtcct tcagggaaaa

361 tttcatggaa atccaatgca tgtagctgtg gttatttcaa actgtttaag ggaagagagg

421 agaatattgg ctgcagccaa catgcctgtc caggggcctc tagagaaatc cttacaaagt

481 tcttcagttt cagaaagaca gaggaatgtg gagcacaaag tggctgccat taaaaacagt

541 gtgcagatga cagaacaaga taccaaatac ttagaagatc tgcaagacga atttgactac

601 aggtataaaa caattcagac aatggatcag agtgacaaga atagtgccat ggtgaatcag

661 gaagttttga cactgcagga aatgcttaac agcctcgatt tcaagagaaa ggaggctctc

721 agtaaaatga cccaaatcat ccatgagaca gacctgttaa tgaacaccat gctcatagaa

781 gagctgcaag actggaagcg gcggcagcaa atcgcctgca tcgggggtcc actccacaat

841 gggctcgacc agcttcagaa ctgctttaca ctattggcag aaagtctttt ccaactgaga

901 aggcaattgg agaaactaga ggagcaatct accaaaatga catatgaagg tgatcccatt

961 ccaatgcaaa gaactcacat gctagaaaga gtcaccttct tgatctacaa ccttttcaag

1021 aactcatttg tggttgagcg acagccatgt atgccaaccc accctcagag gccgttggta

1081 cttaaaaccc taattcagtt cactgtaaaa ctaaggctac taataaaatt gccagaacta

1141 aactatcagg taaaggttaa ggcatcaatt gacaagaatg tttcaactct aagcaaccga

1201 agatttgtac tttgtggaac taatgtcaaa gccatgtcta ttgaagaatc ttccaatggg

1261 agtctctcag tagaatttcg acatttgcaa ccaaaggaaa tgaagtccag tgctggaggt

1321 aaaggaaatg agggctgtca catggtgact gaagaacttc attccataac gtttgaaaca

1381 cagatctgcc tctatggcct gaccatagat ttggagacca gctcattgcc tgtggtgatg

1441 atttccaatg tcagtcagtt acctaatgct tgggcatcca tcatttggta caacgtgtca

1501 accaacgatt cccagaactt ggttttcttt aataatcctc cacctgccac attgagtcaa

1561 ctactggagg tgatgagctg gcagttttca tcgtacgttg gtcgtggtct taactcagat

1621 caactccata tgctggcaga gaagcttaca gtccaatcta gctacagtga tggtcacctc

1681 acctgggcca agttctgcaa ggaacattta cctggtaaat catttacctt ttggacatgg

1741 cttgaagcaa tattggatct aattaagaaa cacattcttc ccctttggat tgatgggtat

1801 gtcatgggct ttgttagcaa agagaaggaa cggctgttgc taaaggataa aatgcctggc

1861 acctttttat taagattcag tgaaagccat ctcggaggaa taactttcac ctgggtggac

1921 cattctgaaa gtggggaagt gagattccac tctgtagaac cctacaataa aggccggttg

1981 tctgctctgc cattcgctga catcctgcga gactacaaag ttattatggc tgaaaacatt

2041 cctgaaaacc ctctgaagta cctatatcct gacattccca aagacaaagc cttcggtaaa

2101 cactacagct ctcagccttg cgaagtttca agaccaacag aaaggggtga caaaggttat

2161 gttccttctg tttttatccc catctcaaca atccgaagtg attcaacaga gccacattct

2221 ccatcagacc ttcttcccat gtctccaagt gtgtatgcgg tgttgagaga aaacctgagt

2281 cccacaacaa ttgaaactgc aatgaagtct ccttattctg ctgaatgaca ggataaactc

2341 tgacgcacca agaaaggaag caaatgaaaa agtttaaaga ctgttctttg cccaataacc

2401 acattttatt tcttcagctt tgtaaatacc aggttctagg aaatgtttga catctgaagc

2461 tctcttcaca ctcccgtggc actcctcaat tgggagtgtt gtgactgaaa tgcttgaaac

2521 caaagcttca gataaacttg caagataaga caactttaag aaaccagtgt taataacaat

2581 attaacag

(2) INFORMATION FOR SEQ ID NO: 2805:

( i : 1 SEQUENCE CHARACTERISTICS:

(A) LENGTH: base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2805

1 atcttatttt tctttttggt ggtggtggtg gaagggggga ggtgctagca gggccagcct

61 tgaactcgct ggacagagct acagacctat ggggcctgga agtgcccgct gagaaaggga

121 gaagacagca gaggggttgc cgaggcaacc tccaagtccc agatcatgtc tctgtggggt

181 ctggtctcca agatgccccc agaaaaagtg cagcggctct atgtcgactt tccccaacac

241 ctgcggcatc ttctgggtga ctggctggag agccagccct gggagttcct ggtcggctcc

301 gacgccttct gctgcaactt ggctagtgcc ctactttcag acactgtcca gcaccttcag

361 gcctcggtgg gagagcagg ggaggggagc accatcttgc aacacatcag cacccttgag

421 agcatatatc agagggaccc cctgaagctg gtggccactt tcagacaaat acttcaagga

481 gagaaaaaag ctgttatgga acagttccgc cacttgccaa tgcctttcca ctggaagcag

541 gaagaactca agtttaagac aggcttgcgg aggctgcagc accgagtagg ggagatccac

601 cttctccgag aagccctgca gaagggggct gaggctggcc aagtgtctct gcacagcttg

661 atagaaactc ctgctaatgg gactgggcca agtgaggccc tggccatgct actgcaggag

721 accactggag agctagaggc agccaaagcc ctagtgctga agaggatcca gatttggaaa EPI-109 1070

781 cggcagcagc agctggcagg gaatggcgca ccgtttgagg agagcctggc cccactccag

841 gagaggtgtg aaagcctggt ggacatttat tcccagctac agcaggaggt aggggcggct

901 ggtggggagc ttgagcccaa gacccgggca tcgctgactg gccggctgga tgaagtcctg

961 agaaccctcg tcaccagttg cttcctggtg gagaagcagc ccccccaggt actgaagact

1021 cagaccaagt tccaggctgg agttcgattc ctgttgggct tgaggttcct gggggcccca

1081 gccaagcctc cgctggtcag ggccgacatg gtgacagaga agcaggcgcg ggagctgagt

1141 gtgcctcagg gtcctggggc tggagcagaa agcactggag aaatcatcaa caacactgtg

1201 cccttggaga acagcattcc tgggaactgc tgctctgccc tgttcaagaa cctgcttctc

1261 aagaagatca agcggtgtga gcggaagggc actgagtctg tcacagagga gaagtgcgct

1321 gtgctcttct ctgccagctt cacacttggc cccggcaaac tccccatcca gctccaggcc

1381 ctgtctctgc ccctggtggt catcgtccat ggcaaccaag acaacaatgc caaagccact

1441 atcctgtggg acaatgcctt ctctgagatg gaccgcgtgc cctttgtggt ggctgagcgg

1501 gtgccctggg agaagatgtg tgaaactctg aacctgaagt tcatggctga ggtggggacc

1561 aaccgggggc tgctcccaga gcacttcctc ttcctggccc agaagatctt caatgacaac

1621 agcctcagta tggaggcctt ccagcaccgt tctgtgtcct ggtcgcagtt caacaaggag

1681 atcctgctgg gccgtggctt caccttttgg cagtggtttg atggtgtcct ggacctcacc

1741 aaacgctgtc tccggagcta ctggtctgac cggctgatca ttggcttcat cagcaaacag

1801 tacgttacta gccttcttct caatgagccc gacggaacct ttctcctccg cttcagcgac

1861 tcagagattg ggggcatcac cattgcccat gtcatccggg gccaggatgg ctctccacag

1921 atagagaaca tccagccatt ctctgccaaa gacctgtcca ttcgctcact gggggaccga

1981 atccgggatc ttgctcagct caaaaatctc tatcccaaga agcccaagga tgaggctttc

2041 cggagccact acaagcctga acagatgggt aaggatggca ggggttatgt cccagctacc

2101 atcaagatga ccgtggaaag ggaccaacca cttcctaccc cagagctcca gatgcctacc

2161 atggtgcctt cttatgacct tggaatggcc cctgattcct ccatgagcat gcagcttggc

2221 ccagatatgg tgccccaggt gtacccacca cactctcact ccatcccccc gtatcaaggc

2281 ctctccccag aagaatcagt caacgtgttg tcagccttcc aggagcctca cctgcagatg

2341 ccccccagcc tgggccagat gagcctgccc tttgaccagc ctcaccccca gggcctgctg

2401 ccgtgccagc ctcaggagca tgctgtgtcc agccctgacc ccctgctctg ctcagatgtg

2461 accatggtgg aagacagctg cctgagccag ccagtgacag cgtttcctca gggcacttgg

2521 attggtgaag acatattccc tcctctgctg cctcccactg aacaggacct cactaagctt

2581 ctcctggagg ggcaagggga gtcgggggga gggtccttgg gggcacagcc cctcctgcag

2641 ccctcccact atgggcaatc tgggatctca atgtcccaca tggacctaag ggccaacccc

2701 agttggtgat cccagctgga gggagaaccc aaagagacag ctcttctact acccccacag

2761 acctgctctg gacacttgct catgccctgc caagcagcag atggggaggg tgccctccta

2821 tccccaccta ctcctgggtc aggaggaaaa gactaacagg agaatgcaca gtgggtggag

2881 ccaatccact ccttcctttc tatcattccc ctgcccacct ccttccagca ctgactggaa

2941 gggaagttca ggctctgaga cacgccccaa catgcctgca cctgcagcgc gcacacgcac

3001 gcacacacac atacagagct ctctgagggt gatggggctg agcagg

(2) INFORMATION FOR SEQ ID NO:2806: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear ^•

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2806

1 gctttctcct agggactgtg aggggcgctt ctgactttgg acttgagcac tgcctgggac

61 ctgtgctgag agagcgctag catgtctcag tggaatcaag tccaacagtt agaaatcaag

121 tttttggagc aggtggatca attctatgat gacaactttc ccatggaaat tcggcatctg

181 ttggcccaat ggattgaaaa tcaagactgg gaggcagctt ctaacaatga aaccatggca

241 acgattcttc ttcaaaactt gttaatacaa ctggatgaac agttaggtcg tgtttccaaa

301 gagaaaaacc tactcttgat acacaatcta aaaagaatta ggaaggtcct tcagggaaaa

361 tttcatggaa atccaatgca tgtagctgtg gttatttcaa actgtttaag ggaagagagg

421 agaatattgg ctgcagccaa catgcctgtc caggggcctc tagagaaatc cttacaaagt

481 tcttcagttt cagaaagaca gaggaatgtg gagcacaaag tggctgccat taaaaacagt

541 gtgcagatga cagaacaaga taccaaatac ttagaagatc tgcaagacga atttgactac

601 aggtataaaa caattcagac aatggatcag agtgacaaga atagtgccat ggtgaatcag

661 gaagttttga cactgcagga aatgcttaac agcctcgatt tcaagagaaa ggaggctctc

721 agtaaaatga cccaaatcat ccatgagaca gacctgttaa tgaacaccat gctcatagaa

781 gagctgcaag actggaagcg gcggcagcaa atcgcctgca tcgggggtcc actccacaat

841 gggctcgacc agcttcagaa ctgctttaca ctattggcag aaagtctttt ccaactgaga

901 aggcaattgg agaaactaga ggagcaatct accaaaatga catatgaagg tgatcccatt

961 ccaatgcaaa gaactcacat gctagaaaga gtcaccttct tgatctacaa ccttttcaag

1021 aactcatttg tggttgagcg acagccatgt atgccaaccc accctcagag gccgttggta

1081 cttaaaaccc taattcagtt cactgtaaaa ctaaggctac taataaaatt gccagaacta

1141 aactatcagg taaaggttaa ggcatcaatt gacaagaatg tttcaactct aagcaaccga

1201 agatttgtac tttgtggaac taatgtcaaa gccatgtcta ttgaagaatc ttccaatggg

1261 agtctctcag tagaatttcg acatttgcaa ccaaaggaaa tgaagtccag tgctggaggt

1321 aaaggaaatg agggctgtca catggtgact gaagaacttc attccataac gtttgaaaca EPI-109 1071

1381 cagatctgcc tctatggcct gaccatagat ttggagacca gctcattgcc tgtggtgatg

1441 atttccaatg tcagtcagtt acctaatgct tgggcatcca tcatttggta caacgtgtca

1501 accaacgatt cccagaactt ggttttcttt aataatcctc cacctgccac attgagtcaa

1561 ctactggagg tgatgagctg gcagttttca tcgtacgttg gtcgtggtct taactcagat

1621 caactccata tgctggcaga gaagcttaca gtccaatcta gctacagtga tggtcacctc

1681 acctgggcca agttctgcaa ggaacattta cctggtaaat catttacctt ttggacatgg

1741 cttgaagcaa tattggatct aattaagaaa cacattcttc ccctttggat tgatgggtat

1801 gtcatgggct ttgttagcaa agagaaggaa cggctgttgc taaaggataa aatgcctggc

1861 acctttttat taagattcag tgaaagccat ctcggaggaa taactttcac ctgggtggac

1921 cattctgaaa gtggggaagt gagattccac tctgtagaac cctacaataa aggccggttg

1981 tctgctctgc cattcgctga catcctgcga gactacaaag ttattatggc tgaaaacatt

2041 cctgaaaacc ctctgaagta cctatatcct gacattccca aagacaaagc cttcggtaaa

2101 cactacagct ctcagccttg cgaagtttca agaccaacag aaaggggtga caaaggttat

2161 gttccttctg tttttatccc catctcaaca atccgaagtg attcaacaga gccacattct

2221 ccatcagacc ttcttcccat gtctccaagt gtgtatgcgg tgttgagaga aaacctgagt

2281 cccacaacaa ttgaaactgc aatgaagtct ccttattctg ctgaatgaca ggataaactc

2341 tgacgcacca agaaaggaag caaatgaaaa agtttaaaga ctgttctttg cccaataacc

2401 acattttatt tcttcagctt tgtaaatacc aggttctagg aaatgtttga catctgaagc

2461 tctcttcaca ctcccgtggc actcctcaat tgggagtgtt gtgactgaaa tgcttgaaac

2521 caaagcttca gataaacttg caagataaga caactttaag aaaccagtgt taataacaat

2581 attaacag

1 gctttctcct agggactgtg aggggcgctt ctgactttgg acttgagcac tgcctgggac

61 ctgtgctgag agagcgctag catgtctcag tggaatcaag tccaacagtt agaaatcaag

121 tttttggagc aggtggatca attctatgat gacaactttc ccatggaaat tcggcatctg

181 ttggcccaat ggattgaaaa tcaagactgg gaggcagctt ctaacaatga aaccatggca

241 acgattcttc ttcaaaactt gttaatacaa ctggatgaac agttaggtcg tgtttccaaa

301 gagaaaaacc tactcttgat acacaatcta aaaagaatta ggaaggtcct tcagggaaaa

361 tttcatggaa atccaatgca tgtagctgtg gttatttcaa actgtttaag ggaagagagg

421 agaatattgg ctgcagccaa catgcctgtc caggggcctc tagagaaatc cttacaaagt

481 tcttcagttt cagaaagaca gaggaatgtg gagcacaaag tggctgccat taaaaacagt

541 gtgcagatga cagaacaaga taccaaatac ttagaagatc tgcaagacga atttgactac

601 aggtataaaa caattcagac aatggatcag agtgacaaga atagtgccat ggtgaatcag

661 gaagttttga cactgcagga aatgcttaac agcctcgatt tcaagagaaa ggaggctctc

721 agtaaaatga cccaaatcat ccatgagaca gacctgttaa tgaacaccat gctcatagaa

781 gagctgcaag actggaagcg gcggcagcaa atcgcctgca tcgggggtcc actccacaat

841 gggctcgacc agcttcagaa ctgctttaca ctattggcag aaagtctttt ccaactgaga

901 aggcaattgg agaaactaga ggagcaatct accaaaatga catatgaagg tgatcccatt

961 ccaatgcaaa gaactcacat gctagaaaga gtcaccttct tgatctacaa ccttttcaag

1021 aactcatttg tggttgagcg acagccatgt atgccaaccc accctcagag gccgttggta

1081 cttaaaaccc taattcagtt cactgtaaaa ctaaggctac taataaaatt gccagaacta

1141 aactatcagg taaaggttaa ggcatcaatt gacaagaatg tttcaactct aagcaaccga

1201 agatttgtac tttgtggaac taatgtcaaa gccatgtcta ttgaagaatc ttccaatggg

1261 agtctctcag tagaatttcg acatttgcaa ccaaaggaaa tgaagtccag tgctggaggt

1321 aaaggaaatg agggctgtca catggtgact gaagaacttc attccataac gtttgaaaca

1381 cagatctgcc tctatggcct gaccatagat ttggagacca gctcattgcc tgtggtgatg

1441 atttccaatg tcagtcagtt acctaatgct tgggcatcca tcatttggta caacgtgtca

1501 accaacgatt cccagaactt ggttttcttt aataatcctc cacctgccac attgagtcaa

1561 ctactggagg tgatgagctg gcagttttca tcgtacgttg gtcgtggtct taactcagat

1621 caactccata tgctggcaga gaagcttaca gtccaatcta gctacagtga tggtcacctc

1681 acctgggcca agttctgcaa ggaacattta cctggtaaat catttacctt ttggacatgg

1741 cttgaagcaa tattggatct aattaagaaa cacattcttc ccctttggat tgatgggtat

1801 gtcatgggct ttgttagcaa agagaaggaa cggctgttgc taaaggataa aatgcctggc

1861 acctttttat taagattcag tgaaagccat ctcggaggaa taactttcac ctgggtggac

1921 cattctgaaa gtggggaagt gagattccac tctgtagaac cctacaataa aggccggttg

1981 tctgctctgc cattcgctga catcctgcga gactacaaag ttattatggc tgaaaacatt

2041 cctgaaaacc ctctgaagta cctatatcct gacattccca aagacaaagc cttcggtaaa

2101 cactacagct ctcagccttg cgaagtttca agaccaacag aaaggggtga caaaggttat

2161 gttccttctg tttttatccc catctcaaca atccgaagtg attcaacaga gccacattct

2221 ccatcagacc ttcttcccat gtctccaagt gtgtatgcgg tgttgagaga aaacctgagt

2281 cccacaacaa ttgaaactgc aatgaagtct ccttattctg ctgaatgaca ggataaactc

2341 tgacgcacca agaaaggaag caaatgaaaa agtttaaaga ctgttctttg cccaataacc

2401 acattttatt tcttcagctt tgtaaatacc aggttctagg aaatgtttga catctgaagc

2461 tctcttcaca ctcccgtggc actcctcaat tgggagtgtt gtgactgaaa tgcttgaaac

2521 caaagcttca gataaacttg caagataaga caactttaag aaaccagtgt taataacaat

2581 attaacag

1 atcttatttt tctttttggt ggtggtggtg gaagggggga ggtgctagca gggccagcct

61 tgaactcgct ggacagagct acagacctat ggggcctgga agtgcccgct gagaaaggga

121 gaagacagca gaggggttgc cgaggcaacc tccaagtccc agatcatgtc tctgtggggt EPI-109 1072

181 ctggtctcca agatgccccc agaaaaagtg cagcggctct atgtcgactt tccccaacac

241 ctgcggcatc ttctgggtga ctggctggag agccagccct gggagttcct ggtcggctcc

301 gacgccttct gctgcaactt ggctagtgcc ctactttcag acactgtcca gcaccttcag

361 gcctcggtgg gagagcaggg ggaggggagc accatcttgc aacacatcag cacccttgag

421 agcatatatc agagggaccc cctgaagctg gtggccactt tcagacaaat acttcaagga

481 gagaaaaaag ctgttatgga acagttccgc cacttgccaa tgcctttcca ctggaagcag

541 gaagaactca agtttaagac aggcttgcgg aggctgcagc accgagtagg ggagatccac

601 cttctccgag aagccctgca gaagggggct gaggctggcc aagtgtctct gcacagcttg

661 atagaaactc ctgctaatgg gactgggcca agtgaggccc tggccatgct actgcaggag

721 accactggag agctagaggc agccaaagcc ctagtgctga agaggatcca gatttggaaa

781 cggcagcagc agctggcagg gaatggcgca ccgtttgagg agagcctggc cccactccag

841 gagaggtgtg aaagcctggt ggacatttat tcccagctac agcaggaggt aggggcggct

901 ggtggggagc ttgagcccaa gacccgggca tcgctgactg gccggctgga tgaagtcctg

961 agaaccctcg tcaccagttg cttcctggtg gagaagcagc ccccccaggt actgaagact

1021 cagaccaagt tccaggctgg agttcgattc ctgttgggct tgaggttcct gggggcccca

1081 gccaagcctc cgctggtcag ggccgacatg gtgacagaga agcaggcgcg ggagctgagt

1141 gtgcctcagg gtcctggggc tggagcagaa agcactggag aaatcatcaa caacactgtg

1201 cccttggaga acagcattcc tgggaactgc tgctctgccc tgttcaagaa cctgcttctc

1261 aagaagatca agcggtgtga gcggaagggc actgagtctg tcacagagga gaagtgcgct

1321 gtgctcttct ctgccagctt cacacttggc cccggcaaac tccccatcca gctccaggcc

1381 ctgtctctgc ccctggtggt catcgtccat ggcaaccaag acaacaatgc caaagccact

1441 atcctgtggg acaatgcctt ctctgagatg gaccgcgtgc cctttgtggt ggctgagcgg

1501 gtgccctggg agaagatgtg tgaaactctg aacctgaagt tcatggctga ggtggggacc

1561 aaccgggggc tgctcccaga gcacttcctc ttcctggccc agaagatctt caatgacaac

1621 agcctcagta tggaggcctt ccagcaccgt tctgtgtcct ggtcgcagtt caacaaggag

1681 atcctgctgg gccgtggctt caccttttgg cagtggtttg atggtgtcct ggacctcacc

1741 aaacgctgtc tccggagcta ctggtctgac cggctgatca ttggcttcat cagcaaacag

1801 tacgttacta gccttcttct caatgagccc gacggaacct ttctcctccg cttcagcgac

1861 tcagagattg ggggcatcac cattgcccat gtcatccggg gccaggatgg ctctccacag

1921 atagagaaca tccagccatt ctctgccaaa gacctgtcca ttcgctcact gggggaccga

1981 atccgggatc ttgctcagct caaaaatctc tatcccaaga agcccaagga tgaggctttc

2041 cggagccact acaagcctga acagatgggt aaggatggca ggggttatgt cccagctacc

2101 atcaagatga ccgtggaaag ggaccaacca cttcctaccc cagagctcca gatgcctacc

2161 atggtgcctt cttatgacct tggaatggcc cctgattcct ccatgagcat gcagcttggc

2221 ccagatatgg tgccccaggt gtacccacca cactctcact ccatcccccc gtatcaaggc

2281 ctctccccag aagaatcagt caacgtgttg tcagccttcc aggagcctca cctgcagatg

2341 ccccccagcc tgggccagat gagcctgccc tttgaccagc ctcaccccca gggcctgctg

2401 ccgtgccagc ctcaggagca tgctgtgtcc agccctgacc ccctgctctg ctcagatgtg

2461 accatggtgg aagacagctg cctgagccag ccagtgacag cgtttcctca gggcacttgg

2521 attggtgaag acatattccc tcctctgctg cctcccactg aacaggacct cactaagctt

2581 ctcctggagg ggcaagggga gtcgggggga gggtccttgg gggcacagcc cctcctgcag

2641 ccctcccact atgggcaatc tgggatctca atgtcccaca tggacctaag ggccaacccc

2701 agttggtgat cccagctgga gggagaaccc aaagagacag ctcttctact acccccacag

2761 acctgctctg gacacttgct catgccctgc caagcagcag atggggaggg tgccctccta

2821 tccccaccta ctcctgggtc aggaggaaaa gactaacagg agaatgcaca gtgggtggag

2881 ccaatccact ccttcctttc tatcattccc ctgcccacct ccttccagca ctgactggaa

2941 gggaagttca ggctctgaga cacgccccaa catgcctgca cctgcagcgc gcacacgcac

3001 gcacacacac atacagagct ctctgagggt gatggggctg agcagg

(2) INFORMATION FOR SEQ ID NO: 2807: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2807

1 tttattttta atttaatcac ttaattttta atttttaaga tggagtctca ctctgttgcc

61 caggctgaag tgcaagggtg taatctcagc tcactgcagc ctctgcctcc cggattccag

121 tgattttcct gcttcagctt cccaggtagc tgggattgca ggcacatgcc actgtgccca

181 gataattttt tgtattttt.t agtagagacg gggcttcacc atgttggcca ggctggtctt

241 gaactcctaa cctcagatga tccgcacacc tcggcctccc aaagtgctag gattacaggc

301 atgagcctct gcgcctggcc tttacttcag tttcaaagag tgaaggtcaa gacactgttt

361 ttttttatgt tttgttttta attttgtttt aaattttttt tgtagagatg ggatcttgct

421 atgttgccca ggctggtctc gaactcctgg cctccagcaa tcctcctgcc tcagcctccc

481 agagtattgg gattacaggt gtgagccatt gtgcttgatc aagatgctgt tatgggctga

541 gttgtgttcc tcaaaaattc tcttgaagtc ctaatctcaa gtacttcagg acgtgacctt

601 attttgaagg acccccttat agggtcttta cagaggtaat taagttaaaa tgaggccatt

661 aggatggggc ctaatgcaat atgactggta tccttgaaaa aaggggaaac ttggagactg

721 acttgcatac aaagagaaca gtgtgtgaac gtgaaaatgg ccaaggaggg aggcctggaa EPI-109 1073

781 tagagccttc cttcacatcc ctgagaagga atcaatcaat cctgctcagg ttaaccttga

841 tcttggactt ctagcctcca gcatcttgag agatttctgt tgtttaagtc atgcaatatg

901 tagtactttg ttacagcagc cctagcaaac tgatacactc accaaatcga ttttgtgact

961 cactattggg ttgtaaccag cagtacatag acataaagtt attttttcct tacgctttat

1021 cttgtgcaat cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgacgg

1081 agtcttgttc tgtcaccagg ctggagtgca gtggcttgat ctcggctcac tataatcaca

1141 gccttccaga ttcaagtgat ttccctgcct cagcctcctg agtagctggg actacaggcg

1201 cgcaccacca cgcccgacta attttttgta tttttagtag agacggggtt tcaccatgtt

1261 ggccaggatg gtctcaatct cctgaccttg tgatctgcct gcctcagcct cccaaagtgc

1321 tgggattaca ggcgtgagcc tctcttgtgc aatctttacc accactcaat gggatgtcaa

1381 ggtccagggg agggtgatac agtcaccctc acagtcatgc aggtgcagat gtcattaatg

1441 aaggtctgac agaccctgca attgtacaat ctgaagatga gtatctcctt aaatttcata

1501 ctctaggcac tttaccctag cctagactct gttgaagtag gtataactat tattctcatt

1561 tgagggattg acacctgatt gtgaacctcc taaatggagt catacccaag ccagatttgc

1621 ctctaaattc tgttttttcc ccttacatca cagtgttccc attggtatag tcagttacag

1681 agggagtaat atatactatt tttctaccag tacttgctcc tcgccttcct accccctaaa

1741 aggagccaaa gtcagagatc acatttactc ttttccctcc tcctctccaa gtctttgggg

1801 acttgtagct ctgacaccct tagatggtga aacctggctt cacctactgt ctgtggatgt

1861 ctgcaggcag agtgggcact caggagcaca tacaaagcac gtgtgccgtg aacacgtatg

1921 tgcacacacc ttgatcctag catggcttgt tggacaagcc aatggacaga gtccctgcct

1981 gccacctcca cccctgctct cccttctctt ccattcactg tcctgcagac acagcaaaca

2041 catacgcaca tacaccctca atatcctttt ggcagtaaca tgacccccaa atctggggac

2101 ttctatgtag gatggagacc cttctccttt cctcatacct ggtttattat gaaccataaa

2161 aatagtgcct gacagttact gtgtgtcagg cattgttcta agccttcaga tgttttactg

2221 cattttattc tcacattatg ggttaagact tatttgctcc attttacaga tgacgagaat

2281 gaatcacaga gtaaattgct cagggttgtg tggttagcag cattagcagg atttgaaccc

2341 aagcagcctg tatccacagt ccagtctttt aactgctata ttttgctgtg ttcaaaccct

2401 ctgctgcctg gctgggtcca cacacgtgca ctcatgcaca gacctgcggg gtagcaaggg

2461 atggaggagg aggagctggt tctggaaatc aattcaggca ccagggggca gcataggcct

2521 agctttggcc cctcagccca gcccctgcta tgggagggag gaggggagta gaaacttcct

2581 cccaccgccc ctcagacacc acctcttcca cacaccgggg ctctcaggtg tccgggagta

2641 aaggcctctc tggatccctt ggtctcctcc agctcctccc ccagcaaaaa ctgcagaacc

2701 ctccactagt tatgttgatg actcagaagt tgagcaagac tgtgtgtgtg tgtgtgtgtg

2761 tgtgtgtgtg tgtgtgtgtg tgtgtgtggt gttgtgattg caatgggctc tgtttgtgag

2821 cctgcctgca cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtagtcttg tggtcaggga

2881 agttgtgcat gtgtgtgttt gtttcttggc gtgtctcagt gtttacccca gaaacatata

2941 ggaacttggc agataggaac acagcagatt cgtattcaaa cttgcccctt gtgaatctgc

3001 aggcagcagc tccggcttgt gctggttccc accacagtct caggaggggt gccctgtgag

3061 gagagagcaa agaccagctt cagtccaagg gactcctaga gtcttccaga attctgagct

3121 gagggttccc ctcccccact ccctcccgtc agtggtcacg agaccgacct ctaaggcgtt

3181 ccctgccgga agggaggggg acctaggagt tggctggcat cgagctccct ggcggctttt

3241 tagggtcctc cactggaggg agcgcagagt ccagagggat ttacttttcc tgaggccctg

3301 gggagcccag tcccttgtgg gtccaaaccc cagcccttgg cagagtttga gtttgggagc

3361 caggcagtta ggggtggcaa atctctgttt gatattgggt gactttctgg agaaaagctg

3421 atgcttttga gggggacaga gtaagtgggg gtcagcctcc ccccaagcct ggctccaagg

3481 cctggacccc agtcctgatc ccccacgtgt tcccccactc ggcacaggag gcacacatat

3541 tcaccccact ttcttcctct tcctcctcca gcccactttc tcttctctgt gtcgtcagag

3601 ctccagggag ggacctgggt agaaggagaa gccggaaaca gcgggctggg gcagccactg

3661 cttacactga agagggagga cgggagagga gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt

3721 atgtatgtgt gtgctttatc ttatttttct ttttggtggt ggtgttggaa ggggggaggt

3781 gctagcaggg ccagccttga actcgctgga cagagctaca gacctatggg gcctggaagt

3841 gcccgctgag aaagggagaa gacagcagag gggttgccga ggtgaggggt tgcctccgag

3901 gtgggtgcgg gggcctctat gagtgcatgg gggtggattc gtggggggag ctctcgggat

3961 cctcccctgg ctgggtggat ggtccccaan gagatggttt cagctantgt tggtggctgg

4021 tggcactggg ttttancagt ttcgaactcc tggaggaact gggagggtcc aggcctcant

4081 actcccctcc cccatgggtc acgttttcac agcctcaccc ctgcaccccc aagggcccat

4141 ggaaagtcag ggaaaggagg tgaaggagtg cccctctgcc ctgagtcggg ggaagtggcc

4201 gcccctccct ggaaggttga tcgcagaggg cagtggatcc ttgttaaacc cctatcctgc

4261 cctccactaa aggttcctgt tcaagggtgt ggctggggcg tgagcaagcc ccagatgtag

4321 acctcatggt ggcccagacg agggggaatt tccccctcaa aactgctcca cgcttggctc

4381 gtgtagacgc tgagatttcc cagcggcggc gccgaattaa ccctcctcgt gctgaactgg

4441 ctccacctcc ccgccttgcc cccaccgcca cattcacgca ttgggcaact cagagaagat

4501 gttttaactt tcgatcctgt ggtccacaat gagaggactc gggcagatag gggttgagat

4561 aagcgagttt aggccaccaa gcgggcggac gaggatccca gaccttgcgc ttcccttctg

4621 agtttgggag gtaacactgg ccccgcccct cacgccgtgg ctcctccctc ccttcccctt

4681 caaggggctg aagacaaaag gtgcccctgt cctggtcaag ccaatcgacc cagccttgtt

4741 atgggttggg gtggggaaaa atgagtcctc ctgatggctg gggaagaaga ggggttggat

4801 atttctagcc agggccatgc caggaggctg gtcactctgc aaggggatgc agaggaaagc EPI-109 1074

4861 ggagcccact cactccagag gacctttctc ttcttgggct agagaaaggc ctattggagg 4921 aacctgagca ggaggggtaa ggattctgcc ttgaggagaa aagagctggg gtaagtgggc 4981 actggaggaa agaggggcat gaaggtcttg gagcagaaac gtccagagaa gggacctctc 5041 cattttccat ccctctgaga ggcctgggag aggtgagagg ctgaacgtgc aacaggagga 5101 cttggggtta ctgggtttgg ggagacctgg ggagttgtca tcccatcctc tccctcatct 5161 ctgggagagg gatattatga gaaacgtgaa ctgagaggcc cctgggaaac cactggttac 5221 ccagtcctcc ctgaacctgg aaatggggat gcaaccccct cttctacttc cctgtcccct 5281 cctctccttt ctacctgttt tcgtctctca tctttgcctt ctagccctcc agcttcctct 5341 ctcttctagg ctctttcctc ctagcttact aaacccgcct tttttccagt ctcttccatc 5401 ctcttcctta gttctctcta ctttcctttt ccacctctcc tccttcaagt ctcctcccac 5461 cttcccccac ttcttaggat gatcagattt gcccctggaa gggatcctaa caacacagtg 5521 cgatggttaa tccccactca gattcaaagc ctgctttcca aactcactta ctgagtggcc 5581 ttgggcagag tagagaaact ccttaagcct cagtttcttc atctataaaa tgggatatta 5641 tatattttaa aaagtgtcgt gaggcctgaa ggagataata cactgagtgt aatgcctcat 5701 acacagtaag tgcttaacaa atagtagctg ttattactct cccatcctct tcatcatcta 5761 gccttgtggt tttcattttt attttatttc atttatttat ttatttattt tgagcagagt 5821 ctctctctgt cgcccaggct ggagtgcagt ggctcgatct ctgctcactg caagctccgc 5881 cccccaggtt cacgccattc tgtcacctca gcctccccag tagctgggag tacaggcgct 5941 cgccaccacg ccctgctaat tttgtttttg tatttttagt agagatgggg tttcactgtg 6001 ttagccagga tggtcttgat ctcctgacct cgtgatctgc ccgcctcggc ctcccaaagc 6061 gctgggatta caggcatgag ccactgcgcc tggccgagcc ttgtggtttt caaattatct 6121 catggagtcc tagaattttg agaggtttgt ctagggatgc ctttggcgtc aggaggtggg 6181 gagagggaag tagaagcagt cgagtttcag gctttccatg cttgctttca acagggcatc 6241 ttcggtttcg taccttttat gtaattgaga ttccacagat taaaagctga cattgcctac 6301 cgctttaaaa agtttggaaa gttttccact catctaacac tcatatttta tagatgagaa 6361 gatcgaagcc cacaaaggga aggctctttg cccacagaac cagagccagg tctagagctg 6421 caactaaatc ctctgccact ctaagagagc tctcgctcta ctgccctgtc tccctttgcc 6481 tccccatccc tctggctaca gctcagctct tcccacccct gtgtctatca ctgaaggagt 6541 tacccccatc tcaggcattg actcaggatg cccctggttt aaggtggtct ggccatgagt 6601 ggtggtgggg acggtcccta ggagggctat ctatgggagg tcccctggct gccccaggag 6661 ataggccaag tttctttggg cacccctcag agtggcctta tttttttcct ccaggcaacc 6721 tccaagtccc agatcatgtc tctgtggggt ctggtctcca agatgccccc agaaaaagtg 6781 cagcggctct atgtcgactt tccccaacac ctgcggcatc ttctgggtga ctggctggag 6841 agccagccct ggtgagtcct ggctgctccc tgctggtccc ccaagtcttc cctaactcat 6901 cttccttctc cttagatttt tctcccctca cccatggatt cagaacttga gacctgttat 6961 tccatgtgta gtgacctaga tttagcaggg agtctgtgcc ccatcaagac caggctatga 7021 atgttgacag atggagaccc ccatctctta ggaggctgag ccgaagagga ggggggtttg 7081 ggctgggaca aaggcacttc tcataacagc tagaagactg ggaaacaagg cgcatgggtg 7141 aaagctacag agggcctaga tggagaataa ggagcgagaa aggaatgctg acttttggct 7201 gtggggtaaa ggtcaggaaa ctgaagaagc ctggcctgaa gtacctctcc tgatcttcct 7261 gcaagggagt tcctggtcgg ctccgacgcc ttctgctgca acttggctag tgccctactt 7321 tcagacactg tccagcacct tcaggcctcg gtgggagagc agggggaggg gagcaccatc 7381 ttgcaacaca tcagcaccct tgaggtgggg caggagggga ggggacaagg ctgggtgggg 7441 ctgaggttga actgggttga gcattgggcc ctggaagaaa attggttgga tgctggaagc 7501 aaattggtgt tcctgtggtt aactgctagc tagcaggcaa attagatttt aaaagcatgc 7561 aaatgcacaa aaacttctgg agtctacagt tgtgcttcct tatagtatat gtgtgaatgc 7621 aggcctgggg attggaggga ttgaaggaca tgggtaagag caaagctcac tgtttaccac 7681 cctcatttct gtagagcata tatcagaggg accccctgaa gctggtggcc actttcagac 7741 aaatacttca aggagagaaa aaagctgtta tggaacaggt attgtgatat tccacctccc 7801 accccaactc aatcccctga gactttggcc tgagccatga caaactagaa agaatttgat 7861 cctcagaaaa ggctcagtgt tctaggccca ggaatgacca aaggaggttc ctagggtcag 7921 agtgaacccc aagtcaagct cagggaatct ttctatgagg gactgaaggt aagaggccgg 7981 ggagaacaga gcaagggata aggagctgat tctgctagga gcaaggtctt atctccacga 8041 tattccaaaa ggtcaggaag aactgccaaa ggggagaggg gaacaagaaa acgctatatg 8101 cagagcagag agtggaggcc aggtatagag ggatgagcag agtgtttgag ttcttggcat 8161 ctgtccttcc tgtgtagttc cgccacttgc caatgccttt ccactggaag caggaagaac 8221 tcaagtttaa gacaggcttg cggaggctgc agcaccgagt aggggagatc caccttctcc 8281 gacaagccct gcagaagggg gctgaggctg gccaaggtgg gggccagggt ggttctgggg 8341 agtgtgtaag agtggttgcc tcttggatct caaccttatc tgaacctcta atctgtctgc 8401 acccttgatt tctgccccca accctcagtg tctctgcaca gcttgataga aactcctgct 8461 aatgggactg ggccaagtga ggtgagtaat gggctgacag gtggagacct tggtcaaagt 8521 gcagctggag ggatggaagc tagacctcag aaagacacag gctgaagtag ggcaagggaa 8581 tgccagagga gtgagaaaaa gaccgtatcc caggagctgg gtgtggaggc agcgtgaggc 8641 cctggctcag gcccctctct gcccataggc cctggccatg ctactgcagg agaccactgg 8701 agagctagag gcagccaaag ccctagtgct gaagaggatc cagatttgga aacggcagca 8761 gcagctggca gggaatggcg caccgtttga ggagagcctg gccccactcc aggagaggtt 8821 gggctagggc tgatggggaa gagggggcaa gctgggggtg ggcagctgac cctgctgaag 8881 gccctacagg tgagagaaag aagccaggcg ggagggcctt ggcagtggac caagatgcat EPI-109 1075

8 41 aaaagccagt tccagcgggg ctgtgcacac tgtcgttcag gtcgcatcct gtacaagtgg

9001 gcctagtgga ggggcacaag cggggactca tccaacccag gcttctctcc tcaagcccca

9061 tgcctagagg aataggaggg cttttccatt tggtttattg ggtgggaaca cttcccaatt

9121 tgccacaaag cactgtaagt ggtggcagtt gttcttgggt gcaagaaccg tcggggagag

9181 gcagctgggt ttccacaggg ggtgtaggca actgataatg aacctcccac ccacacccta

9241 ggccaacaga tcacagaacc ccttcagccc aggtgccttg cagccacacc cactacccac

9301 cccacttctc cacacatgat agcctttctc cctgggtata ggggaagggg gtctgggccg

9361 gagcaagcag ccttaatcct gtgccccctg accactgtcc tggccccagg tgtgaaagcc

9421 tggtggacat ttattcccag ctacagcagg aggtaggggc ggctggtggg gagcttgagc

9481 ccaagacccg ggcatcgctg actggccggc tggatgaagt cctgagaacc ctcgtcacca

9541 ggtattcccc gggagctccc agtctggcct agaacagacc tcgggaagaa aagaaggggg

9601 ctagagctgt ggggagggca ccagcaggga cctagccccc aactcccctt gtgtcctcct

9661 cactcccagt tgcttcctgg tggagaagca gcccccccag gtactgaaga ctcagaccaa

9721 gttccaggct ggagttcgat tcctgttggg cttgaggttc ctgggggccc cagccaagcc

9781 tccgctggtc agggccgaca tggtgacaga gaagcaggcg cgggagctga gtgtgcctca

9841 gggtcctggg gctggagcgt aagctgggat tggacctggg gttggagaag ggctgttagg

9901 gtgatggagg cagcctggag ggctggcact gaaaagagea agggatgggg agggagggcc

9961 atgggatgtg gagaccctga atggtcaagg cagaggaaag ggagggaccc atttagggct

10021 ggaatggggt gggggcatca tgatttggcc aagatgggga ctcctccctt aagaacccaa

10081 acagagacat ggagatttag ggctggtgac agtgggtagt ctacactcac ccatgcactc

10141 gccacacctg acgacagtga gatgagctcg ttcacactct gacctcccct gggcagagaa

10201 agcactggag aaatcatcaa caacactgtg cccttggaga acagcattcc tgggaactgc

10261 tgctctgccc tgttcaagaa cctggtgagg ggctttgggg tgcagtgagg ggggcaccac

10321 taggagactg tgggactctc cttggagagg atgtcaggaa gcccaggagg agcggtctct

10381 gtcctcatga cctcgccctt gctctccctc accccaccca cagcttctca agaagatcaa

10441 gcggtgtgag cggaagggca ctgagtctgt cacagaggag aagtgcgctg tgctcttctc

10501 tgccagcttc acacttggcc ccggcaaact ccccatccag ctccaggtga accgtggccc

10561 agccctgccc caatctggga ccccgagtcc tcctccaatg ccacgcacaa gggccctgga

10621 ccctcacctc ttgtgactgc cccatacccc atgtgtctgg gattcatgca cactggggcc

10681 cgggtgagtg ggggtgagca agagcatgga gtgcacaggg cagggaatgg tagtggatag

10741 cagcaaacac ttcggaagca cttcctatag accaggggca ctctattaaa tgatacatac

10801 tgcacatgcg tgccagcaca cacacgtctg gttttcacaa taacattatg aggtaggcag

10861 tattatcagc ctcattttat agcatgagga cattgagaca gagagtttaa gtagtttgtc

10921 ccagtcaccc agctaagtgt tggagctggt atctgaaacc tggaagtctg gttccatagc

10981 gattatagta accacttctc tacggtgagg ccctgattga gcttcaaaac gcatttaata

11041 acatgg

(2) INFORMATION FOR SEQ ID NO:2808: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2808

1 ggaaagaaag aaagaaaaga aaccctgtcc tcaccctact tcaggccctg tctctgcccc 61 tggtggtcat cgtccatggc aaccaagaca acaatgccaa agccactatc ctgtgggaca 121 atgccttctc tgagatggtg aggaaagtcc ttggtagttg gagggaacag ggtgcagggt 181 gggttctaac atgggcagtg gtgcaggcct gctgatgggg tggtgggcat gtcggatggg 241 tgtgacctta acacttcttc atgggcctgc tttcgtgctt ctgacctctt ttcaccccag 301 tcttaacaac tatcaggcca cagcactgta acctagaaaa aacagcatgt ttgtgagcga 361 tatcaggggc tgtggagggg taggccacag gcatgtggga cggatgaagg ccggcccgag 421 gaataacaag acggtagcct gcagtgctct cttcttcccc cttctcccca ggaccgcgtg 481 ccctttgtgg tggctgagcg ggtgccctgg gagaagatgt gtgaaactct gaacctgaag 541 ttcatggctg aggtggggac caaccggggg ctgctcccag agcacttcct cttcctggcc 601 cagaagatct tcaatgacaa cagcctcagt atggaggcct tccagcaccg ttctgtgtcc 661 tggtcgcagt tcaacaaggt tcagttctcc

(2) INFORMATION FOR SEQ ID NO: 2809: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2809

1 gcggccgcga gctctaatac gactcactat agggcgtcga ctcgatcata ccactgcact

61 caagcctggg tgacagagca agactctgtc tcaaaaaaaa aaaaaaaaaa aggccaggca

121 tggtggttca tgcctgtaat cccagcactt tgggaggccg agacggatag atcacctgag

181 gtcaggagtt cgagaccagc ctggccaaca tggcaaaacc ccgtctctac taaaaacaaa

241 aaaatagcca ggatggtcgt ttgcgtctgt aatcccagct actcggctga ggcaggaggt EPI-109 1076

301 gaacccagga ggtaaaggct gcaggggaag atgaaaccat tgcactccag cctgggcaag

361 actctgtatc aaaaaaaaaa aaaaaaaggc taggtgtggt ggctcacacc tgtaatccca

421 gcactttggg aggctgaggc gggcggatca caaggtcaag aaatcgagac catcctgacc

481 aacatggtga aaccccgtct ctactaaaaa tacaaaaatt acctgggcat ggtggcgcat

541 gcctgtattc ccaactactc gggaggctga ggcatgaaaa tcacttgaac ctgggaggca

601 gaggttgcag gcgagccaag attgtgccac tgcactccag cctgccaaca aaaatgagat

661 tctgtc

(2) INFORMATION FOR SEQ ID NO:2810: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2810

1 ggttaccttc cctttgggcg tcaacttctg ccacacctcc ttagggagag ggtgtagcat

61 agtagttaag aggggtccag ggccagaatg cctgggttta aatcctagct ctgcctctta

121 ccagctatgt agacctgggc aagtcattcg acgtttttgg acttccattt cttcatctgt

181 aagatggaat tattataatc cctacttcca tagcctggta aagagcaaat aaatatatgg

241 aaaggcttga aatagtggct ggcacgtgta agcattagga ttggtcgttg tcattgatgg

301 agtctcaggt tcggtctgat cctcagcccc tgtgattctg tcgtgagggc actcacagct

361 cactgcctgc cctaaacagg ctccagctct ggccctccct cggctcacac ctttccccct

421 ctccccctag gagatcctgc tgggccgtgg cttcaccttt tggcagtggt ttgatggtgt

481 cctggacctc accaaacgct gtctccggag ctactggtct gaccggtgag tccccaccct

541 gggtagtttg agcagccata caccagtcac ctccatactc actgcccatg ccccatcctc

601 tccttcatcc cggccaggct gatcattggc ttcatcagca aacagtacgt tactagcctt

661 cttctcaatg agcccgacgg aacctttctc ctccgcttca gcgactcaga gattgggggc

721 atcaccattg cccatgtcat ccggggccag gatggtgagg ccaccccagc cagtcctctg

781 tctctgtgcc tgtgccctct ggggtttctt ctgggaatga aatgtcctga ccttcctgat

841 gccgatcctg atcttcagga agttcttcca gcttctcttc ttccttctgt ggtctaaatg gθl ttcaccttct cactgtgagc tctgtgggaa cggagactag tgggtctctc tccctcagga

961 gccccaccct aggtcctctc tcccttgcct tggtggagtg agaacaggtc ttatggtagg

1021 ggttggggaa ggggaagaaa tccggacaga gggatctcag ggtctccttc ctaccatagg

1081 ctctccacag atagagaaca tccagccatt ctctgccaaa gacctgtcca ttcgctcact

1141 gggggaccga atccgggatc ttgctcagct caaaaatctc tatcccaaga agcccaagga

1201 tgaggctttc cggagccact acaagcgtga gctggaactg gcagctctga ttccttcctg

1261 tcacccactt cctgccatgc tccccgctgc catcctctcc ccagcccgtg agttatcctg

1321 aggtcactcc gaatttccat agctgtgctt ttcttacttc ccggatgatc catgcccacc

1381 ttttccacct cccttcctcc ctaacccgag agcaatccat ggcagtcttt tccatctcac

1441 aacagctgaa cagctgaaca gatgggtaag gatggcaggg gttatgtccc agctaccatc

1501 aagatgaccg tggaaaggtg agtgtggtgg tatggacagt gggtaggtca ggggcttagt

1561 gcttatctgc aggaaggagg ggtggcatca acccttggtc agtcacatgt acctccttcc

1621 ctcctccagg gaccaaccac ttcctacccc agagctccag atgcctacca tggtgccttc

1681 ttatgacctt ggaatggccc ctgattcctc catgagcatg cagcttggcc cagatatggt

1741 gtaaggagct ggaaagacag gaatgggagt ggtctgtgca gatgggctaa tcttagcatg

1801 ggcagctggg agagctggca ctgggggctg aacagggaat cttcctttcc atgagaggga

1861 cacctgttca aaagcagggt gtggtggtgt ccaggagaag ggctggcatc agggggtctg

1921 ttttctttcc ccaggcccca ggtgtaccca ccacactctc actccatccc cccgtatcaa

1981 ggcctctccc cagaagaatc agtcaacgtg ttgtcagcct tccaggagta agtgaaaaac

2041 ctcatgggga taccatccca ctctaagggg gtgggcattt gaattgttag aagaggctct

2101 tctgtgagaa aggagcagca aatgctaaca gcctgtcttc ttctcttctg tccactctaa

2161 tgagggggta gtagttaaga tctggactgc ctaggtttga attctagctc caccacttac

2221 tggtttgggg caaattactt agcctttggt gccttatctg cacaatgggg gataataatg

2281 ctaataataa taacctacct cactgcatta ttgtggagat taaatgagtt cataacactt

2341 aaaaagctcg agcatagtgc atggctcata gcaaaagctg tgtaagtcca gtcgtggatc

2401 acttaatgaa ggagcatttt ctgtctttgg cagtttcata attatgcgga ataccattga

2461 gtataattac acaaacctag atggtataga ctactataca ctgaggctat attgtgtagc

2521 ctattgatcc tagctttaaa cccgagcagc atgatactgt tctgaatagt ataaggaaat

2581 agtaacataa tggtaaatat ttgtgtgata ggaattttca gcttgattat aatttttttt

2641 ttttgagaca gggtctcact cactggagtg cagtggtgcg atcttagctc ccctgcaacc

2701 tccgcctctt gggctcgagc aatcctcctg ctgtagtgca ccacgacact cggctaattc

2761 ttttttaaga tttttctgca gacaaggtct cacttactgc ccaagctggt ctcaaactcc

2821 tgggcttaag tgatcctccc acctcggcct cccaaagcgt taggattaca ggcgtgagtc

2881 actctgcctg gccttgatta taatcttatg ggaccactgt ggtctgtagt tgacagaaat

2941 gtcgttaatg tggtgcatga ctgttattat tattttctgt cctgcccctg agagccactg

3001 tcacttctct gctgtattgg tttttgttta ctcatctgtt ttggccttga aatggcctag

3061 acatttttct tcccgaagta tgacactcgg gtgcttatta acttagtcaa gacacaacat

3121 ctcccttccc agaaagtgag gcgggagtga ggacttgggg acttaagaac taccaaagtt

3181 cagagtccaa aggaaacatt agaaattggg taatccaccc ccataacacg cacattttac EPI-109 1077

3241 agatgagaag actgagctca gagcatagaa atagcttgcc caggccatga ctaagtcagg

3301 ataaggagct ggagcttgtt tcctcactca gtggtcctga ctttgcacca ctctgcattt

3361 gcctagcctg ccttcctcta actgtgctct ccctacttcc aggcctcacc tgcagatgcc

3421 ccccagcctg ggccagatga acctgccctt tgaccagcct cacccccagg tgaatgacaa

3481 aagcccctcc tgacccatgt gcctcttctt tcctgggcct tgcccgctct ccttatttcc

3541 attgctggtt cctggcaggg cctgctgccg tgccagcctc aggagcatgc tgtgtccagc

3601 cctgaccccc tgctctgctc agatgtgacc atggtggaag acagctgcct gagccagcca

3661 gtgacagcgt ttcctcaggg cacttggtga gtggcagctt gggagtggag gctgggtggc

3721 atctagggga gtgggcgcca tgcctactcc actgcttctc ccatctcctt gcaggattgg

3781 tgaagacata ttccctcctc tgctgcctcc cactgaacag gacctcacta agcttctcct

3841 ggaggggcaa ggggagtcgg ggggagggtc cttgggggca cagcccctcc tgcagccctc

3 θl ccactatggg caatctggga tctcaatgtc ccacatggac ctaagggcca accccagttg

3 61 gtgatcccag ctggagggag aacccaaaga gacagctctt ctactacccc cacagacctg

4021 ctctggacac ttgctcatgc cctgccaagc agcagatggg gagggtgccc tcctatcccc

4081 acctactcct gggtcaggag gaaaagacta acaggagaat gcacagtggg tggagccaat

4141 ccactccttc ctttctatca ttcccctgcc cacctccttc cagcactgac tggaagggaa

4201 gttcaggctc tgagacacgc cccaacatgc ctgcacctgc agcgcgcaca cgcacgcaca

4261 cacacataca gagctctctg agggtgatgg ggctgagcag gaggggggct gggtaagagc

4321 acaggttagg gcatggaagg cttctccgcc cattctgacc cagggcctag gacggatagg

4381 caggaacata cagacacatt tacactagag gccagggata gaggatattg ggtctcagcc

4441 ctaggggaat gggaagcagc tgaagggacc ctgggtggga gcataggagg agtctggaca

4501 tgtggttact agtacaggtt ttgccctgat taaaaaatct cccaaagccc caaattcctg

4561 ttagccaggt ggaggcttct gatacgtgta tgagactatg caaaagtaca agggctgaga

4621 ttcttcgtgt atagctgtgt gaacgtgtat gtacctagga tatgttaaat atatagctgg

4681 caccttagtt gcatgaccac atagaacatg tgtctatctg cttttgccta cgtgacaaca

4741 caaatttggg agggtgagac actgcacaga agacagcagc aagtgtgctg gcctctctga

4801 catatgctaa cccccaaata ctctgaattt ggagtctgac tgtgcccaag tgggtccaag

4861 tggctgtgac atctacgtat ggctccacac ctccaatgct gcctgggagc cagggtgaga

4921 gtctgggtcc aggcctggcc atgtggccct ccagtgtatg agagggccct gcctgctgca

4981 tcttttctgt tgccccatcc accgccagct tcccttcact cccctatccc attctccctc

5041 tcaaggcagg ggtcatagat cctaagccat aaaataaatt ttattccaaa ataacaaaat

5101 aaataatcta ctgtacacaa tctgaaaaga aagacgctct aactgctcag ataggtgctg

5161 cggtccagcc cccagctgga ggagaccctg agtccaaccc aggcctcccg agggggccag

5221 tgaagggatc ccacacccac cgcccctatg tagggcaggg aagaaattgc aaaggacttg

5281 ggggatagat gggaatggga gggcaaactg cagcacttgt taaattaatt aaagaaacaa

5341 accagaagca caaaaacggg gaaggagaag ggagaaggag caggtccagt gttccaggcc

5401 ccaattctgg gggcaaatgt gcca

(2) INFORMATION FOR SEQ ID NO: 2811: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2811

1 gcagcaccta tctgagcagt tagagcgtct ttcttttcag attgtgtaca gtagattatt

61 tattttgtta ttttggaata aaatttattt tatggcttag gatctatgac ccctgccttg

121 agagggagaa tgggataggg gagtgaaggg aagctggcgg tggatggggc aacagaaaag

181 atgcagcagg cagggccctc tcatacactg gagggccaca tggccaggcc tggacccaga

241 ctctcaccct ggctcccagg cagcattgga ggtgtggagc catacgtaga tgtcacagcc

301 acttggaccc acttgggcac agtcagactc caaattcaga gtatttgggg gttagcatat

361 gtcagagagg ccagcacact tgctgctgtc ttctgtgcag tgtctcaccc tcccaaattt

421 gtgttgtcac gtaggcaaaa gcagatagac acatgttcta tgtggtcatg caactaaggt

481 gccagctata catttaacat atcctaggta catacacgtt cacacagcta tacacgaaga

541 atctcagccc ttgtactttt gcatagtctc atacacgtat cagaagcctc cacctggcta

601 acaggaattt ggggctttgg gagatttttt aatcagggca aaacctgtac tagtaaccac

661 atgtccagac ccctcctatg ctcccaccca gggtcccttg agctgcttcc cattccccta

721 gggctgagac ccaatatcct ctatccctgg cctctagtgt aaatgtgtct gtatgttcct

781 gcctatccgt cctaggccct gggtcagaat gggcggagaa gccttccatg ccctaacctg

841 tgctcttacc cagcccccct cctgctcagc cccatcaccc tcagagagct ctgtatgtgt

901 gtgtgcgtgc gtgtgcgcgc tgcaggtgca ggcatgttgg ggtgtgtctc agagcctgaa

961 cttcccttcc agtcagtact ggaaggaggt gggcagggga atgatagaaa ggaaggagtg

1021 gattggctcc acccactgtg cattctcctg ttagtctttt cctcctgacc caggagtagg

1081 tggggatagg agggcaccct ccccatctgc tgcttggcag ggcatgagca agtgtccaga

1141 gcaggtctgt gggggtagta gaagagctgt ctctttgggt tctccctcca gctgggatca

1201 ccaactgggg ttggccctta ggtccatgtg ggacattgag atcccagatt gcccatagtg

1261 ggagggctgc aggaggggct gtgcccccaa ggaccctccc cccgactccc cttgcccctc

1321 caggagaagc ttagtgaggt cctgttcagt gggaggcagc agaggaggga atatgtcttc

1381 accaatcctg caaggagatg ggagaagcag tggagtaggc atggcgccca ctcccctaga EPI-109 1078

1441 tgccacccag cctccactcc caagctgcca ctcac

(2) INFORMATION FOR SEQ ID NO:2812: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2812

1 tttattttta atttaatcac ttaattttta atttttaaga tggagtctca ctctgttgcc

61 caggctgaag tgcaagggtg taatctcagc tcactgcagc ctctgcctcc cggattccag

121 tgattttcct gcttcagctt cccaggtagc tgggattgca ggcacatgcc actgtgccca

181 gataattttt tgtatttttt agtagagacg gggcttcacc atgttggcca ggctggtctt

241 gaactcctaa cctcagatga tccgcacacc tcggcctccc aaagtgctag gattacaggc

301 atgagcctct gcgcctggcc tttacttcag tttcaaagag tgaaggtcaa gacactgttt

361 ttttttatgt tttgttttta attttgtttt aaattttttt tgtagagatg ggatcttgct

421 atgttgccca ggctggtctc gaactcctgg cctccagcaa tcctcctgcc tcagcctccc

481 agagtattgg gattacaggt gtgagccatt gtgcttgatc aagatgctgt tatgggctga

541 gttgtgttcc tcaaaaattc tcttgaagtc ctaatctcaa gtacttcagg acgtgacctt

601 attttgaagg acccccttat agggtcttta cagaggtaat taagttaaaa tgaggccatt

661 aggatggggc ctaatgcaat atgactggta tccttgaaaa aaggggaaac ttggagactg

721 acttgcatac aaagagaaca gtgtgtgaac gtgaaaatgg ccaaggaggg aggcctggaa

781 tagagccttc cttcacatcc ctgagaagga atcaatcaat cctgctcagg ttaaccttga

841 tcttggactt ctagcctcca gcatcttgag agatttctgt tgtttaagtc atgcaatatg θl tagtactttg ttacagcagc cctagcaaac tgatacactc accaaatcga ttttgtgact

961 cactattggg ttgtaaccag cagtacatag acataaagtt attttttcct tacgctttat

1021 cttgtgcaat cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgacgg

1081 agtcttgttc tgtcaccagg ctggagtgca gtggcttgat ctcggctcac tataatcaca

1141 gccttccaga ttcaagtgat ttccctgcct cagcctcctg agtagctggg actacaggcg

1201 cgcaccacca cgcccgacta attttttgta tttttagtag agacggggtt tcaccatgtt

1261 ggccaggatg gtctcaatct cctgaccttg tgatctgcct gcctcagcct cccaaagtgc

1321 tgggattaca ggcgtgagcc tctcttgtgc aatctttacc accactcaat gggatgtcaa

1381 ggtccagggg agggtgatac agtcaccctc acagtcatgc aggtgcagat gtcattaatg

1441 aaggtctgac agaccctgca attgtacaat ctgaagatga gtatctcctt aaatttcata

1501 ctctaggcac tttaccctag cctagactct gttgaagtag gtataactat tattctcatt

1561 tgagggattg acacctgatt gtgaacctcc taaatggagt catacccaag ccagatttgc

1621 ctctaaattc tgttttttcc ccttacatca cagtgttccc attggtatag tcagttacag

1681 agggagtaat atatactatt tttctaccag tacttgctcc tcgccttcct accccctaaa

1741 aggagccaaa gtcagagatc acatttactc ttttccctcc tcctctccaa gtctttgggg

1801 acttgtagct ctgacaccct tagatggtga aacctggctt cacctactgt ctgtggatgt

1861 ctgcaggcag agtgggcact caggagcaca tacaaagcac gtgtgccgtg aacacgtatg

1921 tgcacacacc ttgatcctag catggcttgt tggacaagcc aatggacaga gtccctgcct

1981 gccacctcca cccctgctct cccttctctt ccattcactg tcctgcagac acagcaaaca

2041 catacgcaca tacaccctca atatcctttt ggcagtaaca tgacccccaa atctggggac

2101 ttctatgtag gatggagacc cttctccttt cctcatacct ggtttattat gaaccataaa

2161 aatagtgcct gacagttact gtgtgtcagg cattgttcta agccttcaga tgttttactg

2221 cattttattc tcacattatg ggttaagact tatttgctcc attttacaga tgacgagaat

2281 gaatcacaga gtaaattgct cagggttgtg tggttagcag cattagcagg atttgaaccc

2341 aagcagcctg tatccacagt ccagtctttt aactgctata ttttgctgtg ttcaaaccct

2401 ctgctgcctg gctgggtcca cacacgtgca ctcatgcaca gacctgcggg gtagcaaggg

2461 atggaggagg aggagctggt tctggaaatc aattcaggca ccagggggca gcataggcct

2521 agctttggcc cctcagccca gcccctgcta tgggagggag gaggggagta gaaacttcct

2581 cccaccgccc ctcagacacc acctcttcca cacaccgggg ctctcaggtg tccgggagta

2641 aaggcctctc tggatccctt ggtctcctcc agctcctccc ccagcaaaaa ctgcagaacc

2701 ctccactagt tatgttgatg actcagaagt tgagcaagac tgtgtgtgtg tgtgtgtgtg

2761 tgtgtgtgtg tgtgtgtgtg tgtgtgtggt gttgtgattg caatgggctc tgtttgtgag

2821 cctgcctgca cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtagtcttg tggtcaggga

2881 agttgtgcat gtgtgtgttt gtttcttggc gtgtctcagt gtttacccca gaaacatata

2941 ggaacttggc agataggaac acagcagatt cgtattcaaa cttgcccctt gtgaatctgc

3001 aggcagcagc tccggcttgt gctggttccc accacagtct caggaggggt gccctgtgag

3061 gagagagcaa agaccagctt cagtccaagg gactcctaga gtcttccaga attctgagct

3121 gagggttccc ctcccccact ccctcccgtc agtggtcacg agaccgacct ctaaggcgtt

3181 ccctgccgga agggaggggg acctaggagt tggctggcat cgagctccct ggcggctttt

3241 tagggtcctc cactggaggg agcgcagagt ccagagggat ttacttttcc tgaggccctg

3301 gggagcccag tcccttgtgg gtccaaaccc cagcccttgg cagagtttga gtttgggagc

3361 caggcagtta ggggtggcaa atctctgttt gatattgggt gactttctgg agaaaagctg

3421 atgcttttga gggggacaga gtaagtgggg gtcagcctcc ccccaagcct ggctccaagg

3481 cctggacccc agtcctgatc ccccacgtgt tcccccactc ggcacaggag gcacacatat

3541 tcaccccact ttcttcctct tcctcctcca gcccactttc tcttctctgt gtcgtcagag EPI-109 1079

3601 ctccagggag ggacctgggt agaaggagaa gccggaaaca gcgggctggg gcagccactg

3661 cttacactga agagggagga cgggagagga gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt

3721 atgtatgtgt gtgctttatc ttatttttct ttttggtggt ggtgttggaa ggggggaggt

3781 gctagcaggg ccagccttga actcgctgga cagagctaca gacctatggg gcctggaagt

3841 gcccgctgag aaagggagaa gacagcagag gggttgccga ggtgaggggt tgcctccgag

3901 gtgggtgcgg gggcctctat gagtgcatgg gggtggattc gtggggggag ctctcgggat

3961 cctcccctgg ctgggtggat ggtccccaan gagatggttt cagctantgt tggtggctgg

4021 tggcactggg ttttancagt ttcgaactcc tggaggaact gggagggtcc aggcctcant

4081 actcccctcc cccatgggtc acgttttcac agcctcaccc ctgcaccccc aagggcccat

4141 ggaaagtcag ggaaaggag^'g tgaaggagtg cccctctgcc ctgagtcggg ggaagtggcc

4201 gcccctccct ggaaggttga tcgcagaggg cagtggatcc ttgttaaacc cctatcctgc

4261 cctccactaa aggttcctgt tcaagggtgt ggctggggcg tgagcaagcc ccagatgtag

4321 acctcatggt ggcccagacg agggggaatt tccccctcaa aactgctcca cgcttggctc

4381 gtgtagacgc tgagatttcc cagcggcggc gccgaattaa ccctcctcgt gctgaactgg

4441 ctccacctcc ccgccttgcc cccaccgcca cattcacgca ttgggcaact cagagaagat

4501 gttttaactt tcgatcctgt ggtccacaat gagaggactc gggcagatag gggttgagat

4561 aagcgagttt aggccaccaa gcgggcggac gaggatccca gaccttgcgc ttcccttctg

4621 agtttgggag gtaacactgg ccccgcccct cacgccgtgg ctcctccctc ccttcccctt

4681 caaggggctg aagacaaaag gtgcccctgt cctggtcaag ccaatcgacc cagccttgtt

4741 atgggttggg gtggggaaaa atgagtcctc ctgatggctg gggaagaaga ggggttggat

4801 atttctagcc agggccatgc caggaggctg gtcactctgc aaggggatgc agaggaaagc

4861 ggagcccact cactccagag gacctttctc ttcttgggct agagaaaggc ctattggagg

4921 aacctgagca ggaggggtaa ggattctgcc ttgaggagaa aagagctggg gtaagtgggc

4981 actggaggaa agaggggcat gaaggtcttg gagcagaaac gtccagagaa gggacctctc

5041 cattttccat ccctctgaga ggcctgggag aggtgagagg ctgaacgtgc aacaggagga

5101 cttggggtta ctgggtttgg ggagacctgg ggagttgtca tcccatcctc tccctcatct

5161 ctgggagagg gatattatga gaaacgtgaa ctgagaggcc cctgggaaac cactggttac

5221 ccagtcctcc ctgaacctgg aaatggggat gcaaccccct cttctacttc cctgtcccct

5281 cctctccttt ctacctgttt tcgtctctca tctttgcctt ctagccctcc agcttcctct

5341 ctcttctagg ctctttcctc ctagcttact aaacccgcct tttttccagt ctcttccatc

5401 ctcttcctta gttctctcta ctttcctttt ccacctctcc tccttcaagt ctcctcccac

5461 cttcccccac ttcttaggat gatcagattt gcccctggaa gggatcctaa caacacagtg

5521 cgatggttaa tccccactca gattcaaagc ctgctttcca aactcactta ctgagtggcc

5581 ttgggcagag tagagaaact ccttaagcct cagtttcttc atctataaaa tgggatatta

5641 tatattttaa aaagtgtcgt gaggcctgaa ggagataata cactgagtgt aatgcctcat

5701 acacagtaag tgcttaacaa atagtagctg ttattactct cccatcctct tcatcatcta

5761 gccttgtggt tttcattttt attttatttc atttatttat ttatttattt tgagcagagt

5821 ctctctctgt cgcccaggct ggagtgcagt ggctcgatct ctgctcactg caagctccgc

5881 cccccaggtt cacgccattc tgtcacctca gcctccccag tagctgggag tacaggcgct

5941 cgccaccacg ccctgctaat tttgtttttg tatttttagt agagatgggg tttcactgtg

6001 ttagccagga tggtcttgat ctcctgacct cgtgatctgc ccgcctcggc ctcccaaagc

6061 gctgggatta caggcatgag ccactgcgcc tggccgagcc ttgtggtttt caaattatct

6121 catggagtcc tagaattttg agaggtttgt ctagggatgc ctttggcgtc aggaggtggg

6181 gagagggaag tagaagcagt cgagtttcag gctttccatg cttgctttca acagggcatc

6241 ttcggtttcg taccttttat gtaattgaga ttccacagat taaaagctga cattgcctac

6301 cgctttaaaa agtttggaaa gttttccact catctaacac tcatatttta tagatgagaa

6361 gatcgaagcc cacaaaggga aggctctttg cccacagaac cagagccagg tctagagctg

6421 caactaaatc ctctgccact ctaagagagc tctcgctcta ctgccctgtc tccctttgcc

6481 tccccatccc tctggctaca gctcagctct tcccacccct gtgtctatca ctgaaggagt

6541 tacccccatc tcaggcattg actcaggatg cccctggttt aaggtggtct ggccatgagt

6601 ggtggtgggg acggtcccta ggagggctat ctatgggagg tcccctggct gccccaggag

6661 ataggccaag tttctttggg cacccctcag agtggcctta tttttttcct ccaggcaacc

6721 tccaagtccc agatcatgtc tctgtggggt ctggtctcca agatgccccc agaaaaagtg

6781 cagcggctct atgtcgactt tccccaacac ctgcggcatc ttctgggtga ctggctggag

6841 agccagccct ggtgagtcct ggctgctccc tgctggtccc ccaagtcttc cctaactcat

6901 cttccttctc cttagatttt tctcccctca cccatggatt cagaacttga gacctgttat

6961 tccatgtgta gtgacctaga tttagcaggg agtctgtgcc ccatcaagac caggctatga

7021 atgttgacag atggagaccc ccatctctta ggaggctgag ccgaagagga ggggggtttg

7081 ggctgggaca aaggcacttc tcataacagc tagaagactg ggaaacaagg cgcatgggtg

7141 aaagctacag agggcctaga tggagaataa ggagcgagaa aggaatgctg acttttggct

7201 gtggggtaaa ggtcaggaaa ctgaagaagc ctggcctgaa gtacctctcc tgatcttcct

7261 gcaagggagt tcctggtcgg ctccgacgcc ttctgctgca acttggctag tgccctactt

7321 tcagacactg tccagcacct tcaggcctcg gtgggagagc agggggaggg gagcaccatc

7381 ttgcaacaca tcagcaccct tgaggtgggg caggagggga ggggacaagg ctgggtgggg

7441 ctgaggttga actgggttga gcattgggcc ctggaagaaa attggttgga tgctggaagc

7501 aaattggtgt tcctgtggtt aactgctagc tagcaggcaa attagatttt aaaagcatgc

7561 aaatgcacaa aaacttctgg agtctacagt tgtgcttcct tatagtatat gtgtgaatgc

7621 aggcctgggg attggaggga ttgaaggaca tgggtaagag caaagctcac tgtttaccac EPI-109 1080

7681 cctcatttct gtagagcata tatcagaggg accccctgaa gctggtggcc actttcagac

7741 aaatacttca aggagagaaa aaagctgtta tggaacaggt attgtgatat tccacctccc

7801 accccaactc aatcccctga gactttggcc tgagccatga caaactagaa agaatttgat

7861 cctcagaaaa ggctcagtgt tctaggccca ggaatgacca aaggaggttc ctagggtcag

7921 agtgaacccc aagtcaagct cagggaatct ttctatgagg gactgaaggt aagaggccgg

7981 ggagaacaga gcaagggata aggagctgat tctgctagga gcaaggtctt atctccacga

8041 tattccaaaa ggtcaggaag aactgccaaa ggggagaggg gaacaagaaa acgctatatg

8101 cagagcagag agtggaggcc aggtatagag ggatgagcag agtgtttgag ttcttggcat

8161 ctgtccttcc tgtgtagttc cgccacttgc caatgccttt ccactggaag caggaagaac

8221 tcaagtttaa gacaggcttg cggaggctgc agcaccgagt aggggagatc caccttctcc

8281 gacaagccct gcagaagggg gctgaggctg gccaaggtgg gggccagggt ggttctgggg

8341 agtgtgtaag agtggttgcc tcttggatct caaccttatc tgaacctcta atctgtctgc

8401 acccttgatt tctgccccca accctcagtg tctctgcaca gcttgataga aactcctgct

8461 aatgggactg ggccaagtga ggtgagtaat gggctgacag gtggagacct tggtcaaagt

8521 gcagctggag ggatggaagc tagacctcag aaagacacag gctgaagtag ggcaagggaa

8581 tgccagagga gtgagaaaaa gaccgtatcc caggagctgg gtgtggaggc agcgtgaggc

8641 cctggctcag gcccctctct gcccataggc cctggccatg ctactgcagg agaccactgg

8701 agagctagag gcagccaaag ccctagtgct gaagaggatc cagatttgga aacggcagca

8761 gcagctggca gggaatggcg caccgtttga ggagagcctg gccccactcc aggagaggtt

8821 gggctagggc tgatggggaa gagggggcaa gctgggggtg ggcagctgac cctgctgaag

8881 gccctacagg tgagagaaag aagccaggcg ggagggcctt ggcagtggac caagatgcat

8941 aaaagccagt tccagcgggg ctgtgcacac tgtcgttcag gtcgcatcct gtacaagtgg

9001 gcctagtgga ggggcacaag cggggactca tccaacccag gcttctctcc tcaagcccca

9061 tgcctagagg aataggaggg cttttccatt tggtttattg ggtgggaaca cttcccaatt

9121 tgccacaaag cactgtaagt ggtggcagtt gttcttgggt gcaagaaccg tcggggagag

9181 gcagctgggt ttccacaggg ggtgtaggca actgataatg aacctcccac ccacacccta

9241 ggccaacaga tcacagaacc ccttcagccc aggtgccttg cagccacacc cactacccac

9301 cccacttctc cacacatgat agcctttctc cctgggtata ggggaagggg gtctgggccg

9361 gagcaagcag ccttaatcct gtgccccctg accactgtcc tggccccagg tgtgaaagcc

9421 tggtggacat ttattcccag ctacagcagg aggtaggggc ggctggtggg gagcttgagc

9481 ccaagacccg ggcatcgctg actggccggc tggatgaagt cctgagaacc ctcgtcacca

9541 ggtattcccc gggagctccc agtctggcct agaacagacc tcgggaagaa aagaaggggg

9601 ctagagctgt ggggagggca ccagcaggga cctagccccc aactcccctt gtgtcctcct

9661 cactcccagt tgcttcctgg tggagaagca gcccccccag gtactgaaga ctcagaccaa g721 gttccaggct ggagttcgat tcctgttggg cttgaggttc ctgggggccc cagccaagcc

9781 tccgctggtc agggccgaca tggtgacaga gaagcaggcg cgggagctga gtgtgcctca

9841 gggtcctggg gctggagcgt aagctgggat tggacctggg gttggagaag ggctgttagg 9901 gtgatggagg cagcctggag ggctggcact gaaaagagea agggatgggg agggagggcc 9g61 atgggatgtg gagaccctga atggtcaagg cagaggaaag ggagggaccc atttagggct

10021 ggaatggggt gggggcatca tgatttggcc aagatgggga ctcctccctt aagaacccaa

10081 acagagacat ggagatttag ggctggtgac agtgggtagt ctacactcac ccatgcactc

10141 gccacacctg acgacagtga gatgagctcg ttcacactct gacctcccct gggcagagaa

10201 agcactggag aaatcatcaa caacactgtg cccttggaga acagcattcc tgggaactgc

10261 tgctctgccc tgttcaagaa cctggtgagg ggctttgggg tgcagtgagg ggggcaccac

10321 taggagactg tgggactctc cttggagagg atgtcaggaa gcccaggagg agcggtctct

10381 gtcctcatga cctcgccctt gctctccctc accccaccca cagcttctca agaagatcaa

10441 gcggtgtgag cggaagggca ctgagtctgt cacagaggag aagtgcgctg tgctcttctc

10501 tgccagcttc acacttggcc ccggcaaact ccccatccag ctccaggtga accgtggccc

10561 agccctgccc caatctggga ccccgagtcc tcctccaatg ccacgcacaa gggccctgga

10621 ccctcacctc ttgtgactgc cccatacccc atgtgtctgg gattcatgca cactggggcc

10681 cgggtgagtg ggggtgagca agagcatgga gtgcacaggg cagggaatgg tagtggatag

10741 cagcaaacac ttcggaagca cttcctatag accaggggca ctctattaaa tgatacatac

10801 tgcacatgcg tgccagcaca cacacgtctg gttttcacaa taacattatg aggtaggcag

10861 tattatcagc ctcattttat agcatgagga cattgagaca gagagtttaa gtagtttgtc

10921 ccagtcaccc agctaagtgt tggagctggt atctgaaacc tggaagtctg gttccatagc

10981 gattatagta accacttctc tacggtgagg ccctgattga gcttcaaaac gcatttaata

11041 acatgg

1 ggaaagaaag aaagaaaaga aaccctgtcc tcaccctact tcaggccctg tctctgcccc

61 tggtggtcat cgtccatggc aaccaagaca acaatgccaa agccactatc ctgtgggaca

121 atgccttctc tgagatggtg aggaaagtcc ttggtagttg gagggaacag ggtgcagggt

181 gggttctaac atgggcagtg gtgcaggcct gctgatgggg tggtgggcat gtcggatggg

241 tgtgacctta acacttcttc atgggcctgc tttcgtgctt ctgacctctt ttcaccccag

301 tcttaacaac tatcaggcca cagcactgta acctagaaaa aacagcatgt ttgtgagcga

361 tatcaggggc tgtggagggg taggccacag gcatgtggga cggatgaagg ccggcccgag

421 gaataacaag acggtagcct gcagtgctct cttcttcccc cttctcccca ggaccgcgtg

481 ccctttgtgg tggctgagcg ggtgccctgg gagaagatgt gtgaaactct gaacctgaag

541 ttcatggctg aggtggggac caaccggggg ctgctcccag agcacttcct cttcctggcc

601 cagaagatct tcaatgacaa cagcctcagt atggaggcct tccagcaccg ttctgtgtcc EPI-109 1081

661 tggtcgcagt tcaacaaggt tcagttctcc

1 gcggccgcga gctctaatac gactcactat agggcgtcga ctcgatcata ccactgcact

61 caagcctggg tgacagagca agactctgtc tcaaaaaaaa aaaaaaaaaa aggccaggca 121 tggtggttca tgcctgtaat cccagcactt tgggaggccg agacggatag atcacctgag 181 gtcaggagtt cgagaccagc ctggccaaca tggcaaaacc ccgtctctac taaaaacaaa 241 aaaatagcca ggatggtcgt ttgcgtctgt aatcccagct actcggctga ggcaggaggt 301 gaacccagga ggtaaaggct gcaggggaag atgaaaccat tgcactccag cctgggcaag 361 actctgtatc aaaaaaaaaa aaaaaaaggc taggtgtggt ggctcacacc tgtaatccca 421 gcactttggg aggctgaggc gggcggatca caaggtcaag aaatcgagac catcctgacc 481 aacatggtga aaccccgtct ctactaaaaa tacaaaaatt acctgggcat ggtggcgcat 541 gcctgtattc ccaactactc gggaggctga ggcatgaaaa tcacttgaac ctgggaggca 601 gaggttgcag gcgagccaag attgtgccac tgcactccag cctgccaaca aaaatgagat 661 tctgtc 1 ggttaccttc cctttgggcg tcaacttctg ccacacctcc ttagggagag ggtgtagcat

61 agtagttaag aggggtccag ggccagaatg cctgggttta aatcctagct ctgcctctta 121 ccagctatgt agacctgggc aagtcattcg acgtttttgg acttccattt cttcatctgt 181 aagatggaat tattataatc cctacttcca tagcctggta aagagcaaat aaatatatgg 241 aaaggcttga aatagtggct ggcacgtgta agcattagga ttggtcgttg tcattgatgg 301 agtctcaggt tcggtctgat cctcagcccc tgtgattctg tcgtgagggc actcacagct 361 cactgcctgc cctaaacagg ctccagctct ggccctccct cggctcacac ctttccccct 421 ctccccctag gagatcctgc tgggccgtgg cttcaccttt tggcagtggt ttgatggtgt 481 cctggacctc accaaacgct gtctccggag ctactggtct gaccggtgag tccccaccct 541 gggtagtttg agcagccata caccagtcac ctccatactc actgcccatg ccccatcctc 601 tccttcatcc cggccaggct gatcattggc ttcatcagca aacagtacgt tactagcctt 661 cttctcaatg agcccgacgg aacctttctc ctccgcttca gcgactcaga gattgggggc 721 atcaccattg cccatgtcat ccggggccag gatggtgagg ccaccccagc cagtcctctg 781 tctctgtgcc tgtgccctct ggggtttctt ctgggaatga aatgtcctga ccttcctgat 841 gccgatcctg atcttcagga agttcttcca gcttctcttc ttccttctgt ggtctaaatg 901 ttcaccttct cactgtgagc tctgtgggaa cggagactag tgggtctctc tccctcagga 961 gccccaccct aggtcctctc tcccttgcct tggtggagtg agaacaggtc ttatggtagg 1021 ggttggggaa ggggaagaaa tccggacaga gggatctcag ggtctccttc ctaccatagg 1081 ctctccacag atagagaaca tccagccatt ctctgccaaa gacctgtcca ttcgctcact 1141 gggggaccga atccgggatc ttgctcagct caaaaatctc tatcccaaga agcccaagga 1201 tgaggctttc cggagccact acaagcgtga gctggaactg gcagctctga ttccttcctg 1261 tcacccactt cctgccatgc tccccgctgc catcctctcc ccagcccgtg agttatcctg 1321 aggtcactcc gaatttccat agctgtgctt ttcttacttc ccggatgatc catgcccacc 1381 ttttccacct cccttcctcc ctaacccgag agcaatccat ggcagtcttt tccatctcac

1441 aacagctgaa cagctgaaca gatgggtaag gatggcaggg gttatgtccc agctaccatc 1501 aagatgaccg tggaaaggtg agtgtggtgg tatggacagt gggtaggtca ggggcttagt 1561 gcttatctgc aggaaggagg ggtggcatca acccttggtc agtcacatgt acctccttcc 1621 ctcctccagg gaccaaccac ttcctacccc agagctccag atgcctacca tggtgccttc 1681 ttatgacctt ggaatggccc ctgattcctc catgagcatg cagcttggcc cagatatggt 1741 gtaaggagct ggaaagacag gaatgggagt ggtctgtgca gatgggctaa tcttagcatg 1801 ggcagctggg agagctggca ctgggggctg aacagggaat cttcctttcc atgagaggga 1861 cacctgttca aaagcagggt gtggtggtgt ccaggagaag ggctggcatc agggggtctg 1921 ttttctttcc ccaggcccca ggtgtaccca ccacactctc actccatccc cccgtatcaa 1981 ggcctctccc cagaagaatc agtcaacgtg ttgtcagcct tccaggagta agtgaaaaac 2041 ctcatgggga taccatccca ctctaagggg gtgggcattt gaattgttag aagaggctct 2101 tctgtgagaa aggagcagca aatgctaaca gcctgtcttc ttctcttctg tccactctaa 2161 tgagggggta gtagttaaga tctggactgc ctaggtttga attctagctc caccacttac 2221 tggtttgggg caaattactt agcctttggt gccttatctg cacaatgggg gataataatg 2281 ctaataataa taacctacct cactgcatta ttgtggagat taaatgagtt cataacactt 2341 aaaaagctcg agcatagtgc atggctcata gcaaaagctg tgtaagtcca gtcgtggatc 2401 acttaatgaa ggagcatttt ctgtctttgg cagtttcata attatgcgga ataccattga 2461 gtataattac acaaacctag atggtataga ctactataca ctgaggctat attgtgtagc 2521 ctattgatcc tagctttaaa cccgagcagc atgatactgt tctgaatagt ataaggaaat 2581 agtaacataa tggtaaatat ttgtgtgata ggaattttca gcttgattat aatttttttt 2641 ttttgagaca gggtctcact cactggagtg cagtggtgcg atcttagctc ccctgcaacc 2701 tccgcctctt gggctcgagc aatcctcctg ctgtagtgca ccacgacact cggctaattc 2761 ttttttaaga tttttctgca ggaaccaaaaggggttcctt cacttactgc ccaagctggt ctcaaactcc 2821 tgggcttaag tgatcctccc aaccccttccggggcccctt cccaaagcgt taggattaca ggcgtgagtc 2881 actctgcctg gccttgatta taatcttatg ggaccactgt ggtctgtagt tgacagaaat 2941 gtcgttaatg tggtgcatga ctgttattat tattttctgt cctgcccctg agagccactg 3001 tcacttctct gctgtattgg tttttgttta ctcatctgtt ttggccttga aatggcctag 3061 acatttttct tcccgaagta tgacactcgg gtgcttatta acttagtcaa gacacaacat 3121 ctcccttccc agaaagtgag gcgggagtga ggacttgggg acttaagaac taccaaagtt 3181 cagagtccaa aggaaacatt agaaattggg taatccaccc ccataacacg cacattttac 3241 agatgagaag actgagctca gagcatagaa atagcttgcc caggccatga ctaagtcagg EPI-109 1082

3301 ataaggagct ggagcttgtt tcctcactca gtggtcctga ctttgcacca ctctgcattt 3361 gcctagcctg ccttcctcta actgtgctct ccctacttcc aggcctcacc tgcagatgcc 3421 ccccagcctg ggccagatga acctgccctt tgaccagcct cacccccagg tgaatgacaa 3481 aagcccctcc tgacccatgt gcctcttctt tcctgggcct tgcccgctct ccttatttcc 3541 attgctggtt cctggcaggg cctgctgccg tgccagcctc aggagcatgc tgtgtccagc 3601 cctgaccccc tgctctgctc agatgtgacc atggtggaag acagctgcct gagccagcca

3661 gtgacagcgt ttcctcaggg cacttggtga gtggcagctt gggagtggag gctgggtggc 3721 atctagggga gtgggcgcca tgcctactcc actgcttctc ccatctcctt gcaggattgg 3781 tgaagacata ttccctcctc tgctgcctcc cactgaacag gacctcacta agcttctcct 3841 ggaggggcaa ggggagtcgg ggggagggtc cttgggggca cagcccctcc tgcagccctc 3901 ccactatggg caatctggga tctcaatgtc ccacatggac ctaagggcca accccagttg 3961 gtgatcccag ctggagggag aacccaaaga gacagctctt ctactacccc cacagacctg 4021 ctctggacac ttgctcatgc cctgccaagc agcagatggg gagggtgccc tcctatcccc 4081 acctactcct gggtcaggag gaaaagacta acaggagaat gcacagtggg tggagccaat 4141 ccactccttc ctttctatca ttcccctgcc cacctccttc cagcactgac tggaagggaa 4201 gttcaggctc tgagacacgc cccaacatgc ctgcacctgc agcgcgcaca cgcacgcaca 4261 cacacataca gagctctctg agggtgatgg ggctgagcag gaggggggct gggtaagagc 4321 acaggttagg gcatggaagg cttctccgcc cattctgacc cagggcctag gacggatagg 4381 caggaacata cagacacatt tacactagag gccagggata gaggatattg ggtctcagcc 4441 ctaggggaat gggaagcagc tgaagggacc ctgggtggga gcataggagg agtctggaca 4501 tgtggttact agtacaggtt ttgccctgat taaaaaatct cccaaagccc caaattcctg 4561 ttagccaggt ggaggcttct gatacgtgta tgagactatg caaaagtaca agggctgaga

4621 ttcttcgtgt atagctgtgt gaacgtgtat gtacctagga tatgttaaat atatagctgg 4681 caccttagtt gcatgaccac atagaacatg tgtctatctg cttttgccta cgtgacaaca 4741 caaatttggg agggtgagac actgcacaga agacagcagc aagtgtgctg gcctctctga 4801 catatgctaa cccccaaata ctctgaattt ggagtctgac tgtgcccaag tgggtccaag 4861 tggctgtgac atctacgtat ggctccacac ctccaatgct gcctgggagc cagggtgaga 4921 gtctgggtcc aggcctggcc atgtggccct ccagtgtatg agagggccct gcctgctgca 4981 tcttttctgt tgccccatcc accgccagct tcccttcact cccctatccc attctccctc 5041 tcaaggcagg ggtcatagat cctaagccat aaaataaatt ttattccaaa ataacaaaat 5101 aaataatcta ctgtacacaa tctgaaaaga aagacgctct aactgctcag ataggtgctg 5161 cggtccagcc cccagctgga ggagaccctg agtccaaccc aggcctcccg agggggccag 5221 tgaagggatc ccacacccac cgcccctatg tagggcaggg aagaaattgc aaaggacttg 5281 ggggatagat gggaatggga gggcaaactg cagcacttgt taaattaatt aaagaaacaa 5341 accagaagca caaaaacggg gaaggagaag ggagaaggag caggtccagt gttccaggcc 5401 ccaattctgg gggcaaatgt gcca

1 gcagcaccta tctgagcagt tagagcgtct ttcttttcag attgtgtaca gtagattatt

61 tattttgtta ttttggaata aaatttattt tatggcttag gatctatgac ccctgccttg

121 agagggagaa tgggataggg gagtgaaggg aagctggcgg tggatggggc aacagaaaag

181 atgcagcagg cagggccctc tcatacactg gagggccaca tggccaggcc tggacccaga

241 ctctcaccct ggctcccagg cagcattgga ggtgtggagc catacgtaga tgtcacagcc

301 acttggaccc acttgggcac agtcagactc caaattcaga gtatttgggg gttagcatat

361 gtcagagagg ccagcacact tgctgctgtc ttctgtgcag tgtctcaccc tcccaaattt

421 gtgttgtcac gtaggcaaaa gcagatagac acatgttcta tgtggtcatg caactaaggt

481 gccagctata catttaacat atcctaggta catacacgtt cacacagcta tacacgaaga

541 atctcagccc ttgtactttt gcatagtctc atacacgtat cagaagcctc cacctggcta

601 acaggaattt ggggctttgg gagatttttt aatcagggca aaacctgtac tagtaaccac

661 atgtccagac ccctcctatg ctcccaccca gggtcccttg agctgcttcc cattccccta

721 gggctgagac ccaatatcct ctatccctgg cctctagtgt aaatgtgtct gtatgttcct

781 gcctatccgt cctaggccct gggtcagaat gggcggagaa gccttccatg ccctaacctg

841 tgctcttacc cagcccccct cctgctcagc cccatcaccc tcagagagct ctgtatgtgt

901 gtgtgcgtgc gtgtgcgcgc tgcaggtgca ggcatgttgg ggtgtgtctc agagcctgaa

961 cttcccttcc agtcagtact ggaaggaggt gggcagggga atgatagaaa ggaaggagtg

1021 gattggctcc acccactgtg cattctcctg ttagtctttt cctcctgacc caggagtagg

1081 tggggatagg agggcaccct ccccatctgc tgcttggcag ggcatgagca agtgtccaga

1141 gcaggtctgt gggggtagta gaagagctgt ctctttgggt tctccctcca gctgggatca

1201 ccaactgggg ttggccctta ggtccatgtg ggacattgag atcccagatt gcccatagtg

1261 ggagggctgc aggaggggct gtgcccccaa ggaccctccc cccgactccc cttgcccctc

1321 caggagaagc ttagtgaggt cctgttcagt gggaggcagc agaggaggga atatgtcttc

1381 accaatcctg caaggagatg ggagaagcag tggagtaggc atggcgccca ctcccctaga

1441 tgccacccag cctccactcc caagctgcca ctcac

INFORMATION FOR SEQ ID NO: 2813: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2813 EPI-109 1083

1 cgccatcccg cgctctgcgg actgggaggc ccgggccagg acgcgagtct gcgcagccga

61 ggttccccag cgccccctgc agccgcgcgt aggcagagac ggagcccggc cctgcgcctc

121 cgcaccacgc ccgggacccc acccagcggc ccgtacccgg agaagcagcg cgagcacccg

181 aagctcccgg ctcggcggca gaaaccggga gtggggccgg gcgagtgcgc ggcatcccag

241 gccggcccga acgtccgccc gcggtgggcc gacttcccct cctcttccct ctctccttcc

301 tttagcccgc tggcgccgga cacgctgcgc ctcatctctt ggggcgttct tccccgttgg

361 ccaaccgtcg catcccgtgc aactttgggg tagtggccgc ttagtgttga atgttcccca

421 ccgagagcgc atggcttggg aagcgaggcg cgaacccggg ccccgaagcc gccgtccggg

481 agacggtgat gctgttgctg tgcctggggg tcccgaccgg ccgcccctac aacgtggaca

541 ctgagagcgc gctgctttac cagggccccc acaacacgct gttcggctac tcggtcgtgc

601 tgcacagcca cggggcgaac cgatggctcc tagtgggtgc gcccactgcc aactggctcg

661 ccaacgcttc agtgatcaat cccggggcga tttacagatg caggatcgga aagaatcccg

721 gccagacgtg cgaacagctc cagctgggta gccctaatgg agaaccttgt ggaaagactt

781 gtttggaaga gagagacaat cagtggttgg gggtcacact ttccagacag ccaggagaaa

841 atggatccat cgtgacttgt gggcatagat ggaaaaatat attttacata aagaatgaaa

901 ataagctccc cactggtggt tgctatggag tgccccctga tttacgaaca gaactgagta

961 aaagaatagc tccgtgttat caagattatg tgaaaaaatt tggagaaaat tttgcatcat

1021 gtcaagctgg aatatccagt ttttacacaa aggatttaat tgtgatgggg gccccaggat

1081 catcttactg gactggctct ctttttgtct acaatataac tacaaataaa tacaaggctt

1141 ttttagacaa acaaaatcaa gtaaaatttg gaagttattt aggatattca gtcggagctg

1201 gtcattttcg gagccagcat actaccgaag tagtcggagg agctcctcaa catgagcaga

1261 ttggtaaggc atatatattc agcattgatg aaaaagaact aaatatctta catgaaatga

1321 aaggtaaaaa gcttggatcg tactttggag cttctgtctg tgctgtggac ctcaatgcag

1381 atggcttctc agatctgctc gtgggagcac ccatgcagag caccatcaga gaggaaggaa

1441 gagtgtttgt gtacatcaac tctggctcgg gagcagtaat gaatgcaatg gaaacaaacc

1501 tcgttggaag tgacaaatat gctgcaagat ttggggaatc tatagttaat cttggcgaca

1561 ttgacaatga tggctttgaa gatgttgcta tcggagctcc acaagaagat gacttgcaag

1621 gtgctattta tatttacaat ggccgtgcag atgggatctc gtcaaccttc tcacagagaa

1681 ttgaaggact tcagatcagc aaatcgttaa gtatgtttgg acagtctata tcaggacaaa

1741 ttgatgcaga taataatggc tatgtagatg tagcagttgg tgcttttcgg tctgattctg

1801 ctgtcttgct aaggacaaga cctgtagtaa ttgttgacgc ttctttaagc caccctgagt

1861 cagtaaatag aacgaaattt gactgtgttg aaaatggatg gccttctgtg tgcatagatc

1921 taacactttg tttctcatat aagggcaagg aagttccagg ttacattgtt ttgttttata

1981 acatgagttt ggatgtgaac agaaaggcag agtctccacc aagattctat ttctcttcta

2041 atggaacttc tgacgtgatt acaggaagca tacaggtgtc cagcagagaa gctaactgta

2101 gaacacatca agcatttatg cggaaagatg tgcgggacat cctcacccca attcagattg

2161 aagctgctta ccaccttggt cctcatgtca tcagtaaacg aagtacagag gaattcccac

2221 cacttcagcc aattcttcag cagaagaaag aaaaagacat aatgaaaaaa acaataaact

2281 ttgcaaggtt ttgtgcccat gaaaattgtt ctgctgattt acaggtttct gcaaagattg

2341 ggtttttgaa gccccatgaa aataaaacat atcttgctgt tgggagtatg aagacattga

2401 tgttgaatgt gtccttgttt aatgctggag atgatgcata tgaaacgact ctacatgtca

2461 aactacccgt gggtctttat ttcattaaga ttttagagct ggaagagaag caaataaact

2521 gtgaagtcac agataactct ggcgtggtac aacttgactg cagtattggc tatatatatg

2581 tagatcatct ctcaaggata gatattagct ttctcctgga tgtgagctca ctcagcagag

2641 cggaagagga cctcagtatc acagtgcatg ctacctgtga aaatgaagag gaaatggaca

2701 atctaaagca cagcagagtg actgtagcaa tacctttaaa atatgaggtt aagctgactg

2761 ttcatgggtt tgtaaaccca acttcatttg tgtatggatc aaatgatgaa aatgagcctg

2821 aaacgtgcat ggtggagaaa atgaacttaa ctttccatgt tatcaacact ggcaatagta

2881 tggctcccaa tgttagtgtg gaaataatgg taccaaattc ttttagcccc caaactgata

2941 agctgttcaa cattttggat gtccagacta ctactggaga atgccacttt gaaaattatc

3001 aaagagtgtg tgcattagag cagcaaaaga gtgcaatgca gaccttgaaa ggcatagtcc

3061 agttcttgtc caagactgat aagaggctat tgtactgcat aaaagctgat ccacattgtt

3121 taaatttctt gtgtaatttt gggaaaatgg aaagtggaaa agaagccagt gttcatatcc

3181 aactggaagg ccggccatcc attttagaaa tggatgagac ttcagcactc aagtttgaaa

3241 taagagcaac aggttttcca gagccaaatc caagagtaat tgaactaaac aaggatgaga

3301 atgttgcgca tgttctactg gaaggactac atcatcaaag acccaaacgt tatttcacca

3361 tagtgattat ttcaagtagc ttgctacttg gacttattgt acttctgttg atctcatatg

3421 ttatgtggaa ggctggcttc tttaaaagac aatacaaatc tatcctacaa gaagaaaaca

3481 gaagagacag ttggagttat atcaacagta aaagcaatga tgattaagga cttctttcaa

3541 attgagagaa tggaaaacag cccgccc

(2) INFORMATION FOR SEQ ID NO:2814: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2814 1 gaattccggg ccgcttagtg ttgaatgttc cccaccgaga gcgcatggct tgggaagcga EPI-109 1084

61 ggcgcgaacc cgggccccga agccgccgtc cgggagacgg tgatgctgtt gctgtgcctg

121 ggggtcccga ccggccgccc ctacaacgtg gacactgaga gcgcgctgct ttaccagggc

181 ccccacaaca cgctgttcgg ctactcggtc gtgctgcaca gccacggggc gaaccgatgg

241 ctcctagtgg gtgcgcccac tgccaactgg ctcgccaacg cttcagtgat caatcccggg

301 gcgatttaca gatgcaggat cggaaagaat cccggccaga cgtgcgaaca gctccagctg

361 ggtagcccta atggagaacc ttgtggaaag acttgtttgg aagagagaga caatcagtgg

421 ttgggggtca cactttccag acagccagga gaaaatggat ccatcgtgac ttgtgggcat

481 agatggaaaa atatatttta cataaagaat gaaaataagc tccccactgg tggttgctat

541 ggagtgcccc ctgatttacg aacagaactg agtaaaagaa tagctccgtg ttatcaagat

601 tatgtgaaaa aatttggaga aaattttgca tcatgtcaag ctggaatatc cagtttttac

661 acaaaggatt taattgtgat gggggcccca ggatcatctt actggactgg ctctcttttt

721 gtctacaata taactacaaa taaatacaag gcttttttag acaaacaaaa tcaagtaaaa

781 tttggaagtt atttaggata ttcagtcgga gctggtcatt ttcggagcca gcatactacc

841 gaagtagtcg gaggagctcc tcaacatgag cagattggta aggcatatat attcagcatt

901 gatgaaaaag aactaaatat cttacatgaa atgaaaggta aaaagcttgg atcgtacttt

961 ggagcttctg tctgtgctgt ggacctcaat gcagatggct tctcagatct gctcgtggga

1021 gcacccatgc agagcaccat cagagaggaa ggaagagtgt ttgtgtacat caactctggc

1081 tcgggagcag taatgaatgc aatggaaaca aacctcgttg gaagtgacaa atatgctgca

1141 agatttgggg aatctatagt taatcttggc gacattgaca atgatggctt tgaagatgtt

1201 gctatcggag ctccacaaga agatgacttg caaggtgcta tttatattta caatggccgt

1261 gcagatggga tctcgtcaac cttctcacag agaattgaag gacttcagat cagcaaatcg

1321 ttaagtatgt ttggacagtc tatatcagga caaattgatg cagataataa tggctatgta

1381 gatgtagcag ttggtgcttt tcggtctgat tctgctgtct tgctaaggac aagacctgta

1441 gtaattgttg acgcttcttt aagccaccct gagtcagtaa atagaacgaa atttgactgt

1501 gttgaaaatg gatggccttc tgtgtgcata gatctaacac tttgtttctc atataagggc

1561 aaggaagttc caggttacat tgttttgttt tataacatga gtttggatgt gaacagaaag

1621 gcagagtctc caccaagatt ctatttctct tctaatggaa cttctgacgt gattacagga

1681 agcatacagg tgtccagcag agaagctaac tgtagaacac atcaagcatt tatgcggaaa

1741 gatgtgcggg acatcctcac cccaattcag attgaagctg cttaccacct tggtcctcat

1801 gtcatcagta aacgaagtac agaggaattc ccaccacttc agccaattct tcagcagaag

1861 aaagaaaaag acataatgaa aaaaacaata aactttgcaa ggttttgtgc ccatgaaaat

1921 tgttctgctg atttacaggt ttctgcaaag attgggtttt tgaagcccca tgaaaataaa

1981 acatatcttg ctgttgggag tatgaagaca ttgatgttga atgtgtcctt gtttaatgct

2041 ggagatgatg catatgaaac gactctacat gtcaaactac ccgtgggtct ttatttcatt

2101 aagattttag agctggaaga gaagcaaata aactgtgaag tcacagataa ctctggcgtg

2161 gtacaacttg actgcagtat tggctatata tatgtagatc atctctcaag gatagatatt

2221 agctttctcc tggatgtgag ctcactcagc agagcggaag aggacctcag tatcacagtg

2281 catgctacct gtgaaaatga agaggaaatg gacaatctaa agcacagcag agtgactgta

2341 gcaatacctt taaaatatga ggttaagctg actgttcatg ggtttgtaaa cccaacttca

2401 tttgtgtatg gatcaaatga tgaaaatgag cctgaaacgt gcatggtgga gaaaatgaac

2461 ttaactttcc atgttatcaa cactggcaat agtatggctc ccaatgttag tgtggaaata

2521 atggtaccaa attcttttag cccccaaact gataagctgt tcaacatttt ggatgtccag

2581 actactactg gagaatgcca ctttgaaaat tatcaaagag tgtgtgcatt agagcagcaa

2641 aagagtgcaa tgcagacctt gaaaggcata gtccggttct tgtccaagac tgataagagg

2701 ctattgtact gcataaaagc tgatccacat tgtttaaatt tcttgtgtaa ttttgggaaa

2761 atggaaagtg gaaaagaagc cagtgttcat atccaactgg aaggccggcc atccatttta

2821 gaaatggatg agacttcagc actcaagttt gaaataagag caacaggttt tccagagcca

2881 aatccaagag taattgaac^'t aaacaaggat gagaatgttg cgcatgttct actggaagga

2941 ctacatcatc aaagacccaa acgttatttc accatagtga ttatttcaag tagcttgcta

3001 cttggactta ttgtacttct gttgatctca tatgttatgt ggaaggctgg cttctttaaa

3061 agacaataca aatctatcct acaagaagaa aacagaagag acagttggag ttatatcaac

3121 agtaaaagca atgatgatta aggacttctt tcaaattgag agaatggaaa acagactcag

3181 gttgtagtaa agaaatttaa aagacactgt ttacaagaaa aaatgaattt tgtttggact

3241 tcttttactc atgatcttgt gacatattat gtcttcatgc aaggggaaaa tctcagcaat

3301 gattactctt tgagatagaa gaactgcaaa ggtaataata cagccaaaga taatctctca

3361 gcttttaaat gggtagagaa acactaaagc attcaattta ttcaagaaaa gtaagccctt

3421 gaagatatct tgaaatgaaa gtataactga gttaaattat actggagaag tcttagactt

3481 gaaatactac ttaccatatg tgcttgcctc agtaaaatga accccactgg gtgggcagag

3541 gttcatttca aatacatctt tgatacttgt tcaaaatatg ttctttaaaa atataatttt

3601 ttagagagct gttcccaaat tttctaacga gtggaccatt atcactttaa agccctttat

3661 ttataataca tttcctacgg gctgtgttcc aacaaccatt ttttttcagc agactatgaa

3721 tattatagta ttataggcca aactggcaaa cttcagactg aacatgtaca ctggtttgag

3781 cttagtgaaa tgacttccgg aatct

(2) INFORMATION FOR SEQ ID NO: 2815: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single EPI-109 1085

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2815

1 cgccatcccg cgctctgcgg actgggaggc ccgggccagg acgcgagtct gcgcagccga

61 ggttccccag cgccccctgc agccgcgcgt aggcagagac ggagcccggc cctgcgcctc

121 cgcaccacgc ccgggacccc acccagcggc ccgtacccgg agaagcagcg cgagcacccg

181 aagctcccgg ctcggcggca gaaaccggga gtggggccgg gcgagtgcgc ggcatcccag

241 gccggcccga acgtccgccc gcggtgggcc gacttcccct cctcttccct ctctccttcc

301 tttagcccgc tggcgccgga cacgctgcgc ctcatctctt ggggcgttct tccccgttgg

361 ccaaccgtcg catcccgtgc aactttgggg tagtggccgc ttagtgttga atgttcccca

421 ccgagagcgc atggcttggg aagcgaggcg cgaacccggg ccccgaagcc gccgtccggg

481 agacggtgat gctgttgctg tgcctggggg tcccgaccgg ccgcccctac aacgtggaca

541 ctgagagcgc gctgctttac cagggccccc acaacacgct gttcggctac tcggtcgtgc

601 tgcacagcca cggggcgaac cgatggctcc tagtgggtgc gcccactgcc aactggctcg

661 ccaacgcttc agtgatcaat cccggggcga tttacagatg caggatcgga aagaatcccg

721 gccagacgtg cgaacagctc cagctgggta gccctaatgg agaaccttgt ggaaagactt

781 gtttggaaga gagagacaat cagtggttgg gggtcacact ttccagacag ccaggagaaa

841 atggatccat cgtgacttgt gggcatagat ggaaaaatat attttacata aagaatgaaa

901 ataagctccc cactggtggt tgctatggag tgccccctga tttacgaaca gaactgagta

961 aaagaatagc tccgtgttat caagattatg tgaaaaaatt tggagaaaat tttgcatcat

1021 gtcaagctgg aatatccagt ttttacacaa aggatttaat tgtgatgggg gccccaggat

1081 catcttactg gactggctct ctttttgtct acaatataac tacaaataaa tacaaggctt

1141 ttttagacaa acaaaatcaa gtaaaatttg gaagttattt aggatattca gtcggagctg

1201 gtcattttcg gagccagcat actaccgaag tagtcggagg agctcctcaa catgagcaga

1261 ttggtaaggc atatatattc agcattgatg aaaaagaact aaatatctta catgaaatga

1321 aaggtaaaaa gcttggatcg tactttggag cttctgtctg tgctgtggac ctcaatgcag

1381 atggcttctc agatctgctc gtgggagcac ccatgcagag caccatcaga gaggaaggaa

1441 gagtgtttgt gtacatcaac tctggctcgg gagcagtaat gaatgcaatg gaaacaaacc

1501 tcgttggaag tgacaaatat gctgcaagat ttggggaatc tatagttaat cttggcgaca

1561 ttgacaatga tggctttgaa gatgttgcta tcggagctcc acaagaagat gacttgcaag

1621 gtgctattta tatttacaat ggccgtgcag atgggatctc gtcaaccttc tcacagagaa

1681 ttgaaggact tcagatcagc aaatcgttaa gtatgtttgg acagtctata tcaggacaaa

1741 ttgatgcaga taataatggc tatgtagatg tagcagttgg tgcttttcgg tctgattctg

1801 ctgtcttgct aaggacaaga cctgtagtaa ttgttgacgc ttctttaagc caccctgagt

1861 cagtaaatag aacgaaattt gactgtgttg aaaatggatg gccttctgtg tgcatagatc

1921 taacactttg tttctcatat aagggcaagg aagttccagg ttacattgtt ttgttttata

1981 acatgagttt ggatgtgaac agaaaggcag agtctccacc aagattctat ttctcttcta

2041 atggaacttc tgacgtgatt acaggaagca tacaggtgtc cagcagagaa gctaactgta

2101 gaacacatca agcatttatg cggaaagatg tgcgggacat cctcacccca attcagattg

2161 aagctgctta ccaccttggt cctcatgtca tcagtaaacg aagtacagag gaattcccac

2221 cacttcagcc aattcttcag cagaagaaag aaaaagacat aatgaaaaaa acaataaact

2281 ttgcaaggtt ttgtgcccat gaaaattgtt ctgctgattt acaggtttct gcaaagattg

2341 ggtttttgaa gccccatgaa aataaaacat atcttgctgt tgggagtatg aagacattga

2401 tgttgaatgt gtccttgttt aatgctggag atgatgcata tgaaacgact ctacatgtca

2461 aactacccgt gggtctttat ttcattaaga ttttagagct ggaagagaag caaataaact

2521 gtgaagtcac agataactct ggcgtggtac aacttgactg cagtattggc tatatatatg

2581 tagatcatct ctcaaggata gatattagct ttctcctgga tgtgagctca ctcagcagag

2641 cggaagagga cctcagtatc acagtgcatg ctacctgtga aaatgaagag gaaatggaca

2701 atctaaagca cagcagagtg actgtagcaa tacctttaaa atatgaggtt aagctgactg

2761 ttcatgggtt tgtaaaccca acttcatttg tgtatggatc aaatgatgaa aatgagcctg

2821 aaacgtgcat ggtggagaaa atgaacttaa ctttccatgt tatcaacact ggcaatagta

2881 tggctcccaa tgttagtgtg gaaataatgg taccaaattc ttttagcccc caaactgata

2941 agctgttcaa cattttggat gtccagacta ctactggaga atgccacttt gaaaattatc

3001 aaagagtgtg tgcattagag cagcaaaaga gtgcaatgca gaccttgaaa ggcatagtcc

3061 agttcttgtc caagactgat aagaggctat tgtactgcat aaaagctgat ccacattgtt

3121 taaatttctt gtgtaatttt gggaaaatgg aaagtggaaa agaagccagt gttcatatcc

3181 aactggaagg ccggccatcc attttagaaa tggatgagac ttcagcactc aagtttgaaa

3241 taagagcaac aggttttcca gagccaaatc caagagtaat tgaactaaac aaggatgaga

3301 atgttgcgca tgttctactg gaaggactac atcatcaaag acccaaacgt tatttcacca

3361 tagtgattat ttcaagtagc ttgctacttg gacttattgt acttctgttg atctcatatg

3421 ttatgtggaa ggctggcttc tttaaaagac aatacaaatc tatcctacaa gaagaaaaca

3481 gaagagacag ttggagttat atcaacagta aaagcaatga tgattaagga cttctttcaa

3541 attgagagaa tggaaaacag cccgccc

1 gaattccggg ccgcttagtg ttgaatgttc cccaccgaga gcgcatggct tgggaagcga

61 ggcgcgaacc cgggccccga agccgccgtc cgggagacgg tgatgctgtt gctgtgcctg

121 ggggtcccga ccggccgccc ctacaacgtg gacactgaga gcgcgctgct ttaccagggc

181 ccccacaaca cgctgttcgg ctactcggtc gtgctgcaca gccacggggc gaaccgatgg

241 ctcctagtgg gtgcgcccac tgccaactgg ctcgccaacg cttcagtgat caatcccggg

301 gcgatttaca gatgcaggat cggaaagaat cccggccaga cgtgcgaaca gctccagctg EPI-109 1086

361 ggtagcccta atggagaacc ttgtggaaag acttgtttgg aagagagaga caatcagtgg 421 ttgggggtca cactttccag acagccagga gaaaatggat ccatcgtgac ttgtgggcat 481 agatggaaaa atatatttta cataaagaat gaaaataagc tccccactgg tggttgctat 541 ggagtgcccc ctgatttacg aacagaactg agtaaaagaa tagctccgtg ttatcaagat 601 tatgtgaaaa aatttggaga aaattttgca tcatgtcaag ctggaatatc cagtttttac 661 acaaaggatt taattgtgat gggggcccca ggatcatctt actggactgg ctctcttttt 721 gtctacaata taactacaaa taaatacaag gcttttttag acaaacaaaa tcaagtaaaa 781 tttggaagtt atttaggata ttcagtcgga gctggtcatt ttcggagcca gcatactacc 841 gaagtagtcg gaggagctcc tcaacatgag cagattggta aggcatatat attcagcatt 901 gatgaaaaag aactaaatat cttacatgaa atgaaaggta aaaagcttgg atcgtacttt 961 ggagcttctg tctgtgctgt ggacctcaat gcagatggct tctcagatct gctcgtggga 1021 gcacccatgc agagcaccat cagagaggaa ggaagagtgt ttgtgtacat caactctggc 1081 tcgggagcag taatgaatgc aatggaaaca aacctcgttg gaagtgacaa atatgctgca 1141 agatttgggg aatctatagt taatcttggc gacattgaca atgatggctt tgaagatgtt 1201 gctatcggag ctccacaaga agatgacttg caaggtgcta tttatattta caatggccgt 1261 gcagatggga tctcgtcaac cttctcacag agaattgaag gacttcagat cagcaaatcg 1321 ttaagtatgt ttggacagtc tatatcagga caaattgatg cagataataa tggctatgta 1381 gatgtagcag ttggtgcttt tcggtctgat tctgctgtct tgctaaggac aagacctgta 1441 gtaattgttg acgcttcttt aagccaccct gagtcagtaa atagaacgaa atttgactgt 1501 gttgaaaatg gatggccttc tgtgtgcata gatctaacac tttgtttctc atataagggc 1561 aaggaagttc caggttacat tgttttgttt tataacatga gtttggatgt gaacagaaag 1621 gcagagtctc caccaagatt ctatttctct tctaatggaa cttctgacgt gattacagga 1681 agcatacagg tgtccagcag agaagctaac tgtagaacac atcaagcatt tatgcggaaa 1741 gatgtgcggg acatcctcac cccaattcag attgaagctg cttaccacct tggtcctcat 1801 gtcatcagta aacgaagtac agaggaattc ccaccacttc agccaattct tcagcagaag 1861 aaagaaaaag acataatgaa aaaaacaata aactttgcaa ggttttgtgc ccatgaaaat 1921 tgttctgctg atttacaggt ttctgcaaag attgggtttt tgaagcccca tgaaaataaa 1981 acatatcttg ctgttgggag tatgaagaca ttgatgttga atgtgtcctt gtttaatgct 2041 ggagatgatg catatgaaac gactctacat gtcaaactac ccgtgggtct ttatttcatt 2101 aagattttag agctggaaga gaagcaaata aactgtgaag tcacagataa ctctggcgtg 2161 gtacaacttg actgcagtat tggctatata tatgtagatc atctctcaag gatagatatt 2221 agctttctcc tggatgtgag ctcactcagc agagcggaag aggacctcag tatcacagtg 2281 catgctacct gtgaaaatga agaggaaatg gacaatctaa agcacagcag agtgactgta 2341 gcaatacctt taaaatatga ggttaagctg actgttcatg ggtttgtaaa cccaacttca 2401 tttgtgtatg gatcaaatga tgaaaatgag cctgaaacgt gcatggtgga gaaaatgaac 2461 ttaactttcc atgttatcaa cactggcaat agtatggctc ccaatgttag tgtggaaata 2521 atggtaccaa attcttttag cccccaaact gataagctgt tcaacatttt ggatgtccag 2581 actactactg gagaatgcca ctttgaaaat tatcaaagag tgtgtgcatt agagcagcaa 2641 aagagtgcaa tgcagacctt gaaaggcata gtccggttct tgtccaagac tgataagagg 2701 ctattgtact gcataaaagc tgatccacat tgtttaaatt tcttgtgtaa ttttgggaaa 2761 atggaaagtg gaaaagaagc cagtgttcat atccaactgg aaggccggcc atccatttta 2821 gaaatggatg agacttcagc actcaagttt gaaataagag caacaggttt tccagagcca 2881 aatccaagag taattgaact aaacaaggat gagaatgttg cgcatgttct actggaagga 2941 ctacatcatc aaagacccaa acgttatttc accatagtga ttatttcaag tagcttgcta 3001 cttggactta ttgtacttct gttgatctca tatgttatgt ggaaggctgg cttctttaaa 3061 agacaataca aatctatcct acaagaagaa aacagaagag acagttggag ttatatcaac 3121 agtaaaagca atgatgatta aggacttctt tcaaattgag agaatggaaa acagactcag 3181 gttgtagtaa agaaatttaa aagacactgt ttacaagaaa aaatgaattt tgtttggact 3241 tcttttactc atgatcttgt gacatattat gtcttcatgc aaggggaaaa tctcagcaat 3301 gattactctt tgagatagaa gaactgcaaa ggtaataata cagccaaaga taatctctca 3361 gcttttaaat gggtagagaa acactaaagc attcaattta ttcaagaaaa gtaagccctt 3421 gaagatatct tgaaatgaaa gtataactga gttaaattat actggagaag tcttagactt 3481 gaaatactac ttaccatatg tgcttgcctc agtaaaatga accccactgg gtgggcagag 3541 gttcatttca aatacatctt tgatacttgt tcaaaatatg ttctttaaaa atataatttt 3601 ttagagagct gttcccaaat tttctaacga gtggaccatt atcactttaa agccctttat 3661 ttataataca tttcctacgg gctgtgttcc aacaaccatt ttttttcagc agactatgaa 3721 tattatagta ttataggcca aactggcaaa cttcagactg aacatgtaca ctggtttgag 3781 cttagtgaaa tgacttccgg aatct

(2) INFORMATION FOR SEQ ID NO:2816: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2816

(2) INFORMATION FOR SEQ ID NO: 2817: EPI-109 1087

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2817

(2) INFORMATION FOR SEQ ID NO: 2818: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2818

(2) INFORMATION FOR SEQ ID NO:2819: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: _ base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2819

(2) INFORMATION FOR SEQ ID NO:l: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1108 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:l:

1 cagctgtccc tccccactgc catttattcc ttccttcatt caaaccttat gtggctgcta 61 cttaccgtgt gttaagtgtt cacttttttt cttggaattc aaaaaaagaa ggacagtatt 121 tggggcacag atcttttggt gttctataca tttttttaaa gtttcatttt acatttgtgt 181 gtgcgtgtgt gtgtgtgtgt gagacagtct tgctctgttg cccaggctgg agtgcagtgg 241 cataatcatt ggctcactgt agcctcaaag tcctgggccc aagcgatctt cccacctcag 301 ccacccaaaa tgctggggtt acaggtttat gccactctgt ctgacctgaa agttttgggt 361 ttactttccc ttctttctct ttgctgaagt cagagatgat ggcagcttcc agattctctg 421 gtgcctgtgc tgggctcgtg ctggtcatgg tcttgggtcc aggattcatt ctggagactc 481 tcagggaagt ttcccatgac aaggaaatgt aggagagtgt gctggctttg cgtgctcctc 541 tgccaagccc tgcttctcct ggtgggacac actgaaccac agccagggca ttttggtggt 601 tagttaaaaa aaaaaaaaaa aaaaaaaagg aagaagaagg cactgtgtaa ttgtgccggg 661 gatcttcaga aattgtaatg atgaaagagt gcaagctctc acttcccctt cctgtacagg 721 gcaggttgtg cagctggagg cagagcagtc ctctctgggg agcctgaagc aaacatggat 781 caagaaactg taggcaatgt tgtcctgttg gccatcgtca ccctcatcag cgtggtccag 841 aatggtaagg aaagcccttc actcagggaa gaacagaagg ggagattttc tttgatggtt 901 gtttggaagt caggcttaaa caattgtgtc tgtgtgtgcg catgcacaaa cacttttacc 961 ttatctttat tttcttcttt ttatttgaat gtatagggtt gtgtgtattt ctgtgtaaat

1021 ttggggtttt cctcctctta gtctttcact tttgtggtga ttaccagtcc catttttaga

1081 gccagggctg caacttgaag gttttgct

(2) INFORMATION FOR SEQ ID NO: 2: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 540 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2: 1 tgcgttttgg gggttcctgg agtatcaatc atggatcaag aaactgtagg caatgttgtc

61 ctgttggcca tcgtcaccct catcagcgtg gtccagaatg gattctttgc ccataaagtg 121 gagcacgaaa gcaggaccca gaatgggagg agcttccaga ggaccggaac acttgccttt 181 gagcgggtct acactgccaa ccagaactgt gtagatgcgt accccacttt cctcgctgtg 241 ctctggtctg cggggctact ttgcagccaa gttcctgctg cgtttgctgg actgatgtac 301 ttgtttgtgc ggcaaaagta ctttgtcggt tacctaggag agagaacgca gagcacccct 361 ggctacatat ttgggaaacg catcatactc ttcctgttcc tcatgtccgt tgctggcata 421 ttcaactatt acctcatctt ctttttcgga agtgactttg aaaactacat aaagacgatc 481 tccaccacca tctcccctct acttctcatt tcctaactct ctgctgaata tggggttggt

(2) INFORMATION FOR SEQ ID NO: 3: EPI-109 1088

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2022 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3: 1 atgccctcct acacggtcac cgtggccact ggcagccagt ggttcgccgg cactgacgac

61 tacatctacc tcagcctcgt gggctcggcg ggctgcagcg agaagcacct gctggacaag

121 cccttctaca acgacttcga gcgtggcgcg gtggattcat acgacgtgac tgtggacgag

181 gaactgggcg agatccagct ggtcagaatc gagaagcgca agtactggct gaatgacgac

241 tggtacctga agtacatcac gctgaagacg ccccacgggg actacatcga gttcccctgc

301 taccgctgga tcaccggcga tgtcgaggtt gtcctgaggg atggacgcgc aaagttggcc

361 cgagatgacc aaattcacat tctcaagcaa caccgacgta aagaactgga aacacggcaa

421 aaacaatatc gatggatgga gtggaaccct ggcttcccct tgagcatcga tgccaaatgc

481 cacaaggatt taccccgtga tatccagttt gatagtgaaa aaggagtgga ctttgttctg

541 aattactcca aagcgatgga gaacctgttc atcaaccgct tcatgcacat gttccagtct

601 tcttggaatg acttcgccga ctttgagaaa atctttgtca agatcagcaa cactatttct

661 gagcgggtca tgaatcactg gcaggaagac ctgatgtttg gctaccagtt cctgaatggc

721 tgcaaccctg tgttgatccg gcgctgcaca gagctgcccg agaagctccc ggtgaccacg

781 gagatggtag agtgcagcct ggagcggcag ctcagcttgg agcaggaggt ccagcaaggg

841 aacattttca tcgtggactt tgagctgctg gatggcatcg atgccaacaa aacagacccc θl tgcacactcc agttcctggc cgctcccatc tgcttgctgt ataagaacct ggccaacaag 61 attgtcccca ttgccatcca gctcaaccaa atcccgggag atgagaaccc tattttcctc

1021 ccttcggatg caaaatacga ctggcttttg gccaaaatct gggtgcgttc cagtgacttc

1081 cacgtccacc agaccatcac ccaccttctg cgaacacatc tggtgtctga ggtttttggc

1141 attgcaatgt accgccagct gcctgctgtg caccccattt tcaagctgct ggtggcacac

1201 gtgagattca ccattgcaat caacaccaag gcccgtgagc agctcatctg cgagtgtggc

1261 ctctttgaca aggccaacgc cacagggggc ggtgggcacg tgcagatggt gcagagggcc

1321 atgaaggacc tgacctatgc ctccctgtgc tttcccgagg ccatcaaggc ccggggcatg

1381 gagagcaaag aagacatccc ctactacttc taccgggacg acgggctcct ggtgtgggaa

1441 gccatcagga cgttcacggc cgaggtggta gacatctact acgagggcga ccaggtggtg

1501 gaggaggacc cggagctgca ggacttcgtg aacgatgtct acgtgtacgg catgcggggc

1561 cgcaagtcct caggcttccc caagtcggtc aagagccggg agcagctgtc ggagtacctg

1621 accgtggtga tcttcaccgc ctccgcccag cacgccgcgg tcaacttcgg ccagtacgac

1681 tggtgctcct ggatccccaa tgcgccccca accatgcgag ccccgccacc gactgccaag

1741 ggcgtggtga ccattgagca gatcgtggac acgctgcccg accgcggccg ctcctgctgg

1801 catctgggtg cagtgtgggc gctgagccag ttccaggaaa acgagctgtt cctgggcatg

1861 tacccagaag agcattttat cgagaagcct gtgaaggaag ccatggcccg attccgcaag

1921 aacctcgagg ccattgtcag cgtgattgct gagcgcaaca agaagaagca gctgccatat

1981 tactacttgt ccccagaccg gattccgaac agtgtggcca tc

(2) INFORMATION FOR SEQ ID NO: 4: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2500 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4: 1 gggcccggcg ctcgctgctc ccgcggcccg cgccatgccc tcctacacgg tcaccgtggc

61 cactggcagc cagtggttcg ccggcactga cgactacatc tacctcagcc tcgtgggctc

121 ggcgggctgc agcgagaagc acctgctgga caagcccttc tacaacgact tcgagcgtgg

181 cgcggtggat tcatacgacg tgactgtgga cgaggaactg ggcgagatcc agctggtcag

241 aatcgagaag cgcaagtact ggctgaatga cgactggtac ctgaagtaca tcacgctgaa

301 gacgccccac ggggactaca tcgagttccc ctgctaccgc tggatcaccg gcgatgtcga

361 ggttgtcctg agggatggac gcgcaaagtt ggcccgagat gaccaaattc acattctcaa

421 gcaacaccga ctgaaagaac tggaaacacg gcaaaaacaa tatcgatgga tggagtggaa

481 ccctggcttc cccttgagca tcgatgccaa atgccacaag gatttacccc gtgatatcca

541 gtttgatagt gaaaaaggag tggactttgt tctgaattac tccaaagcga tggagaacct

601 gttcatcaac cgcttcatgc acatgttcca gtcttcttgg aatgacttcg ccgactttga

661 gaaaatcttt gtcaagatca gcaacactat ttctgagcgg gtcatgaatc actggcagga

721 agacctgatg tttggctacc agttcctgaa tggctgcaac cctgtgttga tccggcgctg

781 cacagagctg cccgagaagc tcccggtgac cacggagatg gtagagtgca gcctggagcg

841 gcagctcagc ttggagcagg aggtccagca agggaacatt ttcatcgtgg actttgagct

901 gctggatggc atcgatgcca acaaaacaga cccctgcaca ctccagttcc tggccgctcc

961 catctgcttg ctgtataaga acctggccaa caagattgtc cccattgcca tccagctcaa

1021 ccaaatcccg ggagatgaga accctatttt cctcccttcg gatgcaaaat acgactggct

1081 tttggccaaa atctgggtgc gttccagtga cttccacgtc caccagacca tcacccacct

1141 tctgcgaaca catctggtgt ctgaggtttt tggcattgca atgtaccgcc agctgcctgc

1201 tgtgcacccc attttcaagc tgctggtggc acacgtgaga ttcaccattg caatcaacac EPI-109 1089

1261 caaggcccgt gagcagctca tctgcgagtg tggcctcttt gacaaggcca acgccacagg 1321 gggcggtggg cacgtgcaga tggtgcagag ggccatgaag gacctgacet atgcctccct 1381 gtgctttccc gaggccatca aggcccgggg catggagagc aaagaagaca tcccctacta 1441 cttctaccgg gacgacgggc tcctggtgtg ggaagccatc aggacgttca cggccgaggt 1501 ggtagacatc tactacgagg gcgaccaggt ggtggaggag gacccggagc tgcaggactt 1561 cgtgaacgat gtctacgtgt acggcatgcg gggccgcaag tcctcaggct tccccaagtc 1621 ggtcaagagc cgggagcagc tgtcggagta cctgaccgtg gtgatcttca ccgcctccgc 1681 ccagcacgcc gcggtcaact tcggccagta cgactggtgc tcctggatcc ccaatgcgcc 1741 cccaaccatg cgagccccgc caccgactgc caagggcgtg gtgaccattg agcagatcgt 1801 ggacacgctg cccgaccgcg gccgctcctg ctggcatctg ggtgcagtgt gggcgctgag 1861 ccagttccag gaaaacgagc tgttcctggg catgtaccca gaagagcatt ttatcgagaa 1921 gcctgtgaag gaagccatgg cccgattccg caagaacctc gaggccattg tcagcgtgat 1981 tgctgagcgc aacaagaaga agcagctgcc atattactac ttgtccccag accggattcc 2041 gaacagtgtg gccatctgag cacactgcca gtctcactgt gggaaggcca gctgccccag 2101 ccagatggac tccagcctgc ctggcaggtg tctggccagg cctcttggca gtcacatctc 2161 ttcctccgag gccagtacct ttccatttat tctttgatct tcagggaact gcatagattg 2221 atcaaagtgt aaacaccata gggacccatt ctacacagag caggactgca cagcgtcctg 2281 tccacaccca gctcagcatt tccacaccaa gcagcaacag caaatcacga ccactgatag 2341 atgtctattc ttgttggaga catgggatga ttattttctg ttctatttgt gcttagtcca 2401 attccttgca catagtaggt acccaattca attactattg aatgaattaa gaattggttg 2461 ccataaaaat aaatcagttc atttaaaaaa aaaaaaaaaa

(2) INFORMATION FOR SEQ ID NO:5: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2484 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:5:

1 gggcccggcg ctcgctgctc ccgcggcccg cgccatgccc tcctacacgg tcaccgtggc

61 cactggcagc cagtggttcg ccggcactga cgactacatc tacctcagcc tcgtgggctc

121 ggcgggctgc agcgagaagc acctgctgga caagcccttc tacaacgact tcgagcgtgg

181 cgcggtggat tcatacgacg tgactgtgga cgaggaactg ggcgagatcc agctggtcag

241 aatcgagaag cgcaagtact ggctgaatga cgactggtac ctgaagtaca tcacgctgaa

301 gacgccccac ggggactaca tcgagttccc ctgctaccgc tggatcaccg gcgatgtcga

361 ggttgtcctg agggatggac gcgcaaagtt ggcccgagat gaccaaattc acattctcaa

421 gcaacaccga cgtaaagaac tggaaacacg gcaaaaacaa tatcgatgga tggagtggaa

481 ccctggcttc cccttgagca tcgatgccaa atgccacaag gatttacccc gtgatatcca

541 gtttgatagt gaaaaaggag tggactttgt tctgaattac tccaaagcga tggagaacct

601 gttcatcaac cgcttcatgc acatgttcca gtcttcttgg aatgacttcg ccgactttga

661 gaaaatcttt gtcaagatca gcaacactat ttctgagcgg gtcatgaatc actggcagga

721 agacctgatg tttggctacc agttcctgaa tggctgcaac cctgtgttga tccggcgctg

781 cacagagctg cccgagaagc tcccggtgac cacggagatg gtagagtgca gcctggagcg

841 gcagctcagc ttggagcagg aggtccagca agggaacatt ttcatcgtgg actttgagct

901 gctggatggc atcgatgcca acaaaacaga cccctgcaca ctccagttcc tggccgctcc

961 catctgcttg ctgtataaga acctggccaa caagattgtc cccattgcca tccagctcaa

1021 ccaaatcccg ggagatgaga accctatttt cctcccttcg gatgcaaaat acgactggct

1081 tttggccaaa atctgggtgc gttccagtga cttccacgtc caccagacca tcacccacct

1141 tctgcgaaca catctggtgt ctgaggtttt tggcattgca atgtaccgcc agctgcctgc

1201 tgtgcacccc attttcaagc tgctggtggc acacgtgaga ttcaccattg caatcaacac

1261 caaggcccgt gagcagctca tctgcgagtg tggcctcttt gacaaggcca acgccacagg

1321 gggcggtggg cacgtgcaga tggtgcagag ggccatgaag gacctgacet atgcctccct

1381 gtgctttccc gaggccatca aggcccgggg catggagagc aaagaagaca tcccctacta

1441 cttctaccgg gacgacgggc tcctggtgtg ggaagccatc aggacgttca cggccgaggt

1501 ggtagacatc tactacgagg gcgaccaggt ggtggaggag gacccggagc tgcaggactt

1561 cgtgaacgat gtctacgtgt acggcatgcg gggccgcaag tcctcaggct tccccaagtc

1621 ggtcaagagc cgggagcagc tgtcggagta cctgaccgtg gtgatcttca ccgcctccgc

1681 ccagcacgcc gcggtcaact tcggccagta cgactggtgc tcctggatcc ccaatgcgcc

1741 cccaaccatg cgagccccgc caccgactgc caagggcgtg gtgaccattg agcagatcgt

1801 ggacacgctg cccgaccgcg gccgctcctg ctggcatctg ggtgcagtgt gggcgctgag

1861 ccagttccag gaaaacgagc tgttcctggg catgtaccca gaagagcatt ttatcgagaa

1921 gcctgtgaag gaagccatgg cccgattccg caagaacctc gaggccattg tcagcgtgat

1981 tgctgagcgc aacaagaaga agcagctgcc atattactac ttgtccccag accggattcc

2041 gaacagtgtg gccatctgag cacactgcca gtctcactgt gggaaggcca gctgccccag

2101 ccagatggac tccagcctgc ctggcaggtg tctggccagg cctcttggca gtcacatctc

2161 ttcctccgag gccagtacct ttccatttat tctttgatct tcagggaact gcatagattg

2221 atcaaagtgt aaacaccata gggacccatt ctacacagag caggactgca cagcgtcctg

2281 tccacaccca gctcagcatt tccacaccaa gcagcaacag caaatcacga ccactgatag

2341 atgtctattc ttgttggaga catgggatga ttattttctg ttctatttgt gcttagtcca EPI-109 1090

2401 attccttgca catagtaggt acccaattca attactattg aatgaattaa gaattggttg 2461 ccataaaaat aaatcagttc attt

(2) INFORMATION FOR SEQ ID NO: 6: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2497 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 6: 1 gggcgccgag gctccccgcc gctcgctgct ccccggcccg cgccatgccc tcctacacgg

61 tcaccgtggc cactggcagc cagtggttcg ccggcactga cgactacatc tacctcagcc

121 tcgtgggctc ggcgggctgc agcgagaagc acctgctgga caagcccttc tacaacgact

181 tcgagcgtgg cgcggtggat tcatacgacg tgactgtgga cgaggaactg ggcgagatcc

241 agctggtcag aatcgagaag cgcaagtact ggctgaatga cgactggtac ctgaagtaca

301 tcacgctgaa gacgccccac ggggactaca tcgagttccc ctgctaccgc tggatcaccg

361 gcgatgtcga ggttgtcctg agggatggac gcgcaaagtt ggcccgagat gaccaaattc

421 acattctcaa gcaacaccga cgtaaagaac tggaaacacg gcaaaaacaa tatcgatgga

481 tggagtggaa ccctggcttc cccttgagca tcgatgccaa atgccacaag gatttacccc

541 gtgatatcca gtttgatagt gaaaaaggag tggactttgt tctgaattac tccaaagcga

601 tggagaacct gttcatcaac cgcttcatgc acatgttcca gtcttcttgg aatgacttcg

661 ccgactttga gaaaatcttt gtcaagatca gcaacactat ttctgagcgg gtcatgaatc

721 actggcagga agacctgatg tttggctacc agttcctgaa tggctgcaac cctgtgttga

781 tccggcgctg cacagagctg cccgagaagc tcccggtgac cacggagatg gtagagtgca

841 gcctggagcg gcagctcagc ttggagcagg aggtccagca agggaacatt ttcatcgtgg

901 actttgagct gctggatggc atcgatgcca acaaaacaga cccctgcaca ctccagttcc

961 tggccgctcc catctgcttg ctgtataaga acctggccaa caagattgtc cccattgcca

1021 tccagctcaa ccaaatcccg ggagatgaga accctatttt cctcccttcg gatgcaaaat

1081 acgactggct tttggccaaa atctgggtgc gttccagtga cttccacgtc caccagacca

1141 tcacccacct tctgcgaaca catctggtgt ctgaggtttt tggcattgca atgtaccgcc

1201 agctgcctgc tgtgcacccc attttcaagc tgctggtggc acacgtgaga ttcaccattg

1261 caatcaacac caaggcccgt gagcagctca tctgcgagtg tggcctcttt gacaaggcca

1321 acgccacagg gggcggtggg cacgtgcaga tggtgcagag ggccatgaag gacctgacet

1381 atgcctccct gtgctttccc gaggccatca aggcccgggg catggagagc aaagaagaca

1441 tcccctacta cttctaccgg gacgacgggc tcctggtgtg ggaagccatc aggacgttca

1501 cggccgaggt ggtagacatc tactacgagg gcgaccaggt ggtggaggag gacccggagc

1561 tgcaggactt cgtgaacgat gtctacgtgt acggcatgcg gggccgcaag tcctcaggct

1621 tccccaagtc ggtcaagagc cgggagcagc tgtcggagta cctgaccgtg gtgatcttca

1681 ccgcctccgc ccagcacgcc gcggtcaact tcggccagta cgactggtgc tcctggatcc

1741 ccaatgcgcc cccaaccatg cgagccccgc caccgactgc caagggcgtg gtgaccattg

1801 agcagatcgt ggacacgctg cccgaccgcg gccgctcctg ctggcatctg ggtgcagtgt

1861 gggcgctgag ccagttccag gaaaacgagc tgttcctggg catgtaccca gaagagcatt

1921 ttatcgagaa gcctgtgaag gaagccatgg cccgattccg caagaacctc gaggccattg

1981 tcagcgtgat tgctgagcgc aacaagaaga agcagctgcc atattactac ttgtccccag

2041 accggattcc gaacagtgtg gccatctgag cacactgcca gtctcactgt gggaaggcca

2101 gctgccccag ccagatggac tccagcctgc ctggcaggct gtctggccag gcctcttggc

2161 agtcacatct cttcctccga ggccagtacc tttccattta ttctttgatc ttcagggaac

2221 tgcatagatt gtatcaaagt gtaaacacca tagggaccca ttctacacag agcaggactg

2281 cacaggcgtc ctgtccacac ccagctcagc atttccacac caagcagcaa cagcaaatca

2341 cgaccactga tagatgtcta ttcttgttgg agacatggga tgattatttt ctgttctatt

2401 tgtgcttagt ccaattcctt gcacatagta ggtacccaat tcaattacta ttgaatgaat

2461 taagaattgg ttgccataaa aataaatcag ttcattt

(2) INFORMATION FOR SEQ ID NO: 7: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10151 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 7:

1 cagctgtccc tccccactgc catttattcc ttccttcatt caaaccttat gtggctgcta 61 cttaccgtgt gttaagtgtt cacttttttt cttggaattc aaaaaaagaa ggacagtatt 121 tggggcacag atcttttggt gttctataca tttttttaaa gtttcatttt acatttgtgt 181 gtgcgtgtgt gtgtgtgtgt gagacagtct tgctctgttg cccaggctgg agtgcagtgg 241 cataatcatt ggctcactgt agcctcaaag tcctgggccc aagcgatctt cccacctcag 301 ccacccaaaa tgctggggtt acaggtttat gccactctgt ctgacctgaa agttttgggt 361 ttactttccc ttctttctct ttgctgaagt cagagatgat ggcagcttcc agattctctg 421 gtgcctgtgc tgggctcgtg ctggtcatgg tcttgggtcc aggattcatt ctggagactc 481 tcagggaagt ttcccatgac aaggaaatgt aggagagtgt gctggctttg cgtgctcctc EPI-109 1091

541 tgccaagccc tgcttctcct ggtgggacac actgaaccac agccagggca ttttggtggt

601 tagttaaaaa aaaaaaaaaa aaaaaaaagg aagaagaagg cactgtgtaa ttgtgccggg

661 gatcttcaga aattgtaatg atgaaagagt gcaagctctc acttcccctt cctgtacagg

721 gcaggttgtg cagctggagg cagagcagtc ctctctgggg agcctgaagc aaacatggat

781 caagaaactg taggcaatgt tgtcctgttg gccatcgtca ccctcatcag cgtggtccag

841 aatggtaagg aaagcccttc actcagggaa gaacagaagg ggagattttc tttgatggtt

901 gtttggaagt caggcttaaa caattgtgtc tgtgtgtgcg catgcacaaa cacttttacc

961 ttatctttat tttcttcttt ttatttgaat gtatagggtt gtgtgtattt ctgtgtaaat

1021 ttggggtttt cctcctctta gtctttcact tttgtggtga ttaccagtcc catttttaga

1081 gccagggctg caacttgaag gttttgct

1 tgcgttttgg gggttcctgg agtatcaatc atggatcaag aaactgtagg caatgttgtc

61 ctgttggcca tcgtcaccct catcagcgtg gtccagaatg gattctttgc ccataaagtg

121 gagcacgaaa gcaggaccca gaatgggagg agcttccaga ggaccggaac acttgccttt

181 gagcgggtct acactgccaa ccagaactgt gtagatgcgt accccacttt cctcgctgtg

241 ctctggtctg cggggctact ttgcagccaa gttcctgctg cgtttgctgg actgatgtac

301 ttgtttgtgc ggcaaaagta ctttgtcggt tacctaggag agagaacgca gagcacccct

361 ggctacatat ttgggaaacg catcatactc ttcctgttcc tcatgtccgt tgctggcata

421 ttcaactatt acctcatctt ctttttcgga agtgactttg aaaactacat aaagacgatc

481 tccaccacca tctcccctct acttctcatt tcctaactct ctgctgaata tggggttggt 1 atgccctcct acacggtcac cgtggccact ggcagccagt ggttcgccgg cactgacgac

61 tacatctacc tcagcctcgt gggctcggcg ggctgcagcg agaagcacct gctggacaag

121 cccttctaca acgacttcga gcgtggcgcg gtggattcat acgacgtgac tgtggacgag

181 gaactgggcg agatccagct ggtcagaatc gagaagcgca agtactggct gaatgacgac

241 tggtacctga agtacatcac gctgaagacg ccccacgggg actacatcga gttcccctgc

301 taccgctgga tcaccggcga tgtcgaggtt gtcctgaggg atggacgcgc aaagttggcc

361 cgagatgacc aaattcacat tctcaagcaa caccgacgta aagaactgga aacacggcaa

421 aaacaatatc gatggatgga gtggaaccct ggcttcccct tgagcatcga tgccaaatgc

481 cacaaggatt taccccgtga tatccagttt gatagtgaaa aaggagtgga ctttgttctg

541 aattactcca aagcgatgga gaacctgttc atcaaccgct tcatgcacat gttccagtct

601 tcttggaatg acttcgccga ctttgagaaa atctttgtca agatcagcaa cactatttct

661 gagcgggtca tgaatcactg gcaggaagac ctgatgtttg gctaccagtt cctgaatggc

721 tgcaaccctg tgttgatccg gcgctgcaca gagctgcccg agaagctccc ggtgaccacg

781 gagatggtag agtgcagcct ggagcggcag ctcagcttgg agcaggaggt ccagcaaggg

841 aacattttca tcgtggactt tgagctgctg gatggcatcg atgccaacaa aacagacccc

901 tgcacactcc agttcctggc cgctcccatc tgcttgctgt ataagaacct ggccaacaag

961 attgtcccca ttgccatcca gctcaaccaa atcccgggag atgagaaccc tattttcctc

1021 ccttcggatg caaaatacga ctggcttttg gccaaaatct gggtgcgttc cagtgacttc

1081 cacgtccacc agaccatcac ccaccttctg cgaacacatc tggtgtctga ggtttttggc

1141 attgcaatgt accgccagct gcctgctgtg caccccattt tcaagctgct ggtggcacac

1201 gtgagattca ccattgcaat caacaccaag gcccgtgagc agctcatctg cgagtgtggc

1261 ctctttgaca aggccaacgc cacagggggc ggtgggcacg tgcagatggt gcagagggcc

1321 atgaaggacc tgacctatgc ctccctgtgc tttcccgagg ccatcaaggc ccggggcatg

1381 gagagcaaag aagacatccc ctactacttc taccgggacg acgggctcct ggtgtgggaa

1441 gccatcagga cgttcacggc cgaggtggta gacatctact acgagggcga ccaggtggtg

1501 gaggaggacc cggagctgca ggacttcgtg aacgatgtct acgtgtacgg catgcggggc

1561 cgcaagtcct caggcttccc caagtcggtc aagagccggg agcagctgtc ggagtacctg

1621 accgtggtga tcttcaccgc ctccgcccag cacgccgcgg tcaacttcgg ccagtacgac

1681 tggtgctcct ggatccccaa tgcgccccca accatgcgag ccccgccacc gactgccaag

1741 ggcgtggtga ccattgagca gatcgtggac acgctgcccg accgcggccg ctcctgctgg

1801 catctgggtg cagtgtgggc gctgagccag ttccaggaaa acgagctgtt cctgggcatg

1861 tacccagaag agcattttat cgagaagcct gtgaaggaag ccatggcccg attccgcaag

1921 aacctcgagg ccattgtcag cgtgattgct gagcgcaaca agaagaagca gctgccatat

1981 tactacttgt ccccagaccg gattccgaac agtgtggcca tc

1 gggcccggcg ctcgctgctc ccgcggcccg cgccatgccc tcctacacgg tcaccgtggc

61 cactggcagc cagtggttcg ccggcactga cgactacatc tacctcagcc tcgtgggctc

121 ggcgggctgc agcgagaagc acctgctgga caagcccttc tacaacgact tcgagcgtgg

181 cgcggtggat tcatacgacg tgactgtgga cgaggaactg ggcgagatcc agctggtcag

241 aatcgagaag cgcaagtact ggctgaatga cgactggtac ctgaagtaca tcacgctgaa

301 gacgccccac ggggactaca tcgagttccc ctgctaccgc tggatcaccg gcgatgtcga

361 ggttgtcctg agggatggac gcgcaaagtt ggcccgagat gaccaaattc acattctcaa

421 gcaacaccga ctgaaagaac tggaaacacg gcaaaaacaa tatcgatgga tggagtggaa

481 ccctggcttc cccttgagca tcgatgccaa atgccacaag gatttacccc gtgatatcca

541 gtttgatagt gaaaaaggag tggactttgt tctgaattac tccaaagcga tggagaacct

601 gttcatcaac cgcttcatgc acatgttcca gtcttcttgg aatgacttcg ccgactttga

661 gaaaatcttt gtcaagatca gcaacactat ttctgagcgg gtcatgaatc actggcagga

721 agacctgatg tttggctacc agttcctgaa tggctgcaac cctgtgttga tccggcgctg

781 cacagagctg cccgagaagc tcccggtgac cacggagatg gtagagtgca gcctggagcg

841 gcagctcagc ttggagcagg aggtccagca agggaacatt ttcatcgtgg actttgagct EPI-109 1092

901 gctggatggc atcgatgcca acaaaacaga cccctgcaca ctccagttcc tggccgctcc

961 catctgcttg ctgtataaga acctggccaa caagattgtc cccattgcca tccagctcaa

1021 ccaaatcccg ggagatgaga accctatttt cctcccttcg gatgcaaaat acgactggct

1081 tttggccaaa atctgggtgc gttccagtga cttccacgtc caccagacca tcacccacct

1141 tctgcgaaca catctggtgt ctgaggtttt tggcattgca atgtaccgcc agctgcctgc

1201 tgtgcacccc attttcaagc tgctggtggc acacgtgaga ttcaccattg caatcaacac

1261 caaggcccgt gagcagctca tctgcgagtg tggcctcttt gacaaggcca acgccacagg

1321 gggcggtggg cacgtgcaga tggtgcagag ggccatgaag gacctgacet atgcctccct

1381 gtgctttccc gaggccatca aggcccgggg catggagagc aaagaagaca tcccctacta

1441 cttctaccgg gacgacgggc tcctggtgtg ggaagccatc aggacgttca cggccgaggt

1501 ggtagacatc tactacgagg gcgaccaggt ggtggaggag gacccggagc tgcaggactt

1561 cgtgaacgat gtctacgtgt acggcatgcg gggccgcaag tcctcaggct tccccaagtc

1621 ggtcaagagc cgggagcagc tgtcggagta cctgaccgtg gtgatcttca ccgcctccgc

1681 ccagcacgcc gcggtcaact tcggccagta cgactggtgc tcctggatcc ccaatgcgcc

1741 cccaaccatg cgagccccgc caccgactgc caagggcgtg gtgaccattg agcagatcgt

1801 ggacacgctg cccgaccgcg gccgctcctg ctggcatctg ggtgcagtgt gggcgctgag

1861 ccagttccag gaaaacgagc tgttcctggg catgtaccca gaagagcatt ttatcgagaa

1921 gcctgtgaag gaagccatgg cccgattccg caagaacctc gaggccattg tcagcgtgat

1981 tgctgagcgc aacaagaaga agcagctgcc atattactac ttgtccccag accggattcc

2041 gaacagtgtg gccatctgag cacactgcca gtctcactgt gggaaggcca gctgccccag

2101 ccagatggac tccagcctgc ctggcaggtg tctggccagg cctcttggca gtcacatctc

2161 ttcctccgag gccagtacct ttccatttat tctttgatct tcagggaact gcatagattg

2221 atcaaagtgt aaacaccata gggacccatt ctacacagag caggactgca cagcgtcctg

2281 tccacaccca gctcagcatt tccacaccaa gcagcaacag caaatcacga ccactgatag

2341 atgtctattc ttgttggaga catgggatga ttattttctg ttctatttgt gcttagtcca

2401 attccttgca catagtaggt acccaattca attactattg aatgaattaa gaattggttg

2461 ccataaaaat aaatcagttc atttaaaaaa aaaaaaaaaa 1 gggcccggcg ctcgctgctc ccgcggcccg cgccatgccc tcctacacgg tcaccgtggc

61 cactggcagc cagtggttcg ccggcactga cgactacatc tacctcagcc tcgtgggctc

121 ggcgggctgc agcgagaagc acctgctgga caagcccttc tacaacgact tcgagcgtgg

181 cgcggtggat tcatacgacg tgactgtgga cgaggaactg ggcgagatcc agctggtcag

241 aatcgagaag cgcaagtact ggctgaatga cgactggtac ctgaagtaca tcacgctgaa

301 gacgccccac ggggactaca tcgagttccc ctgctaccgc tggatcaccg gcgatgtcga

361 ggttgtcctg agggatggac gcgcaaagtt ggcccgagat gaccaaattc acattctcaa

421 gcaacaccga cgtaaagaac tggaaacacg gcaaaaacaa tatcgatgga tggagtggaa

481 ccctggcttc cccttgagca tcgatgccaa atgccacaag gatttacccc gtgatatcca

541 gtttgatagt gaaaaaggag tggactttgt tctgaattac tccaaagcga tggagaacct

601 gttcatcaac cgcttcatgc acatgttcca gtcttcttgg aatgacttcg ccgactttga

661 gaaaatcttt gtcaagatca gcaacactat ttctgagcgg gtcatgaatc actggcagga

721 agacctgatg tttggctacc agttcctgaa tggctgcaac cctgtgttga tccggcgctg

781 cacagagctg cccgagaagc tcccggtgac cacggagatg gtagagtgca gcctggagcg

841 gcagctcagc ttggagcagg aggtccagca agggaacatt ttcatcgtgg actttgagct

901 gctggatggc atcgatgcca acaaaacaga cccctgcaca ctccagttcc tggccgctcc

961 catctgcttg ctgtataaga acctggccaa caagattgtc cccattgcca tccagctcaa

1021 ccaaatcccg ggagatgaga accctatttt cctcccttcg gatgcaaaat acgactggct

1081 tttggccaaa atctgggtgc gttccagtga cttccacgtc caccagacca tcacccacct

1141 tctgcgaaca catctggtgt ctgaggtttt tggcattgca atgtaccgcc agctgcctgc

1201 tgtgcacccc attttcaagc tgctggtggc acacgtgaga ttcaccattg caatcaacac

1261 caaggcccgt gagcagctca tctgcgagtg tggcctcttt gacaaggcca acgccacagg

1321 gggcggtggg cacgtgcaga tggtgcagag ggccatgaag gacctgacet atgcctccct

1381 gtgctttccc gaggccatca aggcccgggg catggagagc aaagaagaca tcccctacta

1441 cttctaccgg gacgacgggc tcctggtgtg ggaagccatc aggacgttca cggccgaggt

1501 ggtagacatc tactacgagg gcgaccaggt ggtggaggag gacccggagc tgcaggactt

1561 cgtgaacgat gtctacgtgt acggcatgcg gggccgcaag tcctcaggct tccccaagtc

1621 ggtcaagagc cgggagcagc tgtcggagta cctgaccgtg gtgatcttca ccgcctccgc

1681 ccagcacgcc gcggtcaact tcggccagta cgactggtgc tcctggatcc ccaatgcgcc

1741 cccaaccatg cgagccccgc caccgactgc caagggcgtg gtgaccattg agcagatcgt

1801 ggacacgctg cccgaccgcg gccgctcctg ctggcatctg ggtgcagtgt gggcgctgag

1861 ccagttccag gaaaacgagc tgttcctggg catgtaccca gaagagcatt ttatcgagaa

1921 gcctgtgaag gaagccatgg cccgattccg caagaacctc gaggccattg tcagcgtgat

1981 tgctgagcgc aacaagaaga agcagctgcc atattactac ttgtccccag accggattcc

2041 gaacagtgtg gccatctgag cacactgcca gtctcactgt gggaaggcca gctgccccag

2101 ccagatggac tccagcctgc ctggcaggtg tctggccagg cctcttggca gtcacatctc

2161 ttcctccgag gccagtacct ttccatttat tctttgatct tcagggaact gcatagattg

2221 atcaaagtgt aaacaccata gggacccatt ctacacagag caggactgca cagcgtcctg

2281 tccacaccca gctcagcatt tccacaccaa gcagcaacag caaatcacga ccactgatag

2341 atgtctattc ttgttggaga catgggatga ttattttctg ttctatttgt gcttagtcca

2401 attccttgca catagtaggt acccaattca attactattg aatgaattaa gaattggttg EPI-109 1093

2461 ccataaaaat aaatcagttc attt 1 gggcgccgag gctccccgcc gctcgctgct ccccggcccg cgccatgccc tcctacacgg

61 tcaccgtggc cactggcagc cagtggttcg ccggcactga cgactacatc tacctcagcc

121 tcgtgggctc ggcgggctgc agcgagaagc acctgctgga caagcccttc tacaacgact

181 tcgagcgtgg cgcggtggat tcatacgacg tgactgtgga cgaggaactg ggcgagatcc

241 agctggtcag aatcgagaag cgcaagtact ggctgaatga cgactggtac ctgaagtaca

301 tcacgctgaa gacgccccac ggggactaca tcgagttccc ctgctaccgc tggatcaccg

361 gcgatgtcga ggttgtcctg agggatggac gcgcaaagtt ggcccgagat gaccaaattc

421 acattctcaa gcaacaccga cgtaaagaac tggaaacacg gcaaaaacaa tatcgatgga

481 tggagtggaa ccctggcttc cccttgagca tcgatgccaa atgccacaag gatttacccc

541 gtgatatcca gtttgatagt gaaaaaggag tggactttgt tctgaattac tccaaagcga

601 tggagaacct gttcatcaac cgcttcatgc acatgttcca gtcttcttgg aatgacttcg

661 ccgactttga gaaaatcttt gtcaagatca gcaacactat ttctgagcgg gtcatgaatc

721 actggcagga agacctgatg tttggctacc agttcctgaa tggctgcaac cctgtgttga

781 tccggcgctg cacagagctg cccgagaagc tcccggtgac cacggagatg gtagagtgca

841 gcctggagcg gcagctcagc ttggagcagg aggtccagca agggaacatt ttcatcgtgg

901 actttgagct gctggatggc atcgatgcca acaaaacaga cccctgcaca ctccagttcc

961 tggccgctcc catctgcttg ctgtataaga acctggccaa caagattgtc cccattgcca

1021 tccagctcaa ccaaatcccg ggagatgaga accctatttt cctcccttcg gatgcaaaat

1081 acgactggct tttggccaaa atctgggtgc gttccagtga cttccacgtc caccagacca

1141 tcacccacct tctgcgaaca catctggtgt ctgaggtttt tggcattgca atgtaccgcc

1201 agctgcctgc tgtgcacccc attttcaagc tgctggtggc acacgtgaga ttcaccattg

1261 caatcaacac caaggcccgt gagcagctca tctgcgagtg tggcctcttt gacaaggcca

1321 acgccacagg gggcggtggg cacgtgcaga tggtgcagag ggccatgaag gacctgacet

1381 atgcctccct gtgctttccc gaggccatca aggcccgggg catggagagc aaagaagaca

1441 tcccctacta cttctaccgg gacgacgggc tcctggtgtg ggaagccatc aggacgttca

1501 cggccgaggt ggtagacatc tactacgagg gcgaccaggt ggtggaggag gacccggagc

1561 tgcaggactt cgtgaacgat gtctacgtgt acggcatgcg gggccgcaag tcctcaggct

1621 tccccaagtc ggtcaagagc cgggagcagc tgtcggagta cctgaccgtg gtgatcttca

1681 ccgcctccgc ccagcacgcc gcggtcaact tcggccagta cgactggtgc tcctggatcc

1741 ccaatgcgcc cccaaccatg cgagccccgc caccgactgc caagggcgtg gtgaccattg

1801 agcagatcgt ggacacgctg cccgaccgcg gccgctcctg ctggcatctg ggtgcagtgt

1861 gggcgctgag ccagttccag gaaaacgagc tgttcctggg catgtaccca gaagagcatt

1921 ttatcgagaa gcctgtgaag gaagccatgg cccgattccg caagaacctc gaggccattg

1981 tcagcgtgat tgctgagcgc aacaagaaga agcagctgcc atattactac ttgtccccag

2041 accggattcc gaacagtgtg gccatctgag cacactgcca gtctcactgt gggaaggcca

2101 gctgccccag ccagatggac tccagcctgc ctggcaggct gtctggccag gcctcttggc

2161 agtcacatct cttcctccga ggccagtacc tttccattta ttctttgatc ttcagggaac

2221 tgcatagatt gtatcaaagt gtaaacacca tagggaccca ttctacacag agcaggactg

2281 cacaggcgtc ctgtccacac ccagctcagc atttccacac caagcagcaa cagcaaatca

2341 cgaccactga tagatgtcta ttcttgttgg agacatggga tgattatttt ctgttctatt

2401 tgtgcttagt ccaattcctt gcacatagta ggtacccaat tcaattacta ttgaatgaat

2461 taagaattgg ttgccataaa aataaatcag ttcattt

(2) INFORMATION FOR SEQ ID NO: 8: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2383 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 8: 1 ggcacgaggc tggctgagcc atgatgctgc tgccagaacc cctgcagagg gcctggtttc

61 aggagactca gagtcctctg tgaaaaagcc cttggagagg cgccccagca gggctgcact

121 tggctcctgt gaggaagggg ctcagggtct gggcccctcc gcctgggccg ggctgggagc

181 caggcgggcg gctgggctgc agcaatggac cgtgagctgg cccagcccgc gtccgtgctg

241 agcctgcctg tcgtctgtgg ccatgccatc atgggctcct cggtgtacat cacggtggag

301 ctggccattg ctgtgctggc catcctgggc aatgtgctgg tgtgctgggc cgtgtggctc

361 aacagcaacc tgcagaacgt caccaactac tttgtggtgt cactggcggc ggccgacatc

421 gcagtgggtg tgctcgccat cccctttgcc atcaccatca gcaccgggtt ctgcgctgcc

481 tgccacggct gcctcttcat tgcctgcttc gtcctggtcc tcacgcagag ctccatcttc

541 agtctcctgg ccatcgccat tgaccgctac attgccatcc gcatcccgct ccggtacaat

601 ggcttggtga ccggcacgag ggctaagggc atcattgcca tctgctgggt gctgtcgttt

661 gccatcggcc tgactcccat gctaggttgg aacaactgcg gtcagccaaa ggagggcaag

721 aaccactccc agggctgcgg ggagggccaa gtggcctgtc tctttgagga tgtggtcccc

781 atgaactaca tggtgtactt caacttcttt gcctgtgtgc tggtgcccct gctgctcatg

841 ctgggtgtct atttgcggat cttcctggcg gcgcgacgac agctgaagca gatggagagc

901 cagcctctgc cgggggagcg ggcacggtcc acactgcaga aggaggtcca tgctgccaag

961 tcactggcca tcattgtggg gctctttgcc ctctgctggc tgcccctaca catcatcaac

1021 tgcttcactt tcttctgccc cgactgcagc cacgcccctc tctggctcat gtacctggcc EPI-109 1094

1081 atcgtcctct cccacaccaa ttcggttgtg aatcccttca tctacgccta ccgtatccgc 1141 gagttccgcc agaccttccg caagatcatt cgcagccacg tcctgaggca gcaagaacct 1201 ttcaaggcag ctggcaccag tgcccgggtc ttggcagctc atggcagtga cggagagcag 1261 gtcagcctcc gtctcaacgg ccacccgcca ggagtgtggg ccaacggcag tgctccccac 1321 cctgagcgga ggcccaatgg ctatgccctg gggctggtga gtggagggag tgcccaagag 1381 tcccagggga acacgggcct cccagacgtg gagctcctta gccatgagct caagggagtg 1441 tgcccagagc cccctggcct agatgacccc ctggcccagg atggagcagg agtgtcctga 1501 tgattcatgg agtttgcccc ttcctaaggg aaggagatct ttatctttct ggttggcttg 1561 accagtcacg ttgggagaag agagagagtg ccaggagacc ctgagggcag ccggttccta 1621 ctttggactg agagaaggga gccccaggct ggagcagcat gaggcccagc aagaagggct 1681 tgggttctga ggaagcagat gtttcatgct gtgaggcctt gcaccaggtg ggggccacag 1741 caccagcagc atctttgctg ggcagggccc agccctccac tgcagaagca tctggaagca 1801 ccaccttgtc tccacagagc agcttgggca cagcagactg gcctggccct gagactgggg 1861 agtggctcca acagcctcct gccacccaca caccactctc cctagactct cctagggttc 1921 aggagctgct gggcccagag gtgacatttg acttttttcc aggaaaaatg taagtgtgag 1981 gaaacccttt ttattttatt acctttcact ctctggctgc tgggtctgcc gtcggtcctg 2041 ctgctaacct ggcaccagag cctctgccgg ggagcctcag gcagtcctct cctgctgtca 2101 cagctgccat ccacttctca gtcccagggc catctcttgg agtgacaaag ctgggatcaa 2161 ggacagggag ttgtaacaga gcagtgccag agcatgggcc caggtcccag gggagaggtt 2221 ggggctggca ggccactgg.c atgtgctgag tagcgcagag ctacccagtg agaggccttg 2281 tctaactgcc tttccttcta aagggaatgt ttttttctga gataaaataa aaacgagcca 2341 catcgtgttt taagcttgtc caaatgaaaa aaaaaaaaaa aaa

(2) INFORMATION FOR SEQ ID NO: 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2988 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 9: 1 catcaccttt ttttaagtag taagaataaa gccactgtat gattctctta atagctatac

61 attaatcctg tttttagtgc tgactgggcc agccttccgg gaactggagt ctgtctcttt

121 cagtgctttt ttgttttttg ttggtttttt cgagacgggg tcgatcacgg ctcaccacag

181 ccttaacctc cagggctcca gcaatcctcc cacctcagcc tcctgagtag ctgggaccac

241 aggtgtgtgc caccatctcc agcagtttgt ttatttattt tttctttttt tttttttggt

301 agaaatgggc ttttcgccca tgttgcccaa gctggtcttg cacttctggg ctgaagcaat

361 cctctcgcct tggcctccca gagccttggg attacagaat catgggtgag agctggcatg

421 gcccctagag gtcatttggg gtccagctgc ctcaccgtat caatgaggaa actgaggccc

481 agaaaagaaa agcatttttg cccagagtcc ctcagaaaaa aacagaccac atctgatcct

541 tggccctgag tccagagtgg gaggcaccgt gacaacaatg cgcagagcag ggaatgcagg

601 gagccatgga tagtgctggg gtgcctcagg aaccctgaag ctgggctgag ccatgatgct

661 gctgccagaa cccctgcaga gggcctggtt tcaggagact cagagtcctc tgtgaaaaag

721 cccttggaga gcgccccagc agggctgcac ttggctcctg tgaggaaggg gctcaggggt

781 ctgggcccct ccgcctgggc cgggctggga gccaggcggg cggctgggct gcagcaatgg

841 accgtgagct ggcccagccc gcgtccgtgc tgagcctgcc tgtcgtctgt ggcatgccca

901 tcatgggctc ctcggtgtac atcacggtgg agctggccat tgctgtgctg gccatcctgg

961 gcaatgtgct ggtgtgctgg gccgtgtggc tcaacagcaa cctgcagaac gtcaccaact

1021 actttgtggt gtcactggcg gcggccgaca tcgcagtggg tgtgctcgcc atcccctttg

1081 ccatcaccat cagcaccggg ttctgcgctg cctgccacgg ctgcctcttc attgcctgct

1141 tcgtcctggt cctcacgcag agctccatct tcagtctcct ggccatcgcc attgaccgct

1201 acattgccat ccgcatcccg ctccggtaca atggcttggt gaccggcacg agggctaagg

1261 gcatcattgc catctgctgg gtgctgtcgt ttgccatcgg cctgactccc atgctaggtt

1321 ggaacaactg cggtcagcca aaggagggca agaaccactc ccagggctgc ggggagggcc

1381 aagtggcctg tctctttgag gatgtggtcc ccatgaacta catggtgtac ttcaacttct

1441 ttgcctgtgt gctggtgccc ctgctgctca tgctgggtgt ctatttgcgg atcttcctgg

1501 cggcgcgacg acagctgaag cagatggaga gccagcctct gccgggggag cgggcacggt

1561 ccacactgca gaaggaggtc catgctgcca agtcactggc catcattgtg gggctctttg

1621 ccctctgctg gctgccccta cacatcatca actgcttcac tttcttctgc cccgactgca

1681 gccacgcccc tctctggctc atgtacctgg ccatcgtcct ctcccacacc aattcggttg

1741 tgaatccctt catctacgcc taccgtatcc gcgagttccg ccagaccttc cgcaagatca

1801 ttcgcagcca cgtcctgagg cagcaagaac ctttcaaggc agctggcacc agtgcccggg

1861 tcttggcagc tcatggcagt gacggagagc aggtcagcct ccgtctcaac ggccacccgc

1921 caggagtgtg ggccaacggc agtgctcccc accctgagcg gaggcccaat ggctatgccc

1981 tggggctggt gagtggaggg agtgcccaag agtcccaggg gaacacgggc ctcccagacg

2041 tggagctcct tagccatgag ctcaagggag tgtgcccaga gccccctggc ctagatgacc

2101 ccctggccca ggatggagca ggagtgtcct gatgattcat ggagtttgcc ccttcctaag

2161 ggaaggagat ctttatcttt ctggttggct tgaccagtca cgttgggaga agagagagag

2221 tgccaggaga ccctgagggc agccggttcc tactttggac tgagagaagg gagccccagg

2281 ctggagcagc atgaggccca gcaagaaggg cttgggttct gaggaagcag atgtttcatg EPI-109 1095

2341 ctgtgaggcc ttgcaccagg tgggggccac agcaccagca gcagcatctt tctgggcagg 2401 cccagccctc cactgcagaa gcatctggaa gcaccacctt gtctccacag agcagcttgg 2461 gcacagcaga ctggcctggc cctgagactg gggagtggct ccaacagcct cctgccaccc 2521 acacaccact ctccctagac tctcctaggg ttcaggagct gctgggccca gaggtgacat 2581 ttgacttttt tccaggaaaa atgtaagtgt gaggaaaccc cttttatttt attacctttc 2641 actctctggc tgctgggtct gccgtcggtc ctgctgctaa cctggcagca gagcctctgc 2701 ccggggagcc tcaggcagtc ctctcctgct gtcacagctg ccatccactt ctcagtccca 2761 gggccatctc ttggagtgac aaagctggga tcaaggacag ggagttgtaa cagagcagtg 2821 ccagagcatg ggcccaggtc ccaggggaga ggttggggct ggcaggccac tggcatgtgc 2881 tgagtagcgc agagctaccc agtgagaggc cttgtctaac tgcctttcct tctaaaggga 2941 atgttttttt ctgagataaa ataaaaacga gccacatcgt gttttaag

(2) INFORMATION FOR SEQ ID NO: 10: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2157 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:10: 1 ggcacgagcc cagaaacaaa gacttcacgg acaaagtccc ttggaaccag agagaagccg

61 ggatggaaac tccaaacacc acagaggact atgacacgac cacagagttt gactatgggg

121 atgcaactcc gtgccagaag gtgaacgaga gggcctttgg ggcccaactg ctgccccctc

181 tgtactcctt ggtatttgtc attggcctgg ttggaaacat cctggtggtc ctggtccttg

241 tgcaatacaa gaggctaaaa aacatgacca gcatctacct cctgaacctg gccatttctg

301 acctgctctt cctgttcacg cttcccttct ggatcgacta caagttgaag gatgactggg

361 tttttggtga tgccatgtgt aagatcctct ctgggtttta ttacacaggc ttgtacagcg

421 agatcttttt catcatcctg ctgacgattg acaggtacct ggccatcgtc cacgccgtgt

481 ttgccttgcg ggcacggacc gtcacttttg gtgtcatcac cagcatcatc atttgggccc

541 tggccatctt ggcttccatg ccaggcttat acttttccaa gacccaatgg gaattcactc

601 accacacctg cagccttcac tttcctcacg aaagcctacg agagtggaag ctgtttcagg

661 ctctgaaact gaacctcttt gggctggtat tgcctttgtt ggtcatgatc atctgctaca

721 cagggattat aaagattctg ctaagacgac caaatgagaa gaaatccaaa gctgtccgtt

781 tgatttttgt catcatgatc atcttttttc tcttttggac cccctacaat ttgactatac

841 ttatttctgt tttccaagac ttcctgttca cccatgagtg tgagcagagc agacatttgg

901 acctggctgt gcaagtgacg gaggtgatcg cctacacgca ctgctgtgtc aacccagtga

961 tctacgcctt cgttggtgag aggttccgga aaggttaaccccttggccgg gcagttgttc cacaggcgtg

1021 tggctgtgca cctggttaaa tggctcccct tcctctccgt ggacaggctg gagagggtca

1081 gctccacatc tccctccaca ggggagcatg aactctctgc tgggttctga ctcagaccat

1141 aggaggccaa cccaaaataa gcaggcgtga cctgccaggc acactgagcc agcagcctgg

1201 ctctcccagc caggttctga ctcttggcac agcatggagt cacagccact tgggatagag

1261 agggaatgta atggtggcct ggggcttctg aggcttctgg ggcttcagtc ttttccatga

1321 acttctcccc tggtagaaag aagatgaatg agcaaaacca aatattccag agactgggac

1381 taagtgtacc agagaagggc ttggactcaa gcaagatttc agatttgtga ccattagcat

1441 ttgtcaacaa agtcacccac ttcccactat tgcttgcaca aaccaattaa acccagtagt

1501 ggtgactgtg ggctccattc aaagtgagct cctaagccat gggagacact gatgtatgag

1561 gaatttctgt tcttccatca cctccccccc cccgccaccc tcccactgcc aagaacttgg

1621 aaatagtgat ttccacagtg actccactct gagtcccaga gccaatcagt agccagcatc

1681 tgcctcccct tcactcccac cgcaggattt gggctcttgg aatcctgggg aacatagaac

1741 tcatgacgga agagttgaga cctaacgaga aatagaaatg ggggaactac tgctggcagt

1801 ggaactaaga aagcccttag gaagaatttt tatatccact aaaatcaaac aattcaggga

1861 gtgggctaag cacgggccat atgaataaca tggtgtgctt cttaaaatag ccataaaggg

1921 gagggactca tcatttccat ttacccttct tttctgacta tttttcagaa tctctcttct

1981 tttcaagttg ggtgatatgt tggtagattc taatggcttt attgcagcga ttaataacag

2041 gcaaaaggaa gcagggttgg tttcccttct ttttgttctt catctaagcc ttctggtttt

2101 atgggtcaga gttccgactg ccatcttgga cttgtcagca aaaaaaaaaa aaaaaa

(2) INFORMATION FOR SEQ ID NO: 11: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 949 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 11: 1 agaagctttt gctcctggga ttaggttgat gggcctctaa tgtcaccagt gaaatgggat

61 attagatatt ttccagctag gatacgacag ctcccaataa aaccaaatta ctaagccttt 121 tctgcaagca aggagccgtc tggaacataa ggactttaac cttgggtagg agacaggcaa 181 gcagaagtct tcaattgtgt cacaattttc actgaggact caagtgacct aagaaagtaa 241 ttgtgattgt cagagccttg ttcttccttt tctttctcca gccgcacgct tcacctactc 301 aggagagtgc ctacgcaatc tgacttgaca gcttctagaa agaaattaga gcaacagggg EPI-109 1096

361 tctcagcagg gtggtcttgg gccaaacact gaaagcaggc aggcttaccc tttcctcttc 421 tgcccccttc aactttttcc tgatgttctt acccacatcc ctcaccacac cacacccttt 481 cattcatcct tgtcccagac ttattaagta tatacagata agcaatccag ggaacttgca 541 ttcattagga gaaacccaga aattcaaaag caataatgat ctaatcccag aggagtagaa 601 aacaggaagt gggcagctgc cagctttctt gctttgctgg agtattctgg aatttgatgg 661 gttgagggtt ctggacacaa tgccccaagc cccttccttg ttgtgctggg ttcctatttc 721 tgctctcggc actgacttag cagctgctca agagctcact atgttggctt ggattacact 781 ggtctcaccc acatctccgg cagtttgtgg gcaaacctcc tgagcagcct tgggtgatga 841 aacctttcat ggtagcagga gaatgggact gtgaattctc aatcccctgt ccccacccct 901 tccttcctct ctcagggcct taaagtctag gaggaggaag cacagcagc

(2) INFORMATION FOR SEQ ID NO: 12: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3734 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:12: 1 cttgctttgc tggagtattc tggtaatttg atgggttgag ggttctggac acaatgcccc

61 aagccccttc cttgttgtgc tgggttccta tttctgctct cggcactgac ttagcagctg

121 ctcaagagct cactatgttg gcttggatta cacggtctca cccacatctc cggcagtttg

181 tgggcaaacc tcctgagcag ccttgggtga tgaaaccttt catggtagca ggagaatggg

241 actgtgaatt ctcaatcccc tgtccccacc ccttccttcc tctctcaggg ccttaaagtc

301 taggaggagg aagcacagca gcaactgact gggcagcctt tcaggaaaga tgcagccact

361 cctgcttctg ctggcctttc tcctacccac tggggctgag gcaggtgagt gaccatcccc

421 accctcagag gcctgacctc atcccataga ttcttgagcc aaattgcctt ggtatatcct

481 aattctgtac tgttgagcaa gttatttgaa tttgtgtttc ctcatctata aaatgagaat

541 aatattaata ccgatcttgc agagttgcca tgagagttaa ataagttaga gtatttaaat

601 gtcttggaat tgcccgcaca ctataagtgc tataaaaaca tgctttgtgt aaataatttg

661 gcagcatgtg tcagacccta cctaggaggt aagaatacag caataacagt accatcagct

721 catgtctaga tttttaaaca ccagtcccac gtggtcttga attggactca gagggctctg

781 ggaagctcca tgaggataaa agtataaggg aacttcagga acaatcctgt acttacagca

841 aagcattctc ctcaatacct gaggctgaag ctggccttgc ctggaacaag ggttgttctc

901 cctcttttgg agaggaggag ggaggtgagg cctaggatgg ggaaaagggc tcctttcaag

961 acagcagtgt ttcctgtaga accctggagc cccctcccaa tctgctgccc catagactcc

1021 aagcctcagc accatctcct ccctctcctg caccctctct cctgccgtcc ccatcttcca

1081 gcctttctgg agccaccaat ctggtaccca cattgcaggt tcagcaagca tagagctaag

1141 tgccaaatgc ttccttccag gggagatcat cggaggccgg gagagcaggc cccactcccg

1201 cccctacatg gcgtatcttc agatccagag tccagcaggt cagagcagat gtggagggtt

1261 cctggtgcga gaagactttg tgctgacagc agctcattgc tggggaaggt gaggagctaa

1321 ggaacttcct ggccagccag gaacacagcc ctgcggagct cttcggtgga agagccatct

1381 gaaagaagag ttgtagcaat gaaagggtga aagaaagacc aagtgagtct ttgcgggagg

1441 gaacaggcca gtgtaaatga ggaggaaagg aggataagat caaaaagagc aagaggaaga

1501 gatggaagac acatattggg gctcaaaata taaactcagg ctatttatca acttaatctg

1561 gggaagtaaa cctgaaggca agtaccaccc tgtcatccct agctcagagc tgctgagaaa

1621 gaggatacag ctgagcccca gggccctccc atcccctcga ttctggttag ctgcagtctt

1681 gccctccccg tgctgtctgc ctaccctgca gagctggtgg accatagctc ctgcagccca

1741 gacctacctc ttgcttttgc agcaatataa atgtcaccct gggcgcccac aatatccaga

1801 gacgggaaaa cacccagcaa cacatcactg cgcgcagagc catccgccac cctcaatata

1861 atcagcggac catccagaat gacatcatgt tattgcaggt accacctacc tggccctctg

1921 gctccttcct agtgtgtccg gggacaatgg aggaggaagt gagggcaagg ctccggggtg

1981 gcggggaggg catgggatgt gtactgcacc agcgaccccc gagccttggc tggaggcccc

2041 agctgagcgg gaacgcctac attcttcctc cagctgagca gaagagtcag acggaatcga

2101 aacgtgaacc cagtggctct gcctagagcc caggagggac tgagacccgg gacgctgtgc

2161 actgtggccg gctggggcag ggtcagcatg aggaggggaa cagatacact ccgagaggtg

2221 cagctgagag tgcagaggga taggcagtgc ctccgcatct tcggttccta cgacccccga

2281 aggcagattt gtgtggggga ccggcgggaa cggaaggctg ccttcaaggt aaggcatggg

2341 cattggccaa cacaccccgg gagagagggg cccgtgcaga gccaggcagt gcgaacagat

2401 tccatcccca cagcctcagc ctggcagcca gaccagggtg ggctggggat tgttttcccc

2461 atcaacctgg tctctggggg aataggagga agacccacaa cacatacata ggcaacattc

2521 tcctggagaa gggagaggta ccttgactca gattgggctg gagacagtaa ttaaggcaga

2581 gctgaagtcc agcgaccgaa aagatccaga ggcttggctc ctgtacccca ccgatcttcc

2641 atctcacaca cacccagcaa ttgaaggggc ccacccaccc ctgccttccc tgagagcccg

2701 gagctcaggg aagcaggagc agggaggcct gtctcagtct cccttctcct ctctacctac

2761 agggggattc cggaggcccc ctgctgtgta acaatgtggc ccacggcatc gtctcctatg

2821 gaaagtcgtc aggggttcct ccagaagtct tcaccagggt ctcaagtttc ctgccctgga

2881 taaggacaac aatgagaagc ttcaaactgc tggatcagat ggagaccccc ctgtgactga

2941 ctcttcttct cggggacaca ggccagctcc acagtgttgc cagagcctta ataaacgtcc

3001 acagagtata aataaccaat tcctcatttg ttcattaaac gtcattcagt acttagtttg EPI-109 1097

3061 tttggattgc tacaacaaaa tagcacaaat tgggtggctt ataaataaca aatttatttc

3121 tcacaggtct agaggctaag aagtctaaga tcaagtcact agcagattca gtgtctaatt

3181 agggcccatt ttctggttca cagacaacca tcctctccct gtgtccacat atggcaaaag

3241 gggcaaggga attctctgat gtctctttta caagggacct agtctcattc aaagagctca

3301 gcttttacga cctaatcaca tcccaaaggc cccacctaat gccatcacga cattggggat

3361 taggtctggg aaacataggg aaagagtgtc tctacacaaa aattttaaaa ttagccaggc

3421 atggtggcat gtgtctatag tcccagctac ttgggaggct aaagtggaag gattagttga

3481 acccacgagg ttgaggcttc agtgaaccat gcactccagc ctgagcgaca gagcaagaca

3541 ccattccaag aaagaaaaaa aaaaagactg gcaggccaaa aagacagaac tgaaattcca

3601 aaaaaaaaga cctactttag tgtatgaaaa aggtggcatc tcaaatcact gggaaacaat

3661 ggaatttttg aataaatagc attagaacca acctagatag atatttggag gggatggaag

3721 gtataattgg atcc

(2) INFORMATION FOR SEQ ID NO: 13:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4683 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13: 1 agaagctttt gctcctggga ttaggttgat gggcctctaa tgtcaccagt gaaatgggat

61 attagatatt ttccagctag gatacgacag ctcccaataa aaccaaatta ctaagccttt

121 tctgcaagca aggagccgtc tggaacataa ggactttaac cttgggtagg agacaggcaa

181 gcagaagtct tcaattgtgt cacaattttc actgaggact caagtgacct aagaaagtaa

241 ttgtgattgt cagagccttg ttcttccttt tctttctcca gccgcacgct tcacctactc

301 aggagagtgc ctacgcaatc tgacttgaca gcttctagaa agaaattaga gcaacagggg

361 tctcagcagg gtggtcttgg gccaaacact gaaagcaggc aggcttaccc tttcctcttc

421 tgcccccttc aactttttcc tgatgttctt acccacatcc ctcaccacac cacacccttt

481 cattcatcct tgtcccagac ttattaagta tatacagata agcaatccag ggaacttgca

541 ttcattagga gaaacccaga aattcaaaag caataatgat ctaatcccag aggagtagaa

601 aacaggaagt gggcagctgc cagctttctt gctttgctgg agtattctgg aatttgatgg

661 gttgagggtt ctggacacaa tgccccaagc cccttccttg ttgtgctggg ttcctatttc

721 tgctctcggc actgacttag cagctgctca agagctcact atgttggctt ggattacact

781 ggtctcaccc acatctccgg cagtttgtgg gcaaacctcc tgagcagcct tgggtgatga

841 aacctttcat ggtagcagga gaatgggact gtgaattctc aatcccctgt ccccacccct

901 tccttcctct ctcagggcct taaagtctag gaggaggaag cacagcagc 1 cttgctttgc tggagtattc tggtaatttg atgggttgag ggttctggac acaatgcccc

61 aagccccttc cttgttgtgc tgggttccta tttctgctct cggcactgac ttagcagctg

121 ctcaagagct cactatgttg gcttggatta cacggtctca cccacatctc cggcagtttg

181 tgggcaaacc tcctgagcag ccttgggtga tgaaaccttt catggtagca ggagaatggg

241 actgtgaatt ctcaatcccc tgtccccacc ccttccttcc tctctcaggg ccttaaagtc

301 taggaggagg aagcacagca gcaactgact gggcagcctt tcaggaaaga tgcagccact

361 cctgcttctg ctggcctttc tcctacccac tggggctgag gcaggtgagt gaccatcccc

421 accctcagag gcctgacctc atcccataga ttcttgagcc aaattgcctt ggtatatcct

481 aattctgtac tgttgagcaa gttatttgaa tttgtgtttc ctcatctata aaatgagaat

541 aatattaata ccgatcttgc agagttgcca tgagagttaa ataagttaga gtatttaaat

601 gtcttggaat tgcccgcaca ctataagtgc tataaaaaca tgctttgtgt aaataatttg

661 gcagcatgtg tcagacccta cctaggaggt aagaatacag caataacagt accatcagct

721 catgtctaga tttttaaaca ccagtcccac gtggtcttga attggactca gagggctctg

781 ggaagctcca tgaggataaa agtataaggg aacttcagga acaatcctgt acttacagca

841 aagcattctc ctcaatacct gaggctgaag ctggccttgc ctggaacaag ggttgttctc

901 cctcttttgg agaggaggag ggaggtgagg cctaggatgg ggaaaagggc tcctttcaag

961 acagcagtgt ttcctgtaga accctggagc cccctcccaa tctgctgccc catagactcc

1021 aagcctcagc accatctcct ccctctcctg caccctctct cctgccgtcc ccatcttcca

1081 gcctttctgg agccaccaat ctggtaccca cattgcaggt tcagcaagca tagagctaag

1141 tgccaaatgc ttccttccag gggagatcat cggaggccgg gagagcaggc cccactcccg

1201 cccctacatg gcgtatcttc agatccagag tccagcaggt cagagcagat gtggagggtt

1261 cctggtgcga gaagactttg tgctgacagc agctcattgc tggggaaggt gaggagctaa

1321 ggaacttcct ggccagccag gaacacagcc ctgcggagct cttcggtgga agagccatct

1381 gaaagaagag ttgtagcaat gaaagggtga aagaaagacc aagtgagtct ttgcgggagg

1441 gaacaggcca gtgtaaatga ggaggaaagg aggataagat caaaaagagc aagaggaaga

1501 gatggaagac acatattggg gctcaaaata taaactcagg ctatttatca acttaatctg

1561 gggaagtaaa cctgaaggca agtaccaccc tgtcatccct agctcagagc tgctgagaaa

1621 gaggatacag ctgagcccca gggccctccc atcccctcga ttctggttag ctgcagtctt

1681 gccctccccg tgctgtctgc ctaccctgca gagctggtgg accatagctc ctgcagccca

1741 gacctacctc ttgcttttgc agcaatataa atgtcaccct gggcgcccac aatatccaga

1801 gacgggaaaa cacccagcaa cacatcactg cgcgcagagc catccgccac cctcaatata

1861 atcagcggac catccagaat gacatcatgt tattgcaggt accacctacc tggccctctg

1921 gctccttcct agtgtgtccg gggacaatgg aggaggaagt gagggcaagg ctccggggtg EPI-109 1098

1981 gcggggaggg catgggatgt gtactgcacc agcgaccccc gagccttggc tggaggcccc 2041 agctgagcgg gaacgcctac attcttcctc cagctgagca gaagagtcag acggaatcga 2101 aacgtgaacc cagtggctct gcctagagcc caggagggac tgagacccgg gacgctgtgc 2161 actgtggccg gctggggcag ggtcagcatg aggaggggaa cagatacact ccgagaggtg 2221 cagctgagag tgcagaggga taggcagtgc ctccgcatct tcggttccta cgacccccga 2281 aggcagattt gtgtggggga ccggcgggaa cggaaggctg ccttcaaggt aaggcatggg 2341 cattggccaa cacaccccgg gagagagggg cccgtgcaga gccaggcagt gcgaacagat 2401 tccatcccca cagcctcagc ctggcagcca gaccagggtg ggctggggat tgttttcccc 2461 atcaacctgg tctctggggg aataggagga agacccacaa cacatacata ggcaacattc 2521 tcctggagaa gggagaggta ccttgactca gattgggctg gagacagtaa ttaaggcaga 2581 gctgaagtcc agcgaccgaa aagatccaga ggcttggctc ctgtacccca ccgatcttcc 2641 atctcacaca cacccagcaa ttgaaggggc ccacccaccc ctgccttccc tgagagcccg 2701 gagctcaggg aagcaggagc agggaggcct gtctcagtct cccttctcct ctctacctac 2761 agggggattc cggaggcccc ctgctgtgta acaatgtggc ccacggcatc gtctcctatg 2821 gaaagtcgtc aggggttcct ccagaagtct tcaccagggt ctcaagtttc ctgccctgga 2881 taaggacaac aatgagaagc ttcaaactgc tggatcagat ggagaccccc ctgtgactga 2941 ctcttcttct cggggacaca ggccagctcc acagtgttgc cagagcctta ataaacgtcc 3001 acagagtata aataaccaat tcctcatttg ttcattaaac gtcattcagt acttagtttg 3061 tttggattgc tacaacaaaa tagcacaaat tgggtggctt ataaataaca aatttatttc 3121 tcacaggtct agaggctaag aagtctaaga tcaagtcact agcagattca gtgtctaatt 3181 agggcccatt ttctggttca cagacaacca tcctctccct gtgtccacat atggcaaaag 3241 gggcaaggga attctctgat gtctctttta caagggacct agtctcattc aaagagctca 3301 gcttttacga cctaatcaca tcccaaaggc cccacctaat gccatcacga cattggggat 3361 taggtctggg aaacataggg aaagagtgtc tctacacaaa aattttaaaa ttagccaggc 3421 atggtggcat gtgtctatag tcccagctac ttgggaggct aaagtggaag gattagttga 3481 acccacgagg ttgaggcttc agtgaaccat gcactccagc ctgagcgaca gagcaagaca 3541 ccattccaag aaagaaaaaa aaaaagactg gcaggccaaa aagacagaac tgaaattcca 3601 aaaaaaaaga cctactttag tgtatgaaaa aggtggcatc tcaaatcact gggaaacaat 3661 ggaatttttg aataaatagc attagaacca acctagatag atatttggag gggatggaag 3721 gtataattgg atcc

(2) INFORMATION FOR SEQ ID NO: 14: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2156 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14:

1 ggcacgagcc cagaaacaaa gacttcacgg acaaagtccc ttggaaccag agagaagccg

61 ggatggaaac tccaaacacc acagaggact atgacacgac cacagagttt gactatgggg

121 atgcaactcc gtgccagaag gtgaacgaga gggcctttgg ggcccaactg ctgccccctc

181 tgtactcctt ggtatttgtc attggcctgg ttggaaacat cctggtggtc ctggtccttg

241 tgcaatacaa gaggctaaaa aacatgacca gcatctacct cctgaacctg gccatttctg

301 acctgctctt cctgttcacg cttcccttct ggatcgacta caagttgaag gatgactggg

361 tttttggtga tgccatgtgt aagatcctct ctgggtttta ttacacaggc ttgtacagcg

421 agatcttttt catcatcctg ctgacgattg acaggtacct ggccatcgtc cacgccgtgt

481 ttgccttgcg ggcacggacc gtcacttttg gtgtcatcac cagcatcatc atttgggccc

541 tggccatctt ggcttccatg ccaggcttat acttttccaa gacccaatgg gaattcactc

601 accacacctg cagccttcac tttcctcacg aaagcctacg agagtggaag ctgtttcagg

661 ctctgaaact gaacctcttt gggctggtat tgcctttgtt ggtcatgatc atctgctaca

721 cagggattat aaagattctg ctaagacgac caaatgagaa gaaatccaaa gctgtccgtt

781 tgatttttgt catcatgatc atcttttttc tcttttggac cccctacaat ttgactatac

841 ttatttctgt tttccaagac ttcctgttca cccatgagtg tgagcagagc agacatttgg

901 acctggctgt gcaagtgacg gaggtgatcg cctacacgca ctgctgtgtc aacccagtga

961 tctacgcctt cgttggtgag aggttccgga agtacctgcg gcagttgttc cacaggcgtg

1021 tggctgtgca cctggttaaa tggctcccct tcctctccgt ggacaggctg gagagggtca

1081 gctccacatc tccctccaca ggggagcatg aactctctgc tgggttctga ctcagaccat

1141 aggaggccaa cccaaaataa gcaggcgtga cctgccaggc acactgagcc agcagcctgg

1201 ctctcccagc caggttctga ctcttggcac agcatggagt cacagccact tgggatagag

1261 agggaatgta atggtggcct ggggcttctg aggcttctgg ggcttcagtc ttttccatga

1321 acttctcccc tggtagaaag aagatgaatg agcaaaacca aatattccag agactgggac

1381 taagtgtacc agagaagggc ttggactcaa gcaagatttc agatttgtga ccattagcat

1441 ttgtcaacaa agtcacccac ttcccactat tgcttgcaca aaccaattaa acccagtagt

1501 ggtgactgtg ggctccattc aaagtgagct cctaagccat gggagacact gatgtatgag

1561 gaatttctgt tcttccatca cctccccccc cccgccaccc tcccactgcc aagaacttgg

1621 aaatagtgat ttccacagtg actccactct gagtcccaga gccaatcagt agccagcatc

1681 tgcctcccct tcactcccac cgcaggattt gggctcttgg aatcctgggg aacatagaac

1741 tcatgacgga agagttgaga cctaacgaga aatagaaatg ggggaactac tgctggcagt EPI-109 1099

1801 ggaactaaga aagcccttag gaagaatttt tatatccact aaaatcaaac aattcaggga 1861 gtgggctaag cacgggccat atgaataaca tggtgtgctt cttaaaatag ccataaaggg 1921 gagggactca tcatttccat ttacccttct tttctgacta tttttcagaa tctctcttct 1981 tttcaagttg ggtgatatgt tggtagattc taatggcttt attgcagcga ttaataacag 2041 gcaaaaggaa gcagggttgg tttcccttct ttttgttctt catctaagcc ttctggtttt 2101 atgggtcaga gttccgactg ccatcttgga cttgtcagca aaaaaaaaaa aaaaaa

(2) INFORMATION FOR SEQ ID NO: 15: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2955 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 15: 1 gagagccccc cccccgagac tgaaagtttt ggagattcag gggtcggggg aaagggttca

61 ggaaatggta attgagtttc caagggatag tgttacaagt ggtatgggag gccccctatt

121 tctgatagta atagagaata ttttctttgt tcattatgat agaacccgtg ggataaagag

181 ggaaaataaa tgttgggagt cccccagggg agaggagaga atccaacagg gtgatttgct

241 gatatttgta cgaggaggga aagaattttt caaagacaaa gttggagtga ggagtttttg

301 tagagggaac caggtggggt acaaagagag agacacactg agccggtggg aagggaagaa

361 ttaagagggg tgttccccca cactgtatat taagaaagaa aaacaatggg gacaggacgg

421 cagaagttag agtttcttaa ccaggatgag agggggattt cacggtaact aatgagtgat

481 ttcagacctt attccactat cccagggcaa tcagatatta atcatgtaca agttgaaatc

541 atgcgtgtcc tttgaggtaa gacttacata atcctattta gcataacagg cccccagatc

601 cagaaagggg agggttccgc ccctatcact gaaggggatc agggatatga aagtggctca

661 tggttgacca tcacgtttaa caggaatggg caatcaggag gggtaggtcc aattgtgacc

721 aacagaccaa acttccatta atgcttgcgg ttcttgtggc aaagccagtc tgtgaggttt

781 gatggggatg gacttggtga gcagagagca gggggacaac gaatcccaga agctgagggg

841 aatggggttc caaagagccg ctgctgcctc tgggagcacc catgtcagtt agtttttccg

901 tacgggactc agggttccag attattcgtt tttaaatcct tccattcaca atctttaaga

961 agaagaaaaa aaagaagtct gccgctgacc acaagagctc tatgccctgc ccccatccca

1021 catacacaca tcccacactt caattgctcc aaacattctg ggaacatctc actgccaccc

1081 acctcaccca actcagctt^'c acctgccccc aattccctta aggctgagct cccagggcca

1141 agactcaaga ggctcagagt gagcagagaa aatcctcgca gttaacttgg cttccaggaa

1201 gtggccactg gtgggcgttg tggccattca tgagcaccaa accacacaaa aagaactttg

1261 tccctttctt gtcattttga aagactgtga aactggagcc aattctccat catcacacag

1321 gaagctgagt acttcctact tggtcaggat cttgaaactt gaattcataa aacccagaaa

1381 gccccagaaa caaagacttc acggacaaag tcccttggaa ccagagtaag tgtcacttgt

1441 cttttctgtc ttatctgtta ctgtggaggg cagtgttgtt caaagacatg catgcagcta

1501 ggggctcctc aaaggtaggg ggaattcttt gagtaggctg ggcaaatgtc taagtagccc

1561 atggatgcat ctccaaggca attaatactg tagcaatact gagaatggtg gatttataaa

1621 gctgggtgct cagatgaaat ataggctttt ttgctaaaaa ggaagcttac ttgaaggatt

1681 ggcttttggt tactgattaa gaaagtcagt cagtactaag ggacaaaagg tgttttctgt

1741 ggaaacctat tcaataagaa attacttggc ggggcgcagt ggctcacggc tgtaatccca

1801 gcactttggg agaccgaggc aggtggatca tgaggtcaag agatggagac aatcctggcc

1861 atatggtgaa accctgtctc tactaaaaat aaaaattagc cgggcaggtg gccgcagcct

1921 gttagtccca gctactcaag aggctgaggc aggagaatca ctcgaatccg ggaggtggag

1981 gttgcagtga gctgagattg caccacaaca ctccagcctg gcgacagagc aagagtctgt

2041 ctgaaaaaaa aaaattgctt gccaaattcc cccaagtaaa ggaaaaccaa acatggtgta

2101 tgaagaaatt atagcaagag ggaaatatta gctagaaaaa tcttggcaga tgcaaggatg

2161 atttgatact gaacctatct cttaagaaga ctagaaccaa ggatcctcaa aattggcact

2221 gctatctttg gaagagaggt aggctttcac tcacccaaag gcaaggagct ggccaggtga

2281 tcttgggggg catctgttct gctctactaa caaagacaca ggtcaggatt ttgttctgaa

2341 gatagagggg catggtggct ccgtataggt atctacttca taggtggcct tggtgggtcc

2401 cagatttcaa agaagagatg gaaactccca aaagtttgca caacctggca ccaggctatg

2461 tgccactcac tgatccttta gtccccgcac cgagcagtgg gacagtgctg gactgttcag

2521 aatgtggggc ctgggcagtg atgtgctggt aaatgttcaa caactgactc ttctgaagaa

2581 aagatccctg ctttataaca tttgttgatt ttcatggtat aaatgccccc actgtggtca

2641 gtttcaagct accaacatgc tgaatgtgga gtggggaaga gatgcacgca attggcattt

2701 ataaaccagt ataagccagc cagcgcacca taggcctggg tgtctttcac catcacagac

2761 tgctctactc tgctcagaga ctcaccaact cccaggctgg aagacactag cagtggaagg

2821 tccaggatcc agggctatac tgaccactgt gccagtggcc ttgaggcaga ctctgcagta

2881 gacaacancc agggctggcc nattagatga caacatgncc ttggtccctc tcgggcccaa

2941 cccagacacc tcctg

(2) INFORMATION FOR SEQ ID NO: 16: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1495 base pairs

(B) TYPE: nucleic acid EPI-109 1100

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 16: 1 atggaaactc caaacaccac agaggactat gacacgacca cagagtttga ctatggggat

61 gcaactccgt gccagaaggt gaacgagagg gcctttgggg cccaactgct gccccctctg

121 tactccttgg tatttgtcat tggcctggtt ggaaacatcc tggtggtcct ggtccttgtg

181 caatacaaga ggctaaaaaa catgaccagc atctacctcc tgaacctggc catttctgac

241 ctgctcttcc tgttcacgct tcccttctgg atcgactaca agttgaagga tgactgggtt

301 tttggtgatg ccatgtgtaa gatcctctct gggttttatt acacaggctt gtacagcgag

361 atctttttca tcatcctgct gacgattgac aggtacctgg ccatcgtcca cgccgtgttt

421 gccttgcggg cacggaccgt cacttttggt gtcatcacca gcatcatcat ttgggccctg

481 gccatcttgg cttccatgcc aggcttatac ttttccaaga cccaatggga attcactcac

541 cacacctgca gccttcactt tcctcacgaa agcctacgag agtggaagct gtttcaggct

601 ctgaaactga acctctttgg gctggtattg cctttgttgg tcatgatcat ctgctacaca

661 gggattataa agattctgct aagacgacca aatgagaaga aatccaaagc tgtccgtttg

721 atttttgtca tcatgatcat cttttttctc ttttggaccc cctacaattt gactatactt

781 atttctgttt tccaagactt cctgttcacc catgagtgtg agcagagcag acatttggac

841 ctggctgtgc aagtgacgga ggtgatcgcc tacacgcact gctgtgtcaa cccagtgatc

901 tacgccttcg ttggtgagag gttccggaag tacctgcggc agttgttcca caggcgtgtg

961 gctgtgcacc tggttaaatg gctccccttc ctctccgtgg acaggctgga gagggtcagc

1021 tccacatctc cctccacagg ggagcatgaa ctctctgctg ggttctgact cagaccatag

1081 gaggccaacc caaaataagc aggcgtgacc tgccaggcac actgaccagc agcctggctc

1141 tcccagccag gttctgactc ttggcacagc atggagtccg cctcttggat agagaggaat

1201 gtaatggtgg cctggggctt ctgaggcttc tgggcttgag tcttttccat gaacttctcc

1261 cctggtagaa aagaagatga atgagcaaaa ccaaatattc cagagactgg gactaagtgt

1321 accagagaag ggcttggact caagcaagat ttcagatttg tgaccattag catttgtcaa

1381 caaagtcacc cacttcccac tattgcttgc acaaaccaat taaacccagt agtggtgact

1441 gtgggctcca ttcaaagtga gctcctaagc catgggagac actgatgtat gagga

(2) INFORMATION FOR SEQ ID NO: 17: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 6606 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 17: 1 ggcacgagcc cagaaacaaa gacttcacgg acaaagtccc ttggaaccag agagaagccg

61 ggatggaaac tccaaacacc acagaggact atgacacgac cacagagttt gactatgggg

121 atgcaactcc gtgccagaag gtgaacgaga gggcctttgg ggcccaactg ctgccccctc

181 tgtactcctt ggtatttgtc attggcctgg ttggaaacat cctggtggtc ctggtccttg

241 tgcaatacaa gaggctaaaa aacatgacca gcatctacct cctgaacctg gccatttctg

301 acctgctctt cctgttcacg cttcccttct ggatcgacta caagttgaag gatgactggg

361 tttttggtga tgccatgtgt aagatcctct ctgggtttta ttacacaggc ttgtacagcg

421 agatcttttt catcatcctg ctgacgattg acaggtacct ggccatcgtc cacgccgtgt

481 ttgccttgcg ggcacggacc gtcacttttg gtgtcatcac cagcatcatc atttgggccc

541 tggccatctt ggcttccatg ccaggcttat acttttccaa gacccaatgg gaattcactc

601 accacacctg cagccttcac tttcctcacg aaagcctacg agagtggaag ctgtttcagg

661 ctctgaaact gaacctcttt gggctggtat tgcctttgtt ggtcatgatc atctgctaca

721 cagggattat aaagattctg ctaagacgac caaatgagaa gaaatccaaa gctgtccgtt

781 tgatttttgt catcatgatc atcttttttc tcttttggac cccctacaat ttgactatac

841 ttatttctgt tttccaagac ttcctgttca cccatgagtg tgagcagagc agacatttgg

901 acctggctgt gcaagtgacg gaggtgatcg cctacacgca ctgctgtgtc aacccagtga

961 tctacgcctt cgttggtgag aggttccgga agtacctgcg gcagttgttc cacaggcgtg

1021 tggctgtgca cctggttaaa tggctcccct tcctctccgt ggacaggctg gagagggtca

1081 gctccacatc tccctccaca ggggagcatg aactctctgc tgggttctga ctcagaccat

1141 aggaggccaa cccaaaataa gcaggcgtga cctgccaggc acactgagcc agcagcctgg

1201 ctctcccagc caggttctga ctcttggcac agcatggagt cacagccact tgggatagag

1261 agggaatgta atggtggcct ggggcttctg aggcttctgg ggcttcagtc ttttccatga

1321 acttctcccc tggtagaaag aagatgaatg agcaaaacca aatattccag agactgggac

1381 taagtgtacc agagaagggc ttggactcaa gcaagatttc agatttgtga ccattagcat

1441 ttgtcaacaa agtcacccac ttcccactat tgcttgcaca aaccaattaa acccagtagt

1501 ggtgactgtg ggctccattc aaagtgagct cctaagccat gggagacact gatgtatgag

1561 gaatttctgt tcttccatca cctccccccc cccgccaccc tcccactgcc aagaacttgg

1621 aaatagtgat ttccacagtg actccactct gagtcccaga gccaatcagt agccagcatc

1681 tgcctcccct tcactcccac cgcaggattt gggctcttgg aatcctgggg aacatagaac

1741 tcatgacgga agagttgaga cctaacgaga aatagaaatg ggggaactac tgctggcagt

1801 ggaactaaga aagcccttag gaagaatttt tatatccact aaaatcaaac aattcaggga

1861 gtgggctaag cacgggccat atgaataaca tggtgtgctt cttaaaatag ccataaaggg

1921 gagggactca tcatttccat ttacccttct tttctgacta tttttcagaa tctctcttct EPI-109 1101

1981 tttcaagttg ggtgatatgt tggtagattc taatggcttt attgcagcga ttaataacag 2041 gcaaaaggaa gcagggttgg tttcccttct ttttgttctt catctaagcc ttctggtttt 2101 atgggtcaga gttccgactg ccatcttgga cttgtcagca aaaaaaaaaa aaaaaa 1 gagagccccc cccccgagac tgaaagtttt ggagattcag gggtcggggg aaagggttca

61 ggaaatggta attgagtttc caagggatag tgttacaagt ggtatgggag gccccctatt

121 tctgatagta atagagaata ttttctttgt tcattatgat agaacccgtg ggataaagag

181 ggaaaataaa tgttgggagt cccccagggg agaggagaga atccaacagg gtgatttgct

241 gatatttgta cgaggaggga aagaattttt caaagacaaa gttggagtga ggagtttttg

301 tagagggaac caggtggggt acaaagagag agacacactg agccggtggg aagggaagaa

361 ttaagagggg tgttccccca cactgtatat taagaaagaa aaacaatggg gacaggacgg

421 cagaagttag agtttcttaa ccaggatgag agggggattt cacggtaact aatgagtgat

481 ttcagacctt attccactat cccagggcaa tcagatatta atcatgtaca agttgaaatc

541 atgcgtgtcc tttgaggtaa gacttacata atcctattta gcataacagg cccccagatc

601 cagaaagggg agggttccgc ccctatcact gaaggggatc agggatatga aagtggctca

661 tggttgacca tcacgtttaa caggaatggg caatcaggag gggtaggtcc aattgtgacc

721 aacagaccaa acttccatta atgcttgcgg ttcttgtggc aaagccagtc tgtgaggttt

781 gatggggatg gacttggtga gcagagagca gggggacaac gaatcccaga agctgagggg

841 aatggggttc caaagagccg ctgctgcctc tgggagcacc catgtcagtt agtttttccg

901 tacgggactc agggttccag attattcgtt tttaaatcct tccattcaca atctttaaga

961 agaagaaaaa aaagaagtct gccgctgacc acaagagctc tatgccctgc ccccatccca

1021 catacacaca tcccacactt caattgctcc aaacattctg ggaacatctc actgccaccc

1081 acctcaccca actcagcttc acctgccccc aattccctta aggctgagct cccagggcca

1141 agactcaaga ggctcagagt gagcagagaa aatcctcgca gttaacttgg cttccaggaa

1201 gtggccactg gtgggcgttg tggccattca tgagcaccaa accacacaaa aagaactttg

1261 tccctttctt gtcattttga aagactgtga aactggagcc aattctccat catcacacag

1321 gaagctgagt acttcctact tggtcaggat cttgaaactt gaattcataa aacccagaaa

1381 gccccagaaa caaagacttc acggacaaag tcccttggaa ccagagtaag tgtcacttgt

1441 cttttctgtc ttatctgtta ctgtggaggg cagtgttgtt caaagacatg catgcagcta

1501 ggggctcctc aaaggtaggg ggaattcttt gagtaggctg ggcaaatgtc taagtagccc

1561 atggatgcat ctccaaggca attaatactg tagcaatact gagaatggtg gatttataaa

1621 gctgggtgct cagatgaaat ataggctttt ttgctaaaaa ggaagcttac ttgaaggatt

1681 ggcttttggt tactgattaa gaaagtcagt cagtactaag ggacaaaagg tgttttctgt

1741 ggaaacctat tcaataagaa attacttggc ggggcgcagt ggctcacggc tgtaatccca

1801 gcactttggg agaccgaggc aggtggatca tgaggtcaag agatggagac aatcctggcc

1861 atatggtgaa accctgtctc tactaaaaat aaaaattagc cgggcaggtg gccgcagcct

1921 gttagtccca gctactcaag aggctgaggc aggagaatca ctcgaatccg ggaggtggag

1981 gttgcagtga gctgagattg caccacaaca ctccagcctg gcgacagagc aagagtctgt

2041 ctgaaaaaaa aaaattgctt gccaaattcc cccaagtaaa ggaaaaccaa acatggtgta

2101 tgaagaaatt atagcaagag ggaaatatta gctagaaaaa tcttggcaga tgcaaggatg

2161 atttgatact gaacctatct cttaagaaga ctagaaccaa ggatcctcaa aattggcact

2221 gctatctttg gaagagaggt aggctttcac tcacccaaag gcaaggagct ggccaggtga

2281 tcttgggggg catctgttct gctctactaa caaagacaca ggtcaggatt ttgttctgaa

2341 gatagagggg catggtggct ccgtataggt atctacttca taggtggcct tggtgggtcc

2401 cagatttcaa agaagagatg gaaactccca aaagtttgca caacctggca ccaggctatg

2461 tgccactcac tgatccttta gtccccgcac cgagcagtgg gacagtgctg gactgttcag

2521 aatgtggggc ctgggcagtg atgtgctggt aaatgttcaa caactgactc ttctgaagaa

2581 aagatccctg ctttataaca tttgttgatt ttcatggtat aaatgccccc actgtggtca

2641 gtttcaagct accaacatgc tgaatgtgga gtggggaaga gatgcacgca attggcattt

2701 ataaaccagt ataagccagc cagcgcacca taggcctggg tgtctttcac catcacagac

2761 tgctctactc tgctcagaga ctcaccaact cccaggctgg aagacactag cagtggaagg

2821 tccaggatcc agggctatac tgaccactgt gccagtggcc ttgaggcaga ctctgcagta

2881 gacaacancc agggctggcc nattagatga caacatgncc ttggtccctc tcgggcccaa

2941 cccagacacc tcctg

1 atggaaactc caaacaccac agaggactat gacacgacca cagagtttga ctatggggat

61 gcaactccgt gccagaaggt gaacgagagg gcctttgggg cccaactgct gccccctctg 121 tactccttgg tatttgtcat tggcctggtt ggaaacatcc tggtggtcct ggtccttgtg 181 caatacaaga ggctaaaaaa catgaccagc atctacctcc tgaacctggc catttctgac 241 ctgctcttcc tgttcacgct tcccttctgg atcgactaca agttgaagga tgactgggtt 301 tttggtgatg ccatgtgtaa gatcctctct gggttttatt acacaggctt gtacagcgag 361 atctttttca tcatcctgct gacgattgac aggtacctgg ccatcgtcca cgccgtgttt 421 gccttgcggg cacggaccgt cacttttggt gtcatcacca gcatcatcat ttgggccctg 481 gccatcttgg cttccatgcc aggcttatac ttttccaaga cccaatggga attcactcac 541 cacacctgca gccttcactt tcctcacgaa agcctacgag agtggaagct gtttcaggct 601 ctgaaactga acctctttgg gctggtattg cctttgttgg tcatgatcat ctgctacaca 661 gggattataa agattctgct aagacgacca aatgagaaga aatccaaagc tgtccgtttg 721 atttttgtca tcatgatcat cttttttctc ttttggaccc cctacaattt gactatactt 781 atttctgttt tccaagactt cctgttcacc catgagtgtg agcagagcag acatttggac 841 ctggctgtgc aagtgacgga ggtgatcgcc tacacgcact gctgtgtcaa cccagtgatc EPI-109 1 102

901 tacgccttcg ttggtgagag gttccggaag tacctgcggc agttgttcca caggcgtgtg

961 gctgtgcacc tggttaaatg gctccccttc ctctccgtgg acaggctgga gagggtcagc

1021 tccacatctc cctccacagg ggagcatgaa ctctctgctg ggttctgact cagaccatag

1081 gaggccaacc caaaataagc aggcgtgacc tgccaggcac actgaccagc agcctggctc

1141 tcccagccag gttctgactc ttggcacagc atggagtccg cctcttggat agagaggaat

1201 gtaatggtgg cctggggctt ctgaggcttc tgggcttgag tcttttccat gaacttctcc

1261 cctggtagaa aagaagatga atgagcaaaa ccaaatattc cagagactgg gactaagtgt

1321 accagagaag ggcttggact caagcaagat ttcagatttg tgaccattag catttgtcaa

1381 caaagtcacc cacttcccac tattgcttgc acaaaccaat taaacccagt agtggtgact

1441 gtgggctcca ttcaaagtga gctcctaagc catgggagac actgatgtat gagga

(2) INFORMATION FOR SEQ ID NO: 18: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1068 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 18: 1 atgacaacct cactagatac agttgagacc tttggtacca catcctacta tgatgacgtg

61 ggcctgctct gtgaaaaagc tgataccaga gcactgatgg cccagtttgt gcccccgctg

121 tactccctgg tgttcactgt gggcctcttg ggcaatgtgg tggtggtgat gatcctcata

181 aaatacagga ggctccgaat tatgaccaac atctacctgc tcaacctggc catttcggac

241 ctgctcttcc tcgtcaccct tccattctgg atccactatg tcagggggca taactgggtt

301 tttggccatg gcatgtgtaa gctcctctca gggttttatc acacaggctt gtacagcgag

361 atctttttca taatcctgct gacaatcgac aggtacctgg ccattgtcca tgctgtgttt

421 gcccttcgag cccggactgt cacttttggt gtcatcacca gcatcgtcac ctggggcctg

481 gcagtgctag cagctcttcc tgaatttatc ttctatgaga ctgaagagtt gtttgaagag

541 actctttgca gtgctcttta cccagaggat acagtatata gctggaggca tttccacact

601 ctgagaatga ccatcttctg tctcgttctc cctctgctcg ttatggccat ctgctacaca

661 ggaatcatca aaacgctgct gaggtgcccc agtaaaaaaa agtacaaggc catccggctc

721 atttttgtca tcatggcggt gtttttcatt ttctggacac cctacaatgt ggctatcctt

781 ctctcttcct atcaatccat cttatttgga aatgactgtg agcggagcaa gcatctggac

841 ctggtcatgc tggtgacaga ggtgatcgcc tactcccact gctgcatgaa cccggtgatc

901 tacgcctttg ttggagagag gttccggaag tacctgcgcc acttcttcca caggcacttg

961 ctcatgcacc tgggcagata catcccattc cttcctagtg agaagctgga aagaaccagc

1021 tctgtctctc catccacagc agagccggaa ctctctattg tgttttag

(2) INFORMATION FOR SEQ ID NO: 19: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1201 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 19: 1 tttttcttct tctatcacag ggagaagtga aatgacaacc tcactagata cagttgagac

61 ctttggtacc acatcctact atgatgacgt gggcctgctc tgtgaaaaag ctgataccag

121 agcactgatg gcccagtttg tgcccccgct gtactccctg gtgttcactg tgggcctctt

181 gggcaatgtg gtggtggtga tgatcctcat aaaatacagg aggctccgaa ttatgaccaa

241 catctacctg ctcaacctgg ccatttcgga cctgctcttc ctcgtcaccc ttccattctg

301 gatccactat gtcagggggc ataactgggt ttttggccat ggcatgtgta agctcctctc

361 agggttttat cacacaggct tgtacagcga gatctttttc ataatcctgc tgacaatcga

421 caggtacctg gccattgtcc atgctgtgtt tgcccttcga gcccggactg tcacttttgg

481 tgtcatcacc agcatcgtca cctggggcct ggcagtgcta gcagctcttc ctgaatttat

541 cttctatgag actgaagagt tgtttgaaga gactctttgc agtgctcttt acccagagga

601 tacagtatat agctggaggc atttccacac tctgagaatg accatcttct gtctcgttct

661 ccctctgctc gttatggcca tctgctacac aggaatcatc aaaacgctgc tgaggtgccc

721 cagtaaaaaa aagtacaagg ccatccggct catttttgtc atcatggcgg tgtttttcat

781 tttctggaca ccctacaatg tggctatcct tctctcttcc tatcaatcca tcttatttgg

841 aaatgactgt gagcggagca agcatctgga cctggtcatg ctggtgacag aggtgatcgc

901 ctactcccac tgctgcatga acccggtgat ctacgccttt gttggagaga ggttccggaa

961 gtacctgcgc cacttcttcc acaggcactt gctcatgcac ctgggcagat acatcccatt

1021 ccttcctagt gagaagctgg aaagaaccag ctctgtctct ccatccacag cagagccgga

1081 actctctatt gtgttttagg tcagatgcag aaaattgcct aaagaggaag gaccaaggag

1141 atgaagcaaa cacattaagc cttccacact cacctctaaa acagtccttc aaacttccag

1201 t

(2) INFORMATION FOR SEQ ID NO: 20: (l) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1699 base pairs EPI-109 1 103

( B ) TYPE : nucleic acid

( C ) STRANDEDNESS : s ingle

( D) TOPOLOGY : linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 20: 1 aatccttttc ctggcacctc tgatatcctt ttgaaattca tgttaaagaa tccctaggct

61 gctatcacat gtggcatctt tgttgagtac atgaataaat caactggtgt gttttacgga

121 ggatgattat gcttcattgt gggattgtat ttttcttctt ctatcacagg gagaagtgaa

181 atgacaacct cactagatac agttgagacc tttggtacca catcctacta tgatgacgtg

241 ggcctgctct gtgaaaaagc tgataccaga gcactgatgg cccagtttgt gcccccgctg

301 tactccctgg tgttcactgt gggcctcttg ggcaatgtgg tggtggtgat gatcctcata

361 aaatacagga ggctccgaat tatgaccaac atctacctgc tcaacctggc catttcggac

421 ctgctcttcc tcgtcaccct tccattctgg atccactatg tcagggggca taactgggtt

481 tttggccatg gcatgtgtaa gctcctctca gggttttatc acacaggctt gtacagcgag

541 atctttttca taatcctgct gacaatcgac aggtacctgg ccattgtcca tgctgtgttt

601 gcccttcgag cccggactgt cacttttggt gtcatcacca gcatcgtcac ctggggcctg

661 gcagtgctag cagctcttcc tgaatttatc ttctatgaga ctgaagagtt gtttgaagag

721 actctttgca gtgctcttta cccagaggat acagtatata gctggaggca tttccacact

781 ctgagaatga ccatcttctg tctcgttctc cctctgctcg ttatggccat ctgctacaca

841 ggaatcatca aaacgctgct gaggtgcccc agtaaaaaaa agtacaaggc catccggctc

901 atttttgtca tcatggcggt gtttttcatt ttctggacac cctacaatgt ggctatcctt

961 ctctcttcct atcaatccat cttatttgga aatgactgtg agcggacgaa gcatctggac

1021 ctggtcatgc tggtgacaga ggtgatcgcc tactcccact gctgcatgaa cccggtgatc

1081 tacgcctttg ttggagagag gttccggaag tacctgcgcc acttcttcca caggcacttg

1141 ctcatgcacc tgggcagata catcccattc cttcctagtg agaagctgga aagaaccagc

1201 tctgtctctc catccacagc agagccggaa ctctctattg tgttttaggt agatgcagaa

1261 aattgcctaa agaggaagga ccaaggagat naagcaaaca cattaagcct tccacactca

1321 cctctaaaac agtccttcaa accttccagt gcaacactga agctcttaag acactgaaat

1381 atacacacag cagtagcagt agatgcatgt accctaaggt cattaccaca ggccagggct

1441 gggcagcgta ctcatcatca acctaaaaag cagagctttg cttctctctc taaaatgagt

1501 tacctatatt ttaatgcacc tgaatgttag atagttacta tatgccgcta caaaaaggta

1561 aaacttttta tattttatac attaacttca gccagctatt atataaataa aacattttca

1621 cacaatacaa taagttaact attttatttt ctaatgtgcc tagttctttc cctgcttaat

1681 gaaaagctt

(2) INFORMATION FOR SEQ ID NO: 21: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2968 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 21:

1 atgacaacct cactagatac agttgagacc tttggtacca catcctacta tgatgacgtg

61 ggcctgctct gtgaaaaagc tgataccaga gcactgatgg cccagtttgt gcccccgctg

121 tactccctgg tgttcactgt gggcctcttg ggcaatgtgg tggtggtgat gatcctcata

181 aaatacagga ggctccgaat tatgaccaac atctacctgc tcaacctggc catttcggac

241 ctgctcttcc tcgtcaccct tccattctgg atccactatg tcagggggca taactgggtt

301 tttggccatg gcatgtgtaa gctcctctca gggttttatc acacaggctt gtacagcgag

361 atctttttca taatcctgct gacaatcgac aggtacctgg ccattgtcca tgctgtgttt

421 gcccttcgag cccggactgt cacttttggt gtcatcacca gcatcgtcac ctggggcctg

481 gcagtgctag cagctcttcc tgaatttatc ttctatgaga ctgaagagtt gtttgaagag

541 actctttgca gtgctcttta cccagaggat acagtatata gctggaggca tttccacact

601 ctgagaatga ccatcttctg tctcgttctc cctctgctcg ttatggccat ctgctacaca

661 ggaatcatca aaacgctgct gaggtgcccc agtaaaaaaa agtacaaggc catccggctc

721 atttttgtca tcatggcggt gtttttcatt ttctggacac cctacaatgt ggctatcctt

781 ctctcttcct atcaatccat cttatttgga aatgactgtg agcggagcaa gcatctggac

841 ctggtcatgc tggtgacaga ggtgatcgcc tactcccact gctgcatgaa cccggtgatc

901 tacgcctttg ttggagagag gttccggaag tacctgcgcc acttcttcca caggcacttg

961 ctcatgcacc tgggcagata catcccattc cttcctagtg agaagctgga aagaaccagc

1021 tctgtctctc catccacagc agagccggaa ctctctattg tgttttag

1 tttttcttct tctatcacag ggagaagtga aatgacaacc tcactagata cagttgagac

61 ctttggtacc acatcctact atgatgacgt gggcctgctc tgtgaaaaag ctgataccag

121 agcactgatg gcccagtttg tgcccccgct gtactccctg gtgttcactg tgggcctctt

181 gggcaatgtg gtggtggtga tgatcctcat aaaatacagg aggctccgaa ttatgaccaa

241 catctacctg ctcaacctgg ccatttcgga cctgctcttc ctcgtcaccc ttccattctg

301 gatccactat gtcagggggc ataactgggt ttttggccat ggcatgtgta agctcctctc

361 agggttttat cacacaggct tgtacagcga gatctttttc ataatcctgc tgacaatcga

421 caggtacctg gccattgtcc atgctgtgtt tgcccttcga gcccggactg tcacttttgg

481 tgtcatcacc agcatcgtca cctggggcct ggcagtgcta gcagctcttc ctgaatttat

541 cttctatgag actgaagagt tgtttgaaga gactctttgc agtgctcttt acccagagga EPI-109 1104

601 tacagtatat agctggaggc atttccacac tctgagaatg accatcttct gtctcgttct

661 ccctctgctc gttatggcca tctgctacac aggaatcatc aaaacgctgc tgaggtgccc

721 cagtaaaaaa aagtacaagg ccatccggct catttttgtc atcatggcgg tgtttttcat

781 tttctggaca ccctacaatg tggctatcct tctctcttcc tatcaatcca tcttatttgg

841 aaatgactgt gagcggagca agcatctgga cctggtcatg ctggtgacag aggtgatcgc

901 ctactcccac tgctgcatga acccggtgat ctacgccttt gttggagaga ggttccggaa

961 gtacctgcgc cacttcttcc acaggcactt gctcatgcac ctgggcagat acatcccatt

1021 ccttcctagt gagaagctgg aaagaaccag ctctgtctct ccatccacag cagagccgga

1081 actctctatt gtgttttagg tcagatgcag aaaattgcct aaagaggaag gaccaaggag

1141 atgaagcaaa cacattaagc cttccacact cacctctaaa acagtccttc aaacttccag

1201 t

1 aatccttttc ctggcacctc tgatatcctt ttgaaattca tgttaaagaa tccctaggct

61 gctatcacat gtggcatctt tgttgagtac atgaataaat caactggtgt gttttacgga

121 ggatgattat gcttcattgt gggattgtat ttttcttctt ctatcacagg gagaagtgaa

181 atgacaacct cactagatac agttgagacc tttggtacca catcctacta tgatgacgtg

241 ggcctgctct gtgaaaaagc tgataccaga gcactgatgg cccagtttgt gcccccgctg

301 tactccctgg tgttcactgt gggcctcttg ggcaatgtgg tggtggtgat gatcctcata

361 aaatacagga ggctccgaat tatgaccaac atctacctgc tcaacctggc catttcggac

421 ctgctcttcc tcgtcaccct tccattctgg atccactatg tcagggggca taactgggtt

481 tttggccatg gcatgtgtaa gctcctctca gggttttatc acacaggctt gtacagcgag

541 atctttttca taatcctgct gacaatcgac aggtacctgg ccattgtcca tgctgtgttt

601 gcccttcgag cccggactgt cacttttggt gtcatcacca gcatcgtcac ctggggcctg

661 gcagtgctag cagctcttcc tgaatttatc ttctatgaga ctgaagagtt gtttgaagag

721 actctttgca gtgctcttta cccagaggat acagtatata gctggaggca tttccacact

781 ctgagaatga ccatcttctg tctcgttctc cctctgctcg ttatggccat ctgctacaca

841 ggaatcatca aaacgctgct gaggtgcccc agtaaaaaaa agtacaaggc catccggctc

901 atttttgtca tcatggcggt gtttttcatt ttctggacac cctacaatgt ggctatcctt

961 ctctcttcct atcaatccat cttatttgga aatgactgtg agcggacgaa gcatctggac

1021 ctggtcatgc tggtgacaga ggtgatcgcc tactcccact gctgcatgaa cccggtgatc

1081 tacgcctttg ttggagagag gttccggaag tacctgcgcc acttcttcca caggcacttg

1141 ctcatgcacc tgggcagata catcccattc cttcctagtg agaagctgga aagaaccagc

1201 tctgtctctc catccacagc agagccggaa ctctctattg tgttttaggt agatgcagaa

1261 aattgcctaa agaggaagga ccaaggagat naagcaaaca cattaagcct tccacactca

1321 cctctaaaac agtccttcaa accttccagt gcaacactga agctcttaag acactgaaat

1381 atacacacag cagtagcagt agatgcatgt accctaaggt cattaccaca ggccagggct

1441 gggcagcgta ctcatcatca acctaaaaag cagagctttg cttctctctc taaaatgagt

1501 tacctatatt ttaatgcacc tgaatgttag atagttacta tatgccgcta caaaaaggta

1561 aaacttttta tattttatac attaacttca gccagctatt atataaataa aacattttca

1621 cacaatacaa taagttaact attttatttt ctaatgtgcc tagttctttc cctgcttaat

1681 gaaaagctt

(2) INFORMATION FOR SEQ ID NO: 22: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2961 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:22: 1 tctagagcca aggtcacgga agcccagagg gcatcttgtg gctcgggagt agctctctgc

61 tgtcttctca gctctgctga caatacttga gattttcaga tgtcaccaac caccaagaga

121 gcttgatatg actgtatata gtatagtcat aaagaacctg aacttgacca tatacttatg

181 tcatgtggaa aatttctcat agcttcagat agattatatc tggagtgaag aatcctgcca

241 cctatgtatc tggcatagtg tgagtcctca taaatgctta ctggtttgaa gggcaacaaa

301 atagtgaaca gagtgaaaat ccccactaag atcctgggtc cagaaaaaga tgggaaacct

361 gtttagctca cccgtgagcc catagttaaa actctttaga caacaggttt tttccgttta

421 cagagaacaa taatattggg tggtgagcat ctgtgtgggg gttggggtgg gataggggat

481 acggggagag tggagaaaaa gggggcacag ggttaatgtg aagtccagga tccccctcta

541 catttaaagt tggtttaagt tggctttaat taatagcaac tcttaagata atcagaattt

601 tcttaacctt ttagccttac tgttgaaaag ccctgtgatc ttgtacaaat catttgcttc

661 ttggatagta atttctttta ctaaaatgtg ggcttttgac tagatgaatg taaatgttct

721 tctagctctg atatccttta ttctttatat tttctaacag attctgtgta gtgggatgag

781 cagagaacaa aaacaaaata atccagtgag aaaagcccgt aaataaactt tcagaccaga

841 gatctattct ctagcttatt ttaagctcaa cttaaaagga agaactgttc tctgattctt

901 ttcgccttca atacacttaa tgatttaact ccaccctcct tcaaaagaaa cagcatttcc

961 tacttttata ctgtctatat gattgatttg cacagctcat ctggccagaa gagctgagac

1021 atccgttccc ctacaagaaa ctctccccgg taagtaacct ctcagctgct tggcctgtta

1081 gttagcttct gagatgagta aaagacttta caggaaaccc atagaagaca tttggcaaac

1141 accaagtgct catacaatta tcttaaaata taatctttaa gataaggaaa gggtcacagt

1201 ttggaatgag tttcagacgg ttataacatc aaagatacaa aacatgattg tgagtgaaag EPI-109 1105

1261 actttaaagg gagcaatagt attttaataa ctaacaatcc ttacctctca aaagaaagat

1321 ttgcagagag atgagtctta gctgaaatct tgaaatctta tcttctgcta aggagaacta

1381 aaccctctcc agtgagatgc cttctgaata tgtgcccaca agaagttgtg tctaagtctg

1441 gttctctttt ttctttttcc tccagacaag agggaagcct aaaaatggtc aaaattaata

1501 ttaaattaca aacgccaaat aaaattttcc tctaatatat cagtttcatg gcacagttag

1561 tatataattc tttatggttc aaaattaaaa atgagctttt ctaggggctt ctctcagctg

1621 cctagtctaa ggtgcaggga gtttgagact cacagggttt aataagagaa aattctcagc

1681 tagagcagct gaacttaaat agactaggca agacagctgg ttataagact aaactaccca

1741 gaatgcatga cattcatctg tggtggcaga cgaaacattt tttattatat tatttcttgg

1801 gtatgtatga caactcttaa ttgtggcaac tcaaactaca aacacaaact tcacagaaaa

1861 tgtgaggatt ttacaattgg ctgttgtcat ctatgacctt ccctgggact tgggcacccg

1921 gccatttcac tctgactaca tcatgtcacc aaacatctga tggtcttgcc ttttaattct

1981 ctttttgagg actgagaggg agggtagcat ggtagttaag agtgcaggct tcccgcattc

2041 aaaatcggtt gcttactagc tgtgtggctt tgagcaagtt actcaccctc tctgtgcttc

2101 aaggtccttg tctgcaaaat gtgaaaaata tttcctgcct cataaggttg ccctaaggat

2161 taaatgaatg aatgggtatg atgcttagaa cagtgattgg catccagtat gtgccctcga

2221 ggcctcttaa ttattactgg cttgctcata gtgcatgttc tttgtgggct aactctagcg

2281 tcaataaaaa tgttaagact gagttgcagc tgggcatggt ggctcatgcc tgtaatccca

2341 gcattctagg aggctgaggc aggaggatcg cttgagccca ggagttcgag accagcctgg

2401 gcaacatagt gtgatcttgt atctataaaa ataaacaaaa ttagcttggt gtggtggcgc

2461 ctgtagtccc cagccacttg gaggggtgag gtgagaggat tgcttgagcc cgggatgatc

2521 caggctgcag tgagccatga tcgtgccact gcactccagc ctgggcgaca gagtgagacc

2581 ctgtctcaca acaacaacag caacaaaaag gctgagctgc accatgcttg acccagtttc

2641 ttaaaattgt tgtcaaagct tcattcactc catggtgcta tagagcacaa gattttattt

2701 ggtgagatgg tgctttcatg aattccccca acagagccaa gctctccatc tagtggacag

2761 ggaagctagc agcaaacctt cccttcacta caaaacttca ttgcttggcc aaaaagagag

2821 ttaattcaat gtagacatct atgtaggcaa ttaaaaacct attgatgtat aaaacagttt

2881 gcattcatgg agggcaacta aatacattct aggactttat aaaagatcac tttttattta

2941 tgcacagggt ggaacaagat g

(2) INFORMATION FOR SEQ ID NO: 23: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3383 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:23: 1 agaagagctg agacatccgt tcccctacaa gaaactctcc ccgggtggaa caagatggat

61 tatcaagtgt caagtccaat ctatgacatc aattattata catcggagcc ctgccaaaaa

121 atcaatgtga agcaaatcgc agcccgcctc ctgcctccgc tctactcact ggtgttcatc

181 tttggttttg tgggcaacat gctggtcatc ctcatcctga taaactgcaa aaggctgaag

241 agcatgactg acatctacct gctcaacctg gccatctctg acctgttttt ccttcttact

301 gtccccttct gggctcacta tgctgccgcc cagtgggact ttggaaatac aatgtgtcaa

361 ctcttgacag ggctctattt tataggcttc ttctctggaa tcttcttcat catcctcctg

421 acaatcgata ggtacctggc tgtcgtccat gctgtgtttg ctttaaaagc caggacggtc

481 acctttgggg tggtgacaag tgtgatcact tgggtggtgg ctgtgtttgc gtctctccca

541 ggaatcatct ttaccagatc tcaaaaagaa ggtcttcatt acacctgcag ctctcatttt

601 ccatacagtc agtatcaatt ctggaagaat ttccagacat taaagatagt catcttgggg

661 ctggtcctgc cgctgcttgt catggtcatc tgctactcgg gaatcctaaa aactctgctt

721 cggtgtcgaa atgagaagaa gaggcacagg gctgtgaggc ttatcttcac catcatgatt

781 gtttattttc tcttctgggc tccctacaac attgtccttc tcctgaacac cttccaggaa

841 ttctttggcc tgaataattg cagtagctct aacaggttgg accaagctat gcaggtgaca

901 gagactcttg ggatgacgca ctgctgcatc aaccccatca tctatgcctt tgtcggggag

961 aagttcagaa actacctctt agtcttcttc caaaagcaca ttgccaaacg cttctgcaaa

1021 tgctgttcta ttttccagca agaggctccc gagcgagcaa gctcagttta cacccgatcc

1081 actggggagc aggaaatatc tgtgggcttg tgacacggac tcaagtgggc tggtgaccca

1141 gtcagagttg tgcacatggc ttagttttca tacacagcct gggctggggg tggggtggga

1201 gaggtctttt ttaaaaggaa gttactgtta tagagggtct aagattcatc catttatttg

1261 gcatctgttt aaagtagatt agatctttta agcccatcaa ttatagaaag ccaaatcaaa

1321 atatgttgat gaaaaatagc aaccttttta tctccccttc acatgcatca agttattgac

1381 aaactctccc ttcactccga aagttcctta tgtatattta aaagaaagcc tcagagaatt

1441 gctgattctt gagtttagtg atctgaacag aaataccaaa attatttcag aaatgtacaa

1501 ctttttacct agtacaaggc aacatatagg ttgtaaatgt gtttaaaaca ggtctttgtc

1561 ttgctatggg gagaaaagac atgaatatga ttagtaaaga aatgacactt ttcatgtgtg

1621 atttcccctc caaggtatgg ttaataagtt tcactgactt agaaccaggc gagagacttg

1681 tggcctggga gagctgggga agcttcttaa atgagaagga atttgagttg gatcatctat

1741 tgctggcaaa gacagaagcc tcactgcaag cactgcatgg gcaagcttgg ctgtagaagg

1801 agacagagct ggttgggaag acatggggag gaaggacaag gctagatcat gaagaacctt

1861 gacggcattg ctccgtctaa gtcatgagct gagcagggag atcctggttg gtgttgcaga EPI-109 1106

1921 aggtttactc tgtggccaaa ggagggtcag gaaggatgag catttagggc aaggagacca

1981 ccaacagccc tcaggtcagg gtgaggatgg cctctgctaa gctcaaggcg tgaggatggg

2041 aaggagggag gtattcgtaa ggatgggaag gagggaggta ttcgtgcagc atatgaggat

2101 gcagagtcag cagaactggg gtggatttgg tttggaagtg agggtcagag aggagtcaga

2161 gagaatccct agtcttcaag cagattggag aaacccttga aaagacatca agcacagaag

2221 gaggaggagg aggtttaggt caagaagaag atggattggt gtaaaaggat gggtctggtt

2281 tgcagagctt gaacacagtc tcacccagac tccaggctgt ctttcactga atgcttctga

2341 cttcatagat ttccttccca tcccagctga aatactgagg ggtctccagg aggagactag

2401 atttatgaat acacgaggta tgaggtctag gaacatactt cagctcacac atgagatcta

2461 ggtgaggatt gattacctag tagtcatttc atgggttgtt gggaggattc tatgaggcaa

2521 ccacaggcag catttagcac atactacaca ttcaataagc atcaaactct tagttactca

2581 ttcagggata gcactgagca aagcattgag caaaggggtc ccatataggt gagggaagcc

2641 tgaaaaacta agatgctgcc tgcccagtgc acacaagtgt aggtatcatt ttctgcattt

2701 aaccgtcaat aggcaaaggg gggaagggac atattcattt ggaaataagc tgccttgagc

2761 cttaaaaccc acaaaagtac aatttaccag cctccgtatt tcagactgaa tgggggtggg

2821 gggggcgcct taggtactta ttccagatgc cttctccaga caaaccagaa gcaacagaaa

2881 aaatcgtctc tccctccctt tgaaatgaat atacccctta gtgtttgggt atattcattt

2941 caaagggaga gagagaggtt tttttctgtt ctttctcata tgattgtgca catacttgag

3001 actgttttga atttggggga tggctaaaac catcatagta caggtaaggt gagggaatag

3061 taagtggtga gaactactca gggaatgaag gtgtcagaat aataagaggt gctactgact

3121 ttctcagcct ctgaatatga acggtgagca ttgtggctgt cagcaggaag caacgaaggg

3181 aaatgtcttt ccttttgctc ttaagttgtg gagagtgcaa cagtagcata ggaccctacc

3241 ctctgggcca agtcaaagac attctgacat cttagtattt gcatattctt atgtatgtga

3301 aagttacaaa ttgcttgaaa gaaaatatgc atctaataaa aaacaccttc taaaataaaa

3361 aaaaaaaaaa aaaaaaaaaa aaa

(2) INFORMATION FOR SEQ ID NO: 24: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 143068 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 24: 1 aagcttcagt atgcaaattt tcaatgacat gtgcctgtgg attctgaaaa ttcacagatc

61 tgtctatcct tagctgagac tgaaggcatc tacttcccaa tgaccaaatc ctggtgctgt

121 ggcgacactg agcaggaact ccattagaat atcaatatca ctctgcagac attccatgat

181 gtaagctatg ttttctcttg ttgcaattac acttaattta ccaccagctg cttcaatgtc

241 atgggctatc ttgaaaaatg aagctccttt cgtagtcaaa ctggatgcaa gacacagcaa

301 atgagaagtt actaaattgt tggagtcctc atagctactg cctgctttaa tgaacaaacc

361 aattcttgat gcagggcata gttttccaaa ggagaaatca taaaaccatt tggaaatttg

421 atgatctcaa ggtcctgatg atgtggagcc actcctatgg gggtagctgt ggctttaact

481 ttgggggcaa ctttgaggga ataaagtctc aaaaagaggg aataaagtct caagattgtt

541 cgtgacccat agtaacttct ggcttaaagg accattcggc aagtttttaa atgtattttc

601 tataatttcc atgtagttct ttatattttc tatttcttat ttaaaacctc tattttagct

661 cgtttccttt gacactgctc tggcagggaa aggggtggca ctgcctcatt actgccaggt

721 aggggtagaa gtccattatc cacttggtct ccattgatac ccaaagtggg gagaggctcc

781 tgttactgct ggtgagggtg ggagtccccc cactaagttt ctgctaatac tgtcctggtg

841 gcttgctact attcccatga agcctccact gatactacat tacttttggg tggtggcaaa

901 tgtcctgcct ctccactagc cctcctgctc taaaacaacc cgagtaggga gtgggaagga

961 agctttgtta ctggtaggtg ggagctgaag tccagacttg ccacattgtc ccactgatgc

1021 tacagggagg aggaagcggg ccacattact gcctgatagg gatgaaagcc ccagctccct

1081 acctggcctt cgctgatacc agcctgctac aggagtgaag agagatttga aggcctcaat

1141 atagcctgtc gagggtggaa gtcttgctcc caatgggcct ttagcagcat gggtgggtgt

1201 ggggccatag ctgtctctgt actgcttggc tagagtggag tatttgaggt ccaaaagttt

1261 tctgtctttc tagccctttg gttagaaaga gcagactttt gttggaagta tttttttgtg

1321 tttacctgtt gtatttccag gttcctagct tctccagcac agtctgggat gtgtgagaca

1381 cagagaaaat ccagtgatgt tactaccgta tggtttcttg ggtcccaacg tctctagcta

1441 atctgctcca ccttttggag ttttcttatt tgttttagat cagggattta gtcatattta

1501 ataggagaaa tatggaaaaa tacttctact ctatcttcct ggaagttcct gtttattttt

1561 tatgtccttt tcctctggct agaccgtaag agacttacga aacaaacact tacacattct

1621 actaaactca atgtccaaag tttgtgaact tcttgaatat tgcttgttca tttccacccc

1681 cagtcactga ctgaatctcc ctgctgtctg tctacaatgc caatgagctt ctggttaact

1741 tcttctcatg catgcttagg caacaacttc ccagttttac tacacttgcc catccctagt

1801 tttgttgttg cttaatccct tggcctagtg ccaccatact cctccagcag agcaaccaat

1861 tcttacatta taggacagca catatccact aaaaacagtt catgccacac caaccacatt

1921 tccctttgtc aacaaaatta cttgatagat aattccagga atgcctgatg aagctgattg

1981 acaacaagat atttggcaga ctctctgctg cctatacata ccttagcatg tggaactcaa

2041 gtaatgagag gtccatttaa ttggattgaa ttgggctgga taggattgga ttgaatcctg

2101 tgggatggct aggctaaatt agaaatgaag actagtttaa cagcagtatc caaggatagt

2161 tgactaatga gttaatttta ctctcaaaga cagtctttag tagtaagctg taatgcatta

2221 tatcaaacta ttttccagtc aatgatttat aagttacttg aataaggatg ctaaagatgt

2281 gccttattga aatggcaatt agcacaaagt tgggaatgaa atctaattag ttaaataaca EPI-109 1 107

2341 gaatcacata aaaaaggact tgaataaatg tagcatccta ccatgttcct ggatagaaag 2401 actgctatcg taaagatatt cattctcctc aggttaaatt ataaactcaa tgcaattcaa 2461 caggatttta aaaaactaga caaagtgatt ccaagtttac gtggaaaata aaatgtgagg 2521 gaccaaacaa tatttgaaaa agaaagagaa taaaatctca tccttccaga taccacaatg 2581 tattataaag caatagtaat taacatgagg gcagaaatga gcaagcaagt gaacaaaata 2641 agacagatag tcacaggaaa ctcatatatt tataggtgct ttgcgtataa tgaagatggt 2701 ccttcaaatc agttgggaaa agatgggtta ttcaataaat ggtgttgggt aaaattggtt 2761 atacattggt gagaaataaa gtgaaactcc tactttgtat catatgcaaa aaatagattc 2821 cagacagatg aaatatttaa atgtaaaaaa taaaattcta aaactactag aaaaaaaaga 2881 agaatatttt tattcctttg aaatagaaaa ggtcttacta agcaaaacac agaagtaata 2941 aatgaataaa tgaagacaaa tatgataaaa ataagttaaa aatataagca atctttcttt 3001 gttttttttt cacctttcct agaaaaaaat atataggcaa cttgttaagc aaggtagatt 3061 acaagaaaat atttacaaca tttgacaggc cacagattat tatccagcct catctgataa 3121 gaaaacttca acataaagat atctgttttt tttcttataa ggttcctcaa agtgagccaa 3181 tcacttctta agctgaacaa aaaacaaaac agaagtgatc ttttccaata atgaaaacaa 3241 acattgacag agcagctgta ggatcctttc aggcaaatta tgaaaaggtg ccctttctca 3301 gaaaccacag ttaccattca gctttgtgac cagaggtttg actgtaccct agtccctact 3361 agcaacccaa ccacataacc aacttcaaag gtcctgaatg actgtgttgt acttaatggc 3421 agatgatcta tctcccattt ttgtcctaag gattttccaa gataatatat ttctgcattt 3481 gttttgcttt tacttcactc caaattgaaa tctatttgtg ggataagact aaagaaatgc 3541 ttataggaaa attgatagca ccaaattcct atcttaaaaa atgaaaaagg tttcaaatca 3601 atgacctcag cttttacttt aagaaaatag aaaaagcagg ataagctaaa gccaaagtaa 3661 acagaagaaa ggaaattata aagataagag cagaaatcaa tgaatagaaa acaaaagaaa 3721 aaaatcaaac caaacagctg attctttaag cagatctata aaattgataa aactctagcc 3781 agattgatca agtaaaaaag agagaagaca caaattacca gtattaagaa tgagagaggc 3841 aatatcacta cagatcctac agatataaaa agtataaggg catactttga ataattttat 3901 gactataaat taggcaactt agataaaaca aatttcttga aagacacaaa caaccaaagc 3961 tcacctaaaa tactcacaaa ttgaatagtc ttatagctat tacaaaattg aggccaggcg 4021 cagtggctca agcctttaat cccagcactt tgggagggct aggaaggcgg atcacgaggt 4081 caggagtttg agaccagcct gactaacatg gtgaaaccct gtctctacta aaagtacaaa 4141 aattagccag gcttggtggt gcgtgcctgt aatcccatct actcaggaga ctgaggcagg 4201 agaattgctt gaacctggga ggcaaagttg tggtgagccg agatcgcgcc actgcacttc 4261 agcctgggca acagaacaag actccgtctc aaaaaaaaaa aaaaaaaaaa aaattgaaat 4321 tatagttaaa agtcttccca caaagcaaac tctagaccca gatggcttca atggtaaatt 4381 ctactggaca atcaaacagg aaacagtaat aattctccac aatgtctttc ataaaattga 4441 tgcggaggag atactctcca actcattcta tgaaactagc attaccctga taccaaaatc 4501 atacagagac agtgtaggaa aacaacagat cagtatcctt catgaacata aatgaagtac 4561 aatgcagtct tatgcataaa tcagagcttc attgttctac agataaggta atgtaggatt 4621 gttggttgcc cctccaggtc tgttaaattc acctccttcc ccagagagca tccttcttaa 4681 ggacagggag cctcaatatg tcagtcctca cagcacctcc ctcagtcttc agcacttacc 4741 agctcatcac cacaaccgat accacattgg ataatttcat gaattacttt agagcaaatg 4801 caagagaaaa aatggatttt tatataggag aagaaggagg aaattcttgt ggatttggta 4861 cagaataggg ccaagggaaa attacagatg taaaaagaaa agtgtgtgaa atagtatcct 4921 tagtgctcac aaatacaatg atttcattgt ttttaaaaat aaaaaatgac aaatgtctaa 4981 tgcttggtgg taatgcttta ttgaatgtgt gttatacact ggttcctcat tcctgaagtt 5041 agaaataata ccttcctctt ttcatttggt tatgtttgct gaaacaaatc aaaggctgag 5101 attgaaacac atgctacttc aggtggatga ccttactact aagctcatca caacagcact 5161 tacagctgaa gaccccagag tcctacctaa cttttgtcac aacccagatt ttggccatgt 5221 agttctgggc cttaccatta aagcagacag aagtcagagg aatgactcct ttccacttga 5281 agtgagctgc aggcttctag gaaaggcaag atgcacattt ccctcctgtg gagcataaag 5341 cctttgtaat tcaggactta ggacccatat ggatttgaaa tattatgaca ttggagctgg 5401 agtggttggg gacaacacca gtagtgttat aggccatgga atgtcaaaag aacatggaac 5461 cctgttaaaa tcattaaaca tcaaaactct cccctcctct ggtgatatgg tttggctgtg 5521 tccccatcca aatctcatct tgaactccca tgtgttgtgg gaggcaccca gtgggaggta 5581 attgaatcat gggggcaggt ctttcccatg ctgttttcac gatactgaat aagtctcaca 5641 agatctgatg gttttataaa ggggagcttc cctgcacaag ctctcttctc ttgtctgcca 5701 ccatgtgaga catgcctttc accttccgcc atgattgtga ggcctcccca accatgtgga 5761 acttttaagt tcattaaacc tcttcctttt gtaaattgct cagtctcaaa tatgtcttta 5821 tcagcaacgt gaaaacagac tatctgattt tctgtgggat gtggattatg accatggaca 5881 gagcataact gggacagagc tggaaaaaat attaattagg tgcttaaaaa tatttgttag 5941 aactatcttc atgaatgaga atcaatcctg tttccatggt gattcaccag gcatcaattc 6001 caagcatcca tgaatcagaa aagtcctatc ttctcttagt tatcatccag gactccaagg 6061 aaccataatt agccaacctg ttcacatttc cttttcattc actagcctcg aagtttccag 6121 gggacaggga ctctgtccta ttcatttctg taaccttacc acctgaccca gaatagctgt 6181 tccctgaaga tttggtggat tataaatgtg gatgtcttat ttctttgaaa gtgtgagctt 6241 caggtactga tcacgttatt ccaattatca atttagtatc tttcttcacc attaaactgt 6301 gaaattcttg agggaagaac ctatgactga tttatctctg taaactcatg ccaccagtat 6361 tcaaaatcac acctagcaca tagtaaacac tcaatgtttg ttgaatgact gaaggaatgg 6421 atgaaaatga acctccttgc ttctgaccag tggatgagtt gcttggccgt gttcctacag 6481 cctagagctc atcccctaaa gcatctgaag ttacccatta gtgcaatggt tcttgaacgc 6541 tggtgttgat cagaatcatc tggatgccca ggttctctga aataagatag ggtctaggca 6601 tttgtatttt taccaaggag gtgtgatgga gtcagatgca agaaggctag ttgaagaaac 6661 cacatgagag tttagtgtag tgtattagaa gactggtttg gctctgtcgc tagtggctac 6721 atcatcttgc tcaagtcatg ccagtctcag gacctcattc agtctcttca gctgtaatat 6781 gggtgggttg caccacataa ccagaaagat cccttccagc tctacccact tacaacatgg EPI-109 1108

6841 tcaaatttgg tctgattttt taaatcgtag tacaatatat atgacataaa attcaccatt

6901 ttagccactt taaatgtaca attctgtagc attaactaca ttcacattgt tgtgcaacca

6961 tcactaccgt ctacttccag aactcttcat cttgcaaaac tgaacctctg ttgtcattag

7021 tcactaacta ttcctctccc cccctccttc taggccctgg caatcaccat tctactttct

7081 gtcgctatga atttgactac tctaggtaac ttatataagt ggaatcacag catttgccct

7141 attatgactg gtttagttga cttagcacaa cctcctaagg ctcaaccaca ttttagcatg

7201 tgtcagaatt ttctttgttt ttaaggctga ataatattct gttgtatctg taaataacat

7261 ctttattcat ttgtccatca acagactgtt gagttcctcc catcttttga ctattgtgaa

7321 aaatgctgct atgaacctga gtgtacagac atctggttga gtactgcttt caattcattg

7381 tttatatgga tcatatggta attttatgtt taattttttt ggaactgcta cattgttttc

7441 cacagtgtac atcattttac atttccatca gcaatgcaca aaggttccaa tttctccaca

7501 ttcttaccaa cattttttat tttctgtttc ttatttattt gtttatttat tctgagacag

7561 agtctcactc tgtcacctag gctggagtgc agcagggtga tctcagctca ctgcaacctc

7621 tgcctcccat gttcaagtga ttctcctccc tcagcctccc aagtaaatgg aattacaggt

7681 gcccaccacc acgcccaggt aatttttgca ttttttttag tagtgatgag gtttcaccat

7741 gttggtcagg ctggtcttga actcctgacc tcaagtgatc cacccgcctc agcctcccaa

7801 agtgctggga ttacaggtat gaaccactgc acccaggcca ttttttgctt tttagataat

7861 agtcatccta gtgggtatga agtggtattt cattgtggtt ttgatttata tttccctaat

7921 gatcagtgat attgagcatc tttcaagtgc ttattggcca ttttcttctt tggagaaatg

7981 tctatgcaag tcctttgctc attttttaat ccagttgctt tttgttattc tttttgattt

8041 gaaagtgttc tttatacctc ttgtatacta atcccttatc agatatgatt tataaatatt

8101 ttcttctttt ccatggattg ccctttttac tctgttgata gtgttctttg atacaaaata

8161 atttttaatt tgaatgaagc ccaattaatc tatttttgtt tcttttgttg cctgtgcttt

8221 tggtgtccta tccaagaaac tgttgccaaa tccaatgtca taaagctttt tcccatgctt

8281 ccttctaaga gttttgtagt tacagctctt gtatttaggt atttgactat tttgagttaa

8341 tttttgtaca tcgtataaaa taagaatcca atttttattt tattttactt tttgtatgtg

8401 gatatccaat ttccccacca ccattcattg aaaagactgt ccttttccta tcgaatggtc

8461 ttggcaccct tgtaaaacat aatttgacca tatatgtgag ggtttatttc tgggctctct

8521 attctattct attctattct attctattct attctattct attctattct attctattct

8581 attggtccct atgtctttct ttattctagt accaccattt tgctcatcat aactttgtag

8641 taagttttga agtcaggaat cgtaagacct ccagctttgt tcattttcaa ggttgttttg

8701 attattcaag gtcccttgat agtccatatg aatttcagga tggatttttc tatttctgca

8761 aaaaaaaaaa aaaaaaaaaa aaaaatcatt gaaattttta aacagattgc attaaatctg

8821 tagattgttt tgggtagtat tgacatttaa caacattaaa tcttccaatc aatgaactag

8881 gctattttta tttatttttt ctgtttcttt gagctacttt tgtagttttc agtgtataag

8941 tttttgctac ctggttaggt atacttctaa gtattttcta ctttttgatg ctattgcaca

9001 ttgaatcgtt ttcttaattt ggtggtagcg gggattgtgc attgttagta cataaaaatg

9061 caactcattt tttgtgtgtt gattttgtat cctgcagctt taacaaattc atgttagttc

9121 taacagactt attctatgaa tcattagggt tttctacata aaagatcatg tcacctacaa

9181 acagagataa ttttactcca ccccttcccg ttgcaatgcc ttttatgtct ttttcttgcc

9241 taattgttct ggctaagact tccactacca tgttgaatag aagtggtgaa agtagacatc

9301 cttgtcttgt tccaatctta gagccaaagc tttcagtctt tcacggcctg aaagactttg

9361 taatatgttc tcaaggttaa agaacttcag aagttttcta agcaagagac cattttatta

9421 acttagttgg cagcaattct gagagattag aatgaaaaga tagaggataa gaagtatctg

9481 gcaggtataa tatattgagt gtgctgaata tacttttagt tttgtatagg tgttaaaaaa

9541 tggcaaagga ggccgggcgt ggtggctcac gcctgtaatc ccagcacttt gggaggccga

9601 ggcgggcaga tcatgaggtc aggagatcga gaccatcctg gctaaaacag tgaaacccta

9661 tctctactaa aaatacaaaa aactcgctgg gcatggtggt ggacacctgt agtcccagct

9721 actcgggagg ctgaggcagg agaatggtgt gaacctggaa ggtggagctt gcagtgagcc

9781 gagatcacgc cactgcactc cagcctgggc gacagagaga gactccgtct caaaagaaaa

9841 aaaaaatggc aaaggaaaga atgaaaaata aagcaaggtc ccagaagagg ccaaaaatct

9901 taatcaaaat tgactgaaca ttacggaatg aaatggtttt tcctttactc caattaacga

9961 cttcacaaga agattccatc ctcgtttata agattaaccc aaaaccagca cttaaaacca

10021 gaagccttga aaggatggag tttggggacc cttctcatgt ctattcccag aagggggtct

10081 tcttctgggg tcctgtcccc taaagagcta ggcaaaaagt atgcttgcca catctgttga

10141 aagatagaaa gttggtctaa aaatacatga gagggaactg aaacatttca gagaaggcaa

10201 gactcagaag taagaaacca aaagaggaag gtaaaattct agttacaaag aaaagaggaa

10261 tggaaattaa attgtcttac agagaaaatc cagaactgcc ccctcttccc ttactactcc

10321 atcaaaaaag gggaaaaata gtcaatggga aagttttgag aaaaatagat ctctgcattc

10381 ttctggttga gaattcagac aacttgaact agagagctgg gtaatttctt gactaaaggt

10441 gtgttagatc tgaaagggtt tttcttaaaa ttgtctgtgt tcatccctcc catcttagag

10501 aggaacacag gataagagac ctctggagct cccccagggt caccgagcta ataggatcag

10561 agacaaagct acaaagtcat tttctgacat ctctccaggg ctcttttttt ctggaccccc

10621 catatcaaca tgatgtattt attacattgg attagcaact ctccttgagc tttcctcagt

10681 accaggttta catctcagtc tgtgggtctc agagaaagta cccaatcagc agcaacatta

10741 cctggaaact catcagaagt gcccctcctc agccccaccc cagatctatg caatcagaaa

10801 ctctggaaat gcaggccagt cctaacaagc ccaccaggga attctggtgc actaaggttt

10861 gagatccact gatcaaagaa ataatattcc ttttcttcat tataatagca tgaataataa

10921 ctaacatgta tttcacaatt tacaaaagag ctttatgctc ttgttaaatt tgagggtagt

10981 cttctcaaaa tctctgtgag gctagaaagt cagatattga aacacctgtt ttatgggttc

11041 aaagataggt tcaaaagaga gtaaatgatt gttggggtgg caggtccaga gagggcagga

11101 tcaaaactgc aattgagtct tctgccttat aaaccagcat agcttcccca aggcacgtca

11161 cttctcgata aaatggtgac aactagagtg tcctttcaga tcattcttag aagcatggag

11221 tgctaggtca attgtgtaat tgatgaggaa ataataatac taagaactcc catcttctac

11281 gtccttatat acaatcctgt caggtagaag ctgagtctca gagagaacaa gttgccctcc EPI-109 1109

11341 caggaccacc aggtaagctc ggcatagctg tgcttagaat gtaggctgtc tggcttctgg

11401 gcttgcctgc ccagggaggc tttgtgggtt ctacttggtc atccagatca cagaggggca

11461 gcactgactc ctacccagtg ctcttgactg tacatctaat actttctact aagaaaaccc

11521 cttctcttta gaccaatggt tttcaaatct tggtgtgcat tggaatcacc tggaaagctt

11581 gttaaaacac agattgtccc accccaagag tttctgattc tgtaggctgg ggtggggacc

11641 catgaaagtg catttctaat aaggtcccaa gtgatgctga tgccaccagt gtgtggacaa

11701 ccctttgagt ggtgaagctc tggacaccct aatttgcaag gctaatcagg catatgtggc

11761 aaatgaatac gaactgaaat tctgactcca atatcttcac tgatattcct aatccatagc

11821 atacacacag tcccattcgt ttccctttta gcttttaatc tacatttatc ctttcttcct

11881 ctgccactgc cttctctcca gttagctcaa accaggtaac acataaccgc ctcctaactc

11941 atccgcccag ttggtttctt tggctttaat ctagacttct tatctccacc agatttgcct

12001 taccaaagca ccaatttctt aaggcagggt tagaattaaa aatcttctgt tcctcctcat

12061 tgcctaaaac tcctaaactt atgattcaag gtcttccatg accttcatgg accagtctaa

12121 cgttttagcc tgtcctaagt gacatgcctc caccacatac ttcatgcttt ccactttctt

12181 tctccatgtc tttgttcatg catttccatt tcttctacct gcgatgtcct ccttcgccat

12241 ctctgtagat ttaaaaatcc tacagggctc atctcaaatg ccctttcctt catgaagcct

12301 ttcatgaaat ccccatcgag aggttttccc tcctctcagc tctccaaagc acagatgtct

12361 gcgtttgtgg ctattatctt acgttgtttt gtattaaaat ttctccagct ttacacattt

12421 gtcatcctct taaggacaaa catcttatta tggtcaatgt gaagctatag aggataattt

12481 aatgaaatat tccaagggct agtcattaca catgactgat ttatctctgt aaactcatcc

12541 acactcatcc acctgatttt gattggccaa gttaatgaat cagagaggaa aagatggtaa

12601 aaatataata aaaatctcct aggtagtctc acatcccaca gagccccagg taatgaaatg

12661 aggccctgag ataatacttt atgaacaata aaactccggg ttctattgac agtgaagcaa

12721 gacctgagag agaaggctaa attcccttgt gtctagctgc cacaatcttc tgagaataat

12781 ggcctttctt cccgtctgcc ttctgaatca taggcaaatt tttctctttg gtgatcccta

12841 atacagaaag gggaagtcaa ataaaatata tacaaggaga aggattctgg gagacagagt

12901 ttcttgattc ccttctgcat gctcctcctc aaaagccttt atgagcttac cttacattta

12961 aattctttta aacaaggcat tatgtggtct ggtcttttcc agctccacac accttcacac

13021 tacattcccc ccagctaatt ctgctctggg aacactgacc ttcttttagt tctttgaaca

13081 cattgatttc tggtcaagat gactcagtaa cttcaacctt tgttgtgccc ttggtgctgt

13141 gaagatatag atatatatta accactgcac accagaaatc agaaatagca caacagagaa

13201 taaagtcatt gagccatctt ctgagctcca aaagacaaat tttctccaaa aagacaaatt

13261 caggctctaa aacaatacct taaggaacca gaagtggaat agaaaattaa ggtggtaagc

13321 agggctaaac cacatgcctg ttgagcccag gtttggaaga agacaatggc aggtaggaat

13381 gtggtttctg atgggtaata ggtactgttt tcatttactt tctgttgctt ataacagaat

13441 atctgaaact gggtgcttta taaagaaaag gaatttatgt cttgcagtta gggaaactga

13501 gaagtcaaaa gttgagggct gcaattgaca agtgccttct tgctggtggg gatactctga

13561 agagtcttga ggtggtatcg ggcataccac tctcagtgag gggactgagc atactaggtc

13621 aggtctttct tcctcctttt ataaagctat cagtcccact cttatgataa cccattaatc

13681 cattaactga ttagccaatt aatccatgaa tggattaatt cattcatgag ggcagagcct

13741 tcctgaccca aacacctctt aaagactcca cctctcaata ctgccacatg ggggattaaa

13801 tttcagcatg agtttttgat gagacaaata ttccaatgat agcagttatt aaaagtacat

13861 gcttgagaga aggggattgg agtcagcctc agtgcttaaa ctcaaaagct aggatgaggc

13921 tctaacactc ctgaaagaag gagttgctgc tggctcctta ccagggctat atcttttaca

13981 gagcaggaga cctaaagagg caggaggacc cggacatcgt ttggaaacca agcactaaaa

14041 caggccatct gttatacccc caatatcctc tcaggacaag tgttttgaac cactcacaca

14101 aggactagtc tgggcaagtg ggctagatga agaaaccaca aaatagctaa gtggggagag

14161 aaagaccaaa aatactattt tattcaaaat gaaaatacaa tccaaaattc catgattcat

14221 gaagaaatca aatggtatgt gttaggtggt tcttgcattg ctatagagaa atacctgaga

14281 ttgggtaatt tataaagaaa agaagtttaa ttggctcata attctgcagg cttcacagga

14341 agcatggtgc tggcatctgc tcagcttctg gagaggcccc aagaagattt gctcaaggca

14401 gaaggttaag ggagagctgg cacatcacat ggtgagaaag gaagctagag agagagtgca

14461 gggtgaggtg ccacaagtta ccacagccag atctcttgag aactcactta ctttcatgag

14521 gacagcacca agccataagg tgtagggagc caaagtccca tgggacatga ccaactcagc

14581 attccactgg aggctatatg atcaaacagc aaactgttta tcacgaatgc aggatgtgag

14641 caaactcaca actggtcctg ccaacagaag gtttgttgga ggcaatcact ccctggtgcc

14701 tgaggtaatc tactgcaaca tctagagaat gcagtcttgc aagcctactc tggacagggc

14761 agctggcacc ttattccatc ccccttctca ctatcttttt ttgcctaata aatacagagg

14821 gctgtgtaaa gctcagggcc cttgtccact agaggcaagt tgccccctga ccccttcttc

14881 caaatatact cttttgtctc ttgtctttta ttctcacatt tgcccccttt gttcagttcc

14941 actaggtccg tgcgggttat atactggtgc cctgagcagc aacagaatca ggctctcaac

15001 aagtgtcatc cgaacatggg actttgagga catgaacgaa gaaggtctgc tggagcagag

15061 gaacagaaat tgacaaggtg aacagggacc ctgggacgag tctgccagca gcggatataa

15121 ggtcagttac ctaaagaggt actgatcagt gccctaaaga gatactggga gcagtgcttt

15181 aaagaagtac tgggaatggg aaattttctg aatcagggta acaaggggaa gaatttgtct

15241 attaaagaaa aacattatgt gcagttgctt aaagttgtat tggaacagtc tggagcttag

15301 gttaatttgc agacactaac tatcacatgc gtccgtgtga agagagtcca ccaacaggct

15361 ttgtgtgggc aataaagctt tttaatcacc ttggtgcagg tgggctgagt ccaaaaaagg

15421 agtcagcaaa gggagataga ggtggggcag ttttatagga tttgggtagg tagtggaaag

15481 ttacagttaa aagtggttat ctcttgtggg cagaggcagg ggtcacaagg tgctgggtgg

15541 ggaaatcatg agactctttt tctgggacag gagtgtcaca aggtcaattg atcagttggg

15601 gtggggcagg aacaaatcgc aatggtggaa tgtcatcact taaggcagga actgactatt

15661 tcacttcttt tgtggttctt cagttgtttc gggccatctg gatgtatagt gcagctcaca

15721 ggggatatga tggcttaggt tgggctcaga gacctgacat tcctatcttt ttatattaat

15781 aagaaaaaca aaacaaaata gtggttaagt gttggggcag caaaaatttt ttggggtggt EPI-109 1 1 10

15841 atgtagagat aaggggcaat gtttctcagg gctgcttcaa gcacgatcac ggtggtgtgg 15901 gaatctagag tgggaga at taagctgaag aaaaattttg gggaaagggg tgatattctg 15961 gggttgttag aaggagcatt tgtcatatag aatgatgatg gcctggatgt ggttttgtat 16021 gaattgagaa actaaacgga agacacaagg tccaaataag agaaggagaa aaacaggcat 16081 taaaggatta agaattagga ggacacagga catccaatta gagagtgccc aagggggtcc 16141 agtgtaatta tttgcctgga caatgagttt tggggctcta ttaggttgtc atataccagg 16201 ccagattgat ttaggtaaaa acaacactct tcatttaaaa tatacagagt cctccttttt 16261 tagcagtgag taagttgaga cctattcctg tcttcttata ttaataagta aaataaagca 16321 aaatagaggt gaagtgt gg tgtcatgagg ggaacaggaa gcagttcggt cctatttgca 16381 aattgatttt gggggggtaa agaaaactag tgtacctttg cctgtccaat taataagtag 16441 acacatgtag atggaggagc cacagaggaa gaagagaact ttgtaaggca aaactggaaa 16501 tgtaaaggga aaagatgaga gggagcacca aaagaggtgt cttgcaccca gactcaggga 16561 tctagtgaga gcagcagctg ttagaggttg taatggggat taatggggct actgggtaga 16621 gggggaggtt caacttttat ggtgtatgag aaagcgcata gtgtctacaa gcaacctttc 16681 attgctattc ataggattgg gtataagtaa acaagaaggg ggggctagga ggagagtctg 16741 aagaacaagg ggaaggtagc caaggatgga gtgaaatgta gggcaaatgt cttaaaggaa 16801 atgagaggtt ctaagaggag ggctagtggc ttgtaaccca catggaagag gttacgaaag 16861 gatgatagaa tggaatgagc ctgtgaggct ggaaggagga attttccttg gtccaagaac 16921 catttgcctt gtgtgggaag agtttgatag gtggaagttt cagtgggagg gtaggcggga 16981 gtgactgatg agaaggagaa aaactggcca taagggacag aagttggaat gctagctgct 17041 cctttagcta ccttatcagc ataagctttg ccctgagtga tgggatctga tgccttttga 17101 tggcgcttgc agtgaatgac cctagcttcc ttggaagtag agcagcttta agaagagttt 17161 ttatgaagaa ggcattaata atggaggacc ctcgtatagt gaggaaacct ctttcaggcc 17221 atataacaga atggaggtgg agaatatgga aggcatattt agagtcagta taaatactga 17281 cacacaatcc ttttgcaaga gtgagggctc gagttaaggc aatgagttcg gcttgctgag 17341 agggagtgga gtggggcaga gtggtagcct caatgataga tgtgaaagat actatagcgt 17401 agcctgcctt tgctggtgag tggtgattag gcctagtgga actgccatca ataaaccaag 17461 tgtgatcaga gtgaggaaca ggaaagaagg aaatatggga aaatggagtg aatgctaggt 17521 ggatcagaga gatacagtca tggggatcag gtgtggtatc aggaataatg tgggaggcca 17581 gattgaagtc caggccagga acaatggtaa ttgtgggaga ctcaacaaag agtgagttca 17641 actgaaggag ccgggggagg gggagagcgg cagaaagtat atgcatcagg tgtgaggaag 17701 aaaatacatt ttgaaagtta tgagaactgt agagagtgag ttgatcatag tttgtgattt 17761 tgagggcctt taaaagtatt aaagcagtgg cagctgccac acacagacat gagagccagc 17821 ctaaaacagt aaggtcaatc tgtttagaca gaaaggctgc agggcactgt ccaagctctt 17881 gtgtaaggat tctgaccgca cagccttgta ctttggctgt gtgtaatgaa aagggttggg 17941 atgagttagg gagagctagt gtgggagtag cttctagggc tgtttttaag gaacataaag 18001 aggagtgggg aaaggattta ggatctatgg ggtcagctag gtttcctttt gtgagtttat 18061 gtaatggttt agtcaggatg gcaaaaccag gtatccaaag gtgaaagtac ccaaccatgt 18121 ctaggaagga aaggatttgt tgctttgtag aagggattgg ggtttgggag attagccgga 18181 cacagatcag gagggagagc acttgtattt ttatgaagaa ttatgccgat aggtaacgga 18241 tgaggaagaa atttgggctt tggaggggga tacacgatat tcccttgaga atagatgttg 18301 gaggagcagg agggtgtcct gttgggaaga ttcataggag gggctataaa gtagaaggcc 18361 atcaaaatat tgaataaggt gacaagcaga tggacagaaa agtaaattat gagaaagggc 18421 ttgactgaag taatggaggc tgtccctgaa gccttgtggc agtacagccc aggtaagttg 18481 ctgagactga tgggtgtcag ggtcagtcca agtgtaagtg aagagaggct ggggtgaaga 18541 gtgcaaagga atagtaaaga aagcatcttc aagatccaga acagaataat gggttgtgga 18601 gggaggtatt gaggatagga gagtatatgg gtttggcacc acagagtgga taggcaagac 18661 aatttggttg ataagctgaa gatcctggac aggctttagt cccttcaaag cctgttgtgg 18721 gatgggatac tggcattgag caggataagg gtaattaggt tttaatggga tggtagggtt 18781 gcgtgatcgg tcaccaagga gggagtagag gtatcccata cttgtgggtt aagataggga 18841 gtcaggaggg gaggttgtga aggaggcttt gaactgggga aaagggtggc aatgaggtgt 18901 ggctgtagcc caggaatagt cagggaagca gataatttag ttaaaatgtc tcaatttaat 18961 aagggagctg ggcaggtggg aataactaaa aaggagtgca taaaagaatg ttgtccaagt 19021 tggcaccaga gttggggagt tttaagaggt ttagcagcct gaccatcaat aaccacaaca 19081 gttatggagg caagggaaac aggcccttga aaggaaagta atatggagtg ggtagcctcc 19141 atattgatta agaaagggac agacttaccc tccactgtaa gagttaccca aagtgtctgt 19201 gatgatccag gaggcttctg aggtgatcag gcagtgtcag tcttcagctg ctaagctgag 19261 aagatctggg aaggagtcag tcagagagcc ctgggccaga gttccagggg ctctgggagt 19321 ggctgacggg caagttggac agtccgattt ccaatgcggt cccacacaga tgggatacag 19381 tttaggagga atcctgggct gtaggcattc cttggcccag tggccagatt tctagcactt 19441 gaagcaagat cctggaggaa tgcctgacca cagtggttta ggtgttttga agttcttgtg 19501 tgctggagat gtggctgagg tttttctcac agcagaggca agtaattgca actcagaaat 19561 acattgccac ttggctgtct cttctctatt attgtacacc ttgaaggtga ggttaattaa 19621 gtcctgttgt ggggtttgag ggccataatc taatttttga agctttttta atgttgggag 19681 tggattgggt aataaaatgc atattgagag taagacagcc ttctggcccc tctgaaccta 19741 gggcagtaaa atgtctaaga gttgttgcca aagggaccat ggactgggct gcgttttcat 19801 atttgatgaa aaaaaaagag cctaaatgct aactaatttg ggagaggtca gataaagtaa 19861 aaggaacatt aatcttgact atgccttcag ctcttgccac ctctctaaga ggaaattgtt 19921 gggcaagtgg aggagtgcta gtcgtggaat gaaaccataa gctggactgg gtgtgaggag 19981 gggaggtgat agaaggatta cagcgtaggg gagtagaggc tgaggaagaa ttgggacctg 20041 gctcagcctg gtgaggagtg gcctggtgag gagcagcctg gggaggagga gagaggttag 20101 atgggttcgt agaaaagaag gattcaaagg actcggagct tggtgaggag actgaaggaa 20161 cagacaggag agaaagaaga aagatttggg acaagtcgca ttgggagcag agactaggaa 20221 gggagtgatg tgtaaagaat gcctggacat caggcacctc agaccatttg cccattttat 20281 gacaaaaatt atctaagtct tgtagggtgg agaaatcaaa agtgccattt tctggccatt EPI-109 1 1 1 1

20341 tggaacaatt atcgagtttg tattggggcc aaatggtgtt gcagaagaaa ataagatgct 20401 taggttttag gtcaggtgag agttgaagag gttttaggtt ttttagaaca caggctaagg 20461 cagaagaagg aggaatggag ggtggaaggc tgcccataat aaaaaggtaa gtttagagaa 20521 aagagaggat agagacacag agagaggggg tggtggtact catcagccag gggaggtggt 20581 acttgccacc aaggtgatgg atcaaggcag tcatccccac ggtgatcaga cacctctgaa 20641 atgtgggtga ataatcaggc aggtgtccct gcagtgatta gacaccaagg ggagactgtc 20701 ttcccgagtc cgtgaccggt gctggagttt tgagttcaca gataaaacac atctcctctg 20761 tctctaccag aaagggaaag gaactgaaat taaggaaggg agagattgaa gggtggagag 20821 atagcaagag agttggaaaa gagaataaaa agaggccact tactcaattt aaaattggtg 20881 agatgttcct tgggctgatc tgaggaccca aggttgtagg tggatctcct cacggaatga 20941 gggtgaggac aggggactgg tctccagaag gagttcccga gtcctggatc ttcagcacca 21001 aatgtcatgt gcatccatgt gaagagagtc caccaacagg ctttgtgtta tcaataaagc 21061 tttttaatca ccttggtgca ggtgggctga gtctgaaaaa ggagtcagca aagagagata 21121 ggggtgggtc agttttataa gatttgggta ggtagtggaa agttacagtt agaggtggtt 21181 atctcttgag ggcagaggtg ggggtcacaa ggtgctgggt ggggaaatcc tgagacttat 21241 catccaggga aggagtgtca caaggtcgat tgatcagttg gggtggggca ggaacaaatc 21301 gcatggtgga atgtcatcag ttaaggcagg aactcactat ttcacttctt ttgtggttct 21361 tcagtttctt caggccatct ggatgtacac gtgaaggtta cggggatata tgatggctta 21421 gcttgggctc agaggcctga cactaacctc ctgcagaagc cacaaaaggt tattacacat 21481 aaaccatggt ttccacaggc aggcactctt gatgtggaaa attgggatag agcaggatta 21541 aaacaagctc atcaaaaagg tcttaaagtt gattcttcag ttttctccac ttggagttta 21601 gttcatactg tacttctgcc attatctcct tattattctg cggaacagca ggctgaatct 21661 aaaaattgga aagaatttgt tgtcctactc acagctccaa ttgaatataa aaaacaggag 21721 agggaggata aaaattggcc tataccgcct cctccagatg cagaaacatc tgtaccatct 21781 ccttcagtgg cagaaataga gatcccagta caaagaattt tatgctctgc tgtcatagct 21841 ggagagccct taggaccttg tgcttttcct atttctgtaa ggcctgatcc aaataatcca 21901 cagcagttta ttcatgaaca ctctccacta gaatttaagt tgttgaagga attaaaaact 21961 agtgtggtca ataatggagt acaaagccaa tggttcctgg aggaaggaat gctagacata 22021 gaactttggg agcaagtggg gagaaatctt aaacaacacc aggcacaaag gcatcaggtc 22081 ccagtaaaat cttttatgtt aggggctttg agtagagcag ccctggttgt tacacacaaa 22141 agagcctaaa aagggaaagg aggaggaaat gtcacctgcc ttatcacctc cccttccctc 22201 agtgccaata tcactgggcc aaaataacaa agaggaaatg gaggtcttac ctaagcttcc 22261 tcctccaata gataggaaga aggacagagg atacgctaca gctatcagtc cctgtcttaa 22321 gcaggcagca ttagaaggag agctcttagc cgggtgcagt ggctcatgcc tataatccca 22381 gcactttggg aggccgaggc aggcagatca tgaggtcagg agatccagac catcctagct 22441 aacatggtga aaccccgtct ccactaaaaa tacaaaaaat tagccaggca tgttggtggg 22501 cacctgtagc cccagctact tgggaggctg aggcaggaga atggcatgaa cccaggaggt 22561 ggagcttgga gctttcagtg acctgagatt gcaccactgc actacagcct gggcaacaga 22621 gcaagactcc atctaaaaaa agaagaagaa ggagagctct taacctgctc agtaatgcaa 22681 aatcggcaag gcaatcaggt gtatgtttat aaaaagataa gaaaaaggca ttagaagcca 22741 aaaccacgtg gccaagcagg cagtgggcag gagaaaatgc tcagaggcag aaaagctcac 22801 agcgacaaag ccaacaaggt ctgcccagga cggcagcatc cctctggcaa aggagcaagg 22861 gagcagcaca gacacaggca aagcctaaac aagtacaatg tggccacctc ccaggacctg 22921 caccactgcc ctctggctct gtgggcagcc cattgcaaaa tttcatgtgt tacatctcag 22981 gctatgattc tctgctaaga tgtaagtaaa atgtaagaat ttgaaaagca tcttttctaa 23041 taatggccac tattgtcatc tctctcctat ccctgatgta gctttccaaa ttcaatttaa 23101 gtaaaacagt aacctttgaa gggaaagaga ttacagaggg cccatgaatt agttgaagag 23161 taattaaaag ctaggcatgt aaaaccacac attacgcttt aaagaagaaa tttaaaccta 23221 attaaatgat atttgttaaa ttagaaggta aaaatgttgt gccctgttgg gaacaggccc 23281 ccaaatctgg ccataaactg gccccaaaac aggccataaa caaaatctct gcagcaccat 23341 gacatgtttg tgatggccat gatgcccacc ttgaaggttg ttggtttact ggaatgaggg 23401 caaggaacac ctggcccacc cagggcagaa aattccttaa aggcattccc aaaccactaa 23461 tgatagcatg agcaatctgt gccttaagga catgttcctg ctgcagacag ctagccagag 23521 cccatccctt tgttttggcc catccctttg tttcccataa ggaatgcttt cagttaatct 23581 atgatctata gaaacgatgc ttatcactgg cttgctgtca ataaatatgg gagtaaaact 23641 ctgttcaggg ctttcagctc agaaagccat aagccccctg atttcccact tcccaccctt 23701 tatttctgtg tgtgtgtctt gaattcctct agcgcctctg ggttatggtc tccacaacca 23761 cgctggtctt ggcagtgccc ttctcagaaa gtgaaaaaga gttgtatgta agtgtagtga 23821 aaacataagc atgaatcact gtcttaaccc actgattaga tagtctttga tttgtacttg 23881 ctaaaagagt cctaaattga gttcctcagc tagtgagtca ctgttttcaa gactgtttgc 23941 cagattgaag tccataaact tggtcagccc gaaaactcaa ttacaagatc taagctattc 24001 tgcctgtggc tttaagcaca tggttaaagt atattattta agtctctcct tctagatatg 24061 ctttcagatt ttctttttaa acttcttgtt acttatttca gctttccata ttgataatta 24121 atgcagtcaa ttgctcagtt atgactgtga tatcatcagg attcctttaa gtaaaaggca 24181 attcaaagcg gtattgcact cccccatacc taatgcttta acactgttta ctgatgggtc 24241 tggtaaacat ggaaaagctg cagtctagta gagaccacat aattcaatca ctcgatctga 24301 gttcactagc actcagagag ctaaggttac tctgtttatt tattaaagaa tttttacaac 24361 cttaagctca ctctggactt tccagcctta tgtggcaaat gtagccatca atttatgggg 24421 tcaagactta cttacagcat gggatatgag gcttacaaat gagactttga taacccagga 24481 ttttaaatgt tgaagaacac gggatatcag agtgaaaaag gtttagggaa aattctgaca 24541 agggaaaatt ctaacctgat atcaataact ggaaagacag gttaaaccct gcaaggggat 24601 acattgacat tttttcttcc tcacttgctc ttttctgctg tctgaatatg ggcatgaggg 24661 caagagtcat tttagaccac caagtgacct tgaggataga agccttatac tagaggtggt 24721 gggaaagaaa aaacagaagg actcataaag aaaaaaataa taaacctcag tattaagatg 24781 gaaaaattcc cccaattggt ctataggttg aacttcatct ctattaaatt tcagctatgt EPI-109 1112

24841 ttttgcagaa tttgatatgc tgatcataaa atttatatga aaatgcaaga gacacagaat

24901 agtcaaaact ttgaaaagaa gaaagttgga ggacttacac ttgttgattt taaggctttt

24961 tacaaagcta taataatcaa gacaatgtgt tactgacata atgatagaca tattgatcaa

25021 tatagacaat ggatgaatgg agtagaattg acagtctaga aataaaacct tatatatatg

25081 gtcaatttat ttctttatgt attctgtcat ccagaataca taaagaacac cttcaactca

25141 ataacaacaa taccaacaag ggtgccaaga ccaatcaatg gaggaaataa tagtcttttc

25201 aagaaatttt gctgagacaa ctaagtattt atatgcaaaa taatgagttt gaatggctac

25261 catatacaaa aattaactca aatggactat attaggtcag tgcaacagta attgcagttt

25321 accaccatta cttgtttttt ttttttggtt tttttttttg agacagagtc ttgctctgtc

25381 acccagacca gagtgcagtg gcatgatctc agctcactgc aagctccact tcctgagttc

25441 acgccattct ccttcctcag cctcctgagt agctgggact acaggcatct gggtaatttt

25501 tttgtatttt tagtggagat ggagtttcac catgttagcc aggatggtct caatctcttg

25561 acctcgtgat ctgcccacct cagcctccca aagtgctggg attacaggca tgagccacca

25621 cgcctggcct accattactt ttaatggcaa aaatgcagtt acttttgcac caccctaata

25681 gaactaaatg taagagctaa aactacaaaa ctgttagaag aaagcatagg agcaaatctt

25741 aatgacatga gagttggcaa ttgtttttta gatatgacac caaaagcatc aaggacaaaa

25801 gaaaaaaatg gataaattgg acttcctcca aattaagaga acttttgtcc tgcaagcaat

25861 actattaaga aagtgaaaag acaagtcaca aaatgggaga acatttttgc acataatata

25921 tttaataata ggctgacatc cagaatacat aaatacctac aactcaatac caaaaagaca

25981 gcccaattta aaaatgggcc aaggatatga ataaacattt ctctaaagaa gatacaaaaa

26041 tggtcaatat gcacatgaaa agatgctcaa tatcaatatc tattaggaaa atacaaatta

26101 aaacacaaaa tataaaacac aagatatcaa tttacactca ccaggatggc tgttatcaaa

26161 aagacagata acaagtattg gcaaggattt ggggaaattg taaccttcat acattgctgg

26221 taggaatata aaatttgcag caggtttgga aaacagttta gcagtttctc aaaaagcctg

26281 ggcatggtgg ctcatgccta caatcccagt gctttaggga gctgaggtga gaggattgct

26341 tgagcccagg agttggagac cagcctgagt aacacagtga gacctctttt ctaccaaaaa

26401 gaagagagtt aaacataggg taccatataa gccagcaatc catctcctag atatgtaccc

26461 aagaaagttg aaaacatata ctgacacaaa aacttacata tgaatcttca tattagcctt

26521 ataataatag ccaaaaagta gaaacaaccc aaatacccat caactaatta aaatatggtg

26581 tatctataca tattatttgg ccataaaagg aagtactgat acatgtcata acacaaatga

26641 accttggaag cactatgatc tctgtattag tcagctcttg tattgctata aagaactacc

26701 tgagactggg taacttataa agaaaaaggc ttaattgagt cacagttcca caggctgcac

26761 agggatcatg gcccaggaga cctcaggaaa cacagttatg atggaaggaa gagagtgaag

26821 gaggaggtgc tacatacttt taaaccacca gatcttgtga gaagtcactc actatcatga

26881 gaacagcaag ggagaagtcc acccccatga tccagtcagc cccagccagg ccccaactcc

26941 aatattgggg attacaattc cacatgagat ttgggtgggg acactaatcc aaacaatatc

27001 attctgcccc agcccctccc aaatcctgtg tccttctcac attggaagat acaatcatcc

27061 cttctcaaca gtttcatttc agtattaact caaaaatcca aagtctcatc tgagacaaga

27121 caagtccctt ccacctatga gcctataaga tcaaaaagaa gttagttact tccaagatac

27181 aatggaggta caggcattgg gcaaatatat ccattccaaa agggaaaaat tagccaaaac

27241 aaaggggcca caggccccac gcaagtccaa aatcaagcag ggaaatcatt aaatcttaaa

27301 gcttcaaaat gatatccttt gactccatgt ctcacatcca ggccacacca atgcaaggag

27361 tgtgctccca aggccttggg cagctctacc ctgttgctct acagggtata gcccccatgg

27421 ctgctttcac aggctggcat tgagtgcctc cagcttttcc aggtacacag tgcaagctgt

27481 tagtggatct accattctag ggtctggaag attgtggccc tcttctcata gctccagtag

27541 acagtgcccc agtggggaat ctgtatgggg gctgcaaccc cacatttctc ctctgcactg

27601 cccaatagag gttctccatg agggctccat tcctgtagca tacttctacc tggacatcca

27661 ggtgttttca tacatcctct aaaatctagg taggggctcc caagccttaa ctcttgccct

27721 ctgcacatcc gcaggcttaa taccacatgg aaaccaccaa tgcttatggc ttgcacccta

27781 tgaagcagta gtctgagaca tatctgggcc cttttggcca tggctgggat gcagggaaca

27841 gtgtcctgaa gtggcacagg gcagcggggc catgggcctg gcccatgaaa ccttctttcc

27901 tcctaggcct ccagacctgt gatgggaggg tctgcctcga cggtctctag aatgtgtttg

27961 aggcatattc ctcattgtct tggctattaa tatttggctc ctctttactt atgcaaattt

28021 ctacagcctg attaattcct ttccaaaaaa atggggtttt cttttctact acatggtcag

28081 gtcacaaatt ttccaaactt ttacgcttcc ctttgaaatg taagttccag ttgcaggtca

28141 tttctttgat cacaaatata agcatatatt tgtagaatca gccaggccac atcttgaatg

28201 ttttgctgct tagaaactgc ttccaccaga taccctaaat cattgctatc aggttcaaaa

28261 ttctacatat ctctagggca agggcacaat gcctccaaga cctttgctaa tgcataagaa

28321 aattgacctt tgctccagtt cccaataagt tccccatctt catctgaggt ctccttagcc

28381 tggacttcat tgtccatatc agtatcagca ttttcatcac aataatttaa ctagtctcta

28441 agaagttcca aactttccct tatcttccta tcttcttctg agccctccaa actgctccaa

28501 cctctgccca ttacccgggt tccaaagctg cttccacatt ttcggtatct ttatagcaat

28561 gctccattcc tgataccaat tttctgtatt agtctcttct cgcactcctg taaagaacta

28621 cctgagactg ggtaatttat aaagaaaaga ggtttaattg actcacagtt ccacaagctg

28681 tataggaagc atggttcaga aggccacagg aaacttacaa tcatggagga aggcgaagag

28741 aaagaaggca cgtcttacgt ggctggagta ggaggaagag agtgaagggg gaggtgttac

28801 acacttttaa acaaccagat cttgtgagaa ctcactcact atcatgagaa cagcaaggga

28861 gaggtctgcc tccatgatcc aatcacctcc taccaggctc ctcctccaac attggggatt

28921 atgatttgac atgagatttg ggtagggaca caactccaaa ccatatcaat cccatttata

28981 tgaaatgtcc acaatagata aatctataga gacataaaat agattggtgc ttgcctagtg

29041 ctggacgtga caggagggtg tgagtaaaag aggcaatgga gtgataggta cagggtttct

29101 ttttggggtg atgaaaatat tataaaatta gattgtggtt atagttgtat aactcttgaa

29161 tatcctaaaa atatattgaa ttttccattt ccattttaaa tgggtgaatc ttatggtatg

29221 tgaattatat ctcaataaaa ctgcaaaaaa tgcacaattt gcaattgcaa aaatatggaa

29281 ccagtccaaa tgcccatcaa tgagtggata aaggaactgt ggtatatata tatatatata EPI-109 1 113

29341 tatatatata tatatatata tatatatata tatatataca cacacacaca caccatggaa 29401 tactactcag ccataaaagg gaataaaaca atggcattct cagcaacctg gatggaattg 29461 gagaccatta ttctaagtga aataactcag taatggaaaa ccgaatatca tacattctca 29521 ctcataagtg ggagctaagc tatgaggatg caaaggcata agaatgatat aatggacttt 29581 gggaactcag ggaaagggtg agagaggggt gaggaataaa aggctaccca ttgggtacag 29641 tgtacactgt tcaagtgatg gctgcaccaa aatctcagaa atcaccacta aagaacttat 29701 ttacataacc aaataccacc tgtttctcaa aaacctattg aaattaatta atttttaaaa 29761 actgctgaaa tcaatagtga aaggatggac tattcaataa tgacacagtt aattgaatat 29821 catattttaa aaattagatc cttacctcac actataacat aacaataaat tccaggtgaa 29881 ttatagacca aatatgaaaa gcaaaatttt aatattttag aagacaattt ttatgacctt 29941 aagttagaaa atgattttta aaaacaggat gcaaaaacac taatcataaa gagatatttt 30001 aggccaagca tggtggctca cacctgtaat cctagtactt tgggaagctg aggcaggtgg 30061 atcacttgag gtcaggagtt caagacaagc ctggccaata gggtgaaaca tgtctctact 30121 aaaaatacaa aaattagctg gaaatcgctc gaacccagga ggcagaggtt gcagtgagct 30181 gagattgtgc cactgcactc cagcctgggt gacagagaga gactccacct caaaaaaata 30241 aataaataaa aataaagaga gattttaata aggtgcatta aaataaaaaa ctatccatca 30301 aagacaccat gaataaagtt aaaataggcc acaatgagaa tatatttgcc atgaattttt 30361 tctttttttt tgagatggag tcttgctctg tcacccaggc tggagtgcag tggtgcaatc 30421 tcggcttact gcaaacttca cctcccaggt tcaagcaatt ctcctgcctc agcctcctga 30481 gtagctggga ttacaggtgt gtgccaccat gcctggctaa tttttgtatt ttttgtagac 30541 acggggtttc accatgttgg tcaggctgag ctcaaacccc tgacctcgtg atccaccttc 30601 ctcagcctcc caaagtgctg ggattacagg catgagccac cgtgcctggc ctaccatgaa 30661 tattttttta aaggtagcat ccagaattaa taatcttctc caacaaattt cattagtagt 30721 cagggaactg caaattaaaa tcaaagtaaa atactacttt ccactcatta gactaaaatc 30781 cattcaagtc tgataatacc tagtactgag ttggagtaat agaaactgct aatgggacag 30841 ttagttggtc atcactttgg agagaaatta gtcagtatct agtaaaagtt agtgatacac 30901 cttccatttt catctgttct gtgctgctac caaagaatac ctgagactag gtaatttata 30961 aataatagaa atgtatttct aatggttcta gaggctgaga agtccaagat tgaagggcca 31021 gcctctgcag agagccttct tgctgtgtca tgccatggca gaagggcaaa gagagggcaa 31081 gagagagcaa aagcaaattc acagcatcaa tcccttttat aatcagcatt actctattaa 31141 tgagggcaag accctcatgg cctaatcacc tctaaaaggt cacacctctt aatactattg 31201 caatggtaat taagtttcta atacatactt tttgggagac attttcaaac tatagcacct 31261 accctatagc ccaacatttc tactcctagg agtatgccct agagaaattc tgcataaata 31321 tctaaagaga ggccattgtt gcattgttag gtactggaaa attggaatca attactatgt 31381 ctaccagcag cagaagatgg ctttttaaaa gttttggttt attcatgaaa tggaatattg 31441 cataaagtat gctccatctc accagatgaa aacatttttc actaggacta tttcaaaagt 31501 agtcttatca ctgggcttct ctattatgca taaaaatttt aagtgaacat gttctttgac 31561 ctagtactcc tacttttagg aatttgccca aaagggacaa ttatactact gggataaatc 31621 tttgaatcat aaagtaagtt gtaaatggta caagcagtat gtcttatttt tatttaaagc 31681 acattaacaa tattacacat atagtaaaaa ataaataaat aaaacatgtg aataataaac 31741 acccaattta gaacaagtgt tgacagtgga gagggaaaga gagagaaaga aggagaaatg 31801 gggagtggga gcgggtacac aaggaaattt tagttgcagc tccaaatttt tactttttac 31861 acaatgaagc gaatatggca aaataagatt tgttaaagtt gggcagcagg tacacagata 31921 ttctatcatt atcctttgaa tatttctgta gatttaagtt gtccattaaa aaaataaaat 31981 acacacataa tttttaagat tagttttttc tatttcctgg ccttcgcatg cactgttaac 32041 tttacctgga attctttatg cagtaattaa gagcaaaggt gtagagcaag actgcttgag 32101 cttggatccc agcactgagt tgatttaggg agaataactt aatctcttaa tcccaagaga 32161 aaatatgata taatagtttt gagctcataa agttttcata agcattaaat gtgacctata 32221 tatgtaaagc aatctaacag tgcctatagt atttataagt gtctgcatta ccaaattcat 32281 cattatcatg gcatgtcatg tcaccatcca ctacattacc atcactgtca ccatcatcat 32341 catcaccacc accatcatca ttaactccct ttgtctagtc aattcatatt tgttcttcgt 32401 attttagata cctgttaaaa tattttttca aagatgtcta ctctgattct tcagtacaaa 32461 tttgatttaa taagatccta tcattttgtc caaatactta taaaaatttg tagttctata 32521 tttaatgtgt tttgtttgtt taacatctct ctcctacatt gtgttaagtt ttttaaagag 32581 aaggtaaggg ttaaagagag acatagagag agaaagagag acagagagag agagagagcg 32641 gttctacagc aatacaggta tattagaaaa acctgcaaag gtggggacca gcttaatgcc 32701 agagcccccc actgcttata ggctggggta cttataggtc tgggggtact tataggcctg 32761 ggtgggtggg gtctgagcag tatggcttgc tgcccaagaa gatgttgata agacgttccc 32821 atgatgaggc agtttggtcc ttgcttccat agagtgtgat gcttcttgca ctttttccca 32881 gcagaatgtg gtagggatgt tccttcaggt gggcctttgc ctggcagggt atgataagga 32941 tgttcctgtg ccttggaatc aggtagttag acaggatgtt tctcacagcc tgaaccccca 33001 tggaatgttt cactttgacc agggtctgcg aaatagcagg gggcttacaa aatggtgtag 33061 tttggactaa caccttggaa cacaaaagtt tcttggggcc aaggctggcg tattagtctg 33121 ttttcatgct gctagtaaag acatacctga gactgggtaa tttataaaga gaaaagaggt 33181 ttaatggact cacaattcca catggctgga ggcctcacaa tcatgaggga ggcaaaggag 33241 gagcaaaggc acgtcttaca tggtggtagg caagagaacg tgtgcagggg aactgccctt 33301 tataaaacca tcagatcttg tgatacttat tcactatcaa aagaacagca cgggaaaaat 33361 ctgcctccat gattcaatta cctcccacca gattcctccc atgacatgtg gtaattatgg 33421 gaactacaat tcaagatgaa atttgggtgg ggacacagtc aaaccatatc agctgggtat 33481 gttttattca cctttttata cccattgtca tgtcttctgg acaaacaatg gatgtaaaat 33541 ggtatagact cctgagtact catttgttga atgacaaatc tatgaaccat ttgaccagta 33601 tgcagcagcc attaaaatta tgtttatgaa taatttacag catggaaaaa tttggggttg 33661 ctagtagaaa aacaaaaagg tacaaaagga tatatataat aagcctacaa tgccatataa 33721 acaatactaa cagcaaaaac aaacctataa attgggggaa gatggggcag atagaagtaa 33781 cctaaaatac taacatgttg ttttggggtc atgaaattat aaatgattat gcacccctta EPI-109 1 1 14

33841 atttttactt tctatgtttg atttttctat ggtaaatgca tttttattga ggtggaattc 33901 acataacatg aaatgaaaaa tttagtggca tttattatat tcacaatatt gtacaaccac 33961 tagctctact tccaaaacat tttcatcact ccaaaataaa accttgtacc cattaagcag 34021 ttactcccca ttatttcctc tcttagctcc tagcaaccac caacctgctt tctgtctcta 34081 gggatttatt tattctggat attccataaa aatggaggca caatatgtac cttttatgtc 34141 tggcttcttt caccaagcat gtttttgagg ctaatccaca ttgcagcatg tatcagtact 34201 tcatttcttt ttatgaataa ctgtatacag accacaattt gttatccatt ttttggttta 34261 tggacatttg ggttgtttcc atctctcaac tattgtgaat agtgctgcta tgtatatttg 34321 tgtacaagaa tttggttacc tattttcaat tcttttatgt atatatctaa gatgaaattg 34381 cagggttata tgctaatcct atgtttagca ttttttttta ggaaccatta aactgttttc 34441 caaatctgat gccccatttt atattcctac tagcaatgta agcaagttcc aatttctcca 34501 tatcctcaac aacacttgtt attttctatt tttgttatag ccattctaat gagtgtaaag 34561 tgatatatca ttgtggtttt ctttgcattt tccttatgaa cattgatgtt gagtaccttt 34621 tcatgtactt tttggtcatt tatatatcat ctttggagaa atgcctcttc gtgtatgttt 34681 tgcccatttt aaaactagat tgtctttgtt gttgacatgc atgcattctt taaatattct 34741 gcatactagg cccttatcag atatatgatt tgcaaatgtt ttttctcatt ttactggctg 34801 tcttttcact ttattgataa tgtcctttga tgcccaaaag ttgtttattt tgatgaagca 34861 tatttatcaa tttatttctt ttattgctca tgcttttgat gtcacctcta agaatttata 34921 accaaatcag aggtaatgaa ggtttacccc tctattttct tctaagagtt ttatagtttt 34981 gactcattta cttaggtcgc tgattcattt ttagttaatt tttgcatatg atgtgaggaa 35041 gaggtccaac tttactcatt tgcatgtgga tattcagctg tgccagcacc atttgtgaag 35101 agtctatcat ctcctcattt aataatagta ttgacacctt tgttgaaagt caattgataa 35161 taaatgtatg agtttatttc tggaatctaa attctattcc attgatctac atgtctatcc 35221 ttgtatcagt atcacactat cttgattact gtagatttgt agtaagtttt gaaactagaa 35281 agtgtgagta ctgcaatatt cttctttttc ttttttaaag attgtcaggg cctcttgcaa 35341 tttaataggg atatgaggat tgacttttct attctacaaa attaaaattt tgttagagat 35401 tgcattgaca ctgtaggtag ctttcagtaa cattgccatc tcaacaattt taagtattct 35461 aatacatgaa tatgagcttt ctttctcttt atttaggtct tctttaattt ctttcagcag 35521 tgttttgtag ttttggggta caagtctttc acctttaaat tttggtgaaa tttattccta 35581 ggtattgcat ttttttatgc tattgtaaat aaaattattt tctcaatttc ctgttggatg 35641 ttcattgcag gtgtatagaa actcaactga ttctttgtgt tgatcttatg ctgagaccag 35701 ctcagttggg gagaccctaa cctagaagca ctagaggaat taaagacaca aacacagaaa 35761 tatagaggtg taaagtggga aatcaggcgt ctcacagcct tcagagctga gagcttcaaa 35821 cagagattta cccacatatt tattaacagc aagccagtca ttagcattgt ttctatagat 35881 attagattaa ctaaaagtat cccttatggg aaacgaaggg aagggctgaa ataaagggat 35941 gggttgggct agttatctgc agcaggagca tgtccttaag tcatagatca ctcatgctat 36001 tgtttgtggt ttaagaatgc ctttaagcgg ttttctgccc tgtgtgggac aggtgttcct 36061 tgccctcatt ccggtaagcc cacaaccttc cagcgtgggc attatggcca tcatgaacat 36121 gtcacggtgc tgcagcggtt tttatggcca gttttggggc cagtttatgg ccagattttg 36181 gggggcctgt tcccaacaat cttatacctt gcaattttgc tgaatttgct tgttaacttt 36241 gatagttttt ttgaggatta tttgggattt tctacatatc atgtcatctg tgaataaaga 36301 tagttttgct tctttctttc tcatttggat gccttttatt tccttttctt gcctaatttc 36361 cctggctaga acttccagta tgatgttgaa taaccatggt gaaatgggca ttcttgtctt 36421 tttcctgatg ttagagagaa atttttcagt ctttaaccat tgagtataat gttagctgtg 36481 ggttttttac aaatatcttt tatcatgttg aggaagttcc ttcctactcc tacttcttgg 36541 agtgtttttg atataaaggg tatttaattt gtcaaatgct ttttctgtgt cagttgagat 36601 tatcatgtga gatttttttt ccttcattct attagtgttg atgttacatt ggttgatttt 36661 ttatgttgta ctacatttgc attctttata taaatttcac ttggtcatgg tgtataaccc 36721 ttttaatatg ccattggatt tagtttgcta gtattttgtt tagagttttt gcatctatat 36781 tcataagcaa tatcagtcca caggtttttt gtggtttatt tgtctggctt tgctataatg 36841 gtaatgctgt cttcttagaa tgaatgaggg agtgttttct cctctttcat tttttaaacg 36901 tttgagaagg agtgatatta atttttcttt aaatgtttgg tagaacttac cagtgaagcc 36961 gtctggttct taacattttt ctgtgttggg aggtttctga ttaccaattt gatctcttta 37021 atttttacag atcttttcag attttctatt tcttcttgag taacttttta gcaatttatg 37081 tattttagaa atttgttcat ttaatctagg ttatttaatt tattggtgtg cattttttca 37141 tagtattatc ttataatctt ttaatttttg taaagttgat aatgtcccca ccttacctga 37201 tcttagttat ttgtgtcttc tctgtattct ttttgtcttc ttcttctgtc ttagcatagc 37261 taaaggtttg tcaactttgt tgatctttta aagagtcaac ttttgctttc agcatgcatt 37321 actttttaaa tagaaatata tacacctaag ttgcattaca aaggagttgt cctccacaca 37381 cttattcttt cccaccatca gaggtttatg gtccccgcaa aagtcaccat cagttgggct 37441 caactccaat cagtcatggt aggtcagggt ccatctcatt gtctccatca ctcatgccca 37501 cccagggtaa gtctaatcat gttcaccaat cagaacctct gccacatcag ctctgtgggt 37561 ttcctctcat gccatctgta ccaacaatga gcacagtctg ggtttcctga tgttttctat 37621 agcatggtgc ccctccctgg gacacctcag aagccacaat gatattcatt aaacttcttc 37681 ctgcaagtac tccctctatt gctccttcta ctcaccaagc ttagtgtcag ggaatatgct 37741 ggtggggagt atgaatctta gcttctcact cccagactcg gctcccaacc tgctgttgcc 37801 aagtcttggg gacatctata aatgccttct aaatacctgt cttggcctat ccccagccac 37861 agattcctcc ctagagcagg ctacctctga ggcatctata ctgagatctt aatcacagag 37921 acatttaaaa catctaggct acaaaagaat tcctactata gggttcaaat gaatttcttt 37981 ccgtcacttg agacagcttt ttagcaagta catgtattaa agattctgat ttcccctttt 38041 ttctcctaca gtttgtttgg cctaaaggta tgacatctaa tctgctgcat ttacactcta 38101 agtcaaaatt accattttgt tcttttaatt tctatttcta atcatacatt cttgtctact 38161 cctggttcat ctggagacaa agttgaactt agaagatgga ggagaaattc ttatctgccc 38221 tctgctagtt gacacttcct ttccaagaat catttgcagt tgctgggctt tcttgctgtg 38281 actctatgcc ctgttgtgtt actttttcat ttgtgacaaa aacagtggta atagtttgct EPI-109 1115

38341 tcatttttat tatgaagact tgaccaggat aggtaggaac ataattactg ctttttctgt 38401 gggcatcata ttggtccaga tcatgtttaa ccagaattga agatgtaaaa tcctagaact 38461 cactaatcta ttttagtagg tcacaggaag catgcaaacc ataaaaaccg caatgaacca 38521 aaagcatctg tgttgacaag aggcaagaat ttctctattt tctaaaggca ctaactgaac 38581 aaatctattg cccattactt aggaaattgc taagggcatc gttaaagtac ttcaggctgt 38641 tgaaaaacct tttctgtctt cttgccccac caccaattct ctctagctat gctttctctc 38701 acatgttctt gccatccatg gagtggcaga gaggttctga gtacaactct aactttcagt 38761 ttcaatggcc taatccccaa ctcaactgct gaccttgagt gtaaaaataa acaagatctt 38821 aaacatctta gggccagcat tctgggtctt cttttgttat ttggggagca taaactattc 38881 tcatatcatt ggcttgcaga aaaattgagc ttctcctctt ccttgcccca tgtcaccttg 38941 aggtgaccac agccctgcct tctatgtaat cctgcttggt cagcaggcac atcagagctc 39001 agtggcttgt gacatacttt ccttcaagcc tgctcgaagg gccatactca tcattgagac 39061 tgggaacctt agaaaccatg aacccagtgc caatgggtag atacagaatt ctcaaactca 39121 tgaaaaaaca tcctttttaa ctctctccgt gtgcataaag aattctaaga tgtactgatc 39181 aagattccca attttctaac tatctattaa tatatggacg aggtaagaag aaagttgcaa 39241 gaaaaaaatt tgtttgactt gacggttgtg tggttatttg ccacactccc ccagatccac 39301 tctgagtccc aggatgctga ttttaggggc tacattgcct agactgtcca ttattccctc 39361 ttcccatctg gttcagtcac tgggaagcac tggtaggagg tcagagtggg agaaggaggt 39421 taggatactt tctgcccctg ctgtcctact gctttgctga acttctagca gtggctgagc 39481 catcaacctg cagctctcaa ttccagctgt ctgtagcact caagtggtat tgtttattct 39541 tttgatcctt ctagctgtta aggaagaaaa aaataatttt ttcctcaatg ctcataagtt 39601 cttggaatgg acccctgtaa caaaagacag attaacacga gaaaagttta ttaacgtaca 39661 tattttatac gtacatagga gctatccagg gaatgaataa ttcttaaaaa ggtgactttg 39721 aattccagct catatagcat cttcaacaaa gttcagtaac attttagaga tatgacaaga 39781 caaagaaaat gaactttgag cctctaggga cagtgacttg taggaaggca aaaggaataa 39841 atggaggtaa aggctggtta gtaatacttg ttaatgaaga ttcctctggt gccatctcca 39901 ggtccacaag gatttaaatt tgtcttcagt ggtgaacctt tgttcaccct ggcagaaggt 39961 gtggaggggg gtgcagatcc gttttgtctt tgtaagtcta tatcctgctt ttagacaaat 40021 aaagggaggg aaaagagctt tccttcatct gcttcttaat tgccttcagc tcaacaatcc 40081 ttatgcaaaa gaggtacatt ttagggtgtc aaattctggt ctcccacaaa gcatagggat 40141 gacagaccac ctcaccatcc ctgttgcttc ttttaagcct gctcacccct ccaaaaatat 40201 tttcattcta tactgtctct tcaaaatctc agcggagggt gccctctgtt atcctgccct 40261 ctgtgtcagt ataagccaaa ggtttgaatc ctggctctgc aactatctac ctctgtgcct 40321 ctccttgttt atgaaattac agggctggag acaaagatca caatgtgaag acaaaattgg 40381 agagcggtcc taatcagcca gagcaaaatt tctggctctt gctcttcccc atcctgggtt 40441 gaatcatagg aacaggtggc aagatgccag ggtcaggaga ttccagaagt ggcagcaagc 40501 tcagtgttac caggtcaggg atgacctgtc ttattattga aatctcagag atatgctcca 40561 attccggccc agagacacat tgagagacaa ctggggaact tgctatgttc ctgaacaggc 40621 aatgagctgt cttccaagaa aaaacctgag acccttcaag tctcaggtct tacttagcac 40681 atataccagg tcttacacag gacacatggt tacaactgac tgaaatctgg gctgggtgta 40741 ggagctcaca cctgtaatcc cagcccttca ggaggctgag gcaggcagat tgcctgagcc 40801 caggagttcg agaccagccc gggcaacatg acaaaacccc atctctacaa aaaatagtca 40861 ggcatggtgg catgcacctg tagtctcagc tacttgggag gctgagatga gaggattgct 40921 tgaggttgag actgcagtga agcatgatca tgccaccgca ctccagccta ggcaacagag 40981 caagatcttg tcgcaaaaga aagcaaaaac acaacataac acaacaacaa caacaacaac 41041 aacaacagca aaaaagccaa cttcttgaaa tctggaaagg acacctggac tgccctgagc 41101 atttgattgt tgttggctct agcagtggat gcatccttca acctctggca ctctgcaggg 41161 ctcagactgt tctgttctgt ttgttacctg tggagtgcct gccagaccct gctctagctg 41221 ctttaggtcc atttaccctc atagaccccc agtcttgtta ttcatatttc atatttggga 41281 aatggaaact tagaaacttg ccaagtccac agcatgagat cctgcctccg gtgtctgctg 41341 gattccagaa agtgccaggg gccaacttag atgacaccat gttctctgca caatcttagg 41401 aatgctccta gtctgatgtc cccattgcaa aatttacatt atcttttaac aaaacgtctt 41461 tccaaggagg ggcatttaaa ataactgagg ttcttcttgc taaggacgtt cctgacacaa 41521 gagataattt agcatttcct tttcattaaa aagtttgaaa tcctgtaatt tgtgataatg 41581 tggatgaacc tagaggatgt taagtgaaat aagccacaca cagatagaca aataccacgt 41641 gatctcactc ttatgtggaa ttttttttta aataagttgc ttagccgggc atgatggcac 41701 acacctgtaa tcctagctac tcaggaggct gaggtgggag gatggcttga actcagaagg 41761 tggaggtagc agtgagctga gactgtgcca gtgcactccg gtctgggtga cagaatgaaa 41821 cccaatttaa aaaaaaaaaa aaagttgcta tcttagaaaa agacagtaga gcagtggtta 41881 ccagagactg gggaggaaag agaggaggtg agaatgggca gcagttgatc aacgggtaca 41941 aagttaccat gagataggag aaacaagtgc tggtgctctg ctccaagtag ggtgacggta 42001 gttaataatg aattctgtat atataaatag ctagaagaga gggttttcaa tatcattatt 42061 atttcaaaag aaatgataaa tgtttcagag gatggatatg taattaccct gatttgatca 42121 ttgcacaatg tatacatgta gcaaaacatc acattgtgtc ccataaatat atacaattat 42181 tatgtgaatt aaataaaaaa aaattttaaa gtcttatcta aatgaaattt ctaaccagat 42241 tctgaatcca tgataccact gaaaccagca cacatgatcg cagtaaaacc tcattatact 42301 tcctccacta tcaccaatac cctttattct ctggaacatg aaacattctg ttgtgctcat 42361 atcatgcaaa ttatcactag taggagagca gagagtggaa atgttccagg tataaagacc 42421 cacaagataa agaagctcag agtcgttaga aacaggagca gatgtacagg gtttgcctga 42481 ctcacactca aggttgcata agcaagattt caaaattaat cctattctgg agacctcaac 42541 ccaatgtaca atgttcctga ctggaaaaga agaactatat ttttctgatt ttttttttca 42601 aatctttacc attagttgcc ctgtatctcc gccttcactt tctgcaggaa actttatttc 42661 ctacttctgc atgccaagtt tctacctcta gatctgtttg gttcagttgc tgagaagcct 42721 gacataccag gactgcctga gacaagccac aagctggtga gttgtaggca ttttttccat 42781 tactttctga ttcataggct caacgcacct caaagctgga aatgccgggt ctgggtacac EPI-109 1 116

42841 cctggggaac tgcaaagcct gcacacttgg gggaaatgat caagataaga ggcaggggtg 42901 gggatggcat gtgcaccagg agatgttaga gaaaccctga ggaagagcag cgtgcagcag 42961 gtgatggggg agagtgggca gcaagcgagg ccaggacagc cactctgatc agtcaccagt 43021 ccacacaccc aggggctcac tctgcccctc tgagcaccca aggacgttaa agagctggaa 43081 ctgttagtct aaatatagga ccatccaagc tctgaaccaa aatgtgtccc ttgcctcaac 43141 tcaggagatc cacagaggca gaagtaagga atttattttc tgaaagatag atttctatca 43201 gttctgggtg acatgttctg acacttgaaa tgacacctag gacagcacat ttcaggcatc 43261 ttgctcattg ttcactgtag tagaagctac atgctagcca gttgtaaaaa tgaaattaag 43321 taatgtgtgc acagcattta acatagcatc tgagcttcag gagcactcaa ttaatgacca 43381 cagttgtgat tctttaggca gatgcatttt tttccaactt tgatcagagg tcttatttag 43441 cttctccaga tttcaagaat ctggctcagt gatatgaaat acaagacttg tgaaaagtgt 43501 caattgcaag agaaatggaa ggataaagta tacaggtggg tggaaaagaa attcacagtc 43561 actgccagaa aaaaaattct tgagaatcaa gtcctgatga tgttagggct tatagttctt 43621 attataaaga gttttatgta ctcattcagt gaacatttat tggtgcctcc tttagccagg 43681 tactatcata agagctgaaa ataaaagcat aatccagtcc ttgatcttga ggaacatgct 43741 gtgtgtagca gataacataa taagtgctta tctagatgca tgcagtgtta tgtgataaga 43801 gtaatatgac agaggataca gattaggctt cacagagaag ggggatttga gcaggaggta 43861 ttgaagggtg aatagaagct caccaatcat tttgggcaga ggggcaagga cctgcaaaac 43921 cactgaagca tgaaggaaat ggtgagttta gggaaaatga agagaagatg gctgtgactg 43981 aagcacagga tttgggattg gagaagggac tggaggtgag gctgagaaga ggcaaactca 44041 gaaaagatgt tgtgctgggc agtctggaca ttatctttga agcccaccac atataagtca 44101 tagggctact ggaggtttta agctaaaagt gactattcaa tttcaactta agagaagata 44161 ggttgagagg gaacatggct tgagatgagc catgagcaaa ggaaagacta caacaaagcc 44221 aggagtgagg agtgtgtgaa gcaagaaagt gacagttgaa agcagtgcag aggggatgaa 44281 tctgagaggc atctatgagg tggaactcaa atgacatgat aataatacag ggcatttctc 44341 tgtgtcagat gctgtcctaa gtccttactc cattgatctt cacagcaact cagcatagtt 44401 aatattttat gcataaagaa atcggcactt gaaggagtaa ttggccccag attacactgc 44461 ctataaggat tcaaatccag gtttgtttgg ctccaaaaac tggctcctaa ttttcagaag 44521 gagaagcgac ccagggcaat gcccaatttt gcttcttagg caatggagga atccacaatc 44581 ggaaggagtt ttcagcagtg ccccatttgg ggtgggttga atttgaggtc cctgcatgat 44641 acccactttg ctcacttcag tgcctaaaac tgagtatggt tcatagtagg tgttcaataa 44701 gtgttgatgc agtgaataca tgcatgggga gatatgcatc aggcaatggg aaattcaact 44761 ctaaggctta ggggaaagct ggagcttgaa gacagagctt tagaaaacag tagcatagaa 44821 gggagtagga accatgagtt tagacaatac aattcaggaa gaactttgta gcaaggataa 44881 agaggcaaaa aattaaagag gtgagagcta agtgtggtgc ctggggaatc ttaaggtgtg 44941 ggcacgggga ggagatgcca gcaaagaaca tgaataaaaa gcggtagcac agcccctccc 45001 atctggaagc caaaaagaat tgtaaatgga ggaagttagc agaaggatca aatacttgaa 45061 gagggtggaa ttggaataaa accagggcat ttgaaaaatt gggttgtcac tgcaatctta 45121 acaagagaag ttttggcagg atgatggagg cagaaagctg agagaatcat cagttagaac 45181 gtttttgact tcagagaaca gaaaatgcag ttcataatgg ctttaaaaca ggggcttgtt 45241 tttctcccag caatttgaga ggccaaggcg ggtgcatcag gaggtcaaga gaccgagacc 45301 atcctggcca acatggtgaa tccccatctc tactaaaaat acaaaaatta gcggggcatg 45361 gtggtgcacg cctatagtcc catctactca ggaggctgag gcaggagaat cacttgaacc 45421 caggaggtgg aggttgcagt gagctgagat catggccact gcactatagc ctggagacac 45481 agcgagactc cgtctccaaa aaaaaaaaaa aagaaggcag aaggtgaata gttcaagggt 45541 gggtttagga ctcagtgata ataggattct gcctggcttc tcatggttct ctaggtcttc 45601 cattcatggc accatgccct cactaggcat gctgccagag caggaggggc aggtggaggg 45661 ttctcttgtg tctgtcttat cagggaagaa gagctttctc agaagccαcc agcagactcc 45721 cttttcatat tatggtccag caatgagtca cagacctatg caccacctgc aaaggagcca 45781 gagaaaacaa acgcccagcg cttttagcct gaaaatgaga atctggtttg ctggggaaga 45841 taaagggtgt cggaaaatgg ctgttgggta aatcattgat gtctgccact aggaatgaaa 45901 ggcaaatcag gaactggcac acatgctttc agggagatgg ctgcaaggga gagggcaaag 45961 actgggaagt tgcttatgtg gtgccagact atttggaaga tcatggattg cggtgtttgt 46021 gttgtgtggt catcattttg ttctttgttt acagaacaga gaaagtggat tgaacaagga 46081 cgcatttccc cagtacatcc acaacatgct gtccacatct cgttctcggt ttatcagaaa 46141 taccaacgag agcggtgaag aagtcaccac cttttttgat tatgattacg gtgctccctg 46201 tcataaattt gacgtgaagc aaattggggc ccaactcctg cctccgctct actcgctggt 46261 gttcatcttt ggttttgtgg gcaacatgct ggtcgtcctc atcttaataa actgcaaaaa 46321 gctgaagtgc ttgactgaca tttacctgct caacctggcc atctctgatc tgctttttct 46381 tattactctc ccattgtggg ctcactctgc tgcaaatgag tgggtctttg ggaatgcaat 46441 gtgcaaatta ttcacagggc tgtatcacat cggttatttt ggcggaatct tcttcatcat 46501 cctcctgaca atcgatagat acctggctat tgtccatgct gtgtttgctt taaaagccag 46561 gacggtcacc tttggggtgg tgacaagtgt gatcacctgg ttggtggctg tgtttgcttc 46621 tgtcccagga atcatcttta ctaaatgcca gaaagaagat tctgtttatg tctgtggccc 46681 ttattttcca cgaggatgga ataatttcca cacaataatg aggaacattt tggggctggt 46741 cctgccgctg ctcatcatgg tcatctgcta ctcgggaatc ctgaaaaccc tgcttcggtg 46801 tcgaaacgag aagaagaggc atagggcagt gagagtcatc ttcaccatca tgattgttta 46861 ctttctcttc tggactccct ataacattgt cattctcctg aacaccttcc aggaattctt 46921 cggcctgagt aactgtgaaa gcaccagtca actggaccaa gccacgcagg tgacagagac 46981 tcttgggatg actcactgct gcatcaatcc catcatctat gccttcgttg gggagaagtt 47041 cagaaggtat ctctcggtgt tcttccgaaa gcacatcacc aagcgcttct gcaaacaatg 47101 tccagttttc tacagggaga cagtggatgg agtgacttca acaaacacgc cttccactgg 47161 ggagcaggaa gtctcggctg gtttataaaa cgaggagcag tttgattgtt gtttataaag 47221 ggagataaca atctgtatat aacaacaaac ttcaagggtt tgttgaacaa tagaaacctg 47281 taaagcaggt gcccaggaac ctcagggctg tgtgtactaa tacagactat gtcacccaat EPI-109 1 117

47341 gcatatccaa catgtgctca gggaataatc cagaaaaact gtgggtagag actttgactc 47401 tccagaaagc tcatctcagc tcctgaaaaa tgcctcatta ccttgtgcta atcctctttt 47461 tctagtcttc ataatttctt cactcaatct ctgattctgt caatgtcttg aaatcaaggg 47521 ccagctggag gtgaagaaga gaatgtgaca ggcacagatg aatgggagtg agggatagtg 47581 gggtcagggc tgagaggaga aggagggaga catgagcatg gctgagcctg gacaaagaca 47641 aaggtgagca aagggctcac gcattcagcc aggagatgat actggtcctt agccccatct 47701 gccacgtgta tttaaccttg aagggttcac caggtcaggg agagtttggg aactgcaata 47761 acctgggagt tttggtggag tccgatgatt ctcttttgca taagtgcatg acatattttt 47821 gctttattac agtttatcta tggcacccat gcaccttaca tttgaaatct atgaaatatc 47881 atgctccatt gttcagatgc ttcttaggcc acatccccct gtctaaaaat tcagaaaatt 47941 tttgtttata aaagatgcat tatctatgat atgctaatat atgtatatgc aatatatata 48001 ggctcttgct tgatctctcc aggaggtagt gattatgaga agggggtgga gaatgatgag 48061 ttccttcacc aggagcaaag gacggggatc gtgtggaacc actgcagaac tatttccgga 48121 atcaactaag tggagagagc caggaaggct gcatcagaac ccagtaaagc ttcttgtctg 48181 gatctgagct ggtttgtttt gtgcttgctt ttccctgcct tgccactccc ctcactcttc 48241 tcttttcccc acagcctttt tcacatagct cttggctgta ggattgcccc actccaaaaa 48301 ccagtgtgtg gaggtccagg agtgagacca ggaaagaatg tgaaagtgac tacacaagga 48361 ctcctcgatg gtcgtggaaa aggaaagtca attggcagag cccctgaagc cagtcttcag 48421 gacaaagaag gagcctagag acagaaatga cagatctctg ctttggaaat cacacgtctg 48481 gcttcacaga tgtgtgattc acagtgtgaa tcttggtgtc tacgttacca ggcaggaagg 48541 ctgagaggag agagactcca gctgggttgg aaaacagtat tttccaaact accttccagt 48601 tcctcatttt tgaatacagg catagagttc agactttttt taaatagtaa aaataaaatt 48661 aaagctgaaa actgcaactt gtaaatgtgg taaagagtta gtttgagtta ctatcatgtc 48721 aaacgtgaaa atgctgtatt agtcacagag ataattctag ctttgagctt aagaattttg 48781 agcaggtggt atgtttggga gactgctgag tcaacccaat agttgttgat tggcaggagt 48841 tggaagtgtg tgatctgtgg gcacattagc ctatgtgcat gcagcatcta agtaatgatg 48901 tcgtttgaat cacagtatac gctccatcgc tgtcatctca gctggatctc cattctctca 48961 ggcttgctgc caaaagcctt ttgtgttttg ttttgtatca ttatgaagtc atgcgtttaa 49021 tcacattcga gtgtttcagt gcttcgcaga tgtccttgat gctcatattg ttccctattt 49081 tgccagtggg aactcctaaa tcaaattggc ttctaatcaa agcttttaaa ccctattggt 49141 aaagaatgga aggtggagaa gctccctgaa gtaagcaaag actttcctct tagtcgagcc 49201 aagttaagaa tgttcttatg ttgcccagtg tgtttctgat ctgatgcaag caagaaacac 49261 tgggcttcta gaaccaggca acttgggaac tagactccca agctggacta tggctctact 49321 ttcaggccac atggctaaag aaggtttcag aaagaagtgg ggacagagca gaactttcac 49381 cttcatatat ttgtatgatc ctaatgaatg cataaaatgt taagttgatg gtgatgaaat 49441 gtaaatactg tttttaacaa ctatgatttg gaaaataaat caatgctata actatgttga 49501 taaaagattt aaaaacaact ggctgttttt ttacactgtg gtgtggaaga ttgtgttgtg 49561 ttcacaactt ttcacttctt cccctgtgtg attacacaca cctgcccttg tggtgtgact 49621 tgcagtgcgc cctacaggcc acacaacccc atgccctcca ccactggctc tgctgctgga 49681 atgtgagcag aagtgacatc tgcctcatcc aagcagagcc tcttgctcag ccacaggaag 49741 gcccattcca gatcacaccc gtcagcccgt gcgccctggt gaatgagaag acacagggag 49801 ctgcagccac atataacatg agcaagaagt ctgtgtttgc tgtgataagc cactgagttt 49861 taggggttgt ttgttaagaa gcacaaaaac cgattaagac atgtggtata tagtgacttc 49921 atatatagaa tctggaaaac tatccattta ttttcaatca tggaattcaa tatgacaagc 49981 atcccggagg gtctacctat gccagactgg gttggaaaca gaaagacaga tgttaatgcc 50041 agtgtccttt acacctccaa gtccagggcc agctgtggag tgggaggggt agagaaggtc 50101 ctgtgcacag tcacagtgcg ctgtgcagag caggaacaga ggcatctgtg aaaagtgctg 50161 agagcctgga ggacagagtg actaatgcaa tgacagtctt gcatcatagg aataacagcc 50221 acagcaggat tttattgctg ccaaagaaac tgccatttaa aaattgccag ccatccggga 50281 ggctgaggca ggagaatggc atgaatccag gaggcggagc ttgcagtgag ccgagatcgg 50341 gccactgcac tccagcctgg gcaacagagc cagactccat ctcaaaaaaa aaaaaaaatg 50401 ccagccatct ctctttctaa agtggaatcc tcaagtctcg tttattctgg ggacatttga 50461 gtaggctgtt cgagttaagc aggtggaagt tgatgatccc tcatcatcat tctgagggat 50521 gagtgtctga agactttttg gtaaggaagg gtcttggcat agcccacccc atgccacctc 50581 ccttgatctg tgatatcccc agcagctggg gaggttggag cattttgcaa agaggccccg 50641 aagcctccag aaagtaaacc ttcaagagcc catccttcct tcctcttttg tttttgctca 50701 ttatgaaaac ttccctgaca aattgaaaag gcttcaggtg agattagccc acaggaaaaa 50761 ccaccaaggg ccacccagag gggccacact gtgacagaag gagtatgggc tggtgagctg 50821 acctctggaa gacagtgcat gaattgagga gaagagattg gttccaggca tgggaggaat 50881 gaggctggaa atttcttcag acattgccac ttcggcactc tgtgtgtgtg tgtgtgtgtg 50941 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtaaacaga gtcctgtaat gcaaggtccg 51001 gccttggcag ccccagcctg gagccacagt gagatgtgag ctgagggtta tgctgggaaa 51061 aacctctccc tcccagcacc tgaaaggctc tgcaggccca gcagctcagc aagcaagggt 51121 aagggcatgg actaacatct tatttcatac tatcccttat aacacatcct aatgtaatca 51181 gctcacaata tgaaattatt tcatttctct ccagtcattg tttcaatggg gccttagggt 51241 tgactggatt ctggaggtcc ctgcctagag gagggggtgc attctgtccc tatgtcccct 51301 cctgctccat cctccacagc acgtgcctag tggtctacct tgtggggaat tcttgtacct 51361 ccctcttcta ggcatggact agcattgaga agtgggagag gagtgttagg aaaaagggca 51421 aatatagaca taccttgtct tattgtgctt tacagatatt gtttttgttg ttgttgttgt 51481 tgtttacaaa ttgaaggttt gtggcaaccc tgcctcgagc aagtctattg gtgctgtttt 51541 tccaacagca tgtgcttgtt ttacatctct gtgtcacatt ttggtaattc tcccaatatt 51601 tcaaactttg tcattatttc tatatctgtt atggtaatct gtgatcagtg atctttgatg 51661 tcactattgt agttgttttg gggcaccatg aagtgcaccc atgtaagatg gcaaacaatc 51721 aataaatgtt gtgtgtgttc tgactgctcc atggactgcc tgttcctgag acacaataat 51781 gtatatataa caattatata tatatatatt tataacaatt atatatatat atattttttt EPI-109 1 1 1 S

51841 tttttttttg aggcagagtc gcactctgat tgcccaggct ggagtgcaat gatgtgattt 51901 cagctcactg caacctctgc ctccccaggc tcaggtgatt ctcccacttc agcctcccaa 51961 gctgggacta caggtgtgca ccatcacacc cggctaattt tttttttgta tttttaggag 52021 agacagggtt ttgccatgtt gcccaggctg gccttaaact cctagactca aacaatccac 52081 ctgcctcagc ttcccaaagg gctgggatta caggcatgag ccactgtgcc cagcccaaga 52141 cacaataata ttgaaattaa gccaattaat aaccctacaa tggcctctaa gtgttcaagt 52201 gaagggaaaa gtcccacgtc tctcacttta aatcaaaatc tagaaatgat taagcttagt 52261 aaggaggaca tattgaaagt caaggccaaa agctcacctc tgcaccagtt agccaaattg 52321 cgacttcaca ggaaaagttc ttgaaggata tttaagctct actccaggga acatgcaaat 52381 gaagagaaaa caaagcagcc atattgctaa tatggagaaa gtttgagtgg tctggagaaa 52441 agatccaacc agccacaaca tttccttaag tcaaagccta atccagagca agactctaac 52501 tctcttcaat gctatgaagg cggagagagg tgaggaagct gcagaagaaa agtttgaagc 52561 tagcggaggt tggtttgtga ggtttaatga aagacaacat ctccataaca taaaaatgca 52621 agatgaagca gcaagtgcaa agggagaagc tgtggcaagt tatccagaaa atctagataa 52681 gataattgat gaaagtgtct acacgaaaca acagattttc agtgtagaca aaacagtctt 52741 atgttggaag aagatgccat ccaggacttt cacagctaga gaggagatgt caaggcaagc 52801 tgcaaagctc cacaggacag gctgactctc tttttagagg tgaatgcagc tgatgacttt 52861 aagttgaagt aaatgttcat ttactatttt gtaaatcctg gtgtcattaa gaattatgcg 52921 aaatctactc tatctgtgct ccataaatgg aacaataaag cctggatgac aacacatctg 52981 tttacagcat ggtttactga atatttcaag cccactattg agaactattg ctcagaaaaa 53041 aagattcctt tcaaaatatt actgctctgc accatgtcga tcaagagctg tgttggagat 53101 gtacgagaat attcatgttg ttttcatccc tgctaacaca aacatccatt ctgcagtcca 53161 tggaccaaga ctttcaagtc ttattaagaa atatatttca taaggctatt aagaaatagc 53221 tatatatata tatatatata gccttatata gtttatatag ctaccattga tagtgattcc 53281 attgatggat ctgagcaaag caaattgaaa agcttctgga aagtagtcat tattctagat 53341 gccattagga acatttgtaa ttcatgggag gaggtcaaaa taccaacatt aacaggagtg 53401 tgaaagacat tgattccaac ccccatagat gactttcagg ggttcacgtc ttcagtggag 53461 gaagttgctg tagatgtggt ggaaacagca agagaactag aactagaagt ggagcctgaa 53521 gttgtgactg aattgccgca ctctcatgat caaacttgaa cagatgaaga gttgcttctt 53581 acatatgagc agtgaaagtg gtctcttgag atggaatctc ctcctggtga agatgctgtg 53641 aacacggtta aaatgacaac aatcgattta gaatattaca taaatttagt taataaagca 53701 gtggcagggt ttgagaggat tgactccaat tttgaaagaa gtgggtaaaa tgctatcaaa 53761 tagcatcaca tggtatggag aaatcttttg tgaagggaag agtcgaccaa ggtggcaaat 53821 tgcattgtca tcttatttta agaaattgcc acagccaccc ccagctttag caaccaccac 53881 cctgatcagt aagcagccat caacatcaaa acaagaccgc catcctcttc agcaaaaaca 53941 ctatgacttg ctgaaggctc agatgatggt tagcattttt agcaatacaa tatttttaat 54001 taaggtatgc acattggttt ttctgacata atactattgc atacttaata gactacagta 54061 taggataaac acaactttta tatgcactgg gaaaccaaaa aggttatttt tgagatattt 54121 gctttactgt ggtggtctga agctgaactc acaatctcac caaggtgtgc ctgaacctct 54181 ttagctaact ggccactgcc acagtccact ctgtgttggt caagatgccc cagagtggca 54241 ggcacactgt gtggtcacat ccaagggcct agatatggtg ggggctccaa atggatctag 54301 atatgtgaga tctctctttg atttgacttc ttccaaccca ccattttctg ggtgctgggc 54361 tcatctcacc cagaaagtag gacccaatgt gacagttcct gcccagttcc ctcctgtggt 54421 agccacttga cccaggggca ctcttgatcc ttgcagcctc acttacacac cctatctcta 54481 cccctattaa ctctctccaa tccccactcc ccctgctcag cttgtctgct gcccagtggg 54541 ggccccaccc atgctggcct ctccttttgc aagtccccat tcctcatatg gtttcttcag 54601 agcccctttc tttggctttg aggagagatg ccctcactcg cttccccacc aatcctgccc 54661 acttctacaa tccattcatt atcctaattg cctccgtata cagactggag tgagaggagt 54721 tgatgtgatg ggtgtggata cagggctggt gctgtcatct tctagtaagc cctgggagag 54781 gtgtctgagc ccaggtgtca gtggttttct ttggaactgt gagtgcataa cacttctttg 54841 ccttcagcct taggccatag ttgctagttc tgggacaacc agaaaagccc tacataatct 54901 cgtgttatgt gcagagctga gtatagagct ccaggtatga tctgactcac ttaagatcac 54961 agtgagtcta ttgtattgtt gaactgttag cttagacatc tgttactgta cctacatggc 55021 actagcctca cgcctagaca ccgatctgaa agaaatcccc taaatgcata gagaagactt 55081 ctcagctgag ctaaggggct cccaccaggt ttgagcctat ctaatgaatc catgaggtag 55141 acagcctgca catgtccact tggtttgatg aattgcacaa atccctatgg gggatgtggt 55201 tcatgggctg ggaagtgggt taccctggga aaggtctaca ggacagaggc agggatggag 55261 acaacagcat ggtgagttcc caacccaccc acgatgatag gtgtctgagg cagaaggtaa 55321 agaggctgtc acctggtggg tgtcataaga ctcaagtgtc attgttgagg cacatgggta 55381 acaaagcgtg gcactggatg ggggtagatt cttcctattt ctgtgaggat cagggggact 55441 ccctggctct cctgctaaag gtggctctag ggacaggaag agtgtacttc ttgacaggga 55501 tgtcagagca ctgatggtga caatcagtgt gacactgctc acatgactga acaaccgaga 55561 agagcccgac tgtctactga acaacgggaa gagcccgact gtcaatgacg gagctctgtt 55621 aaatatagtt aaggctattt tgttgaatga atgaagccag acaggaaaga ggacagtatc 55681 tttaatccat ttatagaagt taaagacagg cttatttaat ctctatgaag acagagtggc 55741 ccttacctct gggtggagca aaaggcacct tctgaagtga tagggatgtt ccttatcatc 55801 ttgatccgga gtggtagtta catgcatgta tgcatatcaa aactcaccaa gctgtaccac 55861 taagtgtgtt cttcctcaat aaaaataata aagaactaca cttataaaga attttttaat 55921 aatataggaa aatgtctaca ctataatctt tagctaaaaa aaaaaaaaaa gaagccgcct 55981 acagaatggt atatgcatga gaacaattaa tcgaaaagtg catgggaaaa gtcaggattg 56041 aaacatcatg ttttaaaaga cattgttttg atactgtgag aatgtaccta agtttttcct 56101 tttttctgtt tttcccaatt ttatacaatg agcatgtgtt ggttttataa ttagacattt 56161 tgtttgtttg gtttggtttt gagacacagc ttgctgtcac ccaggttgga gtgcaatggc 56221 ccaatcttgg ttcactgcaa cctccatctc ctgggttcaa gagattctcc cacttcagcc 56281 tcctgagtag ctgggactat aggggcgcac caccacatcc agctaatttt gtgtattttt EPI-109 1119

56341 agtagagatg gggtttcacc atgctggcca ggttggtctc aaactcctga cctcaagtta 56401 tccactcgcc ttggcttccc aaagtgctgg gattataggc atgagccacc gcacttggcc 56461 tagacatttg tttttaaaaa taaaagattc atttgctctt tttacagccc gtctcactgt 56521 tgactgatat tgaccaggag tcaactcagg ccccagggat tttcacaaca gctgctgtat 56581 ggcagggttt ctgctcactg tgctcatgta gttggccctt gcacccaaag tgaataatta 56641 acattctccc catcctgttg acgatgctct gaaaatatgg tccagaaatg gtgtgagcaa 56701 ggagacagca aagcaatgct tggaacatag gtgcagtgac tagacatggg gcagctgttt 56761 aaagacaaaa aggccccaaa aaggagggat ggcacgaaac accctccaat atgggcatgg 56821 agtctagagt gacaaagtga tcaaaagttc atttcctatg gggtgtccga atgtacttaa 56881 taataaaaag agaacaagag ccatgcaaac tgagagggac aaagtagaaa gagtagcaga 56941 caccaagcaa ctaagtcaca gcatgataag ctgctagctt gttgtcatta ttgtatccag 57001 aacaacattt catttaaatg ctgaagaatt tcccatgggt ccccactttc ttgtgaatcc 57061 ttgggctgaa cccccctgtc ctgagtggtt actagaacac acctctggac cagaaacaca 57121 aaagtggagt aacacacact gcaaagctgt gcttccttgt ttcagcctgt gaatcctcac 57181 cttgtttccc atctagccta tatttttcaa actaacttgg ccatagaatc atgtagtatt 57241 tagggtggaa gctgccccag gtctagcacg tcatttaaca gatgaggaaa tggaagcttg 57301 ggcagtggaa gtatcttgcc gaggtcacac agcaagtcag cagcacagcg tgtgtgactc 57361 cgagcctgct ccgctagccc acattgccct ctgggggtga gtatgtcttc acatcctcca 57421 ataccctaat gacagacaaa cagaacatgg caaagcctca gctctgcatg gtgaaagtaa 57481 gaaccagcaa ttgccacaaa cagaaataca gtgttggtcc ggcagcctcc gggggttctg 57541 cacaagtgga ttaccagtga atacaaggct atctatcttt cgaaaaacca acgttgtatt 57601 tatgctattt tctataaaat tttatattaa tttatttgtt acctattttt gaactctttc 57661 aaaagcacac tttatatttc cctgcttaaa cagtcccccg agggtgggtg cccaaaaggc 57721 tctacacttg ttatcattcc ctctccacca caggcatatt gagtaagttt gtatttgggt 57781 ttttttaaaa cctccactct acagttaaga aaactaaggc acagagcttc aataatttgg 57841 tcagagccaa gtagcagtaa tgaagctgga ggttaaaccc agcagcatga ctgcagttct 57901 taatcaatgc cttttgaatt gcacatatgg gatgaactag aacattttct cgatgattcg 57961 ctgtccttgt tatgattatg ttactgagct ctgttgtagc acagacatat gtccctatat 58021 ggggcggggt tgggggtgtc ttgatcgctg ggctatttct atactgttct ggcttttccc 58081 aagcagtcat ttctttctat tctccaagca ccagcaatta gctttacctt ttcagcttct 58141 agtttgctga aactaatctg ctatagacag agactccggt gaaccaattt tattaggatt 58201 tgatcaaata aactctctct gacaaaggac tgctgaaaga gtaactaaga gtttgatgtt 58261 tactgagtgc atagtatgtg ctagatgctg gccgtggatg cctcatagaa tcctcccaac 58321 aactcatgaa atgactactg tcattcagcc caatacccag acgagaaagc tgagggtaag 58381 acaggtttca agcttggcag tctgactaca gaggccactg gcttagcccc tgggttagtc 58441 tgcctctgta ggattggggg cacgtaattt tgctgtttgg ggtctcattt gccttcttag 58501 agatcacaag ccaaagcttt ttattctaga gccaaggtca cggaagccca gagggcatct 58561 tgtggctcgg gagtagctct ctgctgtctt ctcagctctg ctgacaatac ttgagatttt 58621 cagatgtcac caaccaccaa gagagcttga tatgactgta tatagtatag tcataaagaa 58681 cctgaacttg accatatact tatgtcatgt ggaaaatttc tcatagcttc agatagatta 58741 tatctggagt gaagaatcct gccacctatg tatctggcat agtgtgagtc ctcataaatg 58801 cttactggtt tgaagggcaa caaaatagtg aacagagtga aaatccccac taagatcctg 58861 ggtccagaaa aagatgggaa acctgtttag ctcacccgtg agcccatagt taaaactctt 58921 tagacaacag gttttttccg tttacagaga acaataatat tgggtggtga gcatctgtgt 58981 gggggttggg gtgggatagg ggatacgggg agagtggaga aaaagggggc acagggttaa 59041 tgtgaagtcc aggatccccc tctacattta aagttggttt aagttggctt taattaatag 59101 caactcttaa gataatcaga attttcttaa ccttttagcc ttactgttga aaagccctgt 59161 gatcttgtac aaatcatttg cttcttggat agtaatttct tttactaaaa tgtgggcttt 59221 tgactagatg aatgtaaatg ttcttctagc tctgatatcc tttattcttt atattttcta 59281 acagattctg tgtagtggga tgagcagaga acaaaaacaa aataatccag tgagaaaagc 59341 ccgtaaataa actttcagac cagagatcta ttctctagct tattttaagc tcaacttaaa 59401 aggaagaact gttctctgat tcttttcgcc ttcaatacac ttaatgattt aactccaccc 59461 tccttcaaaa gaaacagcat ttcctacttt tatactgtct atatgattga tttgcacagc 59521 tcatctggcc agaagagctg agacatccgt tcccctacaa gaaactctcc ccggtaagta 59581 acctctcagc tgcttggcct gttagttagc ttctgagatg agtaaaagac tttacaggaa 59641 acccatagaa gacatttggc aaacaccaag tgctcataca attatcttaa aatataatct 59701 ttaagataag gaaagggtca cagtttggaa tgagtttcag acggttataa catcaaagat 59761 acaaaacatg attgtgagtg aaagacttta aagggagcaa tagtatttta ataactaaca 59821 atccttacct ctcaaaagaa agatttgcag agagatgagt cttagctgaa atcttgaaat 59881 cttatcttct gctaaggaga actaaaccct ctccagtgag atgccttctg aatatgtgcc 59 41 cacaagaagt tgtgtctaag tctggttctc ttttttcttt ttcctccaga caagagggaa 60001 gcctaaaaat ggtcaaaatt aatattaaat tacaaacgcc aaataaaatt ttcctctaat 60061 atatcagttt catggcacag ttagtatata attctttatg gttcaaaatt aaaaatgagc 60121 ttttctaggg gcttctctca gctgcctagt ctaaggtgca gggagtttga gactcacagg 60181 gtttaataag agaaaattct cagctagagc agctgaactt aaatagacta ggcaagacag 60241 ctggttataa gactaaacta cccagaatgc atgacattca tctgtggtgg cagacgaaac 60301 attttttatt atattatttc ttgggtatgt atgacaactc ttaattgtgg caactcaaac 60361 tacaaacaca aacttcacag aaaatgtgag gattttacaa ttggctgttg tcatctatga 60421 ccttccctgg gacttgggca cccggccatt tcactctgac tacatcatgt caccaaacat 60481 ctgatggtct tgccttttaa ttctcttttt gaggactgag agggagggta gcatggtagt 60541 taagagtgca ggcttcccgc attcaaaatc ggttgcttac tagctgtgtg gctttgagca 60601 agttactcac cctctctgtg cttcaaggtc cttgtctgca aaatgtgaaa aatatttcct 60661 gcctcataag gttgccctaa ggattaaatg aatgaatggg tatgatgctt agaacagtga 60721 ttggcatcca gtatgtgccc tcgaggcctc ttaattatta ctggattgct catagtgcat 60781 gttctttgtg ggctaactct agcgtcaata aaaatαttaa gactgagttg cagctgggca EPI-109 1120

60841 tggtggctca tgcctgtaat cccagcattc taggaggctg aggcaggagg atcgcttgag 60901 cccaggagtt cgagaccagc ctgggcaaca tagtgtgatc ttgtatctat aaaaataaac 60961 aaaattagct tggtgtggtg gcgcctgtag tccccagcca cttggagggg tgaggtgaga 61021 ggattgcttg agcccgggat gatccaggct gcagtgagcc atgatcgtgc cactgcactc 61081 cagcctgggc gacagagtga gaccctgtct cacaacaaca acagcaacaa aaaggctgag 61141 ctgcaccatg cttgacccag tttcttaaaa ttgttgtcaa agcttcattc actccatggt 61201 gctatagagc acaagatttt atttggtgag atggtgcttt catgaattcc cccaacagag 61261 ccaagctctc catctagtgg acagggaagc tagcagcaaa ccttcccttc actacaaaac 61321 ttcattgctt ggccaaaaag agagttaatt caatgtagac atctatgtag gcaattaaaa 61381 acctattgat gtataaaaca gtttgcattc atggagggca actaaataca ttctaggact 61441 ttataaaaga tcacttttta tttatgcaca gggtggaaca agatggatta tcaagtgtca 61501 agtccaatct atgacatcaa ttattataca tcggagccct gccaaaaaat caatgtgaag 61561 caaatcgcag cccgcctcct gcctccgctc tactcactgg tgttcatctt tggttttgtg 61621 ggcaacatgc tggtcatcct catcctgata aactgcaaaa ggctgaagag catgactgac 61681 atctacctgc tcaacctggc catctctgac ctgtttttcc ttcttactgt ccccttctgg 61741 gctcactatg ctgccgccca gtgggacttt ggaaatacaa tgtgtcaact cttgacaggg 61801 ctctatttta taggcttctt ctctggaatc ttcttcatca tcctcctgac aatcgatagg 61861 tacctggctg tcgtccatgc tgtgtttgct ttaaaagcca ggacggtcac ctttggggtg 61921 gtgacaagtg tgatcacttg ggtggtggct gtgtttgcgt ctctcccagg aatcatcttt 61981 accagatctc aaaaagaagg tcttcattac acctgcagct ctcattttcc atacagtcag 62041 tatcaattct ggaagaattt ccagacatta aagatagtca tcttggggct ggtcctgccg 62101 ctgcttgtca tggtcatctg ctactcggga atcctaaaaa ctctgcttcg gtgtcgaaat 62161 gagaagaaga ggcacagggc tgtgaggctt atcttcacca tcatgattgt ttattttctc 62221 ttctgggctc cctacaacat tgtccttctc ctgaacacct tccaggaatt ctttggcctg 62281 aataattgca gtagctctaa caggttggac caagctatgc aggtgacaga gactcttggg 62341 atgacgcact gctgcatcaa ccccatcatc tatgcctttg tcggggagaa gttcagaaac 62401 tacctcttag tcttcttcca aaagcacatt gccaaacgct tctgcaaatg ctgttctatt 62461 ttccagcaag aggctcccga gcgagcaagc tcagtttaca cccgatccac tggggagcag 62521 gaaatatctg tgggcttgtg acacggactc aagtgggctg gtgacccagt cagagttgtg 62581 cacatggctt agttttcata cacagcctgg gctgggggtg gggtgggaga ggtctttttt 62641 aaaaggaagt tactgttata gagggtctaa gattcatcca tttatttggc atctgtttaa 62701 agtagattag atcttttaag cccatcaatt atagaaagcc aaatcaaaat atgttgatga 62761 aaaatagcaa cctttttatc tccccttcac atgcatcaag ttattgacaa actctccctt 62821 cactccgaaa gttccttatg tatatttaaa agaaagcctc agagaattgc tgattcttga 62881 gtttagtgat ctgaacagaa ataccaaaat tatttcagaa atgtacaact ttttacctag 62941 tacaaggcaa catataggtt gtaaatgtgt ttaaaacagg tctttgtctt gctatgggga 63001 gaaaagacat gaatatgatt agtaaagaaa tgacactttt catgtgtgat ttcccctcca 63061 aggtatggtt aataagtttc actgacttag aaccaggcga gagacttgtg gcctgggaga 63121 gctggggaag cttcttaaat gagaaggaat ttgagttgga tcatctattg ctggcaaaga 63181 cagaagcctc actgcaagca ctgcatgggc aagcttggct gtagaaggag acagagctgg 63241 ttgggaagac atggggagga aggacaaggc tagatcatga agaaccttga cggcattgct 63301 ccgtctaagt catgagctga gcagggagat cctggttggt gttgcagaag gtttactctg 63361 tggccaaagg agggtcagga aggatgagca tttagggcaa ggagaccacc aacagccctc 63421 aggtcagggt gaggatggcc tctgctaagc tcaaggcgtg aggatgggaa ggagggaggt 63481 attcgtaagg atgggaagga gggaggtatt cgtgcagcat atgaggatgc agagtcagca 63541 gaactggggt ggatttggtt tggaagtgag ggtcagagag gagtcagaga gaatccctag 63601 tcttcaagca gattggagaa acccttgaaa agacatcaag cacagaagga ggaggaggag 63661 gtttaggtca agaagaagat ggattggtgt aaaaggatgg gtctggtttg cagagcttga 63721 acacagtctc acccagactc caggctgtct ttcactgaat gcttctgact tcatagattt 63781 ccttcccatc ccagctgaaa tactgagggg tctccaggag gagactagat ttatgaatac 63841 acgaggtatg aggtctagga acatacttca gctcacacat gagatctagg tgaggattga 63901 ttacctagta gtcatttcat gggttgttgg gaggattcta tgaggcaacc acaggcagca 63961 tttagcacat actacacatt caataagcat caaactctta gttactcatt cagggatagc 64021 actgagcaaa gcattgagca aaggggtccc atagaggtga gggaagcctg aaaaactaag 64081 atgctgcctg cccagtgcac acaagtgtag gtatcatttt ctgcatttaa ccgtcaatag 64141 gcaaaggggg gaagggacat attcatttgg aaataagctg ccttgagcct taaaacccac 64201 aaaagtacaa tttaccagcc tccgtatttc agactgaatg ggggtggggg gggcgcctta 64261 ggtacttatt ccagatgcct tctccagaca aaccagaagc aacagaaaaa atcgtctctc 64321 cctccctttg aaatgaatat accccttagt gtttgggtat attcatttca aagggagaga 64381 gagaggtttt tttctgttct ttctcatatg attgtgcaca tacttgagac tgttttgaat 64441 ttgggggatg gctaaaacca tcatagtaca ggtaaggtga gggaatagta agtggtgaga 64501 actactcagg gaatgaaggt gtcagaataa taagaggtgc tactgacttt ctcagcctct 64561 gaatatgaac ggtgagcatt gtggctgtca gcaggaagca acgaagggaa atgtctttcc 64621 ttttgctctt aagttgtgga gagtgcaaca gtagcatagg accctaccct ctgggccaag 64681 tcaaagacat tctgacatct tagtatttgc atattcttat gtatgtgaaa gttacaaatt 64741 gcttgaaaga aaatatgcat ctaataaaaa acaccttcta aaataattca ttatattctt 64801 gctctttcag tcaagtgtac atttagagaa tagcacataa aactgccaga gcattttata 64861 agcagctgtt ttcttcctta gtgtgtgtgc atgtgtgtgt gatgtataca aagagagaga 64921 taattgtatt tttgtatttt cttttaaata atttttaaaa ttgacccttt tcctgagaca 64981 aattgccaga atagtttgta tttagagatg gtacctctaa gagtaaggtt gctggttgct 65041 gagcaattga cttgaaaact tttaaaattc aaattttaat tccactactc aaaagaattg 65101 ccatgtttta aaaaagagaa ttggtgccat aagttagttg tctatgtttg aaaatgaaga 65161 agatatgcaa cgtcatggcc tggtcactta cccgcagccc tgagttgtag gcacatcata 65221 tgtgagaatg aggatgcttt tatttcattt aaaatccctc cccaaaactt ggctctaatt 65281 gcagtcatga caatcatgta catttggatt tatgtgcacg agtctcttac cctgagagag EPI-109 1 121

65341 gacaggtgct acaggtggag gggacccgtc tgggtcacgt tcacattttg aacatgctgg 65401 ttttcagtca ctgcacactc atctcccagc gcaggtcatg ggcagcagat gcaaaagctg 65461 cccgtggtcc tatttggagg tgcatgaaat gagcagaaga cagaatagct tgatctgact 65521 agaagggcag cttgtcccta ccaagacttg aaggattgcc tttcatctgt tagggtaaaa 65581 ggtagaatga accaaggaag ggcaggaggg ggctggggtt agggtagaag gaaggggcca 65641 tggagaaggg agatccatcc cataggagga aggcagtgcg gcagggaggt ttgaaggtat 65701 cagcttttgt ggctgacata catgcagtca tgtcaattgc tcgtttttcc ttttccatct 65761 tattaaatgt cttccaatgt tagcacgaag aaaagctatt tgcagtgttg ccagcctttc 65821 cagagcccgt ccccattacc tccccaggcc catgccttta ctccttggag tttcaactca 65881 cgaccttcag gatctgactt tattcaccaa ctctggggtg aacgtacctt ctgtctccac 65941 ccagaggtct ctatcaaaga ggagattgca tgccatggat aaagtcaaag tagaggtgac 66001 tgtccttagg aagagtaatg tgaaaattca taaactggga ttctgtttac attttgtact 66061 ccaggggttc ttagtttaaa tcgctctgaa taaattaaga tgcaatggca tttcaactgt 66121 tatgattaaa tttacaaatc atttattttc tatcacgggg agagatagag ctccaaatgc 66181 aaacataact gctcaagtgt taacacttat aatgaaaaca taagaattac caccaactac 66241 cctgggggct agaagcagaa atgtgaacca gaaaacaaat catgaacttt cctttttttt 66301 tttgagatgg agtctcgctc tgttgcccag gctggagtgc aatggtgcga tctcggctca 66361 ctgcaaccac tgcctcccgg gttcaagcaa ttctcctgcc tcagcctcct gagtagctgg 66421 gactacaggc atgcaccacc acgcctgggt aattttttgt atttttagta gagacagggt 66481 ttcaccgtat tagccaggat gctctcgatc tcctgacctc gtgatctgcc cgcctcggcc 66541 tcccaccgaa gtgctgggat tacaggcatg agccactgtg cccggccaac aaatcatgaa 66601 ctttctaact gcagttcctt gtagcttgtt aacacatcca cttacttatt gtcagagtac 66661 gtggagattt tccacaaccc tcggggataa ggctgaacag aagaggcaaa aacgtgaaaa 66721 catttcgata gctcctatac tttgaaataa aattcactgt aaaagttgct tgtatttttc 66781 caaaacagag tcaaccctta atatttaaga ttctgtatac aaatacatat ttttatataa 66841 ttaatatata ttgtcatatg acatatatct ttatattaat atgcatgcat ataatatata 66901 tttccttcct aattttctat aagcaatttt acaagactga cttctatttg cctccttatt 66961 gttactacgt ggtttgataa tccgttttgt gtcattgtga ttctgtcatg ttttggggac 67021 ttatttttgt ttctctgggt ggtcactagt ttttttaaag cattcatgga agagtgtgaa 67081 tcttttacaa gctaggaagc catggcaagc cttgggtcat actgcccccg cgaggccaca 67141 ttggcaaacc agcaagggtg ttcaacttcc agacttggcc atggagaaga catacgagga 67201 ggcttttcac attcagctct ttaatgtttg tctctgccgg caccatccca gttgtgaata 67261 agaggtattt ccacagcggc tcagggtagg tagtgcacag ctcacattca tcatttctga 67321 aaaccgagag gagtctccat tcggggtaca ggttgatgcc tgtcgtggaa tgaaggttcc 67381 aacacccaga ccaatctctg cagtgtgctg ctctcatgag cttgcaacaa gatcagaaaa 67441 tgttttgtga ctaagcattt ttcatattgc ataaaatgct tcaagctcct cccttgtttc 67501 tctctataat cctgtatatc tgatgattgt gggtaccaag tgtttgaaat aatcaaatgt 67561 gatttgatgt tggtaaattt cttttttttt ttttttttac ttctattttt tttattatac 67621 tttaagtttt agggtacatg tgcacattgt gcaggttagt tacatatgta tacatgtgcc 67681 atgctggtgc actgcaccca ctaactcgtc atctagcatt aggtatatct cccaatgcta 67741 tccctccccc ctccccccac cccaccacag tccccaaagt gtgatattcc ccttcctatg 67801 tccatgtgat ctcattgttc aattcccacc tatgagtgag aatatgcggt gtttggtttt 67861 ttgttcttgc gatagtttac tgagaatgat ggtttccaat ttcatccatg tccctacaaa 67921 ggacatgaac atagcaaaga cttggaacca acccaaatgt ccaacaatga tagactggat 67981 taagaaaatg tggcacatat acaccatggt aaatttcttt atcattcgca ctctcctttc 68041 tctattattg ttattgtaac tgaaccgcag attagtcact cattgcttgc agaatccaat 68101 taacaagagc gaggtcagat ataaagaaaa tgatttattc caaacctcct tcagggaaga 68161 ggtgcagcct cctgcctcta aatgcactgc ttcgccaggc gtggtggctc acacctgtaa 68221 tcccagcact ttgggagacc gaggagggca gatcacttaa ggtcaggagt tcaagaccgg 68281 cctggccaat atagtgaaac ccctgcctct actaaaaata caaaaaatta gccagacgtg 68341 gtggcgggtg cttgtaatcc cagctactcg ggaggctgag gcaggagaat cgcttgaacc 68401 tgggaggtgg aagttgcagt gagctgacat ctagccactg cactccagcc tgggtgacag 68461 agtgagactc tgtctcaaaa taaataaata aataaataaa taaataaata gtaaatgcac 68521 tgctttgctt ttggagcaga aagcaggcac tttgaaaagg caggggagga agtgagcaag 68581 ggcagggggt ctgcacactg gcatggtgcc tgatctatcc aggcagttga attggcactt 68641 tcataggcag aaataagttg aaaaagtggc ctaaaactct ctaggtggga gtggatagtg 68701 ggcatgcctt caacctgcct ttctggaggg tgagttccat ggcaaccccc tgaagggtga 68761 gagttccatg gagatcatgc tttggtctgt aaatcagctg ttaactctct agaaagttct 68821 gtcttggagc atatagttag atgaacttgc cctgtaaaga atgtctggtg aaggggaagt 68881 aaaaggtgag atttgcattt ctaaagggct aagtagaacg tggggtacaa gaggaaagga 68941 gaaaagagaa aataatttaa aaaataattg taacttattc ccttttactt agaaaaaagg 69001 gaatactcag ttacattatc acctcgttta catcaaaccc tcttatggaa tcctatggtt 69061 tgaaaacaaa aaggttgttg aggaccagtg agcccaaccc ctttgcttta taaatgaaga 69121 gcattgcctg ccctaagccc cagagactct gatgtcgtgg gtctggagtg ggctccaaca 69181 gcggcatgtt ttgatggtgc ttcccagtgg cacgccagcg atgagccttt gagtagggaa 69241 agtaggagca ctcgtgactc ccttcacgat cagcacctgt gtgctaataa attcacaaaa 69301 gccaacatat tggagtcact cagggagttt tacaaatagt gaggttaaat ccaacctcaa 69361 atagttctga ttcgatctgc ctgcattgct gccctgtggt tccccactgt agaagctccc 69421 caggtgattc taagtgtagc caagtctgag aaatactgcc taaagcctgt tggactgaca 69481 gcaagggctg ttgtctgagc aagactttgc ctggcctggg gtggcatgtg caccaggaag 69541 agtctcaact ttcataacag aacattcccc aagctggttt ttttaaagca tgtgaatcta 69601 gacttcattg gcaataccaa agatctgtat ttgaggctcc aagtatttca ctttcatttt 69661 tggttttggg ttatgttttc acccttcctt tccaagtgaa aagtaaacag aagtgggatg 69721 tctggcgccc atgctgagct tggcaacttc aaattcaata gagaagaagt ctcttgtata 69781 gaaaagggcc tgtctgagat gtttctcaaa taaatataga ttttgcttat gtggctaaag EPI-109 1122

69841 gattcttctc cccccatttc cttatccctg cagtgagcca tccttcttaa ctctttccat 69901 gaaagcatta ttcctgaaga actgggaact catgccagcc ctgatcaggc aatgataatt 69961 ctgcagagaa ttagaattta gatttaaatt gtcaactctt atacatcctg gcatatggtt 70021 taaacacatg tacacacaca caaacacctc ctactattta ctgaagagca gatatctgat 70081 aacttaatct ttttggtttt gagtcaagac aattcctcct tttgaaactg cataccgctg 70141 aatataataa aatgtaatta agattaaaaa taagaaacta atgggagaat ttcaatattg 70201 tctctgttca ctttaaaatt cctctactta ggtttactgc cattaccaaa gactattcaa 70261 aaatcctttt taggagaatc ctaatggttt cctgacatat aatcaaataa ggactctgtt 70321 gattggctaa ctcaatcttc ctgtgccaaa aagcagagcc cagcagagaa gagggcaggg 70381 acttgaaagt cagactgact cgagttccag ccttggggct gtgggagctt gggcaagtga 70441 cttaacgtct ctggctctca ggatctaaaa ggatttccag tagtaatttg gggtgttact 70501 gatacaggag ctaaaaagaa attatttagg tggttagtga gggtcagaga gtcctcggta 70561 agatttgcct tttaacaaaa agcagcccca aaatcatttg tttgctaaca aagagaagcc 70621 tgtaaaattg agctgcagac atagataagc aagctggaag cttgcacggg tgaatgccgg 70681 cagctgtgcc aataggaaaa ggctatctgg gggccaggca tgttcaacat ggattctcca 70741 tcttcccttt tctttgtcaa ccaagtgtac agtaaaggaa caggcaacat ggcacgggcc 70801 aggtagagaa cccttctgca taataaaaga ttagggtgag atggccagct tcttcccgtg 70861 ctatgtaaat ggcatacctg gtccaaccag tcttttgggc cctgtgtaaa tcagacaccg 70921 cctcctcaag ttagtctata aaaccccatg cattttaccg tgaaactggg agatccactc 70981 ggaaccccct cctgcacgag agaccttttc tcttttgcct attacacttc cgctcttaaa 71041 ctcactgctc atgtgttagc atccttgatt tccttggcat gaggcaatga accttgtgta 71101 ttaccccata caaatgatgc tgcttcatta ctaatagcaa cctgacaggg ttgtgttggg 71161 gtataaatta tctagaccag ggagatccaa tataattttt ttgtaatgac gggaatgctt 71221 tgtatctgca tcatccaaaa tggtagccac caggccaggg tgaaatgtgg ccagtgtgac 71281 tgaggaactg aatgttttcc atgatttaat ttaaatgtgg ccaatggcta ctgtaggaga 71341 cagtgtgagt ctggcatatt ataaataata aatattaata taatttgaac tttggcatca 71401 gtgtttccta gatttgaatt actatgcaag ttgcttactg tttccaagcc tcagctttct 71461 aatctgtaat tggggctaat aatagtatct gccttacagg tttgttcaga ggataaatga 71521 gaaattgcat gttgagggct taacacagtg cctggcacat aaaagctctg gtaacagtta 71581 gccactttaa taatttgcta ataatggcta tttcttcttc agattaggat gtgctccccc 71641 aaacagtgca cttagacata gcgggcaatc cagctcactc tctgcagtga gagagaagca 71701 ctggccgacc agagtcagcc aggggctcat gggtatgaaa tcaacagcat gattttgtaa 71761 gtaatggatg gaaagggcct cacaacttta tggcactgtg ttcaatttgc ttggtcttct 71821 gtagctcctt ttgaaagcct tttagggtgg attaacctgc taccaataat tctggtcaga 71881 tgtagactcc atagctcaaa gcaaactgag agagtgaggg cagcaggcca attccccacc 71941 ccttccttct ggactctgac agaagcttac actcaaggaa gagcaagtag gaattaacgt 72001 gttaagagct aggtaagcaa aacccaatga gaagttctgg caaagcccca tgggcagggg 72061 tggcttaggc acaggaaaca agtaggattt cataccacgc gcctcagtct acttccgggg 72121 ccctcatcct cagctgtgcc tatgcaaagg agagcaacca ataaacccca ccgccactct 72181 cctactgtgg aggccaggga tggccagggg taagagaggg atgggaagtg tttcctccag 72241 ccgtcctctg agaaggagag gaaactgggc agagcttctg tcctccttca agcagaaaca 72301 gaaacaaaag aaacccctaa gggggttctt acttcccctc tagttcagtt gtgcactaac 72361 catctgcagc tcaacattca gcattcattc attgattcag caaacattga aggagggcca 72421 gctatgtgcc agatgccaac tcatgccatg aaagagagtc cctgtcctta tgaaattcac 72481 tatttagaga gaaaagcaag caaaaaggca aagtttgaaa agtactgttg aagtggcatc 72541 attgtctggg gtgaatacct gaggtttgtg gtctcacgcc aagggaatca aggactcagg 72601 cacacaagaa gtgagtttaa gagcagaggt ttaataggca aaagaaagag aaaaaagaat 72661 agctctcttg cctgcacaga gagaggggca cctgagtgga tcttcctgtt ttgtggtgaa 72721 atgcaaggca ttttatagac gagcttgagg aagtggtgtc tgatttactt aggacccgag 72781 agattggtca gaccaggtgt gatgtttaca tagcatacaa agaagctggc catcccatcc 72841 taatctttta ttacgcagac ggggtctata cctggctggt gccatgttgt ctgttcctta 72901 ctgtacacgt ggttgacaaa gaaaagggaa gatgaagaat ccatgttgaa catgcctggc 72961 ccccagatag tcttttccta ttggcacagc tgccggcatt cactcttgca agcttccaga 73021 ttgcttatct atgtctgcag cccaatttta caggttgctc tttgctagaa aagaaatgat 73081 ttgggggctg cttttcatta aaaggaaaac cttaccaagg ttaaaaagaa aaaaatttct 73141 ttttaatgcc tatgttactg tgaacagtgt cgggataagg ctctgagagc cagatgagga 73201 tgagttatcc aatccaagga tgggggtctg gaggaaaaaa tcctagagag cattgctgca 73261 gttgaataag gattagttag aagctactga gtggagcata ggagtaggaa ctcttatgca 73321 aatgtgcaga ggtgaaataa agcaaggtat agtccaggtg cctaaagtag cacagctgac 73381 ttgagataga tgatagatag gtagatagat ggatagggta catagatgat agatagatag 73441 atagatagat agatagatag atagatagat agacagacag acagacactg gtgtgagtgt 73501 gggtgtgtgt gtctggctgc gtgcatgcat tcctcctgca ggagatcagg agcagtgggc 73561 agtatggagt gacaagaaga ttgggaggta ctccttctag ccctcccctc tgctctgccc 73621 tccactggag cagaagcaaa gcatatggtg aaggggaaca aggagtctcc ccagcacagt 73681 acccgagtgc attagctatt tatcactcca cagtccccat tcacgtgtta attcagcatt 73741 tattgaatgc ttactgtttg caatgtctat gtcaagctgt caagtgtagt ttttattcta 73801 caggccacag gcacccccta actgtgttaa acaagatggt agtattgaga caggaataat 73861 aagggtggtc acaggagaat ggaagattcc aggcagcagt ttgactagta aaaaaggaaa 73921 ctgttgaaat agctgcataa tccaggggtc aataagaacc tgagaaccag ggtgtgagcc 73981 aaggctggtt aaaagcaact ggatccaata tggtgctgag tttctcctag gttttgcctg 74041 gaacctcatt atatgctcaa taacatacca aatcacacac ccaccagggc cattccattt 74101 cctggaacac tcatgtttgg tgtaaaaatg ggtggcacca cagctctgag aaatctttac 74161 ctttttcagg aaacttcatg aatattccat cctttggtta aagaaaccca taatgtagaa 74221 gccccaaacc ctactgggcg caactctctc tctcttgagt atgcctgcac ttccctttat 74281 tatttattta tttatttatt atttatttat ttatttttta gatggagtct ggctctgtca EPI-109 1 123

74341 cccaggctgg agtgcagtgg cgcagtctca gctcactgca agctctgcct ccagggttca 74401 ggccattctc ctgcctcagc ctcctgagca gcagggacta caggcgccca ccacaacgcc 74461 tagctaattt tttgtatttt cagtagagat ggggtttcac catattttat tttatttttg 74521 agacagggtc tcactttgtt ggctcgctgc aacctctgcc tcccaggctc aagcaatcct 74581 ccaacctcag ccccccaagt agctgggagg acagacgtgc accaccacac ctggctaata 74641 ttttgtattt ttttttgtag agacagggtc ttgccatgtt ccccaggctg gtcttgaact 74701 cctggactca ggtgatcagc ctgcctccac cttccaaagt gctaggatta caggaatgag 74761 ccaccccacc cgaccacact cccatttctt gagtgtgtgc attttgctct gcaataaatc 74821 tctctacttt cacttttctc tgactcgtcc ttgaattcct tcttgtgaca gcgtcaacag 74881 cctggacacc aggtgcagtc aacgtctcac cagtgtttag ggacctcccc taatccactg 74941 gtatcagcat gatcagactt gctttttcag aaaaagcctt ctgtccatag accaaaggga 75001 agtgactcag agaaggggca ggaggaatca caagctccct gcctgaccag gcctggacta 75061 tggcagagac agtgagatgg tgagaaagca agggtagaca gccagccaaa tccagaatat 75121 agaaagttct acaggaaaag gtggggccaa ggtgggacag ggggaaagga attgttgcac 75181 attaacagtg caatgcagag cactggtctt gtttatgtcc aggttagaac aaaccaatga 75241 gaaagcacat ctttgagaca actggagaaa tttgaacact gactagatat aatattatgt 75301 taattatgct ttaatttggg gtacaataat gcttttgtag ctatttctaa agagtcctta 75361 tctcttaagg atacactcta aaatactagt ggattaagtt atatgatgtt tagactcttt 75421 ttaaaataat ccagtggggt gagaggcaga gggaagggag aggagcatag aggaaacagt 75481 gttggccata tgtttgtaat tgttaaaact gagtgatggg aatatggaga tttaacatat 75541 taatactatt ttctgcccat gtaatatttg aatattttca taataaaatt gagagagaga 75601 taaagaaaga aaagagaaaa gaagagaaga gagaagagat aagggaagtg gaggaaaaag 75661 agctttcttc aaggaccatt gtggtggaca caaatgaaag ataccccctt cctactatga 75721 attctaggtg tgtactaccc aagatgagtc aatcggatcc tagcttccag aaatcgtgag 75781 catgatgcag ccctacagac gcagtgccct ggaaaggaga cccatgacca tccaaggaag 75841 atgtcccatc acagaactgc cctgggtcat gtgttttcca agtccacatg tccggtagtt 75901 ccttctttcc tatgaccaat gccaccagtc ttccagcact gtcctttatt gctaggcaaa 75961 cctgagccat cctcttcttc ttgcaacttg tgcctgaagt aacatggaca caaagtcccc 76021 acttttccca cattctcaga atgaagtagt tctccctcca cactttaggt gctagaggca 76081 agtggattgc ttgagctcaa gagttcaaga ccagcctgag caacatggca aaaccccgtc 76141 tctacaaaaa atacaaaaat taactggggg tggtggtgtg cacctgcagt cccagctact 76201 caggaggcag agaaggagga tttcttgagc cctgaaggtg gttgtgttac gtgcattcat 76261 gttaagagac caccaaacag gctttgtgtg agcaattaag ctttttaatc atgtgggtgc 76321 aggcagactg agtctgaaaa aagagtcagc aaagggagat agggatgggg cggttttata 76381 ggatttgtgt aggtagtgga aaattacagt taaagggggt tgtcctcttg cgggtacagg 76441 cgggggtcac aaggtgctca gtggggagct cctgagattt attgtccagg agaaggaatg 76501 tcacaaggtc aactgatcag ttagggtggg gcaggaacaa attacaatgg tggaatgtca 76561 tcagttaagg caggaactgg gtattttcac ttctttgtgg ttcttcagtt gcttcaggcc 76621 atctggatgt ataagcgcag gtcacagggg atatgatggc ttagctcggg ctcagaggcc 76681 tgacattcct gtcttcttat attaataaga aaaacaaaac aaaatagtga tgaaatgttg 76741 gggcagcgaa aatttttggg ggtggtatgg agagataatg ggtgatgttt ctcagggctg 76801 cttcaagcag gattaggggt gacacaggaa cctagagagt gagagagatt aaactgaaga 76861 aagattttgt ggtaaggggt gatattgtgg ggttgttaga aagagcaatt ctcatataga 76921 atgattggta atggcctgga tgcagttttg tatgaattga gaaactaaac ggaagacaca 76981 aggtctgaat aagagaagga gaaaaacagg cattaaagga ctaagaactg ggaggaccca 77041 ggacatccaa ttagagagtg cccaaggggg ttcagcataa ttatttgctt ggttggtgag 77101 tttttggtct ccatccttga gtttttttta tgttgtcata tgccaggcca gattgattta 77161 ggtaaaaaca acactcttca tttaaaaata tacagagttc tcctttctca gcagtgagta 77221 agtcaaggcc tcagcagttt tggaggaaag agaaatgcaa aggaagcaat tgtttgttaa 77281 gaaggattag aaatggctag gagagagtga gtgagattga tagtgtggtg gagatagctg 77341 aggagaggta gagggtggca taagaatggg aacgagaata agagtgagta taaaagtaaa 77401 gaatagaact tcatcagggt gaaagtattg gagggtgccc tgtcagcaaa gatcatctgt 77461 ccactccaag agggagtcaa gagtggcgga ttggggatag taccaggaga tatccactat 77521 gatggtttgg aggaaaagtg taaactggca gtgtaaacag gggcagggca tttatgagtc 77581 attgagaatg gtgaatagga gtatgactag acagaagata gtggagatga caaattttgg 77641 gggcacagtc caaatagtgg gggtgactgc gtagagctct gttgcaaaaa gtagggtaag 77701 gataaataga cttaatagaa tgaagagatg tattaggctc ataagggtta ttattgttct 77761 tcagaaatgc gagtgagttt aagggaagta ggggtgagta cttgcgactt ccagaaggaa 77821 gaggagagat caggctggct gtctgatggg cacagcttta ttctggaaca gtgaatccaa 77881 tggggagggt cgtgcagacg gatggcagtt ggggtgctat aaatgaccag gtagggtcca 77941 gtccatcaaa gctgtagagt gtgaggggtc agacttgaca aggactgatt gcccagctaa 78001 ggtatcttca catggctggg agtttggagg aggcaagaga agattagcag cctggcgaat 78061 ttcctgtcta gcctgctgga ggactggaag ataaaggcaa caggtcgtgg gcctggatcc 78121 tgtgtgagga ctctagcagc acagccttgt atttcagctg tgtgtaagga aaaaggatgg 78181 gacgagtcgg ggagtgctag tgtgggagct gtctccaggt cctttttgag agagtgaaag 78241 gaagaatggg gaaaagactt atggtctatg ggattagtta aattaccctt tgtgagctag 78301 taaagtggtt tgattaggat agcaaagccc ggtatccaaa gttggaaata tccaacaatg 78361 cctaagaagg aagggagttg ttgtttggtg gtgggggttg gggtctggga gattaactga 78421 acagagtctg caggaagggt atgtgtatgt tgatggagca ttataccaag ataggtaatg 78481 ctaggggaag aaatttgtgc ctcagagggc aatactttgt acccctttga gtaaagatgt 78541 tgaagaagca ggctagtgtc ctgctgggaa gattggtaag aggggctgca aagaagaaga 78601 tcatcaacat attgaataag gtgggaggta gatgggtgaa aagaaagcag atcatgagaa 78661 agggcctggc caaagtaatg tgggctgtcc ctgaagcctt ggggtagaaa aatccaggtg 78721 agttgttggg actggtgggt gtcagagtca gtccaagtaa ggcaaaaaga ggctgggagg 78781 agggatgcaa ggggatagta aagaaggcat ctttgaggtc gataacagaa tagagttgtg EPI-109 1 124

78841 gaagggtgta ttgaagatag gagggtgtac gggtttggca ctataggatg gatgggaagg 78901 acgatttgat caacaagacg aagatcctga acaaacctgt aagacttgtc cggtttctgg 78961 acgggtagga taggggagtt gtaaggagaa tttgtaggct ttaagaggcc atgttgaaac 79021 aggcaggtga taacaggctt taaccctttt aaagcctgct gtgggatggg atattggcat 79081 tgagcggggt aagggtgatt acattttaat gggatgataa ggggtgcatg atcggttgcc 79141 aaggtaggag tagaggtttc ttatacttgt ggattaaggt ggggagatac aaggggagga 79201 tgtgaaacag gtcttgagtt gggtaaaagt gcagcaaaga gatgtggctg cagcccagga 79261 atactcaggg aagcagataa tttggttaaa atgtctcagc ctattaagga agctggacag 79321 gtggggataa ctaaaaaagt gcataaaaga atgttgtcca agttggcacc agagtggggg 79381 agttttaagc ggtttagaag cctcgccgac aatacccaca acagttatgg aggcaaggga 79441 aacaggccct tgaaaagaaa gtaatgtgga gtgggtagcc tccgtattga ttaagaaggg 79501 gacagactta ccctccactg taagagttac ccaaagcatc tgtgatggtc caggaggctt 79561 ctgaggtgat caggcagtgt cagtcttcag ctgctaagct gagaagatct gggaaggagt 79621 cagtcagaga gccttgggcc agagttccag gggctctggg agtggttgcc aggcaagttg 79681 aacagtctga tttccagtgg ggtctcgcac agatgggaca ttccttggcc cagtggccag 79741 atttccggca cttgaaggaa gatcctgggg gaggaggtcc tggagaaatg cctggcccct 79801 gcagtttagg tgttttgaag ttcttgtgtg ctggagatgt ggctggggtt tctcttacag 79861 cggaggcaag taattgcaac tcagaaatat gttgtcactt ggctgcctct tttctattat 79921 tgtacacctt aaggcgaggg taattaaatc ctgttgtggg gtttgagggc tggaatctaa 79981 tttttggagc tttttctaat gtcaggagca gattgggtaa taaaatgcat attgagaata 80041 agacggcctt ctggcacctc tgggtctaga gaggtaaagt gtctaagggt tgttgccaaa 80101 caggccatgg actcagctgg gttttcatat ttgatgaaaa agagcctaaa cgctaactga 80161 tttgggagag gtcagctaaa gaaaaaggag cattaacctt gactatgcct ttagctctag 80221 ccacctctct aagaggaaat tgttgggccg gtgggggagg gctagttgtg gaacgaaact 80281 gtaagccaga ccaggtgtga ggagagaagg tgaccaaagg tttatagggt aggggagcag 80341 aggctgggga agaattggga cctggctagg cctagcgagg aacagcctgg ggaggagggg 80401 agaaatcaga tgggtccgta gaaaaggagg attcaaagga ctcagagctt ggggtggaga 80461 ctgaaggaac agacaggaga gaaagaggaa agatttggga tgagtcacat tgggagcaga 80521 gactagagag ggactgatgt gtaaagaatg cctggacgtc aggcacctca gaccatttgc 80581 ccattttacg acaaaaatta tctagatctt gtaggatgga taaatcgaaa gtgtcattct 80641 ctggccactt ggaactattg tcaagtttgt attggggcca agcagtatta cagaagaaaa 80701 taagatgttt aggtttttaa aagagtgcat aaaagaatgt tgtccaagtc catgcccttc 80761 ttaatcaata tgggagctac ccactccaca ttaccttctt ttcaagggcc tgtttccctt 80821 gcctccataa ctgttgtggg tattgatggc caggcttata agccccttaa aattacccca 80881 ctctggtgcc aacttggaga ggtcaggtgt tagtcaaagg tgttttaagt tttaagaaca 80941 caggctaagg gagaagaagg gggaatgaag cgtggaaggt tgcccatagt gaaagaggta 81001 agtttaaaga gaaaggtaga gacatggaga aggggggagg tgagcagccc tgggctgtca 81061 tgtgggttag cagccaaagc tggtgtccca gcaattgact taccaccaag ggaatgtggg 81121 tgaatgacca aggcaggcat ccccccggtg atcagacacc aaatggaatg tgggtgaaag 81181 atcaaggtag gtgtccccat gatgatcaga caccaaagga aggctgtctt cccaaatcca 81241 tgatccatgt tggagttttt gagttcatgg ataaaatgtg tctcctttgt ctctactaga 81301 gaggaaaaag aactggaatt tgaaggacag ggagattgaa gggtagggag agaggctgaa 81361 gaagagagtg aggagaccgc ttacccggtt tgaaattggt gagatgttcc ttgggctggt 81421 ctgaggacct gaggtcgtag gtggatcttc tcatggagtg agggtgagga gaggggacca 81481 atctcccgaa ggagtcaccc tgtccggggt cttcggcacc aaatgttatg cgcatccata 81541 tgaagagacc accaaacagg ctttgtgtga gcaataaagc tttttaatca tgtgggtgca 81601 ggcagactga gtctgaaaaa ggagtcagca atgggagtta gggttggggt ggttctatag 81661 gatttgggta ggtaatggaa aattacagtt aaagggggtt gtcctcttgc aggcaagggc 81721 aggggtcaca aggtgctcgg tggggagttc ctgagactca ctgtccagaa ggaatgtcac 81781 aaggtcaatt gatcagttgg ggtggggcag gaacaaatta caatggtgga atgtcatcag 81841 ttaaggcagg agcggcctat tttcacttct tttgtggttc ttcagttgct tcaggcaatc 81901 tggatgtata tgtgcaggtc acagaggata tgatggctta gcttggactc agaggcctga 81961 caggttgctg cagtgagcca agatcacact actgcactcc tgcctgggca acagagccac 82021 aaaaaaaaaa aaaaagaaaa gaaaagaaaa aaaaagaaga agaaaaaaaa attttttttc 82081 caccaagaat ttagtaaaaa attataggga aaagtgtcac taattcaagg gaattgcact 82141 gaaaattatt cattcattca acagatattt attgagaagc aagtatgctg gtgctagggt 82201 tacaacagcg cacaaattct tgtattcaag gaatgaggta agagtatgca gataggagcc 82261 agagaggtca agaggcaatt gcaacataga gtgacacgtg ctccagaaca cataggaggg 82321 cttccaggcc ccatgctggg ctatcagagc tggcttcctg caggtggtgt ggctcagcta 82381 aaacctgaga accaagaatg agccttctga tatctcaggg ttaaatcggc acaaatgaaa 82441 ccattttata accaaacaac attttccctc ctgaactgca ctttttctag aacccattta 82501 atccttccta acatgttcaa tccagccccg tgatttttca gtcaaatgca agatgcgtag 82561 gattcctttt ctgttcagtg ctccccagcc aatctttttc ccttctccca ccccacagtt 82621 actaattcca gcgtttcagt tctcagcaga ggatgacagt tccaccagga gacatcagtg 82681 ttatctggag acattttagt tgtcccagct gagggcacag tgctgctggc atctagtggg 82741 tgaaggtcag gaatgcacct caacatcctg gaacactcag gacaatcccc agcaacaaaa 82801 acctacccat ccagaacatc aacagggctg tggctgagga gccctgctct agtgcttcct 82861 ccttactgta tcctcatcaa ggagggctct ggggcatgtc aggggctgct acaggctcct 82921 ggcagatttc ggcgacttac tccagacttg tggaacattc aggattctta gcatggccac 82981 aggagagtca ggctgtccac aagcactctc tctttcttca cccactcatt cctgtcactc 83041 taccatttcc actgccttcc caaatgccca tcgtgagtcc caccaggggc cagaacacca 83101 ctctctcaag cctccccagt ggcgcgtgca cacctggaga acatgtctca catcccccag 83161 ccagcgagac gtcctgagat tccagcactt ctcagtgtct ttcccagctt gtttgtatct 83221 ggaatggggt ggggtctctc acacaggaga aattacaagg aaaagtgtac gtgacaggaa 83281 tggaggaatt tctgtggaaa cggtgtgtga gaaaatgtag gaagaaagaa acttcaggaa EPI-109 1125

83341 atggtaagtg gcatcttgag agcagaaagt gagaagggag cagaaagaaa tggggctgga

83401 acctgggaag gagaggacag gtggggatgg ccttgcacac cgtgggcact gaggagtgtg

83461 ggcccatggc atgggtggag aggagtttca agatagggag tagattccta ttttgaactt

83521 cggattgccc ctggcgatgt ggagactgta ttggaagaag gcaagaatgg aggagagccc

83581 ctaggtggag gtttggcaat gctctctcca gaatatagca gaggcctctt ccaaggtagg

83641 aaagccctga ctggagagaa gttaatggct ctgagggctc aagggaggac ttggattatc

83701 aggactttta gggaggcata tgatcaaggc ttgggtcttg gcccattgaa atggggagca

83761 ctggttttag gatgtgggtc aattagtttg gttttcagga caggctgagt tggatatcct

83821 gggggacctc caggtggcag tgtcagggga agctggatgt gctgacactg aactcagcag

83881 agtgactgag tagagatcga catctggggt cacaggcagt ggatgccgta ggggtggact

83g41 caatagctca agcagaaccc ggaggaatgc aggcagcaaa gggagcccta aagaacagtg

84001 aggagatgtg ccaagaaaga gccaaatccg ggggattggc tgtgggagag agggctgtgg

84061 gagtaagagg aagtgtcagc aacgtcaaat gttgcagaga catagagtaa ggtaagagtg

84121 gaaaaaacat ccatggaacc ctgtgatgca atcggaatgc agaaagactt tgtaactcct

84181 gcctggtctc ctcctctgcc cactcatggc aaaggaatac aaagtaatgt tccctccttc

84241 cgcctagaaa agcacaactt ctgcccccaa gccctgggct ctcctgagag gacaggacca

84301 gcctctgaag ttgaaggtcc tggttctgcc cccaagccct gggctctcct gagaggacag

84361 gaccagcctc tgaagttgaa ggtcctggtt taccagatag ggaaggggcc ctttccaaga

84421 ccctttccag aaggtgtggc tgagatggga accgtggact ctgtgcagat gtaggagctg

84481 gctccagtca agtgctagga ggttgtgggt cctgggaagg aagaggctct ggagcctctg

84541 tggagactct gggactgtcc ttgggggaga cgtgagcagg aagaagcagg gccttcacag

84601 tccccagctt aggggcctca ccacccagac tgaagaccag gaccaaaccc tttcctgcac

84661 agttacaatg tgtcatttaa ttttactaaa gggaatattt tttaaatgag gatgctactt

84721 tgtgtattaa tttttacctc tattcataaa agaaacgttt cttatctatt taagatgatt

84781 catatcagac cagtgtctgc ccaactcgac tgaccctgtg aaaactgggc acttcacact

84841 ccaatgatga tggatgagtc cccagcagca tagtttaagg gagtgagtgg gcagtgtggc

84901 ctcctgtgca cgtgacttcc tccttcagtg tgcccacatg tgggttccac ggtcttgtga

84961 cattgtggct ttagaaattt ctgtttccat tttctatcat tcagagtaaa tgaaatttgc

85021 aggaaattca gaaccttcca cctgtacagt ggatactgtg agactctgcc cagatgccct

85081 cttcaagcca atgcatctct ccatgctccc actcccatag atgggaacag aggtgctgga

85141 actcagatct actccccttt ctgggaactg gagctgcctg cccaggcaat gcccccttcc

85201 cagggatggc tgagccaatg actggctaat gttggattgc agaggcctag cgccctcccc

85261 tcaattccta attccttgta ggaataactg aggcctcctc tgtgaccacg tgggcagctt

85321 ctccctctgc ctggtcctgt cttgttctct cctttccaat tgtgtctcct ggaagccctc

85381 cccacaagtc tgctgcatac aactctcctt ctcagagagc ctgagccctg gattcccagg

85441 aatccagcct aaaatagtct ggcatttggt ttcaattttc tctttcacta agactcagtc

85501 acaggtgcta ataaataata aaatgtcacc accttgaatt ctatcactct ctcttttctt

85561 gccccatctc tgacaagtag gtggtccctc aagaacctga aaagcagaca ttaggaggaa

85621 aggaggagtg ggggcaagag gcccacacct cacctggccg gctcccatcc atgcgccctt

85681 gactgaggta acacctaccc tgggaatcct tcccctgcct ctcgtgagcc aggccgggtg

85741 ctcttgggac agctcccact gctcctgtgt gctcccccag cttggcacat gactccctga

85801 attatagtca gttccgtacc tgaatctccc tctagaatgc cagtgccacg aggacagagg

85861 acggttccac tttgttcact attttctccc cagggtctgg caaagttcct gggacttggg

85921 agaggtgtcc ttcaggagct tggcagaagc caaacggcac acttaagtag ggcaactgag

85981 gtgagtttaa tgaaggattc tatacaaaaa tttggacaag gtatagggag gccacaatac

86041 acagtgcagt gcctggtgcc agtgagagca gggcactatt cccactgcaa ggccagacag

86101 ggcaagggga gggagctgcc tgacaagagc tgcccttacg tcaagggaca catcagccca

86161 ctagacccca tcaggaggga gccagggcct gactcccctg accttgctct ccaatcttct

86221 gcctaaaatt ccccatcagc caaacacaac tgaaaactga aagacagggg agcctgctgt

86281 taataaggtg agcttccccc agaataaagc tgggtagaga gtggagaatg gatatggaag

86341 ggcaaaagga agatttataa gacagtgggc actaaatatc tatgagatga ataaaggaac

86401 cacattttac aacaaacggt cattgaaacg ctactcaatg gaaagagatc atttcggtca

86461 ctgtctggtg cagacaaatc aaagcccaca tgcatcaaaa aggccatgtc cgtgtaactc

86521 cgacacgggg cagacagcaa ggctgaagcc tatggggtat gtggagccgg aactgagaga

86581 tcctgatgta aatctagcac ttgggaaaag ggggactaga agaaattcac ccacaggcag

86641 aggaaaacac aaacacttat ctatttttgc ctaggcttta agtggtatgg gaaaaatctc

86701 tgagactaca aatcctgtgc ttcatgcaca ggtttataat accctcaaaa tggaagaccc

86761 caaaaccagg cgcggaaaat tcatatcagg ccattgatgc cctcaatgtt cccggctgaa

86821 acaaactcaa aactcctctg gaaaggagtg ctcccacttc aagccatgaa aagctactgc

86881 agagaaaata atccccagtc aagacacact cacattgaaa ctgcaaggca cacaaggaaa

86941 tggatcacct tgagtgatag ctggcagagc taataaacct ctgtatacct ctaagaagct

87001 ccacgcacta gtataaccct taaagatttg atgaaatcat tactttatta aaattgtttt

87061 tataaaaaat caaaatccaa aaaaagcaac aaattttata ccagagccaa ttcggtatat

87121 acaagggtgt cttactcttt tggaatttgt cttattgtcc taactcagca cattgtcctg

87181 gtctatgaaa agtcctagaa acccttctac cctctgtaat gtaggagctt taactcaata

87241 gggtttttta aattcttttt tcttgtcttt ttttcttttt taattttttc cattttttca

87301 agtcaaactg aagaaatatt tttcttttct ttctaggaat gcatattcac cccccaaggc

87361 cacttgtctc ctgattggag agtattagac aattctcagg atttctttat tttccttctt

87421 tattccatag gattgggaaa cccagtagga ttgggtttag gcatatctct aaagcaccat

87481 gtttcaacgt tttgatgtaa gattgtgccc tatttcttgt tcagttgctg ccagcagatg

87541 ttatagtttt aaaactagtt tttggtcatt gagatattag aggagggaag agtctgctat

87601 cctgctttac tcatcttcat ctacactaca ctgtcatctt cactgcaaag tcctgtatta

87661 atgtttttag attctataac attttaacag gtgtcaaaaa atcttaagca ccacttcagc

87721 ttgggaatct ctaaatgtaa tggtgtttgt gggctggact gatgtctgcg tcttgttgtt

87781 gttattgtct gtagtaatgg agagccggga gatcctggac acttcctgtt catgggcact EPI-109 1 126

87841 tgatgcatta gctgccccag cagctgatta catttaaaca aggatgtgtg ggtgaaccca 87901 gggagaccaa tctcagtgga atggtggggg cagaagccag gctgcagggt gtagagtagg 87961 gaatgagcag tgatgaagta gaaacagagt ttggacaact agtgaaactg cctggaagag 88021 ggggagaaga gacagtaaat ggtctgacca atgtttgagg tcaaagtggg tttgtaatct 88081 ttatttaagg gacagatctg agcatttaaa aattctgaat aatctaatag agaggaaaaa 88141 gttgggactc aaagaaaatg tgggaaaaaa tgatgaaggt taaacggaat gagatccaga 88201 gtgcaggggg agagattagc ctttggtgtt agaggagcaa ctctgtccat ggagagagga 88261 aaaatgtaga cataccacag ttgcatttga agttggggcc tgaggagttg aggagttctg 88321 agaaaagcag aagatgagat catttcctga gagtaaatgg gagtcattag aacgggggtg 88381 aagagactgg aagctttagg tagcttgaaa tagttgatgg aaaaattgga taaagtgaca 88441 atttgtcaca ctcagaacag ctatcaggga atctagaaga atctctggaa gctagttgaa 88501 gatcttaaat taccaatgta tcttgtccac atagctaagc ggttttactt atttttattt 88561 ttttgaaaca gggtctcact ctgtcacaca ggctggagtg tagtagtagt agcacaatca 88621 cagctcaatg caatctctgc ctcccgggct caagcaatcc tcccacccca gcctcccggg 88681 cctgggacta cagacacaca ccaccactcc cagctatatt ttgtacattt gtagagacag 88741 ggtctcgcca tgttgcccaa gctggtcttg aactcctggg ctcaagtaat ctgcccacct 88801 cggcctccca aagtgctggg attacaagct tgagcccggc tgctaagtgg ttttaaacag 88861 ctgttctcgg aaacacacac tcaaagaaaa aatgtagagg ataatttatc taaggctggg 88921 gcttcaagag aggtcagggt gttgacaaga gaatgactaa gtggcagact actggatctc 88981 agctagataa agagggatgt gatcgtggga ggggctgata gtcagaggct ggaaggcttg 89041 atgaacaaca catattacac aaagaataaa tggagtgaga gaaaccaaag gagtaaaagt 89101 tgtcatcaga aaagtgagaa attttattgt gagaattcag tggtaaatca atgttaacaa 89161 acctcagctg ggcactagtg gagtgaaacc gaaggccagg gagttgagtt aatgagctga 89221 gacttgggca ccagatgggg gtccacatgg acaactaagc caccaggatg atgtgggaaa 89281 ctggggtgaa tagaagcccc ttatccatgt gcacaagtct tgaataaaat aggggcaacc 89341 aggcagtcag tggatgatag cagtgaggtg gagcagagag caatgtagtt ggagaagtgg 89401 agcccacagc agtctccttt atatctagaa gggaattaat agccaaaaaa tggcaccgag 89461 gccaaggatg tcaccttctg actcccaaat ctgagacaga tgtgagaggg aaggagtatc 89521 ctcaagggac aggagatggt gcgaatgttt ttggcataaa tcaaagatgt cagggaaatt 89581 gtcagaattc aggttccaga gacacagagg aaaagcgtgg gagaaagtgg aatattggga 89641 ggtgagatta gggcagagga agcacaaatc aaagaacgag gaatagaaaa agtcatatga 89701 gctgaggagt tggccaaaca tgacagaatg ggaatatgat ggaattaagt ggctttatgt 89761 gttccaaaag gattggtcca cgcaggccac aggaaaatgg gaggtaagaa gaaagggatc 89821 gaaatgctgc aaagtgtatt acttcatggt aagcaaagga ctcaagactc tagaaaatga 89881 tgcccttcct tccaagacta tgttagtcca aatctttcaa gatacagaac ccaaggtggg 89941 gtctggcata caagaagtat aatagaggaa atgtctgtga catttgcagg actgcaaagg 90001 gagccaggag aagctgggaa agccatgaga tcacaagcag gtctgactcc aagtgaagga 90061 gatggggaat gacgcaaggt ttggctgaag catgtgccaa aggcacccat cagaggagtc 90121 cctctccaag ggatgggcct atcatagtgt ccctaatagt gtcatggagt gggagcagcc 90181 cacggagggc acagccttgg catgaacgca gacatgggtc tcagagtgca gcagctgggc 90241 ccctcagtca attaggctcc ctcagagctg gggcaggagg tgcactagac cacacagtaa 90301 tatttattta ttattaattt aattaataat attaatttat taatttaatt aataatatat 90361 ttatttattt attattacta gaccacacag tagtatttgt atgtctaagg aagcatttct 90421 cagaatatac tcactgaact tttagcctat aagtacctgt atgaaaattt taaaaggggt 90481 ttcatgatca aaacattttg ggaaacactc catacccttt cttcctcatg aaggatcata 90541 atgcctatta gtatatgaag ggctctgaga agtcctgtag taaagaaact tgctttagtt 90601 ttttagtcca gcaatttttc aaacttaaat gagcaatagc ctcccatcct tttttttaca 90661 ctttttagca tactgcggaa taaactcaac atgcattgag aaagactgct ttagggaata 90721 gtcaacacta tttcactccc agtaagtaca tataaaatct gtatttccag ggtggattat 90781 caacacagct gtattttaga aatattatct gccctcccag gtatcacagc tactaattat 90841 tgggtactga ggtggaattt tagggatcag ccaattatgg gaaagaaaat ctgggggcag 90901 gataagatgg tctccgaagc cttaaaatta tatgccatta tttacctctt tgatctacta 90961 ctcaatatca aacaactaat tcagaagaaa attgattgtt ttctaaaagt agtttttcta 91021 catttcccat taagaagcag tggtatttaa aacttataat ggctattatg tgagattatc 91081 actatcatag tttttctcta tacaaatttt ctgtaacatt ttatttgcta ataaaaatta 91141 gatagatgga ttgactaatt gataatctaa gaaagattat atttgaagaa gccatagtaa 91201 gggacagatt aaattatcat cagtctaaac attctaatac ctatttctct ttttttgaaa 91261 ttttccaaat ttgttattat gcatttaaac aataattttt tgaactttta ttttaggttc 91321 tggggtacat gtgaaagctt gttacatagg taaccttttg tcatgagggt ttgttgtaca 91381 aattatttca tcactcagct atcaagccca gtactcaata ggtatctttt ctgctcctct 91441 ccctcctccc accctccagt ctcaagtaga cctcggtgtc tgttgttccc ttctttgagt 91501 tcatgtgttc tcatcattta gctcccactt ataagtgaga atacaaggta tttggttttc 91561 tgttcctgtg ttagtttgct aagggtaata gcctccagct ccattcgtgt ttccacaaaa 91621 aaacatgatc tcgttctttt catggctgca tagtattcca tggtgtatat gtaccacact 91681 ttctttatct aatctgtcat tgatgggcat ttaggtttat tccatgtctt tgctactgtg 91741 aatagtgctg caatgaacat tcacatgcgt gtgtcttcat ggtagaatga tttatattcc 91801 tctgggtgta tacccagtaa tgggatttct gtttttagct ctttgatcta atacctattt 91861 ctcaagatca agttagatct ctaaaaaagg catcatccta gcatttcccc atcccttccc 91921 tgaactaaat ttaatgttgt gtgtatcaat cagcatacag tcaagacaga aaccacacat 91981 gaacattaaa tataatgagt tattaactta taaaagggta tgaactacta aagggggtaa 92041 ggagaatgct gaagaatgca ggaatggcag atgtagagag cagccataac ctctaagcta 92101 aggcacagca gccaaggaag gggcgaactc aaaaaatgcc ctccctcccc agctgatcca 92161 cccttgttgg agggggtgtg gctgcaaccc aatggatgcc caagaagttt gcagagttgt 92221 ggcaggttgg ggctgctgag caggaaactg cccgaagggg taccagtgag attcccaaga 92281 atgtgggcat gcctctggcg aggaagacgc tcttggagtg ccagcaaaat ttactaggaa EPI-109 1 127

92341 gctacccagt agggtgccag caaaagtcag caggaagcca ctgtcgtggt gtcggcaaaa 92401 ttcactgagg agtgggcact gcagggtctc cacccagcac tggcaaatca gccaaaagaa 92461 caaaaacaaa ataaaaacaa atcccagaac cagaaagaaa aaactctgcc tcttactgcg 92521 accctcttat gccttctaca gcaactggca aaggagaaat gtttatgggg tccagctcta 92581 gactcacaaa gcagaacaca gaagagtgaa tgaagagctg aaaggcgata aatcagtaac 92641 tggagcctca catcctttgc cttttttatt gagggtcaat atattaagaa gaatatgtct 92701 gcgtcttcgg taaaattatt gctaaggtta tcacccagtg tgtgttttca acctccctga 92761 tataagaact tagtgacaag aaagaatgag acaatgatca tgaactattg gacccaacca 92821 tttgtggctt tagtgcccat cttctcagca aggctttctc tctctctctc tctctctctc 92881 tctctctctc tttttttttt tttttttttt ttttaagatg gagtctcact ctgtcaccca 92941 ggccggagtg cagtggcaca atcttggctc acggcaacct ccacctcctg ggttcgagtg 93001 attctcctgc ttcagcctcc cgagtagctg ggattacggg cacccatcgc cacccctcct 93061 ggctaatttt tgtattttta gtagagatga agttttgcca tgtcggccag gctgttctca 93121 aactcctgac ctcaagtgat ccacccacct cagcctccca aagtgctggg attacaggca 93181 tgagccacca cagccagctc tcagcaaggc tttttctgac tacactattt aaaatgtgat 93241 ccctgagcca ccttggcctc tcttgctgtc cttccctgct tcgccttctc catagcactt 93301 ctctcctact aatctacaat ttacttgagc tctgtgaagg tcaggatttt tgcctatttt 93361 gtccattggt gcatccccag cacctggaac agagctaggc acaggctagg cactctagaa 93421 atacttgctg aataattgaa ttaagtaaat gagtgatcta cacgtagtgg ggaatgagag 93481 tatacagtga tagttccttc gactaaaact ggggtcaaat tatagtgata aagaggaact 93541 cagaccttca gaggtaagct ttgtggacca cttgccaagg ctgcagaatg tgatgtcgtt 93601 tcacaaacaa ggaggcccta ttatggcttc agatatgaga ataataaaga gaactttcct 93661 ttcgcctcaa ctgcagcctt ctaaactctt ccttccttcc tatgtagaag tttcaaggac 93721 ctcatggcct gagtgtggat aggcagaatg ctgggaatca ggcaaaaata aaataatact 93781 gaaagtgaag gtcatgctaa tattagtaag ccagggtgat cctgaattta caaaacattt 93841 ttctttggga aatttcacac ctcacatgat tctgtgtttt tacttgggaa atttcacatc 93901 tcacatgact ctgtgacatg cggtacatga ggtgcctgac tgctgttttt gtcctctact 93961 aatgaggaag agtgtgcgta ctcccagcgt tttgcaagtt tcaaagtctg acttgacttt 94021 ccttcctttt cctggaactg atccatgagt atcgagagta aagctgcccg cacctactca 94081 ttcaagatcc tgagtgtcct gcccagctgc aggaggtgga gagacacagg aggaggggcc 94141 actgctgatc ccaggctgta gggggtggga agagtgtccc agggcaccat gacccccact 94201 cactcactca caggagaccc acacaagaga ggagagggca cttacagctt aggttcccac 94261 cagcaccaac tcctctgcca tcaaacatca ttgtgtttct ctttctgcct tgtctgtcgg 94321 cacacgtgga gttaaattta atgctcaatc acatatttgt ctgggctctt tctgtgttta 94381 tttttctctt aatagttctc tctcctccct tcctctcccc gcccctcctc ctccttcttc 94441 tttttttttt ccagagacag tgtctcgctc tgccacccag gccagagtgc agagtggcat 94501 gatcatggct caccgcagcc tccaactcct gggctcacgt gaacatccca ccttggcctc 94561 tggaatgtct gggattacag gcacttgcca ctgcatctgg ctaattttta tattgtttat 94621 agatccggga tctcactatg ttgcccaggc tggcctcaaa ctcctgggct caagcgaccc 94681 tcccacctca tacttctgag tagctggggc tgtaggaatg cgcctcagtg ccaggctagt 94741 ttcttaattt tctatttcta ttttgacagg tacaaatttt gtattcaatc ctacctcaga 94801 cacatctttg gtgggaaaag gatgtcattt aatcaatata taaattctaa gcaaataggt 94861 ctgatcccca aattaggtta gtcacagctg ctgagtcgtt gacccaagag aagctcatct 94921 agattttttc attattttca agttcctctt ctcggttcgt ccttcttcca gaccatgccc 94981 tccccgtccc actctcttcc cacagcctcc cctccccaca gcctcctccc accattccaa 95041 atctgggctg ttctctcaat ttccttctct ctggactcaa acctacccta gcccccagcc 95101 tcagtttggg gttaaacttg tcctcctcac attctctccc acccaacttg atgtcgcctc 95161 tgtgtcatca ccacgggatt ttcctcctct gggttctcct tttccgagtg gggtcagctc 95221 ccccatgagt cacagcacca atcacttctg gctgcttgca aacccctttg ctttcctcag 95281 tgttgacacc cagggcagcc ctatgctcac tgccgctgag accccacctc tgcccctggc 95341 cttttcccag ctgacatcac cctgtggctt ccattttcct aaaattctct tttgaggcct 95401 cagtcttaac caaagcacac agtgcccctc aaaaatgaca ataaaaaccc aaacacaccg 95461 tgactgtcat ggcaggttcc tggtccccgt attgaatcag cgggtgggtt tctgcgaaca 95521 ctggtgagag gccgcattag agggtcagga ccctcaggtc tggactcgtg gtcaccacat 95581 accttcctcc ctgctgacag tagctggtac ctgttaccta ctcagagtgt cacatgccac 95641 aagccagagc gtcttggcag ttctcagcac cttgacatca cttccttgct accactcaga 95701 gcggcagtga cacagttccc ttatctcaga aggccagaag acggctgtca aaggtcacag 95761 ggaaatcaaa ggcggggtac agggccagag ggaggaggaa acaacttccc ggttgctttc 95821 agacgcttca gagatcctct ggaggcctgg gggagctttt gagtacttta tttcagttgg 95881 tccctgagct cggtgagtgg ggcgggtaga gccaccaggg gaatcaacag tggtttctcg 95941 tgcccctcag ggtcaggagc agtctgatca aaaggagggc atccactgtc cggggccatt 96001 cccacagctc ccggatgctg ggtctggagg ctgcgccctt cccctgcagg agctcagccc 96061 agtggtaagt catctgtgtg tcatctatgt atttaacccc ttatggccat gttgatgctg 96121 agcatggttt cacttttgca aacatttatt tatacccttc gagagaaaaa cgtctcagct 96181 gtcacaggaa gctgcttcgg ggggtgagca aactttttaa aatgcagaaa ttatgatcta 96241 cacccgtttc ttaaaagtaa gccatcgtac ttggttctct ttaattatat attttcttac 96301 atattgtgtt catgtaggca agtcctgttt ctgctaaaag aaggtaagtt ctaccaaggc 96361 ggtgtcatgc cagctttatt tcccgtggca cctggcacac tgctaagcac ttacatgctt 96421 aacaactaga ttgggaatgg tgctgctctg gggaagtggg cacacgttaa agaaatgttt 96481 atttcagtct tctgaaatag ggaattactc tggctaaaat gtagctccag aaagggaaag 96541 tggggctgta tgaatccagg tccagtttgt tgtttcctcc aggataaggc agctgtcgga 96601 ggggaaaatc atctcccatt tctccacagg gcagtctgaa gatggccaat tacacgctgg 96661 caccagagga tgaatatgat gtcctcatag aaggtgaact ggagagcgat gaggcagagc 96721 aatgtgacaa gtatgacgcc caggcactct cagcccagct ggtgccatca ctctgctctg 96781 ctgtgtttgt gatcggtgtc ctggacaatc tcctggttgt gcttatcctg gtaaaatata EPI-109 1128

96841 aaggactcaa acgcgtggaa aatatctatc ttctaaactt ggcagtttct aacttgtgtt

96901 tcttgcttac cctgcccttc tgggctcatg ctgggggcga tcccatgtgt aaaattctca

96961 ttggactgta cttcgtgggc ctgtacagtg agacattttt caattgcctt ctgactgtgc

97021 aaaggtacct agtgtttttg cacaagggca actttttctc agccaggagg agggtgccct

97081 gtggcatcat tacaagtgtc ctggcatggg taacagccat tctggccact ttgcctgaat

97141 acgtggttta taaacctcag atggaagacc agaaatacaa gtgtgcattt agcagaactc

97201 ccttcctgcc agctgatgag acattctgga agcattttct gactttaaaa atgaacattt

97261 cggttcttgt cctcccccta tttattttta catttctcta tgtgcaaatg agaaaaacac

97321 taaggttcag ggagcagagg tatagccttt tcaagcttgt ttttgccata atggtagtct

97381 tccttctgat gtgggcgccc tacaatattg catttttcct gtccactttc aaagaacact

97441 tctccctgag tgactgcaag agcagctaca atctggacaa aagtgttcac atcactaaac

97501 tcatcgccac cacccactgc tgcatcaacc ctctcctgta tgcgtttctt gatgggacat

97561 ttagcaaata cctctgccgc tgtttccatc tgcgtagtaa caccccactt caacccaggg

97621 ggcagtctgc acaaggcaca tcgagggaag aacctgacca ttccaccgaa gtgtaaacta

97681 gcatccacca aatgcaagaa gaataaacat ggattttcat ctttctgcat tatttcatgt

97741 aaattttcta cacatttgta tacaaaatcg gatacaggaa gaaaagggag aggtgagcta

97801 acatttgcta agcactgaat ttgtctcagg caccgtgcaa ggctctttac aaacgtgagc

97861 tccttcgcct cctaccactt gtccatagtg tggataggac tagtctcatt tctctgagaa

97921 gaaaactaag gcgcggaaat ttgtctaaga tcacataact aggaagtggc agaactgatt

97981 ctccagccct ggtagcattt gctcagagcc tacgcttggt ccagaacatc aaactccaaa

98041 ccctggggac aaacgacatg aaataaatgt attttaaaac atctatttaa tgtattttaa

98101 aataatttgt aagttgattt taaaaccaat ttaactacat tccaaattat agacagccca

98161 tttatatggg agtaactttt caggctcatt gcctcgccgg tgatgagaag aactagctag

98221 ctggaagctg tgggaaaaag aggtaaggta acttgttctg tcgaagttct ctaaattctc

98281 ttgcttactt gccacacccc taggccccca gcttccccta acccaaggtt tctggtattt

98341 tctcgtactt tatcaagact atggaatctt aggagactta acaaaagcaa atgagaaatt

98401 atgtttagaa atgtctaaca aaatgaattc tttgtccttt taagtataac acatacctca

98461 ggcctcacca gcacataact acaaaaggtt gtcccacttc ctttctgtgg ctgagttagt

98521 agaacacagg ctcccacctg ccacatcagc agaaggtcac ctcaacatgt gagctacctc

98581 cccggagacc ccccagatcc gtaaggatga tgcatccttg atcctaaaaa cattttcctg

98641 ttcctggtgt tcagaattgg actccacact cactggtctc tttataatct tgcttctggc

98701 cctttgaggc ctcaaagcta ccagggcctt gctgccaggg gacaatcacc gctcccggct

98761 gagtcctgca gacatagggc ctgggctggc tgcctcctcc tgctggccca gcatcttgct

98821 tgcactaaag agagctggag gcttggcact gatgcttgct aaaaacctac ccaggccgcc

98881 cactgctgcc gcactgcagg gcaccagccc acactcctcc cctcctggca tcaggcacac

98941 gttcacggca ctaaacctta caggaaagca gtggaaccct gtctttcctt cacaggaggc

99001 actttccttc ctaggcaaaa acgatgatac ccatgggcac agcatctcac atagggacac

99061 atagagatgt ctgactcatt aaaacccaag tctctggcca attaaaaggg gtccttaatg

99121 tcctactcaa cagtggtgga aggaaatttg ctctatattg atgaaatgag gtggagaaaa

99181 tctgattttc caaacatgag aattctccat atgccacccc ataaccaaag accccttatt

99241 tgtgttagat gaaacattca aagagcctat taggatagcg gatgagaccc ccaagggaca

99301 tgcttataca acaataactg gctccaaacc acactccatg gcagtggctc tcaaatgcca

99361 gctcacatca caagccctgt gctaaaacac agagttctgg gccccatccc ggagtttgtg

99421 gttcaggagg tctggagtgt gacctcagaa tatgcatttc taacaaattc cccaggggat

99481 gcagatactg ctgacccaag gccctccttc tgagaaccac tgttccaggg agaagaaact

99541 cagctaagta agggtttggc tttgtgctga agacaatgtg gaatttagag ttggggtgaa

99601 ttattcagga aagtagagag gtttggagat gtgagggtgg gaagcgcagt ggagggaggc

99661 agagaggaaa tatgaagcag cgtcagttgg agagaaatta ggaagaggaa taaaatgata

99721 tatgccaggg atttcagttt tgctgagccc atgatgacag actcttctct ggcaccttat

99781 gccactcatt gagggcttgt agctggctct gctctttcag agtcataata gggctatggg

9g841 tctgacctca aggtgagctg gaatgggcac aagtaataga taaaactgca agaagtcact

99901 caagggtcct tcctagaaca aaggatccct acattccaaa ggcgaatgcc ggtcactatc

99961 ataaaagaaa agaaagaaag aaactgatgg tgacatttta aatggcaatt tttctagctt

100021 ctaaaaggtt gtggagcaac tggaactttc ataccctgct ggtgggaatg taaaatggta

100081 taatcacttt ggaaaaattg gcagtgtcac caaaagcaaa gcctatacct actatccatt

100141 tcactcctca gtatttaccc aagagaaatg agcatgtatg tccatacaaa gatttggacc

100201 caaatgttca tgacagcctt atttatatag cctcaaacta gaaaaagtct gtctatcaac

100261 aggtgaatgg ataaacaaat actggcctgt gtatctaatg gaatactgct catccacaaa

100321 aagaaacgag ctattgatac acacaggagc atgcacgaaa tctcaaaatg ctgaatgaag

100381 gaggccagat tttaatttta tttttaatta tttatttatt tatttatttt tgagacagag

100441 tctcgctctg tcacccagcc tggaatgcaa tggtgtgatc ttggctgact gcaacctctg

100501 cctcctgagt tcaagcaatt ctcatgcctc agcctcccaa gtagctgtga ctacagtcat

100561 gcacaagagc aactgactaa tttttgtaat tttagtagag acggggtttt gccatgttgg

100621 ccagctgctc tcacactcct gacctcaggt gatccacctg cctcggcctc ctaaagtgct

100681 gggattacag gcatgagtca ccgtgcccag ccggaagcca gatatttttt aaaagtactt

100741 attttgtgat tctatttata taaaattcta gaaaatgcaa acaaatccat agcgacagca

100801 aatcagtggt tgctggagat gttggagggg agaggagagg aatagattgc aaaggggaac

100861 aaggaaattc ggggggacag tggatatgtc tgctattttg actgtggtga tggtttcatt

100921 ggtatataca tatgtcaaaa acgtaacaag ttgtatacgt gatttattat gtgttgacta

100981 tacctcaaaa aggctatttt ttaaaatccc cctcaggctc caggcactcc attacgttgg

101041 tgtgacttgt cttggaaata tactttgagc atttgccgga ggagatccag tgcctgggcc

101101 tctgtttctt ctcccaagta gaattggcag ctaaaacggg atgcccatgg gcacaacttg

101161 tcacccccat caccgaacag ggagcagaag gaggctgctg ggggtgcccc cacagggagc

101221 acagtctcat cgggaatgac ctgccatggc aaataaaatc accagggcaa gtcaagggag

101281 agaccaggga agagagtgat ccagtctata ttaaaaaagg atgagaaagg ttgaagaaaa EPI-109 1129

101341 agagaagaag ggacagaaat tctcttcaca catttgcaga agtaggtccg gactctccat

101401 ccacttctcc tcctccgata ggtaggacag gaatctcaga ggaaatggca tcatcttccc

101461 atgtttacag acacagcaat gaactcaaag aacaatctta tcaggatttt ccaaatgaaa

101521 acatggagca tatagagaat aaagatccat aaactcgtat ggtggctgag actgaaatgg

101581 ttaatgaaaa gcaaaagtgt gtgctgaatg acaccagcca caatggcctg aacacttaag

101641 tagtgtaata tacttggaac attgacagct aacaaggtct tcctcccatg tcagaccaag

101701 aacacagttt cctaaagata aaaatagcac atgcttttcc acttttccat aagtgactgc

101761 attagaaaac taacaaacca tgaaaagcaa aatatggcta gtctcttcaa gaaaaactgg

101821 tgtttctatt ttgtctgtaa attactttct aatacaaaaa acaattcctg ttacattgag

101881 gtaattctaa ctagggacat atgagagaga gattgaaatc tcatgagctg tctccttttc

101941 atctcaattc tgtgtactcg tgggtacaaa tggaactagt ttttgtttgt ttgtttgttt

102001 tttgagatgg agtcttgcgc tgttgcccag gctggagtgc aaaggtgtga tctcggctca

102061 ctgcaacctc tgcctcctgg gttcaagcaa ttctcctgcc tcagcctcct gaatagctga

102121 gattacaggc gcctgccacc atgcctgact aatttttttt ttgtttgtat tttttagtag

102181 agacagggtt tcaccatgtt ggtcaggctg gtctcaaact cctgacctca ggtgatccac

102241 ccacctcggc ctcccaaagt gctgggatta caggcgtgag ccactgcacc tggcccggaa

102301 ctagttttaa aacaggaaac agttgatata ctgaatggaa aaacaataca atttgaagtt

102361 gaaaaaacaa aataagatgc ccagttaaat ttaaatttca gttaagcagc taatagttat

102421 ttagtataag tacaacccat atacgacaat tgcagtattt gttatttatc tgaaattcag

102481 acttacctgg gcatcctagt atcctgtttt ttgttttgtt ttgtttttcc ctttgttttc

102541 ttttttttcc ccgaaatctg accaccttaa ctttaaggta tttattcatt tttaaaaact

102601 aaatattttt cggcagtcag aactagagca aagataaatg atcccaggac tctgtttagc

102661 aggcagtcag gaagtgtgac agtgtggtgg gtggcagccc cggccaggcc tttcctcttc

102721 cctaaactgc cacagcagga ctgccacact tgggaatccc agtttccatc tgagcagccc

102781 ctccagagtt tggaaggagt cagtgcttta gcctgaggag ccgtggatgg ctctaacact

102841 ttgcttgtcg gttgaataaa aatcaaccca aaggtggcct acactcattg aagtaggaat

102901 gccagaactt cagtggtgtc acatagaaga aaatatctaa gtgcttaggg agatggcagt

102961 gctagtggat ctactggatc attaagactc actcacccac ccagcgcagg tctagaggac

103021 acacccttgc cacactggga agtgtaaatg agctccagca tctttatttt tttttatttt

103081 ttatttgttt tattatactt taagttttag ggtacacgtg cacaaagtgc aggtttgtta

103141 catatgtata catgtgccat gttggtgtgc tgcacccatt aactcgtcat ttaacattag

103201 gtatatctcc taatgctatc cctccccccg cccccggtgt gtgatgtccc ccttcctgtg

103261 tccatgtgtt cttattgttc aattcccacc tatgagtgag aacatggggt gtttggtttt

103321 ttgtccttgt gatagtttgc tgagaatgat ggtttccagc ttcatccatg tcccgcatct

103381 ttaaaaaaaa aaaaaaatct ctaagtggtg gctcttctct gtagatcagg agctgtagtg

103441 agcaatgcta caaaactgga gtttctaaat acagggggga tggtgggatt ctgaggaagg

103501 acaggccacg tggtaacact tacaaaagac caagtgggtg tggttgccac tgtggacggt

103561 ggagccaaag cagtcctcag aatagtctga cccccagagg tctttggcat tggctggttg

103621 atcatggtgt ccctggaatt gaaatagaag gacggtctac taaattttta cctgatctgt

103681 ataagcagaa gagttctatc tctagtgaac agaagtctaa ctttagtcac cagaactgag

103741 agtcaattca atcaattccc agatttgaca tagtttatag acctagaacc ccttgaatga

103801 aaggtaagct ggctcccctt gaggaaggac cctgttacat ttccggcatt ttattctgat

103861 aatctttttt cccagccttc cccaaagcaa cttagggcca tttaccaggg aaagccatgg

103921 aggaaaagga aataattagg ctatttggag attccaggac actggctcta cgctgacacc

103981 agttctaaga gacccaaaat atctttgtgg tctaccagcc aaagtagggc ttcatagagg

104041 tcaggggtca ctagagtttg agctcaggtc tgtttcactg tgagtctaga gggtccctga

104101 acttatccta tagttattcc cccagttcca gaatgcagaa ttgagctgag agcagtggct

104161 catgcttgta gtcccaacac tctgggaggc gaaggtgaga ggatcacttg agccaagcgg

104221 tttgagacca gcctgggaaa tatagtgaga ccccatcttt taaaaagaca aagaaaaata

104281 aagaaaattg acatggaaaa ataatataaa atgtgaataa tctcacatct actaaagaaa

104341 ttcaatctgt aattagaact cctcccacag agaactataa gcccagtgcc cccatcaact

104401 ggagaaacag aaagaaacaa tcttcttaac agaaagcata attggaatag agatactctg

104461 catcggggaa gaatccccat attgattctc tgatccatag agtgaaggcc aagtggaagc

104521 ctttggaact ccctctacct gccaagatac taaacaaaac aacactgcac gtctggagga

104581 attgtagcaa gaacttgaaa gatgaaggat gatgatgtcc acctctctcc attcagctca

104641 cctatctggt ttgtgcagaa gacaaatagg tgttggaaaa tgacagtgga ccagtgtaaa

104701 cttaatcagg cgggggctcc agctgcagct gcaggatcag gtgttgtttc atttctgcag

104761 ctaatcaacc cttctcctgg cacctggtgt gcagatggca atttttcttt tctattatct

104821 gttagtaaag actatcagaa gctgtttatt ttcagttggc aaggtcagca atacactcca

104881 agggaagagc agtctgtctc agatcttacc gatgcctggg gatagggagg gagtggcccc

104941 ctcaccgtct ccaaggccta gtcctctgct cctgctactg gcagcaaatc cacgcaggtc

105001 tgcaacaacc tcaattcctg cctcctcaga agaaagaatt caattgaggg acgtaagaca

105061 gaaggagaga ctgaggcaag ttttagcaca ggagtaaaag tttatttaaa agctttagaa

105121 taggaacaaa aggaaggaaa gtacacttgg aagagggcca agtggacgac ttaaaaagca

105181 agtgcgtggt ttgacctttt gacttggggt tttatacgtc agcatgcttt cggggtcttg

105241 cgttatttct cccctggttc ttcccttggg gtgggctgtc ccatgtgcct gcctgagccc

105301 actggctcaa ctcctgagat cttataggga aactactgct caccagtttc gagtgttttc

105361 tatctattag gagccggctt ttccctgttg ccgggtgtga ccaattatta ctttagaaag

105421 acagtcaaca accgccagac catcacctga tggtcacctg acactcctgg tgtgtggggt

105481 atggggagcc ctctcctgcc ctgctctttc tgactagcta cccactataa cactcccaga

105541 gggacctgca cattttgtgc tctttgcaag acagtgcctg cccagcacct gtaggcctgc

105601 tcaccccttc agggtcatga tttttgcttt ttaccgcagg tacccataag caaaacatgg

105661 cattgttcac catgctttta cattattcac ataattttaa gttatttaca caacaatgta

105721 aaaccatggt gaaccatgcc acatgttgct tatgggtacc tgtggtaaaa atcctgctac

105781 tagctcattt tgcagtgtct ataatgacag gtaatgctcc attcactcct ttatgacact EPI-109 1130

105841 tgcaaaaact gagaacataa cgcctcccag ttaagcaggc atctgggcaa tgtgaggaga

105901 acagaaatag accacgctgc atttatctct cttgatgaca ggcattgaga tttccacttt

105961 ttctggtttc ttattatgtc tctactgggc attcttacat acatcttgca cgccatggaa

106021 agtttctcta gggcagtggt tcacaaactt tttggataca gaatactttt atgtgcttga

106081 aaactgagga ccccatacag ctttagttta tgtgggtgta aggttctagc ccaaactgaa

106141 gtccgaaggg agttggtggg tgggtgaggg gtagctgaaa aaacacccga ggaatcatag

106201 gcagtttgaa catggcctta tcctctctct gggcacgagc catatgtcca gtgtcagcag

106261 ggtaattata ccttttacag acaatagagg ctctgaagca atcacgagct cacgtgagtg

106321 gtcacctaat gcacctcaag tggcatggtt cataatgtgc ggagtcgtgt gcctacgctc

106381 caaacccact gagtcatggt gcaccaaaaa gtggcctcag cctgctcctg actaaagcgc

106441 agccatcttc cttacactcc acccctaggc caggggcatc ctccaggtag ggacatgtgc

106501 ccgtagggtg gagccctgaa tccataatcc acagcaacaa tacggagagc aacagctcat

106561 gactaggatt ccagctatgc tacttatgac tatcagggcc cagcgtaggc cagagcccag

106621 ggatgtctac catctctgca gggggtcatc agtaaggctc ttgactacct taatctcctg

106681 tgagacccct tgcagggctg ctgttatgtt ctgccaattg tcagggataa aggtacaaca

106741 ttgtgttcct aaaagggcac aggtgcctcc ttaggcagca gttactatgt ctaagaccat

106801 tcggtttcgc aacaccacct ttctgatctg atcaacctca tccattaatg ggaagagggc

106861 cactcaggtg taattcagag cctgagcagc atgctctgca agagcagtaa cttggcttct

106921 acagttgtga cacacactcc agggctagtg cctgtcaagg ggtaaaacca ccagggtgct

106981 cattacactt gcaaaaaccg agagtgtagc acctcccagt tatgcaggca tctgggcaat

107041 gtgagaacag tggcaggtac atgaggccac cctcaggtat aatgtccagt ccagtttgct

107101 tataggtaag gccaccctgt gtccccacag acccataaac tcccaggggg cacacagtcc

107161 atcgaggccc cttggtgggg ccgcgtcttc caccatacct ttggtgtggt gacatgtatt

107221 atgcttacac acactgtgac gggtacccat cccacagtgc tattacccca gtgttgctat

107281 atgcaccaca gtgcctgggc caggggtact gcacgttacc tcactagcca gccccaccca

107341 tcataaatgc tatgggccag ccagggaatg gctgtgctgt gggtcttgtg gcatcctttg

107401 tccaaaactt gccacgttgc gttccaggca tcagccatgg gaccccaagt ctccagccat

107461 gtctggttct ctgcagatgc tgaatgtatg tgctaaggca agccatctgc agctgctaga

107521 agggcggtgc agatccaaca gttggaaaca ttggtcactt cagtgtaggt gtgggcccag

107581 tccacaatgc agttggagca tgttaaccta cagttggaat gacagagtag gcataggtac

107641 taacagagga aaatcacatc cctcaggtaa aatacaggct aacctttcat ccctggataa

107701 caatgcagcc cccaaggggt tctgccctgg gcaatagtac cacacctttt cagctcccca

107761 tggttccttt gggtcctgta ttcatgcgaa agtcacaggg gagcttgtag taggccacac

107821 agacagtaca tttgaaccct ggaggaaagt ttcttccctg gccgttttcc tacaaacagt

107881 taacttcggg gaccattcat tgaacaccca aagagtgaca tacaagtcat actgtaggcc

107941 ctccccacag ggagctacga tggacaacca ccagcagccg ggggcttgga ggggctatgg

108001 ccacagccag gttttctgtt cccctgcctt cagggacgtt ggggcaggca acaacaggtt

108061 actgttcatc cccatacctg gtcagaggcg gttacccttg gtgtgtatct gcaactgaat

108121 aggggtggtg gcccatgtaa caaagcctcc acctgggctg ggctgctttt ccatggccat

108181 tcattcaagg tttggagcat caggtccagc ctggaacttc agccctgcaa agacaggagt

108241 gtgacatgca agtaaaaccc attcttcaag agctcgctat atcactcaat catacccaca

108301 gcttgcaagt tgtgcggtac atggaatccc tactttatgt ccattgttgt gcctgttgtc

108361 cagtaaaatg tgtcccccat cactctcaat gaccaaaggg caaccatata gagcacataa

108421 gtgttgcagg gtctggatgg tgtgctgttg gttggccacc ctgcaaggat aggcaaacaa

108481 caggcctgtg gctgtgtcca cagctgttag cgcatgagta tacccttgtg acttcggcag

108541 cagcccaatg tagtctactt gccacctggt caagggcact tgccctgttg tcacttgtgt

108601 agcactggac agctgcctcc atttagggta tgcctgagca catgccgggc atttctgaca

108661 agcctcccaa atgtcttgca tgggcagaga cagaccccaa catttattga cttgttgcat

108721 cagtttaccc cctgcatgtc ccagtttccg gtgtagctac aaggccacat ctcatgtaga

108781 tgccaactct aaccatcgga ccttggccaa ggcttctgcc tcgtcattgc tgggggtggc

108841 cagaggcata tggcctgaca aatgataaat agttacatct ttgcaatgac ccatttccca

108901 gaggtcttgc tacatgggtt ggtggcccca aatgggttgg tggccaacta gccaattctg

108961 tattttccaa gtagttaaac acaaagttag gcctccatag actgcccagc tatcggtacg

109021 gattaccata ggtgtctccg ccttgttgat caccatccat actgctttaa attcagccca

109081 ttgactactt tgtccacatc tggtttcaaa ccatatggtt ttggtactaa gttggactgc

109141 aacactggtc caagcaggag tagcacctcg actagaccca tctgtgtgcc atgccccatc

109201 aggaatagag ggatgccctt ccttaaatgg cagtggctca gggtcaaggg gtgcctcagg

109261 ccccatggcc ttctcttgca ttaggactgc aggtcccaag acctcttgca actctgctgc

109321 taatgggctt gtgctcagcg tactctgttg ctccaagtaa gtgcctcact ttgccaaagt

109381 ggatgtctgc accatcccag tctggggggt cattacacat gaatgcaccc atcccgctgt

109441 caggtaagtc atccacactg tgactgtagc ccatcctatc acttctcaca agcctgaagg

109501 gcagcatata cagctgctag ctatttctct atcaaggaat accagagctc agctcctttc

109561 catagttggg accaaaagcc tcctggcatt ctcaggcact ctgtgtgctg ccacaggccc

109621 aaactaaaac catctgtggt cacatgcata tccagttcaa atgggcaccc cttgtcaaat

109681 acccacaggg ctcgtgcctg ctgaatagcc cacttggctg ccaggaagcc agtctcagcc

109741 acatcagccc aatcccagat tgctcccttc tttgttaact gatacaatgg ttttatcatt

109801 tgagctaaat gaggcaggaa tgtccaccaa tatcccagga ggctcacaaa agtttgcagc

109861 tgcctcaccg tggtgggcca gggatatgcc taaattttgt caatgatagc ctcttgtatg

109921 gccttcatct tacccgacca gataactccc aagaatttag caggtaatcc aggccctcgg

109981 accttggatt tgttgatggc ccaactgcat gctgccaaat gttgccacaa gaggggtgcc

110041 actgcttcta aatctgcaag agaatcagag gttaacataa tatcatcaac gtaatggaac

110101 aagtggactc cctttggaca ttttcaggct gttaaatcca tggcaacaag accatgacat

110161 atggtggagc tatgcacata gccctgcagc aacactgtga aagtccattg tcatcaaggc

110221 aaactgttcc tggctctcta gagcaaggtc aactgagaag aatgcattgg ccaagtccac

110281 cacatagtgg tactgtccta attccattgt cgagtggttc atcaaatcca tgatagatgg EPI-109 1 131

110341 cacagcttcc aagccatgta aaatatccac ctccagaatg tattcaggta tgggagagac 110401 atacacagtg tataagcaag gagccaagtg gccaatgcca aggtacagag atacaggttt 110461 cactttcact gactggcctc cgtaaccttt aatatatgca gatttgccca aaaacttaac 110521 tgggttccca taaacaaggc tacaatctat gccagtatct accagcacca gcacccactg 110581 tacattggtg ggggaccagt ggattgccaa ttccacatgt ggcctctggt catctggtgt 110641 ccccccaagc cagacacctt tggccagttc cctagttgaa cagaaaaggc tctacatttc 110701 cacctggctg cagcaagtag tctctgagct gggtaggacc aggtcacaca gcaatgcctt 110761 tctccccttt gggcattttc cggaattgct gccctgcata caactgtctc cgcaaagtta 110821 ggagtatttc attgggctgc ttatcaattt tctctcagtc aaccccagcc aaaatcaaat 110881 ctatccacat ctgtgagcgt gtcactcgtt ggggccccct ttttttatgg gggagccccc 110941 tgtgggtggg gtaacttccc cttctttatg gtgtggaccc tccaatcccc ctgaaggcct 111001 tctgcttccc tgagagccgc catggcagtg gttacttcat gtatgcggtg ccctacgtat 111061 ggggtgagga cagcagctag ggagccaaag gggctcagga gcatcaaacc caacatgaga 111121 tccctcatgt gggaggtgaa acatttatca tctggccctc aggtattcag gacaaacata 111181 gcctgccgca tacccatctc ccgaatgact tacaccaaat tggcatatga ctgccattta 111241 ctcacagttt tgggcatttc accagcatta ttccacacag ttcatatggc tgcctgtagc 111301 cactcagtca gggtgtggtc tccttgcgct gccactaacc acctgctcac ttgcagccgc 111361 tgacagagag aggggtgagt catggtggag gccagcttgt ccatctcaga ggtggaatgg 111421 gagataccat ctgctccctt gttccacaga cgaagcatcc aggcaggcag gggttcccct 111481 ggacactggc aacactgctt gcctaattcc tgcaactcag ttggggtaca ggcaatatac 111541 gaaatgtgtt gcattatggt ggggagtccc tgagtccacc cttggagccc cagtggctgt 111601 tcatgatcta ccttctgtca gaccaccggg tgagcccgca acaggggttc ttcctccttg 111661 gtatgaaact gagtggggat ctccagacaa gatgatggac ccaggcctgc attcatggta 111721 gcctctaatt ccttttccaa gctctgaagc cacacctcca ggcatcctgc ctgcacctgg 111781 aggtccccat tcatggcagc ctctaattat tttccagatc ggtgtagcca gacctccagt 111841 ctgcatccct cagggactgg gtgtgtactt ttcttagcac agttaaaaat gcccatccaa 111901 ctctgccagc aaaggctctc tccttcttgg tgctctgcac ttccagctgc ttcagcgcct 111961 tctccatgct catgggggac ccatctactg ccacccaggt ttccactcaa gcccaccctc 112021 acagcacggc taccaccggg taccacaacc catgttgtgg tcacatggcc aacctggaat 112081 cagcagggac cgaaggctca cttaccttag gatcctgttc gtgatgccaa ttgtcaggtt 112141 ctagcccaaa ctaaagtcca aggggagttg gtgggtgggt ggcaggtaac tggaaaaaca 112201 ctcgagtagg cggtttcgac atggctttat tctctctctg ggtgcaagcc atatgtagtg 112261 tcagcagggt aattttacct tttacagaca atagtggctt tgagccaagc acgtgctcat 112321 atgagtggtc acctaatgca cctcacatgg catggttaca taatgtgtgg agttgtgtgc 112381 ctgcctccaa acccactgag tcatgctgca ccagaaggct gcctcggcct actcctgact 112441 aaagcacaac catctccctt agagtgggct aaatctactg ctatttatac tattagaaat 112501 tttaacacag aagttttaaa tatttacatt gttaattgat tttgaaataa taagcccatt 112561 acaggttaac ataattaaca tacttttatt aaaaatatct gtatttttta aaagaaaaaa 112621 aattagcaac aacagtgatc cttggaatcg tcccacctca gcctcccaag tagctgagac 112681 cacaggcgca catcaccatg cgagctaatt tctatatttt ttggtagaga tgggatcttg 112741 ccatgctggc cagggtggtc tcgagctcct aagctcaagt gatcctcctg cctcggtctc 112801 ccaaagtgct gagattacag gtgtgagcca ccacttctgg ccagaagctg gattctctgt 112861 cttgttctcc atccaatctg ttagactgtc aaatgccaaa taacctttgg aaaattctac 112921 tcgtaaaata aggagagaga taaataactt ctgagtatca tcattaaaat agtttgacct 112981 catggaccca ctgggtccca tgtggagaat agctctaagc taaagagtag aatggctggg 113041 aggggacata aacattcagc ccatagctgc tgaccacaat aacacatttt aagtctcttc 113101 ctctcctgct ccttgtgatt gcagacagac tcaatctgta ggagagctgt agagagaaca 113161 agctcaagcc cctgattttg cctacaaaga aagctgagcc cagcaaagtt aagggactta 113221 cccaaggtca cacagccaca cagcagagct ggggctgagc tccaggtgtc ctgctacaga 113281 ggccacttct ttctcccact agggactggc ctgtgattac ttcagaaaac aatggtcagc 113341 taactgattc tgaacgccct ttgctggtaa aagctaatct cctgaggaaa aatgtatgca 113401 ttggctgggc gcagtggctc aagcctataa ttccagcatt ttgggaggtg gagacaggtg 113461 gatcacttga ggtcaggagt ttaagaccag cctggcagtc atggtgaaac cccgtctcta 113521 ctaaaactac aaatattaag ctcggcatgg tggcaggcac ctgtaatccc agctactgga 113581 gagactgagg caggagaatc gcttgaaccc aggaggcgga ggttgcagtg agccgaggtc 113641 gcaccactgc attccatcct gggcaacaga gtgagattct gtctcaaaaa ataataatag 113701 taaaataaaa ataaataaac aaataagtat gcatcacctc aggtggtcag tcagctttcc 113761 caagacccca aagcacacaa tgttctttct ggtatgagtg acatggggtt cacagcacca 113821 caaagtccat gacttttccc tcagaagtga atgcatggct aattattttg tattttttgt 113881 agacatggag ttttgccatg ttgcccacgc tgctctcaaa ttcctggact caagtaatcc 113941 acccacctca gcttcccaag gtgctgggat tacaggcatg agacaccgca tggcctgcac 114001 ctatagtccc agctatcagg aggctgaggt gggaggatca cctgaaccgg ggaagttgaa 114061 cctgcagtga actgtgatcg ctccggtgca ctccatcctg ggcaacagag tgagatcctg 114121 cctcaaaaaa aaaaaaaaag tgaacacaca tgctggggaa gaggcctgca ggcacccctg 114181 ccagttctgc accagagcac actgtagcag ccctgctgtg atgcaggaag cagctccagg 114241 tcctgcagtc tgaagcatgg agcctgaagc ctggagcccc ccatccaatg ctgcgccatg 114301 ctcaccagta tcccccagca tcagcaccga ggcaccagct gcagataaat ttctcaccta 114361 aaatgttgag agatgttgct aaactgtcct tctaagggta tgtataataa tacggtcctg 114421 ccgatactga ataagactat ctgtttcatt acatcctcac aatactgaat atcattagca 114481 acttgaattt taaattgtgc taatcaatga aaatgattgc ctaattacta gtgagttgag 114541 gttatttaac attaatactc cttctgatga aatattttgc atttatcaca ttttacataa 114601 attctctcta tataattagc actagaatgt ccgacttggt tttcattgtt cctcacctgt 114661 ttggaaacac attaagaatg agggagagaa tggatgggga ctcacctagg gatgcatgga 114721 gctggtcggc agccactctg aggccctctt aacacttccc caccacacac ttaatttccc 114781 ctggtttgtc catagataca tccaacaatt tttatαtaaa taagaaagac tcagctttca EPI-109 1 132

114841 atggaaaatg gtaggtt ga ttttatgact gaagtggcaa aaagaaataa gggattttat 114901 tatgggggag gtccaaaccc tggtgaaaaa cgaaattcat tgaaattgtt tgaaaattca 114961 aggattaaat cagattattt tggattcagt aggaattaga ttactttaaa gccccaggat 115021 actttattct gtagaatgca tggaaagtat agaaaagaga aacaaagagg gaaagtcatg 115081 gctaataacc tggaaggggt aaatagggag ccaaaggcct gtgggacgta accaactcag 115141 cattccactg gaggctttat gatcaaatag caagctattt atcatgaatg caggatgtgg 115201 gcaaactcac gactgctccc actgccagaa ggtttgctga gggcaatcac ttcctggcac 115261 cgagctcctt gaggttatct actgggacat ctggagaatg cagtcttgca agcctactct 115321 ggacccagca gctgacccct tcttccatgc ccctcttcct gctatctctt ttgcctaata 115381 aatatggagg gctgtgtaaa gctcagggcc cttgtccact agaggcaaac tgcccgctga 115441 ccccttcttc caaatatgct cttttgtctc atgtctttta ttcccgcttt caccccactt 115501 tgttcagtcc ccctagggcc gtgtgggtta catagtggcg ccctgaacag cgacagaatc 115561 aggtgctcta caagtggcgt ccgaacacag ggactatgag gatgtgaatg aagaagatct 115621 gctggagcag aggaattgaa attgacaagg tgaatgggga tcccgggaca agtctgccgg 115681 cagcagatat aaggtcagtg ccctaaagag gtactgggag cagtgcctta aagtagtact 115741 gggaatggga agttttctga atcagggtaa catggggcag aattggtctg ttgaagaaaa 115801 acattatgtg cagttgctta aagttttgtt gaaacaaact ggtgctcagg ttagttctca 115861 cattaactac gatgctacag gaagtcatta tgcataaccc atggtttcca caggcaggga 115921 ctcttgatgt agaaaattgg gatagagcag aaggattaaa acaggctcat caaaaaggtt 115981 ttcaagttga ttcttcagtt ttctccactt ggagtttagt tcgtactgta cttctgccat 116041 tatctccttg ttattctgcg ggacagcagg ctgaatgtaa aaatctgaaa gaatctgttg 116101 tcccacccac agctccagtt gaaaataagt aataggagag ggaggataaa aattggccta 116161 taccgccccc tccagttgca gaaacatctg taccgcctcc ttcggtggca gaaacagaga 116221 ccccaataca aagaatttta cgctctgccg ccacggctgg agagccctta ggaccttgca 116281 cttttcctat ttccgtaagt cctgatccaa ataatccaca gcagcttaat catgaacaca 116341 ttccactaga gtttaagttg ttaaaggaat taaaagtgag tgtggtaaat aatggcatac 116401 agagcccatt cactttagga ttgctagaat ctatgtttgg tgctatgtgt cttttaccct 116461 ttgatgtgaa acacttggca tgaacttgct tgtctgctag cgcatatctg acatggaatt 116521 taaactggca agaacagggt gcagaccagg ctagacagaa ccatgctgct ggaaatggag 116581 acattacaga ggataggcta ttgggtaatg gcccttattc tgacctggta catcaactag 116641 cactcacaaa tgctgcttat cagcagtgca cacaggctgc taaatgtgcc tgggccataa 116701 ttcctgaaga gggagtccca gtactatcat ttttacatat catgcaaggg tcacaggaac 116761 cctacgcaca atttcttgca agattacaag aggcagtgag gcatcagatt cctcatacct 116821 tggctgcaga aatgctaacc tttactctag cttttgagaa tgcaaatgca gattgtaaat 116881 gtgcactggc accggttagg tgtacaaaaa cttgggaaat tttctcagag cttgttaaga 116941 tgtagcaact gagctttatc gatctgcaat gttagctgaa gcaatggcta atttagctgt 117001 tgacaaatct aaaaagagcc aagggtcaaa ccctaaaatg ggaaaatgtt ataattgtgg 117061 aaaaactgga cattttaaaa aggaacgcca ccagatctca ggacagaaag gatcttacaa 117121 tgcttttccc cccggccccc agcggaaaga acacctggac tttgtcctcg ctatgacaaa 117181 ggaaataact cggctaatca gtgctgctca aaatttcatc agaatggcac ccccctgttg 117241 ggaaatgaga tgggggcctg tacccgggcc tcacaaacaa tgagggcatt cccaattcag 117301 acctcaaccc tgtttcaggc atgggttccc agaggcatat tgagtccctc acccgaggaa 117361 ctccaggaag tgcaggatta gatctcccag ccagagaaag ggttacataa ggtggggaag 117421 acaaacccac caagattctc actggcattt ggggaccttt accagcagga tatatgggac 117481 taattttagg caaaagccac cttaacttgc aaaggcatta ctgtagtccc agaagttgtt 117541 gactctgatt atgaaggaga aattcaagta gttttattgt cacgagatct tcgggttttt 117601 gaaccgagag aatacataat gcaattatta cttattccct gcaaattaca cccttctcca 117661 tgaaaggaga aacaaggaaa taaagggttt gggagcacag ctacacggga aatctatcta 117721 tcccgaccca tagcctctaa tagacccacc tgtgtagtac aaattaaagg aaagaaattt 117781 tatgggttta tggataccgg agctgatgtg tcagtgttac cagcaggtct ttgttcttag 117841 agctcccaag atggcggcaa gccttttgtt ctctgacctg gagttcttgg cctcacagat 117901 tccaaggaat ggatccttgg gccatgcagt gagtgtcata gctctattag aagctcttcc 117961 aaaagtcgtg ctgctatcta tggactaaaa catactcaaa caataatgac ctctggcgtt 118021 taggctcaat gctcagagct aattgcagtc attcaggttt tacagctcac agcttcagat 118081 cctgtcaaca ttgtctgtgt tcagtttatg tcgtaaatgt agccggtcac atagaaactg 118141 ctacaattaa aagtacgcta aacccagaac tgctaattta tttttaagac ttcaacaagt 118201 tatttgttct agtgcagctc cttttcatat ttctcatatt ccttctcaca cacaacttcc 118261 tgggccgcta tctctaagta atgagaaaac agacaaactg attgcctctg tgtttcagca 118321 agctcaacca tctcatgtgc ttctgcacca aaatacttcc gcccttactc acatgttcct 118381 acaggtttgt attatattat gcagtatatc cctcgagcca cacctataga aggatgtaat 118441 ccacgaggtt tggctccaaa tgaaatctgg caaatggatg ttacacacac agcaaccttt 118501 gataagctga gctatgttca tgtgactata gacacttatt ctcatatgct gcctgctaca 118561 tgccaaacag gtgagacagc tggtcatgta cagcgacact gtctgtcatc atttgctcat 118621 atggggatat ctaaacaatt aaaaactgac aatggacccg cttatactag tcatgctttt 118681 aaaaatttct tgcagctttg ggctataacc cataaaacag gaattcctta taatcctaga 118741 ggacaaggca ttatagagca ggcacatcaa acattacaat gcatgttgaa aagacaaaaa 118801 gcgggtatag gaggccaact accacctcaa taaaaactac atttagcctt atttacttta 118861 aattttttga ctcctggtat ggatggtaag actccagcag aaagacattg gcaagtgtta 118921 gaagaaaaga ggaaaattta tccaaaagtg ttatggaaat ccctggaaga aggaaaatgg 118981 aaaggtctgg tggatttact gacgtgggga agagagtatg cttgtgtttt tacaggagat 119041 ggacaagccg tgtgggtgcc ctcaaggtgt gtgcaaccat ggaacgggag actagaggaa 119101 cccagggtgg ccaaccatgg acagggtccc cccggtacga gccatgagcc agctgagcct 119161 gagtgcaaag acggagagaa ggccaactgg agtcacaaca cagttctaat gttatatttg 119221 taaagaatat cactactcaa cttacagttt gtgtttatag atatagatat agatatagat 119281 atagatatgg atatagatat agatatagtt atagatatag atagatatac actttaagtt EPI-109 1 133

119341 ctagggtaca tgtgcacaac ttgcaggttt gttacatagg tatacatgtg ccatgttggt 119401 ttgctgcacc catcaactca tcatttacat taggtatttc tcctaatgct ctccctcccc 119461 cagcaccgcc tcccaacagg ccctggtatg tgatgttccc tgccctgtgt ccaagtgttc 119521 tcattgttca atttccacct atgaatgaga acatgcagtg ttttattttc tgttcctgta 119581 ttagtttgct gagaatgatg gtttccagct tcatccatgt ccctgcaaag gacatgaact 119641 catccttttt tatggctgca tagtattcca tggtgtatcc ttatgtcttt ttgacagcta 119701 agaaggacca gctccaggta aacaataccc aattgacctg taaatcttac caattatatc 119761 actgcattaa tcatagcaca ttgcaaacac ataatatctc tactttgatg attttaggcc 119821 acatccctgg gctatgtatt cctgttaatc tgtccgaggc ttgggctgcc acacctgctt 119881 tgcattttgt gaaacttctt ctaactgagc ttactcatca tgtctgtaga gccttagaca 119941 taataatttt agctattgtt tccttggtcg cactaataac ttctgttgtg atgtcctctg 120001 tagctttgca taattctatt caaacagctc agtacatgga gaactggaca cacacagccg 120061 accaagcatg gctacttcag aataaaatta acactgagtt acaaactgaa gtggtgttat 120121 gggaagtcag ggaccccaaa gagagggacc agctggagcc acagcagagg aacgtaaatt 120181 gtgaagattt catcttaata cggatattta tcagttctca aataatactt ttacaatttc 120241 ttatgcctgt ctttaatctc ttaatcctgt taccttcgta agctgaggat gtgcatcacc 120301 tcaggaccac tgttataatt gtgttaactg tacaaattga ttgtaaaacg tgtgtttgaa 120361 caatatgaaa tcagtgcacc ttgaaaaaga acagaataac ggtgattttt atggaacaag 120421 ggaagacaac cataaggtct gactgcctgc agggtcgggc aaaaagagcc atatttttct 120481 ttttgcagag agcctataaa tgaatgtgca agtaggaaac atatcgctaa attcttttcc 120541 tagcaaggaa tattaatatt aataccctcg gaaaagaatg cattcctgag gggaggtcta 120601 taaatggccg ctctgggaat gtctgtcttg tgcagttgag ataaggactg agatacgccc 120661 tggtctcctg cagaaccctc aggcttacta gagtggggaa aaactctgct gtagtaaatt 120721 tttggtcaga ccagttttct gctctcaaac cctgttttct gttaagatgt ttatcaagac 120781 aatacgtgca ccactgaaca tagaccctta tcaggagttt atgatttttc tcctgtcctg 120841 tttcctcagg agcatgtgat ctttgttctc ctttttgccc tttgaagcat gtgatctttg 120901 tgacctactc cctgttctta caccccctcc ccttttgaaa tccttaataa aaacctgctg 120961 gttttgcggc tcaggtgggc atcacggtcc taccaatatg tgatgtcacc cctggaggcc 121021 cagctgtaaa attcttctct ttgtactctt tctctttatt tctcagccag ccgacactta 121081 tggaaaatag aacgaaccta cgtgaaatat tgggggtggg ttcccccgat atgtgatgtc 121141 acccctggtg gcccagctgt aaaattcctc tctttgtact gtctctcttt atttctcagc 121201 tggccaacac ttatggaaaa tagaaggaac ctatgttgaa atactgaggg tgggttctcc 121261 caataaagtg gtaatgttga aatccacagt tctatggtta ggggaaaagc acaaagcttg 121321 caattgcagc agcaattgca ttgtcatttt aatcacactc atatttgtgt aaccaactta 121381 gaatataacc aaagtgagta tctgtgggac gttgtgaaag cccatttgca gggagctttc 121441 acatctaaca tcacctttga tattggtgaa ttacaaaaca aaattcttga tttacatagg 121501 caaattcaag agtttctgcc ttctttagaa gactggacca aattccagca aggcctggag 121561 agcctcaatc cttggactta tctaaggcac tacattaaca tcttacatgt agttcttgga 121621 ataatattgt tttgtctctg tcttctgttc atagcctgta aaattggatg gaccaccaat 121681 cggaaaatga gagctgccca ccctggcctt acattctttc aattaattca taaacagaaa 121741 gggggatatt tagggagcct aaggctcgtg ggactgacca actcatcatt ccactggagg 121801 ctatatgata aaacagcaaa ctgtttatca tgaatgcagg atgtgggcaa actcacgact 121861 gctcccactg ccagaaggtt tgctgagggc aatcacttcc tggcaccagg ctccttgagg 121921 ttatctactg ggacatctgg agaatgcagt cttgcaagcc tactgtggac tgagcagctg 121981 atcccttctt ccacgccccc cttctcacta tctcttttgt ctaatcacta cggagggttg 122041 tgtaaagctc agggcccttg tccactagag gcaaagtgcc ccctgaccgc ttcttccaaa 122101 tatactcttt tgtctcttgt cttttattcc cacgtttgcc ccctttgttc agtttcccta 122161 ggtccatgtg ggttacatag tggcaacctg aacaatgaca gaatcaggtg ctctacagaa 122221 ataacttttt aaggaaagat ttgggactta gagaccccag gagacataca caaaaatgat 122281 aagaggatgt gcccaaacca gtcttaaagt tgtggcacag ggtgaggaag atgaagctgt 122341 tactgaacct cagagagtga ctggtgttac agcaaaagtt agcaatggcc tgaagggagg 122401 gtttctgaaa tcaaatatga atgattcccc ctcagggaac ccaaccttgg gaactactgc 122461 atggttctct gtatgggaaa atatcattaa tgcaggataa attgtgaaat atcacaggaa 122521 gcatcctgca tctagtcaat cttctgtttc tggggtggcc tgtgcagctg tgcaggcaga 122581 ggcccaacca tcctggtgag tggcacacag ggactgagat ccagccacac ctaccaggcc 122641 atgctctggg aagggggtgg gacctgggca aaggacacct ctctaggact gcacagaagc 122701 ctttgtgggt gggtgggaca ttcctgtgat ggccttctgg ctgggcacta tgaaatgctc 122761 tgaagatttt tccttgcact gttgcactaa ccccagtcct ctatcactgc cccttcctcc 122821 tgggcgactt cactgatgtt gtggccatgt gaattctctg gccaatgaaa tgataaagat 122881 gatatggcct ctgccaagca gacactgtaa gtattattgt atgatgcttt tgtctctttt 122941 tttaaagtta aagcagttta ttaagaaaat aaaggaataa aagaatagca ctccataggc 123001 agagcagctg cctctgtctc ttatattttc ccctctgcct caagcccaac atgcccaaaa 123061 ttggggctgc tggttcagcc tgggtctcag aataaagaca tgagccacag atccattgct 123121 gacccatgat ggagatggac acaagagaga aacacatttt tgtcatgtta gccactaaga 123181 ttttgatttg gaggccattt gctacagcaa tataacctag cgtgaacaga gagacacagc 123241 gatgttccat ttcttttcaa cctggaacag gagaatttca taggtgggcc tcaatttcac 123301 tttagtatct tatttagaca agaaagttca tactgttcaa atgtcatgtt taagagtgct 123361 ggcattatca ctgctgtggc taccccatca gatgttgctc actgactaat cttctcatgt 123421 tagtgaggat ggacaacata tcaggccata attcaaagta gcaaatagga aaagagcttc 123481 atcctagcat tatgggacct taattaatgt cctttcctga caggtttcag aggcttttgc 123541 aggcagcagc agagctattc atctcactga cagtggggaa catggccaaa tggttgcccc 123601 cacaatggag gcagagtttc aggacacttg tctgatctct gcccttgaag gaacagtctc 123661 accctgattg acacttttgc ctgttatgtc caaagaacca atggaaaagc aggaaaatta 123721 ttccttcttc atttctctct tcattattta aaattattct gtcttcactt ctctctcctt 123781 ttctctgctt cctacttagc tctttagaaa tgcaattata atcttttatc tccccttcac EPI-109 1 134

123841 cagacactcc caacagggca agttcatcta actatgtgct cttagttaga cgctacagag 123901 cagaactctc tcccaccaag agactacctt gagacataac agtcaattca caagccaaaa 123961 tatgcccgct atgaaactct cccatctgga aattttttgg ctgcttttac aacctagttt 124021 tgcccacaaa ggcaccagca gtaaccaact caactgcctg gtagacaagg caccaaagcc 124081 agtacccaga ccctctacct gctcacttcc tgccttgcat gccacgcccc ccatttaaaa 124141 gcctctgctt tctgctccaa aggtgaagca gttaccctta aggaaagaag cctgtacttc 124201 ttcccctaag gtagctttgg aataaaagtc actttatacc aaacctagct cttgttaatt 124261 agactctgca agtgatgagc aactgaacct acatttcagt tataattcct atgcttgttc 124321 ttcctgccct gccttgggga cacgcacaca ctcccaggca catacatgca cgtgcactga 124381 gacagctatg tgaataacca acaagatccc cttaggaaaa ccggtgcttg gcctggcctt 124441 aaattccaga cccttgggca tcatacccaa gactgcaaga aagaggaggg gctggacctg 124501 aaaaacttgg aagggaaggt ccaactgtac aggtattttg tcaggcatgt gatttcagta 124561 taaaattcta gaaaagatga gtgacacttt ataaggagag aatatcaaca aaatttctca 124621 ttttacttct tgctaagacg acagcaggga attgtaagca gatggatggg caatccccac 124681 cttcagcagg ggaggccaag gccccaacac acctggggag aagagctggg ggcagtgaat 124741 ggctgaggct ttcttgggga gctgggccat cttcttcggt tttacttcct gaggaattca 124801 caggcttcca ggagggctgt gggacacaac agagcaagag attcagaaac tgatttcttc 124861 cattaaacca gttatttaat ccaataaatc aaagagaata ctaagagttt tctctgccct 124921 tctcccatca ctgagtcagt gcttgccaca ctcatattcc cactccccta ctcctagcga 124981 ctacggtgtt caagggagcc agagtctagc cctcaccagc cagggtgttt ccctgctctg 125041 gcctgagaga cacaaccacc ctgcacttgt ctctgattga atcgactgtc acattctcaa 125101 gttcacaaga cattggtggt cctctagctt ctcccggaat gtgaacctgt ttgcaatcat 125161 gttcacctgc agattcactc attcattcac agatccttac tgagcacctg ctttgtgtga 125221 gttgctgtgc taagtgctgg ggacacagca tggatagact ggcctgccct caagaagcat 125281 gtggtctatg cagtcctgag ctggctgctc acaagaagag ccctgtagcc atatttctca 125341 gagggtggtc ctgacctgca tcacagtgac ctgagttgtt tgtcaataca gaaaagggtt 125401 tctcaacctt ggcactattg acatttgggg cctgataata accctttatt gcagggggct 125461 ggctgtgctt tgtttagtag catccctggc ctctacctat ttgttaccag cagcaccctc 125521 tatgttgtaa gaatcaaaaa aatgcttctc acattgtcaa atatcccctc aggggaaaaa 125581 ttgtctctca ttgaaaacta ccgataaaga catttctggc cctgccccca tccttggacc 125641 aacagcatcc ctaatgcccc caactctggg tgagggacca ggaataggaa tctgaatgat 125701 tgcagtgcac agggagctgt gcacactgaa atcccacagt tatcaccggg agccttacaa 125761 tactctgtga tgtcttctaa atatttttaa gggattaaat taatatcaac atatttccct 125821 ggttaagatg tgttttccta cacttgaatt tttttgagat tttgttttct ctatagttgg 125881 catctatggt aactgtctag aatcagattt tttttttttt ttttttgagg aagggtcttt 125941 cggtgtcacc taggctgtag tgcagtggta caatcatagc tcactgcagc ttcaaccttc 126001 tgggatcaag caatcctcct atttcagcct ctcaagtagc tgggactaga ggtgcttgac 126061 accacaccag gctaattttt aaaattattt ttgtagaaca aggtctctct gtgttggcca 126121 cattggtctc aaactcccgg gctcaagcca tcctcccacc tctgcttccc aaggtggtgg 126181 gatgacaggt gtgagccatc acacctggct ggttttgtca tttctcaatg catatgtata 126241 tatgcacctt tcattttact gaataaaatg gattatcagt ttccaaagat ttcatgacag 126301 tgccgtcact atccgtacta taaaatttat aaaaatttat tacatactgc tctattttat 126361 tctctaatta ttttatcaat gagattataa tttcctgaac tgtaaagaga tattatcttt 126421 ccttaacatt tttacacctg tgttcgttcc tagaatgctg tttggccctc aaaccttgac 126481 cttcacccat ggtggtttct cggggatgct agctagggtc tacttacggg aggttgagca 126541 ctttttcaga ttagtaatgc ctgcgacata ctgtggtccc aaatattttt catatgttgt 126601 tttgccatgg agtctggcca gacactcagt gttgtcattg aacagaaggt ttttggtttc 126661 agactggaat aagcaaaact tgtccgggca gtcagatcca tttctcccaa atttagcctg 126721 cgacaaaagg gcagacagtg agtagctaag gaaaagagga atttgtgggt taaaggaggc 126781 aaaggggtat ttcttccacc caagaacagc cctgagaaaa ccatggggca gaaggagctg 126841 agttctggag tcattccacc tccttagtgg agtcccccac cccacactcc tggtggcagg 126901 cccgccttgg gcagcatcca ggcctcacac cacttctggt cctacctcct accatctgcc 126961 atctttcctt ccttcttaac ctgtgacctt ttcccataca acttcttatg ggtgacaagg 127021 caacaatgga ggggttttga gatctgccct cacaagtcaa ttgctcagga cattctaata 127081 tgcagctctt ctagagaggc aggctgctag gaaaacccag gctcagccac taaccagctc 127141 agtgtgcagg tcggtcaccc tgcctccctc acacagttcc tgctctgtcc caggctccca 127201 tgtggggaga ctgagaccca aacccctcag tcacggcagc tctctcacca gcaccactgt 127261 gtgtgcacat taagagctcc ataaaggcca gttatggtgg ccagtcttgt tattcctgag 127321 ttgttttctt caaaagcaca cagagacatg atgttatatg ataaaaatag aagttctaat 127381 aaaatcccag attttaagaa aattttggga tttcgttcaa atcacattta gagagcccta 127441 aatctatagg gcaccttctg agtttgctgt tttagaggcc tggtctagag cactgttcac 127501 tcggcccagg ttcaggaaat gtcacctgag taaaaagcac tatactaatg catgtgggag 127561 gaaggctcag tggcttcctc atttgccaga agaacagcag gagggaaaaa gacagcctct 127621 gagccaggca gtgatggcaa caaggccagg gcacagagtc tcagcagaaa tggagtgagt 127681 cccagaaagc ccagagtcaa aagcctctgt tgttcttgtt gacactctgg gcaacgccac 127741 agcatgaagc caatactctc accatgagct tcaagtagag gactagagag gatcgagtgg 127801 gctggtgcac ctagctctgt gatctcctca cctaacatga gcccacacag ctaagaaagc 127861 actagaagcc ctgtggtcca tacctgttgg tggagcaaca cctgtttcag gcgttccacc 127921 ttatccatcc gagacaccac ggcatgattc ggggccatgg caagatggca gcttctagcc 127981 tcagtcacag gcttccgttt gccatcgagg cacagcagcg caaagtctgc cagcttcaaa 128041 tccttagccc atgcgtcatt gttatttcct ggggagaaaa agaaggtggc atcatccacg 128101 cctcccctgc ttagccaaga agtctcttct gggtgggtgt ggccattcca ctgacctccc 128161 aaatgcacac actggggttg tggtgatgtg aggaacagag aaggagcttc atcctacaca 128221 agctgtacaa acttcaaata taccaaatat tagtgctgtg tccatgcaat ggaatgttat 128281 tcagcaataa aagggagtga agttctggta catcctgcaa tatgcatgaa cctcgaaaac EPI-109 1135

128341 gatgctaagt gaaagaagcc agtcacaaaa gaccacacaa taggctgggc acggtggctc

128401 atgcctgtaa tcccagccct ttggaggcca aggtgggaga atcacttgaa gctaggagtt

128461 catgaccagc ttgggcaaca tagcaagacc tcatctcaaa aaaaaaaacc caccacatat

128521 tatatgactc catttatatg aaatgtccag aataggccag cctatggaga cagaaagtgg

128581 attgatggtt gccaatgctg aagaaggata gggcaatgac tgataatagg tgcaagggtt

128641 tctttatggg aggatacaag cgttctagag ttggattgtg ttgatggctg cacaactctg

128701 tgaatgtgct ggagatcact gaattgtaca ctttgcatgg gtggattttt tagtatatga

128761 attctacctc aataaagctg tttagagttc ttattttttt aaagaagaaa accctccacc

128821 tatgccatat ttttcagtga gttccagaaa aagaatagat ggtttacatt caaggagaaa

128881 ttggtttctc ctccctttca tattcaaatg ctattagtgt aaccagagaa aggaaaggaa

128941 cttttatagg tttatcaaat atatacagcc aattctaaca aaatacagtt gtaaagtacc

129001 ggagaaagtt aaaattaaat ttgacatcaa tctgatccct ggagattact tcagttaatg

129061 gcttgtaaat tctaaatgta attgtatgca tgtctatgtt tgtgcagatg ccggctcatt

129121 gttccggctc ccgtttgtct ctctgctctc tccctttaag aaagcacttt attcattctc

129181 ttggattcct ctatttgata ttgaaataat ttcaaattta catgtcttgt tttaatctct

129241 gtcccaagag acactagaag gagcagaagc agaagggaga agtggctgag actgcagtga

129301 ttactgaagg agggaggccg aaagtggaga cagttctttc tcaggaaaca gaatagcaag

129361 tcacctgctg agacttgggg gttggaatgc tgaagtgggg ctaaggagac agatgcagat

129421 tggaaggtag caaatggctg aggaccagga gagagagtga ttgttcaaac attggctgga

129481 agattatctt ccatcatctg caaccacctg taattttgtt cccactaact cccaaggagt

129541 ctccagacca aggctcacat ggggatgaat gaaggcctct acttcctttt tcataaaggg

129601 aggcttcatt tgcatatgtt cacccagttt gtagcatcat ccacagtttc caataggcat

129661 gcatgatctc atgtgggcag acagtgtgtt tctgtggttg actagaggaa gccagggaga

129721 catttgctac tgagcatggc tagtatctgt gtgtgtgaga gtgagtgtgt gtgtgtgtgt

129781 gtgagagaaa gagagagagt gtgtgtgtat gaatttcgtt tcaaaatcca tatgacacct

129841 acagatgtta tcatgttgtc tattgagata aagaattttg gagttctttt aatcacaaat

129901 atggaaaatg ttataaaacc ttcccaaagg caaatctgaa cactaagatg tgttgtgatg

129961 ccaaagactc tgctttgaag gagaaaagga aacaccttca cctaccatca gtgttctgca

130021 agacagtgac atctttcaca aatgcaacgt ctccagcatt ctcagccagg cacctaaaat

130081 gttccagaaa atatacacat aattacagaa gagaaactag tggggctttc ataaatattt

130141 gtaatatgca ttccaaaaac tgaaatatgg aagtaaacat ctaaaagaca actatttcta

130201 ggaatttact gtttacagcg gcagattgaa cacaggtgta cctgccctcc ttttaaaacc

130261 ctatataaaa gacattacaa aaccaagaaa tctaaagata tgcgacccag gaaacaggca

130321 atctaacatg aagtaagaca aaggaaagca ccaaaataat ggtcaacagg acccccagga

130381 ccacagatgt gcaggcggcc tacacagcaa ccagtccaaa ctgcagcagg aagatggatg

130441 ccttctggag cagcacttcc aagtaaatga tgaaactgtg atagcaccca gagagagaga

130501 gagagagaga gagagagaga gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt

130561 gtgtgtgtgt atgcatgttg ttaggagatt tacattactg gcagacagtt tggggatgag

130621 atagtgatgt gtttttttaa gtgcagaaaa ttaagcaaat aagaaaagac atttatgaac

130681 tccagagtaa acaaaaagtt tgtacaataa gggaaatata atatgagaat aacgcttaca

130741 cagtcataag tactgaatat gacattagcg tgttgggtgc tgaagagagt tgaagtctgt

130801 ggttgtgtgg tggaaaaggt gctgggggca gtgtgagagg ctagatcttc ttctatacta

130861 cagagtcagc agaaagttaa aaattaagaa ccagcattat aaggatgata gaaataaagg

130921 ggtatgacac tggtttcagc ttttaatgat tttgctataa atttccccaa tctagattct

130981 agatataatt taaacaaaag acaagggatt ttcttccagt ataattagga atattaaaat

131041 gtgggtgttt ccagtgaact aataccttgc tgcaggtctg aaaaaaaaaa aaagaggagc

131101 acatgcttct ttcgggctct tatgagacat gtgttcagca tttctgagta gaatcacatt

131161 tccatttgca aatccttagt cccttaaaga tatttttata cattcacaaa acattttttt

131221 ttgttttggg tcttttttta tgagccactt atatagcaaa agctactttt ctgtcattcc

131281 attactggaa caaggctgtt gaatttatat taaaaagttc agacaccctc agacacatga

131341 cgccatctgg tcgtgaaatg tactcttggc aaatggagga aaaggaacag gggaagatcc

131401 tctctgcacc cttcacactg gtaaatagtg cccctgagaa gcaacacccg gatgaatggt

131461 gctgtaaaac gtggggtgtg gttacaagtc actaagtggt tataacttat gaattctgaa

131521 aacttgtttt ttggcttatt tttcacttcg ttactggaga ataacactgc aattctgcca

131581 tctctttgcc atttctaagg ccaaagtcag agaaaaaggg aaacctaagc catagtcatg

131641 acctaggtga gaagaaaagg ggcggcgatg ggaaagagaa ttcttcccca taaatggaat

131701 tgtaggaagc acttaggata ccacactcta cccatttgat tttcaggacg aggctattga

131761 ggcctactgc tgttgatctt ggctcaaagc cacagggaga agcactgcgg agctgaggtc

131821 agacagccct ggtgccagcc tccactctct ggggcggtgg gtgtggtggg gacagccctc

131881 actggggcca cccatgagct gacccacagg atgaccccca ctctgctgtg acaggtcaca

131941 tctggctcct tagaactgca atgctgacat gctgagggat gaggtaagtc cccatcctga

132001 tggagctcag tcacagactc accggaaagc cccagtgtag ccgtagtatc tctcgttgct

132061 gttgggcacg cacttattct caccctgctc gtcgccaata cacagagcac agagattaga

132121 tctcgggtca gacccagggg cacagctttg actgaaatat tcatctggag agaaggaaca

132181 cggggagtca gctcttcaaa cctgagtcca cacaagcaac ctttacctaa cagccgatgc

132241 agggtggttt cagttcatta gacttcccag gacagcaatc tagatagaac acactcacca

132301 tcacaaagca acatgttgtc accaacatag gacccaccag aaaagcttca ttcagactgt

132361 aggcacagat ggacacccaa ctaaggctgg ggatgagagc tgtggctgcc tggagggtcc

132421 cgtcatcaca gccttgagct ggggactcag ctcatgaccg tgatggctgt gtgcagcaga

132481 gcctgtgagt tgcctagtcc aggatctgat tttgttttta tcagtaatgg aaaccctgct

132541 ttgtatctgg gtgcttggcc ctttggtata aagactagac ttatcagact ccctggggct

132601 catatggcca tatgggtagc tataggccag tgaaatatca gcaggagtgt tgggcgccag

132661 cttctcagaa acatccttga aagacaattg gtacatgcct tttgcccttt cttctccttc

132721 tctttcttca tcctgcacat agaatgcaga agcagggact ggacttagag atgcaatgtg

132781 ggccatgagg tgaccttgag catgaaagcc acacaaatgg cagagtagcc aaatgattaa EPI-109 1136

132841 agcccaggtt ccagacccca tattgtcttc ataccagccc taggcaaacc acctctggac 132901 tacatgacac agaaattaac ttctgtcttg tttaagcctc tactatttca ggagttttct 132961 gttccttgca gctgaacctg atctgaattc gttcattgtg tgatttaacc caagaaagaa 133021 taaacaaagg tgacaagaaa gctctgcccc actgagcaaa cgtcacccat tatcagactc 133081 ccactgctgc tggaagagcc acactatgtg tcaacctcag gaaaagctgg gagttcccat 133141 tccatcctgg cagtttccct acagctcaga ggctgccatg gagctggtga ggagcagagc 133201 cacgtgaaag ctgcctgccc cggccaggat caaaaaccca tgcagtggag cccctgccct 133261 aggagacgcc catacaagaa gggagtcaca ttgaggatgt gctacacacc atgccacggg 133321 gcccacagca ggcagggtgt ggctgatgct gactaggatg agtgtggggt gtggtgggga 133381 gagaaaactg cagaagcaσg tggagccagg ctcttgaggt cttattcagg ctccgttgca 133441 gtgtagagta agcgtcagtt ttgcttagta acaggagtca cctttcatga ggcaggcaga 133501 catctttccc caagctggga agccagagtt taagaggaat ttaggtctgg agctccaaga 133561 ggtaaaaagc atttgcacat cttggaactt gcatttattc ttagggtgca gcgaaatagg 133621 cagatattcc aatctttaat cttggggtgg ggtgaatggg gcatgggaag tgctgtgcag 133681 ggaaaccccc agtgcaccca cgcctccagg gggcagccac agggagaatt tccttatgct 133741 ggaagaggcc tgcaggccac tatcagcctg caaatcccct cccctccctt ccctaaggtt 133801 ccacagcaca atatgcctac cctccagggt ggcccaccca ccgcaccttt ggaactcctt 133861 accaaatttg caggagcccg tctggttgaa gagcaggccc atggggatat tccagcctgc 133921 agtcctgtcc acggcggtgt ggcaggactt cttgcctttc acagagttcc aggtaaggct 133981 agtgtctgat ctcctaacca ccgccacagc aagatatcct ggcataacag atgacagaaa 134041 aacaagtctt aacctccagg aggcctggca catggattcc agtggagctg tctacagccc 134101 aggccaaaac aggccaagaa gcaacaccag gcaatgattc cctcaaagaa ctggcctttt 134161 taggtagacc gagaaagcat aagctgctgc cttatgttaa ggtgagattg atgaaataaa 134221 acagtaagaa aagctgatta ttttagtgat tacaggggac tgtcttcaac cagccacaca 134281 atgtccctga gttacaaacc agcaatgcat ctctcagtgt aagcttctac agcaacaaac 134341 actataaaca acaagagaga ccccaacagt gcataaatca ccaaccacag tgtgcatcag 134401 gcaagagcac caacatccag ccagctaacg gctgtgtggg tacaggggca catgtcccca 134461 gggactgccc tgagctgagt ctgaacccac cctgcactgg ttgaactcaa catggttgcc 134521 gttgtcctcc tgagagaatg catctgacag acacccacca agggcaagtc ttttctgaaa 134581 ctgagcaagc accagctctg gtgggcagga ggagtggtgc acagagcact gggacacgag 134641 tcccaggtca cgaggacccg gggtcaagac caggatctac cacagtatta cctatggctg 134701 tgagtgagat cctgggcact tggggactct cggtgccact gtttcctcat ccccatgagg 134761 tggggaagta gcacccccca ttccatgacc atgacaaaat gagggactat atggatgttc 134821 tttgccaagt gtgaaggtca atataaacat taattagaac tattcctctg tgaattattt 134881 gcacccttaa aattattgct cctagaagcc ctatagcttc tagggctgca attctttctg 134941 ttttttttac agttcctgcc acttcctctt ccagcaacaa gaacttatcc ttgaccctga 135001 aagtggctaa tgccaactca ccttccacag gtctatccac acagttagga tcagggtcac 135061 tgctttgttg ggattctgaa agaataaaga caagccagac atcattatcc attcagatgt 135121 agtgagaagc cacaaactct taaatctcaa tgatgcagaa tcaaatccaa agagaccgtc 135181 ccagcagttc catgcaggag aaatgcgtct atatgttcaa caaaagacat ggcacagaga 135241 ttcacagctg cattattcac cacagccacc aactggaaac tactcaaatg cccatccaca 135301 ctcaaatgat gaataatcac agtagactca cacagcgacg agactgaaca gtctacaact 135361 acacacttag gtggatgaaa agcataacga tgagcaagag aaaccagaca taaaaaaaca 135421 catgctgtgt aattccttta acatgaagtt taaaacatag gcaaacttag atctgcgacc 135481 ttagaagcca ggagagaggc ttcccttgca ggagtaaggg ggcgggggac aggaggacat 135541 aaggggcttc tgaaacttgc agtgtttgtt ctgggcccga gagcatggac tgtacagtgt 135601 gtgaagtgcc atgagttgta catttatgtg cacttttctg tttgtatgtt ataattcact 135661 gagatcttct ggaaaattaa gaagataaaa ccaacctgtc ccttgttaat tctcaacaca 135721 ataggctttg tgggtaacac ggcccctttc atttcttctt tccctgattc tcccttttga 135781 atgtatctgt tcatcataat gtttcacctg cattcaccga atgggattac tcatagcccc 135841 actcccatga cccagaggga atataccaga ggatgctaac tccacttact gtagttctct 135901 gccaggacag gcaccaaacc acatttgcct gcagtgtaca catatcctcc atccaaactc 135g61 atggcatcag cttctccttt ctgcaaagac agagcagatc tccagcacca cagtgaggct 136021 gcatcccgtc ctgcctgtct atatagctct ctgagagaat ggttttctgt caggtgacca 136081 gtgaaacagc agaaagagat ggactattca aactgagcag ccagaggaaa caccgtgtgc 136141 accactaatt ctctcccagc cctgcctact ttctgggctg tcaattcaac tggaaagacc 136201 aggcacaggt tgcactaatc ctctgtcctc tgagcaaaac cttttctgtg tccctggcac 136261 tttggggaca ccttcctgga gcagtctcac tgactgagga cacagatggg aacagctggc 136321 ctcatctaat ctgaactcat tagcactcca ctccaagcgc tacacagaag ttgtccaaca 136381 cataagctga agtcgtcata ttggcccacc accagaatga acaagtccag gctacaacac 136441 aggatcatgg actcatcagt agtatgaaac ttcctctttg acccagtaat atttttacaa 136501 ctatattaaa aatagagaag tggacaaaga tttctactca agaatgctca ccacagggtt 136561 attgataata gcaaagtaag ggacaaagag gaatgggggc atgactaaac tgagccatat 136621 tcacataaaa gatatcctgg aagcatgttt aaaaaatgtt ttcgtccgag tgctgtggct 136681 cacacccgta atcccagcac tttgggaggc cgaagcagga agattgcttg agcccaggag 136741 ttcgagacga gcctgggcaa caaagcgaga ccctgtcgct acaataataa taataataat 136801 tatgcaggtg tggtggcgta tgcctgtagc cccagctact tgggaagctg agatgggagg 136861 atcacttgag cccaagagtt ccaggctgca gtgagatgtg gtcgcaccac tgcactccag 136921 cctgggtgac agatcaagaa tctgtctctt aaaaaaaaaa aaattaatgc tttccaagag 136981 taaatattca tgtggaagaa tgcccattat acgctgttta gtgaaaaggg cttaaaaacg 137041 acatactgca acacttcatt attgttgcat gcatatctgc agatgtgcag agaaatactg 137101 gaatggagaa ttagccagac tttaaccatg tctgtccctc tgtgtgagat cacaggtggt 137161 ttggggggtt tgttgttgtt ttgttttaac ataatacctt tccatatttt ccaaattcct 137221 tataataatc ctgagttgtt cttataacca gaggagtggg aaacccacag taaactgctt 137281 tttgaaacta aaatgctttc tggccctgag cacacctctc caggcatccc tgcctcaccc EPI-109 1 137

137341 aggcccccgt ggcctctttg actgttgact tcactttaag cagatgccca ggccctaggt 137401 cttccaccgg gcccaccgcc cgcccctgtg atggagctcc ctaccagcac cagggcgatg 137461 cagtcctctg tggtggaggc cgaggagcag gtcacgctgc cttcgctcaa gccactccac 137521 tggttacact tgcgcagctc ctgctcgccc accgcacacc acacgacccg cgcacgccgg 137581 gcagccactt cctcctcacc tgccagaggg aagaccgcag gtggctgggc aacctgagct 137641 ttgccaggtt gtccaacctc cccagagcca gggtcctgcc cagactctcc ctggaacagg 137701 agctacagta catgtgtgga catgtggacc cataccctct cctcctccac ttctcagctc 137761 caagcccctt cttcaggtcc acagagctcc ctgtgtttcc cacttctgtt cctttggaga 137821 agttccctgg cttctaatct atccattaat ctttagagtc aggaggcgcc tattgtctct 137881 gtctctgagg ataaacgctc catgacccag agaccagtga cagtcccaag agatggccta 137941 ggggaccttg agcccaaccc tgacttcccc taacgcctgc aatcaccacc aataactacg 138001 gtgcagcctc tgggttcccc cagactccca cccccagccc cccagtagag aaggagccat 138061 agctgagttc ccccaccatg gtgtccccaa ctaagttcaa ggtctgggcc tgggaagtgt 138121 gggtaaatcc aggcccccgg attcatccag gaggggtcct ggctatcttt gttcatgttc 138181 atgtttctca cttaatagga ggcaaactga tttttctgcc aggcctgggg agcctgacgt 138241 gcactgatca ggtggccaga ctattctttt agagacacct gacctaatcc acagaagaca 138301 ctcacacctg catcaaacct ccacgatgac cccacagtgt ctgggaaaag gagtgaccgc 138361 cacaaagtag ggccacctgc tgggaagtag aagaccacac caggcggacc tcaggaccct 138421 cctgggctca ctcacttttc ctcaagttct ggatggcagt gaagtagccg gagccaaggt 138481 acagcccaga atctatcctc gggggcaccc tcgaaaaccc aatggcagag tccttgaaca 138541 gcagatcttt ctgcccacta ggggagccaa agagctggaa tttcggtgac ttgtcctttc 138601 caaacttttc ctaattaaga aaaaatagaa ttatggtgtc aatggtaaat agggaggaaa 138661 caaaaaaatg atgttaaaaa agagtatctg gagctttggg atcattctaa ctgagagcag 138721 gagcctcggt tgagaccctc ctgcagaggg acttgtgcca tctcggagac ccaagctcag 138781 ctatggctca ttctttgaag agttgctgag gtccaagcac cttagggccc tgagaagatt 138841 gcatcgacca ccccctgctt ctgctcccat cataagacgc tgtcagcccg tgtgacagaa 138901 gagtttcatt gcttctgctg tccacagtac agcctgggca agcagcccaa tgcattagtg 138961 tgctatcctg cagcaaagct acaggacttc tggagtggca gaagtcaggg aagtaagaaa 139021 ccttgctccc tgccccccat atccaagcaa gtggggagga ccgtgggtga agatacctgt 139081 gcctggcgga gaagattcca gatggcatcc tccttgccat tcacacttcg tgccacaacg 139141 gcatgagaag ggacccgggc cagatggcag tctttgaact tgtccactgg cttccgagtg 139201 ttgtctgggc agagtaactc atactcgtcc ctttcagcct cgtctgacag gtcctctgca 139261 gggaaggtga ggtgggaggg agtctagata agccgactcc agcagtaacc tcgagctata 139321 gttccccttc tccctataga attttgagct tggggagata gctgacaaaa ctgagggtca 139381 gaaaggcagg ggtttgctcc agaacactca gaaaggtaaa ggtagtgccc caaaagcctc 139441 agggggcagc cgaggtgtga tcctcatcct aaatcactta ggccaccctg gggttcccgt 139501 gcagctgctg cctggcaggc cagagaggcc aaaccagacc cgtctgtttc tgcggcatct 139561 ctgcctggaa aagtcacttt gcagagacaa gctcaggggg ccaccaaggg ttgctccctt 139621 actcacatct ctgggaagaa taaaaatgac aaaaatgtta acaaggcagg gaataaggca 139681 ggaaggtgag acactttcca acactgagta tatcaaaaga aggggaagaa tggttttatg 139741 aatgagttca ggcaaatgtg gaatatcata tataagttgc ttcagaatgt gtaaagtgaa 139801 aaaaatcttg cccgagtcat tttatgagat tagtacaacc ttgatgtcaa aatcagaaaa 139861 agtataggag ggaagaatta aaagtttatt ttacttacga acataaatgc aaaatttgta 139921 aataacgtac taactaactc aatctcacag agtatttaaa aagctaatag attggaatga 139981 aggtttacca gtgtattcca ttaacaaaag aatggctgaa catcaaaaaa actaaagtaa 140041 tctgcattta atggcagaaa accatgagat cgtcttcatc ttaatagatg cagaacgatt 140101 gtttatgtgt tcaacatcta tttgtgtgtg gttttttttt cagcctcaga aaaatagtaa 140161 tagatagaat cggtaaagtt tttttgtttg ttttgagacg gagtctcact ctgttgccca 140221 gcctggaatg cagtggtgcg atctcagctc actgcatcct ccatctcctg gagtcaagag 140281 attctcttgc ctcagcctcc caagtagctg ggaccacaag cgcacgccac caggcccagc 140341 taatttttgt atttttaata gagatggggt ttcaccatgt tggccaggct ggtctcgaac 140401 tcctgacctc atgtgatcca cccgcctcag tctcccaaag tgctgggatt acaggggtga 140461 gacaccacgc ctggccataa gttattggct tgataaatgc cattaatcta cagcaaaaac 140521 cttactaaaa gaagaaaatg tagacattca ccgcaaaatc aggaacaagg caaggatgcc 140581 cactgttaca atgccagcac aattctagat atccagatca cacaatttac aaaagaaatg 140641 tgagatataa acactggaag gaaaaagaca cactcttatt taaaaagatg atatcgtcat 140701 ctacaaaaaa ccaatgaaac caacagaaac taataaaact actcagagga gtaacaagtt 140761 ataagagcaa cctacaaaaa tcagatgtta tcctcattaa caataaccaa atagaaacca 140821 atatggacta taagatgtta caatagcaac taaaaccatt aagtagctaa taattagcct 140881 cccacaaaga cacatcagac ccacaaagga aaaattttag ttctatcaaa gaaactaaaa 140941 agaggtgtga tcaaatgggg gagatttagc atcaccatgg actggacaac ttaatgttat 141001 aaatatgctg atttttcatg gaacaattta aattcagtac aattcgaatc aaaattaaag 141061 tatgattttt tccagaaatt caacaaaata attctgaagt tttagctgag tatatttgaa 141121 aaggaataat aaagtgagag gggagaggga gctctctctc attctctctc tcttcctctc 141181 actggctctc tctctttctc tccaccagat agtaagaccc attggtaagc cacagtaaca 141241 aaagcagaaa aaatgcaaat acaccaatga aataaaatag ctcagaaact ggtccacttg 141301 gatatataca aacttggtgt agaattggct tcacatatgg cagaaaaaat atactttttt 141361 tattgtaagg taaattgcct cactgtaaag gggataaaat gctaaagcca aatctatatc 141421 tgactttcta ggtagagcac atataaatag atgaggaagg ggatcttcaa atcttatttt 141481 aggaaataat tatgatttgg gtgtgaagaa gggcatcttt gaaatatctc aaaactacaa 141541 accaacaagg tgaggcttgt ggatttgacc ttatcaatat caaggatttt tgatcaacag 141601 agactaccgt tgtcagattt ttgactgaga agaggtttta ctaaagttta aaatcagcaa 141661 tagtttgata cctagataga aggaacttct gtccttgaat caaaatcatg cagaaacaag 141721 gtgtgaaact caatttaaaa agtagtcaaa tgtcacaaaa taagaaaggg aagcccaaac 141781 ggctagcaaa tatgttgaaa tgatcaaact caccagctgt cagagaaatg aaaattaaaa EPI-109 1138

141841 ataaaacgaa ctatctattg cattacaacc atcattcgga caaaaagtat gaaagtcaaa 141901 aatacttcta actgaagttg tggggaaatt agaacacttg cagagtgtca ttccagacag 141961 cagcttggtg atcctgggtg catgtggggt ctgtctctgg tggccatggg tgcatgtgga 142021 ggtctgtttc tggtggcctc tgatgaatgc ggggtctgtc tctgatggtc ctaggtgaat 142081 gtgggtgttg tctctttctc tggtggtcct gggtggatgt ggggtgtgtc tctgatggtc 142141 ctgagtgaat gtgggtgtct gtcactttct ctagtggccc tgggtggaat atagtagccc 142201 tgtctctatt ggtcttgcat gaaatgtagt gagcttatgt ccactagtcc tgggtgcagt 142261 gtgtttagcc tctacatact catcaactgc tttattataa gtccaggagg gacgctgtcc 142321 agcaggtaag taaggaacac aggtgaaggt atcagtcgtg tggctgcatg tggtagagga 142381 aaagagagca caacctctgt ccatcactat ggtgacagag aagtaaaagg tggatgtatt 142441 ccacggaaca ctcctcaact gttaggaccc ctgagctaga catgtataca acaataccga 142501 taaacctcta aaacaaaatg ctgagcagaa aacccaagta gcaggatttc taatgctcac 142561 taaaacctct atgaacccag aaaccggaaa cacaaaccag cacaatctgt tctgcatgag 142621 cacatgtgtc ttggaggact ggaggacgca ttgccaagca cctaggcatg ggtgtctatg 142681 aggggaagag aaaggcagta ggcacaggag gtttgaagaa aactgatcat ttaaaatatg 142741 aaagatcata aaatcagagc tgtgccctgt aggaatcttg aaaatggtct gccatgaact 142801 taggaatcta attagctcaa aggtcagagt catgatcaag taagataaaa ggggtcagta 142861 cccacggctc attaccctgc tcttaccaaa cactgtgctc tctctgataa aagccacgtc 142921 tccagccccg tctctcagac acctgtgaaa agagaaacca tcaggggtaa gcacaggcag 142981 ccctccccag cccctccctg tggaacagta gccctggcac tcagcatcta tgggtttcta 143041 ctccctgcag ggcagggctc tgaagctt

(2) INFORMATION FOR SEQ ID NO:25: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 149412 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 25: 1 tctagagcca aggtcacgga agcccagagg gcatcttgtg gctcgggagt agctctctgc

61 tgtcttctca gctctgctga caatacttga gattttcaga tgtcaccaac caccaagaga

121 gcttgatatg actgtatata gtatagtcat aaagaacctg aacttgacca tatacttatg

181 tcatgtggaa aatttctcat agcttcagat agattatatc tggagtgaag aatcctgcca

241 cctatgtatc tggcatagtg tgagtcctca taaatgctta ctggtttgaa gggcaacaaa

301 atagtgaaca gagtgaaaat ccccactaag atcctgggtc cagaaaaaga tgggaaacct

361 gtttagctca cccgtgagcc catagttaaa actctttaga caacaggttt tttccgttta

421 cagagaacaa taatattggg tggtgagcat ctgtgtgggg gttggggtgg gataggggat

481 acggggagag tggagaaaaa gggggcacag ggttaatgtg aagtccagga tccccctcta

541 catttaaagt tggtttaagt tggctttaat taatagcaac tcttaagata atcagaattt

601 tcttaacctt ttagccttac tgttgaaaag ccctgtgatc ttgtacaaat catttgcttc

661 ttggatagta atttctttta ctaaaatgtg ggcttttgac tagatgaatg taaatgttct

721 tctagctctg atatccttta ttctttatat tttctaacag attctgtgta gtgggatgag

781 cagagaacaa aaacaaaata atccagtgag aaaagcccgt aaataaactt tcagaccaga

841 gatctattct ctagcttatt ttaagctcaa cttaaaagga agaactgttc tctgattctt

901 ttcgccttca atacacttaa tgatttaact ccaccctcct tcaaaagaaa cagcatttcc

961 tacttttata ctgtctatat gattgatttg cacagctcat ctggccagaa gagctgagac

1021 atccgttccc ctacaagaaa ctctccccgg taagtaacct ctcagctgct tggcctgtta

1081 gttagcttct gagatgagta aaagacttta caggaaaccc atagaagaca tttggcaaac

1141 accaagtgct catacaatta tcttaaaata taatctttaa gataaggaaa gggtcacagt

1201 ttggaatgag tttcagacgg ttataacatc aaagatacaa aacatgattg tgagtgaaag

1261 actttaaagg gagcaatagt attttaataa ctaacaatcc ttacctctca aaagaaagat

1321 ttgcagagag atgagtctta gctgaaatct tgaaatctta tcttctgcta aggagaacta

1381 aaccctctcc agtgagatgc cttctgaata tgtgcccaca agaagttgtg tctaagtctg

1441 gttctctttt ttctttttcc tccagacaag agggaagcct aaaaatggtc aaaattaata

1501 ttaaattaca aacgccaaat aaaattttcc tctaatatat cagtttcatg gcacagttag

1561 tatataattc tttatggttc aaaattaaaa atgagctttt ctaggggctt ctctcagctg

1621 cctagtctaa ggtgcaggga gtttgagact cacagggttt aataagagaa aattctcagc

1681 tagagcagct gaacttaaat agactaggca agacagctgg ttataagact aaactaccca

1741 gaatgcatga cattcatctg tggtggcaga cgaaacattt tttattatat tatttcttgg

1801 gtatgtatga caactcttaa ttgtggcaac tcaaactaca aacacaaact tcacagaaaa

1861 tgtgaggatt ttacaattgg ctgttgtcat ctatgacctt ccctgggact tgggcacccg

1921 gccatttcac tctgactaca tcatgtcacc aaacatctga tggtcttgcc ttttaattct

1981 ctttttgagg actgagaggg agggtagcat ggtagttaag agtgcaagct tcccgcattc

2041 aaaatcggtt gcttactagc tgtgtggctt tgagcaagtt actcaccctc tctgtgcttc

2101 aaggtccttg tctgcaaaat gtgaaaaata tttcctgcct cataaggttg ccctaaggat

2161 taaatgaatg aatgggtatg atgcttagaa cagtgattgg catccagtat gtgccctcga

2221 ggcctcttaa ttattactgg cttgctcata gtgcatgttc tttgtgggct aactctagcg

2281 tcaataaaaa tgttaagact gagttgcagc tgggcatggt ggctcatgcc tgtaatccca

2341 gcattctagg aggctgaggc aggaggatcg cttgagccca ggagttcgag accagcctgg

2401 gcaacatagt gtgatcttgt atctataaaa ataaacaaaa ttagcttggt gtggtggcgc

2461 ctgtagtccc cagccacttg gaggggtgag gtgagaggat tgcttgagcc cgggatgatc EPI-109 1139

2521 caggctgcag tgagccatga tcgtgccact gcactccagc ctgggcgaca gagtgagacc 2581 ctgtctcaca acaacaacag caacaaaaag gctgagctgc accatgcttg acccagtttc 2641 ttaaaattgt tgtcaaagct tcattcactc catggtgcta tagagcacaa gattttattt 2701 ggtgagatgg tgctttcatg aattccccca acagagccaa gctctccatc tagtggacag 2761 ggaagctagc agcaaacctt cccttcacta caaaacttca ttgcttggcc aaaaagagag 2821 ttaattcaat gtagacatct atgtaggcaa ttaaaaacct attgatgtat aaaacagttt 2881 gcattcatgg agggcaacta aatacattct aggactttat aaaagatcac tttttattta 2941 tgcacagggt ggaacaagat g

1 agaagagctg agacatccgt tcccctacaa gaaactctcc ccgggtggaa caagatggat

61 tatcaagtgt caagtccaat ctatgacatc aattattata catcggagcc ctgccaaaaa

121 atcaatgtga agcaaatcgc agcccgcctc ctgcctccgc tctactcact ggtgttcatc

181 tttggttttg tgggcaacat gctggtcatc ctcatcctga taaactgcaa aaggctgaag

241 agcatgactg acatctacct gctcaacctg gccatctctg acctgttttt ccttcttact

301 gtccccttct gggctcacta tgctgccgcc cagtgggact ttggaaatac aatgtgtcaa

361 ctcttgacag ggctctattt tataggcttc ttctctggaa tcttcttcat catcctcctg

421 acaatcgata ggtacctggc tgtcgtccat gctgtgtttg ctttaaaagc caggacggtc

481 acctttgggg tggtgacaag tgtgatcact tgggtggtgg ctgtgtttgc gtctctccca

541 ggaatcatct ttaccagatc tcaaaaagaa ggtcttcatt acacctgcag ctctcatttt

601 ccatacagtc agtatcaatt ctggaagaat ttccagacat taaagatagt catcttgggg

661 ctggtcctgc cgctgcttgt catggtcatc tgctactcgg gaatcctaaa aactctgctt

721 cggtgtcgaa atgagaagaa gaggcacagg gctgtgaggc ttatcttcac catcatgatt

781 gtttattttc tcttctgggc tccctacaac attgtccttc tcctgaacac cttccaggaa

841 ttctttggcc tgaataattg cagtagctct aacaggttgg accaagctat gcaggtgaca

901 gagactcttg ggatgacgca ctgctgcatc aaccccatca tctatgcctt tgtcggggag

961 aagttcagaa actacctctt agtcttcttc caaaagcaca ttgccaaacg cttctgcaaa

1021 tgctgttcta ttttccagca agaggctccc gagcgagcaa gctcagttta cacccgatcc

1081 actggggagc aggaaatatc tgtgggcttg tgacacggac tcaagtgggc tggtgaccca

1141 gtcagagttg tgcacatggc ttagttttca tacacagcct gggctggggg tggggtggga

1201 gaggtctttt ttaaaaggaa gttactgtta tagagggtct aagattcatc catttatttg

1261 gcatctgttt aaagtagatt agatctttta agcccatcaa ttatagaaag ccaaatcaaa

1321 atatgttgat gaaaaatagc aaccttttta tctccccttc acatgcatca agttattgac

1381 aaactctccc ttcactccga aagttcctta tgtatattta aaagaaagcc tcagagaatt

1441 gctgattctt gagtttagtg atctgaacag aaataccaaa attatttcag aaatgtacaa

1501 ctttttacct agtacaaggc aacatatagg ttgtaaatgt gtttaaaaca ggtctttgtc

1561 ttgctatggg gagaaaagac atgaatatga ttagtaaaga aatgacactt ttcatgtgtg

1621 atttcccctc caaggtatgg ttaataagtt tcactgactt agaaccaggc gagagacttg

1681 tggcctggga gagctgggga agcttcttaa atgagaagga atttgagttg gatcatctat

1741 tgctggcaaa gacagaagcc tcactgcaag cactgcatgg gcaagcttgg ctgtagaagg

1801 agacagagct ggttgggaag acatggggag gaaggacaag gctagatcat gaagaacctt

1861 gacggcattg ctccgtctaa gtcatgagct gagcagggag atcctggttg gtgttgcaga

1921 aggtttactc tgtggccaaa ggagggtcag gaaggatgag catttagggc aaggagacca

1981 ccaacagccc tcaggtcagg gtgaggatgg cctctgctaa gctcaaggcg tgaggatggg

2041 aaggagggag gtattcgtaa ggatgggaag gagggaggta ttcgtgcagc atatgaggat

2101 gcagagtcag cagaactggg gtggatttgg tttggaagtg agggtcagag aggagtcaga

2161 gagaatccct agtcttcaag cagattggag aaacccttga aaagacatca agcacagaag 2221 gaggaggagg aggtttaggt caagaagaag atggattggt gtaaaaggat gggtctggtt 2281 tgcagagctt gaacacagtc tcacccagac tccaggctgt ctttcactga atgcttctga

2341 cttcatagat ttccttccca tcccagctga aatactgagg ggtctccagg aggagactag 2401 atttatgaat acacgaggta tgaggtctag gaacatactt cagctcacac atgagatcta 2461 ggtgaggatt gattacctag tagtcatttc atgggttgtt gggaggattc tatgaggcaa 2521 ccacaggcag catttagcac atactacaca ttcaataagc atcaaactct tagttactca 2581 ttcagggata gcactgagca aagcattgag caaaggggtc ccatataggt gagggaagcc 2641 tgaaaaacta agatgctgcc tgcccagtgc acacaagtgt aggtatcatt ttctgcattt 2701 aaccgtcaat aggcaaaggg gggaagggac atattcattt ggaaataagc tgccttgagc 2761 cttaaaaccc acaaaagtac aatttaccag cctccgtatt tcagactgaa tgggggtggg 2821 gggggcgcct taggtactta ttccagatgc cttctccaga caaaccagaa gcaacagaaa 2881 aaatcgtctc tccctccctt tgaaatgaat atacccctta gtgtttgggt atattcattt 2941 caaagggaga gagagaggtt tttttctgtt ctttctcata tgattgtgca catacttgag 3001 actgttttga atttggggga tggctaaaac catcatagta caggtaaggt gagggaatag 3061^' taagtggtga gaactactca gggaatgaag gtgtcagaat aataagaggt gctactgact 3121 ttctcagcct ctgaatatga acggtgagca ttgtggctgt cagcaggaag caacgaaggg 3181 aaatgtcttt ccttttgctc ttaagttgtg gagagtgcaa cagtagcata ggaccctacc 3241 ctctgggcca agtcaaagac attctgacat cttagtattt gcatattctt atgtatgtga 3301 aagttacaaa ttgcttgaaa gaaaatatgc atctaataaa aaacaccttc taaaataaaa 3361 aaaaaaaaaa aaaaaaaaaa aaa 1 aagcttcagt atgcaaattt tcaatgacat gtgcctgtgg attctgaaaa ttcacagatc

61 tgtctatcct tagctgagac tgaaggcatc tacttcccaa tgaccaaatc ctggtgctgt 121 ggcgacactg agcaggaact ccattagaat atcaatatca ctctgcagac attccatgat 181 gtaagctatg ttttctcttg ttgcaattac acttaattta ccaccagctg cttcaatgtc EPI-109 1 140

241 atgggctatc ttgaaaaatg aagctccttt cgtagtcaaa ctggatgcaa gacacagcaa 301 atgagaagtt actaaattgt tggagtcctc atagctactg cctgctttaa tgaacaaacc 361 aattcttgat gcagggcata gttttccaaa ggagaaatca taaaaccatt tggaaatttg 421 atgatctcaa ggtcctgatg atgtggagcc actcctatgg gggtagctgt ggctttaact 481 ttgggggcaa ctttgaggga ataaagtctc aaaaagaggg aataaagtct caagattgtt 541 cgtgacccat agtaacttct ggcttaaagg accattcggc aagtttttaa atgtattttc 601 tataatttcc atgtagttct ttatattttc tatttcttat ttaaaacctc tattttagct 661 cgtttccttt gacactgctc tggcagggaa aggggtggca ctgcctcatt actgccaggt 721 aggggtagaa gtccattatc cacttggtct ccattgatac ccaaagtggg gagaggctcc 781 tgttactgct ggtgagggtg ggagtccccc cactaagttt ctgctaatac tgtcctggtg 841 gcttgctact attcccatga agcctccact gatactacat tacttttggg tggtggcaaa 901 tgtcctgcct ctccactagc cctcctgctc taaaacaacc cgagtaggga gtgggaagga 961 agctttgtta ctggtaggtg ggagctgaag tccagacttg ccacattgtc ccactgatgc 1021 tacagggagg aggaagcggg ccacattact gcctgatagg gatgaaagcc ccagctccct 1081 acctggcctt cgctgatacc agcctgctac aggagtgaag agagatttga aggcctcaat 1141 atagcctgtc gagggtggaa gtcttgctcc caatgggcct ttagcagcat gggtgggtgt 1201 ggggccatag ctgtctctgt actgcttggc tagagtggag tatttgaggt ccaaaagttt 1261 tctgtctttc tagccctttg gttagaaaga gcagactttt gttggaagta tttttttgtg 1321 tttacctgtt gtatttccag gttcctagct tctccagcac agtctgggat gtgtgagaca 1381 cagagaaaat ccagtgatgt tactaccgta tggtttcttg ggtcccaacg tctctagcta 1441 atctgctcca ccttttggag ttttcttatt tgttttagat cagggattta gtcatattta 1501 ataggagaaa tatggaaaaa tacttctact ctatcttcct ggaagttcct gtttattttt 1561 tatgtccttt tcctctggct agaccgtaag agacttacga aacaaacact tacacattct 1621 actaaactca atgtccaaag tttgtgaact tcttgaatat tgcttgttca tttccacccc 1681 cagtcactga ctgaatctcc ctgctgtctg tctacaatgc caatgagctt ctggttaact 1741 tcttctcatg catgcttagg caacaacttc ccagttttac tacacttgcc catccctagt 1801 tttgttgttg cttaatccct tggcctagtg ccaccatact cctccagcag agcaaccaat 1861 tcttacatta taggacagca catatccact aaaaacagtt catgccacac caaccacatt 1921 tccctttgtc aacaaaatta cttgatagat aattccagga atgcctgatg aagctgattg 1981 acaacaagat atttggcaga ctctctgctg cctatacata ccttagcatg tggaactcaa 2041 gtaatgagag gtccatttaa ttggattgaa ttgggctgga taggattgga ttgaatcctg 2101 tgggatggct aggctaaatt agaaatgaag actagtttaa cagcagtatc caaggatagt 2161 tgactaatga gttaatttta ctctcaaaga cagtctttag tagtaagctg taatgcatta 2221 tatcaaacta ttttccagtc aatgatttat aagttacttg aataaggatg ctaaagatgt 2281 gccttattga aatggcaatt agcacaaagt tgggaatgaa atctaattag ttaaataaca 2341 gaatcacata aaaaaggact tgaataaatg tagcatccta ccatgttcct ggatagaaag 2401 actgctatcg taaagatatt cattctcctc aggttaaatt ataaactcaa tgcaattcaa 2461 caggatttta aaaaactaga caaagtgatt ccaagtttac gtggaaaata aaatgtgagg 2521 gaccaaacaa tatttgaaaa agaaagagaa taaaatctca tccttccaga taccacaatg 2581 tattataaag caatagtaat taacatgagg gcagaaatga gcaagcaagt gaacaaaata 2641 agacagatag tcacaggaaa ctcatatatt tataggtgct ttgcgtataa tgaagatggt 2701 ccttcaaatc agttgggaaa agatgggtta ttcaataaat ggtgttgggt aaaattggtt 2761 atacattggt gagaaataaa gtgaaactcc tactttgtat catatgcaaa aaatagattc 2821 cagacagatg aaatatttaa atgtaaaaaa taaaattcta aaactactag aaaaaaaaga 2881 agaatatttt tattcctttg aaatagaaaa ggtcttacta agcaaaacac agaagtaata 2941 aatgaataaa tgaagacaaa tatgataaaa ataagttaaa aatataagca atctttcttt 3001 gttttttttt cacctttcct agaaaaaaat atataggcaa cttgttaagc aaggtagatt 3061 acaagaaaat atttacaaca tttgacaggc cacagattat tatccagcct catctgataa 3121 gaaaacttca acataaagat atctgttttt tttcttataa ggttcctcaa agtgagccaa 3181 tcacttctta agctgaacaa aaaacaaaac agaagtgatc ttttccaata atgaaaacaa 3241 acattgacag agcagctgta ggatcctttc aggcaaatta tgaaaaggtg ccctttctca 3301 gaaaccacag ttaccattca gctttgtgac cagaggtttg actgtaccct agtccctact 3361 agcaacccaa ccacataacc aacttcaaag gtcctgaatg actgtgttgt acttaatggc 3421 agatgatcta tctcccattt ttgtcctaag gattttccaa gataatatat ttctgcattt 3481 gttttgcttt tacttcactc caaattgaaa tctatttgtg ggataagact aaagaaatgc 3541 ttataggaaa attgatagca ccaaattcct atcttaaaaa atgaaaaagg tttcaaatca 3601 atgacctcag cttttacttt aagaaaatag aaaaagcagg ataagctaaa gccaaagtaa 3661 acagaagaaa ggaaattata aagataagag cagaaatcaa tgaatagaaa acaaaagaaa 3721 aaaatcaaac caaacagctg attctttaag cagatctata aaattgataa aactctagcc 3781 agattgatca agtaaaaaag agagaagaca caaattacca gtattaagaa tgagagaggc 3841 aatatcacta cagatcctac agatataaaa agtataaggg catactttga ataattttat 3901 gactataaat taggcaactt agataaaaca aatttcttga aagacacaaa caaccaaagc 3961 tcacctaaaa tactcacaaa ttgaatagtc ttatagctat tacaaaattg aggccaggcg 4021 cagtggctca agcctttaat cccagcactt tgggagggct aggaaggcgg atcacgaggt 4081 caggagtttg agaccagcct gactaacatg gtgaaaccct gtctctacta aaagtacaaa 4141 aattagccag gcttggtggt gcgtgcctgt aatcccatct actcaggaga ctgaggcagg 4201 agaattgctt gaacctggga ggcaaagttg tggtgagccg agatcgcgcc actgcacttc 4261 agcctgggca acagaacaag actccgtctc aaaaaaaaaa aaaaaaaaaa aaattgaaat 4321 tatagttaaa agtcttccca caaagcaaac tctagaccca gatggcttca atggtaaatt 4381 ctactggaca atcaaacagg aaacagtaat aattctccac aatgtctttc ataaaattga 4441 tgcggaggag atactctcca actcattcta tgaaactagc attaccctga taccaaaatc 4501 atacagagac agtgtaggaa aacaacagat cagtatcctt catgaacata aatgaagtac 4561 aatgcagtct tatgcataaa tcagagcttc attgttctac agataaggta atgtaggatt 4621 gttggttgcc cctccaggtc tgttaaattc acctccttcc ccagagagca tccttcttaa 4681 ggacagggag cctcaatatg tcagtcctca cagcacctcc ctcagtcttc agcacttacc EPI-109 1141

4741 agctcatcac cacaaccgat accacattgg ataatttcat gaattacttt agagcaaatg 4801 caagagaaaa aatggatttt tatataggag aagaaggagg aaattcttgt ggatttggta 4861 cagaataggg ccaagggaaa attacagatg taaaaagaaa agtgtgtgaa atagtatcct 4921 tagtgctcac aaatacaatg atttcattgt ttttaaaaat aaaaaatgac aaatgtctaa 4981 tgcttggtgg taatgcttta ttgaatgtgt gttatacact ggttcctcat tcctgaagtt 5041 agaaataata ccttcctctt ttcatttggt tatgtttgct gaaacaaatc aaaggctgag 5101 attgaaacac atgctacttc aggtggatga ccttactact aagctcatca caacagcact 5161 tacagctgaa gaccccagag tcctacctaa cttttgtcac aacccagatt ttggccatgt 5221 agttctgggc cttaccatta aagcagacag aagtcagagg aatgactcct ttccacttga 5281 agtgagctgc aggcttctag gaaaggcaag atgcacattt ccctcctgtg gagcataaag 5341 cctttgtaat tcaggactta ggacccatat ggatttgaaa tattatgaca ttggagctgg 5401 agtggttggg gacaacacca gtagtgttat aggccatgga atgtcaaaag aacatggaac 5461 cctgttaaaa tcattaaaca tcaaaactct cccctcctct ggtgatatgg tttggctgtg 5521 tccccatcca aatctcatct tgaactccca tgtgttgtgg gaggcaccca gtgggaggta 5581 attgaatcat gggggcaggt ctttcccatg ctgttttcac gatactgaat aagtctcaca 5641 agatctgatg gttttataaa ggggagcttc cctgcacaag ctctcttctc ttgtctgcca 5701 ccatgtgaga catgcctttc accttccgcc atgattgtga ggcctcccca accatgtgga 5761 acttttaagt tcattaaacc tcttcctttt gtaaattgct cagtctcaaa tatgtcttta 5821 tcagcaacgt gaaaacagac tatctgattt tctgtgggat gtggattatg accatggaca 5881 gagcataact gggacagagc tggaaaaaat attaattagg tgcttaaaaa tatttgttag 5941 aactatcttc atgaatgaga atcaatcctg tttccatggt gattcaccag gcatcaattc 6001 caagcatcca tgaatcagaa aagtcctatc ttctcttagt tatcatccag gactccaagg 6061 aaccataatt agccaacctg ttcacatttc cttttcattc actagcctcg aagtttccag 6121 gggacaggga ctctgtccta ttcatttctg taaccttacc acctgaccca gaatagctgt 6181 tccctgaaga tttggtggat tataaatgtg gatgtcttat ttctttgaaa gtgtgagctt 6241 caggtactga tcacgttatt ccaattatca atttagtatc tttcttcacc attaaactgt 6301 gaaattcttg agggaagaac ctatgactga tttatctctg taaactcatg ccaccagtat 6361 tcaaaatcac acctagcaca tagtaaacac tcaatgtttg ttgaatgact gaaggaatgg 6421 atgaaaatga acctccttgc ttctgaccag tggatgagtt gcttggccgt gttcctacag 6481 cctagagctc atcccctaaa gcatctgaag ttacccatta gtgcaatggt tcttgaacgc 6541 tggtgttgat cagaatcatc tggatgccca ggttctctga aataagatag ggtctaggca 6601 tttgtatttt taccaaggag gtgtgatgga gtcagatgca agaaggctag ttgaagaaac 6661 cacatgagag tttagtgtag tgtattagaa gactggtttg gctctgtcgc tagtggctac 6721 atcatcttgc tcaagtcatg ccagtctcag gacctcattc agtctcttca gctgtaatat 6781 gggtgggttg caccacataa ccagaaagat cccttccagc tctacccact tacaacatgg 6841 tcaaatttgg tctgattttt taaatcgtag tacaatatat atgacataaa attcaccatt 6901 ttagccactt taaatgtaca attctgtagc attaactaca ttcacattgt tgtgcaacca 6961 tcactaccgt ctacttccag aactcttcat cttgcaaaac tgaacctctg ttgtcattag 7021 tcactaacta ttcctctccc cccctccttc taggccctgg caatcaccat tctactttct 7081 gtcgctatga atttgactac tctaggtaac ttatataagt ggaatcacag catttgccct 7141 attatgactg gtttagttga cttagcacaa cctcctaagg ctcaaccaca ttttagcatg 7201 tgtcagaatt ttctttgttt ttaaggctga ataatattct gttgtatctg taaataacat 7261 ctttattcat ttgtccatca acagactgtt gagttcctcc catcttttga ctattgtgaa 7321 aaatgctgct atgaacctga gtgtacagac atctggttga gtactgcttt caattcattg 7381 tttatatgga tcatatggta attttatgtt taattttttt ggaactgcta cattgttttc 7441 cacagtgtac atcattttac atttccatca gcaatgcaca aaggttccaa tttctccaca 7501 ttcttaccaa cattttttat tttctgtttc ttatttattt gtttatttat tctgagacag 7561 agtctcactc tgtcacctag gctggagtgc agcagggtga tctcagctca ctgcaacctc 7621 tgcctcccat gttcaagtga ttctcctccc tcagcctccc aagtaaatgg aattacaggt 7681 gcccaccacc acgcccaggt aatttttgca ttttttttag tagtgatgag gtttcaccat 7741 gttggtcagg ctggtcttga actcctgacc tcaagtgatc cacccgcctc agcctcccaa 7801 agtgctggga ttacaggtat gaaccactgc acccaggcca ttttttgctt tttagataat 7861 agtcatccta gtgggtatga agtggtattt cattgtggtt ttgatttata tttccctaat 7921 gatcagtgat attgagcatc tttcaagtgc ttattggcca ttttcttctt tggagaaatg 7981 tctatgcaag tcctttgctc attttttaat ccagttgctt tttgttattc tttttgattt 8041 gaaagtgttc tttatacctc ttgtatacta atcccttatc agatatgatt tataaatatt 8101 ttcttctttt ccatggattg ccctttttac tctgttgata gtgttctttg atacaaaata 8161 atttttaatt tgaatgaagc ccaattaatc tatttttgtt tcttttgttg cctgtgcttt 8221 tggtgtccta tccaagaaac tgttgccaaa tccaatgtca taaagctttt tcccatgctt 8281 ccttctaaga gttttgtagt tacagctctt gtatttaggt atttgactat tttgagttaa 8341 tttttgtaca tcgtataaaa taagaatcca atttttattt tattttactt tttgtatgtg 8401 gatatccaat ttccccacca ccattcattg aaaagactgt ccttttccta tcgaatggtc 8461 ttggcaccct tgtaaaacat aatttgacca tatatgtgag ggtttatttc tgggctctct 8521 attctattct attctattct attctattct attctattct attctattct attctattct 8581 attggtccct atgtctttct ttattctagt accaccattt tgctcatcat aactttgtag 8641 taagttttga agtcaggaat cgtaagacct ccagctttgt tcattttcaa ggttgttttg 8701 attattcaag gtcccttgat agtccatatg aatttcagga tggatttttc tatttctgca 8761 aaaaaaaaaa aaaaaaaaaa aaaaatcatt gaaattttta aacagattgc attaaatctg 8821 tagattgttt tgggtagtat tgacatttaa caacattaaa tcttccaatc aatgaactag 8881 gctattttta tttatttttt ctgtttcttt gagctacttt tgtagttttc agtgtataag 8941 tttttgctac ctggttaggt atacttctaa gtattttcta ctttttgatg ctattgcaca 9001 ttgaatcgtt ttcttaattt ggtggtagcg gggattgtgc attgttagta cataaaaatg 9061 caactcattt tttgtgtgtt gattttgtat cctgcagctt taacaaattc atgttagttc 9121 taacagactt attctatgaa tcattagggt tttctacata aaagatcatg tcacctacaa 9181 acagagataa ttttactcca ccccttcccg ttgcaatgcc ttttatgtct ttttcttgcc EPI-109 1 142

9241 taattgttct ggctaagact tccactacca tgttgaatag aagtggtgaa agtagacatc 9301 cttgtcttgt tccaatctta gagccaaagc tttcagtctt tcacggcctg aaagactttg 9361 taatatgttc tcaaggttaa agaacttcag aagttttcta agcaagagac cattttatta 9421 acttagttgg cagcaattct gagagattag aatgaaaaga tagaggataa gaagtatctg 9481 gcaggtataa tatattgagt gtgctgaata tacttttagt tttgtatagg tgttaaaaaa 9541 tggcaaagga ggccgggcgt ggtggctcac gcctgtaatc ccagcacttt gggaggccga 9601 ggcgggcaga tcatgaggtc aggagatcga gaccatcctg gctaaaacag tgaaacccta 9661 tctctactaa aaatacaaaa aactcgctgg gcatggtggt ggacacctgt agtcccagct 9721 actcgggagg ctgaggcagg agaatggtgt gaacctggaa ggtggagctt gcagtgagcc 9781 gagatcacgc cactgcactc cagcctgggc gacagagaga gactccgtct caaaagaaaa 9841 aaaaaatggc aaaggaaaga atgaaaaata aagcaaggtc ccagaagagg ccaaaaatct 9901 taatcaaaat tgactgaaca ttacggaatg aaatggtttt tcctttactc caattaacga 9961 cttcacaaga agattccatc ctcgtttata agattaaccc aaaaccagca cttaaaacca 10021 gaagccttga aaggatggag tttggggacc cttctcatgt ctattcccag aagggggtct 10081 tcttctgggg tcctgtcccc taaagagcta ggcaaaaagt atgcttgcca catctgttga 10141 aagatagaaa gttggtctaa aaatacatga gagggaactg aaacatttca gagaaggcaa 10201 gactcagaag taagaaacca aaagaggaag gtaaaattct agttacaaag aaaagaggaa 10261 tggaaattaa attgtcttac agagaaaatc cagaactgcc ccctcttccc ttactactcc 10321 atcaaaaaag gggaaaaata gtcaatggga aagttttgag aaaaatagat ctctgcattc 10381 ttctggttga gaattcagac aacttgaact agagagctgg gtaatttctt gactaaaggt 10441 gtgttagatc tgaaagggtt tttcttaaaa ttgtctgtgt tcatccctcc catcttagag 10501 aggaacacag gataagagac ctctggagct cccccagggt caccgagcta ataggatcag 10561 agacaaagct acaaagtcat tttctgacat ctctccaggg ctcttttttt ctggaccccc 10621 catatcaaca tgatgtattt attacattgg attagcaact ctccttgagc tttcctcagt 10681 accaggttta catctcagtc tgtgggtctc agagaaagta cccaatcagc agcaacatta 10741 cctggaaact catcagaagt gcccctcctc agccccaccc cagatctatg caatcagaaa 10801 ctctggaaat gcaggccagt cctaacaagc ccaccaggga attctggtgc actaaggttt 10861 gagatccact gatcaaagaa ataatattcc ttttcttcat tataatagca tgaataataa 10921 ctaacatgta tttcacaatt tacaaaagag ctttatgctc ttgttaaatt tgagggtagt 10981 cttctcaaaa tctctgtgag gctagaaagt cagatattga aacacctgtt ttatgggttc 11041 aaagataggt tcaaaagaga gtaaatgatt gttggggtgg caggtccaga gagggcagga 11101 tcaaaactgc aattgagtct tctgccttat aaaccagcat agcttcccca aggcacgtca 11161 cttctcgata aaatggtgac aactagagtg tcctttcaga tcattcttag aagcatggag 11221 tgctaggtca attgtgtaat tgatgaggaa ataataatac taagaactcc catcttctac 11281 gtccttatat acaatcctgt caggtagaag ctgagtctca gagagaacaa gttgccctcc 11341 caggaccacc aggtaagctc ggcatagctg tgcttagaat gtaggctgtc tggcttctgg 11401 gcttgcctgc ccagggaggc tttgtgggtt ctacttggtc atccagatca cagaggggca 11461 gcactgactc ctacccagtg ctcttgactg tacatctaat actttctact aagaaaaccc 11521 cttctcttta gaccaatggt tttcaaatct tggtgtgcat tggaatcacc tggaaagctt 11581 gttaaaacac agattgtccc accccaagag tttctgattc tgtaggctgg ggtggggacc 11641 catgaaagtg catttctaat aaggtcccaa gtgatgctga tgccaccagt gtgtggacaa 11701 ccctttgagt ggtgaagctc tggacaccct aatttgcaag gctaatcagg catatgtggc 11761 aaatgaatac gaactgaaat tctgactcca atatcttcac tgatattcct aatccatagc 11821 atacacacag tcccattcgt ttccctttta gcttttaatc tacatttatc ctttcttcct 11881 ctgccactgc cttctctcca gttagctcaa accaggtaac acataaccgc ctcctaactc 11941 atccgcccag ttggtttctt tggctttaat ctagacttct tatctccacc agatttgcct 12001 taccaaagca ccaatttctt aaggcagggt tagaattaaa aatcttctgt tcctcctcat 12061 tgcctaaaac tcctaaactt atgattcaag gtcttccatg accttcatgg accagtctaa 12121 cgttttagcc tgtcctaagt gacatgcctc caccacatac ttcatgcttt ccactttctt 12181 tctccatgtc tttgttcatg catttccatt tcttctacct gcgatgtcct ccttcgccat 12241 ctctgtagat ttaaaaatcc tacagggctc atctcaaatg ccctttcctt catgaagcct 12301 ttcatgaaat ccccatcgag aggttttccc tcctctcagc tctccaaagc acagatgtct 12361 gcgtttgtgg ctattatctt acgttgtttt gtattaaaat ttctccagct ttacacattt 12421 gtcatcctct taaggacaaa catcttatta tggtcaatgt gaagctatag aggataattt 12481 aatgaaatat tccaagggct agtcattaca catgactgat ttatctctgt aaactcatcc 12541 acactcatcc acctgatttt gattggccaa gttaatgaat cagagaggaa aagatggtaa 12601 aaatataata aaaatctcct aggtagtctc acatcccaca gagccccagg taatgaaatg 12661 aggccctgag ataatacttt atgaacaata aaactccggg ttctattgac agtgaagcaa 12721 gacctgagag agaaggctaa attcccttgt gtctagctgc cacaatcttc tgagaataat 12781 ggcctttctt cccgtctgcc ttctgaatca taggcaaatt tttctctttg gtgatcccta 12841 atacagaaag gggaagtcaa ataaaatata tacaaggaga aggattctgg gagacagagt 12901 ttcttgattc ccttctgcat gctcctcctc aaaagccttt atgagcttac cttacattta 12961 aattctttta aacaaggcat tatgtggtct ggtcttttcc agctccacac accttcacac 13021 tacattcccc ccagctaatt ctgctctggg aacactgacc ttcttttagt tctttgaaca 13081 cattgatttc tggtcaagat gactcagtaa cttcaacctt tgttgtgccc ttggtgctgt 13141 gaagatatag atatatatta accactgcac accagaaatc agaaatagca caacagagaa 13201 taaagtcatt gagccatctt ctgagctcca aaagacaaat tttctccaaa aagacaaatt 13261 caggctctaa aacaatacct taaggaacca gaagtggaat agaaaattaa ggtggtaagc 13321 agggctaaac cacatgcctg ttgagcccag gtttggaaga agacaatggc aggtaggaat 13381 gtggtttctg atgggtaata ggtactgttt tcatttactt tctgttgctt ataacagaat 13441 atctgaaact gggtgcttta taaagaaaag gaatttatgt cttgcagtta gggaaactga 13501 gaagtcaaaa gttgagggct gcaattgaca agtgccttct tgctggtggg gatactctga 13561 agagtcttga ggtggtatcg ggcataccac tctcagtgag gggactgagc atactaggtc 13621 aggtctttct tcctcctttt ataaagctat cagtcccact cttatgataa cccattaatc 13681 cattaactga ttagccaatt aatccatgaa tggattaatt cattcatgag ggcagagcct EPI-109 1143

13741 tcctgaccca aacacctctt aaagactcca cctctcaata ctgccacatg ggggattaaa 13801 tttcagcatg agtttttgat gagacaaata ttccaatgat agcagttatt aaaagtacat 13861 gcttgagaga aggggattgg agtcagcctc agtgcttaaa ctcaaaagct aggatgaggc 13921 tctaacactc ctgaaagaag gagttgctgc tggctcctta ccagggctat atcttttaca 13981 gagcaggaga cctaaagagg caggaggacc cggacatcgt ttggaaacca agcactaaaa 14041 caggccatct gttatacccc caatatcctc tcaggacaag tgttttgaac cactcacaca 14101 aggactagtc tgggcaagtg ggctagatga agaaaccaca aaatagctaa gtggggagag 14161 aaagaccaaa aatactattt tattcaaaat gaaaatacaa tccaaaattc catgattcat 14221 gaagaaatca aatggtatgt gttaggtggt tcttgcattg ctatagagaa atacctgaga 14281 ttgggtaatt tataaagaaa agaagtttaa ttggctcata attctgcagg cttcacagga 14341 agcatggtgc tggcatctgc tcagcttctg gagaggcccc aagaagattt gctcaaggca 14401 gaaggttaag ggagagctgg cacatcacat ggtgagaaag gaagctagag agagagtgca 14461 gggtgaggtg ccacaagtta ccacagccag atctcttgag aactcactta ctttcatgag 14521 gacagcacca agccataagg tgtagggagc caaagtccca tgggacatga ccaactcagc 14581 attccactgg aggctatatg atcaaacagc aaactgttta tcacgaatgc aggatgtgag 14641 caaactcaca actggtcctg ccaacagaag gtttgttgga ggcaatcact ccctggtgcc 14701 tgaggtaatc tactgcaaca tctagagaat gcagtcttgc aagcctactc tggacagggc 14761 agctggcacc ttattccatc ccccttctca ctatcttttt ttgcctaata aatacagagg 14821 gctgtgtaaa gctcagggcc cttgtccact agaggcaagt tgccccctga ccccttcttc 14881 caaatatact cttttgtctc ttgtctttta ttctcacatt tgcccccttt gttcagttcc 14941 actaggtccg tgcgggttat atactggtgc cctgagcagc aacagaatca ggctctcaac 15001 aagtgtcatc cgaacatggg actttgagga catgaacgaa gaaggtctgc tggagcagag 15061 gaacagaaat tgacaaggtg aacagggacc ctgggacgag tctgccagca gcggatataa 15121 ggtcagttac ctaaagaggt actgatcagt gccctaaaga gatactggga gcagtgcttt 15181 aaagaagtac tgggaatggg aaattttctg aatcagggta acaaggggaa gaatttgtct 15241 attaaagaaa aacattatgt gcagttgctt aaagttgtat tggaacagtc tggagcttag 15301 gttaatttgc agacactaac tatcacatgc gtccgtgtga agagagtcca ccaacaggct 15361 ttgtgtgggc aataaagctt tttaatcacc ttggtgcagg tgggctgagt ccaaaaaagg 15421 agtcagcaaa gggagataga ggtggggcag ttttatagga tttgggtagg tagtggaaag 15481 ttacagttaa aagtggttat ctcttgtggg cagaggcagg ggtcacaagg tgctgggtgg 15541 ggaaatcatg agactctttt tctgggacag gagtgtcaca aggtcaattg atcagttggg 15601 gtggggcagg aacaaatcgc aatggtggaa tgtcatcact taaggcagga actgactatt 15661 tcacttcttt tgtggttctt cagttgtttc gggccatctg gatgtatagt gcagctcaca 15721 ggggatatga tggcttaggt tgggctcaga gacctgacat tcctatcttt ttatattaat 15781 aagaaaaaca aaacaaaata gtggttaagt gttggggcag caaaaatttt ttggggtggt 15841 atgtagagat aaggggcaat gtttctcagg gctgcttcaa gcacgatcac ggtggtgtgg 15901 gaatctagag tgggagagat taagctgaag aaaaattttg gggaaagggg tgatattctg 15961 gggttgttag aaggagcatt tgtcatatag aatgatgatg gcctggatgt ggttttgtat 16021 gaattgagaa actaaacgga agacacaagg tccaaataag agaaggagaa aaacaggcat 16081 taaaggatta agaattggga ggacacagga catccaatta gagagtgccc aagggggtcc 16141 agtgtaatta tttgcctgga caatgagttt tggggctcta ttaggttgtc atataccagg 16201 ccagattgat ttaggtaaaa acaacactct tcatttaaaa tatacagagt cctccttttt 16261 tagcagtgag taagttgaga cctattcctg tcttcttata ttaataagta aaataaagca 16321 aaatagaggt gaagtgttgg tgtcatgagg ggaacaggaa gcagttcggt cctatttgca 16381 aattgatttt gggggggtaa agaaaactag tgtacctttg cctgtccaat taataagtag 16441 acacatgtag atggaggagc cacagaggaa gaagagaact ttgtaaggca aaactggaaa 16501 tgtaaaggga aaagatgaga gggagcacca aaagaggtgt cttgcaccca gactcaggga 16561 tctagtgaga gcagcagctg ttagaggttg taatggggat taatggggct actgggtaga 16621 gggggaggtt caacttttat ggtgtatgag aaagcgcata gtgtctacaa gcaacctttc 16681 attgctattc ataggattgg gtataagtaa acaagaaggg ggggctagga ggagagtctg 16741 aagaacaagg ggaaggtagc caaggatgga gtgaaatgta gggcaaatgt cttaaaggaa 16801 atgagaggtt ctaagaggag ggctagtggc ttgtaaccca catggaagag gttacgaaag 16861 gatgatagaa tggaatgagc ctgtgaggct ggaaggagga attttccttg gtccaagaac 16921 catttgcctt gtgtgggaag agtttgatag gtggaagttt cagtgggagg gtaggcggga 16981 gtgactgatg agaaggagaa aaactggcca taagggacag aagttggaat gctagctgct 17041 cctttagcta ccttatcagc ataagctttg ccctgagtga tgggatctga tgccttttga 17101 tggcgcttgc agtgaatgac cctagcttcc ttggaagtag agcagcttta agaagagttt 17161 ttatgaagaa ggcattaata atggaggacc ctcgtatagt gaggaaacct ctttcaggcc 17221 atataacaga atggaggtgg agaatatgga aggcatattt agagtcagta taaatactga 17281 cacacaatcc ttttgcaaga gtgagggctc gagttaaggc aatgagttcg gcttgctgag 17341 agggagtgga gtggggcaga gtggtagcct caatgataga tgtgaaagat actatagcgt 17401 agcctgcctt tgctggtgag tggtgattag gcctagtgga actgccatca ataaaccaag 17461 tgtgatcaga gtgaggaaca ggaaagaagg aaatatggga aaatggagtg aatgctaggt 17521 ggatcagaga gatacagtca tggggatcag gtgtggtatc aggaataatg tgggaggcca 17581 gattgaagtc caggccagga acaatggtaa ttgtgggaga ctcaacaaag agtgagttca 17641 actgaaggag ccgggggagg gggagagcgg cagaaagtat atgcatcagg tgtgaggaag 17701 aaaatacatt ttgaaagtta tgagaactgt agagagtgag ttgatcatag tttgtgattt 17761 tgagggcctt taaaagtatt aaagcagtgg cagctgccac acacagacat gagagccagc 17821 ctaaaacagt aaggtcaatc tgtttagaca gaaaggctgc agggcactgt ccaagctctt 17881 gtgtaaggat tctgaccgca cagccttgta ctttggctgt gtgtaatgaa aagggttggg 17941 atgagttagg gagagctagt gtgggagtag cttctagggc tgtttttaag gaacataaag 18001 aggagtgggg aaaggattta ggatctatgg ggtcagctag gtttcctttt gtgagtttat 18061 gtaatggttt agtcaggatg gcaaaaccag gtatccaaag gtgaaagtac ccaaccatgt 18121 ctaggaagga aaggatttgt tgctttgtag aagggattgg ggtttgggag attagccgga 18181 cacagatcag gagggagagc acttgtattt ttatgaagaa ttatgccgat aggtaacgga EPI-109 1144

18241 tgaggaagaa atttgggctt tggaggggga tacacgatat tcccttgaga atagatgttg 13301 gaggagcagg agggtgtcct gttgggaaga ttcataggag gggctataaa gtagaaggcc 18361 atcaaaatat tgaataaggt gacaagcaga tggacagaaa agtaaattat gagaaagggc 18421 ttgactgaag taatggaggc tgtccctgaa gccttgtggc agtacagccc aggtaagttg 18481 ctgagactga tgggtgtcag ggtcagtcca agtgtaagtg aagagaggct ggggtgaaga 18541 gtgcaaagga atagtaaaga aagcatcttc aagatccaga acagaataat gggttgtgga 18601 gggaggtatt gaggatagga gagtatatgg gtttggcacc acagagtgga taggcaagac 18661 aatttggttg ataagctgaa gatcctggac aggctttagt cccttcaaag cctgttgtgg 18721 gatgggatac tggcattgag caggataagg gtaattaggt tttaatggga tggtagggtt 18781 gcgtgatcgg tcaccaagga gggagtagag gtatcccata cttgtgggtt aagataggga 18841 gtcaggaggg gaggttgtga aggaggcttt gaactgggga aaagggtggc aatgaggtgt 18901 ggctgtagcc caggaatagt cagggaagca gataatttag ttaaaatgtc tcaatttaat 18961 aagggagctg ggcaggtggg aataactaaa aaggagtgca taaaagaatg ttgtccaagt 19021 tggcaccaga gttggggagt tttaagaggt ttagcagcct gaccatcaat aaccacaaca 19081 gttatggagg caagggaaac aggcccttga aaggaaagta atatggagtg ggtagcctcc 19141 atattgatta agaaagggac agacttaccc tccactgtaa gagttaccca aagtgtctgt 19201 gatgatccag gaggcttctg aggtgatcag gcagtgtcag tcttcagctg ctaagctgag 19261 aagatctggg aaggagtcag tcagagagcc ctgggccaga gttccagggg ctctgggagt 19321 ggctgacggg caagttggac agtccgattt ccaatgcggt cccacacaga tgggatacag 19381 tttaggagga atcctgggct gtaggcattc cttggcccag tggccagatt tctagcactt 19441 gaagcaagat cctggaggaa tgcctgacca cagtggttta ggtgttttga agttcttgtg 19501 tgctggagat gtggctgagg tttttctcac agcagaggca agtaattgca actcagaaat 19561 acattgccac ttggctgtct cttctctatt attgtacacc ttgaaggtga ggttaattaa 19621 gtcctgttgt ggggtttgag ggccataatc taatttttga agctttttta atgttgggag 19681 tggattgggt aataaaatgc atattgagag taagacagcc ttctggcccc tctgaaccta 19741 gggcagtaaa atgtctaaga gttgttgcca aagggaccat ggactgggct gcgttttcat 19801 atttgatgaa aaaaaaagag cctaaatgct aactaatttg ggagaggtca gataaagtaa 19861 aaggaacatt aatcttgact atgccttcag ctcttgccac ctctctaaga ggaaattgtt 19921 gggcaagtgg aggagtgcta gtcgtggaat gaaaccataa gctggactgg gtgtgaggag 19981 gggaggtgat agaaggatta cagcgtaggg gagtagaggc tgaggaagaa ttgggacctg 20041 gctcagcctg gtgaggagtg gcctggtgag gagcagcctg gggaggagga gagaggttag 20101 atgggttcgt agaaaagaag gattcaaagg actcggagct tggtgaggag actgaaggaa 20161 cagacaggag agaaagaaga aagatttggg acaagtcgca ttgggagcag agactaggaa 20221 gggagtgatg tgtaaagaat gcctggacat caggcacctc agaccatttg cccattttat 20281 gacaaaaatt atctaagtct tgtagggtgg agaaatcaaa agtgccattt tctggccatt 20341 tggaacaatt atcgagtttg tattggggcc aaatggtgtt gcagaagaaa ataagatgct 20401 taggttttag gtcaggtgag agttgaagag gttttaggtt ttttagaaca caggctaagg 20461 cagaagaagg aggaatggag ggtggaaggc tgcccataat aaaaaggtaa gtttagagaa 20521 aagagaggat agagacacag agagaggggg tggtggtact catcagccag gggaggtggt 20581 acttgccacc aaggtgatgg atcaaggcag tcatccccac ggtgatcaga cacctctgaa 20641 atgtgggtga ataatcaggc aggtgtccct gcagtgatta gacaccaagg ggagactgtc 20701 ttcccgagtc cgtgaccggt gctggagttt tgagttcaca gataaaacac atctcctctg 20761 tctctaccag aaagggaaag gaactgaaat taaggaaggg agagattgaa gggtggagag 20821 atagcaagag agttggaaaa gagaataaaa agaggccact tactcaattt aaaattggtg 20881 agatgttcct tgggctgatc tgaggaccca aggttgtagg tggatctcct cacggaatga 20941 gggtgaggac aggggactgg tctccagaag gagttcccga gtcctggatc ttcagcacca 21001 aatgtcatgt gcatccatgt gaagagagtc caccaacagg ctttgtgtta tcaataaagc 21061 tttttaatca ccttggtgca ggtgggctga gtctgaaaaa ggagtcagca aagagagata 21121 ggggtgggtc agttttataa gatttgggta ggtagtggaa agttacagtt agaggtggtt 21181 atctcttgag ggcagaggtg ggggtcacaa ggtgctgggt ggggaaatcc tgagacttat 21241 catccaggga aggagtgtca caaggtcgat tgatcagttg gggtggggca ggaacaaatc 21301 gcatggtgga atgtcatcag ttaaggcagg aactcactat ttcacttctt ttgtggttct 21361 tcagtttctt caggccatct ggatgtacac gtgaaggtta cggggatata tgatggctta 21421 gcttgggctc agaggcctga cactaacctc ctgcagaagc cacaaaaggt tattacacat 21481 aaaccatggt ttccacaggc aggcactctt gatgtggaaa attgggatag agcaggatta 21541 aaacaagctc atcaaaaagg tcttaaagtt gattcttcag ttttctccac ttggagttta 21601 gttcatactg tacttctgcc attatctcct tattattctg cggaacagca ggctgaatct 21661 aaaaattgga aagaatttgt tgtcctactc acagctccaa ttgaatataa aaaacaggag 21721 agggaggata aaaattggcc tataccgcct cctccagatg cagaaacatc tgtaccatct 21781 ccttcagtgg cagaaataga gatcccagta caaagaattt tatgctctgc tgtcatagct 21841 ggagagccct taggaccttg tgcttttcct atttctgtaa ggcctgatcc aaataatcca 21901 cagcagttta ttcatgaaca ctctccacta gaatttaagt tgttgaagga attaaaaact 21961 agtgtggtca ataatggagt acaaagccaa tggttcctgg aggaaggaat gctagacata 22021 gaactttggg agcaagtggg gagaaatctt aaacaacacc aggcacaaag gcatcaggtc 22081 ccagtaaaat cttttatgtt aggggctttg agtagagcag ccctggttgt tacacacaaa 22141 agagcctaaa aagggaaagg aggaggaaat gtcacctgcc ttatcacctc cccttccctc 22201 agtgccaata tcactgggcc aaaataacaa agaggaaatg gaggtcttac ctaagcttcc 22261 tcctccaata gataggaaga aggacagagg atacgctaca gctatcagtc cctgtcttaa 22321 gcaggcagca ttagaaggag agctcttagc cgggtgcagt ggctcatgcc tataatccca 22381 gcactttggg aggccgaggc aggcagatca tgaggtcagg agatccagac catcctagct 22441 aacatggtga aaccccgtct ccactaaaaa tacaaaaaat tagccaggca tgttggtggg 22501 cacctgtagc cccagctact tgggaggctg aggcaggaga atggcatgaa cccaggaggt 22561 ggagcttgga gctttcagtg acctgagatt gcaccactgc actacagcct gggcaacaga 22621 gcaagactcc atctaaaaaa agaagaagaa ggagagctct taacctgctc agtaatgcaa 22681 aatcggcaag gcaatcaggt gtatgtttat aaaaagataa gaaaaaggca ttagaagcca EPI-109 1145

22741 aaaccacgtg gccaagcagg cagtgggcag gagaaaatgc tcagaggcag aaaagctcac 22801 agcgacaaag ccaacaaggt ctgcccagga cggcagcatc cctctggcaa aggagcaagg 22861 gagcagcaca gacacaggca aagcctaaac aagtacaatg tggccacctc ccaggacctg 22921 caccactgcc ctctggctct gtgggcagcc cattgcaaaa tttcatgtgt tacatctcag 22981 gctatgattc tctgctaaga tgtaagtaaa atgtaagaat ttgaaaagca tcttttctaa 23041 taatggccac tattgtcatc tctctcctat ccctgatgta gctttccaaa ttcaatttaa 23101 gtaaaacagt aacctttgaa gggaaagaga ttacagaggg cccatgaatt agttgaagag 23161 taattaaaag ctaggcatgt aaaaccacac attacgcttt aaagaagaaa tttaaaccta 23221 attaaatgat atttgttaaa ttagaaggta aaaatgttgt gccctgttgg gaacaggccc 23281 ccaaatctgg ccataaactg gccccaaaac aggccataaa caaaatctct gcagcaccat 23341 gacatgtttg tgatggccat gatgcccacc ttgaaggttg ttggtttact ggaatgaggg 23401 caaggaacac ctggcccacc cagggcagaa aattccttaa aggcattccc aaaccactaa 23461 tgatagcatg agcaatctgt gccttaagga catgttcctg ctgcagacag ctagccagag 23521 cccatccctt tgttttggcc catccctttg tttcccataa ggaatgcttt cagttaatct 23581 atgatctata gaaacgatgc ttatcactgg cttgctgtca ataaatatgg gagtaaaact 23641 ctgttcaggg ctttcagctc agaaagccat aagccccctg atttcccact tcccaccctt 23701 tatttctgtg tgtgtgtctt gaattcctct agcgcctctg ggttatggtc tccacaacca 23761 cgctggtctt ggcagtgccc ttctcagaaa gtgaaaaaga gttgtatgta agtgtagtga 23821 aaacataagc atgaatcact gtcttaaccc actgattaga tagtctttga tttgtacttg 23881 ctaaaagagt cctaaattga gttcctcagc tagtgagtca ctgttttcaa gactgtttgc 23941 cagattgaag tccataaact tggtcagccc gaaaactcaa ttacaagatc taagctattc 24001 tgcctgtggc tttaagcaca tggttaaagt atattattta agtctctcct tctagatatg 24061 ctttcagatt ttctttttaa acttcttgtt acttatttca gctttccata ttgataatta 24121 atgcagtcaa ttgctcagtt atgactgtga tatcatcagg attcctttaa gtaaaaggca 24181 attcaaagcg gtattgcact cccccatacc taatgcttta acactgttta ctgatgggtc 24241 tggtaaacat ggaaaagctg cagtctagta gagaccacat aattcaatca ctcgatctga 24301 gttcactagc actcagagag ctaaggttac tctgtttatt tattaaagaa tttttacaac 24361 cttaagctca ctctggactt tccagcctta tgtggcaaat gtagccatca atttatgggg 24421 tcaagactta cttacagcat gggatatgag gcttacaaat gagactttga taacccagga 24481 ttttaaatgt tgaagaacac gggatatcag agtgaaaaag gtttagggaa aattctgaca 24541 agggaaaatt ctaacctgat atcaataact ggaaagacag gttaaaccct gcaaggggat 24601 acattgacat tttttcttcc tcacttgctc ttttctgctg tctgaatatg ggcatgaggg 24661 caagagtcat tttagaccac caagtgacct tgaggataga agccttatac tagaggtggt 24721 gggaaagaaa aaacagaagg actcataaag aaaaaaataa taaacctcag tattaagatg 24781 gaaaaattcc cccaattggt ctataggttg aacttcatct ctattaaatt tcagctatgt 24841 ttttgcagaa tttgatatgc tgatcataaa atttatatga aaatgcaaga gacacagaat 24901 agtcaaaact ttgaaaagaa gaaagttgga ggacttacac ttgttgattt taaggctttt 24961 tacaaagcta taataatcaa gacaatgtgt tactgacata atgatagaca tattgatcaa 25021 tatagacaat ggatgaatgg agtagaattg acagtctaga aataaaacct tatatatatg 25081 gtcaatttat ttctttatgt attctgtcat ccagaataca taaagaacac cttcaactca 25141 ataacaacaa taccaacaag ggtgccaaga ccaatcaatg gaggaaataa tagtcttttc 25201 aagaaatttt gctgagacaa ctaagtattt atatgcaaaa taatgagttt gaatggctac 25261 catatacaaa aattaactca aatggactat attaggtcag tgcaacagta attgcagttt 25321 accaccatta cttgtttttt ttttttggtt tttttttttg agacagagtc ttgctctgtc 25381 acccagacca gagtgcagtg gcatgatctc agctcactgc aagctccact tcctgagttc 25441 acgccattct ccttcctcag cctcctgagt agctgggact acaggcatct gggtaatttt 25501 tttgtatttt tagtggagat ggagtttcac catgttagcc aggatggtct caatctcttg 25561 acctcgtgat ctgcccacct cagcctccca aagtgctggg attacaggca tgagccacca 25621 cgcctggcct accattactt ttaatggcaa aaatgcagtt acttttgcac caccctaata 25681 gaactaaatg taagagctaa aactacaaaa ctgttagaag aaagcatagg agcaaatctt 25741 aatgacatga gagttggcaa ttgtttttta gatatgacac caaaagcatc aaggacaaaa 25801 gaaaaaaatg gataaattgg acttcctcca aattaagaga acttttgtcc tgcaagcaat 25861 actattaaga aagtgaaaag acaagtcaca aaatgggaga acatttttgc acataatata 25921 tttaataata ggctgacatc cagaatacat aaatacctac aactcaatac caaaaagaca 25981 gcccaattta aaaatgggcc aaggatatga ataaacattt ctctaaagaa gatacaaaaa 26041 tggtcaatat gcacatgaaa agatgctcaa tatcaatatc tattaggaaa atacaaatta 26101 aaacacaaaa tataaaacac aagatatcaa tttacactca ccaggatggc tgttatcaaa 26161 aagacagata acaagtattg gcaaggattt ggggaaattg taaccttcat acattgctgg 26221 taggaatata aaatttgcag caggtttgga aaacagttta gcagtttctc aaaaagcctg 26281 ggcatggtgg ctcatgccta caatcccagt gctttaggga gctgaggtga gaggattgct 26341 tgagcccagg agttggagac cagcctgagt aacacagtga gacctctttt ctaccaaaaa 26401 gaagagagtt aaacataggg taccatataa gccagcaatc catctcctag atatgtaccc 26461 aagaaagttg aaaacatata ctgacacaaa aacttacata tgaatcttca tattagcctt 26521 ataataatag ccaaaaagta gaaacaaccc aaatacccat caactaatta aaatatggtg 26581 tatctataca tattatttgg ccataaaagg aagtactgat acatgtcata acacaaatga 26641 accttggaag cactatgatc tctgtattag tcagctcttg tattgctata aagaactacc 26701 tgagactggg taacttataa agaaaaaggc ttaattgagt cacagttcca caggctgcac 26761 agggatcatg gcccaggaga cctcaggaaa cacagttatg atggaaggaa gagagtgaag 26821 gaggaggtgc tacatacttt taaaccacca gatcttgtga gaagtcactc actatcatga 26881 gaacagcaag ggagaagtcc acccccatga tccagtcagc cccagccagg ccccaactcc 26941 aatattgggg attacaattc cacatgagat ttgggtgggg acactaatcc aaacaatatc 27001 attctgcccc agcccctccc aaatcctgtg tccttctcac attggaagat acaatcatcc 27061 cttctcaaca gtttcatttc agtattaact caaaaatcca aagtctcatc tgagacaaga 27121 caagtccctt ccacctatga gcctataaga tcaaaaagaa gttagttact tccaagatac 27181 aatggaggta caggcattgg gcaaatatat ccattccaaa agggaaaaat tagccaaaac EPI-109 1 146

27241 aaaggggcca caggccccac gcaagtccaa aatcaagcag ggaaatcatt aaatcttaaa

27301 gcttcaaaat gatatccttt gactccatgt ctcacatcca ggccacacca atgcaaggag

27361 tgtgctccca aggccttggg cagctctacc ctgttgctct acagggtata gcccccatgg

27421 ctgctttcac aggctggcat tgagtgcctc cagcttttcc aggtacacag tgcaagctgt

27481 tagtggatct accattctag ggtctggaag attgtggccc tcttctcata gctccagtag

27541 acagtgcccc agtggggaat ctgtatgggg gctgcaaccc cacatttctc ctctgcactg

27601 cccaatagag gttctccatg agggctccat tcctgtagca tacttctacc tggacatcca

27661 ggtgttttca tacatcctct aaaatctagg taggggctcc caagccttaa ctcttgccct

27721 ctgcacatcc gcaggcttaa taccacatgg aaaccaccaa tgcttatggc ttgcacccta

27781 tgaagcagta gtctgagaca tatctgggcc cttttggcca tggctgggat gcagggaaca

27841 gtgtcctgaa gtggcacagg gcagcggggc catgggcctg gcccatgaaa ccttctttcc

27901 tcctaggcct ccagacctgt gatgggaggg tctgcctcga cggtctctag aatgtgtttg

27961 aggcatattc ctcattgtct tggctattaa tatttggctc ctctttactt atgcaaattt

28021 ctacagcctg attaattcct ttccaaaaaa atggggtttt cttttctact acatggtcag

28081 gtcacaaatt ttccaaactt ttacgcttcc ctttgaaatg taagttccag ttgcaggtca

28141 tttctttgat cacaaatata agcatatatt tgtagaatca gccaggccac atcttgaatg

28201 ttttgctgct tagaaactgc ttccaccaga taccctaaat cattgctatc aggttcaaaa

28261 ttctacatat ctctagggca agggcacaat gcctccaaga cctttgctaa tgcataagaa

28321 aattgacctt tgctccagtt cccaataagt tccccatctt catctgaggt ctccttagcc

28381 tggacttcat tgtccatatc agtatcagca ttttcatcac aataatttaa ctagtctcta

28441 agaagttcca aactttccct tatcttccta tcttcttctg agccctccaa actgctccaa

28501 cctctgccca ttacccgggt tccaaagctg cttccacatt ttcggtatct ttatagcaat

28561 gctccattcc tgataccaat tttctgtatt agtctcttct cgcactcctg taaagaacta

28621 cctgagactg ggtaatttat aaagaaaaga ggtttaattg actcacagtt ccacaagctg

28681 tataggaagc atggttcaga aggccacagg aaacttacaa tcatggagga aggcgaagag

28741 aaagaaggca cgtcttacgt ggctggagta ggaggaagag agtgaagggg gaggtgttac

28801 acacttttaa acaaccagat cttgtgagaa ctcactcact atcatgagaa cagcaaggga

28861 gaggtctgcc tccatgatcc aatcacctcc taccaggctc ctcctccaac attggggatt

28921 atgatttgac atgagatttg ggtagggaca caactccaaa ccatatcaat cccatttata

28981 tgaaatgtcc acaatagata aatctataga gacataaaat agattggtgc ttgcctagtg

29041 ctggacgtga caggagggtg tgagtaaaag aggcaatgga gtgataggta cagggtttct

29101 ttttggggtg atgaaaatat tataaaatta gattgtggtt atagttgtat aactcttgaa

29161 tatcctaaaa atatattgaa ttttccattt ccattttaaa tgggtgaatc ttatggtatg

29221 tgaattatat ctcaataaaa ctgcaaaaaa tgcacaattt gcaattgcaa aaatatggaa

29281 ccagtccaaa tgcccatcaa tgagtggata aaggaactgt ggtatatata tatatatata

29341 tatatatata tatatatata tatatatata tatatataca cacacacaca caccatggaa

29401 tactactcag ccataaaagg gaataaaaca atggcattct cagcaacctg gatggaattg

29461 gagaccatta ttctaagtga aataactcag taatggaaaa ccgaatatca tacattctca

29521 ctcataagtg ggagctaagc tatgaggatg caaaggcata agaatgatat aatggacttt

29581 gggaactcag ggaaagggtg agagaggggt gaggaataaa aggctaccca ttgggtacag

29641 tgtacactgt tcaagtgatg gctgcaccaa aatctcagaa atcaccacta aagaacttat

29701 ttacataacc aaataccacc tgtttctcaa aaacctattg aaattaatta atttttaaaa

29761 actgctgaaa tcaatagtga aaggatggac tattcaataa tgacacagtt aattgaatat

29821 catattttaa aaattagatc cttacctcac actataacat aacaataaat tccaggtgaa

29881 ttatagacca aatatgaaaa gcaaaatttt aatattttag aagacaattt ttatgacctt

29941 aagttagaaa atgattttta aaaacaggat gcaaaaacac taatcataaa gagatatttt

30001 aggccaagca tggtggctca cacctgtaat cctagtactt tgggaagctg aggcaggtgg

30061 atcacttgag gtcaggagtt caagacaagc ctggccaata gggtgaaaca tgtctctact

30121 aaaaatacaa aaattagctg gaaatcgctc gaacccagga ggcagaggtt gcagtgagct

30181 gagattgtgc cactgcactc cagcctgggt gacagagaga gactccacct caaaaaaata

30241 aataaataaa aataaagaga gattttaata aggtgcatta aaataaaaaa ctatccatca

30301 aagacaccat gaataaagtt aaaataggcc acaatgagaa tatatttgcc atgaattttt

30361 tctttttttt tgagatggag tcttgctctg tcacccaggc tggagtgcag tggtgcaatc

30421 tcggcttact gcaaacttca cctcccaggt tcaagcaatt ctcctgcctc agcctcctga

30481 gtagctggga ttacaggtgt gtgccaccat gcctggctaa tttttgtatt ttttgtagac

30541 acggggtttc accatgttgg tcaggctgag ctcaaacccc tgacctcgtg atccaccttc

30601 ctcagcctcc caaagtgctg ggattacagg catgagccac cgtgcctggc ctaccatgaa

30661 tattttttta aaggtagcat ccagaattaa taatcttctc caacaaattt cattagtagt

30721 cagggaactg caaattaaaa tcaaagtaaa atactacttt ccactcatta gactaaaatc

30781 cattcaagtc tgataatacc tagtactgag ttggagtaat agaaactgct aatgggacag

30841 ttagttggtc atcactttgg agagaaatta gtcagtatct agtaaaagtt agtgatacac

30901 cttccatttt catctgttct gtgctgctac caaagaatac ctgagactag gtaatttata

30961 aataatagaa atgtatttct aatggttcta gaggctgaga agtccaagat tgaagggcca

31021 gcctctgcag agagccttct tgctgtgtca tgccatggca gaagggcaaa gagagggcaa

31081 gagagagcaa aagcaaattc acagcatcaa tcccttttat aatcagcatt actctattaa

31141 tgagggcaag accctcatgg cctaatcacc tctaaaaggt cacacctctt aatactattg

31201 caatggtaat taagtttcta atacatactt tttgggagac attttcaaac tatagcacct

31261 accctatagc ccaacatttc tactcctagg agtatgccct agagaaattc tgcataaata

31321 tctaaagaga ggccattgtt gcattgttag gtactggaaa attggaatca attactatgt

31381 ctaccagcag cagaagatgg ctttttaaaa gttttggttt attcatgaaa tggaatattg

31441 cataaagtat gctccatctc accagatgaa aacatttttc actaggacta tttcaaaagt

31501 agtcttatca ctgggcttct ctattatgca taaaaatttt aagtgaacat gttctttgac

31561 ctagtactcc tacttttagg aatttgccca aaagggacaa ttatactact gggataaatc

31621 tttgaatcat aaagtaagtt gtaaatggta caagcagtat gtcttatttt tatttaaagc

31681 acattaacaa tattacacat atagtaaaaa ataaataaat aaaacatgtg aataataaac EPI-109 1 147

31741 acccaattta gaacaagtgt tgacagtgga gagggaaaga gagagaaaga aggagaaatg

31801 gggagtggga gcgggtacac aaggaaattt tagttgcagc tccaaatttt tactttttac

31861 acaatgaagc gaatatggca aaataagatt tgttaaagtt gggcagcagg tacacagata

31921 ttctatcatt atcctttgaa tatttctgta gatttaagtt gtccattaaa aaaataaaat

31981 acacacataa tttttaagat tagttttttc tatttcctgg ccttcgcatg cactgttaac

32041 tttacctgga attctttatg cagtaattaa gagcaaaggt gtagagcaag actgcttgag

32101 cttggatccc agcactgagt tgatttaggg agaataactt aatctcttaa tcccaagaga

32161 aaatatgata taatagtttt gagctcataa agttttcata agcattaaat gtgacctata

32221 tatgtaaagc aatctaacag tgcctatagt atttataagt gtctgcatta ccaaattcat

32281 cattatcatg gcatgtcatg tcaccatcca ctacattacc atcactgtca ccatcatcat

32341 catcaccacc accatcatca ttaactccct ttgtctagtc aattcatatt tgttcttcgt

32401 attttagata cctgttaaaa tattttttca aagatgtcta ctctgattct tcagtacaaa

32461 tttgatttaa taagatccta tcattttgtc caaatactta taaaaatttg tagttctata

32521 tttaatgtgt tttgtttgtt taacatctct ctcctacatt gtgttaagtt ttttaaagag

32581 aaggtaaggg ttaaagagag acatagagag agaaagagag acagagagag agagagagcg

32641 gttctacagc aatacaggta tattagaaaa acctgcaaag gtggggacca gcttaatgcc

32701 agagcccccc actgcttata ggctggggta cttataggtc tgggggtact tataggcctg

32761 ggtgggtggg gtctgagcag tatggcttgc tgcccaagaa gatgttgata agacgttccc

32821 atgatgaggc agtttggtcc ttgcttccat agagtgtgat gcttcttgca ctttttccca

32881 gcagaatgtg gtagggatgt tccttcaggt gggcctttgc ctggcagggt atgataagga

32941 tgttcctgtg ccttggaatc aggtagttag acaggatgtt tctcacagcc tgaaccccca

33001 tggaatgttt cactttgacc agggtctgcg aaatagcagg gggcttacaa aatggtgtag

33061 tttggactaa caccttggaa cacaaaagtt tcttggggcc aaggctggcg tattagtctg

33121 ttttcatgct gctagtaaag acatacctga gactgggtaa tttataaaga gaaaagaggt

33181 ttaatggact cacaattcca catggctgga ggcctcacaa tcatgaggga ggcaaaggag

33241 gagcaaaggc acgtcttaca tggtggtagg caagagaacg tgtgcagggg aactgccctt

33301 tataaaacca tcagatcttg tgatacttat tcactatcaa aagaacagca cgggaaaaat

33361 ctgcctccat gattcaatta cctcccacca gattcctccc atgacatgtg gtaattatgg

33421 gaactacaat tcaagatgaa atttgggtgg ggacacagtc aaaccatatc agctgggtat

33481 gttttattca cctttttata cccattgtca tgtcttctgg acaaacaatg gatgtaaaat

33541 ggtatagact cctgagtact catttgttga atgacaaatc tatgaaccat ttgaccagta

33601 tgcagcagcc attaaaatta tgtttatgaa taatttacag catggaaaaa tttggggttg

33661 ctagtagaaa aacaaaaagg tacaaaagga tatatataat aagcctacaa tgccatataa

33721 acaatactaa cagcaaaaac aaacctataa attgggggaa gatggggcag atagaagtaa

33781 cctaaaatac taacatgttg ttttggggtc atgaaattat aaatgattat gcacccctta

33841 atttttactt tctatgtttg atttttctat ggtaaatgca tttttattga ggtggaattc

33901 acataacatg aaatgaaaaa tttagtggca tttattatat tcacaatatt gtacaaccac

33961 tagctctact tccaaaacat tttcatcact ccaaaataaa accttgtacc cattaagcag

34021 ttactcccca ttatttcctc tcttagctcc tagcaaccac caacctgctt tctgtctcta

34081 gggatttatt tattctggat attccataaa aatggaggca caatatgtac cttttatgtc

34141 tggcttcttt caccaagcat gtttttgagg ctaatccaca ttgcagcatg tatcagtact

34201 tcatttcttt ttatgaataa ctgtatacag accacaattt gttatccatt ttttggttta

34261 tggacatttg ggttgtttcc atctctcaac tattgtgaat agtgctgcta tgtatatttg

34321 tgtacaagaa tttggttacc tattttcaat tcttttatgt atatatctaa gatgaaattg

34381 cagggttata tgctaatcct atgtttagca ttttttttta ggaaccatta aactgttttc

34441 caaatctgat gccccatttt atattcctac tagcaatgta agcaagttcc aatttctcca

34501 tatcctcaac aacacttgtt attttctatt tttgttatag ccattctaat gagtgtaaag

34561 tgatatatca ttgtggtttt ctttgcattt tccttatgaa cattgatgtt gagtaccttt

34621 tcatgtactt tttggtcatt tatatatcat ctttggagaa atgcctcttc gtgtatgttt

34681 tgcccatttt aaaactagat tgtctttgtt gttgacatgc atgcattctt taaatattct

34741 gcatactagg cccttatcag atatatgatt tgcaaatgtt ttttctcatt ttactggctg

34801 tcttttcact ttattgataa tgtcctttga tgcccaaaag ttgtttattt tgatgaagca

34861 tatttatcaa tttatttctt ttattgctca tgcttttgat gtcacctcta agaatttata

34921 accaaatcag aggtaatgaa ggtttacccc tctattttct tctaagagtt ttatagtttt

34981 gactcattta cttaggtcgc tgattcattt ttagttaatt tttgcatatg atgtgaggaa

35041 gaggtccaac tttactcatt tgcatgtgga tattcagctg tgccagcacc atttgtgaag

35101 agtctatcat ctcctcattt aataatagta ttgacacctt tgttgaaagt caattgataa

35161 taaatgtatg agtttatttc tggaatctaa attctattcc attgatctac atgtctatcc

35221 ttgtatcagt atcacactat cttgattact gtagatttgt agtaagtttt gaaactagaa

35281 agtgtgagta ctgcaatatt cttctttttc ttttttaaag attgtcaggg cctcttgcaa

35341 tttaataggg atatgaggat tgacttttct attctacaaa attaaaattt tgttagagat

35401 tgcattgaca ctgtaggtag ctttcagtaa cattgccatc tcaacaattt taagtattct

35461 aatacatgaa tatgagcttt ctttctcttt atttaggtct tctttaattt ctttcagcag

35521 tgttttgtag ttttggggta caagtctttc acctttaaat tttggtgaaa tttattccta

35581 ggtattgcat ttttttatgc tattgtaaat aaaattattt tctcaatttc ctgttggatg

35641 ttcattgcag gtgtatagaa actcaactga ttctttgtgt tgatcttatg ctgagaccag

35701 ctcagttggg gagaccctaa cctagaagca ctagaggaat taaagacaca aacacagaaa

35761 tatagaggtg taaagtggga aatcaggcgt ctcacagcct tcagagctga gagcttcaaa

35821 cagagattta cccacatatt tattaacagc aagccagtca ttagcattgt ttctatagat

35881 attagattaa ctaaaagtat cccttatggg aaacgaaggg aagggctgaa ataaagggat

35941 gggttgggct agttatctgc agcaggagca tgtccttaag tcatagatca ctcatgctat

36001 tgtttgtggt ttaagaatgc ctttaagcgg ttttctgccc tgtgtgggac aggtgttcct

36061 tgccctcatt ccggtaagcc cacaaccttc cagcgtgggc attatggcca tcatgaacat

36121 gtcacggtgc tgcagcggtt tttatggcca gttttggggc cagtttatgg ccagattttg

36181 gggggcctgt tcccaacaat cttatacctt gcaattttgc tgaatttgct tgttaacttt EPI-109 1148

36241 gatagttttt ttgaggatta tttgggattt tctacatatc atgtcatctc tgaataaaga 36301 tagttttgct tctttctttc tcatttggat gccttttatt tccttttctt gcctaatttc 36361 cctggctaga acttccagta tgatgttgaa taaccatggt gaaatgggca ttcttgtctt 36421 tttcctgatg ttagagagaa atttttcagt ctttaaccat tgagtataat gttagctgtg 36481 ggttttttac aaatatcttt tatcatgttg aggaagttcc ttcctactcc tacttcttgg 36541 agtgtttttg atataaaggg tatttaattt gtcaaatgct ttttctgtgt cagttgagat 36601 tatcatgtga gatttttttt ccttcattct attagtgttg atgttacatt ggttgatttt 36661 ttatgttgta ctacatttgc attctttata taaatttcac ttggtcatgg tgtataaccc 36721 ttttaatatg ccattggatt tagtttgcta gtattttgtt tagagttttt gcatctatat 36781 tcataagcaa tatcagtcca caggtttttt gtggtttatt tgtctggctt tgctataatg 36841 gtaatgctgt cttcttagaa tgaatgaggg agtgttttct cctctttcat tttttaaacg 36901 tttgagaagg agtgatatta atttttcttt aaatgtttgg tagaacttac cagtgaagcc 36961 gtctggttct taacattttt ctgtgttggg aggtttctga ttaccaattt gatctcttta 37021 atttttacag atcttttcag attttctatt tcttcttgag taacttttta gcaatttatg 37081 tattttagaa atttgttcat ttaatctagg ttatttaatt tattggtgtg cattttttca 37141 tagtattatc ttataatctt ttaatttttg taaagttgat aatgtcccca ccttacctga 37201 tcttagttat ttgtgtcttc tctgtattct ttttgtcttc ttcttctgtc ttagcatagc 37261 taaaggtttg tcaactttgt tgatctttta aagagtcaac ttttgctttc agcatgcatt 37321 actttttaaa tagaaatata tacacctaag ttgcattaca aaggagttgt cctccacaca 37381 cttattcttt cccaccatca gaggtttatg gtccccgcaa aagtcaccat cagttgggct 37441 caactccaat cagtcatggt aggtcagggt ccatctcatt gtctccatca ctcatgccca 37501 cccagggtaa gtctaatcat gttcaccaat cagaacctct gccacatcag ctctgtgggt 37561 ttcctctcat gccatctgta ccaacaatga gcacagtctg ggtttcctga tgttttctat 37621 agcatggtgc ccctccctgg gacacctcag aagccacaat gatattcatt aaacttcttc 37681 ctgcaagtac tccctctatt gctccttcta ctcaccaagc ttagtgtcag ggaatatgct 37741 ggtggggagt atgaatctta gcttctcact cccagactcg gctcccaacc tgctgttgcc 37801 aagtcttggg gacatctata aatgccttct aaatacctgt cttggcctat ccccagccac 37861 agattcctcc ctagagcagg ctacctctga ggcatctata ctgagatctt aatcacagag 37921 acatttaaaa catctaggct acaaaagaat tcctactata gggttcaaat gaatttcttt 37981 ccgtcacttg agacagcttt ttagcaagta catgtattaa agattctgat ttcccctttt 38041 ttctcctaca gtttgtttgg cctaaaggta tgacatctaa tctgctgcat ttacactcta 38101 agtcaaaatt accattttgt tcttttaatt tctatttcta atcatacatt cttgtctact 38161 cctggttcat ctggagacaa agttgaactt agaagatgga ggagaaattc ttatctgccc 38221 tctgctagtt gacacttcct ttccaagaat catttgcagt tgctgggctt tcttgctgtg 38281 actctatgcc ctgttgtgtt actttttcat ttgtgacaaa aacagtggta atagtttgct 38341 tcatttttat tatgaagact tgaccaggat aggtaggaac ataattactg ctttttctgt 38401 gggcatcata ttggtccaga tcatgtttaa ccagaattga agatgtaaaa tcctagaact 38461 cactaatcta ttttagtagg tcacaggaag catgcaaacc ataaaaaccg caatgaacca 38521 aaagcatctg tgttgacaag aggcaagaat ttctctattt tctaaaggca ctaactgaac 38581 aaatctattg cccattactt aggaaattgc taagggcatc gttaaagtac ttcaggctgt 38641 tgaaaaacct tttctgtctt cttgccccac caccaattct ctctagctat gctttctctc 38701 acatgttctt gccatccatg gagtggcaga gaggttctga gtacaactct aactttcagt 38761 ttcaatggcc taatccccaa ctcaactgct gaccttgagt gtaaaaataa acaagatctt 38821 aaacatctta gggccagcat tctgggtctt cttttgttat ttggggagca taaactattc 38881 tcatatcatt ggcttgcaga aaaattgagc ttctcctctt ccttgcccca tgtcaccttg 38941 aggtgaccac agccctgcct tctatgtaat cctgcttggt cagcaggcac atcagagctc 39001 agtggcttgt gacatacttt ccttcaagcc tgctcgaagg gccatactca tcattgagac 39061 tgggaacctt agaaaccatg aacccagtgc caatgggtag atacagaatt ctcaaactca 39121 tgaaaaaaca tcctttttaa ctctctccgt gtgcataaag aattctaaga tgtactgatc 39181 aagattccca attttctaac tatctattaa tatatggacg aggtaagaag aaagttgcaa 39241 gaaaaaaatt tgtttgactt gacggttgtg tggttatttg ccacactccc ccagatccac 39301 tctgagtccc aggatgctga ttttaggggc tacattgcct agactgtcca ttattccctc 39361 ttcccatctg gttcagtcac tgggaagcac tggtaggagg tcagagtggg agaaggaggt 39421 taggatactt tctgcccctg ctgtcctact gctttgctga acttctagca gtggctgagc 39481 catcaacctg cagctctcaa ttccagctgt ctgtagcact caagtggtat tgtttattct 39541 tttgatcctt ctagctgtta aggaagaaaa aaataatttt ttcctcaatg ctcataagtt 39601 cttggaatgg acccctgtaa caaaagacag attaacacga gaaaagttta ttaacgtaca 39661 tattttatac gtacatagga gctatccagg gaatgaataa ttcttaaaaa ggtgactttg 39721 aattccagct catatagcat cttcaacaaa gttcagtaac attttagaga tatgacaaga 39781 caaagaaaat gaactttgag cctctaggga cagtgacttg taggaaggca aaaggaataa 39841 atggaggtaa aggctggtta gtaatacttg ttaatgaaga ttcctctggt gccatctcca 39901 ggtccacaag gatttaaatt tgtcttcagt ggtgaacctt tgttcaccct ggcagaaggt 39961 gtggaggggg gtgcagatcc gttttgtctt tgtaagtcta tatcctgctt ttagacaaat 40021 aaagggaggg aaaagagctt tccttcatct gcttcttaat tgccttcagc tcaacaatcc 40081 ttatgcaaaa gaggtacatt ttagggtgtc aaattctggt ctcccacaaa gcatagggat 40141 gacagaccac ctcaccatcc ctgttgcttc ttttaagcct gctcacccct ccaaaaatat 40201 tttcattcta tactgtctct tcaaaatctc agcggagggt gccctctgtt atcctgccct 40261 ctgtgtcagt ataagccaaa ggtttgaatc ctggctctgc aactatctac ctctgtgcct 40321 ctccttgttt atgaaattac agggctggag acaaagatca caatgtgaag acaaaattgg 40381 agagcggtcc taatcagcca gagcaaaatt tctggctctt gctcttcccc atcctgggtt 40441 gaatcatagg aacaggtggc aagatgccag ggtcaggaga ttccagaagt ggcagcaagc 40501 tcagtgttac caggtcaggg atgacctgtc ttattattga aatctcagag atatgctcca 40561 attccggccc agagacacat tgagagacaa ctggggaact tgctatgttc ctgaacaggc 40621 aatgagctgt cttccaagaa aaaacctgag acccttcaag tctcaggtct tacttagcac 40681 atataccagg tcttacacag gacacatggt tacaactgac tgaaatctgg gctgggtgta EPI-109 1149

40741 ggagctcaca cctgtaatcc cagcccttca ggaggctgag gcaggcagat tgcctgagcc

40801 caggagttcg agaccagccc gggcaacatg acaaaacccc atctctacaa aaaatagtca

40861 ggcatggtgg catgcacctg tagtctcagc tacttgggag gctgagatga gaggattgct

40921 tgaggttgag actgcagtga agcatgatca tgccaccgca ctccagccta ggcaacagag

40981 caagatcttg tcgcaaaaga aagcaaaaac acaacataac acaacaacaa caacaacaac

41041 aacaacagca aaaaagccaa cttcttgaaa tctggaaagg acacctggac tgccctgagc

41101 atttgattgt tgttggctct agcagtggat gcatccttca acctctggca ctctgcaggg

41161 ctcagactgt tctgttctgt ttgttacctg tggagtgcct gccagaccct gctctagctg

41221 ctttaggtcc atttaccctc atagaccccc agtcttgtta ttcatatttc atatttggga

41281 aatggaaact tagaaacttg ccaagtccac agcatgagat cctgcctccg gtgtctgctg

41341 gattccagaa agtgccaggg gccaacttag atgacaccat gttctctgca caatcttagg

41401 aatgctccta gtctgatgtc cccattgcaa aatttacatt atcttttaac aaaacgtctt

41461 tccaaggagg ggcatttaaa ataactgagg ttcttcttgc taaggacgtt cctgacacaa

41521 gagataattt agcatttcct tttcattaaa aagtttgaaa tcctgtaatt tgtgataatg

41581 tggatgaacc tagaggatgt taagtgaaat aagccacaca cagatagaca aataccacgt

41641 gatctcactc ttatgtggaa ttttttttta aataagttgc ttagccgggc atgatggcac

41701 acacctgtaa tcctagctac tcaggaggct gaggtgggag gatggcttga actcagaagg

41761 tggaggtagc agtgagctga gactgtgcca gtgcactccg gtctgggtga cagaatgaaa

41821 cccaatttaa aaaaaaaaaa aaagttgcta tcttagaaaa agacagtaga gcagtggtta

41881 ccagagactg gggaggaaag agaggaggtg agaatgggca gcagttgatc aacgggtaca

41941 aagttaccat gagataggag aaacaagtgc tggtgctctg ctccaagtag ggtgacggta

42001 gttaataatg aattctgtat atataaatag ctagaagaga gggttttcaa tatcattatt

42061 atttcaaaag aaatgataaa tgtttcagag gatggatatg taattaccct gatttgatca

42121 ttgcacaatg tatacatgta gcaaaacatc acattgtgtc ccataaatat atacaattat

42181 tatgtgaatt aaataaaaaa aaattttaaa gtcttatcta aatgaaattt ctaaccagat

42241 tctgaatcca tgataccact gaaaccagca cacatgatcg cagtaaaacc tcattatact

42301 tcctccacta tcaccaatac cctttattct ctggaacatg aaacattctg ttgtgctcat

42361 atcatgcaaa ttatcactag taggagagca gagagtggaa atgttccagg tataaagacc

42421 cacaagataa agaagctcag agtcgttaga aacaggagca gatgtacagg gtttgcctga

42481 ctcacactca aggttgcata agcaagattt caaaattaat cctattctgg agacctcaac

42541 ccaatgtaca atgttcctga ctggaaaaga agaactatat ttttctgatt ttttttttca

42601 aatctttacc attagttgcc ctgtatctcc gccttcactt tctgcaggaa actttatttc

42661 ctacttctgc atgccaagtt tctacctcta gatctgtttg gttcagttgc tgagaagcct

42721 gacataccag gactgcctga gacaagccac aagctggtga gttgtaggca ttttttccat

42781 tactttctga ttcataggct caacgcacct caaagctgga aatgccgggt ctgggtacac

42841 cctggggaac tgcaaagcct gcacacttgg gggaaatgat caagatgaga ggcaggggtg

42901 gggatggcat gtgcaccagg agatgttaga gaaaccctga ggaagagcag cgtgcagcag

42961 gtgatggggg agagtgggca gcaagcgagg ccaggacagc cactctgctc agtcaccagt

43021 ccacacaccc aggggctcac tctgcccctc tgagcaccca aggacgttaa agagctggaa

43081 ctgttagtct aaatatagga ccatccaagc tctgaaccaa aatgtgtccc ttgcctcaac

43141 tcaggagatc cacagaggca gaagtaagga atttattttc tgaaagatag atttctatca

43201 gttctgggtg acatgttctg acacttgaaa tgacacctag gacagcacat ttcaggcatc

43261 ttgctcattg ttcactgtag tagaagctac atgctagcca gttgtaaaaa tgaaattaag

43321 taatgtgtgc acagcattta acatagcatc tgagcttcag gagcactcaa ttaatgacca

43381 cagttgtgat tctttaggca gatgcatttt tttccaactt tgatcagagg tcttatttag

43441 cttctccaga tttcaagaat ctggctcagt gatatgaaat acaagacttg tgaaaagtgt

43501 caattgcaag agaaatggaa ggataaagta tacaggtggg tggaaaagaa attcacagtc

43561 actgccagaa aaaaaattct tgagaatcaa gtcctgatga tgttagggct tatagttctt

43621 attataaaga gttttatgta ctcattcagt gaacatttat tggtgcctcc tttagccagg

43681 tactatcata agagctgaaa ataaaagcat aatccagtcc ttgatcttga ggaacatgct

43741 gtgtgtagca gataacataa taagtgctta tctagatgca tgcagtgtta tgtgataaga

43801 gtaatatgac agaggataca gattaggctt cacagagaag ggggatttga gcaggaggta

43861 ttgaagggtg aatagaagct caccaatcat tttgggcaga ggggcaagga cctgcaaaac

43921 cactgaagca tgaaggaaat ggtgagttta gggaaaatga agagaagatg gctgtgactg

43981 aagcacagga tttgggattg gagaagggac tggaggtgag gctgagaaga ggcaaactca

44041 gaaaagatgt tgtgctgggc agtctggaca ttatctttga agcccaccac atataagtca

44101 tagggctact ggaggtttta agctaaaagt gactattcaa tttcaactta agagaagata

44161 ggttgagagg gaacatggct tgagatgagc catgagcaaa ggaaagacta caacaaagcc

44221 aggagtgagg agtgtgtgaa gcaagaaagt gacagttgaa agcagtgcag aggggatgaa

44281 tctgagaggc atctatgagg tggaactcaa atgacatgat aataatacag ggcatttctc

44341 tgtgtcagat gctgtcctaa gtccttactc cattgatctt cacagcaact cagcatagtt

44401 aatattttat gcataaagaa atcggcactt gaaggagtaa ttggccccag attacactgc

44461 ctataaggat tcaaatccag gtttgtttgg ctccaaaaac tggctcctaa ttttcagaag

44521 gagaagcgac ccagggcaat gcccaatttt gcttcttagg caatggagga atccacaatc

44581 ggaaggagtt ttcagcagtg ccccatttgg ggtgggttga atttgaggtc cctgcatgat

44641 acccactttg ctcacttcag tgcctaaaac tgagtatggt tcatagtagg tgttcaataa

44701 gtgttgatgc agtgaataca tgcatgggga gatatgcatc aggcaatggg aaattcaact

44761 ctaaggctta ggggaaagct ggagcttgaa gacagagctt tagaaaacag tagcatagaa

44821 gggagtagga accatgagtt tagacaatac aattcaggaa gaactttgta gcaaggataa

44881 agaggcaaaa aattaaagag gtgagagcta agtgtggtgc ctggggaatc ttaaggtgtg

44941 ggcacgggga ggagatgcca gcaaagaaca tgaataaaaa gcggtagcac agcccctccc

45001 atctggaagc caaaaagaat tgtaaatgga ggaagttagc agaaggatca aatacttgaa

45061 gagggtggaa ttggaataaa accagggcat ttgaaaaatt gggttgtcac tgcaatctta

45121 acaagagaag ttttggcagg atgatggagg cagaaagctg agagaatcat cagttagaac

45181 gtttttgact tcagagaaca gaaaatgcag ttcataatgg ctttaaaaca ggggcttgtt EPI-109 1 150

45241 tttctcccag caatttgaga ggccaaggcg ggtgcatcag gaggtcaaga gaccgagacc

45301 atcctggcca acatggtgaa tccccatctc tactaaaaat acaaaaatta gcggggcatg

45361 gtggtgcacg cctatagtcc catctactca ggaggctgag gcaggagaat cacttgaacc

45421 caggaggtgg aggttgcagt gagctgagat catggccact gcactatagc ctggagacac

45481 agcgagactc cgtctccaaa aaaaaaaaaa aagaaggcag aaggtgaata gttcaagggt

45541 gggtttagga ctcagtgata ataggattct gcctggcttc tcatggttct ctaggtcttc

45601 cattcatggc accatgccct cactaggcat gctgccagag caggaggggc aggtggaggg

45661 ttctcttgtg tctgtcttat cagggaagaa gagctttctc agaagccccc agcagactcc

45721 cttttcatat tatggtccag caatgagtca cagacctatg caccacctgc aaaggagcca

45781 gagaaaacaa acgcccagcg cttttagcct gaaaatgaga atctggtttg ctggggaaga

45841 taaagggtgt cggaaaatgg ctgttgggta aatcattgat gtctgccact aggaatgaaa

45901 ggcaaatcag gaactggcac acatgctttc agggagatgg ctgcaaggga gagggcaaag

45961 actgggaagt tgcttatgtg gtgccagact atttggaaga tcatggattg cggtgtttgt

46021 gttgtgtggt catcattttg ttctttgttt acagaacaga gaaagtggat tgaacaagga

46081 cgcatttccc cagtacatcc acaacatgct gtccacatct cgttctcggt ttatcagaaa

46141 taccaacgag agcggtgaag aagtcaccac cttttttgat tatgattacg gtgctccctg

46201 tcataaattt gacgtgaagc aaattggggc ccaactcctg cctccgctct actcgctggt

46261 gttcatcttt ggttttgtgg gcaacatgct ggtcgtcctc atcttaataa actgcaaaaa

46321 gctgaagtgc ttgactgaca tttacctgct caacctggcc atctctgatc tgctttttct

46381 tattactctc ccattgtggg ctcactctgc tgcaaatgag tgggtctttg ggaatgcaat

46441 gtgcaaatta ttcacagggc tgtatcacat cggttatttt ggcggaatct tcttcatcat

46501 cctcctgaca atcgatagat acctggctat tgtccatgct gtgtttgctt taaaagccag

46561 gacggtcacc tttggggtgg tgacaagtgt gatcacctgg ttggtggctg tgtttgcttc

46621 tgtcccagga atcatcttta ctaaatgcca gaaagaagat tctgtttatg tctgtggccc

46681 ttattttcca cgaggatgga ataatttcca cacaataatg aggaacattt tggggctggt

46741 cctgccgctg ctcatcatgg tcatctgcta ctcgggaatc ctgaaaaccc tgcttcggtg

46801 tcgaaacgag aagaagaggc atagggcagt gagagtcatc ttcaccatca tgattgttta

46861 ctttctcttc tggactccct ataacattgt cattctcctg aacaccttcc aggaattctt

46921 cggcctgagt aactgtgaaa gcaccagtca actggaccaa gccacgcagg tgacagagac

46981 tcttgggatg actcactgct gcatcaatcc catcatctat gccttcgttg gggagaagtt

47041 cagaaggtat ctctcggtgt tcttccgaaa gcacatcacc aagcgcttct gcaaacaatg

47101 tccagttttc tacagggaga cagtggatgg agtgacttca acaaacacgc cttccactgg

47161 ggagcaggaa gtctcggctg gtttataaaa cgaggagcag tttgattgtt gtttataaag

47221 ggagataaca atctgtatat aacaacaaac ttcaagggtt tgttgaacaa tagaaacctg

47281 taaagcaggt gcccaggaac ctcagggctg tgtgtactaa tacagactat gtcacccaat

47341 gcatatccaa catgtgctca gggaataatc cagaaaaact gtgggtagag actttgactc

47401 tccagaaagc tcatctcagc tcctgaaaaa tgcctcatta ccttgtgcta atcctctttt

47461 tctagtcttc ataatttctt cactcaatct ctgattctgt caatgtcttg aaatcaaggg

47521 ccagctggag gtgaagaaga gaatgtgaca ggcacagatg aatgggagtg agggatagtg

47581 gggtcagggc tgagaggaga aggagggaga catgagcatg gctgagcctg gacaaagaca

47641 aaggtgagca aagggctcac gcattcagcc aggagatgat actggtcctt agccccatct

47701 gccacgtgta tttaaccttg aagggttcac caggtcaggg agagtttggg aactgcaata

47761 acctgggagt tttggtggag tccgatgatt ctcttttgca taagtgcatg acatattttt

47821 gctttattac agtttatcta tggcacccat gcaccttaca tttgaaatct atgaaatatc

47881 atgctccatt gttcagatgc ttcttaggcc acatccccct gtctaaaaat tcagaaaatt

47941 tttgtttata aaagatgcat tatctatgat atgctaatat atgtatatgc aatatatata

48001 ggctcttgct tgatctctcc aggaggtagt gattatgaga agggggtgga gaatgatgag

48061 ttccttcacc aggagcaaag gacggggatc gtgtggaacc actgcagaac tatttccgga

48121 atcaactaag tggagagagc caggaaggct gcatcagaac ccagtaaagc ttcttgtctg

48181 gatctgagct ggtttgtttt gtgcttgctt ttccctgcct tgccactccc ctcactcttc

48241 tcttttcccc acagcctttt tcacatagct cttggctgta ggattgcccc actccaaaaa

48301 ccagtgtgtg gaggtccagg agtgagacca ggaaagaatg tgaaagtgac tacacaagga

48361 ctcctcgatg gtcgtggaaa aggaaagtca attggcagag cccctgaagc cagtcttcag

48421 gacaaagaag gagcctagag acagaaatga cagatctctg ctttggaaat cacacgtctg

48481 gcttcacaga tgtgtgattc acagtgtgaa tcttggtgtc tacgttacca ggcaggaagg

48541 ctgagaggag agagactcca gctgggttgg aaaacagtat tttccaaact accttccagt

48601 tcctcatttt tgaatacagg catagagttc agactttttt taaatagtaa aaataaaatt

48661 aaagctgaaa actgcaactt gtaaatgtgg taaagagtta gtttgagtta ctatcatgtc

48721 aaacgtgaaa atgctgtatt agtcacagag ataattctag ctttgagctt aagaattttg

48781 agcaggtggt atgtttggga gactgctgag tcaacccaat agttgttgat tggcaggagt

48841 tggaagtgtg tgatctgtgg gcacattagc ctatgtgcat gcagcatcta agtaatgatg

48901 tcgtttgaat cacagtatac gctccatcgc tgtcatctca gctggatctc cattctctca

48961 ggcttgctgc caaaagcctt ttgtgttttg ttttgtatca ttatgaagtc atgcgtttaa

49021 tcacattcga gtgtttcagt gcttcgcaga tgtccttgat gctcatattg ttccctattt

49081 tgccagtggg aactcctaaa tcaaattggc ttctaatcaa agcttttaaa ccctattggt

49141 aaagaatgga aggtggagaa gctccctgaa gtaagcaaag actttcctct tagtcgagcc

49201 aagttaagaa tgttcttatg ttgcccagtg tgtttctgat ctgatgcaag caagaaacac

49261 tgggcttcta gaaccaggca acttgggaac tagactccca agctggacta tggctctact

4g321 ttcaggccac atggctaaag aaggtttcag aaagaagtgg ggacagagca gaactttcac

49381 cttcatatat ttgtatgatc ctaatgaatg cataaaatgt taagttgatg gtgatgaaat

49441 gtaaatactg tttttaacaa ctatgatttg gaaaataaat caatgctata actatgttga

49501 taaaagattt aaaaacaact ggctgttttt ttacactgtg gtgtggaaga ttgtgttgtg

49561 ttcacaactt ttcacttctt cccctgtgtg attacacaca cctgcccttg tggtgtgact

49621 tgcagtgcgc cctacaggcc acacaacccc atgccctcca ccactggctc tgctgctgga

49681 atgtgagcag aagtgacatc tgcctcatcc aagcagagcc tcttgctcag ccacaggaag EPI-109 1151

49741 gcccattcca gatcacaccc gtcagcccgt gcgccctggt gaatgagaag acacagggag 49801 ctgcagccac atataacatg agcaagaagt ctgtgtttgc tgtgataagc cactgagttt 49861 taggggttgt ttgttaagaa gcacaaaaac cgattaagac atgtggtata tagtgacttc 49921 atatatagaa tctggaaaac tatccattta ttttcaatca tggaattcaa tatgacaagc 49981 atcccggagg gtctacctat gccagactgg gttggaaaca gaaagacaga tgttaatgcc 50041 agtgtccttt acacctccaa gtccagggcc agctgtggag tgggaggggt agagaaggtc 50101 ctgtgcacag tcacagtgcg ctgtgcagag caggaacaga ggcatctgtg aaaagtgctg 50161 agagcctgga ggacagagtg actaatgcaa tgacagtctt gcatcatagg aataacagcc 50221 acagcaggat tttattgctg ccaaagaaac tgccatttaa aaattgccag ccatccggga 50281 ggctgaggca ggagaatggc atgaatccag gaggcggagc ttgcagtgag ccgagatcgg 50341 gccactgcac tccagcctgg gcaacagagc cagactccat ctcaaaaaaa aaaaaaaatg 50401 ccagccatct ctctttctaa agtggaatcc tcaagtctcg tttattctgg ggacatttga 50461 gtaggctgtt cgagttaagc aggtggaagt tgatgatccc tcatcatcat tctgagggat 50521 gagtgtctga agactttttg gtaaggaagg gtcttggcat agcccacccc atgccacctc 50581 ccttgatctg tgatatcccc agcagctggg gaggttggag cattttgcaa agaggccccg 50641 aagcctccag aaagtaaacc ttcaagagcc catccttcct tcctcttttg tttttgctca 50701 ttatgaaaac ttccctgaca aattgaaaag gcttcaggtg agattagccc acaggaaaaa 50761 ccaccaaggg ccacccagag gggccacact gtgacagaag gagtatgggc tggtgagctg 50821 acctctggaa gacagtgcat gaattgagga gaagagattg gttccaggca tgggaggaat 50881 gaggctggaa atttcttcag acattgccac ttcggcactc tgtgtgtgtg tgtgtgtgtg 50941 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtaaacaga gtcctgtaat gcaaggtccg 51001 gccttggcag ccccagcctg gagccacagt gagatgtgag ctgagggtta tgctgggaaa 51061 aacctctccc tcccagcacc tgaaaggctc tgcaggccca gcagctcagc aagcaagggt 51121 aagggcatgg actaacatct tatttcatac tatcccttat aacacatcct aatgtaatca 51181 gctcacaata tgaaattatt tcatttctct ccagtcattg tttcaatggg gccttagggt 51241 tgactggatt ctggaggtcc ctgcctagag gagggggtgc attctgtccc tatgtcccct 51301 cctgctccat cctccacagc acgtgcctag tggtctacct tgtggggaat tcttgtacct 51361 ccctcttcta ggcatggact agcattgaga agtgggagag gagtgttagg aaaaagggca 51421 aatatagaca taccttgtct tattgtgctt tacagatatt gtttttgttg ttgttgttgt 51481 tgtttacaaa ttgaaggttt gtggcaaccc tgcctcgagc aagtctattg gtgctgtttt 51541 tccaacagca tgtgcttgtt ttacatctct gtgtcacatt ttggtaattc tcccaatatt 51601 tcaaactttg tcattatttc tatatctgtt atggtaatct gtgatcagtg atctttgatg 51661 tcactattgt agttgttttg gggcaccatg aagtgcaccc atgtaagatg gcaaacaatc 51721 aataaatgtt gtgtgtgttc tgactgctcc atggactgcc tgttcctgag acacaataat 51781 gtatatataa caattatata tatatatatt tataacaatt atatatatat atattttttt 51841 tttttttttg aggcagagtc gcactctgat tgcccaggct ggagtgcaat gatgtgattt 51901 cagctcactg caacctctgc ctccccaggc tcaggtgatt ctcccacttc agcctcccaa 51961 gctgggacta caggtgtgca ccatcacacc cggctaattt tttttttgta tttttaggag 52021 agacagggtt ttgccatgtt gcccaggctg gccttaaact cctagactca aacaatccac 52081 ctgcctcagc ttcccaaagg gctgggatta caggcatgag ccactgtgcc cagcccaaga 52141 cacaataata ttgaaattaa gccaattaat aaccctacaa tggcctctaa gtgttcaagt 52201 gaagggaaaa gtcccacgtc tctcacttta aatcaaaatc tagaaatgat taagcttagt 52261 aaggaggaca tattgaaagt caaggccaaa agctcacctc tgcaccagtt agccaaattg 52321 cgacttcaca ggaaaagttc ttgaaggata tttaagctct actccaggga acatgcaaat 52381 gaagagaaaa caaagcagcc atattgctaa tatggagaaa gtttgagtgg tctggagaaa 52441 agatccaacc agccacaaca tttccttaag tcaaagccta atccagagca agactctaac 52501 tctcttcaat gctatgaagg cggagagagg tgaggaagct gcagaagaaa agtttgaagc 52561 tagcggaggt tggtttgtga ggtttaatga aagacaacat ctccataaca taaaaatgca 52621 agatgaagca gcaagtgcaa agggagaagc tgtggcaagt tatccagaaa atctagataa 52681 gataattgat gaaagtgtct acacgaaaca acagattttc agtgtagaca aaacagtctt 52741 atgttggaag aagatgccat ccaggacttt cacagctaga gaggagatgt caaggcaagc 52801 tgcaaagctc cacaggacag gctgactctc tttttagagg tgaatgcagc tgatgacttt 52861 aagttgaagt aaatgttcat ttactatttt gtaaatcctg gtgtcattaa gaattatgcg 52921 aaatctactc tatctgtgct ccataaatgg aacaataaag cctggatgac aacacatctg 52981 tttacagcat ggtttactga atatttcaag cccactattg agaactattg ctcagaaaaa 53041 aagattcctt tcaaaatatt actgctctgc accatgtcga tcaagagctg tgttggagat 53101 gtacgagaat attcatgttg ttttcatccc tgctaacaca aacatccatt ctgcagtcca 53161 tggaccaaga ctttcaagtc ttattaagaa atatatttca taaggctatt aagaaatagc 53221 tatatatata tatatatata gccttatata gtttatatag ctaccattga tagtgattcc 53281 attgatggat ctgagcaaag caaattgaaa agcttctgga aagtagtcat tattctagat 53341 gccattagga acatttgtaa ttcatgggag gaggtcaaaa taccaacatt aacaggagtg 53401 tgaaagacat tgattccaac ccccatagat gactttcagg ggttcacgtc ttcagtggag 53461 gaagttgctg tagatgtggt ggaaacagca agagaactag aactagaagt ggagcctgaa 53521 gttgtgactg aattgccgca ctctcatgat caaacttgaa cagatgaaga gttgcttctt 53581 acatatgagc agtgaaagtg gtctcttgag atggaatctc ctcctggtga agatgctgtg 53641 aacacggtta aaatgacaac aatcgattta gaatattaca taaatttagt taataaagca 53701 gtggcagggt ttgagaggat tgactccaat tttgaaagaa gtgggtaaaa tgctatcaaa 53761 tagcatcaca tggtatggag aaatcttttg tgaagggaag agtcgaccaa ggtggcaaat 53821 tgcattgtca tcttatttta agaaattgcc acagccaccc ccagctttag caaccaccac 53881 cctgatcagt aagcagccat caacatcaaa acaagaccgc catcctcttc agcaaaaaca 53941 ctatgacttg ctgaaggctc agatgatggt tagcattttt agcaatacaa tatttttaat 54001 taaggtatgc acattggttt ttctgacata atactattgc atacttaata gactacagta 54061 taggataaac acaactttta tatgcactgg gaaaccaaaa aggttatttt tgagatattt 54121 gctttactgt ggtggtctga agctgaactc acaatctcac caaggtgtgc ctgaacctct 54181 ttagctaact ggccactgcc acagtccact ctgtgttggt caagatgccc cagagtggca EPI-109 1 152

54241 ggcacactgt gtggtcacat ccaagggcct agatatggtg ggggctccaa atggatctag 54301 atatgtgaga tctctctttg atttgacttc ttccaaccca ccattttctg ggtgctgggc 54361 tcatctcacc cagaaagtag gacccaatgt gacagttcct gcccagttcc ctcctgtggt 54421 agccacttga cccaggggca ctcttgatcc ttgcagcctc acttacacac cctatctcta 54481 cccctattaa ctctctccaa tccccactcc ccctgctcag cttgtctgct gcccagtggg 54541 ggccccaccc atgctggcct ctccttttgc aagtccccat tcctcatatg gtttcttcag 54601 agcccctttc tttggctttg aggagagatg ccctcactcg cttccccacc aatcctgccc 54661 acttctacaa tccattcatt atcctaattg cctccgtata cagactggag tgagaggagt 54721 tgatgtgatg ggtgtggata cagggctggt gctgtcatct tctagtaagc cctgggagag 54781 gtgtctgagc ccaggtgtca gtggttttct ttggaactgt gagtgcataa cacttctttg 54841 ccttcagcct taggccatag ttgctagttc tgggacaacc agaaaagccc tacataatct 54901 cgtgttatgt gcagagctga gtatagagct ccaggtatga tctgactcac ttaagatcac 54961 agtgagtcta ttgtattgtt gaactgttag cttagacatc tgttactgta cctacatggc 55021 actagcctca cgcctagaca ccgatctgaa agaaatcccc taaatgcata gagaagactt 55081 ctcagctgag ctaaggggct cccaccaggt ttgagcctat ctaatgaatc catgaggtag 55141 acagcctgca catgtccact tggtttgatg aattgcacaa atccctatgg gggatgtggt 55201 tcatgggctg ggaagtgggt taccctggga aaggtctaca ggacagaggc agggatggag 55261 acaacagcat ggtgagttcc caacccaccc acgatgatag gtgtctgagg cagaaggtaa 55321 agaggctgtc acctggtggg tgtcataaga ctcaagtgtc attgttgagg cacatgggta 55381 acaaagcgtg gcactggatg ggggtagatt cttcctattt ctgtgaggat cagggggact 55441 ccctggctct cctgctaaag gtggctctag ggacaggaag agtgtacttc ttgacaggga 55501 tgtcagagca ctgatggtga caatcagtgt gacactgctc acatgactga acaaccgaga 55561 agagcccgac tgtctactga acaacgggaa gagcccgact gtcaatgacg gagctctgtt 55621 aaatatagtt aaggctattt tgttgaatga atgaagccag acaggaaaga ggacagtatc 55681 tttaatccat ttatagaagt taaagacagg cttatttaat ctctatgaag acagagtggc 55741 ccttacctct gggtggagca aaaggcacct tctgaagtga tagggatgtt ccttatcatc 55801 ttgatccgga gtggtagtta catgcatgta tgcatatcaa aactcaccaa gctgtaccac 55861 taagtgtgtt cttcctcaat aaaaataata aagaactaca cttataaaga attttttaat 55921 aatataggaa aatgtctaca ctataatctt tagctaaaaa aaaaaaaaaa gaagccgcct 55981 acagaatggt atatgcatga gaacaattaa tcgaaaagtg catgggaaaa gtcaggattg 56041 aaacatcatg ttttaaaaga cattgttttg atactgtgag aatgtaccta agtttttcct 56101 tttttctgtt tttcccaatt ttatacaatg agcatgtgtt ggttttataa ttagacattt 56161 tgtttgtttg gtttggtttt gagacacagc ttgctgtcac ccaggttgga gtgcaatggc 56221 ccaatcttgg ttcactgcaa cctccatctc ctgggttcaa gagattctcc cacttcagcc 56281 tcctgagtag ctgggactat aggggcgcac caccacatcc agctaatttt gtgtattttt 56341 agtagagatg gggtttcacc atgctggcca ggttggtctc aaactcctga cctcaagtta 56401 tccactcgcc ttggcttccc aaagtgctgg gattataggc atgagccacc gcacttggcc 56461 tagacatttg tttttaaaaa taaaagattc atttgctctt tttacagccc gtctcactgt 56521 tgactgatat tgaccaggag tcaactcagg ccccagggat tttcacaaca gctgctgtat 56581 ggcagggttt ctgctcactg tgctcatgta gttggccctt gcacccaaag tgaataatta 56641 acattctccc catcctgttg acgatgctct gaaaatatgg tccagaaatg gtgtgagcaa 56701 ggagacagca aagcaatgct tggaacatag gtgcagtgac tagacatggg gcagctgttt 56761 aaagacaaaa aggccccaaa aaggagggat ggcacgaaac accctccaat atgggcatgg 56821 agtctagagt gacaaagtga tcaaaagttc atttcctatg gggtgtccga atgtacttaa 56881 taataaaaag agaacaagag ccatgcaaac tgagagggac aaagtagaaa gagtagcaga 56941 caccaagcaa ctaagtcaca gcatgataag ctgctagctt gttgtcatta ttgtatccag 57001 aacaacattt catttaaatg ctgaagaatt tcccatgggt ccccactttc ttgtgaatcc 57061 ttgggctgaa cccccctgtc ctgagtggtt actagaacac acctctggac cagaaacaca 57121 aaagtggagt aacacacact gcaaagctgt gcttccttgt ttcagcctgt gaatcctcac 57181 cttgtttccc atctagccta tatttttcaa actaacttgg ccatagaatc atgtagtatt 57241 tagggtggaa gctgccccag gtctagcacg tcatttaaca gatgaggaaa tggaagcttg 57301 ggcagtggaa gtatcttgcc gaggtcacac agcaagtcag cagcacagcg tgtgtgactc 57361 cgagcctgct ccgctagccc acattgccct ctgggggtga gtatgtcttc acatcctcca 57421 ataccctaat gacagacaaa cagaacatgg caaagcctca gctctgcatg gtgaaagtaa 57481 gaaccagcaa ttgccacaaa cagaaataca gtgttggtcc ggcagcctcc gggggttctg 57541 cacaagtgga ttaccagtga atacaaggct atctatcttt cgaaaaacca acgttgtatt 57601 tatgctattt tctataaaat tttatattaa tttatttgtt acctattttt gaactctttc 57661 aaaagcacac tttatatttc cctgcttaaa cagtcccccg agggtgggtg cccaaaaggc 57721 tctacacttg ttatcattcc ctctccacca caggcatatt gagtaagttt gtatttgggt 57781 ttttttaaaa cctccactct acagttaaga aaactaaggc acagagcttc aataatttgg 57841 tcagagccaa gtagcagtaa tgaagctgga ggttaaaccc agcagcatga ctgcagttct 57901 taatcaatgc cttttgaatt gcacatatgg gatgaactag aacattttct cgatgattcg 57961 ctgtccttgt tatgattatg ttactgagct ctgttgtagc acagacatat gtccctatat 58021 ggggcggggt tgggggtgtc ttgatcgctg ggctatttct atactgttct ggcttttccc 58081 aagcagtcat ttctttctat tctccaagca ccagcaatta gctttacctt ttcagcttct 58141 agtttgctga aactaatctg ctatagacag agactccggt gaaccaattt tattaggatt 58201 tgatcaaata aactctctct gacaaaggac tgctgaaaga gtaactaaga gtttgatgtt 58261 tactgagtgc atagtatgtg ctagatgctg gccgtggatg cctcatagaa tcctcccaac 58321 aactcatgaa atgactactg tcattcagcc caatacccag acgagaaagc tgagggtaag 58381 acaggtttca agcttggcag tctgactaca gaggccactg gcttagcccc tgggttagtc 58441 tgcctctgta ggattggggg cacgtaattt tgctgtttgg ggtctcattt gccttcttag 58501 agatcacaag ccaaagcttt ttattctaga gccaaggtca cggaagccca gagggcatct 58561 tgtggctcgg gagtagctct ctgctgtctt ctcagctctg ctgacaatac ttgagatttt 58621 cagatgtcac caaccaccaa gagagcttga tatgactgta tatagtatag tcataaagaa 58681 cctgaacttg accatatact tatgtcatgt ggaaaatttc tcatagcttc agatagatta EPI-109 1153

58741 tatctggagt gaagaatcct gccacctatg tatctggcat agtgtgagtc ctcataaatg 58801 cttactggtt tgaagggcaa caaaatagtg aacagagtga aaatccccac taagatcctg 58861 ggtccagaaa aagatgggaa acctgtttag ctcacccgtg agcccatagt taaaactctt 58921 tagacaacag gttttttccg tttacagaga acaataatat tgggtggtga gcatctgtgt 58981 gggggttggg gtgggatagg ggatacgggg agagtggaga aaaagggggc acagggttaa 59041 tgtgaagtcc aggatccccc tctacattta aagttggttt aagttggctt taattaatag 59101 caactcttaa gataatcaga attttcttaa ccttttagcc ttactgttga aaagccctgt 59161 gatcttgtac aaatcatttg cttcttggat agtaatttct tttactaaaa tgtgggcttt 59221 tgactagatg aatgtaaatg ttcttctagc tctgatatcc tttattcttt atattttcta 59281 acagattctg tgtagtggga tgagcagaga acaaaaacaa aataatccag tgagaaaagc 59341 ccgtaaataa actttcagac cagagatcta ttctctagct tattttaagc tcaacttaaa 59401 aggaagaact gttctctgat tcttttcgcc ttcaatacac ttaatgattt aactccaccc 59461 tccttcaaaa gaaacagcat ttcctacttt tatactgtct atatgattga tttgcacagc 59521 tcatctggcc agaagagctg agacatccgt tcccctacaa gaaactctcc ccggtaagta 59581 acctctcagc tgcttggcct gttagttagc ttctgagatg agtaaaagac tttacaggaa 59641 acccatagaa gacatttggc aaacaccaag tgctcataca attatcttaa aatataatct 59701 ttaagataag gaaagggtca cagtttggaa tgagtttcag acggttataa catcaaagat 59761 acaaaacatg attgtgagtg aaagacttta aagggagcaa tagtatttta ataactaaca 59821 atccttacct ctcaaaagaa agatttgcag agagatgagt cttagctgaa atcttgaaat 59881 cttatcttct gctaaggaga actaaaccct ctccagtgag atgccttctg aatatgtgcc 59941 cacaagaagt tgtgtctaag tctggttctc ttttttcttt ttcctccaga caagagggaa 60001 gcctaaaaat ggtcaaaatt aatattaaat tacaaacgcc aaataaaatt ttcctctaat 60061 atatcagttt catggcacag ttagtatata attctttatg gttcaaaatt aaaaatgagc 60121 ttttctaggg gcttctctca gctgcctagt ctaaggtgca gggagtttga gactcacagg 60181 gtttaataag agaaaattct cagctagagc agctgaactt aaatagacta ggcaagacag 60241 ctggttataa gactaaacta cccagaatgc atgacattca tctgtggtgg cagacgaaac 60301 attttttatt atattatttc ttgggtatgt atgacaactc ttaattgtgg caactcaaac 60361 tacaaacaca aacttcacag aaaatgtgag gattttacaa ttggctgttg tcatctatga 60421 ccttccctgg gacttgggca cccggccatt tcactctgac tacatcatgt caccaaacat 60481 ctgatggtct tgccttttaa ttctcttttt gaggactgag agggagggta gcatggtagt 60541 taagagtgca ggcttcccgc attcaaaatc ggttgcttac tagctgtgtg gctttgagca 60601 agttactcac cctctctgtg cttcaaggtc cttgtctgca aaatgtgaaa aatatttcct 60661 gcctcataag gttgccctaa ggattaaatg aatgaatggg tatgatgctt agaacagtga 60721 ttggcatcca gtatgtgccc tcgaggcctc ttaattatta ctggcttgct catagtgcat 60781 gttctttgtg ggctaactct agcgtcaata aaaatgttaa gactgagttg cagctgggca 60841 tggtggctca tgcctgtaat cccagcattc taggaggctg aggcaggagg atcgcttgag 60901 cccaggagtt cgagaccagc ctgggcaaca tagtgtgatc ttgtatctat aaaaataaac 60961 aaaattagct tggtgtggtg gcgcctgtag tccccagcca cttggagggg tgaggtgaga 61021 ggattgcttg agcccgggat gatccaggct gcagtgagcc atgatcgtgc cactgcactc 61081 cagcctgggc gacagagtga gaccctgtct cacaacaaca acagcaacaa aaaggctgag 61141 ctgcaccatg cttgacccag tttcttaaaa ttgttgtcaa agcttcattc actccatggt 61201 gctatagagc acaagatttt atttggtgag atggtgcttt catgaattcc cccaacagag 61261 ccaagctctc catctagtgg acagggaagc tagcagcaaa ccttcccttc actacaaaac 61321 ttcattgctt ggccaaaaag agagttaatt caatgtagac atctatgtag gcaattaaaa 61381 acctattgat gtataaaaca gtttgcattc atggagggca actaaataca ttctaggact 61441 ttataaaaga tcacttttta tttatgcaca gggtggaaca agatggatta tcaagtgtca 61501 agtccaatct atgacatcaa ttattataca tcggagccct gccaaaaaat caatgtgaag 61561 caaatcgcag cccgcctcct gcctccgctc tactcactgg tgttcatctt tggttttgtg 61621 ggcaacatgc tggtcatcct catcctgata aactgcaaaa ggctgaagag catgactgac 61681 atctacctgc tcaacctggc catctctgac ctgtttttcc ttcttactgt ccccttctgg 61741 gctcactatg ctgccgccca gtgggacttt ggaaatacaa tgtgtcaact cttgacaggg 61801 ctctatttta taggcttctt ctctggaatc ttcttcatca tcctcctgac aatcgatagg 61861 tacctggctg tcgtccatgc tgtgtttgct ttaaaagcca ggacggtcac ctttggggtg 61921 gtgacaagtg tgatcacttg ggtggtggct gtgtttgcgt ctctcccagg aatcatcttt 61981 accagatctc aaaaagaagg tcttcattac acctgcagct ctcattttcc atacagtcag 62041 tatcaattct ggaagaattt ccagacatta aagatagtca tcttggggct ggtcctgccg 62101 ctgcttgtca tggtcatctg ctactcggga atcctaaaaa ctctgcttcg gtgtcgaaat 62161 gagaagaaga ggcacagggc tgtgaggctt atcttcacca tcatgattgt ttattttctc 62221 ttctgggctc cctacaacat tgtccttctc ctgaacacct tccaggaatt ctttggcctg 62281 aataattgca gtagctctaa caggttggac caagctatgc aggtgacaga gactcttggg 62341 atgacgcact gctgcatcaa ccccatcatc tatgcctttg tcggggagaa gttcagaaac 62401 tacctcttag tcttcttcca aaagcacatt gccaaacgct tctgcaaatg ctgttctatt 62461 ttccagcaag aggctcccga gcgagcaagc tcagtttaca cccgatccac tggggagcag 62521 gaaatatctg tgggcttgtg acacggactc aagtgggctg gtgacccagt cagagttgtg 62581 cacatggctt agttttcata cacagcctgg gctgggggtg gggtgggaga ggtctttttt 62641 aaaaggaagt tactgttata gagggtctaa gattcatcca tttatttggc atctgtttaa 62701 agtagattag atcttttaag cccatcaatt atagaaagcc aaatcaaaat atgttgatga 62761 aaaatagcaa cctttttatc tccccttcac atgcatcaag ttattgacaa actctccctt 62821 cactccgaaa gttccttatg tatatttaaa agaaagcctc agagaattgc tgattcttga 62881 gtttagtgat ctgaacagaa ataccaaaat tatttcagaa atgtacaact ttttacctag 62941 tacaaggcaa catataggtt gtaaatgtgt ttaaaacagg tctttgtctt gctatgggga 63001 gaaaagacat gaatatgatt agtaaagaaa tgacactttt catgtgtgat ttcccctcca 63061 aggtatggtt aataagtttc actgacttag aaccaggcga gagacttgtg gcctgggaga 63121 gctggggaag cttcttaaat gagaaggaat ttgagttgga tcatctattg ctggcaaaga 63181 cagaagcctc actgcaagca ctgcatgggc aagcttggct gtagaaggag acagagctgg EPI-109 1154

63241 ttgggaagac atggggagga aggacaaggc tagatcatga agaaccttga cggcattgct 63301 ccgtctaagt catgagctga gcagggagat cctggttggt gttgcagaag gtttactctg 63361 tggccaaagg agggtcagga aggatgagca tttagggcaa ggagaccacc aacagccctc 63421 aggtcagggt gaggatggcc tctgctaagc tcaaggcgtg aggatgggaa ggagggaggt 63481 attcgtaagg atgggaagga gggaggtatt cgtgcagcat atgaggatgc agagtcagca 63541 gaactggggt ggatttggtt tggaagtgag ggtcagagag gagtcagaga gaatccctag 63601 tcttcaagca gattggagaa acccttgaaa agacatcaag cacagaagga ggaggaggag 63661 gtttaggtca agaagaagat ggattggtgt aaaaggatgg gtctggtttg cagagcttga 63721 acacagtctc acccagactc caggctgtct ttcactgaat gcttctgact tcatagattt 63781 ccttcccatc ccagctgaaa tactgagggg tctccaggag gagactagat ttatgaatac 63841 acgaggtatg aggtctagga acatacttca gctcacacat gagatctagg tgaggattga 63gθl ttacctagta gtcatttcat gggttgttgg gaggattcta tgaggcaacc acaggcagca 63961 tttagcacat actacacatt caataagcat caaactctta gttactcatt cagggatagc 64021 actgagcaaa gcattgagca aaggggtccc atagaggtga gggaagcctg aaaaactaag 64081 atgctgcctg cccagtgcac acaagtgtag gtatcatttt ctgcatttaa ccgtcaatag 64141 gcaaaggggg gaagggacat attcatttgg aaataagctg ccttgagcct taaaacccac 64201 aaaagtacaa tttaccagcc tccgtatttc agactgaatg ggggtggggg gggcgcctta 64261 ggtacttatt ccagatgcct tctccagaca aaccagaagc aacagaaaaa atcgtctctc 64321 cctccctttg aaatgaatat accccttagt gtttgggtat attcatttca aagggagaga 64381 gagaggtttt tttctgttct ttctcatatg attgtgcaca tacttgagac tgttttgaat 64441 ttgggggatg gctaaaacca tcatagtaca ggtaaggtga gggaatagta agtggtgaga 64501 actactcagg gaatgaaggt gtcagaataa taagaggtgc tactgacttt ctcagcctct 64561 gaatatgaac ggtgagcatt gtggctgtca gcaggaagca acgaagggaa atgtctttcc 64621 ttttgctctt aagttgtgga gagtgcaaca gtagcatagg accctaccct ctgggccaag 64681 tcaaagacat tctgacatct tagtatttgc atattcttat gtatgtgaaa gttacaaatt 64741 gcttgaaaga aaatatgcat ctaataaaaa acaccttcta aaataattca ttatattctt 64801 gctctttcag tcaagtgtac atttagagaa tagcacataa aactgccaga gcattttata 64861 agcagctgtt ttcttcctta gtgtgtgtgc atgtgtgtgt gatgtataca aagagagaga 64921 taattgtatt tttgtatttt cttttaaata atttttaaaa ttgacccttt tcctgagaca 64981 aattgccaga atagtttgta tttagagatg gtacctctaa gagtaaggtt gctggttgct 65041 gagcaattga cttgaaaact tttaaaattc aaattttaat tccactactc aaaagaattg 65101 ccatgtttta aaaaagagaa ttggtgccat aagttagttg tctatgtttg aaaatgaaga 65161 agatatgcaa cgtcatggcc tggtcactta cccgcagccc tgagttgtag gcacatcata 65221 tgtgagaatg aggatgcttt tctttcattt aaaatccctc cccaaaactt ggctctaatt 65281 gcagtcatga caatcatgta catttggatt tatgtgcacg agtctcttac cctgagagag 65341 gacaggtgct acaggtggag gggacccgtc tgggtcacgt tcacattttg aacatgctgg 65401 ttttcagtca ctgcacactc atctcccagc gcaggtcatg ggcagcagat gcaaaagctg 65461 cccgtggtcc tatttggagg tgcatgaaat gagcagaaga cagaatagct tgatctgact 65521 agaagggcag cttgtcccta ccaagacttg aaggattgcc tttcatctgt tagggtaaaa 65581 ggtagaatga accaaggaag ggcaggaggg ggctggggtt agggtagaag gaaggggcca 65641 tggagaaggg agatccatcc cataggagga aggcagtgcg gcagggaggt ttgaaggtat 65701 cagcttttgt ggctgacata catgcagtca tgtcaattgc tcgtttttcc ttttccatct 65761 tattaaatgt cttccaatgt tagcacgaag aaaagctatt tgcagtgttg ccagcctttc 65821 cagagcccgt ccccattacc tccccaggcc catgccttta ctccttggag tttcaactca 65881 cgaccttcag gatctgactt tattcaccaa ctctggggtg aacgtacctt ctgtctccac 65941 ccagaggtct ctatcaaaga ggagattgca tgccatggat aaagtcaaag tagaggtgac 66001 tgtccttagg aagagtaatg tgaaaattca taaactggga ttctgtttac attttgtact 66061 ccaggggttc ttagtttaaa tcgctctgaa taaattaaga tgcaatggca tttcaactgt 66121 tatgattaaa tttacaaatc atttattttc tatcacgggg agagatagag ctccaaatgc 66181 aaacataact gctcaagtgt taacacttat aatgaaaaca taagaattac caccaactac 66241 cctgggggct agaagcagaa atgtgaacca gaaaacaaat catgaacttt cctttttttt 66301 tttgagatgg agtctcgctc tgttgcccag gctggagtgc aatggtgcga tctcggctca 66361 ctgcaaccac tgcctcccgg gttcaagcaa ttctcctgcc tcagcctcct gagtagctgg 66421 gactacaggc atgcaccacc acgcctgggt aattttttgt atttttagta gagacagggt 66481 ttcaccgtat tagccaggat gctctcgatc tcctgacctc gtgatctgcc cgcctcggcc 66541 tcccaccgaa gtgctgggat tacaggcatg agccactgtg cccggccaac aaatcatgaa 66601 ctttctaact gcagttcctt gtagcttgtt aacacatcca cttacttatt gtcagagtac 66661 gtggagattt tccacaaccc tcggggataa ggctgaacag aagaggcaaa aacgtgaaaa 66721 catttcgata gctcctatac tttgaaataa aattcactgt aaaagttgct tgtatttttc 66781 caaaacagag tcaaccctta atatttaaga ttctgtatac aaatacatat ttttatataa 66841 ttaatatata ttgtcatatg acatatatct ttatattaat atgcatgcat ataatatata 66901 tttccttcct aattttctat aagcaatttt acaagactga cttctatttg cctccttatt 66961 gttactacgt ggtttgataa tccgttttgt gtcattgtga ttctgtcatg ttttggggac 67021 ttatttttgt ttctctgggt ggtcactagt ttttttaaag cattcatgga agagtgtgaa 67081 tcttttacaa gctaggaagc catggcaagc cttgggtcat actgcccccg cgaggccaca 67141 ttggcaaacc agcaagggtg ttcaacttcc agacttggcc atggagaaga catacgagga 67201 ggcttttcac attcagctct ttaatgtttg tctctgccgg caccatccca gttgtgaata 67261 agaggtattt ccacagcggc tcagggtagg tagtgcacag ctcacattca tcatttctga 67321 aaaccgagag gagtctccat tcggggtaca ggttgatgcc tgtcgtggaa tgaaggttcc 67381 aacacccaga ccaatctctg cagtgtgctg ctctcatgag cttgcaacaa gatcagaaaa 67441 tgttttgtga ctaagcattt ttcatattgc ataaaatgct tcaagctcct cccttgtttc 67501 tctctataat cctgtatatc tgatgattgt gggtaccaag tgtttgaaat aatcaaatgt 67561 gatttgatgt tggtaaattt cttttttttt ttttttttac ttctattttt tttattatac 67621 tttaagtttt agggtacatg tgcacattgt gcaggttagt tacatatgta tacatgtgcc 67681 atgctggtgc actgcaccca ctaactcgtc atctagcatt aggtatatct cccaatgcta EPI-109 1155

67741 tccctccccc ctccccccac cccaccacag tccccaaagt gtgatattcc ccttcctatg 67801 tccatgtgat ctcattgttc aattcccacc tatgagtgag aatatgcggt gtttggtttt 67861 ttgttcttgc gatagtttac tgagaatgat ggtttccaat ttcatccatg tccctacaaa 67921 ggacatgaac atagcaaaga cttggaacca acccaaatgt ccaacaatga tagactggat 67981 taagaaaatg tggcacatat acaccatggt aaatttcttt atcattcgca ctctcctttc 68041 tctattattg ttattgtaac tgaaccgcag attagtcact cattgcttgc agaatccaat 68101 taacaagagc gaggtcagat ataaagaaaa tgatttattc caaacctcct tcagggaaga 68161 ggtgcagcct cctgcctcta aatgcactgc ttcgccaggc gtggtggctc acacctgtaa 68221 tcccagcact ttgggagacc gaggagggca gatcacttaa ggtcaggagt tcaagaccgg 68281 cctggccaat atagtgaaac ccctgcctct actaaaaata caaaaaatta gccagacgtg 68341 gtggcgggtg cttgtaatcc cagctactcg ggaggctgag gcaggagaat cgcttgaacc 68401 tgggaggtgg aagttgcagt gagctgacat ctagccactg cactccagcc tgggtgacag 68461 agtgagactc tgtctcaaaa taaataaata aataaataaa taaataaata gtaaatgcac 68521 tgctttgctt ttggagcaga aagcaggcac tttgaaaagg caggggagga agtgagcaag 68581 ggcagggggt ctgcacactg gcatggtgcc tgatctatcc aggcagttga attggcactt 68641 tcataggcag aaataagttg aaaaagtggc ctaaaactct ctaggtggga gtggatagtg 68701 ggcatgcctt caacctgcct ttctggaggg tgagttccat ggcaaccccc tgaagggtga 68761 gagttccatg gagatcatgc tttggtctgt aaatcagctg ttaactctct agaaagttct 68821 gtcttggagc atatagttag atgaacttgc cctgtaaaga atgtctggtg aaggggaagt 68881 aaaaggtgag atttgcattt ctaaagggct aagtagaacg tggggtacaa gaggaaagga 68941 gaaaagagaa aataatttaa aaaataattg taacttattc ccttttactt agaaaaaagg 69001 gaatactcag ttacattatc acctcgttta catcaaaccc tcttatggaa tcctatggtt 69061 tgaaaacaaa aaggttgttg aggaccagtg agcccaaccc ctttgcttta taaatgaaga 69121 gcattgcctg ccctaagccc cagagactct gatgtcgtgg gtctggagtg ggctccaaca 69181 gcggcatgtt ttgatggtgc ttcccagtgg cacgccagcg atgagccttt gagtagggaa 69241 agtaggagca ctcgtgactc ccttcacgat cagcacctgt gtgctaataa attcacaaaa 69301 gccaacatat tggagtcact cagggagttt tacaaatagt gaggttaaat ccaacctcaa 69361 atagttctga ttcgatctgc ctgcattgct gccctgtggt tccccactgt agaagctccc 69421 caggtgattc taagtgtagc caagtctgag aaatactgcc taaagcctgt tggactgaca 69481 gcaagggctg ttgtctgagc aagactttgc ctggcctggg gtggcatgtg caccaggaag 69541 agtctcaact ttcataacag aacattcccc aagctggttt ttttaaagca tgtgaatcta 69601 gacttcattg gcaataccaa agatctgtat ttgaggctcc aagtatttca ctttcatttt 69661 tggttttggg ttatgttttc acccttcctt tccaagtgaa aagtaaacag aagtgggatg 69721 tctggcgccc atgctgagct tggcaacttc aaattcaata gagaagaagt ctcttgtata 69781 gaaaagggcc tgtctgagat gtttctcaaa taaatataga ttttgcttat gtggctaaag 69841 gattcttctc cccccatttc cttatccctg cagtgagcca tccttcttaa ctctttccat 69901 gaaagcatta ttcctgaaga actgggaact catgccagcc ctgatcaggc aatgataatt 69961 ctgcagagaa ttagaattta gatttaaatt gtcaactctt atacatcctg gcatatggtt 70021 taaacacatg tacacacaca caaacacctc ctactattta ctgaagagca gatatctgat 70081 aacttaatct ttttggtttt gagtcaagac aattcctcct tttgaaactg cataccgctg 70141 aatataataa aatgtaatta agattaaaaa taagaaacta atgggagaat ttcaatattg 70201 tctctgttca ctttaaaatt cctctactta ggtttactgc cattaccaaa gactattcaa 70261 aaatcctttt taggagaatc ctaatggttt cctgacatat aatcaaataa ggactctgtt 70321 gattggctaa ctcaatcttc ctgtgccaaa aagcagagcc cagcagagaa gagggcaggg 70381 acttgaaagt cagactgact cgagttccag ccttggggct gtgggagctt gggcaagtga 70441 cttaacgtct ctggctctca ggatctaaaa ggatttccag tagtaatttg gggtgttact 70501 gatacaggag ctaaaaagaa attatttagg tggttagtga gggtcagaga gtcctcggta 70561 agatttgcct tttaacaaaa agcagcccca aaatcatttg tttgctaaca aagagaagcc 70621 tgtaaaattg agctgcagac atagataagc aagctggaag cttgcacggg tgaatgccgg 70681 cagctgtgcc aataggaaaa ggctatctgg gggccaggca tgttcaacat ggattctcca 70741 tcttcccttt tctttgtcaa ccaagtgtac agtaaaggaa caggcaacat ggcacgggcc 70801 aggtagagaa cccttctgca taataaaaga ttagggtgag atggccagct tcttcccgtg 70861 ctatgtaaat ggcatacctg gtccaaccag tcttttgggc cctgtgtaaa tcagacaccg 70921 cctcctcaag ttagtctata aaaccccatg cattttaccg tgaaactggg agatccactc 70981 ggaaccccct cctgcacgag agaccttttc tcttttgcct attacacttc cgctcttaaa 71041 ctcactgctc atgtgttagc atccttgatt tccttggcat gaggcaatga accttgtgta 71101 ttaccccata caaatgatgc tgcttcatta ctaatagcaa cctgacaggg ttgtgttggg 71161 gtataaatta tctagaccag ggagatccaa tataattttt ttgtaatgac gggaatgctt 71221 tgtatctgca tcatccaaaa tggtagccac caggccaggg tgaaatgtgg ccagtgtgac 71281 tgaggaactg aatgttttcc atgatttaat ttaaatgtgg ccaatggcta ctgtaggaga 71341 cagtgtgagt ctggcatatt ataaataata aatattaata taatttgaac tttggcatca 71401 gtgtttccta gatttgaatt actatgcaag ttgcttactg tttccaagcc tcagctttct 71461 aatctgtaat tggggctaat aatagtatct gccttacagg tttgttcaga ggataaatga 71521 gaaattgcat gttgagggct taacacagtg cctggcacat aaaagctctg gtaacagtta 71581 gccactttaa taatttgcta ataatggcta tttcttcttc agattaggat gtgctccccc 71641 aaacagtgca cttagacata gcgggcaatc cagctcactc tctgcagtga gagagaagca 71701 ctggccgacc agagtcagcc aggggctcat gggtatgaaa tcaacagcat gattttgtaa 71761 gtaatggatg gaaagggcct cacaacttta tggcactgtg ttcaatttgc ttggtcttct 71821 gtagctcctt ttgaaagcct tttagggtgg attaacctgc taccaataat tctggtcaga 71881 tgtagactcc atagctcaaa gcaaactgag agagtgaggg cagcaggcca attccccacc 71941 ccttccttct ggactctgac agaagcttac actcaaggaa gagcaagtag gaattaacgt 72001 gttaagagct aggtaagcaa aacccaatga gaagttctgg caaagcccca tgggcagggg 72061 tggcttaggc acaggaaaca agtaggattt cataccacgc gcctcagtct acttccgggg 72121 ccctcatcct cagctgtgcc tatgcaaagg agagcaacca ataaacccca ccgccactct 72181 cctactgtgg aggccaggga tggccagggg taagagaggg atgggaagtg tttcctccag EPI-109 1 156

72241 ccgtcctctg agaaggagag gaaactgggc agagcttctg tcctccttca agcagaaaca

72301 gaaacaaaag aaacccctaa gggggttctt acttcccctc tagttcagtt gtgcactaac

72361 catctgcagc tcaacattca gcattcattc attgattcag caaacattga aggagggcca

72421 gctatgtgcc agatgccaac tcatgccatg aaagagagtc cctgtcctta tgaaattcac

72481 tatttagaga gaaaagcaag caaaaaggca aagtttgaaa agtactgttg aagtggcatc

72541 attgtctggg gtgaatacct gaggtttgtg gtctcacgcc aagggaatca aggactcagg

72601 cacacaagaa gtgagtttaa gagcagaggt ttaataggca aaagaaagag aaaaaagaat

72661 agctctcttg cctgcacaga gagaggggca cctgagtgga tcttcctgtt ttgtggtgaa

72721 atgcaaggca ttttatagac gagcttgagg aagtggtgtc tgatttactt aggacccgag

72781 agattggtca gaccaggtgt gatgtttaca tagcatacaa agaagctggc catcccatcc

72841 taatctttta ttacgcagac ggggtctata cctggctggt gccatgttgt ctgttcctta

72901 ctgtacacgt ggttgacaaa gaaaagggaa gatgaagaat ccatgttgaa catgcctggc

72961 ccccagatag tcttttccta ttggcacagc tgccggcatt cactcttgca agcttccaga

73021 ttgcttatct atgtctgcag cccaatttta caggttgctc tttgctagaa aagaaatgat

73081 ttgggggctg cttttcatta aaaggaaaac cttaccaagg ttaaaaagaa aaaaatttct

73141 ttttaatgcc tatgttactg tgaacagtgt cgggataagg ctctgagagc cagatgagga

73201 tgagttatcc aatccaagga tgggggtctg gaggaaaaaa tcctagagag cattgctgca

73261 gttgaataag gattagttag aagctactga gtggagcata ggagtaggaa ctcttatgca

73321 aatgtgcaga ggtgaaataa agcaaggtat agtccaggtg cctaaagtag cacagctgac

73381 ttgagataga tgatagatag gtagatagat ggatagggta catagatgat agatagatag

73441 atagatagat agatagatag atagatagat agacagacag acagacactg gtgtgagtgt

73501 gggtgtgtgt gtctggctgc gtgcatgcat tcctcctgca ggagatcagg agcagtgggc

73561 agtatggagt gacaagaaga ttgggaggta ctccttctag ccctcccctc tgctctgccc

73621 tccactggag cagaagcaaa gcatatggtg aaggggaaca aggagtctcc ccagcacagt

73681 acccgagtgc attagctatt tatcactcca cagtccccat tcacgtgtta attcagcatt

73741 tattgaatgc ttactgtttg caatgtctat gtcaagctgt caagtgtagt ttttattcta

73801 caggccacag gcacccccta actgtgttaa acaagatggt agtattgaga caggaataat

73861 aagggtggtc acaggagaat ggaagattcc aggcagcagt ttgactagta aaaaaggaaa

73921 ctgttgaaat agctgcataa tccaggggtc aataagaacc tgagaaccag ggtgtgagcc

73981 aaggctggtt aaaagcaact ggatccaata tggtgctgag tttctcctag gttttgcctg

74041 gaacctcatt atatgctcaa taacatacca aatcacacac ccaccagggc cattccattt

74101 cctggaacac tcatgtttgg tgtaaaaatg ggtggcacca cagctctgag aaatctttac

74161 ctttttcagg aaacttcatg aatattccat cctttggtta aagaaaccca taatgtagaa

74221 gccccaaacc ctactgggcg caactctctc tctcttgagt atgcctgcac ttccctttat

74281 tatttattta tttatttatt atttatttat ttatttttta gatggagtct ggctctgtca

74341 cccaggctgg agtgcagtgg cgcagtctca gctcactgca agctctgcct ccagggttca

74401 ggccattctc ctgcctcagc ctcctgagca gcagggacta caggcgccca ccacaacgcc

74461 tagctaattt tttgtatttt cagtagagat ggggtttcac catattttat tttatttttg

74521 agacagggtc tcactttgtt ggctcgctgc aacctctgcc tcccaggctc aagcaatcct

74581 ccaacctcag ccccccaagt agctgggagg acagacgtgc accaccacac ctggctaata

74641 ttttgtattt ttttttgtag agacagggtc ttgccatgtt ccccaggctg gtcttgaact

74701 cctggactca ggtgatcagc ctgcctccac cttccaaagt gctaggatta caggaatgag

74761 ccaccccacc cgaccacact cccatttctt gagtgtgtgc attttgctct gcaataaatc

74821 tctctacttt cacttttctc tgactcgtcc ttgaattcct tcttgtgaca gcgtcaacag

74881 cctggacacc aggtgcagtc aacgtctcac cagtgtttag ggacctcccc taatccactg

74941 gtatcagcat gatcagactt gctttttcag aaaaagcctt ctgtccatag accaaaggga

75001 agtgactcag agaaggggca ggaggaatca caagctccct gcctgaccag gcctggacta

75061 tggcagagac agtgagatgg tgagaaagca agggtagaca gccagccaaa tccagaatat

75121 agaaagttct acaggaaaag gtggggccaa ggtgggacag ggggaaagga attgttgcac

75181 attaacagtg caatgcagag cactggtctt gtttatgtcc aggttagaac aaaccaatga

75241 gaaagcacat ctttgagaca actggagaaa tttgaacact gactagatat aatattatgt

75301 taattatgct ttaatttggg gtacaataat gcttttgtag ctatttctaa agagtcctta

75361 tctcttaagg atacactcta aaatactagt ggattaagtt atatgatgtt tagactcttt

75421 ttaaaataat ccagtggggt gagaggcaga gggaagggag aggagcatag aggaaacagt

75481 gttggccata tgtttgtaat tgttaaaact gagtgatggg aatatggaga tttaacatat

75541 taatactatt ttctgcccat gtaatatttg aatattttca taataaaatt gagagagaga

75601 taaagaaaga aaagagaaaa gaagagaaga gagaagagat aagggaagtg gaggaaaaag

75661 agctttcttc aaggaccatt gtggtggaca caaatgaaag ataccccctt cctactatga

75721 attctaggtg tgtactaccc aagatgagtc aatcggatcc tagcttccag aaatcgtgag

75781 catgatgcag ccctacagac gcagtgccct ggaaaggaga cccatgacca tccaaggaag

75841 atgtcccatc acagaactgc cctgggtcat gtgttttcca agtccacatg tccggtagtt

75901 ccttctttcc tatgaccaat gccaccagtc ttccagcact gtcctttatt gctaggcaaa

75961 cctgagccat cctcttcttc ttgcaacttg tgcctgaagt aacatggaca caaagtcccc

76021 acttttccca cattctcaga atgaagtagt tctccctcca cactttaggt gctagaggca

76081 agtggattgc ttgagctcaa gagttcaaga ccagcctgag caacatggca aaaccccgtc

76141 tctacaaaaa atacaaaaat taactggggg tggtggtgtg cacctgcagt cccagctact

76201 caggaggcag agaaggagga tttcttgagc cctgaaggtg gttgtgttac gtgcattcat

76261 gttaagagac caccaaacag gctttgtgtg agcaattaag ctttttaatc atgtgggtgc

76321 aggcagactg agtctgaaaa aagagtcagc aaagggagat agggatgggg cggttttata

76381 ggatttgtgt aggtagtgga aaattacagt taaagggggt tgtcctcttg cgggtacagg

76441 cgggggtcac aaggtgctca gtggggagct cctgagattt attgtccagg agaaggaatg

76501 tcacaaggtc aactgatcag ttagggtggg gcaggaacaa attacaatgg tggaatgtca

76561 tcagttaagg caggaactgg gtattttcac ttctttgtgg ttcttcagtt gcttcaggcc

76621 atctggatgt ataagcgcag gtcacagggg atatgatggc ttagctcggg ctcagaggcc

76681 tgacattcct gtcttcttat attaataaga aaaacaaaac aaaatagtga tgaaatgttg EPI-109 1 157

76741 gggcagcgaa aatttttggg ggtggtatgg agagataatg ggtgatgttt ctcagggctg 76801 cttcaagcag gattaggggt gacacaggaa cctagagagt gagagagatt aaactgaaga 76861 aagattttgt ggtaaggggt gatattgtgg ggttgttaga aagagcaatt ctcatataga 76921 atgattggta atggcctgga tgcagttttg tatgaattga gaaactaaac ggaagacaca 76981 aggtctgaat aagagaagga gaaaaacagg cattaaagga ctaagaactg ggaggaccca 77041 ggacatccaa ttagagagtg cccaaggggg ttcagcataa ttatttgctt ggttggtgag 77101 tttttggtct ccatccttga gtttttttta tgttgtcata tgccaggcca gattgattta 77161 ggtaaaaaca acactcttca tttaaaaata tacagagttc tcctttctca gcagtgagta 77221 agtcaaggcc tcagcagttt tggaggaaag agaaatgcaa aggaagcaat tgtttgttaa 77281 gaaggattag aaatggctag gagagagtga gtgagattga tagtgtggtg gagatagctg 77341 aggagaggta gagggtggca taagaatggg aacgagaata agagtgagta taaaagtaaa 77401 gaatagaact tcatcagggt gaaagtattg gagggtgccc tgtcagcaaa gatcatctgt 77461 ccactccaag agggagtcaa gagtggcgga ttggggatag taccaggaga tatccactat 77521 gatggtttgg aggaaaagtg taaactggca gtgtaaacag gggcagggca tttatgagtc 77581 attgagaatg gtgaatagga gtatgactag acagaagata gtggagatga caaattttgg 77641 gggcacagtc caaatagtgg gggtgactgc gtagagctct gttgcaaaaa gtagggtaag 77701 gataaataga cttaatagaa tgaagagatg tattaggctc ataagggtta ttattgttct 77761 tcagaaatgc gagtgagttt aagggaagta ggggtgagta cttgcgactt ccagaaggaa 77821 gaggagagat caggctggct gtctgatggg cacagcttta ttctggaaca gtgaatccaa 77881 tggggagggt cgtgcagacg gatggcagtt ggggtgctat aaatgaccag gtagggtcca 77941 gtccatcaaa gctgtagagt gtgaggggtc agacttgaca aggactgatt gcccagctaa 78001 ggtatcttca catggctggg agtttggagg aggcaagaga agattagcag cctggcgaat 78061 ttcctgtcta gcctgctgga ggactggaag ataaaggcaa caggtcgtgg gcctggatcc 78121 tgtgtgagga ctctagcagc acagccttgt atttcagctg tgtgtaagga aaaaggatgg 78181 gacgagtcgg ggagtgctag tgtgggagct gtctccaggt cctttttgag agagtgaaag 78241 gaagaatggg gaaaagactt atggtctatg ggattagtta aattaccctt tgtgagctag 78301 taaagtggtt tgattaggat agcaaagccc ggtatccaaa gttggaaata tccaacaatg 78361 cctaagaagg aagggagttg ttgtttggtg gtgggggttg gggtctggga gattaactga 78421 acagagtctg caggaagggt atgtgtatgt tgatggagca ttataccaag ataggtaatg 78481 ctaggggaag aaatttgtgc ctcagagggc aatactttgt acccctttga gtaaagatgt 78541 tgaagaagca ggctagtgtc ctgctgggaa gattggtaag aggggctgca aagaagaaga 78601 tcatcaacat attgaataag gtgggaggta gatgggtgaa aagaaagcag atcatgagaa 78661 agggcctggc caaagtaatg tgggctgtcc ctgaagcctt ggggtagaaa aatccaggtg 78721 agttgttggg actggtgggt gtcagagtca gtccaagtaa ggcaaaaaga ggctgggagg 78781 agggatgcaa ggggatagta aagaaggcat ctttgaggtc gataacagaa tagagttgtg 78841 gaagggtgta ttgaagatag gagggtgtac gggtttggca ctataggatg gatgggaagg 78901 acgatttgat caacaagacg aagatcctga acaaacctgt aagacttgtc cggtttctgg 78961 acgggtagga taggggagtt gtaaggagaa tttgtaggct ttaagaggcc atgttgaaac 79021 aggcaggtga taacaggctt taaccctttt aaagcctgct gtgggatggg atattggcat 79081 tgagcggggt aagggtgatt acattttaat gggatgataa ggggtgcatg atcggttgcc 79141 aaggtaggag tagaggtttc ttatacttgt ggattaaggt ggggagatac aaggggagga 79201 tgtgaaacag gtcttgagtt gggtaaaagt gcagcaaaga gatgtggctg cagcccagga 7g261 atactcaggg aagcagataa tttggttaaa atgtctcagc ctattaagga agctggacag 7g321 gtggggataa ctaaaaaagt gcataaaaga atgttgtcca agttggcacc agagtggggg 79381 agttttaagc ggtttagaag cctcgccgac aatacccaca acagttatgg aggcaaggga 79441 aacaggccct tgaaaagaaa gtaatgtgga gtgggtagcc tccgtattga ttaagaaggg 79501 gacagactta ccctccactg taagagttac ccaaagcatc tgtgatggtc caggaggctt 79561 ctgaggtgat caggcagtgt cagtcttcag ctgctaagct gagaagatct gggaaggagt 79621 cagtcagaga gccttgggcc agagttccag gggctctggg agtggttgcc aggcaagttg 79681 aacagtctga tttccagtgg ggtctcgcac agatgggaca ttccttggcc cagtggccag 79741 atttccggca cttgaaggaa gatcctgggg gaggaggtcc tggagaaatg cctggcccct 79801 gcagtttagg tgttttgaag ttcttgtgtg ctggagatgt ggctggggtt tctcttacag 79861 cggaggcaag taattgcaac tcagaaatat gttgtcactt ggctgcctct tttctattat 79921 tgtacacctt aaggcgaggg taattaaatc ctgttgtggg gtttgagggc tggaatctaa 79g81 tttttggagc tttttctaat gtcaggagca gattgggtaa taaaatgcat attgagaata 80041 agacggcctt ctggcacctc tgggtctaga gaggtaaagt gtctaagggt tgttgccaaa 80101 caggccatgg actcagctgg gttttcatat ttgatgaaaa agagcctaaa cgctaactga 80161 tttgggagag gtcagctaaa gaaaaaggag cattaacctt gactatgcct ttagctctag 80221 ccacctctct aagaggaaat tgttgggccg gtgggggagg gctagttgtg gaacgaaact 80281 gtaagccaga ccaggtgtga ggagagaagg tgaccaaagg tttatagggt aggggagcag 80341 aggctgggga agaattggga cctggctagg cctagcgagg aacagcctgg ggaggagggg 80401 agaaatcaga tgggtccgta gaaaaggagg attcaaagga ctcagagctt ggggtggaga 80461 ctgaaggaac agacaggaga gaaagaggaa agatttggga tgagtcacat tgggagcaga 80521 gactagagag ggactgatgt gtaaagaatg cctggacgtc aggcacctca gaccatttgc 80581 ccattttacg acaaaaatta tctagatctt gtaggatgga taaatcgaaa gtgtcattct 80641 ctggccactt ggaactattg tcaagtttgt attggggcca agcagtatta cagaagaaaa 80701 taagatgttt aggtttttaa aagagtgcat aaaagaatgt tgtccaagtc catgcccttc 80761 ttaatcaata tgggagctac ccactccaca ttaccttctt ttcaagggcc tgtttccctt 80821 gcctccataa ctgttgtggg tattgatggc caggcttata agccccttaa aattacccca 80881 ctctggtgcc aacttggaga ggtcaggtgt tagtcaaagg tgttttaagt tttaagaaca 80g41 caggctaagg gagaagaagg gggaatgaag cgtggaaggt tgcccatagt gaaagaggta 81001 agtttaaaga gaaaggtaga gacatggaga aggggggagg tgagcagccc tgggctgtca 81061 tgtgggttag cagccaaagc tggtgtccca gcaattgact taccaccaag ggaatgtggg 81121 tgaatgacca aggcaggcat ccccccggtg atcagacacc aaatggaatg tgggtgaaag 81181 atcaaggtag gtgtccccat gatgatcaga caccaaagga aggctgtctt cccaaatcca EPI-109 1 158

81241 tgatccatgt tggagttttt gagttcatgg ataaaatgtg tctcctttgt ctctactaga

81301 gaggaaaaag aactggaatt tgaaggacag ggagattgaa gggtagggag agaggctgaa

81361 gaagagagtg aggagaccac ttacccggtt tgaaattggt gagatgttcc ttgggctggt

81421 ctgaggacct gaggtcgtag gtggatcttc tcatggagtg agggtgagga gaggggacca

81481 atctcccgaa ggagtcaccc tgtccggggt cttcggcacc aaatgttatg cgcatccata

81541 tgaagagacc accaaacagg ctttgtgtga gcaataaagc tttttaatca tgtgggtgca

81601 ggcagactga gtctgaaaaa ggagtcagca atgggagtta gggttggggt ggttctatag

81661 gatttgggta ggtaatggaa aattacagtt aaagggggtt gtcctcttgc aggcaagggc

81721 aggggtcaca aggtgctcgg tggggagttc ctgagactca ctgtccagaa ggaatgtcac

81781 aaggtcaatt gatcagttgg ggtggggcag gaacaaatta caatggtgga atgtcatcag

81841 ttaaggcagg agcggcctat tttcacttct tttgtggttc ttcagttgct tcaggcaatc

81901 tggatgtata tgtgcaggtc acagaggata tgatggctta gcttggactc agaggcctga

81961 caggttgctg cagtgagcca agatcacact actgcactcc tgcctgggca acagagccac

82021 aaaaaaaaaa aaaaagaaaa gaaaagaaaa aaaaagaaga agaaaaaaaa attttttttc

82081 caccaagaat ttagtaaaaa attataggga aaagtgtcac taattcaagg gaattgcact

82141 gaaaattatt cattcattca acagatattt attgagaagc aagtatgctg gtgctagggt

82201 tacaacagcg cacaaattct tgtattcaag gaatgaggta agagtatgca gataggagcc

82261 agagaggtca agaggcaatt gcaacataga gtgacacgtg ctccagaaca cataggaggg

82321 cttccaggcc ccatgctggg ctatcagagc tggcttcctg caggtggtgt ggctcagcta

82381 aaacctgaga accaagaatg agccttctga tatctcaggg ttaaatcggc acaaatgaaa

82441 ccattttata accaaacaac attttccctc ctgaactgca ctttttctag aacccattta

82501 atccttccta acatgttcaa tccagccccg tgatttttca gtcaaatgca agatgcgtag

82561 gattcctttt ctgttcagtg ctccccagcc aatctttttc ccttctccca ccccacagtt

82621 actaattcca gcgtttcagt tctcagcaga ggatgacagt tccaccagga gacatcagtg

82681 ttatctggag acattttagt tgtcccagct gagggcacag tgctgctggc atctagtggg

82741 tgaaggtcag gaatgcacct caacatcctg gaacactcag gacaatcccc agcaacaaaa

82801 acctacccat ccagaacatc aacagggctg tggctgagga gccctgctct agtgcttcct

82861 ccttactgta tcctcatcaa ggagggctct ggggcatgtc aggggctgct acaggctcct

82921 ggcagatttc ggcgacttac tccagacttg tggaacattc aggattctta gcatggccac

82981 aggagagtca ggctgtccac aagcactctc tctttcttca cccactcatt cctgtcactc

83041 taccatttcc actgccttcc caaatgccca tcgtgagtcc caccaggggc cagaacacca

83101 ctctctcaag cctccccagt ggcgcgtgca cacctggaga acatgtctca catcccccag

83161 ccagcgagac gtcctgagat tccagcactt ctcagtgtct ttcccagctt gtttgtatct

83221 ggaatggggt ggggtctctc acacaggaga aattacaagg aaaagtgtac gtgacaggaa

83281 tggaggaatt tctgtggaaa cggtgtgtga gaaaatgtag gaagaaagaa acttcaggaa

83341 atggtaagtg gcatcttgag agcagaaagt gagaagggag cagaaagaaa tggggctgga

83401 acctgggaag gagaggacag gtggggatgg ccttgcacac cgtgggcact gaggagtgtg

83461 ggcccatggc atgggtggag aggagtttca agatagggag tagattccta ttttgaactt

83521 cggattgccc ctggcgatgt ggagactgta ttggaagaag gcaagaatgg aggagagccc

83581 ctaggtggag gtttggcaat gctctctcca gaatatagca gaggcctctt ccaaggtagg

83641 aaagccctga ctggagagaa gttaatggct ctgagggctc aagggaggac ttggattatc

83701 aggactttta gggaggcata tgatcaaggc ttgggtcttg gcccattgaa atggggagca

83761 ctggttttag gatgtgggtc aattagtttg gttttcagga caggctgagt tggatatcct

83821 gggggacctc caggtggcag tgtcagggga agctggatgt gctgacactg aactcagcag

83881 agtgactgag tagagatcga catctggggt cacaggcagt ggatgccgta ggggtggact

83941 caatagctca agcagaaccc ggaggaatgc aggcagcaaa gggagcccta aagaacagtg

84001 aggagatgtg ccaagaaaga gccaaatccg ggggattggc tgtgggagag agggctgtgg

84061 gagtaagagg aagtgtcagc aacgtcaaat gttgcagaga catagagtaa ggtaagagtg

84121 gaaaaaacat ccatggaacc ctgtgatgca atcggaatgc agaaagactt tgtaactcct

84181 gcctggtctc ctcctctgcc cactcatggc aaaggaatac aaagtaatgt tccctccttc

84241 cgcctagaaa agcacaactt ctgcccccaa gccctgggct ctcctgagag gacaggacca

84301 gcctctgaag ttgaaggtcc tggttctgcc cccaagccct gggctctcct gagaggacag

84361 gaccagcctc tgaagttgaa ggtcctggtt taccagatag ggaaggggcc ctttccaaga

84421 ccctttccag aaggtgtggc tgagatggga accgtggact ctgtgcagat gtaggagctg

84481 gctccagtca agtgctagga ggttgtgggt cctgggaagg aagaggctct ggagcctctg

84541 tggagactct gggactgtcc ttgggggaga cgtgagcagg aagaagcagg gccttcacag

84601 tccccagctt aggggcctca ccacccagac tgaagaccag gaccaaaccc tttcctgcac

84661 agttacaatg tgtcatttaa ttttactaaa gggaatattt tttaaatgag gatgctactt

84721 tgtgtattaa tttttacctc tattcataaa agaaacgttt cttatctatt taagatgatt

84781 catatcagac cagtgtctgc ccaactcgac tgaccctgtg aaaactgggc acttcacact

84841 ccaatgatga tggatgagtc cccagcagca tagtttaagg gagtgagtgg gcagtgtggc

84901 ctcctgtgca cgtgacttcc tccttcagtg tgcccacatg tgggttccac ggtcttgtga

84961 cattgtggct ttagaaattt ctgtttccat tttctatcat tcagagtaaa tgaaatttgc

85021 aggaaattca gaaccttcca cctgtacagt ggatactgtg agactctgcc cagatgccct

85081 cttcaagcca atgcatctct ccatgctccc actcccatag atgggaacag aggtgctgga

85141 actcagatct actccccttt ctgggaactg gagctgcctg cccaggcaat gcccccttcc

85201 cagggatggc tgagccaatg actggctaat gttggattgc agaggcctag cgccctcccc

85261 tcaattccta attccttgta ggaataactg aggcctcctc tgtgaccacg tgggcagctt

85321 ctccctctgc ctggtcctgt cttgttctct cctttccaat tgtgtctcct ggaagccctc

85381 cccacaagtc tgctgcatac aactctcctt ctcagagagc ctgagccctg gattcccagg

85441 aatccagcct aaaatagtct ggcatttggt ttcaattttc tctttcacta agactcagtc

85501 acaggtgcta ataaataata aaatgtcacc accttgaatt ctatcactct ctcttttctt

85561 gccccatctc tgacaagtag gtggtccctc aagaacctga aaagcagaca ttaggaggaa

85621 aggaggagtg ggggcaagag gcccacacct cacctggccg gctcccatcc atgcgccctt

85681 gactgaggta acacctaccc tgggaatcct tcccctgcct ctcgtgagcc aggccgggtg EPI-109 1159

85741 ctcttgggac agctcccact gctcctgtgt gctcccccag cttggcacat gactccctga 85801 attatagtca gttccgtacc tgaatctccc tctagaatgc cagtgccacg aggacagagg 85861 acggttccac tttgttcact attttctccc cagggtctgg caaagttcct gggacttggg 85921 agaggtgtcc ttcaggagct tggcagaagc caaacggcac acttaagtag ggcaactgag 85981 gtgagtttaa tgaaggattc tatacaaaaa tttggacaag gtatagggag gccacaatac 86041 acagtgcagt gcctggtgcc agtgagagca gggcactatt cccactgcaa ggccagacag 86101 ggcaagggga gggagctgcc tgacaagagc tgcccttacg tcaagggaca catcagccca 86161 ctagacccca tcaggaggga gccagggcct gactcccctg accttgctct ccaatcttct 86221 gcctaaaatt ccccatcagc caaacacaac tgaaaactga aagacagggg agcctgctgt 86281 taataaggtg agcttccccc agaataaagc tgggtagaga gtggagaatg gatatggaag 86341 ggcaaaagga agatttataa gacagtgggc actaaatatc tatgagatga ataaaggaac 86401 cacattttac aacaaacggt cattgaaacg ctactcaatg gaaagagatc atttcggtca 86461 ctgtctggtg cagacaaatc aaagcccaca tgcatcaaaa aggccatgtc cgtgtaactc 86521 cgacacgggg cagacagcaa ggctgaagcc tatggggtat gtggagccgg aactgagaga 86581 tcctgatgta aatctagcac ttgggaaaag ggggactaga agaaattcac ccacaggcag 86641 aggaaaacac aaacacttat ctatttttgc ctaggcttta agtggtatgg gaaaaatctc 86701 tgagactaca aatcctgtgc ttcatgcaca ggtttataat accctcaaaa tggaagaccc 86761 caaaaccagg cgcggaaaat tcatatcagg ccattgatgc cctcaatgtt cccggctgaa 86821 acaaactcaa aactcctctg gaaaggagtg ctcccacttc aagccatgaa aagctactgc 86881 agagaaaata atccccagtc aagacacact cacattgaaa ctgcaaggca cacaaggaaa 86941 tggatcacct tgagtgatag ctggcagagc taataaacct ctgtatacct ctaagaagct 87001 ccacgcacta gtataaccct taaagatttg atgaaatcat tactttatta aaattgtttt 87061 tataaaaaat caaaatccaa aaaaagcaac aaattttata ccagagccaa ttcggtatat 87121 acaagggtgt cttactcttt tggaatttgt cttattgtcc taactcagca cattgtcctg 87181 gtctatgaaa agtcctagaa acccttctac cctctgtaat gtaggagctt taactcaata 87241 gggtttttta aattcttttt tcttgtcttt ttttcttttt taattttttc cattttttca 87301 agtcaaactg aagaaatatt tttcttttct ttctaggaat gcatattcac cccccaaggc 87361 cacttgtctc ctgattggag agtattagac aattctcagg atttctttat tttccttctt 87421 tattccatag gattgggaaa cccagtagga ttgggtttag gcatatctct aaagcaccat 87481 gtttcaacgt tttgatgtaa gattgtgccc tatttcttgt tcagttgctg ccagcagatg 87541 ttatagtttt aaaactagtt tttggtcatt gagatattag aggagggaag agtctgctat 87601 cctgctttac tcatcttcat ctacactaca ctgtcatctt cactgcaaag tcctgtatta 87661 atgtttttag attctataac attttaacag gtgtcaaaaa atcttaagca ccacttcagc 87721 ttgggaatct ctaaatgtaa tggtgtttgt gggctggact gatgtctgcg tcttgttgtt 87781 gttattgtct gtagtaatgg agagccggga gatcctggac acttcctgtt catgggcact 87841 tgatgcatta gctgccccag cagctgatta catttaaaca aggatgtgtg ggtgaaccca 87901 gggagaccaa tctcagtgga atggtggggg cagaagccag gctgcagggt gtagagtagg 87961 gaatgagcag tgatgaagta gaaacagagt ttggacaact agtgaaactg cctggaagag 88021 ggggagaaga gacagtaaat ggtctgacca atgtttgagg tcaaagtggg tttgtaatct 88081 ttatttaagg gacagatctg agcatttaaa aattctgaat aatctaatag agaggaaaaa 88141 gttgggactc aaagaaaatg tgggaaaaaa tgatgaaggt taaacggaat gagatccaga 88201 gtgcaggggg agagattagc ctttggtgtt agaggagcaa ctctgtccat ggagagagga 88261 aaaatgtaga cataccacag ttgcatttga agttggggcc tgaggagttg aggagttctg 88321 agaaaagcag aagatgagat catttcctga gagtaaatgg gagtcattag aacgggggtg 88381 aagagactgg aagctttagg tagcttgaaa tagttgatgg aaaaattgga taaagtgaca 88441 atttgtcaca ctcagaacag ctatcaggga atctagaaga atctctggaa gctagttgaa 88501 gatcttaaat taccaatgta tcttgtccac atagctaagc ggttttactt atttttattt 88561 ttttgaaaca gggtctcact ctgtcacaca ggctggagtg tagtagtagt agcacaatca 88621 cagctcaatg caatctctgc ctcccgggct caagcaatcc tcccacccca gcctcccggg 88681 cctgggacta cagacacaca ccaccactcc cagctatatt ttgtacattt gtagagacag 88741 ggtctcgcca tgttgcccaa gctggtcttg aactcctggg ctcaagtaat ctgcccacct 88801 cggcctccca aagtgctggg attacaagct tgagcccggc tgctaagtgg ttttaaacag 88861 ctgttctcgg aaacacacac tcaaagaaaa aatgtagagg ataatttatc taaggctggg 88921 gcttcaagag aggtcagggt gttgacaaga gaatgactaa gtggcagact actggatctc 88981 agctagataa agagggatgt gatcgtggga ggggctgata gtcagaggct ggaaggcttg 89041 atgaacaaca catattacac aaagaataaa tggagtgaga gaaaccaaag gagtaaaagt 89101 tgtcatcaga aaagtgagaa attttattgt gagaattcag tggtaaatca atgttaacaa 89161 acctcagctg ggcactagtg gagtgaaacc gaaggccagg gagttgagtt aatgagctga 89221 gacttgggca ccagatgggg gtccacatgg acaactaagc caccaggatg atgtgggaaa 89281 ctggggtgaa tagaagcccc ttatccatgt gcacaagtct tgaataaaat aggggcaacc 89341 aggcagtcag tggatgatag cagtgaggtg gagcagagag caatgtagtt ggagaagtgg 89401 agcccacagc agtctccttt atatctagaa gggaattaat agccaaaaaa tggcaccgag 89461 gccaaggatg tcaccttctg actcccaaat ctgagacaga tgtgagaggg aaggagtatc 89521 ctcaagggac aggagatggt gcgaatgttt ttggcataaa tcaaagatgt cagggaaatt 89581 gtcagaattc aggttccaga gacacagagg aaaagcgtgg gagaaagtgg aatattggga 89641 ggtgagatta gggcagagga agcacaaatc aaagaacgag gaatagaaaa agtcatatga 89701 gctgaggagt tggccaaaca tgacagaatg ggaatatgat ggaattaagt ggctttatgt 89761 gttccaaaag gattggtcca cgcaggccac aggaaaatgg gaggtaagaa gaaagggatc 89821 gaaatgctgc aaagtgtatt acttcatggt aagcaaagga ctcaagactc tagaaaatga 89881 tgcccttcct tccaagacta tgttagtcca aatctttcaa gatacagaac ccaaggtggg 89941 gtctggcata caagaagtat aatagaggaa atgtctgtga catttgcagg actgcaaagg 90001 gagccaggag aagctgggaa agccatgaga tcacaagcag gtctgactcc aagtgaagga 90061 gatggggaat gacgcaaggt ttggctgaag catgtgccaa aggcacccat cagaggagtc 90121 cctctccaag ggatgggcct atcatagtgt ccctaatagt gtcatggagt gggagcagcc 90181 cacggagggc acagccttgg catgaacgca gacatgggtc tcagagtgca gcagctgggc EPI-109 1160

90241 ccctcagtca attaggctcc ctcagagctg gggcaggagg tgcactagac cacacagtaa 90301 tatttattta ttattaattt aattaataat attaatttat taatttaatt aataatatat 90361 ttatttattt attattacta gaccacacag tagtatttgt atgtctaagg aagcatttct 90421 cagaatatac tcactgaact tttagcctat aagtacctgt atgaaaattt taaaaggggt 90481 ttcatgatca aaacattttg ggaaacactc catacccttt cttcctcatg aaggatcata 90541 atgcctatta gtatatgaag ggctctgaga agtcctgtag taaagaaact tgctttagtt 90601 ttttagtcca gcaatttttc aaacttaaat gagcaatagc ctcccatcct tttttttaca 90661 ctttttagca tactgcggaa taaactcaac atgcattgag aaagactgct ttagggaata 90721 gtcaacacta tttcactccc agtaagtaca tataaaatct gtatttccag ggtggattat 90781 caacacagct gtattttaga aatattatct gccctcccag gtatcacagc tactaattat 90841 tgggtactga ggtggaattt tagggatcag ccaattatgg gaaagaaaat ctgggggcag 90901 gataagatgg tctccgaagc cttaaaatta tatgccatta tttacctctt tgatctacta 90961 ctcaatatca aacaactaat tcagaagaaa attgattgtt ttctaaaagt agtttttcta 91021 catttcccat taagaagcag tggtatttaa aacttataat ggctattatg tgagattatc 91081 actatcatag tttttctcta tacaaatttt ctgtaacatt ttatttgcta ataaaaatta 91141 gatagatgga ttgactaatt gataatctaa gaaagattat atttgaagaa gccatagtaa 91201 gggacagatt aaattatcat cagtctaaac attctaatac ctatttctct ttttttgaaa 91261 ttttccaaat ttgttattat gcatttaaac aataattttt tgaactttta ttttaggttc 91321 tggggtacat gtgaaagctt gttacatagg taaccttttg tcatgagggt ttgttgtaca 91381 aattatttca tcactcagct atcaagccca gtactcaata ggtatctttt ctgctcctct 91441 ccctcctccc accctccagt ctcaagtaga cctcggtgtc tgttgttccc ttctttgagt 91501 tcatgtgttc tcatcattta gctcccactt ataagtgaga atacaaggta tttggttttc 91561 tgttcctgtg ttagtttgct aagggtaata gcctccagct ccattcgtgt ttccacaaaa 91621 aaacatgatc tcgttctttt catggctgca tagtattcca tggtgtatat gtaccacact 91681 ttctttatct aatctgtcat tgatgggcat ttaggtttat tccatgtctt tgctactgtg 91741 aatagtgctg caatgaacat tcacatgcgt gtgtcttcat ggtagaatga tttatattcc 91801 tctgggtgta tacccagtaa tgggatttct gtttttagct ctttgatcta atacctattt 91861 ctcaagatca agttagatct ctaaaaaagg catcatccta gcatttcccc atcccttccc 91921 tgaactaaat ttaatgttgt gtgtatcaat cagcatacag tcaagacaga aaccacacat 91981 gaacattaaa tataatgagt tattaactta taaaagggta tgaactacta aagggggtaa 92041 ggagaatgct gaagaatgca ggaatggcag atgtagagag cagccataac ctctaagcta 92101 aggcacagca gccaaggaag gggcgaactc aaaaaatgcc ctccctcccc agctgatcca 92161 cccttgttgg agggggtgtg gctgcaaccc aatggatgcc caagaagttt gcagagttgt 92221 ggcaggttgg ggctgctgag caggaaactg cccgaagggg taccagtgag attcccaaga 92281 atgtgggcat gcctctggcg aggaagacgc tcttggagtg ccagcaaaat ttactaggaa 92341 gctacccagt agggtgccag caaaagtcag caggaagcca ctgtcgtggt gtcggcaaaa 92401 ttcactgagg agtgggcact gcagggtctc cacccagcac tggcaaatca gccaaaagaa 92461 caaaaacaaa ataaaaacaa atcccagaac cagaaagaaa aaactctgcc tcttactgcg 92521 accctcttat gccttctaca gcaactggca aaggagaaat gtttatgggg tccagctcta 92581 gactcacaaa gcagaacaca gaagagtgaa tgaagagctg aaaggcgata aatcagtaac 92641 tggagcctca catcctttgc cttttttatt gagggtcaat atattaagaa gaatatgtct 92701 gcgtcttcgg taaaattatt gctaaggtta tcacccagtg tgtgttttca acctccctga 92761 tataagaact tagtgacaag aaagaatgag acaatgatca tgaactattg gacccaacca 92821 tttgtggctt tagtgcccat cttctcagca aggctttctc tctctctctc tctctctctc 92881 tctctctctc tttttttttt tttttttttt ttttaagatg gagtctcact ctgtcaccca 92941 ggccggagtg cagtggcaca atcttggctc acggcaacct ccacctcctg ggttcgagtg 93001 attctcctgc ttcagcctcc cgagtagctg ggattacggg cacccatcgc cacccctcct 93061 ggctaatttt tgtattttta gtagagatga agttttgcca tgtcggccag gctgttctca 93121 aactcctgac ctcaagtgat ccacccacct cagcctccca aagtgctggg attacaggca 93181 tgagccacca cagccagctc tcagcaaggc tttttctgac tacactattt aaaatgtgat 93241 ccctgagcca ccttggcctc tcttgctgtc cttccctgct tcgccttctc catagcactt 93301 ctctcctact aatctacaat ttacttgagc tctgtgaagg tcaggatttt tgcctatttt 93361 gtccattggt gcatccccag cacctggaac agagctaggc acaggctagg cactctagaa 93421 atacttgctg aataattgaa ttaagtaaat gagtgatcta cacgtagtgg ggaatgagag 93481 tatacagtga tagttccttc gactaaaact ggggtcaaat tatagtgata aagaggaact 93541 cagaccttca gaggtaagct ttgtggacca cttgccaagg ctgcagaatg tgatgtcgtt 93601 tcacaaacaa ggaggcccta ttatggcttc agatatgaga ataataaaga gaactttcct 93661 ttcgcctcaa ctgcagcctt ctaaactctt ccttccttcc tatgtagaag tttcaaggac 93721 ctcatggcct gagtgtggat aggcagaatg ctgggaatca ggcaaaaata aaataatact 93781 gaaagtgaag gtcatgctaa tattagtaag ccagggtgat cctgaattta caaaacattt 93841 ttctttggga aatttcacac ctcacatgat tctgtgtttt tacttgggaa atttcacatc 93901 tcacatgact ctgtgacatg cggtacatga ggtgcctgac tgctgttttt gtcctctact 93961 aatgaggaag agtgtgcgta ctcccagcgt tttgcaagtt tcaaagtctg acttgacttt 94021 ccttcctttt cctggaactg atccatgagt atcgagagta aagctgcccg cacctactca 94081 ttcaagatcc tgagtgtcct gcccagctgc aggaggtgga gagacccagg aggaggggcc 94141 actgctgatc ccaggctgta gggggtggga agagtgtccc agggcaccat gacccccact 94201 cactcactca caggagaccc acacaagaga ggagagggca cttacagctt aggttcccac 94261 cagcaccaac tcctctgcca tcaaacatca ttgtgtttct ctttctgcct tgtctgtcgg 94321 cacacgtgga gttaaattta atgctcaatc acatatttgt ctgggctctt tctgtgttta 94381 tttttctctt aatagttctc tctcctccct tcctctcccc gcccctcctc ctccttcttc 94441 tttttttttt ccagagacag tgtctcgctc tgccacccag gccagagtgc agagtggcat 94501 gatcatggct caccgcagcc tccaactcct gggctcacgt gaacatccca ccttggcctc 94561 tggaatgtct gggattacag gcacttgcca ctgcatctgg ctaattttta tattgtttat 94621 agatccggga tctcactatg ttgcccaggc tggcctcaaa ctcctgggct caagcgaccc 94681 tcccacctca tacttctgag tagctggggc tgtaggaatg cgcctcagtg ccaggctagt EPI-109 1161

94741 ttcttaattt tctatttcta ttttgacagg tacaaatttt gtattcaatc ctacctcaga 94801 cacatctttg gtgggaaaag gatgtcattt aatcaatata taaattctaa gcaaataggt 94861 ctgatcccca aattaggtta gtcacagctg ctgagtcgtt gacccaagag aagctcatct 94921 agattttttc attattttca agttcctctt ctcggttcgt ccttcttcca gaccatgccc 94981 tccccgtccc actctcttcc cacagcctcc cctccccaca gcctcctccc accattccaa 95041 atctgggctg ttctctcaat ttccttctct ctggactcaa acctacccta gcccccagcc 95101 tcagtttggg gttaaacttg tcctcctcac attctctccc acccaacttg atgtcgcctc 95161 tgtgtcatca ccacgggatt ttcctcctct gggttctcct tttccgagtg gggtcagctc 95221 ccccatgagt cacagcacca atcacttctg gctgcttgca aacccctttg ctttcctcag 95281 tgttgacacc cagggcagcc ctatgctcac tgccgctgag accccacctc tgcccctggc 95341 cttttcccag ctgacatcac cctgtggctt ccattttcct aaaattctct tttgaggcct 95401 cagtcttaac caaagcacac agtgcccctc aaaaatgaca ataaaaaccc aaacacaccg 95461 tgactgtcat ggcaggttcc tggtccccgt attgaatcag cgggtgggtt tctgcgaaca 95521 ctggtgagag gccgcattag agggtcagga ccctcaggtc tggactcgtg gtcaccacat 95581 accttcctcc ctgctgacag tagctggtac ctgttaccta ctcagagtgt cacatgccac 95641 aagccagagc gtcttggcag ttctcagcac cttgacatca cttccttgct accactcaga 95701 gcggcagtga cacagttccc ttatctcaga aggccagaag acggctgtca aaggtcacag 95761 ggaaatcaaa ggcggggtac agggccagag ggaggaggaa acaacttccc ggttgctttc 95821 agacgcttca gagatcctct ggaggcctgg gggagctttt gagtacttta tttcagttgg 95881 tccctgagct cggtgagtgg ggcgggtaga gccaccaggg gaatcaacag tggtttctcg 95941 tgcccctcag ggtcaggagc agtctgatca aaaggagggc atccactgtc cggggccatt 96001 cccacagctc ccggatgctg ggtctggagg ctgcgccctt cccctgcagg agctcagccc 96061 agtggtaagt catctgtgtg tcatctatgt atttaacccc ttatggccat gttgatgctg 96121 agcatggttt cacttttgca aacatttatt tatacccttc gagagaaaaa cgtctcagct 96181 gtcacaggaa gctgcttcgg ggggtgagca aactttttaa aatgcagaaa ttatgatcta 96241 cacccgtttc ttaaaagtaa gccatcgtac ttggttctct ttaattatat attttcttac 96301 atattgtgtt catgtaggca agtcctgttt ctgctaaaag aaggtaagtt ctaccaaggc 96361 ggtgtcatgc cagctttatt tcccgtggca cctggcacac tgctaagcac ttacatgctt 96421 aacaactaga ttgggaatgg tgctgctctg gggaagtggg cacacgttaa agaaatgttt 96481 atttcagtct tctgaaatag ggaattactc tggctaaaat gtagctccag aaagggaaag 96541 tggggctgta tgaatccagg tccagtttgt tgtttcctcc aggataaggc agctgtcgga 96601 ggggaaaatc atctcccatt tctccacagg gcagtctgaa gatggccaat tacacgctgg 96661 caccagagga tgaatatgat gtcctcatag aaggtgaact ggagagcgat gaggcagagc 96721 aatgtgacaa gtatgacgcc caggcactct cagcccagct ggtgccatca ctctgctctg 96781 ctgtgtttgt gatcggtgtc ctggacaatc tcctggttgt gcttatcctg gtaaaatata 96841 aaggactcaa acgcgtggaa aatatctatc ttctaaactt ggcagtttct aacttgtgtt 96901 tcttgcttac cctgcccttc tgggctcatg ctgggggcga tcccatgtgt aaaattctca 96961 ttggactgta cttcgtgggc ctgtacagtg agacattttt caattgcctt ctgactgtgc 97021 aaaggtacct agtgtttttg cacaagggca actttttctc agccaggagg agggtgccct 97081 gtggcatcat tacaagtgtc ctggcatggg taacagccat tctggccact ttgcctgaat 97141 acgtggttta taaacctcag atggaagacc agaaatacaa gtgtgcattt agcagaactc 97201 ccttcctgcc agctgatgag acattctgga agcattttct gactttaaaa atgaacattt 97261 cggttcttgt cctcccccta tttattttta catttctcta tgtgcaaatg agaaaaacac 97321 taaggttcag ggagcagagg tatagccttt tcaagcttgt ttttgccata atggtagtct 97381 tccttctgat gtgggcgccc tacaatattg catttttcct gtccactttc aaagaacact 97441 tctccctgag tgactgcaag agcagctaca atctggacaa aagtgttcac atcactaaac 97501 tcatcgccac cacccactgc tgcatcaacc ctctcctgta tgcgtttctt gatgggacat 97561 ttagcaaata cctctgccgc tgtttccatc tgcgtagtaa caccccactt caacccaggg 97621 ggcagtctgc acaaggcaca tcgagggaag aacctgacca ttccaccgaa gtgtaaacta 97681 gcatccacca aatgcaagaa gaataaacat ggattttcat ctttctgcat tatttcatgt 97741 aaattttcta cacatttgta tacaaaatcg gatacaggaa gaaaagggag aggtgagcta 97801 acatttgcta agcactgaat ttgtctcagg caccgtgcaa ggctctttac aaacgtgagc 97861 tccttcgcct cctaccactt gtccatagtg tggataggac tagtctcatt tctctgagaa 97921 gaaaactaag gcgcggaaat ttgtctaaga tcacataact aggaagtggc agaactgatt 97981 ctccagccct ggtagcattt gctcagagcc tacgcttggt ccagaacatc aaactccaaa 98041 ccctggggac aaacgacatg aaataaatgt attttaaaac atctatttaa tgtattttaa 98101 aataatttgt aagttgattt taaaaccaat ttaactacat tccaaattat agacagccca 98161 tttatatggg agtaactttt caggctcatt gcctcgccgg tgatgagaag aactagctag 98221 ctggaagctg tgggaaaaag aggtaaggta acttgttctg tcgaagttct ctaaattctc 98281 ttgcttactt gccacacccc taggccccca gcttccccta acccaaggtt tctggtattt 98341 tctcgtactt tatcaagact atggaatctt aggagactta acaaaagcaa atgagaaatt 98401 atgtttagaa atgtctaaca aaatgaattc tttgtccttt taagtataac acatacctca 98461 ggcctcacca gcacataact acaaaaggtt gtcccacttc ctttctgtgg ctgagttagt 98521 agaacacagg ctcccacctg ccacatcagc agaaggtcac ctcaacatgt gagctacctc 98581 cccggagacc ccccagatcc gtaaggatga tgcatccttg atcctaaaaa cattttcctg 98641 ttcctggtgt tcagaattgg actccacact cactggtctc tttataatct tgcttctggc 98701 cctttgaggc ctcaaagcta ccagggcctt gctgccaggg gacaatcacc gctcccggct 98761 gagtcctgca gacatagggc ctgggctggc tgcctcctcc tgctggccca gcatcttgct 98821 tgcactaaag agagctggag gcttggcact gatgcttgct aaaaacctac ccaggccgcc 98881 cactgctgcc gcactgcagg gcaccagccc acactcctcc cctcctggca tcaggcacac 98941 gttcacggca ctaaacctta caggaaagca gtggaaccct gtctttcctt cacaggaggc 99001 actttccttc ctaggcaaaa acgatgatac ccatgggcac agcatctcac atagggacac 99061 atagagatgt ctgactcatt aaaacccaag tctctggcca attaaaaggg gtccttaatg 99121 tcctactcaa cagtggtgga aggaaatttg ctctatattg atgaaatgag gtggagaaaa 99181 tctgattttc caaacatgag aattctccat atgccacccc ataaccaaag accccttatt EPI-109 1 162

99241 tgtgttagat gaaacattca aagagcctat taggatagcg gatgagaccc ccaagggaca

99301 tgcttataca acaataactg gctccaaacc acactccatg gcagtggctc tcaaatgcca

99361 gctcacatca caagccctgt gctaaaacac agagttctgg gccccatccc ggagtttgtg

99421 gttcaggagg tctggagtgt gacctcagaa tatgcatttc taacaaattc cccaggggat

99481 gcagatactg ctgacccaag gccctccttc tgagaaccac tgttccaggg agaagaaact

99541 cagctaagta agggtttggc tttgtgctga agacaatgtg gaatttagag ttggggtgaa

99601 ttattcagga aagtagagag gtttggagat gtgagggtgg gaagcgcagt ggagggaggc

99661 agagaggaaa tatgaagcag cgtcagttgg agagaaatta ggaagaggaa taaaatgata

99721 tatgccaggg atttcagttt tgctgagccc atgatgacag actcttctct ggcaccttat

99781 gccactcatt gagggcttgt agctggctct gctctttcag agtcataata gggctatggg

99841 tctgacctca aggtgagctg gaatgggcac aagtaataga taaaactgca agaagtcact

99901 caagggtcct tcctagaaca aaggatccct acattccaaa ggcgaatgcc ggtcactatc

99961 ataaaagaaa agaaagaaag aaactgatgg tgacatttta aatggcaatt tttctagctt

100021 ctaaaaggtt gtggagcaac tggaactttc ataccctgct ggtgggaatg taaaatggta

100081 taatcacttt ggaaaaattg gcagtgtcac caaaagcaaa gcctatacct actatccatt

100141 tcactcctca gtatttaccc aagagaaatg agcatgtatg tccatacaaa gatttggacc

100201 caaatgttca tgacagcctt atttatatag cctcaaacta gaaaaagtct gtctatcaac

100261 aggtgaatgg ataaacaaat actggcctgt gtatctaatg gaatactgct catccacaaa

100321 aagaaacgag ctattgatac acacaggagc atgcacgaaa tctcaaaatg ctgaatgaag

100381 gaggccagat tttaatttta tttttaatta tttatttatt tatttatttt tgagacagag

100441 tctcgctctg tcacccagcc tggaatgcaa tggtgtgatc ttggctgact gcaacctctg

100501 cctcctgagt tcaagcaatt ctcatgcctc agcctcccaa gtagctgtga ctacagtcat

100561 gcacaagagc aactgactaa tttttgtaat tttagtagag acggggtttt gccatgttgg

100621 ccagctgctc tcacactcct gacctcaggt gatccacctg cctcggcctc ctaaagtgct

100681 gggattacag gcatgagtca ccgtgcccag ccggaagcca gatatttttt aaaagtactt

100741 attttgtgat tctatttata taaaattcta gaaaatgcaa acaaatccat agcgacagca

100801 aatcagtggt tgctggagat gttggagggg agaggagagg aatagattgc aaaggggaac

100861 aaggaaattc ggggggacag tggatatgtc tgctattttg actgtggtga tggtttcatt

100921 ggtatataca tatgtcaaaa acgtaacaag ttgtatacgt gatttattat gtgttgacta

100981 tacctcaaaa aggctatttt ttaaaatccc cctcaggctc caggcactcc attacgttgg

101041 tgtgacttgt cttggaaata tactttgagc atttgccgga ggagatccag tgcctgggcc

101101 tctgtttctt ctcccaagta gaattggcag ctaaaacggg atgcccatgg gcacaacttg

101161 tcacccccat caccgaacag ggagcagaag gaggctgctg ggggtgcccc cacagggagc

101221 acagtctcat cgggaatgac ctgccatggc aaataaaatc accagggcaa gtcaagggag

101281 agaccaggga agagagtgat ccagtctata ttaaaaaagg atgagaaagg ttgaagaaaa

101341 agagaagaag ggacagaaat tctcttcaca catttgcaga agtaggtccg gactctccat

101401 ccacttctcc tcctccgata ggtaggacag gaatctcaga ggaaatggca tcatcttccc

101461 atgtttacag acacagcaat gaactcaaag aacaatctta tcaggatttt ccaaatgaaa

101521 acatggagca tatagagaat aaagatccat aaactcgtat ggtggctgag actgaaatgg

101581 ttaatgaaaa gcaaaagtgt gtgctgaatg acaccagcca caatggcctg aacacttaag

101641 tagtgtaata tacttggaac attgacagct aacaaggtct tcctcccatg tcagaccaag

101701 aacacagttt cctaaagata aaaatagcac atgcttttcc acttttccat aagtgactgc

101761 attagaaaac taacaaacca tgaaaagcaa aatatggcta gtctcttcaa gaaaaactgg

101821 tgtttctatt ttgtctgtaa attactttct aatacaaaaa acaattcctg ttacattgag

101881 gtaattctaa ctagggacat atgagagaga gattgaaatc tcatgagctg tctccttttc

101941 atctcaattc tgtgtactcg tgggtacaaa tggaactagt ttttgtttgt ttgtttgttt

102001 tttgagatgg agtcttgcgc tgttgcccag gctggagtgc aaaggtgtga tctcggctca

102061 ctgcaacctc tgcctcctgg gttcaagcaa ttctcctgcc tcagcctcct gaatagctga

102121 gattacaggc gcctgccacc atgcctgact aatttttttt ttgtttgtat tttttagtag

102181 agacagggtt tcaccatgtt ggtcaggctg gtctcaaact cctgacctca ggtgatccac

102241 ccacctcggc ctcccaaagt gctgggatta caggcgtgag ccactgcacc tggcccggaa

102301 ctagttttaa aacaggaaac agttgatata ctgaatggaa aaacaataca atttgaagtt

102361 gaaaaaacaa aataagatgc ccagttaaat ttaaatttca gttaagcagc taatagttat

102421 ttagtataag tacaacccat atacgacaat tgcagtattt gttatttatc tgaaattcag

102481 acttacctgg gcatcctagt atcctgtttt ttgttttgtt ttgtttttcc ctttgttttc

102541 ttttttttcc ccgaaatctg accaccttaa ctttaaggta tttattcatt tttaaaaact

102601 aaatattttt cggcagtcag aactagagca aagataaatg atcccaggac tctgtttagc

102661 aggcagtcag gaagtgtgac agtgtggtgg gtggcagccc cggccaggcc tttcctcttc

102721 cctaaactgc cacagcagga ctgccacact tgggaatccc agtttccatc tgagcagccc

102781 ctccagagtt tggaaggagt cagtgcttta gcctgaggag ccgtggatgg ctctaacact

102841 ttgcttgtcg gttgaataaa aatcaaccca aaggtggcct acactcattg aagtaggaat

102901 gccagaactt cagtggtgtc acatagaaga aaatatctaa gtgcttaggg agatggcagt

102961 gctagtggat ctactggatc attaagactc actcacccac ccagcgcagg tctagaggac

103021 acacccttgc cacactggga agtgtaaatg agctccagca tctttatttt tttttatttt

103081 ttatttgttt tattatactt taagttttag ggtacacgtg cacaaagtgc aggtttgtta

103141 catatgtata catgtgccat gttggtgtgc tgcacccatt aactcgtcat ttaacattag

103201 gtatatctcc taatgctatc cctccccccg cccccggtgt gtgatgtccc ccttcctgtg

103261 tccatgtgtt cttattgttc aattcccacc tatgagtgag aacatggggt gtttggtttt

103321 ttgtccttgt gatagtttgc tgagaatgat ggtttccagc ttcatccatg tcccgcatct

103381 ttaaaaaaaa aaaaaaatct ctaagtggtg gctcttctct gtagatcagg agctgtagtg

103441 agcaatgcta caaaactgga gtttctaaat acagggggga tggtgggatt ctgaggaagg

103501 acaggccacg tggtaacact tacaaaagac caagtgggtg tggttgccac tgtggacggt

103561 ggagccaaag cagtcctcag aatagtctga cccccagagg tctttggcat tggctggttg

103621 atcatggtgt ccctggaatt gaaatagaag gacggtctac taaattttta cctgatctgt

103681 ataagcagaa gagttctatc tctagtgaac agaagtctaa ctttagtcac cagaactgag EPI-109 1163

103741 agtcaattca atcaattccc agatttgaca tagtttatag acctagaacc ccttgaatga 103801 aaggtaagct ggctcccctt gaggaaggac cctgttacat ttccggcatt ttattctgat 103861 aatctttttt cccagccttc cccaaagcaa cttagggcca tttaccaggg aaagccatgg 103921 aggaaaagga aataattagg ctatttggag attccaggac actggctcta cgctgacacc 103981 agttctaaga gacccaaaat atctttgtgg tctaccagcc aaagtagggc ttcatagagg 104041 tcaggggtca ctagagtttg agctcaggtc tgtttcactg tgagtctaga gggtccctga 104101 acttatccta tagttattcc cccagttcca gaatgcagaa ttgagctgag agcagtggct 104161 catgcttgta gtcccaacac tctgggaggc gaaggtgaga ggatcacttg agccaagcgg 104221 tttgagacca gcctgggaaa tatagtgaga ccccatcttt taaaaagaca aagaaaaata 104281 aagaaaattg acatggaaaa ataatataaa atgtgaataa tctcacatct actaaagaaa 104341 ttcaatctgt aattagaact cctcccacag agaactataa gcccagtgcc cccatcaact 104401 ggagaaacag aaagaaacaa tcttcttaac agaaagcata attggaatag agatactctg 104461 catcggggaa gaatccccat attgattctc tgatccatag agtgaaggcc aagtggaagc 104521 ctttggaact ccctctacct gccaagatac taaacaaaac aacactgcac gtctggagga 104581 attgtagcaa gaacttgaaa gatgaaggat gatgatgtcc acctctctcc attcagctca 104641 cctatctggt ttgtgcagaa gacaaatagg tgttggaaaa tgacagtgga ccagtgtaaa 104701 cttaatcagg cgggggctcc agctgcagct gcaggatcag gtgttgtttc atttctgcag 104761 ctaatcaacc cttctcctgg cacctggtgt gcagatggca atttttcttt tctattatct 104821 gttagtaaag actatcagaa gctgtttatt ttcagttggc aaggtcagca atacactcca 104881 agggaagagc agtctgtctc agatcttacc gatgcctggg gatagggagg gagtggcccc 104941 ctcaccgtct ccaaggccta gtcctctgct cctgctactg gcagcaaatc cacgcaggtc 105001 tgcaacaacc tcaattcctg cctcctcaga agaaagaatt caattgaggg acgtaagaca 105061 gaaggagaga ctgaggcaag ttttagcaca ggagtaaaag tttatttaaa agctttagaa 105121 taggaacaaa aggaaggaaa gtacacttgg aagagggcca agtggacgac ttaaaaagca 105181 agtgcgtggt ttgacctttt gacttggggt tttatacgtc agcatgcttt cggggtcttg 105241 cgttatttct cccctggttc ttcccttggg gtgggctgtc ccatgtgcct gcctgagccc 105301 actggctcaa ctcctgagat cttataggga aactactgct caccagtttc gagtgttttc 105361 tatctattag gagccggctt ttccctgttg ccgggtgtga ccaattatta ctttagaaag 105421 acagtcaaca accgccagac catcacctga tggtcacctg acactcctgg tgtgtggggt 105481 atggggagcc ctctcctgcc ctgctctttc tgactagcta cccactataa cactcccaga 105541 gggacctgca cattttgtgc tctttgcaag acagtgcctg cccagcacct gtaggcctgc 105601 tcaccccttc agggtcatga tttttgcttt ttaccgcagg tacccataag caaaacatgg 105661 cattgttcac catgctttta cattattcac ataattttaa gttatttaca caacaatgta 105721 aaaccatggt gaaccatgcc acatgttgct tatgggtacc tgtggtaaaa atcctgctac 105781 tagctcattt tgcagtgtct ataatgacag gtaatgctcc attcactcct ttatgacact 105841 tgcaaaaact gagaacataa cgcctcccag ttaagcaggc atctgggcaa tgtgaggaga 105901 acagaaatag accacgctgc atttatctct cttgatgaca ggcattgaga tttccacttt 105961 ttctggtttc ttattatgtc tctactgggc attcttacat acatcttgca cgccatggaa 106021 agtttctcta gggcagtggt tcacaaactt tttggataca gaatactttt atgtgcttga 106081 aaactgagga ccccatacag ctttagttta tgtgggtgta aggttctagc ccaaactgaa 106141 gtccgaaggg agttggtggg tgggtgaggg gtagctgaaa aaacacccga ggaatcatag 106201 gcagtttgaa catggcctta tcctctctct gggcacgagc catatgtcca gtgtcagcag 106261 ggtaattata ccttttacag acaatagagg ctctgaagca atcacgagct cacgtgagtg 106321 gtcacctaat gcacctcaag tggcatggtt cataatgtgc ggagtcgtgt gcctacgctc 106381 caaacccact gagtcatggt gcaccaaaaa gtggcctcag cctgctcctg actaaagcgc 106441 agccatcttc cttacactcc acccctaggc caggggcatc ctccaggtag ggacatgtgc 106501 ccgtagggtg gagccctgaa tccataatcc acagcaacaa tacggagagc aacagctcat 106561 gactaggatt ccagctatgc tacttatgac tatcagggcc cagcgtaggc cagagcccag 106621 ggatgtctac catctctgca gggggtcatc agtaaggctc ttgactacct taatctcctg 106681 tgagacccct tgcagggctg ctgttatgtt ctgccaattg tcagggataa aggtacaaca 106741 ttgtgttcct aaaagggcac aggtgcctcc ttaggcagca gttactatgt ctaagaccat 106801 tcggtttcgc aacaccacct ttctgatctg atcaacctca tccattaatg ggaagagggc 106861 cactcaggtg taattcagag cctgagcagc atgctctgca agagcagtaa cttggcttct 106921 acagttgtga cacacactcc agggctagtg cctgtcaagg ggtaaaacca ccagggtgct 106981 cattacactt gcaaaaaccg agagtgtagc acctcccagt tatgcaggca tctgggcaat 107041 gtgagaacag tggcaggtac atgaggccac cctcaggtat aatgtccagt ccagtttgct 107101 tataggtaag gccaccctgt gtccccacag acccataaac tcccaggggg cacacagtcc 107161 atcgaggccc cttggtgggg ccgcgtcttc caccatacct ttggtgtggt gacatgtatt 107221 atgcttacac acactgtgac gggtacccat cccacagtgc tattacccca gtgttgctat 107281 atgcaccaca gtgcctgggc caggggtact gcacgttacc tcactagcca gccccaccca 107341 tcataaatgc tatgggccag ccagggaatg gctgtgctgt gggtcttgtg gcatcctttg 107401 tccaaaactt gccacgttgc gttccaggca tcagccatgg gaccccaagt ctccagccat 107461 gtctggttct ctgcagatgc tgaatgtatg tgctaaggca agccatctgc agctgctaga 107521 agggcggtgc agatccaaca gttggaaaca ttggtcactt cagtgtaggt gtgggcccag 107581 tccacaatgc agttggagca tgttaaccta cagttggaat gacagagtag gcataggtac 107641 taacagagga aaatcacatc cctcaggtaa aatacaggct aacctttcat ccctggataa 107701 caatgcagcc cccaaggggt tctgccctgg gcaatagtac cacacctttt cagctcccca 107761 tggttccttt gggtcctgta ttcatgcgaa agtcacaggg gagcttgtag taggccacac 107821 agacagtaca tttgaaccct ggaggaaagt ttcttccctg gccgttttcc tacaaacagt 107881 taacttcggg gaccattcat tgaacaccca aagagtgaca tacaagtcat actgtaggcc 107941 ctccccacag ggagctacga tggacaacca ccagcagccg ggggcttgga ggggctatgg 108001 ccacagccag gttttctgtt cccctgcctt cagggacgtt ggggcaggca acaacaggtt 108061 actgttcatc cccatacctg gtcagaggcg gttacccttg gtgtgtatct gcaactgaat 108121 aggggtggtg gcccatgtaa caaagcctcc acctgggctg ggctgctttt ccatggccat 108181 tcattcaagg tttggagcat caggtccagc ctggaacttc agccctgcaa agacaggagt EPI-109 1 164

108241 gtgacatgca agtaaaaccc attcttcaag agctcgctat atcactcaat catacccaca 108301 gcttgcaagt tgtgcggtac atggaatccc tactttatgt ccattgttgt gcctgttgtc 108361 cagtaaaatg tgtcccccat cactctcaat gaccaaaggg caaccatata gagcacataa 108421 gtgttgcagg gtctggatgg tgtgctgttg gttggccacc ctgcaaggat aggcaaacaa 108481 caggcctgtg gctgtgtcca cagctgttag cgcatgagta tacccttgtg acttcggcag 108541 cagcccaatg tagtctactt gccacctggt caagggcact tgccctgttg tcacttgtgt 108601 agcactggac agctgcctcc atttagggta tgcctgagca catgccgggc atttctgaca 108661 agcctcccaa atgtcttgca tgggcagaga cagaccccaa catttattga cttgttgcat 108721 cagtttaccc cctgcatgtc ccagtttccg gtgtagctac aaggccacat ctcatgtaga 108781 tgccaactct aaccatcgga ccttggccaa ggcttctgcc tcgtcattgc tgggggtggc 108841 cagaggcata tggcctgaca aatgataaat agttacatct ttgcaatgac ccatttccca 108901 gaggtcttgc tacatgggtt ggtggcccca aatgggttgg tggccaacta gccaattctg 108961 tattttccaa gtagttaaac acaaagttag gcctccatag actgcccagc tatcggtacg 109021 gattaccata ggtgtctccg ccttgttgat caccatccat actgctttaa attcagccca 109081 ttgactactt tgtccacatc tggtttcaaa ccatatggtt ttggtactaa gttggactgc 109141 aacactggtc caagcaggag tagcacctcg actagaccca tctgtgtgcc atgccccatc 109201 aggaatagag ggatgccctt ccttaaatgg cagtggctca gggtcaaggg gtgcctcagg 109261 ccccatggcc ttctcttgca ttaggactgc aggtcccaag acctcttgca actctgctgc 109321 taatgggctt gtgctcagcg tactctgttg ctccaagtaa gtgcctcact ttgccaaagt 109381 ggatgtctgc accatcccag tctggggggt cattacacat gaatgcaccc atcccgctgt 109441 caggtaagtc atccacactg tgactgtagc ccatcctatc acttctcaca agcctgaagg 109501 gcagcatata cagctgctag ctatttctct atcaaggaat accagagctc agctcctttc 109561 catagttggg accaaaagcc tcctggcatt ctcaggcact ctgtgtgctg ccacaggccc 109621 aaactaaaac catctgtggt cacatgcata tccagttcaa atgggcaccc cttgtcaaat 109681 acccacaggg ctcgtgcctg ctgaatagcc cacttggctg ccaggaagcc agtctcagcc 109741 acatcagccc aatcccagat tgctcccttc tttgttaact gatacaatgg ttttatcatt 109801 tgagctaaat gaggcaggaa tgtccaccaa tatcccagga ggctcacaaa agtttgcagc 109861 tgcctcaccg tggtgggcca gggatatgcc taaattttgt caatgatagc ctcttgtatg 109g21 gccttcatct tacccgacca gataactccc aagaatttag caggtaatcc aggccctcgg 109981 accttggatt tgttgatggc ccaactgcat gctgccaaat gttgccacaa gaggggtgcc 110041 actgcttcta aatctgcaag agaatcagag gttaacataa tatcatcaac gtaatggaac 110101 aagtggactc cctttggaca ttttcaggct gttaaatcca tggcaacaag accatgacat 110161 atggtggagc tatgcacata gccctgcagc aacactgtga aagtccattg tcatcaaggc 110221 aaactgttcc tggctctcta gagcaaggtc aactgagaag aatgcattgg ccaagtccac 110281 cacatagtgg tactgtccta attccattgt cgagtggttc atcaaatcca tgatagatgg 110341 cacagcttcc aagccatgta aaatatccac ctccagaatg tattcaggta tgggagagac 110401 atacacagtg tataagcaag gagccaagtg gccaatgcca aggtacagag atacaggttt 110461 cactttcact gactggcctc cgtaaccttt aatatatgca gatttgccca aaaacttaac 110521 tgggttccca taaacaaggc tacaatctat gccagtatct accagcacca gcacccactg 110581 tacattggtg ggggaccagt ggattgccaa ttccacatgt ggcctctggt catctggtgt 110641 ccccccaagc cagacacctt tggccagttc cctagttgaa cagaaaaggc tctacatttc 110701 cacctggctg cagcaagtag tctctgagct gggtaggacc aggtcacaca gcaatgcctt 110761 tctccccttt gggcattttc cggaattgct gccctgcata caactgtctc cgcaaagtta 110821 ggagtatttc attgggctgc ttatcaattt tctctcagtc aaccccagcc aaaatcaaat 110881 ctatccacat ctgtgagcgt gtcactcgtt ggggccccct ttttttatgg gggagccccc 110941 tgtgggtggg gtaacttccc cttctttatg gtgtggaccc tccaatcccc ctgaaggcct 111001 tctgcttccc tgagagccgc catggcagtg gttacttcat gtatgcggtg ccctacgtat 111061 ggggtgagga cagcagctag ggagccaaag gggctcagga gcatcaaacc caacatgaga 111121 tccctcatgt gggaggtgaa acatttatca tctggccctc aggtattcag gacaaacata 111181 gcctgccgca tacccatctc ccgaatgact tacaccaaat tggcatatga ctgccattta 111241 ctcacagttt tgggcatttc accagcatta ttccacacag ttcatatggc tgcctgtagc 111301 cactcagtca gggtgtggtc tccttgcgct gccactaacc acctgctcac ttgcagccgc 111361 tgacagagag aggggtgagt catggtggag gccagcttgt ccatctcaga ggtggaatgg 111421 gagataccat ctgctccctt gttccacaga cgaagcatcc aggcaggcag gggttcccct 111481 ggacactggc aacactgctt gcctaattcc tgcaactcag ttggggtaca ggcaatatac 111541 gaaatgtgtt gcattatggt ggggagtccc tgagtccacc cttggagccc cagtggctgt 111601 tcatgatcta ccttctgtca gaccaccggg tgagcccgca acaggggttc ttcctccttg 111661 gtatgaaact gagtggggat ctccagacaa gatgatggac ccaggcctgc attcatggta 111721 gcctctaatt ccttttccaa gctctgaagc cacacctcca ggcatcctgc ctgcacctgg 111781 aggtccccat tcatggcagc ctctaattat tttccagatc ggtgtagcca gacctccagt 111841 ctgcatccct cagggactgg gtgtgtactt ttcttagcac agttaaaaat gcccatccaa 111901 ctctgccagc aaaggctctc tccttcttgg tgctctgcac ttccagctgc ttcagcgcct 111961 tctccatgct catgggggac ccatctactg ccacccaggt ttccactcaa gcccaccctc 112021 acagcacggc taccaccggg taccacaacc catgttgtgg tcacatggcc aacctggaat 112081 cagcagggac cgaaggctca cttaccttag gatcctgttc gtgatgccaa ttgtcaggtt 112141 ctagcccaaa ctaaagtcca aggggagttg gtgggtgggt ggcaggtaac tggaaaaaca 112201 ctcgagtagg cggtttcgac atggctttat tctctctctg ggtgcaagcc atatgtagtg 112261 tcagcagggt aattttacct tttacagaca atagtggctt tgagccaagc acgtgctcat 112321 atgagtggtc acctaatgca cctcacatgg catggttaca taatgtgtgg agttgtgtgc 112381 ctgcctccaa acccactgag tcatgctgca ccagaaggct gcctcggcct actcctgact 112441 aaagcacaac catctccctt agagtgggct aaatctactg ctatttatac tattagaaat 112501 tttaacacag aagttttaaa tatttacatt gttaattgat tttgaaataa taagcccatt 112561 acaggttaac ataattaaca tacttttatt aaaaatatct gtatttttta aaagaaaaaa 112621 aattagcaac aacagtgatc cttggaatcg tcccacctca gcctcccaag tagctgagac 112681 cacaggcgca catcaccatg cgagctaatt tctatatttt ttggtagaga tgggatcttg EPI-109 1 165

112741 ccatgctggc cagggtggtc tcgagctcct aagctcaagt gatcctcctg cctcggtctc 112801 ccaaagtgct gagattacag gtgtgagcca ccacttctgg ccagaagctg gattctctgt 112861 cttgttctcc atccaatctg ttagactgtc aaatgccaaa taacctttgg aaaattctac 112921 tcgtaaaata aggagagaga taaataactt ctgagtatca tcattaaaat agtttgacct 112981 catggaccca ctgggtccca tgtggagaat agctctaagc taaagagtag aatggctggg 113041 aggggacata aacattcagc ccatagctgc tgaccacaat aacacatttt aagtctcttc 113101 ctctcctgct ccttgtgatt gcagacagac tcaatctgta ggagagctgt agagagaaca 113161 agctcaagcc cctgattttg cctacaaaga aagctgagcc cagcaaagtt aagggactta 113221 cccaaggtca cacagccaca cagcagagct ggggctgagc tccaggtgtc ctgctacaga 113281 ggccacttct ttctcccact agggactggc ctgtgattac ttcagaaaac aatggtcagc 113341 taactgattc tgaacgccct ttgctggtaa aagctaatct cctgaggaaa aatgtatgca 113401 ttggctgggc gcagtggctc aagcctataa ttccagcatt ttgggaggtg gagacaggtg 113461 gatcacttga ggtcaggagt ttaagaccag cctggcagtc atggtgaaac cccgtctcta 113521 ctaaaactac aaatattaag ctcggcatgg tggcaggcac ctgtaatccc agctactgga 113581 gagactgagg caggagaatc gcttgaaccc aggaggcgga ggttgcagtg agccgaggtc 113641 gcaccactgc attccatcct gggcaacaga gtgagattct gtctcaaaaa ataataatag 113701 taaaataaaa ataaataaac aaataagtat gcatcacctc aggtggtcag tcagctttcc 113761 caagacccca aagcacacaa tgttctttct ggtatgagtg acatggggtt cacagcacca 113821 caaagtccat gacttttccc tcagaagtga atgcatggct aattattttg tattttttgt 113881 agacatggag ttttgccatg ttgcccacgc tgctctcaaa ttcctggact caagtaatcc 113941 acccacctca gcttcccaag gtgctgggat tacaggcatg agacaccgca tggcctgcac 114001 ctatagtccc agctatcagg aggctgaggt gggaggatca cctgaaccgg ggaagttgaa 114061 cctgcagtga actgtgatcg ctccggtgca ctccatcctg ggcaacagag tgagatcctg 114121 cctcaaaaaa aaaaaaaaag tgaacacaca tgctggggaa gaggcctgca ggcacccctg 114181 ccagttctgc accagagcac actgtagcag ccctgctgtg atgcaggaag cagctccagg 114241 tcctgcagtc tgaagcatgg agcctgaagc ctggagcccc ccatccaatg ctgcgccatg 114301 ctcaccagta tcccccagca tcagcaccga ggcaccagct gcagataaat ttctcaccta 114361 aaatgttgag agatgttgct aaactgtcct tctaagggta tgtataataa tacggtcctg 114421 ccgatactga ataagactat ctgtttcatt acatcctcac aatactgaat atcattagca 114481 acttgaattt taaattgtgc taatcaatga aaatgattgc ctaattacta gtgagttgag 114541 gttatttaac attaatactc cttctgatga aatattttgc atttatcaca ttttacataa 114601 attctctcta tataattagc actagaatgt ccgacttggt tttcattgtt cctcacctgt 114661 ttggaaacac attaagaatg agggagagaa tggatgggga ctcacctagg gatgcatgga 114721 gctggtcggc agccactctg aggccctctt aacacttccc caccacacac ttaatttccc 114781 ctggtttgtc catagataca tccaacaatt tttatgtaaa taagaaagac tcagctttca 114841 atggaaaatg gtaggttgga ttttatgact gaagtggcaa aaagaaataa gggattttat 114901 tatgggggag gtccaaaccc tggtgaaaaa cgaaattcat tgaaattgtt tgaaaattca 114961 aggattaaat cagattattt tggattcagt aggaattaga ttactttaaa gccccaggat 115021 actttattct gtagaatgca tggaaagtat agaaaagaga aacaaagagg gaaagtcatg 115081 gctaataacc tggaaggggt aaatagggag ccaaaggcct gtgggacgta accaactcag 115141 cattccactg gaggctttat gatcaaatag caagctattt atcatgaatg caggatgtgg 115201 gcaaactcac gactgctccc actgccagaa ggtttgctga gggcaatcac ttcctggcac 115261 cgagctcctt gaggttatct actgggacat ctggagaatg cagtcttgca agcctactct 115321 ggacccagca gctgacccct tcttccatgc ccctcttcct gctatctctt ttgcctaata 115381 aatatggagg gctgtgtaaa gctcagggcc cttgtccact agaggcaaac tgcccgctga 115441 ccccttcttc caaatatgct cttttgtctc atgtctttta ttcccgcttt caccccactt 115501 tgttcagtcc ccctagggcc gtgtgggtta catagtggcg ccctgaacag cgacagaatc 115561 aggtgctcta caagtggcgt ccgaacacag ggactatgag gatgtgaatg aagaagatct 115621 gctggagcag aggaattgaa attgacaagg tgaatgggga tcccgggaca agtctgccgg 115681 cagcagatat aaggtcagtg ccctaaagag gtactgggag cagtgcctta aagtagtact 115741 gggaatggga agttttctga atcagggtaa catggggcag aattggtctg ttgaagaaaa 115801 acattatgtg cagttgctta aagttttgtt gaaacaaact ggtgctcagg ttagttctca 115861 cattaactac gatgctacag gaagtcatta tgcataaccc atggtttcca caggcaggga 115921 ctcttgatgt agaaaattgg gatagagcag aaggattaaa acaggctcat caaaaaggtt 115981 ttcaagttga ttcttcagtt ttctccactt ggagtttagt tcgtactgta cttctgccat 116041 tatctccttg ttattctgcg ggacagcagg ctgaatgtaa aaatctgaaa gaatctgttg 116101 tcccacccac agctccagtt gaaaataagt aataggagag ggaggataaa aattggccta 116161 taccgccccc tccagttgca gaaacatctg taccgcctcc ttcggtggca gaaacagaga 116221 ccccaataca aagaatttta cgctctgccg ccacggctgg agagccctta ggaccttgca 116281 cttttcctat ttccgtaagt cctgatccaa ataatccaca gcagcttaat catgaacaca 116341 ttccactaga gtttaagttg ttaaaggaat taaaagtgag tgtggtaaat aatggcatac 116401 agagcccatt cactttagga ttgctagaat ctatgtttgg tgctatgtgt cttttaccct 116461 ttgatgtgaa acacttggca tgaacttgct tgtctgctag cgcatatctg acatggaatt 116521 taaactggca agaacagggt gcagaccagg ctagacagaa ccatgctgct ggaaatggag 116581 acattacaga ggataggcta ttgggtaatg gcccttattc tgacctggta catcaactag 116641 cactcacaaa tgctgcttat cagcagtgca cacaggctgc taaatgtgcc tgggccataa 116701 ttcctgaaga gggagtccca gtactatcat ttttacatat catgcaaggg tcacaggaac 116761 cctacgcaca atttcttgca agattacaag aggcagtgag gcatcagatt cctcatacct 116821 tggctgcaga aatgctaacc tttactctag cttttgagaa tgcaaatgca gattgtaaat 116881 gtgcactggc accggttagg tgtacaaaaa cttgggaaat tttctcagag cttgttaaga 116941 tgtagcaact gagctttatc gatctgcaat gttagctgaa gcaatggcta atttagctgt 117001 tgacaaatct aaaaagagcc aagggtcaaa ccctaaaatg ggaaaatgtt ataattgtgg 117061 aaaaactgga cattttaaaa aggaacgcca ccagatctca ggacagaaag gatcttacaa 117121 tgcttttccc cccggccccc agcggaaaga acacctggac tttgtcctcg ctatgacaaa 117181 ggaaataact cggctaatca gtgctgctca aaatttcatc agaatggcac ccccctgttg EPI-109 1166

117241 ggaaatgaga tgggggcctg tacccgggcc tcacaaacaa tgagggcatt cccaattcag 117301 acctcaaccc tgtttcaggc atgggttccc agaggcatat tgagtccctc acccgaggaa 117361 ctccaggaag tgcaggatta gatctcccag ccagagaaag ggttacataa ggtggggaag 117421 acaaacccac caagattctc actggcattt ggggaccttt accagcagga tatatgggac 117481 taattttagg caaaagccac cttaacttgc aaaggcatta ctgtagtccc agaagttgtt 117541 gactctgatt atgaaggaga aattcaagta gttttattgt cacgagatct tcgggttttt 117601 gaaccgagag aatacataat gcaattatta cttattccct gcaaattaca cccttctcca 117661 tgaaaggaga aacaaggaaa taaagggttt gggagcacag ctacacggga aatctatcta 117721 tcccgaccca tagcctctaa tagacccacc tgtgtagtac aaattaaagg aaagaaattt 117781 tatgggttta tggataccgg agctgatgtg tcagtgttac cagcaggtct ttgttcttag 117841 agctcccaag atggcggcaa gccttttgtt ctctgacctg gagttcttgg cctcacagat 117901 tccaaggaat ggatccttgg gccatgcagt gagtgtcata gctctattag aagctcttcc 117961 aaaagtcgtg ctgctatcta tggactaaaa catactcaaa caataatgac ctctggcgtt 118021 taggctcaat gctcagagct aattgcagtc attcaggttt tacagctcac agcttcagat 118081 cctgtcaaca ttgtctgtgt tcagtttatg tcgtaaatgt agccggtcac atagaaactg 118141 ctacaattaa aagtacgcta aacccagaac tgctaattta tttttaagac ttcaacaagt 118201 tatttgttct agtgcagctc cttttcatat ttctcatatt ccttctcaca cacaacttcc 118261 tgggccgcta tctctaagta atgagaaaac agacaaactg attgcctctg tgtttcagca 118321 agctcaacca tctcatgtgc ttctgcacca aaatacttcc gcccttactc acatgttcct 118381 acaggtttgt attatattat gcagtatatc cctcgagcca cacctataga aggatgtaat 118441 ccacgaggtt tggctccaaa tgaaatctgg caaatggatg ttacacacac agcaaccttt 118501 gataagctga gctatgttca tgtgactata gacacttatt ctcatatgct gcctgctaca 118561 tgccaaacag gtgagacagc tggtcatgta cagcgacact gtctgtcatc atttgctcat 118621 atggggatat ctaaacaatt aaaaactgac aatggacccg cttatactag tcatgctttt 118681 aaaaatttct tgcagctttg ggctataacc cataaaacag gaattcctta taatcctaga 118741 ggacaaggca ttatagagca ggcacatcaa acattacaat gcatgttgaa aagacaaaaa 118801 gcgggtatag gaggccaact accacctcaa taaaaactac atttagcctt atttacttta 118861 aattttttga ctcctggtat ggatggtaag actccagcag aaagacattg gcaagtgtta 118921 gaagaaaaga ggaaaattta tccaaaagtg ttatggaaat ccctggaaga aggaaaatgg 118981 aaaggtctgg tggatttact gacgtgggga agagagtatg cttgtgtttt tacaggagat 119041 ggacaagccg tgtgggtgcc ctcaaggtgt gtgcaaccat ggaacgggag actagaggaa 119101 cccagggtgg ccaaccatgg acagggtccc cccggtacga gccatgagcc agctgagcct 119161 gagtgcaaag acggagagaa ggccaactgg agtcacaaca cagttctaat gttatatttg 119221 taaagaatat cactactcaa cttacagttt gtgtttatag atatagatat agatatagat 119281 atagatatgg atatagatat agatatagtt atagatatag atagatatac actttaagtt 119341 ctagggtaca tgtgcacaac ttgcaggttt gttacatagg tatacatgtg ccatgttggt 119401 ttgctgcacc catcaactca tcatttacat taggtatttc tcctaatgct ctccctcccc 119461 cagcaccgcc tcccaacagg ccctggtatg tgatgttccc tgccctgtgt ccaagtgttc 119521 tcattgttca atttccacct atgaatgaga acatgcagtg ttttattttc tgttcctgta 119581 ttagtttgct gagaatgatg gtttccagct tcatccatgt ccctgcaaag gacatgaact 119641 catccttttt tatggctgca tagtattcca tggtgtatcc ttatgtcttt ttgacagcta 119701 agaaggacca gctccaggta aacaataccc aattgacctg taaatcttac caattatatc 119761 actgcattaa tcatagcaca ttgcaaacac ataatatctc tactttgatg attttaggcc 119821 acatccctgg gctatgtatt cctgttaatc tgtccgaggc ttgggctgcc acacctgctt 119881 tgcattttgt gaaacttctt ctaactgagc ttactcatca tgtctgtaga gccttagaca 119941 taataatttt agctattgtt tccttggtcg cactaataac ttctgttgtg atgtcctctg 120001 tagctttgca taattctatt caaacagctc agtacatgga gaactggaca cacacagccg 120061 accaagcatg gctacttcag aataaaatta acactgagtt acaaactgaa gtggtgttat 120121 gggaagtcag ggaccccaaa gagagggacc agctggagcc acagcagagg aacgtaaatt 120181 gtgaagattt catcttaata cggatattta tcagttctca aataatactt ttacaatttc 120241 ttatgcctgt ctttaatctc ttaatcctgt taccttcgta agctgaggat gtgcatcacc 120301 tcaggaccac tgttataatt gtgttaactg tacaaattga ttgtaaaacg tgtgtttgaa 120361 caatatgaaa tcagtgcacc ttgaaaaaga acagaataac ggtgattttt atggaacaag 120421 ggaagacaac cataaggtct gactgcctgc agggtcgggc aaaaagagcc atatttttct 120481 ttttgcagag agcctataaa tgaatgtgca agtaggaaac atatcgctaa attcttttcc 120541 tagcaaggaa tattaatatt aataccctcg gaaaagaatg cattcctgag gggaggtcta 120601 taaatggccg ctctgggaat gtctgtcttg tgcagttgag ataaggactg agatacgccc 120661 tggtctcctg cagaaccctc aggcttacta gagtggggaa aaactctgct gtagtaaatt 120721 tttggtcaga ccagttttct gctctcaaac cctgttttct gttaagatgt ttatcaagac 120781 aatacgtgca ccactgaaca tagaccctta tcaggagttt atgatttttc tcctgtcctg 120841 tttcctcagg agcatgtgat ctttgttctc ctttttgccc tttgaagcat gtgatctttg 120901 tgacctactc cctgttctta caccccctcc ccttttgaaa tccttaataa aaacctgctg 120961 gttttgcggc tcaggtgggc atcacggtcc taccaatatg tgatgtcacc cctggaggcc 121021 cagctgtaaa attcttctct ttgtactctt tctctttatt tctcagccag ccgacactta 121081 tggaaaatag aacgaaccta cgtgaaatat tgggggtggg ttcccccgat atgtgatgtc 121141 acccctggtg gcccagctgt aaaattcctc tctttgtact gtctctcttt atttctcagc 121201 tggccaacac ttatggaaaa tagaaggaac ctatgttgaa atactgaggg tgggttctcc 121261 caataaagtg gtaatgttga aatccacagt tctatggtta ggggaaaagc acaaagcttg 121321 caattgcagc agcaattgca ttgtcatttt aatcacactc atatttgtgt aaccaactta 121381 gaatataacc aaagtgagta tctgtgggac gttgtgaaag cccatttgca gggagctttc 121441 acatctaaca tcacctttga tattggtgaa ttacaaaaca aaattcttga tttacatagg 121501 caaattcaag agtttctgcc ttctttagaa gactggacca aattccagca aggcctggag 121561 agcctcaatc cttggactta tctaaggcac tacattaaca tcttacatgt agttcttgga 121621 ataatattgt tttgtctctg tcttctgttc atagcctgta aaattggatg gaccaccaat 121681 cggaaaatga gagctgccca ccctggcctt acattctttc aattaattca taaacagaaa EPI-109 1167

121741 gggggatatt tagggagcct aaggctcgtg ggactgacca actcatcatt ccactggagg 121801 ctatatgata aaacagcaaa ctgtttatca tgaatgcagg atgtgggcaa actcacgact 121861 gctcccactg ccagaaggtt tgctgagggc aatcacttcc tggcaccagg ctccttgagg 121921 ttatctactg ggacatctgg agaatgcagt cttgcaagcc tactgtggac tgagcagctg 121981 atcccttctt ccacgccccc cttctcacta tctcttttgt ctaatcacta cggagggttg 122041 tgtaaagctc agggcccttg tccactagag gcaaagtgcc ccctgaccgc ttcttccaaa 122101 tatactcttt tgtctcttgt cttttattcc cacgtttgcc ccctttgttc agtttcccta 122161 ggtccatgtg ggttacatag tggcaacctg aacaatgaca gaatcaggtg ctctacagaa 122221 ataacttttt aaggaaagat ttgggactta gagaccccag gagacataca caaaaatgat 122281 aagaggatgt gcccaaacca gtcttaaagt tgtggcacag ggtgaggaag atgaagctgt 122341 tactgaacct cagagagtga ctggtgttac agcaaaagtt agcaatggcc tgaagggagg 122401 gtttctgaaa tcaaatatga atgattcccc ctcagggaac ccaaccttgg gaactactgc 122461 atggttctct gtatgggaaa atatcattaa tgcaggataa attgtgaaat atcacaggaa 122521 gcatcctgca tctagtcaat cttctgtttc tggggtggcc tgtgcagctg tgcaggcaga 122581 ggcccaacca tcctggtgag tggcacacag ggactgagat ccagccacac ctaccaggcc 122641 atgctctggg aagggggtgg gacctgggca aaggacacct ctctaggact gcacagaagc 122701 ctttgtgggt gggtgggaca ttcctgtgat ggccttctgg ctgggcacta tgaaatgctc 122761 tgaagatttt tccttgcact gttgcactaa ccccagtcct ctatcactgc cccttcctcc 122821 tgggcgactt cactgatgtt gtggccatgt gaattctctg gccaatgaaa tgataaagat 122881 gatatggcct ctgccaagca gacactgtaa gtattattgt atgatgcttt tgtctctttt 122941 tttaaagtta aagcagttta ttaagaaaat aaaggaataa aagaatagca ctccataggc 123001 agagcagctg cctctgtctc ttatattttc ccctctgcct caagcccaac atgcccaaaa 123061 ttggggctgc tggttcagcc tgggtctcag aataaagaca tgagccacag atccattgct 123121 gacccatgat ggagatggac acaagagaga aacacatttt tgtcatgtta gccactaaga 123181 ttttgatttg gaggccattt gctacagcaa tataacctag cgtgaacaga gagacacagc 123241 gatgttccat ttcttttcaa cctggaacag gagaatttca taggtgggcc tcaatttcac 123301 tttagtatct tatttagaca agaaagttca tactgttcaa atgtcatgtt taagagtgct 123361 ggcattatca ctgctgtggc taccccatca gatgttgctc actgactaat cttctcatgt 123421 tagtgaggat ggacaacata tcaggccata attcaaagta gcaaatagga aaagagcttc 123481 atcctagcat tatgggacct taattaatgt cctttcctga caggtttcag aggcttttgc 123541 aggcagcagc agagctattc atctcactga cagtggggaa catggccaaa tggttgcccc 123601 cacaatggag gcagagtttc aggacacttg tctgatctct gcccttgaag gaacagtctc 123661 accctgattg acacttttgc ctgttatgtc caaagaacca atggaaaagc aggaaaatta 123721 ttccttcttc atttctctct tcattattta aaattattct gtcttcactt ctctctcctt 123781 ttctctgctt cctacttagc tctttagaaa tgcaattata atcttttatc tccccttcac 123841 cagacactcc caacagggca agttcatcta actatgtgct cttagttaga cgctacagag 123901 cagaactctc tcccaccaag agactacctt gagacataac agtcaattca caagccaaaa 123961 tatgcccgct atgaaactct cccatctgga aattttttgg ctgcttttac aacctagttt 124021 tgcccacaaa ggcaccagca gtaaccaact caactgcctg gtagacaagg caccaaagcc 124081 agtacccaga ccctctacct gctcacttcc tgccttgcat gccacgcccc ccatttaaaa 124141 gcctctgctt tctgctccaa aggtgaagca gttaccctta aggaaagaag cctgtacttc 124201 ttcccctaag gtagctttgg aataaaagtc actttatacc aaacctagct cttgttaatt 124261 agactctgca agtgatgagc aactgaacct acatttcagt tataattcct atgcttgttc 124321 ttcctgccct gccttgggga cacgcacaca ctcccaggca catacatgca cgtgcactga 124381 gacagctatg tgaataacca acaagatccc cttaggaaaa ccggtgcttg gcctggcctt 124441 aaattccaga cccttgggca tcatacccaa gactgcaaga aagaggaggg gctggacctg 124501 aaaaacttgg aagggaaggt ccaactgtac aggtattttg tcaggcatgt gatttcagta 124561 taaaattcta gaaaagatga gtgacacttt ataaggagag aatatcaaca aaatttctca 124621 ttttacttct tgctaagacg acagcaggga attgtaagca gatggatggg caatccccac 124681 cttcagcagg ggaggccaag gccccaacac acctggggag aagagctggg ggcagtgaat 124741 ggctgaggct ttcttgggga gctgggccat cttcttcggt tttacttcct gaggaattca 124801 caggcttcca ggagggctgt gggacacaac agagcaagag attcagaaac tgatttcttc 124861 cattaaacca gttatttaat ccaataaatc aaagagaata ctaagagttt tctctgccct 124921 tctcccatca ctgagtcagt gcttgccaca ctcatattcc cactccccta ctcctagcga 124981 ctacggtgtt caagggagcc agagtctagc cctcaccagc cagggtgttt ccctgctctg 125041 gcctgagaga cacaaccacc ctgcacttgt ctctgattga atcgactgtc acattctcaa 125101 gttcacaaga cattggtggt cctctagctt ctcccggaat gtgaacctgt ttgcaatcat 125161 gttcacctgc agattcactc attcattcac agatccttac tgagcacctg ctttgtgtga 125221 gttgctgtgc taagtgctgg ggacacagca tggatagact ggcctgccct caagaagcat 125281 gtggtctatg cagtcctgag ctggctgctc acaagaagag ccctgtagcc atatttctca 125341 gagggtggtc ctgacctgca tcacagtgac ctgagttgtt tgtcaataca gaaaagggtt 125401 tctcaacctt ggcactattg acatttgggg cctgataata accctttatt gcagggggct 125461 ggctgtgctt tgtttagtag catccctggc ctctacctat ttgttaccag cagcaccctc 125521 tatgttgtaa gaatcaaaaa aatgcttctc acattgtcaa atatcccctc aggggaaaaa 125581 ttgtctctca ttgaaaacta ccgataaaga catttctggc cctgccccca tccttggacc 125641 aacagcatcc ctaatgcccc caactctggg tgagggacca ggaataggaa tctgaatgat 125701 tgcagtgcac agggagctgt gcacactgaa atcccacagt tatcaccggg agccttacaa 125761 tactctgtga tgtcttctaa atatttttaa gggattaaat taatatcaac atatttccct 125821 ggttaagatg tgttttccta cacttgaatt tttttgagat tttgttttct ctatagttgg 125881 catctatggt aactgtctag aatcagattt tttttttttt ttttttgagg aagggtcttt 125941 cggtgtcacc taggctgtag tgcagtggta caatcatagc tcactgcagc ttcaaccttc 126001 tgggatcaag caatcctcct atttcagcct ctcaagtagc tgggactaga ggtgcttgac 126061 accacaccag gctaattttt aaaattattt ttgtagaaca aggtctctct gtgttggcca 126121 cattggtctc aaactcccgg gctcaagcca tcctcccacc tctgcttccc aaggtggtgg 126181 gatgacaggt gtgagccatc acacctggct ggttttgtca tttctcaatg catatgtata EPI-109 1168

126241 tatgcacctt tcattttact gaataaaatg gattatcagt ttccaaagat ttcatgacag 126301 tgccgtcact atccgtacta taaaatttat aaaaatttat tacatactgc tctattttat 126361 tctctaatta ttttatcaat gagattataa tttcctgaac tgtaaagaga tattatcttt 126421 ccttaacatt tttacacctg tgttcgttcc tagaatgctg tttggccctc aaaccttgac 126481 cttcacccat ggtggtttct cggggatgct agctagggtc tacttacggg aggttgagca 126541 ctttttcaga ttagtaatgc ctgcgacata ctgtggtccc aaatattttt catatgttgt 126601 tttgccatgg agtctggcca gacactcagt gttgtcattg aacagaaggt ttttggtttc 126661 agactggaat aagcaaaact tgtccgggca gtcagatcca tttctcccaa atttagcctg 126721 cgacaaaagg gcagacagtg agtagctaag gaaaagagga atttgtgggt taaaggaggc 126781 aaaggggtat ttcttccacc caagaacagc cctgagaaaa ccatggggca gaaggagctg 126841 agttctggag tcattccacc tccttagtgg agtcccccac cccacactcc tggtggcagg 126901 cccgccttgg gcagcatcca ggcctcacac cacttctggt cctacctcct accatctgcc 126961 atctttcctt ccttcttaac ctgtgacctt ttcccataca acttcttatg ggtgacaagg 127021 caacaatgga ggggttttga gatctgccct cacaagtcaa ttgctcagga cattctaata 127081 tgcagctctt ctagagaggc aggctgctag gaaaacccag gctcagccac taaccagctc 127141 agtgtgcagg tcggtcaccc tgcctccctc acacagttcc tgctctgtcc caggctccca 127201 tgtggggaga ctgagaccca aacccctcag tcacggcagc tctctcacca gcaccactgt 127261 gtgtgcacat taagagctcc ataaaggcca gttatggtgg ccagtcttgt tattcctgag 127321 ttgttttctt caaaagcaca cagagacatg atgttatatg ataaaaatag aagttctaat 127381 aaaatcccag attttaagaa aattttggga tttcgttcaa atcacattta gagagcccta 127441 aatctatagg gcaccttctg agtttgctgt tttagaggcc tggtctagag cactgttcac 127501 tcggcccagg ttcaggaaat gtcacctgag taaaaagcac tatactaatg catgtgggag 127561 gaaggctcag tggcttcctc atttgccaga agaacagcag gagggaaaaa gacagcctct 127621 gagccaggca gtgatggcaa caaggccagg gcacagagtc tcagcagaaa tggagtgagt 127681 cccagaaagc ccagagtcaa aagcctctgt tgttcttgtt gacactctgg gcaacgccac 127741 agcatgaagc caatactctc accatgagct tcaagtagag gactagagag gatcgagtgg 127801 gctggtgcac ctagctctgt gatctcctca cctaacatga gcccacacag ctaagaaagc 127861 actagaagcc ctgtggtcca tacctgttgg tggagcaaca cctgtttcag gcgttccacc 127921 ttatccatcc gagacaccac ggcatgattc ggggccatgg caagatggca gcttctagcc 127981 tcagtcacag gcttccgttt gccatcgagg cacagcagcg caaagtctgc cagcttcaaa 128041 tccttagccc atgcgtcatt gttatttcct ggggagaaaa agaaggtggc atcatccacg 128101 cctcccctgc ttagccaaga agtctcttct gggtgggtgt ggccattcca ctgacctccc 128161 aaatgcacac actggggttg tggtgatgtg aggaacagag aaggagcttc atcctacaca 128221 agctgtacaa acttcaaata taccaaatat tagtgctgtg tccatgcaat ggaatgttat 128281 tcagcaataa aagggagtga agttctggta catcctgcaa tatgcatgaa cctcgaaaac 128341 gatgctaagt gaaagaagcc agtcacaaaa gaccacacaa taggctgggc acggtggctc 128401 atgcctgtaa tcccagccct ttggaggcca aggtgggaga atcacttgaa gctaggagtt 128461 catgaccagc ttgggcaaca tagcaagacc tcatctcaaa aaaaaaaacc caccacatat 128521 tatatgactc catttatatg aaatgtccag aataggccag cctatggaga cagaaagtgg 128581 attgatggtt gccaatgctg aagaaggata gggcaatgac tgataatagg tgcaagggtt 128641 tctttatggg aggatacaag cgttctagag ttggattgtg ttgatggctg cacaactctg 128701 tgaatgtgct ggagatcact gaattgtaca ctttgcatgg gtggattttt tagtatatga 128761 attctacctc aataaagctg tttagagttc ttattttttt aaagaagaaa accctccacc 128821 tatgccatat ttttcagtga gttccagaaa aagaatagat ggtttacatt caaggagaaa 128881 ttggtttctc ctccctttca tattcaaatg ctattagtgt aaccagagaa aggaaaggaa 128941 cttttatagg tttatcaaat atatacagcc aattctaaca aaatacagtt gtaaagtacc 129001 ggagaaagtt aaaattaaat ttgacatcaa tctgatccct ggagattact tcagttaatg 129061 gcttgtaaat tctaaatgta attgtatgca tgtctatgtt tgtgcagatg ccggctcatt 129121 gttccggctc ccgtttgtct ctctgctctc tccctttaag aaagcacttt attcattctc 129181 ttggattcct ctatttgata ttgaaataat ttcaaattta catgtcttgt tttaatctct 129241 gtcccaagag acactagaag gagcagaagc agaagggaga agtggctgag actgcagtga 129301 ttactgaagg agggaggccg aaagtggaga cagttctttc tcaggaaaca gaatagcaag 129361 tcacctgctg agacttgggg gttggaatgc tgaagtgggg ctaaggagac agatgcagat 129421 tggaaggtag caaatggctg aggaccagga gagagagtga ttgttcaaac attggctgga 129481 agattatctt ccatcatctg caaccacctg taattttgtt cccactaact cccaaggagt 129541 ctccagacca aggctcacat ggggatgaat gaaggcctct acttcctttt tcataaaggg 129601 aggcttcatt tgcatatgtt cacccagttt gtagcatcat ccacagtttc caataggcat 129661 gcatgatctc atgtgggcag acagtgtgtt tctgtggttg actagaggaa gccagggaga 129721 catttgctac tgagcatggc tagtatctgt gtgtgtgaga gtgagtgtgt gtgtgtgtgt 129781 gtgagagaaa gagagagagt gtgtgtgtat gaatttcgtt tcaaaatcca tatgacacct 129841 acagatgtta tcatgttgtc tattgagata aagaattttg gagttctttt aatcacaaat 129901 atggaaaatg ttataaaacc ttcccaaagg caaatctgaa cactaagatg tgttgtgatg 129961 ccaaagactc tgctttgaag gagaaaagga aacaccttca cctaccatca gtgttctgca 130021 agacagtgac atctttcaca aatgcaacgt ctccagcatt ctcagccagg cacctaaaat 130081 gttccagaaa atatacacat aattacagaa gagaaactag tggggctttc ataaatattt 130141 gtaatatgca ttccaaaaac tgaaatatgg aagtaaacat ctaaaagaca actatttcta 130201 ggaatttact gtttacagcg gcagattgaa cacaggtgta cctgccctcc ttttaaaacc 130261 ctatataaaa gacattacaa aaccaagaaa tctaaagata tgcgacccag gaaacaggca 130321 atctaacatg aagtaagaca aaggaaagca ccaaaataat ggtcaacagg acccccagga 130381 ccacagatgt gcaggcggcc tacacagcaa ccagtccaaa ctgcagcagg aagatggatg 130441 ccttctggag cagcacttcc aagtaaatga tgaaactgtg atagcaccca gagagagaga 130501 gagagagaga gagagagaga gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 130561 gtgtgtgtgt atgcatgttg ttaggagatt tacattactg gcagacagtt tggggatgag 130621 atagtgatgt gtttttttaa gtgcagaaaa ttaagcaaat aagaaaagac atttatgaac 130681 tccagagtaa acaaaaagtt tgtacaataa gggaaatata atatgagaat aacgcttaca EPI-109 1 169

130741 cagtcataag tactgaatat gacattagcg tgttgggtgc tgaagagagt tgaagtctgt 130801 ggttgtgtgg tggaaaaggt gctgggggca gtgtgagagg ctagatcttc ttctatacta 130861 cagagtcagc agaaagttaa aaattaagaa ccagcattat aaggatgata gaaataaagg 130921 ggtatgacac tggtttcagc ttttaatgat tttgctataa atttccccaa tctagattct 130981 agatataatt taaacaaaag acaagggatt ttcttccagt ataattagga atattaaaat 131041 gtgggtgttt ccagtgaact aataccttgc tgcaggtctg aaaaaaaaaa aaagaggagc 131101 acatgcttct ttcgggctct tatgagacat gtgttcagca tttctgagta gaatcacatt 131161 tccatttgca aatccttagt cccttaaaga tatttttata cattcacaaa acattttttt 131221 ttgttttggg tcttttttta tgagccactt atatagcaaa agctactttt ctgtcattcc 131281 attactggaa caaggctgtt gaatttatat taaaaagttc agacaccctc agacacatga 131341 cgccatctgg tcgtgaaatg tactcttggc aaatggagga aaaggaacag gggaagatcc 131401 tctctgcacc cttcacactg gtaaatagtg cccctgagaa gcaacacccg gatgaatggt 131461 gctgtaaaac gtggggtgtg gttacaagtc actaagtggt tataacttat gaattctgaa 131521 aacttgtttt ttggcttatt tttcacttcg ttactggaga ataacactgc aattctgcca 131581 tctctttgcc atttctaagg ccaaagtcag agaaaaaggg aaacctaagc catagtcatg 131641 acctaggtga gaagaaaagg ggcggcgatg ggaaagagaa ttcttcccca taaatggaat 131701 tgtaggaagc acttaggata ccacactcta cccatttgat tttcaggacg aggctattga 131761 ggcctactgc tgttgatctt ggctcaaagc cacagggaga agcactgcgg agctgaggtc 131821 agacagccct ggtgccagcc tccactctct ggggcggtgg gtgtggtggg gacagccctc 131881 actggggcca cccatgagct gacccacagg atgaccccca ctctgctgtg acaggtcaca 131941 tctggctcct tagaactgca atgctgacat gctgagggat gaggtaagtc cccatcctga 132001 tggagctcag tcacagactc accggaaagc cccagtgtag ccgtagtatc tctcgttgct 132061 gttgggcacg cacttattct caccctgctc gtcgccaata cacagagcac agagattaga 132121 tctcgggtca gacccagggg cacagctttg actgaaatat tcatctggag agaaggaaca 132181 cggggagtca gctcttcaaa cctgagtcca cacaagcaac ctttacctaa cagccgatgc 132241 agggtggttt cagttcatta gacttcccag gacagcaatc tagatagaac acactcacca 132301 tcacaaagca acatgttgtc accaacatag gacccaccag aaaagcttca ttcagactgt 132361 aggcacagat ggacacccaa ctaaggctgg ggatgagagc tgtggctgcc tggagggtcc 132421 cgtcatcaca gccttgagct ggggactcag ctcatgaccg tgatggctgt gtgcagcaga 132481 gcctgtgagt tgcctagtcc aggatctgat tttgttttta tcagtaatgg aaaccctgct 132541 ttgtatctgg gtgcttggcc ctttggtata aagactagac ttatcagact ccctggggct 132601 catatggcca tatgggtagc tataggccag tgaaatatca gcaggagtgt tgggcgccag 132661 cttctcagaa acatccttga aagacaattg gtacatgcct tttgcccttt cttctccttc 132721 tctttcttca tcctgcacat agaatgcaga agcagggact ggacttagag atgcaatgtg 132781 ggccatgagg tgaccttgag catgaaagcc acacaaatgg cagagtagcc aaatgattaa 132841 agcccaggtt ccagacccca tattgtcttc ataccagccc taggcaaacc acctctggac 132901 tacatgacac agaaattaac ttctgtcttg tttaagcctc tactatttca ggagttttct 132961 gttccttgca gctgaacctg atctgaattc gttcattgtg tgatttaacc caagaaagaa 133021 taaacaaagg tgacaagaaa gctctgcccc actgagcaaa cgtcacccat tatcagactc 133081 ccactgctgc tggaagagcc acactatgtg tcaacctcag gaaaagctgg gagttcccat 133141 tccatcctgg cagtttccct acagctcaga ggctgccatg gagctggtga ggagcagagc 133201 cacgtgaaag ctgcctgccc cggccaggat caaaaaccca tgcagtggag cccctgccct 133261 aggagacgcc catacaagaa gggagtcaca ttgaggatgt gctacacacc atgccacggg 133321 gcccacagca ggcagggtgt ggctgatgct gactaggatg agtgtggggt gtggtgggga 133381 gagaaaactg cagaagcagg tggagccagg ctcttgaggt cttattcagg ctccgttgca 133441 gtgtagagta agcgtcagtt ttgcttagta acaggagtca cctttcatga ggcaggcaga 133501 catctttccc caagctggga agccagagtt taagaggaat ttaggtctgg agctccaaga 133561 ggtaaaaagc atttgcacat cttggaactt gcatttattc ttagggtgca gcgaaatagg 133621 cagatattcc aatctttaat cttggggtgg ggtgaatggg gcatgggaag tgctgtgcag 133681 ggaaaccccc agtgcaccca cgcctccagg gggcagccac agggagaatt tccttatgct 133741 ggaagaggcc tgcaggccac tatcagcctg caaatcccct cccctccctt ccctaaggtt 133801 ccacagcaca atatgcctac cctccagggt ggcccaccca ccgcaccttt ggaactcctt 133861 accaaatttg caggagcccg tctggttgaa gagcaggccc atggggatat tccagcctgc 133921 agtcctgtcc acggcggtgt ggcaggactt cttgcctttc acagagttcc aggtaaggct 133981 agtgtctgat ctcctaacca ccgccacagc aagatatcct ggcataacag atgacagaaa 134041 aacaagtctt aacctccagg aggcctggca catggattcc agtggagctg tctacagccc 134101 aggccaaaac aggccaagaa gcaacaccag gcaatgattc cctcaaagaa ctggcctttt 134161 taggtagacc gagaaagcat aagctgctgc cttatgttaa ggtgagattg atgaaataaa 134221 acagtaagaa aagctgatta ttttagtgat tacaggggac tgtcttcaac cagccacaca 134281 atgtccctga gttacaaacc agcaatgcat ctctcagtgt aagcttctac agcaacaaac 134341 actataaaca acaagagaga ccccaacagt gcataaatca ccaaccacag tgtgcatcag 134401 gcaagagcac caacatccag ccagctaacg gctgtgtggg tacaggggca catgtcccca 134461 gggactgccc tgagctgagt ctgaacccac cctgcactgg ttgaactcaa catggttgcc 134521 gttgtcctcc tgagagaatg catctgacag acacccacca agggcaagtc ttttctgaaa 134581 ctgagcaagc accagctctg gtgggcagga ggagtggtgc acagagcact gggacacgag 134641 tcccaggtca cgaggacccg gggtcaagac caggatctac cacagtatta cctatggctg 134701 tgagtgagat cctgggcact tggggactct cggtgccact gtttcctcat ccccatgagg 134761 tggggaagta gcacccccca ttccatgacc atgacaaaat gagggactat atggatgttc 134821 tttgccaagt gtgaaggtca atataaacat taattagaac tattcctctg tgaattattt 134881 gcacccttaa aattattgct cctagaagcc ctatagcttc tagggctgca attctttctg 134941 ttttttttac agttcctgcc acttcctctt ccagcaacaa gaacttatcc ttgaccctga 135001 aagtggctaa tgccaactca ccttccacag gtctatccac acagttagga tcagggtcac 135061 tgctttgttg ggattctgaa agaataaaga caagccagac atcattatcc attcagatgt 135121 agtgagaagc cacaaactct taaatctcaa tgatgcagaa tcaaatccaa agagaccgtc 135181 ccagcagttc catgcaggag aaatgcgtct atatgttcaa caaaagacat ggcacagaga EPI-109 1170

135241 ttcacagctg cattattcac cacagccacc aactggaaac tactcaaatg cccatccaca 135301 ctcaaatgat gaataatcac agtagactca cacagcgacg agactgaaca gtctacaact 135361 acacacttag gtggatgaaa agcataacga tgagcaagag aaaccagaca taaaaaaaca 135421 catgctgtgt aattccttta acatgaagtt taaaacatag gcaaacttag atctgcgacc 135481 ttagaagcca ggagagaggc ttcccttgca ggagtaaggg ggcgggggac aggaggacat 135541 aaggggcttc tgaaacttgc agtgtttgtt ctgggcccga gagcatggac tgtacagtgt 135601 gtgaagtgcc atgagttgta catttatgtg cacttttctg tttgtatgtt ataattcact 135661 gagatcttct ggaaaattaa gaagataaaa ccaacctgtc ccttgttaat tctcaacaca 135721 ataggctttg tgggtaacac ggcccctttc atttcttctt tccctgattc tcccttttga 135781 atgtatctgt tcatcataat gtttcacctg cattcaccga atgggattac tcatagcccc 135841 actcccatga cccagaggga atataccaga ggatgctaac tccacttact gtagttctct 135901 gccaggacag gcaccaaacc acatttgcct gcagtgtaca catatcctcc atccaaactc 135961 atggcatcag cttctccttt ctgcaaagac agagcagatc tccagcacca cagtgaggct 136021 gcatcccgtc ctgcctgtct atatagctct ctgagagaat ggttttctgt caggtgacca 136081 gtgaaacagc agaaagagat ggactattca aactgagcag ccagaggaaa caccgtgtgc 136141 accactaatt ctctcccagc cctgcctact ttctgggctg tcaattcaac tggaaagacc 136201 aggcacaggt tgcactaatc ctctgtcctc tgagcaaaac cttttctgtg tccctggcac 136261 tttggggaca ccttcctgga gcagtctcac tgactgagga cacagatggg aacagctggc 136321 ctcatctaat ctgaactcat tagcactcca ctccaagcgc tacacagaag ttgtccaaca 136381 cataagctga agtcgtcata ttggcccacc accagaatga acaagtccag gctacaacac 136441 aggatcatgg actcatcagt agtatgaaac ttcctctttg acccagtaat atttttacaa 136501 ctatattaaa aatagagaag tggacaaaga tttctactca agaatgctca ccacagggtt 136561 attgataata gcaaagtaag ggacaaagag gaatgggggc atgactaaac tgagccatat 136621 tcacataaaa gatatcctgg aagcatgttt aaaaaatgtt ttcgtccgag tgctgtggct 136681 cacacccgta atcccagcac tttgggaggc cgaagcagga agattgcttg agcccaggag 136741 ttcgagacga gcctgggcaa caaagcgaga ccctgtcgct acaataataa taataataat 136801 tatgcaggtg tggtggcgta tgcctgtagc cccagctact tgggaagctg agatgggagg 136861 atcacttgag cccaagagtt ccaggctgca gtgagatgtg gtcgcaccac tgcactccag 136921 cctgggtgac agatcaagaa tctgtctctt aaaaaaaaaa aaattaatgc tttccaagag 136981 taaatattca tgtggaagaa tgcccattat acgctgttta gtgaaaaggg cttaaaaacg 137041 acatactgca acacttcatt attgttgcat gcatatctgc agatgtgcag agaaatactg 137101 gaatggagaa ttagccagac tttaaccatg tctgtccctc tgtgtgagat cacaggtggt 137161 ttggggggtt tgttgttgtt ttgttttaac ataatacctt tccatatttt ccaaattcct 137221 tataataatc ctgagttgtt cttataacca gaggagtggg aaacccacag taaactgctt 137281 tttgaaacta aaatgctttc tggccctgag cacacctctc caggcatccc tgcctcaccc 137341 aggcccccgt ggcctctttg actgttgact tcactttaag cagatgccca ggccctaggt 137401 cttccaccgg gcccaccgcc cgcccctgtg atggagctcc ctaccagcac cagggcgatg 137461 cagtcctctg tggtggaggc cgaggagcag gtcacgctgc cttcgctcaa gccactccac 137521 tggttacact tgcgcagctc ctgctcgccc accgcacacc acacgacccg cgcacgccgg 137581 gcagccactt cctcctcacc tgccagaggg aagaccgcag gtggctgggc aacctgagct 137641 ttgccaggtt gtccaacctc cccagagcca gggtcctgcc cagactctcc ctggaacagg 137701 agctacagta catgtgtgga catgtggacc cataccctct cctcctccac ttctcagctc 137761 caagcccctt cttcaggtcc acagagctcc ctgtgtttcc cacttctgtt cctttggaga 137821 agttccctgg cttctaatct atccattaat ctttagagtc aggaggcgcc tattgtctct 137881 gtctctgagg ataaacgctc catgacccag agaccagtga cagtcccaag agatggccta 137941 ggggaccttg agcccaaccc tgacttcccc taacgcctgc aatcaccacc aataactacg 138001 gtgcagcctc tgggttcccc cagactccca cccccagccc cccagtagag aaggagccat 138061 agctgagttc ccccaccatg gtgtccccaa ctaagttcaa ggtctgggcc tgggaagtgt 138121 gggtaaatcc aggcccccgg attcatccag gaggggtcct ggctatcttt gttcatgttc 138181 atgtttctca cttaatagga ggcaaactga tttttctgcc aggcctgggg agcctgacgt 138241 gcactgatca ggtggccaga ctattctttt agagacacct gacctaatcc acagaagaca 138301 ctcacacctg catcaaacct ccacgatgac cccacagtgt ctgggaaaag gagtgaccgc 138361 cacaaagtag ggccacctgc tgggaagtag aagaccacac caggcggacc tcaggaccct 138421 cctgggctca ctcacttttc ctcaagttct ggatggcagt gaagtagccg gagccaaggt 138481 acagcccaga atctatcctc gggggcaccc tcgaaaaccc aatggcagag tccttgaaca 138541 gcagatcttt ctgcccacta ggggagccaa agagctggaa tttcggtgac ttgtcctttc 138601 caaacttttc ctaattaaga aaaaatagaa ttatggtgtc aatggtaaat agggaggaaa 138661 caaaaaaatg atgttaaaaa agagtatctg gagctttggg atcattctaa ctgagagcag 138721 gagcctcggt tgagaccctc ctgcagaggg acttgtgcca tctcggagac ccaagctcag 138781 ctatggctca ttctttgaag agttgctgag gtccaagcac cttagggccc tgagaagatt 138841 gcatcgacca ccccctgctt ctgctcccat cataagacgc tgtcagcccg tgtgacagaa 138901 gagtttcatt gcttctgctg tccacagtac agcctgggca agcagcccaa tgcattagtg 138961 tgctatcctg cagcaaagct acaggacttc tggagtggca gaagtcaggg aagtaagaaa 139021 ccttgctccc tgccccccat atccaagcaa gtggggagga ccgtgggtga agatacctgt 139081 gcctggcgga gaagattcca gatggcatcc tccttgccat tcacacttcg tgccacaacg 139141 gcatgagaag ggacccgggc cagatggcag tctttgaact tgtccactgg cttccgagtg 139201 ttgtctgggc agagtaactc atactcgtcc ctttcagcct cgtctgacag gtcctctgca 139261 gggaaggtga ggtgggaggg agtctagata agccgactcc agcagtaacc tcgagctata 139321 gttccccttc tccctataga attttgagct tggggagata gctgacaaaa ctgagggtca 139381 gaaaggcagg ggtttgctcc agaacactca gaaaggtaaa ggtagtgccc caaaagcctc 139441 agggggcagc cgaggtgtga tcctcatcct aaatcactta ggccaccctg gggttcccgt 139501 gcagctgctg cctggcaggc cagagaggcc aaaccagacc cgtctgtttc tgcggcatct 139561 ctgcctggaa aagtcacttt gcagagacaa gctcaggggg ccaccaaggg ttgctccctt 139621 actcacatct ctgggaagaa taaaaatgac aaaaatgtta acaaggcagg gaataaggca 139681 ggaaggtgag acactttcca acactgagta tatcaaaaga aggggaagaa tggttttatg EPI-109 1171

139741 aatgagttca ggcaaatgtg gaatatcata tataagttgc ttcagaatgt gtaaagtgaa 139801 aaaaatcttg cccgagtcat tttatgagat tagtacaacc ttgatgtcaa aatcagaaaa 139861 agtataggag ggaagaatta aaagtttatt ttacttacga acataaatgc aaaatttgta 139921 aataacgtac taactaactc aatctcacag agtatttaaa aagctaatag attggaatga 139981 aggtttacca gtgtattcca ttaacaaaag aatggctgaa catcaaaaaa actaaagtaa 140041 tctgcattta atggcagaaa accatgagat cgtcttcatc ttaatagatg cagaacgatt 140101 gtttatgtgt tcaacatcta tttgtgtgtg gttttttttt cagcctcaga aaaatagtaa 140161 tagatagaat cggtaaagtt tttttgtttg ttttgagacg gagtctcact ctgttgccca 140221 gcctggaatg cagtggtgcg atctcagctc actgcatcct ccatctcctg gagtcaagag 140281 attctcttgc ctcagcctcc caagtagctg ggaccacaag cgcacgccac caggcccagc 140341 taatttttgt atttttaata gagatggggt ttcaccatgt tggccaggct ggtctcgaac 140401 tcctgacctc atgtgatcca cccgcctcag tctcccaaag tgctgggatt acaggggtga 140461 gacaccacgc ctggccataa gttattggct tgataaatgc cattaatcta cagcaaaaac 140521 cttactaaaa gaagaaaatg tagacattca ccgcaaaatc aggaacaagg caaggatgcc 140581 cactgttaca atgccagcac aattctagat atccagatca cacaatttac aaaagaaatg 140641 tgagatataa acactggaag gaaaaagaca cactcttatt taaaaagatg atatcgtcat 140701 ctacaaaaaa ccaatgaaac caacagaaac taataaaact actcagagga gtaacaagtt 140761 ataagagcaa cctacaaaaa tcagatgtta tcctcattaa caataaccaa atagaaacca 140821 atatggacta taagatgtta caatagcaac taaaaccatt aagtagctaa taattagcct 140881 cccacaaaga cacatcagac ccacaaagga aaaattttag ttctatcaaa gaaactaaaa 140941 agaggtgtga tcaaatgggg gagatttagc atcaccatgg actggacaac ttaatgttat 141001 aaatatgctg atttttcatg gaacaattta aattcagtac aattcgaatc aaaattaaag 141061 tatgattttt tccagaaatt caacaaaata attctgaagt tttagctgag tatatttgaa 141121 aaggaataat aaagtgagag gggagaggga gctctctctc attctctctc tcttcctctc 141181 actggctctc tctctttctc tccaccagat agtaagaccc attggtaagc cacagtaaca 141241 aaagcagaaa aaatgcaaat acaccaatga aataaaatag ctcagaaact ggtccacttg 141301 gatatataca aacttggtgt agaattggct tcacatatgg cagaaaaaat atactttttt 141361 tattgtaagg taaattgcct cactgtaaag gggataaaat gctaaagcca aatctatatc 141421 tgactttcta ggtagagcac atataaatag atgaggaagg ggatcttcaa atcttatttt 141481 aggaaataat tatgatttgg gtgtgaagaa gggcatcttt gaaatatctc aaaactacaa 141541 accaacaagg tgaggcttgt ggatttgacc ttatcaatat caaggatttt tgatcaacag 141601 agactaccgt tgtcagattt ttgactgaga agaggtttta ctaaagttta aaatcagcaa 141661 tagtttgata cctagataga aggaacttct gtccttgaat caaaatcatg cagaaacaag 141721 gtgtgaaact caatttaaaa agtagtcaaa tgtcacaaaa taagaaaggg aagcccaaac 141781 ggctagcaaa tatgttgaaa tgatcaaact caccagctgt cagagaaatg aaaattaaaa 141841 ataaaacgaa ctatctattg cattacaacc atcattcgga caaaaagtat gaaagtcaaa 141901 aatacttcta actgaagttg tggggaaatt agaacacttg cagagtgtca ttccagacag 141961 cagcttggtg atcctgggtg catgtggggt ctgtctctgg tggccctggg tgcatgtgga 142021 ggtctgtttc tggtggcctc tgatgaatgc ggggtctgtc tctgatggtc ctaggtgaat 142081 gtgggtgttg tctctttctc tggtggtcct gggtggatgt ggggtgtgtc tctgatggtc 142141 ctgagtgaat gtgggtgtct gtcactttct ctagtggccc tgggtggaat atagtagccc 142201 tgtctctatt ggtcttgcat gaaatgtagt gagcttatgt ccactagtcc tgggtgcagt 142261 gtgtttagcc tctacatact catcaactgc tttattataa gtccaggagg gacgctgtcc 142321 agcaggtaag taaggaacac aggtgaaggt atcagtcgtg tggctgcatg tggtagagga 142381 aaagagagca caacctctgt ccatcactat ggtgacagag aagtaaaagg tggatgtatt 142441 ccacggaaca ctcctcaact gttaggaccc ctgagctaga catgtataca acaataccga 142501 taaacctcta aaacaaaatg ctgagcagaa aacccaagta gcaggatttc taatgctcac 142561 taaaacctct atgaacccag aaaccggaaa cacaaaccag cacaatctgt tctgcatgag 142621 cacatgtgtc ttggaggact ggaggacgca ttgccaagca cctaggcatg ggtgtctatg 142681 aggggaagag aaaggcagta ggcacaggag gtttgaagaa aactgatcat ttaaaatatg 142741 aaagatcata aaatcagagc tgtgccctgt aggaatcttg aaaatggtct gccatgaact 142801 taggaatcta attagctcaa aggtcagagt catgatcaag taagataaaa ggggtcagta 142861 cccacggctc attaccctgc tcttaccaaa cactgtgctc tctctgataa aagccacgtc 142921 tccagccccg tctctcagac acctgtgaaa agagaaacca tcaggggtaa gcacaggcag 142981 ccctccccag cccctccctg tggaacagta gccctggcac tcagcatcta tgggtttcta 143041 ctccctgcag ggcagggctc tgaagctt

(2) INFORMATION FOR SEQ ID NO: 26:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 5133 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:26: 1 cctctttcac cctgtctagg ttgccagcaa atcccacggg cctcctgacg ctgcccctgg

61 ggccacaggt ccctcgagtg ctggaaggat gaaggattcc tgcatcactg tgatggccat 121 ggcgctgctg tctgggttct ttttcttcgc gccggcctcg agctacaacc tggacgtgcg 181 gggcgcgcgg agcttctccc caccgcgcgc cgggaggcac tttggatacc gcgtcctgca 241 ggtcggaaac ggggtcatcg tgggagctcc aggggagggg aacagcacag gaagcctcta 301 tcagtgccag tcgggcacag gacactgcct gccagtcacc ctgagaggtt ccaactatac 361 ctccaagtac ttgggaatga ccttggcaac agaccccaca gatggaagca ttttggcctg 421 tgaccctggg ctgtctcgaa cgtgtgacca gaacacctat ctgagtggcc tgtgttacct 481 cttccgccag aatctgcagg gtcccatgct gcaggggcgc cctggttttc aggaatgtat EPI-109 1 172

541 caagggcaac gtagacctgg tatttctgtt tgatggttcg atgagcttgc agccagatga

601 atttcagaaa at ctggact tcatgaagga tgtgatgaag aaactcagca acacttcgta

661 ccagtttgct gctgttcagt tttccacaag ctacaaaaca gaatttgatt tctcagatta

721 tgttaaatgg aaggaccctg atgctctgct gaagcatgta aagcacatgt tgctgttgac

781 caataccttt ggtgccatca attatgtcgc gacagaggtg ttccgggagg agctgggggc

841 ccggccagat gccaccaaag tgcttatcat catcacggat ggggaggcca ctgacagtgg

901 caacatcgat gcggccaaag acatcatccg ctacatcatc gggattggaa agcattttca

961 gaccaaggag agtcaggaga ccctccacaa atttgcatca aaacccgcga gcgagtttgt

1021 gaaaattctg gacacatttg agaagctgaa agatctattc actgagctgc agaagaagat

1081 ctatgtcatt gagggcacaa gcaaacagga cctgacttcc ttcaacatgg agctgtcctc

1141 cagcggcatc agtgctgacc tcagcagggg ccatgcagtc gtgggggcag taggagccaa

1201 ggactgggct gggggctttc ttgacctgaa ggcagacctg caggatgaca catttattgg

1261 gaatgaacca ttgacaccag aagtgagagc aggctatttg ggttacaccg tgacctggct

1321 gccctcccgg caaaagactt cgttgctggc ctcgggagcc cctcgatacc agcacatggg

1381 ccgagtgctg ctgttccaag agccacaggg cggaggacac tggagccagg tccagacaat

1441 ccatgggacc cagattggct cttatttcgg tggggagctg tgtggcgtcg acgtggacca

1501 agatggggag acagagctgc tgctgattgg tgccccactg ttctatgggg agcagagagg

1561 aggccgggtg tttatctacc agagaagaca gttggggttt gaagaagtct cagagctgca

1621 gggggacccc ggctacccac tcgggcggtt tggagaagcc atcactgctc tgacagacat

1681 caacggcgat gggctggtag acgtggctgt gggggcccct ctggaggagc agggggctgt

1741 gtacatcttc aatgggaggc acggggggct tagtccccag ccaagtcagc ggatagaagg

1801 gacccaagtg ctctcaggaa ttcagtggtt tggacgctcc atccatgggg tgaaggacct

1861 tgaaggggat ggcttggcag atgtggctgt gggggctgag agccagatga tcgtgctgag

1921 ctcccggccc gtggtggata tggtcaccct gatgtccttc tctccagctg agatcccagt

1981 gcatgaagtg gagtgctcct attcaaccag taacaagatg aaagaaggag ttaatatcac

2041 aatctgtttc cagatcaagt ctctctaccc ccagttccaa ggccgcctgg ttgccaatct

2101 cacttacact ctgcagctgg atggccaccg gaccagaaga cgggggttgt tcccaggagg

2161 gagacatgaa ctcagaagga atatagctgt caccaccagc atgtcatgca ctgacttctc

2221 atttcatttc ccggtatgtg ttcaagacct catctccccc atcaatgttt ccctgaattt

2281 ctctctttgg gaggaggaag ggacaccgag ggaccaaagg gcgcagggca aggacatacc

2341 gcccatcctg agaccctccc tgcactcgga aacctgggag atcccttttg agaagaactg

2401 tggggaggac aagaagtgtg aggcaaactt gagagtgtcc ttctctcctg caagatccag

2461 agccctgcgt ctaactgctt ttgccagcct ctctgtggag ctgagcctga gtaacttgga

2521 agaagatgct tactgggtcc agctggacct gcacttcccc ccgggactct ccttccgcaa

2581 ggtggagatg ctgaagcccc atagccagat acctgtgagc tgcgaggagc ttcctgaaga

2641 gtccaggctt ctgtccaggg cattatcttg caatgtgagc tctcccatct tcaaagcagg

2701 ccactcggtt gctctgcaga tgatgtttaa tacactggta aacagctcct ggggggactc

2761 ggttgaattg cacgccaatg tgacctgtaa caatgaggac tcagacctcc tggaggacaa

2821 ctcagccact accatcatcc ccatcctgta ccccatcaac atcctcatcc aggaccaaga

2881 agactccaca ctctatgtca gtttcacccc caaaggcccc aagatccacc aagtcaagca

2941 catgtaccag gtgaggatcc agccttccat ccacgaccac aacataccca ccctggaggc

3001 tgtggttggg gtgccacagc ctcccagcga ggggcccatc acacaccagt ggagcgtgca

3061 gatggagcct cccgtgccct gccactatga ggatctggag aggctcccgg atgcagctga

3121 gccttgtctc cccggagccc tgttccgctg ccctgttgtc ttcaggcagg agatcctcgt

3181 ccaagtgatc gggactctgg agctggtggg agagatcgag gcctcttcca tgttcagcct

3241 ctgcagctcc ctctccatct ccttcaacag cagcaagcat ttccacctct atggcagcaa

3301 cgcctccctg gcccaggttg tcatgaaggt tgacgtggtg tatgagaagc agatgctcta

3361 cctctacgtg ctgagcggca tcggggggct gctgctgctg ctgctcattt tcatagtgct

3421 gtacaaggtt ggtttcttca aacggaacct gaaggagaag atggaggctg gcagaggtgt

3481 cccgaatgga atccctgcag aagactctga gcagctggca tctgggcaag aggctgggga

3541 tcccggctgc ctgaagcccc tccatgagaa ggactctgag agtggtggtg gcaaggactg

3601 agtccaggcc tgtgaggtgc agagtgccca gaactggact caggatgccc agggccactc

3661 tgcctctgcc tgcattctgc cgtgtgccct cgggcgagtc actgcctctc cctggccctc

3721 agtttcccta tctcgaacat ggaactcatt cctgaatgtc tcctttgcag gctcataggg

3781 aagacctgct gagggaccag ccaagagggc tgcaaaagtg agggcttgtc attaccagac

3841 ggttcaccag cctctcttgg ttccttcctt ggaagagaat gtctgatcta aatgtggaga

3901 aactgtagtc tcaggaccta gggatgttct ggccctcacc cctgccctgg gatgtccaca

3961 gatgcctcca ccccccagaa cctgtccttg cacactcccc tgcactggag tccagtctct

4021 tctgctggca gaaagcaaat gtgacctgtg tcactacgtg actgtggcac acgccttgtt

4081 cttggccaaa gaccaaattc cttggcatgc cttccagcac cctgcaaaat gagaccctcg

4141 tggccttccc cagcctcttc tagagccgtg atgcctccct gttgaagctc tggtgacacc

4201 agcctttctc ccaggccagg ctccttcctg tcttcctgca ttcacccaga cagctccctc

4261 tgcctgaacc ttccatctcg cccacccctc cttccttgac cagcagatcc cagctcacgt

4321 cacacacttg gttgggtcαt cacatctttc acacttccac caccctgcac tactccctca

4381 aagcacacgt catgtttctt catccggcag cctggatgtt ttttccctgt ttaatgattg

4441 acgtacttag cagctatctc tcagtgaact gtgagggtaa aggctatact tgtcttgttc

4501 accttgggat gacgccgcat gatatgtcag ggcgtgggac atctagtagg tgcttgacat

4561 aatttcactg aattaatgac agagccagtg ggaagataca gaaaaagagg gccggggctg

4621 ggcgcggtgg ttcacgcctg taatcccagc actttgggag gccaaggagg gtggatcacc 4681 tgaggtcagg agttagaσgc cagcctggcg aaaccccatc tctactaaaa atacaaaatc 4741 caggcgtggt ggcacacacc tgtagtccca gctactcagg aggttgaggt aggagaattg 4801 cttgaacctg ggaggtggag gttgcagtga gccaagattg cgccattgca ctccagcctg 4861 ggcaacacag cgagactccg tctcaaggaa aaaataaaaa taaaaagcgg gcacgggccc 4921 ggacatcccc acccttggag gctgtcttct caggctctgc cctgccctag ctccacaccc 4981 tctcccagga cccatcacgc ctgtgcagtg gcccccacag aaagactgag ctcaaggtgg 5041 gaaccacgtc tgctaacttg gagccccagt gccaagcaca gtgcctgcat gtatttatcc 5101 aataaatgtg aaattctgtc caaaaaaaaa aaa

(2) INFORMATION FOR SEQ ID NO: 27: ⁽i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1388 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:27: ggatccagaa gggtcattca atcagttctc agtcttatca ggtctaagtt cctttcttat

61 caggtcctaa aggcctaatc ttatcattgt gacaaagata actgtagagt ctgttaaact

121 ttttttttaa taacatgaag attatgattt atagctgaat ttctcccttt tattccaatt

181 caacaatttt catggctttt tgtgtttgtt ttgttctgga catatttaca gaaaattacc

241 tgaagagttc caacctgagg cctcctcatg gatgggtcaa acgtgacatc atttgttgtt

301 gaggaaccca cgaacatctc aactggcagg aacgcctcag tcgggaatgc acatcggcaa

361 atccccatcg tgcactgggt cattatgagc atctccccag tggggtttgt tgagaatggg

421 attctcctct ggttcctgtg cttccggatg agaagaaatc ccttcactgt ctacatcacc

481 cacctgtcta tcgcagacat ctcactgctc ttctgtattt tcatcttgtc tatcgactat

541 gctttagatt atgagctttc ttctggccat tactacacaa ttgtcacatt atcagtgact

601 tttctgtttg gctacaacac gggcctctat ctgctgacgg ccattagtgt ggagaggtgc

661 ctgtcagtcc tttaccccat ctggtaccga tgccatcgcc ccaagtacca gtcggcattg

721 gtctgtgccc ttctgtgggc tctttcttgc ttggtgacca ccatggagta tgtcatgtgc

781 atcgacagag aagaagagag tcactctcgg aatgactgcc gagcagtcat catctttata

841 gccatcctga gcttcctggt cttcacgccc ctcatgctgg tgtccagcac catcttggtc

901 gtgaagatcc ggaagaacac gtgggcttcc cattcctcca agctttacat agtcatcatg

961 gtcaccatca ttatattcct catcttcgct atgcccatga gactccttta cctgctgtac

1021 tatgagtatt ggtcgacctt tgggaaccta caccacattt ccctgctctt ctccacaatc

1081 aacagtagcg ccaacccttt catttacttc tttgtgggaa gcagtaagaa gaagagattc

1141 aaggagtcct taaaagttgt tctgaccagg gctttcaaag atgaaatgca acctcggcgc

1201 cagaaagaca attgtaatac ggtcacagtt gagactgtcg tctaagaact gtgagggaag

1261 ttgtggataa aaatggtgga acacaggtca tttttagttt gtgcttggaa tatgacttaa

1321 gtatctccta aatgtgatac agaagaacat ctcatcccat atgcatgaga tactaattaa

1381 tgatgaaa

(2) INFORMATION FOR SEQ ID NO:28: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 393 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 28: gagcagtgcc cagcttgtcg cagatattga agccgtgtaa aataaatgcc tttgattgtt

61 cacactttaa gcaatattgg tacaatatta aacccattgt cccaggcact ccctctcctt

121 actgcttatg gcacttcatg tattaaaaaa tgacagtggc agcattgccc agacatgcgt

181 tttgtcatca agtcttaatg cagtccacct ggtccctcag gcaaatgaat ggaggcacag

241 aagatgaaat gattttcaaa atgccattag gaaagctcag gccagaactg gaaatgggtc

301 ccgcacaggg cactcggcca ctcttgcctg gccatctcct ttttggcact aagcacacaa

361 tgatatagaa tgaatggtta tcactgggga tec

(2) INFORMATION FOR SEQ ID NO:29: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1388 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 29: ggatccagaa gggtcattca atcagttctc agtcttatca ggtctaagtt cctttcttat

61 caggtcctaa aggcctaatc ttatcattgt gacaaagata actgtagagt ctgttaaact

121 ttttttttaa taacatgaac attatgattt atagctgaat ttctcccttt tattccaatt

181 caacaatttt catggctttt tgtgtttgtt ttgttctgga catatttaca gaaaattacc

241 tgaagagttc caacctgagg cctcctcatg gatgggtcaa acgtgacatc atttgttgtt

301 gaggaaccca cgaacatctc aactggcagg aacgcctcag tcgggaatgc acatcggcaa EPI-109 1174

361 atccccatcg tgcactgggt cattatgagc atctccccag tggggtttgt tgagaatggg

421 attctcctct ggttcctgtg cttccggatg agaagaaatc ccttcactgt ctacatcacc

481 cacctgtcta tcgcagacat ctcactgctc ttctgtattt tcatcttgtc tatcgactat

541 gctttagatt atgagctt c ttctggccat tactacacaa ttgtcacatt atcagtgact

601 tttctgtttg gctacaacac gggcctctat ctgctgacgg ccattagtgt ggagaggtgc

661 ctgtcagtcc tttaccccat ctggtaccga tgccatcgcc ccaagtacca gtcggcattg

721 gtctgtgccc ttctgtgggc tctttcttgc ttggtgacca ccatggagta tgtcatgtgc

781 atcgacagag aagaagagag tcactctcgg aatgactgcc gagcagtcat catctttata

841 gccatcctga gcttcctggt cttcacgccc ctcatgctgg tgtccagcac catcttggtc

901 gtgaagatcc ggaagaacac gtgggcttcc cattcctcca agctttacat agtcatcatg

961 gtcaccatca ttatattcct catcttcgct atgcccatga gactccttta cctgctgtac

1021 tatgagtatt ggtcgacctt tgggaaceta caecacattt ccetgetctt ctccacaate

1081 aacagtagcg ccaacccttt catttacttc tttgtgggaa gcagtaagaa gaagagattc

1141 aaggagtcct taaaagttgt tctgaccagg gctttcaaag atgaaatgca acctcggcgc

1201 cagaaagaca attgtaatac ggtcaeagtt gagactgtcg tctaagaact gtgagggaag

1261 ttgtggataa aaatggtgga acacaggtca tttttagttt gtgcttggaa tatgacttaa

1321 gtatctceta aatgtgatac agaagaacat etcatcceat atgcatgaga taetaattaa

1381 tgatgaaa

(2) INFORMATION FOR SEQ ID NO: 30: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3169 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 30: ggatccagaa gggtcattca atcagttctc agtcttatca ggtctaagtt cctttcttat

61 caggtcctaa aggcctaatc ttatcattgt gacaaagata actgtagagt ctgttaaact

121 ttttttttaa taacatgaag attatgattt atagctgaat ttctcccttt tattccaatt 181 caacaatttt catggctttt tgtgtttgtt ttgttctgga catatttaca gaaaattacc 241 tgaagagttc caacctgagg cctcctcatg gatgggtcaa acgtgacatc atttgttgtt 301 gaggaaccca cgaacatctc aactggcagg aacgcctcag tcgggaatgc acatcggcaa 361 atccccatcg tgcactgggt cattatgagc atctccccag tggggtttgt tgagaatggg 421 attctcctct ggttcctgtg cttccggatg agaagaaatc ccttcactgt ctacatcacc 481 cacctgtcta tcgcagacat ctcactgctc ttctgtattt tcatcttgtc tatcgactat 541 gctttagatt atgagctttc ttctggccat tactacacaa ttgtcacatt atcagtgact 601 tttctgtttg gctacaacac gggcctctat ctgctgacgg ccattagtgt ggagaggtgc 661 ctgtcagtcc tttaccccat ctggtaccga tgccatcgcc ccaagtacca gtcggcattg 721 gtctgtgccc ttctgtgggc tctttcttgc ttggtgacca ccatggagta tgtcatgtgc 781 atcgacagag aagaagagag tcactctcgg aatgactgcc gagcagtcat catctttata

841 gccatcctga gcttcctggt cttcacgccc ctcatgctgg tgtccagcac catcttggtc 901 gtgaagatcc ggaagaacac gtgggcttcc cattcctcca agctttacat agtcatcatg 961 gtcaccatca ttatattcct catcttcgct atgcccatga gactccttta cctgctgtac 1021 tatgagtatt ggtcgacctt tgggaaceta caecacattt ccetgetctt ctccacaate 1081 aacagtagcg ccaacccttt catttacttc tttgtgggaa gcagtaagaa gaagagattc 1141 aaggagtcct taaaagttgt tctgaccagg gctttcaaag atgaaatgca acctcggcgc 1201 cagaaagaca attgtaatac ggtcaeagtt gagactgtcg tctaagaact gtgagggaag 1261 ttgtggataa aaatggtgga acacaggtca tttttagttt gtgcttggaa tatgacttaa 1321 gtatctceta aatgtgatac agaagaacat etcatcceat atgcatgaga taetaattaa 1381 tgatgaaa gagcagtgcc cagcttgtcg cagatattga agccgtgtaa aataaatgcc tttgattgtt

61 cacactttaa gcaatattgg tacaatatta aacccattgt cccaggcact ccctctcctt

121 actgcttatg gcacttcatg tattaaaaaa tgacagtggc agcattgccc agacatgcgt

181 tttgtcatca agtcttaatg cagtccacct ggtccctcag gcaaatgaat ggaggcacag

241 aagatgaaat gattttcaaa atgccattag gaaagctcag gccagaactg gaaatgggtc

301 ccgcacaggg cactcggcca ctcttgcctg gccatctcct ttttggcact aagcacacaa

361 tgatatagaa tgaatggtta tcactgggga tec ggatccagaa gggtcattca atcagttctc agtcttatca ggtctaagtt cctttcttat

61 caggtcctaa aggcctaatc ttatcattgt gacaaagata actgtagagt ctgttaaact 121 ttttttttaa taacatgaag attatgattt atagctgaat ttctcccttt tattccaatt 181 caacaatttt catggctttt tgtgtttgtt ttgttctgga catatttaca gaaaattacc 241 tgaagagttc caacctgagg cctcctcatg gatgggtcaa acgtgacatc atttgttgtt 301 gaggaaccca cgaacatctc aactggcagg aacgcctcag tcgggaatgc acatcggcaa 361 atccccatcg tgcactgggt cattatgagc atctccccag tggggtttgt tgagaatggg 421 attctcctct ggttcctgtg cttccggatg agaagaaatc ccttcactgt ctacatcacc 481 cacctgtcta tcgcagacat ctcactgctc ttctgtattt tcatcttgtc tatcgactat 541 gctttagatt atgagctttc ttctggccat tactacacaa ttgtcacatt atcagtgact 601 tttctgtttg gctacaacac gggcctctat ctgctgacgg ccattagtgt ggagaggtgc 661 ctgtcagtcc tttaccccat ctggtaccga tgccatcgcc ccaagtacca gtcggcattg EPI-109 1175

"21 gtctgtgccc ttctgtgggc tctttcttgc ttggtgacca ccatggagta tgtcatgtgc

781 atcgacagag aagaagagag tcactctcgg aatgactgcc gagcagtcat catctttata

841 gccatcctga gcttcctggt cttcacgccc ctcatgctgg tgtccagcac catcttggtc

901 gtgaagatcc ggaagaacac gtgggcttcc cattcctcca agctttacat agtcatcatg

961 gtcaccatca ttatattcct catcttcgct atgcccatga gactccttta cctgctgtac

1021 tatgagtatt ggtcgacctt tgggaaceta caecacattt ccetgetctt ctccacaate

1081 aacagtagcg ccaacccttt catttacttc tttgtgggaa gcagtaagaa gaagagattc

1141 aaggagtcct taaaagttgt tctgaccagg gctttcaaag atgaaatgca acctcggcgc

1201 cagaaagaca attgtaatac ggtcaeagtt gagactgtcg tctaagaact gtgagggaag

1261 ttgtggataa aaatggtgga acacaggtca tttttagttt gtgcttggaa tatgacttaa

1321 gtatctceta aatgtgatac agaagaacat etcatcceat atgcatgaga taetaattaa

1381 tgatgaaa

(2) INFORMATION FOR SEQ ID NO: 31: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3585 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 31: gggcccagag aaagagctgt ccccggggcc ttggggacag ggtgacagcc acccagagat

61 catggagaag gggacgtaag gaagacctca cagaggagtc atcctgcgac tgtgttggtt

121 gggtccttca ggaagcagag tcccaggagt tggaagcata agaggaatac tgcgggcaat

181 gcctgagaaa gataacaggg accgggagca ggagtgagtt gggcagggga aggatcaggc

241 ccacaatgcc aggctcacac ctgcagagga gggaagaaga agaagggcct cacatcagcc

301 cagcggggga tgttacgccc acagacgccc cggggctcag ttactgtcta agtgttagaa

361 ataaattttc ggtgccacaa aagaaatagc actcagatta aatgttccca gcaaggcaat

421 tttacttcta tagaagggtg catctcacag atggagcaat ggcaagagca cacctgaaca

481 agggaaggga aggggttttt atccctaagg caggtagccc ctacagctgt gttgttcccc

541 tattggctag ggttggacca caccgtctga gctaattgtt actggctatt ttaaagagag

601 caggggtaag agccggattg gcagggtaag tagtttggca ggaaggacgg tcacagaaca

661 ggtgactcag gatgactcag gtcagagcag gtgaccagtg gtgactcagt tcggagcagg

721 tgatagaagc taggaggggg ttgtttactg aaactagggg caaggagacg aagagaacat

781 gaaagttaaa ctttaagatg aagaacaaag ctgaacatac tgatgcattg gatctttgga

841 gaggatctca gaactcattg tacttaattt acaggctaaa accttagaag aggaatttat

901 tatatcctac acaagactcc agggaagcac atggccttgg actgaaggct ggcatctgga

961 agctgtcagc caccagcacc ttctgcagca ggtacctgct ctctaagagg gaggcctggg

1021 tggtgcacct ccagagctgc ccaggctggg cctcaaggaa gaaaaagatt ttcatttgtc

1081 agaggcggaa gggagaggtg gagggaacag cacagcagcg gcccaggggc agggaagcac

1141 aggaccatta gggagacacg agaaagccca tttgtctaga acagaggatt caagcagtgc

1201 accaaggaaa atgagggcca ggccaatgtg ctggagtggc tttgttcttg gctgagggtt

1261 ttgggtagtg ccaaagcgta aggtaagccc tgctttccag aagaatctag cagagtgtgg

1321 agcccagatg ggactggaag gcctgggagg ggtcaggtgg ccacagggac gggccacagc

1381 cagtggtgca ggcaagaaga caatggccat ccatggtggc tcacacctgg aatcccagcc

1441 cattgggagg tcgaggcagg tggatcacct gaggtcagga gttcgagacc agcctggtca

1501 acatggtgaa accctgtctc taataaaatt ataaaaatta gccgggcgtg gtggtgggta

1561 cctgtaatct cagctactca ggaggctggg tcaggagaat cgcttgaacc caggaggcgg

1621 aggttacagt gagctgagat agcaccattg cattccagcc tggacaacaa aagcgagact

1681 ctgtctcaaa aaaaaaaaaa aattagccag gcgtggtggt gggtgcctgt cgtcctcggg

1741 aggctgaggc atgagaatca ctccgggagg cagaggttgc aatgaaccaa gatcacacca

1801 ctgcactcca gcctgggtga cagagcaaga ctctgtctaa aaaaaaaaaa aagacagaag

1861 gatgtcagca tctgatgctg cctgtcacct tgaccctgag gatgccagtc acagctccat

1921 taactgggac ctaggaaaat gagtcatcct tggtcatgca catttcaaat ggtggcttaa

1981 tatggaagcc acacttggga tctgttgtct cctccagcat ggtagaagat gcctgaaaag

2041 taggggctgg atcccatccc etgcctcact gggaaggcga ggtggtgggg tggggtgggg

2101 cctcaggctt ggggtcatgg gacaaagccc aggctgaatg ccgcccttcc atctccctcc

2161 tcctgagaca ggggcagcag ggcacactag tgtccaggag cagcttatga ggccccttca

2221 ccctccgatc ctccaaaact ggcagacccc accttcttcg gtgtgacccc agagctctga

2281 gcacagcccg ttccttccgc ctgccggccc cccacccagg cccaccccaa ccttatcctc

2341 cactgctttt cagaggagtc tggccaacac aaatcctctt gtttgtttgt ctgtctgtct

2401 gctgctccta gtctctgcct ctcccagtct ctcagcttcc gtttctttct taaactttct

2461 ctcagtctct gaggtctcga aatcacgagg cttcgacccc tgtggaccag atgcccagct

2521 agtggccttt ctccagcccc tcagatggca cagaactaca aaccccagca tgcactctgg

2581 cctgaagtgc ctggagagtg ctggtgtacc ccacctgcat tctgggaact gtagtttccc

2641 tagtccccca tgctcccacc agggcatcaa gctcttccct ggccggctga ccctgcctca

2701 gccctagtct ctctgctgac ctgcggcccc gggaagcgtg cgtcactgaa tgacagggtg

2761 ggggtggagg cactggaagg cagcttcctg ctcttttgtg tcccccactt gagtcatggg

2821 ggtgtggggg ttccaggaaa ttggggctgg gaggggaagg gataccctaa tgtcagactc

2881 aaggacaaaa agtcactaca tccttgctgg gcctctatcc ccaagaaccc aaaaggactc EPI-109 11₇₆

2941 aagggtgggg atccaggagt tcttgtatgt atggggggag gtgaaggaga gaacctgcat

3001 gaccctagag gtccctgtgg tcactgagag tgtgggctgc catcccctgc tacagaaacg

3061 gtgctcacct tctgcccaac cctccaggga aaggcacaca ggggtgaggc cgaaccttcc

3121 gtctggtgcc acatcacaga aggaccttta tgaccccctg gtggctctac cctgccactc

3181 cccaatgccc cagcccccat gctgcagccc cagggctctg ctggacacct gggctcccac

3241 ttatcagcct cagtcctcac agcggaaccc aggcgtccgg ccccccaccc ttcaggccag

3301 cgggcgtgga gctgaggctt tagagcctcc cagccgggct tgttcctgtc ccattgtgta

3361 tgggataggg gcggggcgag ggccagcact ggagagcccc ctcccactgc cccctcctct

3421 cggtcccctc cctcttccta aggaaaaggc cagggctctg ctggagcagg cagcagagtg

3481 gacgcacagt aacatgggca acttgaagag cgtggcccag gagcctgggc caccctgcgg 3541 cctggggctg gggctgggcc ttgggctgtg cggcaagcag ggccc

(2) INFORMATION FOR SEQ ID NO: 32: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23142 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 32: ggatcccatg ccctgcctca ctgggaaggc gaggtggtgg ggtggggtgg ggcctcaggc

61 ttggggtcat gggacaaagc ccaggctgaa tgccgccctt ccatctccct cctcctgaga

121 caggggcagc agggcacact agtgtgcagg agcagcttat gaggcccctt caccctccat

181 cctccaaaac tggcagaccc caccttcttg gtgtgacccc agagctctga gcacagcccg

241 ttccttccgc ctgccggccc cccacccagg cccaccccaa ccttatcctc cactgctttt

301 cagaggagtc tggccaacac aaatcctctt gtttgtttgt ctgtctgtct gctgctccta

361 gtctctgcct ctcccagtct ctgagcttcc gtttctttct taaactttct ctcagtctct

421 gaggtctcga aatcacgagg cttcgacccc tgtggaccag atgcccagct agtggccttt

481 ctccagcccc tcagatgaca cagaactaca aaccccagca tgcactctgg cctgaagtgc

541 ctggagagtg ctggtgtacc ccacctgcat tctgggaact gtagtttccc tagtccccca

601 tgctcccacc agggcatcaa gctcttccct ggctggctga ccctgcctca gccctagtct

661 ctctgctgac tgcggccccg ggaagcgtgc gtcactgaat gacagggtgg gggtggaggc

721 actggaaggc agcttcctgc tcttttgtgt cccccacttg agtcatgggg gtgtgggggt

781 tccaggaaat tggggctggg aggggaaggg ataccctaat gtcagactca aggacaaaaa

841 gtcactacat ccttgctggg cctctatccc caagaaccca aaaggactca agggtgggga

901 tccaggagtt cttgtatgta tggggggagg tgaaggagag aacctgcatg accctagagg

961 tccctgtggt cactgagagt gtgggctgcc atcccctgct acagaaacgg tgctcacctt

1021 ctgcccaacc ctccagggaa aggcacacag gggtgagccg aaggcccttc cgtctggtgc

1081 cacatcacag aaggaccttt atgaccccct ggtggctcta ccctgccact ccccaatgcc

1141 ccagccccca tgctgcagcc ccagggctct gctggacacc tgggctccca cttatcagcc

1201 tcagtcctca eagcggaacc caggcgtecg gccccccacc ettcaggcea gcgggcgtgg

1261 agctgaggct ttagagcctc ccagccgggc ttgttcctgt cccattgtgt atgggatagg

1321 ggcggggcga gggccagcac tggagagccc cctcccactg ccccctcctc tcggtcccct

1381 ccctcttcct aaggaaaagg ccagggctct gctggagcag gcagcagagt ggacgcacag

1441 taacatgggc aacttgaaga gcgtggccca ggagcctggg ccaccctgcg gcctggggct

1501 ggggctgggc cttgggctgt gcggcaagca gggcccagcc accccggccc ctgagcccag

1561 ccgggcccca gcatccctac tcccaccagc gccagaacac aggtaagggc caggcagcta

1621 ggagcaggtg ggcaacaagg gtggtgteaa ggcctgaagc etggggctgg gaaggtctgg

1681 aacttgtagc tgagtcggga gggccaggtc acaaatgcaa aagggctatt aatgtgcata

1741 gaacaggaca gtctgggagg ctcagaaagg agaccaggat cagagtcggc aggtgaagct

1801 gggagtaagg gtgccagcta tagaatctgg ccagggtttg aatgctgctc tgccgccagg

1861 agctgtttga ctttgagcaa gttacttaat ctctctgaac ctccatttat ataaaacgag

1921 atatggcaat acttactcca tggggaagta agtttctagc tcacagcaag ccttcaacag

1981 cagcgatgat tatttagctg gagaagaaag gagctgacag cagtggttac aggagtgaga

2041 aagtggggtc tcccagaaga gggagagagt tgggcaggaa actcgggccc ttggggtaag

2101 caggctgaga agacagagcc aceaggcttt tttcccctgc tceagccecc tctcctcgtg

2161 gctgtcaccc gaaaactgga ccatgcagtt cccacaagag tcctcccggg ggtagaggtc

2221 ccaggaggga ggaaagaccc ggaggcctgg tggggtgcca ggccgggggc aggctggggc

2281 tgcaggcagc tatgcaggga aggctgaggg ccggggccct gctgctcagg cgcacccttg

2341 gcctgagtcc ctcccttcct ccctgccgct ggtggctctg ggaggaagtg ataaggcctg

2401 cgaggcttcc cttcacacat ggggctgctg tcaggagggg ttgtgagtgc ggagggaaat

2461 cagagctgag gaatccctgc agggcttccc tccactcaag caccaggctc tgtccccctc

2521 agggtagggc ttatagcagc tttgcggggg gtggacaccc catctccaga agaggtgagg

2581 tgggcgctgc aggtgggatg cgaacttagc ctcgggtcag gggctcagga gctcagcacc

2641 agcagcccct gcagcccagg accctggtct ataaacggag gcacagctcg cctctagctc

2701 ctaaggcatg gggaacgcca gaaggcatgc ggcaggtggg ctgtgagatc gccagtgctg

2761 taacaggggc ctccgggtga catctgggaa ggctgaaagg aaacaaaccc ttcctgatga

2821 ccctatccct ggctcccaac agccccccga gctccccgct aacccagccc ccagaggggc

2881 ccaagttccc tcgtgtgaag aactgggagg tggggagcat cacctatgac accctcagcg

2941 cccaggcgca gcaggtaagg ccggcatgcc ctgtccccat cgtctccagg gaaagggtgg EPI-109 1177

3001 gtaaggcctg gcctcagatg gggccggaga gggaagctca acccttcttt gaattggtcc

3C61 cttgtttcca aaaagaggag aggactggga agaaccagag gagttgaggg acatgcacgg

3121 gacttgggtg accctcagcc tccagcctta cccccaaccc tggctcaaac ttttccccca

3181 tcccacccct gcaccccttt tccccctccc acccctgcac ccttcctccc tctcccccac

3241 cccacccctg ccccccctcc catcccagct ctaaacccct cctccctctc ccccgtccca

3301 cccctaaacc ccacctccct gtccccctct aaacccctcc tccctgtccc cctctaaacc

3361 ccacctccct ctccccatcc cacccctgca cccttcctcc ctctgccccc gtcccacgcc

3421 tgtactcctc ctccctctcc cccgtcacac ccctgcaccc ctcctccctc tccccatccc

3481 atccctgcac ccctcctccc tctgcccccg tcccacccct aaacccctcc tccctctgcc

3541 ccaccccacc cttgcacccc tcctccctct tcccccgtcc cctgcctgca ttcctcctcc

3601 ctctccccat ctcacccctg cacccctctt ccctctccca cccctgcacc cctcctccct

3661 ctccccgtcc caccctgcac tcccgccctc tccagcgtcc cacccctaca cccctcctcc

3721 ctctgcccca ttccacccct gcaccccctc ctccctctgc cccgacccac ccctgcaccc

3781 ctcctccctc tcccccgtcc cacccctgca tccctcctcc ctctgccccg tcccacccct

3841 acacccctcc tccctctccc ccatcccacc cctaaacccc tcctccctct cccctgtccc

3goι atccctgcac ccttcctccc tctccccgtc ccatccctgc acccttcctc cctctccccg

3961 tcccatccct gcacccctcc tccctctgct cccatcccac ccctgcaccc ctcctccctc

4021 tgcccctacc ccacctctgc acccctcctc cttctcccca tcccacccct gcacccctcc

4081 tccctctgcc cctaccccac ccctgcaccc ctcctccttc tccccatccc acctctgcac

4141 ccctcctccc tctcccctct cccacccctg tacccttcct ccttctcccc gtcccacccc

4201 tgcacttctc ctccctctaa cccatcccac ccctgcaccc ttcttccctc tcccccatcc

4261 caccactgca cccctcctcc ctctccccct gttccacccc tgcacccctc ctccctgccc

4321 ccaactccca tcccacccct gcaccctggc ctgtcctgac ctttgcactc cctcgaccca

4381 ggatgggccc tgcaccccaa gacgctgcct gggctccctg gtatttccac ggaaactaca

4441 gggccggccc tcccccggcc ccccggcccc tgagcagctg ctgagtcagg cccgggactt

4501 catcaaccag tactacagct ccattaagag gtgacagctt cccggacgcc acagcctccc

4561 ttgtcccact gaggccccag aaaccccgtg acgaccttcc catgaccccc tcccttccca

4621 gatcctaaca ccacgtgggc ccctcccgcc ctcccccagc acttgcacaa agcctggagg

4681 agggcctccc tgtcccacac aacttcctgc ttgtcccctt cccacccctc tcctccccag

4741 gagcggctcc caggcccacg aacagcggct tcaagaggtg gaagccgagg tggcagccac

4801 aggcacctac cagcttaggg agagcgagct ggtgttcggg gctaagcagg cctggcgcaa

4861 cgctccccgc tgcgtgggcc ggatccagtg ggggaagctg caggtgcggc tggccagcga

4921 ctgagagacc cgggcgctac caaaagggga gcggggtggc ggggcagttc ctaaggcttc

4981 ccgggggctg ggaggtceca aactgtgggg gagatccttg ccttttccct tagagactgg

5041 aaaggtaggg ggactgcccc accctcagca cccaggggaa cctcagccca gtagtgaaga

5101 cctggttatc aggccctatg gtagtgcctt ggctggagga ggggaaagaa gtctagacct

5161 gctgcagggg tgaggaagtc tagacctgct gcaggggtga ggaagtctag acctgctgca

5221 ggggtgagga agtctagacc tgctgcgggg gtgaggaagt ctagacctgc tgcgggggtg

5281 aggacagctg agcggagttc cctgggcggt gctgtcagta gcaggagcag cctcctggaa

5341 aagccctggc tgctgcttct cccccaagag agaaggcttc tcccgccagg ccagtccagt

5401 gcagcccctc acccacaccc actgctaccc cagttcccct gcttcggccc gcaccctccc

5461 tcacacccca gcceacagac tcggggctgg ccttagttac tggaacgcct gtgaccacag

5521 cactaagaga agcaagctgc cccatggggg acttggtccc catggccttg gcctccttca

5581 ccatcactgg cegccaaaga gtttgaaata aagccacgtg cccagtgaat cccaaaggaa

5641 cctcaactaa aataaaaaca atcctatctg acacttgcct gaccctctaa gtcattcaaa

5701 gctttagctc aacttcgatc catctgagct gccatagtgg accccactca gagctgcgtc

5761 ecteccttga ecccaggttg gtccctgcca ctcccctgcc cetgtcactg acacatgttt

5821 cctcctccct caggcaggag tgggacctcc cagcctcctc ctggggcctc cactcagaat

5881 gtcaggatga gcagggtcct aggaggcctc tggtgcagcc ttcccttccc accatccatg

5941 tgctcaaaga gaatcacccg tcctttcttg aatgccatgg atcatggggg atttgctgcc

6001 cacactccta ggcggcctct tagacatccg ttggtgccta acccaagcat cagtttggca

6061 gaggccgagt ccctcctctg tactggatac caagtcagct tccataggga tggggagaca

6121 cctggcccag ggaggagatg agaagcagcc cggatggtgc tacatatgtc agagagcagg

6181 gcaggaaggg atcagtgtgg ctgccaatgg tcaggagggc gccatggagt gaaccatggc

6241 ccctgcctcc tcaaccaaga agtcctctgg agctgatact caagaccccc cgtctctctc

6301 ctcaccctcc tctcccgctg cctcggctgg ctcaggtgtt cgatgcccgg gactgcaggt

6361 ctgcacagga aatgttcacc tacatctgca accacatcaa gtatgccacc aaccggggca

6421 accttcggtg agtgcccccc accatgccag gccccagcct tcttccccaa ggcagggaag

6481 gcggggctct gaccagctct ttccccatgc gtgccagctc ggccatcaca gtgttcccgc

6541 agcgctgccc tggccgagga gacttccgaa tctggaacag ccagctggtg cgctacgcgg

6601 gctaccggca gcaggacggc tctgtgcggg gggacccagc caacgtggag atcaccgagg

6661 tgggcaccga gggccaccca tgagggtgtc cccaaggtgg agaatgagga aaccagtggg

6721 agaaggctcg ggggatccag gcaggaagag gggagcctcg gtgagataaa ggatgaaaaa

6781 caccaaagga ggggtgcctg ggtggtcacg gagacccagc caatgaggga ccctggagat

6841 gaaggcagga gacagtggat ggaggggtcc ctgaggaggg catgaggctc agccccagaa

6901 ccccctctgg cccactcccc acagctctgc attcagcacg gctggacccc aggaaacggt

6961 cgcttcgacg tgctgcccct gctgctgcag gccccagatg agcccccaga actcttcctt

7021 ctgccccccg agctggtcct tgaggtgccc ctggagcacc ccacgtgagc accaaaggga EPI-109 1178

7081 ttgactgggt gggatggagg gggccatccc tgagcctctc aagaagggcc tgcaaggggg

7141 tgctgatccc acaccccaac acccccaggc tggagtggtt tgcagccctg ggcctgcgct

7201 ggtacgccct cccggcagtg tccaacatgc tgctggaaat tgggggcctg gagttccccg

7261 cagccccctt cagtggctgg tacatgagca ctgagatcgg cacgaggaac ctgtgtgacc

7321 ctcaccgcta caacatcctg gaggtgaggt gcgggatggg gctcgggcac cgaatgcacc

7381 tgtccaaggc aggagtctgg ctctcactcc atccccaaaa tgccagccac ggggacaatc

7441 agagcaggtc cagggttgcc tcctaaatgg gaactgagga caagctctag aaccactgaa

7501 gcaaaggggt agggggtggc aggggtgtgt gtgggggtgt gagtgggtga gtgtgagagt

7561 gtgggtttct ggggtgtgca gtgggtgaga gtgtgggctt gtggggtgtg tagtgggtgt

7621 gagactgtgg gtttgtaggg gtgggtgagt gtgggtgtgt gggggtaggt gggtgtgggt

7681 ttgtgggtgt gtataggcag tgactgtgag actgtgggtt tgtgggggta ggtgactgtg

7741 ggtttgtggg gtgtgtaggg gtgagtgtgt gtgggtttgt aggggtaggc gagtgtgggt

7801 ttgtggggtg tgtaggggtg agtgtgtgtg agtttgtagg ggtaggcgag tgtgggtttg

7861 tggggtgtgt aggggtgagt gtgtgtgagt ttgtaggggt aggtgagtgt gggtttgtgg

7921 ggtgtgtagg gggtgtgtgt gggcttgtag gggtaggcga gtgtgggttt gtggggtgtg 7981 taggggcgag tgtgagagtg taggtatgtg ggtgtgagtg tggatgtgtg taggcggtga 8041 gtgtgaaatt gtgggtttgt gggggtgggt gggtgtgagt gtgtgggttt gtgggtgggt 8101 gtgggtgtga gtgggtgggt gaggggggca tggggatggg tgtgaacatg tagttgttct 8161 ttcaggcata ggacccatag ctctagagct ttcatcagat tctcaaaggg gaccttgact 8221 cggaaaaggt taagacccat tttagagatg agaaattaaa gcctggagct gaggagcgac 8281 tggcccaaag tccctctctg ctctgaggtg cttcgcaggc aaaaacctga accagccccc 8341 taggcagcca ggcctcccaa tggacaccac tcacctcact ccttccagcc atgtacggga 8401 aacagagata gtctccccac cccacccccg tgatcacctc tgtccctacc gatgccacac 8461 acccttctgc cccaggatgt ggctgtctgc atggacctgg atacccggac cacctcgtcc 8521 ctgtggaaag acaaggcagc agtggaaatc aacgtggccg tgctgcacag ttaccaggtg 8581 cagaggccca gactggccag gaaggcaaag ggtttgcata cgggggcagc aggggcgggg 8641 gatggaggag aggcagccat ttagaaacta gggcaggatt tggacaggca gaagaagttc 8701 cgtagtccca gtgccatggc gcacactggc tgcggttcgg ggacagggca ggtactattc 8761 caggcgctgt catctggtgg cttactgtgt gccagggacc ttgctgttta ctgcatgccc 8821 agtcatgctg attctcaggg catattgggt attgcagttt gtgggacccg ctggatcctg 8881 gaaacaaata ccaggatcaa gggcacacca ggagtcgtag tttgaggaag ccggggcctg

8941 ctgagaattt ctgtgggcta tttggtttgg ggaccaggca tgcagatgct ggagattaga 9001 gctgcttgtt gcatgttgaa cctgcagcat gaccatgcat gatgtggttt ggggtgaggg 9061 tgacattgtg gtttgagggg acacagggtg tgttagatat ggggtaatcg agggcacatg 9121 tggtttgggg tgaccggagt ggtggaggaa gaatgggcga ggtctgtggg tctggtttga 9181 gcctctcccc ctctctctcc cttccagcta gccaaagtca ccatcgtgga ccaccacgcc 9241 gccacggcct ctttcatgaa gcacctggag aatgagcaga aggccagggg gggctgccct 9301 gcagactggg cctggatcgt gccccccatc tcgggcagcc tcactcctgt tttccatcag 9361 gagatggtca actatttcct gtccccggcc ttccgctacc aggtgcccac cctaatggct 9421 ctgccagcct gggcccagct ctaattctaa gcagcccctg gggacctcta acctttcctt 9481 ttctttacct cccctcccaa ccccatcatc tctctgcagc cagacccctg gaaggggagt 9541 gccgccaagg gcaccggcat caccaggaag aagaccttta aagaagtggc caagtgggtc 9601 ccctgggagc cccgctctcc cacacacacc ctgggggccc cactctcccc cacacaccct 9661 gggggaccct gccccagcag tgttctggac ctaccactca gtatcccaaa accctgttgt 9721 gagggggttg gacccttgcc tggggaggcc ctgcctctgt gcacccggga caccctcaca 9781 ccttcctctc ccgcagcgcc gtgaagatct ccgcctcgct catgggcacg gtgatggcga 9841 agcgagtgaa ggcgacaatc ctgtatggct ccgagaccgg ccgggcccag agctacgcac 9901 agcagctggg gagactcttc cggaaggctt ttgatccccg ggtagggctg agcccagggg 9961 agcagggagc tagaaagagg gggctctatc agcatcttca ggggtgccct ggaggacagg

10021 aagtgttaca agtcaggact catgaggaac ccggaaccac aggtgttcag agatcaagtt

10081 ggggcctgaa tcttgcactg ccagggaggc cagagtgagg agggcagggc ctccgggggc

10141 cacagcaccc aggacatctg tcttcccacc cacaggtcct gtgtatggat gagtatgacg

10201 tggtgtccct cgaacacgag acgctggtgc tggtggtaac cagcacattt gggaatgggg

10261 atcccccgga gaatggagag gtgagaactt ccaggaaagg ggctgctggg aatgaggaga

10321 gactcagaat tggagtgact gggcaggaac ctctgcccaa cacacacaca cacacacaca

10381 cacacacaca cacacacaca cacacacaca cacacacaca cacacacaca cgccaggatg

10441 gaaagggaga tgctaagaga cccctggagc ctgaaacccc acacaacgta cgctcccagc

10501 ccacccatgt ggctgcctcc ctgcaagcac atttgcttaa ctgcgcgtcc ccaagtcatt

10561 tccattatca gtgcaagttt ttaatacaag gaaggcacat cctggctgac caagaggtta

10621 gactgtgctc gggcactgac aagaaaaaca gggatacgtc actgagggcg gcttctagga

10681 tgcgggtaat gtttcttaat gggatactgg ttacacaggt gtgttcagtt tgtaaaaatc

10741 cacagagctg tacatttaca acatgtacaa cactattcca gcattttatt ttatttgttt

10801 tatttatttt gataacctat ttacgttgcc caggctggcc ttgaactcct agcctcaaga

10861 gatcctcctg ccgcaggctc ctttttcaaa agaagaaatt gagcgctgtt tagatgccaa

10921 catagattaa ataacttcac tttttaaaaa gaaacacaaa gctagagtac catcattgaa

10981 ttccttctct tgcaagctta ggtatctctg aggtgcccca ggctaggctc atttctgagt

11041 cttacctgct ccagcttcta ggtgttaaag gccttattag cactaagtac ttcctcagta

11101 ctcttttttc ttttttcctt tgagacaggg tctcactttg tggcccaggc tggagtgcag EPI-109 1 179

11161 taσtacaatc acggctcact gcagcctcaa cctcctagac tcaaσcaatc ctcccacttc

11221 aacctcccaa gtagttggga ctacaggcgc atgccatgat gcctagctaa tttttgtatt

11281 ttttatagag atggggtttc gccatgttgc ccaggctggt ctctaactcc tgggttcaag

11341 caatccacct gcctcggcct cccaaagtgc tgcgattata gacgtgagcc actgcacctg

11401 gcccgcagta tcttaagcaa gttggaatct cgtgaaaccc tttttgctgc cttagtgtcc

11461 gtttcagccc tcattcttac ctaccttttc aagaaaaata gcaccagcaa ttgacttttt

11521 tttagcataa aggtgtatag aacccatata acctacagcc ttcacaaggc atagcacatt

11581 ttcaccaccc tggaaagttc cctcatcagt tcctcacgtg aatcccttcc cagtctgtct

11641 ccctgccaga agtgtctgtc accacagaat agtttcgcct gctctagaac ggcacctaga

11701 tggaagcacg cagtgttgcg gcgtctcctg ctgaggctgt ttttgaggcg cactcgtgtt

11761 gctgcgtgac tcagtatttc actcattctg ctgctgagtg ccgttcattg tgtgaatatc

11821 cccagtttgt ttacccattc tcttgttggt gacacttggg ctgtttccag gtcggggcta

11881 ttatgaataa acctgttatg aacattctgt acccggcttt tgtgggctta tgtttttatt

11941 tctcttgggt aaaacctagg agtagaattg gtaggtcata gggtagatgc atgtttaatc

12001 tttcactttt ttaaaaaata aaactgccag gccaggcgcg gctgctcacg cctgtgatcc

12061 cagcactttg ggaggcccag gtgggtggat cacttgaggt cagaagctca agaccagcct

12121 ggccaacatg gcaaaaccct gtctctacta aaaatacaaa aattagctgg gcatggtggc

12181 gcacgcctat agtcctagct actcaggagg ctaggcggga gaattgcttg aacctgggag

12241 gtggaggttg cagtgagccg agatcacgcc actgcactcc agcctgggtg acagagcaag

12301 aattctactt aaaataaaat acaaataaat aaaataaaac tgtcaaacag caaagcaaat

12361 taaactgccc tttaacatct gtgcagttca atgtatgtta attttatccc aaatttttaa

12421 caaatctagg aatacagctc acagaaaatg gggtatattc actaaaaata aggaatattt

12481 atagcaaatt tgtttgtaat accccacact ggaaacaatt caaatgacca tcgacaaata

12541 ctgataaatt gtggtatatt caagtgccat atcgcactaa gtgtgaacga aacacaacca

12601 cacacaacag tgcaggtgaa tctgaaaaaa tgtgaagaga agaaaaagcc agaccaaaga

12661 atacatactg tactacaggg ttcactttat ataaagttca gaaacaggca gaactaatcc

12721 acggagttag aaattaggag aggagttagt cactgggatg ggggtggcag tgacaggaag

12781 aaggcacgaa gttggcttct aggatgcggg taatgtttgt ttgtttgttt gtttgtttgt

12841 ttttgttttt gagctggagt ctcactctgt tgcccaggct ggagtgcaat ggcgtgatct

12901 cggctcactg caacctccgc ctccccggtt caagcgattc tcctgcctca gcctcccgag

12961 tagctgggat tacaggtgcc cgccaccatg gccagctaat ttttgtgttt ttagtagaga

13021 cgcgtttcac catgttggcc aggctggtct tgaatccctg acctcagcct cccaaagtgc

13081 tgggattaca ggcgtgagcc accacgccca gccacgggta atgtttctcg atgggatgct

13141 ggttgcacag gtgtgttcag tttgtgaaaa cttacagagt tgtacattta caacatgtgt

13201 gcacctctgg acttgtgttg cacgttgaca aaacattcaa aaatgaaatt caaatcgttc

13261 ttgctaactc tggcgcactt gggaaccagc acccagaggc atctgcagtt gagcaccaga

13321 tgcagttcct tccagcttcc ttccccctgg gaggtccgct tgatgccact tcttcatggc

13381 agcacaaaca aggccatggt cttctgagga gggcaacctg cacaatgtct gctagtgacc

13441 aggacactgc tgaaggaact gagagtttgt ccacccatga aatccactaa aacaggaaag

13501 attttgctct agccgttgtt agccaggagt gaggaaagag ctgtgccctc ccctgcagct

13561 gcgaggacga tctgcctgcc ccaacaagtg gggattcagc aactccactt ctaaggatta

13621 cccagctgaa gcatttaaaa gtgggagcaa ggcacacgta caagggcgtt tgagagagca

13681 cctgttccca gaccaccgag ctgcccttca gtctcagtga agtacaatgt agccactaaa

13741 aagactgagg tcatgttttg gaaagtccag gccggaggat cgcttgagcc caggagttca

13801 aggccagact gaacaacaca gcgagactcc atctcttcag aaaatttaaa aattaaccaa

13861 gagtggtggc acgcacctat agatctagct actaggaagg cagaaaaatc ccttaagccc

13921 aggagtttga ggttacagtg aatgatgatg gagccactgc accccaacct gggcgacaga

13981 gcaagaccca tatctaaaaa caatactact acttacgtca atattgttgt attgacctgg

14041 agggatgtct gcaataaatt attgattaaa accaaggaag tacagtatgg taccactttt

14101 acttaaaaaa aaactataaa tatgcacgtg cacgtaagtt caaggaaaaa gggctggaag

14161 gttaacacct gtgaatggcg catatgcccg gaggaagatg gggtggtctt tgtcttatca

14221 ctttacacat ttctgtaatg tcatttttca aaaacatcag atcgcttttg aaattttcaa

14281 aacaaataaa aattaagtga caaatcaata ataatgagga tcagctggta cagttttaaa

14341 cttctatgta gtttgaaatg aaacaaaact aaccctgatg caaacactcc cctcgccaga

14401 gctttgcagc tgccctgatg gagatgtccg gcccctacaa cagctcccct cggccggaac

14461 agcacaagtg agttgggtga gagtttgggg gagctggggg agctgatgca tttggagaca

14521 caaacagaaa gggggtctga aaagctctcc ctctgtgcct caagtcgttt tcccaccaaa

14581 agccagggct ccaggatgcc ctccattcca ggctgcaatg gcagtccaga cctgcctgct

14641 tctgagagcc gggacagtcc tgaggtcttc agagatgggg gtgtggtgtg tcagggcccc

14701 aggctcggaa ccccagggat gctggccctc agcccctccc aagggcaggg cctttcctgt

14761 ccagaggcag agaccctgaa gccgtccctg gggctgggtc tgggcctagc ctgtatcccc

14821 agggccctgt gacaaccttg tctttgtcct ctcttgccag gagttataag atccgcttca

14881 acagcatctc ctgctcagac ccactggtgt cctcttggcg gcggaagagg aaggagtcca

14941 gtaacacaga cagtgcaggg gccctgggca ccctcaggtc agggcctcac caagaggggt

15001 gcaacgggtg ggcaagctgc ctgggcaaac gtggcctgca aagggagctc cactgacgac

15061 ccctgcaccc caggttctgt gtgttcgggc tcggctcccg ggcatacccc cacttctgcg

15121 cctttgctcg tgcggtggac acacggctgg aggaactggg cggggagcgg ctgctgcagc

15181 tgggccaggg cgacgagctg tgcggccagg aggaggcctt ccgaggctgg gcccaggctg EPI-109 1180

15241 ccttccaggt gagcccagcc cagcccctgc tctgactcct gccccctggg atgcctcctc

15301 etgcctcact ctgccctgat tctgtttggt tctttggtcc cttcctgttc cttccaaaat

15361 ccaccctcat ctctccatgg catagccagc tcttctgggt caggggcaga ggatgacatg

15421 gccctgccga ccacaggggt gcctagccca ggcagaagtg cagccgaaag agagcaggca

15481 gggccctggc aggagggagc ttcagccagg cacaggctgg gcctcacaag tgggcgcaca

15541 aagggagggg gtgcagggca gggcagggga ccccacccag gatgggcagg atggagggag

15601 aaggaaggga cagagagaag gtcagacaga ggcaagggct gaagctgagg ccagcacaga

15661 agccacagga agccagaggc cagacagcct ggggcggtgc ctgcaccaga actggtccgg

15721 gccaggcaag caagcacagg gagaggtgga tccctggggg ctgtggcttt ttaagcctgg

15781 gcttcctcag gggcagtgct gcctgtctgg ggatcatgtc tgcagttgac aagggctcgg

15841 tctccccagt gccacactgt tcagggcagt gctgctgtcc cggggcccag gctggagctc

15901 agcagatttg ccttgattgg aggaggaggg catcctagga ggagagggag tgggggctac

15961 ctcagggacg gggaggtcag gctgcagaaa cacataggcc ctgattggga agaagggaca

16021 cggtaaaata agctctaaaa gaatttaaaa caaaaagagc cattgcagcg ggatgagacc

16081 acatcatcag gttttgggaa taggacttta gaggcgtagg atccattaca gcatcaccga

16141 accagaagca ggaaggctga gctaagcaga gcagcagcag tggagatagg aaggaaggga

16201 gggaggggcc gaggaaggaa ggaagagata taagacttca cacgcaccac aaaagaaaga

16261 ttaacgggac ttggtgatat gaggctcagc caatcacggg tgagccctgc atttcaagcc

16321 tgggactggc ccagcagttt tccagctgtg tgcctgacca ggagtagacg ggatccacac

16381 cctcccaggg atctgccccg tggggtcccc tctgccgccc gaattgtgcg tcccttccca

16441 ggagcactta ctatctgcac gcactttgtg gaaagctaag ggctttacat aaagtatctc

16501 atttaatctt caccagaaca caatgaggtg taaagatggg gaaactgagg catgtcactg

16561 taagtacggg attcggaatt tgaatgcagg tctgaacaca cagacgcctt cacagagcta

16621 ccgtgtgcca agcactatgc ttctcggatc acgggattaa cacgcaccag ataaggaacg

16681 atgcaccaat caggacgtgc agagaaagag ccagccgggt ccctgggccc agcggccaat

16741 ccatgaaatg ggctggcgga aaaggtgctg tccttggcgc cggcctcagc cactggggct

16801 gccaaccccc caggagcaag acgcagtgaa gccgcccagg cgcctcacta gggcgacccc

16861 tggtggcggg aggtcctcag ccctcaccgg cctgtcccgc aggccgcctg tgagaccttc

16921 tgtgtgggag aggatgccaa ggccgccgcc cgagacatct tcagccccaa acggagctgg

16981 aagcgccaga ggtaccggct gagcgcccag gccgagggcc tgcagttgct gccaggtggg

17041 ccctgcctca ccctaacccg gctggttctc tgaggccccc acaccccggg actaaagcac

17101 tctggggcca ggccctgctc cctagctcag gctgcctcat ttgcccctcc ccgcccccag

17161 gtctgatcca cgtgcacagg cggaagatgt tccaggctac aatccgctca gtggaaaacc

17221 tgcaaagcag caagtccacg tgaggacgac ggctttaccg ccccccaacc cctgtcctga

17281 acaccctgac cctggaccct cctcctccca cattctcccg cccccacccc tctctgactc

17341 cccataagtg cccctctccc cacccccagg agggccacca tcctggtgcg cctggacacc

17401 ggaggccagg aggggctgca gtaccagccg ggggaccaca taggtgtctg cccgcccaac

17461 cggcccggcc ttgtggaggc gctgctgagc cgcgtggagg acccgccggc gcccactgag

17521 cccgtggcag tagagcagct ggagaagggc agccctggtg aggggcagcc tgggaagcaa

17581 cagggcacac cagccccatg cccagcccca cccccggccc caggcctcca ggagctcagg

17641 acccgaccca gggggtggcc acctcctcca cagctcagca ggcaggctca gagctggctg

17701 tgctgcccac tgccgggctg gccttgttgc tggaccatcc ccacaccctc aaatgcaccc

17761 ccaccaaaag gctgtcccct ccctctgggc tcctctccaa ggctccccta gcaatctagc

17821 ttgctctgga gctggcactg gggctatttg ctgccacatc aatgcctggg ctttatttaa

17881 aataaggggg tggagtcaga ggcagaggag cccagaccaa cccagtccgg ccaggggccc

17941 ccgaacaata cactgaggct acctagacag gccgaccccg ctgctcaagg gcaggctctc

18001 taacagtcac caaaacacaa acatcagccc aggtactgca gtcctgctgg gccctgtcct

18061 cagagctccc tgtgcactat ccccaggtgg ccctcccccc ggctgggtgc gggacccccg

18121 gctgcccccg tgcacgctgc gccaggctct caccttcttc ctggacatca cctccccacc

18181 cagccctcag ctcttgcggc tgctcagcac cttggcagaa gagcccaggg aacagcagga

18241 gctggaggcc ctcagccagg ttgggggcca ccccaatgag gcacaggggc tagagagacg

18301 ggatgagctg gggggacccc agtggcagga aacccccatg caaagtcccc cctggacttt

18361 cttctcctgg ctgacatgca ctggtgcttt aagacccagc tcctcaggga ggaattcatg

18421 gctggattct ccaggtctta gagaaaactc tattggcctg aactgagcag ggagaaaccc

18481 taaagaggct cagtggggga ggggtcaaga agggaggtta ctaggaaggg ctatggggcc

18541 tccaacccac tgcatcctgc cccgccagga tccccgacgc tacgaggagt ggaagtggtt

18601 ccgctgcccc acgctgctgg aggtgctgga gcagttcccg tcggtggcgc tgcctgcccc

18661 actgctcctc acccagctgc ctctgctcca gccccggtac tactcagtca gctcggcacc

18721 cagcacccac ccaggagaga tccacctcac tgtagctgtg ctggcataca ggactcaggg

18781 tgaggcaaca agcaggagca ggcctggcca cagcagggtt gggaccggcc cctctctggc

18841 ccctcaccgg cctctccttc ccacccccag atgggctggg ccccctgcac tatggagtct

18901 gctccacgtg gctaagccag ctcaagcccg gagaccctgt gccctgcttc atccgggggt

18961 aagtgagatg gaggacttgg tggggagctg cccagggtca gggtggcagc tttggtgagg

19021 agtgtcactg gtgaggggtg tcactggaaa caggaaggag ctctgtaaca tgtcaagggt

19081 gtggtgtcat taggtcactt cagaactctg gctaagcttt ggctctctca ttcatttaga

19141 ctcagagttc tgccctgaaa ctatagctcc cagagccaga gctggtatca aaccggctgg

19201 ccctgtggct ttctgaaagc ttctgtgttc ctctctatgt ccctgggctg tctgatgttg

19261 ggcagcatgg cacctgggaa ctacagtcac taaatcctca ctcaatccag ggagaactac EPI-109 1181

19321 tagttagggt taagaccacc ctttggcctt ggtgtcacca aggactcaaa gaaggtgaag

19381 gttttggttt ttttttcccc cagagatgga gtcttgctct gtcgcccagg ctggagtgca

19441 gtggtacgat ctcggcttac tgcaacctcc gcctcccggg ttcaagagat tctcctatgg

19501 cgtgaacctg ggaggtggag cttgcagtga gccaagattg tcccactgca ctccagcctg

19561 ggcgacagag ccagactctg tctcaaaaaa aaaaaaaaaa tattctcctg tctcagcctc

19621 ctgagtagct gggattacag gcacccacca ccacgcccag ctaatttttg tatttttagt

19681 agagacggtg tttcactatg ttggccaggc tggtctcgag ctcctgacct cacaatcctc

19741 ccacctccgc ctcccaaagt cttgggatta caggtgtgag ccaccgcgcc cggaccgagg

19801 gtgaaggatt ttaagagacc cttccttcat gctgtgtcca gaagtcttgc ccgctctcgc

19861 agccaggaac caaaagtcct ggtaggactg agaacagttc ctaggctgcc atcagctggg

19921 cctggtgatt caaatccacc caggtggcta aactacaaat aaaccgtacc catctactga

19981 acataaacta aataccacta ttaaggatac ttaaaataaa cacacttagt gaacccatta

20041 tgaactgaaa gtgtctttca cccttcccac gttttctaaa tcccctgagt catctaagta

20101 ttcttcaatc caaaatgaac tatatttcct ttggtgcaat ctccagaaac cacagatcca

20161 aggagtttca gcaagtagag ttgttttttg ttttttgttt tttttttaat ttttttttga

20221 gatgggaaga acttgggtcc tccttgctcc acccaccctg catggtgaga atggtggagc

20281 aggaaaggca aaggggacct gatggagtgt ctctcctgcc agggctccct ccttccggct

20341 gccacccgat cccagcttgc cctgcatcct ggtgggtcca ggcactggca ttgccccctt

20401 ccggggattc tggcaggagc ggctgcatga cattgagagc aaaggtgagg ctggtgacta

20461 aaggactgcc tgaagggagt cacacaatct agggacagag gggtggggct ggaaggcagg

20521 aaataggaaa gagagggcag gaaacaaagt ccacaaagct gaaaagacgc tcatgagacc

20581 aaggggaggg caggtaccaa aggcaagggc tgggccctga gcttctggct tcctggtgcc

20641 tggtacatag taggtgttga ctggattgag gacaaaggaa aatagaattt tcaaagggat

20701 tagggctaag actcaaagaa gaactgccca aggtggattc ttgactgtgc cagagctgac

20761 cgaggtctgt ccaagaccta aggatgctac aaggtgttca tattgagcat ggggtgccca

20821 gggtggtctg tcaatcaaaa gaagagggct gtgactggga ggagagttat aagtatggga

20881 gaatatgaag tgggagcggg gaaggggact gcgatgtcac acaatgcaaa gggcatggaa

20941 ttctgagtcc gaagccgcgc attctagcgc actccaccag gggccaccac ctcacccgcg

21001 cttcccttcc ctctgtaaat cagggctgtg cagggtctct gtgaaagcat tctacactct

21061 cttagagatg aaacagccaa agtaatggtg gtttcagccc aaaacgctgg gctgccaggc

21121 tgggcgacgg tggcctgtgg ggaggcccca ctagcactgt gccccggaga agagccttcc

21181 caagcgcggg gttgcttgca gggctgcagc ccactcccat gactttggtg ttcggctgcc

21241 gatgctccca acttgaccat ctctaccgcg acgaggtgca gaacgcccag cagcgcgggg

21301 tgtttggccg agtcctcacc gccttctccc gggaacctga caaccccaag gtgtgagacc

21361 ctgagggcgc aatggtaacc tgaagatagg gagagagggg aggactcgcg ctctccagcg

21421 gggcacacca accacggccc tcccgtggcc tcccacgacc actcagccac ccctgcacac

21481 tctggcccac ccttgtgccc cggcccctct aggccccgcc tcctcccgcc cctgccccgc

21541 ccctttggct ctgccctgtt gacaacgccc cagggcacgc aggccccacc aggcccgctc

21601 cggagaattt caaggtccag ggccagccag cagccccggg ctgcccccgc gcccaccccc

21661 accagggccc gccctaaccc cgccgccccg cagacctacg tgcaggacat cctgaggacg

21721 gagctggctg cggaggtgca ccgcgtgctg tgcctcgagc ggggccacat gtttgtctgc

21781 ggcgatgtta ccatggcaac caacgtcctg cagaccgtgc agcgcatcct ggcgacggag

21841 ggcgacatgg agctggacga ggccggcgac gtcatcggcg tgctgcgggt gcggaggggc

21901 gggccgggcc tgagcgtgcg gggttcctgc taaggtctcc gagtcgggtt ctgatccact

21961 gtgctctttt ccgacaggat cagcaacgct accacgaaga cattttcggg ctcacgctgc

22021 gcacccagga ggtgacaagc cgcatacgca cccagagctt ttccttgcag gagcgtcagt

22081 tgcggggcgc agtgccctgg gcgttcgacc ctcccggctc agacaccaac agcccctgag

22141 agccgcctgg ctttcccttc cagttccggg agagcggctg cccgactcag gtccgcccga

22201 ccaggatcag ccccgctcct cccctcttga ggtggtgcct tctcacatct gtccagaggc

22261 tgcaaggatt cagcattatt cctccaggaa ggagcaaaac gcctcttttc cctctctagg

22321 cctgttgcct cgggcctggg tccgccttaa tctggaaggc ccctcccagc agcggtaccc

22381 cagggcctac tgccacccgc ttcctgtttc ttagtcgaat gttagattcc tcttgcctct

22441 ctcaggagta tcttacctgt aaagtctaat ctctaaatca agtatttatt attgaagatt

22501 taccataagg gactgtgcca gatgttagga gaactactaa agtgcctacc ccagctcatg

22561 tggattacag tttttttttt ttgttttttt ttttttgaaa cggagtctcc ctctgccgcc

22621 cgggctggag tgcagtggcg tgatctcagc tcactgcaac ctccacccca caagttcaag

22681 tgattctcct gcctcagcct cccaagtagt tgggattaca ggtgcctgcc accgcgcccg

22741 gctaggtttt gtatttttag taaagacggg gtttcaccat cttggccagg ctggtcttga

22801 actcctgacc tcgtgatcca accgcctcag cctcccaaag tgctgggatt acaggtgtga

22861 gctactgcac ccggcgtgga ttacaattat aaaatgacaa gatttctgtt ttaacctgtg

22921 cagttgtggg tatgtggtgg ggaaaggggt cattctttta acagagtcct acacgccact

22981 tgaccctgca ctctgaaaac atggtttcca gccagtctgg gctgctcccc cgtgcagttc

23041 tcaggctcgt aatcgagaag gcaggtgcag cactcagctg ccaggagtgg ggcctgccag

23101 aaacaagagt cacagagatg tgcaacagcc atgagcaagc tt

(2) INFORMATION FOR SEQ ID NO: 33: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3690 base pairs

(B) TYPE: nucleic acid EPI-109 1182

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:33: I cagagtggac gcacagtaac atgggcaact tgaagagcgt ggcccaggag cctgggccac

61 cctgcggcct ggggctgggg ctgggccttg ggctgtgcgg caagcagggc ccagccaccc

121 cggcccctga gcccagccgg gccccagcat ccctactccc accagcgcca gaacacagcc

181 ccccgagctc cccgctaacc cagcccccag aggggcccaa gttccctcgt gtgaagaact

241 gggaggtggg gagcatcacc tatgacaccc tcagcgccca ggcgcagcag gatgggccct

301 gcaccccaag acgctgcctg ggctccctgg tatttccacg gaaactacag ggccggccct

361 cccccggccc cccggcccct gagcagctgc tgagtcaggc ccgggacttc atcaaccagt

421 actacagctc cattaagagg agcggctccc aggcccacga acagcggctt caagaggtgg

481 aagccgaggt ggcagccaca ggcacctacc agcttaggga gagcgagctg gtgttcgggg

541 ctaagcaggc ctggcgcaac gctccccgct gcgtgggccg gatccagtgg gggaagctgc

601 aggtgttcga tgcccgggac tgcaggtctg cacaggaaat gttcacctac atctgcaacc

661 acatcaagta tgccaccaac cggggcaacc ttcgctcggc catcacagtg ttcccgcagc

721 gctgccctgg ccgaggagac ttccgaatct ggaacagcca gctggtgcgc tacgcgggct

781 accggcagca ggacggctct gtgcgggggg acccagccaa cgtggagatc accgagctct

841 gcattcagca cggctggacc ccaggaaacg gtcgcttcga cgtgctgccc ctgctgctgc

901 aggccccaga tgagccccca gaactcttcc ttctgccccc cgagctggtc cttgaggtgc

961 ccctggagca ccccacgctg gagtggtttg cagccctggg cctgcgctgg tacgccctcc

1021 cggcagtgtc caacatgctg ctggaaattg ggggcctgga gttccccgca gcccccttca

1081 gtggctggta catgagcact gagatcggca cgaggaacct gtgtgaccct caccgctaca

1141 acatcctgga ggatgtggct gtctgcatgg acctggatac ccggaccacc tcgtccctgt

1201 ggaaagacaa ggcagcagtg gaaatcaacg tggccgtgct gcacagttac cagctagcca

1261 aagtcaccat cgtggaccac cacgccgcca cggcctcttt catgaagcac ctggagaatg

1321 agcagaaggc cagggggggc tgccctgcag actgggcctg gatcgtgccc cccatctcgg

1381 gcagcctcac tcctgttttc catcaggaga tggtcaacta tttcctgtcc ccggccttcc

1441 gctaccagcc agacccctgg aaggggagtg ccgccaaggg caccggcatc accaggaaga

1501 agacctttaa agaagtggcc aacgccgtga agatctccgc ctcgctcatg ggcacggtga

1561 tggcgaagcg agtgaaggcg acaatcctgt atggctccga gaccggccgg gcccagagct

1621 acgcacagca gctggggaga ctcttccgga aggcttttga tccccgggtc ctgtgtatgg

1681 atgagtatga cgtggtgtcc ctcgaacacg agacgctggt gctggtggta accagcacat

1741 ttgggaatgg ggatcccccg gagaatggag agagctttgc agctgccctg atggagatgt

1801 ccggccccta caacagctcc cctcggccgg aacagcacaa gagttataag atccgcttca

1861 acagcatctc ctgctcagac ccactggtgt cctcttggcg gcggaagagg aaggagtcca

1921 gtaacacaga cagtgcaggg gccctgggca ccctcaggtt ctgtgtgttc gggctcggct

1981 cccgggcata cccccacttc tgcgcctttg ctcgtgccgt ggacacacgg ctggaggaac

2041 tgggcgggga gcggctgctg cagctgggcc agggcgacga gctgtgcggc caggaggagg

2101 ccttccgagg ctgggcccag gctgccttcc aggccgcctg tgagaccttc tgtgtgggag

2161 aggatgccaa ggccgccgcc cgagacatct tcagccccaa acggagctgg aagcgccaga

2221 ggtaccggct gagcgcccag gccgagggcc tgcagttgct gccaggtctg atccacgtgc

2281 acaggcggaa gatgttccag gctacaatcc gctcagtgga aaacctgcaa agcagcaagt

2341 ccacgagggc caccatcctg gtgcgcctgg acaccggagg ccaggagggg ctgcagtacc

2401 agccggggga ccacataggt gtctgcccgc ccaaccggcc cggccttgtg gaggcgctgc

2461 tgagccgcgt ggaggacccg ccggcgccca ctgagcccgt ggcagtagag cagctggaga

2521 agggcagccc tggtggccct ccccccggct gggtgcggga cccccggctg cccccgtgca

2581 cgctgcgcca ggctctcacc ttcttcctgg acatcacctc cccacccagc cctcagctct

2641 tgcggctgct cagcaccttg gcagaagagc ccagggaaca gcaggagctg gaggccctca

2701 gccaggatcc ccgacgctac gaggagtgga agtggttccg ctgccccacg ctgctggagg

2761 tgctggagca gttcccgtcg gtggcgctgc ctgccccact gctcctcacc cagctgcctc

2821 tgctccagcc ccggtactac tcagtcagct cggcacccag cacccaccca ggagagatcc

2881 acctcactgt agctgtgctg gcatacagga ctcaggatgg gctgggcccc ctgcactatg

2941 gagtctgctc cacgtggcta agccagctca agcccggaga ccctgtgccc tgcttcatcc

3001 ggggggctcc ctccttccgg ctgccacccg atcccagctt gccctgcatt ctggtgggtc

3061 caggcactgg cattgccccc ttccggggat tctggcagga gcggctgcat gacattgaga

3121 gcaaagggct gcagcccact cccatgactt tggtgttcgg ctgccgatgc tcccaacttg

3181 accatctcta ccgcgacgag gtgcagaacg cccagcagcg cggggtgttt ggccgagtcc

3241 tcaccgcctt ctcccgggaa cctgacaacc ccaagaccta cgtgcaggac atcctgagga

3301 cggagctggc tgcggaggtg caccgcgtgc tgtgcctcga gcggggccac atgtttgtct

3361 gcggcgatgt taccatggca accaacgtcc tgcagaccgt gcagcgcatc ctggcgacgg

3421 agggcgacat ggagctggac gaggccggcg acgtcatcgg cgtgctgcgg gatcagcaac

3481 gctaccacga agacattttc gggctcacgc tgcgcaccca ggaggtgaca agccgcatac

3541 gcacccagag cttttccttg caggagcgtc agttgcgggg cgcagtgccc tgggcgttcg

3601 accctcccgg ctcagacacc aacagcccct gagagccgcc tggctttccc ttccagttcc

3661 gggagagcgg ctgcccgact caggtccgcc

(2) INFORMATION FOR SEQ ID NO: 34: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30417 base pairs EPI-109 1 183

( B ) TYPE : nucleic acid

( C) STRANDEDNESS : single

( D) TOPOLOGY : linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 34: 1 gggcccagag aaagagctgt ccccggggcc ttggggacag ggtgacagcc acccagagat

61 catggagaag gggacgtaag gaagacctca cagaggagtc atcctgcgac tgtgttggtt

121 gggtccttca ggaagcagag tcccaggagt tggaagcata agaggaatac tgcgggcaat

181 gcctgagaaa gataacaggg accgggagca ggagtgagtt gggcagggga aggatcaggc

241 ccacaatgcc aggctcacac ctgcagagga gggaagaaga agaagggcct cacatcagcc

301 cagcggggga tgttacgccc acagacgccc cggggctcag ttactgtcta agtgttagaa

361 ataaattttc ggtgccacaa aagaaatagc actcagatta aatgttccca gcaaggcaat

421 tttacttcta tagaagggtg catctcacag atggagcaat ggcaagagca cacctgaaca

481 agggaaggga aggggttttt atccctaagg caggtagccc ctacagctgt gttgttcccc

541 tattggctag ggttggacca caccgtctga gctaattgtt actggctatt ttaaagagag

601 caggggtaag agccggattg gcagggtaag tagtttggca ggaaggacgg tcacagaaca

661 ggtgactcag gatgactcag gtcagagcag gtgaccagtg gtgactcagt tcggagcagg

721 tgatagaagc taggaggggg ttgtttactg aaactagggg caaggagacg aagagaacat

781 gaaagttaaa ctttaagatg aagaacaaag ctgaacatac tgatgcattg gatctttgga

841 gaggatctca gaactcattg tacttaattt acaggctaaa accttagaag aggaatttat

901 tatatcctac acaagactcc agggaagcac atggccttgg actgaaggct ggcatctgga

961 agctgtcagc caccagcacc ttctgcagca ggtacctgct ctctaagagg gaggcctggg

1021 tggtgcacct ccagagctgc ccaggctggg cctcaaggaa gaaaaagatt ttcatttgtc

1081 agaggcggaa gggagaggtg gagggaacag cacagcagcg gcccaggggc agggaagcac

1141 aggaccatta gggagacacg agaaagccca tttgtctaga acagaggatt caagcagtgc

1201 accaaggaaa atgagggcca ggccaatgtg ctggagtggc tttgttcttg gctgagggtt

1261 ttgggtagtg ccaaagcgta aggtaagccc tgctttccag aagaatctag cagagtgtgg

1321 agcccagatg ggactggaag gcctgggagg ggtcaggtgg ccacagggac gggccacagc

1381 cagtggtgca ggcaagaaga caatggccat ccatggtggc tcacacctgg aatcccagcc

1441 cattgggagg tcgaggcagg tggatcacct gaggtcagga gttcgagacc agcctggtca

1501 acatggtgaa accctgtctc taataaaatt ataaaaatta gccgggcgtg gtggtgggta

1561 cctgtaatct cagctactca ggaggctggg tcaggagaat cgcttgaacc caggaggcgg

1621 aggttacagt gagctgagat agcaccattg cattccagcc tggacaacaa aagcgagact

1681 ctgtctcaaa aaaaaaaaaa aattagccag gcgtggtggt gggtgcctgt cgtcctcggg

1741 aggctgaggc atgagaatca ctccgggagg cagaggttgc aatgaaccaa gatcacacca

1801 ctgcactcca gcctgggtga cagagcaaga ctctgtctaa aaaaaaaaaa aagacagaag

1861 gatgtcagca tctgatgctg cctgtcacct tgaccctgag gatgccagtc acagctccat

1921 taactgggac ctaggaaaat gagtcatcct tggtcatgca catttcaaat ggtggcttaa

1981 tatggaagcc acacttggga tctgttgtct cctccagcat ggtagaagat gcctgaaaag

2041 taggggctgg atcccatccc etgcctcact gggaaggcga ggtggtgggg tggggtgggg

2101 cctcaggctt ggggtcatgg gacaaagccc aggctgaatg ccgcccttcc atctccctcc

2161 tcctgagaca ggggcagcag ggcacactag tgtccaggag cagcttatga ggccccttca

2221 ccctccgatc ctccaaaact ggcagacccc accttcttcg gtgtgacccc agagctctga

2281 gcacagcccg ttccttccgc ctgccggccc cccacccagg cccaccccaa ccttatcctc

2341 cactgctttt cagaggagtc tggccaacac aaatcctctt gtttgtttgt ctgtctgtct

2401 gctgctccta gtctctgcct ctcccagtct ctcagcttcc gtttctttct taaactttct

2461 ctcagtctct gaggtctcga aatcacgagg cttcgacccc tgtggaccag atgcccagct

2521 agtggccttt ctccagcccc tcagatggca cagaactaca aaccccagca tgcactctgg

2581 cctgaagtgc ctggagagtg ctggtgtacc ccacctgcat tctgggaact gtagtttccc

2641 tagtccccca tgctcccacc agggcatcaa gctcttccct ggccggctga ccctgcctca

2701 gccctagtct ctctgctgac ctgcggcccc gggaagcgtg cgtcactgaa tgacagggtg

2761 ggggtggagg cactggaagg cagcttcctg ctcttttgtg tcccccactt gagtcatggg

2821 ggtgtggggg ttccaggaaa ttggggctgg gaggggaagg gataccctaa tgtcagactc

2881 aaggacaaaa agtcactaca tccttgctgg gcctctatcc ccaagaaccc aaaaggactc

2941 aagggtgggg atccaggagt tcttgtatgt atggggggag gtgaaggaga gaacctgcat

3001 gaccctagag gtccctgtgg tcactgagag tgtgggctgc catcccctgc tacagaaacg

3061 gtgctcacct tctgcccaac cctccaggga aaggcacaca ggggtgaggc cgaaccttcc

3121 gtctggtgcc acatcacaga aggaccttta tgaccccctg gtggctctac cctgccactc

3181 cccaatgccc cagcccccat gctgcagccc cagggctctg ctggacacct gggctcccac

3241 ttatcagcct cagtcctcac agcggaaccc aggcgtccgg ccccccaccc ttcaggccag

3301 cgggcgtgga gctgaggctt tagagcctcc cagccgggct tgttcctgtc ccattgtgta

3361 tgggataggg gcggggcgag ggccagcact ggagagcccc ctcccactgc cccctcctct

3421 cggtcccctc cctcttccta aggaaaaggc cagggctctg ctggagcagg cagcagagtg

3481 gacgcacagt aacatgggca acttgaagag cgtggcccag gagcctgggc caccctgcgg

3541 cctggggctg gggctgggcc ttgggctgtg cggcaagcag ggccc ggatcccatg ccctgcctca ctgggaaggc gaggtggtgg ggtggggtgg ggcctcaggc

61 ttggggtcat gggacaaagc ccaggctgaa tgccgccctt ccatctccct cctcctgaga 121 caggggcagc agggcacact agtgtgcagg agcagcttat gaggcccctt caccctccat 181 cctccaaaac tggcagaccc caccttcttg gtgtgacccc agagctctga gcacagcccg 241 ttccttccgc ctgccggccc cccacccagg cccaccccaa ccttatcctc cactgctttt EPI-109 1184

301 cagaggagtc tggccaacac aaatcctctt gtttgtttgt ctgtctgtct gctgctccta 361 gtctctgcct ctcccagtct ctgagcttcc gtttctttct taaactttct ctcagtctct 421 gaggtctcga aatcacgagg cttcgacccc tgtggaccag atgcccagct agtggccttt 481 ctccagcccc tcagatgaca cagaactaca aaccccagca tgcactctgg cctgaagtgc 541 ctggagagtg ctggtgtacc ccacctgcat tctgggaact gtagtttccc tagtccccca 601 tgctcccacc agggcatcaa gctcttccct ggctggctga ccctgcctca gccctagtct 661 ctctgctgac tgcggccccg ggaagcgtgc gtcactgaat gacagggtgg gggtggaggc 721 actggaaggc agcttcctgc tcttttgtgt cccccacttg agtcatgggg gtgtgggggt 781 tccaggaaat tggggctggg aggggaaggg ataccctaat gtcagactca aggacaaaaa 841 gtcactacat ccttgctggg cctctatccc caagaaccca aaaggactca agggtgggga 901 tccaggagtt cttgtatgta tggggggagg tgaaggagag aacctgcatg accctagagg 961 tccctgtggt cactgagagt gtgggctgcc atcccctgct acagaaacgg tgctcacctt 1021 ctgcccaacc ctccagggaa aggcacacag gggtgagccg aaggcccttc cgtctggtgc 1081 cacatcacag aaggaccttt atgaccccct ggtggctcta ccctgccact ccccaatgcc 1141 ccagccccca tgctgcagcc ccagggctct gctggacacc tgggctccca cttatcagcc 1201 tcagtcctca eagcggaacc caggcgtecg gccccccacc ettcaggcea gcgggcgtgg 1261 agctgaggct ttagagcctc ccagccgggc ttgttcctgt cccattgtgt atgggatagg 1321 ggcggggcga gggccagcac tggagagccc cctcccactg ccccctcctc tcggtcccct 1381 ccctcttcct aaggaaaagg ccagggctct gctggagcag gcagcagagt ggacgcacag 1441 taacatgggc aacttgaaga gcgtggccca ggagcctggg ccaccctgcg gcctggggct 1501 ggggctgggc cttgggctgt gcggcaagca gggcccagcc accccggccc ctgagcccag 1561 ccgggcccca gcatccctac tcccaccagc gccagaacac aggtaagggc caggcagcta 1621 ggagcaggtg ggcaacaagg gtggtgteaa ggcctgaagc etggggctgg gaaggtctgg 1681 aacttgtagc tgagtcggga gggccaggtc acaaatgcaa aagggctatt aatgtgcata 1741 gaacaggaca gtctgggagg ctcagaaagg agaccaggat cagagtcggc aggtgaagct 1801 gggagtaagg gtgccagcta tagaatctgg ccagggtttg aatgctgctc tgccgccagg 1861 agctgtttga ctttgagcaa gttacttaat ctctctgaac ctccatttat ataaaacgag 1921 atatggcaat acttactcca tggggaagta agtttctagc tcacagcaag ccttcaacag 1981 cagcgatgat tatttagctg gagaagaaag gagctgacag cagtggttac aggagtgaga 2041 aagtggggtc tcccagaaga gggagagagt tgggcaggaa actcgggccc ttggggtaag 2101 caggctgaga agacagagcc aceaggcttt tttcccctgc tceagccecc tctcctcgtg 2161 gctgtcaccc gaaaactgga ccatgcagtt cccacaagag tcctcccggg ggtagaggtc 2221 ccaggaggga ggaaagaccc ggaggcctgg tggggtgcca ggccgggggc aggctggggc 2281 tgcaggcagc tatgcaggga aggctgaggg ccggggccct gctgctcagg cgcacccttg 2341 gcctgagtcc ctcccttcct ccctgccgct ggtggctctg ggaggaagtg ataaggcctg 2401 cgaggcttcc cttcacacat ggggctgctg tcaggagggg ttgtgagtgc ggagggaaat 2461 cagagctgag gaatccctgc agggcttccc tccactcaag caccaggctc tgtccccctc 2521 agggtagggc ttatagcagc tttgcggggg gtggacaccc catctccaga agaggtgagg 2581 tgggcgctgc aggtgggatg cgaacttagc ctcgggtcag gggctcagga gctcagcacc 2641 agcagcccct gcagcccagg accctggtct ataaacggag gcacagctcg cctctagctc 2701 etaaggcatg gggaacgcca gaaggcatgc ggcaggtggg etgtgagatc gceagtgctg 2761 taacaggggc ctccgggtga catctgggaa ggctgaaagg aaacaaaccc ttcctgatga 2821 ccctatccct ggctcccaac agccccccga gctccccgct aacccagccc ccagaggggc 2881 ccaagttccc tcgtgtgaag aactgggagg tggggagcat cacctatgac accctcagcg 2941 cccaggcgca gcaggtaagg ccggcatgcc ctgtccccat cgtctccagg gaaagggtgg 3001 gtaaggcctg gcctcagatg gggccggaga gggaagctca acccttcttt gaattggtcc 3061 cttgtttcca aaaagaggag aggactggga agaaccagag gagttgaggg acatgcacgg 3121 gacttgggtg accctcagcc tccagcctta cccccaaccc tggctcaaac ttttccccca 3181 tcccacccct gcaccccttt tccccctccc acccctgcac ccttcctccc tctcccccac 3241 cccacccctg ccccccctcc catcccagct ctaaacccct cctccctctc ccccgtccca 3301 cccctaaacc ccacctccct gtccccctct aaacccctcc tccctgtccc cctctaaacc 3361 ccacctccct ctccccatcc cacccctgca cccttcctcc ctctgccccc gtcccacgcc 3421 tgtactcctc ctccctctcc cccgtcacac ccctgcaccc ctcctccctc tccccatccc 3481 atccctgcac ccctcctccc tctgcccccg tcccacccct aaacccctcc tccctctgcc 3541 ccaccccacc cttgcacccc tcctccctct tcccccgtcc cctgcctgca ttcctcctcc 3601 ctctccccat ctcacccctg cacccctctt ccctctccca cccctgcacc cctcctccct 3661 ctccccgtcc caccctgcac tcccgccctc tccagcgtcc cacccctaca cccctcctcc 3721 ctctgcccca ttccacccct gcaccccctc ctccctctgc cccgacccac ccctgcaccc 3781 ctcctccctc tcccccgtcc cacccctgca tccctcctcc ctctgccccg tcccacccct 3841 acacccctcc tccctctccc ccatcccacc cctaaacccc tcctccctct cccctgtccc 3901 atccctgcac ccttcctccc tctccccgtc ccatccctgc acccttcctc cctctccccg 3961 tcccatccct gcacccctcc tccctctgct cccatcccac ccctgcaccc ctcctccctc 4021 tgcccctacc ccacctctgc acccctcctc cttctcccca tcccacccct gcacccctcc 4081 tccctctgcc cctaccccac ccctgcaccc ctcctccttc tccccatccc acctctgcac 4141 ccctcctccc tctcccctct cccacccctg tacccttcct ccttctcccc gtcccacccc 4201 tgcacttctc ctccctctaa cccatcccac ccctgcaccc ttcttccctc tcccccatcc 4261 caccactgca cccctcctcc ctctccccct gttccacccc tgcacccctc ctccctgccc 4321 ccaactccca tcccacccct gcaccctggc ctgtcctgac ctttgcactc cctcgaccca EPI-109 1185

4381 ggatgggccc tgcaccccaa gacgctgcct gggctccctg gtatttccac ggaaactaca

4441 gggccggccc tcccccggcc ccccggcccc tgagcagctg ctgagtcagg cccgggactt

4501 catcaaccag tactacagct ccattaagag gtgacagctt cccggacgcc acagcctccc

4561 ttgtcccact gaggccccag aaaccccgtg acgaccttcc catgaccccc tcccttccca

4621 gatcctaaca ccacgtgggc ccctcccgcc ctcccccagc acttgcacaa agcctggagg

4681 agggcctccc tgtcccacac aacttcctgc ttgtcccctt cccacccctc tcctccccag

4741 gagcggctcc caggcccacg aacagcggct tcaagaggtg gaagccgagg tggcagccac

4801 aggcacctac cagcttaggg agagcgagct ggtgttcggg gctaagcagg cctggcgcaa

4861 cgctccccgc tgcgtgggcc ggatccagtg ggggaagctg caggtgcggc tggccagcga

4921 ctgagagacc cgggcgctac caaaagggga gcggggtggc ggggcagttc ctaaggcttc

4981 ccgggggctg ggaggtceca aactgtgggg gagatccttg ccttttccct tagagactgg

5041 aaaggtaggg ggactgcccc accctcagca cccaggggaa cctcagccca gtagtgaaga

5101 cctggttatc aggccctatg gtagtgcctt ggctggagga ggggaaagaa gtctagacct

5161 gctgcagggg tgaggaagtc tagacctgct gcaggggtga ggaagtctag acctgctgca

5221 ggggtgagga agtctagacc tgctgcgggg gtgaggaagt ctagacctgc tgcgggggtg

5281 aggacagctg agcggagttc cctgggcggt gctgtcagta gcaggagcag cctcctggaa

5341 aagccctggc tgctgcttct cccccaagag agaaggcttc tcccgccagg ccagtccagt

5401 gcagcccctc acccacaccc actgctaccc cagttcccct gcttcggccc gcaccctccc

5461 tcacacccca gcceacagac tcggggctgg ccttagttac tggaacgcct gtgaccacag

5521 cactaagaga agcaagctgc cccatggggg acttggtccc catggccttg gcctccttca

5581 ccatcactgg ccgccaaaga gtttgaaata aagccacgtg cccagtgaat cccaaaggaa

5641 cctcaactaa aataaaaaca atcctatctg acacttgcct gaccctctaa gtcattcaaa

5701 gctttagctc aacttcgatc catctgagct gccatagtgg accccactca gagctgcgtc

5761 ecteccttga ecccaggttg gtccctgcca ctcccctgcc cetgtcactg acacatgttt

5821 cctcctccct caggcaggag tgggacctcc cagcctcctc ctggggcctc cactcagaat

5881 gtcaggatga gcagggtcct aggaggcctc tggtgcagcc ttcccttccc accatccatg

5941 tgctcaaaga gaatcacccg tcctttcttg aatgccatgg atcatggggg atttgctgcc

6001 cacactccta ggcggcctct tagacatccg ttggtgccta acccaagcat cagtttggca

6061 gaggccgagt ccctcctctg tactggatac caagtcagct tccataggga tggggagaca

6121 cctggcccag ggaggagatg agaagcagcc cggatggtgc tacatatgtc agagagcagg

6181 gcaggaaggg atcagtgtgg ctgccaatgg tcaggagggc gccatggagt gaaccatggc

6241 ccctgcctcc tcaaccaaga agtcctctgg agctgatact caagaccccc cgtctctctc

6301 ctcaccctcc tctcccgctg cctcggctgg ctcaggtgtt cgatgcccgg gactgcaggt

6361 ctgcacagga aatgttcacc tacatctgca accacatcaa gtatgccacc aaccggggca

6421 accttcggtg agtgcccccc accatgccag gccccagcct tcttccccaa ggcagggaag

6481 gcggggctct gaccagctct ttccccatgc gtgccagctc ggccatcaca gtgttcccgc

6541 agcgctgccc tggccgagga gacttccgaa tctggaacag ccagctggtg cgctacgcgg

6601 gctaccggca gcaggacggc tctgtgcggg gggacccagc caacgtggag atcaccgagg

6661 tgggcaccga gggccaccca tgagggtgtc cccaaggtgg agaatgagga aaccagtggg

6721 agaaggctcg ggggatccag gcaggaagag gggagcctcg gtgagataaa ggatgaaaaa

6781 caccaaagga ggggtgcctg ggtggtcacg gagacccagc caatgaggga ccctggagat

6841 gaaggcagga gacagtggat ggaggggtcc ctgaggaggg catgaggctc agccccagaa

6901 ccccctctgg cccactcccc acagctctgc attcagcacg gctggacccc aggaaacggt

6961 cgcttcgacg tgctgcccct gctgctgcag gccccagatg agcccccaga actcttcctt

7021 ctgccccccg agctggtcct tgaggtgccc ctggagcacc ccacgtgagc accaaaggga

7081 ttgactgggt gggatggagg gggccatccc tgagcctctc aagaagggcc tgcaaggggg

7141 tgctgatccc acaccccaac acccccaggc tggagtggtt tgcagccctg ggcctgcgct

7201 ggtacgccct cccggcagtg tccaacatgc tgctggaaat tgggggcctg gagttccccg

7261 cagccccctt cagtggctgg tacatgagca ctgagatcgg cacgaggaac ctgtgtgacc

7321 ctcaccgcta caacatcctg gaggtgaggt gcgggatggg gctcgggcac cgaatgcacc

7381 tgtccaaggc aggagtctgg ctctcactcc atccccaaaa tgccagccac ggggacaatc

7441 agagcaggtc cagggttgcc tcctaaatgg gaactgagga caagctctag aaccactgaa

7501 gcaaaggggt agggggtggc aggggtgtgt gtgggggtgt gagtgggtga gtgtgagagt

7561 gtgggtttct ggggtgtgca gtgggtgaga gtgtgggctt gtggggtgtg tagtgggtgt

7621 gagactgtgg gtttgtaggg gtgggtgagt gtgggtgtgt gggggtaggt gggtgtgggt

7681 ttgtgggtgt gtataggcag tgactgtgag actgtgggtt tgtgggggta ggtgactgtg

7741 ggtttgtggg gtgtgtaggg gtgagtgtgt gtgggtttgt aggggtaggc gagtgtgggt

7801 ttgtggggtg tgtaggggtg agtgtgtgtg agtttgtagg ggtaggcgag tgtgggtttg

7861 tggggtgtgt aggggtgagt gtgtgtgagt ttgtaggggt aggtgagtgt gggtttgtgg

7921 ggtgtgtagg gggtgtgtgt gggcttgtag gggtaggcga gtgtgggttt gtggggtgtg

7981 taggggcgag tgtgagagtg taggtatgtg ggtgtgagtg tggatgtgtg taggcggtga

8041 gtgtgaaatt gtgggtttgt gggggtgggt gggtgtgagt gtgtgggttt gtgggtgggt

8101 gtgggtgtga gtgggtgggt gaggggggca tggggatggg tgtgaacatg tagttgttct

8161 ttcaggcata ggacccatag ctctagagct ttcatcagat tctcaaaggg gaccttgact

8221 cggaaaaggt taagacccat tttagagatg agaaattaaa gcctggagct gaggagcgac

8281 tggcccaaag tccctctctg ctctgaggtg cttcgcaggc aaaaacctga accagccccc

8341 taggcagcca ggcctcccaa tggacaccac tcacctcact ccttccagcc atgtacggga

8401 aacagagata gtctccccac cccacccccg tgatcacctc tgtccctacc gatgccacac EPI-109 1 186

8461 cccaggatgt ggctgtctgc atggacctgg atacccggac cacctcgtcc

8521 ctgtggaaag acaaggcagc agtggaaatc aacgtggccg tgctgcacag ttaccaggtg

8581 cagaggccca gactggccag gaaggcaaag ggtttgcata cgggggcagc aggggcgggg

8641 gatggaggag aggcagccat ttagaaacta gggcaggatt tggacaggca gaagaagttc

8701 cgtagtccca gtgccatggc gcacactggc tgcggttcgg ggacagggca ggtactattc

8761 caggcgctgt catctggtgg cttactgtgt gccagggacc ttgctgttta ctgcatgccc

8821 agtcatgctg attctcaggg catattgggt attgcagttt gtgggacccg ctggatcctg

8881 gaaacaaata ccaggatcaa gggcacacca ggagtcgtag tttgaggaag ccggggcctg

8941 ctgagaattt ctgtgggcta tttggtttgg ggaccaggca tgcagatgct ggagattaga

9001 gctgcttgtt gcatgttgaa cctgcagcat gaccatgcat gatgtggttt ggggtgaggg

9061 tgacattgtg gtttgagggg acacagggtg tgttagatat ggggtaatcg agggcacatg

9121 tggtttgggg tgaccggagt ggtggaggaa gaatgggcga ggtctgtggg tctggtttga

9181 gcctctcccc ctctctctcc cttccagcta gccaaagtca ccatcgtgga ccaccacgcc

9241 gccacggcct ctttcatgaa gcacctggag aatgagcaga aggccagggg gggctgccct

9301 gcagactggg cctggatcgt gccccccatc tcgggcagcc tcactcctgt tttccatcag

9361 gagatggtca actatttcct gtccccggcc ttccgctacc aggtgcccac cctaatggct

9421 ctgccagcct gggcccagct ctaattctaa gcagcccctg gggacctcta acctttcctt

9481 ttctttacct cccctcccaa ccccatcatc tctctgcagc cagacccctg gaaggggagt

9541 gccgccaagg gcaccggcat caccaggaag aagaccttta aagaagtggc caagtgggtc

9601 ccctgggagc cccgctctcc cacacacacc ctgggggccc cactctcccc cacacaccct

9661 gggggaccct gccccagcag tgttctggac ctaccactca gtatcccaaa accctgttgt

9721 gagggggttg gacccttgcc tggggaggcc ctgcctctgt gcacccggga caccctcaca

9781 ccttcctctc ccgcagcgcc gtgaagatct ccgcctcgct catgggcacg gtgatggcga

9841 agcgagtgaa ggcgacaatc ctgtatggct ccgagaccgg ccgggcccag agctacgcac

9901 agcagctggg gagactcttc cggaaggctt ttgatccccg ggtagggctg agcccagggg

9961 agcagggagc tagaaagagg gggctctatc agcatcttca ggggtgccct ggaggacagg

10021 aagtgttaca agtcaggact catgaggaac ccggaaccac aggtgttcag agatcaagtt

10081 ggggcctgaa tcttgcactg ccagggaggc cagagtgagg agggcagggc ctccgggggc

10141 cacagcaccc aggacatctg tcttcccacc cacaggtcct gtgtatggat gagtatgacg

10201 tggtgtccct cgaacacgag acgctggtgc tggtggtaac cagcacattt gggaatgggg

10261 atcccccgga gaatggagag gtgagaactt ccaggaaagg ggctgctggg aatgaggaga

10321 gactcagaat tggagtgact gggcaggaac ctctgcccaa cacacacaca cacacacaca

10381 cacacacaca cacacacaca cacacacaca cacacacaca cacacacaca cgccaggatg

10441 gaaagggaga tgctaagaga cccctggagc ctgaaacccc acacaacgta cgctcccagc

10501 ccacccatgt ggctgcctcc ctgcaagcac atttgcttaa ctgcgcgtcc ccaagtcatt

10561 tccattatca gtgcaagttt ttaatacaag gaaggcacat cctggctgac caagaggtta

10621 gactgtgctc gggcactgac aagaaaaaca gggatacgtc actgagggcg gcttctagga

10681 tgcgggtaat gtttcttaat gggatactgg ttacacaggt gtgttcagtt tgtaaaaatc

10741 cacagagctg tacatttaca acatgtacaa cactattcca gcattttatt ttatttgttt

10801 tatttatttt gataacctat ttacgttgcc caggctggcc ttgaactcct agcctcaaga

10861 gatcctcctg ccgcaggctc ctttttcaaa agaagaaatt gagcgctgtt tagatgccaa

10921 catagattaa ataacttcac tttttaaaaa gaaacacaaa gctagagtac catcattgaa

10981 ttccttctct tgcaagctta ggtatctctg aggtgcccca ggctaggctc atttctgagt

11041 cttacctgct ccagcttcta ggtgttaaag gccttattag cactaagtac ttcctcagta

11101 ctcttttttc ttttttcctt tgagacaggg tctcactttg tggcccaggc tggagtgcag

11161 tagtacaatc acggctcact gcagcctcaa cctcctagac tcaagcaatc ctcccacttc

11221 aacctcccaa gtagttggga ctacaggcgc atgccatgat gcctagctaa tttttgtatt

11281 ttttatagag atggggtttc gccatgttgc ccaggctggt ctctaactcc tgggttcaag

11341 caatccacct gcctcggcct cccaaagtgc tgcgattata gacgtgagcc actgcacctg

11401 gcccgcagta tcttaagcaa gttggaatct cgtgaaaccc tttttgctgc cttagtgtcc

11461 gtttcagccc tcattcttac ctaccttttc aagaaaaata gcaccagcaa ttgacttttt

11521 tttagcataa aggtgtatag aacccatata acctacagcc ttcacaaggc atagcacatt

11581 ttcaccaccc tggaaagttc cctcatcagt tcctcacgtg aatcccttcc cagtctgtct

11641 ccctgccaga agtgtctgtc accacagaat agtttcgcct gctctagaac ggcacctaga

11701 tggaagcacg cagtgttgcg gcgtctcctg ctgaggctgt ttttgaggcg cactcgtgtt

11761 gctgcgtgac tcagtatttc actcattctg ctgctgagtg ccgttcattg tgtgaatatc

11821 cccagtttgt ttacccattc tcttgttggt gacacttggg ctgtttccag gtcggggcta

11881 ttatgaataa acctgttatg aacattctgt acccggcttt tgtgggctta tgtttttatt

11941 tctcttgggt aaaacctagg agtagaattg gtaggtcata gggtagatgc atgtttaatc

12001 tttcactttt ttaaaaaata aaactgccag gccaggcgcg gctgctcacg cctgtgatcc

12061 cagcactttg ggaggcccag gtgggtggat cacttgaggt cagaagctca agaccagcct

12121 ggccaacatg gcaaaaccct gtctctacta aaaatacaaa aattagctgg gcatggtggc

12181 gcacgcctat agtcctagct actcaggagg ctaggcggga gaattgcttg aacctgggag

12241 gtggaggttg cagtgagccg agatcacgcc actgcactcc agcctgggtg acagagcaag

12301 aattctactt aaaataaaat acaaataaat aaaataaaac tgtcaaacag caaagcaaat

12361 taaactgccc tttaacatct gtgcagttca atgtatgtta attttatccc aaatttttaa

12421 caaatctagg aatacagctc acagaaaatg gggtatattc actaaaaata aggaatattt

12481 atagcaaatt tgtttgtaat accccacact ggaaacaatt caaatgacca tcgacaaata EPI-109 1187

12541 ctgataaatt gtggtatatt caagtgccat atcgcactaa gtgtgaacga aacacaacca 12601 cacacaacag tgcaggtgaa tctgaaaaaa tgtgaagaga agaaaaagcc agaccaaaga 12661 atacatactg tactacaggg ttcactttat ataaagttca gaaacaggca gaactaatcc 12721 acggagttag aaattaggag aggagttagt cactgggatg ggggtggcag tgacaggaag 12781 aaggcacgaa gttggcttct aggatgcggg taatgtttgt ttgtttgttt gtttgtttgt 12841 ttttgttttt gagctggagt ctcactctgt tgcccaggct ggagtgcaat ggcgtgatct 12901 cggctcactg caacctccgc ctccccggtt caagcgattc tcctgcctca gcctcccgag 12961 tagctgggat tacaggtgcc cgccaccatg gccagctaat ttttgtgttt ttagtagaga 13021 cgcgtttcac catgttggcc aggctggtct tgaatccctg acctcagcct cccaaagtgc 13081 tgggattaca ggcgtgagcc accacgccca gccacgggta atgtttctcg atgggatgct 13141 ggttgcacag gtgtgttcag tttgtgaaaa cttacagagt tgtacattta caacatgtgt 13201 gcacctctgg acttgtgttg cacgttgaca aaacattcaa aaatgaaatt caaatcgttc 13261 ttgctaactc tggcgcactt gggaaccagc acccagaggc atctgcagtt gagcaccaga 13321 tgcagttcct tccagcttcc ttccccctgg gaggtccgct tgatgccact tcttcatggc 13381 agcacaaaca aggccatggt cttctgagga gggcaacctg cacaatgtct gctagtgacc 13441 aggacactgc tgaaggaact gagagtttgt ccacccatga aatccactaa aacaggaaag 13501 attttgctct agccgttgtt agccaggagt gaggaaagag ctgtgccctc ccctgcagct 13561 gcgaggacga tctgcctgcc ccaacaagtg gggattcagc aactccactt ctaaggatta 13621 cccagctgaa gcatttaaaa gtgggagcaa ggcacacgta caagggcgtt tgagagagca 13681 cctgttccca gaccaccgag ctgcccttca gtctcagtga agtacaatgt agccactaaa 13741 aagactgagg tcatgttttg gaaagtccag gccggaggat cgcttgagcc caggagttca 13801 aggccagact gaacaacaca gcgagactcc atctcttcag aaaatttaaa aattaaccaa 13861 gagtggtggc acgcacctat agatctagct actaggaagg cagaaaaatc ccttaagccc

13921 aggagtttga ggttacagtg aatgatgatg gagccactgc accccaacct gggcgacaga 13981 gcaagaccca tatctaaaaa caatactact acttacgtca atattgttgt attgacctgg 14041 agggatgtct gcaataaatt attgattaaa accaaggaag tacagtatgg taccactttt 14101 acttaaaaaa aaactataaa tatgcacgtg cacgtaagtt caaggaaaaa gggctggaag 14161 gttaacacct gtgaatggcg catatgcccg gaggaagatg gggtggtctt tgtcttatca 14221 ctttacacat ttctgtaatg tcatttttca aaaacatcag atcgcttttg aaattttcaa 14281 aacaaataaa aattaagtga caaatcaata ataatgagga tcagctggta cagttttaaa 14341 cttctatgta gtttgaaatg aaacaaaact aaccctgatg caaacactcc cctcgccaga 14401 gctttgcagc tgccctgatg gagatgtccg gcccctacaa cagctcccct cggccggaac 14461 agcacaagtg agttgggtga gagtttgggg gagctggggg agctgatgca tttggagaca 14521 caaacagaaa gggggtctga aaagctctcc ctctgtgcct caagtcgttt tcccaccaaa 14581 agccagggct ccaggatgcc ctccattcca ggctgcaatg gcagtccaga cctgcctgct 14641 tctgagagcc gggacagtcc tgaggtcttc agagatgggg gtgtggtgtg tcagggcccc 14701 aggctcggaa ccccagggat gctggccctc agcccctccc aagggcaggg cctttcctgt 14761 ccagaggcag agaccctgaa gccgtccctg gggctgggtc tgggcctagc ctgtatcccc 14821 agggccctgt gacaaccttg tctttgtcct ctcttgccag gagttataag atccgcttca 14881 acagcatctc ctgctcagac ccactggtgt cctcttggcg gcggaagagg aaggagtcca

14941 gtaacacaga cagtgcaggg gccctgggca ccctcaggtc agggcctcac caagaggggt 15001 gcaacgggtg ggcaagctgc ctgggcaaac gtggcctgca aagggagctc cactgacgac 15061 ccctgcaccc caggttctgt gtgttcgggc tcggctcccg ggcatacccc cacttctgcg 15121 cctttgctcg tgcggtggac acacggctgg aggaactggg cggggagcgg ctgctgcagc 15181 tgggccaggg cgacgagctg tgcggccagg aggaggcctt ccgaggctgg gcccaggctg 15241 ccttccaggt gagcccagcc cagcccctgc tctgactcct gccccctggg atgcctcctc 15301 etgcctcact ctgccctgat tctgtttggt tctttggtcc cttcctgttc cttccaaaat 15361 ccaccctcat ctctccatgg catagccagc tcttctgggt caggggcaga ggatgacatg 15421 gccctgccga ccacaggggt gcctagccca ggcagaagtg cagccgaaag agagcaggca 15481 gggccctggc aggagggagc ttcagccagg cacaggctgg gcctcacaag tgggcgcaca 15541 aagggagggg gtgcagggca gggcagggga ccccacccag gatgggcagg atggagggag 15601 aaggaaggga cagagagaag gtcagacaga ggcaagggct gaagctgagg ccagcacaga 15661 agccacagga agccagaggc cagacagcct ggggcggtgc ctgcaccaga actggtccgg 15721 gccaggcaag caagcacagg gagaggtgga tccctggggg ctgtggcttt ttaagcctgg 15781 gcttcctcag gggcagtgct gcctgtctgg ggatcatgtc tgcagttgac aagggctcgg 15841 tctccccagt gccacactgt tcagggcagt gctgctgtcc cggggcccag gctggagctc 15901 agcagatttg ccttgattgg aggaggaggg catcctagga ggagagggag tgggggctac 15961 ctcagggacg gggaggtcag gctgcagaaa cacataggcc ctgattggga agaagggaca 16021 cggtaaaata agctctaaaa gaatttaaaa caaaaagagc cattgcagcg ggatgagacc 16081 acatcatcag gttttgggaa taggacttta gaggcgtagg atccattaca gcatcaccga 16141 accagaagca ggaaggctga gctaagcaga gcagcagcag tggagatagg aaggaaggga 16201 gggaggggcc gaggaaggaa ggaagagata taagacttca cacgcaccac aaaagaaaga 16261 ttaacgggac ttggtgatat gaggctcagc caatcacggg tgagccctgc atttcaagcc 16321 tgggactggc ccagcagttt tccagctgtg tgcctgacca ggagtagacg ggatccacac 16381 cctcccaggg atctgccccg tggggtcccc tctgccgccc gaattgtgcg tcccttccca 16441 ggagcactta ctatctgcac gcactttgtg gaaagctaag ggctttacat aaagtatctc 16501 atttaatctt caccagaaca caatgaggtg taaagatggg gaaactgagg catgtcactg 16561 taagtacggg attcggaatt tgaatgcagg tctgaacaca cagacgcctt cacagagcta EPI-109 115

16621 ccgtgtgcca agcactatgc ttctcggatc acgggattaa cacgcaccag ataaggaacg 16681 atgcaccaat caggacgtgc agagaaagag ccagccgggt ccctgggccc agcggccaat 16741 ccatgaaatg ggctggcgga aaaggtgctg tccttggcgc cggcctcagc cactggggct 16801 gccaaccccc caggagcaag acgcagtgaa gccgcccagg cgcctcacta gggcgacccc 16861 tggtggcggg aggtcctcag ccctcaccgg cctgtcccgc aggccgcctg tgagaccttc 16921 tgtgtgggag aggatgccaa ggccgccgcc cgagacatct tcagccccaa acggagctgg 16981 aagcgccaga ggtaccggct gagcgcccag gccgagggcc tgcagttgct gccaggtggg 17041 ccctgcctca ccctaacccg gctggttctc tgaggccccc acaccccggg actaaagcac 17101 tctggggcca ggccctgctc cctagctcag gctgcctcat ttgcccctcc ccgcccccag 17161 gtctgatcca cgtgcacagg cggaagatgt tccaggctac aatccgctca gtggaaaacc 17221 tgcaaagcag caagtccacg tgaggacgac ggctttaccg ccccccaacc cctgtcctga 17281 acaccctgac cctggaccct cctcctccca cattctcccg cccccacccc tctctgactc 17341 cccataagtg cccctctccc cacccccagg agggccacca tcctggtgcg cctggacacc 17401 ggaggccagg aggggctgca gtaccagccg ggggaccaca taggtgtctg cccgcccaac 17461 cggcccggcc ttgtggaggc gctgctgagc cgcgtggagg acccgccggc gcccactgag 17521 cccgtggcag tagagcagct ggagaagggc agccctggtg aggggcagcc tgggaagcaa 17581 cagggcacac cagccccatg cccagcccca cccccggccc caggcctcca ggagctcagg 17641 acccgaccca gggggtggcc acctcctcca cagctcagca ggcaggctca gagctggctg 17701 tgctgcccac tgccgggctg gccttgttgc tggaccatcc ccacaccctc aaatgcaccc 17761 ccaccaaaag gctgtcccct ccctctgggc tcctctccaa ggctccccta gcaatctagc 17821 ttgctctgga gctggcactg gggctatttg ctgccacatc aatgcctggg ctttatttaa 17881 aataaggggg tggagtcaga ggcagaggag cccagaccaa cccagtccgg ccaggggccc 17941 ccgaacaata cactgaggct acctagacag gccgaccccg ctgctcaagg gcaggctctc 18001 taacagtcac caaaacacaa acatcagccc aggtactgca gtcctgctgg gccctgtcct 18061 cagagctccc tgtgcactat ccccaggtgg ccctcccccc ggctgggtgc gggacccccg 18121 gctgcccccg tgcacgctgc gccaggctct caccttcttc ctggacatca cctccccacc 18181 cagccctcag ctcttgcggc tgctcagcac cttggcagaa gagcccaggg aacagcagga 18241 gctggaggcc ctcagccagg ttgggggcca ccccaatgag gcacaggggc tagagagacg 18301 ggatgagctg gggggacccc agtggcagga aacccccatg caaagtcccc cctggacttt 18361 cttctcctgg ctgacatgca ctggtgcttt aagacccagc tcctcaggga ggaattcatg 18421 gctggattct ccaggtctta gagaaaactc tattggcctg aactgagcag ggagaaaccc 18481 taaagaggct cagtggggga ggggtcaaga agggaggtta ctaggaaggg ctatggggcc 18541 tccaacccac tgcatcctgc cccgccagga tccccgacgc tacgaggagt ggaagtggtt 18601 ccgctgcccc acgctgctgg aggtgctgga gcagttcccg tcggtggcgc tgcctgcccc 18661 actgctcctc acccagctgc ctctgctcca gccccggtac tactcagtca gctcggcacc 18721 cagcacccac ccaggagaga tccacctcac tgtagctgtg ctggcataca ggactcaggg 18781 tgaggcaaca agcaggagca ggcctggcca cagcagggtt gggaccggcc cctctctggc 18841 ccctcaccgg cctctccttc ccacccccag atgggctggg ccccctgcac tatggagtct 18901 gctccacgtg gctaagccag ctcaagcccg gagaccctgt gccctgcttc atccgggggt 18961 aagtgagatg gaggacttgg tggggagctg cccagggtca gggtggcagc tttggtgagg 19021 agtgtcactg gtgaggggtg tcactggaaa caggaaggag ctctgtaaca tgtcaagggt 19081 gtggtgtcat taggtcactt cagaactctg gctaagcttt ggctctctca ttcatttaga 19141 ctcagagttc tgccctgaaa ctatagctcc cagagccaga gctggtatca aaccggctgg 19201 ccctgtggct ttctgaaagc ttctgtgttc ctctctatgt ccctgggctg tctgatgttg 19261 ggcagcatgg cacctgggaa ctacagtcac taaatcctca ctcaatccag ggagaactac 19321 tagttagggt taagaccacc ctttggcctt ggtgtcacca aggactcaaa gaaggtgaag 19381 gttttggttt ttttttcccc cagagatgga gtcttgctct gtcgcccagg ctggagtgca 19441 gtggtacgat ctcggcttac tgcaacctcc gcctcccggg ttcaagagat tctcctatgg 19501 cgtgaacctg ggaggtggag cttgcagtga gccaagattg tcccactgca ctccagcctg 19561 ggcgacagag ccagactctg tctcaaaaaa aaaaaaaaaa tattctcctg tctcagcctc 19621 ctgagtagct gggattacag gcacccacca ccacgcccag ctaatttttg tatttttagt 19681 agagacggtg tttcactatg ttggccaggc tggtctcgag ctcctgacct cacaatcctc 19741 ccacctccgc ctcccaaagt cttgggatta caggtgtgag ccaccgcgcc cggaccgagg 19801 gtgaaggatt ttaagagacc cttccttcat gctgtgtcca gaagtcttgc ccgctctcgc 19861 agccaggaac caaaagtcct ggtaggactg agaacagttc ctaggctgcc atcagctggg 19921 cctggtgatt caaatccacc caggtggcta aactacaaat aaaccgtacc catctactga 19981 acataaacta aataccacta ttaaggatac ttaaaataaa cacacttagt gaacccatta 20041 tgaactgaaa gtgtctttca cccttcccac gttttctaaa tcccctgagt catctaagta 20101 ttcttcaatc caaaatgaac tatatttcct ttggtgcaat ctccagaaac cacagatcca 20161 aggagtttca gcaagtagag ttgttttttg ttttttgttt tttttttaat ttttttttga 20221 gatgggaaga acttgggtcc tccttgctcc acccaccctg catggtgaga atggtggagc 20281 aggaaaggca aaggggacct gatggagtgt ctctcctgcc agggctccct ccttccggct 20341 gccacccgat cccagcttgc cctgcatcct ggtgggtcca ggcactggca ttgccccctt 20401 ccggggattc tggcaggagc ggctgcatga cattgagagc aaaggtgagg ctggtgacta 20461 aaggactgcc tgaagggagt cacacaatct agggacagag gggtggggct ggaaggcagg 20521 aaataggaaa gagagggcag gaaacaaagt ccacaaagct gaaaagacgc tcatgagacc 20581 aaggggaggg caggtaccaa aggcaagggc tgggccctga gcttctggct tcctggtgcc 20641 tggtacatag taggtgttga ctggattgag gacaaaggaa aatagaattt tcaaagggat EPI-109 1189

20701 tagggctaaσ actcaaagaa gaactgccca aggtggattc ttgactgtgc cagagctgac 20761 cgaggtctgt ccaagaccta aggatgctac aaggtgttca tattgagcat ggggtgccca 20821 gggtggtctg tcaatcaaaa gaagagggct gtgactggga ggagagttat aagtatggga 20881 gaatatgaag tgggagcggg gaaggggact gcgatgtcac acaatgcaaa gggcatggaa 20941 ttctgagtcc gaagccgcgc attctagcgc actccaccag gggccaccac ctcacccgcg 21001 cttcccttcc ctctgtaaat cagggctgtg cagggtctct gtgaaagcat tctacactct 21061 cttagagatg aaacagccaa agtaatggtg gtttcagccc aaaacgctgg gctgccaggc 21121 tgggcgacgg tggcctσtgg ggaggcccca ctagcactgt gccccggaga agagccttcc 21181 caagcgcggg gttgcttgca gggctgcagc ccactcccat gactttggtg ttcggctgcc 21241 gatgctccca acttgaccat ctctaccgcg acgaggtgca gaacgcccag cagcgcgggg 21301 tgtttggccg agtcctcacc gccttctccc gggaacctga caaccccaag gtgtgagacc 21361 ctgagggcgc aatggtaacc tgaagatagg gagagagggg aggactcgcg ctctccagcg 21421 gggcacacca accacggccc tcccgtggcc tcccacgacc actcagccac ccctgcacac 21481 tctggcccac ccttgtgccc cggcccctct aggccccgcc tcctcccgcc cctgccccgc 21541 ccctttggct ctgccctgtt gacaacgccc cagggcacgc aggccccacc aggcccgctc 21601 cggagaattt caaggtccag ggccagccag cagccccggg ctgcccccgc gcccaccccc 21661 accagggccc gccctaaccc cgccgccccg cagacctacg tgcaggacat cctgaggacg 21721 gagctggctg cggaggtgca ccgcgtgctg tgcctcgagc ggggccacat gtttgtctgc 21781 ggcgatgtta ccatggcaac caacgtcctg cagaccgtgc agcgcatcct ggcgacggag 21841 ggcgacatgg agctggacga ggccggcgac gtcatcggcg tgctgcgggt gcggaggggc 21901 gggccgggcc tgagcgtgcg gggttcctgc taaggtctcc gagtcgggtt ctgatccact 21961 gtgctctttt ccgacaggat cagcaacgct accacgaaga cattttcggg ctcacgctgc 22021 gcacccagga ggtgacaagc cgcatacgca cccagagctt ttccttgcag gagcgtcagt 22081 tgcggggcgc agtgccctgg gcgttcgacc ctcccggctc agacaccaac agcccctgag 22141 agccgcctgg ctttcccttc cagttccggg agagcggctg cccgactcag gtccgcccga 22201 ccaggatcag ccccgctcct cccctcttga ggtggtgcct tctcacatct gtccagaggc 22261 tgcaaggatt cagcattatt cctccaggaa ggagcaaaac gcctcttttc cctctctagg 22321 cctgttgcct cgggcctggg tccgccttaa tctggaaggc ccctcccagc agcggtaccc 22381 cagggcctac tgccacccgc ttcctgtttc ttagtcgaat gttagattcc tcttgcctct 22441 ctcaggagta tcttacctgt aaagtctaat ctctaaatca agtatttatt attgaagatt 22501 taccataagg gactgtgcca gatgttagga gaactactaa agtgcctacc ccagctcatg 22561 tggattacag tttttttttt ttgttttttt ttttttgaaa cggagtctcc ctctgccgcc 22621 cgggctggag tgcagtggcg tgatctcagc tcactgcaac ctccacccca caagttcaag 22681 tgattctcct gcctcagcct cccaagtagt tgggattaca ggtgcctgcc accgcgcccg 22741 gctaggtttt gtatttttag taaagacggg gtttcaccat cttggccagg ctggtcttga 22801 actcctgacc tcgtgatcca accgcctcag cctcccaaag tgctgggatt acaggtgtga 22861 gctactgcac ccggcgtgga ttacaattat aaaatgacaa gatttctgtt ttaacctgtg 22921 cagttgtggg tatgtggtgg ggaaaggggt cattctttta acagagtcct acacgccact 22981 tgaccctgca ctctgaaaac atggtttcca gccagtctgg gctgctcccc cgtgcagttc 23041 tcaggctcgt aatcgagaag gcaggtgcag cactcagctg ccaggagtgg ggcctgccag 23101 aaacaagagt cacagagatg tgcaacagcc atgagcaagc tt cagagtggac gcacagtaac atgggcaact tgaagagcgt ggcccaggag cctgggccac

61 cctgcggcct ggggctgggg ctgggccttg ggctgtgcgg caagcagggc ccagccaccc

121 cggcccctga gcccagccgg gccccagcat ccctactccc accagcgcca gaacacagcc

181 ccccgagctc cccgctaacc cagcccccag aggggcccaa gttccctcgt gtgaagaact

241 gggaggtggg gagcatcacc tatgacaccc tcagcgccca ggcgcagcag gatgggccct

301 gcaccccaag acgctgcctg ggctccctgg tatttccacg gaaactacag ggccggccct

361 cccccggccc cccggcccct gagcagctgc tgagtcaggc ccgggacttc atcaaccagt

421 actacagctc cattaagagg agcggctccc aggcccacga acagcggctt caagaggtgg

481 aagccgaggt ggcagccaca ggcacctacc agcttaggga gagcgagctg gtgttcgggg

541 ctaagcaggc ctggcgcaac gctccccgct gcgtgggccg gatccagtgg gggaagctgc

601 aggtgttcga tgcccgggac tgcaggtctg cacaggaaat gttcacctac atctgcaacc

661 acatcaagta tgccaccaac cggggcaacc ttcgctcggc catcacagtg ttcccgcagc

721 gctgccctgg ccgaggagac ttccgaatct ggaacagcca gctggtgcgc tacgcgggct

781 accggcagca ggacggctct gtgcgggggg acccagccaa cgtggagatc accgagctct

841 gcattcagca cggctggacc ccaggaaacg gtcgcttcga cgtgctgccc ctgctgctgc

901 aggccccaga tgagccccca gaactcttcc ttctgccccc cgagctggtc cttgaggtgc

961 ccctggagca ccccacgctg gagtggtttg cagccctggg cctgcgctgg tacgccctcc

1021 cggcagtgtc caacatgctg ctggaaattg ggggcctgga gttccccgca gcccccttca

1081 gtggctggta catgagcact gagatcggca cgaggaacct gtgtgaccct caccgctaca

1141 acatcctgga ggatgtggct gtctgcatgg acctggatac ccggaccacc tcgtccctgt

1201 ggaaagacaa ggcagcagtg gaaatcaacg tggccgtgct gcacagttac cagctagcca

1261 aagtcaccat cgtggaccac cacgccgcca cggcctcttt catgaagcac ctggagaatg

1321 agcagaaggc cagggggggc tgccctgcag actgggcctg gatcgtgccc cccatctcgg

1381 gcagcctcac tcctgttttc catcaggaga tggtcaacta tttcctgtcc ccggccttcc

1441 gctaccagcc agacccctgg aaggggagtg ccgccaaggg caccggcatc accaggaaga

1501 agacctttaa agaagtggcc aacgccgtga agatctccgc ctcgctcatg ggcacggtga

1561 tggcgaagcg agtgaaggcg acaatcctgt atggctccga gaccggccgg gcccagagct EPI-109 1190

1621 acgcacagca gctggggaga ctcttccgga aggcttttga tccccgggtc ctgtgtatgg

1681 atgagtatga cgtggtgtcc ctcgaacacg agacgctggt gctggtggta accagcacat

1741 ttgggaatgg ggatcccccg gagaatggag agagctttgc agctgccctg atggagatgt

1801 ccggccccta caacagctcc cctcggccgg aacagcacaa gagttataag atccgcttca

1861 acagcatctc ctgctcagac ccactggtgt cctcttggcg gcggaagagg aaggagtcca

1921 gtaacacaga cagtgcaggg gccctgggca ccctcaggtt ctgtgtgttc gggctcggct

1981 cccgggcata cccccacttc tgcgcctttg ctcgtgccgt ggacacacgg ctggaggaac

2041 tgggcgggga gcggctgctg cagctgggcc agggcgacga gctgtgcggc caggaggagg

2101 ccttccgagg ctgggcccag gctgccttcc aggccgcctg tgagaccttc tgtgtgggag

2161 aggatgccaa ggccgccgcc cgagacatct tcagccccaa acggagctgg aagcgccaga

2221 ggtaccggct gagcgcccag gccgagggcc tgcagttgct gccaggtctg atccacgtgc

2281 acaggcggaa gatgttccag gctacaatcc gctcagtgga aaacctgcaa agcagcaagt

2341 ccacgagggc caccatcctg gtgcgcctgg acaccggagg ccaggagggg ctgcagtacc

2401 agccggggga ccacataggt gtctgcccgc ccaaccggcc cggccttgtg gaggcgctgc

2461 tgagccgcgt ggaggacccg ccggcgccca ctgagcccgt ggcagtagag cagctggaga

2521 agggcagccc tggtggccct ccccccggct gggtgcggga cccccggctg cccccgtgca

2581 cgctgcgcca ggctctcacc ttcttcctgg acatcacctc cccacccagc cctcagctct

2641 tgcggctgct cagcaccttg gcagaagagc ccagggaaca gcaggagctg gaggccctca

2701 gccaggatcc ccgacgctac gaggagtgga agtggttccg ctgccccacg ctgctggagg

2761 tgctggagca gttcccgtcg gtggcgctgc ctgccccact gctcctcacc cagctgcctc

2821 tgctccagcc ccggtactac tcagtcagct cggcacccag cacccaccca ggagagatcc

2881 acctcactgt agctgtgctg gcatacagga ctcaggatgg gctgggcccc ctgcactatg

2941 gagtctgctc cacgtggcta agccagctca agcccggaga ccctgtgccc tgcttcatcc

3001 ggggggctcc ctccttccgg ctgccacccg atcccagctt gccctgcatt ctggtgggtc

3061 caggcactgg cattgccccc ttccggggat tctggcagga gcggctgcat gacattgaga

3121 gcaaagggct gcagcccact cccatgactt tggtgttcgg ctgccgatgc tcccaacttg

3181 accatctcta ccgcgacgag gtgcagaacg cccagcagcg cggggtgttt ggccgagtcc

3241 tcaccgcctt ctcccgggaa cctgacaacc ccaagaccta cgtgcaggac atcctgagga

3301 cggagctggc tgcggaggtg caccgcgtgc tgtgcctcga gcggggccac atgtttgtct

3361 gcggcgatgt taccatggca accaacgtcc tgcagaccgt gcagcgcatc ctggcgacgg

3421 agggcgacat ggagctggac gaggccggcg acgtcatcgg cgtgctgcgg gatcagcaac

3481 gctaccacga agacattttc gggctcacgc tgcgcaccca ggaggtgaca agccgcatac

3541 gcacccagag cttttccttg caggagcgtc agttgcgggg cgcagtgccc tgggcgttcg

3601 accctcccgg ctcagacacc aacagcccct gagagccgcc tggctttccc ttccagttcc

3661 gggagagcgg ctgcccgact caggtccgcc

(2) INFORMATION FOR SEQ ID NO:35: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1872 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:35: 1 aggagtttcg acccgcgctg gcgagtcatg agcgccaagt ttcccactgg cgcgcaaact

61 tgagttactt ttgagcgtgg atactggcga agaggctgcg ggcggtatta gcgtttgcag

121 cgacttggct cgggcagctg acccaagtgt cctgtcttcc ttcctctgct tgtctctagg

181 ctctgaaact gcggagcggc caccggacgc cttctggagc aggtagcagc atgcagccgc

241 ctccaagtct gtgcggaccg gccctggttg cgctggttct tgcctgcggc ctgtcgcgga

301 tctggggaga ggagagaggc ttcccgcctg acagggccac tccgcttttg caaaccgcag

361 agataatgac gccacccact aagaccttat ggcccaaggg ttccaacgcc agtctggcgc

421 ggtcgttggc acctgcggag gtgcctaaag gagacaggac ggcaggatct ccgccacgca

481 ccatctcccc tcccccgtgc caaggaccca tcgagatcaa ggagactttc aaatacatca

541 acacggttgt gtcctgcctt gtgttcgtgc tggggatcat cgggaactcc acacttctga

601 gaattatcta caagaacaag tgcatgcgaa acggtcccaa tatcttgatc gccagcttgg

661 ctctgggaga cctgctgcac atcgtcattg acatccctat caatgtctac aagctgctgg

721 cagaggactg gccatttgga gctgagatgt gtaagctggt gcctttcata cagaaagcct

781 ccgtgggaat cactgtgctg agtctatgtg ctctgagtat tgacagatat cgagctgttg

841 cttcttggag tagaattaaa ggaattgggg ttccaaaatg gacagcagta gaaattgttt

901 tgatttgggt ggtctctgtg gttctggctg tccctgaagc cataggtttt gatataatta

961 cgatggacta caaaggaagt tatctgcgaa tctgcttgct tcatcccgtt cagaagacag

1021 ctttcatgca gttttacaag acagcaaaag attggtggct attcagtttc tatttctgct

1081 tgccattggc catcactgca tttttttata cactaatgac ctgtgaaatg ttgagaaaga

1141 aaagtggcat gcagattgct ttaaatgatc acctaaagca gagacgggaa gtggccaaaa

1201 ccgtcttttg cctggtcctt gtctttgccc tctgctggct tccccttcac ctcagcagga

1261 ttctgaagct cactctttat aatcagaatg atcccaatag atgtgaactt ttgagctttc

1321 tgttggtatt ggactatatt ggtatcaaca tggcttcact gaattcctgc attaacccaa

1381 ttgctctgta tttggtgagc aaaagattca aaaactgctt taagtcatgc ttatgctgct

1441 ggtgccagtc atttgaagaa aaacagtcct tggaggaaaa gcagtcgtgc ttaaagttca

1501 aagctaatga tcacggatat gacaacttcc gttccagtaa taaatacagc tcatcttgaa EPI-109 1191

1561 agaagaacta ttcactgtat ttcattttct ttatattgga ccgaagtcat taaaacaaaa

1621 tgaaacattt αccaaaacaa aacaaaaaac tatgtatttg cacagcacac tattaaaata

1681 ttaagtgtaa ttattttaac actcacagct acatatgaca ttttatgagc tgtttacggc

1741 atggaaagaa aatcagtggg aattaagaaa gcctcgtcgt gaaagcactt aattttttac

1801 agttagcact tcaacatagc tcttaacaac ttccaggata ttcacacaac acttaggctt

1861 aaaaatgagc tc

(2) INFORMATION FOR SEQ ID NO: 36: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4286 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 36: 1 gagacattcc ggtgggggac tctggccagc ccgagcaacg tggatcctga gagcactccc

61 aggtaggcat ttgccccggt gggacgcctt gccagagcag tgtgtggcag gcccccgtgg

121 aggatcaaca cagtggctga acactgggaa ggaactggta cttggagtct ggacatctga

181 aacttggctc tgaaactgcg cagcggccac cggacgcctt ctggagcagg tagcagcatg

241 cagccgcctc caagtctgtg cggacgcgcc ctggttgcgc tggttcttgc ctgcggcctg

301 tcgcggatct ggggagagga gagaggcttc ccgcctgaca gggccactcc gcttttgcaa

361 accgcagaga taatgacgcc acccactaag accttatggc ccaagggttc caacgccagt

421 ctggcgcggt cgttggcacc tgcggaggtg cctaaaggag acaggacggc aggatctccg

481 ccacgcacca tctcccctcc cccgtgccaa ggacccatcg agatcaagga gactttcaaa

541 tacatcaaca cggttgtgtc ctgccttgtg ttcgtgctgg ggatcatcgg gaactccaca

601 cttctgagaa ttatctacaa gaacaagtgc atgcgaaacg gtcccaatat cttgatcgcc

661 agcttggctc tgggagacct gctgcacatc gtcattgaca tccctatcaa tgtctacaag

721 ctgctggcag aggactggcc atttggagct gagatgtgta agctggtgcc tttcatacag

781 aaagcctccg tgggaatcac tgtgctgagt ctatgtgctc tgagtattga cagatatcga

841 gctgttgctt cttggagtag aattaaagga attggggttc caaaatggac agcagtagaa

901 attgttttga tttgggtggt ctctgtggtt ctggctgtcc ctgaagccat aggttttgat

961 ataattacga tggactacaa aggaagttat ctgcgaatct gcttgcttca tcccgttcag

1021 aagacagctt tcatgcagtt ttacaagaca gcaaaagatt ggtggctgtt cagtttctat

1081 ttctgcttgc cattggccat cactgcattt ttttatacac taatgacctg tgaaatgttg

1141 agaaagaaaa gtggcatgca gattgcttta aatgatcacc taaagcagag acgggaagtg

1201 gccaaaaccg tcttttgcct ggtccttgtc tttgccctct gctggcttcc ccttcacctc

1261 agcaggattc tgaagctcac tctttataat cagaatgatc ccaatagatg tgaacttttg

1321 agctttctgt tggtattgga ctatattggt atcaacatgg cttcactgaa ttcctgcatt

1381 aacccaattg ctctgtattt ggtgagcaaa agattcaaaa actgctttaa gtcatgctta

1441 tgctgctggt gccagtcatt tgaagaaaaa cagtccttgg aggaaaagca gtcgtgctta

1501 aagttcaaag ctaatgatca cggatatgac aacttccgtt ccagtaataa atacagctca

1561 tcttgaaaga agaactattc actgtatttc attttcttta tattggaccg aagtcattaa

1621 aacaaaatga aacatttgcc aaaacaaaac aaaaaactat gtatttgcac agcacactat

1681 taaaatatta agtgtaatta ttttaacact cacagctaca tatgacattt tatgagctgt

1741 ttacggcatg gaaagaaaat cagtgggaat taagaaagcc tcgtcgtgaa agcacttaat

1801 tttttacagt tagcacttca acatagctct taacaacttc caggatattc acacaacact

1861 taggcttaaa aatgagctca ctcagaattt ctattctttc taaaaagaga tttattttta

1921 aatcaatggg actctgatat aaaggaagaa taagtcactg taaaacagaa cttttaaatg

1981 aagcttaaat tactcaattt aaaattttaa aatcctttaa aacaactttt caattaatat

2041 tatcacacta ttatcagatt gtaattagat gcaaatgaga gagcagttta gttgttgcat

2101 ttttcggaca ctggaaacat ttaaatgatc aggagggagt aacagaaaga gcaaggctgt

2161 ttttgaaaat cattacactt tcactagaag cccaaacctc agcattctgc aatatgtaac

2221 caacatgtca caaacaagca gcatgtaaca gactggcaca tgtgccagct gaatttaaaa

2281 tataatactt ttaaaaagaa aattattaca tcctttacat tcagttaaga tcaaacctca

2341 caaagagaaa tagaatgttt gaaaggctat cccaaaagac ttttttgaat ctgtcattca

2401 cataccctgt gaagacaata ctatctacaa ttttttcagg attattaaaa tcttcttttt

2461 tcactatcgt agcttaaact ctgtttggtt ttgtcatctg taaatactta cctacataca

2521 ctgcatgtag atgattaaat gagggcaggc cctgtgctca tagctttacg atggagagat

2581 gccagtgacc tcataataaa gactgtgaac tgcctggtgc agtgtccaca tgacaaaggg

2641 gcaggtagca ccctctctca cccatgctgt ggttaaaatg gtttctagca tatgtataat

2701 gctatagtta aaatactatt tttcaaaatc atacagatta gtacatttaa cagctacctg

2761 taaagcttat tactaatttt tgtattattt ttgtaaatag ccaatagaaa agtttgcttg

2821 acatggtgct tttctttcat ctagaggcaa aactgctttt tgagaccgta agaacctctt

2881 agctttgtgc gttcctgcct aatttttata tcttctaagc aaagtgcctt aggatagctt

2941 gggatgagat gtgtgtgaaa gtatgtacaa gagaaaacgg aagagagagg aaatgaggtg

3001 gggttggagg aaacccatgg ggacagattc ccattcttag cctaacgttc gtcattgcct

3061 cgtcacatca atgcaaaagg tcctgatttt gttccagcaa aacacagtgc aatgttctca

3121 gagtgacttt agaaataaat tgggcccaag agctttaact cggtcttaaa atatgcccaa

3181 atttttactt tgtttttctt ttaataggct gggccacatg ttggaaataa gctagtaatg

3241 ttgttttctg tcaatattga atgtgatggt acagtaaacc aaaacccaac aatgtggcca EPI-109 1192

3301 gaaagaaaga gcaataataa ttaattcaca caccatatgg attctattta taaatcaccc 3361 acaaacttgt tctttaattt catcccaatc actttttcag aggcctgtta tcatagaagt 3421 cattttagac tctcaatttt aaattaattt tgaatcacta atattttcac agtttattaa 3481 tatatttaat ttctatttaa attttagatt atttttatta ccatgtactg aatttttaca 3541 tcctgatacc ctttccttct ccatgtcagt atcatgttct ctaattatct tgccaaattt 3601 tgaaactaca cacaaaaagc atacttgcat tatttataat aaaattgcat tcagtggctt 3661 tttaaaaaaa atgtttgatt caaaacttta acatactgat aagtaagaaa caattataat 3721 ttctttacat actcaaaacc aagatagaaa aaggtgctat cgttcaactt caaaacatgt 3781 ttcctagtat taaggacttt aatatagcaa cagacaaaat tattgttaac atggatgtta 3841 cagctcaaaa gatttataaa agattttaac ctattttctc ccttattatc cactgctaat 3901 gtggatgtat gttcaaacac cttttagtat tgatagctta catatggcca aaggaataca 3961 gtttatagca aaacatgggt atgctgtagc taactttata aaagtgtaat ataacaatgt 4021 aaaaaattat atatctggga ggattttttg gttgcctaaa gtggctatag ttactgattt 4081 tttattatgt aagcaaaacc aataaaaatt taagtttttt taacaactac cttatttttc 4141 actgtacaga cactaattca ttaaatacta attgattgtt taaaagaaat ataaatgtga 4201 caagtggaca ttatttatgt taaatataca attatcaagc aagtatgaag ttattcaatt 4261 aaaatgccac atttctggtc tctggg

(2) INFORMATION FOR SEQ ID NO: 37: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1719 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi)SEQUENCE DESCRIPTION: SEQ ID NO:37: 1 gggctgcagg tttcgacccg cgctggcgag tcatgagcgc caagtttccc actggcgcgc 61 aaacttgagt tacttttgag cgtggatact ggcgaagagg ctgcgggcgg tattagcgtt 121 tgcagcgact tggctcgggc agctgacccc aaagtgtctg tcttccttcc tctgcttgtc 181 tctaggctct gaaactgcgg cggccaccgg acgcttctgg agcaggtagc agcatgcagc 241 cgcctccaag tctgtgcgga cgcgccctgg ttgcgctggt tcttgcctgc ggcctgtcgc 301 ggatctgggg agaggagaga ggcttcccgc ccgacagggc cactccgctt ttgcaaaccg 361 cagagataat gacgccaccc actaagacct tatggcccaa gggttccaac gccagtctgg

421 cgcggtcgtt ggcacctgcg gaggtgccta aaggagacag gacggcagga tctccgccac 481 gcaccatctc ccctcccccg tgccaaggac ccatcgagat caaggagact ttcaaataca 541 tcaacacggt tgtgtcctgc cttgtgttcg tgctggggat catcgggaac tccacacttc 601 tgagaattat ctacaagaac aagtgcatgc gaaacggtcc caatatcttg atcgccagct 661 tggctctggg agacctgctg cacatcgtca ttgacatccc tatcaatgtc tacaagctgc 721 tggcagagga ctggccattt ggagctgaga tgtgtaagct ggtgcctttc atacagaaag 781 cctccgtggg aatcactgtg ctgagtctat gtgctctgag tattgacaga tatcgagctg

841 ttgcttcttg gagtagaatt aaaggaattg gggttccaaa atggacagca gtagaaattg

901 ttttgatttg ggtggtctct gtggttctgg ctgtccctga agccataggt tttgatataa

961 ttacgatgga ctacaaagga agttatctgc gaatctgctt gcttcatccc gttcagaaga

1021 cagctttcat gcagttttac aagacagcaa aagattggtg gctgttcagt ttctatttct 1081 gcttgccatt ggccatcact gcattttttt atacactaat gacctgtgaa atgttgagaa 1141 agaaaagtgg catgcagatt gctttaaatg atcacctaaa gcagagacgg gaagtggcca 1201 aaaccgtctt ttgcctggtc cttgtctttg ccctctgctg gcttcccctt cacctcagca 1261 ggattctgaa gctcactctt tataatcaga atgatcccaa tagatgtgaa cttttgagct 1321 ttctgttggt attggactat attggtatca acatggcttc actgaattcc tgcattaacc 1381 caattgctct gtatttggtg agcaaaagat tcaaaaactg ctttaagtca tgcttatgct 1441 gctggtgcca gtcatttgaa gaaaaacagt ccttggagga aaagcagtcg tgcttaaagt 1501 tcaaagctaa tgatcacgga tatgacaact tccgttccag taataaatac agctcatctt 1561 gaaagaagaa ctattcactg tatttcattt tctttatatt ggaccgaagt cattaaaaca

1621 aaatgaaaca tttgccaaaa caaaacaaaa aactatgtat ttgcacagca cactattaaa 1681 atattaagtg taattatttt aaaaaaaaaa aaaaaaaaa

(2) INFORMATION FOR SEQ ID NO: 38: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4156 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi)SEQUENCE DESCRIPTION: SEQ ID NO:38: cccactatgt tggccaggat ggtcttgatt tcttgacctc gtgttctgcc cgcctctacc

61 tcccaaagtg ccgggattac aggcgtgact gctgtgcccg gccccagcat cacttttata 121 gctttctgtg cctcttcctc tgggccttgg tgtatgaagc cacttgcctt tctctgttgg 181 gaagcgagca gaatcagatt gctactcatg atgcagtccg ggcagggcat actgtcacct 241 ttggctgtgg acacagttgt caggataggg gagaagccct ttaggtccgt cttcttgaca 301 cagccctcct acctggttac gctggtgctt tcgcttggtt tagacaacca agacacttga 361 gaattatgct gtcctcagaa tgtctgatga aaagaacaga ttcacttttt ggacacaatg EPI-109 1193

421 cccattagcc atctttgcca gtgtttctga tcaaaggttc cacatgcctg αtctaggaaa

481 gtaaactttt ttcagaataa atcctcaaat ggattactga gtagtctttg caccattccc

541 atcagcctaa tcagactgaa tggtcacgct cagtgcaaaa agctgttttg ctgttaggat

601 gtttcagtgt ttcttgtctt tcctggaaca gttcagttgt ttaaatttag taattcaatc

661 ctgaccagtg taaacccact taattattgc agcctaaaga attαagctac ttctactctt

721 cataaatgtg cccaagtaaa tatgtgtttt taatattcaa ccatggaaaa ttagtaattc

781 agatgataaa agctcatgtt ttggtgtctt tgtactcaga ttgtgaacag gcatatttca

841 ctgatttaga cttagtatac ttgatgagaa tgctcaggtt gaagagatag ttctgtcagc

901 aatccaacat ctatagcaat gtggaaaaag taatcaactc atatttcacg aatttgatgt

961 atgttgtgat ttagagggca tgagataaag tttatatttg aactgtgtgg ggtaggggga

1021 agaagaggtt gcttaagcaa atgggggggt gattgaggaa caagatgtct ctaagatgag

1081 aagttatttt cttgcatcat agaagcactc tythyacccg ngagtgattg tgttaactat

1141 aaatcattta tatctgtaca ttaaagcaga ttccctcaat taggcaaatt tggttagcca

1201 agcccaagtt attgtttgta cttgaaagta ataaagctgc atttccttaa aaatatattc

1261 tgtagttaag actttgtctt gctttccgga attcctgttt ttcttttcct ctagagacct

1321 cggcttgcaa ctggatcaaa cgctgtcgaa aggatgtaaa taggcagagc aactgttacc

1381 aagaaggcca ccacccccac ccaaaggcag tgaggagtgt ggggcttcgt ctgggctccc

1441 ccgagtctca acagtaatca acagtcaggt gttgattgca acttttcaag gtcagccacc

1501 gggagtagcc tattccctct aggaaccttg gagggcatac cttgctggga ctcaacttgg

1561 ctgagaaatg cacaagatgc caaaggagga aggattatag ggggcgtgtg tgtgaccccc

1621 aagaccgatc ttccgctatc accctaatct ccggttcccc gctacccggg cgggggtgag

1681 tatgtgacat gtgcctaact ctcagcagca acttcggcag caggtgtcga tcctaactaa

1741 gcaggagctg cggctgccgg gtgtgccctc accaagccat gcgagccccg ggcgcgcttc

1801 tcgcccgcat gtcgcggcta ctgcttctgc tactgctcaa ggtgtctgcc tcttctgccc

1861 tcggggtcgc ccctgcgtcc agaaacgaaa cttgtctggg ggagagctgt gcacctacag

1921 tgatccagcg ccgcggcagg gacgcctggg gaccgggaaa ttctgcaaga gacgttctgc

1981 gagcccgagc acccagggag gagcaggggg cagcgtttct tgcgggaccc tcctgggacc

2041 tgccggcggc cccggaccgt gacccggctg caggcagagg ggcggaggcg tcgacagccg

2101 gacccccggg acctccaacc aggccacctg tcccctggag gtggaaaggt gctcggggtc

2161 aggagccttc tgaaactttg gggagaggga accccacggc cctccagctc ttccttcaga

2221 tctcagagga ggaagagaag ggtcccagag gcgctgtcat ttccgggcgt agccaggagc

2281 agagtgtgaa gacagtcccc ggagccagcg atctttttta ctgtccaagg agagccggga

2341 aactccaggg ttcccaccac aagcccctgt ccaagacggc caatggactg gcggggcacg

2401 aagggtggac aattgcactc ccgggccggg cgctggccca gaatggatcc ttgggtgaag

2461 gaatccatga tcctgggggt ccccgccggg gaaacagcac gaaccggcgt gtgagactga

2521 agaacccctt ctacccgctg acccaggagt cctatggagc ctacgcggtc atgtgtctgt

2581 ccgtggtgat cttcgggacc ggcatcattg gcaacctggc ggtgatgtgc atcgtgtgcc

2641 acaactacta catgcggagc atctccaact ccctcttggc caacctggtc ttctgggact

2701 ttctcatcat cttcttctgc cttccgctgg tcatcttcca cgagctgacc aagaagtggc

2761 tggtggagga cttctcctgc aagatcgtgc cctatataga ggtcgcttct ctgggagtca

2821 ccactttcac cttatgtgct ctgtgcatag accgcttccg tgctgccacc aacgtacaga

2881 tgtactacga aatgatcgaa aactgttcct caacaactgc caaacttgct gttatatggg

2941 tgggagctct attgttagca cttccagaag ttgttctccg ccagctgagc aaggaggatt

3001 tggggtttag tggccgagct ccggcagaaa ggtgcattat taagatctct cctgatttac

3061 cagacaccat ctatgttcta gccctcacct acgacagtgc gagactgtgg tggtattttg

3121 gctgttactt ttgtttgccc acgcttttca ccatcacctg ctctctagtg actgcgagga

3181 aaatccgcaa agcagagaaa gcctgtaccc gagggaataa acggcagatt caactagaga

3241 gtcagatgaa ctgtacagta gtggcactga ccattttata tggattgggc attattcctg

3301 aaaatatctg caacattgtt actgcctaca tggctacagg ggtttcacag cagacaatgg

3361 acctccttaa tatcatcagc cagttccttt tgttctttaa gtcctgtgtc accccagtcc

3421 tccttttctg tctctgcaaa cccttcagtc gggccttcat ggagtgctgc tgctgttgct

3481 gtgaggaatg cattcagaag tcttcaacgg tgaccagtga tgacaatgac aacgagtaca

3541 ccacggaact cgaactctcg cctttcagtg ccatacgccg tgaaatgtcc acttttgctt

3601 ctgtcggaac tcattgctga aggacagtac ttggttgggt cagatttatt tgtttgattt

3661 tcatatcccg tgaaagtttt taattcatat ttttccttat agggaaaaat gcaaaaaaga

3721 aacaataaag aaagaaatat taactactgt agaactgatt ttacaaatta atatttgtgc

3781 tttgaaaaaa agtttctatt tagttattta agaagaatga gaaggccaat agttttagat

3841 tattttatct ggtatggtgc taatatttta tttgaaaaaa gttactgcaa cttaacttaa

3901 aattgctaac gttttttctt cttttaaaaa tacaattatt gtatattaat tatagcaatg

3961 tgattttgta ggttatttta tatttgagtt gtgattgaaa gtatgttgta tatggtattg

4021 tgagatgatt tgtacttgga agcattcaca aagtagcacc aaataaatta cactttattc

4081 tttaatgtca ttgtcaatct acttttaacc aatattcaat aaatcttcta attgccttaa

4141 aaaaaaaaaa aaaaaa

(2) INFORMATION FOR SEQ ID NO: 39: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1578 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single EPI-109 1194

(D) TOPOLOGY: linear (xι)SEQUENCE DESCRIPTION: SEQ ID NO:39: 1 gggctgcagg tttcgacccg cgctggcgag tcatgagcgc caagtttccc actggcgcgc

61 aaacttgagt tacttttgag cgtggatact ggcgaagagg ctgcgggcgg tattagcgtt

121 tgcagcgact tggctcgggc agctgacccc aaagtgtctg tcttccttcc tctgcttgtc

181 tctaggctct gaaactgcgg cggccaccgg acgcttctgg agcaggtagc agcatgcagc

241 cgcctccaag tctgtgcgga cgcgccctgg ttgcgctggt tcttgcctgc ggcctgtcgc

301 ggatctgggg agaggagaga ggcttcccgc ccgacagggc cactccgctt ttgcaaaccg

361 cagagataat gacgccaccc actaagacct tatggcccaa gggttccaac gccagtctgg

421 cgcggtcgtt ggcacctgcg gaggtgccta aaggagacag gacggcagga tctccgccac

481 gcaccatctc ccctcccccg tgccaaggac ccatcgagat caaggagact ttcaaataca

541 tcaacacggt tgtgtcctgc cttgtgttcg tgctggggat catcgggaac tccacacttc

601 tgagaattat ctacaagaac aagtgcatgc gaaacggtcc caatatcttg atcgccagct

661 tggctctggg agacctgctg cacatcgtca ttgacatccc tatcaatgtc tacaagctgc

721 tggcagagga ctggccattt ggagctgaga tgtgtaagct ggtgcctttc atacagaaag

781 cctccgtggg aatcactgtg ctgagtctat gtgctctgag tattgacaga tatcgagctg

841 ttgcttcttg gagtagaatt aaaggaattg gggttccaaa atggacagca gtagaaattg

901 ttttgatttg ggtggtctct gtggttctgg ctgtccctga agccataggt tttgatataa

961 ttacgatgga ctacaaagga agttatctgc gaatctgctt gcttcatccc gttcagaaga

1021 cagctttcat gcagttttac aagacagcaa aagattggtg gctgttcagt ttctatttct

1081 gcttgccatt ggccatcact gcattttttt atacactaat gacctgtgaa atgttgagaa

1141 agaaaagtgg catgcagatt gctttaaatg atcacctaaa gcagagacgg gaagtggcca

1201 aaaccgtctt ttgcctggtc cttgtctttg ccctctgctg gcttcccctt cacctcagca

1261 ggattctgaa gctcactctt tataatcaga atgatcccaa tagatgtgaa cttttgagct

1321 ttctgttggt attggactat attggtatca acatggcttc actgaattcc tgcattaacc

1381 caattgctct gtatttggtg agcaaaagat tcaaaaactg ctttaaggct gggccacatg

1441 ttggaaataa gctagtaatg ttgttttctg tcaatattga atgtgatggt acagtaaacc

1501 aaaacccaac aatgtggcca gaaagaaaga gcaataataa ttaattcaca caccatatgg

1561 attctattta taaatcac

(2) INFORMATION FOR SEQ ID NO: 40: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13611 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 40: 1 aggagtttcg acccgcgctg gcgagtcatg agcgccaagt ttcccactgg cgcgcaaact

61 tgagttactt ttgagcgtgg atactggcga agaggctgcg ggcggtatta gcgtttgcag

121 cgacttggct cgggcagctg acccaagtgt cctgtcttcc ttcctctgct tgtctctagg

181 ctctgaaact gcggagcggc caccggacgc cttctggagc aggtagcagc atgcagccgc

241 ctccaagtct gtgcggaccg gccctggttg cgctggttct tgcctgcggc ctgtcgcgga

301 tctggggaga ggagagaggc ttcccgcctg acagggccac tccgcttttg caaaccgcag

361 agataatgac gccacccact aagaccttat ggcccaaggg ttccaacgcc agtctggcgc

421 ggtcgttggc acctgcggag gtgcctaaag gagacaggac ggcaggatct ccgccacgca

481 ccatctcccc tcccccgtgc caaggaccca tcgagatcaa ggagactttc aaatacatca

541 acacggttgt gtcctgcctt gtgttcgtgc tggggatcat cgggaactcc acacttctga

601 gaattatcta caagaacaag tgcatgcgaa acggtcccaa tatcttgatc gccagcttgg

661 ctctgggaga cctgctgcac atcgtcattg acatccctat caatgtctac aagctgctgg

721 cagaggactg gccatttgga gctgagatgt gtaagctggt gcctttcata cagaaagcct

781 ccgtgggaat cactgtgctg agtctatgtg ctctgagtat tgacagatat cgagctgttg

841 cttcttggag tagaattaaa ggaattgggg ttccaaaatg gacagcagta gaaattgttt

901 tgatttgggt ggtctctgtg gttctggctg tccctgaagc cataggtttt gatataatta

961 cgatggacta caaaggaagt tatctgcgaa tctgcttgct tcatcccgtt cagaagacag

1021 ctttcatgca gttttacaag acagcaaaag attggtggct attcagtttc tatttctgct

1081 tgccattggc catcactgca tttttttata cactaatgac ctgtgaaatg ttgagaaaga

1141 aaagtggcat gcagattgct ttaaatgatc acctaaagca gagacgggaa gtggccaaaa

1201 ccgtcttttg cctggtcctt gtctttgccc tctgctggct tccccttcac ctcagcagga

1261 ttctgaagct cactctttat aatcagaatg atcccaatag atgtgaactt ttgagctttc

1321 tgttggtatt ggactatatt ggtatcaaca tggcttcact gaattcctgc attaacccaa

1381 ttgctctgta tttggtgagc aaaagattca aaaactgctt taagtcatgc ttatgctgct

1441 ggtgccagtc atttgaagaa aaacagtcct tggaggaaaa gcagtcgtgc ttaaagttca

1501 aagctaatga tcacggatat gacaacttcc gttccagtaa taaatacagc tcatcttgaa

1561 agaagaacta ttcactgtat ttcattttct ttatattgga ccgaagtcat taaaacaaaa

1621 tgaaacattt gccaaaacaa aacaaaaaac tatgtatttg cacagcacac tattaaaata

1681 ttaagtgtaa ttattttaac actcacagct acatatgaca ttttatgagc tgtttacggc

1741 atggaaagaa aatcagtggg aattaagaaa gcctcgtcgt gaaagcactt aattttttac

1801 agttagcact tcaacatagc tcttaacaac ttccaggata ttcacacaac acttaggctt

1861 aaaaatgagc tc EPI-109 1195 gagacattcc ggtgggggac tctggccagc ccgagcaacg tggatcctga gagcactccc

61 aggtaggcat ttgccccggt gggacgcctt gccagagcag tgtgtggcag gcccccgtgg

121 aggatcaaca cagtggctga acactgggaa ggaactggta cttggagtct ggacatctga

181 aacttggctc tgaaactgcg cagcggccac cggacgcctt ctggagcagg tagcagcatg

241 cagccgcctc caagtctgtg cggacgcgcc ctggttgcgc tggttcttgc ctgcggcctg

301 tcgcggatct ggggagagga gagaggcttc ccgcctgaca gggccactcc gcttttgcaa

361 accgcagaga taatgacgcc acccactaag accttatggc ccaagggttc caacgccagt

421 ctggcgcggt cgttggcacc tgcggaggtg cctaaaggag acaggacggc aggatctccg

481 ccacgcacca tctcccctcc cccgtgccaa ggacccatcg agatcaagga gactttcaaa

541 tacatcaaca cggttgtgtc ctgccttgtg ttcgtgctgg ggatcatcgg gaactccaca

601 cttctgagaa ttatctacaa gaacaagtgc atgcgaaacg gtcccaatat cttgatcgcc

661 agcttggctc tgggagacct gctgcacatc gtcattgaca tccctatcaa tgtctacaag

721 ctgctggcag aggactggcc atttggagct gagatgtgta agctggtgcc tttcatacag

781 aaagcctccg tgggaatcac tgtgctgagt ctatgtgctc tgagtattga cagatatcga

841 gctgttgctt cttggagtag aattaaagga attggggttc caaaatggac agcagtagaa

901 attgttttga tttgggtggt ctctgtggtt ctggctgtcc ctgaagccat aggttttgat

961 ataattacga tggactacaa aggaagttat ctgcgaatct gcttgcttca tcccgttcag

1021 aagacagctt tcatgcagtt ttacaagaca gcaaaagatt ggtggctgtt cagtttctat

1081 ttctgcttgc cattggccat cactgcattt ttttatacac taatgacctg tgaaatgttg

1141 agaaagaaaa gtggcatgca gattgcttta aatgatcacc taaagcagag acgggaagtg

1201 gccaaaaccg tcttttgcct ggtccttgtc tttgccctct gctggcttcc ccttcacctc

1261 agcaggattc tgaagctcac tctttataat cagaatgatc ccaatagatg tgaacttttg

1321 agctttctgt tggtattgga ctatattggt atcaacatgg cttcactgaa ttcctgcatt

1381 aacccaattg ctctgtattt ggtgagcaaa agattcaaaa actgctttaa gtcatgctta

1441 tgctgctggt gccagtcatt tgaagaaaaa cagtccttgg aggaaaagca gtcgtgctta

1501 aagttcaaag ctaatgatca cggatatgac aacttccgtt ccagtaataa atacagctca

1561 tcttgaaaga agaactattc actgtatttc attttcttta tattggaccg aagtcattaa

1621 aacaaaatga aacatttgcc aaaacaaaac aaaaaactat gtatttgcac agcacactat

1681 taaaatatta agtgtaatta ttttaacact cacagctaca tatgacattt tatgagctgt

1741 ttacggcatg gaaagaaaat cagtgggaat taagaaagcc tcgtcgtgaa agcacttaat

1801 tttttacagt tagcacttca acatagctct taacaacttc caggatattc acacaacact

1861 taggcttaaa aatgagctca ctcagaattt ctattctttc taaaaagaga tttattttta

1921 aatcaatggg actctgatat aaaggaagaa taagtcactg taaaacagaa cttttaaatg

1981 aagcttaaat tactcaattt aaaattttaa aatcctttaa aacaactttt caattaatat

2041 tatcacacta ttatcagatt gtaattagat gcaaatgaga gagcagttta gttgttgcat

2101 ttttcggaca ctggaaacat ttaaatgatc aggagggagt aacagaaaga gcaaggctgt

2161 ttttgaaaat cattacactt tcactagaag cccaaacctc agcattctgc aatatgtaac

2221 caacatgtca caaacaagca gcatgtaaca gactggcaca tgtgccagct gaatttaaaa

2281 tataatactt ttaaaaagaa aattattaca tcctttacat tcagttaaga tcaaacctca

2341 caaagagaaa tagaatgttt gaaaggctat cccaaaagac ttttttgaat ctgtcattca

2401 cataccctgt gaagacaata ctatctacaa ttttttcagg attattaaaa tcttcttttt

2461 tcactatcgt agcttaaact ctgtttggtt ttgtcatctg taaatactta cctacataca

2521 ctgcatgtag atgattaaat gagggcaggc cctgtgctca tagctttacg atggagagat

2581 gccagtgacc tcataataaa gactgtgaac tgcctggtgc agtgtccaca tgacaaaggg

2641 gcaggtagca ccctctctca cccatgctgt ggttaaaatg gtttctagca tatgtataat

2701 gctatagtta aaatactatt tttcaaaatc atacagatta gtacatttaa cagctacctg

2761 taaagcttat tactaatttt tgtattattt ttgtaaatag ccaatagaaa agtttgcttg

2821 acatggtgct tttctttcat ctagaggcaa aactgctttt tgagaccgta agaacctctt

2881 agctttgtgc gttcctgcct aatttttata tcttctaagc aaagtgcctt aggatagctt

2941 gggatgagat gtgtgtgaaa gtatgtacaa gagaaaacgg aagagagagg aaatgaggtg

3001 gggttggagg aaacccatgg ggacagattc ccattcttag cctaacgttc gtcattgcct

3061 cgtcacatca atgcaaaagg tcctgatttt gttccagcaa aacacagtgc aatgttctca

3121 gagtgacttt cgaaataaat tgggcccaag agctttaact cggtcttaaa atatgcccaa

3181 atttttactt tgtttttctt ttaataggct gggccacatg ttggaaataa gctagtaatg

3241 ttgttttctg tcaatattga atgtgatggt acagtaaacc aaaacccaac aatgtggcca

3301 gaaagaaaga gcaataataa ttaattcaca caccatatgg attctattta taaatcaccc

3361 acaaacttgt tctttaattt catcccaatc actttttcag aggcctgtta tcatagaagt

3421 cattttagac tctcaatttt aaattaattt tgaatcacta atattttcac agtttattaa

3481 tatatttaat ttctatttaa attttagatt atttttatta ccatgtactg aatttttaca

3541 tcctgatacc ctttccttct ccatgtcagt atcatgttct ctaattatct tgccaaattt

3601 tgaaactaca cacaaaaagc atacttgcat tatttataat aaaattgcat tcagtggctt

3661 tttaaaaaaa atgtttgatt caaaacttta acatactgat aagtaagaaa caattataat

3721 ttctttacat actcaaaacc aagatagaaa aaggtgctat cgttcaactt caaaacatgt

3781 ttcctagtat taaggacttt aatatagcaa cagacaaaat tattgttaac atggatgtta

3841 cagctcaaaa gatttataaa agattttaac ctattttctc ccttattatc cactgctaat

3901 gtggatgtat gttcaaacac cttttagtat tgatagctta catatggcca aaggaataca

3961 gtttatagca aaacatgggt atgctgtagc taactttata aaagtgtaat ataacaatgt

4021 aaaaaattat atatctggga ggattttttg gttgcctaaa gtggctatag ttactgattt EPI-109 1196

4081 tttattatgt aagcaaaacc aataaaaatt taagtttttt taacaactac cttatttttc 4141 actgtacaga cactaattca ttaaatacta attgattgtt taaaagaaat ataaatgtga 4201 caagtggaca ttatttatgt taaatataca attatcaagc aagtatgaag ttattcaatt 4261 aaaatgccac atttctggtc tctggg 1 gggctgcagg tttcgacccg cgctggcgag tcatgagcgc caagtttccc actggcgcgc

61 aaacttgagt tacttttgag cgtggatact ggcgaagagg ctgcgggcgg tattagcgtt

121 tgcagcgact tggctcgggc agctgacccc aaagtgtctg tcttccttcc tctgcttgtc

181 tctaggctct gaaactgcgg cggccaccgg acgcttctgg agcaggtagc agcatgcagc

241 cgcctccaag tctgtgcgga cgcgccctgg ttgcgctggt tcttgcctgc ggcctgtcgc

301 ggatctgggg agaggagaga ggcttcccgc ccgacagggc cactccgctt ttgcaaaccg

361 cagagataat gacgccaccc actaagacct tatggcccaa gggttccaac gccagtctgg

421 cgcggtcgtt ggcacctgcg gaggtgccta aaggagacag gacggcagga tctccgccac

481 gcaccatctc ccctcccccg tgccaaggac ccatcgagat caaggagact ttcaaataca

541 tcaacacggt tgtgtcctgc cttgtgttcg tgctggggat catcgggaac tccacacttc

601 tgagaattat ctacaagaac aagtgcatgc gaaacggtcc caatatcttg atcgccagct

661 tggctctggg agacctgctg cacatcgtca ttgacatccc tatcaatgtc tacaagctgc

721 tggcagagga ctggccattt ggagctgaga tgtgtaagct ggtgcctttc atacagaaag

781 cctccgtggg aatcactgtg ctgagtctat gtgctctgag tattgacaga tatcgagctg

841 ttgcttcttg gagtagaatt aaaggaattg gggttccaaa atggacagca gtagaaattg

901 ttttgatttg ggtggtctct gtggttctgg ctgtccctga agccataggt tttgatataa

961 ttacgatgga ctacaaagga agttatctgc gaatctgctt gcttcatccc gttcagaaga

1021 cagctttcat gcagttttac aagacagcaa aagattggtg gctgttcagt ttctatttct

1081 gcttgccatt ggccatcact gcattttttt atacactaat gacctgtgaa atgttgagaa

1141 agaaaagtgg catgcagatt gctttaaatg atcacctaaa gcagagacgg gaagtggcca

1201 aaaccgtctt ttgcctggtc cttgtctttg ccctctgctg gcttcccctt cacctcagca

1261 ggattctgaa gctcactctt tataatcaga atgatcccaa tagatgtgaa cttttgagct

1321 ttctgttggt attggactat attggtatca acatggcttc actgaattcc tgcattaacc

1381 caattgctct gtatttggtg agcaaaagat tcaaaaactg ctttaagtca tgcttatgct

1441 gctggtgcca gtcatttgaa gaaaaacagt ccttggagga aaagcagtcg tgcttaaagt

1501 tcaaagctaa tgatcacgga tatgacaact tccgttccag taataaatac agctcatctt

1561 gaaagaagaa ctattcactg tatttcattt tctttatatt ggaccgaagt cattaaaaca

1621 aaatgaaaca tttgccaaaa caaaacaaaa aactatgtat ttgcacagca cactattaaa

1681 atattaagtg taattatttt aaaaaaaaaa aaaaaaaaa

1 cccactatgt tggccaggat ggtcttgatt tcttgacctc gtgttctgcc cgcctctacc

61 tcccaaagtg ccgggattac aggcgtgact gctgtgcccg gccccagcat cacttttata

121 gctttctgtg cctcttcctc tgggccttgg tgtatgaagc cacttgcctt tctctgttgg

181 gaagcgagca gaatcagatt gctactcatg atgcagtccg ggcagggcat actgtcacct

241 ttggctgtgg acacagttgt caggataggg gagaagccct ttaggtccgt cttcttgaca

301 cagccctcct acctggttac gctggtgctt tcgcttggtt tagacaacca agacacttga

361 gaattatgct gtcctcagaa tgtctgatga aaagaacaga ttcacttttt ggacacaatg

421 cccattagcc atctttggca gtgtttctga tcaaaggttc cccatgcctg ctctaggaaa

481 gtaaactttt ttcagaataa atcctcaaat ggattactga gtagtctttg caccattccc

541 atcagcctaa tcagactgaa tggtcacgct cagtgcaaaa agctgttttg ctgttaggat

601 gtttcagtgt ttcttgtctt tcctggaaca gttcagttgt ttaaatttag taattcaatc

661 ctgaccagtg taaacccact taattattgc agcctaaaga attcagctac ttctactctt

721 cataaatgtg cccaagtaaa tatgtgtttt taatattcaa ccctggaaaa ttagtaattc

781 agatgataaa agctcatgtt ttggtgtctt tgtactcaga ttgtgaacag gcatatttca

841 ctgatttaga cttagtatac ttgatgagaa tgctcaggtt gaagagatag ttctgtcagc

901 aatccaacat ctatagcaat gtggaaaaag taatcaactc atatttcacg aatttgatgt

961 atgttgtgat ttagagggca tgagataaag tttatatttg aactgtgtgg ggtaggggga

1021 agaagaggtt gcttaagcaa atgggggggt gattgaggaa caagatgtct ctaagatgag

1081 aagttatttt cttgcatcat agaagcactc tythyacccg ngagtgattg tgttaactat

1141 aaatcattta tatctgtaca ttaaagcaga ttccctcaat taggcaaatt tggttagcca

1201 agcccaagtt attgtttgta cttgaaagta ataaagctgc atttccttaa aaatatattc

1261 tgtagttaag actttgtctt gctttccgga attcctgttt ttcttttcct ctagagacct

1321 cggcttgcaa ctggatcaaa cgctgtcgaa aggatgtaaa taggcagagc aactgttacc

1381 aagaaggcca ccacccccac ccaaaggcag tgaggagtgt ggggcttcgt ctgggctccc

1441 ccgagtctca acagtaatca acagtcaggt gttgattgca acttttcaag gtcagccacc

1501 gggagtagcc tattccctct aggaaccttg gagggcatac cttgctggga ctcaacttgg

1561 ctgagaaatg cacaagatgc caaaggagga aggattatag ggggcgtgtg tgtgaccccc

1621 aagaccgatc ttccgctatc accctaatct ccggttcccc gctacccggg cgggggtgag

1681 tatgtgacat gtgcctaact ctcagcagca acttcggcag caggtgtcga tcctaactaa

1741 gcaggagctg cggctgccgg gtgtgccctc accaagccat gcgagccccg ggcgcgcttc

1801 tcgcccgcat gtcgcggcta ctgcttctgc tactgctcaa ggtgtctgcc tcttctgccc

1861 tcggggtcgc ccctgcgtcc agaaacgaaa cttgtctggg ggagagctgt gcacctacag

1921 tgatccagcg ccgcggcagg gacgcctggg gaccgggaaa ttctgcaaga gacgttctgc

1981 gagcccgagc acccagggag gagcaggggg cagcgtttct tgcgggaccc tcctgggacc

2041 tgccggcggc cccggaccgt gacccggctg caggcagagg ggcggaggcg tcgacagccg EPI-109 1197

2101 gacccccggg acctccaacc aggccacctg tcccctggag gtggaaaggt gctcggggtc

2161 aggagccttc tgaaactttg gggagaggga accccacggc cctccagctc ttccttcaga

2221 tctcagagga ggaagagaag ggtcccagag gcgctgtcat ttccgggcgt agccaggagc

2281 agagtgtgaa gacagtcccc ggagccagcg atctttttta ctgtccaagg agagccggga

2341 aactccaggg ttcccaccac aagcccctgt ccaagacggc caatggactg gcggggcacg

2401 aagggtggac aattgcactc ccgggccggg cgctggccca gaatggatcc ttgggtgaag

2461 gaatccatga tcctgggggt ccccgccggg gaaacagcac gaaccggcgt gtgagactga

2521 agaacccctt ctacccgctg acccaggagt cctatggagc ctacgcggtc atgtgtctgt

2581 ccgtggtgat cttcgggacc ggcatcattg gcaacctggc ggtgatgtgc atcgtgtgcc

2641 acaactacta catgcggagc atctccaact ccctcttggc caacctggtc ttctgggact

2701 ttctcatcat cttcttctgc cttccgctgg tcatcttcca cgagctgacc aagaagtggc

2761 tggtggagga cttctcctgc aagatcgtgc cctatataga ggtcgcttct ctgggagtca

2821 ccactttcac cttatgtgct ctgtgcatag accgcttccg tgctgccacc aacgtacaga

2881 tgtactacga aatgatcgaa aactgttcct caacaactgc caaacttgct gttatatggg

2941 tgggagctct attgttagca cttccagaag ttgttctccg ccagctgagc aaggaggatt

3001 tggggtttag tggccgagct ccggcagaaa ggtgcattat taagatctct cctgatttac

3061 cagacaccat ctatgttcta gccctcacct acgacagtgc gagactgtgg tggtattttg

3121 gctgttactt ttgtttgccc acgcttttca ccatcacctg ctctctagtg actgcgagga

3181 aaatccgcaa agcagagaaa gcctgtaccc gagggaataa acggcagatt caactagaga

3241 gtcagatgaa ctgtacagta gtggcactga ccattttata tggattgggc attattcctg

3301 aaaatatctg caacattgtt actgcctaca tggctacagg ggtttcacag cagacaatgg

3361 acctccttaa tatcatcagc cagttccttt tgttctttaa gtcctgtgtc accccagtcc

3421 tccttttctg tctctgcaaa cccttcagtc gggccttcat ggagtgctgc tgctgttgct

3481 gtgaggaatg cattcagaag tcttcaacgg tgaccagtga tgacaatgac aacgagtaca

3541 ccacggaact cgaactctcg cctttcagtg ccatacgccg tgaaatgtcc acttttgctt

3601 ctgtcggaac tcattgctga aggacagtac ttggttgggt cagatttatt tgtttgattt

3661 tcatatcccg tgaaagtttt taattcatat ttttccttat agggaaaaat gcaaaaaaga

3721 aacaataaag aaagaaatat taactactgt agaactgatt ttacaaatta atatttgtgc

3781 tttgaaaaaa agtttctatt tagttattta agaagaatga gaaggccaat agttttagat

3841 tattttatct ggtatggtgc taatatttta tttgaaaaaa gttactgcaa cttaacttaa

3901 aattgctaac gttttttctt cttttaaaaa tacaattatt gtatattaat tatagcaatg

3961 tgattttgta ggttatttta tatttgagtt gtgattgaaa gtatgttgta tatggtattg

4021 tgagatgatt tgtacttgga agcattcaca aagtagcacc aaataaatta cactttattc

4081 tttaatgtca ttgtcaatct acttttaacc aatattcaat aaatcttcta attgccttaa

4141 aaaaaaaaaa aaaaaa 1 gggctgcagg tttcgacccg cgctggcgag tcatgagcgc caagtttccc actggcgcgc

61 aaacttgagt tacttttgag cgtggatact ggcgaagagg ctgcgggcgg tattagcgtt

121 tgcagcgact tggctcgggc agctgacccc aaagtgtctg tcttccttcc tctgcttgtc

181 tctaggctct gaaactgcgg cggccaccgg acgcttctgg agcaggtagc agcatgcagc

241 cgcctccaag tctgtgcgga cgcgccctgg ttgcgctggt tcttgcctgc ggcctgtcgc

301 ggatctgggg agaggagaga ggcttcccgc ccgacagggc cactccgctt ttgcaaaccg

361 cagagataat gacgccaccc actaagacct tatggcccaa gggttccaac gccagtctgg

421 cgcggtcgtt ggcacctgcg gaggtgccta aaggagacag gacggcagga tctccgccac

481 gcaccatctc ccctcccccg tgccaaggac ccatcgagat caaggagact ttcaaataca

541 tcaacacggt tgtgtcctgc cttgtgttcg tgctggggat catcgggaac tccacacttc

601 tgagaattat ctacaagaac aagtgcatgc gaaacggtcc caatatcttg atcgccagct

661 tggctctggg agacctgctg cacatcgtca ttgacatccc tatcaatgtc tacaagctgc

721 tggcagagga ctggccattt ggagctgaga tgtgtaagct ggtgcctttc atacagaaag

781 cctccgtggg aatcactgtg ctgagtctat gtgctctgag tattgacaga tatcgagctg

841 ttgcttcttg gagtagaatt aaaggaattg gggttccaaa atggacagca gtagaaattg

901 ttttgatttg ggtggtctct gtggttctgg ctgtccctga agccataggt tttgatataa

961 ttacgatgga ctacaaagga agttatctgc gaatctgctt gcttcatccc gttcagaaga

1021 cagctttcat gcagttttac aagacagcaa aagattggtg gctgttcagt ttctatttct

1081 gcttgccatt ggccatcact gcattttttt atacactaat gacctgtgaa atgttgagaa

1141 agaaaagtgg catgcagatt gctttaaatg atcacctaaa gcagagacgg gaagtggcca

1201 aaaccgtctt ttgcctggtc cttgtctttg ccctctgctg gcttcccctt cacctcagca

1261 ggattctgaa gctcactctt tataatcaga atgatcccaa tagatgtgaa cttttgagct

1321 ttctgttggt attggactat attggtatca acatggcttc actgaattcc tgcattaacc

1381 caattgctct gtatttggtg agcaaaagat tcaaaaactg ctttaaggct gggccacatg

1441 ttggaaataa gctagtaatg ttgttttctg tcaatattga atgtgatggt acagtaaacc

1501 aaaacccaac aatgtggcca gaaagaaaga gcaataataa ttaattcaca caccatatgg

1561 attctattta taaatcac

(2) INFORMATION FOR SEQ ID NO: 41: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12461 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear EPI-109 1198

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 41: 1 gatatcctat taatacagag atacagaaag aaatacataa aaaatagttt tatcaaatac

61 tttccagcat tcaagtgtag cctcaaaagc aagaataggc caggagtggt ggctcacgct

121 gtaatccaca gcactgtggg aggccaaggt aagaggattg cttgaggcca ggatttcaag

181 accagcctag gcaacatagt gagatcccta tctctacgaa aaaattttaa aacttagctg

241 ggcatggtgc ttgagcctgt tgtcccagct actcaggagg tgaagtagga gtgtcacttg

301 agcccaggag gttgaggctg cagtgagcta taactgcacc actgcactcc agccttggag

361 acagagtgag accctgtccc caaaaaaatt aaaattgaga aaaaaaaaaa ggcaagaaca

421 gccacagcaa actttctatt ggggaaaaaa aaaaatcctc ctctttacat ctctcccttc

481 cttcccttcc ctttctgaga gtgactgtgg ccaaaaggag cattttcccc ctgcagtcct

541 ctgaggggtg gggtggggct atgaagctat ccttcatatt cactcctttg tccagctctt

601 ttcacctcta gttcttctcc ccgcatctct gtctagcagt gccttaagtg gaggaggggt

661 gggggcatca agcttgtaaa actggtttgt tggggttctc cttctcccct catttcttga

721 ttcttgggaa aatgtcttgc tgggaggctg cctggcgagt gccctagctg ccttctgtgg

781 gcttgaatgg ggcttccctc tgcccctaca ggaggaaaag ggagctgctg ccagagggag

841 aaatggagag atggacagag aaggcaggtg ccacccctcg cccctgacac acaaagaaaa

901 agacacggaa attctctctc tctcttctct tctcctatct ctctctctct ccctctctct

961 ctctctctct ctctctctca cacacacaca cacacacaca cacacacaca caggcgcgcg

1021 ccgcgcgcgc aggcacacgt cttgcaaatt caggattcaa agagacaggg gcaccattat

1081 atttggcacg gtggggcctt ccaggtctga aatcctgcat tcttccttac tatttacttt

1141 ccccgagctc gagaagggcc aggtgtgggc ggatggctgg ccacgttttg tgtttccaat

1201 tcatattcac gggatgacac agacggggcg tggtgagtgc tgttggaggc gcttgggcag

1261 tttcattttg ccccacttct ccacctgaag gctgggcgtt gctggaacct gcaggggcag

1321 cctcagcaag gtggggtggc gtggagtggg gtgggagaag ggactccagc tgaagtagaa

1381 cccaggctgg acctgagaat attggggagg gcatgggcgg tggtttccgg gtaggggcct

1441 tgaggacatg ttggtcctga ctgttgtcag tgtttggtca aagttgccaa aaggttaaaa

1501 aaaaaaaagt agggggagtc cctgccaaga catatttccc aggccacctt tcttccgcgg

1561 gagtgttggg ggggaggcgc tgcttggaac ctgtgaatgt gacatcagct ctcctctcct

1621 ctcccaaggt cggctttgga gagggaggtc agggcaccct tgcctggcac aggcacgctg

1681 gcttccggct cagtgccgcc tgctctccgg gagctgtgcg ctccctgggc cccggggcta

1741 ggctgaggta agcgcacagc ggaggccagg cgcgccggca gaggcctggg ggatagggtg

1801 gaggcatctc tgggtgtggg tgtgggtgtg ggtgtgggag ggagagttct tgcctctctc

1861 tctcccatct ccaactcttg cttcagtggc tcttttagag gatgcatgtc attatggacc

1921 tgtcgctgcc actgtccctg ttcccccagc tgtgacttcg agggaggtct ggggatctga

1981 gtctgtccaa acccacggct ttgctgttgg gataaaaact gtccttttga ttttagaagg

2041 aggagggaaa aaaggtttcc cagcatgtgt gttgtgccag tcttggaaat tcatccgtgc

2101 ttgaattcca ccctccatcc ccagaaaaac tggagtaaaa caaaaagagg agatggacaa

2161 agtgtgtatt tgatggcatc ccctgggaag agactctaaa tttatcccat aggtcttact

2221 gggccactgt gagcgctttg gtggagaaca aacaaaaatt ctgggtgctc agttgtctaa

2281 cctgaaaaat gggactagcg gaaaaagcca atgtgttcca tgcacctttt gctttcttta

2341 ttaaggcatg atgtcacctg tacagtaact gccctgtgtg tacttcaggg ggggatttca

2401 aggttagata gacaggaaat tgttttgaaa atgtaaacac attattaaat gtgaagtatt

2461 atctgattcc ttgttcgaat ggcatttcct tctcagcacc accttccttg catattcact

2521 taaccttgta caagaacacc tttttgccct aaatgaagac acccccccaa aaaaaagagt

2581 cccagaaaat atgtccctgc ttgtgcggga ataaatagaa tattctgagg tgcattcctc

2641 cttcctatgt taggcaacat tccttgaccc tcctcggccc ccaagccagg ttgcgttttt

2701 ttctgccatt tagaagggtt ttcctttttg tcctagtaaa acatcagccc ctgtagctct

2761 tcatctcccc ctggtgttct tctcccgcca tgtcttaaga ttggtggcac cgaccaatct

2821 taagatttaa gttctgtgtg aaaaacacct ttgcttttca atcagtttat cagcctcctc

2881 cgcaggggaa tgtggacaca caaaagaact tatcggggct tctcatcagt gatagggaaa

2941 agactggcat gtgcctaaac gagctctgat gttattttta agctcccttt cttgccaatc

3001 cctcacggat ctttctccga tagatgcaaa gaacttcagc aaaaaagacc cgcaggaagg

3061 ggcttgaaga gaaaagtacg ttgatctgcc aaaatagtct gacccccagt agtgggcagt

3121 gacgagggag agcattccct tgtttgactg agactagaat cggagagaca taaaaggaaa

3181 atgaagcgag caacaattaa aaaaaattcc ccgcacacaa caatacaatc tatttaaact

3241 gtggctcata cttttcatac caatggtatg actttttttc tggagtcccc tcttctgatt

3301 cttgaactcc ggggctggca gcttgcaaag gggaagcgga ctccagcact gcacgggcag

3361 gtttagcaaa ggtctctaat gggtattttc tttttcttag ccctgccccc gaattgtcag

3421 acggcgggcg tctgcttctg aagttagcag tgatttcctt tcgggcctgg cttatctccg

3481 gctgcacgtt gcctgttggt gactaataac acaataacat tgtctggggc tggaataaag

3541 tcggagctgt ttacccccac tctaataggg gttcaatata aaaagccggc agagagctgt

3601 ccaagtcaga cgcgcctctg catctgcgcc aggcgaacgg gtcctgcgcc tcctgcagtc

3661 ccagctctcc accgccgcgt gcgcctgcag acgctccgct cgctgccttc tctcctggca

3721 ggcgctgcct tttctccccg ttaaagggca cttgggctga aggatcgctt tgagatctga

3781 ggaacccgca gcgctttgag ggacctgaag ctgtttttct tcgttttcct ttgggttcag

3841 tttgaacggg aggtttttga tccctttttt tcagaatgga ttatttgctc atgattttct

3901 ctctgctgtt tgtggcttgc caaggagctc cagaaacagg taggcacgct cgttgacttg

3961 taagtctcgg aattacaagt tagtgtgttc ttatccacct tcatgctttt cttgcttcta EPI-109 1 199

4021 tttttccccg ttctttttat gactgcagct tagagagcaa gtgtctgaga attattgctg

4081 aaacgtactt taagtcttct agtgtaaaat gtaaaattcc tctactgaat acaattaggt

4141 gcaattgact ataacatgac attaaaataa cttatcgttt tattattatt attccattat

4201 gtgtttcctt ggcttttaaa aaatgagaag agtatggaca tatacaattt agtcaaatgt

4261 atgtttgtaa tatatgtgtt tatacaggta cacaggccat ataggaactt aaatcttatt

4321 taaacactat tttaatagtg tgttaacgtg taaaatattt aagcattcca gcttgaagcc

4381 aaggaattgt atccagtcgt tcaagcaatg tatgttcagt aaaatcacct gcagagcaaa

4441 agtctgttga ctaactaccg cctcccccgc ccccccacca ccccccgcag gcggtttctg

4501 ggtgaagcag atgttttctt taaaatttgt catcattgac tttaggtttc ttttggcagg

4561 tttttggcac ccaaaacagt gtgagctctc ttttcagctt tattcacctg tgctgggagg

4621 ggagctagga taattcttgg ctgccgaagg atttaggcag tgcgtgtgca tctgcccggg

4681 tcccccccgt ttttagggtc agtgcacttt ttttgtcttt tcgtgaccct gactaaagag

4741 aaaggatgtc aagggaatga aaatcctgga atgtgtctga tcatttgaaa tgtacaaaat

4801 tgggcagata agctgcatgg ctaaattgtt aggaggaaga ggcaaggcag tagtggagaa

4861 gggggaggca gtggatccca cacaagcctg atgcccaggg attcggaatt caaaatcccc

4921 ccagcctacc ttcagtcccc tgacctgctt ctcagcccca ccttaggtca ctggtttcta

4981 tggagttacc ctactgaatt gaatattgaa tagttaattt ctctctccaa tcattttccc

5041 cacctaattt tgaaagatat acatcatctg gggtaccctg tgccctacac agcatgtgaa

5101 gtggatgggt accccctaaa gagagggtca tcctgaatgg ggaagtggcc ccaaagctag

5161 gaataactgt gatttcttgt ctttagtcat gtgccaatgt taagtaagct tcagtggata

5221 gtgctgtcct accaagttcc ttgtagaagc cagccggatt ttcaacaggc agcattccac

5281 agcatttccc tgagcctgct tcaagagggg tgggggaagt cccttttcag gtgtttatct

5341 cctctgcatt tgtgtaatct ccctgaaggt ggataagcca agggcatgag ggggaggcaa

5401 aaggtgaact catgttaagg agggaaaaaa ataaagagcc cttttttctg tgtttcttgc

5461 tgatggcagg ctgtgtgctt catctgcttt tatctgctct gctagctctg actctactgt

5521 gatccagcat gtctctcggc gtttgaggag acatccccca ctgacctgct ctttctctcc

5581 ccagcagtct taggcgctga gctcagcgcg gtgggtgaga acggcgggga gaaacccact

5641 cccagtccac cctggcggct ccgccggtcc aagcgctgct cctgctcgtc cctgatggat

5701 aaagagtgtg tctacttctg ccacctggac atcatttggg tcaacactcc cgagtaagtc

5761 tctagagggc attgtaaccc tattcattca ttagcgctgg ctccactgga gcccagtttt

5821 agagtttctt ttctagggac tctgaaggta gtccttctaa caccatccaa gtgcctcagt

5881 ggggacagtt tccctctatt cctgaaaata acgacagctt cgttcttagc aaccaagggg

5941 agggtcttct gaggccccgt agctcaggct actcatgatg ggacaagcag gaggccactg

6001 cacgtttcaa atgaggaact ttcagtgaga gggcctcagg gggacactct cacagtggca

6061 tctgatgggg tttcgggaat aattgccgag gtcagatgtg ggttagtgca acctgtgctt

6121 ctcatgggag ggtggagact gagaggcaga agtgatgata tagagggtta gaatcactta

6181 attttagtta cagaaaaacc taggctcaaa gtgttgaagc catttgtgca ggagtgagtt

6241 tgtagcagag ctagaactgg agcccggatt tcctttgctg ctatattttc cctttagaaa

6301 tgcccatttc agaactgaaa tagaaatact gtccataggc ttctctttca cctacagaga

6361 agaaaagcag atttcctcct tctgccctgg acactagttc atcatctgtc ggaagcagtc

6421 ataaacaagc acacatttac tatgcataca atgtaccgtt atgacaaagg aggaccaaaa

6481 tccaaacaat atcaaaccac accaaaaacc acaaggagcc taataattac taaggtgata

6541 cttccaaagg gaggacttta tttcttagat gagaatgaaa atggacacat tggaaattat

6601 tggagagccc tctggctatg agtccttcca caaccatatg gtaccaccga ctggcaggag

6661 aaatgtgtga acatgtgcct cctctcccca accactgggg ccggtggggt gacggtggca

6721 cttttagcag tatcctccgt ggtttgagtt gaaaataagt tttaaaaatc ctgtgagtca

6781 tggttttgca ttgaaacctc ttcccactgt gtacccacaa atagttaact aaatagacca

6841 ttagaaaagg aagaaaatat aaagcagatg ccaagcagag atgtcctaat ttttgacaaa

6901 aaagcaatgt tgcttgtgtc aagaagaaac tgaactttgt gaagagttga aatggaattc

6961 cactgaatta gaaaaacttg ttttctcctg cctggataca tacagtcagg gccattgatg

7021 cacaggtgtt cctggctgtt gttacacttt accctctgaa atgatgctcc caagtgctat

7081 gtgatgagct ccttgtgtgc ccagtggaat aggtgtgtcc atgtgtcatt ttaaagacta

7141 ttaattacac taatatagtt tctttctctc tttggataat aggcacgttg ttccgtatgg

7201 acttggaagc cctaggtcca agagagcctt ggagaattta cttcccacaa aggcaacaga

7261 ccgtgagaat agatgccaat gtgctagcca aaaagacaag aagtgctgga atttttgcca

7321 agcaggaaaa gaactcaggt gagcagaaac acctttgctt ttcaatcagt ttaacagcct

7381 cctgaactcc ttcctatcat ggtactgcct tcctgtttta gagagactaa cagagacatt

7441 gaaagtcagg gtaaagctga atataacatt gctgaaatgt ttttccttgt gtattttaac

7501 agggctgaag acattatgga gaaagactgg aataatcata agaaaggaaa agactgttcc

7561 aagcttggga aaaagtgtat ttatcagcag ttagtgagag gaagaaaaat cagaagaagt

7621 tcagaggaac acctaagaca aaccaggtaa gagggaagga agaaaaatta ggtaagaggt

7681 tcacaagaac aactagcccc agtcagtgat gccagcagcc tgttcctcca gcccttctta

7741 cccgggcagg tgaaagactt agaaaacagt agcagaggag atctatgcat cctatagatt

7801 aaaaggagca aaagaatccc tcttaaatat ttccatgaag ctctggaatg caaaccgatg

7861 tcctctgtac ctttagcaca taccatttca tctacaggta gatttcccaa ccaaaatata

7921 tccagagatg cctttgtcat tgggttatat acagcctttg cctctctgag tcaatgtatt

7981 taccactttc cctgagaaat cgaaaatcat tttggggagc ggacatttag aaaaagaatc

8041 aaagtgtcat ggataatcaa attcttcaat aagttgcagt tattcagatg gccaaaggaa EPI-109 1200

8101 aaataaagtc attagatagg gttggtagaa tttagaacat gctgtttttc aggtttatgg

8161 tctttttttt tttttttttt tttttttaaa tagggaaatg tgtttggtgc agagccaatg

8221 tcattccaaa aagctctctc ttttcctggt cagtcatgtg ctgggacaga gaagggatct

8281 ggattaggca acatcataga gttgctctga gctgctcttt ggtgataacc cttccaaatc

8341 ctaaactttt tggaattcac aagctcaaag gaggaaacct actctctgat ctaccacatg

8401 ttctgcattt ttctatcatg gtctatggaa acttctctta gaaatccagt ggcaagaagt

8461 tctatgatta aagtgttctg agctcaggcc aggcagtcat gaactacttc tgagttgttt

8521 actactgatt tgtggggcag cctcagctat cggtttcttc acacctgctt atgagagtat

8581 ccatatttat ggtcgcaggc agtaatgctc cccacgagat cagtttctga actaacctgg

8641 aattttttat gggtttttat tatgccaact attaaatcaa cattacagtt cttccctctg

8701 tatttctcct gtaaaacatt aggcctgcaa aaaaaaaaaa tctttttaaa aataattgcc

8761 ataaagtatt tgctctgggc ctactgtatg cttcttttyt ttttctctct tttcaactaa

8821 gtcaccgtca atttattaag atggccataa ctattcaaaa cctatgctga gttcctcaag

8881 gcagggtcgc atagtgatga aggttgggat ggggctacgg aagaaaccag aacaactcta

8941 gtttatttaa aacctgtatt tactgcccac ttccccttag acttgaccat atgacccctt

9001 gctccccatt ctaagcatag gggcaggctt tatttttaca atggtaatag atgatatcac

9061 ttgaggtttt atcaaagagt tgcggcgggt ggtgaaagtt cacaaccaga ttcaggtttt

9121 gtttgtgcca gattctaatt ttacatgttt cttttgccaa agggtgattt ttttaaaata

9181 acatttgttt tctcttatct tgctttatta ggtcggagac catgagaaac agcgtcaaat

9241 catcttttca tgatcccaag ctgaaaggca agccctccag agagcgttat gtgacccaca

9301 accgagcaca ttggtgacag accttcgggg cctgtctgaa gccatagcct ccacggagag

9361 ccctgtggcc gactctgcac tctccaccct ggctgggatc agagcaggag catcctctgc

9421 tggttcctga ctggcaaagg accagcgtcc tcgttcaaaa cattccaaga aaggttaagg

9481 agttccccca accatcttca ctggcttcca tcagtggtaa ctgctttggt ctcttctttc

9541 atctggggat gacaatggac ctctcagcag aaacacacag tcacattcga attcgggtgg

9601 catcctccgg agagagagag aggaaggaga ttccacacag gggtggagtt tctgacgaag

9661 gtcctaaggg agtgtttgtg tctgactcag gcgcctggca catttcaggg agaaactcca

9721 aagtccacac aaagattttc taaggaatgc acaaattgaa aacacactca aaagacaaac

9781 atgcaagtaa agaaaaaaaa aagaaagact tttgtttaaa tttgtaaaat gcaaaactga

9841 atgaaactgt tactaccata aatcaggata tgtttcatga atatgagtct acctcaccta

9901 tattgcactc tggcagaagt atttcccaca tttaattatt gcctccccaa actcttccca

9961 cccctgctgc cccttcctcc atcccccata ctaaatccta gcctcgtaga agtctggtct

10021 aatgtgtcag cagtagatat aatattttca tggtaatcta ctagctctga tccataagaa

10081 aaaaaagatc attaaatcag gagattccct gtccttgatt tttggagaca caatggtata

10141 gggttgttta tgaaatatat tgaaaagtaa gtgtttgtta cgctttaaag cagtaaaatt

10201 attttccttt atataaccgg ctaatgaaag aggttggatt gaattttgat gtacttattt

10261 ttttatagat atttatattc aaacaattta ttccttatat ttaccatgtt aaatatctgt

10321 ttgggcaggc catattggtc tatgtatttt taaaatatgt atttctaaat gaaattgaga

10381 acatgctttg ttttgcctgt caaggtaatg actttagaaa ataaatattt ttttccttac

10441 tgtactgatt tggaatcatt actgaaattt gtaaggagtg ggccaacgtg attaagtacc

10501 ataaaggcaa ataaatggtt aaagacggtt tcatagaaaa gtgacaatta gaaggatatt

10561 acggtctaag ctaattatat aaagaatttt atctgtatct taaatgttga ttttatactg

10621 cattgaggta aaaacacaaa acaaaaaagc agctttaaca cctctgtctt ctcttgggta

10681 gcagcctcct gcttctcctt cacctgaaaa attctccagg gacttcatcc attaacttgg

10741 ctcaggctat tggcaggatt cacagtttaa gctgatggtg tggtgagaga tgctttatcc

10801 atattaatgg actgaaggaa gtaatggcaa gacaaccccc caaaacatac ctaattatac

10861 aaagttatat accaaagttg cttttagaaa atggcctgct cagagcaagt agaggtttcc

10921 aatggctttt tattttctca cattaaggat gttgtttctt aaggaacatt gagtaccatt

10981 gcttcttcgt gatagcctag gactgccgtg tgcccatgga ggtagagaca ccaggtactg

11041 attctaggtc ctctgccaca aagcaccact tcctctccac tttgccttgg ctggccttgt

11101 cagctcactg gagagcacag tattgcaatt gcagtattgc aaatggtcac tactaactga

11161 attctctaag agcttgatta gccctcgaga atcttccttg cccttctcta atagtgtctg

11221 aaggaattcc tggcatttaa caaatattag catgtagtga tcactgtcgt cctaacagtg

11281 acacatcaga aggatttcaa ataacagtct tcaggcatgc gtaatcaatg tcctgtgcag

11341 agtctccgtc ctcattgatc ctcatttttc tctttaaggc acagtccaat gtctttgggg

11401 aattgtttat aaagcttact ttatccataa actgtttctc agtgcgtgac tctgaagaaa

11461 attttgaagt tttgcccatg ttgacaaggt gcttggtctg aacttggcca gtatttaatc

11521 ttgagcaaac gattcaattt ccttctatcg tgagttttct catctatgaa acaagggagt

11581 tgaggggagt ttctttcata cctctgagaa agagtttgag attacataaa gaagttgaag

11641 tggcatgaaa aaaaataaag atctgagctt agaagacatg gatctaatac atttaagagg

11701 aagtcagaat cagagaagcc actgaacaaa acagtccaaa cggagcatag taagtcagat

11761 tgatgagttt tggttgggtt tttcatcagt caaacccttg agcccccctt tcccatgctt

11821 cctgcttcag tatccagtag gaaaaatgaa agggatgatg tagacactct agggcatgag

11881 gatttgcagt aaataagttg ggagactcac agaaaattaa tatttttcaa acatgaagac

11941 gaaacattca attatattac agtccacatc agcttgaagg gtaaactgat gggatgatct

12001 gtcacatttc ttgctctgtt tccagtaaaa gcatggtttc tggaaaccca cttaggacag

12061 ctttctctct ttacactgat agcccaggca agctttgatc tcagaactcc agaaaccaga

12121 gaactctagg tggaatgtgg taacttttgc cagggcagag ggaacaccta ctaataggta EPI-109 1201

12181 cttcatttgc accaccagag attggcatct tttttgatgg atcαactggc tttgatactg

12241 cctgtactcc cccaaaacac agcttgggta ttggactaat ctagagctcc ctcaggagaa

12301 ctcttgctga cattaagaaa gagcaacatt ttgtctttcc aggtgaaaat ccaaggccaa

12361 aaagggagtg actcacctaa gatcacagaa ggagctgtag catctctgga gcctgaacac

12421 ttaagttaag cacgactatt tcacgcagag ggcatgaatt c

(2) INFORMATION FOR SEQ ID NO: 42: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1251 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 42: 1 ggagctgttt acccccactc taataggggt tcaatataaa aagccggcag agagctgtcc

61 aagtcagacg cgcctctgca tctgcgccag gcgaacgggt cctgcgcctc ctgcagtccc

121 agctctccac caccgccgcg tgcgcctgca gacgctccgc tcgctgcctt ctctcctggc

181 aggcgctgcc ttttctcccc gttaaagggc acttgggctg aaggatcgct ttgagatctg

241 aggaacccgc agcgctttga gggacctgaa gctgtttttc ttcgttttcc tttgggttca

301 gtttgaacgg gaggtttttg atcccttttt ttcagaatgg attatttgct catgattttc

361 tctctgctgt ttgtggcttg ccaaggagct ccagaaacag cagtcttagg cgctgagctc

421 agcgcggtgg gtgagaacgg cggggagaaa cccactccca gtccaccctg gcggctccgc

481 cggtccaagc gctgctcctg ctcgtccctg atggataaag agtgtgtcta cttctgccac

541 ctggacatca tttgggtcaa cactcccgag cacgttgttc cgtatggact tggaagccct

601 aggtccaaga gagccttgga gaatttactt cccacaaagg caacagaccg tgagaataga

661 tgccaatgtg ctagccaaaa agacaagaag tgctggaatt tttgccaagc aggaaaagaa

721 ctcagggctg aagacattat ggagaaagac tggaataatc ataagaaagg aaaagactgt

781 tccaagcttg ggaaaaagtg tatttatcag cagttagtga gaggaagaaa aatcagaaga

841 agttcagagg aacacctaag acaaaccagg tcggagacca tgagaaacag cgtcaaatca

901 tcttttcatg atcccaagct gaaaggcaag ccctccagag agcgttatgt gacccacaac

961 cgagcacatt ggtgacagac ttcggggcct gtctgaagcc atagcctcca cggagagccc

1021 tgtggccgac tctgcactct ccaccctggc tgggatcaga gcaggagcat cctctgctgg

1081 ttcctgactg gcaaaggacc agcgtcctcg ttcaaaacat tccaagaaag gttaaggagt

1141 tcccccaacc atcttcactg gcttccatca gtggtaactg ctttggtctc ttctttcatc

1201 tggggatgac aatggacctc tcagcagaaa cacacagtca cattcgaatt c

(2) INFORMATION FOR SEQ ID NO: 43: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1166 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 43: 1 ctgcgccagg cgaacgggtc ctgcgcctcc tgcagtccca gctctccacc gccgcgtgcg

61 cctgcagacg ctccgctcgc tgccttctct cctggcaggc gctgcctttt ctccccgtta 121 aagggcactt gggctgaagg atcgctttga gatctgagga acccgcagcg ctttgaggga 181 cctgaagctg tttttcttcg ttttcctttg ggttcagttt gaacgggagg tttttgatcc 241 ctttttttca gaatggatta tttgctcatg attttctctc tgctgtttgt ggcttgccaa 301 ggagctccag aaacagcagt cttaggcgct gagctcagcg cggtgggtga gaacggcggg 361 gagaaaccca ctcccagtcc accctggcgg ctccgccggt ccaagcgctg ctcctgctcg 421 tccctgatgg ataaagagtg tgtctacttc tgccacctgg acatcatttg ggtcaacact 481 cccgagcacg ttgttccgta tggacttgga agccctaggt ccaagagagc cttggagaat 541 ttacttccca caaaggcaac agaccgtgag aatagatgcc aatgtgctag ccaaaaagac 601 aagaagtgct ggaatttttg ccaagcagga aaagaactca gggctgaaga cattatggag 661 aaagactgga ataatcataa gaaaggaaaa gactgttcca agcttgggaa aaagtgtatt 721 tatcagcagt tagtgagagg aagaaaaatc agaagaagtt cagaggaaca cctaagacaa 781 accaggtcgg agaccatgag aaacagcgtc aaatcatctt ttcatgatcc caagctgaaa 841 ggcaagccct ccagagagcg ttatgtgacc cacaaccgag cacattggtg acagacttcg 901 gggcctgtct gaagccatag cctccacgga gagccctgtg gccgactctg cactctccac 961 cctggctggg atcagagcag gagcatcctc tgctggttcc tgactggcaa aggaccagcg 1021 tcctcgttca aaacattcca agaaaggtta aggagttccc ccaaccatct tcactggctt 1081 ccatcagtgg taactgcttt ggtctcttct ttcatctggg gatgacaatg gacctctcag 1141 cagaaacaca cagtcacatt cgaattc

(2) INFORMATION FOR SEQ ID NO: 44: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14878 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 44:

1 gatatcctat taatacagag atacagaaag aaatacataa aaaatagttt tatcaaatac

61 tttccagcat tcaagtgtag cctcaaaagc aagaataggc caggagtggt ggctcacgct

121 gtaatccaca gcactgtggg aggccaaggt aagaggattg cttgaggcca ggatttcaag

181 accagcctag gcaacatagt gagatcccta tctctacgaa aaaattttaa aacttagctg EPI-109 1202

241 ggcatggtgc ttgagcctgt tgtcccagct actcaggagg tgaagtagga gtgtcacttg 301 agcccaggag gttgaggctg cagtgagcta taactgcacc actgcactcc agccttggag 361 acagagtgag accctgtccc caaaaaaatt aaaattgaga aaaaaaaaaa ggcaagaaca 421 gccacagcaa actttctatt ggggaaaaaa aaaaatcctc ctctttacat ctctcccttc 481 cttcccttcc ctttctgaga gtgactgtgg ccaaaaggag cattttcccc ctgcagtcct 541 ctgaggggtg gggtggggct atgaagctat ccttcatatt cactcctttg tccagctctt 601 ttcacctcta gttcttctcc ccgcatctct gtctagcagt gccttaagtg gaggaggggt 661 gggggcatca agcttgtaaa actggtttgt tggggttctc cttctcccct catttcttga 721 ttcttgggaa aatgtcttgc tgggaggctg cctggcgagt gccctagctg ccttctgtgg 781 gcttgaatgg ggcttccctc tgcccctaca ggaggaaaag ggagctgctg ccagagggag 841 aaatggagag atggacagag aaggcaggtg ccacccctcg cccctgacac acaaagaaaa 901 agacacggaa attctctctc tctcttctct tctcctatct ctctctctct ccctctctct 961 ctctctctct ctctctctca cacacacaca cacacacaca cacacacaca caggcgcgcg 1021 ccgcgcgcgc aggcacacgt cttgcaaatt caggattcaa agagacaggg gcaccattat 1081 atttggcacg gtggggcctt ccaggtctga aatcctgcat tcttccttac tatttacttt 1141 ccccgagctc gagaagggcc aggtgtgggc ggatggctgg ccacgttttg tgtttccaat 1201 tcatattcac gggatgacac agacggggcg tggtgagtgc tgttggaggc gcttgggcag 1261 tttcattttg ccccacttct ccacctgaag gctgggcgtt gctggaacct gcaggggcag 1321 cctcagcaag gtggggtggc gtggagtggg gtgggagaag ggactccagc tgaagtagaa 1381 cccaggctgg acctgagaat attggggagg gcatgggcgg tggtttccgg gtaggggcct 1441 tgaggacatg ttggtcctga ctgttgtcag tgtttggtca aagttgccaa aaggttaaaa 1501 aaaaaaaagt agggggagtc cctgccaaga catatttccc aggccacctt tcttccgcgg 1561 gagtgttggg ggggaggcgc tgcttggaac ctgtgaatgt gacatcagct ctcctctcct 1621 ctcccaaggt cggctttgga gagggaggtc agggcaccct tgcctggcac aggcacgctg 1681 gcttccggct cagtgccgcc tgctctccgg gagctgtgcg ctccctgggc cccggggcta 1741 ggctgaggta agcgcacagc ggaggccagg cgcgccggca gaggcctggg ggatagggtg 1801 gaggcatctc tgggtgtggg tgtgggtgtg ggtgtgggag ggagagttct tgcctctctc 1861 tctcccatct ccaactcttg cttcagtggc tcttttagag gatgcatgtc attatggacc 1921 tgtcgctgcc actgtccctg ttcccccagc tgtgacttcg agggaggtct ggggatctga 1981 gtctgtccaa acccacggct ttgctgttgg gataaaaact gtccttttga ttttagaagg 2041 aggagggaaa aaaggtttcc cagcatgtgt gttgtgccag tcttggaaat tcatccgtgc 2101 ttgaattcca ccctccatcc ccagaaaaac tggagtaaaa caaaaagagg agatggacaa 2161 agtgtgtatt tgatggcatc ccctgggaag agactctaaa tttatcccat aggtcttact 2221 gggccactgt gagcgctttg gtggagaaca aacaaaaatt ctgggtgctc agttgtctaa 2281 cctgaaaaat gggactagcg gaaaaagcca atgtgttcca tgcacctttt gctttcttta 2341 ttaaggcatg atgtcacctg tacagtaact gccctgtgtg tacttcaggg ggggatttca 2401 aggttagata gacaggaaat tgttttgaaa atgtaaacac attattaaat gtgaagtatt 2461 atctgattcc ttgttcgaat ggcatttcct tctcagcacc accttccttg catattcact 2521 taaccttgta caagaacacc tttttgccct aaatgaagac acccccccaa aaaaaagagt 2581 cccagaaaat atgtccctgc ttgtgcggga ataaatagaa tattctgagg tgcattcctc 2641 cttcctatgt taggcaacat tccttgaccc tcctcggccc ccaagccagg ttgcgttttt 2701 ttctgccatt tagaagggtt ttcctttttg tcctagtaaa acatcagccc ctgtagctct 2761 tcatctcccc ctggtgttct tctcccgcca tgtcttaaga ttggtggcac cgaccaatct 2821 taagatttaa gttctgtgtg aaaaacacct ttgcttttca atcagtttat cagcctcctc 2881 cgcaggggaa tgtggacaca caaaagaact tatcggggct tctcatcagt gatagggaaa 2941 agactggcat gtgcctaaac gagctctgat gttattttta agctcccttt cttgccaatc 3001 cctcacggat ctttctccga tagatgcaaa gaacttcagc aaaaaagacc cgcaggaagg 3061 ggcttgaaga gaaaagtacg ttgatctgcc aaaatagtct gacccccagt agtgggcagt 3121 gacgagggag agcattccct tgtttgactg agactagaat cggagagaca taaaaggaaa 3181 atgaagcgag caacaattaa aaaaaattcc ccgcacacaa caatacaatc tatttaaact 3241 gtggctcata cttttcatac caatggtatg actttttttc tggagtcccc tcttctgatt 3301 cttgaactcc ggggctggca gcttgcaaag gggaagcgga ctccagcact gcacgggcag 3361 gtttagcaaa ggtctctaat gggtattttc tttttcttag ccctgccccc gaattgtcag 3421 acggcgggcg tctgcttctg aagttagcag tgatttcctt tcgggcctgg cttatctccg 3481 gctgcacgtt gcctgttggt gactaataac acaataacat tgtctggggc tggaataaag 3541 tcggagctgt ttacccccac tctaataggg gttcaatata aaaagccggc agagagctgt 3601 ccaagtcaga cgcgcctctg catctgcgcc aggcgaacgg gtcctgcgcc tcctgcagtc 3661 ccagctctcc accgccgcgt gcgcctgcag acgctccgct cgctgccttc tctcctggca 3721 ggcgctgcct tttctccccg ttaaagggca cttgggctga aggatcgctt tgagatctga 3781 ggaacccgca gcgctttgag ggacctgaag ctgtttttct tcgttttcct ttgggttcag 3841 tttgaacggg aggtttttga tccctttttt tcagaatgga ttatttgctc atgattttct 3901 ctctgctgtt tgtggcttgc caaggagctc cagaaacagg taggcacgct cgttgacttg 3961 taagtctcgg aattacaagt tagtgtgttc ttatccacct tcatgctttt cttgcttcta 4021 tttttccccg ttctttttat gactgcagct tagagagcaa gtgtctgaga attattgctg 4081 aaacgtactt taagtcttct agtgtaaaat gtaaaattcc tctactgaat acaattaggt 4141 gcaattgact ataacatgac attaaaataa cttatcgttt tattattatt attccattat 4201 gtgtttcctt ggcttttaaa aaatgagaag agtatggaca tatacaattt agtcaaatgt 4261 atgtttgtaa tatatgtgtt tatacaggta cacaggccat ataggaactt aaatcttatt 4321 taaacactat tttaatagtg tgttaacgtg taaaatattt aagcattcca gcttgaagcc 4381 aaggaattgt atccagtcgt tcaagcaatg tatgttcagt aaaatcacct gcagagcaaa 4441 agtctgttga ctaactaccg cctcccccgc ccccccacca ccccccgcag gcggtttctg 4501 ggtgaagcag atgttttctt taaaatttgt catcattgac tttaggtttc ttttggcagg 4561 tttttggcac ccaaaacagt gtgagctctc ttttcagctt tattcacctg tgctgggagg 4621 ggagctagga taattcttgg ctgccgaagg atttaggcag tgcgtgtgca tctgcccggg 4681 tcccccccgt ttttagggtc agtgcacttt ttttgtcttt tcgtgaccct gactaaagag EPI-109 1203

4741 aaaggatgtc aagggaatga aaatcctgga atgtgtctga tcatttgaaa tgtacaaaat 4801 tgggcagata agctgcatgg ctaaattgtt aggaggaaga ggcaaggcag tagtggagaa 4861 gggggaggca gtggatccca cacaagcctg atgcccaggg attcggaatt caaaatcccc 4921 ccagcctacc ttcagtcccc tgacctgctt ctcagcccca ccttaggtca ctggtttcta 4981 tggagttacc ctactgaatt gaatattgaa tagttaattt ctctctccaa tcattttccc 5041 cacctaattt tgaaagatat acatcatctg gggtaccctg tgccctacac agcatgtgaa 5101 gtggatgggt accccctaaa gagagggtca tcctgaatgg ggaagtggcc ccaaagctag 5161 gaataactgt gatttcttgt ctttagtcat gtgccaatgt taagtaagct tcagtggata 5221 gtgctgtcct accaagttcc ttgtagaagc cagccggatt ttcaacaggc agcattccac 5281 agcatttccc tgagcctgct tcaagagggg tgggggaagt cccttttcag gtgtttatct 5341 cctctgcatt tgtgtaatct ccctgaaggt ggataagcca agggcatgag ggggaggcaa 5401 aaggtgaact catgttaagg agggaaaaaa ataaagagcc cttttttctg tgtttcttgc 5461 tgatggcagg ctgtgtgctt catctgcttt tatctgctct gctagctctg actctactgt 5521 gatccagcat gtctctcggc gtttgaggag acatccccca ctgacctgct ctttctctcc 5581 ccagcagtct taggcgctga gctcagcgcg gtgggtgaga acggcgggga gaaacccact 5641 cccagtccac cctggcggct ccgccggtcc aagcgctgct cctgctcgtc cctgatggat 5701 aaagagtgtg tctacttctg ccacctggac atcatttggg tcaacactcc cgagtaagtc 5761 tctagagggc attgtaaccc tattcattca ttagcgctgg ctccactgga gcccagtttt 5821 agagtttctt ttctagggac tctgaaggta gtccttctaa caccatccaa gtgcctcagt 5881 ggggacagtt tccctctatt cctgaaaata acgacagctt cgttcttagc aaccaagggg 5941 agggtcttct gaggccccgt agctcaggct actcatgatg ggacaagcag gaggccactg 6001 cacgtttcaa atgaggaact ttcagtgaga gggcctcagg gggacactct cacagtggca 6061 tctgatgggg tttcgggaat aattgccgag gtcagatgtg ggttagtgca acctgtgctt 6121 ctcatgggag ggtggagact gagaggcaga agtgatgata tagagggtta gaatcactta 6181 attttagtta cagaaaaacc taggctcaaa gtgttgaagc catttgtgca ggagtgagtt 6241 tgtagcagag ctagaactgg agcccggatt tcctttgctg ctatattttc cctttagaaa 6301 tgcccatttc agaactgaaa tagaaatact gtccataggc ttctctttca cctacagaga 6361 agaaaagcag atttcctcct tctgccctgg acactagttc atcatctgtc ggaagcagtc 6421 ataaacaagc acacatttac tatgcataca atgtaccgtt atgacaaagg aggaccaaaa 6481 tccaaacaat atcaaaccac accaaaaacc acaaggagcc taataattac taaggtgata 6541 cttccaaagg gaggacttta tttcttagat gagaatgaaa atggacacat tggaaattat 6601 tggagagccc tctggctatg agtccttcca caaccatatg gtaccaccga ctggcaggag 6661 aaatgtgtga acatgtgcct cctctcccca accactgggg ccggtggggt gacggtggca 6721 cttttagcag tatcctccgt ggtttgagtt gaaaataagt tttaaaaatc ctgtgagtca 6781 tggttttgca ttgaaacctc ttcccactgt gtacccacaa atagttaact aaatagacca 6841 ttagaaaagg aagaaaatat aaagcagatg ccaagcagag atgtcctaat ttttgacaaa 6901 aaagcaatgt tgcttgtgtc aagaagaaac tgaactttgt gaagagttga aatggaattc 6961 cactgaatta gaaaaacttg ttttctcctg cctggataca tacagtcagg gccattgatg 7021 cacaggtgtt cctggctgtt gttacacttt accctctgaa atgatgctcc caagtgctat 7081 gtgatgagct ccttgtgtgc ccagtggaat aggtgtgtcc atgtgtcatt ttaaagacta 7141 ttaattacac taatatagtt tctttctctc tttggataat aggcacgttg ttccgtatgg 7201 acttggaagc cctaggtcca agagagcctt ggagaattta cttcccacaa aggcaacaga 7261 ccgtgagaat agatgccaat gtgctagcca aaaagacaag aagtgctgga atttttgcca 7321 agcaggaaaa gaactcaggt gagcagaaac acctttgctt ttcaatcagt ttaacagcct 7381 cctgaactcc ttcctatcat ggtactgcct tcctgtttta gagagactaa cagagacatt 7441 gaaagtcagg gtaaagctga atataacatt gctgaaatgt ttttccttgt gtattttaac 7501 agggctgaag acattatgga gaaagactgg aataatcata agaaaggaaa agactgttcc 7561 aagcttggga aaaagtgtat ttatcagcag ttagtgagag gaagaaaaat cagaagaagt 7621 tcagaggaac acctaagaca aaccaggtaa gagggaagga agaaaaatta ggtaagaggt 7681 tcacaagaac aactagcccc agtcagtgat gccagcagcc tgttcctcca gcccttctta 7741 cccgggcagg tgaaagactt agaaaacagt agcagaggag atctatgcat cctatagatt 7801 aaaaggagca aaagaatccc tcttaaatat ttccatgaag ctctggaatg caaaccgatg 7861 tcctctgtac ctttagcaca taccatttca tctacaggta gatttcccaa ccaaaatata 7921 tccagagatg cctttgtcat tgggttatat acagcctttg cctctctgag tcaatgtatt 7981 taccactttc cctgagaaat cgaaaatcat tttggggagc ggacatttag aaaaagaatc 8041 aaagtgtcat ggataatcaa attcttcaat aagttgcagt tattcagatg gccaaaggaa 8101 aaataaagtc attagatagg gttggtagaa tttagaacat gctgtttttc aggtttatgg 8161 tctttttttt tttttttttt tttttttaaa tagggaaatg tgtttggtgc agagccaatg 8221 tcattccaaa aagctctctc ttttcctggt cagtcatgtg ctgggacaga gaagggatct 8281 ggattaggca acatcataga gttgctctga gctgctcttt ggtgataacc cttccaaatc 8341 ctaaactttt tggaattcac aagctcaaag gaggaaacct actctctgat ctaccacatg 8401 ttctgcattt ttctatcatg gtctatggaa acttctctta gaaatccagt ggcaagaagt 8461 tctatgatta aagtgttctg agctcaggcc aggcagtcat gaactacttc tgagttgttt 8521 actactgatt tgtggggcag cctcagctat cggtttcttc acacctgctt atgagagtat 8581 ccatatttat ggtcgcaggc agtaatgctc cccacgagat cagtttctga actaacctgg 8641 aattttttat gggtttttat tatgccaact attaaatcaa cattacagtt cttccctctg 8701 tatttctcct gtaaaacatt aggcctgcaa aaaaaaaaaa tctttttaaa aataattgcc 8761 ataaagtatt tgctctgggc ctactgtatg cttcttttyt ttttctctct tttcaactaa 8821 gtcaccgtca atttattaag atggccataa ctattcaaaa cctatgctga gttcctcaag 8881 gcagggtcgc atagtgatga aggttgggat ggggctacgg aagaaaccag aacaactcta 8941 gtttatttaa aacctgtatt tactgcccac ttccccttag acttgaccat atgacccctt 9001 gctccccatt ctaagcatag gggcaggctt tatttttaca atggtaatag atgatatcac 9061 ttgaggtttt atcaaagagt tgcggcgggt ggtgaaagtt cacaaccaga ttcaggtttt 9121 gtttgtgcca gattctaatt ttacatgttt cttttgccaa agggtgattt ttttaaaata 9181 acatttgttt tctcttatct tgctttatta ggtcggagac catgagaaac agcgtcaaat EPI-109 1204

9241 catcttttca tgatcccaag ctgaaaggca agccctccag agagcgttat gtgacccaca

9301 accgagcaca ttggtgacag accttcgggg cctgtctgaa gccatagcct ccacggagag

9361 ccctgtggcc gactctgcac tctccaccct ggctgggatc agagcaggag catcctctgc

9421 tggttcctga ctggcaaagg accagcgtcc tcgttcaaaa cattccaaga aaggttaagg

9481 agttccccca accatcttca ctggcttcca tcagtggtaa ctgctttggt ctcttctttc

9541 atctggggat gacaatggac ctctcagcag aaacacacag tcacattcga attcgggtgg

9601 catcctccgg agagagagag aggaaggaga ttccacacag gggtggagtt tctgacgaag

9661 gtcctaaggg agtgtttgtg tctgactcag gcgcctggca catttcaggg agaaactcca

9721 aagtccacac aaagattttc taaggaatgc acaaattgaa aacacactca aaagacaaac

9781 atgcaagtaa agaaaaaaaa aagaaagact tttgtttaaa tttgtaaaat gcaaaactga

9841 atgaaactgt tactaccata aatcaggata tgtttcatga atatgagtct acctcaccta

9901 tattgcactc tggcagaagt atttcccaca tttaattatt gcctccccaa actcttccca

9g61 cccctgctgc cccttcctcc atcccccata ctaaatccta gcctcgtaga agtctggtct

10021 aatgtgtcag cagtagatat aatattttca tggtaatcta ctagctctga tccataagaa

10081 aaaaaagatc attaaatcag gagattccct gtccttgatt tttggagaca caatggtata

10141 gggttgttta tgaaatatat tgaaaagtaa gtgtttgtta cgctttaaag cagtaaaatt

10201 attttccttt atataaccgg ctaatgaaag aggttggatt gaattttgat gtacttattt

10261 ttttatagat atttatattc aaacaattta ttccttatat ttaccatgtt aaatatctgt

10321 ttgggcaggc catattggtc tatgtatttt taaaatatgt atttctaaat gaaattgaga

10381 acatgctttg ttttgcctgt caaggtaatg actttagaaa ataaatattt ttttccttac

10441 tgtactgatt tggaatcatt actgaaattt gtaaggagtg ggccaacgtg attaagtacc

10501 ataaaggcaa ataaatggtt aaagacggtt tcatagaaaa gtgacaatta gaaggatatt

10561 acggtctaag ctaattatat aaagaatttt atctgtatct taaatgttga ttttatactg

10621 cattgaggta aaaacacaaa acaaaaaagc agctttaaca cctctgtctt ctcttgggta

10681 gcagcctcct gcttctcctt cacctgaaaa attctccagg gacttcatcc attaacttgg

10741 ctcaggctat tggcaggatt cacagtttaa gctgatggtg tggtgagaga tgctttatcc

10801 atattaatgg actgaaggaa gtaatggcaa gacaaccccc caaaacatac ctaattatac

10861 aaagttatat accaaagttg cttttagaaa atggcctgct cagagcaagt agaggtttcc

10921 aatggctttt tattttctca cattaaggat gttgtttctt aaggaacatt gagtaccatt

10981 gcttcttcgt gatagcctag gactgccgtg tgcccatgga ggtagagaca ccaggtactg

11041 attctaggtc ctctgccaca aagcaccact tcctctccac tttgccttgg ctggccttgt

11101 cagctcactg gagagcacag tattgcaatt gcagtattgc aaatggtcac tactaactga

11161 attctctaag agcttgatta gccctcgaga atcttccttg cccttctcta atagtgtctg

11221 aaggaattcc tggcatttaa caaatattag catgtagtga tcactgtcgt cctaacagtg

11281 acacatcaga aggatttcaa ataacagtct tcaggcatgc gtaatcaatg tcctgtgcag

11341 agtctccgtc ctcattgatc ctcatttttc tctttaaggc acagtccaat gtctttgggg

11401 aattgtttat aaagcttact ttatccataa actgtttctc agtgcgtgac tctgaagaaa

11461 attttgaagt tttgcccatg ttgacaaggt gcttggtctg aacttggcca gtatttaatc

11521 ttgagcaaac gattcaattt ccttctatcg tgagttttct catctatgaa acaagggagt

11581 tgaggggagt ttctttcata cctctgagaa agagtttgag attacataaa gaagttgaag

11641 tggcatgaaa aaaaataaag atctgagctt agaagacatg gatctaatac atttaagagg

11701 aagtcagaat cagagaagcc actgaacaaa acagtccaaa cggagcatag taagtcagat

11761 tgatgagttt tggttgggtt tttcatcagt caaacccttg agcccccctt tcccatgctt

11821 cctgcttcag tatccagtag gaaaaatgaa agggatgatg tagacactct agggcatgag

11881 gatttgcagt aaataagttg ggagactcac agaaaattaa tatttttcaa acatgaagac

11941 gaaacattca attatattac agtccacatc agcttgaagg gtaaactgat gggatgatct

12001 gtcacatttc ttgctctgtt tccagtaaaa gcatggtttc tggaaaccca cttaggacag

12061 ctttctctct ttacactgat agcccaggca agctttgatc tcagaactcc agaaaccaga

12121 gaactctagg tggaatgtgg taacttttgc cagggcagag ggaacaccta ctaataggta

12181 cttcatttgc accaccagag attggcatct tttttgatgg atccactggc tttgatactg

12241 cctgtactcc cccaaaacac agcttgggta ttggactaat ctagagctcc ctcaggagaa

12301 ctcttgctga cattaagaaa gagcaacatt ttgtctttcc aggtgaaaat ccaaggccaa

12361 aaagggagtg actcacctaa gatcacagaa ggagctgtag catctctgga gcctgaacac

12421 ttaagttaag cacgactatt tcacgcagag ggcatgaatt c ggagctgttt acccccactc taataggggt tcaatataaa aagccggcag agagctgtcc

61 aagtcagacg cgcctctgca tctgcgccag gcgaacgggt cctgcgcctc ctgcagtccc

121 agctctccac caccgccgcg tgcgcctgca gacgctccgc tcgctgcctt ctctcctggc

181 aggcgctgcc ttttctcccc gttaaagggc acttgggctg aaggatcgct ttgagatctg

241 aggaacccgc agcgctttga gggacctgaa gctgtttttc ttcgttttcc tttgggttca

301 gtttgaacgg gaggtttttg atcccttttt ttcagaatgg attatttgct catgattttc

361 tctctgctgt ttgtggcttg ccaaggagct ccagaaacag cagtcttagg cgctgagctc

421 agcgcggtgg gtgagaacgg cggggagaaa cccactccca gtccaccctg gcggctccgc

481 cggtccaagc gctgctcctg ctcgtccctg atggataaag agtgtgtcta cttctgccac

541 ctggacatca tttgggtcaa cactcccgag cacgttgttc cgtatggact tggaagccct

601 aggtccaaga gagccttgga gaatttactt cccacaaagg caacagaccg tgagaataga

661 tgccaatgtg ctagccaaaa agacaagaag tgctggaatt tttgccaagc aggaaaagaa

721 ctcagggctg aagacattat ggagaaagac tggaataatc ataagaaagg aaaagactgt

781 tccaagcttg ggaaaaagtg tatttatcag cagttagtga gaggaagaaa aatcagaaga

841 agttcagagg aacacctaag acaaaccagg tcggagacca tgagaaacag cgtcaaatca

901 tcttttcatg atcccaagct gaaaggcaag ccctccagag agcgttatgt gacccacaac

961 cgagcacatt ggtgacagac ttcggggcct gtctgaagcc atagcctcca cggagagccc

1021 tgtggccgac tctgcactct ccaccctggc tgggatcaga gcaggagcat cctctgctgg

1081 ttcctgactg gcaaaggacc agcgtcctcg ttcaaaacat tccaagaaag gttaaggagt

1141 tcccccaacc atcttcactg gcttccatca gtggtaactg ctttggtctc ttctttcatc

1201 tggggatgac aatggacctc tcagcagaaa cacacagtca cattcgaatt c EPI-109 1205

1 ctgcgccagg cgaacgggtc ctgcgcctcc tgcagtccca gctctccacc gccgcgtgcg

61 cctgcagacg ctccgctcgc tgccttctct cctggcaggc gctgcctttt ctccccgtta

121 aagggcactt gggctgaagg atcgctttga gatctgagga acccgcagcg ctttgaggga

181 cctgaagctg tttttcttcg ttttcctttg ggttcagttt gaacgggagg tttttgatcc

241 ctttttttca gaatggatta tttgctcatg attttctctc tgctgtttgt ggcttgccaa

301 ggagctccag aaacagcagt cttaggcgct gagctcagcg cggtgggtga gaacggcggg

361 gagaaaccca ctcccagtcc accctggcgg ctccgccggt ccaagcgctg ctcctgctcg

421 tccctgatgg ataaagagtg tgtctacttc tgccacctgg acatcatttg ggtcaacact

481 cccgagcacg ttgttccgta tggacttgga agccctaggt ccaagagagc cttggagaat

541 ttacttccca caaaggcaac agaccgtgag aatagatgcc aatgtgctag ccaaaaagac

601 aagaagtgct ggaatttttg ccaagcagga aaagaactca gggctgaaga cattatggag

661 aaagactgga ataatcataa gaaaggaaaa gactgttcca agcttgggaa aaagtgtatt

721 tatcagcagt tagtgagagg aagaaaaatc agaagaagtt cagaggaaca cctaagacaa

781 accaggtcgg agaccatgag aaacagcgtc aaatcatctt ttcatgatcc caagctgaaa

841 ggcaagccct ccagagagcg ttatgtgacc cacaaccgag cacattggtg acagacttcg

901 gggcctgtct gaagccatag cctccacgga gagccctgtg gccgactctg cactctccac

961 cctggctggg atcagagcag gagcatcctc tgctggttcc tgactggcaa aggaccagcg

1021 tcctcgttca aaacattcca agaaaggtta aggagttccc ccaaccatct tcactggctt

1081 ccatcagtgg taactgcttt ggtctcttct ttcatctggg gatgacaatg gacctctcag

1141 cagaaacaca cagtcacatt cgaattc

(2) INFORMATION FOR SEQ ID NO: 45: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 718 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 45: 1 aggggcagct ggatcagttc tcacaggagc cacagctcag agactgggaa acatggttcc

61 aaaactgttc acttcccaaa tttgtctgct tcttctgttg gggcttatgg gtgtggaggg

121 ctcactccat gccagacccc cacagtttac gagggctcag tggtttgcca tccagcacat

181 cagtctgaac ccccctcgat gcaccattgc aatgcgggca attaacaatt atcgatggcg

241 ttgcaaaaac caaaatactt ttcttcgtac aacttttgct aatgtagtta atgtttgtgg

301 taaccaaagt atacgctgcc ctcataacag aactctcaac aattgtcatc ggagtagatt

361 ccgggtgcct ttactccact gtgacctcat aaatccaggt gcacagaata tttcaaactg

421 caggtatgca gacagaccag gaaggaggtt ctatgtagtt gcatgtgaca acagagatcc

481 acgggattct ccacggtatc ctgtggttcc agttcacctg gataccacca tctaagctcc

541 tgtatcagca gtcctcatca tcactcatct gccaagctcc tcaatcatag ccaagatccc

601 atccctccat gtactctggg tatcagcaac tgtcctcatc agtctccata ccccttcagc

661 tttcctgagc tgaagtccct tgtgaaccct gcaataaact gctttgcaaa ttcaaaaa

(2) INFORMATION FOR SEQ ID NO: 46: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 725 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 46: 1 gaacaaccag ctggatcagt tctcacagga gccacagctc agagactggg aaacatggtt

61 ccaaaactgt tcacttccca aatttgtctg cttcttctgt tggggcttat gggtgtggag

121 ggctcactcc atgccagacc cccacagttt acgagggctc agtggtttgc catccagcac

181 atcagtctga acccccctcg atgcaccatt gcaatgcggg caattaacaa ttatcgatgg

241 cgttgcaaaa accaaaatac ttttcttcgt acaacttttg ctaatgtagt taatgtttgt

301 ggtaaccaaa gtatacgctg ccctcataac agaactctca acaattgtca tcggagtaga

361 ttccgggtgc ctttactcca ctgtgacctc ataaatccag gtgcacagaa tatttcaaac

421 tgcaggtatg cagacagacc aggaaggagg ttctatgtag ttgcatgtga caacagagat

481 ccacgggatt ctccacggta tcctgtggtt ccagttcacc tggataccac catctaagct

541 cctgtatcag cagtcctcat catcactcat ctgccaagct cctcaatcat agccaagatc

601 ccatccctcc atgtactctg ggtatcagca actgtcctca tcagtctcca taccccttca

661 gctttcctga gctgaagtcc cttgtgaacc ctgcaataaa ctgctttgca aattc

(2) INFORMATION FOR SEQ ID NO: 47: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1452 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 7: ctgccagcag cgtatagttt tcacccagag tccagatccc accggcaaaa ctctgtctaa

61 cacaggatga cttggaatta gagtccgtat agcagaaaga gcagcagggc tgtccttggg

121 tatccgttgc tcagccaagt catcaaataa aaaggatgat tgcacaagtg gaccatgtgt

181 caatctgtgg gtttctgcat ggccagaccc accaagggaa gctttattta aacagttcca

241 agtaggggag accagctgcc cctgaacccc agaacaacca gctggatcag ttctcacagg

301 agccacagct cagagactgg gtaagtcaac aatccccaga gctgggacag gaggggcagc

361 gacagggcag cacctgaggg agaggtgagc tgaagttagt gcttaggaga tgtggcacac EPI-109 1206

421 tttggggaca ggaagaaaag gaaatgcgac cccagagtgg cagcagaggg gcctgtgggt

481 tgagacacta tagagtgtgt cataaccgag accggatagg ggagtagtta cttctcttct

541 tttcttacag gaaacatggt tccaaaactg ttcacttccc aaatttgtct gcttcttctg

601 ttggggctta tgggtgtgga gggctcactc catgccagac ccccacagtt tacgagggct

661 cagtggtttg ccatccagca catcagtctg aacccccctc gatgcaccat tgcaatgcgg

721 gcaattaaca attatcgatg gcgttgcaaa aaccaaaata cttttcttcg tacaactttt

781 gctaatgtag ttaatgtttg tggtaaccaa agtatacgct gccctcataa cagaactctc

841 aacaattgtc atcggagtag attccgggtg cctttactcc actgtgacct cataaatcca

901 ggtgcacaga atatttcaaa ctgcaggtat gcagacagac caggaaggag gttctatgta

961 gttgcatgtg acaacagaga tccacgggat tctccacggt atcctgtggt tccagttcac

1021 ctggatacca ccatctaagc tcctgtatca gcagtcctca tcatcactca tctgccaagc

1081 tcctcaatca tagccaagat cccatccctc catgtactct gggtatcagc aactgtcctc

1141 atcagtctcc ataccccttc agctttcctg agctgaagtc ccttgtgaac cctgcaataa

1201 actgctttgc aaattcatct ggaagtgtct gtgtgtcttc ctcggccgct ctgctgtcat

1261 ttagtgacaa tctgctctag agatttgggt ttatcatgaa tctctccccc tcaatatctg

1321 accaaattcc ttgattcccc catcatcctt catgtgatac ctgattccag gcctgcctta

1381 aaaaaaaatc caattgagtc aacttagcat tggtctccct agccttaata tctcctctaa

1441 gcaattttcc at

(2) INFORMATION FOR SEQ ID NO: 48: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2395 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 48: 1 aggggcagct ggatcagttc tcacaggagc cacagctcag agactgggaa acatggttcc

61 aaaactgttc acttcccaaa tttgtctgct tcttctgttg gggcttatgg gtgtggaggg 121 ctcactccat gccagacccc cacagtttac gagggctcag tggtttgcca tccagcacat 181 cagtctgaac ccccctcgat gcaccattgc aatgcgggca attaacaatt atcgatggcg 241 ttgcaaaaac caaaatactt ttcttcgtac aacttttgct aatgtagtta atgtttgtgg 301 taaccaaagt atacgctgcc ctcataacag aactctcaac aattgtcatc ggagtagatt 361 ccgggtgcct ttactccact gtgacctcat aaatccaggt gcacagaata tttcaaactg 421 caggtatgca gacagaccag gaaggaggtt ctatgtagtt gcatgtgaca acagagatcc 481 acgggattct ccacggtatc ctgtggttcc agttcacctg gataccacca tctaagctcc 541 tgtatcagca gtcctcatca tcactcatct gccaagctcc tcaatcatag ccaagatccc 601 atccctccat gtactctggg tatcagcaac tgtcctcatc agtctccata ccccttcagc 661 tttcctgagc tgaagtccct tgtgaaccct gcaataaact gctttgcaaa ttcaaaaa gaacaaccag ctggatcagt tctcacagga gccacagctc agagactggg aaacatggtt

61 ccaaaactgt tcacttccca aatttgtctg cttcttctgt tggggcttat gggtgtggag 121 ggctcactcc atgccagacc cccacagttt acgagggctc agtggtttgc catccagcac 181 atcagtctga acccccctcg atgcaccatt gcaatgcggg caattaacaa ttatcgatgg 241 cgttgcaaaa accaaaatac ttttcttcgt acaacttttg ctaatgtagt taatgtttgt 301 ggtaaccaaa gtatacgctg ccctcataac agaactctca acaattgtca tcggagtaga 361 ttccgggtgc ctttactcca ctgtgacctc ataaatccag gtgcacagaa tatttcaaac 421 tgcaggtatg cagacagacc aggaaggagg ttctatgtag ttgcatgtga caacagagat 481 ccacgggatt ctccacggta tcctgtggtt ccagttcacc tggataccac catctaagct 541 cctgtatcag cagtcctcat catcactcat ctgccaagct cctcaatcat agccaagatc 601 ccatccctcc atgtactctg ggtatcagca actgtcctca tcagtctcca taccccttca 661 gctttcctga gctgaagtcc cttgtgaacc ctgcaataaa ctgctttgca aattc ctgccagcag cgtatagttt tcacccagag tccagatccc accggcaaaa ctctgtctaa

61 cacaggatga cttggaatta gagtccgtat agcagaaaga gcagcagggc tgtccttggg

121 tatccgttgc tcagccaagt catcaaataa aaaggatgat tgcacaagtg gaccatgtgt

181 caatctgtgg gtttctgcat ggccagaccc accaagggaa gctttattta aacagttcca

241 agtaggggag accagctgcc cctgaacccc agaacaacca gctggatcag ttctcacagg

301 agccacagct cagagactgg gtaagtcaac aatccccaga gctgggacag gaggggcagc

361 gacagggcag cacctgaggg agaggtgagc tgaagttagt gcttaggaga tgtggcacac

421 tttggggaca ggaagaaaag gaaatgcgac cccagagtgg cagcagaggg gcctgtgggt

481 tgagacacta tagagtgtgt cataaccgag accggatagg ggagtagtta cttctcttct

541 tttcttacag gaaacatggt tccaaaactg ttcacttccc aaatttgtct gcttcttctg

601 ttggggctta tgggtgtgga gggctcactc catgccagac ccccacagtt tacgagggct

661 cagtggtttg ccatccagca catcagtctg aacccccctc gatgcaccat tgcaatgcgg

721 gcaattaaca attatcgatg gcgttgcaaa aaccaaaata cttttcttcg tacaactttt

781 gctaatgtag ttaatgtttg tggtaaccaa agtatacgct gccctcataa cagaactctc

841 aacaattgtc atcggagtag attccgggtg cctttactcc actgtgacct cataaatcca

901 ggtgcacaga atatttcaaa ctgcaggtat gcagacagac caggaaggag gttctatgta

961 gttgcatgtg acaacagaga tccacgggat tctccacggt atcctgtggt tccagttcac

1021 ctggatacca ccatctaagc tcctgtatca gcagtcctca tcatcactca tctgccaagc

1081 tcctcaatca tagccaagat cccatccctc catgtactct gggtatcagc aactgtcctc

1141 atcagtctcc ataccccttc agctttcctg agctgaagtc ccttgtgaac cctgcaataa

1201 actgctttgc aaattcatct ggaagtgtct gtgtgtcttc ctcggccgct ctgctgtcat

1261 ttagtgacaa tctgctctag agatttgggt ttatcatgaa tctctccccc tcaatatctg

1321 accaaattcc ttgattcccc catcatcctt catgtgatac ctgattccag gcctgcctta

1381 aaaaaaaatc caattgagtc aacttagcat tggtctccct agccttaata tctcctctaa

1441 gcaattttcc at EPI-109 1207

( 2 ) INFORMATION FOR SEQ ID NO : 49 : ' l ) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 694 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY, linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 49: 1 cacaggagct acagcgcgga gactggaaac atggttccaa aactgttcac ttcccaaatt

61 tgtctgcttc ttctgttggg gcttctggct gtggagggct cactccatgt caaacctcca

121 cagtttacct gggctcaatg gtttgaaacc cagcacatca atatgacctc ccagcaatgc

181 accaatgcaa tgcaggtcat taacaattat caacggcgat gcaaaaacca aaatactttc

241 cttcttacaa cttttgctaa cgtagttaat gtttgtggta acccaaatat gacctgtcct

301 agtaacaaaa ctcgcaaaaa ttgtcaccac agtggaagcc aggtgccttt aatccactgt

361 aacctcacaa ctccaagtcc acagaatatt tcaaactgca ggtatgcgca gacaccagca

421 aacatgttct atatagttgc atgtgacaac agagatcaac gacgagaccc tccacagtat

481 ccggtggttc cagttcacct ggatagaatc atctaagctc ctgtatcagc actcctcatc

541 atcactcatc tgccaagctc ctcaatcata gccaagatcc catctctcca tatactttgg

601 gtatcagcat ctgtcctcat cagtctccat accccttcag ctttcctgag ctgaagtgcc

661 ttgtgaaccc tgcaataaac tgctttgcaa attc

(2) INFORMATION FOR SEQ ID NO: 50: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1489 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 50: 1 ctgcaggcag catatagttt tcatccagag tttggatcta accagcaaaa ctctgtctta

61 cacaggatga cttggaatta gagtccttat agcagaaaga gcagcagggc tgtccttggg

121 tatccgttgc tcagccaagt catcaaataa aaaggatgat tgcacaagtg gactatgtac

181 caatctgtgg gtttctgcat ggccaagagc cagaccctcc ctctgggctc tgctggccca

241 acccaccaag ggatgcttta tttaaacagt tccaagtagg ggagaccagc tgcccctgaa

301 ccccagaaca accagctgga tcagttctca caggagctac agcgcggaga ctgggtaagt

361 caacgatccc cagagctggg acagaagggg cagcaatggg gcagcaactg agggagaaga

421 gagctgacgt tagtgcttag gagacgttgc acactttgca gacaggaagt aaaggaaatg

481 ggaccccaga gtggccgcag aggggcctgt ggggtaagac actacagtgt gtgtcataac

541 caagacccga tcagggagta gttacttctc ttcttttctt acaggaaaca tggttccaaa

601 actgttcact tcccaaattt gtctgcttct tctgttgggg cttctggctg tggagggctc

661 actccatgtc aaacctccac agtttacctg ggctcaatgg tttgaaaccc agcacatcaa

721 tatgacctcc cagcaatgca ccaatgcaat gcaggtcatt aacaattatc aacggcgatg

781 caaaaaccaa aatactttcc ttcttacaac ttttgctaac gtagttaatg tttgtggtaa

841 cccaaatatg acctgtccta gtaacaaaac tcgcaaaaat tgtcaccaca gtggaagcca

901 ggtgccttta atccactgta acctcacaac tccaagtcca cagaatattt caaactgcag

961 gtatgcgcag acaccagcaa acatgttcta tatagttgca tgtgacaaca gagatcaacg

1021 acgagaccct ccacagtatc cggtggttcc agttcacctg gatagaatca tctaagctcc

1081 tgtatcagca ctcctcatca tcactcatct gccaagctcc tcaatcatag ccaagatccc

1141 atctctccat atactttggg tatcagcatc tgtcctcatc agtctccata ccccttcagc

1201 tttcctgagc tgaagtgcct tgtgaaccct gcaataaact gctttgcaaa ttcatctgaa

1261 agtgtctgtg tgtcttcatt agccgctctg ctgtcattta gtgacaatct actctagaga

1321 tttttcttcc tctaacctga gacttccggg aaacagagag atttgaagat aagagacgct

1381 ttctgtcatg aaacagcaca gtcttatccc tctccctgct ttaggctgag aagctgaggt

1441 ctcaaccgat atctagcaac tgtcgaagac tcttgctttg atcaagctt

(2) INFORMATION FOR SEQ ID NO: 51: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 735 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 51: 1 gctgcccctg aaccccagaa caaccagctg gatcagttct cacaggagct acaggccgga

61 gactgggaaa catggttcca aaactgttca cttcccaaat ttgtctgctt cttctgttgg

121 ggcttctggc tgtggagggc tcactccatg tcaaacctcc acagtttacc tgggctcaat

181 ggtttgaaac ccagcacatc aatatgacct cccagcaatg caccaatgca atgcaggtca

241 ttaacaatta tcaacggcga tgcaaaaacc aaaatacttt ccttcttaca acttttgcta

301 acgtagttaa tgtttgtggt aacccaaata tgacctgtcc tagtaacaaa actcgcaaaa

361 attgtcacca cagtggaagc caggtgcctt taatccactg taacctcaca actccaagtc

421 cacagaatat ttcaaactgc aggtatgcgc agacaccagc aaacatgttc tatatagttg

481 catgtgacaa cagagatcaa cgacgagacc ctccacagta tccggtggtt ccagttcacc

541 tggatagaat catctaagct cctgtatcag cactcctcat catcactcat ctgccaagct

601 cctcaatcat agccaagatc ccatctctcc atatactttg ggtatcagca tctgtcctca

661 tcagtctcca taccccttca gctttcctga gctgaagtgc cttgtgaacc ctgcaataaa 721 ctgctttgca aattc EPI-109 1208

(2) INFORMATION FOR SEQ ID NO: 52: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2918 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 52: 1 cacaggagct acagcgcgga gactggaaac atggttccaa aactgttcac ttcccaaatt

61 tgtctgcttc ttctgttggg gcttctggct gtggagggct cactccatgt caaacctcca 121 cagtttacct gggctcaatg gtttgaaacc cagcacatca atatgacctc ccagcaatgc 181 accaatgcaa tgcaggtcat taacaattat caacggcgat gcaaaaacca aaatactttc 241 cttcttacaa cttttgctaa cgtagttaat gtttgtggta acccaaatat gacctgtcct 301 agtaacaaaa ctcgcaaaaa ttgtcaccac agtggaagcc aggtgccttt aatccactgt 361 aacctcacaa ctccaagtcc acagaatatt tcaaactgca ggtatgcgca gacaccagca 421 aacatgttct atatagttgc atgtgacaac agagatcaac gacgagaccc tccacagtat 481 ccggtggttc cagttcacct ggatagaatc atctaagctc ctgtatcagc actcctcatc 541 atcactcatc tgccaagctc ctcaatcata gccaagatcc catctctcca tatactttgg 601 gtatcagcat ctgtcctcat cagtctccat accccttcag ctttcctgag ctgaagtgcc 661 ttgtgaaccc tgcaataaac tgctttgcaa attc 1 ctgcaggcag catatagttt tcatccagag tttggatcta accagcaaaa ctctgtctta

61 cacaggatga cttggaatta gagtccttat agcagaaaga gcagcagggc tgtccttggg

121 tatccgttgc tcagccaagt catcaaataa aaaggatgat tgcacaagtg gactatgtac

181 caatctgtgg gtttctgcat ggccaagagc cagaccctcc ctctgggctc tgctggccca

241 acccaccaag ggatgcttta tttaaacagt tccaagtagg ggagaccagc tgcccctgaa

301 ccccagaaca accagctgga tcagttctca caggagctac agcgcggaga ctgggtaagt

361 caacgatccc cagagctggg acagaagggg cagcaatggg gcagcaactg agggagaaga

421 gagctgacgt tagtgcttag gagacgttgc acactttgca gacaggaagt aaaggaaatg

481 ggaccccaga gtggccgcag aggggcctgt ggggtaagac actacagtgt gtgtcataac

541 caagacccga tcagggagta gttacttctc ttcttttctt acaggaaaca tggttccaaa

601 actgttcact tcccaaattt gtctgcttct tctgttgggg cttctggctg tggagggctc

661 actccatgtc aaacctccac agtttacctg ggctcaatgg tttgaaaccc agcacatcaa

721 tatgacctcc cagcaatgca ccaatgcaat gcaggtcatt aacaattatc aacggcgatg

781 caaaaaccaa aatactttcc ttcttacaac ttttgctaac gtagttaatg tttgtggtaa

841 cccaaatatg acctgtccta gtaacaaaac tcgcaaaaat tgtcaccaca gtggaagcca

901 ggtgccttta atccactgta acctcacaac tccaagtcca cagaatattt caaactgcag

961 gtatgcgcag acaccagcaa acatgttcta tatagttgca tgtgacaaca gagatcaacg

1021 acgagaccct ccacagtatc cggtggttcc agttcacctg gatagaatca tctaagctcc

1081 tgtatcagca ctcctcatca tcactcatct gccaagctcc tcaatcatag ccaagatccc

1141 atctctccat atactttggg tatcagcatc tgtcctcatc agtctccata ccccttcagc

1201 tttcctgagc tgaagtgcct tgtgaaccct gcaataaact gctttgcaaa ttcatctgaa

1261 agtgtctgtg tgtcttcatt agccgctctg ctgtcattta gtgacaatct actctagaga

1321 tttttcttcc tctaacctga gacttccggg aaacagagag atttgaagat aagagacgct

1381 ttctgtcatg aaacagcaca gtcttatccc tctccctgct ttaggctgag aagctgaggt

1441 ctcaaccgat atctagcaac tgtcgaagac tcttgctttg atcaagctt

1 gctgcccctg aaccccagaa caaccagctg gatcagttct cacaggagct acaggccgga

61 gactgggaaa catggttcca aaactgttca cttcccaaat ttgtctgctt cttctgttgg 121 ggcttctggc tgtggagggc tcactccatg tcaaacctcc acagtttacc tgggctcaat 181 ggtttgaaac ccagcacatc aatatgacct cccagcaatg caccaatgca atgcaggtca 241 ttaacaatta tcaacggcga tgcaaaaacc aaaatacttt ccttcttaca acttttgcta 301 acgtagttaa tgtttgtggt aacccaaata tgacctgtcc tagtaacaaa actcgcaaaa 361 attgtcacca cagtggaagc caggtgcctt taatccactg taacctcaca actccaagtc 421 cacagaatat ttcaaactgc aggtatgcgc agacaccagc aaacatgttc tatatagttg 481 catgtgacaa cagagatcaa cgacgagacc ctccacagta tccggtggtt ccagttcacc 541 tggatagaat catctaagct cctgtatcag cactcctcat catcactcat ctgccaagct 601 cctcaatcat agccaagatc ccatctctcc atatactttg ggtatcagca tctgtcctca 661 tcagtctcca taccccttca gctttcctga gctgaagtgc cttgtgaacc ctgcaataaa 721 ctgctttgca aattc

(2) INFORMATION FOR SEQ ID NO: 53: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 391 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 53:

1 ccatggagga aggtcaatat tcaggtagga ggactctctg gttctaacgt tggcagaagc

61 aatgaccctt agctactcct ttcacccaga agagaagcgg ggcttcccag tccctctctg

121 ggaaagaggg tgaatttcta agaaagggac tggtgtgagt aaggaggtga ggccgcactg

181 actttcctgg cacagagcca ggaaggagtg gaaaattgag ggcccctcct ttttctgatt

241 caacaccctc ctgacaaaaa aagaaaaaga aaaaaaaaaa cggcttcagc tagggagcgg EPI-109 1209

301 ggacgcaata gagtcagagg ccaaatagaa caggaacttg gaac ϊaαcaσ aatttagcat 361 aatgaatcct ccaagccagg gtgagtgcag a

(2) INFORMATION FOR SEQ ID NO: 54: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3108 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xι)SEQUENCE DESCRIPTION: SEQ ID NO:54: 1 aagcttggga ataagtccag ctgggccatg ttgtgaggac atggggatga agtcttagtt

61 ccaggatggg gctgggatgg agtttggtgt ttcttttctg tttttctttc ttttttcttt

121 tctttttttt ttttgtgaga cagagtttag cttttgttgc ccaggctgga atgcaatggc

181 ggatctcggc tcaccgcaac ctctgcctcc cggattcaag cgattctcct gcctcagcct

241 cccgagtagc taggattaca ggtgcccacc accatgccca gctaattttt tttttttttt

301 tttttttttg tattttcagt agatacaggg tttcaccatg ttggccttga actcctgacc

361 tcagatgatc cacctgcctc ggcctcccaa agtgctggga ttacaggcgc tgacgatgtg

421 cccggtctct ctctctctct ttctctctct ctttctttca tctcactgtg ttgccccagg

481 ctgatcttga actcctgggc tcaagtgatc cactcacctc tgcctcccca gtagctggga

541 tcacaggcat gcaccaccat gccctgctag tttttatagt ttttgtagag acaacggctt

601 gctatgttgt ccaggctggt cttgaactcc caggcttaag tgatcctccc acctcagcct

661 cccaaagtgc tgggattaca ggcgtgaacg tccgtgccag ccaaactgtc catatttgac

721 ctgaatatta tctcacgtat ctttctttcc ccccgcttcc ctccttccct cctactcctc

781 cttctccctc tccttccttc tgtctttttt ttccccttcc tctgcctctc tctcctcttc

841 ccttttttct tgctgggact caaacctggg acatttgacc tgggagccta tttgctcaat

901 catcaagaga cataatctca tggtggggtg tctgctggta agtgccgggt ggcaggatcc

961 caactccagg ccgtccttct aacccaagag gccctgcctc tgcctagagc cttccgtggc

1021 tccccagggc cctctgtgat cggccatagt ggtatgattc agtgtgcagt aacagtggtt

1081 cacatcttga cgctaccact cacctccttc agccctgtgg gaacttgctg cttaacatct

1141 ctagttctca cccaattctc ttacctgaga aatggagata ataataacac ggacttcacc

1201 cgggtgtggg gagcaccagg agaggccatg cgtgtaatgt tatccgggtg gcaagcccat

1261 atttaggtct atgaaaatag aagctgtcag tggctctact ttcagaagaa agtgtctctc

1321 ttcctgctta aacctctgtc tctgacggtc cctgccaatc gctctggtcg accccaacac

1381 actaggagga cagacacagg ctccaaactc cactaagtga gtacgtatct ggtgtgttgg

1441 gggttggccc atgggcagtg gagatcaaag cgcccttgga agaaacgacc ttgggctgag

1501 cctcaaggga tgaccagcag gaggtcacaa ccagagaagg gaggtggtgg gtggtgaggg

1561 ggcgggggtg ggggccgcag tgtggacaga atctcgaggc attcgagtcc ctgatttggg

1621 gaagtgaaag caggccatct ggtctgagat gagcttggtg agtgcgctgg gccgatcata

1681 gagggccctg gggagccatg gaagactcta ggcagaggca ggacctcttg ggttagaagg

1741 acggcctgga gttgggatcc tgccacccag cacttaccag tagacacccc accatgagat

1801 tatgtctcca gatgattgag caaatgggct cccagctcaa gggtcccggg tttgagtcca

1861 gtcccaccac tgcgtgatgg ggacaaatga cttaccctct tggaacctca gttccactga

1921 gagaggcccc acagaatgag gacagtcccc cagcatcctg ccagtaggtt tactgagcac

1981 ctactgtgtg ctggtgcttt gaatactccc aatttacaga tgagcaaact gagctgctca

2041 tccagggaga agccaggact cggactcagg tctgtccagc tgcctccctg gacagttcca

2101 gtcccaggat ggtctctggg ttcctctcac aatgtcaaaa gggccagctt gagctgccgc

2161 taatcagagc ctggccgcgc cacaccccac ctccctgagg ctccgagaga agggacttac

2221 ctatagtcaa gcagcgaaag aaggtagccc gtgacctcca ggcctgaagg accccaagtc

2281 ccatgctcct cagcacatag tagatgcttt aaagtcagag gacttggtcg ggcgcaggca

2341 cgcctgtaat cctagcactt tgggaggctg aggagggcag atcacctgtg gtcaggagtt

2401 cgagaccagc ctgatcaata tggtgaaacc ctgtctctac taaaatacaa aaattagcca

2461 ggtgtggtgg tgggtgcctg tagtcccagc tacttgggag gctaagacag gagaatcgct

2521 tgaacccggg aggtggaggt tgcagtgagc caagatggtg ccattgcact ctagcctggg

2581 tgacagagcg agactccatc tcaaaaaata aaaaaatagg ccatgcacag gctcacgcct

2641 gtaatcccag cactttggga ggccgaggcg ggcggatcat gaggtcagga gtttgagact

2701 agcctggcca acatagtgaa aacccgtctc tactaaaaat acaaaaatta tctggtcatg

2761 gtggcacgtg actatagtcc cagctactcg ggaggctgag gcgggagaat cgcttgaacc

2821 caggaggtgg aggtggcagt gagccgagat cgtgcccctg cactccagcc tgggcaacag

2881 agcgagactc catttcaata aataaataaa taaataaagt cagagcactt tacagatgcc

2941 ctggggacat tggcagagga gaaggctgag gcctgggtta tgggctctta gcatttctca

3001 gtgggacgtg gcacagagta gatgtttcat aaatgtttag aatctgaaga cccactgtgc

3061 gcagcccggc accaaaaacc tcaggtatgc tgtgatctca ttggatcc

(2) INFORMATION FOR SEQ ID NO: 55: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1503 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 55: 1 ctcctgctta aacctctgtc tctgacggtc cctgccaatc gctctggtcg accccaacac

61 actaggagga cagacacagg ctccaaactc cactaagtga ccagagctgt gattgtgccc 121 gctgagtgga ctgcgttgtc agggagtgag tgctccatca tcgggagaat ccaagcagga 181 ccgccatgga ggaaggtcaa tattcagaga tcgaggagct tcccaggagg cggtgttgca 241 ggcgtgggac tcagatcgtg ctgctggggc tggtgaccgc cgctctgtgg gctgggctgc EPI-109 1210

301 tgactctgct tctcctgtgg cactgggaca ccacacagag tctaaaacag ctggaagaga

361 gggctgcccg gaacgtctct caagtttcca agaacttgga aagccaccac ggtgaccaga

421 tggcgcagaa atcccagtcc acgcagattt cacaggaact ggaggaactt cgagctgaac

481 agcagagatt gaaatctcag gacttggagc tgtcctggaa cctgaacggg cttcaagcag

541 atctgagcag cttcaagtcc caggaattga acgagaggaa cgaagcttca gatttgctgg

601 aaagactccg ggaggaggtg acaaagctaa ggatggagtt gcaggtgtcc agcggctttg

661 tgtgcaacac gtgccctgaa aagtggatca atttccaacg gaagtgctac tacttcggca

721 agggcaccaa gcagtgggtc cacgcccggt atgcctgtga cgacatggaa gggcagctgg

781 tcagcatcca cagcccggag gagcaggact tcctgaccaa gcatgccagc cacaccggct

841 cctggattgg ccttcggaac ttggacctga agggagagtt tatctgggtg gatgggagcc

901 atgtggacta cagcaactgg gctccagggg agcccaccag ccggagccag ggcgaggact

961 gcgtgatgat gcggggctcc ggtcgctgga acgacgcctt ctgcgaccgt aagctgggcg

1021 cctgggtgtg cgaccggctg gccacatgca cgccgccagc cagcgaaggt tccgcggagt

1081 ccatgggacc tgattcaaga ccagaccctg acggccgcct gcccaccccc tctgcccctc

1141 tccactcttg agcatggata cagccaggcc cagagcaaga ccctgaagac ccccaaccac

1201 ggcctaaaag cctctttgtg gctgaaaggt ccctgtgaca ttttctgcca cccaaacgga

1261 ggcagctgac acatctcccg ctcctctatg gcccctgcct tcccaggagt acaccccaac

1321 agcaccctct ccagatggga gtgcccccaa cagcaccctc tccagatgag agtacacccc

1381 aacagcaccc tctccagatg cagccccatc tcctcagcac cccaggacct gagtatcccc

1441 agctcaggtg gtgagtcctc ctgtccagcc tgcatcaata aaatggggca gtgatggcct

1501 ccc

(2) INFORMATION FOR SEQ ID NO:56: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1530 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 56: 1 agtggctcta ctttcagaag aaagtgtctc tcttcctgct taaacctctg tctctgacgg

61 tccctgccaa tcgctctggt cgaccccaac acactaggag gacagacaca ggctccaaac

121 tccactaacc agagctgtga ttgtgcccgc tgagtggact gcgttgtcag ggagtgagtg

181 ctccatcatc gggagaatcc aagcaggacc gccatggagg aaggtcaata ttcagagatc

241 gaggagcttc ccaggaggcg gtgttgcagg cgtgggactc agatcgtgct gctggggctg

301 gtgaccgccg ctctgtgggc tgggctgctg actctgcttc tcctgtggca ctgggacacc

361 acacagagtc taaaacagct ggaagagagg gctgcccgga acgtctctca agtttccaag

421 aacttggaaa gccaccacgg tgaccagatg gcgcagaaat cccagtccac gcagatttca

481 caggaactgg aggaacttcg agctgaacag cagagattga aatctcagga cttggagctg

541 tcctggaacc tgaacgggct tcaagcagat ctgagcagct tcaagtccca ggaattgaac

601 gagaggaacg aagcttcaga tttgctggaa agactccggg aggaggtgac aaagctaagg

661 atggagttgc aggtgtccag cggctttgtg tgcaacacgt gccctgaaaa gtggatcaat

721 ttccaacgga agtgctacta cttcggcaag ggcaccaagc agtgggtcca cgcccggtat

781 gcctgtgacg acatggaagg gcagctggtc agcatccaca gcccggagga gcaggacttc

841 ctgaccaagc atgccagcca caccggctcc tggattggcc ttcggaactt ggacctgaag

901 ggagagttta tctgggtgga tgggagccat gtggactaca gcaactgggc tccaggggag

961 cccaccagcc ggagccaggg cgaggactgc gtgatgatgc ggggctccgg tcgctggaac

1021 gacgccttct gcgaccgtaa gctgggcgcc tgggtgtgcg accggctggc cacatgcacg

1081 ccgccagcca gcgaaggttc cgcggagtcc atgggacctg attcaagacc agaccctgac

1141 ggccgcctgc ccaccccctc tgcccctctc cactcttgag catggataca gccaggccca

1201 gagcaagacc ctgaagaccc ccaaccacgg cctaaaagcc tctttgtggc tgaaaggtcc

1261 ctgtgacatt ttctgccacc caaacggagg cagctgacac atctcccgct cctctatggc

1321 ccctgccttc ccaggagtac accccaacag caccctctcc agatgggagt gcccccaaca

1381 gcaccctctc cagatgagag tacaccccaa cagcaccctc tccagatgca gccccatctc

1441 ctcagcaccc caggacctga gtatccccag ctcaggtggt gagtcctcct gtccagcctg

1501 catcaataaa atggggcagt gatggcctcc

(2) INFORMATION FOR SEQ ID NO: 57: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 5533 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 57:

1 ccatggagga aggtcaatat tcaggtagga ggactctctg gttctaacgt tggcagaagc

61 aatgaccctt agctactcct ttcacccaga agagaagcgg ggcttcccag tccctctctg

121 ggaaagaggg tgaatttcta agaaagggac tggtgtgagt aaggaggtga ggccgcactg

181 actttcctgg cacagagcca ggaaggagtg gaaaattgag ggcccctcct ttttctgatt

241 caacaccctc ctgacaaaaa aagaaaaaga aaaaaaaaaa cggcttcagc tagggagcgg

301 ggacgcaata gagtcagagg ccaaatagaa caggaacttg gaacaagcag aatttagcat 361 aatgaatcct ccaagccagg gtgagtgcag a aagcttggga ataagtccag ctgggccatg ttgtgaggac atggggatga agtcttagtt

61 ccaggatggg gctgggatgg agtttggtgt ttcttttctg tttttctttc ttttttcttt

121 tctttttttt ttttgtgaga cagagtttag cttttgttgc ccaggctgga atgcaatggc

181 ggatctcggc tcaccgcaac ctctgcctcc cggattcaag cgattctcct gcctcagcct

241 cccgagtagc taggattaca ggtgcccacc accatgccca gctaattttt tttttttttt EPI-109 1211

301 tttttttttg tattttcagt agatacaggg tttcaccatg ttggccttga actcctgacc

361 tcagatgatc cacctgcctc ggcctcccaa agtgctggga ttacaggcgc tgacgatgtg

421 cccggtctct ctctctctct ttctctctct ctttctttca tctcactgtg ttgccccagg

481 ctgatcttga actcctgggc tcaagtgatc cactcacctc tgcctcccca gtagctggga

541 tcacaggcat gcaccaccat gccctgctag tttttatagt ttttgtagag acaacggctt

601 gctatgttgt ccaggctggt cttgaactcc caggcttaag tgatcctccc acctcagcct

661 cccaaagtgc tgggattaca ggcgtgaacg tccgtgccag ccaaactgtc catatttgac

721 ctgaatatta tctcacgtat ctttctttcc ccccgcttcc ctccttccct cctactcctc

781 cttctccctc tccttccttc tgtctttttt ttccccttcc tctgcctctc tctcctcttc

841 ccttttttct tgctgggact caaacctggg acatttgacc tgggagccta tttgctcaat

901 catcaagaga cataatctca tggtggggtg tctgctggta agtgccgggt ggcaggatcc

961 caactccagg ccgtccttct aacccaagag gccctgcctc tgcctagagc cttccgtggc

1021 tccccagggc cctctgtgat cggccatagt ggtatgattc agtgtgcagt aacagtggtt

1081 cacatcttga cgctaccact cacctccttc agccctgtgg gaacttgctg cttaacatct

1141 ctagttctca cccaattctc ttacctgaga aatggagata ataataacac ggacttcacc

1201 cgggtgtggg gagcaccagg agaggccatg cgtgtaatgt tatccgggtg gcaagcccat

1261 atttaggtct atgaaaatag aagctgtcag tggctctact ttcagaagaa agtgtctctc

1321 ttcctgctta aacctctgtc tctgacggtc cctgccaatc gctctggtcg accccaacac

1381 actaggagga cagacacagg ctccaaactc cactaagtga gtacgtatct ggtgtgttgg

1441 gggttggccc atgggcagtg gagatcaaag cgcccttgga agaaacgacc ttgggctgag

1501 cctcaaggga tgaccagcag gaggtcacaa ccagagaagg gaggtggtgg gtggtgaggg

1561 ggcgggggtg ggggccgcag tgtggacaga atctcgaggc attcgagtcc ctgatttggg

1621 gaagtgaaag caggccatct ggtctgagat gagcttggtg agtgcgctgg gccgatcata

1681 gagggccctg gggagccatg gaagactcta ggcagaggca ggacctcttg ggttagaagg

1741 acggcctgga gttgggatcc tgccacccag cacttaccag tagacacccc accatgagat

1801 tatgtctcca gatgattgag caaatgggct cccagctcaa gggtcccggg tttgagtcca

1861 gtcccaccac tgcgtgatgg ggacaaatga cttaccctct tggaacctca gttccactga

1921 gagaggcccc acagaatgag gacagtcccc cagcatcctg ccagtaggtt tactgagcac

1981 ctactgtgtg ctggtgcttt gaatactccc aatttacaga tgagcaaact gagctgctca

2041 tccagggaga agccaggact cggactcagg tctgtccagc tgcctccctg gacagttcca

2101 gtcccaggat ggtctctggg ttcctctcac aatgtcaaaa gggccagctt gagctgccgc

2161 taatcagagc ctggccgcgc cacaccccac ctccctgagg ctccgagaga agggacttac

2221 ctatagtcaa gcagcgaaag aaggtagccc gtgacctcca ggcctgaagg accccaagtc

2281 ccatgctcct cagcacatag tagatgcttt aaagtcagag gacttggtcg ggcgcaggca

2341 cgcctgtaat cctagcactt tgggaggctg aggagggcag atcacctgtg gtcaggagtt

2401 cgagaccagc ctgatcaata tggtgaaacc ctgtctctac taaaatacaa aaattagcca

2461 ggtgtggtgg tgggtgcctg tagtcccagc tacttgggag gctaagacag gagaatcgct

2521 tgaacccggg aggtggaggt tgcagtgagc caagatggtg ccattgcact ctagcctggg

2581 tgacagagcg agactccatc tcaaaaaata aaaaaatagg ccatgcacag gctcacgcct

2641 gtaatcccag cactttggga ggccgaggcg ggcggatcat gaggtcagga gtttgagact

2701 agcctggcca acatagtgaa aacccgtctc tactaaaaat acaaaaatta tctggtcatg

2761 gtggcacgtg actatagtcc cagctactcg ggaggctgag gcgggagaat cgcttgaacc

2821 caggaggtgg aggtggcagt gagccgagat cgtgcccctg cactccagcc tgggcaacag

2881 agcgagactc catttcaata aataaataaa taaataaagt cagagcactt tacagatgcc

2941 ctggggacat tggcagagga gaaggctgag gcctgggtta tgggctctta gcatttctca

3001 gtgggacgtg gcacagagta gatgtttcat aaatgtttag aatctgaaga cccactgtgc

3061 gcagcccggc accaaaaacc tcaggtatgc tgtgatctca ttggatcc

1 ctcctgctta aacctctgtc tctgacggtc cctgccaatc gctctggtcg accccaacac

61 actaggagga cagacacagg ctccaaactc cactaagtga ccagagctgt gattgtgccc

121 gctgagtgga ctgcgttgtc agggagtgag tgctccatca tcgggagaat ccaagcagga

181 ccgccatgga ggaaggtcaa tattcagaga tcgaggagct tcccaggagg cggtgttgca

241 ggcgtgggac tcagatcgtg ctgctggggc tggtgaccgc cgctctgtgg gctgggctgc

301 tgactctgct tctcctgtgg cactgggaca ccacacagag tctaaaacag ctggaagaga

361 gggctgcccg gaacgtctct caagtttcca agaacttgga aagccaccac ggtgaccaga

421 tggcgcagaa atcccagtcc acgcagattt cacaggaact ggaggaactt cgagctgaac

481 agcagagatt gaaatctcag gacttggagc tgtcctggaa cctgaacggg cttcaagcag

541 atctgagcag cttcaagtcc caggaattga acgagaggaa cgaagcttca gatttgctgg

601 aaagactccg ggaggaggtg acaaagctaa ggatggagtt gcaggtgtcc agcggctttg

661 tgtgcaacac gtgccctgaa aagtggatca atttccaacg gaagtgctac tacttcggca

721 agggcaccaa gcagtgggtc cacgcccggt atgcctgtga cgacatggaa gggcagctgg

781 tcagcatcca cagcccggag gagcaggact tcctgaccaa gcatgccagc cacaccggct

841 cctggattgg ccttcggaac ttggacctga agggagagtt tatctgggtg gatgggagcc

901 atgtggacta cagcaactgg gctccagggg agcccaccag ccggagccag ggcgaggact

961 gcgtgatgat gcggggctcc ggtcgctgga acgacgcctt ctgcgaccgt aagctgggcg

1021 cctgggtgtg cgaccggctg gccacatgca cgccgccagc cagcgaaggt tccgcggagt

1081 ccatgggacc tgattcaaga ccagaccctg acggccgcct gcccaccccc tctgcccctc

1141 tccactcttg agcatggata cagccaggcc cagagcaaga ccctgaagac ccccaaccac

1201 ggcctaaaag cctctttgtg gctgaaaggt ccctgtgaca ttttctgcca cccaaacgga

1261 ggcagctgac acatctcccg ctcctctatg gcccctgcct tcccaggagt acaccccaac

1321 agcaccctct ccagatggga gtgcccccaa cagcaccctc tccagatgag agtacacccc

1381 aacagcaccc tctccagatg cagccccatc tcctcagcac cccaggacct gagtatcccc

1441 agctcaggtg gtgagtcctc ctgtccagcc tgcatcaata aaatggggca gtgatggcct

1501 ccc agtggctcta ctttcagaag aaagtgtctc tcttcctgct taaacctctg tctctgacgg

61 tccctgccaa tcgctctggt cgaccccaac acactaggag gacagacaca ggctccaaac EPI-109 1212

121 tccactaacc agagctgtga ttαtgcccgc tgagtggact gcαttαtcag ggagtgagtg

181 ctccatcatc gggagaatcc aagcaggacc gccatggagg aaggtcaata ttcagagatc

241 gaggagcttc ccaggaggcg gtgttgcagg cgtgggactc agatcgtgct gctggggctg

301 gtgaccgccg ctctgtgggc tgggctgctg actctgcttc tcctgtggca ctgggacacc

361 acacagagtc taaaacagct ggaagagagg gctgcccgga acgtctctca agtttccaag

421 aacttggaaa gccaccacgg tgaccagatg gcgcagaaat cccagtccac gcagatttca

481 caggaactgg aggaacttcg agctgaacag cagagattga aatctcagga cttggagctg

541 tcctggaacc tgaacgggct tcaagcagat ctgagcagct tcaagtccca ggaattgaac

601 gagaggaacg aagcttcaga tttgctggaa agactccggg aggaggtgac aaagctaagg

661 atggagttgc aggtgtccag cggctttgtg tgcaacacgt gccctgaaaa gtggatcaat

721 ttccaacgga agtgctacta cttcggcaag ggcaccaagc agtgggtcca cgcccggtat

781 gcctgtgacg acatggaagg gcagctggtc agcatccaca gcccggagga gcaggacttc

841 ctgaccaagc atgccagcca caccggctcc tggattggcc ttcggaactt ggacctgaag

901 ggagagttta tctgggtgga tgggagccat gtggactaca gcaactgggc tccaggggag

961 cccaccagcc ggagccaggg cgaggactgc gtgatgatgc ggggctccgg tcgctggaac

1021 gacgccttct gcgaccgtaa gctgggcgcc tgggtgtgcg accggctggc cacatgcacg

1081 ccgccagcca gcgaaggttc cgcggagtcc atgggacctg attcaagacc agaccctgac

1141 ggccgcctgc ccaccccctc tgcccctctc cactcttgag catggataca gccaggccca

1201 gagcaagacc ctgaagaccc ccaaccacgg cctaaaagcc tctttgtggc tgaaaggtcc

1261 ctgtgacatt ttctgccacc caaacggagg cagctgacac atctcccgct cctctatggc

1321 ccctgccttc ccaggagtac accccaacag caccctctcc agatgggagt gcccccaaca

1381 gcaccctctc cagatgagag tacaccccaa cagcaccctc tccagatgca gccccatctc

1441 ctcagcaccc caggacctga gtatccccag ctcaggtggt gagtcctcct gtccagcctg

1501 catcaataaa atggggcagt gatggcctcc

(2) INFORMATION FOR SEQ ID NO: 58: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 825 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 58: 1 gtaagtatct tccctctgtg gctaggaaga caaggaatac atttttaaat gtctcctaaa

61 gcaaggacct gaaaccagct ctatgggatt attcttgttc ctctttggtc aatgcagaga 121 catgggaaga accaccaaag gtcatgaggg tctcttccag ggatccctgg acattgcctt 181 tcccagtggt gtgacaagag ttagaggtgg cctaccttgc ctcctgtcct aggaggcgac 241 agtaggagag ccttcggttt tctcatcctc ttacttgtat gttgaacttt acttaatgca 301 ggctatatcc aaaatacagt gtgaattagg ctagaataga aatgctttct attctacctt 361 cagaaaagga aaagggtagg gtaggggaaa tcatgggaga gattaaaggc agagaggaaa 421 cccagatggg actgtttaat ccccaagcaa gaaaccacta ggaaagagag ataccttccc 481 tctaactttt gtattcggtg cactgacatt gctctctgtg ctggtgggaa attgatttct 541 gtgccaggat gttctaggct gaggccaaga gggtgctggc cctttaccca gtggaagaaa 601 aaggcaaggg tgaggctttg tagactttcc cattcggagg taatgatgcc tccttcagcc 661 ccacttcttc aaactgactc cacctgctcc catctccaca cccctccgtt tctcatttag 721 ccaaagcaca tcatccttgc agcccaccac tcagcttggc caggtgcgag acatctttcc 781 ccacttcata cctcccctcc ggccaggtga tgtttgcctc ctcag

(2) INFORMATION FOR SEQ ID NO: 59: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32351 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 59: gatcacctga agtcaggagt tcgagaccag cctgaccaac atggagaaac cccgtctcta 61 ctaaaaatac aaaattagtt gggcatggtc gtgcatgcct gtaatcccag ctactcagga 121 ggctgaggca ggagtatcac ttgaacccag gagacggagg ttgcggtgag ccaagaacat 181 gccattgcac tccagccttg gcaacaagag caaaactccg tctcaaagaa aaaaaaaatt 241 tttttttgtc aacccatgtg ggtatgaaat tgtttctcat tatttgcatt tcactaatta 301 ctagtgaggt caaacatttt ttccctcatt tcttatccat taaagtttat tctgtgaatt 361 gccagttcat ggccattttg ggggtgtagt ttttcttact gatttattga agtttaatgt 421 ttttctggaa actaatattt tgctagttgt gtgaattgta aatatcttct cccactgtat 481 ttttttaaaa actttttatt gtctgaatta gcacatattt agtgaatgcc tctatgtgca 541 attctttttt tttttttttt tttttttttg agatggagtt tcgctcttgt ttcccagact 601 ggagtgcagt ggcatgatct aagctcactg caaccttcac ctcccgggtt caagtgattc 661 tcctgcctca ggcctcctga gtagctggga ttacaggtgc ccgctaccat gaccagctaa

721 ttttttgtat ttttagtaga gacggggttt catcatgttg gccaggttgg tctcgaactc

781 ctgacctcag gtgatccacc cgcctcggcc ttccaaagtg tagggattac aggcatgagc

841 cagtgagctc agcctctatg tgcaattctt aatgtcaagc tgagggagaa gtctaagaag

901 ttttatataa gtctgacacc cagggtgcct gtaattaaag gtggaatgaa attttaattt

961 gcgagttgat ccttctgttt tttagttcag tacttcctcc tttttagaat gtatgctttc

1021 cagataatta gtgagataaa gatttgattt tcacttttag catttctaaa agctgtaata

1081 tgctacctaa cttgttttta attcttgctc taacttctga tattttatag ttgtgtattt

1141 tgaattatat tttaaaggat taagtggatt attgcacatg atatttagta aagtgtttgg

1201 gagcatttag cacagcctcc aaaaattaga attccactag ccccctgatc ctacatatct EPI-109 1213

1261 ggcatcttaa gagtcaataa tagcaaagtt gagagaggca gcttggtgtg gtggaaagaa 1321 catgggtatt ggatccgata gccttaggtt caaatcctgg cttcttcagt aattatcttc 1381 tgtaatttta gccaagtgtt taatttcctt gagactcagt ttctcgaaga tgaagtagaa 1441 aatggctttc accaggttgt tgtaaagact gaatcaaata gtgtgcatga aaattgcaag 1501 gcatagtgct caggacatag ttaacattct taaatatatg ttgaggaatg gtgtgcacct 1561 gaaaattcct ataaaagctg caaatataca tgccttttga tccagctgtt ccacttcagg 1621 atatccttac tcatgtgtgc aaagcaattt tttgtagaaa tgtttgtaat agcaaaagac 1681 tggaaacaac tgaaatgtac actgctaggg aactgattac tctctggtat gtccacgcaa 1741 tgcagctcta tgaaaaaaag gagtacgtgt caagatatat taacaaataa agtacagaat 1801 attgtactgt acttatccct tttgtgttta acaaaagaaa gaaaaggaga aaaattagaa 1861 tatagtatat atttgccttt atgtgcaaaa aaaggaaatc actttttgtt ttttttgaga 1921 cagggtctca ttctgtcacc caggctgggg tgcagtggcg ctatcacggc tcactgcaac 1981 ctcaacctcc caggctcaag cgatcctccc gccacagcct cccaagtagc tgggactaca 2041 ggcacacgcg ccatgcccag ctaatttatt tatttatttt tggtagagat ggggtttcgc 2101 gatgttaccc aggctggtct caaactcctg agttcaggtg atccacctgt cttggcctcc 2161 caaagtgctc tgggattaca ggcatgagcc actgtgcctg acctcttttc ttcttgatgt 2221 gaaattcttc atagattaga caaatttgcc cattgtgcaa atatgttgca aatatatttt 2281 ctcagtttgt catttatctt gatttttctt atggttttaa aaaaatgtga ttggatttat 2341 ggtttctggc attgaaccat agttataaat gtattcttta ctctgaggtt gtccagggaa 2401 tcttctaatt ttcttaattt aattttcatc ttttaaaaac agctctattg atgcataatt 2461 gatatacaaa aatagcatat atttactact atttgatgag tttggacatg tgtacacacc 2521 catgaagcca tcagttaacc tgatggtggt gatggtttcc tgtaatttta tgcttccatt 2581 tttcacattt agatctgact tttctggaat ttatctaagt gcacgatgtg aaagatagat 2641 acagcttatt tttctttcca gatggctata ccttgttcta ggacaattta ttaaatagtc 2701 catctttttc tttctgatct gagatgctat ctttattata tgctaaattt ctgtacatgt 2761 ttaaatttat ttgctccttt tgtttgtctc tttgtacacc agtatctacc tcattgttct 2821 aattattcga gcttcaggat acattttaat acttctgggt aggaacaσaa ccttctcgtt 2881 actcttacaa aattttcttc tttattctgg tttatttttc ctaagaactt taaaagttgg 2941 cactgaattc caaaatagaa cacccaaaaa cctgttgatt tttccactgg gattatgtta 3001 aattttcggg ttaacttagg ggaaaaccat tatttcatga tgttaaatct tactccatga 3061 gagagcatgg tacgtctttt catctgtaca ggtctttttt tatattgttc agtagcaatt 3121 taaaaaaatc atccactatg ttcaatgaaa taaaaggcca gatttaaaaa tttggcaagg 3181 agttgaaaac tataaaaagg aaccaaataa aaattctttt tttgccccca taaggcagaa 3241 gaaatacaaa ttctacaact gaaaaaatat aatatctgat attaagaaat caataaatgg 3301 tttattatat tagctacatt tgaagagaca actaaaaaag aaaaatattt tcaaaccaac 3361 tcagaaacaa gaagatggaa aataaagaat acaatgctat ttatatttat atataatagt 3421 atatataata cacaagttta acataggact gcatttgcag aatagaagag agataatggg 3481 gagatagcaa cacttggaga aaaaataacg aacacttttt tatttaaagt gcctaacttg 3541 gctgggtgtg gtggctgaca cctgtaatcc caacactttg ggaggctgag atgggtggat 3601 catttgagcc caggagttca agaccaactt gggtaacatg gcgaaacccc atctctacag 3661 aaaaactcca agaaataaaa aacaataatc atctgagtgt ggtagcacat gcctgcgtcc 3721 ttgctactca ggaggtgggg gtggcagaat taccagggcc tggaagtcaa ggctgcaatg 3781 agctgtgatc gcatcactat acttcagcct ggttgacgag tgagaccctg tctcaacaaa 3841 taaaaataaa aataaaaata aaaatgccta acttggtgct tggcactttc taaaattgac 3901 acataatatt tgtacctgtt tatggagtat atgtgatatt ttgatacatg catacaatgt 3961 gtgtaatgat caaatcagga tatttaagat atccatcatc tcaaacattt ttctttgtgt 4021 tcagaacatt ccaaatctag ctattttgaa atatacaata aattattaac tatagtcatc 4081 ctaatgtgct attgaatatt attgaattcc atctaattat atgtttgtac caattaacca 4141 atctctactt attcctcacc cccagctccc accaaccctt tccagtctct ggtaactatc 4201 attttattct ctacctccat gagatcaaat tttttacctc ccatatcgtt gtcaatatta 4261 ttatttttcc caccctggct cctaatgaag gatttattga caatatcact ggaatctaaa 4321 tcctctaggc cattttttca ccaatgccct tattttctta gggctttttt ttttcttaaa 4381 tcaacagttt taatgagata taattcccat tctataaaat ttcctcgttt gaagtgtaca 4441 gtttaatagc ttttagtata tccacagaag tgtgcaacca tcaccataat aaattttaaa 4501 acattttcag cagggcgcag tggctcacgc ctgtaatccc agctactcag gaggctgagg 4561 caggagaatt gcttgaaccc aggaggcaga ggtttcagtg agccgagatt gcaccactgc 4621 aatccagcct gggccacaga gtgagactcc atctcaaaac aaaacaaaac aaagcaaaat 4681 aaaacaaagc aaaataaaac aaaaccaaaa cccaacaatt ttgaacattt tcatcttacc 4741 accctgccaa aaatccctgt tctccttagc catcaatctt cagctcccta cccacttcta 4801 accatgaatc tattttgtag atttgtctat tctcgatatt tcatatgaat gaaataatat 4861 aatatatggt tccttgtgac tagtttcttt cacttagtat gtttccaagt tcatccatgt 4921 tttggtatgt atcagtactt cattcctttt tatcatggaa taatattctg ttgtattgat 4981 atactacgtt tcattcattc atctgaacat ttggattatt tccatttttg tctattataa 5041 taattctgct atgaacaccc atgtatacgt ttttgtgtgg acatgatttc attttccttg 5101 gatatacacc tagcagtaga attgttgagt cataaagaac tctaggttta gctttctggg 5161 gagcttccag attattttcc aaaatggctg tgccatttta cattcccacc agtaaagtat 5221 gagggttcta atttttccct gtcttcacca atacttgttg ttatctatct tttttattat 5281 agtcatcata gtctgtatga agtgatttct cactgtagtt ttttcagtag taattaaaaa 5341 atttcctacc tattttagcc taaaattact ttcctgactc tcttcaagga gcctgccaga 5401 gaattctctc tctcgtgctg tctcccttat gcctgggcat aagctctgat aatgccctgt 5461 ctgggaaaac tcttttggcc ttctcaattt ctattacatt gagagcccaa gaacccatgg 5521 tcagtaacag gccaatgaga agcctcctgc attagtctag gtgaaggata atggtggctt 5581 ggaccggaat agggtggtag tcatggaaat ggggagaatt tgacagacta gatttatttt 5641 ggaaatagaa ctgaatctga acagattgaa ttgggcaggg agcagggaaa gtgaagggga 5701 aggaagacac caggtttatg ccttcagcat ttgggtggat gaatggatgg atgaaaggat EPI-109 1214

5761 agatggatgc atggatggtg gttggatgga tgagtggttg gatgaatgga cggtcaaggg

5821 gtgaatagat gggtggatgg aaaatggaga gatgatgaac tgagatgggg aagactagaa

5881 gtggggcata tttttgggga aagacagttt tgcaatacgt taagtttgag gtgcctcaga

5941 gtcataagag aggatttgtc agaaaggcag ttggatataa gattttgaag ctcaaaagac

6001 agggagggcc tgatggtatg tttaaaccta tacggatatc acataggtaa catttcaagc

6061 ctaagaaatg ggccgggcgc agtggctcac acctgtaatc ccagcacttt ggaaggctga

6121 ggcgggtgga tcacttgagg tcaggagttc gagacaaacc cagccaacat ggtgaaaccc

6181 catctctgct aaaaacacaa aaattagtgg ggcatggtgg cacatacctg taggcccagc

6241 tactcaggag gttgaggtgg gagaattgct tgaacccggg aggcagaggt tgcagtgagc

6301 caagattgcg ccactgcact ccagcctggg cgacagagca agactccgtc taaacaaaac

6361 aaaacaaaaa aagccttaga aatgggcaat gccaccaaag cagaaagatg aaaggagggc

6421 aatgccctga ggtgtgccag cattggagga aacaaacagc cagagatgta ggaggaaagc

6481 ccagagaaac tgtgagctgc aaggatgaag tagtaacaaa taaaatgcca ccaagagaac

6541 cagaaggacg actggaaaca aataaacaag aaagactatt gcatttagca acgtgaaaac

6601 gttggattac tttttactca gaaatcaaac cccaaggata gtgtttcccc tccctacggg

6661 gtttctgcag gtccctttac acgccccctt ctacttcttt aagtgctaaa agtgattaat

6721 ttggggtgat gttttaattt ctattctttt tggcttataa ctgtgttttt tcattctttg

6781 caacaacaga tagtatgttg taatagaaaa atccattgtg gtcaatgata acttctgcct

6841 gttcctgggc acagggggca tcactattag tgcctgttcc tccctcccta ctgctgataa

6901 ggaaacaggg gcaggaataa tactaataat ttgtgctact ttttctgcat acccttggcc

6961 ttattctggt ctactgagct gggagcttgt ctgaggctgg agctctattg tctgaatcca

7021 ggggcagaaa gaactgaggg ctcttttacg gcatccacct ggaggctgcc tgcaggcttg

7081 ggttgctaag tgcactgctt aatttagaag cgccttttat cctggctctc ttgaccagtc

7141 aaagttgtgg tcgctgtttt ctacaaggac tggggaaaga aagggtggaa ttaattaaac

7201 ctggaggaag ggactttgaa gggcggagct aaggtcaaag aaagaaccct ttaaataaag

7261 ggcccacact ggctgccagg gagtgcgcag gactggcaag agggaagccg ggctgctcca

7321 cgcctttcac gccttccacc tcctgcgtgt ccatctgtga gaaggagcca gagcccaagg

7381 gagatgatgg agcctgagga gtacagagag agaggtgagc aacgggcatc cctggccctc

7441 ttccctgctg ctactcctgc aggaacggct gctggtgggt ggcccttaga ttgtggggtg

7501 acatttgatg ggagcattag aattgccttc tgagagttgg caccagcaac attttttttt

7561 ctgcgaaagg aatgtgggat cagagtgtaa aacttttctc aaccactctt tcattctccc

7621 tctcatatac ccactctcac atatgtccac actaccgtgc cttgcttttc ctccccactt

7681 tcccacaaaa ttgaggattt ggatccctga gccactagat gggaaaaggg gattgttcat

7741 attctgaaat agaaaaaaat tttctcaata ttctgtaatc actgcaaatc ctttctttct

7801 taacattcat tccttcatgt gtgaatctat cagcagtgtt ctttcattta gtcattcatt

7861 tcataaatat ttagtaggtg cctactctgt atcaggcaaa accaagtggt tatccagttc

7921 tcaggcatgg atctccctta gcaggaaagt aggtagttgc ttaaaaaaga atcttgaatg

7981 tctatttcta taatgtttta tatcctccta ctcactaatt agtgtgcgtt agcttattcc

8041 attgctttcc taaggcactg tcagctgaga gcaagttcct gtggatattt atcttctgag

8101 tggaacacaa atacatttag cactgttcct ggatcagtgg agggttaggt ctagagctct

8161 cagatctctg gtggggccct gctggagaag aaccaggatg tgagagggtt gaaggggagc

8221 agaaggaaga tagaatggtg tggaaatcta cctttgtctc ataagttttg tctggggttg

8281 gttctgttct taagaacttt gcataagctg atgcagaggg gagaaactga gtcccctctc

8341 ctaggtaaaa gcagcccagg gagtactaag gaatggatgt tgagacagac aaagagatat

8401 gtacacacac acacatgcac acacagcaac agaggcactg aagactgcaa tctgaaagaa

8461 taaataattt gcaatagttt cagagtgttc aacttgactt ttttttcctt ccttactcat

8521 atgttcattc acttgataca ttttttttta gcatctaaaa aatatcctaa gcactgaggt

8581 gttgatggag gcagcaggag ggagagaaag tcattaagat ttggtgccac atttcccagg

8641 ccagggcagg gggcttggtc tggatccatg gttgtgcttt agggattctg tgagcctcag

8701 aaattataca caaagttctg tgtatatgta agcctacagt tttaatcaga ttcttgaatt

8761 aagtcctcat atgagtccaa aaaagatgaa taataactga ttcaatgggg atggtgaaaa

8821 aatagatttt tttgtccttt atcggaactg ggcatggaat ctttctatct gtgctaacag

8881 atataactgg tgggtgtgtg tgtaacaatt tttggataca aagagctata gagtttctat

8941 tgaacctata aaatagttaa tagatgttct gtttctgaga aggaaagaaa ggtaggagag

9001 acaatcaaaa ttgaagtgga taaaggaagg ggaaagaaaa tgaaacgttt cactttggcg

9061 ctagagtttt gtgctttgga gattttcctt tttgttcatt tgctcactta gaaactccct

9121 ccatcattca ttcactccct cactcttttt ttaaattctg aagataaggt cgtgcagggg

9181 atcagatcct accctcggcc catgaatctg tctctctctt ttttttgagt ccaggctgga

9241 gtgcagtggc acgatctcgg ctcactgcaa cctccgtctc ccaggttcaa gcgattctcc

9301 tgcctcagcc tcccaagtag ctgggattac atgcgcctgc caccacgccc ggctaatttt

9361 ttgtattttt agtagagagg ggtttgacca tgttagtcag gatggtcttg atctcctgac

9421 ctcgtgatcc gcctgcctca gcctcccaaa gtgctgggat tacaggcatg agccactgtg

9481 cccggccaaa tccatctcct tctttaccaa gtctcttggc ccggacctga gagggatggg

9541 cacaaatcgg tcaggcccag tcaggggatt tcagcctgat ttctctatgt cacttctagg

9601 gagagagatg gtggattaca tctgccagta cctgagcact gtgcgggaga gacgtgtgac

9661 gccagacgtg cagcctggct acctgcgagc ccagctgcct gagagtgctc ctgaggaccc

9721 cgacagctgg gacagcatct ttggggacat tgaacgaatc atcatgcctg gggtgagaca

9781 cagtgaccac aagggcagtt ctggatttca gggcacagaa gggtgggtgg tggcctggag

9841 aaagacctgc tttgggtcag cttgggatga gaatgcatcc ttcagccact tggccaccaa

9901 caccccagcc catctgctag gcatgtggag ggcaggactt tgactggtat taggtttctt

9 61 tttctttttt tttgcccagt tgtgccatgg catgaggttt ctgatgccag ggcagggctg

10021 gccagaacac ctgcattcca gagcacagcc tggcagaagt gtggaagtct aatgggatgg

10081 gtggagaagt gaacattttg tctgagggga aaggacactg tgtatagtaa gacaggggag

10141 aggaagctgg tggtagtgcc tggccctgac gacggagcca gagactcttc tgtacagtgt

10201 ctgagaccac accaaagaga aggaaggaag tggggaacac atcctggcaa ggacacgctg EPI-109 1215

10261 gtgaccaggt tgcgttggcc caagaaactg agtgggccct ggcaacccct cctgtcccct

10321 ctgaggtctg gtgattgagc tgcttttcaa gagcaagaag ggactttccc tgaatcattg

10381 atactttcca tgatggaggg tgcagcctgg gatagtgctg gtggggccag gaagctgatg

10441 gaagctggct gatgcatggg cttgagctgg agcctgcctt gatgggtggt ggacacccct

10501 gaccactggc ggtgaggagc tctgccatgg tgctcatgct aaagtggcat cgactccctt

10561 cctgtggcgg ggctccctgc catgtgccag ctctgtgctg gccacatgac atgctatcta

10621 atttaatctt cccagtggcc ctgttttaca gatgaggaaa ctgctgatgc tcagagaagt

10681 taactgtctt gcccaaagtc acagaattag tacctggtag atccaggatt ttaccctaga

10741 ccagtcttac ttcacaggct gtgccgtttc tcctaccccc tgtcacctct actggtgggt

10801 gcctgaatgt gcctggctaa gcctgggccc ctagcattgc ctgtctggct ccacaccccc

10861 acacaagctg tgtcttccct ctccctgctt ggggcatttg tgttctgaac cacacatgtt

10921 tagaggctct tcctgaggcc agcttgaggt ttgccttcat cattcccaaa gaacttttga

10981 cttcaatgtg acaaaaaggc caggcgcggg ggctcacacc tgtaatccca gcactttggg

11041 aggccaaggc aggtggatca cctgaggtcg ggagttcaag accagcctga ccaacatgga

11101 gaaaccccgt ctctactaaa aatacaaaat tagctgggca tggtggcaca tgcctgtaat

11161 cccagctact tgggaggctg aggtaggaga atcgcttgaa cccgggaggc ggaggttgcg

11221 gtgagctgag atagcgccgt tgcactccag cctgggcaac aagagcgaaa ctccatctca

11281 aaaaaaaaaa aaagtgacaa aaatatgcct agaggcaggg gtgggaaaat attcaaactc

11341 agaaagtgat ggcaattttg actttttttt tttttttttt ttgaagcaat agagacaagg

11401 tcttgctatg ttgcccaagc tggtctccaa ctcctgggct caagtgatcc tcctgcctcg

11461 gccttccaaa gtgttgggat gagaggccta agccactacg cctggccatg agggcaattt

11521 catacaaagc cactcatctc tttgaccatt cagcctattt cacaagcatt ttttgaaaat

11581 gtcaatatca gtaaggcttt acggaggcta gatcctgata agattatctc ctggatttta

11641 ttctgtaaaa tgtaatctgc tgaggggcta actgtaatct gggagtgaga ctgaaagcaa

11701 ctgtcagaag aggtggaaat gagctgattc atttgatcaa gaggaattcc agcagttgct

11761 gtgggtatgg tcggtgaggc tcatttctgg aaagaggtct gtttgttttt gataagggct

11821 cttctggcta ttttatctta tttatcttac aagaacagac tattgtctct tgatagagct

11881 aggaggtaga agcccttctc tggggtttcc aaaatactgt cactaaggac agtgataatg

11941 atggtcaaat ctctcaactc atctctcagg ccacaccagc ctctgagagc tggcctgaaa

12001 gcagttggcc ctttgcttac tcattttgct cagtgcctca ttgaaaactg aattagtttt

12061 tctcttcctg ccaccaccta gaaaataaga gaagaagaaa aactctcttt cccctttaat

12121 tccaaccctg gttagacaat cctcatttac ttttcatgag agagagagag catccccacg

12181 ggaaaagtca ggacaccacc ctgctcgggt gtctgggctt ctgcctcatt gcggtcacct

12241 gtccctatgg ggtatgtgtg accacaggga tgtggcctct ctctgtcagc cccagttctc

12301 gcctgcaaaa cagagataat gtgtaggtcc taccccatag ggtcctgtga gaagtaagta

12361 agagaaggct tggagagcag gagatgtggt tattaccgat catgactctt acatggtgaa

12421 aattggagga agaggtttga ttctctgagt caagtcagga tatgtgatgt gtctgtcacc

12481 cacatgatta gtttaccgtt aatgttagag cttaacattt cacacatttc ttgcccacgc

12541 ctccacccac acaacaaccc taggagacag gatttatttt acgatgagaa actgaggttg

12601 agggaggtgc aggagaggct cctggtctta tggggtctgt actgtaaaca ctttttgaga

12661 cctccttttg aaaaacaaaa aagaaggagg ccggacacag tggtgcacgc ctgtaatccc

12721 agcactttgg gaggctgagg cgggtggatc atgaggtcag gagttcgaga ctagcctggc

12781 caacatagtg aaacactttc tctattaaaa atacaaaaaa ttagccaggc atggtggtgg

12841 gcacctgtaa tcccagctac ttgggaggct gaggcaggag aatctcttga acctgggagc

12901 caggggttgc actgagccaa gatggcgctg ctgcactcca gccctggtga cagtgcgaga

12961 atctgtctca aaaaaaaaaa aaaaagaatg aatctcaaaa gagacccaca caaatggtat

13021 gttggagctt aagttcatta gcttcatggt aaatctacac ggtcacacag ctggttaggg

13081 actgaggtgg gatgggaact tgtgtccttg gacttaattc ttaggctcct tatactatac

13141 acactgtcca ggacaaggtc cttgctcttg aaggactcta agtatgtgtg gacagtaaag

13201 aacaggatga tgccctaaga tgttatcaaa tgagtcctca gtagagtgaa acatctagaa

13261 ttctagagtt ctatcgctca gggaagggat cgaagggagc tgtgggagct gggggagagt

13321 tcgaggagga aatgaatatt tagtagcttt ctaagaactg gcaggttttg gaaggtcatg

13381 tctttataga gagtgccttt ctatcagggg acacagcatt gctcaaagac ataaatgcag

13441 aaaggaacag ggcatgcttc agagcagtga gatgaggaga gatgagataa tccatgaggc

13501 cgatgaacca ccagggctgc ttctgagttc tgatgggggg cccttcctgc ccactcagct

13561 cctccttaca tccggttttg attgtgggct cagggcttag cctggaggtc ggcctcccat

13621 acgcttggtc tgggctctcc tctctaccgt ctcctttcct cactacattc ccaatgtgat

13681 gcttaaggac agctttgaac ccattcaccc agaccctctg agttgcatgc tcagggagct

13741 cagtgctcca taaaacaaaa acaaaaggtg ccttttgcaa gaaactggat gaaacaagta

13801 gtctgctttt ctggagctca cagtctgccc ttcctttttt ttttttgaga cggagtcttg

13861 ctctgtcgcc caggctggag tgcagtggag cgatcttggc tcactgcaag ctcagcctcc

13921 cgggttcaca tcattctcct gcctcagcct cctgagtagc tgggactaca ggcttctgcc

13981 accccgcctg gctaattttt ttggtatttt tagtagagat ggggtttcac catgttagcc

14041 aggatggtct caatctcttg atctcgtgat ccacctgcct cggcctccca aagtgctggg

14101 attataggca tgagccaccg cacccggcct gcccttcctt ttattgctgg gcaggggcgg

14161 catgaggggt aagtactggg gactaatgtg aataccaccc agaatcccac aactgggtta

14221 ctgtagtgat tttccttttg catatttcct tctggacttt gcatatatga aaaggctcca

14281 ctgatgatct agcataggac atgggccaca ttagtgacaa gaacaccagt gaacaagtct

14341 gattttcatg gagttatgtc acttatttct gcttaaaagt gtcagcccat ctctagagtg

14401 acacttcacc ttgccagaga tggtctctgg agaaagaaag cctgctggaa atgcctcctg

14461 gtgccaactc tgtgcatgct ctgcctccag gtggtacatt ggcagagccc ccatatgcac

14521 gcctactacc cagccctcac ctcttggccc tccctgctag gagacatgct ggctgatgcc

14581 atcaactgct tgggattcac ctgggtgagt agcaacggct gtaactactc gcaatgggga

14641 acgtagcagg gagtggtatc ctagggcaga catattttgt cttggtttct gaatatggct

14701 ccacaataaa tattaatgag ggctatattc tttaagctta cgctttattt taattttctc EPI-109 1216

14761 atcacatcct ttaaccctat ggaatcacga gtattgatcc cattttgtag gtgaagaaat 14821 cgaggcttaa gcaacttatc tcccccagat cacacagctc atagagacac agataagact 14881 tggatacaga tctggttatt gccacagttt gtgaccttac ctaagcaatt tgatgcctat 14941 tgagtcacca cttcctctgt gctcttgtat ttgagtagct ggagatatgt cctaagactt 15001 cccttaataa ccccttaagc accactcagc tttaaatggt gccaaaagcc ttccagaaca 15061 tctttttatt ttaagcctga actcctatgg gtgtgtgggt gggtgggcgg gggtattcat 15121 atcttttcta ggaaaacatc cccctgggca tttgaggact tctcagctat gtattttagc 15181 gacttggaga accaaatcca agccaaccat ttctagggct gtttctccat agagccttgg 15241 agaattcgcc tcattgaggg cagcatgaat ccaaaacccc acattatttt ctcttttggt 15301 tgacagagag tggaccagga gagaggcacg tggcctaaca tgaccccttc tccagaaatg 15361 ttcccattga caccatcagg ggcagacatg tttctggagc tcgtgggggc acctcagtgc 15421 cctggggctg tgcagtttga agttcctttt cctttctcag gcatccagcc ctgcgtgtac 15481 agagctggag atgaacgtca tggactggtt ggcaaaaatg ctgggacttc cagagcactt 15541 cttgcaccac caccccagca gccagggcgg aggcgtcctg caggtacctc ccttggcaaa 15601 gcttcaccta gcttgggggc taagtagcga aagacaagcc aaaccctaac ctggcaattc 15661 tcccgttctc catggagttt cccccacatt acccacaccg tcatcaccaa cagcaccatc 15721 atcacagctt cacctctact cccacctcag cttctgcttc attcacatgt actgctactt 15781 cctttgaaag aaattaaaga gccaacacat gatcacattt ccagtatgac ttgattcagg 15841 tttcttagtc tataatctga caattccttt ttggtgtccc attttgtatc tcacggtaaa 15901 aggggaaagg agaaggcaag gagaggactt ctctttctct ccctgctagg ttcaggagat 15961 ccccttgcag tgagagcaat taacagcata aactgattaa cggtatcctc tgaccctatc 16021 ttctggatac ttgtcaaatt atggttcttc aaatatttct ttttttcaag agtagtgcca 16081 tggagtggag ctttctgggt gcctcccatg gaccacacac attgttaggt gcttttgcat 16141 ctataaatcc ttgacgttca tgagggcttg gttctaagac ctttgagatt cctcagattc 16201 ttgaattctt tttttaaata aaaatcgtgg ctggacatgg tgactcaccc tgtaatctca 16261 gcacattgag aggctgagac agatggatca cttagcccag gagttcaaac cagcctgggc 16321 aacatggtga aactgatctc tccaaacaaa caaaattagc tgggtgtggt ggcatgtgcc 16381 tgtagaccca gctacttggg atgctgaggt aggaggattg cttgagccca gaagattgag 16441 gctgcagtgg gctatgattg tgccactgcc ctccagcctg ggcgacagtg taagaccttg 16501 tctcaaaaaa taaaaaaatt gccatgttgc tctgagatga gaaccaggaa gttcactagg 16561 tcctcttgct agctaagtga ctccctctct cactgcagcc ttgcagcaag attaaaatct 16621 gaacctcgga agaaagacaa attgcagcat gttgtggaca ttttggattg tcagcaaata 16681 gttacaactt cagatatcat atttgggaga acatgctaaa tgtctgcggt acatgatctt 16741 gcttttcatc tgattatctc aggaaccctg caggtgaata gtaccattcc ccaatgtttt 16801 gagataagag cactgaagtt cagagagatt aaataatttg ccctagctta cacagctgat 16861 aagcagaaga acgaggattc aaactgatgc ctgtctaaat ccaaaccatg ctttctcctg 16921 tatcgtcagc catgtgaact tgagttagtc ccatcacctc tctgagcatc actctcctca 16981 tcttagtgtg acaagaatca taattatctc aaagaggtgt tgtgaggagc aagtagaatg 17041 ccagaaagtg ttttgtaaac tatgaattgc aatacagatg gaaggtgttg ttaccattat 17101 tattattttt aaaaacaggg cctggttctg tctcccaggc tggagtgcag tggagccatc 17161 atggctcact gcagcctcca tctcctgggc ccaagcaatc ctccaacctc agcctcccac 17221 gtagctggga ctacaggtgt gcaccactac acctggcttt ttgttttttg ttttttttgt 17281 agagacaggg tctcactatg ttgtccaggc tggtctcaaa ctcctggact caagggatcc 17341 tcccaaagtg ctgggattac aggtgcgagc cactgcaccc agctgattat tattattatt 17401 atgctacata cttctttaca taaatagctt tctttttatg gagtaactcc caggcactta 17461 atatctgtgg gatctggtcc acaccactct ccatgacagt gtctgccagg catttttagc 17521 aggattctat cagctgtagg tcacttgaag atttcaagaa gcaaagacat caaagactgg 17581 gtgaatgaat gataaggaac cataaagact cctgtgaagt tcctgaggtg gccccgaaga 17641 tttccacaat catggccaga gcaaaatcct acccaaccct tgtttggata atctatactc 17701 ccatcctggg aagcagttaa agggatgctc tccatttcat agacagaaaa gagtcttctg 17761 gaggggaaat gttagcccaa ggtcacaaga gctattgaca actaaatggg cccaagtcac 17821 cagcctctca cacaggccag gatcctctct tcctggggac tcaaactcca tatccatttg 17881 tgtaataagc tgagagttct tcttttaaat atgttttaca tggggagcaa acacatccag 17941 gagggacaga acattctctt tttggtttct gtggcctctg taatagagag gctggtatta 18001 ggtgcaaact tattttagaa ggcagaatag gaatgaaagt tggggaggga catgggcacc 18061 ctgggcagga ggagctgtgt atttccttct gtgaatagct atgacacaca catacacaaa 18121 cacatacaca cacagagaga gagagagaga gagagagaga gagagagaga gaaaaaacta 18181 gaaagcctgg ggaaatttgg caagagaata cagaaaggct gccatgataa tccttttccc 18241 ctgcagagca cggtcagtga atccactttg attgccctgc tggcagcaag gaagaacaaa 18301 atcctggaaa tgaaaacgtc tgagcccgat gctgatgagt cctgcctaaa tgcccgactc 18361 gtggcctatg cctctgacca ggtgagttgc ccgacgcagg acagcccttc gggttggtgc 18421 ttggcttctg gaatcttggt ccttgagcaa tttttttcta gacgtgagta cgctggggtt 18481 ctgagcagct cagacatggg agcttgtctc cagcaactgt agggaagaca agcttccaat 18541 gatcatattt ggttcccgag tcttaggctt cagcagtttc tggggggtga tcattccagg 18601 atgactcttt gctgacaggt ttctgtggcc cttctaggct cactcctctg tggaaaaggc 18661 tggtttgatt tcccttgtga agatgaaatt tctgcctgtg gatgacaact tctcactccg 18721 aggggaagct cttcagaagg ccatcgagga agacaagcag cggggcttgg tgcccgtctt 18781 tgtaagtcag gatatatgcc taagcttaga atgatagaac ttggatgtga ggaaggaatt 18841 ttggcagaat tcaggtaagt aacatgctgc acacaaaagc agaaaggtcc tcccatacag 18901 tattttacac atcatgaggt gctatccata ggtgtgttat ggaataaatt ttgtgggtca 18961 taaccagcat taaaaagaaa tatagtataa aatattagag tgcacacata tagccagagt 19021 atgtattgtt ttatgaaact tttttttcaa atacacacgt atacatgtac tagattgtta 19081 tataaaatgt gtttcttacg agccatggta aaacacagtc tgaaatatac actgttctgg 19141 tgggatggat gggagtagat cacgtctgtg gtgaaatctt tctcaggcca aatgtgtcac 19201 acgagcccac cctcctgtgt taacttgcct taattttccc ctaggtctgt gcaacactag EPI-109 1217

19261 ggaccactgg ggtctgtgca tttgactgcc tgtcagagct gggccccatc tgtaagtatc 19321 ttccctc gt ggctaggaag acaaggaata catttttaaa tgtctcctaa agcaaggacc 19381 tgaaaccagc tctatgggat tattcttgtt cctctttggt caatgcagag acatgggaag 19441 aaccaccaaa ggtcatgagg gtctcttcca gggatccctg gacattgcct ttcccagtgg 19501 tgtgacaaga gttagaggtg gcctaccttg cctcctgtcc taggaggcga cagtaggaga 19561 gccttcggtt ttctcatcct cttacttgta tgttgaactt tacttaatgc aggctatatc 19621 caaaatacag tgtgaattag gctagaatag aaatgctttc tattctacct tcagaaaagg 19681 aaaagggtag ggtaggggaa atcatgggag agattaaagg cagagaggaa acccagatgg 19741 gactgtttaa tccccaagca agaaaccact aggaaagaga gataccttcc ctctaacttt 19801 tgtattcggt gcactgacat tgctctctgt gctggtggga aattgatttc tgtgccagga 19861 tgttctaggc tgaggccaag agggtgctgg ccctttaccc agtggaagaa aaaggcaagg 19921 gtgaggcttt gtagactttc ccattcggag gtaatgatgc ctccttcagc cccacttctt 19981 caaactgact ccacctgctc ccatctccac acccctccgt ttctcattta gccaaagcac 20041 atcatccttg cagcccacca ctcagcttgg ccaggtgcga gacatctttc cccacttcat 20101 acctcccctc cggccaggtg atgtttgcct cctcaggtgc ccgtgagggg ctgtggctcc 20161 acatcgatgc tgcttatgca ggcactgcct tcctgtgccc cgagttccgg gggtttctga 20221 aggggattga gtatgccgac tccttcacct ttaatccttc caagtggatg atggtgcatt 20281 ttgactgtac tgggttctgg tgagtgtagc agcccagctc cgagcacgca ggaacgcctt 20341 gcctcctctg gagagacctc agccactaat gcccatttgg aaacccacag ggtcaaggac 20401 aagtacaagc tgcagcagac cttcagtgtg aatcccatct acctcaggca tgccaactca 20461 ggcgtggcca ccgacttcat ggtgagtggc cagggacggg cagcctggtg ggctcgggtg 20521 gccagtggga actgtaggcg tctgaccccc caaaatctgt acggtggctc ccttcagaag 20581 gcagcacact atgagctcat ctcataatac tgccaatgca taccttggtt tctaattgtg 20641 cctaagtata tagaatgaaa cccagaaaat ggttaaaaac cctagaaaat gagaccagcc 20701 tttgaggcag tgtgcacatt tcctgaatat ttgtggcatt ttttaattcc cagaaatgct 20761 cttcctacca caggtggacc agttccttct gcctccatct cgggtcatct tttttgtttc 20821 ttacccagca gcagggcagg gtggagaatt tccctggtgg ggaaagagct ttcttgctga 20881 aatcgctttt gtttttttgt ccctgacaga ggcgctgtgg ggcagctctg tggtagtgat 20941 gggctgcagg acttgtgtga ggttctggaa gcctccaagc attcctgact ttcccaactg 21001 actgcgcctc aactctctaa ctcactctct ctctcttttc ttttgttttc tttctttctt 21061 tctttctttt tttttttctg agacagagtc tcgctctgtc aaccaggctg gagagcagtg 21121 gcgcatcttg gctcactgca acctccgcct tccaggttca agcgattctc ctgcctcagc 21181 tttccaagta tctgggacta caggcgtgag ccaccgcgcc cagcaaacct caactctctt 21241 gattccacat cctcagccag tattttgcct gagggaaacg agttcttaac aaattgactc 21301 cgcagtttga ggatgagccc ttcctttact tgtaggggag acagggatgt aaacgaatgt 21361 attacacata acctggccaa cggaggcagc agagcagagt gggggcaagc ttggtttgga 21421 attccattcc agcagtggcc ctttgggaaa ctaactggac ctctctgagc cttgctttcc 21481 ttatctgtaa aatgagaata gtggcattga ttcatagggt attgtgaagc ttaaatggga 21541 acacgtgtgg atcacctagc aaaatagccg tgtggcaagt gctcaatata tggtaggcat 21601 agtatttctg aaagctcttc tttgaagctg cagagatttg ttaggacagt ggttaggcat 21661 gtaggtgcta aagccagatg gcatgtgttg gagtcctggc tttctgttta ctaacttgtg 21721 tgacctcggg caagtgactt aaactctgtg tccagatttc ctcttgtgtc aaatgaggct 21781 gatgaccaca gttctggctt cttaggcttg ctgtgaggat tatacaaatt aatacactga 21841 agtgctgaga gcagtgtctg acccctgtaa gcatccttcc ttgtgaagag atggttttat 21901 cttatcttct tggacaactg aagtgtcttg cccttttagt cttaaaataa tagcttcgtc 21961 atcacttgat tatactggct attctccctt ggaccagtcc acaccctctt tagatatttg 22021 aagcttttgg attagaattg cagcggtaag cctcacggct tactggtggt gacagaagac 22081 cctctagagg taaagaaaga aagaaaaata atggttcttt atctccactg ctctttctgg 22141 taggttttca gagattttta atgaaaaatt aaaaaaattc cagaacagcc caagggtcag 22201 atatctttag ggataactgt aggtttgctt cctgagtgtg aattgatgcc cattctccta 22261 tgagtgtatt tgggtcatca taactgagga gcattatatt cacccttgcc cttttgaatt 22321 tcatgttacc gtttaaattc atttaccaca gtgcctcagg atcttcccgg ggttcattcc 22381 taggagtttg gagattttac agtgctctct gtcttccaga taactcataa aaatgttaga 22441 gtaaactctt cccagccctg ctctggggaa ccttattatt tttacctctc cacccagaag 22501 gcactgcctt acacttaccc ttcccccacc tttaatccta tggatttgat tttcaagtcc 22561 atgaagaaac tcctagaaaa gtgaagttgc tatctttttc atgatcctga gggtcctcag 22621 agctactctc acctgggccc aatgtctttc ccacccaggt ggctgcagct ttgaacagaa 22681 gctcagtcct gctctgagat gagccagaaa cagggcagca tcccaggaga gaagacttag 22741 gtgcttaacc cctggggtcc tggaatcacc taaaatcagg gctagattct ctgacagcgg 22801 agaagctccc tgttttctgc ctctcactgg acagagagca ccagtggagg gagcgttacc 22861 ttagccttgg caagggagcc ctgcaaggac cttacaagga cacagaggag gctggagatg 22921 cctcaaggta aagaagagcc ctgtcaggct ttatacgtcc agattttttg atccaacaga 22981 aaatgttggc tagaaccact ctgctgagtc agcatggatc agttttggaa tagtgacaag 23041 aaaaggagca actgggaata aggaagattg tgaagaaatc aaaataaaat cacctctgcc 23101 tatcctggtt tatttgctgg taaaataaag tagctctctc tatatatgaa ataaattggc 23161 tataactatc tggaaaccag aaccttttga cagatgatcc ctatcatccg ttcattattc 23221 tcttggagtg tccattggac aagaggtgga gttgacactt tccttgttac agcaattttg 23281 ttccattttc aggttttgat gccttctgct ggcacaaaag cccccaagct gctccccagc 23341 acaacagagt tttgcttgga aatcaaaggc ttagtagttt tctgctgggg aaacattgtc 23401 catcaacaaa ggggtaacat cccaactgtg cctggctcag gaaactgggg tgaagggtga 23461 aggtgaggac atttgtgagg atttgataat cttgtgtatg ggcagataaa tacgcagtgg 23521 gacaaacatt tatttttagt caacagaaat tgtggtagaa actttctgac gtttgaggga 23581 gatgtcatta ggaaaccacg tgactcatta gaataactgt aaatgttttc caaatcctct 23641 gctctatttt cagatctgag aaatcagtct gaaattgatt tggaaatttt cagatgtatg 23701 gtgactgcaa ccttgaactt taagctctgt tgaatttggc caccaggagc aaagagtcaa EPI-109 1218

23761 ttttcatcta acagcggcag aaatttgggt gctcatttga aatctgacag ctggagtgat

23821 ggctctcaga tcacaggaat ctcacaggaa aatgaacaag gcagtgtaag gttaaatagg

23881 ggtcatcttg gctctagaca gaaatgctac tgtgatttgt agctcacatt ttaaaataat

23 1 ctaaatagcc aacacctact gacaacttct tctgaggctc ttggcgttct ttgtcctcac

24001 accacttgcc cgggaggtgc aattggttct ttatgtcccg gactgatgag ccagtgaggt

24061 ggcactaccc aaggtcacac agctagtaag tggcacagct ggaggcgaaa cctaggtctg

24121 cagggctcta gtgtctgtgc tctaactacc atactttaca ttttgggagg aataaaaata

24181 gaactttatt ttctgctatt caaggaatat agattcattt agagtaaaaa tgtatttccc

24241 ttatgttgag tttctgggcc gggatgaaat gtttaaagca gcacttgaaa gcaaagtgcc

24301 cttctcattg gttcagggta atggacttga cttccacttg tctggctctc agacaagtga

24361 ctattggcca ccttcatcag tgatttggtc acacgatggg gcaacccttg gggagcttgg

24421 cttactcctt agcaacagct cccagagtca tggtgacatc gtccatccct ggagggctgg

24481 gcaggcaaca gataatgccc agaaatgccc gagggagtgg ggcacccttg tctctaacct

24541 tgggcactgt gttcctttgt ttctagcact ggcagatccc cctgagccga cggtttcgct

24601 ctgttaaact ctggttcgtg attcggtcct tcggggtgaa gaatcttcaa gcacatgtca

24661 gacatgtatg tagcatgctg ctgtgggggc tgagcctgtg ttcctctgtt ttctcatggc

24721 gaggaaggct ggtttctact ttgcagatct gcctaggaga cttgcggtgt gtggttcagg

24781 tgtctgggcc tgttcctcag ctcctgggac ttgattctct ttgttaacca gaggagcgct

24841 gagcacaaca tgccctgagg gctgcctgat gcctgtcctc tgctgagtgt ctcaccgttc

24901 cccttgctgt cactgagcac tggggagggt tggccccaga gtctggtttg caggaaagag

24961 aaagagaaag taaatcaagg ggaagtgtgt gtggccaggg taggatccta tctgctttgg

25021 aattacctca atggtcacag ctggctgaat acttttagca ctattatgat tatgcctgaa

25081 ataaagctcc cctggccttg gacaggtaga cctaccaagt ctggaacaaa cctccctgca

25141 tcaacaggca tttattgaag gcctattttg cttaatttat ttctattcaa ttcaacaatt

25201 acaaggtatt gtgctaagaa agggacacag aggtaaatga gacaggtgca gcctctctcc

25261 catgttcttc atggaagaag cgggacttaa ctaagaactc tggccactgg cattgttctc

25321 ccacttctac aagagtccac atgcaagaca aagccattga taaaagtagt gggggaagct

25381 gaagacactg tcctttctgc ctatgtgtgt ctttgtcctt ccacctttcc tctagggaat

25441 tccttcttgg ttaaacaaac acaaaccaaa atgaagtggt ggaagcggta actatgattt

25501 tttttaacat ttaaaaaaaa taattattat gcttacataa taattacgta tatatttatg

25561 gggtatgtgt gaggttttga tacaggcata caatgtgcaa tgatcaaatt agggtaactg

25621 ggtatccacc actcaaccat ttatcatttc tttgtgttag aaacattcta gttccattct

25681 ttaagttagt ttgaaatgta cagcaaatta tagttaacta tagttgcctt attgtgccgc

25741 ctaacattag atctatttaa ttgtattttt gcgcccgtta actatcacct ctttatcccc

25801 cattccctgc tacccttccc agcctctgcc aaccatcatt ctactgtgcg tctccacgag

25861 ctcagtttgc ttacttttta actcccacgt ttgagtgaga acatgtgaaa tttgtccttc

25921 tgtgcctggc ttattttgct taacataatg ttctccagtt tcctatgact ggttttaatg

25981 ttggtaattt tacctttgta atcaccactg gttgtttacc aatgagcagc tgccaccaac

26041 aatattgagg aactttaggc actttgtgct gtttctagaa atgcagactc aagactggag

26101 ggttgtgggc ggggaatggt tggtggaggt tacaagtaat taggaacatt tttttgctta

26161 cagtttggga ctggatattc aatgtgcaga tcctgactaa cctcccttag cacttctgtt

26221 tgcaaatcaa acccctgaat tcctcctatt agcaacccca ttgcctacca tatgaggccc

26281 acactcctgg gcctggcttt caaggacttg acgattagct cctaccttag cttgggcatt

26341 tcatcgaccc atccagacct catgctcagt ccatctctgc accttcaccc gtgtccttca

26401 cctgaactac cctctcctct ccaaatgttg tgaatggatt aaattctgct tccactagaa

26461 gcttttctgc ctattccatc tgttctggtt tctgcttcat tagcattcct gtgatcacct

26521 actcaaacac ctttacaaaa ctgtgctcaa agttcttcca atgtcccaca atagaagaaa

26581 tggaattaaa ataaagttgt ttgatatgat ttgattttat ctcttcaact tgacggtgat

26641 gataattatt gacacttgcg taatgccttc aatacaaaaa taaattctag ttcttcatta

26701 gatccttagc acagtgcctg gggtggtcac tctaacctgg caaggctcag agggagtaat

26761 tgccctgctt gagggaagaa ggcccgggac tttccctgaa gcctcccaat tccaaatcct

26821 ttcttcatag ttctgggctg ctttctacta cactgagctc ttggaaagtt atataaaatt

26881 aaatttcata tttctgtgtt acagagaagt gctttaaaga atggattttt agttctaccc

26941 tttacctgtt tgatgacctt agacaaatta cttaaccttt ctatatttgt ctgccttatt

27001 tatttattgt tatttatttt tgagatgcag gtctctgctt gctcaggctg aagtgcggta

27061 gtgccatcag agctcactgc agccttgacc tccccaggct caggtgatcc tcccacctca

27121 gcctcctgag tagctgggac tacaggcgca taccatcatg cctggctact ttttgtattt

27181 tttgtagaga tggggttttg tcatgttgcc caggttgttc tcacgctcct gggctcaagc

27241 aatctgccta ccttggcctc ccaaagtgcg aggattacag gcatgagcca ccacccctgg

27301 ccatgccttc ctaatttata aaaatgagaa aaggatacta cctctctcaa attaaatgag

27361 ataatatata tgcagccctt agcacagggt ctacctacta ctcagttaag tactcaatga

27421 gtacctcttc ctcttctctt cttccccttc ttcatcatct ccttcttcat ctaattataa

27481 taaattgtca tcatcatcac catcatcatc atcatcatcc tcatctccta tcacctacaa

27541 tagggattgg taaacatttc ctgtaaaaag ccagatacta aatacttttg gctttgtggg

27601 ccatactcta ttgtaattac ctctgtacta caagagctac cgtagacaat atgtaaacaa

27661 atgggaatgc tgtgttccaa aaaactttac aaacacaggt gggggctata tttggccatg

27721 gctgcactgt gcctgccctt gacctagagc ggtgcagggc actggcagca gctctgcttt

27781 catgacctgt aaagtggggc tttggaggtg gcagtgctgc ctgtgctctg tattctcctc

27841 tcccctgacc tctgcttctg ttattgcaaa cagcatgtgt tgtaggaggg ataaaagcac

27901 agtgggagga gatctaccta ctgtcacttg taccttggga aagtcacttt cccttggttc

27961 cttctaaaaa atggaaagat tgagctgggc acaggggcac gtgtctgtag tcccagctac

28021 ttgggaggct gaggtgggaa gctcaattgc tcccaccata gcccaggtgg gagttctggg

28081 ctatggtgtg ctatgccaat tgagtgtccg cactaagttc ggcatcaata tggtgacctc

28141 ccaggagcaa gggatcacca ggttgcctaa ggaggggtga aggggcccag gttagaaatg

28201 gagcaggtca aaactcctgt gctgtttgaa actgaccacg caggggagaa aggggctctg EPI-109 1219

28261 agaaagattt ggagaaacta atttcattat ggtcaaaaga caggctcagg gccagacatg 28321 gtggctcatg ccagtaatcc cagtactttg ggaggcctag gaaggaggat cgcttaagcc 28381 caggagtttg ataccagggt gaacaaccta gtgagaccac tgtctttaca aaaaaattaa 28441 aaaatgtagc tgggcatggt ggtgcatgtc tgtagtccta gctactcagg aggtgaaggt 28501 gggaggatta cttgagctca ggagttcaag gctgcagtga gctttgattg tgcaacatgc 28561 ctctgtactc tagcctgtgt gacaaagcaa gaccctatct ctcaaaaaaa aaaaaaaaaa 28621 aaaaaaaaag aggttcagct aactcccttg ccctctcttg aaatagagca gtaagtatga 28681 gaactaactg atagaattac ttagcaaata tttttattga gatcttctgg atgcttggag 28741 aaatttttaa aaagaaaaga gaaggcaagt cctgtccttg tttagttagt aatcctgggt 28801 taaaaacaaa aagcaaaaaa ccccaggaca tttaaaaaga tggtatgaac ttcagtggaa 28861 gattaatata atacaaagcc tttaacattt taaaatgtaa caaaatattc ataccataga 28921 atgtaccatt ttactcattt ttaagtgtac aattcagtgg cattaagaat actcacaatg 28981 tggtgtgacc atcaccatta tttccagaat tttttcatca tcccgagcag aaactctgta 29041 tccattaacc aggtccaaaa cctttccatg atgggtggag acaagatgtg aaaatatgtt 29101 ctctatggaa tgtcagaaac aggggatgaa aagggcattt ggggtacagg gtgagaagag 29161 gtttgagagg caagtgaagc atgtaggctt aggatggggc agggccgcca ctagcccata 29221 tggcaacttg atgtgcacta caaacaggca tctcttcctt taggcacacg cagctcgcat 29281 gaggcacctg gctgggaacg cagagcatgg actgggtttt ggccctcact tgcccacttg 29341 gccagtcaag gagctgtgaa atcaggagtt gaggccgggt tgcctggact gcaaagcaca 29401 tgccttctgg gttctggggc tgagttgaaa gagggccctg agatgagttc tcgaggtgga 29461 tcccatgtga caggaaacag ggcgccattg gaaattttcc agcttggaat atgagcaaaa 29521 tcaaatggag atgacaatga ggcagaagcc gcttacaacg gctgtgacgg gaagatggcc 29581 ctggtttaaa accatttagc agtctgaaag tttatgcata gtctcttgtc tgatgattaa 29641 tctcagttct ctttatactt gcaattccag ggtactgaaa tggctaaata ttttgaatct 29701 ctggtcagaa acgacccttc ctttgaaatt cctgccaaga ggcaccttgg cctggtggtt 29761 tttcgtctaa aggtaatacc atcttccaag cccctctgtg aatgatgtct tgtggtgctc 29821 cagagcctct cggaaacaca aactgggctc tggggatgct gacagggggt gcgatggaga 29881 cttcacttcc tttatttttc aaacagggtc ctaattgtct cacagaaaat gtgttaaagg 29 41 aaatagctaa agctggccgt ctcttcctca tcccggccac tatccaggac aagttaatca 30001 tccgtttcac tgtgacatcc cagtttacca ctagggatga catcctgaga gactggaatc 30061 tcattcgaga tgctgccact ctcatcctga gtcagcactg tacttcccaa cccagccctc 30121 gggttgggaa cctcatctcc caaatcaggg gtgccagagc ctgggcctgt ggaacgtccc 30181 ttcagtctgt cagtggggca ggagatgatc cagtccaggc caggaagatc atcaagcagc 30241 ctcagcgtgt gggagccggt cccatgaaaa gggaaaatgg cctccatctt gaaaccctgc 30301 tggacccagt tgatgactgc ttttcagaag aggccccaga tgccaccaag cacaagctgt 30361 cctccttcct gttcagttac ttgtctgtgc agactaagaa gaagacggtg cgctccctca 30421 gttgcaacag tgtgccagtg agtgctcaga agccactgcc cacagaggcc tctgtgaaga 30481 atgggggctc ctccagggtc agaatctttt ccaggtttcc agaagacatg atgatgctga 30541 agaaaagtgc cttcaaaaaa ctcatcaaat tctacagcgt ccccagcttt cctgaatgca 30601 gctctcaatg tggactccag ctgccctgtt gccctctgca ggccatggtt tagacacagg 30661 gccttcagcc agagtctgag gatatacttc agggactctg tgaacccctc acaattgtat 30721 gccaactttg tgtgcttatg tgtacatgca tttttcttgg ggcgagttca taattttaat 30781 caaattctca taggggcttc atgacccaca ataggataca aacgaagagt ttaagccagc 30841 atgatccaga tgggttcagc agtctggtca gtgagaaagg gccgagggta gacaggcagc 30901 ttctgtggtt cagcttgtga catgatatat aacacagaaa taaattatgc ttgtccctga 30961 aacaaaacat accctgtgtc acttaattgg ctgctgaaac attgattaac cagtctggga 31021 gcttaaacat atgtactttt tttgaagcat caattatgag tcaggcactg tggctcatgg 31081 ttcataaatg aggaaaccaa cgtttaggtc acacagcttt aaataggcaa acccaggtct 31141 cctgcttcca gtgaagccca ggctgtttcc accatgcagt actgctcaag gttggacctg 31201 aacaggagct cacagcccag caggctgctg gtcctccagt acatttaaat gtttcctttc 31261 taggtttgga acttgtgcat tttcccctta ttttcctgga cccggtagtc aaataaaagc 31321 tatgctcaca agtggcttgc ccataattag ttcagaggcc aaacacataa ttttatttcc 31381 atttcagatg gtactttgat aggttgtgac tctgaaatgg gttatgtaaa gagtattaaa 31441 gacaaacaaa gctgggcatt agttagaact ttaaggatag atgttaaaca gtaatatact 31501 atcacaatag ggaaaagggt cccatgtgaa ctgaactcaa cttggatttg tgcaaaggtg 31561 actaggcatt tcacagcgtg aatgggagaa tagggagaag gccagcctag acttagaaga 31621 gtcaggaatg tgaaaaatta caaaaagcgg aaagtggttg atgtgaaacc cctctgggtt 31681 tgctaactgg tgctttttga agtaagactc ttaccctccc acagagactg ggagtcaggg 31741 ccctgtgttc aggggttcgc tggaacaaac agttaattct ttcggcagct ttgagttttc 31801 ttaagcaggc actttaaggt gagctaggat caacttaggg atgtggcctt gagctgtgag 31861 aaactgtgtt agtgtttgtt caagtcttta taggcaaagg ttgaggccta gttgagaagg 31921 gggctcggag gagcttagct agagtttggt cgagaaaaga atctttgtta agagtttaaa 31981 gctttttttt tttttttttt tttttttttt ttgagactag tgctttctct ctttcccagg 32041 ctggagtgca gaggcacaat catgtcttac tgcagcctca acttcctggg cttgagcaat 32101 cctcctgctt cagcctccca agtagctatt tatttttgag atggggtctc attctgtgag 32161 tgcagtggtt ggaacacagt tcactgcagc ctcagcctct gaggctcaag ctgtctttcc 32221 acctcagtcc cacgagtagc tgggactatg agtgcacacc actatgcctg gctaattttt 32281 ataacttttt acagagacag ggtctccctg tgttgcccag gctggtctgg aactcctggg 32341 ctcaggtgat c

(2) INFORMATION FOR SEQ ID NO: 60: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2371 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single EPI-109 1220

(D) TOPOLCG Y: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 60:

1 cgactaagaa gccctgttga cagctgcctt ccagcctcct ctgtctgtct jccaggagga

61 gcaatccaag ggagatgatg gagccctgtg aataccgtga ataccgtgaa tactaccgag

121 ctagagggaa agagatggtg gattacatct cccagtacct gagcactgtg cgggagaggc

181 aggtgactcc aaatgtgcag cctggatacc tgcgagccca gctacctgcg agtgctcccg

241 aggaacccga cagctgggac agcatctttg gggacattga acgagtcatc atgcctgggg

301 tggttcactg gcagagcccc cacatgcacg cctactatcc tgctcttacc tcatggccat

361 ccctgctagg agacatgctg gccgatgcca ttaactgctt aggattcacg tgggcatcta

421 gcccagcttg cacagagctg gagatgaaca tcatggactg gctggcgaag atgctggggc

481 tcccggagta cttcctgcac caccatccca gcagccgagg gggaggtgtc ttacagagca

541 ctgtcagcga atccacttta attgccctgc tggcagcaag aaagaacaaa atcctagcaa

601 tgacagcgtg cgagcccgat gctaacgagt cctccctgaa cgctcgtctc gttgcctaca

661 cctctgatca ggctcactct tcagtggaga aggctggctt gatttccctt gtgaagatca

721 gatttctacc tgtggacgac aacttctcac tccgaggaga agctctccag aaagctattg

781 aggaagacaa gcaacagggc ttggtgcctg tgtttgtctg tgcaacgtta gggactactg

841 gagtctgtgc atttgacagg ctgtcagaac tggggcccat ctgtgccagt gagggactgt

901 ggctccacgt cgatgctgct tatgcaggca cggcctttct gtgccctgag ctccgagggt

961 tcctggaggg catcgagtac gccgactcct tcacctttaa cccttccaag tggatgatgg

1021 tacactttga ctgtactgga ttctgggtca aggacaagta caagctgcag cagaccttta

1081 gtgtgaaccc catctacctc cgacatgcca actctggtgc agccacggac ttcatgcatt

1141 ggcagatccc cttgagccgg cgctttcgct ccattaagct gtggtttgtg attcggtcct

1201 tcggggtgaa gaatcttcaa gcacatgtca gacacggcac agaaatggct aaatactttg

1261 aatctctggt cagaagcgac ccttccttcg aaattcctgc taagaggcac cttggtttgg

1321 tggttttccg tctgaagggt cctaattgtc tcacagaaag tgtgttaaag gaaatagcca

1381 aagctggcca gctctttctc atcccggcta ctatccaaga caagctgatc atccgtttca

1441 ctgtgacgtc ccagtttacc accaaggagg acatcctgag agattggcac ctcatccaag

1501 aggctgctaa ccttgtcctg agccagcact gcacttccca gccgagccct cgggccaaga

1561 acgtcatccc gccaccgcca gggaccagag ggctatccct ggagtcagtc agcgagggag

1621 gagatgaccc agcacaggcc cggaagatca tcaagcagcc aggagccagt ctggcgagaa

1681 gggaaggcgg ctctgatctg gaaacgatgc cggatccctt tgatgattgc ttctctgaag

1741 aggcccccaa caccaccaag cacaagctgt catcctttct gttcagttac ttgtcggtcc

1801 agaacaggag gaagacaacg cggtccctca gctgcaacag tgtgcctatg agtgcccaga

1861 agtcactccc cgcagacgct tcactgaaga atgggggctc cttccgggcc agaatctttt

1921 ccgggttccc agaacaaatg atgatgatga agaaaggtgc cttcaaaaag ctgatcaagt

1981 tctacagcgt ccccagcttt cctgaatgca gttctcagtg tgctcgccag ctaccgtgct

2041 gccccctgga ggccatggtg tagagtcctc aatcagaatg caagggtgcc tgtgcttcag

2101 ggagttgggg aaccctcgaa attgcctgca gtttgtgtgc ttattatgtg tgtgtgcatc

2161 ttgagggaag caagcccatt attttgatca taacctcaca gggtcttcgt gatccacaac

2221 agattgtaac tgggaagttt aagcgggcat gctccagagg ttgcaggcgc ttgtgtgata

2281 gaaggggctg agacggtggc atgctgttaa gcttgtaatg tgaaaaacaa cttagaaata

2341 aattgtgctt atatctaaaa aaaaaaaaaa a

(2) INFORMATION FOR SEQ ID NO: 61: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2355 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 61: 1 cttccacctc ctgcgtgtcc atctgtgaga aggagccaga gcccaaggga gatgatggag

61 cctgaggagt acagagagag agggagagag atggtggatt acatctgcca gtacctgagc

121 actgtgcggg agagacgtgt gacgccagac gtgcagcctg gctacctgcg agcccagctg

181 cctgagagtg ctcctgagga ccccgacagc tgggacagca tctttgggga cattgaacga

241 atcatcatgc ctggggtggt acattggcag agcccccata tgcacgccta ctacccagcc

301 ctcacctctt ggccctccct gctaggagac atgctggctg atgccatcaa ctgcttggga

361 ttcacctggg catccagccc tgcgtgtaca gagctggaga tgaacgtcat ggactggttg

421 gcaaaaatgc tgggacttcc agagcacttc ttgcaccacc accccagcag ccagggcgga

481 ggcgtcctgc agagcacggt cagtgaatcc actttgattg ccctgctggc agcaaggaag

541 aacaaaatcc tggaaatgaa aacgtctgag cccgatgctg atgagtcctg cctaaatgcc

601 cgactcgtgg cctatgcctc tgaccaggct cactcctctg tggaaaaggc tggtttgatt

661 tcccttgtga agatgaaatt tctgcctgtg gatgacaact tctcactccg aggggaagct

721 cttcagaagg ccatcgagga agacaagcag cggggcttgg tgcccgtctt tgtctgtgca

781 acactaggga ccactggggt ctgtgcattt gactgcctgt cagagctggg ccccatctgt

841 gcccgtgagg ggctgtggct ccacatcgat gctgcttatg caggcactgc cttcctgtgc

901 cccgagttcc gggggtttct gaaggggatt gagtatgccg actccttcac ctttaatcct

961 tccaagtgga tgatggtgca ttttgactgt actgggttct gggtcaagga caagtacaag

1021 ctgcagcaga ccttcagtgt gaatcccatc tacctcaggc atgccaactc aggcgtggcc

1081 accgacttca tgcactggca gatccccctg agccgacggt ttcgctctgt taaactctgg

1141 ttcgtgattc ggtccttcgg ggtgaagaat cttcaagcac atgtcagaca tggtactgaa

1201 atggctaaat attttgaatc tctggtcaga aacgaccctt cctttgaaat tcctgccaag

1261 aggcaccttg gcctggtggt ttttcgtcta aagggtccta attgtctcac agaaaatgtg

1321 ttaaaggaaa tagctaaagc tggccgtctc ttcctcatcc cggccactat ccaggacaag

1381 ttaatcatcc gtttcactgt gacatcccag tttaccacta gggatgacat cctgagagac

1441 tggaatctca ttcgagatgc tgccactctc atcctgagtc agcactgtac ttcccaaccc EPI-109 1221

1501 agccctcggg ttgggaacct catctcccaa atcaggggtg ccagagcctg ggcctgtgga 1561 acgtcccttc agtctgtcag tggggcagga gatgatccag tccaggccag gaagatcatc 1621 aagcagcctc agcgtgtggg agccggtccc atgaaaaggg aaaatggcct ccatcttgaa 1681 accctgctgg acccagttga tgactgcttt tcagaagagg ccccagatgc caccaagcac 1741 aagctgtcct ccttcctgtt cagttacttg tctgtgcaga ctaagaagaa gacggtgcgc 1801 tccctcagtt gcaacagtgt gccagtgagt gctcagaagc cactgcccac agaggcctct 1861 gtgaagaatg ggggctcctc cagggtcaga atcttttcca ggtttccaga agacatgatg 1921 atgctgaaga aaagtgcctt caaaaaactc atcaaattct acagcgtccc cagctttcct 1981 gaatgcagct ctcaatgtgg actccagctg ccctgttgcc ctctgcaggc catggtttag 2041 acacagggcc ttcagccaga gtctgaggat atacttcagg gactctgtga acccctcaca 2101 attgtatgcc aactttgtgt gcttatgtgt acatgcattt ttcttggggc gagttcataa 2161 ttttaatcaa attctcatag gggttcatga cccacaatag gatacaaacg aagagtttaa 2221 gccagcatga tccagatggg ttcagcagtc tggtcagtga gaaagggccg agggtagaca 2281 ggcagcttct gtggttcagc ttgtgacatg atatataaca cagaaataaa ttatgcttgt 2341 ccctgaaaca aaaaa

(2) INFORMATION FOR SEQ ID NO: 62: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2396 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 62: 1 agtgcgcagg actggcaaga gggaagccgg gctgctccac gcctttcacg ccttccacct

61 cctgcgtgtc catctgtgag aaggagccag agcccaaggg agatgatgga gcctgaggag

121 tacagagaga gagggagaga gatggtggat tacatctgcc agtacctgag cactgtgcgg

181 gagagacgtg tgacgccaga cgtgcagcct ggctacctgc gagcccagct gcctgagagt

241 gctcctgagg accccgacag ctgggacagc atctttgggg acattgaacg aatcatcatg

301 cctggggtgg tacattggca gagcccccat atgcacgcct actacccagc cctcacctct

361 tggccctccc tgctaggaga catgctggct gatgccatca actgcttggg attcacctgg

421 gcatccagcc ctgcgtgtac agagctggag atgaacgtca tggactggtt ggcaaaaatg

481 ctgggacttc cagagcactt cttgcaccac caccccagca gccagggcgg aggcgtcctg

541 cagcagacgg tcagtgaatc cactttgatt gccctgctgg cagcaaggaa gaacaaaatc

601 ctggaaatga aaacgtctga gcccgatgct gatgagtcct gcctaaatgc ccgactcgtg

661 gcctatgcct ctgaccaggc tcactcctct gtggaaaagg ctggtttgat ttcccttgtg

721 aagatgaaat ttctgcctgt ggatgacaac ttctcactcc gaggggaagc tcttcagaag

781 gccatcgagg aagacaagca gcggggcttg gtgcccgtct ttgtctgtgc aacactaggg

841 accactgggg tctgtgcatt tgactgcctg tcagagctgg gccccatctg tgcccgtgag

901 gggctgtggc tccacatcga tgctgcttat gcaggcactg ccttcctgtg ccccgagttc

961 cgggggtttc tgaaggggat tgagtatgcc gactccttca cctttaatcc ttccaagtgg

1021 atgatggtgc attttgactg tactgggttc tgggtcaagg acaagtacaa gctgcagcag

1081 accttcagtg tgaatcccat ctacctcagg catgccaact caggcgtggc caccgacttc

1141 atgcactggc agatccccct gagccgacgg tttcgctctg ttaaactctg gttcgtgatt

1201 cggtccttcg gggtgaagaa tcttcaagca catgtcagac atggtactga aatggctaaa

1261 tattttgaat ctctggtcag aaacgaccct tcctttgaaa ttcctgccaa gaggcacctt

1321 ggcctggtgg tttttcgtct aaagggtcct aattgtctca cagaaaatgt gttaaaggaa

1381 atagctaaag ctggccgtct cttcctcatc ccggccacta tccaggacaa gttaatcatc

1441 cgtttcactg tgacatccca gtttaccact agggatgaca tcctgagaga ctggaatctc

1501 attcgagatg ctgccactct catcctgagt cagcactgta cttcccaacc cagccctcgg

1561 gttgggaacc tcatctccca aatcaggggt gccagagcct gggcctgtgg aacgtccctt

1621 cagtctgtca gtggggcagg agatgatcca gtccaggcca ggaagatcat caagcagcct

1681 cagcgtgtgg gagccggtcc catgaaaagg gaaaatggcc tccatcttga aaccctgctg

1741 gacccagttg atgactgctt ttcagaagag gccccagatg ccaccaagca caagctgtcc

1801 tccttcctgt tcagttactt gtctgtgcag actaagaaga agacggtgcg ctccctcagt

1861 tgcaacagtg tgccagtgag tgctcagaag ccactgccca cagaggcctc tgtgaagaat

1921 gggggctcct ccagggtcag aatcttttcc aggtttccag aagacatgat gatgctgaag

1981 aaaagtgcct tcaaaaaact catcaaattc tacagcgtcc ccagctttcc tgaatgcagc

2041 tctcaatgtg gactccagct gccctgttgc cctctgcagg ccatggttta gacacagggc

2101 cttcagcaga gtctgaggat atacttcagg gactctgtga acccctcaca attgtatgcc

2161 aactttgtgt gcttatgtgt acatgcattt ttcttggggc gagttcataa ttttaatcaa

2221 attctcatag gggctcatga cccacaatag gatacaaacg aagagtttaa gccagcatga

2281 tccagatggg ttcatcagtc tggtcagtga gaaagggccg agggtagaca ggcagcttct

2341 gtggttcagc ttgtgacatg atatataaca cagaaataaa ttatgcttgt ccctga

(2) INFORMATION FOR SEQ ID NO: 63: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 40298 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 63: gtaagtatct tccctctgtg gctaggaaga caaggaatac atttttaaat gtctcctaaa

61 gcaaggacct gaaaccagct ctatgggatt attcttgttc ctctttggtc aatgcagaga 121 catgggaaga accaccaaag gtcatgaggg tctcttccag ggatccctgg acattgcctt 181 tcccagtggt gtgacaagag ttagaggtgg cctaccttgc ctcctgtcct aggaggcgac EPI-109 1222

Z 4 i agtaggagag ccttcggttt ctcatcctc ttacttgtat gttgaacttt acttaatgca

301 ggctatatcc aaaatacagt gtgaattagg ctagaataga aatgctttct attctacctt 361 cagaaaagga aaagggtagg gtaggggaaa tcatgggaga gattaaaggc agagaggaaa 421 cccagatggg actgtttaat ccccaagcaa gaaaccacta ggaaagagag ataccttccc 481 tctaactttt gtattcggtg cactgacatt ctctctgtg ctggtgggaa attgatttct 541 gtgccaggat gttctaggct gaggccaaga gggtgctggc cctttaccca gtggaagaaa 601 aaggcaaggg tgaggctttg tagactttcc cattcggagg taatgatgcc tccttcagcc 661 ccacttcttc aaactgactc cacctgctcc catctccaca cccctccgtt tctcatttag 721 ccaaagcaca tcatccttgc agcccaccac tcagcttggc caggtgcgag acatctttcc 781 ccacttcata cctcccctcc ggccaggtga tgtttgcctc ctcag

1 gatcacctga agtcaggagt tcgagaccag cctgaccaac atggagaaac cccgtctcta

61 ctaaaaatac aaaattagtt gggcatggtc gtgcatgcct gtaatcccag ctactcagga

121 ggctgaggca ggagtatcac ttgaacccag gagacggagg ttgcggtgag ccaagaacat

181 gccattgcac tccagccttg gcaacaagag caaaactccg tctcaaagaa aaaaaaaatt

241 tttttttgtc aacccatgtg ggtatgaaat tgtttctcat tatttgcatt tcactaatta

301 ctagtgaggt caaacatttt ttccctcatt tcttatccat taaagtttat tctgtgaatt

361 gccagttcat ggccattttg ggggtgtagt ttttcttact gatttattga agtttaatgt

421 ttttctggaa actaatattt tgctagttgt gtgaattgta aatatcttct cccactgtat

481 ttttttaaaa actttttatt gtctgaatta gcacatattt agtgaatgcc tctatgtgca

541 attctttttt tttttttttt tttttttttg agatggagtt tcgctcttgt ttcccagact

601 ggagtgcagt ggcatgatct aagctcactg caaccttcac ctcccgggtt caagtgattc

661 tcctgcctca ggcctcctga gtagctggga ttacaggtgc ccgctaccat gaccagctaa

721 ttttttgtat ttttagtaga gacggggttt catcatgttg gccaggttgg tctcgaactc

781 ctgacctcag gtgatccacc cgcctcggcc ttccaaagtg tagggattac aggcatgagc

841 cagtgagctc agcctctatg tgcaattctt aatgtcaagc tgagggagaa gtctaagaag

901 ttttatataa gtctgacacc cagggtgcct gtaattaaag gtggaatgaa attttaattt

961 gcgagttgat ccttctgttt tttagttcag tacttcctcc tttttagaat gtatgctttc

1021 cagataatta gtgagataaa gatttgattt tcacttttag catttctaaa agctgtaata

1081 tgctacctaa cttgttttta attcttgctc taacttctga tattttatag ttgtgtattt

1141 tgaattatat tttaaaggat taagtggatt attgcacatg atatttagta aagtgtttgg

1201 gagcatttag cacagcctcc aaaaattaga attccactag ccccctgatc ctacatatct

1261 ggcatcttaa gagtcaataa tagcaaagtt gagagaggca gcttggtgtg gtggaaagaa

1321 catgggtatt ggatccgata gccttaggtt caaatcctgg cttcttcagt aattatcttc

1381 tgtaatttta gccaagtgtt taatttcctt gagactcagt ttctcgaaga tgaagtagaa

1441 aatggctttc accaggttgt tgtaaagact gaatcaaata gtgtgcatga aaattgcaag

1501 gcatagtgct caggacatag ttaacattct taaatatatg ttgaggaatg gtgtgcacct

1561 gaaaattcct ataaaagctg caaatataca tgccttttga tccagctgtt ccacttcagg

1621 atatccttac tcatgtgtgc aaagcaattt tttgtagaaa tgtttgtaat agcaaaagac

1681 tggaaacaac tgaaatgtac actgctaggg aactgattac tctctggtat gtccacgcaa

1741 tgcagctcta tgaaaaaaag gagtacgtgt caagatatat taacaaataa agtacagaat

1801 attgtactgt acttatccct tttgtgttta acaaaagaaa gaaaaggaga aaaattagaa

1861 tatagtatat atttgccttt atgtgcaaaa aaaggaaatc actttttgtt ttttttgaga

1921 cagggtctca ttctgtcacc caggctgggg tgcagtggcg ctatcacggc tcactgcaac

1981 ctcaacctcc caggctcaag cgatcctccc gccacagcct cccaagtagc tgggactaca

2041 ggcacacgcg ccatgcccag ctaatttatt tatttatttt tggtagagat ggggtttcgc

2101 gatgttaccc aggctggtct caaactcctg agttcaggtg atccacctgt cttggcctcc

2161 caaagtgctc tgggattaca ggcatgagcc actgtgcctg acctcttttc ttcttgatgt

2221 gaaattcttc atagattaga caaatttgcc cattgtgcaa atatgttgca aatatatttt

2281 ctcagtttgt catttatctt gatttttctt atggttttaa aaaaatgtga ttggatttat

2341 ggtttctggc attgaaccat agttataaat gtattcttta ctctgaggtt gtccagggaa

2401 tcttctaatt ttcttaattt aattttcatc ttttaaaaac agctctattg atgcataatt

2461 gatatacaaa aatagcatat atttactact atttgatgag tttggacatg tgtacacacc

2521 catgaagcca tcagttaacc tgatggtggt gatggtttcc tgtaatttta tgcttccatt

2581 tttcacattt agatctgact tttctggaat ttatctaagt gcacgatgtg aaagatagat

2641 acagcttatt tttctttcca gatggctata ccttgttcta ggacaattta ttaaatagtc

2701 catctttttc tttctgatct gagatgctat ctttattata tgctaaattt ctgtacatgt

2761 ttaaatttat ttgctccttt tgtttgtctc tttgtacacc agtatctacc tcattgttct

2821 aattattcga gcttcaggat acattttaat acttctgggt aggaacagaa ccttctcgtt

2881 actcttacaa aattttcttc tttattctgg tttatttttc ctaagaactt taaaagttgg

2941 cactgaattc caaaatagaa cacccaaaaa cctgttgatt tttccactgg gattatgtta

3001 aattttcggg ttaacttagg ggaaaaccat tatttcatga tgttaaatct tactccatga

3061 gagagcatgg tacgtctttt catctgtaca ggtctttttt tatattgttc agtagcaatt

3121 taaaaaaatc atccactatg ttcaatgaaa taaaaggcca gatttaaaaa tttggcaagg

3181 agttgaaaac tataaaaagg aaccaaataa aaattctttt tttgccccca taaggcagaa

3241 gaaatacaaa ttctacaact gaaaaaatat aatatctgat attaagaaat caataaatgg

3301 tttattatat tagctacatt tgaagagaca actaaaaaag aaaaatattt tcaaaccaac

3361 tcagaaacaa gaagatggaa aataaagaat acaatgctat ttatatttat atataatagt

3421 atatataata cacaagttta acataggact gcatttgcag aatagaagag agataatggg EPI-109 1223

3481 gagatagcaa cacttggaga aaaaataacg gcctaacttg

3541 gctgggtgtg gtggctgaca cctgtaatcc caacactttg ggaggctgag atgggtggat

3601 catttgagcc caggagttca agaccaactt gggtaacatg gcgaaacccc atctctacag

3661 aaaaactcca agaaataaaa aacaataatc atctgagtgt ggtagcacat gcctgcgtcc

3721 ttgctactca ggaggtgggg gtggcagaat taccagggcc tggaagtcaa ggctgcaatg

3781 agctgtgatc gcatcactat acttcagcct ggttgacgag tgagaccctg tctcaacaaa

3841 taaaaataaa aataaaaata aaaatgccta acttggtgct tggcactttc taaaattgac

3901 acataatatt tgtacctgtt tatggagtat atgtgatatt ttgatacatg catacaatgt

3961 gtgtaatgat caaatcagga tatttaagat atccatcatc tcaaacattt ttctttgtgt

4021 tcagaacatt ccaaatctag ctattttgaa atatacaata aattattaac tatagtcatc

4081 ctaatgtgct attgaatatt attgaattcc atctaattat atgtttgtac caattaacca

4141 atctctactt attcctcacc cccagctccc accaaccctt tccagtctct ggtaactatc

4201 attttattct ctacctccat gagatcaaat tttttacctc ccatatcgtt gtcaatatta

4261 ttatttttcc caccctggct cctaatgaag gatttattga caatatcact ggaatctaaa

4321 tcctctaggc cattttttca ccaatgccct tattttctta gggctttttt ttttcttaaa

4381 tcaacagttt taatgagata taattcccat tctataaaat ttcctcgttt gaagtgtaca

4441 gtttaatagc ttttagtata tccacagaag tgtgcaacca tcaccataat aaattttaaa

4501 acattttcag cagggcgcag tggctcacgc ctgtaatccc agctactcag gaggctgagg

4561 caggagaatt gcttgaaccc aggaggcaga ggtttcagtg agccgagatt gcaccactgc

4621 aatccagcct gggccacaga gtgagactcc atctcaaaac aaaacaaaac aaagcaaaat

4681 aaaacaaagc aaaataaaac aaaaccaaaa cccaacaatt ttgaacattt tcatcttacc

4741 accctgccaa aaatccctgt tctccttagc catcaatctt cagctcccta cccacttcta

4801 accatgaatc tattttgtag atttgtctat tctcgatatt tcatatgaat gaaataatat

4861 aatatatggt tccttgtgac tagtttcttt cacttagtat gtttccaagt tcatccatgt

4921 tttggtatgt atcagtactt cattcctttt tatcatggaa taatattctg ttgtattgat

4981 atactacgtt tcattcattc atctgaacat ttggattatt tccatttttg tctattataa

5041 taattctgct atgaacaccc atgtatacgt ttttgtgtgg acatgatttc attttccttg

5101 gatatacacc tagcagtaga attgttgagt cataaagaac tctaggttta gctttctggg

5161 gagcttccag attattttcc aaaatggctg tgccatttta cattcccacc agtaaagtat

5221 gagggttcta atttttccct gtcttcacca atacttgttg ttatctatct tttttattat

5281 agtcatcata gtctgtatga agtgatttct cactgtagtt ttttcagtag taattaaaaa

5341 atttcctacc tattttagcc taaaattact ttcctgactc tcttcaagga gcctgccaga

5401 gaattctctc tctcgtgctg tctcccttat gcctgggcat aagctctgat aatgccctgt

5461 ctgggaaaac tcttttggcc ttctcaattt ctattacatt gagagcccaa gaacccatgg

5521 tcagtaacag gccaatgaga agcctcctgc attagtctag gtgaaggata atggtggctt

5581 ggaccggaat agggtggtag tcatggaaat ggggagaatt tgacagacta gatttatttt

5641 ggaaatagaa ctgaatctga acagattgaa ttgggcaggg agcagggaaa gtgaagggga

5701 aggaagacac caggtttatg ccttcagcat ttgggtggat gaatggatgg atgaaaggat

5761 agatggatgc atggatggtg gttggatgga tgagtggttg gatgaatgga cggtcaaggg

5821 gtgaatagat gggtggatgg aaaatggaga gatgatgaac tgagatgggg aagactagaa

5881 gtggggcata tttttgggga aagacagttt tgcaatacgt taagtttgag gtgcctcaga

5941 gtcataagag aggatttgtc agaaaggcag ttggatataa gattttgaag ctcaaaagac

6001 agggagggcc tgatggtatg tttaaaccta tacggatatc acataggtaa catttcaagc

6061 ctaagaaatg ggccgggcgc agtggctcac acctgtaatc ccagcacttt ggaaggctga

6121 ggcgggtgga tcacttgagg tcaggagttc gagacaaacc cagccaacat ggtgaaaccc

6181 catctctgct aaaaacacaa aaattagtgg ggcatggtgg cacatacctg taggcccagc

6241 tactcaggag gttgaggtgg gagaattgct tgaacccggg aggcagaggt tgcagtgagc

6301 caagattgcg ccactgcact ccagcctggg cgacagagca agactccgtc taaacaaaac

6361 aaaacaaaaa aagccttaga aatgggcaat gccaccaaag cagaaagatg aaaggagggc

6421 aatgccctga ggtgtgccag cattggagga aacaaacagc cagagatgta ggaggaaagc

6481 ccagagaaac tgtgagctgc aaggatgaag tagtaacaaa taaaatgcca ccaagagaac

6541 cagaaggacg actggaaaca aataaacaag aaagactatt gcatttagca acgtgaaaac

6601 gttggattac tttttactca gaaatcaaac cccaaggata gtgtttcccc tccctacggg

6661 gtttctgcag gtccctttac acgccccctt ctacttcttt aagtgctaaa agtgattaat

6721 ttggggtgat gttttaattt ctattctttt tggcttataa ctgtgttttt tcattctttg

6781 caacaacaga tagtatgttg taatagaaaa atccattgtg gtcaatgata acttctgcct

6841 gttcctgggc acagggggca tcactattag tgcctgttcc tccctcccta ctgctgataa

6901 ggaaacaggg gcaggaataa tactaataat ttgtgctact ttttctgcat acccttggcc

6961 ttattctggt ctactgagct gggagcttgt ctgaggctgg agctctattg tctgaatcca

7021 ggggcagaaa gaactgaggg ctcttttacg gcatccacct ggaggctgcc tgcaggcttg

7081 ggttgctaag tgcactgctt aatttagaag cgccttttat cctggctctc ttgaccagtc

7141 aaagttgtgg tcgctgtttt ctacaaggac tggggaaaga aagggtggaa ttaattaaac

7201 ctggaggaag ggactttgaa gggcggagct aaggtcaaag aaagaaccct ttaaataaag

7261 ggcccacact ggctgccagg gagtgcgcag gactggcaag agggaagccg ggctgctcca

7321 cgcctttcac gccttccacc tcctgcgtgt ccatctgtga gaaggagcca gagcccaagg

7381 gagatgatgg agcctgagga gtacagagag agaggtgagc aacgggcatc cctggccctc

7441 ttccctgctg ctactcctgc aggaacggct gctggtgggt ggcccttaga ttgtggggtg

7501 acatttgatg ggagcattag aattgccttc tgagagttgg caccagcaac attttttttt EPI-109 1224

7561 ctgcgaaagg aatgtgggat cagagtgtaa aacttttctc aaccactctt tcattctccc

7621 tctcatatac ccactctcac atatgtccac actaccgtgc ctccccactt

7681 tcccacaaaa ttgaggattt ggatccctga gccactagat gggaaaaggg gattgttcat

7741 attctgaaat agaaaaaaat tttctcaata ttctgtaatc actgcaaatc ctttctttct

7801 taacattcat tccttcatgt gtgaatctat cagcagtgtt ctttcattta gtcattcatt

7861 tcataaatat ttagtaggtg cctactctgt atcaggcaaa accaagtggt tatccagttc

7921 tcaggcatgg atctccctta gcaggaaagt aggtagttgc ttaaaaaaga atcttgaatg

7981 tctatttcta taatgtttta tatcctccta ctcactaatt agtgtgcgtt agcttattcc

8041 attgctttcc taaggcactg tcagctgaga gcaagttcct gtggatattt atcttctgag

8101 tggaacacaa atacatttag cactgttcct ggatcagtgg agggttaggt ctagagctct

8161 cagatctctg gtggggccct gctggagaag aaccaggatg tgagagggtt gaaggggagc

8221 agaaggaaga tagaatggtg tggaaatcta cctttgtctc ataagttttg tctggggttg

8281 gttctgttct taagaacttt gcataagctg atgcagaggg gagaaactga gtcccctctc

8341 ctaggtaaaa gcagcccagg gagtactaag gaatggatgt tgagacagac aaagagatat

8401 gtacacacac acacatgcac acacagcaac agaggcactg aagactgcaa tctgaaagaa

8461 taaataattt gcaatagttt cagagtgttc aacttgactt ttttttcctt ccttactcat

8521 atgttcattc acttgataca ttttttttta gcatctaaaa aatatcctaa gcactgaggt

8581 gttgatggag gcagcaggag ggagagaaag tcattaagat ttggtgccac atttcccagg

8641 ccagggcagg gggcttggtc tggatccatg gttgtgcttt agggattctg tgagcctcag

8701 aaattataca caaagttctg tgtatatgta agcctacagt tttaatcaga ttcttgaatt

8761 aagtcctcat atgagtccaa aaaagatgaa taataactga ttcaatgggg atggtgaaaa

8821 aatagatttt tttgtccttt atcggaactg ggcatggaat ctttctatct gtgctaacag

8881 atataactgg tgggtgtgtg tgtaacaatt tttggataca aagagctata gagtttctat

8941 tgaacctata aaatagttaa tagatgttct gtttctgaga aggaaagaaa ggtaggagag

9001 acaatcaaaa ttgaagtgga taaaggaagg ggaaagaaaa tgaaacgttt cactttggcg

9061 ctagagtttt gtgctttgga gattttcctt tttgttcatt tgctcactta gaaactccct

9121 ccatcattca ttcactccct cactcttttt ttaaattctg aagataaggt cgtgcagggg

9181 atcagatcct accctcggcc catgaatctg tctctctctt ttttttgagt ccaggctgga

9241 gtgcagtggc acgatctcgg ctcactgcaa cctccgtctc ccaggttcaa gcgattctcc

9301 tgcctcagcc tcccaagtag ctgggattac atgcgcctgc caccacgccc ggctaatttt

9361 ttgtattttt agtagagagg ggtttgacca tgttagtcag gatggtcttg atctcctgac

9421 ctcgtgatcc gcctgcctca gcctcccaaa gtgctgggat tacaggcatg agccactgtg

9481 cccggccaaa tccatctcct tctttaccaa gtctcttggc ccggacctga gagggatggg

9541 cacaaatcgg tcaggcccag tcaggggatt tcagcctgat ttctctatgt cacttctagg

9601 gagagagatg gtggattaca tctgccagta cctgagcact gtgcgggaga gacgtgtgac

9661 gccagacgtg cagcctggct acctgcgagc ccagctgcct gagagtgctc ctgaggaccc

9721 cgacagctgg gacagcatct ttggggacat tgaacgaatc atcatgcctg gggtgagaca

9781 cagtgaccac aagggcagtt ctggatttca gggcacagaa gggtgggtgg tggcctggag

9841 aaagacctgc tttgggtcag cttgggatga gaatgcatcc ttcagccact tggccaccaa

9901 caccccagcc catctgctag gcatgtggag ggcaggactt tgactggtat taggtttctt

9961 tttctttttt tttgcccagt tgtgccatgg catgaggttt ctgatgccag ggcagggctg

10021 gccagaacac ctgcattcca gagcacagcc tggcagaagt gtggaagtct aatgggatgg

10081 gtggagaagt gaacattttg tctgagggga aaggacactg tgtatagtaa gacaggggag

10141 aggaagctgg tggtagtgcc tggccctgac gacggagcca gagactcttc tgtacagtgt

10201 ctgagaccac accaaagaga aggaaggaag tggggaacac atcctggcaa ggacacgctg

10261 gtgaccaggt tgcgttggcc caggaaactg agtgggccct ggcaacccct cctgtcccct

10321 ctgaggtctg gtgattgagc tgcttttcaa gagcaagaag ggactttccc tgaatcattg

10381 atactttcca tgatggaggg tgcagcctgg gatagtgctg gtggggccag gaagctgatg

10441 gaagctggct gatgcatggg cttgagctgg agcctgcctt gatgggtggt ggacacccct

10501 gaccactggc ggtgaggagc tctgccatgg tgctcatgct aaagtggcat cgactccctt

10561 cctgtggcgg ggctccctgc catgtgccag ctctgtgctg gccacatgac atgctatcta

10621 atttaatctt cccagtggcc ctgttttaca gatgaggaaa ctgctgatgc tcagagaagt

10681 taactgtctt gcccaaagtc acagaattag tacctggtag atccaggatt ttaccctaga

10741 ccagtcttac ttcacaggct gtgccgtttc tcctaccccc tgtcacctct actggtgggt

10801 gcctgaatgt gcctggctaa gcctgggccc ctagcattgc ctgtctggct ccacaccccc

10861 acacaagctg tgtcttccct ctccctgctt ggggcatttg tgttctgaac cacacatgtt

10921 tagaggctct tcctgaggcc agcttgaggt ttgccttcat cattcccaaa gaacttttga

10981 cttcaatgtg acaaaaaggc caggcgcggg ggctcacacc tgtaatccca gcactttggg

11041 aggccaaggc aggtggatca cctgaggtcg ggagttcaag accagcctga ccaacatgga

11101 gaaaccccgt ctctactaaa aatacaaaat tagctgggca tggtggcaca tgcctgtaat

11161 cccagctact tgggaggctg aggtaggaga atcgcttgaa cccgggaggc ggaggttgcg

11221 gtgagctgag atagcgccgt tgcactccag cctgggcaac aagagcgaaa ctccatctca

11281 aaaaaaaaaa aaagtgacaa aaatatgcct agaggcaggg gtgggaaaat attcaaactc

11341 agaaagtgat ggcaattttg actttttttt tttttttttt ttgaagcaat agagacaagg

11401 tcttgctatg ttgcccaagc tggtctccaa ctcctgggct caagtgatcc tcctgcctcg

11461 gccttccaaa gtgttgggat gagaggccta agccactacg cctggccatg agggcaattt

11521 catacaaagc cactcatctc tttgaccatt cagcctattt cacaagcatt ttttgaaaat

11581 gtcaatatca gtaaggcttt acggaggcta gatcctgata agattatctc ctggatttta EPI-109 1225

11641 ttctgtaaaa tgtaatctgc tgaggggcta actgtaatct gggagtgaga ctgaaagcaa

11701 ctgtcagaag aggtggaaat gagctgattc atttgatcaa gaggaattcc agcagttgct

11761 gtgggtatgg tcggtgaggc tcatttctgg aaagaggtct gtttgttttt gataagggct

11821 cttctggcta ttttatctta tttatcttac aagaacagac tattgtctct tgatagagct

11881 aggaggtaga agcccttctc tggggtttcc aaaatactgt cactaaggac agtgataatg

11941 atggtcaaat ctctcaactc atctctcagg ccacaccagc ctctgagagc tggcctgaaa

12001 gcagttggcc ctttgcttac tcattttgct cagtgcctca ttgaaaactg aattagtttt

12061 tctcttcctg ccaccaccta gaaaataaga gaagaagaaa aactctcttt cccctttaat

12121 tccaaccctg gttagacaat cctcatttac ttttcatgag agagagagag catccccacg

12181 ggaaaagtca ggacaccacc ctgctcgggt gtctgggctt ctgcctcatt gcggtcacct

12241 gtccctatgg ggtatgtgtg accacaggga tgtggcctct ctctgtcagc cccagttctc

12301 gcctgcaaaa cagagataat gtgtaggtcc taccccatag ggtcctgtga gaagtaagta

12361 agagaaggct tggagagcag gagatgtggt tattaccgat catgactctt acatggtgaa

12421 aattggagga agaggtttga ttctctgagt caagtcagga tatgtgatgt gtctgtcacc

12481 cacatgatta gtttaccgtt aatgttagag cttaacattt cacacatttc ttgcccacgc

12541 ctccacccac acaacaaccc taggagacag gatttatttt acgatgagaa actgaggttg

12601 agggaggtgc aggagaggct cctggtctta tggggtctgt actgtaaaca ctttttgaga

12661 cctccttttg aaaaacaaaa aagaaggagg ccggacacag tggtgcacgc ctgtaatccc

12721 agcactttgg gaggctgagg cgggtggatc atgaggtcag gagttcgaga ctagcctggc

12781 caacatagtg aaacactttc tctattaaaa atacaaaaaa ttagccaggc atggtggtgg

12841 gcacctgtaa tcccagctac ttgggaggct gaggcaggag aatctcttga acctgggagc

12901 caggggttgc actgagccaa gatggcgctg ctgcactcca gccctggtga cagtgcgaga

12961 atctgtctca aaaaaaaaaa aaaaagaatg aatctcaaaa gagacccaca caaatggtat

13021 gttggagctt aagttcatta gcttcatggt aaatctacac ggtcacacag ctggttaggg

13081 actgaggtgg gatgggaact tgtgtccttg gacttaattc ttaggctcct tatactatac

13141 acactgtcca ggacaaggtc cttgctcttg aaggactcta agtatgtgtg gacagtaaag

13201 aacaggatga tgccctaaga tgttatcaaa tgagtcctca gtagagtgaa acatctagaa

13261 ttctagagtt ctatcgctca gggaagggat cgaagggagc tgtgggagct gggggagagt

13321 tcgaggagga aatgaatatt tagtagcttt ctaagaactg gcaggttttg gaaggtcatg

13381 tctttataga gagtgccttt ctatcagggg acacagcatt gctcaaagac ataaatgcag

13441 aaaggaacag ggcatgcttc agagcagtga gatgaggaga gatgagataa tccatgaggc

13501 cgatgaacca ccagggctgc ttctgagttc tgatgggggg cccttcctgc ccactcagct

13561 cctccttaca tccggttttg attgtgggct cagggcttag cctggaggtc ggcctcccat

13621 acgcttggtc tgggctctcc tctctaccgt ctcctttcct cactacattc ccaatgtgat

13681 gcttaaggac agctttgaac ccattcaccc agaccctctg agttgcatgc tcagggagct

13741 cagtgctcca taaaacaaaa acaaaaggtg ccttttgcaa gaaactggat gaaacaagta

13801 gtctgctttt ctggagctca cagtctgccc ttcctttttt ttttttgaga cggagtcttg

13861 ctctgtcgcc caggctggag tgcagtggag cgatcttggc tcactgcaag ctcagcctcc

13921 cgggttcaca tcattctcct gcctcagcct cctgagtagc tgggactaca ggcttctgcc

13981 accccgcctg gctaattttt ttggtatttt tagtagagat ggggtttcac catgttagcc

14041 aggatggtct caatctcttg atctcgtgat ccacctgcct cggcctccca aagtgctggg

14101 attataggca tgagccaccg cacccggcct gcccttcctt ttattgctgg gcaggggcgg

14161 catgaggggt aagtactggg gactaatgtg aataccaccc agaatcccac aactgggtta

14221 ctgtagtgat tttccttttg catatttcct tctggacttt gcatatatga aaaggctcca

14281 ctgatgatct agcataggac atgggccaca ttagtgacaa gaacaccagt gaacaagtct

14341 gattttcatg gagttatgtc acttatttct gcttaaaagt gtcagcccat ctctagagtg

14401 acacttcacc ttgccagaga tggtctctgg agaaagaaag cctgctggaa atgcctcctg

14461 gtgccaactc tgtgcatgct ctgcctccag gtggtacatt ggcagagccc ccatatgcac

14521 gcctactacc cagccctcac ctcttggccc tccctgctag gagacatgct ggctgatgcc

14581 atcaactgct tgggattcac ctgggtgagt agcaacggct gtaactactc gcaatgggga

14641 acgtagcagg gagtggtatc ctagggcaga catattttgt cttggtttct gaatatggct

14701 ccacaataaa tattaatgag ggctatattc tttaagctta cgctttattt taattttctc

14761 atcacatcct ttaaccctat ggaatcacga gtattgatcc cattttgtag gtgaagaaat

14821 cgaggcttaa gcaacttatc tcccccagat cacacagctc atagagacac agataagact

14881 tggatacaga tctggttatt gccacagttt gtgaccttac ctaagcaatt tgatgcctat

14941 tgagtcacca cttcctctgt gctcttgtat ttgagtagct ggagatatgt cctaagactt

15001 cccttaataa ccccttaagc accactcagc tttaaatggt gccaaaagcc ttccagaaca

15061 tctttttatt ttaagcctga actcctatgg gtgtgtgggt gggtgggcgg gggtattcat

15121 atcttttcta ggaaaacatc cccctgggca tttgaggact tctcagctat gtattttagc

15181 gacttggaga accaaatcca agccaaccat ttctagggct gtttctccat agagccttgg

15241 agaattcgcc tcattgaggg cagcatgaat ccaaaacccc acattatttt ctcttttggt

15301 tgacagagag tggaccagga gagaggcacg tggcctaaca tgaccccttc tccagaaatg

15361 ttcccattga caccatcagg ggcagacatg tttctggagc tcgtgggggc acctcagtgc

15421 cctggggctg tgcagtttga agttcctttt cctttctcag gcatccagcc ctgcgtgtac

15481 agagctggag atgaacgtca tggactggtt ggcaaaaatg ctgggacttc cagagcactt

15541 cttgcaccac caccccagca gccagggcgg aggcgtcctg caggtacctc ccttggcaaa

15601 gcttcaccta gcttgggggc taagtagcga aagacaagcc aaaccctaac ctggcaattc

15661 tcccgttctc catggagttt cccccacatt acccacaccg tcatcaccaa cagcaccatc EPI-109 1226

15721 atcacagctt cacctctact cccacctcag cttctgcttc attcacatgt actgctactt

15781 cctttgaaag aaattaaaga gccaacacat gatcacattt ccagtatgac ttgattcagg

15841 tttcttagtc tataatctga caattccttt ttggtgtccc attttgtatc tcacggtaaa

15901 aggggaaagg agaaggcaag gagaggactt ctctttctct ccctgctagg ttcaggagat

15961 ccccttgcag tgagagcaat taacagcata aactgattaa cggtatcctc tgaccctatc

16021 ttctggatac ttgtcaaatt atggttcttc aaatatttct ttttttcaag agtagtgcca

16081 tggagtggag ctttctgggt gcctcccatg gaccacacac attgttaggt gcttttgcat

16141 ctataaatcc ttgacgttca tgagggcttg gttctaagac ctttgagatt cctcagattc

16201 ttgaattctt tttttaaata aaaatcgtgg ctggacatgg tgactcaccc tgtaatctca

16261 gcacattgag aggctgagac agatggatca cttagcccag gagttcaaac cagcctgggc

16321 aacatggtga aactgatctc tccaaacaaa caaaattagc tgggtgtggt ggcatgtgcc

16381 tgtagaccca gctacttggg atgctgaggt aggaggattg cttgagccca gaagattgag

16441 gctgcagtgg gctatgattg tgccactgcc ctccagcctg ggcgacagtg taagaccttg

16501 tctcaaaaaa taaaaaaatt gccatgttgc tctgagatga gaaccaggaa gttcactagg

16561 tcctcttgct agctaagtga ctccctctct cactgcagcc ttgcagcaag attaaaatct

16621 gaacctcgga agaaagacaa attgcagcat gttgtggaca ttttggattg tcagcaaata

16681 gttacaactt cagatatcat atttgggaga acatgctaaa tgtctgcggt acatgatctt

16741 gcttttcatc tgattatctc aggaaccctg caggtgaata gtaccattcc ccaatgtttt

16801 gagataagag cactgaagtt cagagagatt aaataatttg ccctagctta cacagctgat

16861 aagcagaaga acgaggattc aaactgatgc ctgtctaaat ccaaaccatg ctttctcctg

16921 tatcgtcagc catgtgaact tgagttagtc ccatcacctc tctgagcatc actctcctca

16981 tcttagtgtg acaagaatca taattatctc aaagaggtgt tgtgaggagc aagtagaatg

17041 ccagaaagtg ttttgtaaac tatgaattgc aatacagatg gaaggtgttg ttaccattat

17101 tattattttt aaaaacaggg cctggttctg tctcccaggc tggagtgcag tggagccatc

17161 atggctcact gcagcctcca tctcctgggc ccaagcaatc ctccaacctc agcctcccac

17221 gtagctggga ctacaggtgt gcaccactac acctggcttt ttgttttttg ttttttttgt

17281 agagacaggg tctcactatg ttgtccaggc tggtctcaaa ctcctggact caagggatcc

17341 tcccaaagtg ctgggattac aggtgcgagc cactgcaccc agctgattat tattattatt

17401 atgctacata cttctttaca taaatagctt tctttttatg gagtaactcc caggcactta

17461 atatctgtgg gatctggtcc acaccactct ccatgacagt gtctgccagg catttttagc

17521 aggattctat cagctgtagg tcacttgaag atttcaagaa gcaaagacat caaagactgg

17581 gtgaatgaat gataaggaac cataaagact cctgtgaagt tcctgaggtg gccccgaaga

17641 tttccacaat catggccaga gcaaaatcct acccaaccct tgtttggata atctatactc

17701 ccatcctggg aagcagttaa agggatgctc tccatttcat agacagaaaa gagtcttctg

17761 gaggggaaat gttagcccaa ggtcacaaga gctattgaca actaaatggg cccaagtcac

17821 cagcctctca cacaggccag gatcctctct tcctggggac tcaaactcca tatccatttg

17881 tgtaataagc tgagagttct tcttttaaat atgttttaca tggggagcaa acacatccag

17941 gagggacaga acattctctt tttggtttct gtggcctctg taatagagag gctggtatta

18001 ggtgcaaact tattttagaa ggcagaatag gaatgaaagt tggggaggga catgggcacc

18061 ctgggcagga ggagctgtgt atttccttct gtgaatagct atgacacaca catacacaaa

18121 cacatacaca cacagagaga gagagagaga gagagagaga gagagagaga gaaaaaacta

18181 gaaagcctgg ggaaatttgg caagagaata cagaaaggct gccatgataa tccttttccc

18241 ctgcagagca cggtcagtga atccactttg attgccctgc tggcagcaag gaagaacaaa

18301 atcctggaaa tgaaaacgtc tgagcccgat gctgatgagt cctgcctaaa tgcccgactc

18361 gtggcctatg cctctgacca ggtgagttgc ccgacgcagg acagcccttc gggttggtgc

18421 ttggcttctg gaatcttggt ccttgagcaa tttttttcta gacgtgagta cgctggggtt

18481 ctgagcagct cagacatggg agcttgtctc cagcaactgt agggaagaca agcttccaat

18541 gatcatattt ggttcccgag tcttaggctt cagcagtttc tggggggtga tcattccagg

18601 atgactcttt gctgacaggt ttctgtggcc cttctaggct cactcctctg tggaaaaggc

18661 tggtttgatt tcccttgtga agatgaaatt tctgcctgtg gatgacaact tctcactccg

18721 aggggaagct cttcagaagg ccatcgagga agacaagcag cggggcttgg tgcccgtctt

18781 tgtaagtcag gatatatgcc taagcttaga atgatagaac ttggatgtga ggaaggaatt

18841 ttggcagaat tcaggtaagt aacatgctgc acacaaaagc agaaaggtcc tcccatacag

18901 tattttacac atcatgaggt gctatccata ggtgtgttat ggaataaatt ttgtgggtca

18961 taaccagcat taaaaagaaa tatagtataa aatattagag tgcacacata tagccagagt

19021 atgtattgtt ttatgaaact tttttttcaa atacacacgt atacatgtac tagattgtta

19081 tataaaatgt gtttcttacg agccatggta aaacacagtc tgaaatatac actgttctgg

19141 tgggatggat gggagtagat cacgtctgtg gtgaaatctt tctcaggcca aatgtgtcac

19201 acgagcccac cctcctgtgt taacttgcct taattttccc ctaggtctgt gcaacactag

19261 ggaccactgg ggtctgtgca tttgactgcc tgtcagagct gggccccatc tgtaagtatc

19321 ttccctctgt ggctaggaag acaaggaata catttttaaa tgtctcctaa agcaaggacc

19381 tgaaaccagc tctatgggat tattcttgtt cctctttggt caatgcagag acatgggaag

19441 aaccaccaaa ggtcatgagg gtctcttcca gggatccctg gacattgcct ttcccagtgg

19501 tgtgacaaga gttagaggtg gcctaccttg cctcctgtcc taggaggcga cagtaggaga

19561 gccttcggtt ttctcatcct cttacttgta tgttgaactt tacttaatgc aggctatatc

19621 caaaatacag tgtgaattag gctagaatag aaatgctttc tattctacct tcagaaaagg

19681 aaaagggtag ggtaggggaa atcatgggag agattaaagg cagagaggaa acccagatgg

19741 gactgtttaa tccccaagca agaaaccact aggaaagaga gataccttcc ctctaacttt EPI-109 1227

19801 tgtattcggt gcactgacat tgctctctgt gctggtggga aattgatttc tgtgccagga

19861 tgttctaggc tgaggccaag agggtgctgg ccctttaccc agtggaagaa aaaggcaagg

19921 gtgaggcttt gtagactttc ccattcggag gtaatgatgc ctccttcagc cccacttctt

19981 caaactgact ccacctgctc ccatctccac acccctccgt ttctcattta gccaaagcac

20041 atcatccttg cagcccacca ctcagcttgg ccaggtgcga gacatctttc cccacttcat

20101 acctcccctc cggccaggtg atgtttgcct cctcaggtgc ccgtgagggg ctgtggctcc

20161 acatcgatgc tgcttatgca ggcactgcct tcctgtgccc cgagttccgg gggtttctga

20221 aggggattga gtatgccgac tccttcacct ttaatccttc caagtggatg atggtgcatt

20281 ttgactgtac tgggttctgg tgagtgtagc agcccagctc cgagcacgca ggaacgcctt

20341 gcctcctctg gagagacctc agccactaat gcccatttgg aaacccacag ggtcaaggac

20401 aagtacaagc tgcagcagac cttcagtgtg aatcccatct acctcaggca tgccaactca

20461 ggcgtggcca ccgacttcat ggtgagtggc cagggacggg cagcctggtg ggctcgggtg

20521 gccagtggga actgtaggcg tctgaccccc caaaatctgt acggtggctc ccttcagaag

20581 gcagcacact atgagctcat ctcataatac tgccaatgca taccttggtt tctaattgtg

20641 cctaagtata tagaatgaaa cccagaaaat ggttaaaaac cctagaaaat gagaccagcc

20701 tttgaggcag tgtgcacatt tcctgaatat ttgtggcatt ttttaattcc cagaaatgct

20761 cttcctacca caggtggacc agttccttct gcctccatct cgggtcatct tttttgtttc

20821 ttacccagca gcagggcagg gtggagaatt tccctggtgg ggaaagagct ttcttgctga

20881 aatcgctttt gtttttttgt ccctgacaga ggcgctgtgg ggcagctctg tggtagtgat

20941 gggctgcagg acttgtgtga ggttctggaa gcctccaagc attcctgact ttcccaactg

21001 actgcgcctc aactctctaa ctcactctct ctctcttttc ttttgttttc tttctttctt

21061 tctttctttt tttttttctg agacagagtc tcgctctgtc aaccaggctg gagagcagtg

21121 gcgcatcttg gctcactgca acctccgcct tccaggttca agcgattctc ctgcctcagc

21181 tttccaagta tctgggacta caggcgtgag ccaccgcgcc cagcaaacct caactctctt

21241 gattccacat cctcagccag tattttgcct gagggaaacg agttcttaac aaattgactc

21301 cgcagtttga ggatgagccc ttcctttact tgtaggggag acagggatgt aaacgaatgt

21361 attacacata acctggccaa cggaggcagc agagcagagt gggggcaagc ttggtttgga

21421 attccattcc agcagtggcc ctttgggaaa ctaactggac ctctctgagc cttgctttcc

21481 ttatctgtaa aatgagaata gtggcattga ttcatagggt attgtgaagc ttaaatggga

21541 acacgtgtgg atcacctagc aaaatagccg tgtggcaagt gctcaatata tggtaggcat

21601 agtatttctg aaagctcttc tttgaagctg cagagatttg ttaggacagt ggttaggcat

21661 gtaggtgcta aagccagatg gcatgtgttg gagtcctggc tttctgttta ctaacttgtg

21721 tgacctcggg caagtgactt aaactctgtg tccagatttc ctcttgtgtc aaatgaggct

21781 gatgaccaca gttctggctt cttaggcttg ctgtgaggat tatacaaatt aatacactga

21841 agtgctgaga gcagtgtctg acccctgtaa gcatccttcc ttgtgaagag atggttttat

21901 cttatcttct tggacaactg aagtgtcttg cccttttagt cttaaaataa tagcttcgtc

21961 atcacttgat tatactggct attctccctt ggaccagtcc acaccctctt tagatatttg

22021 aagcttttgg attagaattg cagcggtaag cctcacggct tactggtggt gacagaagac

22081 cctctagagg taaagaaaga aagaaaaata atggttcttt atctccactg ctctttctgg

22141 taggttttca gagattttta atgaaaaatt aaaaaaatta cagaacagcc caagggtcag

22201 atatctttag ggataactgt aggtttgctt cctgagtgtg aattgatgcc cattctccta

22261 tgagtgtatt tgggtcatca taactgagga gcattatatt cacccttgcc cttttgaatt

22321 tcatgttacc gtttaaattc atttaccaca gtgcctcagg atcttcccgg ggttcattcc

22381 taggagtttg gagattttac agtgctctct gtcttccaga taactcataa aaatgttaga

22441 gtaaactctt cccagccctg ctctggggaa ccttattatt tttacctctc cacccagaag

22501 gcactgcctt acacttaccc ttcccccacc tttaatccta tggatttgat tttcaagtcc

22561 atgaagaaac tcctagaaaa gtgaagttgc tatctttttc atgatcctga gggtcctcag

22621 agctactctc acctgggccc aatgtctttc ccacccaggt ggctgcagct ttgaacagaa

22681 gctcagtcct gctctgagat gagccagaaa cagggcagca tcccaggaga gaagacttag

22741 gtgcttaacc cctggggtcc tggaatcacc taaaatcagg gctagattct ctgacagcgg

22801 agaagctccc tgttttctgc ctctcactgg acagagagca ccagtggagg gagcgttacc

22861 ttagccttgg caagggagcc ctgcaaggac cttacaagga cacagaggag gctggagatg

22921 cctcaaggta aagaagagcc ctgtcaggct ttatacgtcc agattttttg atccaacaga

22981 aaatgttggc tagaaccact ctgctgagtc agcatggatc agttttggaa tagtgacaag

23041 aaaaggagca actgggaata aggaagattg tgaagaaatc aaaataaaat cacctctgcc

23101 tatcctggtt tatttgctgg taaaataaag tagctctctc tatatatgaa ataaattggc

23161 tataactatc tggaaaccag aaccttttga cagatgatcc ctatcatccg ttcattattc

23221 tcttggagtg tccattggac aagaggtgga gttgacactt tccttgttac agcaattttg

23281 ttccattttc aggttttgat gccttctgct ggcacaaaag cccccaagct gctccccagc

23341 acaacagagt tttgcttgga aatcaaaggc ttagtagttt tctgctgggg aaacattgtc

23401 catcaacaaa ggggtaacat cccaactgtg cctggctcag gaaactgggg tgaagggtga

23461 aggtgaggac atttgtgagg atttgataat cttgtgtatg ggcagataaa tacgcagtgg

23521 gacaaacatt tatttttagt caacagaaat tgtggtagaa actttctgac gtttgaggga

23581 gatgtcatta ggaaaccacg tgactcatta gaataactgt aaatgttttc caaatcctct

23641 gctctatttt cagatctgag aaatcagtct gaaattgatt tggaaatttt cagatgtatg

23701 gtgactgcaa ccttgaactt taagctctgt tgaatttggc caccaggagc aaagagtcaa

23761 ttttcatcta acagcggcag aaatttgggt gctcatttga aatctgacag ctggagtgat

23821 ggctctcaga tcacaggaat ctcacaggaa aatgaacaag gcagtgtaag gttaaatagg EPI-109 1228

23881 ggtcatcttg gctctagaca gaaatgctac tgtgatttgt agctcacatt ttaaaataat

23941 ctaaatagcc aacacctact gacaacttct tctgaggctc ttggcgttct ttgtcctcac

24001 accacttgcc cgggaggtgc aattggttct ttatgtcccg gactgatgag ccagtgaggt

24061 ggcactaccc aaggtcacac agctagtaag tggcacagct ggaggcgaaa cctaggtctg

24121 cagggctcta gtgtctgtgc tctaactacc atactttaca ttttgggagg aataaaaata

24181 gaactttatt ttctgctatt caaggaatat agattcattt agagtaaaaa tgtatttccc

24241 ttatgttgag tttctgggcc gggatgaaat gtttaaagca gcacttgaaa gcaaagtgcc

24301 cttctcattg gttcagggta atggacttga cttccacttg tctggctctc agacaagtga

24361 ctattggcca ccttcatcag tgatttggtc acacgatggg gcaacccttg gggagcttgg

24421 cttactcctt agcaacagct cccagagtca tggtgacatc gtccatccct ggagggctgg

24481 gcaggcaaca gataatgccc agaaatgccc gagggagtgg ggcacccttg tctctaacct

24541 tgggcactgt gttcctttgt ttctagcact ggcagatccc cctgagccga cggtttcgct

24601 ctgttaaact ctggttcgtg attcggtcct tcggggtgaa gaatcttcaa gcacatgtca

24661 gacatgtatg tagcatgctg ctgtgggggc tgagcctgtg ttcctctgtt ttctcatggc

24721 gaggaaggct ggtttctact ttgcagatct gcctaggaga cttgcggtgt gtggttcagg

24781 tgtctgggcc tgttcctcag ctcctgggac ttgattctct ttgttaacca gaggagcgct

24841 gagcacaaca tgccctgagg gctgcctgat gcctgtcctc tgctgagtgt ctcaccgttc

24901 cccttgctgt cactgagcac tggggagggt tggccccaga gtctggtttg caggaaagag

24961 aaagagaaag taaatcaagg ggaagtgtgt gtggccaggg taggatccta tctgctttgg

25021 aattacctca atggtcacag ctggctgaat acttttagca ctattatgat tatgcctgaa

25081 ataaagctcc cctggccttg gacaggtaga cctaccaagt ctggaacaaa cctccctgca

25141 tcaacaggca tttattgaag gcctattttg cttaatttat ttctattcaa ttcaacaatt

25201 acaaggtatt gtgctaagaa agggacacag aggtaaatga gacaggtgca gcctctctcc

25261 catgttcttc atggaagaag cgggacttaa ctaagaactc tggccactgg cattgttctc

25321 ccacttctac aagagtccac atgcaagaca aagccattga taaaagtagt gggggaagct

25381 gaagacactg tcctttctgc ctatgtgtgt ctttgtcctt ccacctttcc tctagggaat

25441 tccttcttgg ttaaacaaac acaaaccaaa atgaagtggt ggaagcggta actatgattt

25501 tttttaacat ttaaaaaaaa taattattat gcttacataa taattacgta tatatttatg

25561 gggtatgtgt gaggttttga tacaggcata caatgtgcaa tgatcaaatt agggtaactg

25621 ggtatccacc actcaaccat ttatcatttc tttgtgttag aaacattcta gttccattct

25681 ttaagttagt ttgaaatgta cagcaaatta tagttaacta tagttgcctt attgtgccgc

25741 ctaacattag atctatttaa ttgtattttt gcgcccgtta actatcacct ctttatcccc

25801 cattccctgc tacccttccc agcctctgcc aaccatcatt ctactgtgcg tctccacgag

25861 ctcagtttgc ttacttttta actcccacgt ttgagtgaga acatgtgaaa tttgtccttc

25921 tgtgcctggc ttattttgct taacataatg ttctccagtt tcctatgact ggttttaatg

25981 ttggtaattt tacctttgta atcaccactg gttgtttacc aatgagcagc tgccaccaac

26041 aatattgagg aactttaggc actttgtgct gtttctagaa atgcagactc aagactggag

26101 ggttgtgggc ggggaatggt tggtggaggt tacaagtaat taggaacatt tttttgctta

26161 cagtttggga ctggatattc aatgtgcaga tcctgactaa cctcccttag cacttctgtt

26221 tgcaaatcaa acccctgaat tcctcctatt agcaacccca ttgcctacca tatgaggccc

26281 acactcctgg gcctggcttt caaggacttg acgattagct cctaccttag cttgggcatt

26341 tcatcgaccc atccagacct catgctcagt ccatctctgc accttcaccc gtgtccttca

26401 cctgaactac cctctcctct ccaaatgttg tgaatggatt aaattctgct tccactagaa

26461 gcttttctgc ctattccatc tgttctggtt tctgcttcat tagcattcct gtgatcacct

26521 actcaaacac ctttacaaaa ctgtgctcaa agttcttcca atgtcccaca atagaagaaa

26581 tggaattaaa ataaagttgt ttgatatgat ttgattttat ctcttcaact tgacggtgat

26641 gataattatt gacacttgcg taatgccttc aatacaaaaa taaattctag ttcttcatta

26701 gatccttagc acagtgcctg gggtggtcac tctaacctgg caaggctcag agggagtaat

26761 tgccctgctt gagggaagaa ggcccgggac tttccctgaa gcctcccaat tccaaatcct

26821 ttcttcatag ttctgggctg ctttctacta cactgagctc ttggaaagtt atataaaatt

26881 aaatttcata tttctgtgtt acagagaagt gctttaaaga atggattttt agttctaccc

26941 tttacctgtt tgatgacctt agacaaatta cttaaccttt ctatatttgt ctgccttatt

27001 tatttattgt tatttatttt tgagatgcag gtctctgctt gctcaggctg aagtgcggta

27061 gtgccatcag agctcactgc agccttgacc tccccaggct caggtgatcc tcccacctca

27121 gcctcctgag tagctgggac tacaggcgca taccatcatg cctggctact ttttgtattt

27181 tttgtagaga tggggttttg tcatgttgcc caggttgttc tcacgctcct gggctcaagc

27241 aatctgccta ccttggcctc ccaaagtgcg aggattacag gcatgagcca ccacccctgg

27301 ccatgccttc ctaatttata aaaatgagaa aaggatacta cctctctcaa attaaatgag

27361 ataatatata tgcagccctt agcacagggt ctacctacta ctcagttaag tactcaatga

27421 gtacctcttc ctcttctctt cttccccttc ttcatcatct ccttcttcat ctaattataa

27481 taaattgtca tcatcatcac catcatcatc atcatcatcc tcatctccta tcacctacaa

27541 tagggattgg taaacatttc ctgtaaaaag ccagatacta aatacttttg gctttgtggg

27601 ccatactcta ttgtaattac ctctgtacta caagagctac cgtagacaat atgtaaacaa

27661 atgggaatgc tgtgttccaa aaaactttac aaacacaggt gggggctata tttggccatg

27721 gctgcactgt gcctgccctt gacctagagc ggtgcagggc actggcagca gctctgcttt

27781 catgacctgt aaagtggggc tttggaggtg gcagtgctgc ctgtgctctg tattctcctc

27841 tcccctgacc tctgcttctg ttattgcaaa cagcatgtgt tgtaggaggg ataaaagcac

27901 agtgggagga gatctaccta ctgtcacttg taccttggga aagtcacttt cccttggttc EPI-109 1229

27961 cttctaaaaa atggaaagat tgagctgggc acaggggcac gtgtctgtag tcccagctac

28021 ttgggaggct gaggtgggaa gctcaattgc tcccaccata gcccaggtgg gagttctggg

28081 ctatggtgtg ctatgccaat tgagtgtccg cactaagttc ggcatcaata tggtgacctc

28141 ccaggagcaa gggatcacca ggttgcctaa ggaggggtga aggggcccag gttagaaatg

28201 gagcaggtca aaactcctgt gctgtttgaa actgaccacg caggggagaa aggggctctg

28261 agaaagattt ggagaaactc atttcattat ggtcaaaaga caggctcagg gccagacatg

28321 gtggctcatg ccagtaatcc cagtactttg ggaggcctag gaaggaggat cgcttaagcc

28381 caggagtttg ataccagggt gaacaaccta gtgagaccac tgtctttaca aaaaaattaa

28441 aaaatgtagc tgggcatggt ggtgcatgtc tgtagtccta gctactcagg aggtgaaggt

28501 gggaggatta cttgagctca ggagttcaag gctgcagtga gctttgattg tgcaacatgc

28561 ctctgtactc tagcctgtgt gacaaagcaa gaccctatct ctcaaaaaaa aaaaaaaaaa

28621 aaaaaaaaag aggttcagct aactcccttg ccctctcttg aaatagagca gtaagtatga

28681 gaactaactg atagaattac ttagcaaata tttttattga gatcttctgg atgcttggag

28741 aaatttttaa aaagaaaaga gaaggcaagt cctgtccttg tttagttagt aatcctgggt

28801 taaaaacaaa aagcaaaaaa ccccaggaca tttaaaaaga tggtatgaac ttcagtggaa

28861 gattaatata atacaaagcc tttaacattt taaaatgtaa caaaatattc ataccataga

28921 atgtaccatt ttactcattt ttaagtgtac aattcagtgg cattaagaat actcacaatg

28981 tggtgtgacc atcaccatta tttccagaat tttttcatca tcccgagcag aaactctgta

29041 tccattaacc aggtccaaaa cctttccatg atgggtggag acaagatgtg aaaatatgtt

29101 ctctatggaa tgtcagaaac aggggatgaa aagggcattt ggggtacagg gtgagaagag

29161 gtttgagagg caagtgaagc atgtaggctt aggatggggc agggccgcca ctagcccata

29221 tggcaacttg atgtgcacta caaacaggca tctcttcctt taggcacacg cagctcgcat

29281 gaggcacctg gctgggaacg cagagcatgg actgggtttt ggccctcact tgcccacttg

29341 gccagtcaag gagctgtgaa atcaggagtt gaggccgggt tgcctggact gcaaagcaca

29401 tgccttctgg gttctggggc tgagttgaaa gagggccctg agatgagttc tcgaggtgga

29461 tcccatgtga caggaaacag ggcgccattg gaaattttcc agcttggaat atgagcaaaa

29521 tcaaatggag atgacaatga ggcagaagcc gcttacaacg gctgtgacgg gaagatggcc

29581 ctggtttaaa accatttagc agtctgaaag tttatgcata gtctcttgtc tgatgattaa

29641 tctcagttct ctttatactt gcaattccag ggtactgaaa tggctaaata ttttgaatct

29701 ctggtcagaa acgacccttc ctttgaaatt cctgccaaga ggcaccttgg cctggtggtt

29761 tttcgtctaa aggtaatacc atcttccaag cccctctgtg aatgatgtct tgtggtgctc

29821 cagagcctct cggaaacaca aactgggctc tggggatgct gacagggggt gcgatggaga

29881 cttcacttcc tttatttttc aaacagggtc ctaattgtct cacagaaaat gtgttaaagg

29941 aaatagctaa agctggccgt ctcttcctca tcccggccac tatccaggac aagttaatca

30001 tccgtttcac tgtgacatcc cagtttacca ctagggatga catcctgaga gactggaatc

30061 tcattcgaga tgctgccact ctcatcctga gtcagcactg tacttcccaa cccagccctc

30121 gggttgggaa cctcatctcc caaatcaggg gtgccagagc ctgggcctgt ggaacgtccc

30181 ttcagtctgt cagtggggca ggagatgatc cagtccaggc caggaagatc atcaagcagc

30241 ctcagcgtgt gggagccggt cccatgaaaa gggaaaatgg cctccatctt gaaaccctgc

30301 tggacccagt tgatgactgc ttttcagaag aggccccaga tgccaccaag cacaagctgt

30361 cctccttcct gttcagttac ttgtctgtgc agactaagaa gaagacggtg cgctccctca

30421 gttgcaacag tgtgccagtg agtgctcaga agccactgcc cacagaggcc tctgtgaaga

30481 atgggggctc ctccagggtc agaatctttt ccaggtttcc agaagacatg atgatgctga

30541 agaaaagtgc cttcaaaaaa ctcatcaaat tctacagcgt ccccagcttt cctgaatgca

30601 gctctcaatg tggactccag ctgccctgtt gccctctgca ggccatggtt tagacacagg

30661 gccttcagcc agagtctgag gatatacttc agggactctg tgaacccctc acaattgtat

30721 gccaactttg tgtgcttatg tgtacatgca tttttcttgg ggcgagttca taattttaat

30781 caaattctca taggggcttc atgacccaca ataggataca aacgaagagt ttaagccagc

30841 atgatccaga tgggttcagc agtctggtca gtgagaaagg gccgagggta gacaggcagc

30901 ttctgtggtt cagcttgtga catgatatat aacacagaaa taaattatgc ttgtccctga

30961 aacaaaacat accctgtgtc acttaattgg ctgctgaaac attgattaac cagtctggga

31021 gcttaaacat atgtactttt tttgaagcat caattatgag tcaggcactg tggctcatgg

31081 ttcataaatg aggaaaccaa cgtttaggtc acacagcttt aaataggcaa acccaggtct

31141 cctgcttcca gtgaagccca ggctgtttcc accatgcagt actgctcaag gttggacctg

31201 aacaggagct cacagcccag caggctgctg gtcctccagt acatttaaat gtttcctttc

31261 taggtttgga acttgtgcat tttcccctta ttttcctgga cccggtagtc aaataaaagc

31321 tatgctcaca agtggcttgc ccataattag ttcagaggcc aaacacataa ttttatttcc

31381 atttcagatg gtactttgat aggttgtgac tctgaaatgg gttatgtaaa gagtattaaa

31441 gacaaacaaa gctgggcatt agttagaact ttaaggatag atgttaaaca gtaatatact

31501 atcacaatag ggaaaagggt cccatgtgaa ctgaactcaa cttggatttg tgcaaaggtg

31561 actaggcatt tcacagcgtg aatgggagaa tagggagaag gccagcctag acttagaaga

31621 gtcaggaatg tgaaaaatta caaaaagcgg aaagtggttg atgtgaaacc cctctgggtt

31681 tgctaactgg tgctttttga agtaagactc ttaccctccc acagagactg ggagtcaggg

31741 ccctgtgttc aggggttcgc tggaacaaac agttaattct ttcggcagct ttgagttttc

31801 ttaagcaggc actttaaggt gagctaggat caacttaggg atgtggcctt gagctgtgag

31861 aaactgtgtt agtgtttgtt caagtcttta taggcaaagg ttgaggccta gttgagaagg

31921 gggctcggag gagcttagct agagtttggt cgagaaaaga atctttgtta agagtttaaa

31981 gctttttttt tttttttttt tttttttttt ttgagactag tgctttctct ctttcccagg EPI-109 1230

32041 ctggagtgca gaggcacaa catgtcttac tgcagcatca acttcctggg cttgagcaat 32101 cctcctgctt cagcctccca agtagctatt tatttttgag atggggtctc attctgtgag 32161 tgcagtggtt ggaacacagt :actgcagc ctcagcctct gaggctcaag ctgtctttcc 32221 acctcagtcc cacgagtagc tgggactatg agtgcacacc actatgcctg gctaattttt

32281 ataacttttt acagagacag ggtctccctg tgttgcccag gctggtctgg aactcctggg

32341 ctcaggtgat c

1 cgactaagaa gccctgttga cagctgcctt ccagcctcct ctgtctgtct gccaggagga

61 gcaatccaag ggagatgatg gagccctgtg aataccgtga ataccgtgaa tactaccgag 121 ctagagggaa agagatggtg gattacatct cccagtacct gagcactgtg cgggagaggc 181 aggtgactcc aaatgtgcag cctggatacc tgcgagccca gctacctgcg agtgctcccg 241 aggaacccga cagctgggac agcatctttg gggacattga acgagtcatc atgcctgggg 301 tggttcactg gcagagcccc cacatgcacg cctactatcc tgctcttacc tcatggccat

361 ccctgctagg agacatgctg gccgatgcca ttaactgctt aggattcacg tgggcatcta 421 gcccagcttg cacagagctg gagatgaaca :catggactg gctggcgaag atgctggggc 481 tcccggagta cttcctgcac caccatccca gcagccgagg gggaggtgtc ttacagagca

541 ctgtcagcga atccacttta attgccctgc tggcagcaag aaagaacaaa atcctagcaa

601 tgacagcgtg cgagcccgat gctaacgagt cctccctgaa cgctcgtctc gttgcctaca

661 cctctgatca ggctcactct tcagtggaga aggctggctt gatttccctt gtgaagatca

721 gatttctacc tgtggacgac aacttctcac tccgaggaga agctctccag aaagctattg

781 aggaagacaa gcaacagggc ttggtgcctg tgtttgtctg tgcaacgtta gggactactg

841 gagtctgtgc atttgacagg ctgtcagaac tggggcccat ctgtgccagt gagggactgt

901 ggctccacgt cgatgctgct tatgcaggca cggcctttct gtgccctgag ctccgagggt

961 tcctggaggg catcgagtac gccgactcct tcacctttaa cccttccaag tggatgatgg

1021 tacactttga ctgtactgga ttctgggtca aggacaagta caagctgcag cagaccttta

1081 gtgtgaaccc catctacctc cgacatgcca actctggtgc agccacggac ttcatgcatt

1141 ggcagatccc cttgagccgg cgctttcgct ccattaagct gtggtttgtg attcggtcct

1201 tcggggtgaa gaatcttcaa gcacatgtca gacacggcac agaaatggct aaatactttg

1261 aatctctggt cagaagcgac ccttccttcg aaattcctgc taagaggcac cttggtttgg

1321 tggttttccg tctgaagggt cctaattgtc tcacagaaag tgtgttaaag gaaatagcca

1381 aagctggcca gctctttctc atcccggcta ctatccaaga caagctgatc atccgtttca

1441 ctgtgacgtc ccagtttacc accaaggagg acatcctgag agattggcac ctcatccaag

1501 aggctgctaa ccttgtcctg agccagcact gcacttccca gccgagccct cgggccaaga

1561 acgtcatccc gccaccgcca gggaccagag ggctatccct ggagtcagtc agcgagggag

1621 gagatgaccc agcacaggcc cggaagatca tcaagcagcc aggagccagt ctggcgagaa

1681 gggaaggcgg ctctgatctg gaaacgatgc cggatccctt tgatgattgc ttctctgaag

1741 aggcccccaa caccaccaag cacaagctgt catcctttct gttcagttac ttgtcggtcc

1801 agaacaggag gaagacaacg cggtccctca gctgcaacag tgtgcctatg agtgcccaga

1861 agtcactccc cgcagacgct tcactgaaga atgggggctc cttccgggcc agaatctttt

1921 ccgggttccc agaacaaatg atgatgatga agaaaggtgc cttcaaaaag ctgatcaagt

1981 tctacagcgt ccccagcttt cctgaatgca gttctcagtg tgctcgccag ctaccgtgct

2041 gccccctgga ggccatggtg tagagtcctc aatcagaatg caagggtgcc tgtgcttcag

2101 ggagttgggg aaccctcgaa attgcctgca gtttgtgtgc ttattatgtg tgtgtgcatc

2161 ttgagggaag caagcccatt attttgatca taacctcaca gggtcttcgt gatccacaac

2221 agattgtaac tgggaagttt aagcgggcat gctccagagg ttgcaggcgc ttgtgtgata

2281 gaaggggctg agacggtggc atgctgttaa gcttgtaatg tgaaaaacaa cttagaaata

2341 aattgtgctt atatctaaaa aaaaaaaaaa a

1 cttccacctc ctgcgtgtcc atctgtgaga aggagccaga gcccaaggga gatgatggag

61 cctgaggagt acagagagag agggagagag atggtggatt acatctgcca gtacctgagc

121 actgtgcggg agagacgtgt gacgccagac gtgcagcctg gctacctgcg agcccagctg

181 cctgagagtg ctcctgagga ccccgacagc tgggacagca tctttgggga cattgaacga

241 atcatcatgc ctggggtggt acattggcag agcccccata tgcacgccta ctacccagcc

301 ctcacctctt ggccctccct gctaggagac atgctggctg atgccatcaa ctgcttggga

361 ttcacctggg catccagccc tgcgtgtaca gagctggaga tgaacgtcat ggactggttg

421 gcaaaaatgc tgggacttcc agagcacttc ttgcaccacc accccagcag ccagggcgga

481 ggcgtcctgc agagcacggt cagtgaatcc actttgattg ccctgctggc agcaaggaag

541 aacaaaatcc tggaaatgaa aacgtctgag cccgatgctg atgagtcctg cctaaatgcc

601 cgactcgtgg cctatgcctc tgaccaggct cactcctctg tggaaaaggc tggtttgatt

661 tcccttgtga agatgaaatt tctgcctgtg gatgacaact tctcactccg aggggaagct

721 cttcagaagg ccatcgagga agacaagcag cggggcttgg tgcccgtctt tgtctgtgca

781 acactaggga ccactggggt ctgtgcattt gactgcctgt cagagctggg ccccatctgt

841 gcccgtgagg ggctgtggct ccacatcgat gctgcttatg caggcactgc cttcctgtgc

901 cccgagttcc gggggtttct gaaggggatt gagtatgccg actccttcac ctttaatcct

961 tccaagtgga tgatggtgca ttttgactgt actgggttct gggtcaagga caagtacaag

1021 ctgcagcaga ccttcagtgt gaatcccatc tacctcaggc atgccaactc aggcgtggcc

1081 accgacttca tgcactggca gatccccctg agccgacggt ttcgctctgt taaactctgg

1141 ttcgtgattc ggtccttcgg ggtgaagaat cttcaagcac atgtcagaca tggtactgaa

1201 atggctaaat attttgaatc tctggtcaga aacgaccctt cctttgaaat tcctgccaag

1261 aggcaccttg gcctggtggt ttttcgtcta aagggtccta attgtctcac agaaaatgtg EPI-109 1231

1321 ttaaaggaaa tagctaaagc :ggccgtctc ttcctcatcc cggccactat ccaggacaag 1381 ttaatcatcc gtttcactgt gacatcccag tttaccacta gggatgacat cctgagagac

1441 tggaatctca ttcgagatgc tgccactctc atcctgagtc agcactgtac ttcccaaccc 1501 agccctcggg ttgggaacct catctcccaa atcaggggtg ccagagcctg ggcctgtgga 1561 acgtcccttc agtctgtcag tggggcagga gatgatccag tccaggccag gaagatcatc 1621 aagcagcctc agcgtgtggg agccggtccc atgaaaaggg aaaatggcct ccatcttgaa 1681 accctgctgg acccagttga tgactgcttt tcagaagagg ccccagatgc caccaagcac 1741 aagctgtcct ccttcctgtt cagttacttg tctgtgcaga ctaagaagaa gacggtgcgc 1801 tccctcagtt gcaacagtgt gccagtgagt gctcagaagc cactgcccac agaggcctct 1861 gtgaagaatg ggggctcctc cagggtcaga atcttttcca ggtttccaga agacatgatg 1921 atgctgaaga aaagtgcctt caaaaaactc atcaaattct acagcgtccc cagctttcct 1981 gaatgcagct ctcaatgtgg actccagctg ccctgttgcc ctctgcaggc catggtttag 2041 acacagggcc ttcagccaga gtctgaggat atacttcagg gactctgtga acccctcaca 2101 attgtatgcc aactttgtgt gcttatgtgt acatgcattt ttcttggggc gagttcataa 2161 ttttaatcaa attctcatag gggttcatga cccacaatag gatacaaacg aagagtttaa 2221 gccagcatga tccagatggg ttcagcagtc tggtcagtga gaaagggccg agggtagaca 2281 ggcagcttct gtggttcagc ttgtgacatg atatataaca cagaaataaa ttatgcttgt 2341 ccctgaaaca aaaaa

1 agtgcgcagg actggcaaga gggaagccgg gctgctccac gcctttcacg ccttccacct

61 cctgcgtgtc catctgtgag aaggagccag agcccaaggg agatgatgga gcctgaggag

121 tacagagaga gagggagaga gatggtggat tacatctgcc agtacctgag cactgtgcgg

181 gagagacgtg tgacgccaga cgtgcagcct ggctacctgc gagcccagct gcctgagagt

241 gctcctgagg accccgacag ctgggacagc atctttgggg acattgaacg aatcatcatg

301 cctggggtgg tacattggca gagcccccat atgcacgcct actacccagc cctcacctct

361 tggccctccc tgctaggaga catgctggct gatgccatca actgcttggg attcacctgg

421 gcatccagcc ctgcgtgtac agagctggag atgaacgtca tggactggtt ggcaaaaatg

481 ctgggacttc cagagcactt cttgcaccac caccccagca gccagggcgg aggcgtcctg

541 cagcagacgg tcagtgaatc cactttgatt gccctgctgg cagcaaggaa gaacaaaatc

601 ctggaaatga aaacgtctga gcccgatgct gatgagtcct gcctaaatgc ccgactcgtg

661 gcctatgcct ctgaccaggc tcactcctct gtggaaaagg ctggtttgat ttcccttgtg

721 aagatgaaat ttctgcctgt ggatgacaac ttctcactcc gaggggaagc tcttcagaag

781 gccatcgagg aagacaagca gcggggcttg gtgcccgtct ttgtctgtgc aacactaggg

841 accactgggg tctgtgcatt tgactgcctg tcagagctgg gccccatctg tgcccgtgag

901 gggctgtggc tccacatcga tgctgcttat gcaggcactg ccttcctgtg ccccgagttc

961 cgggggtttc tgaaggggat tgagtatgcc gactccttca cctttaatcc ttccaagtgg

1021 atgatggtgc attttgactg tactgggttc tgggtcaagg acaagtacaa gctgcagcag

1081 accttcagtg tgaatcccat ctacctcagg catgccaact caggcgtggc caccgacttc

1141 atgcactggc agatccccct gagccgacgg tttcgctctg ttaaactctg gttcgtgatt

1201 cggtccttcg gggtgaagaa tcttcaagca catgtcagac atggtactga aatggctaaa

1261 tattttgaat ctctggtcag aaacgaccct tcctttgaaa ttcctgccaa gaggcacctt

1321 ggcctggtgg tttttcgtct aaagggtcct aattgtctca cagaaaatgt gttaaaggaa

1381 atagctaaag ctggccgtct cttcctcatc ccggccacta tccaggacaa gttaatcatc

1441 cgtttcactg tgacatccca gtttaccact agggatgaca tcctgagaga ctggaatctc

1501' attcgagatg ctgccactct catcctgagt cagcactgta cttcccaacc cagccctcgg

1561 gttgggaacc tcatctccca aatcaggggt gccagagcct gggcctgtgg aacgtccctt

1621 cagtctgtca gtggggcagg agatgatcca gtccaggcca ggaagatcat caagcagcct

1681 cagcgtgtgg gagccggtcc catgaaaagg gaaaatggcc tccatcttga aaccctgctg

1741 gacccagttg atgactgctt ttcagaagag gccccagatg ccaccaagca caagctgtcc

1801 tccttcctgt tcagttactt gtctgtgcag actaagaaga agacggtgcg ctccctcagt

1861 tgcaacagtg tgccagtgag tgctcagaag ccactgccca cagaggcctc tgtgaagaat

1921 gggggctcct ccagggtcag aatcttttcc aggtttccag aagacatgat gatgctgaag

1981 aaaagtgcct tcaaaaaact catcaaattc tacagcgtcc ccagctttcc tgaatgcagc

2041 tctcaatgtg gactccagct gccctgttgc cctctgcagg ccatggttta gacacagggc

2101 cttcagcaga gtctgaggat atacttcagg gactctgtga acccctcaca attgtatgcc

2161 aactttgtgt gcttatgtgt acatgcattt ttcttggggc gagttcataa ttttaatcaa

2221 attctcatag gggctcatga cccacaatag gatacaaacg aagagtttaa gccagcatga

2281 tccagatggg ttcatcagtc tggtcagtga gaaagggccg agggtagaca ggcagcttct

2341 gtggttcagc ttgtgacatg atatataaca cagaaataaa ttatgcttgt ccctga

(2) INFORMATION FOR SEQ ID NO: 64: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1327 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 64: gatccccaga gactttccag atatctgaag aagtcctgat gtcactgccc cggtccttcc

61 ccaggtagag caacactcct cgtcgcaacc caactggctc cccttacctt ctacacacac 121 acacacacac acacacacac acacacacac acacacaaat ccaagacaac actactaagg EPI-109 1232

181 cttctttggg agggggaagt agggataggt aagaggaaag taagggacct cctatccagc

241 ctccatggaa tcctgacttc ttttccttgt tatttcaact tcttccaccc catcttttaa

301 actttagact ccagccacag aagcttacaa ctaaaagaaa ctctaaggcc aatttaatcc

361 aaggtttcat tctatgtgct ggagatggtg tacagtaggg tgaggaaacc aaattctcag

421 ttggcactgg tgtacccttg tacaggtgat gtaacatctc tgtgcctcag tttgctcact

481 ataaaataga gacggtaggg gtcatggtga gcactacctg actagcatat aagaagcttt

541 cagcaagtgc agactactct tacccacttc ccccaagcac agttggggtg ggggacagct

601 gaagaggtgg aaacatgtgc ctgagaatcc taatgaaatc ggggtaaagg agcctggaac

661 acatcctgtg accccgcctg tcctgtagga agccagtctc tggaaagtaa aatggaaggg

721 ctgcttggga actttgagga tatttagccc accccctcat ttttacttgg ggaaactaag

781 gcccaaagac ctaaggtgac tgcctaagtt agcaaggaga agtcttgggt attcatccca

841 ggttgggggg acccaattat ttctcaatcc cattgtattc tggaatgggc aatttgtcca

901 cgtcactgtg acctaggaac acgcgaatga gaacccacag ctgagggcct ctgcgcacag

961 aacagctgtt ctccccagga aatcaacttt ttttaattga gaagctaaaa aattattcta

1021 agagaggtag cccatcctaa aaatagctgt aatgcagaag ttcatgttca accaatcatt

1081 tttgcttacg atgcaaaaat tgaaaactaa gtttattaga gaggttagag aaggaggagc

1141 tctaagcaga aaaaatcctg tgccgggaaa ccttgattgt ggctttttaa tgaatgaaga

1201 ggcctccctg agcttacaat ataaaagggg gacagagagg tgaaggtcta cacatcaggg

1261 gcttgctctt gcaaaaccaa accacaagac agacttgcaa aagaaggcat gcacagctca

1321 gcactgc

(2) INFORMATION FOR SEQ ID NO: 65: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1601 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 65: 1 aaaccacaag acagacttgc aaaagaaggc atgcacagct cagcactgct ctgttgcctg

61 gtcctcctga ctggggtgag ggccagccca ggccagggca cccagtctga gaacagctgc

121 acccacttcc caggcaacct gcctaacatg cttcgagatc tccgagatgc cttcagcaga

181 gtgaagactt tctttcaaat gaaggatcag ctggacaact tgttgttaaa ggagtccttg

241 ctggaggact ttaagggtta cctgggttgc caagccttgt ctgagatgat ccagttttac

301 ctggaggagg tgatgcccca agctgagaac caagacccag acatcaaggc gcatgtgaac

361 tccctggggg agaacctgaa gaccctcagg ctgaggctac ggcgctgtca tcgatttctt

421 ccctgtgaaa acaagagcaa ggccgtggag caggtgaaga atgcctttaa taagctccaa

481 gagaaaggca tctacaaagc catgagtgag tttgacatct tcatcaacta catagaagcc

541 tacatgacaa tgaagatacg aaactgagac atcagggtgg cgactctata gactctagga

601 cataaattag aggtctccaa aatcggatct ggggctctgg gatagctgac ccagcccctt

661 gagaaacctt attgtacctc tcttatagaa tatttattac ctctgatacc tcaaccccca

721 tttctattta tttactgagc ttctctgtga acgatttaga aagaagccca atattataat

781 ttttttcaat atttattatt ttcacctgtt tttaagctgt ttccataggg tgacacacta

841 tggtatttga gtgttttaag ataaattata agttacataa gggaggaaaa aaaatgttct

901 ttggggagcc aacagaagct tccattccaa gcctgaccac gctttctagc tgttgagctg

961 ttttccctga cctccctcta atttatcttg tctctgggct tggggcttcc taactgctac

1021 aaatactctt aggaagagaa accagggagc ccctttgatg attaattcac cttccagtgt

1081 ctcggaggga ttcccctaac ctcattcccc aaccacttca ttcttgaaag ctgtggccag

1141 cttgttattt ataacaacct aaatttggtt ctaggccggg cgcggtggct cacgcctgta

1201 atcccagcac tttgggaggc tgaggcgggt ggatcacttg aggtcaggag ttcctaacca

1261 gcctggtcaa catggtgaaa ccccgtctct actaaaaata caaaaattag ccgggcatgg

1321 tggcgcgcac ctgtaatccc agctacttgg gaggctgagg caagagaatt gcttgaaccc

1381 aggagatgga agttgcagtg agctgatatc atgcccctgt actccagcct gggtgacaga

1441 gcaagactct gtctcaaaaa aataaaaata aaaataaatt tggttctaat agaactcagt

1501 tttaactaga atttattcaa ttcctctggg aatgttacat tgtttgtctg tcttcatagc

1561 agattttaat tttgaataaa taaatgtatc ttattcacat c

(2) INFORMATION FOR SEQ ID NO: 66: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4181 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 66: agatcttgta aactgtagaa tgcaccctcc aaaatctatt tgcataagca cacacacaca

61 cacacacaca cacaccccag cagttcttgc ctgcccagat tcctctgcag ctaaagtgat

121 gaaacttact gggcggagct tcctaaaaag attattaggg tctcctgggt tggtgtgcct

181 ttaaaccttt ggactttacc acctcctatc tctcctatct ccttgcaaca aaggttagga

241 gaacaagaat gcagaaaaaa cgggtcctgg atgacatctg agtgcctgct ttgggcttct

301 tgatgagtga gacagaaaat aaaatacaac cccctctttt aaaagccatg cttactcagg

361 ttttccttca tttgcagcta aatacagaaa tgagagaata ttttggagca gggatggaag

421 aagagaggta ttccccttcc cacaaccttc tgatttccca gtacatcccc cactggaaaa

481 attcatttaa aatcagtata ataagcattg attagatgcc tactatgcat ctgggcttga

541 gggcaaactg gactcaggcc ttttggcctc aagaagctca cagtgtgaga gtggcatttg

601 tgtcctcttg aaattcacag gactaaattg tgcccaggct gacattctat ccatccatag

661 gtgcctgcct tctcacttcc ctctcttcat gggctcttgc cttgtaccaa aatccaaacc EPI-109 1233 21 caaatctcct cacatgtgag tgttggcatt catgtctcag acatgaccta tgggcttggg

"81 acttttcccc gtggacccca gtgacttttc agatgaacag gtatcttcaa aaacttgaga

841 aataggagtc ctgtttgttg ttcttgttgc tttgtcaata taaggcacag ggtctttatt

901 caaatgttca tactatctct tgacagaaat actatgagac atattgatgg agaagccgtt

961 atctccatat gctaaatgag gacttgcacc agggaacttg cccatggttc tctccaacca

1021 cttaaattct gaaattttga atgagagtgg acagtaattt caaatcaatg gggaaagaat

1081 caaatcttca gcaaatggct tgagataatt agctacacat ttcagaacaa ataaagaagt

1141 cagatccggg ccgggcacag tggctcatgc ctgtaatctc agcactctgg gaggccaagg

1201 cgggcggatc ataaggtcag gagatcgaga ccatcctggt taacacagtg aacccctctc

1261 taataaaaat acaaaaaaaa ataaaaaaac ttagccgggc gtggtgccag gcgcctgtag

1321 tcccagctac tcgggacgct gaggcaggag aatggcttga actcgggagg cagagcttgc

1381 aggtgagctg agatcatgcc actgcactcc agcctgggca acagagcgag actctgtctc

1441 aaaaaaaaaa aagaagtcag atcctaacct caaccctatt taacagatta tagatgaaag

1501 aaaggtacaa atggctttta catacctccc ttctccctga cattttgtat gtgtgtgtgt

1561 gtgtatttac acacacatct catataagga aattgaaggg aggctgcctg catccctgag

1621 tcactctccc tctccttctg aatgcttacc tgtgcccaga ccacctcctt agcctcgcac

1681 cctccaggct tacagggcac tcttctatgc ccatcccaag tatagctgaa ccttccaagg

1741 gccagacttg gtgctaagta ccaagtacgc aaagattaat aaaacaatgt cctgtttcag

1801 ggagctcaaa gctgattcgg cagggcatgg tgtgtacatg aatgataacc acgtagggtt

1861 gcaggtttcc tagtgaggta agcacaaggc aagatgggaa acaaaggaag gaggggttca

1921 cagcctcacc cagagtccag aacccctggc ctgcctggtg cccatgctga gtccacttct

1981 ggaacaccca gctcagagag ggggttagac ctgcaggcta acacagacac agcccagaaa

2041 acccaggagc cgagggggaa ggagaaaggt gcaagaaggg gaaacccagg tcctggtccc

2101 cttctctctg cttcctggca gcagaactca gacagaaccc ttaagccagt ctaagtctgg

2161 caggaccagt aagttctgag ttagctccat actagtttct agcaggctct ttctcacttc

2221 ctgattctta ggtttctaca ttgacactcc ctgaagagtt gggaagagac accacagtcc

2281 cctgaccctg atccataggt cacacagcag gcatccacag ggtgggcgtg ggccctctca

2341 tccctccctc ccactcactt cacgctggct gggccccaag gtgtttgcac cccttgcagt

2401 gagtgacctt ctctagtgca gcaagctcag aacctgctgc cactggagtt gtcccattgc

2461 tgatgcagaa aggtgaagaa ctagcagaac actggaaatg ccctccatct gggtccatgg

2521 ctacttaatg ctccctggca ggcaggagga caggtgctat tccctgttgg gacagatgaa

2581 aaacagacac agggaggatg agtgatttgc cctgactata gagtggcagg gccaaggcag

2641 agcccaggcc tcctgcacct aggtcagtgt tcctcccagt tacagtctaa actggaatgc

2701 aggcaaagcc cctgtggaag gggaaggtga aggctcaatc aaaggatccc cagagacttt

2761 ccagatatct gaagaagtcc tgatgtcact gccccggtcc ttccccaggt agagcaacac

2821 tcctcgccgc aacccaactg gctcccctta ccttctacac acacacacac acacacacac

2881 acacacacac acacacacaa atccaagaca acactactaa ggcttctttg ggaaggggaa

2941 gtagggatag gtaagaggaa agtaagggac ctcctatcca gcctccatgg aatcctgact

3001 tcttttcctt gttatttcaa cttcttccac cccatctttt aaactttaga ctccagccac

3061 agaagcttac aactaaaaga aactctaagg ccaatttaat ccaaggtttc attctatgtg

3121 ctggagatgg tgtacagtag ggtgaggaaa ccaaattctc agttggcact ggtgtaccct

3181 tgtacaggtg atgtaacatc tctgtgcctc agtttgctca ctataaaata gagacggtag

3241 gggtcatggt gagcactacc tgactagcat ataagaagct ttcagcaagt gcagactact

3301 cttacccact tcccccaagc acagttgggg tgggggacag ctgaagaggt ggaaacatgt

3361 gcctgagaat cctaatgaaa tcggggtaaa ggagcctgga acacatcctg tgaccccgcc

3421 tgtcctgtag gaagccagtc tctggaaagt aaaatggaag ggctgcttgg gaactttgag

3481 gatatttagc ccaccccctc atttttactt ggggaaacta aggcccagag acctaaggtg

3541 actgcctaag ttagcaagga gaagtcttgg gtattcatcc caggttgggg ggacccaatt

3601 atttctcaat cccattgtat tctggaatgg gcaatttgtc cacgtcactg tgacctagga

3661 acacgcgaat gagaacccac agctgagggc ctctgcgcac agaacagctg ttctccccag

3721 gaaatcaact ttttttaatt gagaagctaa aaaattattc taagagaggt agcccatcct

3781 aaaaatagct gtaatgcaga agttcatgtt caaccaatca tttttgctta cgatgcaaaa

3841 attgaaaact aagtttatta gagaggttag agaaggagga gctctaagga gaaaaaatcc

3901 tgtgccggga aaccttgatt gtggcttttt aatgaatgaa gaggcctccc tgagcttaca

3961 atataaaagg gggacagaga ggtgaaggtc tacacatcag gggcttgctc ttgcaaaacc

4021 aaaccacaag acagacttgc aaaagaaggc atgcacagct cagcactgct ctgttgcctg

4081 gtcctcctga ctggggtgag ggccagccca ggccagggca cccagtctga gaacagctgc

4141 acccacttcc caggcaacct gcctaacatg cttcgagatc t

(2) INFORMATION FOR SEQ ID NO: 67: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1314 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 67: 1 gggggggggg atttagagac ttgctcttgc actaccaaag ccacaaagca gccttgcaga

61 aaagagagct ccatcatgcc tggctcagca ctgctatgct gcctgctctt actgactggc

121 atgaggatca gcaggggcca gtacagccgg gaagacaata actgcaccca cttcccagtc

181 ggccagagcc acatgctcct agagctgcgg actgccttca gccaggtgaa gactttcttt

241 caaacaaagg accagctgga caacatactg ctaaccgact ccttaatgca ggactttaag

301 ggttacttgg gttgccaagc cttatcggaa atgatccagt tttacctggt agaagtgatg

361 ccccaggcag agaagcatgg cccagaaatc aaggagcatt tgaattccct gggtgagaag

421 ctgaagaccc tcaggatgcg gctgaggcgc tgtcatcgat ttctcccctg tgaaaataag

481 agcaaggcag tggagcaggt gaagagtgat tttaataagc tccaagacca aggtgtctac EPI-109 1234

541 aaggccatga atgaatttga catcttcatc aactgcatag aagcatacat gatgatcaaa

601 atgaaaagct aaaacacctg cagtgtgtat tgagtctgct ggactccagg acctagacag

661 agctctctaa atctgatcca gggatcttag ctaacggaaa caactccttg gaaaacctcg

721 tttgtacctc tctccgaaat atttattacc tctgatacct cagttcccat tctatttatt

781 cactgagctt ctctgtgaac tatttagaaa gaagcccaat attataattt tacagtattt

841 attattttta acctgtgttt aagctgtttc cattggggac actttatagt atttaaaggg

901 agattatatt atatgatggg aggggttctt ccttgggaag caattgaagc ttctattcta

961 aggctggcca cacttgagag ctgcagggcc ctttgctatg gtgtcctttc aattgctctc

1021 atccctgagt tcagagctcc taagagagtt gtgaagaaac tcatgggtct tgggaagaga

1081 aaccagggag atcctttgat gatcattcct gcagcagctc agagggttcc cctactgtca

1141 tcccccagcc gcttcatccc tgaaaactgt ggccagtttg ttatttataa ccacctaaaa

1201 ttagttctaa tagaactcat ttttaactag aagtaatgca attcctctgg gaatggtgta

1261 ttgtttgtct gcctttgtag cagcatctaa ttttgaataa atggatctta ttcg

(2) INFORMATION FOR SEQ ID NO: 68: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 7207 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 68: cagtcaggag agagggcagt gagggtccat gctagctggg tcttgagcct cttctggggt

61 tcagtctctg atctacagca gtgtgtccac acctaaaaca tcagctcaga gaggcagttg

121 cttctgctgt tggaaacgga catcccaaaa aaaaacaaaa aacagaaatc aaaagggaag

181 gagaaagtga aagggatgga ggcagcttgt ccccttccct gtgcttgctg ctggtagaaa

241 actcagcctg gaactgaccg gagcagcagt tcttgagtca attccattcc aacttctaga

301 agattctttt cccgtcgaag agtgtcagga ggagaggcca gacccccttg atcctgatct

361 gccagccact gcatcagata agacgagata accccgagtt cctgttctac cagccctggt

421 gtggtaaccc tctccaatgg ggcaggcttg gaaccctgtg ccaacgaaga tcctcccccg

481 tactgatgca ggaaggacag cccgggagtg taccctctac atgggtctac ttttatttaa

541 gcaaacattc cctggtcaac aggacgtgta gcattgcccc cccccttggg tcacacagaa

601 aacaggtacc aggaggacaa gtagttgctt gcccagggta cagaatgaaa ggcaataggg

661 gactctaggc gaatgttctt cccacccaaa ctgaggtagt aggagaagtc cctactgaag

721 ggaaggtcca gacataatca aaggactacc agagatctcc caggtatctg tagaagtact

781 aacatctcca tccttcaaca gctacaggtt acacgtctcc aaggctggga cattgtaaaa

841 cagggccatg gtaaggtcta cccgacagca cagagcaagc ctcccagaag tctgagttcc

901 ttctcctaac ttctcatgct gggatctgag cttcttcgtg aaacacgggg cagaggaggc

961 accagaactc tcctctgacc aactgcccca cagcacacat atcctcaaag gatagtcttg 1021 aatacgtgat ggaagaatta aagagagtga ggtctgaaga aaatcagccc tctcggggtt 1081 tcctttgggt aactgagtgc taaggtgact tccgagtcag caagaaatat cggacgttca 1141 acccaggttg agtggaggaa acaattattt ctcaatccta atatgttctg gaatagccca 1201 tttatccacg tcattatgac ctgggagtgc gtgaatggaa tccacagatg agggcctctg 1261 tacatagaac agctgtctgc ctcaggaaat acaactttta gtattgagaa gctaaaaaga 1321 aaaaaaaatt aaaagagagg tagcccatac taaaaatagc tgtaatgcag aagttcattc 1381 cgaccagttc tttagcgctt acaatgcaaa aaaaagggaa aggaaaaaaa aaaagaaaga 1441 aattaaactc aaaaattgca tggtttagaa gagggaggag gagcctgaat aacaaaaacc 1501 tttgccagga aggccccact gagccttcag tataaaaggg ggaccaagaa caggaggtct 1561 acatttagag acttgctctt gcactaccaa agccacaagg cagccttgca gaaaagagag 1621 ctccatcatg cctggctcag cactgctatg ctgcctgctc ttactgactg gcatgaggat 1681 cagcaggggc cagtacagcc gggaagacaa taactgcacc cacttcccag tcggccagag 1741 ccacatgctc ctagagctgc ggactgcctt cagccaggtg aagactttct ttgtaagtat 1801 gagctcgcct agcctttctt cctgccatca cctgaaatat gcattctgat ggaactgcaa 1861 aaatagctct ccttctcctc ctccttctcc tccttctctt tctcctcctc tgctttctcc 1921 tccttctctt cctcctcctt ctcttcttcc tcctctccct cttcctcctc cagctcttac 1981 ctcatgctgc tcctccccta tttccagcac ctattaccct taaacttaaa tctagagagt 2041 cctagggaaa gccatgagtt aaactaaacc caggcacatc cgaaaagcta actaggaggt 2101 gaatgcattg tctctcccat gctcaagaac tttctgttaa gtttccaata aggctccatg 2161 ttttgctggc taggacaaaa gtctgtggtc tctgcgtagt ctctagatct gggggacaga 2221 ggtttggggg tttgaagcag caccagcata gagagcttgc attacaaaag tattcccctt 2281 tcagagctcc tggaactggt atggaggtcc aaagaaggca gagagctatg caaaacaggc 2341 tttctataag ggactccaga aaggaagggt tgacacaggt gctcttgaaa cctgatctga 2401 ctcatctgaa agaagaccgg gcctgggtct aacttctccc agtcagttaa attcagtcag 2461 aagtttttaa aaacaactgg atcccaagag gaaggacttt gatttaactc cgggctctag 2521 cactgtcaaa tcctgttctt aaaactctcc tttccacagt tgccagggca tttgaattga 2581 ttacaaattc aaaactctac aaatggaaaa gtattcaaat gacatgcaca ttgggtattt 2641 tccccagtcc ttgcattcac gttctttatg ttcttccagc aaacaaagga ccagctggac 2701 aacatactgc taaccgactc cttaatgcag gactttaagg taagagtccg gtgggtgctg 2761 gggagcgacc aagcgattag ggacgggacg ggaggtgctg cttgtgacag cagagctggg 2821 tctgatgcct tgactttcaa aaagagaagt gagaagacct tgactcagca tatcgccagc 2881 agtcaagggt tgtgaagagc tcattctgtg gtaaagggag aaaatgtaac tagaaggggc 2941 ggggatgggg ggggggtccc taggaacagg acagtccatc aaggttagca gcaacagatc 3001 accattccag taagtcacac ccaacctctg atccctgcct ctagggttac ttgggttgcc 3061 aagccttatc ggaaatgatc cagttttacc tggtagaagt gatgccccag gcagagaagc 3121 atggcccaga aatcaaggag catttgaatt ccctgggtga gaagctgaag accctcagga 3181 tgcggctgag gcgctgtgtg agtagcagat gcgttcttcc ccacccccaa tccccttaga EPI-109 1235

3241 gccacccaac aaatactgtc tcctacagcc cagtcaggcc acatgcatcc agagacacac 3301 acagactaga caggagacta ggtaaatcta gagagacgcc tgtccggtgt cgggtctctt 3361 gctcatctgt ctctgagcga gtgtgggagt gactttgagg cactcacacg tgaagatttg 3421 cgcatagcct tcctgttatt tgtgagtcat tgtgggttat tagctactcc cctctctctc 3481 catgggaagg ctggggcttc agtcatggct ccctcacctc tgggctgcca gctgaggctc 3541 ccaagcacag gaaaacattc atctctttat ctcatctttt gggaagcaaa ttcagtggca 3601 cagagctggg ctgacaggac gctggtgttt cagaagggcc agaagactgc tatccctaag 3661 ccagtatcta tgaataatac agtcggggca tctatgtctc tgaagcgatg ccttggctgc 3721 tcttgttttt cttacttctc tcactgatac tgggacatca gctggagtct acttgtgcaa 3781 cggttctggc ctgacgattt ggccccagta gctgagactt tcgctcctct ctcagacacc 3841 tagaaatagt tcatggtggt tgagattgga gatagacaag aagagacact aaaaacagaa 3901 caggtgcctt ggagctctga gagacaaaac ccgagacctg agttcacacc cacacttagc 3961 aagccatctt agtgattgca aagacataca ttgcatcttt ctaggctgtc ctctgctgtc 4021 cccctcagtc cctaccgaaa tagataagga ccaatcacgg ctcagttctc cctgggagct 4081 aagaagtggg cattgaagat gagcaagggt gtctccttcc tcacacaaca agatagtttc 4141 ccccaagtac catggatgca gaattcaagc aagaattacc aatgctctct tttttcttct 4201 tcagcatcga tttctcccct gtgaaaataa gagcaaggca gtggagcagg tgaagagtga 4261 ttttaataag gtaagtggca aagggggcga gtgtaacaag acctctgtct actcaccaaa 4321 gcgcagaagg agggcgggag ctattctgca cctggagtgt gggaacccag caaatggtgt 4381 gacctcctct gccagttaga aagccaccac ctcagttaca tttgttttct gcaaagcgtc 4441 tctggcagtt tctaaatgac tgctccactt ttgcaggctt ttggcttaga ctgaccagac 4501 agcctatgag cacagggcac taggtgttga ggagagtgac ataggaaaca gaaagtacag 4561 aaagtacctt gttgggaaac aggctgaacc cacaagtaca gaaagcagac atgaattaat 4621 ttactcaggt acatcattgg ggctcagcct ggatgcccct cccccaaatc agaacgagca 4681 gaaagcagaa ttcttacttg tcccggggca ctttccacct ggcaaacaaa atgaggtttc 4741 acacttccaa ctgcctgtga acctattcaa ccctagttcc cagaagccat gtggcctaca 4801 tcatcatctt tgtgggctag gcagagacac ctggcagggc tctaacatta gtgggcatga 4861 attccatgac agcaggtcag agctgcaggg tgaggactgc ctacacactc aaaacataaa 4921 aaaaaaaaaa aaaaaacacc aaccatttcc ctgctatctc tatcactgcc ctgcttacaa 4981 actgctccct ctggcatctt tgcataacat tctgcataag cattatatga gcactggcct 5041 cttaaaaaaa attagttgaa aaggtgccac cctgaagaca gtgctttggg gactgaatgc 5101 ttcccttgct gactcctggc agtgcttaaa gctgggagaa ggttggtccc accacatcct 5161 gactactaca gtatagttgt ctctcttctt tcatttccct gtccccattt ctttattgta 5221 cataaagtaa ctggtgtatg tgcacacaca tagtgctctc tctttctttt ccttttttaa 5281 actaaatggc cgatgttctg ttctggttgg catcagatgg agatggtctg ggggaaagta 5341 ctgggtttgt gaaaataccc ccttctccat tagtggcatg ctctttcagc tcttatcttt 5401 atattccagt aagttatttt gctctcattg ttttaacaaa agaacccaac aacaccaaat 5461 ctttgcatac cttgttcgat tggagaattt taatgttttt catttatcat tgtaaaaccg 5521 aggacaattt tataactttt ttgtacgtgg ctgttacatg tagggcaatc tgtctttaag 5581 tagggataaa ttactcttga ataaaatgat cctagatagt tttcccttca agtcaagcgt 5641 cttgttgttt aaataaactt cttgtttaaa atgaaaaaaa aaaaaacaaa caaacaaaaa 5701 aaagctggga gaaggtatag gagaaacagg ggaaggcacg gccccttccc aaagcagacg 5761 gacaaatctt tgggtccttc agctcccaac acaagaaagc agagatcttt ctatgctcag 5821 catccttccc agggcaggga gcccctcagc ccaccaatgg gtactaacca gatgcttctc 5881 tccccacaca gctccaagac caaggtgtct acaaggccat gaatgaattt gacatcttca 5941 tcaactgcat agaagcatac atgatgatca aaatgaaaag ctaaaacacc tgcagtgtgt 6001 attgagtctg ctggactcca ggacctagac agagctctct aaatctgatc cagggatctt 6061 agctaacgga aacaactcct tggaaaacct cgtttgtacc tctctccgaa atatttatta 6121 cctctgatac ctcagttccc attctattta ttcactgagc ttctctgtga actatttaga 6181 aagaagccca atattataat tttacagtat ttattatttt taacctgtgt ttaagctgtt 6241 tccattgggg acactttata gtatttaaag ggagattata ttatatgatg ggaggggttc 6301 ttccttggga agcaattgaa gcttctattc taaggctggc cacacttgag agctgcaggg 6361 ccctttgcta tggtgtcctt tcaattgctc tcatccctga gttcagagct cctaagagag 6421 ttgtgaagaa actcatgggt cttgggaaga gaaaccaggg agatcctttg atgatcattc 6481 ctgcagcagc tcagagggtt cccctactgt catcccccag ccgcttcatc cctgaaaact 6541 gtggccagtt tgttatttat aaccacctaa aattagttct aatagaactc atttttaact 6601 agaagtaatg caattcctct gggaatggtg tattgtttgt ctgcctttgt agcagactct 6661 aattttgaat aaatggatct tattcgaatt acagtgtggt gtctattgag ttctgtctga 6721 tttaaaagaa aaatccctta aaattccaga gggcagaagc agtgaatctt agactccaca 6781 aaaagaatgc cagcaacctc tccaggaagg ggttgagctc ggatcagatc agaggaaagt 6841 cttgcctggc tttcaaagca tcagcataaa ctactgatat cttcaagctc agtcctttaa 6901 aatgtgtcct gaaaccttaa aaggcattct accttccaaa gctagggaag gtgattctaa 6961 gtaaccatcg gaaggaagtg ggaagcatca aagctgaaac tctgagacga aatgttgggg 7021 ttaaaaatgg aagctagggg caggagggtg gggagatggc tcagcagtta gagtgtgtgc 7081 cggcaccagt gagacaggag ttcatatcct tggaatccaa ccaacacaca accaacacta 7141 ggcaagagat gcctaatgtg tcagtggttg cttcaagctc cagaggtcct ggggtgaact 7201 tagatcc

INFORMATION FOR SEQ ID NO: 69: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15530 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 69: EPI-109 1236 gatccccaga gactttc :ag atatctgaag aagtcctc at gtcactgccc cggtccttcc 61 ccaggtagag caacactcct cgtcgcaacc caactggctc cccttacctt ctacacacac

121 acacacacac acacacacac acacacacac acacacaaat ccaagacaac actactaagg 181 cttctttggg agggggaagt agggataggt aagaggaaag taagggacct cctatccagc 241 ctccatggaa tcctgacttc ttttccttgt tatttcaact tcttccaccc catcttttaa 301 actttagact ccagccacag aagcttacaa ctaaaagaaa ctctaaggcc aatttaatcc 361 aaggtttcat tctatgtgct ggagatggtg tacagtaggg tgaggaaacc aaattctcag 421 ttggcactgg tgtacccttg tacaggtgat gtaacatctc tgtgcctcag tttgctcact 481 ataaaataga gacggtaggg gtcatggtga gcactacctg actagcatat aagaagcttt 541 cagcaagtgc agactactct tacccacttc ccccaagcac agttggggtg ggggacagct 601 gaagaggtgg aaacatgtgc ctgagaatcc taatgaaatc ggggtaaagg agcctggaac 661 acatcctgtg accccgcctg tcctgtagga agccagtctc tggaaagtaa aatggaaggg 721 ctgcttggga actttgagga tatttagccc accccctcat ttttacttgg ggaaactaag 781 gcccagagac ctaaggtgac tgcctaagtt agcaaggaga agtcttgggt attcatccca 841 ggttgggggg acccaattat ttctcaatcc cattgtattc tggaatgggc aatttgtcca 901 cgtcactgtg acctaggaac acgcgaatga gaacccacag ctgagggcct ctgcgcacag 961 aacagctgtt ctccccagga aatcaacttt ttttaattga gaagctaaaa aattattcta 1021 agagaggtag cccatcctaa aaatagctgt aatgcagaag ttcatgttca accaatcatt 1081 tttgcttacg atgcaaaaat tgaaaactaa gtttattaga gaggttagag aaggaggagc 1141 tctaagcaga aaaaatcctg tgccgggaaa ccttgattgt ggctttttaa tgaatgaaga 1201 ggcctccctg agcttacaat ataaaagggg gacagagagg tgaaggtcta cacatcaggg 1261 gcttgctctt gcaaaaccaa accacaagac agacttgcaa aagaaggcat gcacagctca 1321 gcactgc aaaccacaag acagacttgc aaaagaaggc atgcacagct cagcactgct ctgttgcctg

61 gtcctcctga ctggggtgag ggccagccca ggccagggca cccagtctga gaacagctgc

121 acccacttcc caggcaacct gcctaacatg cttcgagatc tccgagatgc cttcagcaga

181 gtgaagactt tctttcaaat gaaggatcag ctggacaact tgttgttaaa ggagtccttg 241 ctggaggact ttaagggtta cctgggttgc caagccttgt ctgagatgat ccagttttac 301 ctggaggagg tgatgcccca agctgagaac caagacccag acatcaaggc gcatgtgaac

361 tccctggggg agaacctgaa gaccctcagg ctgaggctac ggcgctgtca tcgatttctt 421 ccctgtgaaa acaagagcaa ggccgtggag caggtgaaga atgcctttaa taagctccaa 481 gagaaaggca tctacaaagc catgagtgag tttgacatct tcatcaacta catagaagcc

541 tacatgacaa tgaagatacg aaactgagac atcagggtgg cgactctata gactctagga

601 cataaattag aggtctccaa aatcggatct ggggctctgg gatagctgac ccagcccctt

661 gagaaacctt attgtacctc tcttatagaa tatttattac ctctgatacc tcaaccccca

721 tttctattta tttactgagc ttctctgtga acgatttaga aagaagccca atattataat

781 ttttttcaat atttattatt ttcacctgtt tttaagctgt ttccataggg tgacacacta

841 tggtatttga gtgttttaag ataaattata agttacataa gggaggaaaa aaaatgttct

901 ttggggagcc aacagaagct tccattccaa gcctgaccac gctttctagc tgttgagctg

961 ttttccctga cctccctcta atttatcttg tctctgggct tggggcttcc taactgctac

1021 aaatactctt aggaagagaa accagggagc ccctttgatg attaattcac cttccagtgt

1081 ctcggaggga ttcccctaac ctcattcccc aaccacttca ttcttgaaag ctgtggccag

1141 cttgttattt ataacaacct aaatttggtt ctaggccggg cgcggtggct cacgcctgta

1201 atcccagcac tttgggaggc tgaggcgggt ggatcacttg aggtcaggag ttcctaacca

1261 gcctggtcaa catggtgaaa ccccgtctct actaaaaata caaaaattag ccgggcatgg

1321 tggcgcgcac ctgtaatccc agctacttgg gaggctgagg caagagaatt gcttgaaccc

1381 aggagatgga agttgcagtg agctgatatc atgcccctgt actccagcct gggtgacaga

1441 gcaagactct gtctcaaaaa aataaaaata aaaataaatt tggttctaat agaactcagt

1501 tttaactaga atttattcaa ttcctctggg aatgttacat tgtttgtctg tcttcatagc

1561 agattttaat tttgaataaa taaatgtatc ttattcacat c agatcttgta aactgtagaa tgcaccctcc aaaatctatt tgcataagca cacacacaca

61 cacacacaca cacaccccag cagttcttgc ctgcccagat tcctctgcag ctaaagtgat

121 gaaacttact gggcggagct tcctaaaaag attattaggg tctcctgggt tggtgtgcct

181 ttaaaccttt ggactttacc acctcctatc tctcctatct ccttgcaaca aaggttagga

241 gaacaagaat gcagaaaaaa cgggtcctgg atgacatctg agtgcctgct ttgggcttct

301 tgatgagtga gacagaaaat aaaatacaac cccctctttt aaaagccatg cttactcagg

361 ttttccttca tttgcagcta aatacagaaa tgagagaata ttttggagca gggatggaag

421 aagagaggta ttccccttcc cacaaccttc tgatttccca gtacatcccc cactggaaaa

481 attcatttaa aatcagtata ataagcattg attagatgcc tactatgcat ctgggcttga

541 gggcaaactg gactcaggcc ttttggcctc aagaagctca cagtgtgaga gtggcatttg

601 tgtcctcttg aaattcacag gactaaattg tgcccaggct gacattctat ccatccatag

661 gtgcctgcct tctcacttcc ctctcttcat gggctcttgc cttgtaccaa aatccaaacc

721 caaatctcct cacatgtgag tgttggcatt catgtctcag acatgaccta tgggcttggg

781 acttttcccc gtggacccca gtgacttttc agatgaacag gtatcttcaa aaacttgaga

841 aataggagtc ctgtttgttg ttcttgttgc tttgtcaata taaggcacag ggtctttatt

901 caaatgttca tactatctct tgacagaaat actatgagac atattgatgg agaagccgtt

961 atctccatat gctaaatgag gacttgcacc agggaacttg cccatggttc tctccaacca

1021 cttaaattct gaaattttga atgagagtgg acagtaattt caaatcaatg gggaaagaat

1081 caaatcttca gcaaatggct tgagataatt agctacacat ttcagaacaa ataaagaagt

1141 cagatccggg ccgggcacag tggctcatgc ctgtaatctc agcactctgg gaggccaagg

1201 cgggcggatc ataaggtcag gagatcgaga ccatcctggt taacacagtg aacccctctc

1261 taataaaaat acaaaaaaaa ataaaaaaac ttagccgggc gtggtgccag gcgcctgtag

1321 tcccagctac tcgggacgct gaggcaggag aatggcttga actcgggagg cagagcttgc

1381 aggtgagctg agatcatgcc actgcactcc agcctgggca acagagcgag actctgtctc

1441 aaaaaaaaaa aagaagtcag atcctaacct caaccctatt taacagatta tagatgaaag EPI-109 1237

1501 aaaggtacaa atggctttta catacctccc ttctccctga cattttgtat gtgtgtgtgt 1561 gtgtatttac acacacatct catataagga aattgaaggg aggctgcctg catccctgag 1621 tcactctccc tctccttctg aatgcttacc tgtgcccaga ccacctcctt agcctcgcac 1681 cctccaggct tacagggcac tcttctatgc ccatcccaag tatagctgaa ccttccaagg 1741 gccagacttg gtgctaagta ccaagtacgc aaagattaat aaaacaatgt cctgtttcag 1801 ggagctcaaa gctgattcgg cagggcatgg tgtgtacatg aatgataacc acgtagggtt 1861 gcaggtttcc tagtgaggta agcacaaggc aagatgggaa acaaaggaag gaggggttca 1921 cagcctcacc cagagtccag aacccctggc ctgcctggtg cccatgctga gtccacttct 1981 ggaacaccca gctcagagag ggggttagac ctgcaggcta acacagacac agcccagaaa 2041 acccaggagc cgagggggaa ggagaaaggt gcaagaaggg gaaacccagg tcctggtccc

2101 cttctctctg cttcctggaa gcagaactca gacagaaccc ttaagccagt ctaagtctgg 2161 caggaccagt aagttctgag ttagctccat actagtttct agcaggctct ttctcacttc

2221 ctgattctta ggtttctaca ttgacactcc ctgaagagtt gggaagagac accacagtcc 2281 cctgaccctg atccataggt cacacagcag gcatccacag ggtgggcgtg ggccctctca 2341 tccctccctc ccactcactt cacgctggct gggccccaag gtgtttgcac cccttgcagt 2401 gagtgacctt ctctagtgca gcaagctcag aacctgctgc cactggagtt gtcccattgc 2461 tgatgcagaa aggtgaagaa ctagcagaac actggaaatg ccctccatct gggtccatgg 2521 ctacttaatg ctccctggca ggcaggagga caggtgctat tccctgttgg gacagatgaa 2581 aaacagacac agggaggatg agtgatttgc cctgactata gagtggcagg gccaaggcag 2641 agcccaggcc tcctgcacct aggtcagtgt tcctcccagt tacagtctaa actggaatgc 2701 aggcaaagcc cctgtggaag gggaaggtga aggctcaatc aaaggatccc cagagacttt 2761 ccagatatct gaagaagtcc tgatgtcact gccccggtcc ttccccaggt agagcaacac 2821 tcctcgccgc aacccaactg gctcccctta ccttctacac acacacacac acacacacac 2881 acacacacac acacacacaa atccaagaca acactactaa ggcttctttg ggaaggggaa 2941 gtagggatag gtaagaggaa agtaagggac ctcctatcca gcctccatgg aatcctgact 3001 tcttttcctt gttatttcaa cttcttccac cccatctttt aaactttaga ctccagccac 3061 agaagcttac aactaaaaga aactctaagg ccaatttaat ccaaggtttc attctatgtg 3121 ctggagatgg tgtacagtag ggtgaggaaa ccaaattctc agttggcact ggtgtaccct 3181 tgtacaggtg atgtaacatc tctgtgcctc agtttgctca ctataaaata gagacggtag 3241 gggtcatggt gagcactacc tgactagcat ataagaagct ttcagcaagt gcagactact 3301 cttacccact tcccccaagc acagttgggg tgggggacag ctgaagaggt ggaaacatgt 3361 gcctgagaat cctaatgaaa tcggggtaaa ggagcctgga acacatcctg tgaccccgcc 3421 tgtcctgtag gaagccagtc tctggaaagt aaaatggaag ggctgcttgg gaactttgag 3481 gatatttagc ccaccccctc atttttactt ggggaaacta aggcccagag acctaaggtg 3541 actgcctaag ttagcaagga gaagtcttgg gtattcatcc caggttgggg ggacccaatt 3601 atttctcaat cccattgtat tctggaatgg gcaatttgtc cacgtcactg tgacctagga 3661 acacgcgaat gagaacccac agctgagggc ctctgcgcac agaacagctg ttctccccag 3721 gaaatcaact ttttttaatt gagaagctaa aaaattattc taagagaggt agcccatcct 3781 aaaaatagct gtaatgcaga agttcatgtt caaccaatca tttttgctta cgatgcaaaa 3841 attgaaaact aagtttatta gagaggttag agaaggagga gctctaagga gaaaaaatcc 3901 tgtgccggga aaccttgatt gtggcttttt aatgaatgaa gaggcctccc tgagcttaca 3961 atataaaagg gggacagaga ggtgaaggtc tacacatcag gggcttgctc ttgcaaaacc 4021 aaaccacaag acagacttgc aaaagaaggc atgcacagct cagcactgct ctgttgcctg 4081 gtcctcctga ctggggtgag ggccagccca ggccagggca cccagtctga gaacagctgc 4141 acccacttcc caggcaacct gcctaacatg cttcgagatc t

1 gggggggggg atttagagac ttgctcttgc actaccaaag ccacaaagca gccttgcaga

61 aaagagagct ccatcatgcc tggctcagca ctgctatgct gcctgctctt actgactggc

121 atgaggatca gcaggggcca gtacagccgg gaagacaata actgcaccca cttcccagtc

181 ggccagagcc acatgctcct agagctgcgg actgccttca gccaggtgaa gactttcttt

241 caaacaaagg accagctgga caacatactg ctaaccgact ccttaatgca ggactttaag

301 ggttacttgg gttgccaagc cttatcggaa atgatccagt tttacctggt agaagtgatg

361 ccccaggcag agaagcatgg cccagaaatc aaggagcatt tgaattccct gggtgagaag

421 ctgaagaccc tcaggatgcg gctgaggcgc tgtcatcgat ttctcccctg tgaaaataag

481 agcaaggcag tggagcaggt gaagagtgat tttaataagc tccaagacca aggtgtctac

541 aaggccatga atgaatttga catcttcatc aactgcatag aagcatacat gatgatcaaa

601 atgaaaagct aaaacacctg cagtgtgtat tgagtctgct ggactccagg acctagacag

661 agctctctaa atctgatcca gggatcttag ctaacggaaa caactccttg gaaaacctcg

721 tttgtacctc tctccgaaat atttattacc tctgatacct cagttcccat tctatttatt

781 cactgagctt ctctgtgaac tatttagaaa gaagcccaat attataattt tacagtattt

841 attattttta acctgtgttt aagctgtttc cattggggac actttatagt atttaaaggg

901 agattatatt atatgatggg aggggttctt ccttgggaag caattgaagc ttctattcta

961 aggctggcca cacttgagag ctgcagggcc ctttgctatg gtgtcctttc aattgctctc

1021 atccctgagt tcagagctcc taagagagtt gtgaagaaac tcatgggtct tgggaagaga

1081 aaccagggag atcctttgat gatcattcct gcagcagctc agagggttcc cctactgtca

1141 tcccccagcc gcttcatccc tgaaaactgt ggccagtttg ttatttataa ccacctaaaa

1201 ttagttctaa tagaactcat ttttaactag aagtaatgca attcctctgg gaatggtgta

1261 ttgtttgtct gcctttgtag cagcatctaa ttttgaataa atggatctta ttcg cagtcaggag agagggcagt gagggtccat gctagctggg tcttgagcct cttctggggt

61 tcagtctctg atctacagca gtgtgtccac acctaaaaca tcagctcaga gaggcagttg 121 cttctgctgt tggaaacgga catcccaaaa aaaaacaaaa aacagaaatc aaaagggaag 181 gagaaagtga aagggatgga ggcagcttgt ccccttccct gtgcttgctg ctggtagaaa 241 actcagcctg gaactgaccg gagcagcagt tcttgagtca attccattcc aacttctaga 301 agattctttt cccgtcgaag agtgtcagga ggagaggcca gacccccttg atcctgatct 361 gccagccact gcatcagata agacgagata accccgagtt cctgttctac cagccctggt 421 gtggtaaccc tctccaatgg ggcaggcttg gaaccctgtg ccaacgaaga tcctcccccg EPI-109 1238

481 tactgatgca ggaaggacag cccgggagtg taccctctac atgggtctac ttttatttaa 541 gcaaacattc cctggtcaac aggacgtgta gcattgcccc cccccttggg tcacacagaa 601 aacaggtacc aggaggacaa gtagttgctt gcccagggta cagaatgaaa ggcaataggg 661 gactctaggc gaatgttctt cccacccaaa ctgaggtagt aggagaagtc cctactgaag 721 ggaaggtcca gacataatca aaggactacc agagatctcc caggtatctg tagaagtact 781 aacatctcca tccttcaaca gctacaggtt acacgtctcc aaggctggga cattgtaaaa 841 cagggccatg gtaaggtcta cccgacagca cagagcaagc ctcccagaag tctgagttcc 901 ttctcctaac ttctcatgct gggatctgag cttcttcgtg aaacacgggg cagaggaggc 961 accagaactc tcctctgacc aactgcccca cagcacacat atcctcaaag gatagtcttg 1021 aatacgtgat ggaagaatta aagagagtga ggtctgaaga aaatcagccc tctcggggtt 1081 tcctttgggt aactgagtgc taaggtgact tccgagtcag caagaaatat cggacgttca 1141 acccaggttg agtggaggaa acaattattt ctcaatccta atatgttctg gaatagccca 1201 tttatccacg tcattatgac ctgggagtgc gtgaatggaa tccacagatg agggcctctg 1261 tacatagaac agctgtctgc ctcaggaaat acaactttta gtattgagaa gctaaaaaga 1321 aaaaaaaatt aaaagagagg tagcccatac taaaaatagc tgtaatgcag aagttcattc 1381 cgaccagttc tttagcgctt acaatgcaaa aaaaagggaa aggaaaaaaa aaaagaaaga 1441 aattaaactc aaaaattgca tggtttagaa gagggaggag gagcctgaat aacaaaaacc 1501 tttgccagga aggccccact gagccttcag tataaaaggg ggaccaagaa caggaggtct 1561 acatttagag acttgctctt gcactaccaa agccacaagg cagccttgca gaaaagagag 1621 ctccatcatg cctggctcag cactgctatg ctgcctgctc ttactgactg gcatgaggat 1681 cagcaggggc cagtacagcc gggaagacaa taactgcacc cacttcccag tcggccagag 1741 ccacatgctc ctagagctgc ggactgcctt cagccaggtg aagactttct ttgtaagtat 1801 gagctcgcct agcctttctt cctgccatca cctgaaatat gcattctgat ggaactgcaa 1861 aaatagctct ccttctcctc ctccttctcc tccttctctt tctcctcctc tgctttctcc 1921 tccttctctt cctcctcctt ctcttcttcc tcctctccct cttcctcctc cagctcttac 1981 ctcatgctgc tcctccccta tttccagcac ctattaccct taaacttaaa tctagagagt 2041 cctagggaaa gccatgagtt aaactaaacc caggcacatc cgaaaagcta actaggaggt 2101 gaatgcattg tctctcccat gctcaagaac tttctgttaa gtttccaata aggctccatg 2161 ttttgctggc taggacaaaa gtctgtggtc tctgcgtagt ctctagatct gggggacaga 2221 ggtttggggg tttgaagcag caccagcata gagagcttgc attacaaaag tattcccctt 2281 tcagagctcc tggaactggt atggaggtcc aaagaaggca gagagctatg caaaacaggc 2341 tttctataag ggactccaga aaggaagggt tgacacaggt gctcttgaaa cctgatctga 2401 ctcatctgaa agaagaccgg gcctgggtct aacttctccc agtcagttaa attcagtcag 2461 aagtttttaa aaacaactgg atcccaagag gaaggacttt gatttaactc cgggctctag 2521 cactgtcaaa tcctgttctt aaaactctcc tttccacagt tgccagggca tttgaattga 2581 ttacaaattc aaaactctac aaatggaaaa gtattcaaat gacatgcaca ttgggtattt 2641 tccccagtcc ttgcattcac gttctttatg ttcttccagc aaacaaagga ccagctggac 2701 aacatactgc taaccgactc cttaatgcag gactttaagg taagagtccg gtgggtgctg 2761 gggagcgacc aagcgattag ggacgggacg ggaggtgctg cttgtgacag cagagctggg 2821 tctgatgcct tgactttcaa aaagagaagt gagaagacct tgactcagca tatcgccagc 2881 agtcaagggt tgtgaagagc tcattctgtg gtaaagggag aaaatgtaac tagaaggggc 2941 ggggatgggg ggggggtccc taggaacagg acagtccatc aaggttagca gcaacagatc 3001 accattccag taagtcacac ccaacctctg atccctgcct ctagggttac ttgggttgcc 3061 aagccttatc ggaaatgatc cagttttacc tggtagaagt gatgccccag gcagagaagc 3121 atggcccaga aatcaaggag catttgaatt ccctgggtga gaagctgaag accctcagga 3181 tgcggctgag gcgctgtgtg agtagcagat gcgttcttcc ccacccccaa tccccttaga 3241 gccacccaac aaatactgtc tcctacagcc cagtcaggcc acatgcatcc agagacacac 3301 acagactaga caggagacta ggtaaatcta gagagacgcc tgtccggtgt cgggtctctt 3361 gctcatctgt ctctgagcga gtgtgggagt gactttgagg cactcacacg tgaagatttg 3421 cgcatagcct tcctgttatt tgtgagtcat tgtgggttat tagctactcc cctctctctc 3481 catgggaagg ctggggcttc agtcatggct ccctcacctc tgggctgcca gctgaggctc 3541 ccaagcacag gaaaacattc atctctttat ctcatctttt gggaagcaaa ttcagtggca 3601 cagagctggg ctgacaggac gctggtgttt cagaagggcc agaagactgc tatccctaag 3661 ccagtatcta tgaataatac agtcggggca tctatgtctc tgaagcgatg ccttggctgc 3721 tcttgttttt cttacttctc tcactgatac tgggacatca gctggagtct acttgtgcaa 3781 cggttctggc ctgacgattt ggccccagta gctgagactt tcgctcctct ctcagacacc 3841 tagaaatagt tcatggtggt tgagattgga gatagacaag aagagacact aaaaacagaa 3901 caggtgcctt ggagctctga gagacaaaac ccgagacctg agttcacacc cacacttagc 3961 aagccatctt agtgattgca aagacataca ttgcatcttt ctaggctgtc ctctgctgtc 4021 cccctcagtc cctaccgaaa tagataagga ccaatcacgg ctcagttctc cctgggagct 4081 aagaagtggg cattgaagat gagcaagggt gtctccttcc tcacacaaca agatagtttc 4141 ccccaagtac catggatgca gaattcaagc aagaattacc aatgctctct tttttcttct 4201 tcagcatcga tttctcccct gtgaaaataa gagcaaggca gtggagcagg tgaagagtga 4261 ttttaataag gtaagtggca aagggggcga gtgtaacaag acctctgtct actcaccaaa 4321 gcgcagaagg agggcgggag ctattctgca cctggagtgt gggaacccag caaatggtgt 4381 gacctcctct gccagttaga aagccaccac ctcagttaca tttgttttct gcaaagcgtc 4441 tctggcagtt tctaaatgac tgctccactt ttgcaggctt ttggcttaga ctgaccagac 4501 agcctatgag cacagggcac taggtgttga ggagagtgac ataggaaaca gaaagtacag 4561 aaagtacctt gttgggaaac aggctgaacc cacaagtaca gaaagcagac atgaattaat 4621 ttactcaggt acatcattgg ggctcagcct ggatgcccct cccccaaatc agaacgagca 4681 gaaagcagaa ttcttacttg tcccggggca ctttccacct ggcaaacaaa atgaggtttc 4741 acacttccaa ctgcctgtga acctattcaa ccctagttcc cagaagccat gtggcctaca 4801 tcatcatctt tgtgggctag gcagagacac ctggcagggc tctaacatta gtgggcatga 4861 attccatgac agcaggtcag agctgcaggg tgaggactgc ctacacactc aaaacataaa 4921 aaaaaaaaaa aaaaaacacc aaccatttcc ctgctatctc tatcactgcc ctgcttacaa EPI-109 1239

4981 actgctccct ctggcatctt tgcataacat tctgcataag cattatatga gcactggcct

5041 cttaaaaaaa attagttgaa aaggtgccac cctgaagaca gtgctttggg gactgaatgc

5101 ttcccttgct gactcctggc agtgcttaaa gctgggagaa ggttggtccc accacatcct

5161 gactactaca gtatagttgt ctctcttctt tcatttccct gtccccattt ctttattgta

5221 cataaagtaa ctggtgtatg tgcacacaca tagtgctctc tctttctttt ccttttttaa

5281 actaaatggc cgatgttctg ttctggttgg catcagatgg agatggtctg ggggaaagta

5341 ctgggtttgt gaaaataccc ccttctccat tagtggcatg ctctttcagc tcttatcttt

5401 atattccagt aagttatttt gctctcattg ttttaacaaa agaacccaac aacaccaaat

5461 ctttgcatac cttgttcgat tggagaattt taatgttttt catttatcat tgtaaaaccg

5521 aggacaattt tataactttt ttgtacgtgg ctgttacatg tagggcaatc tgtctttaag

5581 tagggataaa ttactcttga ataaaatgat cctagatagt tttcccttca agtcaagcgt

5641 cttgttgttt aaataaactt cttgtttaaa atgaaaaaaa aaaaaacaaa caaacaaaaa

5701 aaagctggga gaaggtatag gagaaacagg ggaaggcacg gccccttccc aaagcagacg

5761 gacaaatctt tgggtccttc agctcccaac acaagaaagc agagatcttt ctatgctcag

5821 catccttccc agggcaggga gcccctcagc ccaccaatgg gtactaacca gatgcttctc

5881 tccccacaca gctccaagac caaggtgtct acaaggccat gaatgaattt gacatcttca

5941 tcaactgcat agaagcatac atgatgatca aaatgaaaag ctaaaacacc tgcagtgtgt

6001 attgagtctg ctggactcca ggacctagac agagctctct aaatctgatc cagggatctt

6061 agctaacgga aacaactcct tggaaaacct cgtttgtacc tctctccgaa atatttatta

6121 cctctgatac ctcagttccc attctattta ttcactgagc ttctctgtga actatttaga

6181 aagaagccca atattataat tttacagtat ttattatttt taacctgtgt ttaagctgtt

6241 tccattgggg acactttata gtatttaaag ggagattata ttatatgatg ggaggggttc

6301 ttccttggga agcaattgaa gcttctattc taaggctggc cacacttgag agctgcaggg

6361 ccctttgcta tggtgtcctt tcaattgctc tcatccctga gttcagagct cctaagagag

6421 ttgtgaagaa actcatgggt cttgggaaga gaaaccaggg agatcctttg atgatcattc

6481 ctgcagcagc tcagagggtt cccctactgt catcccccag ccgcttcatc cctgaaaact

6541 gtggccagtt tgttatttat aaccacctaa aattagttct aatagaactc atttttaact

6601 agaagtaatg caattcctct gggaatggtg tattgtttgt ctgcctttgt agcagactct

6661 aattttgaat aaatggatct tattcgaatt acagtgtggt gtctattgag ttctgtctga

6721 tttaaaagaa aaatccctta aaattccaga gggcagaagc agtgaatctt agactccaca

6781 aaaagaatgc cagcaacctc tccaggaagg ggttgagctc ggatcagatc agaggaaagt

6841 cttgcctggc tttcaaagca tcagcataaa ctactgatat cttcaagctc agtcctttaa

6901 aatgtgtcct gaaaccttaa aaggcattct accttccaaa gctagggaag gtgattctaa

6961 gtaaccatcg gaaggaagtg ggaagcatca aagctgaaac tctgagacga aatgttgggg

7021 ttaaaaatgg aagctagggg caggagggtg gggagatggc tcagcagtta gagtgtgtgc

7081 cggcaccagt gagacaggag ttcatatcct tggaatccaa ccaacacaca accaacacta

7141 ggcaagagat gcctaatgtg tcagtggttg cttcaagctc cagaggtcct ggggtgaact

7201 tagatcc

(2) INFORMATION FOR SEQ ID NO:70: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3632 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 70 : 1 aaagagctgg aggcgcgcag gccggctccg ctccggcccc ggacgatgcg gcgcgcccag

61 gatgctgccg tgcctcgtag tgctgctggc ggcgctcctc agcctccgtc ttggctcaga

121 cgctcatggg acagagctgc ccagccctcc gtctgtgtgg tttgaagcag aatttttcca

181 ccacatcctc cactggacac ccatcccaaa tcagtctgaa agtacctgct atgaagtggc

241 gctcctgagg tatggaatag agtcctggaa ctccatctcc aactgtagcc agaccctgtc

301 ctatgacctt accgcagtga ccttggacct gtaccacagc aatggctacc gggccagagt

361 gcgggctgtg gacggcagcc ggcactccaa ctggaccgtc accaacaccc gcttctctgt

421 ggatgaagtg actctgacag ttggcagtgt gaacctagag atccacaatg gcttcatcct

481 cgggaagatt cagctaccca ggcccaagat ggcccccgcg aatgacacat atgaaagcat

541 cttcagtcac ttccgagagt atgagattgc cattcgcaag gtgccgggaa acttcacgtt

601 cacacacaag aaagtaaaac atgaaaactt cagcctccta acctctggag aagtgggaga

661 gttctgtgtc caggtgaaac catctgtcgc ttcccgaagt aacaagggga tgtggtctaa

721 agaggagtgc atctccctca ccaggcagta tttcaccgtg accaacgtca tcatcttctt

781 tgcctttgtc ctgctgctct ccggagccct cgcctactgc ctggccctcc agctgtatgt

841 gcggcgccga aagaagctac ccagtgtcct gctcttcaag aagcccagcc ccttcatctt

901 catcagccag cgtccctccc cagagaccca agacaccatc cacccgcttg atgaggaggc

961 ctttttgaag gtgtccccag agctgaagaa cttggacctg cacggcagca cagacagtgg

1021 ctttggcagc accaagccat ccctgcagac tgaagagccc cagttcctcc tccctgaccc

1081 tcacccccag gctgacagaa cgctgggaaa cggggagccc cctgtgctgg gggacagctg

1141 cagtagtggc agcagcaata gcacagacag cgggatctgc ctgcaggagc ccagcctgag

1201 ccccagcaca gggcccacct gggagcaaca ggtggggagc aacagcaggg gccaggatga

1261 cagtggcatt gacttagttc aaaactctga gggccgggct ggggacacac agggtggctc

1321 ggccttgggc caccacagtc ccccggagcc tgaggtgcct ggggaagaag acccagctgc

1381 tgtggcattc cagggttacc tgaggcagac cagatgtgct gaagagaagg caaccaagac

1441 aggctgcctg gaggaagaat cgcccttgac agatggcctt ggccccaaat tcgggagatg

1501 cctggttgat gaggcaggct tgcatccacc agccctggcc aagggctatt tgaaacagga

1561 tcctctagaa atgactctgg cttcctcagg ggccccaacg ggacagtgga accagcccac

1621 tgaggaatgg tcactcctgg ccttgagcag ctgcagtgac ctgggaatat ctgactggag

1681 ctttgcccat gaccttgccc ctctaggctg tgtggcagcc ccaggtggtc tcctgggcag EPI-109 1240

1741 ctttaactca gacctggtca ccctgcccct catctctagc ctgcagtcaa gtgagtgact

1801 cgggctgaga ggctgctttt gattttagcc atgcctgctc ctctgcctgg accaggagga

1861 gggccctggg gcagaagtta ggcacgaggc agtctgggca cttttctgca agtccactgg

1921 ggctggccca gccaggctgc agggctggtc agggtgtctg gggcaggagg aggccaactc

1981 actgaactag tgcagggtat gtgggtggca ctgacctgtt ctgttgactg gggccctgca

2041 gactctggca gagctgagaa gggcagggac cttctccctc ctaggaactc tttcctgtat

2101 cataaaggat tatttgctca ggggaaccat ggggctttct ggagttgtgg tgaggccacc

2161 aggctgaagt cagctcagac ccagacctcc ctgcttaggc cactcgagca tcagagcttc

2221 cagcaggagg aagggctgta ggaatggaag cttcagggcc ttgctgctgg ggtcattttt

2281 ^aggggaaaaa ggaggatatg atggtcacat ggggaacctc ccctcatcgg gcctctgggg

2341 caggaagctt gtcactggaa gatcttaagg tatatatttt ctggacactc aaacacatca

2401 taatggattc actgagggga gacaaaggga gccgagaccc tggatggggc ttccagctca

2461 gaacccatcc ctctggtggg tacctctggc acccatctgc aaatatctcc ctctctccaa

2521 caaatggagt agcatccccc tggggcactt gctgaggcca agccactcac atcctcactt

2581 tgctgcccca ccatcttgct gacaacttcc agagaagcca tggttttttg tattggtcat

2641 aactcagccc tttgggcggc ctctgggctt gggcaccagc tcatgccagc cccagagggt

2701 cagggttgga ggcctgtgct tgtgtttgct gctaatgtcc agctacagac ccagaggata

2761 agccactggg cactgggctg gggtccctgc cttgttggtg ttcagctgtg tgattttgga

2821 ctagccactt gtcagagggc ctcaatctcc catctgtgaa ataaggactc cacctttagg

2881 ggaccctcca tgtttgctgg gtattagcca agctggtcct gggagaatgc agatactgtc

2941 cgtggactac caagctggct tgtttcttat gccagaggct aacagatcca atgggagtcc

3001 atggtgtcat gccaagacag tatcagacac agccccagaa gggggcatta tgggccctgc

3061 ctccccatag gccatttgga ctctgccttc aaacaaaggc agttcagtcc acaggcatgg

3121 aagctgtgag gggacaggcc tgtgcgtgcc atccagagtc atctcagccc tgcctttctc

3181 tggagcattc tgaaaacaga tattctggcc cagggaatcc agccatgacc cccacccctc

3241 tgccaaagta ctcttaggtg ccagtctggt aactgaactc cctctggagg caggcttgag

3301 ggaggattcc tcagggttcc cttgaaagct ttatttattt attttgttca tttatttatt

3361 ggagaggcag cattgcacag tgaaagaatt ctggatatct caggagcccc gaaattctag

3421 ctctgacttt gctgtttcca gtggtatgac cttggagaag tcacttatcc tcttggagcc

3481 tcagtttcct catctgcaga ataatgactg acttgtctaa ttcataggga tgtgaggttc

3541 tgctgaggaa atgggtatga atgtgccttg aacacaaagc tctgtcaata agtgatacat

3601 gttttttatt ccaataaatt gtcaagacca ca

(2) INFORMATION FOR SEQ ID NO: 71: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1696 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 71:

1 gctgtagctg gtgagaggaa gtcctagagg ctatggacac tctgctgctg ggatcaccga

61 gatgagcagc agctgctcag ggctgagcag ggtcctggtg gccgtggcta cagccctggt 121 gtctgcctcc tccccctgcc cccaggcctg gggcccccca ggggtccagt atgggcagcc 181 agggaggtcc gtgaagctgt gttgtcctgg agtgactgcc ggggacccag tgtcctggtt 241 tcgggatggg gagccaaagc tgctccaggg acctgactct gggctagggc atgaactggt 301 cctggcccag gcagacagca ctgatgaggg cacctacatc tgccagaccc tggatggtgc 361 acttgggggc acagtgaccc tgcagctggg ctaccctcca gcccgccctg ttgtctcctg 421 ccaagcagcc gactatgaga acttctcttg cacttggagt cccagccaga tcagcggttt

481 acccacccgc tacctcacct cctacaggaa gaagacagtc ctaggagctg atagccagag

541 gaggagtcca tccacagggc cctggccatg cccacaggat cccctagggg ctgcccgctg

601 tgttgtccac ggggctgagt tctggagcca gtaccggatt aatgtgactg aggtgaaccc

661 actgggtgcc agcacacgcc tgctggatgt gagcttgcag agcatcttgc gccctgaccc

721 accccagggc ctgcgggtag agtcagtacc aggttacccc cgacgcctgc gagccagctg

781 gacataccct gcctcctggc cgtgccagcc ccacttcctg ctcaagttcc gtttgcagta

841 ccgtccggcg cagcatccag cctggtccac ggtggagcca gctggactgg aggaggtgat

901 cacagatgct gtggctgggc tgccccatgc tgtacgagtc agtgcccggg actttctaga

961 tgctggcacc tggagcacct ggagcccgga ggcctgggga actccgagca ctgggaccat

1021 accaaaggag ataccagcat ggggccagct acacacgcag ccagaggtgg agcctcaggt

1081 ggacagccct gctcctccaa ggccctccct ccaaccacac cctcggctac ttgatcacag

1141 ggactctgtg gagcaggtag ctgtgctggc gtctttggga atcctttctt tcctgggact

1201 ggtggctggg gccctggcac tggggctctg gctgaggctg agacggggtg ggaaggatgg

1261 atccccaaag cctgggttct tggcctcagt gattccagtg gacaggcgtc caggagctcc

1321 aaacctgtag aggacccagg agggcttcgg cagattccac ctataattct gtcttgctgg

1381 tgtggataga aaccaggcag gacagtagat ccctatggtt ggatctcagc tggaagttct

1441 gtttggagcc catttctgtg agaccctgta tttcaaattt gcagctgaaa ggtgcttgta

1501 cctctgattt caccccagag ttggagttct gctcaaggaa cgtgtgtaat gtgtacatct

1561 gtgtccatgt gtgaccatgt gtctgtgaag gccagggaac atgtattcct ctgcatgcat

1621 gtatgtaggt gcctgggagt gtgtgtggtc cttgctctgg ccctttccct tgcagggttg

1681 tgcaggtgtg aataaa

INFORMATION FOR SEQ ID NO: 72: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1682 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single EPI-109 1241

(D) TOPOLOGY: linear 'xι)SEQUENCE DESCRIPTION: SEQ ID :!0:72: 1 ggaagatgag cagcagctgc tcagggctga gcagggtcct ggtggccgtg gctacagccc

61 tggtgtctgc ctcctccccc tgcccccagg cctggggccc cccaggggtc cagtatgggc

121 agccaggcag gtccgtgaag ctgtgttgtc ctggagtgac tgccggggac ccagtgtcct

181 ggtttcggga tggggagcca aagctgctcc agggacctga ctctgggcta gggcatgaac

241 tggtcctggc ccaggcagac agcactgatg agggcaccta catctgccag accctggatg

301 gtgcacttgg gggcacagtg accctgcagc tgggctaccc tccagcccgc cctgttgtct

361 cctgccaagc agccgactat gagaacttct cttgcacttg gagtcccagc cagatcagcg

421 gtttacccac ccgctacctc acctcctaca ggaagaagac agtcctagga gctgatagcc

481 agaggaggag tccatccaca gggccctggc catgcccaca ggatccccta ggggctgccc

541 gctgtgttgt ccacggggct gagttctgga gccagtaccg gattaatgtg actgaggtga

601 acccactggg tgccagcaca cgcctgctgg atgtgagctt gcagagcatc ttgcgccctg

661 acccacccca gggcctgcgg gtagagtcag taccaggtta cccccgacgc ctgcgagcca

721 gctggacata ccctgcctcc tggccgtgcc agccccactt cctgctcaag ttccgtttgc

781 agtaccgtcc ggcgcagcat ccagcctggt ccacggtgga gccagctgga ctggaggagg

841 tgatcacaga tgctgtggct gggctgcccc atgctgtacg agtcagtgcc cgggactttc

901 tagatgctgg cacctggagc acctggagcc cggaggcctg gggaactccg agcactggga

961 ccataccaaa ggagatacca gcatggggcc agctacacac gcagccagag gtggagcctc

1021 aggtggacag ccctgctcct ccaaggccct ccctccaacc acaccctcgg ctacttgatc

1081 acagggactc tgtggagcag gtagctgtgc tggcgtcttt gggaatcctt tctttcctgg

1141 gactggtggc tggggccctg gcactggggc tctggctgag gctgagacgg ggtgggaagg

1201 atggatcccc aaagcctggg ttcttggcct cagtgattcc agtggacagg cgtccaggag

1261 ctccaaacct gtagaggacc caggagggct tcggcagatt ccacctataa ttctgtcttg

1321 ctggtgtgga tagaaaccag gcaggacagt agatccctat ggttggatct cagctggaag

1381 ttctgtttgg agcccatttc tgtgagaccc tgtatttcaa atttgcagct gaaaggtgct

1441 tctacctctg atttcacccc agagttggag ttctgctcaa ggaacgtgtg taatgtgtac

1501 atctgtgtcc atgtgtgacc atgtgtctgt gaggcaggga acatgtattc tctgcatgca

1561 tgtatgtagg tgcctgggga gtgtgtgtgg gtccttggct cttggccttt ccttgcaggg

1621 gttgtgcagg tgtgaataaa gagaataagg aagttcttgg agattatact cagaaaaaaa

1681 aa

(2) INFORMATION FOR SEQ ID NO: 73: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 413 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 73: 1 tctgtggagc aggtagctgt gctggcgtct ttgggaatcc tttctttcct gggactggtg

61 gctggggccc tggcactggg gctctggtaa gtgactgcca ttggtccctc agcctctgat 121 cctcacacat gctctgatgc ccatagacca cattcatctc cacccttcat gactgcctgc 181 tgaacctgtc tgattctgga actacctccc catacctcca tcccctatgc cccacttgat 241 tttaactgat tcctctcctg accctttact aataaaccct ttggcggaga ctgagataac 301 ccacattgtt ggagagacag ctgcctttct atgccccagg ctgaggctga gacggggtgg 361 gaaggatgga tccccaaagc ctgggttctt ggcctcagtg attccagtgg aca

(2) INFORMATION FOR SEQ ID NO: 74: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3791 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 74: gctgtagctg gtgagaggaa gtcctagagg ctatggacac tctgctgctg ggatcaccga

61 gatgagcagc agctgctcag ggctgagcag ggtcctggtg gccgtggcta cagccctggt

121 gtctgcctcc tccccctgcc cccaggcctg gggcccccca ggggtccagt atgggcagcc

181 agggaggtcc gtgaagctgt gttgtcctgg agtgactgcc ggggacccag tgtcctggtt

241 tcgggatggg gagccaaagc tgctccaggg acctgactct gggctagggc atgaactggt

301 cctggcccag gcagacagca ctgatgaggg cacctacatc tgccagaccc tggatggtgc

361 acttgggggc acagtgaccc tgcagctggg ctaccctcca gcccgccctg ttgtctcctg

421 ccaagcagcc gactatgaga acttctcttg cacttggagt cccagccaga tcagcggttt

481 acccacccgc tacctcacct cctacaggaa gaagacagtc ctaggagctg atagccagag

541 gaggagtcca tccacagggc cctggccatg cccacaggat cccctagggg ctgcccgctg

601 tgttgtccac ggggctgagt tctggagcca gtaccggatt aatgtgactg aggtgaaccc

661 actgggtgcc agcacacgcc tgctggatgt gagcttgcag agcatcttgc gccctgaccc

721 accccagggc ctgcgggtag agtcagtacc aggttacccc cgacgcctgc gagccagctg

781 gacataccct gcctcctggc cgtgccagcc ccacttcctg ctcaagttcc gtttgcagta

841 ccgtccggcg cagcatccag cctggtccac ggtggagcca gctggactgg aggaggtgat

901 cacagatgct gtggctgggc tgccccatgc tgtacgagtc agtgcccggg actttctaga

961 tgctggcacc tggagcacct ggagcccgga ggcctgggga actccgagca ctgggaccat

1021 accaaaggag ataccagcat ggggccagct acacacgcag ccagaggtgg agcctcaggt

1081 ggacagccct gctcctccaa ggccctccct ccaaccacac cctcggctac ttgatcacag

1141 ggactctgtg gagcaggtag ctgtgctggc gtctttggga atcctttctt tcctgggact

1201 ggtggctggg gccctggcac tggggctctg gctgaggctg agacggggtg ggaaggatgg EPI-109 1242

1261 atccccaaag cctgggttct tggcctcagt gattccagtg gacaggcgtc caggagctcc

1321 aaacctgtag aggacccagg agggcttcgg cagattccac ctataattct gtcttgctgg

1381 tgtggataga aaccaggcag gacagtagat ccctatggtt ggatctcagc tggaagttct

1441 gtttggagcc catttctgtg agaccctgta tttcaaattt gcagctgaaa ggtgcttgta

1501 cctctgattt caccccagag ttggagttct gctcaaggaa cgtgtgtaat gtgtacatct

1561 gtgtccatgt gtgaccatgt gtctgtgaag gccagggaac atgtattcct ctgcatgcat

1621 gtatgtaggt gcctgggagt gtgtgtggtc cttgctctgg ccctttccct tgcagggttg

1681 tgcaggtgtg aataaa

1 ggaagatgag cagcagctgc tcagggctga gcagggtcct ggtggccgtg gctacagccc

61 tggtgtctgc ctcctccccc tgcccccagg cctggggccc cccaggggtc cagtatgggc

121 agccaggcag gtccgtgaag ctgtgttgtc ctggagtgac tgccggggac ccagtgtcct

181 ggtttcggga tggggagcca aagctgctcc agggacctga ctctgggcta gggcatgaac

241 tggtcctggc ccaggcagac agcactgatg agggcaccta catctgccag accctggatg

301 gtgcacttgg gggcacagtg accctgcagc tgggctaccc tccagcccgc cctgttgtct

361 cctgccaagc agccgactat gagaacttct cttgcacttg gagtcccagc cagatcagcg

421 gtttacccac ccgctacctc acctcctaca ggaagaagac agtcctagga gctgatagcc

481 agaggaggag tccatccaca gggccctggc catgcccaca ggatccccta ggggctgccc

541 gctgtgttgt ccacggggct gagttctgga gccagtaccg gattaatgtg actgaggtga

601 acccactggg tgccagcaca cgcctgctgg atgtgagctt gcagagcatc ttgcgccctg

661 acccacccca gggcctgcgg gtagagtcag taccaggtta cccccgacgc ctgcgagcca

721 gctggacata ccctgcctcc tggccgtgcc agccccactt cctgctcaag ttccgtttgc

781 agtaccgtcc ggcgcagcat ccagcctggt ccacggtgga gccagctgga ctggaggagg

841 tgatcacaga tgctgtggct gggctgcccc atgctgtacg agtcagtgcc cgggactttc

901 tagatgctgg cacctggagc acctggagcc cggaggcctg gggaactccg agcactggga

961 ccataccaaa ggagatacca gcatggggcc agctacacac gcagccagag gtggagcctc

1021 aggtggacag ccctgctcct ccaaggccct ccctccaacc acaccctcgg ctacttgatc

1081 acagggactc tgtggagcag gtagctgtgc tggcgtcttt gggaatcctt tctttcctgg

1141 gactggtggc tggggccctg gcactggggc tctggctgag gctgagacgg ggtgggaagg

1201 atggatcccc aaagcctggg ttcttggcct cagtgattcc agtggacagg cgtccaggag

1261 ctccaaacct gtagaggacc caggagggct tcggcagatt ccacctataa ttctgtcttg

1321 ctggtgtgga tagaaaccag gcaggacagt agatccctat ggttggatct cagctggaag

1381 ttctgtttgg agcccatttc tgtgagaccc tgtatttcaa atttgcagct gaaaggtgct

1441 tctacctctg atttcacccc agagttggag ttctgctcaa ggaacgtgtg taatgtgtac

1501 atctgtgtcc atgtgtgacc atgtgtctgt gaggcaggga acatgtattc tctgcatgca

1561 tgtatgtagg tgcctgggga gtgtgtgtgg gtccttggct cttggccttt ccttgcaggg

1621 gttgtgcagg tgtgaataaa gagaataagg aagttcttgg agattatact cagaaaaaaa

1681 aa

1 tctgtggagc aggtagctgt gctggcgtct ttgggaatcc tttctttcct gggactggtg 61 gctggggccc tggcactggg gctctggtaa gtgactgcca ttggtccctc agcctctgat 121 cctcacacat gctctgatgc ccatagacca cattcatctc cacccttcat gactgcctgc 181 tgaacctgtc tgattctgga actacctccc catacctcca tcccctatgc cccacttgat 241 tttaactgat tcctctcctg accctttact aataaaccct ttggcggaga ctgagataac 301 ccacattgtt ggagagacag ctgcctttct atgccccagg ctgaggctga gacggggtgg 361 gaaggatgga tccccaaagc ctgggttctt ggcctcagtg attccagtgg aca

(2) INFORMATION FOR SEQ ID NO:75: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 762 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 75: 1 atgtggcccc ctgggtcagc ctcccagcca ccgccctcac ctgccgcggc cacaggtctg

61 catccagcgg ctcgccctgt gtccctgcag tgccggctca gcatgtgtcc agcgcgcagc 121 ctcctccttg tggctaccct ggtcctcctg gaccacctca gtttggccag aaacctcccc 181 gtggccactc cagacccagg aatgttccca tgccttcacc actcccaaaa cctgctgagg 241 gccgtcagca acatgctcca gaaggccaga caaactctag aattttaccc ttgcacttct 301 gaagagattg atcatgaaga tatcacaaaa gataaaacca gcacagtgga ggcctgttta 361 ccattggaat taaccaagaa tgagagttgc ctaaattcca gagagacctc tttcataact 421 aatgggagtt gcctggcctc cagaaagacc tcttttatga tggccctgtg ccttagtagt 481 atttatgaag acttgaagat gtaccaggtg gagttcaaga ccatgaatgc aaagcttctg 541 atggatccta agaggcagat ctttctagat caaaacatgc tggcagttat tgatgagctg 601 atgcaggccc tgaatttcaa cagtgagact gtgccacaaa aatcctccct tgaagaaccg 661 gatttttata aaactaaaat caagctctgc atacttcttc atgctttcag aattcgggca 721 gtgactattg atagagtgat gagctatctg aatgcttcct aa

(2) INFORMATION FOR SEQ ID NO: 76: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2056 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:76: 1 aagcttcttt tgcataactg gcgctggatt tttactgaga ctttacgtta cagttttttt

61 tttttaaatt tcaaggtgct tttacgaaca catgaataaa atatttgtgt cattttgaac EPI-109 1243

121 cttacttgtc ttattttatg catgtattta tttatggggg ggcacaagga ctcatctgtg

181 gtggtgcagc cactgtaaat aaattagtga aactacttca cgtcaatttc tgttcagtac

241 actttagtga tggatcggag gaaattaata catgtttaca aaaagcccct cccccagttg

301 ttacatatgc ctcagagata ccagttgtga aaagtgcagg tgcacttaca cacatacgca

361 cacacacccc acaaatggta tcatacgaaa aaacatacct gcaatctgat ttgtccactt

421 aattgtatat cttggataca gaacttgttt cactggaagg ctaaaaggca aagtctgggg

481 aggcctagag gacacagggg atgggaggag gcgctctgag ctggatgtaa ggtctccacc

541 cacggccaga gcacaaggtc ggataaccag tgggcctgcc ggcttggctg cctgggccct

601 cccctgccga gacaaacggc tggagggagg aagtgtgcgg ctgggaagct ccgctgctct

661 ggcccgggtt tcccatttcc cccttcccgc gctgagacgg cgaggaaagt tagcccggaa

721 atctgcgccc gcctaaaacc cggcctggtc ccagccaccg ccccaggaac ttcccccacc

781 gcaggggcgg aggtcgagag cagggatgga gaagtggacc tgcgcgggtg gactccgggg

841 cgcgggtgga ctccggggcg cggggggact ccgaggagcg ggtggactgt ggggcgcggg

901 taccgtctcg cagcgacctc tgtcggcggc tctggggatg gcccgcatct gtctgcgtgt

961 acctggtata cgtgcaggta catgttcctg ttcacgtgca gactgggcgg gggatggggg

1021 ggtccacacc ggtgtacacc tttgcatacc tcttagcaac ttgaaattcc accacgagag

1081 atatctttat tccgctattc ctgtgcatct gcacggagcc cctagggcca tagatttgtg

1141 tgcaaatgaa atgaggatgt agtctgggtg cccaaggggg ggtgccttga gtgtggttgt

1201 ctgtatgcct ccctgagggt atttcacttt ctgctcccat ccgcccctat gagcgagtac

1261 ctatgagcac aggatgtgca catatttgag tcttattagt ggtacacgca gttttatcat

1321 ctccccaggt ctgtgtctgt atgaaatgtg catgggtgtg tgtgtgcacg cgtgtgttcc

1381 cactcgggga atgtggggag aggtgcatgg agccaagatg ggtggtaaat agtatgtttc

1441 tgaaattaaa ggactaatgt ggaggaaggc gccccagatg tactaaaccc tttgccttca

1501 tctcatcctc tctgacttgg gaagaaccag gattttgttt ttaagccctt gggcatacag

1561 ttgttccatc ccgacatgaa ctcagcctcc cgtctgaccg ccccttggcc ttccttcttc

1621 ctcgatctgt ggaacccagg gaatctgcct agtgctgtct ccaagcacct tggccatgat

1681 gtaaacccag agaaattagc atctccatct ccttccttat tccccaccca aaagtcattt

1741 cctcttagtt cattacctgg gattttgatg tctatgttcc ctcctcgtta ttgatacaca

1801 cacagagaga gacaaacaaa aaaggaactt cttgaaattc ccccagaagg ttttgagagt

1861 tgttttcaat gttgcaacaa gtcagtttct agtttaagtt tccatcagaa aggagtagag

1921 tatataagtt ccagtaccag caacagcagc agaagaaaca acatctgttt cagggccatt

1981 ggactctccg tcctgcccag agcaaggtaa gcacttccca agcccctacc tccctcccct

2041 ccctgtgggc ctgcag

(2) INFORMATION FOR SEQ ID NO: 77: (i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 1703 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi)SEQUENCE DESCRIPTION: SEQ ID NO:77: gaattctcag acagcagcat tagaaggggc cttagagatc aaccatttct cttattttac

61 acacacctaa aactccctac agccgtgctt catcagcttc gagcagatga gccacccaga

121 aggcagctcc agttattagg tcctagggcc tgggtgtagt caggcccttt ggaagctcca

181 agtcagagat caaacacatc ctccccacta cccacgccta gggtgactaa tgcctgtggg

241 aaaaacaact gaactaaaaa gtcccacagg aacctcaaac ccagcacatc caaaatggaa

301 cttctcacca tctcctccaa actcagtcct cttatacagt aatccctgta aagctagaac

361 aatctccatt ccccattctc agggccttcc tctcccgctc acctgaggag ctaccaagcc

421 ttggcccaca agccctctga gagtccctcc tgcccaccct gtgttctcca tactgaataa

481 ggacttggcc acaccttgtc aactcttccc tctgctctac tcctgacccc tggatccccc

541 catcatgcaa attctgccac atctcccgcc taaaacccag gaagactccc cactactctc

601 agcacagaaa gtacactcct tagtatggca tcccctgccc tcatggcatg gcccatccag

661 ccctccagcc tcacaccctg caaggacacc tagaccccca cctccctcaa cccttcatga

721 ctgcgcttct gatccctgtt tcccctggct agaccctgcg tgccctcccg ctggaagcgg

781 tctaatgcct gcttgttttt aacactcagg ttggggcccc tgcctgctcc cgggagcctt

841 tgctgactcc tggaccccgt tgctccggct gagcgtgggc tctttctcta ggtctttcct

901 cccaggactc tgtgtattca tcctatcgtt aaactggatt ctctacaaga gtaataattg

961 cagagtcagc cagctctcat cccttttcag gtttcagaaa agacctgtga acaaaacgcc

1021 ttgagtctga tttagtgtgg caatgcccca agggtcctgt tctccctggg tgtcctgcac

1081 ctggtgcaac gtcggcctgg catctagtga gccatctaaa ggaacgatga tgagtgaatg

1141 atttgcctac cccttccagt actaggctgg aggtcgtggt tagggcccat ccctacgcag

1201 gacatgcaaa gtgggaggca ctcctctctc tacgtcggca gggggcgctg cacagctgcg

1261 gggcggggta gcttagacac ggggcgtccg gctaaggccg gggacccagg gtggtgggcg

1321 gggtgtcccg cccgcctgtg gaccccgcgc agtaactgcg aacatttcgc tttcattttg

1381 ggccgagctg gaggcggcgg ggccgtcccg gaacggctgc ggccgggcac cccgggagtt

1441 aatccgaaag cgccgcaagc ccccggggcc ggccgcaccg cacgtgtcac cgagaagctg

1501 atgtagagag agacacagaa ggagacagaa agcaagagac cagagtcccg ggaaagtcct

1561 gccgcgcctc gggacaatta taaaaatgtg gccccctggg tcagcctccc agccaccgcc

1621 ctcacctgcc gcggccacag gtctgcatcc agcggctcgc cctgtgtccc tgcagtgccg

1681 gctcagcatg tgtccagcgc gca

(2) INFORMATION FOR SEQ ID NO: 78: (1) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4521 base pairs

(B) TYPE: nucleic acid EPI-109 1244

<C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 78: 1 atgtggcccc ctgggtcagc ctcccagcca ccgccctcac ctgccgcggc cacaggtctg

61 catccagcgg ctcgccctgt gtccctgcag tgccggctca gcatgtgtcc agcgcgcagc 121 ctcctccttg tggctaccct ggtcctcctg gaccacctca gtttggccag aaacctcccc 181 gtggccactc cagacccagg aatgttccca tgccttcacc actcccaaaa cctgctgagg 241 gccgtcagca acatgctcca gaaggccaga caaactctag aattttaccc ttgcacttct 301 gaagagattg atcatgaaga tatcacaaaa gataaaacca gcacagtgga ggcctgttta 361 ccattggaat taaccaagaa tgagagttgc ctaaattcca gagagacctc tttcataact 421 aatgggagtt gcctggcctc cagaaagacc tcttttatga tggccctgtg ccttagtagt 481 atttatgaag acttgaagat gtaccaggtg gagttcaaga ccatgaatgc aaagcttctg 541 atggatccta agaggcagat ctttctagat caaaacatgc tggcagttat tgatgagctg 601 atgcaggccc tgaatttcaa cagtgagact gtgccacaaa aatcctccct tgaagaaccg 661 gatttttata aaactaaaat caagctctgc atacttcttc atgctttcag aattcgggca 721 gtgactattg atagagtgat gagctatctg aatgcttcct aa 1 aagcttcttt tgcataactg gcgctggatt tttactgaga ctttacgtta cagttttttt

61 tttttaaatt tcaaggtgct tttacgaaca catgaataaa atatttgtgt cattttgaac

121 cttacttgtc ttattttatg catgtattta tttatggggg ggcacaagga ctcatctgtg

181 gtggtgcagc cactgtaaat aaattagtga aactacttca cgtcaatttc tgttcagtac

241 actttagtga tggatcggag gaaattaata catgtttaca aaaagcccct cccccagttg

301 ttacatatgc ctcagagata ccagttgtga aaagtgcagg tgcacttaca cacatacgca

361 cacacacccc acaaatggta tcatacgaaa aaacatacct gcaatctgat ttgtccactt

421 aattgtatat cttggataca gaacttgttt cactggaagg ctaaaaggca aagtctgggg

481 aggcctagag gacacagggg atgggaggag gcgctctgag ctggatgtaa ggtctccacc

541 cacggccaga gcacaaggtc ggataaccag tgggcctgcc ggcttggctg cctgggccct

601 cccctgccga gacaaacggc tggagggagg aagtgtgcgg ctgggaagct ccgctgctct

661 ggcccgggtt tcccatttcc cccttcccgc gctgagacgg cgaggaaagt tagcccggaa

721 atctgcgccc gcctaaaacc cggcctggtc ccagccaccg ccccaggaac ttcccccacc

781 gcaggggcgg aggtcgagag cagggatgga gaagtggacc tgcgcgggtg gactccgggg

841 cgcgggtgga ctccggggcg cggggggact ccgaggagcg ggtggactgt ggggcgcggg

901 taccgtctcg cagcgacctc tgtcggcggc tctggggatg gcccgcatct gtctgcgtgt

961 acctggtata cgtgcaggta catgttcctg ttcacgtgca gactgggcgg gggatggggg

1021 ggtccacacc ggtgtacacc tttgcatacc tcttagcaac ttgaaattcc accacgagag

1081 atatctttat tccgctattc ctgtgcatct gcacggagcc cctagggcca tagatttgtg

1141 tgcaaatgaa atgaggatgt agtctgggtg cccaaggggg ggtgccttga gtgtggttgt

1201 ctgtatgcct ccctgagggt atttcacttt ctgctcccat ccgcccctat gagcgagtac

1261 ctatgagcac aggatgtgca catatttgag tcttattagt ggtacacgca gttttatcat

1321 ctccccaggt ctgtgtctgt atgaaatgtg catgggtgtg tgtgtgcacg cgtgtgttcc

1381 cactcgggga atgtggggag aggtgcatgg agccaagatg ggtggtaaat agtatgtttc

1441 tgaaattaaa ggactaatgt ggaggaaggc gccccagatg tactaaaccc tttgccttca

1501 tctcatcctc tctgacttgg gaagaaccag gattttgttt ttaagccctt gggcatacag

1561 ttgttccatc ccgacatgaa ctcagcctcc cgtctgaccg ccccttggcc ttccttcttc

1621 ctcgatctgt ggaacccagg gaatctgcct agtgctgtct ccaagcacct tggccatgat

1681 gtaaacccag agaaattagc atctccatct ccttccttat tccccaccca aaagtcattt

1741 cctcttagtt cattacctgg gattttgatg tctatgttcc ctcctcgtta ttgatacaca

1801 cacagagaga gacaaacaaa aaaggaactt cttgaaattc ccccagaagg ttttgagagt

1861 tgttttcaat gttgcaacaa gtcagtttct agtttaagtt tccatcagaa aggagtagag

1921 tatataagtt ccagtaccag caacagcagc agaagaaaca acatctgttt cagggccatt

1981 ggactctccg tcctgcccag agcaaggtaa gcacttccca agcccctacc tccctcccct

2041 ccctgtgggc ctgcag gaattctcag acagcagcat tagaaggggc cttagagatc aaccatttct cttattttac

61 acacacctaa aactccctac agccgtgctt catcagcttc gagcagatga gccacccaga 121 aggcagctcc agttattagg tcctagggcc tgggtgtagt caggcccttt ggaagctcca 181 agtcagagat caaacacatc ctccccacta cccacgccta gggtgactaa tgcctgtggg 241 aaaaacaact gaactaaaaa gtcccacagg aacctcaaac ccagcacatc caaaatggaa 301 cttctcacca tctcctccaa actcagtcct cttatacagt aatccctgta aagctagaac 361 aatctccatt ccccattctc agggccttcc tctcccgctc acctgaggag ctaccaagcc 421 ttggcccaca agccctctga gagtccctcc tgcccaccct gtgttctcca tactgaataa 481 ggacttggcc acaccttgtc aactcttccc tctgctctac tcctgacccc tggatccccc 541 catcatgcaa attctgccac atctcccgcc taaaacccag gaagactccc cactactctc 601 agcacagaaa gtacactcct tagtatggca tcccctgccc tcatggcatg gcccatccag 661 ccctccagcc tcacaccctg caaggacacc tagaccccca cctccctcaa cccttcatga 721 ctgcgcttct gatccctgtt tcccctggct agaccctgcg tgccctcccg ctggaagcgg 781 tctaatgcct gcttgttttt aacactcagg ttggggcccc tgcctgctcc cgggagcctt 841 tgctgactcc tggaccccgt tgctccggct gagcgtgggc tctttctcta ggtctttcct 901 cccaggactc tgtgtattca tcctatcgtt aaactggatt ctctacaaga gtaataattg 961 cagagtcagc cagctctcat cccttttcag gtttcagaaa agacctgtga acaaaacgcc EPI-109 1245

1021 ttgagtctga tttagtgtgg caatgcccca agggtcctgt tctccctggg tgtcctgcac

1081 ctggtgcaac gtcggcctgg catctagtga gccatctaaa ggaacgatga tgagtgaatg

1141 atttgcctac cccttccagt actaggctgg aggtcgtggt tagggcccat ccctacgcag

1201 gacatgcaaa gtgggaggca ctcctctctc tacgtcggca gggggcgctg cacagctgcg

1261 gggcggggta gcttagacac ggggcgtccg gctaaggccg gggacccagg gtggtgggcg

1321 gggtgtcccg cccgcctgtg gaccccgcgc agtaactgcg aacatttcgc tttcattttg

1381 ggccgagctg gaggcggcgg ggccgtcccg gaacggctgc ggccgggcac cccgggagtt

1441 aatccgaaag cgccgcaagc ccccggggcc ggccgcaccg cacgtgtcac cgagaagctg

1501 atgtagagag agacacagaa ggagacagaa agcaagagac cagagtcccg ggaaagtcct

1561 gccgcgcctc gggacaatta taaaaatgtg gccccctggg tcagcctccc agccaccgcc

1621 ctcacctgcc gcggccacag gtctgcatcc agcggctcgc cctgtgtccc tgcagtgccg

1681 gctcagcatg tgtccagcgc gca

(2) INFORMATION FOR SEQ ID NO: 79: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1742 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:79: 1 caagcccaga gccctgccat ttctgtgggc tcaggtccct actgctcagc cccttcctcc

61 ctcggcaagg ccacaatgaa ccggggagtc ccttttaggc acttgcttct ggtgctgcaa

121 ctggcgctcc tcccagcagc cactcaggga aagaaagtgg tgctgggcaa aaaaggggat

181 acagtggaac tgacctgtac agcttcccag aagaagagca tacaattcca ctggaaaaac

241 tccaaccaga taaagattct gggaaatcag ggctccttct taactaaagg tccatccaag

301 ctgaatgatc gcgctgactc aagaagaagc ctttgggacc aaggaaactt ccccctgatc

361 atcaagaatc ttaagataga agactcagat acttacatct gtgaagtgga ggaccagaag

421 gaggaggtgc aattgctagt gttcggattg actgccaact ctgacaccca cctgcttcag

481 gggcagagcc tgaccctgac cttggagagc ccccctggta gtagcccctc agtgcaatgt

541 aggagtccaa ggggtaaaaa catacagggg gggaagaccc tctccgtgtc tcagctggag

601 ctccaggata gtggcacctg gacatgcact gtcttgcaga accagaagaa ggtggagttc

661 aaaatagaca tcgtggtgct agctttccag aaggcctcca gcatagtcta taagaaagag

721 ggggaacagg tggagttctc cttcccactc gcctttacag ttgaaaagct gacgggcagt

781 ggcgagctgt ggtggcaggc ggagagggct tcctcctcca agtcttggat cacctttgac

841 ctgaagaaca aggaagtgtc tgtaaaacgg gttacccagg accctaagct ccagatgggc

901 aagaagctcc cgctccacct caccctgccc caggccttgc ctcagtatgc tggctctgga

961 aacctcaccc tggcccttga agcgaaaaca ggaaagttgc atcaggaagt gaacctggtg

1021 gtgatgagag ccactcagct ccagaaaaat ttgacctgtg aggtgtgggg acccacctcc

1081 cctaagctga tgctgagctt gaaactggag aacaaggagg caaaggtctc gaagcgggag

1141 aaggcggtgt gggtgctgaa ccctgaggcg gggatgtggc agtgtctgct gagtgactcg

1201 ggacaggtcc tgctggaatc caacatcaag gttctgccca catggtccac cccggtgcag

1261 ccaatggccc tgattgtgct ggggggcgtc gccggcctcc tgcttttcat tgggctaggc

1321 atcttcttct gtgtcaggtg ccggcaccga aggcgccaag cagagcggat gtctcagatc

1381 aagagactcc tcagtgagaa gaagacctgc cagtgccctc accggtttca gaagacatgt

1441 agccccattt gaggcacgag gccaggcaga tcccacttgc agcctcccca ggtgtctgcc

1501 ccgcgtttcc tgcctgcgga ccagatgaat gtagcagatc ccacgctctg gcctcctgtt

1561 cgtcctccct acaatttgcc attgtttctc ctgggttagg ccccggcttc actggttgag

1621 tgttgctctc tagtttccag aggcttaatc acaccgtcct ccacgccatt tccttttcct

1681 tcaagcctag cccttctctc attatttctc tctgaccctc tccccactgc tcatttggat

1741 cc

(2) INFORMATION FOR SEQ ID NO: 80: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 237 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 80: ctgccaactc tgacacccac ctgcttcagg ggcagagcct gaccctgacc ttggagagcc

61 cccctggtag tagcccctca gtgcaatgta ggagtccaag gggtaaaaac atacaggggg 121 ggaagaccct ctccgtgtct cagctggagc tccaggatag tggcacctgg acatgcactg 181 ttttgcagaa ccagaagaag gtggagttca aaatagacat cgtggtgcta gctttcc

(2) INFORMATION FOR SEQ ID NO: 81: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4040 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi)SEQUENCE DESCRIPTION: SEQ ID NO:81: tgcagagaac agagaaagga catctgcgag gaaagttccc tgatggctgt caacaaagtg

61 ccacgtctct atggctgtgt acgctgagca cacgatttta tcgcgcctat catatcttgg 121 tgcataaacg cacctcacct cggtcaaccc ttgctccgtc ttatgagaca ggctttatta 181 tccgcatttt atatgagggg aatctgacgg tggagagaga attatcttgc tcaaggcgac EPI-109 1246

241 acagcagagc ccacaggtgg cagaatccca cccgagcccg cttcgacccg cggggtggaa 301 accacgggcg cccgcccggc tgcgcttcca gagctgaact gagaagcgag tcctctccgc 361 cctgcggcca ccgcccagcc ccgacccccg ccccggcccg atcctcactc gccgccagct 421 ccccgcgccc accccggagt tggtggcgca gaggcgggag gcggaggcgg gagggcgggc 481 gctggcaccg ggaacgcccg agcgccggca gagagcgcgg agagcgcgac acgtgcggcc 541 cagagcaccg gggccacccg gtccccgcag gcccgggacc gcgcccgctg gcaggcgaca 601 cgtggaagaa tacggagttc tataccagag ttgattgttg atggcacata cttttagagg 661 atgctcattg gcatttatgt ttataatcac gtggctgttg attaaagcaa aaatagatgc 721 gtgcaagaga ggcgatgtga ctgtgaagcc ttcccatgta attttacttg gatccactgt 781 caatattaca tgctctttga agcccagaca aggctgcttt cactattcca gacgtaacaa 841 gttaatcctg tacaagtttg acagaagaat caattttcac catggccact ccctcaattc 901 tcaagtcaca ggtcttcccc ttggtacaac cttgtttgtc tgcaaactgg cctgtatcaa 961 tagtgatgaa attcaaatat gtggagcaga gatcttcgtt ggtgttgctc cagaacagcc 1021 tcaaaattta tcctgcatac agaagggaga acaggggact gtggcctgca cctgggaaag 1081 aggacgagac acccacttat acactgagta tactctacag ctaagtggac caaaaaattt 1141 aacctggcag aagcaatgta aagacattta ttgtgactat ttggactttg gaatcaacct 1201 cacccctgaa tcacctgaat ccaatttcac agccaaggtt actgctgtca atagtcttgg 1261 aagctcctct tcacttccat ccacattcac attcttggac atagtgaggc ctcttcctcc 1321 gtgggacatt agaatcaaat ttcaaaaggc ttccgtgagc agatgtaccc tttattggag 1381 agatgaggga ctggtactgc ttaatcgact cagatatcgg cccagtaaca gcaggctctg 1441 gaatatggtt aatgttacaa aggccaaagg aagacatgat ttgctggatc tgaaaccatt 1501 tacagaatat gaatttcaga tttcctctaa gctacatctt tataagggaa gttggagtga 1561 ttggagtgaa tcattgagag cacaaacacc agaagaagag cctactggga tgttagatgt 1621 ctggtacatg aaacggcaca ttgactacag tagacaacag atttctcttt tctggaagaa 1681 tctgagtgtc tcagaggcaa gaggaaaaat tctccactat caggtgacct tgcaggagct 1741 gacaggaggg aaagccatga cacagaacat cacaggacac acctcctgga ccacagtcat 1801 tcctagaacc ggaaattggg ctgtggctgt gtctgcagca aattcaaaag gcagttctct 1861 gcccactcgt attaacataa tgaacctgtg tgaggcaggg ttgctggctc ctcgccaggt 1921 ctctgcaaac tcagagggca tggacaacat tctggtgact tggcagcctc ccaggaaaga 1981 tccctctgct gttcaggagt acgtggtgga atggagagag ctccatccag ggggtgacac 2041 acaggtccct ctaaactggc tacggagtcg accctacaat gtgtctgctc tgatttcaga 2101 gaacataaaa tcctacatct gttatgaaat ccgtgtgtat gcactctcag gggatcaagg 2161 aggatgcagc tccatcctgg gtaactctaa gcacaaagca ccactgagtg gcccccacat 2221 taatgccatc acagaggaaa aggggagcat tttaatttca tggaacagca ttccagtcca 2281 ggagcaaatg ggctgcctcc tccattatag gatatactgg aaggaacggg actccaactc 2341 ccagcctcag ctctgtgaaa ttccctacag agtctcccaa aattcacatc caataaacag 2401 cctgcagccc cgagtgacat atgtcctgtg gatgacagct ctgacagctg ctggtgaaag 2461 ttcccacgga aatgagaggg aattttgtct gcaaggtaaa gccaattgga tggcgtttgt 2521 ggcaccaagc atttgcattg ctatcatcat ggtgggcatt ttctcaacgc attacttcca 2581 gcaaaaggtg tttgttctcc tagcagccct cagacctcag tggtgtagca gagaaattcc 2641 agatccagca aatagcactt gcgctaagaa atatcccatt gcagaggaga agacacagct 2701 gcccttggac aggctcctga tagactggcc cacgcctgaa gatcctgaac cgctggtcat 2761 cagtgaagtc cttcatcaag tgaccccagt tttcagacat cccccctgct ccaactggcc 2821 acaaagggaa aaaggaatcc aaggtcatca ggcctctgag aaagacatga tgcacagtgc 2881 ctcaagccca ccacctccaa gagctctcca agctgagagc agacaactgg tggatctgta 2941 caaggtgctg gagagcaggg gctccgaccc aaagccagaa aacccagcct gtccctggac 3001 ggtgctccca gcaggtgacc ttcccaccca tgatggctac ttaccctcca acatagatga 3061 cctcccctca catgaggcac ctctcgctga ctctctggaa gaactggagc ctcagcacat 3121 ctccctttct gttttcccct caagttctct tcacccactc accttctcct gtggtgataa 3181 gctgactctg gatcagttaa agatgaggtg tgactccctc atgctctgag tggtgaggct 3241 tcaagcctta aagtcagtgt gccctcaacc agcacagcct gccccaattc ccccagcccc 3301 tgctccagca gctgtcatct ctgggtgcca ccatcggtct ggctgcagct agaggacagg 3361 caagccagct ctgggggagt cttaggaact gggagttggt cttcactcag atgcctcatc 3421 ttgcctttcc cagggcctta aaattacatc cttcactgtg tggacctaga gactccaact 3481 tgaattccta gtaactttct tggtatgctg gccagaaagg gaaatgagga ggagagtaga 3541 aaccacagct cttagtagta atggcataca gtctagagga ccattcatgc aatgactatt 3601 tctaaagcac ctgctacaca gcaggctgta cacagcagat cagtactgtt caacagaact 3661 tcctgagatg atggaaatgt tctacctctg cactcactgt ccagtacatt agacactagg 3721 cacattggct gttaatcact tggaatgtgt ttagcttgac tgaggaatta aattttgatt 3781 gtaaatttaa atcgccacac atggctagtg gctactgtat tggagtgcac agctctagat 3841 ggctcctaga ttattgagag cctccaaaac aaatcaacct agttctatag atgaagacat 3901 aaaagacact ggtaaacacc aatgtaaaag ggcccccaag gtggtcatga ctggtctcat 3961 ttgcagaagt ctaagaatgt acctttttct ggccgggcgt ggtagctcat gcctgtaatc 4021 ccagcacttt gggaggctga

(2) INFORMATION FOR SEQ ID NO: 82: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 6019 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi)ΞEQUENCE DESCRIPTION: SEQ ID NO:82: caagcccaga gccctgccat ttctgtgggc tcaggtccct actgctcagc cccttcctcc

61 ctcggcaagg ccacaatgaa ccggggagtc ccttttaggc acttgcttct ggtgctgcaa 121 ctggcgctcc tcccagcagc cactcaggga aagaaagtgg tgctgggcaa aaaaggggat EPI-109 1247

181 acagtggaac tgacctgtac agcttcccag aagaagagca tacaattcca ctggaaaaac

241 tccaaccaga taaagattct gggaaatcag ggctccttct taactaaagg tccatccaag

301 ctgaatgatc gcgctgactc aagaagaagc ctttgggacc aaggaaactt ccccctgatc

361 atcaagaatc ttaagataga agactcagat acttacatct gtgaagtgga ggaccagaag

421 gaggaggtgc aattgctagt gttcggattg actgccaact ctgacaccca cctgcttcag

481 gggcagagcc tgaccctgac cttggagagc ccccctggta gtagcccctc agtgcaatgt

541 aggagtccaa ggggtaaaaa catacagggg gggaagaccc tctccgtgtc tcagctggag

601 ctccaggata gtggcacctg gacatgcact gtcttgcaga accagaagaa ggtggagttc

661 aaaatagaca tcgtggtgct agctttccag aaggcctcca gcatagtcta taagaaagag

721 ggggaacagg tggagttctc cttcccactc gcctttacag ttgaaaagct gacgggcagt

781 ggcgagctgt ggtggcaggc ggagagggct tcctcctcca agtcttggat cacctttgac

841 ctgaagaaca aggaagtgtc tgtaaaacgg gttacccagg accctaagct ccagatgggc

901 aagaagctcc cgctccacct caccctgccc caggccttgc ctcagtatgc tggctctgga

961 aacctcaccc tggcccttga agcgaaaaca ggaaagttgc atcaggaagt gaacctggtg

1021 gtgatgagag ccactcagct ccagaaaaat ttgacctgtg aggtgtgggg acccacctcc

1081 cctaagctga tgctgagctt gaaactggag aacaaggagg caaaggtctc gaagcgggag

1141 aaggcggtgt gggtgctgaa ccctgaggcg gggatgtggc agtgtctgct gagtgactcg

1201 ggacaggtcc tgctggaatc caacatcaag gttctgccca catggtccac cccggtgcag

1261 ccaatggccc tgattgtgct ggggggcgtc gccggcctcc tgcttttcat tgggctaggc

1321 atcttcttct gtgtcaggtg ccggcaccga aggcgccaag cagagcggat gtctcagatc

1381 aagagactcc tcagtgagaa gaagacctgc cagtgccctc accggtttca gaagacatgt

1441 agccccattt gaggcacgag gccaggcaga tcccacttgc agcctcccca ggtgtctgcc

1501 ccgcgtttcc tgcctgcgga ccagatgaat gtagcagatc ccacgctctg gcctcctgtt

1561 cgtcctccct acaatttgcc attgtttctc ctgggttagg ccccggcttc actggttgag

1621 tgttgctctc tagtttccag aggcttaatc acaccgtcct ccacgccatt tccttttcct

1681 tcaagcctag cccttctctc attatttctc tctgaccctc tccccactgc tcatttggat

1741 cc

1 ctgccaactc tgacacccac ctgcttcagg ggcagagcct gaccctgace ttggagagcc

61 cccctggtag tagcccctca gtgcaatgta ggagtccaag gggtaaaaac atacaggggg

121 ggaagaccct ctccgtgtct cagctggagc tccaggatag tggcacctgg acatgcactg

181 ttttgcagaa ccagaagaag gtggagttca aaatagacat cgtggtgcta gctttcc

1 tgcagagaac agagaaagga catctgcgag gaaagttccc tgatggctgt caacaaagtg

61 ccacgtctct atggctgtgt acgctgagca cacgatttta tcgcgcctat catatcttgg

121 tgcataaacg cacctcacct cggtcaaccc ttgctccgtc ttatgagaca ggctttatta

181 tccgcatttt atatgagggg aatctgacgg tggagagaga attatcttgc tcaaggcgac

241 acagcagagc ccacaggtgg cagaatccca cccgagcccg cttcgacccg cggggtggaa

301 accacgggcg cccgcccggc tgcgcttcca gagctgaact gagaagcgag tcctctccgc

361 cctgcggcca ccgcccagcc ccgacccccg ccccggcccg atcctcactc gccgccagct

421 ccccgcgccc accccggagt tggtggcgca gaggcgggag gcggaggcgg gagggcgggc

481 gctggcaccg ggaacgcccg agcgccggca gagagcgcgg agagcgcgac acgtgcggcc

541 cagagcaccg gggccacccg gtccccgcag gcccgggacc gcgcccgctg gcaggcgaca

601 cgtggaagaa tacggagttc tataccagag ttgattgttg atggcacata cttttagagg

661 atgctcattg gcatttatgt ttataatcac gtggctgttg attaaagcaa aaatagatgc

721 gtgcaagaga ggcgatgtga ctgtgaagcc ttcccatgta attttacttg gatccactgt

781 caatattaca tgctctttga agcccagaca aggctgcttt cactattcca gacgtaacaa

841 gttaatcctg tacaagtttg acagaagaat caattttcac catggccact ccctcaattc

901 tcaagtcaca ggtcttcccc ttggtacaac cttgtttgtc tgcaaactgg cctgtatcaa

961 tagtgatgaa attcaaatat gtggagcaga gatcttcgtt ggtgttgctc cagaacagcc

1021 tcaaaattta tcctgcatac agaagggaga acaggggact gtggcctgca cctgggaaag

1081 aggacgagac acccacttat acactgagta tactctacag ctaagtggac caaaaaattt

1141 aacctggcag aagcaatgta aagacattta ttgtgactat ttggactttg gaatcaacct

1201 cacccctgaa tcacctgaat ccaatttcac agccaaggtt actgctgtca atagtcttgg

1261 aagctcctct tcacttccat ccacattcac attcttggac atagtgaggc ctcttcctcc

1321 gtgggacatt agaatcaaat ttcaaaaggc ttccgtgagc agatgtaccc tttattggag

1381 agatgaggga ctggtactgc ttaatcgact cagatatcgg cccagtaaca gcaggctctg

1441 gaatatggtt aatgttacaa aggccaaagg aagacatgat ttgctggatc tgaaaccatt

1501 tacagaatat gaatttcaga tttcctctaa gctacatctt tataagggaa gttggagtga

1561 ttggagtgaa tcattgagag cacaaacacc agaagaagag cctactggga tgttagatgt

1621 ctggtacatg aaacggcaca ttgactacag tagacaacag atttctcttt tctggaagaa

1681 tctgagtgtc tcagaggcaa gaggaaaaat tctccactat caggtgacct tgcaggagct

1741 gacaggaggg aaagccatga cacagaacat cacaggacac acctcctgga ccacagtcat

1801 tcctagaacc ggaaattggg ctgtggctgt gtctgcagca aattcaaaag gcagttctct

1861 gcccactcgt attaacataa tgaacctgtg tgaggcaggg ttgctggctc ctcgccaggt

1921 ctctgcaaac tcagagggca tggacaacat tctggtgact tggcagcctc ccaggaaaga

1981 tccctctgct gttcaggagt acgtggtgga atggagagag ctccatccag ggggtgacac

2041 acaggtccct ctaaactggc tacggagtcg accctacaat gtgtctgctc tgatttcaga

2101 gaacataaaa tcctacatct gttatgaaat ccgtgtgtat gcactctcag gggatcaagg

2161 aggatgcagc tccatcctgg gtaactctaa gcacaaagca ccactgagtg gcccccacat

2221 taatgccatc acagaggaaa aggggagcat tttaatttca tggaacagca ttccagtcca

2281 ggagcaaatg ggctgcctcc tccattatag gatatactgg aaggaacggg actccaactc

2341 ccagcctcag ctctgtgaaa ttccctacag agtctcccaa aattcacatc caataaacag

2401 cctgcagccc cgagtgacat atgtcctgtg gatgacagct ctgacagctg ctggtgaaag

2461 ttcccacgga aatgagaggg aattttgtct gcaaggtaaa gccaattgga tggcgtttgt

2521 ggcaccaagc atttgcattg ctatcatcat ggtgggcatt ttctcaacgc attacttcca

2581 gcaaaaggtg tttgttctcc tagcagccct cagacctcag tggtgtagca gagaaattcc EPI-109 1248

2641 agatccagca aatagcactt gcgctaagaa atatcccatt gcagaggaga agacacagct

2701 gcccttggac aggctcctga tagactggcc cacgcctgaa gatcctgaac cgctggtcat

2761 cagtgaagtc cttcatcaag tgaccccagt tttcagacat cccccctgct ccaactggcc

2821 acaaagggaa aaaggaatcc aaggtcatca ggcctctgag aaagacatga tgcacagtgc

2881 ctcaagccca ccacctccaa gagctctcca agctgagagc agacaactgg tggatctgta

2941 caaggtgctg gagagcaggg gctccgaccc aaagccagaa aacccagcct gtccctggac

3001 ggtgctccca gcaggtgacc ttcccaccca tgatggctac ttaccctcca acatagatga

3061 cctcccctca catgaggcac ctctcgctga ctctctggaa gaactggagc ctcagcacat

3121 ctccctttct gttttcccct caagttctct tcacccactc accttctcct gtggtgataa

3181 gctgactctg gatcagttaa agatgaggtg tgactccctc atgctctgag tggtgaggct

3241 tcaagcctta aagtcagtgt gccctcaacc agcacagcct gccccaattc ccccagcccc

3301 tgctccagca gctgtcatct ctgggtgcca ccatcggtct ggctgcagct agaggacagg

3361 caagccagct ctgggggagt cttaggaact gggagttggt cttcactcag atgcctcatc

3421 ttgcctttcc cagggcctta aaattacatc cttcactgtg tggacctaga gactccaact

3481 tgaattccta gtaactttct tggtatgctg gccagaaagg gaaatgagga ggagagtaga

3541 aaccacagct cttagtagta atggcataca gtctagagga ccattcatgc aatgactatt

3601 tctaaagcac ctgctacaca gcaggctgta cacagcagat cagtactgtt caacagaact

3661 tcctgagatg atggaaatgt tctacctctg cactcactgt ccagtacatt agacactagg

3721 cacattggct gttaatcact tggaatgtgt ttagcttgac tgaggaatta aattttgatt

3781 gtaaatttaa atcgccacac atggctagtg gctactgtat tggagtgcac agctctagat

3841 ggctcctaga ttattgagag cctccaaaac aaatcaacct agttctatag atgaagacat

3901 aaaagacact ggtaaacacc aatgtaaaag ggcccccaag gtggtcatga ctggtctcat

3961 ttgcagaagt ctaagaatgt acctttttct ggccgggcgt ggtagctcat gcctgtaatc

4021 ccagcacttt gggaggctga

(2) INFORMATION FOR SEQ ID NO: 83: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 5670 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 83: ggatccccgc tgacaatcta gaaacaagca acagaccctc tgatgtagcc atctgtgccg

61 cgcctctccg caccgcccgc cacgccttgg tccctggaga ccaccctcca gggcaggggc

121 tgccgctcgg ccgggcccgc ggggtccctc ggcctgacat ggccggtgct ggagcggcac

181 gtgcgcgcct cggcccctcg gccgctcccg cccctcgccg gtgcgcaccg gcgctcgggg

241 agccgctggc ccgggtgtcc agccggccct tgccctgcct ggcgctcgga ccgccacctt

301 tgccgccccc tcgccagcct ccgcagcttc cagactggcc ggtctgcgcg cccacccctg

361 cctcccggac cggccaccgc cggaggccgc ggaggagggc ccggccgcgc agatcccgct

421 tatcgggccc catctcccgt tacataaggc caccccccta tctccgcggg ccatcgccgc

481 cgcaaccgcc gcgccagcgc cttctcccac gcgcgggggc gcccctgccc accgctcccg

541 gcagggcttt tggtggccat gggggataag gggcgttgac tcacccgggc ggggctccgg

601 gagttgcaca gaccaaggta gttccccgct ccttccccca tcacggagac cctgtgggag

661 atgccgtggg ccctctacta cagattagga aacaggcccg tagaggggtc gcgcggccaa

721 gtagcggcac tccaggcact gggggccctc gagggaaggg gcagacttct gggagtcaga

781 gccagcagct gggctgggaa gcttcgagtg tggacagaga gggtgggaat gacgttccct

841 gtgggaagag agggtgggca agcctgggat gcctctgagc gggaatccag catgccttgt

901 gaggagggtc acaagcacac ccttgtgagg aggttgagcc ccatcgagga caggacggag

961 ggagcctgag caggcagaga gggggcctgg ggaggcgctg gttcggggag gaagtgggta

1021 ggggagaaat cttgacatca acacccaaca ggcaaatgcc gtggcctctg ctgtgggggt

1081 ttctggagga cttctaggaa aacgagggaa gagcaggaaa aggcgacatg gctgtagggc

1141 caagcccagg agccgccctc cacagcactc attctgcaga agggaaattt gaggccccca

1201 gacggcaggg gttgatcctg cagagactgg tgagcaaagg ggatcacccc aagccccagt

1261 ggcactagga acacttacaa tctctgacct ggactaaggc tgccagcctg gcccagttaa

1321 gagtttccca gaaggatggc ccatacactt taaattaaag gggccagaca cgtgcacact

1381 acttccagcc actctggaag ctgaggtggg gggatcgctt gagtctggga gttggaggcc

1441 agcctaggca ggcaacatag tgagacccca tctccaaaaa aacaaaacaa aacaaaacaa

1501 aaaaacacca aaaaagctcc cagaaagacc tctgaatctt tctggatctc tcagtggaga

1561 cctggaaatc tgaactttga caatccctct cacagtgggg ccaaggagga attaggcaag

1621 ccaaaagaag tgaactttac tcttctattg cctgtttgaa ttttgtatcc aagcaagtgt

1681 tacttaagta atttaagaga ctggttcatc gaaaaaataa aactccccaa attcccatag

1741 ctggtagact gtggtcacag ccacagtgca ctaagactat ctgctcagca cttctggtga

1801 cccaaaaggg tctgaggaca ggagctcaga gttgggtcag ctgtccaggt actcagggtt

1861 gtcacaggca aaactgctgg aactcagggc agcattgcaa atgccacgcc gctctcaggg

1921 ccccttgcct gccgctggaa ttaaacccac ccagatcttg gaaactctgc cctggaccct

1981 tctcaataag tccatgagaa atcaaactct ttcctttatg cgacactgga ttttccacaa

2041 agtaaaatca agatgagtaa agatgtggtt tctagatagt gcctgaaaaa gcagagacca

2101 tggtgtcagg cgtcaccact tgggcctata aaagctgcca caagacgcca aggccacaag

2161 ccacccagcc tatgcatccg ctcctcaatc ctctcctgtt ggcactgggc ctcatggcgc

2221 ttttgttgac cacggtcatt gctctcactt gccttggcgg ctttgcctcc ccaggccctg

2281 tgcctccctc tacagccctc agggagctca ttgaggagct ggtcaacatc acccagaacc

2341 agaaggtgag tgtcggctag ccagggtcct agctatgagg gctccagggt gggtgattcc

2401 caagatgagg tcatgagcag gctgggcctg gtcctaagat gcctgtaggt caggaaaaat

2461 ctccatggac caaggcccgg cccagccatg agggagagag gagctgggct ggggggctca

2521 gcactgtgga tggacctatg gaggtgtctg gcagactccc cagggactac ctgctctcct EPI-109 1249

2581 ggcctggcct tgtctgccac tgccagctcc tactcagcca ttcctgaaca gaggacagca 2641 gagaagggcc agcaccctct cagaaccatg tggcatttgc caactggatt ttgaccataa 2701 caatgcagcc attctcccaa gcaccatcat aggcccgαcc ttaaaggagg attcgttagt 2761 agagtccgct ccttgcccαa ctagtaacag ctcacatgtc tgagcactgc ttacaccagg 2821 cctggtgcac gtgctttatg tgtcatttca tcactgccag ccacctcaag aggcaggtac 2881 gatgaaccca ttctgctaag gttcagtgag gttaagtgac agaggctgga ttcaagccag 2941 gcctggccaa caccagagtg tccatgctcc taactgcagt gttccctcac catcagaagg 3001 cagggcattt aatacaccag atccccaccg cctcccatct gatttgtctt ggtcaacagt 3061 ggcccaggcc actcctactt cactcgtccc caccctggcc cttcccgcag gcccctgtcc 3121 tcctgccctg actatggcaa gccttgcatg cagcttgtcc cttactagtg gtgtcaattt 3181 ttttctctca gctccaagac cctaaacagt gggacctcac ccctatgcct gctgttcaaa 3241 gcagaaaacg aagctcagga atgctgaggg gctgccaggc ctgcctctgt gccacaccag 3301 ggatgcttgt ggggcctgtg ctggggcaga cctggcctgg gctgccaggg caggcccaca 3361 acccctgcca gcactctgct cactgtcact ttgctcccac aggctccgct ctgcaatggc 3421 agcatggtat ggagcatcaa cctgacagct ggcatggtaa ggacctttgg gtgcagggag 3481 gatggggcag aggctccagg ccttgggctt atcttctctg agcctccctt ccatggctgg 3541 ggttccaagc aagcttcaag tgctctcctc cctcccgcca taatctggcc ccttcccgcc 3601 caccacccag actcacctgc gccaggcatc tcagccccat cttcctgcag actcacaaaa 3661 ggcagctgcc caagcagggc ctgacccctc ggtgtcccct ccccacagta ctgtgcagcc 3721 ctggaatccc tgatcaacgt gtcaggctgc agtgccatcg agaagaccca gaggatgctg 3781 agcggattct gcccgcacaa ggtctcagct ggggtaaggc atcccccacc ctctcacacc 3841 caccctgcac cccctcctgc caaccctggg ctcgctgaag ggaagctggc tgaatatcca

3901 tggtgtgtgt ccacccaggg gtggggccat tgtggcagca gggacgtggc cttcgggatt 3961 tacaggatct gggctcaagg gctcctaact cctacctggg cctcaatttc cacatctgta 4021 cagtagaggt actaacagta cccacctcat ggggacttcc gtgaggactg aatgagacag 4081 tccctggaaa gcccctggtt tgtgcgagtc gtcccggcct ctggcgttct actcacgtgc 4141 tgacctcttt gtcctgcagc agttttccag cttgcatgtc cgagacacca aaatcgaggt 4201 ggcccagttt gtaaaggacc tgctcttaca tttaaagaaa ctttttcgcg agggacggtt 4261 caactgaaac ttcgaaagca tcattatttg cagagacagg acctgactat tgaagttgca 4321 gattcatttt tctttctgat gtcaaaaatg tcttgggtag gcgggaagga gggttaggga 4381 ggggtaaaat tccttagctt agacctcagc ctgtgctgcc cgtcttcagc ctagccgacc 4441 tcagccttcc ccttgcccag ggctcagcct ggtgggcctc ctctgtccag ggccctgagc 4501 tcggtggacc cagggatgac atgtccctac acccctcccc tgccctagag cacactgtag 4561 cattacagtg ggtgcccccc ttgccagaca tgtggtggga cagggaccca cttcacacac 4621 aggcaactga ggcagacagc agctcaggca cacttcttct tggtcttatt tattattgtg 4681 tgttatttaa atgagtgtgt ttgtcaccgt tggggattgg ggaagactgt ggctgctggc 4741 acttggagcc aagggttcag agactcaggg ccccagcact aaagcagtgg accccaggag 4801 tccctggtaa taagtactgt gtacagaatt ctgctacctc actggggtcc tggggcctcg 4861 gagcctcatc cgaggcaggg tcaggagagg ggcagaacag ccgctcctgt ctgccagcca

4921 gcagccagct ctcagccaac gagtaattta ttgtttttcc tcgtatttaa atattaaata 4981 tgttagcaaa gagttaatat atagaagggt accttgaaca ctgggggagg ggacattgaa 5041 caagttgttt cattgactat caaactgaag ccagaaataa agttggtgac agataggcct 5101 gattgtattt gtctttcatt ttggcctttg gggacactgg tctgtggtct gaagactctg 5161 aggagctctt cgggaggctg gtgggttgga ggaggggact gggatggatt acagcgaggg 5221 tagggtgcag tgacctgggc tgaatgcaag ctagctcccg agggtgggga catggcctga 5281 aggaagcccc accttctgtc tgctgcacca gcaaggacgg agaggcttgg gccagactgt 5341 cagggttcaa ggagggcatc aggagcagac ggagacccag gaagtctcac aatcacatct 5401 cctgaggact ggccagctgt gtctggcacc acccacacat ccatgtctcc ctcacaaccc 5461 aggaggccga tgagaactgt gaggctcaga aagcgtgggc ggtttgccta aggtcacgta 5521 gctacttcct cactggggtc ctggggcctc agagcctcat ctgaggtaaa ggagcaaagt 5581 tgggattggg gtccaaaatt cactttaact ccaaagccca cacacttaac caccctgcct 5641 atttctgtcc aaatgtcacc tgtcctgaat

(2) INFORMATION FOR SEQ ID NO: 84: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1282 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 84: aagccaccca gcctatgcat ccgctcctca atcctctcct gttggcactg ggcctcatgg

61 cgcttttgtt gaccacggtc attgctctca cttgccttgg cggctttgcc tccccaggcc

121 ctgtgcctcc ctctacagcc ctcagggagc tcattgagga gctggtcaac atcacccaga

181 accagaaggc tccgctctgc aatggcagca tggtatggag catcaacctg acagctggca

241 tgtactgtgc agccctggaa tccctgatca acgtgtcagg ctgcagtgcc atcgagaaga

301 cccagaggat gctgagcgga ttctgcccgc acaaggtctc agctgggcag ttttccagct

361 tgcatgtccg agacaccaaa atcgaggtgg cccagtttgt aaaggacctg ctcttacatt

421 taaagaaact ttttcgcgag ggacggttca actgaaactt cgaaagcatc attatttgca

481 gagacaggac ctgactattg aagttgcaga ttcatttttc tttctgatgt caaaaatgtc

541 ttgggtaggc gggaaggagg gttagggagg ggtaaaattc cttagcttag acctcagcct

601 gtgctgcccg tcttcagcct agccgacctc agccttcccc ttgcccaggg ctcagcctgg

661 tgggcctcct ctgtccaggg ccctgagctc ggtggaccca gggatgacat gtccctacac

721 ccctcccctg ccctagagca cactgtagca ttacagtggg tgcccccctt gccagacatg

781 tggtgggaca gggacccact tcacacacag gcaactgagg cagacagcag ctcaggcaca

841 cttcttcttg gtcttattta ttattgtgtg ttatttaaat gagtgtgttt gtcaccgttg EPI-109 1250

901 gggattgggg aagactgtgg ctgctggcac ttggagccaa gggttcaαag actcagggcc

961 ccagcactaa agcagtggac cccaggagtc cctggtaata agtactgtgt acagaattct

1021 gctacctcac tggggtcctg gggcctcgga gcctcatccg aggcagggtc aggagagggg

1081 cagaacagcc gctcctgtct gccagccagc agccagctct cagccaaaga gtaatttatt

1141 gtttttcctc gtatttaaat attaaatatg ttagcaaaga gttaatatat agaagggtac

1201 cttgaacact gggggagggg acattgaaca agttgtttca ttgactatca aactgaagcc

1261 agaaataaag ttggtgacag at

(2) INFORMATION FOR SEQ ID NO: 85: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 6952 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 85: 1 ggatccccgc tgacaatcta gaaacaagca acagaccctc tgatgtagcc atctgtgccg

61 cgcctctccg caccgcccgc cacgccttgg tccctggaga ccaccctcca gggcaggggc

121 tgccgctcgg ccgggcccgc ggggtccctc ggcctgacat ggccggtgct ggagcggcac

181 gtgcgcgcct cggcccctcg gccgctcccg cccctcgccg gtgcgcaccg gcgctcgggg

241 agccgctggc ccgggtgtcc agccggccct tgccctgcct ggcgctcgga ccgccacctt

301 tgccgccccc tcgccagcct ccgcagcttc cagactggcc ggtctgcgcg cccacccctg

361 cctcccggac cggccaccgc cggaggccgc ggaggagggc ccggccgcgc agatcccgct

421 tatcgggccc catctcccgt tacataaggc caccccccta tctccgcggg ccatcgccgc

481 cgcaaccgcc gcgccagcgc cttctcccac gcgcgggggc gcccctgccc accgctcccg

541 gcagggcttt tggtggccat gggggataag gggcgttgac tcacccgggc ggggctccgg

601 gagttgcaca gaccaaggta gttccccgct ccttccccca tcacggagac cctgtgggag

661 atgccgtggg ccctctacta cagattagga aacaggcccg tagaggggtc gcgcggccaa

721 gtagcggcac tccaggcact gggggccctc gagggaaggg gcagacttct gggagtcaga

781 gccagcagct gggctgggaa gcttcgagtg tggacagaga gggtgggaat gacgttccct

841 gtgggaagag agggtgggca agcctgggat gcctctgagc gggaatccag catgccttgt

901 gaggagggtc acaagcacac ccttgtgagg aggttgagcc ccatcgagga caggacggag

961 ggagcctgag caggcagaga gggggcctgg ggaggcgctg gttcggggag gaagtgggta

1021 ggggagaaat cttgacatca acacccaaca ggcaaatgcc gtggcctctg ctgtgggggt

1081 ttctggagga cttctaggaa aacgagggaa gagcaggaaa aggcgacatg gctgtagggc

1141 caagcccagg agccgccctc cacagcactc attctgcaga agggaaattt gaggccccca

1201 gacggcaggg gttgatcctg cagagactgg tgagcaaagg ggatcacccc aagccccagt

1261 ggcactagga acacttacaa tctctgacct ggactaaggc tgccagcctg gcccagttaa

1321 gagtttccca gaaggatggc ccatacactt taaattaaag gggccagaca cgtgcacact

1381 acttccagcc actctggaag ctgaggtggg gggatcgctt gagtctggga gttggaggcc

1441 agcctaggca ggcaacatag tgagacccca tctccaaaaa aacaaaacaa aacaaaacaa

1501 aaaaacacca aaaaagctcc cagaaagacc tctgaatctt tctggatctc tcagtggaga

1561 cctggaaatc tgaactttga caatccctct cacagtgggg ccaaggagga attaggcaag

1621 ccaaaagaag tgaactttac tcttctattg cctgtttgaa ttttgtatcc aagcaagtgt

1681 tacttaagta atttaagaga ctggttcatc gaaaaaataa aactccccaa attcccatag

1741 ctggtagact gtggtcacag ccacagtgca ctaagactat ctgctcagca cttctggtga

1801 cccaaaaggg tctgaggaca ggagctcaga gttgggtcag ctgtccaggt actcagggtt

1861 gtcacaggca aaactgctgg aactcagggc agcattgcaa atgccacgcc gctctcaggg

1921 ccccttgcct gccgctggaa ttaaacccac ccagatcttg gaaactctgc cctggaccct

1981 tctcaataag tccatgagaa atcaaactct ttcctttatg cgacactgga ttttccacaa

2041 agtaaaatca agatgagtaa agatgtggtt tctagatagt gcctgaaaaa gcagagacca

2101 tggtgtcagg cgtcaccact tgggcctata aaagctgcca caagacgcca aggccacaag

2161 ccacccagcc tatgcatccg ctcctcaatc ctctcctgtt ggcactgggc ctcatggcgc

2221 ttttgttgac cacggtcatt gctctcactt gccttggcgg ctttgcctcc ccaggccctg

2281 tgcctccctc tacagccctc agggagctca ttgaggagct ggtcaacatc acccagaacc

2341 agaaggtgag tgtcggctag ccagggtcct agctatgagg gctccagggt gggtgattcc

2401 caagatgagg tcatgagcag gctgggcctg gtcctaagat gcctgtaggt caggaaaaat

2461 ctccatggac caaggcccgg cccagccatg agggagagag gagctgggct ggggggctca

2521 gcactgtgga tggacctatg gaggtgtctg gcagactccc cagggactac ctgctctcct

2581 ggcctggcct tgtctgccac tgccagctcc tactcagcca ttcctgaaca gaggacagca

2641 gagaagggcc agcaccctcc cagaaccatg tggcatttgc caactggatt ttgaccataa

2701 caatgcagcc attctcccca gcaccatcat aggcccgccc ttacaggagg attcgttagt

2761 agagtccgct ccttgcccca ctagtaacag ctcacatgtc tgagcactgc ttacaccagg

2821 cctggtgcac gtgctttatg tgtcatttca tcactgccag ccacctcaag aggcaggtac

2881 gatgaaccca ttctgctaag gttcagtgag gttaagtgac agaggctgga ttcaagccag

2941 gcctggccaa caccagagtg tccatgctcc taactgcagt gttccctcac catcagaagg

3001 cagggcattt aatacaccag atccccaccg cctcccatct gatttgtctt ggtcaacagt

3061 ggcccaggcc actcctactt cactcgtccc caccctggcc cttcccgcag gcccctgtcc

3121 tcctgccctg actatggcaa gccttgcatg cagcttgtcc cttactagtg gtgtcaattt

3181 ttttctctca gctccaagac cctaaacagt gggacctcac ccctatgcct gctgttcaaa

3241 gcagaaaacg aagctcagga atgctgaggg gctgccaggc ctgcctctgt gccacaccag

3301 ggatgcttgt ggggcctgtg ctggggcaga cctggcctgg gctgccaggg caggcccaca

3361 acccctgcca gcactctgct cactgtcact ttgctcccac aggctccgct ctgcaatggc

3421 agcatggtat ggagcatcaa cctgacagct ggcatggtaa ggacctttgg gtgcagggag

3481 gatggggcag aggctccagg ccttgggctt atcttctctg agcctccctt ccatggctgg

3541 ggttccaagc aagcttcaag tgctctcctc cctcccgcca taatctggcc ccttcccgcc EPI-109 1251

3601 caccacccag actcacctgc gccaggcatc tcagccccat cttcctgcag actcacaaaa 3661 ggcagctgcc caagcagggc ctgacccctc ggtgtcccct ccccacagta ctgtgcagcc 3721 ctggaatccc tgatcaacgt gtcaggctgc agtgccatcg agaagaccca gaggatgctg 3781 agcggattct gcccgcacaa ggtctcagct ggggtaaggc atcccccacc ctctcacacc 3841 caccctgcac cccctcctgc caaccctggg ctcgctgaag ggaagctggc tgaatatcca 3901 tggtgtgtgt ccacccaggg gtggggccat tgtggcagca gggacgtggc cttcgggatt 3961 tacaggatct gggctcaagg gctcctaact cctacctggg cctcaatttc cacatctgta 4021 cagtagaggt actaacagta cccacctcat ggggacttcc gtgaggactg aatgagacag 4081 tccctggaaa gcccctggtt tgtgcgagtc gtcccggcct ctggcgttct actcacgtgc 4141 tgacctcttt gtcctgcagc agttttccag cttgcatgtc cgagacacca aaatcgaggt 4201 ggcccagttt gtaaaggacc tgctcttaca tttaaagaaa ctttttcgcg agggacggtt 4261 caactgaaac ttcgaaagca tcattatttg cagagacagg acctgactat tgaagttgca 4321 gattcatttt tctttctgat gtcaaaaatg tcttgggtag gcgggaagga gggttaggga 4381 ggggtaaaat tccttagctt agacctcagc ctgtgctgcc cgtcttcagc ctagccgacc 4441 tcagccttcc ccttgcccag ggctcagcct ggtgggcctc ctctgtccag ggccctgagc 4501 tcggtggacc cagggatgac atgtccctac acccctcccc tgccctagag cacactgtag 4561 cattacagtg ggtgcccccc ttgccagaca tgtggtggga cagggaccca cttcacacac 4621 aggcaactga ggcagacagc agctcaggca cacttcttct tggtcttatt tattattgtg 4681 tgttatttaa atgagtgtgt ttgtcaccgt tggggattgg ggaagactgt ggctgctggc 4741 acttggagcc aagggttcag agactcaggg ccccagcact aaagcagtgg accccaggag 4801 tccctggtaa taagtactgt gtacagaatt ctgctacctc actggggtcc tggggcctcg 4861 gagcctcatc cgaggcaggg tcaggagagg ggcagaacag ccgctcctgt ctgccagcca 4921 gcagccagct ctcagccaac gagtaattta ttgtttttcc tcgtatttaa atattaaata 4981 tgttagcaaa gagttaatat atagaagggt accttgaaca ctgggggagg ggacattgaa 5041 caagttgttt cattgactat caaactgaag ccagaaataa agttggtgac agataggcct 5101 gattgtattt gtctttcatt ttggcctttg gggacactgg tctgtggtct gaagactctg 5161 aggagctctt cgggaggctg gtgggttgga ggaggggact gggatggatt acagcgaggg 5221 tagggtgcag tgacctgggc tgaatgcaag ctagctcccg agggtgggga catggcctga 5281 aggaagcccc accttctgtc tgctgcacca gcaaggacgg agaggcttgg gccagactgt 5341 cagggttcaa ggagggcatc aggagcagac ggagacccag gaagtctcac aatcacatct 5401 cctgaggact ggccagctgt gtctggcacc acccacacat ccatgtctcc ctcacaaccc 5461 aggaggccga tgagaactgt gaggctcaga aagcgtgggc ggtttgccta aggtcacgta 5521 gctacttcct cactggggtc ctggggcctc agagcctcat ctgaggtaaa ggagcaaagt 5581 tgggattggg gtccaaaatt cactttaact ccaaagccca cacacttaac caccctgcct 5641 atttctgtcc aaatgtcacc tgtcctgaat 1 aagccaccca gcctatgcat ccgctcctca atcctctcct gttggcactg ggcctcatgg

61 cgcttttgtt gaccacggtc attgctctca cttgccttgg cggctttgcc tccccaggcc

121 ctgtgcctcc ctctacagcc ctcagggagc tcattgagga gctggtcaac -atcacccaga

181 accagaaggc tccgctctgc aatggcagca tggtatggag catcaacctg acagctggca

241 tgtactgtgc agccctggaa tccctgatca acgtgtcagg ctgcagtgcc atcgagaaga

301 cccagaggat gctgagcgga ttctgcccgc acaaggtctc agctgggcag ttttccagct

361 tgcatgtccg agacaccaaa atcgaggtgg cccagtttgt aaaggacctg ctcttacatt

421 taaagaaact ttttcgcgag ggacggttca actgaaactt cgaaagcatc attatttgca

481 gagacaggac ctgactattg aagttgcaga ttcatttttc tttctgatgt caaaaatgtc

541 ttgggtaggc gggaaggagg gttagggagg ggtaaaattc cttagcttag acctcagcct

601 gtgctgcccg tcttcagcct agccgacctc agccttcccc ttgcccaggg ctcagcctgg

661 tgggcctcct ctgtccaggg ccctgagctc ggtggaccca gggatgacat gtccctacac

721 ccctcccctg ccctagagca cactgtagca ttacagtggg tgcccccctt gccagacatg

781 tggtgggaca gggacccact tcacacacag gcaactgagg cagacagcag ctcaggcaca

841 cttcttcttg gtcttattta ttattgtgtg ttatttaaat gagtgtgttt gtcaccgttg

901 gggattgggg aagactgtgg ctgctggcac ttggagccaa gggttcagag actcagggcc

961 ccagcactaa agcagtggac cccaggagtc cctggtaata agtactgtgt acagaattct

1021 gctacctcac tggggtcctg gggcctcgga gcctcatccg aggcagggtc aggagagggg

1081 cagaacagcc gctcctgtct gccagccagc agccagctct cagccaacga gtaatttatt

1141 gtttttcctc gtatttaaat attaaatatg ttagcaaaga gttaatatat agaagggtac

1201 cttgaacact gggggagggg acattgaaca agttgtttca ttgactatca aactgaagcc

1261 agaaataaag ttggtgacag at

(2) INFORMATION FOR SEQ ID NO: 86: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1270 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 86: ttcggcatcc gctcctcaat cctctcctgt tggcactggg cctcatggcg cttttgttga

61 ccacggtcat tgctctcact tgccttggcg gctttgcctc cccaggccct gtgcctccct

121 ctacagccct cagggagctc attgaggagc tggtcaacat cacccagaac cagaaggctc

181 cgctctgcaa tggcagcatg gtatggagca tcaacctgac agctggcatg tactgtgcag

241 ccctggaatc cctgatcaac gtgtcaggct gcagtgccat cgagaagacc cagaggatgc

301 tgagcggatt ctgcccgcac aaggtctcag ctgggcagtt ttccagcttg catgtccgag

361 acaccaaaat cgaggtggcc cagtttgtaa aggacctgct cttacattta aagaaacttt

421 ttcgcgaggg acggttcaac tgaaacttcg aaagcatcat tatttgcaga gacaggacct

481 gactattgaa gttgcagatt catttttctt tctgatgtca aaaatgtctt gggtaggcgg

541 gaaggagggt tagggagggg taaaattcct tagcttagac ctcagcctgt gctgcccgtc EPI-109 1252

601 ttcagcctag ccgacctcag ccttcccctt gcccagggct cagcctggtg ggcctcctct

661 gtccagggcc ctgagctcag tggacccagg gatgacatgt ccctacaccc ctcccctgcc

721 ctagagcaca ctgtagcatt acagtgggtg ccccccttgc cagacatgtg gtgggacagg

781 gacccacttc acacacaggc aactgaggca gacagcagct caggcacact tcttcttggt

841 cttatttatt attgtgtgtt atttaaatga gtgtgtttgt caccgttggg gattggggaa

901 gactgtggct gctggcactt ggagccaagg gttcagagac tcagggcccc agcactaaag

961 cagtggaccc caggagtccc tggtaataag tactgtgtac agaattctgc tacctcactg

1021 gggtcctggg gcctcggagc ctcatccgag gcagggtcag gagaggggca gaacagccgc

1081 tcctgtctgc cagccagcag ccagctctca gccaacgagt aatttattgt ttttcctcgt

1141 atttaaatat taaatatgtt agcaaagagt taatatatag aagggtacct tgaacactgg

1201 gggaggggac attgaacaag ttgtttcatt gactatcaaa ctgaagccag aaataaagtt

1261 ggtgacagat

(2) INFORMATION FOR SEQ ID NO: 87: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3999 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 87:

1 tcagcccggc cgggctccga ggcgagaggc tgcatggagt ggccggcgcg gctctgcggg

61 ctgtgggcgc tgctgctctg cgccggcggc gggggcgggg gcgggggcgc cgcgcctacg

121 gaaactcagc cacctgtgac aaatttgagt gtctctgttg aaaacctctg cacagtaata

181 tggacatgga atccacccga gggagccagc tcaaattgta gtctatggta ttttagtcat

241 tttggcgaca aacaagataa gaaaatagct ccggaaactc gtcgttcaat agaagtaccc

301 ctgaatgaga ggatttgtct gcaagtgggg tcccagtgta gcaccaatga gagtgagaag

361 cctagcattt tggttgaaaa atgcatctca cccccagaag gtgatcctga gtctgctgtg

421 actgagcttc aatgcatttg gcacaacctg agctacatga agtgttcttg gctccctgga

481 aggaatacca gtcccgacac taactatact ctctactatt ggcacagaag cctggaaaaa

541 attcatcaat gtgaaaacat ctttagagaa ggccaatact ttggttgttc ctttgatctg

601 accaaagtga aggattccag ttttgaacaa cacagtgtcc aaataatggt caaggataat

661 gcaggaaaaa ttaaaccatc cttcaatata gtgcctttaa cttcccgtgt gaaacctgat

721 cctccacata ttaaaaacct ctccttccac aatgatgacc tatatgtgca atgggagaat

781 ccacagaatt ttattagcag atgcctattt tatgaagtag aagtcaataa cagccaaact

841 gagacacata atgttttcta cgtccaagag gctaaatgtg agaatccaga atttgagaga

901 aatgtggaga atacatcttg tttcatggtc cctggtgttc ttcctgatac tttgaacaca

961 gtcagaataa gagtcaaaac aaataagtta tgctatgagg atgacaaact ctggagtaat

1021 tggagccaag aaatgagtat aggtaagaag cgcaattcca cactctacat aaccatgtta

1081 ctcattgttc cagtcatcgt cgcaggtgca atcatagtac tcctgcttta cctaaaaagg

1141 ctcaagatta ttatattccc tccaattcct gatcctggca agatttttaa agaaatgttt

1201 ggagaccaga atgatgatac tctgcactgg aagaagtacg acatctatga gaagcaaacc

1261 aaggaggaaa ccgactctgt agtgctgata gaaaacctga agaaagcctc tcagtgatgg

1321 agataattta tttttacctt cactgtgacc ttgagaagat tcttcccatt ctccatttgt

1381 tatctgggaa cttattaaat ggaaactgaa actactgcac catttaaaaa caggcagctc

1441 ataagagcca caggtcttta tgttgagtcg cgcaccgaaa aactaaaaat aatgggcgct

1501 ttggagaaga gtgtggagtc attctcattg aattataaaa gccagcaggc ttcaaactag

1561 gggacaaagc aaaaagtgat gatagtggtg gagttaatct tatcaagagt tgtgacaact

1621 tcctgaggga tctatacttg ctttgtgttc tttgtgtcaa catgaacaaa ttttatttgt

1681 aggggaactc atttggggtg caaatgctaa tgtcaaactt gagtcacaaa gaacatgtag

1741 aaaacaaaat ggataaaatc tgatatgtat tgtttgggat cctattgaac catgtttgtg

1801 gctattaaaa ctcttttaac agtctgggct gggtccggtg gctcacgcct gtaatcccag

1861 caatttggga gtccgaggcg ggcggatcac tcgaggtcag gagttccaga ccagcctgac

1921 caaaatggtg aaacctcctc tctactaaaa ctacaaaaat taactgggtg tggtggcgcg

1981 tgcctgtaat cccagctact cgggaagctg aggcaggtga attgtttgaa cctgggaggt

2041 ggaggttgca gtgagcagag atcacaccac tgcactctag cctgggtgac agagcaagac

2101 tctgtctaaa aaacaaaaca aaacaaaaca aaacaaaaaa acctcttaat attctggagt

2161 catcattccc ttcgacagca ttttcctctg ctttgaaagc cccagaaatc agtgttggcc

2221 atgatgacaa ctacagaaaa accagaggca gcttctttgc caagaccttt caaagccatt

2281 ttaggctgtt aggggcagtg gaggtagaat gactccttgg gtattagagt ttcaaccatg

2341 aagtctctaa caatgtattt tcttcacctc tgctactcaa gtagcattta ctgtgtcttt

2401 ggtttgtgct aggcccccgg gtgtgaagca cagacccctt ccaggggttt acagtctatt

2461 tgagactcct cagttcttgc cacttttttt tttaatctcc accagtcatt tttcagacct

2521 tttaactcct caattccaac actgatttcc ccttttgcat tctccctcct tcccttcctt

2581 gtagcctttt gactttcatt ggaaattagg atgtaaatct gctcaggaga cctggaggag

2641 cagaggataa ttagcatctc aggttaagtg tgagtaatct gagaaacaat gactaattct

2701 tgcatatttt gtaacttcca tgtgagggtt ttcagcattg atatttgtgc attttctaaa

2761 cagagatgag gtggtatctt cacgtagaac attggtattc gcttgagaaa aaaagaatag

2821 ttgaacctat ttctctttct ttacaagatg ggtccaggat tcctcttttc tctgccataa

2881 atgattaatt aaatagcttt tgtgtcttac attggtagcc agccagccaa ggctctgttt

2941 atgcttttgg ggggcatata ttgggttcca ttctcaccta tccacacaac atatccgtat

3001 atatcccctc tactcttact tcccccaaat ttaaagaagt atgggaaatg agaggcattt

3061 cccccacccc atttctctcc tcacacacag actcatatta ctggtaggaa cttgagaact

3121 ttatttccaa gttgttcaaa catttaccaa tcatattaat acaatgatgc tatttgcaat

3181 tcctgctcct aggggagggg agataagaaa ccctcactct ctacaggttt gggtacaagt

3241 ggcaacctgc ttccatggcc gtgtagaagc atggtgccct ggcttctctg aggaagctgg EPI-109 1253

3301 ggttcatgac aatggcagat gtaaagttat tcttgaagtc acattgaggc tgggagacag

3361 ccgtagtaga tgttctactt tgttctgctg ttctctagaa agaatatttg gttttcctgt

3421 ataggaatga gattaattcc tttccaggta ttttataatt ctgggaagca aaacccatgc

3481 ctccccctag ccatttttac tgttatccta tttagatggc catgaagagg atgctgtgaa

3541 attcccaaca aacattgatg ctgacagtca tgcagtctgg gagtggggaa gtgatctttt

3601 gttcccatcc tcttctttta gcagtaaaat agctgaggga aaagggaggg aaaaggaagt

3661 tatgggaata cctgtggtgg ttgtgatccc taggtcttgg gagctcttgg aggtgtctgt

3721 atcagtggat ttcccatccc ctgtgggaaa ttagtaggct catttactgt tttaggtcta

3781 gcctatgtgg attttttcct aacataccta agcaaaccca gtgtcaggat ggtaattctt

3841 attctttcgt tcagttaagt ttttcccttc atctgggcac tgaagggata tgtgaaacaa

3901 tgttaacatt tttggtagtc ttcaaccagg gattgtttct gtttaacttc ttataggaaa

3961 gcttgagtaa aataaatatt gtctttttgt atgtcaccc

(2) INFORMATION FOR SEQ ID NO: 88: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4039 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 88: 1 tgccaaggct ccagcccggc cgggctccga ggcgagaggc tgcatggagt ggccggcgcg

61 gctctgcggg ctgtgggcgc tgctgctctg cgccggcggc gggggcgggg gcgggggcgc

121 cgcgcctacg gaaactcagc cacctgtgac aaatttgagt gtctctgttg aaaacctctg

181 cacagtaata tggacatgga atccacccga gggagccagc tcaaattgta gtctatggta

241 ttttagtcat tttggcgaca aacaagataa gaaaatagct ccggaaactc gtcgttcaat

301 agaagtaccc ctgaatgaga ggatttgtct gcaagtgggg tcccagtgta gcaccaatga

361 gagtgagaag cctagcattt tggttgaaaa atgcatctca cccccagaag gtgatcctga

421 gtctgctgtg actgagcttc aatgcatttg gcacaacctg agctacatga agtgttcttg

481 gctccctgga aggaatacca gtcccgacac taactatact ctctactatt ggcacagaag

541 cctggaaaaa attcatcaat gtgaaaacat ctttagagaa ggccaatact ttggttgttc

601 ctttgatctg accaaagtga aggattccag ttttgaacaa cacagtgtcc aaataatggt

661 caaggataat gcaggaaaaa ttaaaccatc cttcaatata gtgcctttaa cttcccgtgt

721 gaaacctgat cctccacata ttaaaaacct ctccttccac aatgatgacc tatatgtgca

781 atgggagaat ccacagaatt ttattagcag atgcctattt tatgaagtag aagtcaataa

841 cagccaaact gagacacata atgttttcta cgtccaagag gctaaatgtg agaatccaga

901 atttgagaga aatgtggaga atacatcttg tttcatggtc cctggtgttc ttcctgatac

961 tttgaacaca gtcagaataa gagtcaaaac aaataagtta tgctatgagg atgacaaact

1021 ctggagtaat tggagccaag aaatgagtat aggtaagaag cgcaattcca cactctacat

1081 aaccatgtta ctcattgttc cagtcatcgt cgcaggtgca atcatagtac tcctgcttta

1141 cctaaaaagg ctcaagatta ttatattccc tccaattcct gatcctggca agatttttaa

1201 agaaatgttt ggagaccaga atgatgatac tctgcactgg aagaagtacg acatctatga

1261 gaagcaaacc aaggaggaaa ccgactctgt agtgctgata gaaaacctga agaaagcctc

1321 tcagtgatgg agataattta tttttacctt cactgtgacc ttgagaagat tcttcccatt

1381 ctccatttgt tatctgggaa cttattaaat ggaaactgaa actactgcac catttaaaaa

1441 caggcagctc ataagagcca caggtcttta tgttgagtcg cgcaccgaaa aactaaaaat

1501 aatgggcgct ttggagaaga gtgtggagtc attctcattg aattataaaa gccagcaggc

1561 ttcaaactag gggacaaagc aaaaagtgat gatagtggtg gagttaatct tatcaagagt

1621 tgtgacaact tcctgaggga tctatacttg ctttgtgttc tttgtgtcaa catgaacaaa

1681 ttttatttgt aggggaactc atttggggtg caaatgctaa tgtcaaactt gagtcacaaa

1741 gaacatgtag aaaacaaaat ggataaaatc tgatatgtat tgtttgggat cctattgaac

1801 catgtttgtg gctattaaaa ctcttttaac agtctgggct gggtccggtg gctcacgcct

1861 gtaatcccag caatttggga gtccgaggcg ggcggatcac tcgaggtcag gagttccaga

1921 ccagcctgac caaaatggtg aaacctcctc tctactaaaa ctacaaaaat taactgggtg

1981 tggtggcgcg tgcctgtaat cccagctact cgggaagctg aggcaggtga attgtttgaa

2041 cctgggaggt ggaggttgca gtgagcagag atcacaccac tgcactctag cctgggtgac

2101 agagcaagac tctgtctaaa aaacaaaaca aaacaaaaca aaacaaaaaa acctcttaat

2161 attctggagt catcattccc ttcgacagca ttttcctctg ctttgaaagc cccagaaatc

2221 agtgttggcc atgatgacaa ctacagaaaa accagaggca gcttctttgc caagaccttt

2281 caaagccatt ttaggctgtt aggggcagtg gaggtagaat gactccttgg gtattagagt

2341 ttcaaccatg aagtctctaa caatgtattt tcttcacctc tgctactcaa gtagcattta

2401 ctgtgtcttt ggtttgtgct aggcccccgg gtgtgaagca cagacccctt ccaggggttt

2461 acagtctatt tgagactcct cagttcttgc cacttttttt tttaatctcc accagtcatt

2521 tttcagacct tttaactcct caattccaac actgatttcc ccttttgcat tctccctcct

2581 tcccttcctt gtagcctttt gactttcatt ggaaattagg atgtaaatct gctcaggaga

2641 cctggaggag cagaggataa ttagcatctc aggttaagtg tgagtaatct gagaaacaat

2701 gactaattct tgcatatttt gtaacttcca tgtgagggtt ttcagcattg atatttgtgc

2761 attttctaaa cagagatgag gtggtatctt cacgtagaac attggtattc gcttgagaaa

2821 aaaagaatag ttgaacctat ttctctttct ttacaagatg ggtccaggat tcctcttttc

2881 tctgccataa atgattaatt aaatagcttt tgtgtcttac attggtagcc agccagccaa

2941 ggctctgttt atgcttttgg ggggcatata ttgggttcca ttctcaccta tccacacaac

3001 atatccgtat atatcccctc tactcttact tcccccaaat ttaaagaagt atgggaaatg

3061 agaggcattt cccccacccc atttctctcc tcacacacag actcatatta ctggtaggaa

3121 cttgagaact ttatttccaa gttgttcaaa catttaccaa tcatattaat acaatgatgc

3181 tatttgcaat tcctgctcct aggggagggg agataagaaa ccctcactct ctacaggttt

3241 gggtacaagt ggcaacctgc ttccatggcc gtgtagaagc atggtgccct ggcttctctg EPI-109 1254

3301 aggaagctgg ggttcatgac aatggcagat gtaaagttat tcttgaagtc agattgaggc 3361 tgggagacag ccgtagtaga tgttctactt tgttctgctg ttctctagaa agaatatttg 3421 gttttcctgt ataggaatga gattaattcc tttccaggta ttttataatt ctgggaagca 3481 aaacccatgc ctccccctag ccatttttac tgttatccta tttagatggc catgaagagg 3541 atgctgtgaa attcccaaca aacattgatg ctgacagtca tgcagtctgg gagtggggaa 3601 gtgatctttt gttcccatcc tcttctttta gcagtaaaat agctgaggga aaagggaggg 3661 aaaaggaagt tatgggaata cctgtggtgg ttgtgatccc taggtcttgg gagctcttgg 3721 aggtgtctgt atcagtggat ttcccatccc ctgtgggaaa ttagtaggct catttactgt 3781 tttaggtcta gcctatgtgg attttttcct aacataccta agcaaaccca gtgtcaggat 3841 ggtaattctt attctttcgt tcagttaagt ttttcccttc atctgggcac tgaagggata 3901 tgtgaaacaa tgttaacatt tttggtagtc ttcaaccagg gattgtttct gtttaacttc 3961 ttataggaaa gcttgagtaa aataaatatt gtctttttgt atgtcaagcg ggccgccacc 4021 gcggtggaaa ctccagctt

(2) INFORMATION FOR SEQ ID NO: 89: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 5670 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 89: ggatccccgc tgacaatcta gaaacaagca acagaccctc tgatgtagcc atctgtgccg

61 cgcctctccg caccgcccgc cacgccttgg tccctggaga ccaccctcca gggcaggggc

121 tgccgctcgg ccgggcccgc ggggtccctc ggcctgacat ggccggtgct ggagcggcac

181 gtgcgcgcct cggcccctcg gccgctcccg cccctcgccg gtgcgcaccg gcgctcgggg

241 agccgctggc ccgggtgtcc agccggccct tgccctgcct ggcgctcgga ccgccacctt

301 tgccgccccc tcgccagcct ccgcagcttc cagactggcc ggtctgcgcg cccacccctg

361 cctcccggac cggccaccgc cggaggccgc ggaggagggc ccggccgcgc agatcccgct

421 tatcgggccc catctcccgt tacataaggc caccccccta tctccgcggg ccatcgccgc

481 cgcaaccgcc gcgccagcgc cttctcccac gcgcgggggc gcccctgccc accgctcccg

541 gcagggcttt tggtggccat gggggataag gggcgttgac tcacccgggc ggggctccgg

601 gagttgcaca gaccaaggta gttccccgct ccttccccca tcacggagac cctgtgggag

661 atgccgtggg ccctctacta cagattagga aacaggcccg tagaggggtc gcgcggccaa

721 gtagcggcac tccaggcact gggggccctc gagggaaggg gcagacttct gggagtcaga

781 gccagcagct gggctgggaa gcttcgagtg tggacagaga gggtgggaat gacgttccct

841 gtgggaagag agggtgggca agcctgggat gcctctgagc gggaatccag catgccttgt

901 gaggagggtc acaagcacac ccttgtgagg aggttgagcc ccatcgagga caggacggag

961 ggagcctgag caggcagaga gggggcctgg ggaggcgctg gttcggggag gaagtgggta

1021 ggggagaaat cttgacatca acacccaaca ggcaaatgcc gtggcctctg ctgtgggggt

1081 ttctggagga cttctaggaa aacgagggaa gagcaggaaa aggcgacatg gctgtagggc

1141 caagcccagg agccgccctc cacagcactc attctgcaga agggaaattt gaggccccca

1201 gacggcaggg gttgatcctg cagagactgg tgagcaaagg ggatcacccc aagccccagt

1261 ggcactagga acacttacaa tctctgacct ggactaaggc tgccagcctg gcccagttaa 1321 gagtttccca gaaggatggc ccatacactt taaattaaag gggccagaca cgtgcacact 1381 acttccagcc actctggaag ctgaggtggg gggatcgctt gagtctggga gttggaggcc

1441 agcctaggca ggcaacatag tgagacccca tctccaaaaa aacaaaacaa aacaaaacaa 1501 aaaaacacca aaaaagctcc cagaaagacc tctgaatctt tctggatctc tcagtggaga 1561 cctggaaatc tgaactttga caatccctct cacagtgggg ccaaggagga attaggcaag 1621 ccaaaagaag tgaactttac tcttctattg cctgtttgaa ttttgtatcc aagcaagtgt 1681 tacttaagta atttaagaga ctggttcatc gaaaaaataa aactccccaa attcccatag 1741 ctggtagact gtggtcacag ccacagtgca ctaagactat ctgctcagca cttctggtga 1801 cccaaaaggg tctgaggaca ggagctcaga gttgggtcag ctgtccaggt actcagggtt 1861 gtcacaggca aaactgctgg aactcagggc agcattgcaa atgccacgcc gctctcaggg 1921 ccccttgcct gccgctggaa ttaaacccac ccagatcttg gaaactctgc cctggaccct 1981 tctcaataag tccatgagaa atcaaactct ttcctttatg cgacactgga ttttccacaa 2041 agtaaaatca agatgagtaa agatgtggtt tctagatagt gcctgaaaaa gcagagacca 2101 tggtgtcagg cgtcaccact tgggcctata aaagctgcca caagacgcca aggccacaag 2161 ccacccagcc tatgcatccg ctcctcaatc ctctcctgtt ggcactgggc ctcatggcgc 2221 ttttgttgac cacggtcatt gctctcactt gccttggcgg ctttgcctcc ccaggccctg 2281 tgcctccctc tacagccctc agggagctca ttgaggagct ggtcaacatc acccagaacc 2341 agaaggtgag tgtcggctag ccagggtcct agctatgagg gctccagggt gggtgattcc 2401 caagatgagg tcatgagcag gctgggcctg gtcctaagat gcctgtaggt caggaaaaat 2461 ctccatggac caaggcccgg cccagccatg agggagagag gagctgggct ggggggctca 2521 gcactgtgga tggacctatg gaggtgtctg gcagactccc cagggactac ctgctctcct 2581 ggcctggcct tgtctgccac tgccagctcc tactcagcca ttcctgaaca gaggacagca 2641 gagaagggcc agcaccctcc cagaaccatg tggcatttgc caactggatt ttgaccataa 2701 caatgcagcc attctcccca gcaccatcat aggcccgccc ttacaggagg attcgttagt 2761 agagtccgct ccttgcccca ctagtaacag ctcacatgtc tgagcactgc ttacaccagg 2821 cctggtgcac gtgctttatg tgtcatttca tcactgccag ccacctcaag aggcaggtac 2881 gatgaaccca ttctgctaag gttcagtgag gttaagtgac agaggctgga ttcaagccag 2941 gcctggccaa caccagagtg tccatgctcc taactgcagt gttccctcac catcagaagg 3001 cagggcattt aatacaccag atccccaccg cctcccatct gatttgtctt ggtcaacagt 3061 ggcccaggcc actcctactt cactcgtccc caccctggcc cttcccgcag gcccctgtcc 3121 tcctgccctg actatggcaa gccttgcatg cagcttgtcc cttactagtg gtgtcaattt 3181 ttttctctca gctccaagac cctaaacagt gggacctcac ccctatgcct gctgttcaaa EPI-109 1255

3241 gcagaaaacg aagctcagga atgctgaggg gctgccaggc ctgcctctgt gccacaccag 3301 ggatgcttgt ggggcctgtg ctggggcaga cctggcctgg gctgccaggg caggcccaca 3361 acccctgcca gcactctgct cactgtcact ttgctcccac aggctccgct ctgcaatggc 3421 agcatggtat ggagcatcaa cctgacagct ggcatggtaa ggacctttgg gtgcagggag 3481 gatggggcag aggctccagg ccttgggctt atcttctctg agcctccctt ccatggctgg 3541 ggttccaagc aagcttcaag tgctctcctc cctcccgcca taatctggcc ccttcccgcc 3601 caccacccag actcacctgc gccaggcatc tcagccccat cttcctgcag actcacaaaa 3661 ggcagctgcc caagcagggc ctgacccctc ggtgtcccct ccccacagta ctgtgcagcc 3721 ctggaatccc tgatcaacgt gtcaggctgc agtgccatcg agaagaccca gaggatgctg 3781 agcggattct gcccgcacaa ggtctcagct ggggtaaggc atcccccacc ctctcacacc 3841 caccctgcac cccctcctgc caaccctggg ctcgctgaag ggaagctggc tgaatatcca 3gθl tggtgtgtgt ccacccaggg gtggggccat tgtggcagca gggacgtggc cttcgggatt 3g61 tacaggatct gggctcaagg gctcctaact cctacctggg cctcaatttc cacatctgta 4021 cagtagaggt actaacagta cccacctcat ggggacttcc gtgaggactg aatgagacag 4081 tccctggaaa gcccctggtt tgtgcgagtc gtcccggcct ctggcgttct actcacgtgc 4141 tgacctcttt gtcctgcagc agttttccag cttgcatgtc cgagacacca aaatcgaggt 4201 ggcccagttt gtaaaggacc tgctcttaca tttaaagaaa ctttttcgcg agggacggtt 4261 caactgaaac ttcgaaagca tcattatttg cagagacagg acctgactat tgaagttgca 4321 gattcatttt tctttctgat gtcaaaaatg tcttgggtag gcgggaagga gggttaggga 4381 ggggtaaaat tccttagctt agacctcagc ctgtgctgcc cgtcttcagc ctagccgacc 4441 tcagccttcc ccttgcccag ggctcagcct ggtgggcctc ctctgtccag ggccctgagc 4501 tcggtggacc cagggatgac atgtccctac acccctcccc tgccctagag cacactgtag 4561 cattacagtg ggtgcccccc ttgccagaca tgtggtggga cagggaccca cttcacacac 4621 aggcaactga ggcagacagc agctcaggca cacttcttct tggtcttatt tattattgtg 4681 tgttatttaa atgagtgtgt ttgtcaccgt tggggattgg ggaagactgt ggctgctggc 4741 acttggagcc aagggttcag agactcaggg ccccagcact aaagcagtgg accccaggag 4801 tccctggtaa taagtactgt gtacagaatt ctgctacctc actggggtcc tggggcctcg 4861 gagcctcatc cgaggcaggg tcaggagagg ggcagaacag ccgctcctgt ctgccagcca 4g21 gcagccagct ctcagccaac gagtaattta ttgtttttcc tcgtatttaa atattaaata 4g81 tgttagcaaa gagttaatat atagaagggt accttgaaca ctgggggagg ggacattgaa 5041 caagttgttt cattgactat caaactgaag ccagaaataa agttggtgac agataggcct 5101 gattgtattt gtctttcatt ttggcctttg gggacactgg tctgtggtct gaagactctg 5161 aggagctctt cgggaggctg gtgggttgga ggaggggact gggatggatt acagcgaggg 5221 tagggtgcag tgacctgggc tgaatgcaag ctagctcccg agggtgggga catggcctga 5281 aggaagcccc accttctgtc tgctgcacca gcaaggacgg agaggcttgg gccagactgt 5341 cagggttcaa ggagggcatc aggagcagac ggagacccag gaagtctcac aatcacatct 5401 cctgaggact ggccagctgt gtctggcacc acccacacat ccatgtctcc ctcacaaccc 5461 aggaggccga tgagaactgt gaggctcaga aagcgtgggc ggtttgccta aggtcacgta 5521 gctacttcct cactggggtc ctggggcctc agagcctcat ctgaggtaaa ggagcaaagt 5581 tgggattggg gtccaaaatt cactttaact ccaaagccca cacacttaac caccctgcct 5641 atttctgtcc aaatgtcacc tgtcctgaat

(2) INFORMATION FOR SEQ ID NO: 90: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14978 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 90: 1 ttcggcatcc gctcctcaat cctctcctgt tggcactggg cctcatggcg cttttgttga

61 ccacggtcat tgctctcact tgccttggcg gctttgcctc cccaggccct gtgcctccct

121 ctacagccct cagggagctc attgaggagc tggtcaacat cacccagaac cagaaggctc

181 cgctctgcaa tggcagcatg gtatggagca tcaacctgac agctggcatg tactgtgcag

241 ccctggaatc cctgatcaac gtgtcaggct gcagtgccat cgagaagacc cagaggatgc

301 tgagcggatt ctgcccgcac aaggtctcag ctgggcagtt ttccagcttg catgtccgag

361 acaccaaaat cgaggtggcc cagtttgtaa aggacctgct cttacattta aagaaacttt

421 ttcgcgaggg acggttcaac tgaaacttcg aaagcatcat tatttgcaga gacaggacct

481 gactattgaa gttgcagatt catttttctt tctgatgtca aaaatgtctt gggtaggcgg

541 gaaggagggt tagggagggg taaaattcct tagcttagac ctcagcctgt gctgcccgtc

601 ttcagcctag ccgacctcag ccttcccctt gcccagggct cagcctggtg ggcctcctct

661 gtccagggcc ctgagctcgg tggacccagg gatgacatgt ccctacaccc ctcccctgcc

721 ctagagcaca ctgtagcatt acagtgggtg ccccccttgc cagacatgtg gtgggacagg

781 gacccacttc acacacaggc aactgaggca gacagcagct caggcacact tcttcttggt

841 cttatttatt attgtgtgtt atttaaatga gtgtgtttgt caccgttggg gattggggaa

901 gactgtggct gctggcactt ggagccaagg gttcagagac tcagggcccc agcactaaag

961 cagtggaccc caggagtccc tggtaataag tactgtgtac agaattctgc tacctcactg

1021 gggtcctggg gcctcggagc ctcatccgag gcagggtcag gagaggggca gaacagccgc

1081 tcctgtctgc cagccagcag ccagctctca gccaacgagt aatttattgt ttttcctcgt

1141 atttaaatat taaatatgtt agcaaagagt taatatatag aagggtacct tgaacactgg

1201 gggaggggac attgaacaag ttgtttcatt gactatcaaa ctgaagccag aaataaagtt

1261 ggtgacagat tcagcccggc cgggctccga ggcgagaggc tgcatggagt ggccggcgcg gctctgcggg

61 ctgtgggcgc tgctgctctg cgccggcggc gggggcgggg gcgggggcgc cgcgcctacg

121 gaaactcagc cacctgtgac aaatttgagt gtctctgttg aaaacctctg cacagtaata

181 tggacatgga atccacccga gggagccagc tcaaattgta gtctatggta ttttagtcat EPI-109 1256

241 tttggcgaca aacaagataa gaaaatagct ccggaaactc gtcgttcaat agaagtaccc 301 ctgaatgaga ggatttgtct gcaagtgggg tcccagtgta gcaccaatga gagtgagaag 361 cctagcattt tggttgaaaa atgcatctca cccccagaag gtgatcctga gtctgctgtg 421 actgagcttc aatgcatttg gcacaacctg agctacatga agtgttcttg gctccctgga 481 aggaatacca gtcccgacac taactatact ctctactatt ggcacagaag cctggaaaaa 541 attcatcaat gtgaaaacat ctttagagaa ggccaatact ttggttgttc ctttgatctg 601 accaaagtga aggattccag ttttgaacaa cacagtgtcc aaataatggt caaggataat 661 gcaggaaaaa ttaaaccatc cttcaatata gtgcctttaa cttcccgtgt gaaacctgat 721 cctccacata ttaaaaacct ctccttccac aatgatgacc tatatgtgca atgggagaat 781 ccacagaatt ttattagcag atgcctattt tatgaagtag aagtcaataa cagccaaact 841 gagacacata atgttttcta cgtccaagag gctaaatgtg agaatccaga atttgagaga 901 aatgtggaga atacatcttg tttcatggtc cctggtgttc ttcctgatac tttgaacaca 961 gtcagaataa gagtcaaaac aaataagtta tgctatgagg atgacaaact ctggagtaat 1021 tggagccaag aaatgagtat aggtaagaag cgcaattcca cactctacat aaccatgtta 1081 ctcattgttc cagtcatcgt cgcaggtgca atcatagtac tcctgcttta cctaaaaagg 1141 ctcaagatta ttatattccc tccaattcct gatcctggca agatttttaa agaaatgttt 1201 ggagaccaga atgatgatac tctgcactgg aagaagtacg acatctatga gaagcaaacc 1261 aaggaggaaa ccgactctgt agtgctgata gaaaacctga agaaagcctc tcagtgatgg 1321 agataattta tttttacctt cactgtgacc ttgagaagat tcttcccatt ctccatttgt 1381 tatctgggaa cttattaaat ggaaactgaa actactgcac catttaaaaa caggcagctc 1441 ataagagcca caggtcttta tgttgagtcg cgcaccgaaa aactaaaaat aatgggcgct 1501 ttggagaaga gtgtggagtc attctcattg aattataaaa gccagcaggc ttcaaactag 1561 gggacaaagc aaaaagtgat gatagtggtg gagttaatct tatcaagagt tgtgacaact 1621 tcctgaggga tctatacttg ctttgtgttc tttgtgtcaa catgaacaaa ttttatttgt 1681 aggggaactc atttggggtg caaatgctaa tgtcaaactt gagtcacaaa gaacatgtag 1741 aaaacaaaat ggataaaatc tgatatgtat tgtttgggat cctattgaac catgtttgtg 1801 gctattaaaa ctcttttaac agtctgggct gggtccggtg gctcacgcct gtaatcccag 1861 caatttggga gtccgaggcg ggcggatcac tcgaggtcag gagttccaga ccagcctgac 1921 caaaatggtg aaacctcctc tctactaaaa ctacaaaaat taactgggtg tggtggcgcg 1981 tgcctgtaat cccagctact cgggaagctg aggcaggtga attgtttgaa cctgggaggt 2041 ggaggttgca gtgagcagag atcacaccac tgcactctag cctgggtgac agagcaagac 2101 tctgtctaaa aaacaaaaca aaacaaaaca aaacaaaaaa acctcttaat attctggagt 2161 catcattccc ttcgacagca ttttcctctg ctttgaaagc cccagaaatc agtgttggcc 2221 atgatgacaa ctacagaaaa accagaggca gcttctttgc caagaccttt caaagccatt 2281 ttaggctgtt aggggcagtg gaggtagaat gactccttgg gtattagagt ttcaaccatg 2341 aagtctctaa caatgtattt tcttcacctc tgctactcaa gtagcattta ctgtgtcttt 2401 ggtttgtgct aggcccccgg gtgtgaagca cagacccctt ccaggggttt acagtctatt 2461 tgagactcct cagttcttgc cacttttttt tttaatctcc accagtcatt tttcagacct 2521 tttaactcct caattccaac actgatttcc ccttttgcat tctccctcct tcccttcctt 2581 gtagcctttt gactttcatt ggaaattagg atgtaaatct gctcaggaga cctggaggag 2641 cagaggataa ttagcatctc aggttaagtg tgagtaatct gagaaacaat gactaattct 2701 tgcatatttt gtaacttcca tgtgagggtt ttcagcattg atatttgtgc attttctaaa 2761 cagagatgag gtggtatctt cacgtagaac attggtattc gcttgagaaa aaaagaatag 2821 ttgaacctat ttctctttct ttacaagatg ggtccaggat tcctcttttc tctgccataa 2881 atgattaatt aaatagcttt tgtgtcttac attggtagcc agccagccaa ggctctgttt 2941 atgcttttgg ggggcatata ttgggttcca ttctcaccta tccacacaac atatccgtat 3001 atatcccctc tactcttact tcccccaaat ttaaagaagt atgggaaatg agaggcattt 3061 cccccacccc atttctctcc tcacacacag actcatatta ctggtaggaa cttgagaact 3121 ttatttccaa gttgttcaaa catttaccaa tcatattaat acaatgatgc tatttgcaat 3181 tcctgctcct aggggagggg agataagaaa ccctcactct ctacaggttt gggtacaagt 3241 ggcaacctgc ttccatggcc gtgtagaagc atggtgccct ggcttctctg aggaagctgg 3301 ggttcatgac aatggcagat gtaaagttat tcttgaagtc agattgaggc tgggagacag 3361 ccgtagtaga tgttctactt tgttctgctg ttctctagaa agaatatttg gttttcctgt 3421 ataggaatga gattaattcc tttccaggta ttttataatt ctgggaagca aaacccatgc 3481 ctccccctag ccatttttac tgttatccta tttagatggc catgaagagg atgctgtgaa 3541 attcccaaca aacattgatg ctgacagtca tgcagtctgg gagtggggaa gtgatctttt 3601 gttcccatcc tcttctttta gcagtaaaat agctgaggga aaagggaggg aaaaggaagt 3661 tatgggaata cctgtggtgg ttgtgatccc taggtcttgg gagctcttgg aggtgtctgt 3721 atcagtggat ttcccatccc ctgtgggaaa ttagtaggct catttactgt tttaggtcta 3781 gcctatgtgg attttttcct aacataccta agcaaaccca gtgtcaggat ggtaattctt 3841 attctttcgt tcagttaagt ttttcccttc atctgggcac tgaagggata tgtgaaacaa 3901 tgttaacatt tttggtagtc ttcaaccagg gattgtttct gtttaacttc ttataggaaa 3961 gcttgagtaa aataaatatt gtctttttgt atgtcaccc tgccaaggct ccagcccggc cgggctccga ggcgagaggc tgcatggagt ggccggcgcg

61 gctctgcggg ctgtgggcgc tgctgctctg cgccggcggc gggggcgggg gcgggggcgc

121 cgcgcctacg gaaactcagc cacctgtgac aaatttgagt gtctctgttg aaaacctctg

181 cacagtaata tggacatgga atccacccga gggagccagc tcaaattgta gtctatggta

241 ttttagtcat tttggcgaca aacaagataa gaaaatagct ccggaaactc gtcgttcaat 301 agaagtaccc ctgaatgaga ggatttgtct gcaagtgggg tcccagtgta gcaccaatga 361 gagtgagaag cctagcattt tggttgaaaa atgcatctca cccccagaag gtgatcctga 421 gtctgctgtg actgagcttc aatgcatttg gcacaacctg agctacatga agtgttcttg 481 gctccctgga aggaatacca gtcccgacac taactatact ctctactatt ggcacagaag 541 cctggaaaaa attcatcaat gtgaaaacat ctttagagaa ggccaatact ttggttgttc 601 ctttgatctg accaaagtga aggattccag ttttgaacaa cacagtgtcc aaataatggt 661 caaggataat gcaggaaaaa ttaaaccatc cttcaatata gtgcctttaa cttcccgtgt EPI-109 1257

721 gaaacctgat cctccacata ttaaaaacct ctccttccac aatgatgacc tatatgtgca 781 atgggagaat ccacagaatt ttattagcag atgcctattt tatgaagtag aagtcaataa 841 cagccaaact gagacacata atgttttcta cgtccaagag gctaaatgtg agaatccaga 901 atttgagaga aatgtggaga atacatcttg tttcatggtc cctggtgttc ttcctgatac 961 tttgaacaca gtcagaataa gagtcaaaac aaataagtta tgctatgagg atgacaaact 1021 ctggagtaat tggagccaag aaatgagtat aggtaagaag cgcaattcca cactctacat 1081 aaccatgtta ctcattgttc cagtcatcgt cgcaggtgca atcatagtac tcctgcttta 1141 cctaaaaagg ctcaagatta ttatattccc tccaattcct gatcctggca agatttttaa 1201 agaaatgttt ggagaccaga atgatgatac tctgcactgg aagaagtacg acatctatga 1261 gaagcaaacc aaggaggaaa ccgactctgt agtgctgata gaaaacctga agaaagcctc 1321 tcagtgatgg agataattta tttttacctt cactgtgacc ttgagaagat tcttcccatt 1381 ctccatttgt tatctgggaa cttattaaat ggaaactgaa actactgcac catttaaaaa 1441 caggcagctc ataagagcca caggtcttta tgttgagtcg cgcaccgaaa aactaaaaat 1501 aatgggcgct ttggagaaga gtgtggagtc attctcattg aattataaaa gccagcaggc 1561 ttcaaactag gggacaaagc aaaaagtgat gatagtggtg gagttaatct tatcaagagt 1621 tgtgacaact tcctgaggga tctatacttg ctttgtgttc tttgtgtcaa catgaacaaa 1681 ttttatttgt aggggaactc atttggggtg caaatgctaa tgtcaaactt gagtcacaaa 1741 gaacatgtag aaaacaaaat ggataaaatc tgatatgtat tgtttgggat cctattgaac 1801 catgtttgtg gctattaaaa ctcttttaac agtctgggct gggtccggtg gctcacgcct 1861 gtaatcccag caatttggga gtccgaggcg ggcggatcac tcgaggtcag gagttccaga 1921 ccagcctgac caaaatggtg aaacctcctc tctactaaaa ctacaaaaat taactgggtg 1981 tggtggcgcg tgcctgtaat cccagctact cgggaagctg aggcaggtga attgtttgaa 2041 cctgggaggt ggaggttgca gtgagcagag atcacaccac tgcactctag cctgggtgac 2101 agagcaagac tctgtctaaa aaacaaaaca aaacaaaaca aaacaaaaaa acctcttaat 2161 attctggagt catcattccc ttcgacagca ttttcctctg ctttgaaagc cccagaaatc 2221 agtgttggcc atgatgacaa ctacagaaaa accagaggca gcttctttgc caagaccttt 2281 caaagccatt ttaggctgtt aggggcagtg gaggtagaat gactccttgg gtattagagt 2341 ttcaaccatg aagtctctaa caatgtattt tcttcacctc tgctactcaa gtagcattta 2401 ctgtgtcttt ggtttgtgct aggcccccgg gtgtgaagca cagacccctt ccaggggttt 2461 acagtctatt tgagactcct cagttcttgc cacttttttt tttaatctcc accagtcatt 2521 tttcagacct tttaactcct caattccaac actgatttcc ccttttgcat tctccctcct 2581 tcccttcctt gtagcctttt gactttcatt ggaaattagg atgtaaatct gctcaggaga 2641 cctggaggag cagaggataa ttagcatctc aggttaagtg tgagtaatct gagaaacaat 2701 gactaattct tgcatatttt gtaacttcca tgtgagggtt ttcagcattg atatttgtgc 2761 attttctaaa cagagatgag gtggtatctt cacgtagaac attggtattc gcttgagaaa 2821 aaaagaatag ttgaacctat ttctctttct ttacaagatg ggtccaggat tcctcttttc 2881 tctgccataa atgattaatt aaatagcttt tgtgtcttac attggtagcc agccagccaa 2941 ggctctgttt atgcttttgg ggggcatata ttgggttcca ttctcaccta tccacacaac 3001 atatccgtat atatcccctc tactcttact tcccccaaat ttaaagaagt atgggaaatg 3061 agaggcattt cccccacccc atttctctcc tcacacacag actcatatta ctggtaggaa 3121 cttgagaact ttatttccaa gttgttcaaa catttaccaa tcatattaat acaatgatgc 3181 tatttgcaat tcctgctcct aggggagggg agataagaaa ccctcactct ctacaggttt 3241 gggtacaagt ggcaacctgc ttccatggcc gtgtagaagc atggtgccct ggcttctctg 3301 aggaagctgg ggttcatgac aatggcagat gtaaagttat tcttgaagtc agattgaggc 3361 tgggagacag ccgtagtaga tgttctactt tgttctgctg ttctctagaa agaatatttg 3421 gttttcctgt ataggaatga gattaattcc tttccaggta ttttataatt ctgggaagca 3481 aaacccatgc ctccccctag ccatttttac tgttatccta tttagatggc catgaagagg 3541 atgctgtgaa attcccaaca aacattgatg ctgacagtca tgcagtctgg gagtggggaa 3601 gtgatctttt gttcccatcc tcttctttta gcagtaaaat agctgaggga aaagggaggg 3661 aaaaggaagt tatgggaata cctgtggtgg ttgtgatccc taggtcttgg gagctcttgg 3721 aggtgtctgt atcagtggat ttcccatccc ctgtgggaaa ttagtaggct catttactgt 3781 tttaggtcta gcctatgtgg attttttcct aacataccta agcaaaccca gtgtcaggat 3841 ggtaattctt attctttcgt tcagttaagt ttttcccttc atctgggcac tgaagggata 3901 tgtgaaacaa tgttaacatt tttggtagtc ttcaaccagg gattgtttct gtttaacttc 3961 ttataggaaa gcttgagtaa aataaatatt gtctttttgt atgtcaagcg ggccgccacc 4021 gcggtggaaa ctccagctt 1 ggatccccgc tgacaatcta gaaacaagca acagaccctc tgatgtagcc atctgtgccg

61 cgcctctccg caccgcccgc cacgccttgg tccctggaga ccaccctcca gggcaggggc 121 tgccgctcgg ccgggcccgc ggggtccctc ggcctgacat ggccggtgct ggagcggcac 181 gtgcgcgcct cggcccctcg gccgctcccg cccctcgccg gtgcgcaccg gcgctcgggg 241 agccgctggc ccgggtgtcc agccggccct tgccctgcct ggcgctcgga ccgccacctt 301 tgccgccccc tcgccagcct ccgcagcttc cagactggcc ggtctgcgcg cccacccctg 361 cctcccggac cggccaccgc cggaggccgc ggaggagggc ccggccgcgc agatcccgct 421 tatcgggccc catctcccgt tacataaggc caccccccta tctccgcggg ccatcgccgc 481 cgcaaccgcc gcgccagcgc cttctcccac gcgcgggggc gcccctgccc accgctcccg 541 gcagggcttt tggtggccat gggggataag gggcgttgac tcacccgggc ggggctccgg 601 gagttgcaca gaccaaggta gttccccgct ccttccccca tcacggagac cctgtgggag 661 atgccgtggg ccctctacta cagattagga aacaggcccg tagaggggtc gcgcggccaa 721 gtagcggcac tccaggcact gggggccctc gagggaaggg gcagacttct gggagtcaga 781 gccagcagct gggctgggaa gcttcgagtg tggacagaga gggtgggaat gacgttccct 841 gtgggaagag agggtgggca agcctgggat gcctctgagc gggaatccag catgccttgt 901 gaggagggtc acaagcacac ccttgtgagg aggttgagcc ccatcgagga caggacggag 961 ggagcctgag caggcagaga gggggcctgg ggaggcgctg gttcggggag gaagtgggta 1021 ggggagaaat cttgacatca acacccaaca ggcaaatgcc gtggcctctg ctgtgggggt 1081 ttctggagga cttctaggaa aacgagggaa gagcaggaaa aggcgacatg gctgtagggc EPI-109 1258

1141 caagcccagg agccgccctc cacagcactc attctgcaga agggaaattt gaggccccca 1201 gacggcaggg gttgatcctg cagagactgg tgagcaaagg ggatcacccc aagccccagt 1261 ggcactagga acacttacaa tctctgacct ggactaaggc tgccagcctg gcccagttaa 1321 gagtttccca gaaggatggc ccatacactt taaattaaag gggccagaca cgtgcacact 1381 acttccagcc actctggaag ctgaggtggg gggatcgctt gagtctggga gttggaggcc 1441 agcctaggca ggcaacatag tgagacccca tctccaaaaa aacaaaacaa aacaaaacaa 1501 aaaaacacca aaaaagctcc cagaaagacc tctgaatctt tctggatctc tcagtggaga 1561 cctggaaatc tgaactttga caatccctct cacagtgggg ccaaggagga attaggcaag 1621 ccaaaagaag tgaactttac tcttctattg cctgtttgaa ttttgtatcc aagcaagtgt 1681 tacttaagta atttaagaga ctggttcatc gaaaaaataa aactccccaa attcccatag 1741 ctggtagact gtggtcacag ccacagtgca ctaagactat ctgctcagca cttctggtga 1801 cccaaaaggg tctgaggaca ggagctcaga gttgggtcag ctgtccaggt actcagggtt 1861 gtcacaggca aaactgctgg aactcagggc agcattgcaa atgccacgcc gctctcaggg 1921 ccccttgcct gccgctggaa ttaaacccac ccagatcttg gaaactctgc cctggaccct 1981 tctcaataag tccatgagaa atcaaactct ttcctttatg cgacactgga ttttccacaa 2041 agtaaaatca agatgagtaa agatgtggtt tctagatagt gcctgaaaaa gcagagacca 2101 tggtgtcagg cgtcaccact tgggcctata aaagctgcca caagacgcca aggccacaag 2161 ccacccagcc tatgcatccg ctcctcaatc ctctcctgtt ggcactgggc ctcatggcgc 2221 ttttgttgac cacggtcatt gctctcactt gccttggcgg ctttgcctcc ccaggccctg 2281 tgcctccctc tacagccctc agggagctca ttgaggagct ggtcaacatc acccagaacc 2341 agaaggtgag tgtcggctag ccagggtcct agctatgagg gctccagggt gggtgattcc 2401 caagatgagg tcatgagcag gctgggcctg gtcctaagat gcctgtaggt caggaaaaat 2461 ctccatggac caaggcccgg cccagccatg agggagagag gagctgggct ggggggctca 2521 gcactgtgga tggacctatg gaggtgtctg gcagactccc cagggactac ctgctctcct 2581 ggcctggcct tgtctgccac tgccagctcc tactcagcca ttcctgaaca gaggacagca 2641 gagaagggcc agcaccctcc cagaaccatg tggcatttgc caactggatt ttgaccataa 2701 caatgcagcc attctcccca gcaccatcat aggcccgccc ttacaggagg attcgttagt 2761 agagtccgct ccttgcccca ctagtaacag ctcacatgtc tgagcactgc ttacaccagg 2821 cctggtgcac gtgctttatg tgtcatttca tcactgccag ccacctcaag aggcaggtac 2881 gatgaaccca ttctgctaag gttcagtgag gttaagtgac agaggctgga ttcaagccag 2941 gcctggccaa caccagagtg tccatgctcc taactgcagt gttccctcac catcagaagg 3001 cagggcattt aatacaccag atccccaccg cctcccatct gatttgtctt ggtcaacagt 3061 ggcccaggcc actcctactt cactcgtccc caccctggcc cttcccgcag gcccctgtcc 3121 tcctgccctg actatggcaa gccttgcatg cagcttgtcc cttactagtg gtgtcaattt 3181 ttttctctca gctccaagac cctaaacagt gggacctcac ccctatgcct gctgttcaaa 3241 gcagaaaacg aagctcagga atgctgaggg gctgccaggc ctgcctctgt gccacaccag 3301 ggatgcttgt ggggcctgtg ctggggcaga cctggcctgg gctgccaggg caggcccaca 3361 acccctgcca gcactctgct cactgtcact ttgctcccac aggctccgct ctgcaatggc 3421 agcatggtat ggagcatcaa cctgacagct ggcatggtaa ggacctttgg gtgcagggag 3481 gatggggcag aggctccagg ccttgggctt atcttctctg agcctccctt ccatggctgg 3541 ggttccaagc aagcttcaag tgctctcctc cctcccgcca taatctggcc ccttcccgcc 3601 caccacccag actcacctgc gccaggcatc tcagccccat cttcctgcag actcacaaaa 3661 ggcagctgcc caagcagggc ctgacccctc ggtgtcccct ccccacagta ctgtgcagcc 3721 ctggaatccc tgatcaacgt gtcaggctgc agtgccatcg agaagaccca gaggatgctg 3781 agcggattct gcccgcacaa ggtctcagct ggggtaaggc atcccccacc ctctcacacc 3841 caccctgcac cccctcctgc caaccctggg ctcgctgaag ggaagctggc tgaatatcca 3901 tggtgtgtgt ccacccaggg gtggggccat tgtggcagca gggacgtggc cttcgggatt 3961 tacaggatct gggctcaagg gctcctaact cctacctggg cctcaatttc cacatctgta 4021 cagtagaggt actaacagta cccacctcat ggggacttcc gtgaggactg aatgagacag 4081 tccctggaaa gcccctggtt tgtgcgagtc gtcccggcct ctggcgttct actcacgtgc 4141 tgacctcttt gtcctgcagc agttttccag cttgcatgtc cgagacacca aaatcgaggt 4201 ggcccagttt gtaaaggacc tgctcttaca tttaaagaaa ctttttcgcg agggacggtt 4261 caactgaaac ttcgaaagca tcattatttg cagagacagg acctgactat tgaagttgca 4321 gattcatttt tctttctgat gtcaaaaatg tcttgggtag gcgggaagga gggttaggga 4381 ggggtaaaat tccttagctt agacctcagc ctgtgctgcc cgtcttcagc ctagccgacc 4441 tcagccttcc ccttgcccag ggctcagcct ggtgggcctc ctctgtccag ggccctgagc 4501 tcggtggacc cagggatgac atgtccctac acccctcccc tgccctagag cacactgtag 4561 cattacagtg ggtgcccccc ttgccagaca tgtggtggga cagggaccca cttcacacac 4621 aggcaactga ggcagacagc agctcaggca cacttcttct tggtcttatt tattattgtg 4681 tgttatttaa atgagtgtgt ttgtcaccgt tggggattgg ggaagactgt ggctgctggc 4741 acttggagcc aagggttcag agactcaggg ccccagcact aaagcagtgg accccaggag 4801 tccctggtaa taagtactgt gtacagaatt ctgctacctc actggggtcc tggggcctcg 4861 gagcctcatc cgaggcaggg tcaggagagg ggcagaacag ccgctcctgt ctgccagcca 4921 gcagccagct ctcagccaac gagtaattta ttgtttttcc tcgtatttaa atattaaata 4981 tgttagcaaa gagttaatat atagaagggt accttgaaca ctgggggagg ggacattgaa 5041 caagttgttt cattgactat caaactgaag ccagaaataa agttggtgac agataggcct 5101 gattgtattt gtctttcatt ttggcctttg gggacactgg tctgtggtct gaagactctg 5161 aggagctctt cgggaggctg gtgggttgga ggaggggact gggatggatt acagcgaggg 5221 tagggtgcag tgacctgggc tgaatgcaag ctagctcccg agggtgggga catggcctga 5281 aggaagcccc accttctgtc tgctgcacca gcaaggacgg agaggcttgg gccagactgt 5341 cagggttcaa ggagggcatc aggagcagac ggagacccag gaagtctcac aatcacatct 5401 cctgaggact ggccagctgt gtctggcacc acccacacat ccatgtctcc ctcacaaccc 5461 aggaggccga tgagaactgt gaggctcaga aagcgtgggc ggtttgccta aggtcacgta 5521 gctacttcct cactggggtc ctggggcctc agagcctcat ctgaggtaaa ggagcaaagt 5581 tgggattggg gtccaaaatt cactttaact ccaaagccca cacacttaac caccctgcct EPI-109 1259

5641 atttctgtcc aaatgtcacc tgtcctgaat

( 2 ) INFORMATION FOR SEQ ID NO : 91 : ( l ) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 1793 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 91: 1 caacaccttc agaaataatc ctttgggtga tctcttgtca atcatttgtg caggctagag

61 aggcacctgt gaatgataag gctactgaga agcatcattg gcctggtcct ggcactacca

121 aagggcaggg gaagcgatgc ccaaggggct cctgaccagc acatcatccc acgcaaaaac

181 attctccagg tcccttgttc caggcaggaa atccccagct ctgagcgccc tgccagggct

241 ctgcctaggg acaccttttc caggtctaga gaatcaaagg agcctccaga gcagctagga

301 gggcctgagc tgaccaagca agccctgctc acaagacaaa tgcagtcaag acctgggtgt

361 attacttgtc ttgagctctg aagggcaggg aggggtctga gcctcaaatc agacagagaa

421 atgctcaagt cacttctgcc aactcactgt gatggcagct acagatgaca gcccctctca

481 agactcttca gctcacagac aagccactga cttcatctgt acacaccccc atccccaatg

541 caagcccact gtacacttac aggtataaat gcatttgcaa ggccttgcaa aatgccctat

601 gtacgtaaaa ctgacccaca aaatccaaaa ttgcaagtgc cagatgccag ccaggtcaga

661 acatcctggc ttcagcaatg ggctgctcag catgggagcc ttttatgggc caggcctggc

721 tgggctgccg ctcccttccc agcatgaccc aacaccaggc tctctaggcc ctggcggagg

781 tgggctcttg aggcccagtc tggcctgatg cttctgtgct cggtgctcct gggtagcaag

841 gcgcttctgt gaccctgggg gagctgggtg cttgagcccc aggcccctct ggcctcctct

901 cagggccact gtcagtgagg gagccctggc caccagcact caggtcctgt accctcttgt

961 tcaggtcatt gcgctctgtc tgcagtgccc ggcacagctt ctccagccgt tggattttta

1021 cctgcaggcc ctccagttct ttatcccgga ctgttttctc ctcagccatc tcaagcaggg

1081 ccttgttgct gctctcccac cgggaccggt acatggtggt ttctttctcc agcttcttga

1141 tcttcttagt catcttttcc atctcctgct tgaatgtggt gaatacctcg ctgcttttgg

1201 aaagtgtgtt ctggaactcc tcaaacttct ctgtgtatag ggcaagctgt tgcttcaggt

1261 gggtctcttg ctgcttcatc agctcacaca tcctctggga ctctactgcc tctttcagga

1321 gaaaatcctt ctcccgctgg tgccgctctt ctgcctcctt tagcatctcc tgggcctgct

1381 ggagcttggc atccaccagc tgctgttgta ggtccttgtg tttgaagact ttgtcgatat

1441 gctcctcgcg cagctcatac tgctcaatca gcttcttgag cctctcagcc agctccatgt

1501 tctcttggcg cagcttggag ttgcgctcat tgtgctgttc catctgcagc tgaatgtcat

1561 tcagtgtcac ctggaagtgc gaggtcacct ccttgcgctt ctcctcctcc tcccgggccc

1621 gctgcacacc ttcttccttg agggagcggt tgtgcccgtg cagctcacgg cataggctct

1681 caagcttgct gcgggccagg acggcttgct gtgctcaccg cgcaggtggt ccttctcttg

1741 caccagctgg ctctgctttt tctgtaggag cttcatctgc ttctgtgaat tec

(2) INFORMATION FOR SEQ ID NO: 92: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1793 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 92: 1 caacaccttc agaaataatc ctttgggtga tctcttgtca atcatttgtg caggctagag

61 aggcacctgt gaatgataag gctactgaga agcatcattg gcctggtcct ggcactacca

121 aagggcaggg gaagcgatgc ccaaggggct cctgaccagc acatcatccc acgcaaaaac

181 attctccagg tcccttgttc caggcaggaa atccccagct ctgagcgccc tgccagggct

241 ctgcctaggg acaccttttc caggtctaga gaatcaaagg agcctccaga gcagctagga

301 gggcctgagc tgaccaagca agccctgctc acaagacaaa tgcagtcaag acctgggtgt

361 attacttgtc ttgagctctg aagggcaggg aggggtctga gcctcaaatc agacagagaa

421 atgctcaagt cacttctgcc aactcactgt gatggcagct acagatgaca gcccctctca

481 agactcttca gctcacagac aagccactga cttcatctgt acacaccccc atccccaatg

541 caagcccact gtacacttac aggtataaat gcatttgcaa ggccttgcaa aatgccctat

601 gtacgtaaaa ctgacccaca aaatccaaaa ttgcaagtgc cagatgccag ccaggtcaga

661 acatcctggc ttcagcaatg ggctgctcag catgggagcc ttttatgggc caggcctggc

721 tgggctgccg ctcccttccc agcatgaccc aacaccaggc tctctaggcc ctggcggagg

781 tgggctcttg aggcccagtc tggcctgatg cttctgtgct cggtgctcct gggtagcaag

841 gcgcttctgt gaccctgggg gagctgggtg cttgagcccc aggcccctct ggcctcctct

901 cagggccact gtcagtgagg gagccctggc caccagcact caggtcctgt accctcttgt

961 tcaggtcatt gcgctctgtc tgcagtgccc ggcacagctt ctccagccgt tggattttta

1021 cctgcaggcc ctccagttct ttatcccgga ctgttttctc ctcagccatc tcaagcaggg

1081 ccttgttgct gctctcccac cgggaccggt acatggtggt ttctttctcc agcttcttga

1141 tcttcttagt catcttttcc atctcctgct tgaatgtggt gaatacctcg ctgcttttgg

1201 aaagtgtgtt ctggaactcc tcaaacttct ctgtgtatag ggcaagctgt tgcttcaggt

1261 gggtctcttg ctgcttcatc agctcacaca tcctctggga ctctactgcc tctttcagga

1321 gaaaatcctt ctcccgctgg tgccgctctt ctgcctcctt tagcatctcc tgggcctgct

1381 ggagcttggc atccaccagc tgctgttgta ggtccttgtg tttgaagact ttgtcgatat

1441 gctcctcgcg cagctcatac tgctcaatca gcttcttgag cctctcagcc agctccatgt EPI-109 1260

1501 tctcttggcg cagcttggag ttgcgctcat tgtgctgttc catctgcagc tgaatgtcat

1561 tcagtgtcac ctggaagtgc gaggtcacct ccttgcgctt ctcctcctcc tcccgggccc

1621 gctgcacacc ttcttccttg agggagcggt tgtgcccgtg cagctcacgg cataggctct

1681 caagcttgct gcgggccagg acggcttgct gtgctcaccg cgcaggtggt ccttctcttg

1741 caccagctgg ctctgctttt tctgtaggag cttcatctgc ttctgtgaat tec

(2) INFORMATION FOR SEQ ID NO: 93: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1248 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 93: 1 aaatcctggc tgtcatgtac ttgctatggg cctagagtag cttacctaaa tgctactaac

61 cttcctccat accattattg taaagattaa aggtgatgca tctgttaagt aactaataga

121 gtgcttatta aaaggtaggt gttcaataag tattaattcc ctccctttct ttttcttact

181 agtgcacttg tgtttttaat ggatcatact ttaccctaga ttgtattgta ggaggcatcg

241 tggatggatg gctgctggaa accccttgcc atagccagct cttcttcaat acttaaggat

301 ttaccgtggc tttgagtaat gagaatttcg aaaccacatt tgagaagtat ttccatccag

361 tgctacttgt gtttacttct aaacagtcat tttctaactg aagctggcat tcatgtcttc

421 attttgggat gcagctaata tacccagttg gcccaaagca cctaacctat agttatataa

481 tctgactctc agttcagttt tactctacta atgccttcat ggtattggga accatagatt

541 tgtgcagctg tttcagtgca gggcttccta aaacagaagc caactgggtg aatgtaataa

601 gtgatttgaa aaaaattgaa gatcttattc aatctatgca tattgatgct actttatata

661 cggaaagtga tgttcacccc agttgcaaag taacagcaat gaagtgcttt ctcttggagt

721 tacaagttat ttcacttgag tccggagatg caagtattca tgatacagta gaaaatctga

781 tcatcctagc aaacaacagt ttgtcttcta atgggaatgt aacagaatct ggatgcaaag

841 aatgtgagga actggagaaa aaaaatatta aagaattttt gcagagtttt gtacatattg

901 tccaaatgtt catcaacact tcttgattgc aattgattct ttttaaagtg tttctgttat

961 taacaaacat cactctgctg cttagacata acaaaacact cggcatttca aatgtgctgt

1021 caaaacaagt ttttctgtca agaagatgat cagaccttgg atcagatgaa ctcttagaaa

1081 tgaaggcaga aaaatgtcat tgagtaatat agtgactatg aacttctctc agacttactt

1141 tactcatttt tttaatttat tattgaaatt gtacatattt gtggaataat gtaaaatgtt

1201 gaataaaaat atgtacaagt gttgtttttt aaaaaaaaaa aaaaaaaa

(2) INFORMATION FOR SEQ ID NO: 94: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1202 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 94: tgtccggcgc cccccgggag ggaactgggt ggccgcaccc tcccggctgc ggtggctgtc

61 gccccccacc ctgcagccag gactcgatgg agaatccatt ccaatatatg gccatgtggc

121 tctttggagc aatgttccat catgttccat gctgctgctg acgtcacatg gagcacagaa

181 atcaatgtta gcagatagcc agcccataca agatcgtatt gtattgtagg aggcatcgtg

241 gatggatggc tgctggaaac cccttgccat agccagctct tcttcaatac ttaaggattt

301 accgtggctt tgagtaatga gaatttcgaa accacatttg agaagtattt ccatccagtg

361 ctacttgtgt ttacttctaa acagtcattt tctaactgaa gctggcattc atgtcttcat

421 tttgggctgt ttcagtgcag ggcttcctaa aacagaagcc aactgggtga atgtaataag

481 tgatttgaaa aaaattgaag atcttattca atctatgcat attgatgcta ctttatatac

541 ggaaagtgat gttcacccca gttgcaaagt aacagcaatg aagtgctttc tcttggagtt

601 acaagttatt tcacttgagt ccggagatgc aagtattcat gatacagtag aaaatctgat

661 catcctagca aacaacagtt tgtcttctaa tgggaatgta acagaatctg gatgcaaaga

721 atgtgaggaa ctggaggaaa aaaatattaa agaatttttg cagagttttg tacatattgt

781 ccaaatgttc atcaacactt cttgattgca attgattctt tttaaagtgt ttctgttatt

841 aacaaacatc actctgctgc ttagacataa caaaacactc ggcatttaaa atgtgctgtc

901 aaaacaagtt tttctgtcaa gaagatgatc agaccttgga tcagatgaac tcttagaaat

961 gaaggcagaa aaatgtcatt gagtaatata gtgactatga acttctctca gacttacttt

1021 actcattttt ttaatttatt attgaaattg tacatatttg tggaataatg taaaatgttg

1081 aataaaaata tgtacaagtg ttgtttttta agttgcactg atattttacc tcttattgca

1141 aaatagcatt tgtttaaggg tgatagtcaa attatgtatt ggtggggctg ggtaccaatg

1201 ct

(2) INFORMATION FOR SEQ ID NO: 95: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14928 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 95: 1 ggcattgtaa tcagacagaa ctggcctcaa atcctggctg tcatgtactt gctatgggcc

61 tagagtagct tacctaaatg ctactaacct tcctccatac cattattgta aagattaaag 121 gtgatgcatc tgttaagtaa ctaatagagt gcttattaaa aggtaggtgt tcaataagta EPI-109 1261

181 ttaattccct ttctttcttt ttcttactag tgcacttgtg tttttaatgg atcatacttt 241 accctagatt gtattgtagg aggcatcgtg gatggatggc tgctggaaac cccttgccat 301 agccagctct tcttcaatac ttaaggattt accgtggctt tgagtaatga gaatttccgg 361 taagaagaaa aatagatgaa aatatcctat ggaatttccc ttaaaggtcg tctgaatctc 421 agagtctttg caataagtta catggttatt ctccaaagat cttgagatat cacagatgtc 481 tgttcacatt tggattgttc ttattttgaa aataaatagg tttttaaaaa ctctattgac 541 catcttgata ggctcttctt gtcattataa atgtgttatt tcacttatcc cactcttttg 601 tgttctctaa atgtctttgt actcactaaa ttgtgtagtc ttagagggca gggtgtgggt 661 atcattcatc tttttgaaag gaagcatgaa caattagtgg ttaaggtggc agttaacact 721 gctttctgaa actttaaaag cttcgacaac acaaaagagg caggtgaaag taccaaaact 781 ctggtaagtt gtaggataaa tgattttcct aaatcaccaa gaaagattat tagtcactct 841 caagatggaa tacagtatct gtaattggtt ccattttatc caatttttca ccaaataata 901 ttaatataat tcattttcat aatttacatg aagttaatat aactattgca tctctgttag 961 taatgcatgt tattaacctg tgctgtataa aatattttga cctattaaaa aagaaagaag 1021 gatgaggagg aggtcaaaga taatataaaa actttaagtg gtgacattgg tatgtatgta 1081 aattaacaaa tatgtcaact ttgttaaatt atctttgaca tgcatctgca gaaatatctg 1141 ttaaggaact ttgtgcataa gagacagagt tggaggtggg agagaaagtg aaaaaagata 1201 aattatagtt ttattatttt tgataagggg cagtaattat gaaattatga caaacttaca 1261 tctttagacc tagaaatatg ttgacatgtt attttaaacc tcacttttta actaaaaaat 1321 ttaaccattt gtctatgatt atatttttca gaaaccacat ttgagaagta tttccatcca 1381 gtgctacttg tgtttacttc taaacagtca ttttctaact gaagctggca ttcatgtctt 1441 cattttgggg gtaattttat ctttaggcat aaataacatt atgttcatgg tcatgatgat 1501 tgtccttgga tatattttcc attaaattag tttacgttca gtttgcttat atctctaggt 1561 actcagtatc tgggggatag aaggcagact acagagattt agagaggttt ggtaaacacc 1621 taactgagca tttttctaca ttgtggtaat agtccaaaca agcattatag ccctcaaata 1681 aattgggcct tttgatattt aactgaactt ggaagtatac cacttattga tagactacat 1741 atttttcatg gcaattaaaa gtagatattt agaatttgct tatgttactt ttttatctgt 1801 ccctgacact gactcctcct atcccttgat ctttatccta gttcagttta aaacatttct 1861 ttctttattt aagccttttg ttgtttcctt ctaataaaat tcatatgttt ccatgactat 1921 taactttttt cttctctctt agatgcagct aatataccca gttggcccaa agcacctaac 1981 ctatagttat ataatctgac tctcagttca gttttactct actaatgcct tcatggtatt 2041 gggaaccata gatttgtgca ggtaattctt catcataaga cagattagtg ttgactatca 2101 tgcttctgtg taagatccat caggaagtga gtgattattt ttcctcaagc tctaagcatc 2161 attccaatgt tacttggtca gtataagtgt attttgtctg gatattaaat tttaattttt 2221 atgaaatttg tgaaagtgag taagtatatg atcattcagc ctacactgga atgaagtctg 2281 tactgtttat ggagaaagct gctgcaagca tagtaagagt gtgagcaaca tgaaaggggc 2341 atgtttaatg tagtgtaaaa aaaatttact atcaaaatca ttacatgaaa atgattatta 2401 ctcattttaa gaattttacc tatttattag acttcaaagt ctctgtaaat ctctacttaa 2461 aggaaactag taattcattc aaaatcattt attgagcatt gccacacatc tggcactgct 2521 tctatttcat tgtgataaat tgagccagtt tatttataaa gtatgcctac agttaggctt 2581 ttctctaatc cgggttggtg aagcctcaag ttatcataaa atgccaaaat tgtactatat 2641 gctcaatgtt tatgttcagt tacaaggctg ttgaatgcac agaagcaagg ataacactga 2701 ttttttcact ggtcagaata aaaattattg attgctcttt tgcttatagt attcatcaag 2761 atgaataggc tccttcaaaa tgctttgctc tatggttttt ctttcagctg tttcagtgca 2821 gggcttccta aaacagaagc caactgggtg aatgtaataa gtgatttgaa aaaaattgaa 2881 gatcttattc aagtgagtac tcatttttcc ataaaatgcc tggtataact gctatggagt 2941 ttgtctctct ctgtgttttt ctgtctgtct taaggaaacc acacttgaaa caataatatt 3001 tttgtagaaa tttatgatct tataaagctc aaaaagaagt cttttcctta ctgttttaga 3061 atctaattat ctttaaaacg taatttataa gcggcccaga cggatgagtt ctagtctgca 3121 caggtgaggt attctcttcc tctatctgga gaagccagat atcttggtgg cacctgcagg 3181 gagaatggct tgacccaggg aacagctgtt gttgcttgtg gactaaaggc cctcttctcc 3241 cacctcaaga aaacaggtgg cctgacctaa ggaagtgatt tttgccatag caggtaatac 3301 cagcttcagt ggaagtctcg atggcaccaa gcataccaaa atagcaccac aaagttctga 3361 aaactaaatt gtcattggaa tcacagcatt aaaaaatagg ttagaacttg catgctaaat 3421 ccaaacaacc tgactgcatg ttaaaataga agatttaaat aggaccagag tgtcctaaca 3481 taatagacat gaagccaaga tacaattgga aatcacccat tgtaacaaga aataggaaag 3541 ttacaactta aatgagaaaa tatagtcaac agattacaaa attgaagtgg atcagatgtt 3601 ggaattctct gacatagatt tgaaagcaga cattataaaa agtgcttgaa aaagcaatta 3661 caaatgccct tgaagcaaat gaaaaactaa atgccttaac aaagaaatag aagatatgaa 3721 aggaaccata tagaaattat ataactgaaa atataactga aatataaagc aaactgtaaa 3781 ggctcattag cagaatgaat gacagaggaa tgatagttaa tttgacaaca gaatactaga 3841 gagacagttg acttaagaaa aaaaaagcat cactgatctt gacgacagta acaaaagatt 3901 cagcattcct atggttagta tcacaggaga gtatgagaat acaccaagta aaagagagag 3961 attggttgaa ttcataacaa aacaccaccc atctatacta tctataagca gttcacttct 4021 agtacaatga catacatagg ttgaaattta aaaagacaga aaaagatata gcatactata 4081 atgggttgaa tagtgtcccc ccaaatttca catcctcttg gaaccttaaa atgtgatctt 4141 attttgaaat aatatctttg caaatataat taatgaaatt aagatgagat catactagag 4201 tagggggggc cctaaatcca atgacaagtg tctttattag aaaaggaaag gacacagagt 4261 aactcactgg gaagaaagcc atgtgaagac agaggaagag atcagagtga tgcggctata 4321 agccaaggaa ggccagagat tgccaggatc caccagaacc ttggggaagt caagaaagca 4381 ttcttctcta gactgataca catgcataca ttaattataa aaagcagaag tggctatatt 4441 aacatcaaag ttaatgttat taacataaag tagacttcac agaaaataaa gttgctataa 4501 tccagaggga tattacaaaa tgataaaaaa taaatctgtg aggaaaacat aatgttctta 4561 aatgtataca catcaaacaa cgaagactca aaatttgtga aacaaaaaat aatagggata 4621 aaagagaaat agacaaatcc acaattattc ttgaggactt cactgcctcc tcctcagtaa 4681 ctaatggaag tactagacag aaaatcagaa agggcataaa aatacaatat aaccaaccaa

4741 caggatctaa tttaatacat agagcactac acccaacaac agcagaatat actttctttt

4801 atcaagacta aatatatact gagccataaa agaaacttta aaaatttttt cagaacttaa

4861 atcatgcaga atttgttctc aaaccacaat ggaatcaaac cagaaatcaa gaaattaaat

4921 acaacgggca aatctccaaa tgcttggaaa ttaaatacta tacctctata taatccatgg

4981 gtcaaagagt aaatctcaaa ggatattcat aatacataga atgaaaaaaa atgaaataca

5041 gcatatcaag atatatgtga tgtggctaaa gcaatactga caggacattt tttaaaatca

5101 aatgaataca ttagaaaaaa aggagaatta tcaaatcaaa aatctaagtt actgcttcaa

5161 gaaactagaa gaagtagagc aaaacaaatt caatacaagc agaacaaaga aaatatttaa

5221 atataagagc caaaattaat gaagttgaaa tcaagaaaac aatagaaaaa attaatgaaa

5281 cataaaactg gttatttgga aaatcaatac aattgatctt taattgacag aaataagaga

5341 gaagacacaa atctcaggaa tgaaatttgg ggctgtcact acagaatctg cagtcattag

5401 aaggataata agaaaaacta tgaacaattt tatgctcaca aatctgataa cttagaggaa

5461 atggaccaat tcttcagaaa ccacaaacta ccaaaacata atgaagatga aatagacaat

5521 ccaaacactc atataatcac taaatacatt gaattcatca tacacaagct cccaaaaagg

5581 gaccttcaag cctgctggtt acactgaatc attctatcaa atatttacag aagcattaac

5641 aacaattgta cagtctcttc tagaaaatag aagaggaagg aacattttcc agttgatttt

5701 aggaggccag tattactgtg atgctaaaac caaataaaga tattactaaa aaagacaact

5761 acaaaaatat ctcccattaa cttagatatt aaaatgctct ataaaatatt aacaaatcga

5821 attcagcaat gtataaaaag aattatacac catgaccgag tgagatttat ttcaggtaca

5881 caagtcttgc tcaattattt gaaagtcaag caatgtaatc taccctatca acaggctaaa

5941 gaagaaaatc atatgtagaa aaggtatctg ataaaatgca acacctctca tggcctgtgt

6001 ccctccctat gcctcctgga tttatatgtt gaagtactaa ttgccagtat atcaaaatgt

6061 gactgtattt tgagataggg tcagttaaaa tgaggtcatg agggcaggtc ctactgcaat

6121 atgactggta tctttagaaa aacagataag ggtatagata cacagagata gaaaaccatg

6181 tgaagacact gggagaaaat ggccacctat aagccaagga gggaggactc caaagaaacc

6241 aacactgctg gtaccctgat ttcagacctc tagcctcctg aattgtgaga aaataaagtt

6301 ctattattta agtcaccaag tctgtggtac tttttatagc agccctagca gactgatata

6361 aacacctatt gaagataaaa tttcttagaa agtaggtgtg gagaactgcc tcaacttggt

6421 acaaaacatg ttcaaaaagt ctagagctac catacttaat ggtgagtaca agactgaatg

6481 tttttctgct aggactggaa actaagcagg gatatcttct ctcaccactt ttactcaaca

6541 taattgtctg agttttctgt tgcttataac agagtacttg aaatgcataa tttataaaga

6601 aaggaattta tgtcttatgg ttatgagact gaaaagttca aggttgagga gccacatctg

6661 gtgagggcct tcctgctggt gggggctctc tggagtccag aggtgacaaa aagcatcaca

6721 tggcgagggg ctgaatgtac tcatgtgcta gctcaggtct ctcttcctct tcttataaaa

6781 ctaccggttc cctttccgta ataacacatt gatactctaa tccattcatg agggcagagc

6841 cattgtgatc caattacctc ttaaagcccc acctctcaat actgccacat tggggattaa

6901 gtttcaatct gaattttgga ggggacattc aaaccacagc aataatattg gaagtttagc

6961 caaattatga agcaggagag aaaaaatgta tgagaaaaaa ataaataaaa ggcacacaga

7021 ttggaaagga aaattataca tcaccccaag ttttttggag agaaagtagt aaaaatgggt

7081 atattttgtt tagaaagtaa tgcaaattaa aaccacaatg acatattatt acatgcagct

7141 ataagcgtat acagaataaa aaatagtgat gatgctaagt aaatataaat gaacaagggt

7201 gataatgctg gcaaggatgt ggagaaactg gatcattcat acattgctgg tgatgatgta

7261 aaatgataca ggcactgtat aaaatagttt ggcagcatcc tatgaaacaa aacatgcatt

7321 tgccttacaa tccaacaatt gtgctcttag acattcatcc ttgataaatg aaaactacgt

7381 gcacacaaaa atatgtacat gaatgttcac agagattttt tcatgactgc caaaaactgg

7441 aaacagatgt gcttcagttg gtaaaatctg tgatatatca tgtcagggaa tactacagag

7501 caataaaaag gaacaaacta gtgataccca caagttaggt ggatctccag ggtattatga

7561 tgagtgaaaa aagccagtct tcataaagaa actgtggtac atttataaaa tagaatatta

7621 tccagtgata aaaagaaata agctatcaag ccatgaaaag aaatggagaa accttcaaag

7681 tcatattgtt gagtgaaaga tggggacgcc aatctgaaaa ggcttcacac tgtatgatcc

7741 caactatgac attttgaaaa aggcaaagct atggagacaa taaaaagatc agtggttgtt

7801 aggggtttgg agggaaggag aaatggctag gcagagcaca ggctactttt aaagcagtga

7861 aaatattaat atatgatgat gggtggcatt atacatttgt caaaacctgt aaaacataca

7921 acacaaataa tgagccctaa tattctgtac acttaagatc ataatagtga ttcaccaact

7981 ataacaaaca caccacacta atgcaagata ttaacaatag ggaaactggg gtggagaaca

8041 aaggggtgta taagtctctg tactttctgc tagtttttct gtaaacctaa atggctcata

8101 aaaatgtcta tcaattcttt taaaagctaa tttcagaagg ttacatatga tatgagtccg

8161 tttacataat attcttgaaa tgacaaaatt ataggcatgg agagcagaga agtggttgcc

8221 agaatttaga gagattgggt gatgatgagg tatgtatggg gagaaaggtg actttggtta

8281 tgaaagaata gcagcagaat ccttgtggtg atgaaactat tttgtgtctt aactgtggtg

8341 gtggtgatgt gaatctatgc aaatgataaa attgcataaa acttcacaca tatgcaagca

8401 cacacactgt ggcacataaa acttgtgaaa tctgaacaag gtgagtgcat tgtattaatg

8461 tcaattttct gattgtaata ctgtactgtg gttatggaag acattaccac tgggagaagc

8521 ttgttgaagg gtacacagga tctctctgta tttactctta cagtttcata tgaattttaa

8581 attatctcaa aataaaaaaa gaattaaaaa caatttaatg ttttcagtag gttgttctca

8641 taatatttaa agcagggcat agtttttaat attgtctaat tttgtttcct ttcagtctat

8701 gcatattgat gctactttat atacggaaag tgatgttcac gtgagtatac tttttttcaa

8761 aattgctatt tgtcttgtta ttaaagtttt taaaagtata tttttgtaac aactaaaata

8821 tggtagtttt aaaatctaac ttttggtgtg tttctataat atatggtcca tgagttttat

8881 tagtgattat tgagatggga cttggggaca gatagctaca tcaatgctat ttttgtaatg

8941 gtgccaaatc aaaatattaa aagagtcttt tccatcaatg tcaaacaaga tacattatac

9001 gtttttgtga tgcagttgca tcatggtgca attagatgca aaaatcagat taactgtttc

9061 aatttaagag tagccaatat atcagttatt tccaatgctg taatgtatca ccatctgcaa

9121 tcatattttc cataaattgc ttaaaatcat tcatgttctg cattttacat gattctctac 9181 atttgtcaga aaaagattct aattattctc tatgtgagaa aggaaacata acccatgaaa 9241 cttattagaa ctgaaaaatg gtcttgaact tgtttcatta ataccctgac atttcctaag 9301 gaatgtagga tttgtcatgt tggtggtggt tcttcccttc agtattgtta ctaaaaccaa 9361 gaaatgaatc cccaacttca cgtcagggaa aacaaactct atgtcctctc tccattattc 9421 ctcaattaga acttctctta catagatgac tttctaagca ttggaaagaa accatagtca 9481 gaaactagaa aaaagagata ttcactaacc aattgggtca tgctgctgca caaagaaatt 9541 gtctccctcc tctggcttca gcatggattc tgtttttctt tgcatttttt gtaaaatgga 9601 aagtagtcaa ttagccacca aattcagcat cctgaaattg cttttttgca agaagataac 9661 tttgcaaccc atgggttaga gaaacaacct tagattttag attttagatt ttagaagttt 9721 agattttaaa actgactcca ccacttttta cttgtgttac cttggagatt gctaaacatt 9781 tctgaagctc atttttatta ttgctgatat ggtgacagta tttgtctttc aatcctaagc 9841 agtgactgtt gggtttaagg aatattacca gtgctgggca catgggtgta ttccttcatt 9901 ttttttatcc attcagtaag catttgtgaa gtgtctgcag gctcccaggt actgtgcaag 9961 gtatcgagga cacaaagtca aataatggtc aaatccctag atattccttg tttcctttct 10021 ttaagttatt gttaaagtaa atgttgtgga aaacatattt ttgtggcacc taagagagcc 10081 ttttctgatt tgatctgcct gtaagtggac actagtcctg ctttgatttt tctaataaat 10141 ttcttggaat tacttctctc cctctggaac tttggaactt gaaagaacag tataattagc 10201 agctaccact atttaaaatg ttaacaacac aatttgattc taaaaattct tacaaataaa 10261 ctgtctatat tgatgttttc agactctaag gccagtatta ttaccctttc cacaggggaa 10321 atgtgctcgg tgagaaaaac tggccactat ttctgcattt tctagtttca tgttcttctg 10381 tacaatattg ccatccttct tgattgtgtt ttgttggttt gttttggttt ttattttaaa 10441 gccaaaagaa aaaaaattaa gctgcctcct atgtaaaatt tcttaaggat attgtgtatc 10501 tttataaaat atttggattg actttttgaa aatcaaaatt acatcagtat gaaaattaat 10561 aatcagaaaa aagtaattgt tctttataac ttttattttt agcccagttg caaagtaaca 10621 gcaatgaagt gctttctctt ggagttacaa gttatttcac ttgagtccgg agatgcaagt 10681 attcatgata cagtagaaaa tctgatcatc ctagcaaaca acagtttgtc ttctaatggg 10741 gtgagttttc caacagttgc ttagagttgc atcttatgtt ttgggcctga tttggagaag 10801 tcattcatgg acaagcagat cctcctaagg ggcaatcagg agaaggagtc ctgttccagt 10861 ggagtggtgt gcaaaagtgg caccatctcc agcatgcaca caatgctaaa ctgttcaatg 10921 attgattcag tagacaaaca tttacagaat aatgccaggt agtgtgcttc agtgctagaa 10981 ttatagttgc aaaccagaca gacaggtcac tgacctcaag gtgtttattg tcaggtgcag 11041 tggatagaca ttaatctaat tacatactca aatgtctaac atcaataata gtaactcaca 11101 tttattgagt tattactgta tgccagacac tattctttga gctttaaatt gataattcat 11161 ttaatcctca tgataaatct gtgagatagt tatctttatt tctgtttgaa tgttgaagaa 11221 attgtagcac tgagagcctg gatcactcgc ttcagttcat acagctagta aaatggggag 11281 ccacaactct tacccgagca gtctgtctgc agagtctgtt atctcatgag aagataaatg 11341 ctttaaaaag ataacaatga aaatattaat gattcgagta taatctggga catcccaggc 11401 aacttgagca gtagagggtt ccaggagagc aaattctagg tactcgtatg ataggctggg 11461 gaatcagctg tgcaatggcc ctgaagtgca aagaattagg gctttcatgg caaaacacca 11521 gtggccaaag caaggtagag agaaagcagt tttgcaacaa agaggcataa tcaaattagt 11581 tcatttcata aatacttttt agccctcagg agacagtatg aaaaaatacc cataatccct 11641 gctgttaaag agggaggaaa cagaaataaa ccaagcactc agcaaatgag taataagtta 11701 gttatttatg aagtccagtg gtgaaaaagg acacagggta ggggcactgg ggctccagtt 11761 agggtaggct gagctaataa gctgccattt gacaaagatg tgagagaatg agccttaagg 11821 gtatctaggg acatatgttt aggcagagac aactgaaagt gcaaaggccc taagcttgtg 11881 tgggtggaca ccttgacttt tctctaaaaa tacaagactg ctttaggtct ttgcttcagt 11941 gtcaccttct cagtgattta cctatttaca gttgcaatcc cttccctatc tgagcactcc 12001 ctgtcccctt ctctgcgtgt cccatatctg gaatatgata tattttatgt aatgggtatt 12061 gtctgttttt ccctactaga atgtcagctt aaaatggaca agtgtttttg ttttttatta 12121 gtactatatc caaattccca gaacagtgtc tcatatatat taaatacttt acatatgtat 12181 gaaatgaatt tattaaggtt tataatactc ttatgatgtt atctccatct tattggtgga 12241 aagagtgagc cacgcaacag gtaactcatg gcaaaataaa tgatgagctc tttaatgtga 12301 atgttgatag tcatcctcat catgacagag tgtgacatac gtgctggaat gcgtgggcag 12361 gactgcacag tcagaagacc tggatgggaa gaatttcagt tgattatgtc agttgagatg 12421 agtcaatatc tctgtcttcc tatctgacat gattattttc aggatcaaat aggacagcat 12481 tatatgaaat atgacagtgc ttggcataga ggatgtgctt gataaatgtc gctgattctg 12541 aattccaaat agttaatgga tataaaatct aatttttatt tttgctggca cagccttcat 12601 ggttcagatg atctctaaaa agtttattct taattgctac atttggaaca ttctagttat 12661 ccatgagact gtgtttgaag tacaacaatt tgtggtattc acctaaatgg ctcagttcaa 12721 ccaatgggtg attacagtgt gtcaggccct gtgctaaatg ctagggaaac aaacatactg 12781 gctctgacct tctggcagag agcttagaga atagtattac agtataaaaa gagtaaaact 12841 tcataatatg aatagaatac atgacatatt gtgagagagg tctaaataag gggttctgag 12901 atgtaaagat gggacattga gtccagccct aggagcccag gggttcagag aagcctccct 12961 aaaagagtac ctgaataatc ttaagtgcga gtagcagcag ctaaaatagg aatgaatgta 13021 acagagagaa aagcaaaggc agagaggcat ctaatagtat gctgtgcatg gcaaggaaag 13081 ccagatgctc actcagtgtt tctagggcat aacattgagg caagggggat atgtgaaata 13141 aataggtaag gaacagctca tgaagagcct gtgtgctatg cagggaggca tggtctttat 13201 gctagaagca gatgatagga aaccattgaa gggctcaaag caggaactcc gtggtctgat 13261 agacacagct tatttttctc aatgtcctta acccattatt ggaaaaataa acatatatca 13321 aatctccctg ttctctttcc tcgtagttct tcctaatatg ctatttattt gctaaagctt 13381 tcatatctca agacctcacc atatggttca aacgatatga tattcccatt cccatgaatg 13441 tatatttaat ttaattataa attgccaatt taatctctct ctatattttg cagaatgtaa 13501 cagaatctgg atgcaaagaa tgtgaggaac tggaggaaaa aaatattaaa gaatttttgc 13561 agagttttgt acatattgtc caaatgttca tcaacacttc ttgattgcaa ttgattcttt 13621 ttaaagtgtt tctgttatta acaaacatca ctctgctgct tagacataac aaaacactcg 13681 gcatttcaaa tgtgctgtca aaacaagttt ttctgtcaag aagatgatca gaccttggat 13741 cagatgaact cttagaaatg aaggcagaaa aatgtcattg agtaatatag tgactatgaa 13801 cttctctcag acttacttta ctcatttttt taatttatta ttgaaattgt acatatttgt 13861 ggaataatgt aaaatgttga ataaaaatat gtacaagtgt tgttttttaa gttgcactga 13921 tattttacct cttattgcaa aatagcattt gtttaagggt gatagtcaaa ttatgtattg 13981 gtggggctgg gtaccaatgc tgcaggtcaa cagctatgct ggtaggctcc tgccagtgtg 14041 gaaccactga ctactggctc tcattgactt ccttactaag catagcaaac agaggaagaa 14101 tttgttatca gtaagaaaaa gaagaactat atgtgaatcc tcttctttat actgtaattt 14161 agttattgat gtataaagca actgttatga aataaagaaa ttgcaataac tggcatataa 14221 tgtccatcag taaatcttgg tggtggtggc aataataaac ttctactgat aggtagaatg 14281 gtgtgcaagc ttgtccaatc acggattgca ggccacatgc ggcccaggac aactttgaat 14341 gtggcccaac acaaattcat aaactttcat acatctcgtt tttagctcat cagctatcat 14401 tagcggtagt gtatttaaag tgtggcccaa gacaattctt cttattccaa tgtggcccag 14461 ggaaatcaaa agattggatg cccctggtat agaaaactaa tagtgacagt gttcatattt 14521 catgctttcc caaatacagg tattttattt tcacattctt tttgccatgt ttatataata 14581 ataaagaaaa accctgttga tttgttggag ccattgttat ctgacagaaa ataattgttt 14641 atattttttg cactacactg tctaaaatta gcaagctctc ttctaatgga actgtaagaa 14701 agatgaaata tttttgtttt attataaatt tatttcacct taattctggt aatactcact 14761 gagtgactgt ggggtgggaa atgatctctt aagaatttga tttctttcta ttccatagta 14821 caaactcgtt ctctgttgaa acattcttct atcaccccag tgccctatcc atgtacatgt 14881 gttcttattg ctctagtcaa acggtgctta taaatatctt tcagaaagct taggagaaat 14941 ctαtatccta tttgacttcc aataatca

(2) INFORMATION FOR SEQ ID NO: 96: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 486 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 96: 1 cggattggga tcggacctac ttgattcact tctgggaaat caaggatcta cgtaccatgg

61 attttcaggt gcagattttc agcttcctgc taatcagtgc ctcagtcata atgtctagag 121 ccaactgggt gaatgtaata agtgatttga aaaaaattga agatcttatt caatctatgc 181 atattgatgc tactttatat acggaaagtg atgttcaccc cagttgcaaa gtaacagcaa 241 tgaagtgctt tctcttggag ttacaagtta tttcacttga gtccggagat gcaagtattc 301 atgatacagt agaaaatctg atcatcctag caaacaacag tttgtcttct aatgggaatg 361 taacagaatc tggatgcaaa gaatgtgagg aactggagga aaaaaatatt aaagaatttt 421 tgcagagttt tgtacatatt gtccaaatgt tcatcaacac ttcttgattg caattgattc 481 ctcgag

(2) INFORMATION FOR SEQ ID NO: 97: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17864 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 97: i aaatcctggc tgtcatgtac ttgctatggg cctagagtag cttacctaaa tgctactaac

61 cttcctccat accattattg taaagattaa aggtgatgca tctgttaagt aactaataga

121 gtgcttatta aaaggtaggt gttcaataag tattaattcc ctccctttct ttttcttact

181 agtgcacttg tgtttttaat ggatcatact ttaccctaga ttgtattgta ggaggcatcg

241 tggatggatg gctgctggaa accccttgcc atagccagct cttcttcaat acttaaggat

301 ttaccgtggc tttgagtaat gagaatttcg aaaccacatt tgagaagtat ttccatccag

361 tgctacttgt gtttacttct aaacagtcat tttctaactg aagctggcat tcatgtcttc

421 attttgggat gcagctaata tacccagttg gcccaaagca cctaacctat agttatataa

481 tctgactctc agttcagttt tactctacta atgccttcat ggtattggga accatagatt

541 tgtgcagctg tttcagtgca gggcttccta aaacagaagc caactgggtg aatgtaataa

601 gtgatttgaa aaaaattgaa gatcttattc aatctatgca tattgatgct actttatata

661 cggaaagtga tgttcacccc agttgcaaag taacagcaat gaagtgcttt ctcttggagt

721 tacaagttat ttcacttgag tccggagatg caagtattca tgatacagta gaaaatctga

781 tcatcctagc aaacaacagt ttgtcttcta atgggaatgt aacagaatct ggatgcaaag

841 aatgtgagga actggagaaa aaaaatatta aagaattttt gcagagtttt gtacatattg

901 tccaaatgtt catcaacact tcttgattgc aattgattct ttttaaagtg tttctgttat

961 taacaaacat cactctgctg cttagacata acaaaacact cggcatttca aatgtgctgt

1021 caaaacaagt ttttctgtca agaagatgat cagaccttgg atcagatgaa ctcttagaaa

1081 tgaaggcaga aaaatgtcat tgagtaatat agtgactatg aacttctctc agacttactt

1141 tactcatttt tttaatttat tattgaaatt gtacatattt gtggaataat gtaaaatgtt

1201 gaataaaaat atgtacaagt gttgtttttt aaaaaaaaaa aaaaaaaa 1 tgtccggcgc cccccgggag ggaactgggt ggccgcaccc tcccggctgc ggtggctgtc

61 gccccccacc ctgcagccag gactcgatgg agaatccatt ccaatatatg gccatgtggc

121 tctttggagc aatgttccat catgttccat gctgctgctg acgtcacatg gagcacagaa

181 atcaatgtta gcagatagcc agcccataca agatcgtatt gtattgtagg aggcatcgtg

241 gatggatggc tgctggaaac cccttgccat agccagctct tcttcaatac ttaaggattt

301 accgtggctt tgagtaatga gaatttcgaa accacatttg agaagtattt ccatccagtg

361 ctacttgtgt ttacttctaa acagtcattt tctaactgaa gctggcattc atgtcttcat 421 tttgggctgt ttcagtgcag ggcttcctaa aacagaagcc aactgggtga atgtaataag

481 tgatttgaaa aaaattgaag atcttattca atctatgcat attgatgcta ctttatatac

541 ggaaagtgat gttcacccca gttgcaaagt aacagcaatg aagtgctttc tcttggagtt

601 acaagttatt tcacttgagt ccggagatgc aagtattcat gatacagtag aaaatctgat

661 catcctagca aacaacagtt tgtcttctaa tgggaatgta acagaatctg gatgcaaaga

721 atgtgaggaa ctggaggaaa aaaatattaa agaatttttg cagagttttg tacatattgt

781 ccaaatgttc atcaacactt cttgattgca attgattctt tttaaagtgt ttctgttatt

841 aacaaacatc actctgctgc ttagacataa caaaacactc ggcatttaaa atgtgctgtc

901 aaaacaagtt tttctgtcaa gaagatgatc agaccttgga tcagatgaac tcttagaaat

961 gaaggcagaa aaatgtcatt gagtaatata gtgactatga acttctctca gacttacttt

1021 actcattttt ttaatttatt attgaaattg tacatatttg tggaataatg taaaatgttg

1081 aataaaaata tgtacaagtg ttgtttttta agttgcactg atattttacc tcttattgca

1141 aaatagcatt tgtttaaggg tgatagtcaa attatgtatt ggtggggctg ggtaccaatg

1201 ct ggcattgtaa tcagacagaa ctggcctcaa atcctggctg tcatgtactt gctatgggcc

61 tagagtagct tacctaaatg ctactaacct tcctccatac cattattgta aagattaaag

121 gtgatgcatc tgttaagtaa ctaatagagt gcttattaaa aggtaggtgt tcaataagta

181 ttaattccct ttctttcttt ttcttactag tgcacttgtg tttttaatgg atcatacttt

241 accctagatt gtattgtagg aggcatcgtg gatggatggc tgctggaaac cccttgccat

301 agccagctct tcttcaatac ttaaggattt accgtggctt tgagtaatga gaatttccgg

361 taagaagaaa aatagatgaa aatatcctat ggaatttccc ttaaaggtcg tctgaatctc

421 agagtctttg caataagtta catggttatt ctccaaagat cttgagatat cacagatgtc

481 tgttcacatt tggattgttc ttattttgaa aataaatagg tttttaaaaa ctctattgac

541 catcttgata ggctcttctt gtcattataa atgtgttatt tcacttatcc cactcttttg

601 tgttctctaa atgtctttgt actcactaaa ttgtgtagtc ttagagggca gggtgtgggt

661 atcattcatc tttttgaaag gaagcatgaa caattagtgg ttaaggtggc agttaacact

721 gctttctgaa actttaaaag cttcgacaac acaaaagagg caggtgaaag taccaaaact

781 ctggtaagtt gtaggataaa tgattttcct aaatcaccaa gaaagattat tagtcactct

841 caagatggaa tacagtatct gtaattggtt ccattttatc caatttttca ccaaataata

901 ttaatataat tcattttcat aatttacatg aagttaatat aactattgca tctctgttag

961 taatgcatgt tattaacctg tgctgtataa aatattttga cctattaaaa aagaaagaag

1021 gatgaggagg aggtcaaaga taatataaaa actttaagtg gtgacattgg tatgtatgta

1081 aattaacaaa tatgtcaact ttgttaaatt atctttgaca tgcatctgca gaaatatctg

1141 ttaaggaact ttgtgcataa gagacagagt tggaggtggg agagaaagtg aaaaaagata

1201 aattatagtt ttattatttt tgataagggg cagtaattat gaaattatga caaacttaca

1261 tctttagacc tagaaatatg ttgacatgtt attttaaacc tcacttttta actaaaaaat

1321 ttaaccattt gtctatgatt atatttttca gaaaccacat ttgagaagta tttccatcca

1381 gtgctacttg tgtttacttc taaacagtca ttttctaact gaagctggca ttcatgtctt

1441 cattttgggg gtaattttat ctttaggcat aaataacatt atgttcatgg tcatgatgat

1501 tgtccttgga tatattttcc attaaattag tttacgttca gtttgcttat atctctaggt

1561 actcagtatc tgggggatag aaggcagact acagagattt agagaggttt ggtaaacacc

1621 taactgagca tttttctaca ttgtggtaat agtccaaaca agcattatag ccctcaaata

1681 aattgggcct tttgatattt aactgaactt ggaagtatac cacttattga tagactacat

1741 atttttcatg gcaattaaaa gtagatattt agaatttgct tatgttactt ttttatctgt

1801 ccctgacact gactcctcct atcccttgat ctttatccta gttcagttta aaacatttct

1861 ttctttattt aagccttttg ttgtttcctt ctaataaaat tcatatgttt ccatgactat

1921 taactttttt cttctctctt agatgcagct aatataccca gttggcccaa agcacctaac

1981 ctatagttat ataatctgac tctcagttca gttttactct actaatgcct tcatggtatt

2041 gggaaccata gatttgtgca ggtaattctt catcataaga cagattagtg ttgactatca

2101 tgcttctgtg taagatccat caggaagtga gtgattattt ttcctcaagc tctaagcatc

2161 attccaatgt tacttggtca gtataagtgt attttgtctg gatattaaat tttaattttt

2221 atgaaatttg tgaaagtgag taagtatatg atcattcagc ctacactgga atgaagtctg

2281 tactgtttat ggagaaagct gctgcaagca tagtaagagt gtgagcaaca tgaaaggggc

2341 atgtttaatg tagtgtaaaa aaaatttact atcaaaatca ttacatgaaa atgattatta

2401 ctcattttaa gaattttacc tatttattag acttcaaagt ctctgtaaat ctctacttaa

2461 aggaaactag taattcattc aaaatcattt attgagcatt gccacacatc tggcactgct

2521 tctatttcat tgtgataaat tgagccagtt tatttataaa gtatgcctac agttaggctt

2581 ttctctaatc cgggttggtg aagcctcaag ttatcataaa atgccaaaat tgtactatat

2641 gctcaatgtt tatgttcagt tacaaggctg ttgaatgcac agaagcaagg ataacactga

2701 ttttttcact ggtcagaata aaaattattg attgctcttt tgcttatagt attcatcaag

2761 atgaataggc tccttcaaaa tgctttgctc tatggttttt ctttcagctg tttcagtgca

2821 gggcttccta aaacagaagc caactgggtg aatgtaataa gtgatttgaa aaaaattgaa

2881 gatcttattc aagtgagtac tcatttttcc ataaaatgcc tggtataact gctatggagt

2941 ttgtctctct ctgtgttttt ctgtctgtct taaggaaacc acacttgaaa caataatatt

3001 tttgtagaaa tttatgatct tataaagctc aaaaagaagt cttttcctta ctgttttaga

3061 atctaattat ctttaaaacg taatttataa gcggcccaga cggatgagtt ctagtctgca

3121 caggtgaggt attctcttcc tctatctgga gaagccagat atcttggtgg cacctgcagg

3181 gagaatggct tgacccaggg aacagctgtt gttgcttgtg gactaaaggc cctcttctcc

3241 cacctcaaga aaacaggtgg cctgacctaa ggaagtgatt tttgccatag caggtaatac

3301 cagcttcagt ggaagtctcg atggcaccaa gcataccaaa atagcaccac aaagttctga

3361 aaactaaatt gtcattggaa tcacagcatt aaaaaatagg ttagaacttg catgctaaat

3421 ccaaacaacc tgactgcatg ttaaaataga agatttaaat aggaccagag tgtcctaaca

3481 taatagacat gaagccaaga tacaattgga aatcacccat tgtaacaaga aataggaaag

3541 ttacaactta aatgagaaaa tatagtcaac agattacaaa attgaagtgg atcagatgtt

3601 ggaattctct gacatagatt tgaaagcaga cattataaaa agtgcttgaa aaagcaatta 3661 caaatgccct tgaagcaaat gaaaaactaa atgccttaac aaagaaatag aagatatgaa 3721 aggaaccata tagaaattat ataactgaaa atataactga aatataaagc aaactgtaaa 3781 ggctcattag cagaatgaat gacagaggaa tgatagttaa tttgacaaca gaatactaga 3841 gagacagttg acttaagaaa aaaaaagcat cactgatctt gacgacagta acaaaagatt 3901 cagcattcct atggttagta tcacaggaga gtatgagaat acaccaagta aaagagagag 3961 attggttgaa ttcataacaa aacaccaccc atctatacta tctataagca gttcacttct 4021 agtacaatga catacatagg ttgaaattta aaaagacaga aaaagatata gcatactata 4081 atgggttgaa tagtgtcccc ccaaatttca catcctcttg gaaccttaaa atgtgatctt 4141 attttgaaat aatatctttg caaatataat taatgaaatt aagatgagat catactagag 4201 tagggggggc cctaaatcca atgacaagtg tctttattag aaaaggaaag gacacagagt 4261 aactcactgg gaagaaagcc atgtgaagac agaggaagag atcagagtga tgcggctata 4321 agccaaggaa ggccagagat tgccaggatc caccagaacc ttggggaagt caagaaagca 4381 ttcttctcta gactgataca catgcataca ttaattataa aaagcagaag tggctatatt 4441 aacatcaaag ttaatgttat taacataaag tagacttcac agaaaataaa gttgctataa 4501 tccagaggga tattacaaaa tgataaaaaa taaatctgtg aggaaaacat aatgttctta 4561 aatgtataca catcaaacaa cgaagactca aaatttgtga aacaaaaaat aatagggata 4621 aaagagaaat agacaaatcc acaattattc ttgaggactt cactgcctcc tcctcagtaa 4681 ctaatggaag tactagacag aaaatcagaa agggcataaa aatacaatat aaccaaccaa 4741 caggatctaa tttaatacat agagcactac acccaacaac agcagaatat actttctttt 4801 atcaagacta aatatatact gagccataaa agaaacttta aaaatttttt cagaacttaa 4861 atcatgcaga atttgttctc aaaccacaat ggaatcaaac cagaaatcaa gaaattaaat 4921 acaacgggca aatctccaaa tgcttggaaa ttaaatacta tacctctata taatccatgg 4981 gtcaaagagt aaatctcaaa ggatattcat aatacataga atgaaaaaaa atgaaataca 5041 gcatatcaag atatatgtga tgtggctaaa gcaatactga caggacattt tttaaaatca 5101 aatgaataca ttagaaaaaa aggagaatta tcaaatcaaa aatctaagtt actgcttcaa 5161 gaaactagaa gaagtagagc aaaacaaatt caatacaagc agaacaaaga aaatatttaa 5221 atataagagc caaaattaat gaagttgaaa tcaagaaaac aatagaaaaa attaatgaaa 5281 cataaaactg gttatttgga aaatcaatac aattgatctt taattgacag aaataagaga 5341 gaagacacaa atctcaggaa tgaaatttgg ggctgtcact acagaatctg cagtcattag 5401 aaggataata agaaaaacta tgaacaattt tatgctcaca aatctgataa cttagaggaa 5461 atggaccaat tcttcagaaa ccacaaacta ccaaaacata atgaagatga aatagacaat 5521 ccaaacactc atataatcac taaatacatt gaattcatca tacacaagct cccaaaaagg 5581 gaccttcaag cctgctggtt acactgaatc attctatcaa atatttacag aagcattaac 5641 aacaattgta cagtctcttc tagaaaatag aagaggaagg aacattttcc agttgatttt 5701 aggaggccag tattactgtg atgctaaaac caaataaaga tattactaaa aaagacaact 5761 acaaaaatat ctcccattaa cttagatatt aaaatgctct ataaaatatt aacaaatcga 5821 attcagcaat gtataaaaag aattatacac catgaccgag tgagatttat ttcaggtaca 5881 caagtcttgc tcaattattt gaaagtcaag caatgtaatc taccctatca acaggctaaa 5941 gaagaaaatc atatgtagaa aaggtatctg ataaaatgca acacctctca tggcctgtgt 6001 ccctccctat gcctcctgga tttatatgtt gaagtactaa ttgccagtat atcaaaatgt 6061 gactgtattt tgagataggg tcagttaaaa tgaggtcatg agggcaggtc ctactgcaat 6121 atgactggta tctttagaaa aacagataag ggtatagata cacagagata gaaaaccatg 6181 tgaagacact gggagaaaat ggccacctat aagccaagga gggaggactc caaagaaacc 6241 aacactgctg gtaccctgat ttcagacctc tagcctcctg aattgtgaga aaataaagtt 6301 ctattattta agtcaccaag tctgtggtac tttttatagc agccctagca gactgatata 6361 aacacctatt gaagataaaa tttcttagaa agtaggtgtg gagaactgcc tcaacttggt 6421 acaaaacatg ttcaaaaagt ctagagctac catacttaat ggtgagtaca agactgaatg 6481 tttttctgct aggactggaa actaagcagg gatatcttct ctcaccactt ttactcaaca 6541 taattgtctg agttttctgt tgcttataac agagtacttg aaatgcataa tttataaaga 6601 aaggaattta tgtcttatgg ttatgagact gaaaagttca aggttgagga gccacatctg 6661 gtgagggcct tcctgctggt gggggctctc tggagtccag aggtgacaaa aagcatcaca 6721 tggcgagggg ctgaatgtac tcatgtgcta gctcaggtct ctcttcctct tcttataaaa 6781 ctaccggttc cctttccgta ataacacatt gatactctaa tccattcatg agggcagagc 6841 cattgtgatc caattacctc ttaaagcccc acctctcaat actgccacat tggggattaa 6901 gtttcaatct gaattttgga ggggacattc aaaccacagc aataatattg gaagtttagc 6961 caaattatga agcaggagag aaaaaatgta tgagaaaaaa ataaataaaa ggcacacaga 7021 ttggaaagga aaattataca tcaccccaag ttttttggag agaaagtagt aaaaatgggt 7081 atattttgtt tagaaagtaa tgcaaattaa aaccacaatg acatattatt acatgcagct 7141 ataagcgtat acagaataaa aaatagtgat gatgctaagt aaatataaat gaacaagggt 7201 gataatgctg gcaaggatgt ggagaaactg gatcattcat acattgctgg tgatgatgta 7261 aaatgataca ggcactgtat aaaatagttt ggcagcatcc tatgaaacaa aacatgcatt 7321 tgccttacaa tccaacaatt gtgctcttag acattcatcc ttgataaatg aaaactacgt 7381 gcacacaaaa atatgtacat gaatgttcac agagattttt tcatgactgc caaaaactgg 7441 aaacagatgt gcttcagttg gtaaaatctg tgatatatca tgtcagggaa tactacagag 7501 caataaaaag gaacaaacta gtgataccca caagttaggt ggatctccag ggtattatga 7561 tgagtgaaaa aagccagtct tcataaagaa actgtggtac atttataaaa tagaatatta 7621 tccagtgata aaaagaaata agctatcaag ccatgaaaag aaatggagaa accttcaaag 7681 tcatattgtt gagtgaaaga tggggacgcc aatctgaaaa ggcttcacac tgtatgatcc 7741 caactatgac attttgaaaa aggcaaagct atggagacaa taaaaagatc agtggttgtt 7801 aggggtttgg agggaaggag aaatggctag gcagagcaca ggctactttt aaagcagtga 7861 aaatattaat atatgatgat gggtggcatt atacatttgt caaaacctgt aaaacataca 7921 acacaaataa tgagccctaa tattctgtac acttaagatc ataatagtga ttcaccaact 7981 ataacaaaca caccacacta atgcaagata ttaacaatag ggaaactggg gtggagaaca 8041 aaggggtgta taagtctctg tactttctgc tagtttttct gtaaacctaa atggctcata 8101 aaaatgtcta tcaattcttt taaaagctaa tttcagaagg ttacatatga tatgagtccg 8161 tttacataat attcttgaaa tgacaaaatt ataggcatgg agagcagaga agtggttgcc

8221 agaatttaga gagattgggt gatgatgagg tatgtatggg gagaaaggtg actttggtta

8281 tgaaagaata gcagcagaat ccttgtggtg atgaaactat tttgtgtctt aactgtggtg

8341 gtggtgatgt gaatctatgc aaatgataaa attgcataaa acttcacaca tatgcaagca

8401 cacacactgt ggcacataaa acttgtgaaa tctgaacaag gtgagtgcat tgtattaatg

8461 tcaattttct gattgtaata ctgtactgtg gttatggaag acattaccac tgggagaagc

8521 ttgttgaagg gtacacagga tctctctgta tttactctta cagtttcata tgaattttaa

8581 attatctcaa aataaaaaaa gaattaaaaa caatttaatg ttttcagtag gttgttctca

8641 taatatttaa agcagggcat agtttttaat attgtctaat tttgtttcct ttcagtctat

8701 gcatattgat gctactttat atacggaaag tgatgttcac gtgagtatac tttttttcaa

8761 aattgctatt tgtcttgtta ttaaagtttt taaaagtata tttttgtaac aactaaaata

8821 tggtagtttt aaaatctaac ttttggtgtg tttctataat atatggtcca tgagttttat

8881 tagtgattat tgagatggga cttggggaca gatagctaca tcaatgctat ttttgtaatg

8941 gtgccaaatc aaaatattaa aagagtcttt tccatcaatg tcaaacaaga tacattatac

9001 gtttttgtga tgcagttgca tcatggtgca attagatgca aaaatcagat taactgtttc

9061 aatttaagag tagccaatat atcagttatt tccaatgctg taatgtatca ccatctgcaa

9121 tcatattttc cataaattgc ttaaaatcat tcatgttctg cattttacat gattctctac

9181 atttgtcaga aaaagattct aattattctc tatgtgagaa aggaaacata acccatgaaa

9241 cttattagaa ctgaaaaatg gtcttgaact tgtttcatta ataccctgac atttcctaag

9301 gaatgtagga tttgtcatgt tggtggtggt tcttcccttc agtattgtta ctaaaaccaa

9361 gaaatgaatc cccaacttca cgtcagggaa aacaaactct atgtcctctc tccattattc

9421 ctcaattaga acttctctta catagatgac tttctaagca ttggaaagaa accatagtca

9481 gaaactagaa aaaagagata ttcactaacc aattgggtca tgctgctgca caaagaaatt

9541 gtctccctcc tctggcttca gcatggattc tgtttttctt tgcatttttt gtaaaatgga

9601 aagtagtcaa ttagccacca aattcagcat cctgaaattg cttttttgca agaagataac

9661 tttgcaaccc atgggttaga gaaacaacct tagattttag attttagatt ttagaagttt

9721 agattttaaa actgactcca ccacttttta cttgtgttac cttggagatt gctaaacatt

9781 tctgaagctc atttttatta ttgctgatat ggtgacagta tttgtctttc aatcctaagc

9841 agtgactgtt gggtttaagg aatattacca gtgctgggca catgggtgta ttccttcatt

9901 ttttttatcc attcagtaag catttgtgaa gtgtctgcag gctcccaggt actgtgcaag

9961 gtatcgagga cacaaagtca aataatggtc aaatccctag atattccttg tttcctttct

10021 ttaagttatt gttaaagtaa atgttgtgga aaacatattt ttgtggcacc taagagagcc

10081 ttttctgatt tgatctgcct gtaagtggac actagtcctg ctttgatttt tctaataaat

10141 ttcttggaat tacttctctc cctctggaac tttggaactt gaaagaacag tataattagc

10201 agctaccact atttaaaatg ttaacaacac aatttgattc taaaaattct tacaaataaa

10261 ctgtctatat tgatgttttc agactctaag gccagtatta ttaccctttc cacaggggaa

10321 atgtgctcgg tgagaaaaac tggccactat ttctgcattt tctagtttca tgttcttctg

10381 tacaatattg ccatccttct tgattgtgtt ttgttggttt gttttggttt ttattttaaa

10441 gccaaaagaa aaaaaattaa gctgcctcct atgtaaaatt tcttaaggat attgtgtatc

10501 tttataaaat atttggattg actttttgaa aatcaaaatt acatcagtat gaaaattaat

10561 aatcagaaaa aagtaattgt tctttataac ttttattttt agcccagttg caaagtaaca

10621 gcaatgaagt gctttctctt ggagttacaa gttatttcac ttgagtccgg agatgcaagt

10681 attcatgata cagtagaaaa tctgatcatc ctagcaaaca acagtttgtc ttctaatggg

10741 gtgagttttc caacagttgc ttagagttgc atcttatgtt ttgggcctga tttggagaag

10801 tcattcatgg acaagcagat cctcctaagg ggcaatcagg agaaggagtc ctgttccagt

10861 ggagtggtgt gcaaaagtgg caccatctcc agcatgcaca caatgctaaa ctgttcaatg

10921 attgattcag tagacaaaca tttacagaat aatgccaggt agtgtgcttc agtgctagaa

10981 ttatagttgc aaaccagaca gacaggtcac tgacctcaag gtgtttattg tcaggtgcag

11041 tggatagaca ttaatctaat tacatactca aatgtctaac atcaataata gtaactcaca

11101 tttattgagt tattactgta tgccagacac tattctttga gctttaaatt gataattcat

11161 ttaatcctca tgataaatct gtgagatagt tatctttatt tctgtttgaa tgttgaagaa

11221 attgtagcac tgagagcctg gatcactcgc ttcagttcat acagctagta aaatggggag

11281 ccacaactct tacccgagca gtctgtctgc agagtctgtt atctcatgag aagataaatg

11341 ctttaaaaag ataacaatga aaatattaat gattcgagta taatctggga catcccaggc

11401 aacttgagca gtagagggtt ccaggagagc aaattctagg tactcgtatg ataggctggg

11461 gaatcagctg tgcaatggcc ctgaagtgca aagaattagg gctttcatgg caaaacacca

11521 gtggccaaag caaggtagag agaaagcagt tttgcaacaa agaggcataa tcaaattagt

11581 tcatttcata aatacttttt agccctcagg agacagtatg aaaaaatacc cataatccct

11641 gctgttaaag agggaggaaa cagaaataaa ccaagcactc agcaaatgag taataagtta

11701 gttatttatg aagtccagtg gtgaaaaagg acacagggta ggggcactgg ggctccagtt

11761 agggtaggct gagctaataa gctgccattt gacaaagatg tgagagaatg agccttaagg

11821 gtatctaggg acatatgttt aggcagagac aactgaaagt gcaaaggccc taagcttgtg

11881 tgggtggaca ccttgacttt tctctaaaaa tacaagactg ctttaggtct ttgcttcagt

11941 gtcaccttct cagtgattta cctatttaca gttgcaatcc cttccctatc tgagcactcc

12001 ctgtcccctt ctctgcgtgt cccatatctg gaatatgata tattttatgt aatgggtatt

12061 gtctgttttt ccctactaga atgtcagctt aaaatggaca agtgtttttg ttttttatta

12121 gtactatatc caaattccca gaacagtgtc tcatatatat taaatacttt acatatgtat

12181 gaaatgaatt tattaaggtt tataatactc ttatgatgtt atctccatct tattggtgga

12241 aagagtgagc cacgcaacag gtaactcatg gcaaaataaa tgatgagctc tttaatgtga

12301 atgttgatag tcatcctcat catgacagag tgtgacatac gtgctggaat gcgtgggcag

12361 gactgcacag tcagaagacc tggatgggaa gaatttcagt tgattatgtc agttgagatg

12421 agtcaatatc tctgtcttcc tatctgacat gattattttc aggatcaaat aggacagcat

12481 tatatgaaat atgacagtgc ttggcataga ggatgtgctt gataaatgtc gctgattctg

12541 aattccaaat agttaatgga tataaaatct aatttttatt tttgctggca cagccttcat

12601 ggttcagatg atctctaaaa agtttattct taattgctac atttggaaca ttctagttat 12661 ccatgagact gtgtttgaag tacaacaatt tgtggtattc acctaaatgg ctcagttcaa

12721 ccaatgggtg attacagtgt gtcaggccct gtgctaaatg ctagggaaac aaacatactg

12781 gctctgacct tctggcagag agcttagaga atagtattac agtataaaaa gagtaaaact

12841 tcataatatg aatagaatac atgacatatt gtgagagagg tctaaataag gggttctgag

12901 atgtaaagat gggacattga gtccagccct aggagcccag gggttcagag aagcctccct

12961 aaaagagtac ctgaataatc ttaagtgcga gtagcagcag ctaaaatagg aatgaatgta

13021 acagagagaa aagcaaaggc agagaggcat ctaatagtat gctgtgcatg gcaaggaaag

13081 ccagatgctc actcagtgtt tctagggcat aacattgagg caagggggat atgtgaaata

13141 aataggtaag gaacagctca tgaagagcct gtgtgctatg cagggaggca tggtctttat

13201 gctagaagca gatgatagga aaccattgaa gggctcaaag caggaactcc gtggtctgat

13261 agacacagct tatttttctc aatgtcctta acccattatt ggaaaaataa acatatatca

13321 aatctccctg ttctctttcc tcgtagttct tcctaatatg ctatttattt gctaaagctt

13381 tcatatctca agacctcacc atatggttca aacgatatga tattcccatt cccatgaatg

13441 tatatttaat ttaattataa attgccaatt taatctctct ctatattttg cagaatgtaa

13501 cagaatctgg atgcaaagaa tgtgaggaac tggaggaaaa aaatattaaa gaatttttgc

13561 agagttttgt acatattgtc caaatgttca tcaacacttc ttgattgcaa ttgattcttt

13621 ttaaagtgtt tctgttatta acaaacatca ctctgctgct tagacataac aaaacactcg

13681 gcatttcaaa tgtgctgtca aaacaagttt ttctgtcaag aagatgatca gaccttggat

13741 cagatgaact cttagaaatg aaggcagaaa aatgtcattg agtaatatag tgactatgaa

13801 cttctctcag acttacttta ctcatttttt taatttatta ttgaaattgt acatatttgt

13861 ggaataatgt aaaatgttga ataaaaatat gtacaagtgt tgttttttaa gttgcactga

13921 tattttacct cttattgcaa aatagcattt gtttaagggt gatagtcaaa ttatgtattg

13981 gtggggctgg gtaccaatgc tgcaggtcaa cagctatgct ggtaggctcc tgccagtgtg

14041 gaaccactga ctactggctc tcattgactt ccttactaag catagcaaac agaggaagaa

14101 tttgttatca gtaagaaaaa gaagaactat atgtgaatcc tcttctttat actgtaattt

14161 agttattgat gtataaagca actgttatga aataaagaaa ttgcaataac tggcatataa

14221 tgtccatcag taaatcttgg tggtggtggc aataataaac ttctactgat aggtagaatg

14281 gtgtgcaagc ttgtccaatc acggattgca ggccacatgc ggcccaggac aactttgaat

14341 gtggcccaac acaaattcat aaactttcat acatctcgtt tttagctcat cagctatcat

14401 tagcggtagt gtatttaaag tgtggcccaa gacaattctt cttattccaa tgtggcccag

14461 ggaaatcaaa agattggatg cccctggtat agaaaactaa tagtgacagt gttcatattt

14521 catgctttcc caaatacagg tattttattt tcacattctt tttgccatgt ttatataata

14581 ataaagaaaa accctgttga tttgttggag ccattgttat ctgacagaaa ataattgttt

14641 atattttttg cactacactg tctaaaatta gcaagctctc ttctaatgga actgtaagaa

14701 agatgaaata tttttgtttt attataaatt tatttcacct taattctggt aatactcact

14761 gagtgactgt ggggtgggaa atgatctctt aagaatttga tttctttcta ttccatagta

14821 caaactcgtt ctctgttgaa acattcttct atcaccccag tgccctatcc atgtacatgt

14881 gttcttattg ctctagtcaa acggtgctta taaatatctt tcagaaagct taggagaaat

14941 ctgtatccta tttgacttcc aataatca cggattggga tcggacctac ttgattcact tctgggaaat caaggateta cgtaccatgg

61 attttcaggt gcagattttc agcttcctgc taatcagtgc ctcagtcata atgtctagag

121 ccaactgggt gaatgtaata agtgatttga aaaaaattga agatcttatt caatctatgc

181 atattgatgc tactttatat acggaaagtg atgttcaccc cagttgcaaa gtaacagcaa

241 tgaagtgctt tctcttggag ttacaagtta tttcacttga gtccggagat gcaagtattc

301 atgatacagt agaaaatctg atcatcctag caaacaacag tttgtcttct aatgggaatg

361 taacagaatc tggatgcaaa gaatgtgagg aactggagga aaaaaatatt aaagaatttt

421 tgcagagttt tgtacatatt gtccaaatgt tcatcaacac ttcttgattg caattgattc

481 ctcgag

(2) INFORMATION FOR SEQ ID NO: 98: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1610 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 98: cccagagcag cgctcgccac ctccccccgg cctgggcagc gctcgcccgg ggagtccagc

61 ggtgtcctgt ggagctgccg ccatggcccc gcggcgggcg cgcggctgcc ggaccctcgg 121 tctcccggcg ctgctactgc tgctgctgct ccggccgccg gcgacgcggg gcatcacgtg 181 ccctcccccc atgtccgtgg aacacgcaga catctgggtc aagagctaca gcttgtactc 241 cagggagcgg tacatttgta actctggttt caagcgtaaa gccggcacgt ccagcctgac 301 ggagtgcgtg ttgaacaagg ccacgaatgt cgcccactgg acaaccccca gtctcaaatg 361 cattagagac cctgccctgg ttcaccaaag gccagcgcca ccctccacag taacgacggc 421 aggggtgacc ccacagccag agagcctctc cccttctgga aaagagcccg cagcttcatc 481 tcccagctca aacaacacag cggccacaac agcagctatt gtcccgggct cccagctgat 541 gccttcaaaa tcaccttcca caggaaccac agagataagc agtcatgagt cctcccacgg 601 caccccctct cagacaacag ccaagaactg ggaactcaca gcatccgcct cccaccagcc 661 gccaggtgtg tatccacagg gccacagcga caccactgtg gctatctcca cgtccactgt 721 cctgctgtgt gggctgagcg ctgtgtctct cctggcatgc tacctcaagt caaggcaaac 781 tcccccgctg gccagcgttg aaatggaagc catggaggct ctgccggtga cttgggggac 841 cagcagcaga gatgaagact tggaaaactg ctctcaccac ctatgaaact cggggaaacc 901 agcccagcta agtccggagt gaaggagcct ctctgcttta gctaaagacg actgagaaga 961 ggtgcaagga agcgggctcc aggagcaagc tcaccaggcc tctcagaagt cccagcagga 1021 tctcacggac tgccgggtcg gcgcctcctg cgcgagggag caggttctcc gcattcccat 1081 gggcaccacc tgcctgcctg tcgtgccttg gacccagggc ccagcttccc aggagagacc 1141 aaaggcttct gagcaggatt tttatttcat tacagtgtga gctgcctgga atacatgtgg

1201 taatgaaata aaaaccctgc cccgaatctt ccgtccctca tcctaacttg cagttcacag

1261 agaaaagtga catacccaaa gctctctgtc aattacaagg cttctcctgg cgtgggagac

1321 gtctacaggg aagacaccag cgtttgggct tctaaccacc ctgtctccag ctgctctgca

1381 cacatggaca gggacctggg aaaggtggga gagatgctga gcccagcgaa tcctctccat

1441 tgaaggattc aggaagaaga aaactcaact cagtgccatt ttacgaatat atgcgtttat

1501 atttatactt ccttgtctat tatatctata cattatatat tatttgtatt ttgacattgt

1561 accttgtata aacaaaataa aacatctatt ttcaatattt ttaaaatgca

(2) INFORMATION FOR SEQ ID NO: 99: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 393 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 99: atgcctgacc tcaactcctc cactgactct gcagcctcag cctctgcagc cagtgatgtt

61 tctgtagaat ctacagcaga ggccacagtc tgcacggtga cactggagaa gatgtcggca 121 gggctgggct tcagcctgga aggagggaag ggctccctac acggagacaa gcccctcacc 181 attaacagga ttttcaaagg agcagcctca gaacaaagtg agacagtcca gcctggagat 241 gaaatcttgc agctgggtgg cactgccatg cagggcctca cacggtttga agcctggaac 301 atcatcaagg cactgcctga tggacctgtc acgattgtca tcaggagaaa aagcctccag 361 tccaaggaaa ccacagctgc tggagactcc tag

(2) INFORMATION FOR SEQ ID NO: 100: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3175 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 100: tgcttaaaaa aacacaacag gattttcgaa gaatcctttc ttagaaaaca aacaaaaaaa

61 ccaaacaaaa acgtactttc tccccactag tttacaccac aggaagcgag agagctgctg

121 ccactgctgc taccacagga agacacagca gggagaagcc ctagtgcctc tgccggctgc

181 ccaggacctg gtatcggccc acagaccaag tcctccacag agggcgagcc agggtggaga

241 agagccagcc cagtgaccca aacatccccg ataaaacacc cactgcttaa gaggcaggct

301 cggatggact atagctttga taccacagcc gaagaccctt gggttaggat ttctgactgc

361 atcaaaaact tatttagccc catcatgagt gagaaccatg gccacatgcc tctacagccc

421 aatgccagcc tgaatgaaga agaagggaca cagggccacc cagatgggac cccaccaaag

481 ctggacaccg ccaatggcac tcccaaagtt tacaagtcag cagacagcag cactgtgaag

541 aaaggtcctc ctgtggctcc caagccagcc tggtttcgcc aaagcttgaa aggtttgagg

601 aatcgtgctt cagagccaag agggctccct gatcctgcct tgtccaccca gccagcacct

661 gcttccaggg agcacctagg atcacacatc cgggcctcct cctcctcctc ctccatcagg

721 cagagaatca gctcctttga aacctttggc tcctctcaac tgcctgacaa aggagcccag

781 agactgagcc tccagccctc ctctggggag gcagcaaaac ctcttgggaa gcatgaggaa

841 ggacggtttt ctggactctt ggggcgaggg gctgcaccca ctcttgtgcc ccagcagcct

901 gagcaagtac tgtcctcggg gtcccctgca gcctccgagg ccagagaccc aggtgtgtct

961 gagtcccctc ccccagggcg gcagcccaat cagaaaactt tcccccctgg cccggacccg

1021 ctcctaaggc tgctgtcaac acaggctgag gaatctcaag gcccagtgct caagatgcct

1081 agccagcgag cacggagctt ccccctgacc aggtcccagt cctgtgagac gaagctactt

1141 gacgaaaaga ccagcaaact ctattctatc agcagccaag tgtcatcggc tgtcatgaaa

1201 tccttgctgt gccttccatc ttctatctcc tgtgcccaga ctccctgcat ccccaaggca

1261 ggggcatctc caacatcatc atccaacgaa gactcagctg caaatggttc tgctgaaaca

1321 tctgccttgg acacggggtt ctcgctcaac ctttcagagc tgagagaata tacagagggt

1381 ctcacggaag ccaaggaaga cgatgatggg gaccacagtt cccttcagtc tggtcagtcc

1441 gttatctccc tgctgagctc agaagaatta aaaaaactca tcgaggaggt gaaggttctg

1501 gatgaagcaa cattaaagca attagacggc atccatgtca ccatcttaca caaggaggaa

1561 ggtgctggtc ttgggttcag cttggcagga ggagcagatc tagaaaacaa ggtgattacg

1621 gttcacagag tgtttccaaa tgggctggcc tcccaggaag ggactattca gaagggcaat

1681 gaggttcttt ccatcaacgg caagtctctc aaggggacca cgcaccatga tgccttggcc

1741 atcctccgcc aagctcgaga gcccaggcaa gctgtgattg tcacaaggaa gctgactcca

1801 gaggccatgc ccgacctcaa ctcctccact gactctgcag cctcagcctc tgcagccagt

1861 gatgtttctg tagaatctac agcagaggcc acagtctgca cggtgacact ggagaagatg

1921 tcggcagggc tgggcttcag cctggaagga gggaagggct ccctacacgg agacaagcct

1981 ctcaccatta acaggatttt caaaggagca gcctcagaac aaagtgagac agtccagcct

2041 ggagatgaaa tcttgcagct gggtggcact gccatgcagg gcctcacacg gtttgaagcc

2101 tggaacatca tcaaggcact gcctgatgga cctgtcacga ttgtcatcag gagaaaaagc

2161 ctccagtcca aggaaaccac agctgctgga gactcctagg caggacatgc tgaagccaaa

2221 gccaataaca cacagctaac acacagctcc cataaccgct gattctcagg gtctctgctg

2281 ccgccccacc cagatggggg aaagcacagg tgggcttccc agtggctgct gcccaggccc

2341 agaccttcta ggacgccacc cagcaaaagg ttgttcctaa aataagggca gagtcacact

2401 ggggcagctg atacaaattg cagactgtgt aaaaagagag cttaatgata atattgtggt

2461 gccacaaata aaatggattt attagaattc catatgacat tcatgcctgg cttcgcaaaa

2521 tgtttcaagt actgtaactg tgtcatgatt cacccccaaa cagtgacatt tatttttctc

2581 atgaatctgc aatgtgggca gagattggaa tgggcagctc atctctgtcc cacttggcat 2641 cagctggcgt catgcaaagt catgcaaagg ctgggaccac ctgagatcat tcactcatac

2701 atctggccgt tgatgttggc tgggaactca cctggggctg ctggcctgaa tgcttatagg

2761 tggcctctcc ttgtggcctg ggctcctcac aacatggtgt ctggattccc aggatgagca

2821 tcccaggatc gcaagagcca cgtagaagct gcatcttgtt tatacctttg ccttggaagt

2881 tgcatggcat cacctccacc atactccatc agttagagct gacacaaacc tgcctgggtt

2941 taaggggaga ggaaatattg ctggggtcat ttatgaaaaa tacagtttgt cacatgaaac

3001 atttgcaaaa ttgtttttgg ttggattgga gaagtaatcc tagggaaggg tggtggagcc

3061 agtaaataga ggagtacagg tgaagcacca agctcaaagc gtggacaggt gtgccgacag

3121 aaggaaccag cgtgtatatg agggtatcaa ataaaattgc tactacttac ctacc

(2) INFORMATION FOR SEQ ID NO: 101: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3568 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 101: atgcctgacc tcaactcctc cactgactct gcagcctcag cctctgcagc cagtgatgtt

61 tctgtagaat ctacagcaga ggccacagtc tgcacggtga cactggagaa gatgtcggca

121 gggctgggct tcagcctgga aggagggaag ggctccctac acggagacaa gcccctcacc

181 attaacagga ttttcaaagg agcagcctca gaacaaagtg agacagtcca gcctggagat

241 gaaatcttgc agctgggtgg cactgccatg cagggcctca cacggtttga agcctggaac

301 atcatcaagg cactgcctga tggacctgtc acgattgtca tcaggagaaa aagcctccag

361 tccaaggaaa ccacagctgc tggagactcc tag tgcttaaaaa aacacaacag gattttcgaa gaatcctttc ttagaaaaca aacaaaaaaa

61 ccaaacaaaa acgtactttc tccccactag tttacaccac aggaagcgag agagctgctg

121 ccactgctgc taccacagga agacacagca gggagaagcc ctagtgcctc tgccggctgc

181 ccaggacctg gtatcggccc acagaccaag tcctccacag agggcgagcc agggtggaga

241 agagccagcc cagtgaccca aacatccccg ataaaacacc cactgcttaa gaggcaggct

301 cggatggact atagctttga taccacagcc gaagaccctt gggttaggat ttctgactgc

361 atcaaaaact tatttagccc catcatgagt gagaaccatg gccacatgcc tctacagccc

421 aatgccagcc tgaatgaaga agaagggaca cagggccacc cagatgggac cccaccaaag

481 ctggacaccg ccaatggcac tcccaaagtt tacaagtcag cagacagcag cactgtgaag

541 aaaggtcctc ctgtggctcc caagccagcc tggtttcgcc aaagcttgaa aggtttgagg

601 aatcgtgctt cagagccaag agggctccct gatcctgcct tgtccaccca gccagcacct

661 gcttccaggg agcacctagg atcacacatc cgggcctcct cctcctcctc ctccatcagg

721 cagagaatca gctcctttga aacctttggc tcctctcaac tgcctgacaa aggagcccag

781 agactgagcc tccagccctc ctctggggag gcagcaaaac ctcttgggaa gcatgaggaa

841 ggacggtttt ctggactctt ggggcgaggg gctgcaccca ctcttgtgcc ccagcagcct

901 gagcaagtac tgtcctcggg gtcccctgca gcctccgagg ccagagaccc aggtgtgtct

961 gagtcccctc ccccagggcg gcagcccaat cagaaaactt tcccccctgg cccggacccg

1021 ctcctaaggc tgctgtcaac acaggctgag gaatctcaag gcccagtgct caagatgcct

1081 agccagcgag cacggagctt ccccctgacc aggtcccagt cctgtgagac gaagctactt

1141 gacgaaaaga ccagcaaact ctattctatc agcagccaag tgtcatcggc tgtcatgaaa

1201 tccttgctgt gccttccatc ttctatctcc tgtgcccaga ctccctgcat ccccaaggca

1261 ggggcatctc caacatcatc atccaacgaa gactcagctg caaatggttc tgctgaaaca

1321 tctgccttgg acacggggtt ctcgctcaac ctttcagagc tgagagaata tacagagggt

1381 ctcacggaag ccaaggaaga cgatgatggg gaccacagtt cccttcagtc tggtcagtcc

1441 gttatctccc tgctgagctc agaagaatta aaaaaactca tcgaggaggt gaaggttctg

1501 gatgaagcaa cattaaagca attagacggc atccatgtca ccatcttaca caaggaggaa

1561 ggtgctggtc ttgggttcag cttggcagga ggagcagatc tagaaaacaa ggtgattacg

1621 gttcacagag tgtttccaaa tgggctggcc tcccaggaag ggactattca gaagggcaat

1681 gaggttcttt ccatcaacgg caagtctctc aaggggacca cgcaccatga tgccttggcc

1741 atcctccgcc aagctcgaga gcccaggcaa gctgtgattg tcacaaggaa gctgactcca

1801 gaggccatgc ccgacctcaa ctcctccact gactctgcag cctcagcctc tgcagccagt

1861 gatgtttctg tagaatctac agcagaggcc acagtctgca cggtgacact ggagaagatg

1921 tcggcagggc tgggcttcag cctggaagga gggaagggct ccctacacgg agacaagcct

1981 ctcaccatta acaggatttt caaaggagca gcctcagaac aaagtgagac agtccagcct

2041 ggagatgaaa tcttgcagct gggtggcact gccatgcagg gcctcacacg gtttgaagcc

2101 tggaacatca tcaaggcact gcctgatgga cctgtcacga ttgtcatcag gagaaaaagc

2161 ctccagtcca aggaaaccac agctgctgga gactcctagg caggacatgc tgaagccaaa

2221 gccaataaca cacagctaac acacagctcc cataaccgct gattctcagg gtctctgctg

2281 ccgccccacc cagatggggg aaagcacagg tgggcttccc agtggctgct gcccaggccc

2341 agaccttcta ggacgccacc cagcaaaagg ttgttcctaa aataagggca gagtcacact

2401 ggggcagctg atacaaattg cagactgtgt aaaaagagag cttaatgata atattgtggt

2461 gccacaaata aaatggattt attagaattc catatgacat tcatgcctgg cttcgcaaaa

2521 tgtttcaagt actgtaactg tgtcatgatt cacccccaaa cagtgacatt tatttttctc

2581 atgaatctgc aatgtgggca gagattggaa tgggcagctc atctctgtcc cacttggcat

2641 cagctggcgt catgcaaagt catgcaaagg ctgggaccac ctgagatcat tcactcatac

2701 atctggccgt tgatgttggc tgggaactca cctggggctg ctggcctgaa tgcttatagg

2761 tggcctctcc ttgtggcctg ggctcctcac aacatggtgt ctggattccc aggatgagca

2821 tcccaggatc gcaagagcca cgtagaagct gcatcttgtt tatacctttg ccttggaagt

2881 tgcatggcat cacctccacc atactccatc agttagagct gacacaaacc tgcctgggtt

2941 taaggggaga ggaaatattg ctggggtcat ttatgaaaaa tacagtttgt cacatgaaac

3001 atttgcaaaa ttgtttttgg ttggattgga gaagtaatcc tagggaaggg tggtggagcc 3061 agtaaataga ggagtacagg tgaagcacca agctcaaagc gtggacaggt gtgccgacag 3121 aaggaaccag cgtgtatatg agggtatcaa ataaaattgc tactacttac ctacc

(2) INFORMATION FOR SEQ ID NO: 102: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 9203 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 102: gaattcatgc cacaactgag tgattttttt tttctcaaac ccaattccac aaagtaaaag

61 cctgatgaaa tacagtgaag gctgatgctt attaactgtg tttcccaaat ccagagctct

121 aaaaaggttc tgcatacagt cattcattca atgcttaacg actgagcatt aattccatgc

181 taagtactga actcagcact aggaataaga aggcgaccta gaggcatatc ctctctctaa

241 agatgcatag agcctcattg gaatgatcag ccgtgtctcc agagagctac aaggcagttt

301 tcaattggta aatgccctga gagtgatggg cttgtggcat gtgtaagggt tagacagacc

361 tgggacctag acatgacacc actcctgacg aattatgtga gtgtgggtgt ttcacaacca

421 caatgagatg caatgcctgc acttgtaaca tggaaatagt gatggcatgc cccgcagatt

481 gctgtgagaa gtcagcggca gagacatgca acattctcag cacagtgctt gccatgtagt

541 aagggcctag tcagtgctag tgattccttt caatattcct aagatgcaga taagggaaca

601 gcccagagga gggggagcac ttccagaggg aggaatgcgg tgagacttcc ttcagcaggg

661 tagcactgga gctgggtgtt aaggagtgag tgagctttgg gcttatggat ttaacagagg

721 aaaccaagaa aagaggaggc ggtgttgcag gaacagtgag cagttgatga tttttatttt

781 gttctctggt ctgcttggga acatttttgt ggcaaagaca gcatgaagga tagcgaagaa

841 ttaatactga agagataggc cagggcaggt tatgaaggat tttgaatacc gggctaagaa

901 atgtgggctt aatttcaaag acattatgga cactcctaaa atgttacgtt gtagataagg

961 gaaaagtatt cttccagaag attaaattgg ggctgggcac ggtggctcac gcctgtgatc

1021 ccagcacttt gggaggcgaa gtgggcagat cacctgaggt caggagtttg agatcagcct

1081 ggccaacgtg gtgaagcccc atctctactg aaaaaaaaaa ttagccgggc atggtggtgg

1141 gtgcctgtaa tctcagctac ttgggaggct gaagcaggag aatcacatga acctgggagg

1201 cagaggttgc agtgagccaa gattgcacca ctgcattcca gtgggcgaca gagcaagact

1261 cagtcaaaaa aaaaaaaaga ttaaactgga agcaatgggt aagaatggtg gagtggagag

1321 acacatttga gtgagggaag ccagctgaaa agctgtacag acgtctagac aaaatgtgac

1381 acaagcatgc cttcacctcc ctgcaaagac cacagaccac tgagctccaa agggggtttg

1441 gaatccttgt cctgggccgc cattggtaac tcatcagtgc tggcttgaga gataaactct

1501 attatccatc cctgaactaa aatcatgaca gaagtggcca gggagctttg ctgctatccc

1561 cccaggaaac acgtcctcca ctcaaatgga aagaggaccc tctgacaaca tctgtgggac

1621 ccaacagcac tggtcaccac aagccacaaa atgttaacaa agtcagtttt caattgttag

1681 ggacggagga ctcagttcat gattcataca aaccaactgt tctctcccag tgttttctgg

1741 gtggcacaac ccacaagtca acagtggctt gggaactaga catttgagta gagttgggtt

1801 atttgattca tagtggattt tggttttcca cgggacccct gtgcccttgt ctagtagaat

1861 ctggtggaaa ttacaaactg cagaaattca actcagtgcc gcaataacag gatgcacctg

1921 tagatttcgt agaattagca gcagcattct ttcaatacca gtttgagaga aataaccctg

1981 tttgcatagt gccaactggg gcagaatctg aagtgtcttg cctgcctctc ggccatggga

2041 ggcaccgatc tcagcaacat ctatccaacc gccatccact taacaagcaa agatggaagg

2101 ccctcgtgct ccaggctatc ctgcaatggt tcatttgctt ttgatgggat tatcactttg

2161 acagatgtgc ttgcaattaa ctgggggctt tctgcttcca atccaaattc ccacaggtgg

2221 atcactggct cttggggagc aaaaaccctt ctttgtttgt ttttgcttct cccagagcct

2281 gggcagagct ccccattcct ggatcctacg ttgatatgca ctgaattgaa ttatactaaa

2341 gggtgcaccc aagagtgcat gagctaagta aaatgtaatt tgtgggacct catgtggaca

2401 tttcaggtcc atgtgtacaa gataaaggag agaaaatcct gggggacacc acaggcctgg

2461 gaaaatgacc tcctactaag cctaacaaga acatccagta cataaacagc aggctctctg

2521 caaccgcttc ggtccttcca ctgccacgct cccagaaagc aaagggttat ctcctgttcg

2581 gattttggct ctgagaccac agctcagcac atcactcctc tagagaaaag aaagtctaag

2641 atgagagagt gaggctgctt tcatgtggtg ccagcgtata gtgcagggca ggcctgattg

2701 ctgaacggat ccctgcagac gtgagcggtc acttcccctt ttgagggccc atttcttttc

2761 ctctttgagg agactgtgag cgtcctcagt gcagggctat gttttagctt cttggctctc

2821 ctcacaggtt ctagcataat tctttgatta attgcagtca acgtttattg atggattatg

2881 tgacagaggt gaaattcttt gatctgggtt tcagcttttc ctttccccca ctccctcctt

2941 tttctttttt tttttttttt tttttagagg cgaggtcttg ctctgtggcc ctggctggag

3001 tgcagtggtg caatcatagc tcattgcagc cttgacctcc tggggtcaag cgaacctcaa

3061 cgtcttggcc tcctgagtag ctgggactat aggcatgcgc caccacgctc agcttcacct

3121 tttcctttcc ttgtgctccc ctggcagata tgctggtaaa caatgaacca gtcaagagga

3181 cagcaacagg aggaaaatgg gagaaacccc attattcgtg gactaaacag gcttcccact

3241 agtcctggct cacagaggaa gtcatgctcc atgtttcaaa tgtcctcaaa gctcgttcaa

3301 ctccaaaatg catgaagaca aaatgggaat tttactcaag atttttgtgg gctgttgggg

3361 agaagagtta acattgcaaa gcatattgca aactcttatc ttcaaatgat tttaaaattt

3421 tcttccaagc tctttattat ttctccagag ctgccctgct cttcccactc tgggtccttt

3481 ctctgccact ctcctcagca tgacttctcc ctaatcggcc agcatttctt ttattctata

3541 gagcaagttt tcttgccctg ggcacctctc atttgcatgt tataccacca caccaagtga

3601 gcctcagagc accagtgttt taatccctga aaacagtcct tacgggattc agcacagagg

3661 tcctcttggc agcctgtagt ctccagagtg acacgtcctc aacagtcaaa gtgagcaagc

3721 tatggtgccc atcaccaagt ggggctcacc atttccctct gcgttcactt ctctcctacc

3781 ttcttcctta tcccatcctt cctccttcct ttttttttct gcattcaatt attcatggtt

3841 attcatttca tacgggcatc tgtgccactt ggttctacag gcattttttt ttttgagaca 3901 gacttttgcc cttgtccccc aggctggcgt gcagcggtgt gatcttggct cactgcaatc 3961 tccacctcct aggttcaagc aagtctcctg ccttagcctc ccaagtagct ggaattacag 4021 gcatgtgcca ccaagcccgg caaatttttg tatttttagt agagacaggg tttcaccatg 4081 ttggccaggc tggtctcaaa ctcctgacct caggtgatct gcctgcctcg gcctcccaaa 4141 gtgctgggat aacaggcgtg agccatcgtg ctcggccggt tctatgggca ttgtggaagt 4201 gaccgttaac aagccccaag ggtaagtaaa ggaaaatgaa aggtgattga ttcctcacca 4261 cctctcccct tttttcctct actctttgcc cctgctcccc aatctagact ctaataaaca 4321 gaaatgattt ttgttgcaag ctgaaaactc gttcttgtgg ttggggctag gggggtggca 4381 agtcaagctt tagagttgtc tggataataa atgctgtctt caaggactgt ccaacattgt 4441 aggaacaaga gaacaaccca agtgaacaac taactcctgt tcacaaatgc tactgcctct 4501 ctgccatccc ctaacctcag cctcacacac ttgaatttcg ccaatccatt tgatgagctc 4561 aaatcagtga attttctcct cgccaaagct cacaaattct gttccccgct tcttgcccca 4621 catccaggca ttaccaactg cattttccct ttgcctgata ttctggcatc aagcctcctt 4681 gccattccaa tttatttcac cttcctccag tccttatgat ttccttcctg aagagtattt 4741 cagcatctct atgcctcaat cttccctgca caccacacca gctcggcctc atcatcacat 4801 tacttggcta tgtcccgcct gggttagaca gcttcagtgg ctgaagtcca tagatcttat 4861 tctgtttttc gaggtccacc tgactctgaa tccagctgac atttctgccc ttagcttcta 4921 cccctctcta cttctggtta actatggacc acactctgct tcctcaggaa ccacctacca 4981 aggccgtatc catccttcaa ggacaatacg tgggcctttc ctgatcacat cagctcaaca 5041 acttttccct cctacatttc aattgctctt cttaccataa tcattagtat tcaccccact 5101 gtacgtctag aaagaaagtg gtcttaaacc taagggaagg cagtctaggt cagaaatttg 5161 ttgtccgctg ttctgagcag tttcttctag gaagtaccaa acatttctga taatagaatt 5221 gagcaatttc ctgatgaagt gagactcagc ttgcactgtt gaccggctgt cctggatgaa 5281 cctagttact tttaaccaaa tgttcctttc ttgaacttgt tcctttcttg aacttaatct 5341 atcaatgtta tctagataac tttcctcaaa aaaaaaaaaa aaaaaaaaaa ccctctacta 5401 ggaaagaaat ctttgaaccg gacttattgg aaattacctc cttgcagcag gtttgaaaca 5461 aaactttgaa tttgcctcac aaagaatttg tctgaaactg ctttagtata tgctagttat 5521 atttgtatgc acatgtggct tcatacatag tggttggaca cccatatgtg ttatgcactt 5581 tgttaggtga cgtaagttca cagataaact ggaacatagg gctatcctct agaggcccac 5641 agtttgacac cttaacctga gatccttgga cctttgaagt tcagagtgcc cacaaccgct 5701 gggtgtggtg gctcacactt gtaatcccag tactctgcag ggctgaggtg ggaggatcgc 5761 ttgagtccag gagtctgaga ccagcctggg caacatgaca aaaccccatc tctacaaaaa 5821 ttacaaaaaa aattagccag gcctggtggt gcatgcctgt ggtcccagtt acttgagagg 5881 ctgaagtggg aggatcactt gagtcaagga ggtagaggct gcagtgagtt gagatggcaa 5941 cactgcactc cagaaacccc atctcaaaca aaacagagca aaacaaaaca aactgcccat 6001 aatgctcctg aaacttccta cggatttatc cagagtatgt gctgatgtgc attttttcca 6061 aggagggaaa ccaaaggttc tatcaaatta agaaaagagt ttttaccatt gtggaagaca 6121 gtatggcgat tcctcaagca tctaaaatca gaaataccat ttgacccagc aatcctatta 6181 ctgggtatat acccaaagga atagaaatca ttctactata aagtcacatg caaccgtatg 6241 tttattgcag cactatttac aatagcaaaa tggaaccaac tgaaatgccc atcaatgaga 6301 ctagataaag aaaatgtgat acatatacac catggaatac tatgcagcca tgaaaaggaa 6361 tgagatcacg tccttggcag ggacatggat gaagctggaa gccattatcc tcagcaaact 6421 aacacaggaa cagaaaacca aatgccgcat gttctcactc ataagtggga gttgaacaat 6481 gacagcacat agacataggg aggggaacat cacacgccag ggcctgctgc agggtggggg 6541 gtggggtgtg aggggaggga acttagaaga caggtgagta ggtgcagcag accaccatgg 6601 cacacttata cctatgtaac caacctgcac gttctacaca tgtatcctgg aacttaaatt 6661 aaaaacaaaa aagagttttt aatccaagaa agattaacag caactagaag aaagaaagag 6721 atataaacag tgaattgcaa tgcagcacgg caggtgttat gatggagtag aaaggactgg 6781 aaaaggcctc ctggaggaag ggacactcaa gtgtctttcc atttcacctg taaactcatt 6841 aagggcaaaa gctttgctac agcttcagta tgagatcctg ggcaatccgt gacaaaatgg 6901 gtctgctttt gcacccccaa cttcttctca catccctgca tcgtgccatg cagcatcaac 6961 tggaaacctc agcgtcagca aacgacgaca gagcgttcat ccgtaaggtg aaccagaaaa 7021 gccagttcaa tgacttgttt aaccatggtc catctcagaa ccaagagttg ggcctcttat 7081 ttaccagaaa aattgtgggg gctttgtgat atggctttaa aaaaatcttg taattgccag 7141 gcgtggtggc tcacacctgt aatcccagca ctttgggagg ccgaggtggg tgaatcgcct 7201 aaggtcagga gttcgagacc agcctgacca acatggtgaa actccgtctc tactaaaaat 7261 acaaaaacta gctggatgtg gtgacgcgtg cctgtaatcc tagctactca ggaggctgac 7321 gcaggagaat cacttgaacc tgggaggcag aggttgcagt gagccaagat tgtgccattg 7381 cgctccaaaa aaaaaaaaaa aatacattaa cataaattta aatattttat aatgacaatc 7441 cacattaact acttaaagca taagctattt tccaggagag gcagcaagtg cattctactc 7501 ccatgcccaa gaagaaagga gcgtgacttt ggtgggagta ctaggagttt ctactggagc 7561 acttgcccgc agagtgagaa acgttcctag agaggaagtt atacctgctg tggaatttaa 7621 gagaatcttg tcatattttg acaagttttt tgagatggaa gtctcactct gtcgcccagg 7681 ctggagtgca gtggcgcaat ctcagctcac tgcagcctgc acctcctcgg ttccagctat 7741 tctcttgtct cagcctcctg agtaactggg attacaggcg cccgccacta cgcctggcta 7801 atttttgtat ttttagtaga aatggggttt taccatgttg gccagactgg tctcaaactc 7861 ccgacctcag gtgatctgcc tgcctcagcc tcccaaagtg ctggaattac aggcgtgtgc 7921 cactgcgcct ggctaatttt tttttttttt tttttttagt agagacggtg gtttcaccat 7981 gtcatccagg ctggtctcaa actcctgacc tcaggtgatc cacccacctt ggtctaccaa 8041 agtgctcgga ttacaggcat gagccaccag gcccagtcaa cgtgatgtgt tttggaaccc 8101 tgaattcctt ggcttgccgg agggttttct ttttgttaat atctttgctt gctttctagt 8161 atttaaaaaa ttgtgttttg ctctaactat gcaatggctt taagtcttag acaaatttcc 8221 agggagcaaa acacactcaa ccaatttcat aataatcaga agagagctct gatcaataaa 8281 taagcaagac tgaattttac aaaataatcc aaagtttaaa accaaagccc actttttgca 8341 tgatccttta agagaaagaa atctggaagc aaaacacctt ataaaatgac aatgcacttt 8401 caggagccca gggcactgtg gtgaaatgat gatggctagt acaggttata agccttgggg 8461 aattatttat gaattctcag gatccttcag ttcgccgcat ccttctccat tatttσaata 8521 ttggaggctg cctgaccaga atcttgtcag gactttgctc cttcatccca ggtggtcccg 8581 gctgactcct gaggacgtta cagccctgag gggaggactc agcttatgaa gtgctgggtg 8641 agaccactgc caagaagtgc ttgctcaccc taccttcaac ggcaggggaa tctccctctc 8701 cttttatggg cgtagctgaa gaaaggattc ataaatgaag ttcaatcctt ctcatcaacc 8761 ccagcccaca cctccagcaa ttgaacttga aaaaaaaaac ctggtttgaa aaattaccgc 8821 aaactatatt gtcatcaaaa aaaaaaaaaa aaaaacactt cctatatttg agatgagaga 8881 agagagtgct aggcagtttc ctggctgaac acgccagccc aatacttaaa gagagcaact 8941 cctgactccg atagagactg gatggaccca caagggtgac agcccaggcg gaccgatctt 9001 cccatcccac atcctccggc gcgatgccaa aaagaggctg acggcaactg ggccttctgc 9061 agagaaagac ctccgcttca ctgccccggc tggtcccaag ggtcaggaag atggattcat 9121 acctgctgat gtggggactg ctcacgttca tcatggtgcc tggctgccag gcaggtaagg 9181 gcctgtgggt gcccccggaa ttc

INFORMATION FOR SEQ ID NO: 103: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2335 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 103:

1 gaattccccc cccccccccc cgagagactg gatggaccca caagggtgac agcccaggcg

61 gaccgatctt cccatcccac atcctccggc gcgatgccaa aaagaggctg acggcaactg

121 ggccttctgc agagaaagac ctccgcttca ctgccccggc tggtcccaag ggtcaggaag

181 atggattcat acctgctgat gtggggactg ctcacgttca tcatggtgcc tggctgccag

241 gcagagctct gtgacgatga cccgccagag atcccacacg ccacattcaa agccatggcc

301 tacaaggaag gaaccatgtt gaactgtgaa tgcaagagag gtttccgcag aataaaaagc

361 gggtcactct atatgctctg tacaggaaac tctagccact cgtcctggga caaccaatgt

421 caatgcacaa gctctgccac tcggaacaca acgaaacaag tgacacctca acctgaagaa

481 cagaaagaaa ggaaaaccac agaaatgcaa agtccaatgc agccagtgga ccaagcgagc

541 cttccaggtc actgcaggga acctccacca tgggaaaatg aagccacaga gagaatttat

601 catttcgtgg tggggcagat ggtttattat cagtgcgtcc agggatacag ggctctacac

661 agaggtcctg ctgagagcgt ctgcaaaatg acccacggga agacaaggtg gacccagccc

721 cagctcatat gcacaggtga aatggagacc agtcagtttc caggtgaaga gaagcctcag

781 gcaagccccg aaggccgtcc tgagagtgag acttcctgcc tcgtcacaac aacagatttt

841 caaatacaga cagaaatggc tgcaaccatg gagacgtcca tatttacaac agagtaccag

901 gtagcagtgg ccggctgtgt tttcctgctg atcagcgtcc tcctcctgag tgggctcacc

961 tggcagcgga gacagaggaa gagtagaaga acaatctaga aaaccaaaag aacaagaatt

1021 tcttggtaag aagccgggaa cagacaacag aagtcatgaa gcccaagtga aatcaaaggt

1081 gctaaatggt cgcccaggag acatccgttg tgcttgcctg cgttttggaa gctctgaagt

1141 cacatcacag gacacggggc agtggcaacc ttgtctctat gccagctcag tcccatcaga

1201 gagcgagcgc tacccacttc taaatagcaa tttcgccgtt gaagaggaag ggcaaaacca

1261 ctagaactct ccatcttatt ttcatgtata tgtgttcatt aaagcatgaa tggtatggaa

1321 ctctctccac cctatatgta gtataaagaa aagtaggttt acattcatct cattccaact

1381 tcccagttca ggagtcccaa ggaaagcccc agcactaacg taaatacaca acacacacac

1441 tctaccctat acaactggac attgtctgcg tggttccttt ctcagccgct tctgactgct

1501 gattctcccg ttcacgttgc ctaataaaca tccttcaaga actctgggct gctacccaga

1561 aatcatttta cccttggctc aatcctctaa gctaaccccc ttctactgag ccttcagtct

1621 tgaatttcta aaaaacagag gccatggcag aataatcttt gggtaacttc aaaacggggc

1681 agccaaaccc atgaggcaat gtcaggaaca gaaggatgaa tgaggtccca ggcagagaat

1741 catacttagc aaagttttac ctgtgcgtta ctaattggcc tctttaagag ttagtttctt

1801 tgggattgct atgaatgata ccctgaattt ggcctgcact aatttgatgt ttacaggtgg

1861 acacacaagg tgcaaatcaa tgcgtacgtt tcctgagaag tgtctaaaaa caccaaaaag

1921 ggatccgtac attcaatgtt tatgcaagga aggaaagaaa gaaggaagtg aagagggaga

1981 agggatggag gtcacactgg tagaacgtaa ccacggaaaa gagcgcatca ggcctggcac

2041 ggtggctcag gcctataacc ccagctccct aggagaccaa ggcgggagca tctcttgagg

2101 ccaggagttt gagaccagcc tgggcagcat agcaagacac atccctacaa aaaattagaa

2161 attggctgga tgtggtggca tacgcctgta gtcctagcca ctcaggaggc tgaggcagga

2221 ggattgcttg agcccaggag ttcgaggctg cagtcagtca tgatggcacc actgcactcc

2281 agcctgggca acagagcaag atcctgtctt taaggaaaaa aagacaaggg aattc

(2) INFORMATION FOR SEQ ID NO: 104: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1092 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 104: gaattcatgg aaatgggaag ggcagtgatg gagatgggaa gggcagtggg ggttggaggg

61 gtggggattg ttgttgggta cgaaaacaga attagatcga atgaataaga tctagtattt 121 gatagcataa cagggtgact ttagtcaaca ataatttatt gtacatttaa aaataactaa 181 aagagtatac ttggatttta acacaaagaa aggataaata cttgaggtga tggatacccc 241 atttaccctg atgtgattat tatacattgt atgcctgtat caaaatagct catgtgcctc 301 atgaatatag acacctacca catgcccaca aaattaaaaa ctaaaaaaaa cagtcatctc

361 tgaatgctaa acggagtaag gggcttcctg gaaggctggg tgaaatggga gtctcggaaa

421 gatggtgtgt tgcaggctgg gaggagggtg agacgctggg gtcacctaga gggacctgct

481 tgtgtgaagc ctacgtatta gtgggtatgt gtgtgaccgg atggaggcgt cagaggtgtt

541 gggtagcctg tgtgagttgg cgtgggggtg atgtaggagg ggagagaggg agggcctgcg

601 ttcccttggc tcctgtgtgc agctaggccc ctatttgaca atgtgtgtct gtgtgtgtgt

661 gtgtgtgtgt gtgtgtgtgt gtgtgccgcc cccagcgtag gaggcagatc tttatctggc

721 cctgggtgct tgaggagttt caggctttct cataagcctc gtctccccgc ctctccaccc

781 caggccttgc ccctctatcc tctgcacagg aagtgggctg gctctgggct tttagtcttt

841 gcggccccag cagccagagc tcagcagggc cctggagaga tggccacggt cccagcaccg

901 gggaggactg gagagcgcgc gctgccaccg ccccatgtct cagccaggtg atgtccccct

961 gcctccctcc cggcccctgt ggaccagcca gagggctggg agtgaaagtc acagagaaga

1021 ctttcagctc tgactcagtt cccccagcag tttctgcctg aactcccatc ccccaacttt

1081 gtcttagaat tc

(2) INFORMATION FOR SEQ ID NO: 105: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1451 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 105: gaagagcaag cgccatgttg aagccatcat taccattcac atccctctta ttcctgcagc

61 tgcccctgct gggagtgggg ctgaacacga caattctgac gcccaatggg aatgaagaca

121 ccacagctga tttcttcctg accactatgc ccactgactc cctcagtgtt tccactctgc

181 ccctcccaga ggttcagtgt tttgtgttca atgtcgagta catgaattgc acttggaaca

241 gcagctctga gccccagcct accaacctca ctctgcatta ttggtacaag aactcggata

301 atgataaagt ccagaagtgc agccactatc tattctctga agaaatcact tctggctgtc

361 agttgcaaaa aaaggagatc cacctctacc aaacatttgt tgttcagctc caggacccac

421 gggaacccag gagacaggcc acacagatgc taaaactgca gaatctggtg atcccctggg

481 ctccagagaa cctaacactt cacaaactga gtgaatccca gctagaactg aactggaaca

541 acagattctt gaaccactgt ttggagcact tggtgcagta ccggactgac tgggaccaca

601 gctggactga acaatcagtg gattatagac ataagttctc cttgcctagt gtggatgggc

661 agaaacgcta cacgtttcgt gttcggagcc gctttaaccc actctgtgga agtgctcagc

721 attggagtga atggagccac ccaatccact gggggagcaa tacttcaaaa gagaatcctt

781 tcctgtttgc attggaagcc gtggttatct ctgttggctc catgggattg attatcagcc

841 ttctctgtgt gtatttctgg ctggaacgga cgatgccccg aattcccacc ctgaagaacc

901 tagaggatct tgttactgaa taccacggga acttttcggc ctggagtggt gtgtctaagg

961 gactggctga gagtctgcag ccagactaca gtgaacgact ctgcctcgtc agtgagattc

1021 ccccaaaagg aggggccctt ggggaggggc ctggggcctc cccatgcaac cagcatagcc

1081 cctactgggc ccccccatgt tacaccctaa agcctgaaac ctgaacccca atcctctgac

1141 agaagaaccc cagggtcctg tagccctaag tggtactaac tttccttcat tcaacccacc

1201 tgcgtctcat actcacctca ccccactgtg gctgatttgg aattttgtgc ccccatgtaa

1261 gcaccccttc atttggcatt ccccacttga gaattaccct tttgccccga acatgttttt

1321 cttctccctc agtctggccc ttccttttcg caggattctt cctccctccc tctttccctc

1381 ccttcctctt tccatctacc ctccgattgt tcctgaaccg atgagaaata aagtttctgt

1441 tgataatcat c

(2) INFORMATION FOR SEQ ID NO: 106: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1563 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 106: gagagactgg atggacccac aagggtgaca gcccaggcgg accgatcttc ccatcccaca

61 tcctccggcg cgatgccaaa aagaggctga cggcaactgg gccttctgca gagaaagacc

121 tccgcttcac tgccccggct ggtcccaagg gtcaggaaga tggattcata cctgctgatg

181 tggggactgc tcacgttcat catggtgcct ggctgccagg cagagctctg tgacgatgac

241 ccgccagaga tcccacacgc cacattcaaa gccatggcct acaaggaagg aaccatgttg

301 aactgtgaat gcaagagagg tttccgcaga ataaaaagcg ggtcactcta tatgctctgt

361 acaggaaact ctagccactc gtcctgggac aaccaatgtc aatgcacaag ctctgccact

421 cggaacacaa cgaaacaagt gacacctcaa cctgaagaac agaaagaaag gaaaaccaca

481 gaaatgcaaa gtccaatgca gccagtggac caagcgagcc ttccaggtga agagaagcct

541 caggcaagcc ccgaaggccg tcctgagagt gagacttcct gcctcgtcac aacaacagat

601 tttcaaatac agacagaaat ggctgcaacc atggagacgt ccatatttac aacagagyac

661 caggtagcag tggccggctg tgttttcctg ctgatcagcg tcctcctcct gagtgggctc

721 acctggcagc ggagacagag gaagagtaga agaacaatct agaaaaccaa aagaacaaga

781 atttcttggt aagaagccgg gaacagacaa cagaagtcat gaagcccaag tgaaatcaaa

841 ggtgctaaat ggtcgcccag gagacatccg ttgtgcttgc ctgcgttttg gaagctctga

901 agtcacatca caggacacgg ggcagtggca accttgtctc tatgccagct cagtcccatc

961 agagagcgag cgctacccac ttctaaatag caatttcgcc gttgaagagg aagggcaaaa

1021 ccactagaac tctccatctt attttcatgt atatgtgttc attaaagcat gaatggtatg

1081 gaactctctc caccctatat gtagtataaa gaaaagtagg tttacattca tctcattcca

1141 acttcccagt tcaggagtcc caaggaaagc cccagcacta acgtaaatac acaacacaca 1201 cactctaccc tatacaactg gacattgtct gcgtggttcc tttctcagcc gcttctgact

1261 gctgattctc ccgttcacgt tgcctaataa acatccttca agaactctgg gctgctaccc

1321 agaaatcatt ttacccttgg ctcaatcctc taagctaacc cccttccact gagccttcag

1381 tcttgaattt ctaaaaaaca gaggccatgg cagaataatc tttgggtaac ttcaaaacgg

1441 ggcagccaaa cccatgaggc aatgtcagga acagaaggat gaatgaggtc ccaggcagag

1501 aatcatactt agcaaagttt tacctgtgcg ttactaattg gcctctttaa gagttagttt

1561 ctt

(2) INFORMATION FOR SEQ ID NO: 107: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 733 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 107: gaattctcag gatccttcag ttcgccgcat ccttctccat tatttgaata ttggaggctg 61 cctgaccaga atcttgtcag gactttgctc cttcatccca ggtggtcccg gctgactcct 121 gaggacgtta cagccctgag gggaggactc agccttatga agtgctgggt gagaccactg 181 ccaagaagtg cttgctcacc ctaccttcaa cggcagggga atctccctct ccttttatgg 241 gcgtagtgaa gaaaggattc ataaatgaag ttcaatcctt ctcatcaacc ccagcccaca 301 cctccagcaa ttgaacttga aaaaaaaaac ctggtttgaa aaattaccgc aaactatatt 361 gtcatcaaaa aaaaaaaaaa aaaaacactt cctatatttg agatgagaga agagagtgct 421 aggcagtttc ctggctgaac acgccagccc aatacttaaa gagagcaact cctgactccg 481 atagagactg gatggaccca caagggtgac agcccaggcg gaccgatctt cccatcccac 541 atcctccggc gcgatgccaa aaagaggctg acggcaactg ggccttctgc agagaaagac 601 ctccgcttca ctgccccggc tggtcccaag ggtcaggaag atggattcat acctgctgat 661 gtggggactg ctcacgttca tcatggtgcc tggctgccag gcaggtaagg gcctgtgggt 721 gcccccggaa ttc

(2) INFORMATION FOR SEQ ID NO: 108: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 756 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi (SEQUENCE DESCRIPTION: SEQ ID NO :108: gagctctgtg acgatgaccc gccagagatc ccacacgcca cattcaaagc catggcctac 61 aaggaaggaa ccatgttgaa ctgtgaatgc aagagaggtt tccgcagaat aaaaagcggg 121 tcactctata tgctctgtac aggaaactct agccactcgt cctgggacaa ccaatgtcaa 181 tgcacaagct ctgccactcg gaacacaacg aaacaagtga cacctcaacc tgaagaacag 241 aaagaaagga aaaccacaga aatgcaaagt ccaatgcagc cagtggacca agcgagcctt 301 ccaggtcact gcaaggaacc tccaccatgg gaaaatgaag ccacagagag aatttatcat 361 ttcgtggtgg ggcagatggt ttattatcag tgcgtccagg gatacagggc tctacacaga 421 ggtcctgctg agagcgtctg caaaatgacc cacgggaaga caaggtggac ccagccccag 481 ctcatatgca caggtgaaat ggagaccagt cagtttccag gtgaagagaa gcctcaggca 541 agccccgaag gccgtcctga gagtgagact tcctgcctcg tcacaacaac agattttcaa 601 atacagacag aaatggctgc aaccatggag acgtccatat ttacaacaga gtaccaggta 661 gcagtggccg gctgtgtttt cctgctgatc agcgtcctcc tcctgagtgg gctcacctgg 721 cagcagagac agaggaagag tagaagaaca atctag

(2) INFORMATION FOR SEQ ID NO:109: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 711 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 109: gaattctcag gatccttcag ttcgccgcat ccttctccat tatttgaata ttggaggctg

61 cctgaccaga atcttgtcag gactttgctc cttcatccca ggtggtcccg gctgactcct 121 gaggacgtta cagccctgag ggaggactca gcttatgaag tgctgggtga gaccactgcc 181 aagaagtgct tgctcaccta ccttcaacgg caggggaatc tccctctcct tttatgggcg 241 tagctgaaga aaggattcat aaatgaagtt caatccttct catcacccca gcccaacctc 301 cagcaattga acttgaaaaa aaaaacctgg tttgaaaaat taccgcaaac tatattgtca 361 tcaaaaaaaa aaaaaaaaaa aaacacttcc tatatttgag atgagagaag agagtgctag 421 gcagtttcct ggctgaacac gccagcccaa tacttaaaga gagcaactcc tgactccgat 481 agagactgga tggacccaca agggtgacag cccaggcgga ccgatcttcc catcccacat 541 cctccggcgc gatgccaaaa agaggctgac ggcaactggg ccttctgcag agaaagacct 601 ccgcttcact gccccggctg gtcccaaggg tcaggaagat ggattcatac ctgctgatgt 661 ggggactgct cacgttcatc atggtgcctg gctgccaggc aggtaagggc c

(2) INFORMATION FOR SEQ ID NO: 110: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18200 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 110: gaattcatgc cacaactgag tgattttttt tttctcaaac ccaattccac aaagtaaaag

61 cctgatgaaa tacagtgaag gctgatgctt attaactgtg tttcccaaat ccagagctct

121 aaaaaggttc tgcatacagt cattcattca atgcttaacg actgagcatt aattccatgc

181 taagtactga actcagcact aggaataaga aggcgaccta gaggcatatc ctctctctaa

241 agatgcatag agcctcattg gaatgatcag ccgtgtctcc agagagctac aaggcagttt

301 tcaattggta aatgccctga gagtgatggg cttgtggcat gtgtaagggt tagacagacc

361 tgggacctag acatgacacc actcctgacg aattatgtga gtgtgggtgt ttcacaacca

421 caatgagatg caatgcctgc acttgtaaca tggaaatagt gatggcatgc cccgcagatt

481 gctgtgagaa gtcagcggca gagacatgca acattctcag cacagtgctt gccatgtagt

541 aagggcctag tcagtgctag tgattccttt caatattcct aagatgcaga taagggaaca

601 gcccagagga gggggagcac ttccagaggg aggaatgcgg tgagacttcc ttcagcaggg

661 tagcactgga gctgggtgtt aaggagtgag tgagctttgg gcttatggat ttaacagagg

721 aaaccaagaa aagaggaggc ggtgttgcag gaacagtgag cagttgatga tttttatttt

781 gttctctggt ctgcttggga acatttttgt ggcaaagaca gcatgaagga tagcgaagaa

841 ttaatactga agagataggc cagggcaggt tatgaaggat tttgaatacc gggctaagaa

901 atgtgggctt aatttcaaag acattatgga cactcctaaa atgttacgtt gtagataagg

961 gaaaagtatt cttccagaag attaaattgg ggctgggcac ggtggctcac gcctgtgatc

1021 ccagcacttt gggaggcgaa gtgggcagat cacctgaggt caggagtttg agatcagcct

1081 ggccaacgtg gtgaagcccc atctctactg aaaaaaaaaa ttagccgggc atggtggtgg

1141 gtgcctgtaa tctcagctac ttgggaggct gaagcaggag aatcacatga acctgggagg

1201 cagaggttgc agtgagccaa gattgcacca ctgcattcca gtgggcgaca gagcaagact

1261 cagtcaaaaa aaaaaaaaga ttaaactgga agcaatgggt aagaatggtg gagtggagag

1321 acacatttga gtgagggaag ccagctgaaa agctgtacag acgtctagac aaaatgtgac

1381 acaagcatgc cttcacctcc ctgcaaagac cacagaccac tgagctccaa agggggtttg

1441 gaatccttgt cctgggccgc cattggtaac tcatcagtgc tggcttgaga gataaactct

1501 attatccatc cctgaactaa aatcatgaca gaagtggcca gggagctttg ctgctatccc

1561 cccaggaaac acgtcctcca ctcaaatgga aagaggaccc tctgacaaca tctgtgggac

1621 ccaacagcac tggtcaccac aagccacaaa atgttaacaa agtcagtttt caattgttag

1681 ggacggagga ctcagttcat gattcataca aaccaactgt tctctcccag tgttttctgg

1741 gtggcacaac ccacaagtca acagtggctt gggaactaga catttgagta gagttgggtt

1801 atttgattca tagtggattt tggttttcca cgggacccct gtgcccttgt ctagtagaat

1861 ctggtggaaa ttacaaactg cagaaattca actcagtgcc gcaataacag gatgcacctg

1921 tagatttcgt agaattagca gcagcattct ttcaatacca gtttgagaga aataaccctg

1981 tttgcatagt gccaactggg gcagaatctg aagtgtcttg cctgcctctc ggccatggga

2041 ggcaccgatc tcagcaacat ctatccaacc gccatccact taacaagcaa agatggaagg

2101 ccctcgtgct ccaggctatc ctgcaatggt tcatttgctt ttgatgggat tatcactttg

2161 acagatgtgc ttgcaattaa ctgggggctt tctgcttcca atccaaattc ccacaggtgg

2221 atcactggct cttggggagc aaaaaccctt ctttgtttgt ttttgcttct cccagagcct

2281 gggcagagct ccccattcct ggatcctacg ttgatatgca ctgaattgaa ttatactaaa

2341 gggtgcaccc aagagtgcat gagctaagta aaatgtaatt tgtgggacct catgtggaca

2401 tttcaggtcc atgtgtacaa gataaaggag agaaaatcct gggggacacc acaggcctgg

2461 gaaaatgacc tcctactaag cctaacaaga acatccagta cataaacagc aggctctctg

2521 caaccgcttc ggtccttcca ctgccacgct cccagaaagc aaagggttat ctcctgttcg

2581 gattttggct ctgagaccac agctcagcac atcactcctc tagagaaaag aaagtctaag

2641 atgagagagt gaggctgctt tcatgtggtg ccagcgtata gtgcagggca ggcctgattg

2701 ctgaacggat ccctgcagac gtgagcggtc acttcccctt ttgagggccc atttcttttc

2761 ctctttgagg agactgtgag cgtcctcagt gcagggctat gttttagctt cttggctctc

2821 ctcacaggtt ctagcataat tctttgatta attgcagtca acgtttattg atggattatg

2881 tgacagaggt gaaattcttt gatctgggtt tcagcttttc ctttccccca ctccctcctt

2941 tttctttttt tttttttttt tttttagagg cgaggtcttg ctctgtggcc ctggctggag

3001 tgcagtggtg caatcatagc tcattgcagc cttgacctcc tggggtcaag cgaacctcaa

3061 cgtcttggcc tcctgagtag ctgggactat aggcatgcgc caccacgctc agcttcacct

3121 tttcctttcc ttgtgctccc ctggcagata tgctggtaaa caatgaacca gtcaagagga

3181 cagcaacagg aggaaaatgg gagaaacccc attattcgtg gactaaacag gcttcccact

3241 agtcctggct cacagaggaa gtcatgctcc atgtttcaaa tgtcctcaaa gctcgttcaa

3301 ctccaaaatg catgaagaca aaatgggaat tttactcaag atttttgtgg gctgttgggg

3361 agaagagtta acattgcaaa gcatattgca aactcttatc ttcaaatgat tttaaaattt

3421 tcttccaagc tctttattat ttctccagag ctgccctgct cttcccactc tgggtccttt

3481 ctctgccact ctcctcagca tgacttctcc ctaatcggcc agcatttctt ttattctata

3541 gagcaagttt tcttgccctg ggcacctctc atttgcatgt tataccacca caccaagtga

3601 gcctcagagc accagtgttt taatccctga aaacagtcct tacgggattc agcacagagg

3661 tcctcttggc agcctgtagt ctccagagtg acacgtcctc aacagtcaaa gtgagcaagc

3721 tatggtgccc atcaccaagt ggggctcacc atttccctct gcgttcactt ctctcctacc

3781 ttcttcctta tcccatcctt cctccttcct ttttttttct gcattcaatt attcatggtt

3841 attcatttca tacgggcatc tgtgccactt ggttctacag gcattttttt ttttgagaca

3901 gacttttgcc cttgtccccc aggctggcgt gcagcggtgt gatcttggct cactgcaatc 3961 tccacctcct aggttcaagc aagtctcctg ccttagcctc ccaagtagct ggaattacag

4021 gcatgtgcca ccaagcccgg caaatttttg tatttttagt agagacaggg tttcaccatg

4081 ttggccaggc tggtctcaaa ctcctgacct caggtgatct gcctgcctcg gcctcccaaa

4141 gtgctgggat aacaggcgtg agccatcgtg ctcggccggt tctatgggca ttgtggaagt

4201 gaccgttaac aagccccaag ggtaagtaaa ggaaaatgaa aggtgattga ttcctcacca

4261 cctctcccct tttttcctct actctttgcc cctgctcccc aatctagact ctaataaaca

4321 gaaatgattt ttgttgcaag ctgaaaactc gttcttgtgg ttggggctag gggggtggca

4381 agtcaagctt tagagttgtc tggataataa atgctgtctt caaggactgt ccaacattgt

4441 aggaacaaga gaacaaccca agtgaacaac taactcctgt tcacaaatgc tactgcctct

4501 ctgccatccc ctaacctcag cctcacacac ttgaatttcg ccaatccatt tgatgagctc

4561 aaatcagtga attttctcct cgccaaagct cacaaattct gttccccgct tcttgcccca

4621 catccaggca ttaccaactg cattttccct ttgcctgata ttctggcatc aagcctcctt

4681 gccattccaa tttatttcac cttcctccag tccttatgat ttccttcctg aagagtattt

4741 cagcatctct atgcctcaat cttccctgca caccacacca gctcggcctc atcatcacat

4801 tacttggcta tgtcccgcct gggttagaca gcttcagtgg ctgaagtcca tagatcttat

4861 tctgtttttc gaggtccacc tgactctgaa tccagctgac atttctgccc ttagcttcta

4921 cccctctcta cttctggtta actatggacc acactctgct tcctcaggaa ccacctacca

4981 aggccgtatc catccttcaa ggacaatacg tgggcctttc ctgatcacat cagctcaaca

5041 acttttccct cctacatttc aattgctctt cttaccataa tcattagtat tcaccccact

5101 gtacgtctag aaagaaagtg gtcttaaacc taagggaagg cagtctaggt cagaaatttg

5161 ttgtccgctg ttctgagcag tttcttctag gaagtaccaa acatttctga taatagaatt

5221 gagcaatttc ctgatgaagt gagactcagc ttgcactgtt gaccggctgt cctggatgaa

5281 cctagttact tttaaccaaa tgttcctttc ttgaacttgt tcctttcttg aacttaatct

5341 atcaatgtta tctagataac tttcctcaaa aaaaaaaaaa aaaaaaaaaa ccctctacta

5401 ggaaagaaat ctttgaaccg gacttattgg aaattacctc cttgcagcag gtttgaaaca

5461 aaactttgaa tttgcctcac aaagaatttg tctgaaactg ctttagtata tgctagttat

5521 atttgtatgc acatgtggct tcatacatag tggttggaca cccatatgtg ttatgcactt

5581 tgttaggtga cgtaagttca cagataaact ggaacatagg gctatcctct agaggcccac

5641 agtttgacac cttaacctga gatccttgga cctttgaagt tcagagtgcc cacaaccgct

5701 gggtgtggtg gctcacactt gtaatcccag tactctgcag ggctgaggtg ggaggatcgc

5761 ttgagtccag gagtctgaga ccagcctggg caacatgaca aaaccccatc tctacaaaaa

5821 ttacaaaaaa aattagccag gcctggtggt gcatgcctgt ggtcccagtt acttgagagg

5881 ctgaagtggg aggatcactt gagtcaagga ggtagaggct gcagtgagtt gagatggcaa

5941 cactgcactc cagaaacccc atctcaaaca aaacagagca aaacaaaaca aactgcccat

6001 aatgctcctg aaacttccta cggatttatc cagagtatgt gctgatgtgc attttttcca

6061 aggagggaaa ccaaaggttc tatcaaatta agaaaagagt ttttaccatt gtggaagaca

6121 gtatggcgat tcctcaagca tctaaaatca gaaataccat ttgacccagc aatcctatta

6181 ctgggtatat acccaaagga atagaaatca ttctactata aagtcacatg caaccgtatg

6241 tttattgcag cactatttac aatagcaaaa tggaaccaac tgaaatgccc atcaatgaga

6301 ctagataaag aaaatgtgat acatatacac catggaatac tatgcagcca tgaaaaggaa

6361 tgagatcacg tccttggcag ggacatggat gaagctggaa gccattatcc tcagcaaact

6421 aacacaggaa cagaaaacca aatgccgcat gttctcactc ataagtggga gttgaacaat

6481 gacagcacat agacataggg aggggaacat cacacgccag ggcctgctgc agggtggggg

6541 gtggggtgtg aggggaggga acttagaaga caggtgagta ggtgcagcag accaccatgg

6601 cacacttata cctatgtaac caacctgcac gttctacaca tgtatcctgg aacttaaatt

6661 aaaaacaaaa aagagttttt aatccaagaa agattaacag caactagaag aaagaaagag

6721 atataaacag tgaattgcaa tgcagcacgg caggtgttat gatggagtag aaaggactgg

6781 aaaaggcctc ctggaggaag ggacactcaa gtgtctttcc atttcacctg taaactcatt

6841 aagggcaaaa gctttgctac agcttcagta tgagatcctg ggcaatccgt gacaaaatgg

6901 gtctgctttt gcacccccaa cttcttctca catccctgca tcgtgccatg cagcatcaac

6961 tggaaacctc agcgtcagca aacgacgaca gagcgttcat ccgtaaggtg aaccagaaaa

7021 gccagttcaa tgacttgttt aaccatggtc catctcagaa ccaagagttg ggcctcttat

7081 ttaccagaaa aattgtgggg gctttgtgat atggctttaa aaaaatcttg taattgccag

7141 gcgtggtggc tcacacctgt aatcccagca ctttgggagg ccgaggtggg tgaatcgcct

7201 aaggtcagga gttcgagacc agcctgacca acatggtgaa actccgtctc tactaaaaat

7261 acaaaaacta gctggatgtg gtgacgcgtg cctgtaatcc tagctactca ggaggctgac

7321 gcaggagaat cacttgaacc tgggaggcag aggttgcagt gagccaagat tgtgccattg

7381 cgctccaaaa aaaaaaaaaa aatacattaa cataaattta aatattttat aatgacaatc

7441 cacattaact acttaaagca taagctattt tccaggagag gcagcaagtg cattctactc

7501 ccatgcccaa gaagaaagga gcgtgacttt ggtgggagta ctaggagttt ctactggagc

7561 acttgcccgc agagtgagaa acgttcctag agaggaagtt atacctgctg tggaatttaa

7621 gagaatcttg tcatattttg acaagttttt tgagatggaa gtctcactct gtcgcccagg

7681 ctggagtgca gtggcgcaat ctcagctcac tgcagcctgc acctcctcgg ttccagctat

7741 tctcttgtct cagcctcctg agtaactggg attacaggcg cccgccacta cgcctggcta

7801 atttttgtat ttttagtaga aatggggttt taccatgttg gccagactgg tctcaaactc

7861 ccgacctcag gtgatctgcc tgcctcagcc tcccaaagtg ctggaattac aggcgtgtgc

7921 cactgcgcct ggctaatttt tttttttttt tttttttagt agagacggtg gtttcaccat

7981 gtcatccagg ctggtctcaa actcctgacc tcaggtgatc cacccacctt ggtctaccaa 8041 agtgctcgga ttacaggcat gagccaccag gcccagtcaa cgtgatgtgt tttggaaccc

8101 tgaattcctt ggcttgccgg agggttttct ttttgttaat atctttgctt gctttctagt

8161 atttaaaaaa ttgtgttttg ctctaactat gcaatggctt taagtcttag acaaatttcc

8221 agggagcaaa acacactcaa ccaatttcat aataatcaga agagagctct gatcaataaa

8281 taagcaagac tgaattttac aaaataatcc aaagtttaaa accaaagccc actttttgca

8341 tgatccttta agagaaagaa atctggaagc aaaacacctt ataaaatgac aatgcacttt

8401 caggagccca gggcactgtg gtgaaatgat gatggctagt acaggttata agccttgggg

8461 aattatttat gaattctcag gatccttcag ttcgccgcat ccttctccat tatttgaata

8521 ttggaggctg cctgaccaga atcttgtcag gactttgctc cttcatccca ggtggtcccg

8581 gctgactcct gaggacgtta cagccctgag gggaggactc agcttatgaa gtgctgggtg

8641 agaccactgc caagaagtgc ttgctcaccc taccttcaac ggcaggggaa tctccctctc

8701 cttttatggg cgtagctgaa gaaaggattc ataaatgaag ttcaatcctt ctcatcaacc

8761 ccagcccaca cctccagcaa ttgaacttga aaaaaaaaac ctggtttgaa aaattaccgc

8821 aaactatatt gtcatcaaaa aaaaaaaaaa aaaaacactt cctatatttg agatgagaga

8881 agagagtgct aggcagtttc ctggctgaac acgccagccc aatacttaaa gagagcaact

8941 cctgactccg atagagactg gatggaccca caagggtgac agcccaggcg gaccgatctt

9001 cccatcccac atcctccggc gcgatgccaa aaagaggctg acggcaactg ggccttctgc

9061 agagaaagac ctccgcttca ctgccccggc tggtcccaag ggtcaggaag atggattcat

9121 acctgctgat gtggggactg ctcacgttca tcatggtgcc tggctgccag gcaggtaagg

9181 gcctgtgggt gcccccggaa ttc

1 gaattccccc cccccccccc cgagagactg gatggaccca caagggtgac agcccaggcg

61 gaccgatctt cccatcccac atcctccggc gcgatgccaa aaagaggctg acggcaactg

121 ggccttctgc agagaaagac ctccgcttca ctgccccggc tggtcccaag ggtcaggaag

181 atggattcat acctgctgat gtggggactg ctcacgttca tcatggtgcc tggctgccag

241 gcagagctct gtgacgatga cccgccagag atcccacacg ccacattcaa agccatggcc

301 tacaaggaag gaaccatgtt gaactgtgaa tgcaagagag gtttccgcag aataaaaagc

361 gggtcactct atatgctctg tacaggaaac tctagccact cgtcctggga caaccaatgt

421 caatgcacaa gctctgccac tcggaacaca acgaaacaag tgacacctca acctgaagaa

481 cagaaagaaa ggaaaaccac agaaatgcaa agtccaatgc agccagtgga ccaagcgagc

541 cttccaggtc actgcaggga acctccacca tgggaaaatg aagccacaga gagaatttat

601 catttcgtgg tggggcagat ggtttattat cagtgcgtcc agggatacag ggctctacac

661 agaggtcctg ctgagagcgt ctgcaaaatg acccacggga agacaaggtg gacccagccc

721 cagctcatat gcacaggtga aatggagacc agtcagtttc caggtgaaga gaagcctcag

781 gcaagccccg aaggccgtcc tgagagtgag acttcctgcc tcgtcacaac aacagatttt

841 caaatacaga cagaaatggc tgcaaccatg gagacgtcca tatttacaac agagtaccag

901 gtagcagtgg ccggctgtgt tttcctgctg atcagcgtcc tcctcctgag tgggctcacc

961 tggcagcgga gacagaggaa gagtagaaga acaatctaga aaaccaaaag aacaagaatt

1021 tcttggtaag aagccgggaa cagacaacag aagtcatgaa gcccaagtga aatcaaaggt

1081 gctaaatggt cgcccaggag acatccgttg tgcttgcctg cgttttggaa gctctgaagt

1141 cacatcacag gacacggggc agtggcaacc ttgtctctat gccagctcag tcccatcaga

1201 gagcgagcgc tacccacttc taaatagcaa tttcgccgtt gaagaggaag ggcaaaacca

1261 ctagaactct ccatcttatt ttcatgtata tgtgttcatt aaagcatgaa tggtatggaa

1321 ctctctccac cctatatgta gtataaagaa aagtaggttt acattcatct cattccaact

1381 tcccagttca ggagtcccaa ggaaagcccc agcactaacg taaatacaca acacacacac

1441 tctaccctat acaactggac attgtctgcg tggttccttt ctcagccgct tctgactgct

1501 gattctcccg ttcacgttgc ctaataaaca tccttcaaga actctgggct gctacccaga

1561 aatcatttta cccttggctc aatcctctaa gctaaccccc ttctactgag ccttcagtct

1621 tgaatttcta aaaaacagag gccatggcag aataatcttt gggtaacttc aaaacggggc

1681 agccaaaccc atgaggcaat gtcaggaaca gaaggatgaa tgaggtccca ggcagagaat

1741 catacttagc aaagttttac ctgtgcgtta ctaattggcc tctttaagag ttagtttctt

1801 tgggattgct atgaatgata ccctgaattt ggcctgcact aatttgatgt ttacaggtgg

1861 acacacaagg tgcaaatcaa tgcgtacgtt tcctgagaag tgtctaaaaa caccaaaaag

1921 ggatccgtac attcaatgtt tatgcaagga aggaaagaaa gaaggaagtg aagagggaga

1981 agggatggag gtcacactgg tagaacgtaa ccacggaaaa gagcgcatca ggcctggcac

2041 ggtggctcag gcctataacc ccagctccct aggagaccaa ggcgggagca tctcttgagg

2101 ccaggagttt gagaccagcc tgggcagcat agcaagacac atccctacaa aaaattagaa

2161 attggctgga tgtggtggca tacgcctgta gtcctagcca ctcaggaggc tgaggcagga

2221 ggattgcttg agcccaggag ttcgaggctg cagtcagtca tgatggcacc actgcactcc

2281 agcctgggca acagagcaag atcctgtctt taaggaaaaa aagacaaggg aattc gaattcatgg aaatgggaag ggcagtgatg gagatgggaa gggcagtggg ggttggaggg

61 gtggggattg ttgttgggta cgaaaacaga attagatcga atgaataaga tctagtattt

121 gatagcataa cagggtgact ttagtcaaca ataatttatt gtacatttaa aaataactaa

181 aagagtatac ttggatttta acacaaagaa aggataaata cttgaggtga tggatacccc

241 atttaccctg atgtgattat tatacattgt atgcctgtat caaaatagct catgtgcctc

301 atgaatatag acacctacca catgcccaca aaattaaaaa ctaaaaaaaa cagtcatctc

361 tgaatgctaa acggagtaag gggcttcctg gaaggctggg tgaaatggga gtctcggaaa

421 gatggtgtgt tgcaggctgg gaggagggtg agacgctggg gtcacctaga gggacctgct

481 tgtgtgaagc ctacgtatta gtgggtatgt gtgtgaccgg atggaggcgt cagaggtgtt 541 gggtagcctg tgtgagttgg cgtgggggtg atgtaggagg ggagagaggg agggcctgcg

601 ttcccttggc tcctgtgtgc agctaggccc ctatttgaca atgtgtgtct gtgtgtgtgt

661 gtgtgtgtgt gtgtgtgtgt gtgtgccgcc cccagcgtag gaggcagatc tttatctggc

721 cctgggtgct tgaggagttt caggctttct cataagcctc gtctccccgc ctctccaccc

781 caggccttgc ccctctatcc tctgcacagg aagtgggctg gctctgggct tttagtcttt

841 gcggccccag cagccagagc tcagcagggc cctggagaga tggccacggt cccagcaccg

901 gggaggactg gagagcgcgc gctgccaccg ccccatgtct cagccaggtg atgtccccct

961 gcctccctcc cggcccctgt ggaccagcca gagggctggg agtgaaagtc acagagaaga

1021 ctttcagctc tgactcagtt cccccagcag tttctgcctg aactcccatc ccccaacttt

1081 gtcttagaat tc gaagagcaag cgccatgttg aagccatcat taccattcac atccctctta ttcctgcagc

61 tgcccctgct gggagtgggg ctgaacacga caattctgac gcccaatggg aatgaagaca

121 ccacagctga tttcttcctg accactatgc ccactgactc cctcagtgtt tccactctgc

181 ccctcccaga ggttcagtgt tttgtgttca atgtcgagta catgaattgc acttggaaca

241 gcagctctga gccccagcct accaacctca ctctgcatta ttggtacaag aactcggata

301 atgataaagt ccagaagtgc agccactatc tattctctga agaaatcact tctggctgtc

361 agttgcaaaa aaaggagatc cacctctacc aaacatttgt tgttcagctc caggacccac

421 gggaacccag gagacaggcc acacagatgc taaaactgca gaatctggtg atcccctggg

481 ctccagagaa cctaacactt cacaaactga gtgaatccca gctagaactg aactggaaca

541 acagattctt gaaccactgt ttggagcact tggtgcagta ccggactgac tgggaccaca

601 gctggactga acaatcagtg gattatagac ataagttctc cttgcctagt gtggatgggc

661 agaaacgcta cacgtttcgt gttcggagcc gctttaaccc actctgtgga agtgctcagc

721 attggagtga atggagccac ccaatccact gggggagcaa tacttcaaaa gagaatcctt

781 tcctgtttgc attggaagcc gtggttatct ctgttggctc catgggattg attatcagcc

841 ttctctgtgt gtatttctgg ctggaacgga cgatgccccg aattcccacc ctgaagaacc

901 tagaggatct tgttactgaa taccacggga acttttcggc ctggagtggt gtgtctaagg

961 gactggctga gagtctgcag ccagactaca gtgaacgact ctgcctcgtc agtgagattc

1021 ccccaaaagg aggggccctt ggggaggggc ctggggcctc cccatgcaac cagcatagcc

1081 cctactgggc ccccccatgt tacaccctaa agcctgaaac ctgaacccca atcctctgac

1141 agaagaaccc cagggtcctg tagccctaag tggtactaac tttccttcat tcaacccacc

1201 tgcgtctcat actcacctca ccccactgtg gctgatttgg aattttgtgc ccccatgtaa

1261 gcaccccttc atttggcatt ccccacttga gaattaccct tttgccccga acatgttttt

1321 cttctccctc agtctggccc ttccttttcg caggattctt cctccctccc tctttccctc

1381 ccttcctctt tccatctacc ctccgattgt tcctgaaccg atgagaaata aagtttctgt

1441 tgataatcat c gagagactgg atggacccac aagggtgaca gcccaggcgg accgatcttc ccatcccaca

61 tcctccggcg cgatgccaaa aagaggctga cggcaactgg gccttctgca gagaaagacc

121 tccgcttcac tgccccggct ggtcccaagg gtcaggaaga tggattcata cctgctgatg

181 tggggactgc tcacgttcat catggtgcct ggctgccagg cagagctctg tgacgatgac

241 ccgccagaga tcccacacgc cacattcaaa gccatggcct acaaggaagg aaccatgttg

301 aactgtgaat gcaagagagg tttccgcaga ataaaaagcg ggtcactcta tatgctctgt

361 acaggaaact ctagccactc gtcctgggac aaccaatgtc aatgcacaag ctctgccact

421 cggaacacaa cgaaacaagt gacacctcaa cctgaagaac agaaagaaag gaaaaccaca

481 gaaatgcaaa gtccaatgca gccagtggac caagcgagcc ttccaggtga agagaagcct

541 caggcaagcc ccgaaggccg tcctgagagt gagacttcct gcctcgtcac aacaacagat

601 tttcaaatac agacagaaat ggctgcaacc atggagacgt ccatatttac aacagagyac

661 caggtagcag tggccggctg tgttttcctg ctgatcagcg tcctcctcct gagtgggctc

721 acctggcagc ggagacagag gaagagtaga agaacaatct agaaaaccaa aagaacaaga

781 atttcttggt aagaagccgg gaacagacaa cagaagtcat gaagcccaag tgaaatcaaa

841 ggtgctaaat ggtcgcccag gagacatccg ttgtgcttgc ctgcgttttg gaagctctga

901 agtcacatca caggacacgg ggcagtggca accttgtctc tatgccagct cagtcccatc

961 agagagcgag cgctacccac ttctaaatag caatttcgcc gttgaagagg aagggcaaaa

1021 ccactagaac tctccatctt attttcatgt atatgtgttc attaaagcat gaatggtatg

1081 gaactctctc caccctatat gtagtataaa gaaaagtagg tttacattca tctcattcca

1141 acttcccagt tcaggagtcc caaggaaagc cccagcacta acgtaaatac acaacacaca

1201 cactctaccc tatacaactg gacattgtct gcgtggttcc tttctcagcc gcttctgact

1261 gctgattctc ccgttcacgt tgcctaataa acatccttca agaactctgg gctgctaccc

1321 agaaatcatt ttacccttgg ctcaatcctc taagctaacc cccttccact gagccttcag

1381 tcttgaattt ctaaaaaaca gaggccatgg cagaataatc tttgggtaac ttcaaaacgg

1441 ggcagccaaa cccatgaggc aatgtcagga acagaaggat gaatgaggtc ccaggcagag

1501 aatcatactt agcaaagttt tacctgtgcg ttactaattg gcctctttaa gagttagttt

1561 ctt gaattctcag gatccttcag ttcgccgcat ccttctccat tatttgaata ttggaggctg

61 cctgaccaga atcttgtcag gactttgctc cttcatccca ggtggtcccg gctgactcct 121 gaggacgtta cagccctgag gggaggactc agccttatga agtgctgggt gagaccactg 181 ccaagaagtg cttgctcacc ctaccttcaa cggcagggga atctccctct ccttttatgg 241 gcgtagtgaa gaaaggattc ataaatgaag ttcaatcctt ctcatcaacc ccagcccaca 301 cctccagcaa ttgaacttga aaaaaaaaac ctggtttgaa aaattaccgc aaactatatt 361 gtcatcaaaa aaaaaaaaaa aaaaacactt cctatatttg agatgagaga agagagtgct 421 aggcagtttc ctggctgaac acgccagccc aatacttaaa gagagcaact cctgactccg 481 atagagactg gatggaccca caagggtgac agcccaggcg gaccgatctt cccatcccac 541 atcctccggc gcgatgccaa aaagaggctg acggcaactg ggccttctgc agagaaagac 601 ctccgcttca ctgccccggc tggtcccaag ggtcaggaag atggattcat acctgctgat

661 gtggggactg ctcacgttca tcatggtgcc tggctgccag gcaggtaagg gcctgtgggt

721 gcccccggaa ttc gagctctgtg acgatgaccc gccagagatc ccacacgcca cattcaaagc catggcctac

61 aaggaaggaa ccatgttgaa ctgtgaatgc aagagaggtt tccgcagaat aaaaagcggg

121 tcactctata tgctctgtac aggaaactct agccactcgt cctgggacaa ccaatgtcaa

181 tgcacaagct ctgccactcg gaacacaacg aaacaagtga cacctcaacc tgaagaacag

241 aaagaaagga aaaccacaga aatgcaaagt ccaatgcagc cagtggacca agcgagcctt

301 ccaggtcact gcaaggaacc tccaccatgg gaaaatgaag ccacagagag aatttatcat

361 ttcgtggtgg ggcagatggt ttattatcag tgcgtccagg gatacagggc tctacacaga

421 ggtcctgctg agagcgtctg caaaatgacc cacgggaaga caaggtggac ccagccccag

481 ctcatatgca caggtgaaat ggagaccagt cagtttccag gtgaagagaa gcctcaggca

541 agccccgaag gccgtcctga gagtgagact tcctgcctcg tcacaacaac agattttcaa

601 atacagacag aaatggctgc aaccatggag acgtccatat ttacaacaga gtaccaggta

661 gcagtggccg gctgtgtttt cctgctgatc agcgtcctcc tcctgagtgg gctcacctgg

721 cagcagagac agaggaagag tagaagaaca atctag gaattctcag gatccttcag ttcgccgcat ccttctccat tatttgaata ttggaggctg

61 cctgaccaga atcttgtcag gactttgctc cttcatccca ggtggtcccg gctgactcct

121 gaggacgtta cagccctgag ggaggactca gcttatgaag tgctgggtga gaccactgcc

181 aagaagtgct tgctcaccta ccttcaacgg caggggaatc tccctctcct tttatgggcg

241 tagctgaaga aaggattcat aaatgaagtt caatccttct catcacccca gcccaacctc

301 cagcaattga acttgaaaaa aaaaacctgg tttgaaaaat taccgcaaac tatattgtca

361 tcaaaaaaaa aaaaaaaaaa aaacacttcc tatatttgag atgagagaag agagtgctag

421 gcagtttcct ggctgaacac gccagcccaa tacttaaaga gagcaactcc tgactccgat

481 agagactgga tggacccaca agggtgacag cccaggcgga ccgatcttcc catcccacat

541 cctccggcgc gatgccaaaa agaggctgac ggcaactggg ccttctgcag agaaagacct

601 ccgcttcact gccccggctg gtcccaaggg tcaggaagat ggattcatac ctgctgatgt

661 ggggactgct cacgttcatc atggtgcctg gctgccaggc aggtaagggc c

(2) INFORMATION FOR SEQ ID NO: 111: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 544 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 111: aagcttaata taaacaagtt tcttgtcact gccaccacca cgaccaaaaa aagctaatca

61 atcactatat ataatacata tatatactat atataataaa tatatatact atatataata 121 catatataca ctatatataa tacatatata ctatatatac actatatact atatatacac 181 atatatatta tgaatgtata tatatagtat atatagtata tatactatgt atgtatatat 241 agtatatata gtatatatac tatgtatgat atatagtata tatagtatat atactatgta 301 tgtgtatata tagtatatat agtatatata gtatatatac tatgtatgta tatatatagt 361 atatatagta tatatactgt gtatgtatat atatagtata tatatactat atatgcatac 421 atagtatata tgcatatata ctatatatac tatatattta tatatactat atactatata 481 tactatatac tgtatatata ctatatatgt atgtatacga tatatatata tactatatat 541 gtac

(2) INFORMATION FOR SEQ ID NO: 112: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2002 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 112: cagagaagct ctatctcccc tccaggagcc cagctatgaa ctccttctcc acaagcgcct

61 tcggtccagt tgccttctcc ctggggctgc tcctggtgtt gcctgctgcc ttccctgccc 121 cagtaccccc aggagaagat tccaaagatg tagccgcccc acacagacag ccactcacct 181 cttcagaacg aattgacaaa caaattcggt acatcctcga cggcatctca gccctgagaa 241 aggagacatg taacaagagt aacatgtgtg aaagcagcaa agaggcactg gcagaaaaca 301 acctgaacct tccaaagatg gctgaaaaag atggatgctt ccaatctgga ttcaatgagg 361 agacttgcct ggtgaaaatc atcactggtc ttttggagtt tgaggtatac ctagagtacc 421 tccagaacag atttgagagt agtgaggaac aagccagagc tgtgcagatg agtacaaaag 481 tcctgatcca gttcctgcag aaaaaggcaa agaatctaga tgcaataacc acccctgacc 541 caaccacaaa tgccagcctg ctgacgaagc tgcaggcaca gaaccagtgg ctgcaggaca 601 tgacaactca tctcattctg cgcagcttta aggagttcct gcagtccagc ctgagggctc 661 ttcggcaaat gtagcatggg cacctcagat tgttgttgtt aatgggcatt ccttcttctg 721 gtcagaaacc tgtccactgg gcacagaact tatgttgttc tctatggaga actaaaagta 781 tgagcgttag gacactattt taattatttt taatttatta atatttaaat atgtgaagct 841 gagttaattt atgtaagtga tatttatatt ttaagaagta ccacttgaaa cattttatgt 901 attagttttg aaataataat ggaaagtggc tatgcagttt gaatatcctt tgtttcagag 961 ccagatcatt tcttggaaag tgtacgctta cctcaaataa atggctaact tatacatatt

1021 tttaaagaaa tatttatatt gtatttatat aatgtataaa atggttttta taccaataaa

1081 tggcatttta aaaaattcag ca

(2) INFORMATION FOR SEQ ID NO: 113: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 113 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 113: gaattccggg aacgaaagag aagctctatc tcccctccag gagcccagct atgaactcct

61 tctccacaag cgccttcggt ccagttgcct tctccctggg gctgctcctg gtgttgcctg

121 ctgccttccc tgccccagta cccccaggag aagattccaa agatgtagcc gccccacaca

181 gacagccact cacctcttca gaacgaattg acaaacaaat tcggtacatc ctcgacggca

241 tctcagccct gagaaaggag acatgtaaca agagtaacat gtgtgaaagc agcaaagagg

301 cactggcaga aaacaacctg aaccttccaa agatggctga aaaagatgga tgcttccaat

361 ctggattcaa tgaggagact tgcctggtga aaatcatcac tggtcttttg gagtttgagg

421 tatacctaga gtacctccag aacagatttg agagtagtga ggaacaagcc agagctgtgc

481 agatgagtac aaaagtcctg atccagttcc tgcagaaaaa ggcaaagaat ctagatgcaa

541 taaccacccc tgacccaacc acaaatgcca gcctgctgac gaagctgcag gcacagaacc

601 agtggctgca ggacatgaca actcatctca ttctgcgcag ctttaaggag ttcctgcagt

661 ccagcctgag ggctcttcgg caaatgtagc atgggcacct cagattgttg ttgttaatgg

721 gcattccttc ttctggtcag aaacctgtcc actgggcaca gaacttatgt tgttctctat

781 ggagaactaa aagtatgagc gttaggacac tattttaatt atttttaatt tattaatatt

841 taaatatgtg aagctgagtt aatttatgta agtcatattt atatttttaa gaagtaccac

901 ttgaaacatt ttatgtatta gttttgaaat aataatggaa agtggctatg cagtttgaat

961 atcctttgtt tcagagccag atcatttctt ggaaagtgta ggcttacctc aaataaatgg

1021 ctaacttata catattttta aagaaatatt tatattgtat ttatataatg tataaatggt

1081 ttttatacca ataaatggca ttttaaaaaa ttc

(2) INFORMATION FOR SEQ ID NO: 114: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3659 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 114: aagcttaata taaacaagtt tcttgtcact gccaccacca cgaccaaaaa aagctaatca

61 atcactatat ataatacata tatatactat atataataaa tatatatact atatataata 121 catatataca ctatatataa tacatatata ctatatatac actatatact atatatacac 181 atatatatta tgaatgtata tatatagtat atatagtata tatactatgt atgtatatat 241 agtatatata gtatatatac tatgtatgat atatagtata tatagtatat atactatgta 301 tgtgtatata tagtatatat agtatatata gtatatatac tatgtatgta tatatatagt 361 atatatagta tatatactgt gtatgtatat atatagtata tatatactat atatgcatac 421 atagtatata tgcatatata ctatatatac tatatattta tatatactat atactatata 481 tactatatac tgtatatata ctatatatgt atgtatacga tatatatata tactatatat 541 gtac cagagaagct ctatctcccc tccaggagcc cagctatgaa ctccttctcc acaagcgcct

61 tcggtccagt tgccttctcc ctggggctgc tcctggtgtt gcctgctgcc ttccctgccc 121 cagtaccccc aggagaagat tccaaagatg tagccgcccc acacagacag ccactcacct 181 cttcagaacg aattgacaaa caaattcggt acatcctcga cggcatctca gccctgagaa 241 aggagacatg taacaagagt aacatgtgtg aaagcagcaa agaggcactg gcagaaaaca 301 acctgaacct tccaaagatg gctgaaaaag atggatgctt ccaatctgga ttcaatgagg 361 agacttgcct ggtgaaaatc atcactggtc ttttggagtt tgaggtatac ctagagtacc 421 tccagaacag atttgagagt agtgaggaac aagccagagc tgtgcagatg agtacaaaag 481 tcctgatcca gttcctgcag aaaaaggcaa agaatctaga tgcaataacc acccctgacc 541 caaccacaaa tgccagcctg ctgacgaagc tgcaggcaca gaaccagtgg ctgcaggaca 601 tgacaactca tctcattctg cgcagcttta aggagttcct gcagtccagc ctgagggctc 661 ttcggcaaat gtagcatggg cacctcagat tgttgttgtt aatgggcatt ccttcttctg 721 gtcagaaacc tgtccactgg gcacagaact tatgttgttc tctatggaga actaaaagta 781 tgagcgttag gacactattt taattatttt taatttatta atatttaaat atgtgaagct 841 gagttaattt atgtaagtga tatttatatt ttaagaagta ccacttgaaa cattttatgt 901 attagttttg aaataataat ggaaagtggc tatgcagttt gaatatcctt tgtttcagag 961 ccagatcatt tcttggaaag tgtacgctta cctcaaataa atggctaact tatacatatt 1021 tttaaagaaa tatttatatt gtatttatat aatgtataaa atggttttta taccaataaa 1081 tggcatttta aaaaattcag ca gaattccggg aacgaaagag aagctctatc tcccctccag gagcccagct atgaactcct

61 tctccacaag cgccttcggt ccagttgcct tctccctggg gctgctcctg gtgttgcctg 121 ctgccttccc tgccccagta cccccaggag aagattccaa agatgtagcc gccccacaca 181 gacagccact cacctcttca gaacgaattg acaaacaaat tcggtacatc ctcgacggca 241 tctcagccct gagaaaggag acatgtaaca agagtaacat gtgtgaaagc agcaaagagg 301 cactggcaga aaacaacctg aaccttccaa agatggctga aaaagatgga tgcttccaat 361 ctggattcaa tgaggagact tgcctggtga aaatcatcac tggtcttttg gagtttgagg 421 tatacctaga gtacctccag aacagatttg agagtagtga ggaacaagcc agagctgtgc 481 agatgagtac aaaagtcctg atccagttcc tgcagaaaaa ggcaaagaat ctagatgcaa 541 taaccacccc tgacccaacc acaaatgcca gcctgctgac gaagctgcag gcacagaacc 601 agtggctgca ggacatgaca actcatctca ttctgcgcag ctttaaggag ttcctgcagt 661 ccagcctgag ggctcttcgg caaatgtagc atgggcacct cagattgttg ttgttaatgg 721 gcattccttc ttctggtcag aaacctgtcc actgggcaca gaacttatgt tgttctctat 781 ggagaactaa aagtatgagc gttaggacac tattttaatt atttttaatt tattaatatt

841 taaatatgtg aagctgagtt aatttatgta agtcatattt atatttttaa gaagtaccac

901 ttgaaacatt ttatgtatta gttttgaaat aataatggaa agtggctatg cagtttgaat

961 atcctttgtt tcagagccag atcatttctt ggaaagtgta ggcttacctc aaataaatgg

1021 ctaacttata catattttta aagaaatatt tatattgtat ttatataatg tataaatggt

1081 ttttatacca ataaatggca ttttaaaaaa ttc

(2) INFORMATION FOR SEQ ID NO: 115: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1194 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(XI) SEQUENCE DESCRIPTION: SEQ ID NO: 115: ggatcctcct gcaagagaca ccatcctgag gggaagaggg cttctgaacc agcttgaccc

61 aataagaaat tcttgggtgc cgacggggac agcagattca gagcctagag ccgtgcctgc

121 gtccgtagtt tccttctagc ttctttttga tttcaaatca agacttacag ggagagggag

181 cgataaacac aaactctgca agatgccaca aggtcctcct ttgacatccc caacaaagaa

241 ggtgagtagt aatctccccc tttctgccct gaaccaagtg gcttcagtaa gtttcagggc

301 tccaggagac ctgggcatgc aggtgccgat gaaacagtgg tgaagagact cagtggcagt

361 ggcagtgggg agagcactcg cagcacaggc aaacctctgg cacaagagca aagtcctcac

421 tggaggattc ccaagggtca cttgggagag ggcaggcagc agccaacctc ctctaagtgg

481 gctgaagcag gtgaagaaat ggcagaagac gcggtggtgg caaaaaggag tcacacactc

541 cacctggaga cgccttgaag taactgcacg aaatttgagg gtggccaggc agttctacaa

601 cagccgcctc acagggagag ccagaacaca gcaagaactc agatgactgg tagtattacc

661 ttcttcataa tcccaggctt ggggggctgc gatggagtca gaggaaactc agttcagaac

721 atctttggtt tttacaatac aaattaactg gaacgctaaa ttctagcctg ttaatctggt

781 cactgaaaaa aaaaaaattt tttttttttc aaaaaacata gctttagctt attttttttt

841 tctctttgta aaacttcgtg catgacttca gctttactct tgtcaagaca tgccaagtgc

901 tgagtcacta ataaagaaaa aagaagtaaa ggaagagtgg ttctgcttct tagcgctagc

961 ctcaatgacg acctaagctg cacttttccc cctagttgtg tcttgcgatg ctaaaggacg

1021 tcattgcaca atcttaataa ggtttccaat cagccccacc cgctctggcc ccaccctcac

1081 cctccaacaa agatttatca aatgtgggat tttcccatga gtctcaatat tagagtctca

1141 acccccaata aatataggac tggagatgtc tctgaggctc attctgccct cgag

(2) INFORMATION FOR SEQ ID NO: 116: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3319 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xι)SEQUENCE DESCRIPTION: SEQ ID NO:116: ggcggtcccc tgttctcccc gctcaggtgc ggcgctgtgg caggaagcca ccccctcggt

61 cggccggtgc gcggggctgt tgcgccatcc gctccggctt tcgtaaccgc accctgggac

121 ggcccagaga cgctccagcg cgagttcctc aaatgttttc ctgcgttgcc aggaccgtcc

181 gccgctctga gtcatgtgcg agtgggaagt cgcactgaca ctgagccggg ccagagggag

241 aggagccgag cgcggcgcgg ggccgaggga ctcgcagtgt gtgtagagag ccgggctcct

301 gcggatgggg gctgcccccg gggcctgagc ccgcctgccc gcccaccgcc ccgccccgcc

361 cctgccaccc ctgccgcccg gttcccatta gcctgtccgc ctctgcggga ccatggagtg

421 gtagccgagg aggaagcatg ctggccgtcg gctgcgcgct gctggctgcc ctgctggccg

481 cgccgggagc ggcgctggcc ccaaggcgct gccctgcgca ggaggtggca agaggcgtgc

541 tgaccagtct gccaggagac agcgtgactc tgacctgccc gggggtagag ccggaagaca

601 atgccactgt tcactgggtg ctcaggaagc cggctgcagg ctcccacccc agcagatggg

661 ctggcatggg aaggaggctg ctgctgaggt cggtgcagct ccacgactct ggaaactatt

721 catgctaccg ggccggccgc ccagctggga ctgtgcactt gctggtggat gttccccccg

781 aggagcccca gctctcctgc ttccggaaga gccccctcag caatgttgtt tgtgagtggg

841 gtcctcggag caccccatcc ctgacgacaa aggctgtgct cttggtgagg aagtttcaga

901 acagtccggc cgaagacttc caggagccgt gccagtattc ccaggagtcc cagaagttct

961 cctgccagtt agcagtcccg gagggagaca gctctttcta catagtgtcc atgtgcgtcg

1021 ccagtagtgt cgggagcaag ttcagcaaaa ctcaaacctt tcagggttgt ggaatcttgc

1081 agcctgatcc gcctgccaac atcacagtca ctgccgtggc cagaaacccc cgctggctca

1141 gtgtcacctg gcaagacccc cactcctgga actcatcttt ctacagacta cggtttgagc

1201 tcagatatcg ggctgaacgg tcaaagacat tcacaacatg gatggtcaag gacctccagc

1261 atcactgtgt catccacgac gcctggagcg gcctgaggca cgtggtgcag cttcgtgccc

1321 aggaggagtt cgggcaaggc gagtggagcg agtggagccc ggaggccatg ggcacgcctt

1381 ggacagaatc caggagtcct ccagctgaga acgaggtgtc cacccccatg caggcactta

1441 ctactaataa agacgatgat aatattctct tcagagattc tgcaaatgcg acaagcctcc

1501 cagtgcaaga ttcttcttca gtaccactgc ccacattcct ggttgctgga gggagcctgg

1561 ccttcggaac gctcctctgc attgccattg ttctgaggtt caagaagacg tggaagctgc

1621 gggctctgaa ggaaggcaag acaagcatgc atccgccgta ctctttgggg cagctggtcc

1681 cggagaggcc tcgacccacc ccagtgcttg ttcctctcat ctccccaccg gtgtccccca

1741 gcagcctggg gtctgacaat acctcgagcc acaaccgacc agatgccagg gacccacgga

1801 gcccttatga catcagcaat acagactact tcttccccag atagctggct gggtggcacc

1861 agcagcctgg accctgtgga tgacaaaaca caaacgggct cagcaaaaga tgcttctcac

1921 tgccatgcca gcttatctca ggggtgtgcg gcctttggct tcacggaaga gccttgcgga 1981 aggttctacg ccaggggaaa atcagcctgc tccagctgtt cagctggttg aggtttcaaa

2041 cctccctttc caaatgccca gcttaaaggg gttagagtga acttgggcca ctgtgaagag

2101 aaccatatca agactctttg gacactcaca cggacactca aaagctgggc aggttggtgg

2161 gggcctcggt gtggagaagc ggctggcagc ccacccctca acacctctgc acaagctgca

2221 ccctcaggca ggtgggatgg atttccagcc aaagcctcct ccagccgcca tgctcctggc

2281 ccactgcatc gtttcatctt ccaactcaaa ctcttaaaac ccaagtgccc ttagcaaatt

2341 ctgtttttct aggcctgggg acggctttta cttaaacgcc aaggcctggg ggaagaagct

2401 ctctcctccc tttcttccct acagttcaaa aacagctgag ggtgagtggg tgaataatac

2461 agtatgtcag ggcctggtcg ttttcaacag aattataatt agttcctcat tagcagtttt

2521 gcctaaatgt gaatgatgat cctaggcatt tgctgaatac agaggcaact gcattggctt

2581 tgggttgcag gacctcaggt gagaagcaga ggaaggagag gagaggggca cagggtctct

2641 accatcccct gtagagtggg agctgagtgg gggatcacag cctctgaaaa ccaatgttct

2701 ctcttctcca cctcccacaa aggagagcta gcagcaggga gggcttctgc catttctgag

2761 atcaaaacgg ttttactgca gctttgtttg ttgtcagctg aacctgggta actagggaag

2821 ataatattaa ggaagacaat gtgaaaagaa aaatgagcct ggcaagaatg cgtttaaact

2881 tggtttttaa aaaactgctg actgttttct cttgagaggg tggaatatcc aatattcgct

2941 gtgtcagcat agaagtaact tacttaggtg tgggggaagc accataactt tgtttagccc

3001 aaaaccaagt caagtgaaaa aggaggaaga gaaaaaatat tttcctgcca ggcatggagg

3061 cccacgcact tcgggaggtc gaggcaggag gatcacttga gtccagaagt ttgagatcag

3121 cctgggcaat gtgataaaac cccatctcta caaaaagcat aaaaattagc caagtgtggt

3181 agagtgtgcc tgaagtccca gatacttggg gggctgaggt gggaggatct cttgagcctg

3241 ggaggtcaag gctgcagtga gccgagattg caccactgca ctccagcctg gggtgacaga

3301 gcaagtgaga ccctgtctc

(2) INFORMATION FOR SEQ ID NO: 117: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4413 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 117: ggatcctcct gcaagagaca ccatcctgag gggaagaggg cttctgaacc agcttgaccc

61 aataagaaat tcttgggtgc cgacggggac agcagattca gagcctagag ccgtgcctgc

121 gtccgtagtt tccttctagc ttctttttga tttcaaatca agacttacag ggagagggag

181 cgataaacac aaactctgca agatgccaca aggtcctcct ttgacatccc caacaaagaa

241 ggtgagtagt aatctccccc tttctgccct gaaccaagtg gcttcagtaa gtttcagggc

301 tccaggagac ctgggcatgc aggtgccgat gaaacagtgg tgaagagact cagtggcagt

361 ggcagtgggg agagcactcg cagcacaggc aaacctctgg cacaagagca aagtcctcac

421 tggaggattc ccaagggtca cttgggagag ggcaggcagc agccaacctc ctctaagtgg

481 gctgaagcag gtgaagaaat ggcagaagac gcggtggtgg caaaaaggag tcacacactc

541 cacctggaga cgccttgaag taactgcacg aaatttgagg gtggccaggc agttctacaa

601 cagccgcctc acagggagag ccagaacaca gcaagaactc agatgactgg tagtattacc

661 ttcttcataa tcccaggctt ggggggctgc gatggagtca gaggaaactc agttcagaac

721 atctttggtt tttacaatac aaattaactg gaacgctaaa ttctagcctg ttaatctggt

781 cactgaaaaa aaaaaaattt tttttttttc aaaaaacata gctttagctt attttttttt

841 tctctttgta aaacttcgtg catgacttca gctttactct tgtcaagaca tgccaagtgc

901 tgagtcacta ataaagaaaa aagaagtaaa ggaagagtgg ttctgcttct tagcgctagc

961 ctcaatgacg acctaagctg cacttttccc cctagttgtg tcttgcgatg ctaaaggacg

1021 tcattgcaca atcttaataa ggtttccaat cagccccacc cgctctggcc ccaccctcac

1081 cctccaacaa agatttatca aatgtgggat tttcccatga gtctcaatat tagagtctca

1141 acccccaata aatataggac tggagatgtc tctgaggctc attctgccct cgag ggcggtcccc tgttctcccc gctcaggtgc ggcgctgtgg caggaagcca ccccctcggt

61 cggccggtgc gcggggctgt tgcgccatcc gctccggctt tcgtaaccgc accctgggac

121 ggcccagaga cgctccagcg cgagttcctc aaatgttttc ctgcgttgcc aggaccgtcc

181 gccgctctga gtcatgtgcg agtgggaagt cgcactgaca ctgagccggg ccagagggag

241 aggagccgag cgcggcgcgg ggccgaggga ctcgcagtgt gtgtagagag ccgggctcct

301 gcggatgggg gctgcccccg gggcctgagc ccgcctgccc gcccaccgcc ccgccccgcc

361 cctgccaccc ctgccgcccg gttcccatta gcctgtccgc ctctgcggga ccatggagtg

421 gtagccgagg aggaagcatg ctggccgtcg gctgcgcgct gctggctgcc ctgctggccg

481 cgccgggagc ggcgctggcc ccaaggcgct gccctgcgca ggaggtggca agaggcgtgc

541 tgaccagtct gccaggagac agcgtgactc tgacctgccc gggggtagag ccggaagaca

601 atgccactgt tcactgggtg ctcaggaagc cggctgcagg ctcccacccc agcagatggg

661 ctggcatggg aaggaggctg ctgctgaggt cggtgcagct ccacgactct ggaaactatt

721 catgctaccg ggccggccgc ccagctggga ctgtgcactt gctggtggat gttccccccg

781 aggagcccca gctctcctgc ttccggaaga gccccctcag caatgttgtt tgtgagtggg

841 gtcctcggag caccccatcc ctgacgacaa aggctgtgct cttggtgagg aagtttcaga

901 acagtccggc cgaagacttc caggagccgt gccagtattc ccaggagtcc cagaagttct

961 cctgccagtt agcagtcccg gagggagaca gctctttcta catagtgtcc atgtgcgtcg

1021 ccagtagtgt cgggagcaag ttcagcaaaa ctcaaacctt tcagggttgt ggaatcttgc

1081 agcctgatcc gcctgccaac atcacagtca ctgccgtggc cagaaacccc cgctggctca

1141 gtgtcacctg gcaagacccc cactcctgga actcatcttt ctacagacta cggtttgagc

1201 tcagatatcg ggctgaacgg tcaaagacat tcacaacatg gatggtcaag gacctccagc

1261 atcactgtgt catccacgac gcctggagcg gcctgaggca cgtggtgcag cttcgtgccc

1321 aggaggagtt cgggcaaggc gagtggagcg agtggagccc ggaggccatg ggcacgcctt

1381 ggacagaatc caggagtcct ccagctgaga acgaggtgtc cacccccatg caggcactta 1441 ctactaataa agacgatgat aatattctct tcagagattc tgcaaatgcg acaagcctcc 1501 cagtgcaaga ttcttcttca gtaccactgc ccacattcct ggttgctgga gggagcctgg 1561 ccttcggaac gctcctctgc attgccattg ttctgaggtt caagaagacg tggaagctgc 1621 gggctctgaa ggaaggcaag acaagcatgc atccgccgta ctctttgggg cagctggtcc 1681 cggagaggcc tcgacccacc ccagtgcttg ttcctctcat ctccccaccg gtgtccccca 1741 gcagcctggg gtctgacaat acctcgagcc acaaccgacc agatgccagg gacccacgga 1801 gcccttatga catcagcaat acagactact tcttccccag atagctggct gggtggcacc 1861 agcagcctgg accctgtgga tgacaaaaca caaacgggct cagcaaaaga tgcttctcac 1921 tgccatgcca gcttatctca ggggtgtgcg gcctttggct tcacggaaga gccttgcgga 1981 aggttctacg ccaggggaaa atcagcctgc tccagctgtt cagctggttg aggtttcaaa 2041 cctccctttc caaatgccca gcttaaaggg gttagagtga acttgggcca ctgtgaagag 2101 aaccatatca agactctttg gacactcaca cggacactca aaagctgggc aggttggtgg 2161 gggcctcggt gtggagaagc ggctggcagc ccacccctca acacctctgc acaagctgca 2221 ccctcaggca ggtgggatgg atttccagcc aaagcctcct ccagccgcca tgctcctggc 2281 ccactgcatc gtttcatctt ccaactcaaa ctcttaaaac ccaagtgccc ttagcaaatt 2341 ctgtttttct aggcctgggg acggctttta cttaaacgcc aaggcctggg ggaagaagct 2401 ctctcctccc tttcttccct acagttcaaa aacagctgag ggtgagtggg tgaataatac 2461 agtatgtcag ggcctggtcg ttttcaacag aattataatt agttcctcat tagcagtttt 2521 gcctaaatgt gaatgatgat cctaggcatt tgctgaatac agaggcaact gcattggctt 2581 tgggttgcag gacctcaggt gagaagcaga ggaaggagag gagaggggca cagggtctct 2641 accatcccct gtagagtggg agctgagtgg gggatcacag cctctgaaaa ccaatgttct 2701 ctcttctcca cctcccacaa aggagagcta gcagcaggga gggcttctgc catttctgag 2761 atcaaaacgg ttttactgca gctttgtttg ttgtcagctg aacctgggta actagggaag 2821 ataatattaa ggaagacaat gtgaaaagaa aaatgagcct ggcaagaatg cgtttaaact 2881 tggtttttaa aaaactgctg actgttttct cttgagaggg tggaatatcc aatattcgct 2941 gtgtcagcat agaagtaact tacttaggtg tgggggaagc accataactt tgtttagccc 3001 aaaaccaagt caagtgaaaa aggaggaaga gaaaaaatat tttcctgcca ggcatggagg 3061 cccacgcact tcgggaggtc gaggcaggag gatcacttga gtccagaagt ttgagatcag 3121 cctgggcaat gtgataaaac cccatctcta caaaaagcat aaaaattagc caagtgtggt 3181 agagtgtgcc tgaagtccca gatacttggg gggctgaggt gggaggatct cttgagcctg 3241 ggaggtcaag gctgcagtga gccgagattg caccactgca ctccagcctg gggtgacaga 3301 gcaagtgaga ccctgtctc

(2) INFORMATION FOR SEQ ID NO: 118: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1533 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 118: atacctaggc actaatttag ttccatatgt actatgtgta cctgaaaagt tgtgtggcaa

61 tcaaattttc acaaatagaa tcctgtttta aatacactaa gaaagtacct actttatcct

121 ttaaacaaga ggtcagcaga ctttttctac aaagggtcag atagtaaaga ttttacacct

181 tttgtacaat acaatctcta tctcatctac ttagctctgc cattgttgca taaaagcagc

241 tgtagatgat acacaaatgg gtgaggctgt attccaaatg aaacgttatt tgcaaaaaca

301 ggtggtagat taaatttggt cccaaggctt acttgggaaa aaaaaagatc ttttgaaaaa

361 gaaaaaataa atgaataatt tttttaaaaa attgttccct aggtcatagt ttgccagccc

421 ctgccctaaa caaataattc ttgaatgcct actgtggtgt gtaagatatg agtaaatacc

481 agggatacac agagaacaaa agagaaaaac tgctattctt gtgaaacttg gaagttggag

541 gtaagctatt taaaataaac ccacaataaa gtacttcaca tagtgcagac tgtttcttta

601 aatcaaaact cactccaaac aaccaattga ttcactttgt aagtttgaat ttttgtcttc

661 agattctttt aaagtgggcc cttagtcagg agcggtggct catgcctgta gtcctagcac

721 tttgggaggc tgaggcaggc agatcacttg aggtcaggag ttcgagacaa gcctggccaa

781 catggcgaaa ccccgtctcc actgaaaaca caaaaattag gctggcatag tggcatttgc

841 ctgtagtcct agctactcag gaggctgagg caggagaatt gcttgaacct gggaggtgaa

901 aattgcagtg agccgagatc atgctattgt actccagcct gggcaacaaa gcaagactcg

961 tctcaaaaaa ataaaaatta aaaaaataaa gtagcctcta gcctaagata gcttgagcct

1021 aggtgtgaat ctactgcctt actctgatgt aagcacagta agtgtggggg ctgcagggaa

1081 tatccaggag gaacaataat ttcagaggct ctgtctcttc atgtccttga cctctgctta

1141 cagcagcaat acttttactc agacttcctg tttctggaac ttgccttctt ttttgctgtg

1201 tttatacttc ccttgtctgt ggttagataa gtataaagcc ctagatctaa gcttctctgt

1261 cttcctccct ccctcccttc ctcttactct cattcatttc atacacactg gctcacacat

1321 ctactctctc tctctatctc tctcagaatg acaattctag gtacaacttt tggcatggtt

1381 ttttctttac ttcaagtcgt ttctggagaa agtggctatg ctcaaaatgg tgagtcattt

1441 ctaacttttc ttatggattt tggattatct gtagcatggt ttcaggttat tcagttccct

1501 aagagacctg agtcaggcac tgggtttgag tgc

(2) INFORMATION FOR SEQ ID NO: 119: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1658 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 119: ctctctctct atctctctca gaatgacaat tctaggtaca acttttggca tggttttttc 61 tttacttcaa gtcgtttctg gagaaagtgg ctatgctcaa aatggagact tggaagatgc

121 agaactggat gactactcat tctcatgcta tagccagttg gaagtgaatg gatcgcagca

181 ttcactgacc tgtgcttttg aggacccaga tgtcaacacc accaatctgg aatttgaaat

241 atgtggggcc ctcgtggagg taaagtgcct gaatttcagg aaactacaag agatatattt

301 catcgagaca aagaaattct tactgattgg aaagagcaat atatgtgtga aggttggaga

361 aaagagtcta acctgcaaaa aaatagacct aaccactata gttaaacctg aggctccttt

421 tgacctgagt gtcatctatc gggaaggagc caatgacttt gtggtgacat ttaatacatc

481 acacttgcaa aagaagtatg taaaagtttt aatgcatgat gtagcttacc gccaggaaaa

541 ggatgaaaac aaatggacgc atgtgaattt atccagcaca aagctgacac tcctgcagag

601 aaagctccaa ccggcagcaa tgtatgagat taaagttcga tccatccctg atcactattt

661 taaaggcttc tggagtgaat ggagtccaag ttattacttc agaactccag agatcaataa

721 tagctcaggg gagatggatc ctatcttact aaccatcagc attttgagtt ttttctctgt

781 cgctctgttg gtcatcttgg cctgtgtgtt atggaaaaaa aggattaagc ctatcgtatg

841 gcccagtctc cccgatcata agaagactct ggaacatctt tgtaagaaac caagaaaaaa

901 tttaaatgtg agtttcaatc ctgaaagttt cctggactgc cagattcata gggtggatga

961 cattcaagct agagatgaag tggaaggttt tctgcaagat acgtttcctc agcaactaga

1021 agaatctgag aagcagaggc ttggagggga tgtgcagagc cccaactgcc catctgagga

1081 tgtagtcgtc actccagaaa gctttggaag agattcatcc ctcacatgcc tggctgggaa

1141 tgtcagtgca tgtgacgccc ctattctctc ctcttccagg tccctagact gcagggagag

1201 tggcaagaat gggcctcatg tgtaccagga cctcctgctt agccttggga ctacaaacag

1261 cacgctgccc cctccatttt ctctccaatc tggaatcctg acattgaacc cagttgctca

1321 gggtcagccc attcttactt ccctgggatc aaatcaagaa gaagcatatg tcaccatgtc

1381 cagcttctac caaaaccagt gaagtgtaag aaacccagac tgaacttacc gtgagcgaca

1441 aagatgattt aaaagggaag tctagagttc ctagtctccc tcacagcaca gagaagacaa

1501 aattagcaaa accccactac acagtctgca agattctgaa acattgcttt gaccactctt

1561 cctgagttca gtggcactca acatgagtca agagcatcct gcttctacca tgtggatttg

1621 gtcacaaggt ttaaggtgac ccaatgattc agctattt

(2) INFORMATION FOR SEQ ID NO: 120: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3191 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 120: atacctaggc actaatttag ttccatatgt actatgtgta cctgaaaagt tgtgtggcaa

61 tcaaattttc acaaatagaa tcctgtttta aatacactaa gaaagtacct actttatcct

121 ttaaacaaga ggtcagcaga ctttttctac aaagggtcag atagtaaaga ttttacacct

181 tttgtacaat acaatctcta tctcatctac ttagctctgc cattgttgca taaaagcagc

241 tgtagatgat acacaaatgg gtgaggctgt attccaaatg aaacgttatt tgcaaaaaca

301 ggtggtagat taaatttggt cccaaggctt acttgggaaa aaaaaagatc ttttgaaaaa

361 gaaaaaataa atgaataatt tttttaaaaa attgttccct aggtcatagt ttgccagccc

421 ctgccctaaa caaataattc ttgaatgcct actgtggtgt gtaagatatg agtaaatacc

481 agggatacac agagaacaaa agagaaaaac tgctattctt gtgaaacttg gaagttggag

541 gtaagctatt taaaataaac ccacaataaa gtacttcaca tagtgcagac tgtttcttta

601 aatcaaaact cactccaaac aaccaattga ttcactttgt aagtttgaat ttttgtcttc

661 agattctttt aaagtgggcc cttagtcagg agcggtggct catgcctgta gtcctagcac

721 tttgggaggc tgaggcaggc agatcacttg aggtcaggag ttcgagacaa gcctggccaa

781 catggcgaaa ccccgtctcc actgaaaaca caaaaattag gctggcatag tggcatttgc

841 ctgtagtcct agctactcag gaggctgagg caggagaatt gcttgaacct gggaggtgaa

901 aattgcagtg agccgagatc atgctattgt actccagcct gggcaacaaa gcaagactcg

961 tctcaaaaaa ataaaaatta aaaaaataaa gtagcctcta gcctaagata gcttgagcct

1021 aggtgtgaat ctactgcctt actctgatgt aagcacagta agtgtggggg ctgcagggaa

1081 tatccaggag gaacaataat ttcagaggct ctgtctcttc atgtccttga cctctgctta

1141 cagcagcaat acttttactc agacttcctg tttctggaac ttgccttctt ttttgctgtg

1201 tttatacttc ccttgtctgt ggttagataa gtataaagcc ctagatctaa gcttctctgt

1261 cttcctccct ccctcccttc ctcttactct cattcatttc atacacactg gctcacacat

1321 ctactctctc tctctatctc tctcagaatg acaattctag gtacaacttt tggcatggtt

1381 ttttctttac ttcaagtcgt ttctggagaa agtggctatg ctcaaaatgg tgagtcattt

1441 ctaacttttc ttatggattt tggattatct gtagcatggt ttcaggttat tcagttccct

1501 aagagacctg agtcaggcac tgggtttgag tgc ctctctctct atctctctca gaatgacaat tctaggtaca acttttggca tggttttttc

61 tttacttcaa gtcgtttctg gagaaagtgg ctatgctcaa aatggagact tggaagatgc 121 agaactggat gactactcat tctcatgcta tagccagttg gaagtgaatg gatcgcagca 181 ttcactgacc tgtgcttttg aggacccaga tgtcaacacc accaatctgg aatttgaaat 241 atgtggggcc ctcgtggagg taaagtgcct gaatttcagg aaactacaag agatatattt 301 catcgagaca aagaaattct tactgattgg aaagagcaat atatgtgtga aggttggaga 361 aaagagtcta acctgcaaaa aaatagacct aaccactata gttaaacctg aggctccttt 421 tgacctgagt gtcatctatc gggaaggagc caatgacttt gtggtgacat ttaatacatc 481 acacttgcaa aagaagtatg taaaagtttt aatgcatgat gtagcttacc gccaggaaaa 541 ggatgaaaac aaatggacgc atgtgaattt atccagcaca aagctgacac tcctgcagag 601 aaagctccaa ccggcagcaa tgtatgagat taaagttcga tccatccctg atcactattt 661 taaaggcttc tggagtgaat ggagtccaag ttattacttc agaactccag agatcaataa 721 tagctcaggg gagatggatc ctatcttact aaccatcagc attttgagtt ttttctctgt 781 cgctctgttg gtcatcttgg cctgtgtgtt atggaaaaaa aggattaagc ctatcgtatg 841 gcccagtctc cccgatcata agaagactct ggaacatctt tgtaagaaac caagaaaaaa

901 tttaaatgtg agtttcaatc ctgaaagttt cctggactgc cagattcata gggtggatga

961 cattcaagct agagatgaag tggaaggttt tctgcaagat acgtttcctc agcaactaga

1021 agaatctgag aagcagaggc ttggagggga tgtgcagagc cccaactgcc catctgagga

1081 tgtagtcgtc actccagaaa gctttggaag agattcatcc ctcacatgcc tggctgggaa

1141 tgtcagtgca tgtgacgccc ctattctctc ctcttccagg tccctagact gcagggagag

1201 tggcaagaat gggcctcatg tgtaccagga cctcctgctt agccttggga ctacaaacag

1261 cacgctgccc cctccatttt ctctccaatc tggaatcctg acattgaacc cagttgctca

1321 gggtcagccc attcttactt ccctgggatc aaatcaagaa gaagcatatg tcaccatgtc

1381 cagcttctac caaaaccagt gaagtgtaag aaacccagac tgaacttacc gtgagcgaca

1441 aagatgattt aaaagggaag tctagagttc ctagtctccc tcacagcaca gagaagacaa

1501 aattagcaaa accccactac acagtctgca agattctgaa acattgcttt gaccactctt

1561 cctgagttca gtggcactca acatgagtca agagcatcct gcttctacca tgtggatttg

1621 gtcacaaggt ttaaggtgac ccaatgattc agctattt

(2) INFORMATION FOR SEQ ID NO:121: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1846 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO :121: ctcagcctcg ctatggctcc cagcagcccc cggcccgcgc tgcccgcact cctggtcctg

61 ctcggggctc tgttcccagg acctggcaat gcccagacat ctgtgtcccc ctcaaaagtc

121 atcctgcccc ggggaggctc cgtgctggtg acatgcagca cctcctgtga ccagcccaag

181 ttgttgggca tagagacccc gttgcctaaa aaggagttgc tcctgcctgg gaacaaccgg

241 aaggtgtatg aactgagcaa tgtgcaagaa gatagccaac caatgtgcta ttcaaactgc

301 cctgatgggc agtcaacagc taaaaccttc ctcaccgtgt actggactcc agaacgggtg

361 gaactggcac ccctcccctc ttggcagcca gtgggcaaga accttaccct acgctgccag

421 gtggagggtg gggcaccccg ggccaacctc accgtggtgc tgctccgtgg ggagaaggag

481 ctgaaacggg agccagctgt gggggagccc gctgaggtca cgaccacggt gctggtgagg

541 agagatcacc atggagccaa tttctcgtgc cgcactgaac tggacctgcg gccccaaggg

601 ctggagctgt ttgagaacac ctcggccccc taccagctcc agacctttgt cctgccagcg

661 actcccccac aacttgtcag cccccgggtc ctagaggtgg acacgcaggg gaccgtggtc

721 tgttccctgg acgggctgtt cccagtctcg gaggcccagg tccacctggc actgggggac

781 cagaggttga accccacagt cacctatggc aacgactcct tctcggccaa ggcctcagtc

841 agtgtgaccg cagaggacga gggcacccag cggctgacgt gtgcagtaat actggggaac

901 cagagccagg agacactgca gacagtgacc atctacagct ttccggcgcc caacgtgatt

961 ctgacgaagc cagaggtctc agaagggacc gaggtgacag tgaagtgtga ggcccaccct

1021 agagccaagg tgacgctgaa tggggttcca gcccagccac tgggcccgag ggcccagctc

1081 ctgctgaagg ccaccccaga ggacaacggg cgcagcttct cctgctctgc aaccctggag

1141 gtggccggcc agcttataca caagaaccag acccgggagc ttcgtgtcct gtatggcccc

1201 cgactggacg agagggattg tccgggaaac tggacgtggc cagaaaattc ccagcagact

1261 ccaatgtgcc aggcttgggg gaacccattg cccgagctca agtgtctaaa ggatggcact

1321 ttcccactgc ccatcgggga atcagtgact gtcactcgag atcttgaggg cacctacctc

1381 tgtcgggcca ggagcactca aggggaggtc acccgcgagg tgaccgtgaa tgtgctctcc

1441 ccccggtatg agattgtcat catcactgtg gtagcagccg cagtcataat gggcactgca

1501 ggcctcagca cgtacctcta taaccgccag cggaagatca agaaatacag actacaacag

1561 gcccaaaaag ggacccccat gaaaccgaac acacaagcca cgcctccctg aacctatccc

1621 gggacagggc ctcttcctcg gccttcccat attggtggca gtggtgccac actgaacaga

1681 gtggaagaca tatgccatgc agctacacct accggccctg ggacgccgga ggacagggca

1741 ttgtcctcag tcagatacaa cagcatttgg ggccatggta cctgcacacc taaaacacta

1801 ggccacgcat ctgatctgta gtcacatgac taagccaaga ggaagg

(2) INFORMATION FOR SEQ ID NO: 122: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1041 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 122: ctaaagatct ccctccaggc agcccttggc tggtccctgc gagcccgtgg agactgccag

61 agatgtcctc tttcggttac aggaccctga ctgtggccct cttcaccctg atctgctgtc

121 caggatcgga tgagaaggta ttcgaggtac acgtgaggcc aaagaagctg gcggttgagc

181 ccaaagggtc cctcgaggtc aactgcagca ccacctgtaa ccagcctgaa gtgggtggtc

241 tggagacctc tctaaataag attctgctgg acgaacaggc tcagtggaaa cattacttgg

301 tctcaaacat ctcccatgac acggtcctcc aatgccactt cacctgctcc gggaagcagg

361 agtcaatgaa ttccaacgtc agcgtgtacc agcctccaag gcaggtcatc ctgacactgc

421 aacccacttt ggtggctgtg ggcaagtcct tcaccattga gtgcagggtg cccaccgtgg

481 agcccctgga cagcctcacc ctcttcctgt tccgtggcaa tgagactctg cactatgaga

541 ccttcgggaa ggcagcccct gctccgcagg aggccacagc cacattcaac agcacggctg

601 acagagagga tggccaccgc aacttctcct gcctggctgt gctggacttg atgtctcgcg

661 gtggcaacat ctttcacaaa cactcagccc cgaagatgtt ggagatctat gagcctgtgt

721 cggacagcca gatggtcatc atagtcacgg tggtgtcggt gttgctgtcc ctgttcgtga

781 catctgtcct gctctgcttc atcttcggcc agcacttgcg ccagcagcgg atgggcacct 841 acggggtgcg agcggcttgg aggaggctgc cccaggcctt ccggccatag caaccatgag

901 tggcatggcc accaccacgg tggtcactgg aactcagtgt gactcctcag ggttgaggtc

961 cagccctggc tgaaggactg tgacaggcag cagagacttg ggacattgcc ttttctagcc 1021 cgaatacaaa cacctggact t

(2) INFORMATION FOR SEQ ID NO: 123: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2887 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 123: ctcagcctcg ctatggctcc cagcagcccc cggcccgcgc tgcccgcact cctggtcctg

61 ctcggggctc tgttcccagg acctggcaat gcccagacat ctgtgtcccc ctcaaaagtc

121 atcctgcccc ggggaggctc cgtgctggtg acatgcagca cctcctgtga ccagcccaag

181 ttgttgggca tagagacccc gttgcctaaa aaggagttgc tcctgcctgg gaacaaccgg

241 aaggtgtatg aactgagcaa tgtgcaagaa gatagccaac caatgtgcta ttcaaactgc

301 cctgatgggc agtcaacagc taaaaccttc ctcaccgtgt actggactcc agaacgggtg

361 gaactggcac ccctcccctc ttggcagcca gtgggcaaga accttaccct acgctgccag

421 gtggagggtg gggcaccccg ggccaacctc accgtggtgc tgctccgtgg ggagaaggag

481 ctgaaacggg agccagctgt gggggagccc gctgaggtca cgaccacggt gctggtgagg

541 agagatcacc atggagccaa tttctcgtgc cgcactgaac tggacctgcg gccccaaggg

601 ctggagctgt ttgagaacac ctcggccccc taccagctcc agacctttgt cctgccagcg

661 actcccccac aacttgtcag cccccgggtc ctagaggtgg acacgcaggg gaccgtggtc

721 tgttccctgg acgggctgtt cccagtctcg gaggcccagg tccacctggc actgggggac

781 cagaggttga accccacagt cacctatggc aacgactcct tctcggccaa ggcctcagtc

841 agtgtgaccg cagaggacga gggcacccag cggctgacgt gtgcagtaat actggggaac

901 cagagccagg agacactgca gacagtgacc atctacagct ttccggcgcc caacgtgatt

961 ctgacgaagc cagaggtctc agaagggacc gaggtgacag tgaagtgtga ggcccaccct

1021 agagccaagg tgacgctgaa tggggttcca gcccagccac tgggcccgag ggcccagctc

1081 ctgctgaagg ccaccccaga ggacaacggg cgcagcttct cctgctctgc aaccctggag

1141 gtggccggcc agcttataca caagaaccag acccgggagc ttcgtgtcct gtatggcccc

1201 cgactggacg agagggattg tccgggaaac tggacgtggc cagaaaattc ccagcagact

1261 ccaatgtgcc aggcttgggg gaacccattg cccgagctca agtgtctaaa ggatggcact

1321 ttcccactgc ccatcgggga atcagtgact gtcactcgag atcttgaggg cacctacctc

1381 tgtcgggcca ggagcactca aggggaggtc acccgcgagg tgaccgtgaa tgtgctctcc

1441 ccccggtatg agattgtcat catcactgtg gtagcagccg cagtcataat gggcactgca

1501 ggcctcagca cgtacctcta taaccgccag cggaagatca agaaatacag actacaacag

1561 gcccaaaaag ggacccccat gaaaccgaac acacaagcca cgcctccctg aacctatccc

1621 gggacagggc ctcttcctcg gccttcccat attggtggca gtggtgccac actgaacaga

1681 gtggaagaca tatgccatgc agctacacct accggccctg ggacgccgga ggacagggca

1741 ttgtcctcag tcagatacaa cagcatttgg ggccatggta cctgcacacc taaaacacta

1801 ggccacgcat ctgatctgta gtcacatgac taagccaaga ggaagg ctaaagatct ccctccaggc agcccttggc tggtccctgc gagcccgtgg agactgccag

61 agatgtcctc tttcggttac aggaccctga ctgtggccct cttcaccctg atctgctgtc

121 caggatcgga tgagaaggta ttcgaggtac acgtgaggcc aaagaagctg gcggttgagc

181 ccaaagggtc cctcgaggtc aactgcagca ccacctgtaa ccagcctgaa gtgggtggtc

241 tggagacctc tctaaataag attctgctgg acgaacaggc tcagtggaaa cattacttgg

301 tctcaaacat ctcccatgac acggtcctcc aatgccactt cacctgctcc gggaagcagg

361 agtcaatgaa ttccaacgtc agcgtgtacc agcctccaag gcaggtcatc ctgacactgc

421 aacccacttt ggtggctgtg ggcaagtcct tcaccattga gtgcagggtg cccaccgtgg

481 agcccctgga cagcctcacc ctcttcctgt tccgtggcaa tgagactctg cactatgaga

541 ccttcgggaa ggcagcccct gctccgcagg aggccacagc cacattcaac agcacggctg

601 acagagagga tggccaccgc aacttctcct gcctggctgt gctggacttg atgtctcgcg

661 gtggcaacat ctttcacaaa cactcagccc cgaagatgtt ggagatctat gagcctgtgt

721 cggacagcca gatggtcatc atagtcacgg tggtgtcggt gttgctgtcc ctgttcgtga

781 catctgtcct gctctgcttc atcttcggcc agcacttgcg ccagcagcgg atgggcacct

841 acggggtgcg agcggcttgg aggaggctgc cccaggcctt ccggccatag caaccatgag

901 tggcatggcc accaccacgg tggtcactgg aactcagtgt gactcctcag ggttgaggtc

961 cagccctggc tgaaggactg tgacaggcag cagagacttg ggacattgcc ttttctagcc 1021 cgaatacaaa cacctggact t

(2) INFORMATION FOR SEQ ID NO: 124: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1739 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 124: aatggccacc atggtaccat ccgtgttgtg gcccagggcc tgctggactc tgctggtctg

61 ctgtctgctg accccaggtg tccaggggca ggagttcctt ttgcgggtgg agccccagaa

121 ccctgtgctc tctgctggag ggtccctgtt tgtgaactgc agtactgatt gtcccagctt

181 tgagaaaatc gccttggaga cgtccctatc aaaggagctg gtggccagtg gcatgggctg

241 ggcagccttc aatctcagca acgtgactgg caacagtcgg atcctctgct cagtgtactg

301 caatggctcc cagataacag gctcctctaa catcaccgtg tacgggctcc cggagcgtgt 361 ggagctggca cccctgcctc cttggcagcc ggtgggccag aacttcaccc tgcgctgcca

421 agtggagggt gggtcgcccc ggaccagcct cacggtggtg ctgcttcgct gggaggagga

481 gctgagccgg cagcccgcag tggaggagcc agcggaggtc actgccactg tgctggccag

541 cagagacgac cacggagccc ctttctcatg ccgcacagaa ctggacatgc agccccaggg

601 gctgggactg ttcgtgaaca cctcagcccc ccgccagctc cgaacctttg tcctgcccgt

661 gacccccccg cgcctcgtgg ccccccggtt cttggaggtg gaaacgtcgt ggccggtgga

721 ctgcacccta gacgggcttt ttccagcctc agaggcccag gtctacctgg cgctggggga

781 ccagatgctg aatgcgacag tcatgaacca cggggacacg ctaacggcca cagccacagc

841 cacggcgcgc gcggatcagg agggtgcccg ggagatcgtc tgcaacgtga ccctaggggg

901 cgagagacgg gaggcccggg agaacttgac ggtctttagc ttcctaggac ccattgtgaa

961 cctcagcgag cccaccgccc atgaggggtc cacagtgacc gtgagttgca tggctggggc

1021 tcgagtccag gtcacgctgg acggagttcc ggccgcggcc ccggggcagc cagctcaact

1081 tcagctaaat gctaccgaga gtgacgacgg acgcagcttc ttctgcagtg ccactctcga

1141 ggtggacggc gagttcttgc acaggaacag tagcgtccag ctgcgagtcc tgtatggtcc

1201 caaaattgac cgagccacat gcccccagca cttgaaatgg aaagataaaa cgagacacgt

1261 gctgcagtgc caagccaggg gcaacccgta ccccgagctg cggtgtttga aggaaggctc

1321 cagccgggag gtgccggtgg ggatcccgtt cttcgtcaac gtaacacata atggtactta

1381 tcagtgccaa gcgtccagct cacgaggcaa atacaccctg gtcgtggtga tggacattga

1441 ggctgggagc tcccactttg tccccgtctt cgtggcggtg ttactgaccc tgggcgtggt

1501 gactatcgta ctggccttaa tgtacgtctt cagggagcac caacggagcg gcagttacca

1561 tgttagggag gagagcacct atctgcccct cacgtctatg cagccgacag aagcaatggg

1621 ggaagaaccg tccagagctg agtgacgctg ggatccggga tcaaagttgg cgggggcttg

1681 gctgtgccct cagattccgc accaataaag ccttcaaacc ctaaaaaaaa aaaaaaaaa

(2) INFORMATION FOR SEQ ID NO: 125: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 920 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xι)SEQUENCE DESCRIPTION: SEQ ID NO:125: gcacggaggg gcagagaccc cggagcccca gccccaccat gaccctcggc cgccgactcg

61 cgtgtctttt cctcgcctgt gtcctgccgg ccttgctgct ggggggcacc gcgctggcct

121 cggagattgt ggggggccgg cgagcgcggc cccacgcgtg gcccttcatg gtgtccctgc

181 agctgcgcgg aggccacttc tgcggcgcca ccctgattgc gcccaacttc gtcatgtcgg

241 ccgcgcactg cgtggcgaat gtaaacgtcc gcgcggtgcg ggtggtcctg ggagcccata

301 acctctcgcg gcgggagccc acccggcagg tgttcgccgt gcagcgcatc ttcgaaaacg

361 gctacgaccc cgtaaacttg ctcaacgaca tcgtgattct ccagctcaac gggtcggcca

421 ccatcaacgc caacgtgcag gtggcccagc tgccggctca gggacgccgc ctgggcaacg

481 gggtgcagtg cctggccatg ggctggggcc ttctgggcag gaaccgtggg atcgccagcg

541 tcctgcagga gctcaacgtg acggtggtga cgtccctctg ccgtcgcagc aacgtctgca

601 ctctcgtgag gggccggcag gccggcgtct gtttcgggga ctccggcagc cccttggtct

661 gcaacgggct aatccacgga attgcctcct tcgtccgggg aggctgcgcc tcagggctct

721 accccgatgc ctttgccccg gtggcacagt ttgtaaactg gatcgactct atcatccaac

781 gctccgagga caacccctgt ccccaccccc gggacccgga cccggccagc aggacccact

841 gagaagggct gcccgggtca cctcagctgc ccacacccac actctccagc atctggcaca

901 ataaacattc tctgttttgt

(2) INFORMATION FOR SEQ ID NO: 126: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 5292 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 126: ttgtcagagc cccagctggt gtccagggac tgaccgtgag cctgggtgaa agtgagttcc

61 ccgttggagg caccagacga ggagaggatg gaaggcctgg cccccaagaa tgagccctga 121 ggttcaggag cggctggagt gagccgcccc cagatctccg tccagctgcg ggtcccagag 181 gcctgggtta cactcggagc tcctggggga ggcccttgac gtgctcagtt cccaaacagg 241 aaccctggga aggaccagag aagtgcctat tgcgcagtga gtgcccgaca cagctgcatg 301 tggccggtat cacagggccc tgggtaaact gaggcaggcg acacagctgc atgtggccgg 361 tatcacaggg ccctgggtaa actgaggcag gcgacacagc tgcatgtggc cggtatcaca 421 gggccctggg taaactgagg caggcgacac agctgcatgt ggccggtatc acagggccct 481 gggtaaactg aggcaggcga cacagctgca tgtggccggt atcacggggc cctggataaa 541 cagaggcagg cgaggccacc cccatcaagt ccctcaggtc taggtttggc caggtttgga 601 aaaacacagc aacgctcggt aaatctgaat ttcgggtaag tatatcctgg gcctcatttg 661 gaagagactt agattaaaaa aaaaacgtcg agaccagccc ggccaacacg tgaaaccccg 721 tctctactaa aaatacaaaa aattagccag gcgcagtgct cacgcctgtg atcccagcac 781 tctgggaggt gaggcaggcg gatcacccga ggtcagctgt tcaagaccag cctggccgag 841 tgggcgaaac actgtctcta ctacaaatac aaaaattagc cgggagtgga ggcaggtgcc 901 tgtaatctca gctattcagg aggctgaggc aggagaatca cttgaacctg ggaggcggag 961 gttgccgtga gccgggatca cgccaccgca ctccagcctg ggcgatagag caagactctg 1021 tctccaaaaa aataaattaa aaaacccaca ttgattatct gacatttgaa tgcgattgtg 1081 catcctgaat tttgtctgga ggccccaccc gagccaatcc agcgtcttgt cccccttctc 1141 ccccttttca tcaacgcctg tgccagggga gaggaagtgg agggcgctgg ccggccgtgg 1201 ggcaatgcaa cggcctccca gcacagggct ataagaggag ccgggcgggc acggaggggc 1261 agagaccccg gagccccagc cccaccatga ccctcggccg ccgactcgcg tgtcttttcc 1321 tcgcctgtqt cctgccggcc ttgctgctgςj ggggtgagtt ^g^gtcca acςtcccgct 1381 gctcfefitctg tcdSg'g.gt c ijttc δiά' 'ci tc fcaCaga gfgςieςcacc θgSα£ gg c; 1441 cc'tcatcctS a'caggggagg tgccagctgg gacaaggaga ccagaagaga' ctgaggttct 1501 gagcggtgaa gccaccacca ggagcccgga gttggggttt gaaaaccggg gagggggggg 1561 gtggcaggtc gcςctctggg ttcaagtcca ggtctgtctg tgccttggag gggcaccgtg 1621 gggaggtccc tttgcςtcζc cgtgcctcag tttcctcatc tgaac^acag gggtgcgaac 1681 ggccccgatc ccgt;gggttc ccggtggggg atccagaggc cccgtggccg ggaggggaca 1741 ggctccttgg gtggcactca gcacccgcac cςggtgtgtc cccg.ggc§cc gcgctggςct 1801 cggagattg^"t ggggggςcgg cgagcgcggc cccacgcgtg gcccttcatg gtgtccctgc 1861 agctgcgcgg aggccacttc tgcggcgcca ccctgattgc gcccaacttc gtcatgtcgg 1921 ccgcgcactg cgtggcgaat gtgtgagtag ccgggagtgt gcgcgcccgg ctcggacccc 1981 gcgtcccggt ctgtgaggtg ggtgggggga ggccggggcc ggggctgctg gcgggggggg 2041 gtccgtccag ggcccgcggg gcccctcgag caccttcgcc ctcaggcccg tcgccggatg 2101 gggacgacaa ggcgcggctg agccccgacc cccggggccg cccctgagcc ccgcctctcc 2161 ctcttttggc agaaacgtcc gcgcggtgcg ggtggtcctg ggagcccata acctctcgcg 2221 gcgggagccc acccggcagg tgttcgccgt gcagcgcatc ttcgaaaacg gctacgaccc 2281 cgtaaacttg ctcaacgaca tcgtgattct ccaggtgccg ccgggcgggc gggggcgagg 2341 ggcggaggcc agaggcctgg ggagggtgga ggcctgggga gggtggaggc tgcgacggag 2401 gggcgcgtcg gggccgctcg tggggacctg gggtggcatc gtgggctggg tggtcccctc 2461 tccgcgcctc ggtctgcacc tctgtgaaac gggaaaatac ccgccatggg ccgttgaggg 2521 gttaaatgag atcctgcagg gaggccccga tctgctgtca atcaacaaac ttactgagaa 2581 gggaggcccc gatctgttgt caatcaacaa acttactgag aagggaggcc ccgatctgtt 2641 gtcaatcaac aaacttactg agaagggagg ccccgatctg ctgtcaatca acaaacttac 2701 tgagaaggga ggccccgatg ttgtcaatca acaaacttac tgagaaggga ggccccgatc 2761 tgctgtcaat caaccaaact tactgagaag ggaggccccg atctgctgtc aatcatcaaa 2821 cttactgaga agggaggccc cgatctgctg tcaatcaaca aacttactga gaagggaggc 2881 ccccgatctg ttgtcaatca acaaacttac tgagaaggga ggccccgatc tgctgtcaat 2941 caacaaactt actgagattc tgtgtgtctc tccattcacc agtcctgtgg cccagggcag 3001 gggccgcctc tgtctttggg aaaaggggca aaagtcccca cctttccacc cctgtccgcg 3061 gcttgcagtt ctggttattt cctgggcgcc gggccccgtg gctcaggcct gtcatcccag 3121 cactttggga ggctgaggcg ggtggatcac gaggtcaggt gttcgagacc agcctgagca 3181 acatagtgaa accccgtctc tactaaaata cacaaaaaaa aaattagccg agtgtggttg 3241 tgggtgcctg taatgccaac tactcaggag gctgaggaag gagaatcgct tgaaccccgg 3301 aggcggagat tgcagtgagc tgagatcaca ccactgcact ccagcctggg tctcaaaaaa 3361 aaaaaaaaag attcctccct gggaagggtt agagggagag tttccttgtc actaagtttt 3421 ctcatagctc tcacccagtg cagtggcgcg atcgcagctc actacacctc catctcctgg 3481 gctcaagcca ccctctcagc ttggaatggg gggtagctgg aaccacaggt gccaccacgt 3541 ggtccaccac gtctggctaa tatatatata tacacacaca catacatata ttataaataa 3601 taaatatata ttttatttaa ataaaatata taatatttat aattatttta taattataat 3661 aatatttata taattataaa tatcatttat aattataata tttattattt tataaaataa 3721 taaatataaa atatataaaa atatttttat aaataataaa atatatatat acacacatat 3781 atatatattt tttgagacaa gtctcgctct gtcgcccagg ctggagcgca gtgcacaatc 3841 tcactcactg cacctccgcc tcccaggttc aagcgattct cctgcctcag cctcccaggt 3901 agctgggact acaggcgccc gccaccacgc ctggctaatt tttggtattg ttagtagaga 3961 cggggtttaa ccatgttagc caggatggtc ttgatctcct gaccttttga ttggcccacc 4021 tcagcctccc aaaatgctgg gattataggc gtgagcaccg cacctggcaa ttttttttta 4081 ttatttttgt agacatgggg ctttgccaca ttgcccaggc tggtcttgaa tgcctggcct 4141 ggcctaagtg atcctcctgc ctcgccctcc caaagtgctg ggcttacaag catgagccac 4201 cgcgcccggc tgtagttttt ttgttaactg agcacctact gcttcctgca ctcaagccac 4261 atccagggac aacctccaac gccctgagcc ttggtgacgg ctcccactct acagatgggg 4321 aaaccgaggc ttgccttggg gagcagagtg tggggtgggt atcctgccct gcaggatccc 4381 agaaccacag tggaacctga gatggggaaa ctgaggcccg gagaggggag ggtcatcatc 4441 actgccccgt gtgacgcgct gacgatctgt ccccaccgcc acagctcaac gggtcggcca 4501 ccatcaacgc caacgtgcag gtggcccagc tgccggctca gggacgccgc ctgggcaacg 4561 gggtgcagtg cctggccatg ggctggggcc ttctgggcag gaaccgtggg atcgccagcg 4621 tcctgcagga gctcaacgtg acggtggtga cgtccctctg ccgtcgcagc aacgtctgca 4681 ctctcgtgag gggccggcag gccggcgtct gtttcgtacg tgccctgggt gtccctctgc 4741 tccccacccg ctcccagccc ggtactgcag caacaggcac cgtggctaga ccctaggatg 4801 ggacttccca accctgacac gtcggcgggc aggtgggcag ggcctcgcag tccagcttcc 4861 ccaccttgtc tgcctccaca gggggactcc ggcagcccct tggtctgcaa cgggctaatc 4921 cacggaattg cctccttcgt ccggggaggc tgcgcctcag ggctctaccc cgatgccttt 4981 gccccggtgg cacagtttgt aaactggatc gactctatca tccaacgctc cgaggacaac 5041 ccctgtcccc acccccggga cccggacccg gccagcagga cccactgaga agggctgccc 5101 gggtcacctc agctgcccac acccacactc tccagcatct ggcacaataa acattctctg 5161 ttttgtagaa tgtgtttgat gctccttggc tgtgtgattg ggtgttgaaa atggtcagta 5221 ggtcgggcgt ggtggctcac acctgtaatc ccagcacttt gggaggttga ggcaggcgga 5281 tcacttgagc tc

INFORMATION FOR SEQ ID NO: 127: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 6212 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 127: gcacggaggg gcagagaccc cggagcccca gccccaccat gaccctcggc cgccgactcg

61 cgtgtctttt cctcgcctgt gtcctgccgg ccttgctgct ggggggcacc gcgctggcct 121 cggagattgt ggggggccgg cgagcgcggc cccacgcgtg gcccttcatg gtgtccctgc 181 agctgcgcgg aggccacttc tgcggcgcca ccctgattgc gcccaacttc gtcatgtcgg 241 ccgcgcactg cgtggcgaat gtaaacgtcc gcgcggtgcg ggtggtcctg ggagcccata 301 acctctcgcg gcgggagccc acccggcagg tgttcgccgt gcagcgcatc ttcgaaaacg 361 gctacgaccc cgtaaacttg ctcaacgaca tcgtgattct ccagctcaac gggtcggcca 421 ccatcaacgc caacgtgcag gtggcccagc tgccggctca gggacgccgc ctgggcaacg 481 gggtgcagtg cctggccatg ggctggggcc ttctgggcag gaaccgtggg atcgccagcg 541 tcctgcagga gctcaacgtg acggtggtga cgtccctctg ccgtcgcagc aacgtctgca 601 ctctcgtgag gggccggcag gccggcgtct gtttcgggga ctccggcagc cccttggtct 661 gcaacgggct aatccacgga attgcctcct tcgtccgggg aggctgcgcc tcagggctct 721 accccgatgc ctttgccccg gtggcacagt ttgtaaactg gatcgactct atcatccaac 781 gctccgagga caacccctgt ccccaccccc gggacccgga cccggccagc aggacccact 841 gagaagggct gcccgggtca cctcagctgc ccacacccac actctccagc atctggcaca 901 ataaacattc tctgttttgt ttgtcagagc cccagctggt gtccagggac tgaccgtgag cctgggtgaa agtgagttcc

61 ccgttggagg caccagacga ggagaggatg gaaggcctgg cccccaagaa tgagccctga

121 ggttcaggag cggctggagt gagccgcccc cagatctccg tccagctgcg ggtcccagag

181 gcctgggtta cactcggagc tcctggggga ggcccttgac gtgctcagtt cccaaacagg

241 aaccctggga aggaccagag aagtgcctat tgcgcagtga gtgcccgaca cagctgcatg

301 tggccggtat cacagggccc tgggtaaact gaggcaggcg acacagctgc atgtggccgg

361 tatcacaggg ccctgggtaa actgaggcag gcgacacagc tgcatgtggc cggtatcaca

421 gggccctggg taaactgagg caggcgacac agctgcatgt ggccggtatc acagggccct

481 gggtaaactg aggcaggcga cacagctgca tgtggccggt atcacggggc cctggataaa

541 cagaggcagg cgaggccacc cccatcaagt ccctcaggtc taggtttggc caggtttgga

601 aaaacacagc aacgctcggt aaatctgaat ttcgggtaag tatatcctgg gcctcatttg

661 gaagagactt agattaaaaa aaaaacgtcg agaccagccc ggccaacacg tgaaaccccg

721 tctctactaa aaatacaaaa aattagccag gcgcagtgct cacgcctgtg atcccagcac

781 tctgggaggt gaggcaggcg gatcacccga ggtcagctgt tcaagaccag cctggccgag

841 tgggcgaaac actgtctcta ctacaaatac aaaaattagc cgggagtgga ggcaggtgcc

901 tgtaatctca gctattcagg aggctgaggc aggagaatca cttgaacctg ggaggcggag

961 gttgccgtga gccgggatca cgccaccgca ctccagcctg ggcgatagag caagactctg

1021 tctccaaaaa aataaattaa aaaacccaca ttgattatct gacatttgaa tgcgattgtg

1081 catcctgaat tttgtctgga ggccccaccc gagccaatcc agcgtcttgt cccccttctc

1141 ccccttttca tcaacgcctg tgccagggga gaggaagtgg agggcgctgg ccggccgtgg

1201 ggcaatgcaa cggcctccca gcacagggct ataagaggag ccgggcgggc acggaggggc

1261 agagaccccg gagccccagc cccaccatga ccctcggccg ccgactcgcg tgtcttttcc

1321 tcgcctgtgt cctgccggcc ttgctgctgg ggggtgagtt tttgagtcca acctcccgct

1381 gctccctctg tcccgggttc tgttcccacc tctccataga gggccccacc agtgtgggtc

1441 cctcatcctc acaggggagg tgccagctgg gacaaggaga ccagaagaga ctgaggttct

1501 gagcggtgaa gccaccacca ggagcccaga gttggggttt gaaaaccggg gagggggggg

1561 gtggcaggtc gccctctggg ttcaagtcca ggtctgtctg tgccttggag gggcaccgtg

1621 gggaggtccc tttgcctctc cgtgcctcag tttcctcatc tgaacaacag gggtgcgaac

1681 ggccccgatc ccgtgggttc ccggtggggg atccagaggc cccgtggccg ggaggggaca

1741 ggctccttgg caggcactca gcacccgcac ccggtgtgtc cccaggcacc gcgctggcct

1801 cggagattgt ggggggccgg cgagcgcggc cccacgcgtg gcccttcatg gtgtccctgc

1861 agctgcgcgg aggccacttc tgcggcgcca ccctgattgc gcccaacttc gtcatgtcgg

1921 ccgcgcactg cgtggcgaat gtgtgagtag ccgggagtgt gcgcgcccgg ctcggacccc

1981 gcgtcccggt ctgtgaggtg ggtgggggga ggccggggcc ggggctgctg gcgggggggg

2041 gtccgtccag ggcccgcggg gcccctcgag caccttcgcc ctcaggcccg tcgccggatg

2101 gggacgacaa ggcgcggctg agccccgacc cccggggccg cccctgagcc ccgcctctcc

2161 ctcttttggc agaaacgtcc gcgcggtgcg ggtggtcctg ggagcccata acctctcgcg

2221 gcgggagccc acccggcagg tgttcgccgt gcagcgcatc ttcgaaaacg gctacgaccc

2281 cgtaaacttg ctcaacgaca tcgtgattct ccaggtgccg ccgggcgggc gggggcgagg

2341 ggcggaggcc agaggcctgg ggagggtgga ggcctgggga gggtggaggc tgcgacggag

2401 gggcgcgtcg gggccgctcg tggggacctg gggtggcatc gtgggctggg tggtcccctc

2461 tccgcgcctc ggtctgcacc tctgtgaaac gggaaaatac ccgccatggg ccgttgaggg

2521 gttaaatgag atcctgcagg gaggccccga tctgctgtca atcaacaaac ttactgagaa

2581 gggaggcccc gatctgttgt caatcaacaa acttactgag aagggaggcc ccgatctgtt

2641 gtcaatcaac aaacttactg agaagggagg ccccgatctg ctgtcaatca acaaacttac

2701 tgagaaggga ggccccgatg ttgtcaatca acaaacttac tgagaaggga ggccccgatc

2761 tgctgtcaat caaccaaact tactgagaag ggaggccccg atctgctgtc aatcatcaaa

2821 cttactgaga agggaggccc cgatctgctg tcaatcaaca aacttactga gaagggaggc

2881 ccccgatctg ttgtcaatca acaaacttac tgagaaggga ggccccgatc tgctgtcaat

2941 caacaaactt actgagattc tgtgtgtctc tccattcacc agtcctgtgg cccagggcag

3001 gggccgcctc tgtctttggg aaaaggggca aaagtcccca cctttccacc cctgtccgcg

3061 gcttgcagtt ctggttattt cctgggcgcc gggccccgtg gctcaggcct gtcatcccag

3121 cactttggga ggctgaggcg ggtggatcac gaggtcaggt gttcgagacc agcctgagca

3181 acatagtgaa accccgtctc tactaaaata cacaaaaaaa aaattagccg agtgtggttg

3241 tgggtgcctg taatgccaac tactcaggag gctgaggaag gagaatcgct tgaaccccgg

3301 aggcggagat tgcagtgagc tgagatcaca ccactgcact ccagcctggg tctcaaaaaa

3361 aaaaaaaaag attcctccct gggaagggtt agagggagag tttccttgtc actaagtttt 3421 ctcatagctc tcacccagtg cagtggcgcg atcgcagctc actacacctc catctcctgg 3481 gctcaagcca ccctctcagc ttggaatggg gggtagctgg aaccacaggt gccaccacgt 3541 ggtccaccac gtctggctaa tatatatata tacacacaca catacatata ttataaataa 3601 taaatatata ttttatttaa ataaaatata taatatttat aattatttta taattataat 3661 aatatttata taattataaa tatcatttat aattataata tttattattt tataaaataa 3721 taaatataaa atatataaaa atatttttat aaataataaa atatatatat acacacatat 3781 atatatattt tttgagacaa gtctcgctct gtcgcccagg ctggagcgca gtgcacaatc 3841 tcactcactg cacctccgcc tcccaggttc aagcgattct cctgcctcag cctcccaggt 3901 agctgggact acaggcgccc gccaccacgc ctggctaatt tttggtattg ttagtagaga 3961 cggggtttaa ccatgttagc caggatggtc ttgatctcct gaccttttga ttggcccacc 4021 tcagcctccc aaaatgctgg gattataggc gtgagcaccg cacctggcaa ttttttttta 4081 ttatttttgt agacatgggg ctttgccaca ttgcccaggc tggtcttgaa tgcctggcct 4141 ggcctaagtg atcctcctgc ctcgccctcc caaagtgctg ggcttacaag catgagccac 4201 cgcgcccggc tgtagttttt ttgttaactg agcacctact gcttcctgca ctcaagccac 4261 atccagggac aacctccaac gccctgagcc ttggtgacgg ctcccactct acagatgggg 4321 aaaccgaggc ttgccttggg gagcagagtg tggggtgggt atcctgccct gcaggatccc 4381 agaaccacag tggaacctga gatggggaaa ctgaggcccg gagaggggag ggtcatcatc 4441 actgccccgt gtgacgcgct gacgatctgt ccccaccgcc acagctcaac gggtcggcca 4501 ccatcaacgc caacgtgcag gtggcccagc tgccggctca gggacgccgc ctgggcaacg 4561 gggtgcagtg cctggccatg ggctggggcc ttctgggcag gaaccgtggg atcgccagcg 4621 tcctgcagga gctcaacgtg acggtggtga cgtccctctg ccgtcgcagc aacgtctgca 4681 ctctcgtgag gggccggcag gccggcgtct gtttcgtacg tgccctgggt gtccctctgc 4741 tccccacccg ctcccagccc ggtactgcag caacaggcac cgtggctaga ccctaggatg 4801 ggacttccca accctgacac gtcggcgggc aggtgggcag ggcctcgcag tccagcttcc 4861 ccaccttgtc tgcctccaca gggggactcc ggcagcccct tggtctgcaa cgggctaatc 4921 cacggaattg cctccttcgt ccggggaggc tgcgcctcag ggctctaccc cgatgccttt 4981 gccccggtgg cacagtttgt aaactggatc gactctatca tccaacgctc cgaggacaac 5041 ccctgtcccc acccccggga cccggacccg gccagcagga cccactgaga agggctgccc 5101 gggtcacctc agctgcccac acccacactc tccagcatct ggcacaataa acattctctg 5161 ttttgtagaa tgtgtttgat gctccttggc tgtgtgattg ggtgttgaaa atggtcagta 5221 ggtcgggcgt ggtggctcac acctgtaatc ccagcacttt gggaggttga ggcaggcgga 5281 tcacttgagc tc

(2) INFORMATION FOR SEQ ID NO: 128: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1755 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 128: ctattgcagt atctttcagc ttccagtctt atctgaagac cccggcacca aagtgaccag

61 gaggcagaga agaacttcag aggagtctcg tcttgggctg cccgtgggtg agtgggaggg

121 tccgggactg cagaccggtg gcgatggcca ctctcccagc agcagaaacc tggatagacg

181 ggggtggagg cgtgggtgca gacgccgtga acctgaccgc ctcgctagct gccggggcgg

241 ccacgggggc agttgagact gggtggctgc aactgctgga ccaagctggc aacctctcct

301 cctccccttc cgcgctggga ctgcctgtgg cttcccccgc gccctcccag ccctgggcca

361 acctcaccaa ccagttcgtg cagccgtcct ggcgcatcgc gctctggtcc ctggcgtatg

421 gtgtggtggt ggcagtggca gttttgggaa atctcatcgt catctggatc atcctggccc

481 acaagcgcat gaggactgtc accaactact tccttgtgaa cctggctttc tccgacgcct

541 ccatggccgc cttcaacacg ttggtcaatt tcatctacgc gcttcatagc gagtggtact

601 ttggcgccaa ctactgccgc ttccagaact tctttcctat cacagctgtg ttcgccagca

661 tctactccat gacggccatt gcggtggaca ggtatatggc tattattgat cccttgaaac

721 ccagactgtc tgctacagca accaagattg tcattggaag tatttggatt ctagcatttc

781 tacttgcctt ccctcagtgt ctttattcca aaaccaaagt catgccaggc cgtactctct

841 gctttgtgca atggccagaa ggtcccaaac aacatttcac ttaccatatt atcgtcatta

901 tactggtgta ctgtttccca ttgctcatca tgggtattac atacaccatt gttggaatta

961 ctctctgggg aggagaaatc ccaggagata cctgtgacaa gtatcatgag cagctaaagg

1021 ccaaaagaaa ggttgtcaaa atgatgatta ttgttgtcat gacatttgct atctgctggc

1081 tgccctatca tatttacttc attctcactg caatctatca acaactaaat agatggaaat

1141 acatccagca ggtctacctg gctagctttt ggctggcaat gagctcaacc atgtacaatc

1201 ccatcatcta ctgctgtctg aataaaagat ttcgagctgg cttcaagaga gcatttcgct

1261 ggtgtccttt catcaaagtt tccagctatg atgagctaga gctcaagacc accaggtttc

1321 atccaaaccg gcaaagcagt atgtacaccg tgaccagaat ggagtccatg acagtcgtgt

1381 ttgaccccaa cgatgcagae accaccaggt ccagtcggaa gaaaagagea aegecaagag

1441 acccaagttt caatggctgc tctcgcagga attccaaatc tgcctccgcc acttcaagtt

1501 tcataagctc accctatacc tctgtggatg aatattctta attccatttc ctgaggtaaa

1561 agattagtgt gagaccatca tggtgccagt ctaggacccc attctcctat ttatcagtcc

1621 tgtcctatat accctctaga aacagaaagc aatttttagg cagetatggt caaattgaga

1681 aaggtagtgt ataaatgtga caaagacact aataacatgt tagcctccac ccaaaataaa

1741 atgggcttta aattt

(2) INFORMATION FOR SEQ ID NO: 129: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 600 base pairs

(B) TYPE: nucleic acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 129: ctgcagaccg gtggcgatgg ccatcctccc agcagcagaa acctggatag acgggggtgg

61 aggcgtgggt gcagacgccg tgaacctgac cgcctcgcta gctgccgggg cggccacggg

121 ggcagttgag actgggtggc tgcaactget ggaeeaagct ggcaacctet eetcetcccc

181 ttccgcgctg ggactgcctg tgcgttcccc cgcgccctcc cagccctggg ccaacctcac

241 caaccagttc gtgcagccgt cctggcgtat cgcgctctgg tccctggcgt atggtgtggt

301 ggtggcagtg gcagttttgg gaaatctcat cgtcatctgg atcatcctgg cccacaagcg

361 eatgaggact gtcaceaaet acttccttgt gaaeetggct ttctccgacg cetccatgge

421 cgccttcaac acgttggtca atttcatcta cgcgcttcat agcgagtggt actttggcgc

481 caactactgc cgcttccaga acttctttcc tatcacagct gtgttcgcca gcatctactc

541 catgacggcc attgcggtgg acaggtgagg agaggacaga cagagaggaa agagggagaa

INFORMATION FOR SEQ ID NO: 130: l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 227 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xι)SEQUENCE DESCRIPTION: SEQ ID NO:130: ggtatatggc tattattgat cccttgaaac ccagactgtc tgctacagca accaagattg

6 1 tcattggaag tatttggatt ctagcatttc tacttgcctt ccctcagtgt ctttattcca

12 1 aaaccaaagt catgccaggc cgtactctct gctttgtgca atggccagaa ggtcccaaac

18 1 aacatttcac gtaagttaat tctctattat ggttttcaat tcagttt

(2) INFORMATION FOR SEQ ID NO: 131: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 201 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 131: catgtgtttt tcttattttt catagttacc atattatcgt cattatactg gtgtactgtt

61 tcccattgct catcatgggt attacataca ccattgttgg aattactctc tggggaggag 121 aaatcccagg agatacctgt gacaagtatc atgagcagct aaaggccaaa agaaaggtac 181 tggtccatgt tgtttaccta g

(2) INFORMATION FOR SEQ ID NO: 132: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 255 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 132: caaatgactt tttctttata ggttgtcaaa atgatgatta ttgttgtcat gacatttgct

61 atctgctggc tgccctatca tatttacttc attctcactg caatctatca acaactaaat 121 agatggaaat acatccagca ggtctacctg gctagctttt ggctggcaat gagctcaacc 181 atgtacaatc ccatcatcta ctgctgtctg aataaaaggt aaaaacaaaa ctacgaaatg 241 caagttgctt gtcac

(2) INFORMATION FOR SEQ ID NO: 133: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 449 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 133: aaaataactt ttctttctgt ggcctgcttt tcctcagatt tcgagctggc ttcaagagag

61 catttcgctg gtgtcctttc atcaaagttt ccagctatga tgagctagag ctcaagacca 121 ccaggtttca tccaaaccgg caaagcagta tgtacaccgt gaccagaatg gagtccatga 181 cagtcgtgtt tgaccccaac gatgcagaca ccaccaggtc cagtcggaag aaaagagcaa 241 cgccaagaga cccaagtttc aatggctgct ctcgcaggaa ttccaaatct gcctccgcca 301 cttcaagttt cataagctca ccctatacct ctgtggatga atattcttaa ttccatttcc 361 tgaggtaaaa gattagtgtg agaccatcat ggtgccagtc taggacccca ttctcctatt 421 tatcagtcct gtcctatata ccctctaga

(2) INFORMATION FOR SEQ ID NO: 134: (i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3128 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 134: ctgcagaccg gtggcgatgg ccatcctccc agcagcagaa acctggatag acgggggtgg

61 aggcgtgggt gcagacgccg tgaacctgac cgcctcgcta gctgccgggg cggccacggg 121 ggcagttgag actgggtggc tgcaactget ggaeeaagct ggcaacctet eetcetcccc 181 ttccgcgctg ggactgcctg tgcgttcccc cgcgccctcc cagccctggg ccaacctcac 241 caaccagttc gtgcagccgt cctggcgtat cgcgctctgg tccctggcgt atggtgtggt 301 ggtggcagtg gcagttttgg gaaatctcat cgtcatctgg atcatcctgg cccacaagcg 361 eatgaggact gtcaceaaet acttccttgt gaaeetggct ttctccgacg cetccatgge 421 cgccttcaac acgttggtca atttcatcta cgcgcttcat agcgagtggt actttggcgc 481 caactactgc cgcttccaga acttctttcc tatcacagct gtgttcgcca gcatctactc 541 catgacggcc attgcggtgg acaggtgagg agaggacaga cagagaggaa agagggagaa ctattgcagt atctttcagc ttccagtctt atctgaagac cccggcacca aagtgaccag

61 gaggcagaga agaacttcag aggagtctcg tcttgggctg cccgtgggtg agtgggaggg

121 tccgggactg cagaccggtg gcgatggcca ctctcccagc agcagaaacc tggatagacg

181 ggggtggagg cgtgggtgca gacgccgtga acctgaccgc ctcgctagct gccggggcgg

241 ccacgggggc agttgagact gggtggctgc aactgctgga ccaagctggc aacctctcct

301 cctccccttc cgcgctggga ctgcctgtgg cttcccccgc gccctcccag ccctgggcca

361 acctcaccaa ccagttcgtg cagccgtcct ggcgcatcgc gctctggtcc ctggcgtatg

421 gtgtggtggt ggcagtggca gttttgggaa atctcatcgt catctggatc atcctggccc

481 acaagcgcat gaggactgtc accaactact tccttgtgaa cctggctttc tccgacgcct

541 ccatggccgc cttcaacacg ttggtcaatt tcatctacgc gcttcatagc gagtggtact

601 ttggcgccaa ctactgccgc ttccagaact tctttcctat cacagctgtg ttcgccagca

661 tctactccat gacggccatt gcggtggaca ggtatatggc tattattgat cccttgaaac

721 ccagactgtc tgctacagca accaagattg tcattggaag tatttggatt ctagcatttc

781 tacttgcctt ccctcagtgt ctttattcca aaaccaaagt catgccaggc cgtactctct

841 gctttgtgca atggccagaa ggtcccaaac aacatttcac ttaccatatt atcgtcatta

901 tactggtgta ctgtttccca ttgctcatca tgggtattac atacaccatt gttggaatta

961 ctctctgggg aggagaaatc ccaggagata cctgtgacaa gtatcatgag cagctaaagg

1021 ccaaaagaaa ggttgtcaaa atgatgatta ttgttgtcat gacatttgct atctgctggc

1081 tgccctatca tatttacttc attctcactg caatctatca acaactaaat agatggaaat

1141 acatccagca ggtctacctg gctagctttt ggctggcaat gagctcaacc atgtacaatc

1201 ccatcatcta ctgctgtctg aataaaagat ttcgagctgg cttcaagaga gcatttcgct

1261 ggtgtccttt catcaaagtt tccagctatg atgagctaga gctcaagacc accaggtttc

1321 atccaaaccg gcaaagcagt atgtacaccg tgaccagaat ggagtccatg acagtcgtgt

1381 ttgaccccaa cgatgcagae accaccaggt ccagtcggaa gaaaagagea aegecaagag

1441 acccaagttt caatggctgc tctcgcagga attccaaatc tgcctccgcc acttcaagtt

1501 tcataagctc accctatacc tctgtggatg aatattctta attccatttc ctgaggtaaa

1561 agattagtgt gagaccatca tggtgccagt ctaggacccc attctcctat ttatcagtcc

1621 tgtcctatat accctctaga aacagaaagc aatttttagg cagetatggt caaattgaga

1681 aaggtagtgt ataaatgtga caaagacact aataacatgt tagcctccac ccaaaataaa

1741 atgggcttta aattt ggtatatggc tattattgat cccttgaaac ccagactgtc tgctacagca accaagattg

61 tcattggaag tatttggatt ctagcatttc tacttgcctt ccctcagtgt ctttattcca 121 aaaccaaagt catgccaggc cgtactctct gctttgtgca atggccagaa ggtcccaaac 181 aacatttcac gtaagttaat tctctattat ggttttcaat tcagttt catgtgtttt tcttattttt catagttacc atattatcgt cattatactg gtgtactgtt

61 tcccattgct catcatgggt attacataca ccattgttgg aattactctc tggggaggag 121 aaatcccagg agatacctgt gacaagtatc atgagcagct aaaggccaaa agaaaggtac 181 tggtccatgt tgtttaccta g caaatgactt tttctttata ggttgtcaaa atgatgatta ttgttgtcat gacatttgct

61 atctgctggc tgccctatca tatttacttc attctcactg caatctatca acaactaaat 121 agatggaaat acatccagca ggtctacctg gctagctttt ggctggcaat gagctcaacc 181 atgtacaatc ccatcatcta ctgctgtctg aataaaaggt aaaaacaaaa ctacgaaatg 241 caagttgctt gtcac aaaataactt ttctttctgt ggcctgcttt tcctcagatt tcgagctggc ttcaagagag

61 catttcgctg gtgtcctttc atcaaagttt ccagctatga tgagctagag ctcaagacca 121 ccaggtttca tccaaaccgg caaagcagta tgtacaccgt gaccagaatg gagtccatga 181 cagtcgtgtt tgaccccaac gatgcagaca ccaccaggtc cagtcggaag aaaagagcaa 241 cgccaagaga cccaagtttc aatggctgct ctcgcaggaa ttccaaatct gcctccgcca 301 cttcaagttt cataagctca ccctatacct ctgtggatga atattcttaa ttccatttcc 361 tgaggtaaaa gattagtgtg agaccatcat ggtgccagtc taggacccca ttctcctatt 421 tatcagtcct gtcctatata ccctctaga

(2) INFORMATION FOR SEQ ID NO: 135: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2206 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 135: ctagtctttc agccttcagg ctgtttttgg cttgaagctc tcttggcctc ctagtttcta

61 cctaatcatg tccctggtgg aggccatcag cctctggaat gaaggggtgc tggcagcgga 121 caagaaggac tggaagggag ccctggatgc cttcagtgcc gtccaggacc cccactcccg

181 gatttgcttc aacattggct gcatgtacac tatcctgaag aacatgactg aagcagagaa

241 ggcctttacc agaagcatta accgagacaa gcacttggca gtggcttact tccaacgagg

301 gatgctctac taccagacag agaaatatga tttggctatc aaagacctta aagaagcctt

361 gattcagctt cgagggaacc agctgataga ctataagatc ctggggctcc agttcaagct

421 gtttgcctgt gaggtgttat ataacattgc tttcatgtat gccaagaagg aggaatggaa

481 aaaagctgaa gaacagttag cattggccac gagcatgaag tctgagccca gacattccaa

541 aatcgacaag gcgatggagt gtgtctggaa gcagaagcta tatgagccag tggtgatccc

601 tgtgggcaag ctgtttcgac caaatgagag acaagtggct cagctggcca agaaggatta

661 cctaggcaag gcgacggtcg tggcatctgt ggtggatcaa gacagtttct ctgggtttgc

721 ccctctgcaa ccacaggcag ctgagcctcc acccagaccg aaaaccccag agatcttcag

781 ggctctggaa ggggaggctc accgtgtgct atttgggttt gtgcctgaga caaaagaaga

841 gctccaggtc atgccaggga acattgtctt tgtcttgaag aagggcaatg ataactgggc

901 cacggtcatg ttcaacgggc agaaggggct tgttccctgc aactaccttg aaccagttga

961 gttgcggatc caccctcagc agcagcccca ggaggaaagc tctccgcagt ccgacatccc

1021 agctcctcct agttccaaag cccctggaaa accccagctg tcaccaggcc agaaacaaaa

1081 agaagagcct aaggaagtga agctcagtgt tcccatgccc tacacactca aggtgcacta

1141 caagtacacg gtagtcatga agactcagcc cgggctcccc tacagccagg tccgggacat

1201 ggtgtctaag aaactggagc tccggctgga acacactaag ctgagctatc ggcctcggga

1261 cagcaatgag ctggtgcccc tttcagaaga cagcatgaag gatgcctggg gccaggtgaa

1321 aaactactgc ctgactctgt ggtgtgagaa cacagtgggt gaccaaggct ttccagatga

1381 acccaaggaa agtgaaaaag ctgatgctaa taaccagaca acagaacctc agcttaagaa

1441 aggcagccaa gtggaggcac tcttcagtta tgaggctacc caaccagagg acctggagtt

1501 tcaggaaggg gatataatcc tggtgttatc aaaggtgaat gaagaatggc tggaagggga

1561 gtgcaaaggg aaggtgggca ttttccccaa agtttttgtt gaagactgcg caactacaga

1621 tttggaaagc actcggagag aagtctagga tgtttcacaa actacaaagc tgaagaaaat

1681 gaagccctat tacttgtttg taagatttag cacccttctg ctgtatactg tactgagaca

1741 ttacagtttg gaagtgttaa ctatttattc cctgttaaaa tttaacctac tagacaatga

1801 tgtgagtacc caggatgatt tcctggggca cagtgggtga ggagatgggg acaggtgaat

1861 ggaggagtta ggggagagga aaagtggatg gaagtgtctg gaaagggcac gagagagtct

1921 tccaggtact gatcctgttt cttgctctga gtgctagcta gccagctgtg ttcacactgt

1981 aaacattcat caagctgtac atttggtgca cttttetgtg tcataccaea ataaaaaaaa

2041 acctatcate atcttacaaa aaeaagacae ecaagtccag gcceaaggag taagtacaaa

2101 tattcctgtt tctgaaccat tactgtaatt ggctcttaag gcttgaagta accttatagg

2161 ttactcataa ggcatataca aataaacttg tttgttttct tttttc

(2) INFORMATION FOR SEQ ID NO:136: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1739 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 136: ctagtctttc agccttcagg ctgtttttgg cttgaagctc tcttggcctc ctagtttcta

61 cctaatcatg tccctggtgg aggccatcag cctctggaat gaaggggtgc tggcagcgga

121 caagaaggac tggaagggag ccctggatgc cttcagtgcc gtccaggacc cccactcccg

181 gatttgcttc aacattggct gcatgtacac tatcctgaag aacatgactg aagcagagaa

241 ggcctttacc agaagcatta accgagacaa gcacttggca gtggcttact tccaacgagg

301 gatgctctac taccagacag agaaatatga tttggctatc aaagacctta aagaagcctt

361 gattcagctt cgagggaacc agctgataga ctataagatc ctggggctcc agttcaagct

421 gtttgcctgt gaggtgttat ataacattgc tttcatgtat gccaagaagg aggaatggaa

481 aaaagctgaa gaacagttag cattggccac gagcatgaag tctgagccca gacattccaa

541 aatcgacaag gcgatggagt gtgtctggaa gcagaagcta tatgagccag tggtgatccc

601 tgtgggcaag ctgtttcgac caaatgagag acaagtggct cagctggcca agaaggatta

661 cctaggcaag gcgacggtcg tggcatctgt ggtggatcaa gacagtttct ctgggtttgc

721 ccctctgcaa ccacaggcag ctgagcctcc acccagaccg aaaaccccag agatcttcag

781 ggctctggaa ggggaggctc accgtgtgct atttgggttt gtgcctgaga caaaagaaga

841 gctccaggtc atgccaggga acattgtctt tgtcttgaag aagggcaatg ataactgggc

901 cacggtcatg ttcaacgggc agaaggggct tgttccctgc aactaccttg aaccagttga

961 gttgcggatc caccctcagc agcagcccca ggaggaaagc tctccgcagt ccgacatccc

1021 agctcctcct agttccaaag cccctggaaa accccagctg tcaccaggcc agaaacaaaa

1081 agaagagcct aaggaagtga agctcagtgt tcccatgccc tacacactca aggtgcacta

1141 caagtacacg gtagtcatga agactcagcc cgggctcccc tacagccagg tccgggacat

1201 ggtgtctaag aaactggagc tccggctgga acacactaag ctgagctatc ggcctcggga

1261 cagcaatgag ctggtgcccc tttcagaaga cagcatgaag gatgcctggg gccaggtgaa

1321 aaactactgc ctgactctgt ggtgtgagaa cacagtgggt gaccaaggct ttccagatga

1381 acccaaggaa agtgaaaaag ctgatgctaa taaccagaca acagaacctc agcttaagaa

1441 aggcagccaa gtggaggcac tcttcagtta tgaggctacc caaccagagg acctggagtt

1501 tcaggaaggg gatataatcc tggtgttatc aaaggtgaat gaagaatggc tggaagggga

1561 gtgcaaaggg aaggtgggca ttttccccaa agtttttgtt gaagactgcg caactacaga

1621 tttggaaagc actcggagag aagtctagga tgtttcacaa actacaaagc tgaagaaaat

1681 gaagccctat tacttgtttg taagatttag cacccttctg ctgtatactg tactgagaca 1741 ttacagtttg gaagtgttaa ctatttattc cctgttaaaa tttaacctac tagacaatga

1801 tgtgagtacc caggatgatt tcctggggca cagtgggtga ggagatgggg acaggtgaat

1861 ggaggagtta ggggagagga aaagtggatg gaagtgtctg gaaagggcac gagagagtct

1921 tccaggtact gatcctgttt cttgctctga gtgctagcta gccagctgtg ttcacactgt

1981 aaacattcat caagctgtac atttggtgca cttttetgtg tcataccaea ataaaaaaaa

2041 acctatcate atcttacaaa aaeaagacae ecaagtccag gcceaaggag taagtacaaa

2101 tattcctgtt tctgaaccat tactgtaatt ggctcttaag gcttgaagta accttatagg

2161 ttactcataa ggcatataca aataaacttg tttgttttct tttttc

(2) INFORMATION FOR SEQ ID NO: 137: (l) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 273 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 137: gcagagctgg gcaccacagg gagctaggct ctgtgagccg tggctcatct cacacctcct

61 cactgccttg catcatggcc atgtctggac ccttctctcc tcaggccttt accagaagca 121 ttaaccgaga caagcacttg gcagtggctt acttccaacg agggatgctc tactaccaga 181 cagagaagta agtggttcaa tgttgcacca actggaggat ttcagagaga aacccaaggg 241 gtctcagtgt tgcgggcttg gtgtttgagc agt

(2) INFORMATION FOR SEQ ID NO: 138: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 420 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(x ) SEQUENCE DESCRIPTION: SEQ ID NO: 138: ggtcagaagg aactgaaagg cttcttgtcc cagtgagata gctggggaag ggagaagcag

61 actcacattt tatgctgcat ttatttctcc atccactaga ctgctgattt tctccctctg

121 tcctggagat atgatttggc tatcaaagac cttaaagaag ccttgattca gcttcgaggg

181 aaccagctga tagactataa gatcctgggg ctccagttca agctgtttgc ctgtgaggta

241 aggagaacag ggcctggctg ggcaggaggg gatcatggct ggatggatgg ctgacagtca

301 gatgcacagt gatctgttga cacctccagg agcttggaaa agccatttct cctctgcctt

361 gagactcaga ttttccttga agaaaagact gagatggatt atttcaggct catcaaggca

(2) INFORMATION FOR SEQ ID NO:139: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 780 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 139: ttccctggca ccttgatttg gagtagtctc aagttttatg tttgcggtct gtacttttct

61 aggtgttata taacattgct ttcatgtatg ccaagaagga ggaatggaaa aaagctgaag

121 aacagttagc attggccacg agcatgaagt ctgagcccag acattccaaa atcgacaagg

181 cgatggagtg tgtctgggta agcgtattgg tgatgcaggt gttgagagga tgtcactgga

241 ttctcatttg tctcagagga catgccattg agaagccata aaagtggtgc ttttactttc

301 tgtgagtctg ggtaacactg atcttagggt atagttccac ttaagatctt gaatctgtgc

361 tgagaagctg aggcctagag tatgggatgg cagagcctgg catcacacca cccttggagt

421 ggggctcctt ggcaatgcag gagaacagga tattggatgc tggagcagtg ctgcacagac

481 tctaagcact gagagggcag agtccatgtc tgcttgatca ccactgagtc ctcacagcct

541 ggcacagtgc taggccacat aacagctctc agcaaaaatg ttttgttttg ttttgagatg

601 gagtctcgct ctgttgccca gcctggagtg cagtggtgtg atctcagctc actgcagcct

661 ctgcctcctg ggttcaagca attctgctgc ctcagccgcc caagtagctg ggattacagg

721 tgcatgccac catgcctggc taatttttgt atttttaata gagacggggt tttgccatgt

(2) INFORMATION FOR SEQ ID NO: 140: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 278 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 140: gaattcttgc atctattcac tgagggaggc aggacaagca tcgtcacccc cattttcaca

61 taagggaatg ctacgttttc tgtgttacag aagcagaagc tatatgagcc agtggtgatc 121 cctgtgggca agctgtttcg accaaatgag agacaagtgg ctcagctggc caagaaggat 181 tacctaggca aggcgacggt aggtgggatt gctcagcttc ccctgagtct tcctgtggcc 241 cgggcatgtg gagcaaggtg ggagggactc ttgagaag (2) INFORMATION FOR SEQ ID NO: 141: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 705 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO :141: gcaggagaat cacttgaacc tggaaggcag aggttgcagt gagctgagtc actccactgc 61 actccagtct gggtaacaga gcgtgctccg tctcaaaaaa aaaaaaaaaa aaaaagataa 121 tttgatgtta tacaaattgc acctcaatta aaaacatttc ttttttaaga gagaagaaag 181 caagcctgtg ttagcagggg tggggtgaat gctcgtttct tcagttgctg aaatcctaat 241 ccagaggctc aggaatctaa tccttagtta ctgtccacgt ctgaaaccag gctcacgtaa 301 gaacaggtct agggcatgag caaagaggga gacccagaag aatggaaaca gtgctggcag 361 agcctcacac cctcctgtcc ttgattttag gtcgtggcat ctgtggtgga tcaagacagt 421 ttctctgggt ttgcccctct gcaaccacag gtaaggcagt cctgaccttc tccatggacc 481 taggtctcga gagctttctg tgaagcattc aattcgagag actatgtgtg ctgagttgcc 541 tgattgtaag ggctccttca agtggccctc agtgcagctg aggattctgc ctgccctctc 601 tcagtcctgg tttccatggc tggtgaggaa ataaggcagt gteaggcttc accccaagtc 661 ctctgaagct aactctcctg cttccccaca aatgccggtc ttcac

(2) INFORMATION FOR SEQ ID NO: 142: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 709 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 142: actgaattgc tgtgctagtg aaacctgtac ctgggagctg gtgggaggtg ttatttccca

61 gtgtttagtc agggtgactg tgccctcttc ctagacagtg ttctcatcag tcagaaatgc 121 gttatttgat tttctggtct ggaagaatgc tcaaattacc attagccgtt tgttgtctct 181 cccctgcttt ccctcattgc cttttccgtt ttcacttctc ctgaatgttc aataggcagc 241 tgageetcea cccagaccga aaaccccaga gatctteagg taagttagat tcaaateeat 301 aaatagaata tcaagcgcca agcctgagct gatggcaaga aagggaggga agaagatgaa 361 ggtggggtca gggtetaaat cttgttgaat tttctggaat gteaggcttc ttetagaatg 421 tcaggctaga aaggaatgcc tagaagaatg tcttctagaa tgtcaggcta gaaaggaatg 481 atatatgggg atgggagtct tgactgtggt ggggctggcc atcagggctt ggctgcagct 541 aegtggtcea ttggccetct gteeaegtgc acagceaeca eatgcagggg ttgtgctgag 601 ggcagtgtgt cctgtggaac atagctacct gggaccagat gctgacctca ggttggagat 661 cggtttcgca ctggctgcag tcctctgacg gggcaggcca gagctctct

(2) INFORMATION FOR SEQ ID NO: 143: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 849 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 143: tgagcagtgt acaccagttt cttgctgaga cctcttggac ccaggcaggc tcagtgtcat

61 ctcggcagtt gcagttagat gtggagttag agccaggctg agccaagtcc ctggctccaa 121 gttcagtgta tttgcgccat ggcatcatgt gaggggatgg gggctggatc ttgtgtctat 181 cctctgcagg gctctggaag gggaggctca ccgtgtgcta tttgggtttg tgcctgagac 241 aaaagaagag ctccaggtca tgccagggaa cattgtcttt gtcttgaaga agggcaatga 301 taactgggcc acggtcatgt tcaacgggca ggtatgcaga ggatcagggg ctggtgcgat 361 gggcatggga tcctggcagc aaatgcagtc tctgtggagc agtatctgct gccttctttg 421 cagaccagcc aagttctttt gtctgttcgt catcccttcc ccaggactct gggctgttct 481 gtggtgtggg tactgatgag cacatcttta ttttttcctt tctgattctg tggtgctgca 541 ctgcagaagg ggcttgttcc ctgcaactac cttgaaccag ttgagctgcg gatccaccct 601 cagcagcagc cccaggtaat gtgatgccaa ggcctgaccc atttcctctc accctttagg 661 atctctccct ggagggagaa aagcagtgta aaagaggtgt tgtcaggacc cctggagaaa 721 gattcactag tcttgagccc gccttgagat ggcaccagct acccagagct gaacctggga 781 atgaggggaa aaaagcccag atgtgctaag ttggaggcat ctgtaggtcc cattggccca 841 cccacctct

(2) INFORMATION FOR SEQ ID NO: 144: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 308 base pairs

(B) TYPE: nucleic aciα

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 144: aatgtcacta ccattccaac ttttaggacg ttatctgcat gtggctcctt tacatggggt

61 ctctgtaggg gtgtttcccc acatccaccc ctgcctggga actttgaatg aaggttctga 121 ccatcgctcc ctgttgcctt caggaggaaa gctctccgca gtccgacatc ccagctcctc 181 ctagttccaa agcccctgga agaccccagc tgtcaccagg tgagtggtcc tggagccaca 241 gcctaggttt gggtgcagca gcatgccagg tgttcctgag ttcctctccc tgccttccag 301 gaaattct

(2) INFORMATION FOR SEQ ID NO: 145: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 463 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:145: gactgagttt gttcatgtgt tcatgacctt catgcttccc cagggcgaga tttccccaca

61 gtttactaag gttaataatt gccccacaaa ttaaagggta agaggttggg ggccctattt 121 gaagaggttt catctgtgtg tggcaggggc tggccaagga tgttcattca ccatcttctt 181 ttgttttact ccctactttt tccattcagg ccagaaacaa aaagaagagc ctaaggtaac 241 atttttccct catactgttt caagtggtag aagatgggat agcttgggct atcaaccaca 301 gacatgtctg tetggattat aggaagagcc caaaggaggg tcgaaceagt tgetacctta 361 cagagtccat gagctaggga ccttcttaat agcctcctcc actatcatgc acacacttcc 421 tactacccaa gctagtgggc cagatcttac tcagtaggaa ttc

(2) INFORMATION FOR SEQ ID NO: 146: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 784 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 146: gaattcctgt ccaagcaagg gttgggctaa aggacctctg aaggcctttt aggctactgt

61 gaaaccagtt acttactggc ctctcccctg ctgtattggg taccccctgt gccaaatcac 121 gaaactgcgg tgatccagga tgttgagaga aagcctcaga cactcaggag ttccctttgt 181 ttcctcccca ctcaggaagt gaagctcagt gttcccatgc cctacacact caaggtgcac 241 tacaagtaca eggtagteat gaagacteag eecgggctce eetacagcca ggtecgggac 301 atggtgtcta agaaactgga gctccggctg gaacacacta agctgaggtg agctccatgc 361 aggcagctgt gaggggtaca gtgggaacct tgtgctggcc tggaggaggg aagaggagga 421 tggtttttgt gatgatgttc tttgactgga ttcttactca ttatccccac ccagctatcg 481 geetegggac agcaatgage tggtgcccct ttcagaagae agcatgaagg atgcetgggg 541 ccaggtgaaa aactactgcc tgactctgtg gtgtgagaac acagtggtga gtgcaatgag 601 gggcatctaa agttacattt ccactgagcc acttcctcaa caatttgaaa tttatcaagc 661 accttctgtg tactaggcac tatatgtggt gttggggata tggtgtgtaa taagtcacag 721 ctctgcctcc cttttacctg catcctcacc ccatttgcag cagggagaga gtttcccaca 781 agag

(2) INFORMATION FOR SEQ ID NO: 147: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 450 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 147: ttcataaaga gcatataagc tctacacaag gcactgatca caaactttat gagtttatat

61 cccaggttct actttgacat ttcgctgttt cctttagtga tgttcagtgt tcacttggca 121 ggaaattggg aaaattaaca ggccctttat tatttcaggg tgaccaaggc tttccagatg 181 aacccaagga aagtgaaaaa gctgatgcta ataaccagac aacagaacct cagcttaaga 241 aaggcagcca agtggaggca ctcttcagtt atgaggctac ccaaccagag gacctggagt 301 ttcaggaagg ggatataatc ctggtgttat caaagggtaa gtgctactcc aagactatag 361 aaacaaattt acatgttagc agaaacaagg tcaagggcag agagaagaaa tatcaataat 421 ctacaaacaa aactttagcc agtgttttca

(2) INFORMATION FOR SEQ ID NO: 148: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1145 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 148: gtcaattctt gaccctcttc tctatctggt aactttttga aaaacataat ttatcctctc

61 ttcattttgc tcattatcat gtttaagaca gatcaataag atggttaaac cctgtgttca

121 ctctcaaacc actttgcaat actgtctttt ccctgttgat cacaattagg ggtggggaag

181 ggtgaccgat aacaaattct gtgtggaata gccagacagg gtaatcttcc tacagtggtt

241 ttagaaatcc atgtgtactt ttccttttat cagtgaatga agaatggctg gaaggggagt

301 gcaaagggaa ggtgggcatt ttccccaaag tttttgttga agactgcgca actacagatt 361 tggaaagcac tcggagagaa αtctaggatg tttcacaaac tacaaagctg aagaaaatga

421 agccctatta cttgtttgta agatttagca cccttctgct gtatactgta ctgagacatt

481 acagtttgga agtgttaact atttattccc tgttaaaatt taacctacta gacaatgatg

541 tgagtaccca ggatgatttc ctggggcaca gtgggtgagg agatggggac aggtgaatgg

601 aggagttagg ggagaggaaa agtggatgga agtgtctgga aagggcacga gagagtcttc

661 caggtactga tcctgtttct tgctctgagt gctagctagc cagctgtgtt cacactgtaa

721 acattcatca agctgtacat ttggtgcact tttctgtgtc ataccacaat aaaaaaaaac

781 ctatcatctt acaaaaacaa gacacccaag tccaggccca aggagtaagt acaaatattc

841 ctgtttctga accattactg taattggctc ttaaggcttg aagtaacctt ataggttact

901 cataaggcat atacaaataa acttgtttgt tttctttttt cattatgtct tgttgcttaa

961 acagaaccta gactgagtta ggttctcatg gactacaaca ctcaattcca cagagaatta

1021 atagaattac ataectttgt acattctcag agaggaaeat gtgttaagaa ctcaataetg

1081 aatatatatc aatcgccaac atttaagtga tgaaaagcag cggtgttcat gaagctagtt

1141 cgtaa

(2) INFORMATION FOR SEQ ID NO: 149: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 75 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xι)SEQUENCE DESCRIPTION: SEQ ID NO:149: gtcacatcgc cctgctgggc tttgagaagc gcttcgtacc cagccagcac tatgtgtaca 61 tgttcctggt gaaat

(2) INFORMATION FOR SEQ ID NO: 150: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10335 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:150: ctagtctttc agccttcagg ctgtttttgg cttgaagctc tcttggcctc ctagtttcta

61 cctaatcatg tccctggtgg aggccatcag cctctggaat gaaggggtgc tggcagcgga

121 caagaaggac tggaagggag ccctggatgc cttcagtgcc gtccaggacc cccactcccg

181 gatttgcttc aacattggct gcatgtacac tatcctgaag aacatgactg aagcagagaa

241 ggcctttacc agaagcatta accgagacaa gcacttggca gtggcttact tccaacgagg

301 gatgctctac taccagacag agaaatatga tttggctatc aaagacctta aagaagcctt

361 gattcagctt cgagggaacc agctgataga ctataagatc ctggggctcc agttcaagct

421 gtttgcctgt gaggtgttat ataacattgc tttcatgtat gccaagaagg aggaatggaa

48 811 aaaagctgaa gaacagttag cattggccac gagcatgaag tctgagccca gacattccaa

541 aatcgacaag gcgatggagt gtgtctggaa gcagaagcta tatgagccag tggtgatccc

601 tgtgggcaag ctgtttcgac caaatgagag acaagtggct cagctggcca agaaggatta

661 cctaggcaag gcgacggtcg tggcatctgt ggtggatcaa gacagtttct ctgggtttgc

721 ccctctgcaa ccacaggcag ctgagcctcc acccagaccg aaaaccccag agatcttcag

781 ggctctggaa ggggaggctc accgtgtgct atttgggttt gtgcctgaga caaaagaaga

841 gctccaggtc atgccaggga acattgtctt tgtcttgaag aagggcaatg ataactgggc

901 cacggtcatg ttcaacgggc agaaggggct tgttccctgc aactaccttg aaccagttga

961 gttgcggatc caccctcagc agcagcccca ggaggaaagc tctccgcagt ccgacatccc

1021 agctcctcct agttccaaag cccctggaaa accccagctg tcaccaggcc agaaacaaaa

1081 agaagagcct aaggaagtga agctcagtgt tcccatgccc tacacactca aggtgcacta

1141 caagtacacg gtagtcatga agactcagcc cgggctcccc tacagccagg tccgggacat

1201 ggtgtctaag aaactggagc tccggctgga acacactaag ctgagctatc ggcctcggga

1261 cagcaatgag ctggtgcccc tttcagaaga cagcatgaag gatgcctggg gccaggtgaa

1321 aaactactgc ctgactctgt ggtgtgagaa cacagtgggt gaccaaggct ttccagatga

1381 acccaaggaa agtgaaaaag ctgatgctaa taaccagaca acagaacctc agcttaagaa

1441 aggcagccaa gtggaggcac tcttcagtta tgaggctacc caaccagagg acctggagtt

1501 tcaggaaggg gatataatcc tggtgttatc aaaggtgaat gaagaatggc tggaagggga

1561 gtgcaaaggg aaggtgggca ttttccccaa agtttttgtt gaagactgcg caactacaga

1621 tttggaaagc actcggagag aagtctagga tgtttcacaa actacaaagc tgaagaaaat

1681 gaagccctat tacttgtttg taagatttag cacccttctg ctgtatactg tactgagaca

1741 ttacagtttg gaagtgttaa ctatttattc cctgttaaaa tttaacctac tagacaatga

1801 tgtgagtacc caggatgatt tcctggggca cagtgggtga ggagatgggg acaggtgaat

1861 ggaggagtta ggggagagga aaagtggatg gaagtgtctg gaaagggcac gagagagtct

1921 tccaggtact gatcctgttt cttgctctga gtgctagcta gccagctgtg ttcacactgt

1981 aaacattcat caagctgtac atttggtgca cttttetgtg tcataccaea ataaaaaaaa

2041 acctatcate atcttacaaa aaeaagacae ecaagtccag gcceaaggag taagtacaaa

2101 tattcctgtt tctgaaccat tactgtaatt ggctcttaag gcttgaagta accttatagg

2161 ttactcataa ggcatataca aataaacttg tttgttttct tttttc ctagtctttc agccttcagg ctgtttttgg cttgaagctc tcttggcctc ctagtttcta

61 cctaatcatg tccctggtgg aggccatcag cctctggaat gaaggggtgc tggcagcgga 121 caagaaggac tggaagggag ccctggatgc cttcagtgcc gtccaggacc cccactcccg 181 αatttgette aacattggct gcatgtacac tatcctgaag aacatgactg aagcagagaa 241 ggcctttacc agaagcatta accgagacaa gcacttggca gtggcttact tccaacgagg

301 gatgctctac taccagacag agaaatatga tttggctatc aaagacctta aagaagcctt

361 gattcagctt cgagggaacc agctgataga ctataagatc ctggggctcc agttcaagct

421 gtttgcctgt gaggtgttat ataacattgc tttcatgtat gccaagaagg aggaatggaa

481 aaaagctgaa gaacagttag cattggccac gagcatgaag tctgagccca gacattccaa

541 aatcgacaag gcgatggagt gtgtctggaa gcagaagcta tatgagccag tggtgatccc

601 tgtgggcaag ctgtttcgac caaatgagag acaagtggct cagctggcca agaaggatta

661 cctaggcaag gcgacggtcg tggcatctgt ggtggatcaa gacagtttct ctgggtttgc

721 ccctctgcaa ccacaggcag ctgagcctcc acccagaccg aaaaccccag agatcttcag

781 ggctctggaa ggggaggctc accgtgtgct atttgggttt gtgcctgaga caaaagaaga

841 gctccaggtc atgccaggga acattgtctt tgtcttgaag aagggcaatg ataactgggc

901 cacggtcatg ttcaacgggc agaaggggct tgttccctgc aactaccttg aaccagttga

961 gttgcggatc caccctcagc agcagcccca ggaggaaagc tctccgcagt ccgacatccc

1021 agctcctcct agttccaaag cccctggaaa accccagctg tcaccaggcc agaaacaaaa

1081 agaagagcct aaggaagtga agctcagtgt tcccatgccc tacacactca aggtgcacta

1141 caagtacacg gtagtcatga agactcagcc cgggctcccc tacagccagg tccgggacat

1201 ggtgtctaag aaactggagc tccggctgga acacactaag ctgagctatc ggcctcggga

1261 cagcaatgag ctggtgcccc tttcagaaga cagcatgaag gatgcctggg gccaggtgaa

1321 aaactactgc ctgactctgt ggtgtgagaa cacagtgggt gaccaaggct ttccagatga

1381 acccaaggaa agtgaaaaag ctgatgctaa taaccagaca acagaacctc agcttaagaa

1441 aggcagccaa gtggaggcac tcttcagtta tgaggctacc caaccagagg acctggagtt

1501 tcaggaaggg gatataatcc tggtgttatc aaaggtgaat gaagaatggc tggaagggga

1561 gtgcaaaggg aaggtgggca ttttccccaa agtttttgtt gaagactgcg caactacaga

1621 tttggaaagc actcggagag aagtctagga tgtttcacaa actacaaagc tgaagaaaat

1681 gaagccctat tacttgtttg taagatttag cacccttctg ctgtatactg tactgagaca

1741 ttacagtttg gaagtgttaa ctatttattc cctgttaaaa tttaacctac tagacaatga

1801 tgtgagtacc caggatgatt tcctggggca cagtgggtga ggagatgggg acaggtgaat

1861 ggaggagtta ggggagagga aaagtggatg gaagtgtctg gaaagggcac gagagagtct

1921 tccaggtact gatcctgttt cttgctctga gtgctagcta gccagctgtg ttcacactgt

1981 aaacattcat caagctgtac atttggtgca cttttetgtg tcataccaea ataaaaaaaa

2041 acctatcate atcttacaaa aaeaagacae ecaagtccag gcceaaggag taagtacaaa

2101 tattcctgtt tctgaaccat tactgtaatt ggctcttaag gcttgaagta accttatagg

2161 ttactcataa ggcatataca aataaacttg tttgttttct tttttc gcagagctgg gcaccacagg gagctaggct ctgtgagccg tggctcatct cacacctcct

61 cactgccttg catcatggcc atgtctggac ccttctctcc tcaggccttt accagaagca

121 ttaaccgaga caagcacttg gcagtggctt acttccaacg agggatgctc tactaccaga

181 cagagaagta agtggttcaa tgttgcacca actggaggat ttcagagaga aacccaaggg 241 gtctcagtgt tgcgggcttg gtgtttgagc agt ggtcagaagg aactgaaagg cttcttgtcc cagtgagata gctggggaag ggagaagcag

61 actcacattt tatgctgcat ttatttctcc atccactaga ctgctgattt tctccctctg

121 tcctggagat atgatttggc tatcaaagac cttaaagaag ccttgattca gcttcgaggg

181 aaccagctga tagactataa gatcctgggg ctccagttca agctgtttgc ctgtgaggta

241 aggagaacag ggcctggctg ggcaggaggg gatcatggct ggatggatgg ctgacagtca

301 gatgcacagt gatctgttga cacctccagg agcttggaaa agccatttct cctctgcctt

361 gagactcaga ttttccttga agaaaagact gagatggatt atttcaggct catcaaggca ttccctggca ccttgatttg gagtagtctc aagttttatg tttgcggtct gtacttttct

61 aggtgttata taacattgct ttcatgtatg ccaagaagga ggaatggaaa aaagctgaag

121 aacagttagc attggccacg agcatgaagt ctgagcccag acattccaaa atcgacaagg

181 cgatggagtg tgtctgggta agcgtattgg tgatgcaggt gttgagagga tgtcactgga

241 ttctcatttg tctcagagga catgccattg agaagccata aaagtggtgc ttttactttc

301 tgtgagtctg ggtaacactg atcttagggt atagttccac ttaagatctt gaatctgtgc

361 tgagaagctg aggcctagag tatgggatgg cagagcctgg catcacacca cccttggagt

421 ggggctcctt ggcaatgcag gagaacagga tattggatgc tggagcagtg ctgcacagac

481 tctaagcact gagagggcag agtccatgtc tgcttgatca ccactgagtc ctcacagcct

541 ggcacagtgc taggccacat aacagctctc agcaaaaatg ttttgttttg ttttgagatg

601 gagtctcgct ctgttgccca gcctggagtg cagtggtgtg atctcagctc actgcagcct

661 ctgcctcctg ggttcaagca attctgctgc ctcagccgcc caagtagctg ggattacagg

721 tgcatgccac catgcctggc taatttttgt atttttaata gagacggggt tttgccatgt gaattcttgc atctattcac tgagggaggc aggacaagca tcgtcacccc cattttcaca

61 taagggaatg ctacgttttc tgtgttacag aagcagaagc tatatgagcc agtggtgatc

121 cctgtgggca agctgtttcg accaaatgag agacaagtgg ctcagctggc caagaaggat

181 tacctaggca aggcgacggt aggtgggatt gctcagcttc ccctgagtct tcctgtggcc 241 cgggcatgtg gagcaaggtg ggagggactc ttgagaag gcaggagaat cacttgaacc tggaaggcag aggttgcagt gagctgagtc actccactgc

61 actccagtct gggtaacaga gcgtgctccg tctcaaaaaa aaaaaaaaaa aaaaagataa

121 tttgatgtta tacaaattgc acctcaatta aaaacatttc ttttttaaga gagaagaaag

181 caagcctgtg ttagcagggg tggggtgaat gctcgtttct tcagttgctg aaatcctaat

241 ccagaggctc aggaatctaa tccttagtta ctgtccacgt ctgaaaccag gctcacgtaa

301 gaacaggtct agggcatgag caaagaggga gacccagaag aatggaaaca gtgctggcag

361 agcctcacac cctcctgtcc ttgattttag gtcgtggcat ctgtggtgga tcaagacagt

421 ttctctgggt ttgcccctct gcaaccacag gtaaggcagt cctgaccttc tccatggacc

481 taggtctcga gagctttctg tgaagcattc aattcgagag actatgtgtg ctgagttgcc

541 tgattgtaag ggctccttca agtggccctc agtgcagctg aggattctgc ctgccctctc

601 tcagtcctgg tttccatggc tggtgaggaa ataaggcagt gteaggcttc accccaagtc 661 ctctgaagct aactctcctg cttccccaca aatgccggtc ttcac actgaattgc tgtgctagtg aaacctgtac ctgggagctg gtgggaggtg ttatttccca

61 gtgtttagtc agggtgactg tgccctcttc ctagacagtg ttctcatcag tcagaaatgc 121 gttatttgat tttctggtct ggaagaatgc tcaaattacc attagccgtt tgttgtctct 181 cccctgcttt ccctcattgc cttttccgtt ttcacttctc ctgaatgttc aataggcagc 241 tgageetcea cccagaccga aaaccccaga gatctteagg taagttagat tcaaateeat 301 aaatagaata tcaagcgcca agcctgagct gatggcaaga aagggaggga agaagatgaa 361 ggtggggtca gggtetaaat cttgttgaat tttctggaat gteaggcttc ttetagaatg 421 tcaggctaga aaggaatgcc tagaagaatg tcttctagaa tgtcaggcta gaaaggaatg 481 atatatgggg atgggagtct tgactgtggt ggggctggcc atcagggctt ggctgcagct 541 aegtggtcea ttggccetct gteeaegtgc acagceaeca eatgcagggg ttgtgctgag 601 ggcagtgtgt cctgtggaac atagctacct gggaccagat gctgacctca ggttggagat 661 cggtttcgca ctggctgcag tcctctgacg gggcaggcca gagctctct tgagcagtgt acaccagttt cttgctgaga cctcttggac ccaggcaggc tcagtgtcat

61 ctcggcagtt gcagttagat gtggagttag agccaggctg agccaagtcc ctggctccaa 121 gttcagtgta tttgcgccat ggcatcatgt gaggggatgg gggctggatc ttgtgtctat 181 cctctgcagg gctctggaag gggaggctca ccgtgtgcta tttgggtttg tgcctgagac 241 aaaagaagag ctccaggtca tgccagggaa cattgtcttt gtcttgaaga agggcaatga 301 taactgggcc acggtcatgt tcaacgggca ggtatgcaga ggatcagggg ctggtgcgat 361 gggcatggga tcctggcagc aaatgcagtc tctgtggagc agtatctgct gccttctttg 421 cagaccagcc aagttctttt gtctgttcgt catcccttcc ccaggactct gggctgttct 481 gtggtgtggg tactgatgag cacatcttta ttttttcctt tctgattctg tggtgctgca 541 ctgcagaagg ggcttgttcc ctgcaactac cttgaaccag ttgagctgcg gatccaccct 601 cagcagcagc cccaggtaat gtgatgccaa ggcctgaccc atttcctctc accctttagg 661 atctctccct ggagggagaa aagcagtgta aaagaggtgt tgtcaggacc cctggagaaa 721 gattcactag tcttgagccc gccttgagat ggcaccagct acccagagct gaacctggga 781 atgaggggaa aaaagcccag atgtgctaag ttggaggcat ctgtaggtcc cattggccca 841 cccacctct aatgtcacta ccattccaac ttttaggacg ttatctgcat gtggctcctt tacatggggt

61 ctctgtaggg gtgtttcccc acatccaccc ctgcctggga actttgaatg aaggttctga 121 ccatcgctcc ctgttgcctt caggaggaaa gctctccgca gtccgacatc ccagctcctc 181 ctagttccaa agcccctgga agaccccagc tgtcaccagg tgagtggtcc tggagccaca 241 gcctaggttt gggtgcagca gcatgccagg tgttcctgag ttcctctccc tgccttccag 301 gaaattct gactgagttt gttcatgtgt tcatgacctt catgcttccc cagggcgaga tttccccaca

61 gtttactaag gttaataatt gccccacaaa ttaaagggta agaggttggg ggccctattt 121 gaagaggttt catctgtgtg tggcaggggc tggccaagga tgttcattca ccatcttctt 181 ttgttttact ccctactttt tccattcagg ccagaaacaa aaagaagagc ctaaggtaac 241 atttttccct catactgttt caagtggtag aagatgggat agcttgggct atcaaccaca 301 gacatgtctg tetggattat aggaagagcc caaaggaggg tcgaaceagt tgetacctta 361 cagagtccat gagctaggga ccttcttaat agcctcctcc actatcatgc acacacttcc 421 tactacccaa gctagtgggc cagatcttac tcagtaggaa ttc gaattcctgt ccaagcaagg gttgggctaa aggacctctg aaggcctttt aggctactgt

61 gaaaccagtt acttactggc ctctcccctg ctgtattggg taccccctgt gccaaatcac 121 gaaactgcgg tgatccagga tgttgagaga aagcctcaga cactcaggag ttccctttgt 181 ttcctcccca ctcaggaagt gaagctcagt gttcccatgc cctacacact caaggtgcac 241 tacaagtaca eggtagteat gaagacteag eecgggctce eetacagcca ggtecgggac 301 atggtgtcta agaaactgga gctccggctg gaacacacta agctgaggtg agctccatgc 361 aggcagctgt gaggggtaca gtgggaacct tgtgctggcc tggaggaggg aagaggagga 421 tggtttttgt gatgatgttc tttgactgga ttcttactca ttatccccac ccagctatcg 481 geetegggac agcaatgage tggtgcccct ttcagaagae agcatgaagg atgcetgggg 541 ccaggtgaaa aactactgcc tgactctgtg gtgtgagaac acagtggtga gtgcaatgag 601 gggcatctaa agttacattt ccactgagcc acttcctcaa caatttgaaa tttatcaagc 661 accttctgtg tactaggcac tatatgtggt gttggggata tggtgtgtaa taagtcacag 721 ctctgcctcc cttttacctg catcctcacc ccatttgcag cagggagaga gtttcccaca 781 agag ttcataaaga gcatataagc tctacacaag gcactgatca caaactttat gagtttatat

61 cccaggttct actttgacat ttcgctgttt cctttagtga tgttcagtgt tcacttggca 121 ggaaattggg aaaattaaca ggccctttat tatttcaggg tgaccaaggc tttccagatg 181 aacccaagga aagtgaaaaa gctgatgcta ataaccagac aacagaacct cagcttaaga 241 aaggcagcca agtggaggca ctcttcagtt atgaggctac ccaaccagag gacctggagt 301 ttcaggaagg ggatataatc ctggtgttat caaagggtaa gtgctactcc aagactatag 361 aaacaaattt acatgttagc agaaacaagg tcaagggcag agagaagaaa tatcaataat 421 ctacaaacaa aactttagcc agtgttttca gtcaattctt gaccctcttc tctatctggt aactttttga aaaacataat ttatcctctc

61 ttcattttgc tcattatcat gtttaagaca gatcaataag atggttaaac cctgtgttca 121 ctctcaaacc actttgcaat actgtctttt ccctgttgat cacaattagg ggtggggaag 181 ggtgaccgat aacaaattct gtgtggaata gccagacagg gtaatcttcc tacagtggtt 241 ttagaaatcc atgtgtactt ttccttttat cagtgaatga agaatggctg gaaggggagt 301 gcaaagggaa ggtgggcatt ttccccaaag tttttgttga agactgcgca actacagatt 361 tggaaagcac tcggagagaa gtctaggatg tttcacaaac tacaaagctg aagaaaatga 421 agccctatta cttgtttgta agatttagca cccttctgct gtatactgta ctgagacatt 481 acagtttgga agtgttaact atttattccc tgttaaaatt taacctacta gacaatgatg 541 tgagtaccca ggatgatttc ctggggcaca gtgggtgagg agatggggac aggtgaatgg 601 aggagttagg ggagaggaaa agtggatgga agtgtctgga aagggcacga gagagtcttc 661 caggtactga tcctgtttct tgctctgagt gctagctagc cagctgtgtt cacactgtaa 721 acattcatca agctgtacat ttggtgcact tttctgtgtc ataccacaat aaaaaaaaac

781 ctatcatctt acaaaaacaa gacacccaag tccaggccca aggagtaagt acaaatattc

841 ctgtttctga accattactg taattggctc ttaaggcttg aagtaacctt ataggttact

901 cataaggcat atacaaataa acttgtttgt tttctttttt cattatgtct tgttgcttaa

961 acagaaccta gactgagtta ggttctcatg gactacaaca ctcaattcca cagagaatta

1021 atagaattac ataectttgt acattctcag agaggaaeat gtgttaagaa ctcaataetg

1081 aatatatatc aatcgccaac atttaagtga tgaaaagcag cggtgttcat gaagctagtt

1141 cgtaa gtcacatcgc cctgctgggc tttgagaagc gcttcgtace cagccagcac tatgtgtaca

61 tgttcctggt gaaat

(2) INFORMATION FOR SEQ ID NO: 151: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1064 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 151: ccagctgata ttccagccca cagcaatgga gccacatgac tcctcccaca tggactctga

61 gttccgatac actctcttcc cgattgttta cagcatcatc tttgtgctcg gggtcattgc

121 taatggctac gtgctgtggg tctttgcccg cctgtaccct tgcaagaaat tcaatgagat

181 aaagatcttc atggtgaacc tcaccatggc ggacatgctc ttcttgatca ccctgccact

241 ttggattgtc tactaccaaa accagggcaa ctggatactc cccaaattcc tgtgcaacgt

301 ggctggctgc cttttcttca tcaacaccta ctgctctgtg gccttcctgg gcgtcatcac

361 ttataaccgc ttccaggcag taactcggcc catcaagact gctcaggcca acacccgcaa

421 gcgtggcatc tctttgtcct tggtcatctg ggtggccatt gtgggagctg catcctactt

481 cctcatcctg gactctacca acacagtgcc cgacagtgct ggctcaggca acgtcactcg

541 ctgctttgag cattacgaga agggcagcgt gccagtcctc atcatccaca tcttcatcgt

601 gttcagcttc ttcctggtct tcctcatcat cctcttctgc aacctggtca tcatccgtac

661 cttgctcatg cagccggtgc agcagcagcg caacgctgaa gtcaagcgcc gggcgctgtg

721 gatggtgtgc acggtcttgg cggtgttcat catctgcttc gtgccccacc acgtggtgca

781 gctgccctgg acccttgctg agctgggctt ccaggacagc aaattccacc aggccattaa

841 tgatgcacat caggtcaccc tctgcctcct tagcaccaac tgtgtcttag accctgttat

901 ctactgtttc ctcaccaaga agttccgcaa gcacctcacc gaaaagttct acagcatgcg

961 cagtagccgg aaatgctccc gggccaccac ggatacggtc actgaagtgg ttgtgccatt

1021 caaccagatc cctggcaatt ccctcaaaaa ttagtccttg cttc

(2) INFORMATION FOR SEQ ID NO: 152: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1780 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 152: ttcacgaggg ctggggccag gacccagaca gagacacacg gtcactgcag ctgaagccgc

61 tgcccctgct acaggcacca ccaggaccag ctgatcattc cagcccacag caatggagcc

121 acatgactcc tcccacatgg actctgagtt ccgatacact ctcttcccga ttgtttacag

181 catcatcttt gtgctcgggg tcattgctaa tggctacgtg ctgtgggtct ttgcccgcct

241 gtacccttgc aagaaattca atgagataaa gatcttcatg gtgaacctca ccatggcgga

301 catgctcttc ttgatcaccc tgccactttg gattgtctac taccaaaacc agggcaactg

361 gatactcccc aaattcctgt gcaacgtggc tggctgcctt ttcttcatca acacctactg

421 ctctgtggcc ttcctgggcg tcatcactta taaccgcttc caggcagtaa ctcggcccat

481 caagactgct caggccaaca cccgcaagcg tggcatctct ttgtccttgg tcatctgggt

541 ggccattgtg ggagctgcat cctacttcct catcctggac tccaccaaca cagtgcccga

601 cagtgctggc tcaggcaacg tcactcgctg ctttgagcat tacgagaagg gcagcgtgcc

661 agtcctcatc atccacatct tcatcgtgtt cagcttcttc ctggtcttcc tcatcatcct

721 cttctgcaac ctggtcatca tccgtacctt gctcatgcag ccggtgcagc agcagcgcaa

781 cgctgaagtc aagcgccggg cgctgtggat ggtgtgcacg gtcttggcgg tgttcatcat

841 ctgcttcgtg ccccaccacg tggtgcagct gccctggacc cttgctgagc tgggcttcca

901 ggacagcaaa ttccaccagg ccattaatga tgcacatcag gtcaccctct gcctccttag

961 caccaactgt gtcttagacc ctgttatcta ctgtttcctc accaagaagt tccgcaagca

1021 cctcaccgaa aagttctaca gcatgcgcag tagccggaaa tgctcccggg ccaccacgga

1081 tacggtcact gaagtggttg tgeeattcaa ccagatccct ggcaattccc tcaaaaatta

1141 gtccctgctt ecaggcctga agtettetec tccatgaaac ateatgaetg agetggggga

1201 agaagggata tctactgtgg gtctgggcac cacctctgtg gcactggtgg gccattagat

1261 ttggaggcta cctcacctgg gcagggatga tgcagagcca ggctgttgga aaatccagaa

1321 ctcaaatgag ccccttcatc cgcctgtggg cgcatactac agtaactgtg actgatgact

1381 ttatcctgag tcccttaatc ttatggggcc ggaaggaatg tcagggccag gtgcagacct

1441 tgggggaaga ctttaaacca cctagttctc ccactggggc atcggtctaa agctttgggg

1501 gagtggcccc agtggctcac acctgtaatc ccagcacttt gggaggccga ggtgggcaga

1561 tcatgggtca agagatcgag acatcctggc caacattgta aaaccccatc tctactaaaa

1621 catacaaaaa ttagccgggc atggtgcaca cgcctgtagt cccagctact caggaggctg

1681 aggcaggaga atcgcttgaa cctgggaggc agaggttgca gtgaacctag attgcaccat 1741 tgcactctag cctggcaaca gaggcagatt ccctcctgcc

(2) INFORMATION FOR SEQ ID NO: 153: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1467 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 153: cgggaggcgg aggttgcggt gagctgagat cacgccactg cactccagcc tgggcagcaa

61 gagtgaaact ccatctgaaa aaaaaaaaaa gattcaacat gaacttctga ggggacatca

121 tcattctaac catggcaagg agtcttggaa ctgatgaaat ggaacagtcc cttcttgtcc

181 ctttattaac cagaattttt gtgtggtctt ccaggcacca ccaggaccag ctgatcattc

241 cagcccacag caatggagcc acatgactcc tcccacatgg actctgagtt ccgatacact

301 ctcttcccga ttgtttacag catcatcttt gtgctcgggg tcattgctaa tggctacgtg

361 ctgtgggtct ttgcccgcct gtacccttgc aagaaattca atgagataaa gatcttcatg

421 gtgaacctca ccatggcgga catgctcttc ttgatcaccc tgccactttg gattgtctac

481 taccaaaacc agggcaactg gatactcccc aaattcctgt gcaacgtggc tggctgcctt

541 ttcttcatca acacctactg ctctgtggcc ttcctgggcg tcatcactta taaccgcttc

601 caggcagtaa ctcggcccat caagactgct caggccaaca cccgcaagcg tggcatctct

661 ttgtccttgg tcatctgggt ggccattgtg ggagctgcat cctacttcct catcctggac

721 tccaccaaca cagtgcccga cagtgctggc tcaggcaacg tcactcgctg ctttgagcat

781 tacgagaagg gcagcgtgcc agtcctcatc atccacatct tcatcgtgtt cagcttcttc

841 ctggtcttcc tcatcatcct cttctgcaac ctggtcatca tccgtacctt gctcatgcag

901 ccggtgcagc agcagcgcaa cgctgaagtc acaggccggg cgctgtggat ggtgtgcacg

961 gtcttggcgg tgttcatcat ctgcttcgtg ccccaccacg tggtgcagct gccctggacc

1021 cttgctgagc tgggcttcca ggacagcaaa ttccaccagg ccattaatga tgcacatcag

1081 gtcaccctct gcctccttag caccaactgt gtcttagacc ctgttatcta ctgtttcctc

1141 accaagaagt tccgcaagca cctcaccgaa aagttctaca gcatgcgcag tagccggaaa

1201 tgctcccggg ccaccacgga tacggtcact gaagtggttg tgeeattcaa ccagatccct

1261 ggcaattccc tcaaaaatta gtccctgctt ecaggcctga agtettetec tceatgaaca

1321 tcatggactg agetggggga agaagggata tctactgtgg tetgggeace aeetetgtgg

1381 gcactggtgg gccattagat ttggaggcta cctcacctgg gcagggatga tggcagacga

1441 ggctgttgga aaatccagaa ctcaaat

(2) INFORMATION FOR SEQ ID NO: 154: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4311 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 154: ccagctgata ttccagccca cagcaatgga gccacatgac tcctcccaca tggactctga

61 gttccgatac actctcttcc cgattgttta cagcatcatc tttgtgctcg gggtcattgc

121 taatggctac gtgctgtggg tctttgcccg cctgtaccct tgcaagaaat tcaatgagat

181 aaagatcttc atggtgaacc tcaccatggc ggacatgctc ttcttgatca ccctgccact

241 ttggattgtc tactaccaaa accagggcaa ctggatactc cccaaattcc tgtgcaacgt

301 ggctggctgc cttttcttca tcaacaccta ctgctctgtg gccttcctgg gcgtcatcac

361 ttataaccgc ttccaggcag taactcggcc catcaagact gctcaggcca acacccgcaa

421 gcgtggcatc tctttgtcct tggtcatctg ggtggccatt gtgggagctg catcctactt

481 cctcatcctg gactctacca acacagtgcc cgacagtgct ggctcaggca acgtcactcg

541 ctgctttgag cattacgaga agggcagcgt gccagtcctc atcatccaca tcttcatcgt

601 gttcagcttc ttcctggtct tcctcatcat cctcttctgc aacctggtca tcatccgtac

661 cttgctcatg cagccggtgc agcagcagcg caacgctgaa gtcaagcgcc gggcgctgtg

721 gatggtgtgc acggtcttgg cggtgttcat catctgcttc gtgccccacc acgtggtgca

781 gctgccctgg acccttgctg agctgggctt ccaggacagc aaattccacc aggccattaa

841 tgatgcacat caggtcaccc tctgcctcct tagcaccaac tgtgtcttag accctgttat

901 ctactgtttc ctcaccaaga agttccgcaa gcacctcacc gaaaagttct acagcatgcg

961 cagtagccgg aaatgctccc gggccaccac ggatacggtc actgaagtgg ttgtgccatt

1021 caaccagatc cctggcaatt ccctcaaaaa ttagtccttg cttc ttcacgaggg ctggggccag gacccagaca gagacacacg gtcactgcag ctgaagccgc

61 tgcccctgct acaggcacca ccaggaccag ctgatcattc cagcccacag caatggagcc

121 acatgactcc tcccacatgg actctgagtt ccgatacact ctcttcccga ttgtttacag

181 catcatcttt gtgctcgggg tcattgctaa tggctacgtg ctgtgggtct ttgcccgcct

241 gtacccttgc aagaaattca atgagataaa gatcttcatg gtgaacctca ccatggcgga

301 catgctcttc ttgatcaccc tgccactttg gattgtctac taccaaaacc agggcaactg

361 gatactcccc aaattcctgt gcaacgtggc tggctgcctt ttcttcatca acacctactg

421 ctctgtggcc ttcctgggcg tcatcactta taaccgcttc caggcagtaa ctcggcccat

481 caagactgct caggccaaca cccgcaagcg tggcatctct ttgtccttgg tcatctgggt

541 ggccattgtg ggagctgcat cctacttcct catcctggac tccaccaaca cagtgcccga

601 cagtgctggc tcaggcaacg tcactcgctg ctttgagcat tacgagaagg gcagcgtgcc

661 agtcctcatc atccacatct tcatcgtgtt cagcttcttc ctggtcttcc tcatcatcct

721 cttctgcaac ctggtcatca tccgtacctt gctcatgcag ccggtgcagc agcagcgcaa 781 cgctgaagtc aagcgccggg cgctgtggat ggtgtgcacg gtcttggcgg tgttcatcat

841 ctgcttcgtg ccccaccacg tggtgcagct gccctggacc cttgctgagc tgggcttcca

901 ggacagcaaa ttccaccagg ccattaatga tgcacatcag gtcaccctct gcctccttag

961 caccaactgt gtcttagacc ctgttatcta ctgtttcctc accaagaagt tccgcaagca

1021 cctcaccgaa aagttctaca gcatgcgcag tagccggaaa tgctcccggg ccaccacgga

1081 tacggtcact gaagtggttg tgeeattcaa ccagatccct ggcaattccc tcaaaaatta

1141 gtccctgctt ecaggcctga agtettetec tccatgaaac ateatgaetg agetggggga

1201 agaagggata tctactgtgg gtctgggcac cacctctgtg gcactggtgg gccattagat

1261 ttggaggcta cctcacctgg gcagggatga tgcagagcca ggctgttgga aaatccagaa

1321 ctcaaatgag ccccttcatc cgcctgtggg cgcatactac agtaactgtg actgatgact

1381 ttatcctgag tcccttaatc ttatggggcc ggaaggaatg tcagggccag gtgcagacct

1441 tgggggaaga ctttaaacca cctagttctc ccactggggc atcggtctaa agctttgggg

1501 gagtggcccc agtggctcac acctgtaatc ccagcacttt gggaggccga ggtgggcaga

1561 tcatgggtca agagatcgag acatcctggc caacattgta aaaccccatc tctactaaaa

1621 catacaaaaa ttagccgggc atggtgcaca cgcctgtagt cccagctact caggaggctg

1681 aggcaggaga atcgcttgaa cctgggaggc agaggttgca gtgaacctag attgcaccat

1741 tgcactctag cctggcaaca gaggcagatt ccctcctgcc cgggaggcgg aggttgcggt gagctgagat cacgccactg cactccagcc tgggcagcaa

61 gagtgaaact ccatctgaaa aaaaaaaaaa gattcaacat gaacttctga ggggacatca

121 tcattctaac catggcaagg agtcttggaa ctgatgaaat ggaacagtcc cttcttgtcc

181 ctttattaac cagaattttt gtgtggtctt ccaggcacca ccaggaccag ctgatcattc

241 cagcccacag caatggagcc acatgactcc tcccacatgg actctgagtt ccgatacact

301 ctcttcccga ttgtttacag catcatcttt gtgctcgggg tcattgctaa tggctacgtg

361 ctgtgggtct ttgcccgcct gtacccttgc aagaaattca atgagataaa gatcttcatg

421 gtgaacctca ccatggcgga catgctcttc ttgatcaccc tgccactttg gattgtctac

481 taccaaaacc agggcaactg gatactcccc aaattcctgt gcaacgtggc tggctgcctt

541 ttcttcatca acacctactg ctctgtggcc ttcctgggcg tcatcactta taaccgcttc

601 caggcagtaa ctcggcccat caagactgct caggccaaca cccgcaagcg tggcatctct

661 ttgtccttgg tcatctgggt ggccattgtg ggagctgcat cctacttcct catcctggac

721 tccaccaaca cagtgcccga cagtgctggc tcaggcaacg tcactcgctg ctttgagcat

781 tacgagaagg gcagcgtgcc agtcctcatc atccacatct tcatcgtgtt cagcttcttc

841 ctggtcttcc tcatcatcct cttctgcaac ctggtcatca tccgtacctt gctcatgcag

901 ccggtgcagc agcagcgcaa cgctgaagtc acaggccggg cgctgtggat ggtgtgcacg

961 gtcttggcgg tgttcatcat ctgcttcgtg ccccaccacg tggtgcagct gccctggacc

1021 cttgctgagc tgggcttcca ggacagcaaa ttccaccagg ccattaatga tgcacatcag

1081 gtcaccctct gcctccttag caccaactgt gtcttagacc ctgttatcta ctgtttcctc

1141 accaagaagt tccgcaagca cctcaccgaa aagttctaca gcatgcgcag tagccggaaa

1201 tgctcccggg ccaccacgga tacggtcact gaagtggttg tgeeattcaa ccagatccct

1261 ggcaattccc tcaaaaatta gtccctgctt ecaggcctga agtettetec tceatgaaca

1321 tcatggactg agetggggga agaagggata tctactgtgg tetgggeace aeetetgtgg

1381 gcactggtgg gccattagat ttggaggcta cctcacctgg gcagggatga tggcagacga

1441 ggctgttgga aaatccagaa ctcaaat

(2) INFORMATION FOR SEQ ID NO: 155: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 827 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xι)SEQUENCE DESCRIPTION: SEQ ID NO:155: ctcctcctgc acaccttccg cacacctccc tcgctctccc acaccactgg caccaggccc

61 cgcacacctg ctcggctgca ggagaatggc tactcatcac acgctgtgga tgggactggt

121 cctgctgggg ctgctgggcg gcctacaggc agcacccgag gcccaggtct ccgtgcagcc

181 caacttccag ccggacaagt tcctggggcg ctggttcagc gcgggcctcg cctccaactc

241 gagctggctc caggagaaga aggcagcgct gtccatgtgc aagtcggtgg tggcccctgc

301 ggcggatggt ggcttcaacc tgacctccac cttcctcagg aaaaaccagt gtgagacccg

361 aaccatgctg ctgcagcccg gggactccct cggctcctac agctaccgga gtccccactg

421 gggcagcacc tactctgtgt cagtggtgga gactgactac gaccactacg ccctgctgta

481 cagccagggc agcaagggcc ccggcgagga cttccgcatg gccaccctct acagccgaac

541 ccagaccccc agggctgagt taaaggagaa atttaccgcc ttctgcaagg cccagggctt

601 cacagaggat tccattgtct tcctgcccca aaccgataag tgcatgacgg aacaatagga

661 ctccccagag ctgaagctgg gaccgcagcc agccaggtga cccctgcgat ctggatgttt

721 ccgctctgtt ccttccccga gcccctgccc cggctccccg ccaaagcacc cctgccccct

781 cgggcttcct cctggctctg cggaataaac tccggaagca agtctgt

(2) INFORMATION FOR SEQ ID NO: 156: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2245 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 156: ggagcaagag gtggttgggg ggggaccatg gctgacgttt tcccgggcaa cgactccacg

61 gcgtctcagg acgtggccaa ccgcttcgcc cgcaaagggg cgctgaggca gaagaacgtg 121 cacgaggtga aggaccacaa attcatcgcg cgcttcttca agcagcccac cttctgcagc

181 cactgcaccg acttcatctg ggggtttggg aaacaaggct tccagtgcca agtttgctgt

241 tttgtggtcc acaagaggtg ccatgaattt gttacttttt cttgtccggg tgcggataag

301 ggacccgaca ctgatgaccc caggagcaag cacaagttca aaatccacac ttacggaagc

361 cccaccttct gcgatcactg tgggtcactg ctctatggac ttatccatca agggatgaaa

421 tgtgacacct gcgatatgaa cgttcacaag caatgcgtca tcaatgtccc cagcctctgc

481 ggaatggatc acactgagaa gagggggcgg atttacctaa aggctgaggt tgctgatgaa

541 aagctccatg tcacagtacg agatgcaaaa aatctaatcc ctatggatcc aaacgggctt

601 tcagatcctt atgtgaagct gaaacttatt cctgatccca agaatgaaag caagcaaaaa

661 accaaaacca tccgctccac actaaatccg cagtggaatg agtcctttac attcaaattg

721 aaaccttcag acaaagaccg acgactgtct gtagaaatct gggactggga tcgaacaaca

781 aggaatgact tcatgggatc cctttccttt ggagtttcgg agctgatgaa gatgccggcc

841 agtggatggt acaagttgct taaccaagaa gaaggtgagt actacaacgt acccattccg

901 gaaggggacg aggaaggaaa catggaactc aggcagaaat tcgagaaagc caaacttggc

961 cctgctggca acaaagtcat cagtccctct gaagacagga aacaaccttc caacaacctt

1021 gaccgagtga aactcacgga cttcaatttc ctcatggtgt tgggaaaggg gagttttgga

1081 aaggtgatgc ttgccgacag gaagggcaca gaagaactgt atgcaatcaa aatcctgaag

1141 aaggatgtgg tgattcagga tgatgacgtg gagtgcacca tggtagaaaa gcgagtcttg

1201 gccctgcttg acaaaccccc gttcttgacg cagctgcact cctgcttcca gacagtggat

1261 cggctgtact tcgtcatgga atatgtcaac ggtggggacc tcatgtacca cattcagcaa

1321 gtaggaaaat ttaaggaacc acaagcagta ttctatgcgg cagagatttc catcggattg

1381 ttctttcttc ataaaagagg aatcatttat agggatctga agttagataa cgtcatgttg

1441 gattcagaag gacatatcaa aattgctgac tttgggatgt gcaaggaaca catgatggat

1501 ggagtcacga ccaggacctt ctgtgggact ccagattata tcgccccaga gataatcgct

1561 tatcagccgt atggaaaatc tgtggactgg tgggcctatg gcgtcctgtt gtatgaaatg

1621 cttgccgggc agcctccatt tgatggtgaa gatgaagacg agctatttca gtctatcatg

1681 gagcacaacg tttcctatcc aaaatccttg tccaaggagg ctgtttctat ctgcaaagga

1741 ctgatgacca aacacccagc caagcggctg ggctgtgggc ctgaggggga gagggacgtg

1801 agagagcatg ccttcttccg gaggatcgac tgggaaaaac tggagaacag ggagatccag

1861 ccaccattca agcccaaagt gtgtggcaaa ggagcagaga actttgacaa gttcttcaca

1921 cgaggacagc ccgtcttaac accacctgat cagctggtta ttgctaacat agaccagtct

1981 gattttgaag ggttctcgta tgtcaacccc cagtttgtgc accccatctt acagagtgca

2041 gtatgaaact caccagcgag aacaaacacc tccccagccc ccagccctcc ccgcagtgga

2101 agtgaatcct taaccctaaa attttaaggc cacggcttgt gtctgattcc atatggaggc

2161 ctgaaaattg tagggttatt agtccaaatg tgatcaactg ttcagggtct ctctcttaca

2221 accaagaaca ttatcttagt ggaag

(2) INFORMATION FOR SEQ ID NO: 157: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 636 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 157: cttatcacag ttcaagtgat ttccagaagt tccagggctt ctgagagacc atcaagggaa 61 ctttaacaac ttgacaaatg tccttgaagt aagatgcctc atctttaggg aaaaatgggg 121 tttggatttc tgcttaggca aagtctcctg cagttcatcc ttctctgtcc tcttcttgct 181 tcaggcttgg ggaccgtccc tgctgtcccc actgtggtgg caatcaggac ctaaggtgaa 241 gcaaacttga agttctatct gacaagttta ggcagtaaga gaaggaggga aatcggagca 301 aagctccctc actttattgt tgagaaactg gcatctggaa agaagaagga atttgcccaa 361 agtcagtcag ctgggataaa aacctgggtg tcctgtccag aaagtgcagg gtgctttctg 421 ctctgtagca aggcagcaga catctctgag ccaggcccac caacaggccc ttatctggtg 481 gttggatcat gatcccattt tgcttggaca tgctctcagg aagataaaaa ccatggagaa 541 acactaggcc attgacaaat gatctgagac aactttagaa aacaatgtag gatgaatgga 601 aagagaaaga aaggaaagaa aaaaaaaaaa aaaagg

(2) INFORMATION FOR SEQ ID NO: 158: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2574 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 158: cagagccggc gcaggggaag cgcccggggc cccgggtgca gcagcgcccg ccgcctcccg

61 ggcctccccg gcccgcagcc cggggtcccg ggccccgggg ccggcacctc tcgggctccg 121 gctccccgcg cgcaagatgg ctgacccggc tgcggggccg ccgccgagcg agggcgagga 181 gagcaccgtg cgcttcgccc gcaaaggcgc cctccggcag aagaacgtgc atgaggtcaa 241 gaaccacaaa ttcaccgccc gcttcttcaa gcagcccacc ttctgcagcc actgcaccga 301 cttcatctgg ggcttcggga agcagggatt ccagtgccaa gtttgctgct ttgtggtgca 361 caagcggtgc catgaatttg tcacattctc ctgccctggc gctgacaagg gtccagcctc 421 cgatgacccc cgcagcaaac acaagtttaa gatccacacg tactccagcc ccacgttttg 481 tgaccactgt gggtcactgc tgtatggact catccaccag gggatgaaat gtgacacctg 541 catgatgaat gtgcacaagc gctgcgtgat gaatgttccc agcctgtgtg gcacggacca 601 cacggagcgc cgcggccgca tctacatcca ggcccacatc gacagggacg tcctcattgt 661 cctcgtaaga gatgctaaaa accttgtacc tatggacccc aatggcctgt cagatcccta

721 cgtaaaactg aaactgattc ccgatcccaa aagtgagagc aaacagaaga ccaaaaccat

781 caaatgctcc ctcaaccctg agtggaatga gacatttaga tttcagctga aagaatcgga

841 caaagacaga agactgtcag tagagatttg ggattgggat ttgaccagca ggaatgactt

901 catgggatct ttgtcctttg ggatttctga acttcagaag gccagtgttg atggctggtt

961 taagttactg agccaggagg aaggcgagta cttcaatgtg cctgtgccac cagaaggaag

1021 tgaggccaat gaagaactgc ggcagaaatt tgagagggcc aagatcagtc agggaaccaa

1081 ggtcccggaa gaaaagacga ccaacactgt ctccaaattt gacaacaatg gcaacagaga

1141 ccggatgaaa ctgaccgatt ttaacttcct aatggtgctg gggaaaggca gctttggcaa

1201 ggtcatgctt tcagaacgaa aaggcacaga tgagctctat gctgtgaaga tcctgaagaa

1261 ggacgttgtg atccaagatg atgacgtgga gtgcactatg gtggagaagc gggtgttggc

1321 cctgcctggg aagccgccct tcctgaccca gctccactcc tgcttccaga ccatggaccg

1381 cctgtacttt gtgatggagt acgtgaatgg gggcgacctc atgtatcaca tccagcaagt

1441 cggccggttc aaggagcccc atgctgtatt ttacgctgca gaaattgcca tcggtctgtt

1501 cttcttacag agtaagggca tcatttaccg tgacctaaaa cttgacaacg tgatgctcga

1561 ttctgaggga cacatcaaga ttgccgattt tggcatgtgt aaggaaaaca tctgggatgg

1621 ggtgacaacc aagacattct gtggcactcc agactacatc gcccccgaga taattgctta

1681 tcagccctat gggaagtccg tggattggtg ggcatttgga gtcctgctgt atgaaatgtt

1741 ggctgggcag gcaccctttg aaggggagga tgaagatgaa ctcttccaat ccatcatgga

1801 acacaacgta gcctatccca agtctatgtc caaggaagct gtggccatct gcaaagggct

1861 gatgaccaaa cacccaggca aacgtctggg ttgtggacct gaaggcgaac gtgatatcaa

1921 agagcatgca tttttccggt atattgattg ggagaaactt gaacgcaaag agatccagcc

1981 cccttataag ccaaaagcta gagacaagag agacacctcc aacttcgaca aagagttcac

2041 cagacagcct gtggaactga cccccactga taaactcttc atcatgaact tggaccaaaa

2101 tgaatttgct ggcttctctt atactaaccc agagtttgtc attaatgtgt aggtgaatgc

2161 aaactccatc gttgagcctg gggtgtaaga cttcaagcca agcgtatgta tcaattctag

2221 tcttccagga ttcacggtgc acatgctggc attcaacatg tggaaagctt gtcttagagg

2281 cctttcttgt atgtgtagct tgctagtttg ttttctacat ttgaaaatgt ttagtttaga

2341 ataagcgcat tatccaatta tagaggtaca attttccaaa cttccagaaa ctcatcaaat

2401 gaacagacaa tgtcaaaact actgtgtctg ataccaaaat gcttcagtat ttgtaatttt

2461 tcaagtcaga agctgatgtt cctggtaaaa gtttttacag ttattctata atatcttctt

2521 tgaatgctaa gcatgagcga tatttttaaa aattgtgagt aagcttcgga attc

(2) INFORMATION FOR SEQ ID NO: 159: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3321 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xι)SEQUENCE DESCRIPTION: SEQ ID NO:159: cagagccggc gcaggggaag cgcccggggc cccgggtgca gcagcgcccg ccgcctcccg

61 ggcctccccg gcccgcagcc cggggtcccg ggccccgggg ccggcacctc tcgggctccg 121 gctccccgcg cgcaagatgg ctgacccggc tgcggggccg ccgccgagcg agggcgagga 181 gagcaccgtg cgcttcgccc gcaaaggcgc cctccggcag aagaacgtgc atgaggtcaa 241 gaaccacaaa ttcaccgccc gcttcttcaa gcagcccacc ttctgcagcc actgcaccga 301 cttcatctgg ggcttcggga agcagggatt ccagtgccaa gtttgctgct ttgtggtgca 361 caagcggtgc catgaatttg tcacattctc ctgccctggc gctgacaagg gtccagcctc 421 cgatgacccc cgcagcaaac acaagtttaa gatccacacg tactccagcc ccacgttttg 481 tgaccactgt gggtcactgc tgtatggact catccaccag gggatgaaat gtgacacctg 541 catgatgaat gtgcacaagc gctgcgtgat gaatgttccc agcctgtgtg gcacggacca 601 cacggagcgc cgcggccgca tctacatcca ggcccacatc gacagggacg tcctcattgt 661 cctcgtaaga gatgctaaaa accttgtacc tatggacccc aatggcctgt cagatcccta 721 cgtaaaactg aaactgattc ccgatcccaa aagtgagagc aaacagaaga ccaaaaccat

7 1 caaatgctcc ctcaaccctg agtggaatga gacatttaga tttcagctga aagaatcgga 841 caaagacaga agactgtcag tagagatttg ggattgggat ttgaccagca ggaatgactt 901 catgggatct ttgtcctttg ggatttctga acttcagaag gccagtgttg atggctggtt 961 taagttactg agccaggagg aaggcgagta cttcaatgtg cctgtgccac cagaaggaag 1021 tgaggccaat gaagaactgc ggcagaaatt tgagagggcc aagatcagtc agggaaccaa 1081 ggtcccggaa gaaaagacga ccaacactgt ctccaaattt gacaacaatg gcaacagaga 1141 ccggatgaaa ctgaccgatt ttaacttcct aatggtgctg gggaaaggca gctttggcaa 1201 ggtcatgctt tcagaacgaa aaggcacaga tgagctctat gctgtgaaga tcctgaagaa 1261 ggacgttgtg atccaagatg atgacgtgga gtgcactatg gtggagaagc gggtgttggc 1321 cctgcctggg aagccgccct tcctgaccca gctccactcc tgcttccaga ccatggaccg 1381 cctgtacttt gtgatggagt acgtgaatgg gggcgacctc atgtatcaca tccagcaagt 1441 cggccggttc aaggagcccc atgctgtatt ttacgctgca gaaattgcca tcggtctgtt 1501 cttcttacag agtaagggca tcatttaccg tgacctaaaa cttgacaacg tgatgctcga 1561 ttctgaggga cacatcaaga ttgccgattt tggcatgtgt aaggaaaaca tctgggatgg 1621 ggtgacaacc aagacattct gtggcactcc agactacatc gcccccgaga taattgctta 1681 tcagccctat gggaagtccg tggattggtg ggcatttgga gtcctgctgt atgaaatgtt 1741 ggctgggcag gcaccctttg aaggggagga tgaagatgaa ctcttccaat ccatcatgga 1801 acacaacgta gcctatccca agtctatgtc caaggaagct gtggccatct gcaaagggct 1861 gatgaccaaa cacccaggca aacgtctggg ttgtggacct gaaggcgaac gtgatatcaa 1921 agagcatgca tttttccggt atattgattg ggagaaactt gaacgcaaag agatccagcc

1981 cccttataag ccaaaagctt gtgggcgaaa tgctgaaaac ttcgaccgat ttttcacccg

2041 ccatccacca gtcctaacac ctcccgacca ggaagtcatc aggaatattg accaatcaga

2101 attcgaagga ttttcctttg ttaactctga atttttaaaa cccgaagtca agagctaagt

2161 agatgtgtag atctccgtcc ttcatttctg tcattcaagc tcaacggcta ttgtggtgac

2221 atttttatgt ttttcattgc caagttgcat ccatgtttga ttttctgatg agactagagt

2281 gacagtgttt cagaacccaa atgtcctcag gtagtttgga gcatctctat gagatgggat

2341 tatgcagatg gcctatggaa aatgcagctg cataattaac acattatcaa agtcctctta

2401 caatttattt tccgcagcat gtcagctaag tagacccaat ggggagagaa aatgcctgct

2461 ttctttccct ctttttctgc actgccatat tcacccccaa ccatccaatc tgtggataat

2521 tggatgttag cggtactctt ccacttccgg tcctggagct tggcttgtat ccaagtgtat

2581 ggttgctttg cctaagagga atccctctat ttcacctgtt ctggaggcac cagaccttga

2641 aaagaacatg ctcaaaataa aatgttatct gttatttttg taaactcaaa gttaagatga

2701 tcaaagttct aaaattccaa gaatgtgctt ttagacggtc tcaatctaaa agcacttcaa

2761 ggggtcaaag ggcaaccagc ttggtgctac ctcagtgttg tagtttctga tactttatgt

2821 ctttgctcac cctcatcccc aaactacttg aaaagggcat ttggcaccac tctctgaaac

2881 aacacagtca ctctagcaag gcccccaaag ggccctggtt ttacattaca tttcaaactt

2941 tatttgcttt ggggttttgt ttctgttgtt gttcaaatgc aaaaaaaaga aaaaaaaaag

3001 aaaaaaaaag gtgactcaca ttgttacaca tgctttaaaa tatgtgttca aatgttatta

3061 accacaatga cgacctgttt tgatttaacc aagaagacgg ctgcggagcc tagcagactc

3121 aggcctgtgg gaatgggatt tgttacaaat ctaggtttgt tactggcttc agaaagctaa

3181 ttaagtgctc tgaaaaagac accgtttctt gaaacaaaga tggttgtatt cctcactttg

3241 atgttgtttt gcaagatgtt tgtggaaatg ttcatttgta tctggatctc tgttatgtgc

3301 catttttctt ctagcatcga g

(2) INFORMATION FOR SEQ ID NO: 160: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 621 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 160: gtccttcatt ccttccacaa ctatttatcc agcaccgttt ctgggcacag ggctccagcg

61 atggtcccaa caggtacaat gacctctggg gaccaagttc agttcttggt gagttctcca 121 gtgcctctcg atgtaggatg aaccgttggc atgctccact gacgctggct ccttctgttg 181 tttctcttgg ctccaggacc cccgcagcaa acacaagttt aagatccaca cgtactccag 241 ccccacgttt tgtgaccact gtgggtcact gctgtatgga ctcatccacc aggggatgaa 301 atgtgacagt aagtactttc tctctctggg ggcatctgct gatggcagaa gcaatgggaa 361 gggctgcttc cacttggttt ggggtccagg tctgccatac attcccccct gtcctcgttg 421 gggctggtgt accagttatc tgttgctgca taatgatcct cccaccccaa aacactgtga 481 ctgaagacaa taaacatttt tttagctcat gactctgcaa ggcagtcctt tgaatctggg 541 ctggcctcag ctgatgtcac gcatgttcat aaagcatgaa ctcatggttc atggtggatt 601 agcagatgga ggtgggctgg g

(2) INFORMATION FOR SEQ ID NO: 161: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1559 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 161: acatcaagga gacgagtcct ggttggatag taatgtcttt aacacccctc tagcatttat

61 taatttcctc tcttaacaaa taaaagatgc ccttcagtca gatgcttagg acagatgacg

121 cacctagaga tattttaata atgtagatac tcttgctgtt caaactcaga ccaaaatgac

181 gataggcttt tttggccccc agagggtgca caaatacgac cagaatttgt gaagacgagt

241 cagaaatgaa tgaaatttgg aaaaatattg atctactgaa atccttcctc cccacactat

301 tagccctatg ttacagttgg ggaaacggag tcgttttgca gaggggatgg acagaaggta

361 gggagttctc ttccaaacgt gcaggaggca agcaaagcca agaatcttct ctgtggtgag

421 ttagagacat ataaaataaa gatcgctcct cccctacctc tgcagaacgt gtgtgtgtat

481 gtgtgtgtaa gtgtgtgcgg ccacaagcct ttccgaatga gtgacagcgg gagcccatcc

541 ctccaggaga cgcgtgcaga atgaccaatg ggatggatgg gggtggatgg gtaccagtct

601 ccgcagaggc cggggtggga attcgctgcg ccccacccct tccacccgct ccccttcgcc

661 ccgtaggtct ttccactctc gctcctcccc tgggcacatc tcctgaacgc agccccgggg

721 gccgaggacg gggtggggtg gggggcgagg ctcgggtccg acgaccccgg gctgcggtcc

781 cggcgctgca gagctgcggc tgtgcacgct tagccgcgag gcccgcggta gcccgggcgc

841 cgatatgtaa agcagctggc agcgctgggc ggggcctggg cgcgactgca aatgaggagg

901 gcgcgggctg gcccgggggc tccgcctccc tcccccgcag ctggggccag cggctgccaa

961 gcgcactggt cgagcggcag cagctgggcg aggtgacagc cccggctccg cgcgccggcc

1021 gccagagccg gcgcagggga agcgcccgcg gccccgggtg cagcagcggc cgccgcctcc

1081 cgcgcctccc cggcccgcag cccgcggtcc cgcgccccgg ggccggcacc tctcgggctc

1141 cggctccccg cgcgcaaαat ggctgacccg gctgcggggc cgccgccgag cgagggcgag 1201 gagagcaccg tgcgcttcgc ccgcaaaggc gccctcaggc agaagaacgt gcatgaggtc

1261 aagaaccaca aattcaccgc ccgcttcttc aagcagccca ccttctgcag ccactgcacc

1321 gacttcatct ggtgaccccc caggcactcc ggccccaggc cacgccgcgc caggaccccc

1381 tctccgcgcc ctctgcgccc tccgcaccct ggaccccgcg tccccggact ccccgctccg

1441 gaccctgctg cccgggactc ccggatggac agtcctagcc gttgccctgt ccccaccctg

1501 gtcccagacg ggccgccgcg ggcgcctcct gccctctcct gctctcaggc gcctctaga

(2) INFORMATION FOR SEQ ID NO: 162: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2510 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 162: gtcgactgca ggtcaacgga cacatcaagg agagagtcct ggttggatag taatgtcttt

61 aacacccctc tagcatttat taatttcctc tcttaacaaa taaaagatga cttcagttga

121 agatccttag gacagatgac ggcacctgga gatattttaa taatgtagat accctcttgc

181 tgttcaaact cagaccaaaa gagatggctt tttttccccc agagggtgca caaatacgac

241 agaatttgtg aagacgagtc agaaatgaat gaaatttgga aaaatattga tctactgaaa

301 tccttcctcc ccacactatt agccctatgt tacagttggg gaaacggagt cgttttgcag

361 aggggatgga cagaaggtag ggagttctct tccaacgtgc aggaggcaag caaagccaag

421 catcttctct gtggtggagt tagagacata taaaataaga tcgctcctcc cctacctctg

481 cagaacgtgt gtgtgtatgt gtgtgtaacg tgtgtgcggc cacaagcctt tccgaatgag

541 tgacagcggg agcccatccc tccaggagac gcgtgcagaa tgaccaatgg gatggatggg

601 ggtggatggg taccgtctcc gcgaggccgg ggtggaattc gctgcgcccc accccttcca

661 cccgctcccc ttcgccccgt aggtctttcc actctcgctc ctcccctggg cacatctcct

721 gaacgcagcc ccgggggccg aggacggggt ggggtggggg gcgaggctcg ggtccgacga

781 ccccgggctg cggtcccggc gctgcagagc tgcggctgtg cacgcttagc cgcgaggccc

841 gcggtagccc gggcgccgat atgtaaagca gctggcagcg ctgggcgggg cctgggcgcg

901 atgcaaatga ggagggcggg gctggcccgg ggctccgcct ccctcccccg cagctggggc

961 cagcggtgcc aagcgcagct ggacgagcgg cagcagctgg gcgagtgaca gccccggctc

1021 cgcgcgccgc ggccgccaga gccggcgcag gggaagcgcc cgcggccccg ggtgcagcag

1081 cggccgccgc ctcccgcgcc tccccggccc gcagcccgcg gtcccgcggc cccggggccg

1141 gcacctctcg ggctccggct ccccgcgcgc aagatggctg acccggctgc ggggccgccg

1201 ccgagcgagg gcgaggagag caccgtgcgc ttcgcccgca aaggcgccct caggcagaag

1261 aacgtgcatg aggtcaagaa ccacaaattc accgcccgct tcttcaagca gcccaccttc

1321 tgcagccact gcaccgactt catctggtgg agcgcgcgcg caaggcacct tcccgggccc

1381 ccgaggcagc gccgcgccaa gggaccccct ctccgccctc tgcgccctcc gcaccctgga

1441 ccccgcgtcc ccggactccc cgctccggac cctgctgccg ggactcccgg atggacagtc

1501 ctgccgttgc cctgtcccca ccctggtccc aggacggggg cgcctcctgc cctctcctgc

1561 tctcaggcgc ctctagagcg cccaggggca gcgtcgcggg cgcctttgct ccacctgact

1621 aggagcgcgc ggggtctgtg cctgccctgg agggcagcgc ctcgggtgct ctccgacccg

1681 gggttcccta tctctccgcc tgcttccggg cgcgaggagc cctcgccccc caccccttgt

1741 ttccgggggg ggggggcggc gccctgggtg tccttctcta tctctgcggg catgggacat

1801 cctttctcac tcctctgtgc ctcggcagcg ccctgtgtta tctcccattg ccctccccga

1861 gggcctggtt cccctttcca ctcctcggtc acatcactgc gggccccttt cttccccagt

1921 ccctccagta gtggggcatc ctttcctcct tcccagtccc cctcccagag gacaccaccg

1981 ccgcggggtc actctcgccc tccctctgaa tgcgtcttta tctcttctct tttccgaggg

2041 tgctcggggc atctatgggt acatctgtcg cctgccttca gcccctaccc cgacggaaac

2101 gctccccact atcccgccac ctggtggtcg cagcctcctc tcttctgcag gagtgaaggc

2161 agatcggggt tacagccgag ctcccaccta cccccacaaa ggcggaagac tcttgggcac

2221 ccgcctgtgg ctgggagttt gcacctgggg tacagaggca gggaggaagg cgggtgactc

2281 tgtgggtaac tagctggagg ctgggccccc gggctgcctg acatacacct ccttctgctt

2341 ttgcaggggc ttcgggaagc agggattcca gtgccaaggt aggctctggg gctttgggga

2401 tgctatttgt gggaagagag ggtgaaaaat actttataga agaagttact gagttaggca

2461 gagagtgaaa gaatcacgtt ggtcggagtg acctcccagg ctaggaattc

(2) INFORMATION FOR SEQ ID NO: 163: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2163 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 163: aaagcgacca tgtatcctga gtggaagtcg acgttcgatg cccacateta tgaggggcgc 61 gtcatccaga ttgtgctaat gcgggcagca gaggagccag tgtctgaggt gaccgtgggt 121 gtgtcggtgc tggccgagcg ctgcaagaag aacaatggca aggctgagtt ctggctggac 181 ctgcagcctc aggccaaggt gttgatgtct gttcagtatt tcctggagga cgtggattgc 241 aaacagtcta tgcgcagtga ggacgaggcc aagttcccaa cgatgaaccg ccgcggagcc 301 atcaaacagg ccaaaatcca ctacatcaag aaccatgagt ttatcgccac cttctttggg 361 caacccacct tctgttctgt gtgcaaagac tttgtctggg gcctcaacaa gcaaggctac 421 aaatgcaggc aatgtaacgc tgccatccac aagaaatgca tcgacaagat catcggcaga 481 tgcactggca ccgcggccaa cagccgggac actatattcc agaaagaacg cttcaacatc 541 gacatgccgc accgcttcaa ggttcacaac tacatgagcc ccaccttctg tgaccactgc

601 ggcagcctgc tctggggact ggtgaagcag ggattaaagt gtgaagactg cggcatgaat

661 gtgcaccata aatgccggga gaaggtggcc aacctctgcg gcatcaacca gaagcttttg

721 gctgaggcct tgaaccaagt cacccagaga gcctcccgga gatcagactc agcctcctca

781 gagcctgttg ggatatatca gggtttcgag aagaagaccg gagttgctgg ggaggacatg

841 caagacaaca gtgggaccta cggcaagatc tgggagggca gcagcaagtg caacatcaac

901 aacttcatct tccacaaggt cctgggcaaa ggcagcttcg ggaaggtgct gcttggagag

961 ctgaagggca gaggagagta ctttgccatc aaggccctca agaaggatgt ggtcctgatc

1021 gacgacgacg tggagtgcac catggttgag aagcgggtgc tgacacttgc cgcagagaat

1081 ccctttctca cccacctcat ctgcaccttc cagaccaagg accacctgtt ctttgtgatg

1141 gagttcctca acggggggga cctgatgtac cacatccagg acaaaggccg ctttgaactc

1201 taccgtgcca cgttttatgc cgctgagata atgtgtggac tgcagtttct acacagcaag

1261 ggcatcattt acagggacct caaactggac aatgtgctgt tggaccggga tggccacatc

1321 aagattgccg actttgggat gtgcaaagag aacatattcg gggagagccg ggccagcacc

1381 ttctgcggca cccctgacta tatcgcccct gagatcctac agggcctgaa gtacacattc

1441 tctgtggact ggtggtcttt cggggtcctt ctgtacgaga tgctcattgg ccagtccccc

1501 ttccatggtg atgatgagga tgaactcttc gagtccatcc gtgtggacac gccacattat

1561 ccccgctgga tcaccaagga gtccaaggac atcctggaga agctctttga aagggaacca

1621 accaagaggc tgggagtgac gggaaacatc aaaatccacc ccttcttcaa gaccataaac

1681 tggactctgc tggaaaagcg gaggttggag ccacccttca ggcccaaagt gaagtcaccc

1741 agagactaca gtaactttga ccaggagttc ctgaacgaga aggcgcgcct ctcctacagc

1801 gacaagaacc tcatcgactc catggaccag tctgcattcg ctggcttctc ctttgtgaac

1861 cccaaattcg agcacctcct ggaagattga ggttcctgga cagatcaggc tagccctgcc

1921 ctccacccac acctgcccgc tccccacgat aagcaccagt gggactgtgg tgacttctgc

1981 tgctggcccc gcccctgccc ccagagcgtc cttggctgcc gtctggccgg gctctcatgg

2041 tacttcctct gtgaactgtg tgtgaatctg cttttcctct gccttcggag ggaaattgta

2101 aatcctgtgt ttcattactt gaatgtagtt atctattgaa aatatacttt agagcacaat

2161 gga

(2) INFORMATION FOR SEQ ID NO: 164: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2104 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 164: tgccgccgcg acccttggcg cctgcccctg caacgggagc cccactgcag gccccaccat

61 ggcgccgttc ctgcgcatcg ccttcaactc ctatgagctg ggctccctgc aggccgagga

121 cgaggcgaac cagcccttct gtgccgtgaa gatgaaggag gcgctcagca cagagcgtgg

181 gaaaacactg gtgcagaaga agccgaccat gtatcctgag tggaagtcga cgttcgatgc

241 ccacatctat gaggggcgcg tcatccagat tgtgctaatg cgggcagcag aggagccagt

301 gtctgaggtg accgtgggtg tgtcggtgct ggccgagcgc tgcaagaaga acaatggcaa

361 ggctgagttc tggctggacc tgcagcctca ggccaaggtg ttgatgtctg ttcagtattt

421 cctggaggac gtggattgca aacaatctat gcgcagtgag gacgaggcca agttcccaac

481 gatgaaccgc cgcggagcca tcaaacaggc caaaatccac tacatcaaga accatgagtt

541 tatcgccacc ttctttgggc aacccacctt ctgttctgtg tgcaaagact ttgtctgggg

601 cctcaacaag caaggctaca aatgcaggca atgtaacgct gccatccaca agaaatgcat

661 cgacaagatc atcggcagat gcactggcac cgcggccaac agccgggaca ctatattcca

721 gaaagaacgc ttcaacatcg acatgccgca ccgcttcaag gttcacaact acatgagccc

781 caccttctgt gaccactgcg gcagcctgct ctggggactg gtgaagcagg gattaaagtg

841 tgaagactgc ggcatgaatg tgcaccataa atgccgggag aaggtggcca acctctgcgg

901 catcaaccag aagcttttgg ctgaggcctt gaaccaagtc acccagagag cctcccggag

961 atcagactca gcctcctcag agcctgttgg gatatatcag ggtttcgaga agaagaccgg

1021 agttgctggg gaggacatgc aagacaacag tgggacctac ggcaagatct gggagggcag

1081 cagcaagtgc aacatcaaca acttcatctt ccacaaggtc ctgggcaaag gcagcttcgg

1141 gaaggtgctg cttggagagc tgaagggcag aggagagtac tctgccatca aggccctcaa

1201 gaaggatgtg gtcctgatcg acgacgacgt ggagtgcacc atggttgaga agcgggtgct

1261 gacacttgcc gcagagaatc cctttctcac ccacctcatc tgcaccttcc agaccaagga

1321 ccacctgttc tttgtgatgg agttcctcaa cgggggggac ctgatgtacc acatccagga

1381 caaaggccgc tttgaactct accgtgccac gttttatgcc gctgagataa tgtgtggact

1441 gcagtttcta cacagcaagg gcatcattta cagggacctc aaactggaca atgtgctgtt

1501 ggaccgggat ggccacatca agattgccga ctttgggatg tgcaaagaga acatattcgg

1561 ggagagccgg gccagcacct tctgcggcac ccctgactat atcgcccctg agatcctaca

1621 gggcctgaag tacacattct ctgtggactg gtggtctttc ggggtccttc tgtacgagat

1681 gctcattggc cagtccccct tccatggtga tgatgaggat gaactcttcg agtccatccg

1741 tgtggacacg ccacattatc cccgctggat caccaaggag tccaaggaca tcctggagaa

1801 gctctttgaa agggaaccaa ccaagaggct gggaatgacg ggaaacatca aaatccaccc

1861 cttcttcaag accataaact ggactctgct ggaaaagcgg aggttggagc cacccttcag

1921 gcccaaagtg aagtcaccca gagactacag taactttgac caggagttcc tgaacgagaa

1981 ggcgcgcctc tcctacagcg acaagaacct catcgactcc atggaccaat ctgcattcgc

2041 tggcttctcc tttgtgaacc ccaaattcga gcacctcctg gaagattgag gttcctggac

2101 agat (2) INFORMATION FOR SEQ ID NO: 165: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2146 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 165: cccaagatgg aagggagcgg cggccgcgtc cgcctcaagg cgcattacgg gggggacatc

61 ttcatcacca gcgtggacgc cgccacgacc ttcgaggagc tctgtgagga agtgagagac

121 atgtgtcgtc tgcaccagca gcacccgctc accctcaagt gggtggacag cgaaggtgac

181 ccttgcacgg tgtcctccca gatggagctg gaagaggctt tccgcctggc ccgtcagtgc

241 agggatgaag gcctcatcat tcatgttttc ccgagcaccc ctgagcagcc tggcctgcca

301 tgtccgggag aagacaaatc tatctaccgc cggggagcca gaagatggag gaagctgtac

361 cgtgccaacg gccacctctt ccaagccaag cgctttaaca ggagagcgta ctgcggtcag

421 tgcagcgaga ggatatgggg cctcgcgagg caaggctaca ggtgcatcaa ctgcaaactg

481 ctggtccata agcgctgcca cggcctcgtc ccgctgacct gcaggaagca tatggattct

541 gtcatgcctt cccaagagcc tccagtagac gacaagaacg aggacgccga ccttccttcc

601 gaggagacag atggaattgc ttacatttcc tcatcccgga agcatgacag cattaaagac

661 gactcggagg accttaagcc agttatcgat gggatggatg gaatcaaaat ctctcagggg

721 cttgggctgc aggactttga cctaatcaga gtcatcgggc gcgggagcta cgccaaggtt

781 ctcctggtgc ggttgaagaa gaatgaccaa atttacgcca tgaaagtggt gaagaaagag

841 ctggtgcatg atgacgagga tattgactgg gtacagacag agaagcacgt gtttgagcag

901 gcatccagca accccttcct ggtcggatta cactcctgct tccagacgac aagtcggttg

961 ttcctggtca ttgagtacgt caacggcggg gacctgatgt tccacatgca gaggcagagg

1021 aagctccctg aggagcacgc caggttctac gcggccgaga tctgcatcgc cctcaacttc

1081 ctgcacgaga gggggatcat ctacagggac ctgaagctgg acaacgtcct cctggatgcg

1141 gacgggcaca tcaagctcac agactacggc atgtgcaagg aaggcctggg ccctggtgac

1201 acaacgagca ctttctgcgg aaccccgaat tacatcgccc ccgaaatcct gcggggagag

1261 gagtacgggt tcagcgtgga ctggtgggcg ctgggagtcc tcatgtttga gatgatggcc

1321 gggcgctccc cgttcgacat catcaccgac aacccggaca tgaacacaga ggactacctt

1381 ttccaagtga tcctggagaa gcccatccgg atcccccggt tcctgtccgt caaagcctcc

1441 catgttttaa aaggattttt aaataaggac cccaaagaga ggctcggctg ccggccacag

1501 actggatttt ctgacatcaa gtcccacgcg ttcttccgca gcatagactg ggacttgctg

1561 gagaagaagc aggcgctccc tccattccag ccacagatca cagacgacta cggtctggac

1621 aactttgaca cacagttcac cagcgagccc gtgcagctga ccccagacga tgaggatgcc

1681 ataaagagga tcgaccagtc agagttcgaa ggctttgagt atatcaaccc attattgctg

1741 tccaccgagg agtcggtgtg aggccgcgtg cgtctctgtc gtggacacgc gtgattgacc

1801 ctttaactgt atccttaacc accgcatatg catgccaggc tgggcacggc tccgagggcg

1861 gccagggaca gacgcttgcg ccgagaccgc agagggaagc gtcagcgggc gctgctggga

1921 gcagaacagt ccctcacacc tggcccggca ggcagcttcg tgctggagga acttgctgct

1981 gtgcctgcgt cgcggcggat ccgcggggac cctgccgagg gggctgtcat gcggtttcca

2041 aggtgcacat tttccacgga aacagaactc gatgcactga cctgctccgc caggaaagtg

2101 agcgtgtagc gtcctgagga ataaaatgtt ccgatgaaaa aaaaaa

(2) INFORMATION FOR SEQ ID NO: 166: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1423 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 166: gggccggcgg cggcggcgac tctggacgcg agccgggccc ttcccgtgga tcgccccagc

61 tgcggcgggc gtcgcggccg cccccgggtg gcacttccgt gtgccgcggc gccggagccc 121 gaggcggctg tagcccacat ctcccgagcg acccccggcg cccgcccgcc gcgcggaggc 181 ccgggccaca cctcactggc cgcttggccc atcccagtca gcgccgcgcc gaaccccgtc 241 cgcgcgcgcc ggggagcggc gcccccgccg ctgccgccgc gacccttggc gcctgcccct 301 gcaacgggag ccccactgca ggccccacca tggcgccgtt cctgcgcatc gccttcaact 361 cctatgagct gggctccctg caggccgagg acgaggcgaa ccagcccttc tgtgccgtga 421 agatgaagga ggcgctcagc acagagcgtg ggaaaacact ggtgcagaag aagccgacca 481 tgtatcctga gtggaagtcg acgttcgatg cccacatcta tgaggggcgc gtcatccaga 541 ttgtgctaat gcgggcagca gaggagccag tgtctgaggt gaccgtgggt gtgtcggtgc 601 tggccgagcg ctgcaagaag aacaatggca aggctgagtt ctggctggac ctgcagcctc 661 aggccaaggt gttgatgtct gttcagtatt tcctggagga cgtggattgc aaacagtcta 721 tgcgcagtga ggacgaggcc aagttcccaa cgatgaaccg ccgcggagcc atcaaacagg 781 ccaaaatcca ctacatcaag aaccatgagt ttatcgccac cttctttggg caacccacct 841 tctgttctgt gtgcaaagac tttgtctggg gcctcaacaa gcaaggctac aaatgcaggc 901 aatgtaacgc tgccatccac aagaaatgca tcgacaagat catcggcaga tgcactggca 961 ccgcggccaa cagccgggac actatattcc agaaagaacg cttcaacatc gacatgccgc 1021 accgcttcaa ggttcacaac tacatgagcc ccaccttctg tgaccactgc ggcagcctgc 1081 tctggggact ggtgaagcag ggattaaagt gtgaagactg cggcatgaat gtgcaccata 1141 aatgccggga gaaggtggcc aacctctgcg gcatcaacca gaagcttttg gctgaggcct

1201 tgaaccaagt cacccagaga gcctcccgga gatcagactc agcctcctca gagcctgttg

1261 ggatatatca gggtttcgag aagaagaccg gagttgctgg ggaggacatg caagacaaca

1321 gtgggaccta cggcaagatc tgggagggca gcagcaagtg caacatcaac aacttcatct

1381 tccacaaggt cctgggcaaa ggcagcttcg ggaaggtgct get

(2) INFORMATION FOR SEQ ID NO: 167: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2244 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi (SEQUENCE DESCRIPTION: SEQ ID NO: 167: ctccccgccc cgaccatggt agtgttcaat ggccttctta agatcaaaat ctgcgaggcc

61 gtgagcttga agcccacagc ctggtcgctg cgccatgcgg tgggaccccg gccgcagact

121 ttccttctcg acccctacat tgccctcaat gtggacgact cgcgcatcgg ccaaacggcc

181 accaagcaga agaccaacag cccggcctgg cacgacgagt tcgtcaccga tgtgtgcaac

241 ggacgcaaga tcgagctggc tgtctttcac gatgccccca taggctacga cgacttcgtg

301 gccaactgca ccatccagtt tgaggagctg ctgcagaacg ggagccgcca cttcgaggac

361 tggattgatc tggagccaga aggaagagtg tatgtgatca tcgatctctc agggtcgtcg

421 ggtgaagccc ctaaagacaa tgaagagcgt gtgttcaggg aacgcatgcg gccgaggaag

481 cggcaggggg ccgtcaggcg cagggtccat caggtcaacg gccacaagtt catggccacc

541 tatcttcggc agcccaccta ctgctcccat tgcagagact tcatctgggg tgtcatagga

601 aagcagggat accagtgtca agtctgcacc tgcgtggtcc acaagcggtg ccacgagctc

661 ataatcacaa agtgtgctgg gttaaagaag caggagaccc ccgaccaggt gggctcccag

721 cggttcagcg tcaacatgcc ccacaagttc ggtatccaca actacaaggt ccctaccttc

781 tgcgatcact gtgggtccct gctctgggga ctcttgcggc agggtttgca gtgtaaagtc

841 tgcaaaatga atgttcaccg tcgatgtgag accaacgtgg ctcccaactg tggagtggat

901 gccagaggaa tcgccaaagt actggccgac ctgggcgtta ccccagacaa aatcaccaac

961 agcggccaga gaaggaaaaa gctcattgct ggtgccgagt ccccgcagcc tgcttctgga

1021 agctcaccat ctgaggaaga tcgatccaag tcagcaccca cctccccttg tgaccaggaa

1081 ataaaagaac ttgagaacaa cattcggaaa gccttgtcat ttgacaaccg aggagaggag

1141 caccgggcag catcgtctcc tgatggccag ctgatgagcc ccggtgagaa tggcgaagtc

1201 cggcaaggcc aggccaagcg cctgggcctg gatgagttca acttcatcaa ggtgttgggc

1261 aaaggcagct ttggcaaggt catgttggca gaactcaagg gcaaagatga agtatatgct

1321 gtgaaggtct taaagaagga cgtcatcctt caggatgatg acgtggactg cacaatgaca

1381 gagaagagga ttttggctct ggcacggaaa cacccgtacc ttacccaact ctactgctgc

1441 ttccagacca aggaccgcct ctttttcgtc atggaatatg taaatggtgg agacctcatg

1501 tttcagattc agcgctcccg aaaattcgac gagcctcgtt cacggttcta tgctgcagag

1561 gtcacatcgg ccctcatgtt cctccatcag catggagtca tctacaggga tttgaaactg

1621 gacaacatcc ttctggatgc agaaggtcac tgcaagctgg ctgacttcgg gatgtgcaag

1681 gaagggattc tgaatggtgt gacgaccacc acgttctgtg ggactcctga ctacatagct

1741 cctgagatcc tgcaggagtt ggagtatggc ccctccgtgg actggtgggc cctgggggtg

1801 ctgatgtacg agatgatggc tggacagcct ccctttgagg ccgacaatga ggacgaccta

1861 tttgagtcca tcctccatga cgacgtgctg tacccagtct ggctcagcaa ggaggctgtc

1921 agcatcttga aagctttcat gacgaagaat ccccacaagc gcctgggctg tgtggcatcg

1981 cagaatggcg aggacgccat caagcagcac ccattcttca aagagattga ctgggtgctc

2041 ctggagcaga agaagatcaa gccacccttc aaaccacgca ttaaaaccaa aagagacgtc

2101 aataattttg accaagactt tacccgggaa gagccggtac tcacccttgt ggacgaagca

2161 attgtaaagc agatcaacca ggaggaattc aaaggtttct cctactttgg tgaagacctg

2221 atgccctgag agcccactgc agtt

(2) INFORMATION FOR SEQ ID NO: 168: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 218 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 168: agccggcttc tggaaactcc ctgtgtgagt gtgagggaat gagtatgaac aaggcacatt

61 atgtcttact tattgtatta gtttcctgtt gctgctgtag caagttacca ccaatttatg 121 gcttaaagca attcaaattt tttctcttga attcttaaga tcagaagttc taaatgagtc 181 taatggggct aaaatcaagg tgttaggcaa aggcagct

(2) INFORMATION FOR SEQ ID NO: 169: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1830 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 169: tgcagctgga gatccgggct cccacagcag atgagatcca cgtaactgtt ggcgaggccc

61 gtaacctaat tcctatggac cccaatggtc tctctgatcc ctatgtgaaa ctgaagctca 121 tcccagaccc tcggaacctg acgaaacaga agacccgaac ggtgaaagcc acgctaaacc 181 ctgtgtggaa tgagaccttt gtgttcaacc tgaagccagg ggatgtggag cgccggctca

241 gcgtggaggt gtgggactgg gaccggacct cccgcaacga cttcatgggg gccatgtcct

301 ttggcgtctc ggagctgctc aaggcgcccg tggatggctg gtacaagtta ctgaaccagg

361 aggagggcga gtattacaat gtgccggtgg ccgatgctga caactgcagc ctcctccaga

421 agtttgaggc ttgtaactac cccctggaat tgtatgagcg ggtgcggatg ggcccctctt

481 cctctcccat cccctcccct tcccctagtc ccaccgaccc caagcgctgc ttcttcgggg

541 cgagtccagg acgcctgcac atctccgact tcagcttcct catggttcta ggaaaaggca

601 gttttgggaa ggtgatgctg gccgagcgca ggggctctga tgagctctac gccatcaaga

661 tcttgaaaaa ggacgtgatc gtccaggacg acgatgtgga ctgcacgctg gtggagaaac

721 gtgtgctggc gctggggggc cggggtcctg gcggccggcc ccacttcctc acccagctcc

781 actccacctt ccagaccccg gaccgcctgt atttcgtgat ggagtacgtc accgggggag

841 acttgatgta ccacattcaa cagctgggca agtttaagga gccccatgca gcgttctacg

901 cggcagaaat cgctatcggc ctcttcttcc ttcacaatca gggcatcatc tacagggacc

961 tgaagctgga caatgtgatg ctggatgctg agggacacat caagatcact gactttggca

1021 tgtgtaagga gaacgtcttc cccgggacga caacccgcac cttctgcggg accccggact

1081 acatagcccc ggagatcatt gcctaccagc cctatgggaa gtctgtcgat tggtggtcct

1141 ttggagttct gctgtatgag atgttggcag gacagcctcc cttcgatggg gaggacgagg

1201 aggagctgtt tcaggccatc atggaacaaa ctgtcaccta ccccaagtcg ctttcccggg

1261 aagccgtggc catctgcaag gggttcctga ccaagcaccc agggaagcgc ctgggctcag

1321 ggcctgatgg ggaacctacc atccgtgcac atggcttttt ccgctggatt gactgggagc

1381 ggctggaacg attggagatc ccgcctcctt tcagaccccg cccgtgtggc cgcagcggcg

1441 agaactttga caagttcttc acgcgggcgg cgccagcgct gacccctcca gaccgcctag

1501 tcctggccag catcgaccag gccgatttcc agggcttcac ctacgtgaac cccgacttcg

1561 tgcacccgga tgcccgcagc cccaccagcc cagtgcctgt gcccgtcatg taatctcacc

1621 cgccgccact aggtgtcccc aacgtcccct ccgccgtgcc ggcggcagcc ccacttcacc

1681 cccaacttca ccaccccctg tcccattcta gatcctgcac cccagcattc cagctctgcc

1741 cccgcgggtt ctagacgccc ctcccaagcg ttcctggcct tctgaactcc atacagcctc

1801 tacagccgtc ccgcgttcaa gacttgagcg

(2) INFORMATION FOR SEQ ID NO: 170: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2196 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 170: cggggtgtct tgggcccggg cggctgtaga ggcggcggcg cctacgggca gtgggaggag

61 ccgcgcggtt ccggctgctc cggcgaggcg acccttgggt cggcgctgcg ggcaggtggc

121 aggtaggtgg cggacggccg cggttctccg gcaagcgcag gcggcggagt cccccacggc

181 gcccgaagcg cccccccgca cccccggcct ccagcgttga ggcgggggag tgaggagatg

241 ccgacccaga gggacagcag caccatgtcc cacacggtcg caggcggcgg cagcggggac

301 cattcccacc aggtccgggt gaaagcctac taccgcgggg atatcatgat aacacatttt

361 gaaccttcca tctcctttga gggcctttgc aatgaggttc gagacatgtg ttcttttgac

421 aacgaacagc tcttcaccat gaaatggata gatgaggaag gagacccgtg tacagtatca

481 tctcagttgg agttagaaga agcctttag^'a ctttatgagc taaacaagga ttctgaactc

541 ttgattcatg tgttcccttg tgtaccagaa cgtcctggga tgccttgtcc aggagaagat

601 aaatccatct accgtagagg tgcacgccgc tggagaaagc tttattgtgc caatggccac

661 actttccaag ccaagcgttt caacaggcgt gctcactgtg ccatctgcac agaccgaata

721 tggggacttg gacgccaagg atataagtgc atcaactgca aactcttggt tcataagaag

781 tgccataaac tcgtcacaat tgaatgtggg cggcattctt tgccacagga accagtgatg

841 cccatggatc agtcatccat gcattctgac catgcacaga cagtaattcc atataatcct

901 tcaagtcatg agagtttgga tcaagttggt gaagaaaaag aggcaatgaa caccagggaa

961 agtggcaaag cttcatccag tctaggtctt caggatttta atttgctccg ggtaatagga

1021 agaggaagtt atgccaaagt actgttggtt cgattaaaaa aaacagatcg tatttatgca

1081 atgaaagttg tgaaaaaaga gcttgttaat gatgatgagg atattgattg ggtacagaca

1141 gagaagcatg tgtttgagca ggcatccaat catcctttcc ttgttgggct gcattcttgc

1201 tttcagacag aaagcagatt gttctttgtt atagagtatg taaatggagg agacctaatg

1261 tttcatatgc agcgacaaag aaaacttcct gaagaacatg ccagatttta ctctgcagaa

1321 atcagtctag cattaaatta tcttcatgag cgagggataa tttatagaga tttgaaactg

1381 gacaatgtat tactggactc tgaaggccac attaaactca ctgactacgg catgtgtaag

1441 gaaggattac ggccaggaga tacaaccagc actttctgtg gtactcctaa ttacattgct

1501^' cctgaaattt taagaggaga agattatggt ttcagtgttg actggtgggc tcttggagtg

1561 ctcatgtttg agatgatggc aggaaggtct ccatttgata ttgttgggag ctccgataac

1621 cctgaccaga acacagagga ttatctcttc caagttattt tggaaaaaca aattcgcata

1681 ccacgttctc tgtctgtaaa agctgcaagt gttctgaaga gttttcttaa taaggaccct

1741 aaggaacgat tgggttgtca tcctcaaaca ggatttgctg atattcaggg acacccgttc

1801 ttccgaaatg ttgattggga tatgatggag caaaaacagg tggtacctcc ctttaaacca

1861 aatatttctg gggaatttgg tttggacaac tttgattctc agtttactaa tgaacctgtc

1921 cagctcactc cagatgacga tgacattgtg aggaagattg atcagtctga atttgaaggt

1981 tttgagtata tcaatcctct tttgatgtct gcagaagaat gtgtctgatc ctcatttttc

2041 aaccatgtat tctactcatg ttgccattta atgcatggat aaacttgctg caagcctgga

2101 tacaattaac cattttatat ttgccaccta caaaaaaaca cccaatatct tctcttgtag 2161 actatatgaa tcaattatta catctcgacc cggaat

(2) INFORMATION FOR SEQ ID NO: 171: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2389 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 171: gaattcggac ggaggaggca gaatggccag tcgaggggcg cttaggcgtg gcctttcccc

61 agggctgcct cgactcctgc acctgtcccg agggctggcc tgagacggga ctcccggttc

121 tcccgctgcg aagcaggccc cccggggccg gggcagcggc gccggcatgt cgtctggcac

181 catgaagttc aatggctatt tgagggtccg catcggtgag gcagtggggc tgcagcccac

241 ccgctggtcc ctgcgccact cgctcttcaa gaagggccac cagctgctgg acccctatct

301 gacggtgagc gtggaccagg tgcgcgtggg ccagaccagc accaagcaga agaccaacaa

361 acccacgtac aacgaggagt tttgcgctaa cgtcaccgac ggcggccacc tcgagttggc

421 cgtcttccac gagacccccc tgggctacga cttcgtggcc aactgcaccc tgcagttcca

481 ggagctcgtc ggcacgaccg gcgcctcgga caccttcgag ggttgggtgg atctcgagcc

541 agaggggaaa gtatttgtgg taataaccct taccgggagt ttcactgaag ctactctcca

601 gagagaccgg atcttcaaac attttaccag gaagcgccaa agggctatgc gaaggcgagt

661 ccaccagatc aatggacaca agttcatggc cacgtatctg aggcagccca cctactgctc

721 tcactgcagg gagtttatct ggggagtgtt tgggaaacag ggttatcagt gccaagtgtg

781 cacctgtgtc gtccataaac gctgccatca tctaattgtt acagcctgta cttgccaaaa

841 caatattaac aaagtggatt caaagattgc agaacagagg ttcgggatca acatcccaca

901 caagttcagc atccacaact acaaagtgcc aacattctgc gatcactgtg gctcactgct

961 ctggggaata atgcgacaag gacttcagtg taaaatatgt aaaatgaatg tgcatattcg

1021 atgtcaagcg aacgtggccc ctaactgtgg ggtaaatgcg gtggaacttg ccaagaccct

1081 ggcagggatg ggtctccaac ccggaaatat ttctccaacc tcgaaactcg tttccagatc

1141 gaccctaaga cgacagggaa aggagagcag caaagaagga aatgggattg gggttaattc

1201 ttccaaccga cttggtatcg acaactttga gttcatccga gtgttgggga aggggagttt

1261 tgggaaggtg atgcttgcaa gagtaaaaga aacaggagac ctctatgctg tgaaggtgct

1321 gaagaaggac gtgattctgc tggatgatga tgtggaatgc accatgaccg agaaaaggat

1381 cctgtctctg gcccgcaatc accccttcct cactcagttg ttctgctgct ttcagacccc

1441 cgatcgtctg ttttttgtga tggagtttgt gaatgggggt gacttgatgt tccacattca

1501 gaagtctcgt cgttttgatg aagcacgagc tcgcttctat gctgcagaaa tcatttcggc

1561 tctcatgttc ctccatgata aaggaatcat ctatagagat ctgaaactgg acaatgtcct

1621 gttggaccac gagggtcact gtaaactggc agacttcgga atgtgcaagg aggggatttg

1681 caatggtgtc accacggcca cattctgtgg cacgccagac tatatcgctc cagagatcct

1741 ccaggaaatg ctgtacgggc ctgcagtaga ctggtgggca atgggcgtgt tgctctatga

1801 gatgctctgt ggtcacgcgc cttttgaggc agagaatgaa gatgacctct ttgaggccat

1861 actgaatgat gaggtggtct accctacctg gctccatgaa gatgccacag ggatcctaaa

1921 atctttcatg accaagaacc ccaccatgcg cttgggcagc ctgactcagg gaggcgagca

1981 cgccatcttg agacatcctt tttttaagga aatcgactgg gcccagctga accatcgcca

2041 aatagaaccg cctttcagac ccagaatcaa atcccgagaa gatgtcagta attttgaccc

2101 tgacttcata aaggaagagc cagttttaac tccaattgat gagggacatc ttccaatgat

2161 taaccaggat gagtttagaa acttttccta tgtgtctcca gaattgcaac catagcctta

2221 tggggagtga gagagagggc acgagaaccc aaaggaatag agattctcca ggaatttcct

2281 ctatcggacc ttcccagcat cagccttaga acaagaacct taccttcaag gagcaagtga

2341 agaactctgt cgaaggatgg aactttcaga tatcaactat ttagagtcc

(2) INFORMATION FOR SEQ ID NO: 172: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3742 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 172: gaattccttc tctcctcctc ctcgcccttc tcctcgccct cctcctcctc ctcgccctcc

61 cctcccgatc ctcatcccct tgccctcccc cagcccaggg acttttccgg aaagttttta

121 ttttccgtct gggctctcgg agaaagaagc tcctggctca gcggctgcaa aactttcctg

181 ctgccgcgcc gccagccccc gccctccgct gcccggccct gcgccccgcc gagcgatgag

241 cgcccctccg gtcctgcggc cgcccagtcc gctgctgccc gtggcggcgg cagctgccgc

301 agcggccgcc gcactggtcc cagggtccgg gcccgggccc gcgccgttct tggctcctgt

361 cgcggccccg gtcgggggca tctcgttcca tctgcagatc ggcctgagcc gtgagccggt

421 gctgctgctg caggactcgt ccggggacta cagcctggcg cacgtccgcg agatggcttg

481 ctccattgtc gaccagaagt tccctgaatg tggtttctac ggaatgtatg ataagatcct

541 gctttttcgc catgacccta cctctgaaaa catccttcag ctggtgaaag cggccagtga

601 tatccaggaa ggcgatctta ttgaagtggt cttgtcacgt tccgccacct ttgaagactt

661 tcagattcgt ccccacgctc tctttgttca ttcatacaga gctccagctt tctgtgatca

721 ctgtggagaa atgctgtggg ggctggtacg tcaaggtctt aaatgtgaag ggtgtggtct

781 gaattaccat aagagatgtg catttaaaat acccaacaat tgcagcggtg tgaggcggag

841 aaggctctca aacgtttccc tcactggggt cagcaccatc cgcacatcat ctgctgaact

901 ctctacaagt gcccctgatg agccccttct gcaaaaatca ccatcagagt cgtttattgg

961 tcgagagaag aggtcaaatt ctcaatcata cattggacga ccaattcacc ttgacaagat

1021 tttgatgtct aaagttaaag tgccgcacac atttgtcatc cactcctaca cccggcccac 1081 agtgtgccag tactgcaaga agcttctgaa ggggcttttc aggcagggct tgcagtgcaa 1141 agattgcaga ttcaactgcc ataaacgttg tgcaccgaaa gtaccaaaca actgccttgg 1201 cgaagtgacc attaatggag atttgcttag ccctggggca gagtctgatg tggtcatgga 1261 agaagggagt gatgacaatg atagtgaaag gaacagtggg ctcatggatg atatggaaga 1321 agcaatggtc caagatgcag agatggcaat ggcagagtgc cagaacgaca gtggcgagat 1381 gcaagatcca gacccagacc acgaggacgc caacagaacc atcagtccat caacaagcaa 1441 caatatccca ctcatgaggg tagtgcagtc tgtcaaacac acgaagagga aaagcagcac 1501 agtcatgaaa gaaggatgga tggtccacta caccagcaag gacacgctgc ggaaacggca 1561 ctattggaga ttggatagca aatgtattac cctctttcag aatgacacag gaagcaggta 1621 ctacaaggaa attcctttat ctgaaatttt gtctctggaa ccagtaaaaa cttcagcttt 1681 aattcctaat ggggccaatc ctcattgttt cgaaatcact acggcaaatg tagtgtatta 1741 tgtgggagaa aatgtggtca atccttccag cccatcacca aataacagtg ttctcaccag 1801 tggcgttggt gcagatgtgg ccaggatgtg ggagatagcc atccagcatg cccttatgcc 1861 cgtcattccc aagggctcct ccgtgggtac aggaaccaac ttgcacagag atatctctgt 1921 gagtatttca gtatcaaatt gccagattca agaaaatgtg gacatcagca cagtatatca 1981 gatttttcct gatgaagtac tgggttctgg acagtttgga attgtttatg gaggaaaaca 2041 tcgtaaaaca ggaagagatg tagctattaa aatcattgac aaattacgat ttccaacaaa 2101 acaagaaagc cagcttcgta atgaggttgc aattctacag aaccttcatc accctggtgt 2161 tgtaaatttg gagtgtatgt ttgagacgcc tgaaagagtg tttgttgtta tggaaaaact 2221 ccatggagac atgctggaaa tgatcttgtc aagtgaaaag ggcaggttgc cagagcacat 2281 aacgaagttt ttaattactc agatactcgt ggctttgcgg caccttcatt ttaaaaatat 2341 cgttcactgt gacctcaaac cagaaaatgt gttgctagcc tcagctgatc cttttcctca 2401 ggtgaaactt tgtgattttg gttttgcccg gatcattgga gagaagtctt tccggaggtc 2461 agtggtgggt acccccgctt acctggctcc tgaggtccta aggaacaagg gctacaatcg 2521 ctctctagac atgtggtctg ttggggtcat catctatgta agcctaagcg gcacattccc 2581 atttaatgaa gatgaagaca tacacgacca aattcagaat gcagctttca tgtatccacc 2641 aaatccctgg aaggaaatat ctcatgaagc cattgatctt atcaacaatt tgctgcaagt 2701 aaaaatgaga aagcgctaca gtgtggataa gaccttgagc cacccttggc tacaggacta 2761 tcagacctgg ttagatttgc gagagctgga atgcaaaatc ggggagcgct acatcaccca 2821 tgaaagtgat gacctgaggt gggagaagta tgcaggcgag cagcggctgc agtaccccac 2881 acacctgatc aatccaagtg ctagccacag tgacactcct gagactgaag aaacagaaat 2941 gaaagccctc ggtgagcgtg tcagcatcct ctgagttcca tctcctataa tctgtcaaaa 3001 cactgtggaa ctaataaata catacggtca ggtttaacat ttgccttgca gaactgccat 3061 tattttctgt cagatgagaa caaagctgtt aaactgttag cactgttgat gtatctgagt 3121 tgccaagaca aatcaacaga agcatttgta ttttgtgtga ccaactgtgt tgtattaaca 3181 aaagttccct gaaacacgaa acttgttatt gtgaatgatt catgttatat ttaatgcatt 3241 aaacctgtct ccactgtgcc tttgcaaatc agtgtttttc ttactggagc ttcattttgg 3301 taagagacag aatgtatctg tgaagtagtt ctgtttggtg tgtcccattg gtgttgtcat 3361 tgtaaacaaa ctcttgaaga gtcgattatt tccagtgttc tatgaacaac tccaaaaccc 3421 atgtgggaaa aaaatgaatg aggagggtag ggaataaaat cctaagacac aaatgcatga 3481 acaagtttta atgtatagtt ttgaatcctt tgcctgcctg gtgtgcctca gtatatttaa 3541 actcaagaca atgcacctag ctgtgcaaga cctagtgctc ttaagcctaa atgccttaga 3601 aatgtaaact gccatatata acagatacat ttccctcttt cttataatac tctgttgtac 3661 tatggaaaat cagctgctca gcaacctttc acctttgtgt atttttcaat aataaaaaat 3721 attcttgtca aaaaaaaaaa aa

(2) INFORMATION FOR SEQ ID NO: 173: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2705 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:173: tgctcgctcc agggcgcaac catgtcgcca tttcttcgga ttggcttgtc caactttgac

61 tgcgggtcct gccagtcttg tcagggcgag gctgttaacc cttactgtgc tgtgctcgtc

121 aaagagtatg tcgaatcaga gaacgggcag atgtatatcc agaaaaagcc taccatgtac

181 ccaccctggg acagcacttt tgatgcccat atcaacaagg gaagagtcat gcagatcatt

241 gtgaaaggca aaaacgtgga cctcatctct gaaaccaccg tggagctcta ctcgctggct

301 gagaggtgca ggaagaacaa cgggaagaca gaaatatggt tagagctgaa acctcaaggc

361 cgaatgctaa tgaatgcaag atactttctg gaaatgagtg acacaaagga catgaatgaa

421 tttgagacgg aaggcttctt tgctttgcat cagcgccggg gtgccatcaa gcaggcaaag

481 gtccaccacg tcaagtgcca cgagttcact gccaccttct tcccacagcc cacattttgc

541 tctgtctgcc acgagtttgt ctggggcctg aacaaacagg gctaccagtg ccgacaatgc

601 aatgcagcaa ttcacaagaa gtgtattgat aaagttatag caaagtgcac aggatcagct

661 atcaatagcc gagaaaccat gttccacaag gagagattca aaattgacat gccacacaga

721 tttaaagtct acaattacaa gagcccgacc ttctgtgaac actgtgggac cctgctgtgg

781 ggactggcac ggcaaggact caagtgtgat gcatgtggca tgaatgtgca tcatagatgc

841 cagacaaagg tggccaacct ttgtggcata aaccagaagc taatggctga agcgctggcc

901 atgattgaga gcactcaaca ggctcgctgc ttaagagata ctgaacagat cttcagagaa

961 ggtccggttg aaattggtct cccatgctcc atcaaaaatg aagcaaggcc gccatgttta

1021 ccgacaccgg gaaaaagaga gcctcagggc atttcctggg agtctccgtt ggatgaggtg

1081 gataaaatgt gccatcttcc agaacctgaa ctgaacaaag aaagaccatc tctgcagatt

1141 aaactaaaaa ttgaggattt tatcttgcac aaaatgttgg ggaaaggaag ttttggcaag

1201 gtcttcctgg cagaattcaa gaaaaccaat caatttttcg caataaaggc cttaaagaaa

1261 gatgtggtct tgatggacga tgatgttgag tgcacgatgg tagagaagag agttctttcc 1321 ttggcctggg agcatccgtt tctgacgcac atgttttgta cattccagac caaggaaaac

1381 ctcttttttg tgatggagta cctcaacgga ggggacttaa tgtaccacat ccaaagctgc

1441 cacaagttcg acctttccag agcgacgttt tatgctgctg aaatcattct tggtctgcag

1501 ttccttcatt ccaaaggaat agtctacagg gacctgaagc tagataacat cctgttagac

1561 aaagatggac atatcaagat cgcggatttt ggaatgtgca aggagaacat gttaggagat

1621 gccaagacga ataccttctg tgggacacct gactacatcg ccccagagat cttgctgggt

1681 cagaaataca accactctgt ggactggtgg tccttcgggg ttctccttta tgaaatgctg

1741 attggtcagt cgcctttcca cgggcaggat gaggaggagc tcttccactc catccgcatg

1801 gacaatccct tttacccacg gtggctggag aaggaagcaa aggaccttct ggtgaagctc

1861 ttcgtgcgag aacctgagaa gaggctgggc gtgaggggag acatccgcca gcaccctttg

1921 tttcgggaga tcaactggga ggaacttgaa cggaaggaga ttgacccacc gttccggccg

1981 aaagtgaaat caccatttga ctgcagcaat ttcgacaaag aattcttaaa cgagaagccc

2041 cggctgtcat ttgccgacag agcactgatc aacagcatgg accagaatat gttcaggaac

2101 ttttccttca tgaaccccgg gatggagcgg ctgatatcct gaatcttgcc cctccagaga

2161 caggaaagaa tttgccttct ccctgggaac tggttcaaga gacactgctt gggttccttt

2221 ttcaacttgg aaaaagaaag aaacactcaa caataaagac tgagacccgt tcgcccccat

2281 gtgactttat ctgtagcaga aaccaagtct acttcactaa tgacgatgcc gtgtgtctcg

2341 tctcctgaca tgtctcacag acgctcctga agttaggtca ttactaacca tagttattta

2401 cttgaaagat gggtctccgc acttggaaag gtttcaagac ttgatactgc aataaattat

2461 ggctcttcac ctgggcgcca actgctgatc aacgaaatgc ttgttgaatc aggggcaaac

2521 ggagtacaga cgtctcaaga ctgaaacggc cccattgcct ggtctagtag cggatctcac

2581 tcagccgcag acaagtaatc actaacccgt tttattctat cctatctgtg gatgtataaa

2641 tgctgggggc cagccctgga taggttttta tgggaattct ttacaataaa catagcttgt

2701 acttg

(2) INFORMATION FOR SEQ ID NO: 174: (l) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 1779 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 174: atgcccagca ggaccgaccc caagatggaa gggagcggcg gccgcgtceg cctcaaggcg

61 cattacgggg gggacatctt catcaccagc gtggacgccg ccacgacctt cgaggagctc

121 tgtgaggaag tgagagacat gtgtcgtctg caccagcagc acccgctcac cctcaagtgg

181 gtggacagcg aaggtgaccc ttgcacggtg tcctcccaga tggagctgga agaggctttc

241 cgcctggccc gtcagtgcag ggatgaaggc ctcatcattc atgttttccc gagcacccct

301 gagcagcctg gcctgccatg tccgggagaa gacaaatcta tctaccgccg gggagccaga

361 agatggagga agctgtaccg tgccaacggc cacctcttcc aagccaagcg ctttaacagg

421 agagcgtact gcggtcagtg cagcgagagg atatggggcc tcgcgaggca aggctacagg

481 tgcatcaact gcaaactgct ggtccataag cgctgccacg gcctcgtccc gctgacctgc

541 aggaagcata tggattctgt catgccttcc caagagcctc cagtagacga caagaacgag

601 gacgccgacc ttccttccga ggagacagat ggaattgctt acatttcctc atcccggaag

661 catgacagca ttaaagacga ctcggaggac cttaagccag ttatcgatgg gatggatgga

721 atcaaaatct ctcaggggct tgggctgcag gactttgacc taatcagagt catcgggcgc

781 gggacgtacg ccaaggttct cctggtgcgg ttgaagaaga atgaccaaat ttacgccatg

841 aaagtggtga agaaagagct ggtgcatgat gacgaggata ttgactgggt acagacagag

901 aagcacgtgt ttgagcaggc atccagcaac cccttcctgg tcggattaca ctcctgcttc

961 cagacgacaa gtcggttgtt cctggtcatt gagtacgtca acggcgggga cctgatgttc

1021 cacatgcaga ggcagaggaa gctccctgag gagcacgcca ggttctacgc ggccgagatc

1081 tgcatcgccc tcaacttcct gcacgagagg gggatcatct acagggacct gaagctggac

1141 aacgtcctcc tggatgcgga cggacacatc aagctcacag actacggcat gtgcaaggaa

1201 ggcctgggcc ctggtgacac aacgagcact ttctgcggaa ccccgaatta catcgccccc

1261 gaaatcctgc ggggagagga gtacgggttc agcgtggact ggtgggcgct gggagtcctc

1321 atgtttgaga tgatggccgg gcgctccccg ttcgacatca tcaccgacaa cccggacatg

1381 aacacagagg actacctttt ccaagtgatc ctggagaagc ccatccggat cccccggttc

1441 ctgtccgtca aagcctccca tgttttaaaa ggatttttaa ataaggaccc caaagagagg

1501 ctcggctgcc ggccacagac tggattttct gacatcaagt cccacgcgtt cttccgcagc

1561 atagactggg acttgctgga gaagaagcag gcgctccctc cattccagcc acagatcaca

1621 gacgactacg gtctggacaa ctttgacaca cagttcacca gcgagcccgt gcagctgacc

1681 ccagacgatg aggatgccat aaagaggatc gaccagtcag agttcgaagg ctttgagtat

1741 atcaacccat tattgctgtc caccgaggag tcggtgtga

(2) INFORMATION FOR SEQ ID NO: 175: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 239 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 175:

1 tqtcatgcct tcccaagagc ctccaggatg gctgtcctcc gacctcctcc acctccaggc

61 tctagatggc aaagcccact tagcaaaagc cacctgctct gtgatgatgg gactggctcc

121 tgcctgtggg ttcggaaagc ccatcccacc ctctacagcc tcttgctcct ctgcaatgac 181 tgtgccttca cctgggggtt ccccagagac tagtgagagt catcgggcgt ggaagctat

(2) INFORMATION FOR SEQ ID NO: 176: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 38634 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 176: ggagcaagag gtggttgggg ggggaccatg gctgacgttt tcccgggcaa cgactccacg

61 gcgtctcagg acgtggccaa ccgcttcgcc cgcaaagggg cgctgaggca gaagaacgtg

121 cacgaggtga aggaccacaa attcatcgcg cgcttcttca agcagcccac cttctgcagc

181 cactgcaccg acttcatctg ggggtttggg aaacaaggct tccagtgcca agtttgctgt

241 tttgtggtcc acaagaggtg ccatgaattt gttacttttt cttgtccggg tgcggataag

301 ggacccgaca ctgatgaccc caggagcaag cacaagttca aaatccacac ttacggaagc

361 cccaccttct gcgatcactg tgggtcactg ctctatggac ttatccatca agggatgaaa

421 tgtgacacct gcgatatgaa cgttcacaag caatgcgtca tcaatgtccc cagcctctgc

481 ggaatggatc acactgagaa gagggggcgg atttacctaa aggctgaggt tgctgatgaa

541 aagctccatg tcacagtacg agatgcaaaa aatctaatcc ctatggatcc aaacgggctt

601 tcagatcctt atgtgaagct gaaacttatt cctgatccca agaatgaaag caagcaaaaa

661 accaaaacca tccgctccac actaaatccg cagtggaatg agtcctttac attcaaattg

721 aaaccttcag acaaagaccg acgactgtct gtagaaatct gggactggga tcgaacaaca

781 aggaatgact tcatgggatc cctttccttt ggagtttcgg agctgatgaa gatgccggcc

841 agtggatggt acaagttgct taaccaagaa gaaggtgagt actacaacgt acccattccg

901 gaaggggacg aggaaggaaa catggaactc aggcagaaat tcgagaaagc caaacttggc

961 cctgctggca acaaagtcat cagtccctct gaagacagga aacaaccttc caacaacctt

1021 gaccgagtga aactcacgga cttcaatttc ctcatggtgt tgggaaaggg gagttttgga

1081 aaggtgatgc ttgccgacag gaagggcaca gaagaactgt atgcaatcaa aatcctgaag

1141 aaggatgtgg tgattcagga tgatgacgtg gagtgcacca tggtagaaaa gcgagtcttg

1201 gccctgcttg acaaaccccc gttcttgacg cagctgcact cctgcttcca gacagtggat

1261 cggctgtact tcgtcatgga atatgtcaac ggtggggacc tcatgtacca cattcagcaa

1321 gtaggaaaat ttaaggaacc acaagcagta ttctatgcgg cagagatttc catcggattg

1381 ttctttcttc ataaaagagg aatcatttat agggatctga agttagataa cgtcatgttg

1441 gattcagaag gacatatcaa aattgctgac tttgggatgt gcaaggaaca catgatggat

1501 ggagtcacga ccaggacctt ctgtgggact ccagattata tcgccccaga gataatcgct

1561 tatcagccgt atggaaaatc tgtggactgg tgggcctatg gcgtcctgtt gtatgaaatg

1621 cttgccgggc agcctccatt tgatggtgaa gatgaagacg agctatttca gtctatcatg

1681 gagcacaacg tttcctatcc aaaatccttg tccaaggagg ctgtttctat ctgcaaagga

1741 ctgatgacca aacacccagc caagcggctg ggctgtgggc ctgaggggga gagggacgtg

1801 agagagcatg ccttcttccg gaggatcgac tgggaaaaac tggagaacag ggagatccag

1861 ccaccattca agcccaaagt gtgtggcaaa ggagcagaga actttgacaa gttcttcaca

1921 cgaggacagc ccgtcttaac accacctgat cagctggtta ttgctaacat agaccagtct

1981 gattttgaag ggttctcgta tgtcaacccc cagtttgtgc accccatctt acagagtgca

2041 gtatgaaact caccagcgag aacaaacacc tccccagccc ccagccctcc ccgcagtgga

2101 agtgaatcct taaccctaaa attttaaggc cacggcttgt gtctgattcc atatggaggc

2161 ctgaaaattg tagggttatt agtccaaatg tgatcaactg ttcagggtct ctctcttaca

2221 accaagaaca ttatcttagt ggaag cttatcacag ttcaagtgat ttccagaagt tccagggctt ctgagagacc atcaagggaa

61 ctttaacaac ttgacaaatg tccttgaagt aagatgcctc atctttaggg aaaaatgggg 121 tttggatttc tgcttaggca aagtctcctg cagttcatcc ttctctgtcc tcttcttgct 181 tcaggcttgg ggaccgtccc tgctgtcccc actgtggtgg caatcaggac ctaaggtgaa 241 gcaaacttga agttctatct gacaagttta ggcagtaaga gaaggaggga aatcggagca 301 aagctccctc actttattgt tgagaaactg gcatctggaa agaagaagga atttgcccaa 361 agtcagtcag ctgggataaa aacctgggtg tcctgtccag aaagtgcagg gtgctttctg 421 ctctgtagca aggcagcaga catctctgag ccaggcccac caacaggccc ttatctggtg 481 gttggatcat gatcccattt tgcttggaca tgctctcagg aagataaaaa ccatggagaa 541 acactaggcc attgacaaat gatctgagac aactttagaa aacaatgtag gatgaatgga 601 aagagaaaga aaggaaagaa aaaaaaaaaa aaaagg cagagccggc gcaggggaag cgcccggggc cccgggtgca gcagcgcccg ccgcctcccg

61 ggcctccccg gcccgcagcc cggggtcccg ggccccgggg ccggcacctc tcgggctccg 121 gctccccgcg cgcaagatgg ctgacccggc tgcggggccg ccgccgagcg agggcgagga 181 gagcaccgtg cgcttcgccc gcaaaggcgc cctccggcag aagaacgtgc atgaggtcaa 241 gaaccacaaa ttcaccgccc gcttcttcaa gcagcccacc ttctgcagcc actgcaccga 301 cttcatctgg ggcttcggga agcagggatt ccagtgccaa gtttgctgct ttgtggtgca 361 caagcggtgc catgaatttg tcacattctc ctgccctggc gctgacaagg gtccagcctc 421 cgatgacccc cgcagcaaac acaagtttaa gatccacacg tactccagcc ccacgttttg 481 tgaccactgt gggtcactgc tgtatggact catccaccag gggatgaaat gtgacacctg 541 catgatgaat gtgcacaagc gctgcgtgat gaatgttccc agcctgtgtg gcacggacca 601 cacggagcgc cgcggccgca tctacatcca ggcccacatc gacagggacg tcctcattgt 661 cctcgtaaga gatgctaaaa accttgtacc tatggacccc aatggcctgt cagatcccta

721 cgtaaaactg aaactgattc ccgatcccaa aagtgagagc aaacagaaga ccaaaaccat

781 caaatgctcc ctcaaccctg agtggaatga gacatttaga tttcagctga aagaatcgga

841 caaagacaga agactgtcag tagagatttg ggattgggat ttgaccagca ggaatgactt

901 catgggatct ttgtcctttg ggatttctga acttcagaag gccagtgttg atggctggtt

961 taagttactg agccaggagg aaggcgagta cttcaatgtg cctgtgccac cagaaggaag

1021 tgaggccaat gaagaactgc ggcagaaatt tgagagggcc aagatcagtc agggaaccaa

1081 ggtcccggaa gaaaagacga ccaacactgt ctccaaattt gacaacaatg gcaacagaga

1141 ccggatgaaa ctgaccgatt ttaacttcct aatggtgctg gggaaaggca gctttggcaa

1201 ggtcatgctt tcagaacgaa aaggcacaga tgagctctat gctgtgaaga tcctgaagaa

1261 ggacgttgtg atccaagatg atgacgtgga gtgcactatg gtggagaagc gggtgttggc

1321 cctgcctggg aagccgccct tcctgaccca gctccactcc tgcttccaga ccatggaccg

1381 cctgtacttt gtgatggagt acgtgaatgg gggcgacctc atgtatcaca tccagcaagt

1441 cggccggttc aaggagcccc atgctgtatt ttacgctgca gaaattgcca tcggtctgtt

1501 cttcttacag agtaagggca tcatttaccg tgacctaaaa cttgacaacg tgatgctcga

1561 ttctgaggga cacatcaaga ttgccgattt tggcatgtgt aaggaaaaca tctgggatgg

1621 ggtgacaacc aagacattct gtggcactcc agactacatc gcccccgaga taattgctta

1681 tcagccctat gggaagtccg tggattggtg ggcatttgga gtcctgctgt atgaaatgtt

1741 ggctgggcag gcaccctttg aaggggagga tgaagatgaa ctcttccaat ccatcatgga

1801 acacaacgta gcctatccca agtctatgtc caaggaagct gtggccatct gcaaagggct

1861 gatgaccaaa cacccaggca aacgtctggg ttgtggacct gaaggcgaac gtgatatcaa

1921 agagcatgca tttttccggt atattgattg ggagaaactt gaacgcaaag agatccagcc

1981 cccttataag ccaaaagcta gagacaagag agacacctcc aacttcgaca aagagttcac

2041 cagacagcct gtggaactga cccccactga taaactcttc atcatgaact tggaccaaaa

2101 tgaatttgct ggcttctctt atactaaccc agagtttgtc attaatgtgt aggtgaatgc

2161 aaactccatc gttgagcctg gggtgtaaga cttcaagcca agcgtatgta tcaattctag

2221 tcttccagga ttcacggtgc acatgctggc attcaacatg tggaaagctt gtcttagagg

2281 cctttcttgt atgtgtagct tgctagtttg ttttctacat ttgaaaatgt ttagtttaga

2341 ataagcgcat tatccaatta tagaggtaca attttccaaa cttccagaaa ctcatcaaat

2401 gaacagacaa tgtcaaaact actgtgtctg ataccaaaat gcttcagtat ttgtaatttt

2461 tcaagtcaga agctgatgtt cctggtaaaa gtttttacag ttattctata atatcttctt

2521 tgaatgctaa gcatgagcga tatttttaaa aattgtgagt aagcttcgga attc cagagccggc gcaggggaag cgcccggggc cccgggtgca gcagcgcccg ccgcctcccg

61 ggcctccccg gcccgcagcc cggggtcccg ggccccgggg ccggcacctc tcgggctccg

121 gctccccgcg cgcaagatgg ctgacccggc tgcggggccg ccgccgagcg agggcgagga

181 gagcaccgtg cgcttcgccc gcaaaggcgc cctccggcag aagaacgtgc atgaggtcaa

241 gaaccacaaa ttcaccgccc gcttcttcaa gcagcccacc ttctgcagcc actgcaccga

301 cttcatctgg ggcttcggga agcagggatt ccagtgccaa gtttgctgct ttgtggtgca

361 caagcggtgc catgaatttg tcacattctc ctgccctggc gctgacaagg gtccagcctc

421 cgatgacccc cgcagcaaac acaagtttaa gatccacacg tactccagcc ccacgttttg

481 tgaccactgt gggtcactgc tgtatggact catccaccag gggatgaaat gtgacacctg

541 catgatgaat gtgcacaagc gctgcgtgat gaatgttccc agcctgtgtg gcacggacca

601 cacggagcgc cgcggccgca tctacatcca ggcccacatc gacagggacg tcctcattgt

661 cctcgtaaga gatgctaaaa accttgtacc tatggacccc aatggcctgt cagatcccta

721 cgtaaaactg aaactgattc ccgatcccaa aagtgagagc aaacagaaga ccaaaaccat

781 caaatgctcc ctcaaccctg agtggaatga gacatttaga tttcagctga aagaatcgga

841 caaagacaga agactgtcag tagagatttg ggattgggat ttgaccagca ggaatgactt

901 catgggatct ttgtcctttg ggatttctga acttcagaag gccagtgttg atggctggtt

961 taagttactg agccaggagg aaggcgagta cttcaatgtg cctgtgccac cagaaggaag

1021 tgaggccaat gaagaactgc ggcagaaatt tgagagggcc aagatcagtc agggaaccaa

1081 ggtcccggaa gaaaagacga ccaacactgt ctccaaattt gacaacaatg gcaacagaga

1141 ccggatgaaa ctgaccgatt ttaacttcct aatggtgctg gggaaaggca gctttggcaa

1201 ggtcatgctt tcagaacgaa aaggcacaga tgagctctat gctgtgaaga tcctgaagaa

1261 ggacgttgtg atccaagatg atgacgtgga gtgcactatg gtggagaagc gggtgttggc

1321 cctgcctggg aagccgccct tcctgaccca gctccactcc tgcttccaga ccatggaccg

1381 cctgtacttt gtgatggagt acgtgaatgg gggcgacctc atgtatcaca tccagcaagt

1441 cggccggttc aaggagcccc atgctgtatt ttacgctgca gaaattgcca tcggtctgtt

1501 cttcttacag agtaagggca tcatttaccg tgacctaaaa cttgacaacg tgatgctcga

1561 ttctgaggga cacatcaaga ttgccgattt tggcatgtgt aaggaaaaca tctgggatgg

1621 ggtgacaacc aagacattct gtggcactcc agactacatc gcccccgaga taattgctta

1681 tcagccctat gggaagtccg tggattggtg ggcatttgga gtcctgctgt atgaaatgtt

1741 ggctgggcag gcaccctttg aaggggagga tgaagatgaa ctcttccaat ccatcatgga

1801 acacaacgta gcctatccca agtctatgtc caaggaagct gtggccatct gcaaagggct

1861 gatgaccaaa cacccaggca aacgtctggg ttgtggacct gaaggcgaac gtgatatcaa

1921 agagcatgca tttttccggt atattgattg ggagaaactt gaacgcaaag agatccagcc

1981 cccttataag ccaaaagctt gtgggcgaaa tgctgaaaac ttcgaccgat ttttcacccg

2041 ccatccacca gtcctaacac ctcccgacca ggaagtcatc aggaatattg accaatcaga

2101 attcgaagga ttttcctttg ttaactctga atttttaaaa cccgaagtca agagctaagt 2161 agatgtgtag atctccgtcc ttcatttctg tcattcaagc tcaacggcta ttgtggtgac 2221 atttttatgt ttttcattgc caagttgcat ccatgtttga ttttctgatg agactagagt 2281 gacagtgttt cagaacccaa atgtcctcag gtagtttgga gcatctctat gagatgggat 2341 tatgcagatg gcctatggaa aatgcagctg cataattaac acattatcaa agtcctctta 2401 caatttattt tccgcagcat gtcagctaag tagacccaat ggggagagaa aatgcctgct 2461 ttctttccct ctttttctgc actgccatat tcacccccaa ccatccaatc tgtggataat 2521 tggatgttag cggtactctt ccacttccgg tcctggagct tggcttgtat ccaagtgtat 2581 ggttgctttg cctaagagga atccctctat ttcacctgtt ctggaggcac cagaccttga 2641 aaagaacatg ctcaaaataa aatgttatct gttatttttg taaactcaaa gttaagatga 2701 tcaaagttct aaaattccaa gaatgtgctt ttagacggtc tcaatctaaa agcacttcaa 2761 ggggtcaaag ggcaaccagc ttggtgctac ctcagtgttg tagtttctga tactttatgt 2821 ctttgctcac cctcatcccc aaactacttg aaaagggcat ttggcaccac tctctgaaac 2881 aacacagtca ctctagcaag gcccccaaag ggccctggtt ttacattaca tttcaaactt 2941 tatttgcttt ggggttttgt ttctgttgtt gttcaaatgc aaaaaaaaga aaaaaaaaag 3001 aaaaaaaaag gtgactcaca ttgttacaca tgctttaaaa tatgtgttca aatgttatta 3061 accacaatga cgacctgttt tgatttaacc aagaagacgg ctgcggagcc tagcagactc 3121 aggcctgtgg gaatgggatt tgttacaaat ctaggtttgt tactggcttc agaaagctaa 3181 ttaagtgctc tgaaaaagac accgtttctt gaaacaaaga tggttgtatt cctcactttg 3241 atgttgtttt gcaagatgtt tgtggaaatg ttcatttgta tctggatctc tgttatgtgc 3301 catttttctt ctagcatcga g gtccttcatt ccttccacaa ctatttatcc agcaccgttt ctgggcacag ggctccagcg

61 atggtcccaa caggtacaat gacctctggg gaccaagttc agttcttggt gagttctcca 121 gtgcctctcg atgtaggatg aaccgttggc atgctccact gacgctggct ccttctgttg 181 tttctcttgg ctccaggacc cccgcagcaa acacaagttt aagatccaca cgtactccag 241 ccccacgttt tgtgaccact gtgggtcact gctgtatgga ctcatccacc aggggatgaa 301 atgtgacagt aagtactttc tctctctggg ggcatctgct gatggcagaa gcaatgggaa 361 gggctgcttc cacttggttt ggggtccagg tctgccatac attcccccct gtcctcgttg 421 gggctggtgt accagttatc tgttgctgca taatgatcct cccaccccaa aacactgtga 481 ctgaagacaa taaacatttt tttagctcat gactctgcaa ggcagtcctt tgaatctggg 541 ctggcctcag ctgatgtcac gcatgttcat aaagcatgaa ctcatggttc atggtggatt 601 agcagatgga ggtgggctgg g acatcaagga gacgagtcct ggttggatag taatgtcttt aacacccctc tagcatttat

61 taatttcctc tcttaacaaa taaaagatgc ccttcagtca gatgcttagg acagatgacg

121 cacctagaga tattttaata atgtagatac tcttgctgtt caaactcaga ccaaaatgac

181 gataggcttt tttggccccc agagggtgca caaatacgac cagaatttgt gaagacgagt

241 cagaaatgaa tgaaatttgg aaaaatattg atctactgaa atccttcctc cccacactat

301 tagccctatg ttacagttgg ggaaacggag tcgttttgca gaggggatgg acagaaggta

361 gggagttctc ttccaaacgt gcaggaggca agcaaagcca agaatcttct ctgtggtgag

421 ttagagacat ataaaataaa gatcgctcct cccctacctc tgcagaacgt gtgtgtgtat

481 gtgtgtgtaa gtgtgtgcgg ccacaagcct ttccgaatga gtgacagcgg gagcccatcc

541 ctccaggaga cgcgtgcaga atgaccaatg ggatggatgg gggtggatgg gtaccagtct

601 ccgcagaggc cggggtggga attcgctgcg ccccacccct tccacccgct ccccttcgcc

661 ccgtaggtct ttccactctc gctcctcccc tgggcacatc tcctgaacgc agccccgggg

721 gccgaggacg gggtggggtg gggggcgagg ctcgggtccg acgaccccgg gctgcggtcc

781 cggcgctgca gagctgcggc tgtgcacgct tagccgcgag gcccgcggta gcccgggcgc

841 cgatatgtaa agcagctggc agcgctgggc ggggcctggg cgcgactgca aatgaggagg

901 gcgcgggctg gcccgggggc tccgcctccc tcccccgcag ctggggccag cggctgccaa

961 gcgcactggt cgagcggcag cagctgggcg aggtgacagc cccggctccg cgcgccggcc

1021 gccagagccg gcgcagggga agcgcccgcg gccccgggtg cagcagcggc cgccgcctcc

1081 cgcgcctccc cggcccgcag cccgcggtcc cgcgccccgg ggccggcacc tctcgggctc

1141 cggctccccg cgcgcaagat ggctgacccg gctgcggggc cgccgccgag cgagggcgag

1201 gagagcaccg tgcgcttcgc ccgcaaaggc gccctcaggc agaagaacgt gcatgaggtc

1261 aagaaccaca aattcaccgc ccgcttcttc aagcagccca ccttctgcag ccactgcacc

1321 gacttcatct ggtgaccccc caggcactcc ggccccaggc cacgccgcgc caggaccccc

1381 tctccgcgcc ctctgcgccc tccgcaccct ggaccccgcg tccccggact ccccgctccg

1441 gaccctgctg cccgggactc ccggatggac agtcctagcc gttgccctgt ccccaccctg

1501 gtcccagacg ggccgccgcg ggcgcctcct gccctctcct gctctcaggc gcctctaga gtcgactgca ggtcaacgga cacatcaagg agagagtcct ggttggatag taatgtcttt

61 aacacccctc tagcatttat taatttcctc tcttaacaaa taaaagatga cttcagttga 121 agatccttag gacagatgac ggcacctgga gatattttaa taatgtagat accctcttgc 181 tgttcaaact cagaccaaaa gagatggctt tttttccccc agagggtgca caaatacgac 241 agaatttgtg aagacgagtc agaaatgaat gaaatttgga aaaatattga tctactgaaa 301 tccttcctcc ccacactatt agccctatgt tacagttggg gaaacggagt cgttttgcag 361 aggggatgga cagaaggtag ggagttctct tccaacgtgc aggaggcaag caaagccaag 421 catcttctct gtggtggagt tagagacata taaaataaga tcgctcctcc cctacctctg 481 cagaacgtgt gtgtgtatgt gtgtgtaacg tgtgtgcggc cacaagcctt tccgaatgag 541 tgacagcggg agcccatccc tccaggagac gcgtgcagaa tgaccaatgg gatggatggg 601 ggtggatggg taccgtctcc gcgaggccgg ggtggaattc gctgcgcccc accccttcca 661 cccgctcccc ttcgccccgt aggtctttcc actctcgctc ctcccctggg cacatctcct

721 gaacgcagcc ccgggggccg aggacggggt ggggtggggg gcgaggctcg ggtccgacga

781 ccccgggctg cggtcccggc gctgcagagc tgcggctgtg cacgcttagc cgcgaggccc

841 gcggtagccc gggcgccgat atgtaaagca gctggcagcg ctgggcgggg cctgggcgcg

901 atgcaaatga ggagggcggg gctggcccgg ggctccgcct ccctcccccg cagctggggc

961 cagcggtgcc aagcgcagct ggacgagcgg cagcagctgg gcgagtgaca gccccggctc

1021 cgcgcgccgc ggccgccaga gccggcgcag gggaagcgcc cgcggccccg ggtgcagcag

1081 cggccgccgc ctcccgcgcc tccccggccc gcagcccgcg gtcccgcggc cccggggccg

1141 gcacctctcg ggctccggct ccccgcgcgc aagatggctg acccggctgc ggggccgccg

1201 ccgagcgagg gcgaggagag caccgtgcgc ttcgcccgca aaggcgccct caggcagaag

1261 aacgtgcatg aggtcaagaa ccacaaattc accgcccgct tcttcaagca gcccaccttc

1321 tgcagccact gcaccgactt catctggtgg agcgcgcgcg caaggcacct tcccgggccc

1381 ccgaggcagc gccgcgccaa gggaccccct ctccgccctc tgcgccctcc gcaccctgga

1441 ccccgcgtcc ccggactccc cgctccggac cctgctgccg ggactcccgg atggacagtc

1501 ctgccgttgc cctgtcccca ccctggtccc aggacggggg cgcctcctgc cctctcctgc

1561 tctcaggcgc ctctagagcg cccaggggca gcgtcgcggg cgcctttgct ccacctgact

1621 aggagcgcgc ggggtctgtg cctgccctgg agggcagcgc ctcgggtgct ctccgacccg

1681 gggttcccta tctctccgcc tgcttccggg cgcgaggagc cctcgccccc caccccttgt

1741 ttccgggggg ggggggcggc gccctgggtg tccttctcta tctctgcggg catgggacat

1801 cctttctcac tcctctgtgc ctcggcagcg ccctgtgtta tctcccattg ccctccccga

1861 gggcctggtt cccctttcca ctcctcggtc acatcactgc gggccccttt cttccccagt

1921 ccctccagta gtggggcatc ctttcctcct tcccagtccc cctcccagag gacaccaccg

1981 ccgcggggtc actctcgccc tccctctgaa tgcgtcttta tctcttctct tttccgaggg

2041 tgctcggggc atctatgggt acatctgtcg cctgccttca gcccctaccc cgacggaaac

2101 gctccccact atcccgccac ctggtggtcg cagcctcctc tcttctgcag gagtgaaggc

2161 agatcggggt tacagccgag ctcccaccta cccccacaaa ggcggaagac tcttgggcac

2221 ccgcctgtgg ctgggagttt gcacctgggg tacagaggca gggaggaagg cgggtgactc

2281 tgtgggtaac tagctggagg ctgggccccc gggctgcctg acatacacct ccttctgctt

2341 ttgcaggggc ttcgggaagc agggattcca gtgccaaggt aggctctggg gctttgggga

2401 tgctatttgt gggaagagag ggtgaaaaat actttataga agaagttact gagttaggca

2461 gagagtgaaa gaatcacgtt ggtcggagtg acctcccagg ctaggaattc aaagcgacca tgtatcctga gtggaagtcg acgttcgatg cccacatcta tgaggggcgc

61 gtcatccaga ttgtgctaat gcgggcagca gaggagccag tgtctgaggt gaccgtgggt

121 gtgtcggtgc tggccgagcg ctgcaagaag aacaatggca aggctgagtt ctggctggac

181 ctgcagcctc aggccaaggt gttgatgtct gttcagtatt tcctggagga cgtggattgc

241 aaacagtcta tgcgcagtga ggacgaggcc aagttcccaa cgatgaaccg ccgcggagcc

301 atcaaacagg ccaaaatcca ctacatcaag aaccatgagt ttatcgccac cttctttggg

361 caacccacct tctgttctgt gtgcaaagac tttgtctggg gcctcaacaa gcaaggctac

421 aaatgcaggc aatgtaacgc tgccatccac aagaaatgca tcgacaagat catcggcaga

481 tgcactggca ccgcggccaa cagccgggac actatattcc agaaagaacg cttcaacatc

541 gacatgccgc accgcttcaa ggttcacaac tacatgagcc ccaccttctg tgaccactgc

601 ggcagcctgc tctggggact ggtgaagcag ggattaaagt gtgaagactg cggcatgaat

661 gtgcaccata aatgccggga gaaggtggcc aacctctgcg gcatcaacca gaagcttttg

721 gctgaggcct tgaaccaagt cacccagaga gcctcccgga gatcagactc agcctcctca

781 gagcctgttg ggatatatca gggtttcgag aagaagaccg gagttgctgg ggaggacatg

841 caagacaaca gtgggaccta cggcaagatc tgggagggca gcagcaagtg caacatcaac

901 aacttcatct tccacaaggt cctgggcaaa ggcagcttcg ggaaggtgct gcttggagag

961 ctgaagggca gaggagagta ctttgccatc aaggccctca agaaggatgt ggtcctgatc

1021 gacgacgacg tggagtgcac catggttgag aagcgggtgc tgacacttgc cgcagagaat

1081 ccctttctca cccacctcat ctgcaccttc cagaccaagg accacctgtt ctttgtgatg

1141 gagttcctca acggggggga cctgatgtac cacatccagg acaaaggccg ctttgaactc

1201 taccgtgcca cgttttatgc cgctgagata atgtgtggac tgcagtttct acacagcaag

1261 ggcatcattt acagggacct caaactggac aatgtgctgt tggaccggga tggccacatc

1321 aagattgccg actttgggat gtgcaaagag aacatattcg gggagagccg ggccagcacc

1381 ttctgcggca cccctgacta tatcgcccct gagatcctac agggcctgaa gtacacattc

1441 tctgtggact ggtggtcttt cggggtcctt ctgtacgaga tgctcattgg ccagtccccc

1501 ttccatggtg atgatgagga tgaactcttc gagtccatcc gtgtggacac gccacattat

1561 ccccgctgga tcaccaagga gtccaaggac atcctggaga agctctttga aagggaacca

1621 accaagaggc tgggagtgac gggaaacatc aaaatccacc ccttcttcaa gaccataaac

1681 tggactctgc tggaaaagcg gaggttggag ccacccttca ggcccaaagt gaagtcaccc

1741 agagactaca gtaactttga ccaggagttc ctgaacgaga aggcgcgcct ctcctacagc

1801 gacaagaacc tcatcgactc catggaccag tctgcattcg ctggcttctc ctttgtgaac

1861 cccaaattcg agcacctcct ggaagattga ggttcctgga cagatcaggc tagccctgcc

1921 ctccacccac acctgcccgc tccccacgat aagcaccagt gggactgtgg tgacttctgc

1981 tgctggcccc gcccctgccc ccagagcgtc cttggctgcc gtctggccgg gctctcatgg

2041 tacttcctct gtgaactgtg tgtgaatctg cttttcctct gccttcggag ggaaattgta

2101 aatcctgtgt ttcattactt gaatgtagtt atctattgaa aatatacttt agagcacaat

2161 gga tgccgccgcg acccttggcg cctgcccctg caacgggagc cccactgcag gccccaccat

61 ggcgccgttc ctgcgcatcg ccttcaactc ctatgagctg ggctccctgc aggccgagga

121 cgaggcgaac cagcccttct gtgccgtgaa gatgaaggag gcgctcagca cagagcgtgg

181 gaaaacactg gtgcagaaga agccgaccat gtatcctgag tggaagtcga cgttcgatgc

241 ccacatctat gaggggcgcg tcatccagat tgtgctaatg cgggcagcag aggagccagt

301 gtctgaggtg accgtgggtg tgtcggtgct ggccgagcgc tgcaagaaga acaatggcaa

361 ggctgagttc tggctggacc tgcagcctca ggccaaggtg ttgatgtctg ttcagtattt

421 cctggaggac gtggattgca aacaatctat gcgcagtgag gacgaggcca agttcccaac

481 gatgaaccgc cgcggagcca tcaaacaggc caaaatccac tacatcaaga accatgagtt

541 tatcgccacc ttctttgggc aacccacctt ctgttctgtg tgcaaagact ttgtctgggg

601 cctcaacaag caaggctaca aatgcaggca atgtaacgct gccatccaca agaaatgcat

661 cgacaagatc atcggcagat gcactggcac cgcggccaac agccgggaca ctatattcca

721 gaaagaacgc ttcaacatcg acatgccgca ccgcttcaag gttcacaact acatgagccc

781 caccttctgt gaccactgcg gcagcctgct ctggggactg gtgaagcagg gattaaagtg

841 tgaagactgc ggcatgaatg tgcaccataa atgccgggag aaggtggcca acctctgcgg

901 catcaaccag aagcttttgg ctgaggcctt gaaccaagtc acccagagag cctcccggag

961 atcagactca gcctcctcag agcctgttgg gatatatcag ggtttcgaga agaagaccgg

1021 agttgctggg gaggacatgc aagacaacag tgggacctac ggcaagatct gggagggcag

1081 cagcaagtgc aacatcaaca acttcatctt ccacaaggtc ctgggcaaag gcagcttcgg

1141 gaaggtgctg cttggagagc tgaagggcag aggagagtac tctgccatca aggccctcaa

1201 gaaggatgtg gtcctgatcg acgacgacgt ggagtgcacc atggttgaga agcgggtgct

1261 gacacttgcc gcagagaatc cctttctcac ccacctcatc tgcaccttcc agaccaagga

1321 ccacctgttc tttgtgatgg agttcctcaa cgggggggac ctgatgtacc acatccagga

1381 caaaggccgc tttgaactct accgtgccac gttttatgcc gctgagataa tgtgtggact

1441 gcagtttcta cacagcaagg gcatcattta cagggacctc aaactggaca atgtgctgtt

1501 ggaccgggat ggccacatca agattgccga ctttgggatg tgcaaagaga acatattcgg

1561 ggagagccgg gccagcacct tctgcggcac ccctgactat atcgcccctg agatcctaca

1621 gggcctgaag tacacattct ctgtggactg gtggtctttc ggggtccttc tgtacgagat

1681 gctcattggc cagtccccct tccatggtga tgatgaggat gaactcttcg agtccatccg

1741 tgtggacacg ccacattatc cccgctggat caccaaggag tccaaggaca tcctggagaa

1801 gctctttgaa agggaaccaa ccaagaggct gggaatgacg ggaaacatca aaatccaccc

1861 cttcttcaag accataaact ggactctgct ggaaaagcgg aggttggagc cacccttcag

1921 gcccaaagtg aagtcaccca gagactacag taactttgac caggagttcc tgaacgagaa

1981 ggcgcgcctc tcctacagcg acaagaacct catcgactcc atggaccagt ctgcattcgc

2041 tggcttctcc tttgtgaacc ccaaattcga gcacctcctg gaagattgag gttcctggac

2101 agat cccaagatgg aagggagcgg cggccgcgtc cgcctcaagg cgcattacgg gggggacatc

61 ttcatcacca gcgtggacgc cgccacgacc ttcgaggagc tctgtgagga agtgagagac

121 atgtgtcgtc tgcaccagca gcacccgctc accctcaagt gggtggacag cgaaggtgac

181 ccttgcacgg tgtcctccca gatggagctg gaagaggctt tccgcctggc ccgtcagtgc

241 agggatgaag gcctcatcat tcatgttttc ccgagcaccc ctgagcagcc tggcctgcca

301 tgtccgggag aagacaaatc tatctaccgc cggggagcca gaagatggag gaagctgtac

361 cgtgccaacg gccacctctt ccaagccaag cgctttaaca ggagagcgta ctgcggtcag

421 tgcagcgaga ggatatgggg cctcgcgagg caaggctaca ggtgcatcaa ctgcaaactg

481 ctggtccata agcgctgcca cggcctcgtc ccgctgacct gcaggaagca tatggattct

541 gtcatgcctt cccaagagcc tccagtagac gacaagaacg aggacgccga ccttccttcc

601 gaggagacag atggaattgc ttacatttcc tcatcccgga agcatgacag cattaaagac

661 gactcggagg accttaagcc agttatcgat gggatggatg gaatcaaaat ctctcagggg

721 cttgggctgc aggactttga cctaatcaga gtcatcgggc gcgggagcta cgccaaggtt

781 ctcctggtgc ggttgaagaa gaatgaccaa atttacgcca tgaaagtggt gaagaaagag

841 ctggtgcatg atgacgagga tattgactgg gtacagacag agaagcacgt gtttgagcag

901 gcatccagca accccttcct ggtcggatta cactcctgct tccagacgac aagtcggttg

961 ttcctggtca ttgagtacgt caacggcggg gacctgatgt tccacatgca gaggcagagg

1021 aagctccctg aggagcacgc caggttctac gcggccgaga tctgcatcgc cctcaacttc

1081 ctgcacgaga gggggatcat ctacagggac ctgaagctgg acaacgtcct cctggatgcg

1141 gacgggcaca tcaagctcac agactacggc atgtgcaagg aaggcctggg ccctggtgac

1201 acaacgagca ctttctgcgg aaccccgaat tacatcgccc ccgaaatcct gcggggagag

1261 gagtacgggt tcagcgtgga ctggtgggcg ctgggagtcc tcatgtttga gatgatggcc

1321 gggcgctccc cgttcgacat catcaccgac aacccggaca tgaacacaga ggactacctt

1381 ttccaagtga tcctggagaa gcccatccgg atcccccggt tcctgtccgt caaagcctcc

1441 catgttttaa aaggattttt aaataaggac cccaaagaga ggctcggctg ccggccacag

1501 actggatttt ctgacatcaa gtcccacgcg ttcttccgca gcatagactg ggacttgctg

1561 gagaagaagc aggcgctccc tccattccag ccacagatca cagacgacta cggtctggac

1621 aactttgaca cacagttcac cagcgagccc gtgcagctga ccccagacga tgaggatgcc

1681 ataaagagga tcgaccagtc agagttcgaa ggctttgagt atatcaaccc attattgctg

1741 tccaccgagg agtcggtgtg aggccgcgtg cgtctctgtc gtggacacgc gtgattgacc

1801 ctttaactgt atccttaacc accgcatatg catgccaggc tgggcacggc tccgagggcg

1861 gccagggaca gacgcttgcg ccgagaccgc agagggaagc gtcagcgggc gctgctggga 1921 gcagaacagt ccctcacacc tggcccggca ggcagcttcg tgctggagga acttgctgct

1981 gtgcctgcgt cgcggcggat ccgcggggac cctgccgagg gggctgtcat gcggtttcca

2041 aggtgcacat tttccacgga aacagaactc gatgcactga cctgctccgc caggaaagtg

2101 agcgtgtagc gtcctgagga ataaaatgtt ccgatgaaaa aaaaaa gggccggcgg cggcggcgac tctggacgcg agccgggccc ttcccgtgga tcgccccagc

61 tgcggcgggc gtcgcggccg cccccgggtg gcacttccgt gtgccgcggc gccggagccc

121 gaggcggctg tagcccacat ctcccgagcg acccccggcg cccgcccgcc gcgcggaggc

181 ccgggccaca cctcactggc cgcttggccc atcccagtca gcgccgcgcc gaaccccgtc

241 cgcgcgcgcc ggggagcggc gcccccgccg ctgccgccgc gacccttggc gcctgcccct

301 gcaacgggag ccccactgca ggccccacca tggcgccgtt cctgcgcatc gccttcaact

361 cctatgagct gggctccctg caggccgagg acgaggcgaa ccagcccttc tgtgccgtga

421 agatgaagga ggcgctcagc acagagcgtg ggaaaacact ggtgcagaag aagccgacca

481 tgtatcctga gtggaagtcg acgttcgatg cccacatcta tgaggggcgc gtcatccaga

541 ttgtgctaat gcgggcagca gaggagccag tgtctgaggt gaccgtgggt gtgtcggtgc

601 tggccgagcg ctgcaagaag aacaatggca aggctgagtt ctggctggac ctgcagcctc

661 aggccaaggt gttgatgtct gttcagtatt tcctggagga cgtggattgc aaacagtcta

721 tgcgcagtga ggacgaggcc aagttcccaa cgatgaaccg ccgcggagcc atcaaacagg

781 ccaaaatcca ctacatcaag aaccatgagt ttatcgccac cttctttggg caacccacct

841 tctgttctgt gtgcaaagac tttgtctggg gcctcaacaa gcaaggctac aaatgcaggc

901 aatgtaacgc tgccatccac aagaaatgca tcgacaagat catcggcaga tgcactggca

961 ccgcggccaa cagccgggac actatattcc agaaagaacg cttcaacatc gacatgccgc

1021 accgcttcaa ggttcacaac tacatgagcc ccaccttctg tgaccactgc ggcagcctgc

1081 tctggggact ggtgaagcag ggattaaagt gtgaagactg cggcatgaat gtgcaccata

1141 aatgccggga gaaggtggcc aacctctgcg gcatcaacca gaagcttttg gctgaggcct

1201 tgaaccaagt cacccagaga gcctcccgga gatcagactc agcctcctca gagcctgttg

1261 ggatatatca gggtttcgag aagaagaccg gagttgctgg ggaggacatg caagacaaca

1321 gtgggaccta cggcaagatc tgggagggca gcagcaagtg caacatcaac aacttcatct

1381 tccacaaggt cctgggcaaa ggcagcttcg ggaaggtgct get ctccccgccc cgaccatggt agtgttcaat ggccttctta agatcaaaat ctgcgaggcc

61 gtgagcttga agcccacagc ctggtcgctg cgccatgcgg tgggaccccg gccgcagact

121 ttccttctcg acccctacat tgccctcaat gtggacgact cgcgcatcgg ccaaacggcc

181 accaagcaga agaccaacag cccggcctgg cacgacgagt tcgtcaccga tgtgtgcaac

241 ggacgcaaga tcgagctggc tgtctttcac gatgccccca taggctacga cgacttcgtg

301 gccaactgca ccatccagtt tgaggagctg ctgcagaacg ggagccgcca cttcgaggac

361 tggattgatc tggagccaga aggaagagtg tatgtgatca tcgatctctc agggtcgtcg

421 ggtgaagccc ctaaagacaa tgaagagcgt gtgttcaggg aacgcatgcg gccgaggaag

481 cggcaggggg ccgtcaggcg cagggtccat caggtcaacg gccacaagtt catggccacc

541 tatcttcggc agcccaccta ctgctcccat tgcagagact tcatctgggg tgtcatagga

601 aagcagggat accagtgtca agtctgcacc tgcgtggtcc acaagcggtg ccacgagctc

661 ataatcacaa aaggttggttggccttgggg ggttttaaaaaaggaaaagg caggagaccc ccgaccaggt gggctcccag

721 cggttcagcg tcaacatgcc ccacaagttc ggtatccaca actacaaggt ccctaccttc

78 811 tgcgatcact gtgggtccct gctctgggga ctcttgcggc agggtttgca gtgtaaagtc

841 tgcaaaatga atgttcaccg tcgatgtgag accaacgtgg ctcccaactg tggagtggat

901 gccagaggaa tcgccaaagt actggccgac ctgggcgtta ccccagacaa aatcaccaac

961 agcggccaga gaaggaaaaa gctcattgct ggtgccgagt ccccgcagcc tgcttctgga

1021 agctcaccat ctgaggaaga tcgatccaag tcagcaccca cctccccttg tgaccaggaa

1081 ataaaagaac ttgagaacaa cattcggaaa gccttgtcat ttgacaaccg aggagaggag

1141 caccgggcag catcgtctcc tgatggccag ctgatgagcc ccggtgagaa tggcgaagtc

1201 cggcaaggcc aggccaagcg cctgggcctg gatgagttca acttcatcaa ggtgttgggc

1261 aaaggcagct ttggcaaggt catgttggca gaactcaagg gcaaagatga agtatatgct

1321 gtgaaggtct taaagaagga cgtcatcctt caggatgatg acgtggactg cacaatgaca

1381 gagaagagga ttttggctct ggcacggaaa cacccgtacc ttacccaact ctactgctgc

1441 ttccagacca aggaccgcct ctttttcgtc atggaatatg taaatggtgg agacctcatg

1501 tttcagattc agcgctcccg aaaattcgac gagcctcgtt cacggttcta tgctgcagag

1561 gtcacatcgg ccctcatgtt cctccatcag catggagtca tctacaggga tttgaaactg

1621 gacaacatcc ttctggatgc agaaggtcac tgcaagctgg ctgacttcgg gatgtgcaag

1681 gaagggattc tgaatggtgt gacgaccacc acgttctgtg ggactcctga ctacatagct

1741 cctgagatcc tgcaggagtt ggagtatggc ccctccgtgg actggtgggc cctgggggtg

1801 ctgatgtacg agatgatggc tggacagcct ccctttgagg ccgacaatga ggacgaccta

1861 tttgagtcca tcctccatga cgacgtgctg tacccagtct ggctcagcaa ggaggctgtc

1921 agcatcttga aagctttcat gacgaagaat ccccacaagc gcctgggctg tgtggcatcg

1981 cagaatggcg aggacgccat caagcagcac ccattcttca aagagattga ctgggtgctc

2041 ctggagcaga agaagatcaa gccacccttc aaaccacgca ttaaaaccaa aagagacgtc

2101 aataattttg accaagactt tacccgggaa gagccggtac tcacccttgt ggacgaagca

2161 attgtaaagc agatcaacca ggaggaattc aaaggtttct cctactttgg tgaagacctg

2221 atgccctgag agcccactgc agtt agccggcttc tggaaactcc ctgtgtgagt gtgagggaat gagtatgaac aaggcacatt

61 atgtcttact tattgtatta gtttcctgtt gctgctgtag caagttacca ccaatttatg 121 gcttaaagca attcaaattt tttctcttga attcttaaga tcagaagttc taaatgagtc 181 taatggggct aaaatcaagg tgttaggcaa aggcagct tgcagctgga gatccgggct cccacagcag atgagatcca cgtaactgtt ggcgaggccc

61 gtaacctaat tcctatggac cccaatggtc tctctgatcc ctatgtgaaa ctgaagctca

121 tcccagaccc tcggaacctg acgaaacaga agacccgaac ggtgaaagcc acgctaaacc

181 ctgtgtggaa tgagaccttt gtgttcaacc tgaagccagg ggatgtggag cgccggctca

241 gcgtggaggt gtgggactgg gaccggacct cccgcaacga cttcatgggg gccatgtcct

301 ttggcgtctc ggagctgctc aaggcgcccg tggatggctg gtacaagtta ctgaaccagg

361 aggagggcga gtattacaat gtgccggtgg ccgatgctga caactgcagc ctcctccaga

421 agtttgaggc ttgtaactac cccctggaat tgtatgagcg ggtgcggatg ggcccctctt

481 cctctcccat cccctcccct tcccctagtc ccaccgaccc caagcgctgc ttcttcgggg

541 cgagtccagg acgcctgcac atctccgact tcagcttcct catggttcta ggaaaaggca

601 gttttgggaa ggtgatgctg gccgagcgca ggggctctga tgagctctac gccatcaaga

661 tcttgaaaaa ggacgtgatc gtccaggacg acgatgtgga ctgcacgctg gtggagaaac

721 gtgtgctggc gctggggggc cggggtcctg gcggccggcc ccacttcctc acccagctcc

781 actccacctt ccagaccccg gaccgcctgt atttcgtgat ggagtacgtc accgggggag

841 acttgatgta ccacattcaa cagctgggca agtttaagga gccccatgca gcgttctacg

901 cggcagaaat cgctatcggc ctcttcttcc ttcacaatca gggcatcatc tacagggacc

961 tgaagctgga caatgtgatg ctggatgctg agggacacat caagatcact gactttggca

1021 tgtgtaagga gaacgtcttc cccgggacga caacccgcac cttctgcggg accccggact

1081 acatagcccc ggagatcatt gcctaccagc cctatgggaa gtctgtcgat tggtggtcct

1141 ttggagttct gctgtatgag atgttggcag gacagcctcc cttcgatggg gaggacgagg

1201 aggagctgtt tcaggccatc atggaacaaa ctgtcaccta ccccaagtcg ctttcccggg

1261 aagccgtggc catctgcaag gggttcctga ccaagcaccc agggaagcgc ctgggctcag

1321 ggcctgatgg ggaacctacc atccgtgcac atggcttttt ccgctggatt gactgggagc

1381 ggctggaacg attggagatc ccgcctcctt tcagaccccg cccgtgtggc cgcagcggcg

1441 agaactttga caagttcttc acgcgggcgg cgccagcgct gacccctcca gaccgcctag

1501 tcctggccag catcgaccag gccgatttcc agggcttcac ctacgtgaac cccgacttcg

1561 tgcacccgga tgcccgcagc cccaccagcc cagtgcctgt gcccgtcatg taatctcacc

1621 cgccgccact aggtgtcccc aacgtcccct ccgccgtgcc ggcggcagcc ccacttcacc

1681 cccaacttca ccaccccctg tcccattcta gatcctgcac cccagcattc cagctctgcc

1741 cccgcgggtt ctagacgccc ctcccaagcg ttcctggcct tctgaactcc atacagcctc

1801 tacagccgtc ccgcgttcaa gacttgagcg cggggtgtct tgggcccggg cggctgtaga ggcggcggcg cctacgggca gtgggaggag

61 ccgcgcggtt ccggctgctc cggcgaggcg acccttgggt cggcgctgcg ggcaggtggc

121 aggtaggtgg cggacggccg cggttctccg gcaagcgcag gcggcggagt cccccacggc

181 gcccgaagcg cccccccgca cccccggcct ccagcgttga ggcgggggag tgaggagatg

241 ccgacccaga gggacagcag caccatgtcc cacacggtcg caggcggcgg cagcggggac

301 cattcccacc aggtccgggt gaaagcctac taccgcgggg atatcatgat aacacatttt

361 gaaccttcca tctcctttga gggcctttgc aatgaggttc gagacatgtg ttcttttgac

421 aacgaacagc tcttcaccat gaaatggata gatgaggaag gagacccgtg tacagtatca

481 tctcagttgg agttagaaga agcctttaga ctttatgagc taaacaagga ttctgaactc

541 ttgattcatg tgttcccttg tgtaccagaa cgtcctggga tgccttgtcc aggagaagat

601 aaatccatct accgtagagg tgcacgccgc tggagaaagc tttattgtgc caatggccac

661 actttccaag ccaagcgttt caacaggcgt gctcactgtg ccatctgcac agaccgaata

721 tggggacttg gacgccaagg atataagtgc atcaactgca aactcttggt tcataagaag

781 tgccataaac tcgtcacaat tgaatgtggg cggcattctt tgccacagga accagtgatg

841 cccatggatc agtcatccat gcattctgac catgcacaga cagtaattcc atataatcct

901 tcaagtcatg agagtttgga tcaagttggt gaagaaaaag aggcaatgaa caccagggaa

961 agtggcaaag cttcatccag tctaggtctt caggattttg atttgctccg ggtaatagga

1021 agaggaagtt atgccaaagt actgttggtt cgattaaaaa aaacagatcg tatttatgca

1081 atgaaagttg tgaaaaaaga gcttgttaat gatgatgagg atattgattg ggtacagaca

1141 gagaagcatg tgtttgagca ggcatccaat catcctttcc ttgttgggct gcattcttgc

1201 tttcagacag aaagcagatt gttctttgtt atagagtatg taaatggagg agacctaatg

1261 tttcatatgc agcgacaaag aaaacttcct gaagaacatg ccagatttta ctctgcagaa

1321 atcagtctag cattaaatta tcttcatgag cgagggataa tttatagaga tttgaaactg

1381 gacaatgtat tactggactc tgaaggccac attaaactca ctgactacgg catgtgtaag

1441 gaaggattac ggccaggaga tacaaccagc actttctgtg gtactcctaa ttacattgct

1501 cctgaaattt taagaggaga agattatggt ttcagtgttg actggtgggc tcttggagtg

1561 ctcatgtttg agatgatggc aggaaggtct ccatttgata ttgttgggag ctccgataac

1621 cctgaccaga acacagagga ttatctcttc caagttattt tggaaaaaca aattcgcata

1681 ccacgttctc tgtctgtaaa agctgcaagt gttctgaaga gttttcttaa taaggaccct

1741 aaggaacgat tgggttgtca tcctcaaaca ggatttgctg atattcaggg acacccgttc

1801 ttccgaaatg ttgattggga tatgatggag caaaaacagg tggtacctcc ctttaaacca

1861 aatatttctg gggaatttgg tttggacaac tttgattctc agtttactaa tgaacctgtc

1921 cagctcactc cagatgacga tgacattgtg aggaagattg atcagtctga atttgaaggt

1981 tttgagtata tcaatcctct tttgatgtct gcagaagaat gtgtctgatc ctcatttttc

2041 aaccatgtat tctactcatg ttgccattta atgcatggat aaacttgctg caagcctgga 2101 tacaattaac cattttatat ttgccaccta caaaaaaaca cccaatatct tctcttgtag 2161 actatatgaa tcaattatta catctcgacc cggaat gaattcggac ggaggaggca gaatggccag tcgaggggcg cttaggcgtg gcctttcccc

61 agggctgcct cgactcctgc acctgtcccg agggctggcc tgagacggga ctcccggttc

121 tcccgctgcg aagcaggccc cccggggccg gggcagcggc gccggcatgt cgtctggcac

181 catgaagttc aatggctatt tgagggtccg catcggtgag gcagtggggc tgcagcccac

241 ccgctggtcc ctgcgccact cgctcttcaa gaagggccac cagctgctgg acccctatct

301 gacggtgagc gtggaccagg tgcgcgtggg ccagaccagc accaagcaga agaccaacaa

361 acccacgtac aacgaggagt tttgcgctaa cgtcaccgac ggcggccacc tcgagttggc

421 cgtcttccac gagacccccc tgggctacga cttcgtggcc aactgcaccc tgcagttcca

481 ggagctcgtc ggcacgaccg gcgcctcgga caccttcgag ggttgggtgg atctcgagcc

541 agaggggaaa gtatttgtgg taataaccct taccgggagt ttcactgaag ctactctcca

601 gagagaccgg atcttcaaac attttaccag gaagcgccaa agggctatgc gaaggcgagt

661 ccaccagatc aatggacaca agttcatggc cacgtatctg aggcagccca cctactgctc

721 tcactgcagg gagtttatct ggggagtgtt tgggaaacag ggttatcagt gccaagtgtg

781 cacctgtgtc gtccataaac gctgccatca tctaattgtt acagcctgta cttgccaaaa

841 caatattaac aaagtggatt caaagattgc agaacagagg ttcgggatca acatcccaca

901 caagttcagc atccacaact acaaagtgcc aacattctgc gatcactgtg gctcactgct

961 ctggggaata atgcgacaag gacttcagtg taaaatatgt aaaatgaatg tgcatattcg

1021 atgtcaagcg aacgtggccc ctaactgtgg ggtaaatgcg gtggaacttg ccaagaccct

1081 ggcagggatg ggtctccaac ccggaaatat ttctccaacc tcgaaactcg tttccagatc

1141 gaccctaaga cgacagggaa aggagagcag caaagaagga aatgggattg gggttaattc

1201 ttccaaccga cttggtatcg acaactttga gttcatccga gtgttgggga aggggagttt

1261 tgggaaggtg atgcttgcaa gagtaaaaga aacaggagac ctctatgctg tgaaggtgct

1321 gaagaaggac gtgattctgc tggatgatga tgtggaatgc accatgaccg agaaaaggat

1381 cctgtctctg gcccgcaatc accccttcct cactcagttg ttctgctgct ttcagacccc

1441 cgatcgtctg ttttttgtga tggagtttgt gaatgggggt gacttgatgt tccacattca

1501 gaagtctcgt cgttttgatg aagcacgagc tcgcttctat gctgcagaaa tcatttcggc

1561 tctcatgttc ctccatgata aaggaatcat ctatagagat ctgaaactgg acaatgtcct

1621 gttggaccac gagggtcact gtaaactggc agacttcgga atgtgcaagg aggggatttg

1681 caatggtgtc accacggcca cattctgtgg cacgccagac tatatcgctc cagagatcct

1741 ccaggaaatg ctgtacgggc ctgcagtaga ctggtgggca atgggcgtgt tgctctatga

1801 gatgctctgt ggtcacgcgc cttttgaggc agagaatgaa gatgacctct ttgaggccat

1861 actgaatgat gaggtggtct accctacctg gctccatgaa gatgccacag ggatcctaaa

1921 atctttcatg accaagaacc ccaccatgcg cttgggcagc ctgactcagg gaggcgagca

1981 cgccatcttg agacatcctt tttttaagga aatcgactgg gcccagctga accatcgcca

2041 aatagaaccg cctttcagac ccagaatcaa atcccgagaa gatgtcagta attttgaccc

2101 tgacttcata aaggaagagc cagttttaac tccaattgat gagggacatc ttccaatgat

2161 taaccaggat gagtttagaa acttttccta tgtgtctcca gaattgcaac catagcctta

2221 tggggagtga gagagagggc acgagaaccc aaaggaatag agattctcca ggaatttcct

2281 ctatcggacc ttcccagcat cagccttaga acaagaacct taccttcaag gagcaagtga

2341 agaactctgt cgaaggatgg aactttcaga tatcaactat ttagagtcc gaattccttc tctcctcctc ctcgcccttc tcctcgccct cctcctcctc ctcgccctcc

61 cctcccgatc ctcatcccct tgccctcccc cagcccaggg acttttccgg aaagttttta

121 ttttccgtct gggctctcgg agaaagaagc tcctggctca gcggctgcaa aactttcctg

181 ctgccgcgcc gccagccccc gccctccgct gcccggccct gcgccccgcc gagcgatgag

241 cgcccctccg gtcctgcggc cgcccagtcc gctgctgccc gtggcggcgg cagctgccgc

301 agcggccgcc gcactggtcc cagggtccgg gcccgggccc gcgccgttct tggctcctgt

361 cgcggccccg gtcgggggca tctcgttcca tctgcagatc ggcctgagcc gtgagccggt

421 gctgctgctg caggactcgt ccggggacta cagcctggcg cacgtccgcg agatggcttg

481 ctccattgtc gaccagaagt tccctgaatg tggtttctac ggaatgtatg ataagatcct

541 gctttttcgc catgacccta cctctgaaaa catccttcag ctggtgaaag cggccagtga

601 tatccaggaa ggcgatctta ttgaagtggt cttgtcacgt tccgccacct ttgaagactt

661 tcagattcgt ccccacgctc tctttgttca ttcatacaga gctccagctt tctgtgatca

721 ctgtggagaa atgctgtggg ggctggtacg tcaaggtctt aaatgtgaag ggtgtggtct

781 gaattaccat aagagatgtg catttaaaat acccaacaat tgcagcggtg tgaggcggag

841 aaggctctca aacgtttccc tcactggggt cagcaccatc cgcacatcat ctgctgaact

901 ctctacaagt gcccctgatg agccccttct gcaaaaatca ccatcagagt cgtttattgg

961 tcgagagaag aggtcaaatt ctcaatcata cattggacga ccaattcacc ttgacaagat

1021 tttgatgtct aaagttaaag tgccgcacac atttgtcatc cactcctaca cccggcccac

1081 agtgtgccag tactgcaaga agcttctgaa ggggcttttc aggcagggct tgcagtgcaa

1141 agattgcaga ttcaactgcc ataaacgttg tgcaccgaaa gtaccaaaca actgccttgg

1201 cgaagtgacc attaatggag atttgcttag ccctggggca gagtctgatg tggtcatgga

1261 agaagggagt gatgacaatg atagtgaaag gaacagtggg ctcatggatg atatggaaga

1321 agcaatggtc caagatgcag agatggcaat ggcagagtgc cagaacgaca gtggcgagat

1381 gcaagatcca gacccagacc acgaggacgc caacagaacc atcagtccat caacaagcaa

1441 caatatccca ctcatgaggg tagtgcagtc tgtcaaacac acgaagagga aaagcagcac

1501 agtcatgaaa gaaggatgga tggtccacta caccagcaag gacacgctgc ggaaacggca 1561 ctattggaga ttggatagca aatgtattac cctctttcag aatgacacag gaagcaggta 1621 ctacaaggaa attcctttat ctgaaatttt gtctctggaa ccagtaaaaa cttcagcttt 1681 aattcctaat ggggccaatc ctcattgttt cgaaatcact acggcaaatg tagtgtatta 1741 tgtgggagaa aatgtggtca atccttccag cccatcacca aataacagtg ttctcaccag 1801 tggcgttggt gcagatgtgg ccaggatgtg ggagatagcc atccagcatg cccttatgcc 1861 cgtcattccc aagggctcct ccgtgggtac aggaaccaac ttgcacagag atatctctgt 1921 gagtatttca gtatcaaatt gccagattca agaaaatgtg gacatcagca cagtatatca 1981 gatttttcct gatgaagtac tgggttctgg acagtttgga attgtttatg gaggaaaaca 2041 tcgtaaaaca ggaagagatg tagctattaa aatcattgac aaattacgat ttccaacaaa 2101 acaagaaagc cagcttcgta atgaggttgc aattctacag aaccttcatc accctggtgt 2161 tgtaaatttg gagtgtatgt ttgagacgcc tgaaagagtg tttgttgtta tggaaaaact 2221 ccatggagac atgctggaaa tgatcttgtc aagtgaaaag ggcaggttgc cagagcacat 2281 aacgaagttt ttaattactc agatactcgt ggctttgcgg caccttcatt ttaaaaatat 2341 cgttcactgt gacctcaaac cagaaaatgt gttgctagcc tcagctgatc cttttcctca 2401 ggtgaaactt tgtgattttg gttttgcccg gatcattgga gagaagtctt tccggaggtc 2461 agtggtgggt acccccgctt acctggctcc tgaggtccta aggaacaagg gctacaatcg 2521 ctctctagac atgtggtctg ttggggtcat catctatgta agcctaagcg gcacattccc 2581 atttaatgaa gatgaagaca tacacgacca aattcagaat gcagctttca tgtatccacc 2641 aaatccctgg aaggaaatat ctcatgaagc cattgatctt atcaacaatt tgctgcaagt 2701 aaaaatgaga aagcgctaca gtgtggataa gaccttgagc cacccttggc tacaggacta 2761 tcagacctgg ttagatttgc gagagctgga atgcaaaatc ggggagcgct acatcaccca 2821 tgaaagtgat gacctgaggt gggagaagta tgcaggcgag cagcggctgc agtaccccac 2881 acacctgatc aatccaagtg ctagccacag tgacactcct gagactgaag aaacagaaat 2941 gaaagccctc ggtgagcgtg tcagcatcct ctgagttcca tctcctataa tctgtcaaaa 3001 cactgtggaa ctaataaata catacggtca ggtttaacat ttgccttgca gaactgccat 3061 tattttctgt cagatgagaa caaagctgtt aaactgttag cactgttgat gtatctgagt 3121 tgccaagaca aatcaacaga agcatttgta ttttgtgtga ccaactgtgt tgtattaaca 3181 aaagttccct gaaacacgaa acttgttatt gtgaatgatt catgttatat ttaatgcatt 3241 aaacctgtct ccactgtgcc tttgcaaatc agtgtttttc ttactggagc ttcattttgg 3301 taagagacag aatgtatctg tgaagtagtt ctgtttggtg tgtcccattg gtgttgtcat 3361 tgtaaacaaa ctcttgaaga gtcgattatt tccagtgttc tatgaacaac tccaaaaccc 3421 atgtgggaaa aaaatgaatg aggagggtag ggaataaaat cctaagacac aaatgcatga 3481 acaagtttta atgtatagtt ttgaatcctt tgcctgcctg gtgtgcctca gtatatttaa 3541 actcaagaca atgcacctag ctgtgcaaga cctagtgctc ttaagcctaa atgccttaga 3601 aatgtaaact gccatatata acagatacat ttccctcttt cttataatac tctgttgtac 3661 tatggaaaat cagctgctca gcaacctttc acctttgtgt atttttcaat aataaaaaat 3721 attcttgtca aaaaaaaaaa aa tgctcgctcc agggcgcaac catgtcgcca tttcttcgga ttggcttgtc caactttgac

61 tgcgggtcct gccagtcttg tcagggcgag gctgttaacc cttactgtgc tgtgctcgtc

121 aaagagtatg tcgaatcaga gaacgggcag atgtatatcc agaaaaagcc taccatgtac

181 ccaccctggg acagcacttt tgatgcccat atcaacaagg gaagagtcat gcagatcatt

241 gtgaaaggca aaaacgtgga cctcatctct gaaaccaccg tggagctcta ctcgctggct

301 gagaggtgca ggaagaacaa cgggaagaca gaaatatggt tagagctgaa acctcaaggc

361 cgaatgctaa tgaatgcaag atactttctg gaaatgagtg acacaaagga catgaatgaa

421 tttgagacgg aaggcttctt tgctttgcat cagcgccggg gtgccatcaa gcaggcaaag

481 gtccaccacg tcaagtgcca cgagttcact gccaccttct tcccacagcc cacattttgc

541 tctgtctgcc acgagtttgt ctggggcctg aacaaacagg gctaccagtg ccgacaatgc

601 aatgcagcaa ttcacaagaa gtgtattgat aaagttatag caaagtgcac aggatcagct

661 atcaatagcc gagaaaccat gttccacaag gagagattca aaattgacat gccacacaga

721 tttaaagtct acaattacaa gagcccgacc ttctgtgaac actgtgggac cctgctgtgg

781 ggactggcac ggcaaggact caagtgtgat gcatgtggca tgaatgtgca tcatagatgc

841 cagacaaagg tggccaacct ttgtggcata aaccagaagc taatggctga agcgctggcc

901 atgattgaga gcactcaaca ggctcgctgc ttaagagata ctgaacagat cttcagagaa

961 ggtccggttg aaattggtct cccatgctcc atcaaaaatg aagcaaggcc gccatgttta

1021 ccgacaccgg gaaaaagaga gcctcagggc atttcctggg agtctccgtt ggatgaggtg

1081 gataaaatgt gccatcttcc agaacctgaa ctgaacaaag aaagaccatc tctgcagatt

1141 aaactaaaaa ttgaggattt tatcttgcac aaaatgttgg ggaaaggaag ttttggcaag

1201 gtcttcctgg cagaattcaa gaaaaccaat caatttttcg caataaaggc cttaaagaaa

1261 gatgtggtct tgatggacga tgatgttgag tgcacgatgg tagagaagag agttctttcc

1321 ttggcctggg agcatccgtt tctgacgcac atgttttgta cattccagac caaggaaaac

1381 ctcttttttg tgatggagta cctcaacgga ggggacttaa tgtaccacat ccaaagctgc

1441 cacaagttcg acctttccag agcgacgttt tatgctgctg aaatcattct tggtctgcag

1501 ttccttcatt ccaaaggaat agtctacagg gacctgaagc tagataacat cctgttagac

1561 aaagatggac atatcaagat cgcggatttt ggaatgtgca aggagaacat gttaggagat

1621 gccaagacga ataccttctg tgggacacct gactacatcg ccccagagat cttgctgggt

1681 cagaaataca accactctgt ggactggtgg tccttcgggg ttctccttta tgaaatgctg

1741 attggtcagt cgcctttcca cgggcaggat gaggaggagc tcttccactc catccgcatg

1801 gacaatccct tttacccacg gtggctggag aaggaagcaa aggaccttct ggtgaagctc 1861 ttcgtgcgag aacctgagaa gaggctgggc gtgaggggag acatccgcca gcaccctttg

1921 tttcgggaga tcaactggga ggaacttgaa cggaaggaga ttgacccacc gttccggccg

1981 aaagtgaaat caccatttga ctgcagcaat ttcgacaaag aattcttaaa cgagaagccc

2041 cggctgtcat ttgccgacag agcactgatc aacagcatgg accagaatat gttcaggaac

2101 ttttccttca tgaaccccgg gatggagcgg ctgatatcct gaatcttgcc cctccagaga

2161 caggaaagaa tttgccttct ccctgggaac tggttcaaga gacactgctt gggttccttt

2221 ttcaacttgg aaaaagaaag aaacactcaa caataaagac tgagacccgt tcgcccccat

2281 gtgactttat ctgtagcaga aaccaagtct acttcactaa tgacgatgcc gtgtgtctcg

2341 tctcctgaca tgtctcacag acgctcctga agttaggtca ttactaacca tagttattta

2401 cttgaaagat gggtctccgc acttggaaag gtttcaagac ttgatactgc aataaattat

2461 ggctcttcac ctgggcgcca actgctgatc aacgaaatgc ttgttgaatc aggggcaaac

2521 ggagtacaga cgtctcaaga ctgaaacggc cccattgcct ggtctagtag cggatctcac

2581 tcagccgcag acaagtaatc actaacccgt tttattctat cctatctgtg gatgtataaa

2641 tgctgggggc cagccctgga taggttttta tgggaattct ttacaataaa catagcttgt

2701 acttg atgcccagca ggaccgaccc caagatggaa gggagcggeg gccgcgtceg cctcaaggcg

61 cattacgggg gggacatctt catcaccagc gtggacgccg ccacgacctt cgaggagctc

121 tgtgaggaag tgagagacat gtgtcgtctg caccagcagc acccgctcac cctcaagtgg

181 gtggacagcg aaggtgaccc ttgcacggtg tcctcccaga tggagctgga agaggctttc

241 cgcctggccc gtcagtgcag ggatgaaggc ctcatcattc atgttttccc gagcacccct

301 gagcagcctg gcctgccatg tccgggagaa gacaaatcta tctaccgccg gggagccaga

361 agatggagga agctgtaccg tgccaacggc cacctcttcc aagccaagcg ctttaacagg

421 agagcgtact gcggtcagtg cagcgagagg atatggggcc tcgcgaggca aggctacagg

481 tgcatcaact gcaaactgct ggtccataag cgctgccacg gcctcgtccc gctgacctgc

541 aggaagcata tggattctgt catgccttcc caagagcctc cagtagacga caagaacgag

601 gacgccgacc ttccttccga ggagacagat ggaattgctt acatttcctc atcccggaag

661 catgacagca ttaaagacga ctcggaggac cttaagccag ttatcgatgg gatggatgga

721 atcaaaatct ctcaggggct tgggctgcag gactttgacc taatcagagt catcgggcgc

781 gggacgtacg ccaaggttct cctggtgcgg ttgaagaaga atgaccaaat ttacgccatg

841 aaagtggtga agaaagagct ggtgcatgat gacgaggata ttgactgggt acagacagag

901 aagcacgtgt ttgagcaggc atccagcaac cccttcctgg tcggattaca ctcctgcttc

961 cagacgacaa gtcggttgtt cctggtcatt gagtacgtca acggcgggga cctgatgttc

1021 cacatgcaga ggcagaggaa gctccctgag gagcacgcca ggttctacgc ggccgagatc

1081 tgcatcgccc tcaacttcct gcacgagagg gggatcatct acagggacct gaagctggac

1141 aacgtcctcc tggatgcgga cggacacatc aagctcacag actacggcat gtgcaaggaa

1201 ggcctgggcc ctggtgacac aacgagcact ttctgcggaa ccccgaatta catcgccccc

1261 gaaatcctgc ggggagagga gtacgggttc agcgtggact ggtgggcgct gggagtcctc

1321 atgtttgaga tgatggccgg gcgctccccg ttcgacatca tcaccgacaa cccggacatg

1381 aacacagagg actacctttt ccaagtgatc ctggagaagc ccatccggat cccccggttc

1441 ctgtccgtca aagcctccca tgttttaaaa ggatttttaa ataaggaccc caaagagagg

1501 ctcggctgcc ggccacagac tggattttct gacatcaagt cccacgcgtt cttccgcagc

1561 atagactggg acttgctgga gaagaagcag gcgctccctc cattccagcc acagatcaca

1621 gacgactacg gtctggacaa ctttgacaca cagttcacca gcgagcccgt gcagctgacc

1681 ccagacgatg aggatgccat aaagaggatc gaccagtcag agttcgaagg ctttgagtat

1741 atcaacccat tattgctgtc caccgaggag tcggtgtga

1 tgtcatgcct tcccaagagc ctccaggatg gctgtcctcc gacctcctcc acctccaggc

61 tctagatggc aaagcccact tagcaaaagc cacctgctct gtgatgatgg gactggctcc

121 tgcctgtggg ttcggaaagc ccatcccacc ctctacagcc tcttgctcct ctgcaatgac

181 tgtgccttca cctgggggtt ccccagagac tagtgagagt catcgggcgt ggaagctat

(2) INFORMATION FOR SEQ ID NO: 177: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1649 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 177: gccacttctt ctgggcccac gaggcagctg tcccatgctc tgctgagcac ggtggtgcca 61 tgcctctgca actcctcctg ttgctgatcc tactgggccc tggcaacagc ttgcagctgt 121 ^'gggacacctg ggcagatgaa gccgagaaag ccttgggtcc cctgcttgcc cgggaccgga 181 gacaggccac cgaatatgag tacctagatt atgatttcct gccagaaacg gagcctccag 241 aaatgctgag gaacagcact gacaccactc ctctgactgg gcctggaacc cctgagtcta 301 ccactgtgga gcctgctgca aggcgttcta ctggcctgga tgcaggaggg gcagtcacag 361 agctgaccac ggagctggcc aacatgggga acctgtccac ggattcagca gctatggaga 421 tacagaccac tcaaccagca gccacggagg cacagaccac tccactggca gccacagagg 481 cacagacaac tcgactgacg gccacggagg cacagaccac tccactggca gccacagagg 541 cacagaccac tccaccagca gccacggaag cacagaccac tcaacccaca ggcctggagg 601 cacagaccac tgcaccagca gccatggagg cacagaccac tgcaccagca gccatggaag 661 cacagaccac tccaccagca gccatggagg cacagaccac tcaaaccaca gccatggagg 721 cacagaccac tgcaccagaa gccacggagg cacagaccac tcaacccaca gccacggagg

781 cacagaccac tccactggca gccatggagg ccctgtccac agaacccagt gccacagagg

841 ccctgtccat ggaacctact accaaaagag gtctgttcat acccttttct gtgtcctctg

901 ttactcacaa gggcattccc atggcagcca gcaatttgtc cgtcaactac ccagtggggg

961 ccccagacca catctctgtg aagcagtgcc tgctggccat cctaatcttg gcgctggtgg

1021 ccactatctt cttcgtgtgc actgtggtgc tggcggtccg cctctcccgc aagggccaca

1081 tgtaccccgt gcgtaattac tcccccaccg agatggtctg catctcatcc ctgttgcctg

1141 atgggggtga ggggccctct gccacagcca atgggggcct gtccaaggcc aagagcccgg

1201 gcctgacgcc agagcccagg gaggaccgtg agggggatga cctcaccctg cacagcttcc

1261 tcccttagct cactctgcca tctgttttgg caagacccca cctccacggg ctctcctggg

1321 ccacccctga gtgcccagac cccaatccac agctctgggc ttcctcggag acccctgggg

1381 atggggatct tcagggaagg aactctggcc acccaaacag gacaagagca gcctggggcc

1441 aagcagacgg gcaagtggag ccacctcttt cctccctccg cggatgaagc ccagccacat

1501 ttcagccgag gtccaaggca ggaggccatt tacttgagac agattctctc ctttttcctg

1561 tcccccatct tctctgggtc cctctaacat ctcccatggc tctccccgct tctcctggtc

1621 actggagtct cctccccatg tacccaagg

(2) INFORMATION FOR SEQ ID NO: 178: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 703 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 178: ccaccaatct tgggcaagaa gcgagaccat tctccttttt ctctggtcac tcctgtcctt

61 cagggggctc cctctggccc cgactgtcca ttgctgctga agtaatgctg tggcctttct

121 cagtttgggc cccacccaaa accgaagaac ttctccccag aagcttctac ttggttctca

181 gtgttttcac agttatggga acccaagaac agtgtcagac ctaggaggtg ccccactacc

241 accctgtctt tatcaatgtt gtcaccaaag ctgtcacaaa caatggggtg tgggctgtca

301 catggccctg cctaagtaac cacattctcg cttcctcctt ccacacacag ccattggggg

361 ttgctcggat ccgggactgc cgcagggggt gccacagcag tgcctggcag cgtgggctgg

421 gaccttgtca ctaaagcaga gaagccactt cttctgggcc cacgaggcag ctgtcccatg

481 ctctgctgag cacggtggta agtgctggct tgcaaaacca cagggagtgg ctggaggtcc

541 ccatgggcca agggcctgcc ttatagctgc tggcaggccc gggtaggacc gccaggccct

601 tcttgagctg cagcacctgg ggagggcaaa ctgaggctcc tccgactcaa gactaaagtc

661 ttcctggagt ctgtggcctt attctgtgac tcttctgaat cct

(2) INFORMATION FOR SEQ ID NO: 179: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3409 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 179: tagaagaagt taaagggccc tcctggatgg ctttattcat gttgatgagt aataataata

61 actgctactg gctgaggatc ttctccatcc caggcatgtc agggatgcct aagtccccag

121 tccctgctcc agaccagaca tcttccagct gtggcagtag agggtggtgg tctagggtgc

181 ttgctaagcc caagggtgaa actgtcttga catccctccg cccattgtct cctcctaggt

241 gccatgcctc tgcaactcct cctgttgctg atcctactgg gccctggcaa cagcttgcag

301 ctgtgggaca cctgggcaga tgaagccgag aaagccttgg gtcccctgct tgcccgggac

361 cggagacagg ccaccgaata tgagtaccta gattatgatt tcctgccaga aacggagcct

421 ccagaaatgc tgaggaacag cactgacacc actcctctga ctgggcctgg aacccctgag

481 tctaccactg tggagcctgc tgcaaggcgt tctactggcc tggatgcagg aggggcagtc

541 acagagctga ccacggagct ggccaacatg gggaacctgt ccacggattc agcagctatg

601 gagatacaga ccactcaacc agcagccacg gaggcacaga ccactcaacc agtgcccacg

661 gaggcacaga ccactccact ggcagccaca gaggcacaga caactcgact gacggccacg

721 gaggcacaga ccactccact ggcagccaca gaggcacaga ccactccacc agcagccacg

781 gaagcacaga ccactcaacc cacaggcctg gaggcacaga ccactgcacc agcagccatg

841 gaggcacaga ccactgcacc agcagccatg gaagcacaga ccactccacc agcagccatg

901 gaggcacaga ccactcaaac cacagccatg gaggcacaga ccactgcacc agaagccacg

961 gaggcacaga ccactcaacc cacagccacg gaggcacaga ccactccact ggcagccatg

1021 gaggccctgt ccacagaacc cagtgccaca gaggccctgt ccatggaacc tactaccaaa

1081 agaggtctgt tcataccctt ttctgtgtcc tctgttactc acaagggcat tcccatggca

1141 gccagcaatt tgtccgtcaa ctacccagtg ggggccccag accacatctc tgtgaagcag

1201 tgcctgctgg ccatcctaat cttggcgctg gtggccacta tcttcttcgt gtgcactgtg

1261 gtgctggcgg tccgcctctc ccgcaagggc cacatgtacc ccgtgcgtaa ttactccccc

1321 accgagatgg tctgcatctc atccctgttg cctgatgggg gtgaggggcc ctctgccaca

1381 gccaatgggg gcctgtccaa ggccaagagc ccgggcctga cgccagagcc cagggaggac

1441 cgtgaggggg atgacctcac cctgcacagc ttcctccctt agctcactct gccatctgtt

1501 ttggcaagac cccacctcca cgggctctcc tgggccaccc ctgagtgccc agaccccaat

1561 ccacagctct gggcttcctc ggagacccct ggggatgggg atcttcaggg aaggaactct

1621 ggccacccaa acaggacaag agcagcctgg ggccaagcag acgggcaagt ggagccacct

1681 ctttcctccc tccgcggatg aagcccagcc acatttcagc cgaggtccaa ggcaggaggc 1741 catttacttg agacagattc tctccttttt cctgtccccc atcttctctg ggtccctcta

1801 acatctccca tggctctccc cgcttctcct ggtcactgga gtctcctccc catgtaccca

1861 aggaagatgg agctccccca tcccacacgc actgcactgc cattgtcttt tggttgccat

1921 ggtcaccaaa caggaagtgg acattctaag ggaggagtac tgaagagtga cggacttctg

1981 aggctgtttc ctgctgctcc tctgacttgg ggcagcttgg gtcttcttgg gcacctctct

2041 gggaaaaccc agggtgaggt tcagcctgtg agggctggga tgggtttcgt gggcccaaag

2101 ggcagacctt tctttgggac tgtgtggacc aaggagcttc catctagtga caagtgaccc

2161 ccagctatcg cctcttgcct tcccctgtgg ccactttcca gggtggactc tgtcttgttc

2221 actgcagtat cccaactgca ggtccagtgc aggcaataaa tatgtgatgg acaaaacgat

2281 agcggaatcc ttcaaggttt caaggctgtc tccttcaggc agccttcccg gaattctcca

2341 tccctcagtg caggatgggg gctggtcctc agctgtctgc cctcagcccc tggcccccca

2401 ggaagcctct ttcatgggct gttaggttga cttcagtttt gcctcttgga caacaggggg

2461 tcttgtacat ccttgggtga ccaggaaaag ttcaggctat ggggggccaa agggagggct

2521 gccccttccc caccagtgac cactttattc cacttcctcc attacccagt tttggcccac

2581 agagtttggt cccccccaaa cctcggacca atatccctct aaacatcaat ctatcctcct

2641 gttaaagaaa aaaaaaaatg ggactgggag cagtggctca tgcctgtaat cccagcactt

2701 tgggaggccg aggcaggtac atcacctgag gtcaggagtt caagactagc ctggccaaca

2761 tagtgaaacc ctgtctctac taaaaataca aagattagtc aggtgtggtg gcacatgcct

2821 gtagtcccag ctactgggga ggctgaggca ggagaattgc ttgaacccgg gaagcggagg

2881 gaggttgcag tgagctgaga tcacgctact gcactccagc ctgggtgaca gagtaagact

2941 ccgtctcaaa aaaaaaaaaa aagattcaat gacccttgtt aaagcatggt aaggaagact

3001 ttgttcaagg ggagtgggac tctctcaatc actgcaggga ctgcagctat gggattttgc

3061 agtgggggca tttgggctca actatgagta cagcaggggc aagtgggagc tgatagccag

3121 ggaacagggt tggatatctg cagctggaaa attaccaaga ggaaacatca ggggaagggg

3181 aattctggct aaactgactg ctggggatgg gttctcggtc attttctaca ctgacctaac

3241 aggattcata ctggaggcag gccagggtgc tcagacatca ccggggggat ggtggcagat

3301 gaggaacgtg atcagatata ggaggtgatc agatatggga ggtgatcaga tatggagtgg

3361 tggggggagg gttgttgcta agctgactta gcagagttct tgttagaac

(2) INFORMATION FOR SEQ ID NO: 180: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3409 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 180: tagaagaagt taaagggccc tcctggatgg ctttattcat gttgatgagt aataataata

61 actgctactg gctgaggatc ttctccatcc caggcatgtc agggatgcct aagtccccag

121 tccctgctcc agaccagaca tcttccagct gtggcagtag agggtggtgg tctagggtgc

181 ttgctaagcc caagggtgaa actgtcttga catccctccg cccattgtct cctcctaggt

241 gccatgcctc tgcaactcct cctgttgctg atcctactgg gccctggcaa cagcttgcag

301 ctgtgggaca cctgggcaga tgaagccgag aaagccttgg gtcccctgct tgcccgggac

361 cggagacagg ccaccgaata tgagtaccta gattatgatt tcctgccaga aacggagcct

421 ccagaaatgc tgaggaacag cactgacacc actcctctga ctgggcctgg aacccctgag

481 tctaccactg tggagcctgc tgcaaggcgt tctactggcc tggatgcagg aggggcagtc

541 acagagctga ccacggagct ggccaacatg gggaacctgt ccacggattc agcagctatg

601 gagatacaga ccactcaacc agcagccacg gaggcacaga ccactcaacc agtgcccacg

661 gaggcacaga ccactccact ggcagccaca gaggcacaga caactcgact gacggccacg

721 gaggcacaga ccactccact ggcagccaca gaggcacaga ccactccacc agcagccacg

781 gaagcacaga ccactcaacc cacaggcctg gaggcacaga ccactgcacc agcagccatg

841 gaggcacaga ccactgcacc agcagccatg gaagcacaga ccactccacc agcagccatg

901 gaggcacaga ccactcaaac cacagccatg gaggcacaga ccactgcacc agaagccacg

961 gaggcacaga ccactcaacc cacagccacg gaggcacaga ccactccact ggcagccatg

1021 gaggccctgt ccacagaacc cagtgccaca gaggccctgt ccatggaacc tactaccaaa

1081 agaggtctgt tcataccctt ttctgtgtcc tctgttactc acaagggcat tcccatggca

1141 gccagcaatt tgtccgtcaa ctacccagtg ggggccccag accacatctc tgtgaagcag

1201 tgcctgctgg ccatcctaat cttggcgctg gtggccacta tcttcttcgt gtgcactgtg

1261 gtgctggcgg tccgcctctc ccgcaagggc cacatgtacc ccgtgcgtaa ttactccccc

1321 accgagatgg tctgcatctc atccctgttg cctgatgggg gtgaggggcc ctctgccaca

1381 gccaatgggg gcctgtccaa ggccaagagc ccgggcctga cgccagagcc cagggaggac

1441 cgtgaggggg atgacctcac cctgcacagc ttcctccctt agctcactct gccatctgtt

1501 ttggcaagac cccacctcca cgggctctcc tgggccaccc ctgagtgccc agaccccaat

1561 ccacagctct gggcttcctc ggagacccct ggggatgggg atcttcaggg aaggaactct

1621 ggccacccaa acaggacaag agcagcctgg ggccaagcag acgggcaagt ggagccacct

1681 ctttcctccc tccgcggatg aagcccagcc acatttcagc cgaggtccaa ggcaggaggc

1741 catttacttg agacagattc tctccttttt cctgtccccc atcttctctg ggtccctcta

1801 acatctccca tggctctccc cgcttctcct ggtcactgga gtctcctccc catgtaccca

1861 aggaagatgg agctccccca tcccacacgc actgcactgc cattgtcttt tggttgccat

1921 ggtcaccaaa caggaagtgg acattctaag ggaggagtac tgaagagtga cggacttctg

1981 aggctgtttc ctgctgctcc tctgacttgg ggcagcttgg gtcttcttgg gcacctctct

2041 gggaaaaccc agggtgaggt tcagcctgtg agggctggga tgggtttcgt gggcccaaag 2101 ggcagacctt tctttgggac tgtgtggacc aaggagcttc catctagtga caagtgaccc

2161 ccagctatcg cctcttgcct tcccctgtgg ccactttcca gggtggactc tgtcttgttc

2221 actgcagtat cccaactgca ggtccagtgc aggcaataaa tatgtgatgg acaaaacgat

2281 agcggaatcc ttcaaggttt caaggctgtc tccttcaggc agccttcccg gaattctcca

2341 tccctcagtg caggatgggg gctggtcctc agctgtctgc cctcagcccc tggcccccca

2401 ggaagcctct ttcatgggct gttaggttga cttcagtttt gcctcttgga caacaggggg

2461 tcttgtacat ccttgggtga ccaggaaaag ttcaggctat ggggggccaa agggagggct

2521 gccccttccc caccagtgac cactttattc cacttcctcc attacccagt tttggcccac

2581 agagtttggt cccccccaaa cctcggacca atatccctct aaacatcaat ctatcctcct

2641 gttaaagaaa aaaaaaaatg ggactgggag cagtggctca tgcctgtaat cccagcactt

2701 tgggaggccg aggcaggtac atcacctgag gtcaggagtt caagactagc ctggccaaca

2761 tagtgaaacc ctgtctctac taaaaataca aagattagtc aggtgtggtg gcacatgcct

2821 gtagtcccag ctactgggga ggctgaggca ggagaattgc ttgaacccgg gaagcggagg

2881 gaggttgcag tgagctgaga tcacgctact gcactccagc ctgggtgaca gagtaagact

2941 ccgtctcaaa aaaaaaaaaa aagattcaat gacccttgtt aaagcatggt aaggaagact

3001 ttgttcaagg ggagtgggac tctctcaatc actgcaggga ctgcagctat gggattttgc

3061 agtgggggca tttgggctca actatgagta cagcaggggc aagtgggagc tgatagccag

3121 ggaacagggt tggatatctg cagctggaaa attaccaaga ggaaacatca ggggaagggg

3181 aattctggct aaactgactg ctggggatgg gttctcggtc attttctaca ctgacctaac

3241 aggattcata ctggaggcag gccagggtgc tcagacatca ccggggggat ggtggcagat

3301 gaggaacgtg atcagatata ggaggtgatc agatatggga ggtgatcaga tatggagtgg 3361 tggggggagg gttgttgcta agctgactta gcagagttct tgttagaac

(2) INFORMATION FOR SEQ ID NO: 181:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 9170 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 181: gccacttctt ctgggcccac gaggcagctg tcccatgctc tgctgagcac ggtggtgcca

61 tgcctctgca actcctcctg ttgctgatcc tactgggccc tggcaacagc ttgcagctgt

121 gggacacctg ggcagatgaa gccgagaaag ccttgggtcc cctgcttgcc cgggaccgga

181 gacaggccac cgaatatgag tacctagatt atgatttcct gccagaaacg gagcctccag

241 aaatgctgag gaacagcact gacaccactc ctctgactgg gcctggaacc cctgagtcta

301 ccactgtgga gcctgctgca aggcgttcta ctggcctgga tgcaggaggg gcagtcacag

361 agctgaccac ggagctggcc aacatgggga acctgtccac ggattcagca gctatggaga

421 tacagaccac tcaaccagca gccacggagg cacagaccac tccactggca gccacagagg

481 cacagacaac tcgactgacg gccacggagg cacagaccac tccactggca gccacagagg

541 cacagaccac tccaccagca gccacggaag cacagaccac tcaacccaca ggcctggagg

601 cacagaccac tgcaccagca gccatggagg cacagaccac tgcaccagca gccatggaag

661 cacagaccac tccaccagca gccatggagg cacagaccac tcaaaccaca gccatggagg

721 cacagaccac tgcaccagaa gccacggagg cacagaccac tcaacccaca gccacggagg

781 cacagaccac tccactggca gccatggagg ccctgtccac agaacccagt gccacagagg

841 ccctgtccat ggaacctact accaaaagag gtctgttcat acccttttct gtgtcctctg

901 ttactcacaa gggcattccc atggcagcca gcaatttgtc cgtcaactac ccagtggggg

961 ccccagacca catctctgtg aagcagtgcc tgctggccat cctaatcttg gcgctggtgg

1021 ccactatctt cttcgtgtgc actgtggtgc tggcggtccg cctctcccgc aagggccaca

1081 tgtaccccgt gcgtaattac tcccccaccg agatggtctg catctcatcc ctgttgcctg

1141 atgggggtga ggggccctct gccacagcca atgggggcct gtccaaggcc aagagcccgg

1201 gcctgacgcc agagcccagg gaggaccgtg agggggatga cctcaccctg cacagcttcc

1261 tcccttagct cactctgcca tctgttttgg caagacccca cctccacggg ctctcctggg

1321 ccacccctga gtgcccagac cccaatccac agctctgggc ttcctcggag acccctgggg

1381 atggggatct tcagggaagg aactctggcc acccaaacag gacaagagca gcctggggcc

1441 aagcagacgg gcaagtggag ccacctcttt cctccctccg cggatgaagc ccagccacat

1501 ttcagccgag gtccaaggca ggaggccatt tacttgagac agattctctc ctttttcctg

1561 tcccccatct tctctgggtc cctctaacat ctcccatggc tctccccgct tctcctggtc

1621 actggagtct cctccccatg tacccaagg

1 ccaccaatct tgggcaagaa gcgagaccat tctccttttt ctctggtcac tcctgtcctt

61 cagggggctc cctctggccc cgactgtcca ttgctgctga agtaatgctg tggcctttct

121 cagtttgggc cccacccaaa accgaagaac ttctccccag aagcttctac ttggttctca

181 gtgttttcac agttatggga acccaagaac agtgtcagac ctaggaggtg ccccactacc

241 accctgtctt tatcaatgtt gtcaccaaag ctgtcacaaa caatggggtg tgggctgtca

301 catggccctg cctaagtaac cacattctcg cttcctcctt ccacacacag ccattggggg

361 ttgctcggat ccgggactgc cgcagggggt gccacagcag tgcctggcag cgtgggctgg

421 gaccttgtca ctaaagcaga gaagccactt cttctgggcc cacgaggcag ctgtcccatg

481 ctctgctgag cacggtggta agtgctggct tgcaaaacca cagggagtgg ctggaggtcc

541 ccatgggcca agggcctgcc ttatagctgc tggcaggccc gggtaggacc gccaggccct

601 tcttgagctg cagcacctgg ggagggcaaa ctgaggctcc tccgactcaa gactaaagtc

661 ttcctggagt ctgtggcctt attctgtgac tcttctgaat cct 1 tagaagaagt taaagggccc tcctggatgg ctttattcat gttgatgagt aataataata

61 actgctactg gctgaggatc ttctccatcc caggcatgtc agggatgcct aagtccccag

121 tccctgctcc agaccagaca tcttccagct gtggcagtag agggtggtgg tctagggtgc 181 ttgctaagcc caagggtgaa actgtcttga catccctccg cccattgtct cctcctaggt

241 gccatgcctc tgcaactcct cctgttgctg atcctactgg gccctggcaa cagcttgcag

301 ctgtgggaca cctgggcaga tgaagccgag aaagccttgg gtcccctgct tgcccgggac

361 cggagacagg ccaccgaata tgagtaccta gattatgatt tcctgccaga aacggagcct

421 ccagaaatgc tgaggaacag cactgacacc actcctctga ctgggcctgg aacccctgag

481 tctaccactg tggagcctgc tgcaaggcgt tctactggcc tggatgcagg aggggcagtc

541 acagagctga ccacggagct ggccaacatg gggaacctgt ccacggattc agcagctatg

601 gagatacaga ccactcaacc agcagccacg gaggcacaga ccactcaacc agtgcccacg

661 gaggcacaga ccactccact ggcagccaca gaggcacaga caactcgact gacggccacg

721 gaggcacaga ccactccact ggcagccaca gaggcacaga ccactccacc agcagccacg

781 gaagcacaga ccactcaacc cacaggcctg gaggcacaga ccactgcacc agcagccatg

841 gaggcacaga ccactgcacc agcagccatg gaagcacaga ccactccacc agcagccatg

901 gaggcacaga ccactcaaac cacagccatg gaggcacaga ccactgcacc agaagccacg

961 gaggcacaga ccactcaacc cacagccacg gaggcacaga ccactccact ggcagccatg

1021 gaggccctgt ccacagaacc cagtgccaca gaggccctgt ccatggaacc tactaccaaa

1081 agaggtctgt tcataccctt ttctgtgtcc tctgttactc acaagggcat tcccatggca

1141 gccagcaatt tgtccgtcaa ctacccagtg ggggccccag accacatctc tgtgaagcag

1201 tgcctgctgg ccatcctaat cttggcgctg gtggccacta tcttcttcgt gtgcactgtg

1261 gtgctggcgg tccgcctctc ccgcaagggc cacatgtacc ccgtgcgtaa ttactccccc

1321 accgagatgg tctgcatctc atccctgttg cctgatgggg gtgaggggcc ctctgccaca

1381 gccaatgggg gcctgtccaa ggccaagagc ccgggcctga cgccagagcc cagggaggac

1441 cgtgaggggg atgacctcac cctgcacagc ttcctccctt agctcactct gccatctgtt

1501 ttggcaagac cccacctcca cgggctctcc tgggccaccc ctgagtgccc agaccccaat

1561 ccacagctct gggcttcctc ggagacccct ggggatgggg atcttcaggg aaggaactct

1621 ggccacccaa acaggacaag agcagcctgg ggccaagcag acgggcaagt ggagccacct

1681 ctttcctccc tccgcggatg aagcccagcc acatttcagc cgaggtccaa ggcaggaggc

1741 catttacttg agacagattc tctccttttt cctgtccccc atcttctctg ggtccctcta

1801 acatctccca tggctctccc cgcttctcct ggtcactgga gtctcctccc catgtaccca

1861 aggaagatgg agctccccca tcccacacgc actgcactgc cattgtcttt tggttgccat

1921 ggtcaccaaa caggaagtgg acattctaag ggaggagtac tgaagagtga cggacttctg

1981 aggctgtttc ctgctgctcc tctgacttgg ggcagcttgg gtcttcttgg gcacctctct

2041 gggaaaaccc agggtgaggt tcagcctgtg agggctggga tgggtttcgt gggcccaaag

2101 ggcagacctt tctttgggac tgtgtggacc aaggagcttc catctagtga caagtgaccc

2161 ccagctatcg cctcttgcct tcccctgtgg ccactttcca gggtggactc tgtcttgttc

2221 actgcagtat cccaactgca ggtccagtgc aggcaataaa tatgtgatgg acaaaacgat

2281 agcggaatcc ttcaaggttt caaggctgtc tccttcaggc agccttcccg gaattctcca

2341 tccctcagtg caggatgggg gctggtcctc agctgtctgc cctcagcccc tggcccccca

2401 ggaagcctct ttcatgggct gttaggttga cttcagtttt gcctcttgga caacaggggg

2461 tcttgtacat ccttgggtga ccaggaaaag ttcaggctat ggggggccaa agggagggct

2521 gccccttccc caccagtgac cactttattc cacttcctcc attacccagt tttggcccac

2581 agagtttggt cccccccaaa cctcggacca atatccctct aaacatcaat ctatcctcct

2641 gttaaagaaa aaaaaaaatg ggactgggag cagtggctca tgcctgtaat cccagcactt

2701 tgggaggccg aggcaggtac atcacctgag gtcaggagtt caagactagc ctggccaaca

2761 tagtgaaacc ctgtctctac taaaaataca aagattagtc aggtgtggtg gcacatgcct

2821 gtagtcccag ctactgggga ggctgaggca ggagaattgc ttgaacccgg gaagcggagg

2881 gaggttgcag tgagctgaga tcacgctact gcactccagc ctgggtgaca gagtaagact

2941 ccgtctcaaa aaaaaaaaaa aagattcaat gacccttgtt aaagcatggt aaggaagact

3001 ttgttcaagg ggagtgggac tctctcaatc actgcaggga ctgcagctat gggattttgc

3061 agtgggggca tttgggctca actatgagta cagcaggggc aagtgggagc tgatagccag

3121 ggaacagggt tggatatctg cagctggaaa attaccaaga ggaaacatca ggggaagggg

3181 aattctggct aaactgactg ctggggatgg gttctcggtc attttctaca ctgacctaac

3241 aggattcata ctggaggcag gccagggtgc tcagacatca ccggggggat ggtggcagat

3301 gaggaacgtg atcagatata ggaggtgatc agatatggga ggtgatcaga tatggagtgg

3361 tggggggagg gttgttgcta agctgactta gcagagttct tgttagaac tagaagaagt taaagggccc tcctggatgg ctttattcat gttgatgagt aataataata

61 actgctactg gctgaggatc ttctccatcc caggcatgtc agggatgcct aagtccccag

121 tccctgctcc agaccagaca tcttccagct gtggcagtag agggtggtgg tctagggtgc

181 ttgctaagcc caagggtgaa actgtcttga catccctccg cccattgtct cctcctaggt

241 gccatgcctc tgcaactcct cctgttgctg atcctactgg gccctggcaa cagcttgcag

301 ctgtgggaca cctgggcaga tgaagccgag aaagccttgg gtcccctgct tgcccgggac

361 cggagacagg ccaccgaata tgagtaccta gattatgatt tcctgccaga aacggagcct

421 ccagaaatgc tgaggaacag cactgacacc actcctctga ctgggcctgg aacccctgag

481 tctaccactg tggagcctgc tgcaaggcgt tctactggcc tggatgcagg aggggcagtc

541 acagagctga ccacggagct ggccaacatg gggaacctgt ccacggattc agcagctatg

601 gagatacaga ccactcaacc agcagccacg gaggcacaga ccactcaacc agtgcccacg

661 gaggcacaga ccactccact ggcagccaca gaggcacaga caactcgact gacggccacg

721 gaggcacaga ccactccact ggcagccaca gaggcacaga ccactccacc agcagccacg

781 gaagcacaga ccactcaacc cacaggcctg gaggcacaga ccactgcacc agcagccatg

841 gaggcacaga ccactgcacc agcagccatg gaagcacaga ccactccacc agcagccatg

901 gaggcacaga ccactcaaac cacagccatg gaggcacaga ccactgcacc agaagccacg

961 gaggcacaga ccactcaacc cacagccacg gaggcacaga ccactccact ggcagccatg

1021 gaggccctgt ccacagaacc cagtgccaca gaggccctgt ccatggaacc tactaccaaa

1081 agaggtctgt tcataccctt ttctgtgtcc tctgttactc acaagggcat tcccatggca

1141 gccagcaatt tgtccgtcaa ctacccagtg ggggccccag accacatctc tgtgaagcag

1201 tgcctgctgg ccatcctaat cttggcgctg gtggccacta tcttcttcgt gtgcactgtg 1261 gtgctggcgg tccgcctctc ccgcaagggc cacatgtacc ccgtgcgtaa ttactccccc 1321 accgagatgg tctgcatctc atccctgttg cctgatgggg gtgaggggcc ctctgccaca 1381 gccaatgggg gcctgtccaa ggccaagagc ccgggcctga cgccagagcc cagggaggac 1441 cgtgaggggg atgacctcac cctgcacagc ttcctccctt agctcactct gccatctgtt 1501 ttggcaagac cccacctcca cgggctctcc tgggccaccc ctgagtgccc agaccccaat 1561 ccacagctct gggcttcctc ggagacccct ggggatgggg atcttcaggg aaggaactct 1621 ggccacccaa acaggacaag agcagcctgg ggccaagcag acgggcaagt ggagccacct 1681 ctttcctccc tccgcggatg aagcccagcc acatttcagc cgaggtccaa ggcaggaggc 1741 catttacttg agacagattc tctccttttt cctgtccccc atcttctctg ggtccctcta 1801 acatctccca tggctctccc cgcttctcct ggtcactgga gtctcctccc catgtaccca 1861 aggaagatgg agctccccca tcccacacgc actgcactgc cattgtcttt tggttgccat 1921 ggtcaccaaa caggaagtgg acattctaag ggaggagtac tgaagagtga cggacttctg 1981 aggctgtttc ctgctgctcc tctgacttgg ggcagcttgg gtcttcttgg gcacctctct 2041 gggaaaaccc agggtgaggt tcagcctgtg agggctggga tgggtttcgt gggcccaaag 2101 ggcagacctt tctttgggac tgtgtggacc aaggagcttc catctagtga caagtgaccc 2161 ccagctatcg cctcttgcct tcccctgtgg ccactttcca gggtggactc tgtcttgttc 2221 actgcagtat cccaactgca ggtccagtgc aggcaataaa tatgtgatgg acaaaacgat 2281 agcggaatcc ttcaaggttt caaggctgtc tccttcaggc agccttcccg gaattctcca 2341 tccctcagtg caggatgggg gctggtcctc agctgtctgc cctcagcccc tggcccccca 2401 ggaagcctct ttcatgggct gttaggttga cttcagtttt gcctcttgga caacaggggg 2461 tcttgtacat ccttgggtga ccaggaaaag ttcaggctat ggggggccaa agggagggct 2521 gccccttccc caccagtgac cactttattc cacttcctcc attacccagt tttggcccac 2581 agagtttggt cccccccaaa cctcggacca atatccctct aaacatcaat ctatcctcct 2641 gttaaagaaa aaaaaaaatg ggactgggag cagtggctca tgcctgtaat cccagcactt 2701 tgggaggccg aggcaggtac atcacctgag gtcaggagtt caagactagc ctggccaaca 2761 tagtgaaacc ctgtctctac taaaaataca aagattagtc aggtgtggtg gcacatgcct 2821 gtagtcccag ctactgggga ggctgaggca ggagaattgc ttgaacccgg gaagcggagg 2881 gaggttgcag tgagctgaga tcacgctact gcactccagc ctgggtgaca gagtaagact 2941 ccgtctcaaa aaaaaaaaaa aagattcaat gacccttgtt aaagcatggt aaggaagact 3001 ttgttcaagg ggagtgggac tctctcaatc actgcaggga ctgcagctat gggattttgc 3061 agtgggggca tttgggctca actatgagta cagcaggggc aagtgggagc tgatagccag 3121 ggaacagggt tggatatctg cagctggaaa attaccaaga ggaaacatca ggggaagggg 3181 aattctggct aaactgactg ctggggatgg gttctcggtc attttctaca ctgacctaac 3241 aggattcata ctggaggcag gccagggtgc tcagacatca ccggggggat ggtggcagat 3301 gaggaacgtg atcagatata ggaggtgatc agatatggga ggtgatcaga tatggagtgg 3361 tggggggagg gttgttgcta agctgactta gcagagttct tgttagaac

(2) INFORMATION FOR SEQ ID NO: 182: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1830 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 182: cctgcctgca cggcacagga gagcaaactt ctacagacag accaaggctt ccatttgctg

61 ctgacacatg gaactgaggt gaaattgtgc tccatgattt tacagatttc ataacgttta

121 agagacggga ctcaggtcat caaaatgaaa gccctcatct ttgcagctgc tggcctcctg

181 cttctgttgc ccactttttg tcagagtggc atggaaaatg atacaaacaa cttggcaaag

241 ccaaccttac ccattaagac ctttcgtgga gctcccccaa attcttttga agagttcccc

301 ttttctgcct tggaaggctg gacaggagcc acgattactg taaaaattaa gtgccctgaa

361 gaaagtgctt cacatctcca tgtgaaaaat gctaccatgg ggtacctgac cagctcctta

421 agtactaaac tgatacctgc catctacctc ctggtgtttg tagttggtgt cccggccaat

481 gctgtgaccc tgtggatgct tttcttcagg accagatcca tctgtaccac tgtattctac

541 accaacctgg ccattgcaga ttttcttttt tgtgttacat tgccctttaa gatagcttat

601 catctcaatg ggaacaactg ggtatttgga gaggtcctgt gccgggccac cacagtcatc

661 ttctatggca acatgtactg ctccattctg ctccttgcct gcatcagcat caaccgctac

721 ctggccatcg tccatccttt cacctaccgg ggcctgccca agcacaccta tgccttggta

781 acatgtggac tggtgtgggc aacagttttc ttatatatgc tgccattttt catactgaag

841 caggaatatt atcttgttca gccagacatc accacctgcc atgatgttca caacacttgc

901 gagtcctcat ctcccttcca actctattac ttcatctcct tggcattctt tggattctta

961 attccatttg tgcttatcat ctactgctat gcagccatca tccggacact taatgcatac

1021 gatcatagat ggttgtggta tgttaaggcg agtctcctca tccttgtgat ttttaccatt

1081 tgctttgctc caagcaatat tattcttatt attcaccatg ctaactacta ctacaacaac

1141 actgatggct tatattttat atatctcata gctttgtgcc tgggtagtct taatagttgc

1201 ttagatccat tcctttattt tctcatgtca aaaaccagaa atcactccac tgcttacctt

1261 acaaaatagt gaaatgatct tagagaacaa ggacagccat cacagagaac gtctgttttc

1321 aagaacaaca taagcatagt gcaaggagct ccatttccga gctcctaaga aatatgcttc

1381 aaaggtcaaa cattacaaaa gcattagtag tttgtttgtt tgtttttgag actgagtctc

1441 actttatcac ccagactggc gtgcagtggc actatcttgg ctcattgcaa cctctgcctc

1501 ccaggtcagc ctcccaagta gctgggatta caccaccatg cccagctact aaaaatactt

1561 gtatttttag tagagacggg gtttcaccat gttgaccagg ctggtcttga actcctgacc

1621 tcaagtgatc ttccggcctc agcctcccaa agtgctggat tacaggcgtg agccactgag

1681 ccagccagca ttagtaattt ttaaaaacac tttatcagta ttttaaaaat gttaatgcag

1741 gagaaaagat atcacaactc tatggaaaat αacatttcca tttgccttat tgctacttca

1801 agctctttaa atcaccatct tccctatttc (2) INFORMATION FOR SEQ ID NO: 183: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1534 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 183: 1 tcatgtgggg gcgactgctc ctgtggcccc tggtgctggg gttcagcctg tctggcggca

61 cccagacccc cagcgtctac gacgagagcg ggagcaccgg aggtggtgat gacagcacgc

121 cctcaatcct gcctgccccc cgcggctacc caggccaagt ctgtgccaat gacagtgaca

181 ccctggagct cccggacagc tcacgggcac tgcttctggg ctgggtgccc accaggctgg

241 tgcccgccct ctatgggctg gtcctggtgg tggggctgcc ggccaatggg ctggcgctgt

301 gggtgctggc cacgcaggca cctcggctgc cctccaccat gctgctgatg aacctcgcga

361 ctgctgacct cctgctggcc ctggcgctgc ccccgcggat cgcctaccac ctgcgtggcc

421 agcgctggcc cttcggggag gccgcctgcc gcctggccac ggccgcactc tatggtcaca

481 tgtatggctc agtgctgctg ctggccgccg tcagcctgga tcgctacctg gccctggtgc

541 acccgctgcg ggcccgcgcc ctgcgtggcc ggcgcctggc ccttggactc tgcatggctg

601 cttggctcat ggcggccgcc ctggcactgc ccctgacact gcagcggcag accttccggc

661 tggcgcgctc cgatcgcgtg ctctgccatg acgcgctgcc cctggacgca caggcctccc

721 actggcaacc ggccttcacc tgcctggcgc tgttgggctg tttcctgccc ctgctggcca

781 tgctgctgtg ctacggggcc accctgcaca cgctggcggc cagcggccgg cgctacggcc

841 acgcgctgag gctgaccgca gtggtgctgg cctccgccgt ggccttcttc gtgcccagca

901 acctgctgct gctgctgcat tactcggacc cgagccccag cgcctggggc aacctctatg

961 gtgcctacgt gcccagcctg gcgctgagca ccctcaacag ctgcgtggat cccttcatct

1021 actactacgt gtcggccgag ttcagggaca aggtgcgggc agggctcttc caacggtcgc

1081 cgggggacac cgtggcctcc aaggcctctg cggaaggggg cagccggggc atgggcaccc

1141 actcctcttt gctccagtga cacaaagtgg ggaaggctgt actgggtcga acagggtccc

1201 ttcccccact tcacgtcctt cctgggacct cagaatgtga ccttatttgg aaatagggtt

1261 gttacaactg tcactagcag aggtcacttt ggagaagggt gggccttaca tccagtgtgg

1321 gtggtgtcct cataagataa ggagaggcca ggcctggtgg ctcacgcctg taatcccagc

1381 actttaagag gccaaggcgg atggatcact tgagcccagg agttcaacac cagcctgagc

1441 aacatggtaa aaccccatct ctaccaaaaa tacaaaaatt agctgggctt ggtggctggc

1501 gcctgtaatc ccagctactc angagactga ggca

(2) INFORMATION FOR SEQ ID NO: 184: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3472 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 184: cgcacccggg

301 cccgcaggcc agaatcaaaa gcaacaaatg ccaccttaga tccccggtca tttcttctca

361 ggaaccccaa tgataaatat gaaccatttt gggaggatga ggagaaaaat gaaagtgggt

421 taactgaata cagattagtc tccatcaata aaagcagtcc tcttcaaaaa caacttcctg

481 cattcatctc agaagatgcc tccggatatt tgaccagctc ctggctgaca ctctttgtcc

541 catctgtgta caccggagtg tttgtagtca gcctcccact aaacatcatg gccatcgttg

601 tgttcatcct gaaaatgaag gtcaagaagc cggcggtggt gtacatgctg cacctggcca

661 cggcagatgt gctgtttgtg tctgtgctcc cctttaagat cagctattac ttttccggca

721 gtgattggca gtttgggtct gaattgtgtc gcttcgtcac tgcagcattt tactgtaaca

781 tgtacgcctc tatcttgctc atgacagtca taagcattga ccggtttctg gctgtggtgt

841 atcccatgca gtccctctcc tggcgtactc tgggaagggc ttccttcact tgtctggcca

901 tctgggcttt ggccatcgca ggggtagtgc ctctcgtcct caaggagcaa accatccagg

961 tgcccgggct caacatcact acctgtcatg atgtgctcaa tgaaaccctg ctcgaaggct

1021 actatgccta ctacttctca gccttctctg ctgtcttctt ttttgtgccg ctgatcattt

1081 ccacggtctg ttatgtgtct atcattcgat gtcttagctc ttccgcagtt gccaaccgca

1141 gcaagaagtc ccgggctttg ttcctgtcag ctgctgtttt ctgcatcttc atcatttgct

1201 tcggacccac aaacgtcctc ctgattgcgc attactcatt cctttctcac acttccacca

1261 cagaggctgc ctactttgcc tacctcctct gtgtctgtgt cagcagcata agctcgtgca

1321 tcgaccccct aatttactat tacgcttcct ctgagtgcca gaggtacgtc tacagtatct

1381 tatgctgcaa agaaagttcc gatcccagca gttataacag cagtgggcag ttgatggcaa

1441 gtaaaatgga tacctgctct agtaacctga ataacagcat atacaaaaag ctgttaactt

1501 aggaaaaggg actgctggga ggttaaaaag aaaagtttat aaaagtgaat aacctgagga

1561 ttctattagt ccccacccaa actttattga ttcacctcct aaaacaacag atgtacgact

1621 tgcatacctg ctttttatgg gagctgtcaa gcatgtattt ttgtcaatta ccagaaagat

1681 aacaggacga gatgacggtg ttattccaag ggaatattgc caatgctaca gtaataaatg

1741 aatgtcactt ctggatatag ctaggtgaca tatacatact tacatgtgtg tatatgtaga

1801 tgtatgcaca cacatatatt atttgcagtg cagtatagaa taggcacttt aaaacactct

1861 ttccccgcac cccagcaatt atgaaaataa tctctgattc cctgatttaa tatgcaaagt

1921 ctaggttggt agagtttagc cctgaacatt tcatggtgtt catcaacagt gagagactcc

1981 atagtttggg cttgtaccac ttttgcaaat aagtgtattt tgaaattgtt tgacggcaag 2041 gtttaagtta ttaagaggta agacttagta ctatctgtgc gtagaagttc tagtgttttc

2101 aattttaaac atatccaagt ttgaattcct aaaattatgg aaacagatga aaagcctctg

2161 ttttgatatg ggtagtattt tttacatttt acacactgta cacataagcc aaaactgagc

2221 ataagtcctc tagtgaatgt aggctggctt tcagagtagg ctattcctga gagctgcatg

2281 tgtccgcccc cgatggagga ctccaggcag cagacacatg ccagggccat gtcagacaca

2341 gattggccag aaaccttcct gctgagcctc acagcagtga gactggggcc actacatttg

2401 ctccatcctc ctgggattgg ctgtgaactg atcatgttta tgagaaactg gcaaagcaga

2461 atgtgatatc ctaggaggta atgaccatga aagacttctc tacccatctt aaaaacaacg

2521 aaagaaggca tggacttctg gatgcccatc cactgggtgt aaacacatct agtagttgtt

2581 ctgaaatgtc agttctgata tggaagcacc cattatgcgc tgtggccact ccaataggtg

2641 ctgagtgtac agagtggaat aagacagaga cctgccctca agagcaaagt agatcatgca

2701 tagagtgtga tgtatgtgta ataaatatgt ttcacacaaa caaggcctgt cagctaaaga

2761 agtttgaaca tttgggttac tatttcttgt ggttataact taatgaaaac aatgcagtac

2821 aggacatata ttttttaaaa taagtctgat ttaattgggc actatttatt tacaaatgtt

2881 ttgctcaata gattgctcaa atcaggtttt cttttaagaa tcaatcatgt cagtctgctt

2941 agaaataaca gaagaaaata gaattgacat tgaaatctag gaaaattatt ctataatttc

3001 catttactta agacttaatg agactttaaa agcatttttt aacctcctaa gtatcaagta

3061 tagaaaatct tcatggaatt cacaaagtaa tttggaaatt aggttgaaac atatctctta

3121 tcttacgaaa aaatggtagc attttaaaca aaatagaaag ttgcaaggca aatgtttatt

3181 taaaagagca ggccaggcgc ggtggctcac gcctgtaatc ccagcacttt gggaggctga

3241 ggcgggtgga tcacgaggtc aggagatcga gaccatcctg gctaacacgg tgaaacccgt

3301 ctctactaaa aatgcaaaaa aaattagccg ggcgtggtgg caggcacctg tagtcccagc

3361 tactcgggag gctgaggcag gagactggcg tgaacccagg aggcggacct tgtagtgagc

3421 cgagatcgcg ccactgtgct ccagcctggg caacagagca agactccatc tc

(2) INFORMATION FOR SEQ ID NO: 185: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 6836 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 185: cctgcctgca cggcacagga gagcaaactt ctacagacag accaaggctt ccatttgctg

61 ctgacacatg gaactgaggt gaaattgtgc tccatgattt tacagatttc ataacgttta

121 agagacggga ctcaggtcat caaaatgaaa gccctcatct ttgcagctgc tggcctcctg

181 cttctgttgc ccactttttg tcagagtggc atggaaaatg atacaaacaa cttggcaaag

241 ccaaccttac ccattaagac ctttcgtgga gctcccccaa attcttttga agagttcccc

301 ttttctgcct tggaaggctg gacaggagcc acgattactg taaaaattaa gtgccctgaa

361 gaaagtgctt cacatctcca tgtgaaaaat gctaccatgg ggtacctgac cagctcctta

421 agtactaaac tgatacctgc catctacctc ctggtgtttg tagttggtgt cccggccaat

481 gctgtgaccc tgtggatgct tttcttcagg accagatcca tctgtaccac tgtattctac

541 accaacctgg ccattgcaga ttttcttttt tgtgttacat tgccctttaa gatagcttat

601 catctcaatg ggaacaactg ggtatttgga gaggtcctgt gccgggccac cacagtcatc

661 ttctatggca acatgtactg ctccattctg ctccttgcct gcatcagcat caaccgctac

721 ctggccatcg tccatccttt cacctaccgg ggcctgccca agcacaccta tgccttggta

781 acatgtggac tggtgtgggc aacagttttc ttatatatgc tgccattttt catactgaag

841 caggaatatt atcttgttca gccagacatc accacctgcc atgatgttca caacacttgc

901 gagtcctcat ctcccttcca actctattac ttcatctcct tggcattctt tggattctta

961 attccatttg tgcttatcat ctactgctat gcagccatca tccggacact taatgcatac

1021 gatcatagat ggttgtggta tgttaaggcg agtctcctca tccttgtgat ttttaccatt

1081 tgctttgctc caagcaatat tattcttatt attcaccatg ctaactacta ctacaacaac

1141 actgatggct tatattttat atatctcata gctttgtgcc tgggtagtct taatagttgc

1201 ttagatccat tcctttattt tctcatgtca aaaaccagaa atcactccac tgcttacctt

1261 acaaaatagt gaaatgatct tagagaacaa ggacagccat cacagagaac gtctgttttc

1321 aagaacaaca taagcatagt gcaaggagct ccatttccga gctcctaaga aatatgcttc

1381 aaaggtcaaa cattacaaaa gcattagtag tttgtttgtt tgtttttgag actgagtctc

1441 actttatcac ccagactggc gtgcagtggc actatcttgg ctcattgcaa cctctgcctc

1501 ccaggtcagc ctcccaagta gctgggatta caccaccatg cccagctact aaaaatactt

1561 gtatttttag tagagacggg gtttcaccat gttgaccagg ctggtcttga actcctgacc

1621 tcaagtgatc ttccggcctc agcctcccaa agtgctggat tacaggcgtg agccactgag

1681 ccagccagca ttagtaattt ttaaaaacac tttatcagta ttttaaaaat gttaatgcag

1741 gagaaaagat atcacaactc tatggaaaat gacatttcca tttgccttat tgctacttca

1801 agctctttaa atcaccatct tccctatttc tcatgtgggg gcgactgctc ctgtggcccc tggtgctggg gttcagcctg tctggcggca

61 cccagacccc cagcgtctac gacgagagcg ggagcaccgg aggtggtgat gacagcacgc

121 cctcaatcct gcctgccccc cgcggctacc caggccaagt ctgtgccaat gacagtgaca

181 ccctggagct cccggacagc tcacgggcac tgcttctggg ctgggtgccc accaggctgg

241 tgcccgccct ctatgggctg gtcctggtgg tggggctgcc ggccaatggg ctggcgctgt

301 gggtgctggc cacgcaggca cctcggctgc cctccaccat gctgctgatg aacctcgcga

361 ctgctgacct cctgctggcc ctggcgctgc ccccgcggat cgcctaccac ctgcgtggcc

421 agcgctggcc cttcggggag gccgcctgcc gcctggccac ggccgcactc tatggtcaca 481 tgtatggctc agtgctgctg ctggccgccg tcagcctgga tcgctacctg gccctggtgc

541 acccgctgcg ggcccgcgcc ctgcgtggcc ggcgcctggc ccttggactc tgcatggctg

601 cttggctcat ggcggccgcc ctggcactgc ccctgacact gcagcggcag accttccggc

661 tggcgcgctc cgatcgcgtg ctctgccatg acgcgctgcc cctggacgca caggcctccc

721 actggcaacc ggccttcacc tgcctggcgc tgttgggctg tttcctgccc ctgctggcca

781 tgctgctgtg ctacggggcc accctgcaca cgctggcggc cagcggccgg cgctacggcc

841 acgcgctgag gctgaccgca gtggtgctgg cctccgccgt ggccttcttc gtgcccagca

901 acctgctgct gctgctgcat tactcggacc cgagccccag cgcctggggc aacctctatg

961 gtgcctacgt gcccagcctg gcgctgagca ccctcaacag ctgcgtggat cccttcatct

1021 actactacgt gtcggccgag ttcagggaca aggtgcgggc agggctcttc caacggtcgc

1081 cgggggacac cgtggcctcc aaggcctctg cggaaggggg cagccggggc atgggcaccc

1141 actcctcttt gctccagtga cacaaagtgg ggaaggctgt actgggtcga acagggtccc

1201 ttcccccact tcacgtcctt cctgggacct cagaatgtga ccttatttgg aaatagggtt

1261 gttacaactg tcactagcag aggtcacttt ggagaagggt gggccttaca tccagtgtgg

1321 gtggtgtcct cataagataa ggagaggcca ggcctggtgg ctcacgcctg taatcccagc

1381 actttaagag gccaaggcgg atggatcact tgagcccagg agttcaacac cagcctgagc

1441 aacatggtaa aaccccatct ctaccaaaaa tacaaaaatt agctgggctt ggtggctggc

1501 gcctgtaatc ccagctactc angagactga ggcacgcacc cggg

301 cccgcaggcc agaatcaaaa gcaacaaatg ccaccttaga tccccggtca tttcttctca

361 ggaaccccaa tgataaatat gaaccatttt gggaggatga ggagaaaaat gaaagtgggt

421 taactgaata cagattagtc tccatcaata aaagcagtcc tcttcaaaaa caacttcctg

481 cattcatctc agaagatgcc tccggatatt tgaccagctc ctggctgaca ctctttgtcc

541 catctgtgta caccggagtg tttgtagtca gcctcccact aaacatcatg gccatcgttg

601 tgttcatcct gaaaatgaag gtcaagaagc cggcggtggt gtacatgctg cacctggcca

661 cggcagatgt gctgtttgtg tctgtgctcc cctttaagat cagctattac ttttccggca

721 gtgattggca gtttgggtct gaattgtgtc gcttcgtcac tgcagcattt tactgtaaca

781 tgtacgcctc tatcttgctc atgacagtca taagcattga ccggtttctg gctgtggtgt

841 atcccatgca gtccctctcc tggcgtactc tgggaagggc ttccttcact tgtctggcca

901 tctgggcttt ggccatcgca ggggtagtgc ctctcgtcct caaggagcaa accatccagg

961 tgcccgggct caacatcact acctgtcatg atgtgctcaa tgaaaccctg ctcgaaggct

1021 actatgccta ctacttctca gccttctctg ctgtcttctt ttttgtgccg ctgatcattt

1081 ccacggtctg ttatgtgtct atcattcgat gtcttagctc ttccgcagtt gccaaccgca

1141 gcaagaagtc ccgggctttg ttcctgtcag ctgctgtttt ctgcatcttc atcatttgct

1201 tcggacccac aaacgtcctc ctgattgcgc attactcatt cctttctcac acttccacca

1261 cagaggctgc ctactttgcc tacctcctct gtgtctgtgt cagcagcata agctcgtgca

1321 tcgaccccct aatttactat tacgcttcct ctgagtgcca gaggtacgtc tacagtatct

1381 tatgctgcaa agaaagttcc gatcccagca gttataacag cagtgggcag ttgatggcaa

1441 gtaaaatgga tacctgctct agtaacctga ataacagcat atacaaaaag ctgttaactt

1501 aggaaaaggg actgctggga ggttaaaaag aaaagtttat aaaagtgaat aacctgagga

1561 ttctattagt ccccacccaa actttattga ttcacctcct aaaacaacag atgtacgact

1621 tgcatacctg ctttttatgg gagctgtcaa gcatgtattt ttgtcaatta ccagaaagat

1681 aacaggacga gatgacggtg ttattccaag ggaatattgc caatgctaca gtaataaatg

1741 aatgtcactt ctggatatag ctaggtgaca tatacatact tacatgtgtg tatatgtaga

1801 tgtatgcaca cacatatatt atttgcagtg cagtatagaa taggcacttt aaaacactct

1861 ttccccgcac cccagcaatt atgaaaataa tctctgattc cctgatttaa tatgcaaagt

1921 ctaggttggt agagtttagc cctgaacatt tcatggtgtt catcaacagt gagagactcc

1981 atagtttggg cttgtaccac ttttgcaaat aagtgtattt tgaaattgtt tgacggcaag

2041 gtttaagtta ttaagaggta agacttagta ctatctgtgc gtagaagttc tagtgttttc

2101 aattttaaac atatccaagt ttgaattcct aaaattatgg aaacagatga aaagcctctg

2161 ttttgatatg ggtagtattt tttacatttt acacactgta cacataagcc aaaactgagc

2221 ataagtcctc tagtgaatgt aggctggctt tcagagtagg ctattcctga gagctgcatg

2281 tgtccgcccc cgatggagga ctccaggcag cagacacatg ccagggccat gtcagacaca

2341 gattggccag aaaccttcct gctgagcctc acagcagtga gactggggcc actacatttg

2401 ctccatcctc ctgggattgg ctgtgaactg atcatgttta tgagaaactg gcaaagcaga

2461 atgtgatatc ctaggaggta atgaccatga aagacttctc tacccatctt aaaaacaacg

2521 aaagaaggca tggacttctg gatgcccatc cactgggtgt aaacacatct agtagttgtt

2581 ctgaaatgtc agttctgata tggaagcacc cattatgcgc tgtggccact ccaataggtg

2641 ctgagtgtac agagtggaat aagacagaga cctgccctca agagcaaagt agatcatgca

2701 tagagtgtga tgtatgtgta ataaatatgt ttcacacaaa caaggcctgt cagctaaaga

2761 agtttgaaca tttgggttac tatttcttgt ggttataact taatgaaaac aatgcagtac

2821 aggacatata ttttttaaaa taagtctgat ttaattgggc actatttatt tacaaatgtt

2881 ttgctcaata gattgctcaa atcaggtttt cttttaagaa tcaatcatgt cagtctgctt

2941 agaaataaca gaagaaaata gaattgacat tgaaatctag gaaaattatt ctataatttc

3001 catttactta agacttaatg agactttaaa agcatttttt aacctcctaa gtatcaagta

3061 tagaaaatct tcatggaatt cacaaagtaa tttggaaatt aggttgaaac atatctctta

3121 tcttacgaaa aaatggtagc attttaaaca aaatagaaag ttgcaaggca aatgtttatt

3181 taaaagagca ggccaggcgc ggtggctcac gcctgtaatc ccagcacttt gggaggctga

3241 ggcgggtgga tcacgaggtc aggagatcga gaccatcctg gctaacacgg tgaaacccgt 3301 ctctactaaa aatgcaaaaa aaattagccg ggcgtggtgg caggcacctg tagtcccagc

3361 tactcgggag gctgaggcag gagactggcg tgaacccagg aggcggacct tgtagtgagc

3421 cgagatcgcg ccactgtgct ccagcctggg caacagagca agactccatc tc

6

Claims

WHAT IS CLAIMED AS NOVEL AND UNOBVIOUS IN UNITED STATES LETTERS PATENT IS:

1. A pharmaceutical composition, comprising a nucleic acid which comprises an oligonucleotide (oligo) consisting of up to about 15% adenosine (A), and which is effective for alleviating or .inhibiting bronchoconstriction, allergy(ies) and/or inflammation, the oligo being anti-sense to a target selected from the group consisting of target genes and their corresponding mRNAs; genomic and mRNA flanking regions selected from the group consisting of 3' and 5' intron-exon borders and the juxta-section between coding and non-coding regions; and all mRNA segments encoding polypeptides associated with a disease(s) or condition(s) afflicting lung airways; combinations thereof; pharmaceutically acceptable salts thereof; and mixtures thereof.

2. The composition of claim 1, wherein the oligo consists of up to about 10% A.

3. The composition of claim 2, wherein the oligo consists of up to about 5% A.

4. The composition of claim 3, wherein the oligo consists of up to about 3% A.

5. The composition of claim 4, wherein the oligo is A-free.

6. The composition of claim 1, wherein the target gene is selected from the group consisting of target genes and mRNAs encoding polypeptides selected from the group consisting of transcription factors, stimulating and activating factors, interleukins, interleukin receptors, chemokines, chemokine receptors, endogenously produced specific and non-specific enzymes, immunoglobulins, antibody receptors, central nervous system (CNS) and peripheral nervous and non-nervous system receptors, CNS and peripheral nervous and non- nervous system peptide transmitters, adhesion molecules, defensines, growth factors, vasoactive peptides and receptors, and binding proteins; and target genes and mRNAs corresponding to oncogenes, and flanking regions and intron and exon borders.

7. The agent of claim 6, wherein the encoded polypeptides are selected from the group consisting of Nf B Transcription Factor, Interleukin-8 Receptor (IL-8 R), Interleukin 5 Receptor (IL-5 R), Interleukin 4 Receptor (IL-4 R), Interleukin 3 Receptor (IL-3 R), Interleukin- l╬▓ (IL-l╬▓), Interleukin l╬▓ Receptor (IL- l╬▓ R), Eotaxin, Tryptase, Major Basic Protein, ╬▓2-adrenergic Receptor Kinase, Endothelin Receptor A, Endothelin Receptor B, Preproendothelin, Bradykinin B2 Receptor, IgE High Affinity Receptor, Interleukin 1 (IL-1), Interleukin 1 Receptor (IL-1 R), Interleukin 9 (IL-9), Interleukin-9 Receptor (IL-9 R), Interleukin 11 (IL-11), Interleukin- 11 Receptor (IL-11 R), Inducible Nitric Oxide Synthase, Cyclooxygenase (COX), Intracellular Adhesion Molecule 1 (ICAM-1) Vascular Cellular Adhesion Molecule (VCAM), Rantes, Endothelial Leukocyte Adhesion Molecule (ELAM-1), Monocyte Activating Factor, Neutrophil Chemotactic Factor, Neutrophil Elastase, Defensin 1, 2 and 3, Muscarinic Acetylcholine Receptors, Platelet Activating Factor, Tumor Necrosis Factor ╬▒, 5- lipoxygenase, Phosphodiesterase IV, Substance P, Substance P Receptor, Histamine Receptor, Chymase, CCR-1 CC Chemokine Receptor, CCR-2 CC Chemokine Receptor, CCR-3 CC Chemokine Receptor, CCR-4 CC Chemokine Receptor, CCR-5 CC Chemokine Receptor, Prostanoid Receptors, GATA-3 Transcription Factor, Neutrophil Adherence Receptor, MAP Kinase, Interleukin-9 (IL-9), NFAT Transcription Factors, STAT 4, MIP- l╬▒, MCP-2, MCP-3, MCP-4, Cyclophillins, Phospholipase A2, Basic Fibroblast Growth Factor, Metalloproteinase, CSBP/p38 MAP Kinase, Tryptose Receptor, PDG2, Interleukin-3 (IL-3), Interleukin- l╬▓ (IL-l╬▓), Cyclosporin A- Binding Protein, FK5-Binding Protein, ╬▒4╬▓l Selectin, Fibronectin, ╬▒4╬▓7 Selectin, Mad CAM-1, LFA-1 (CDl la/CD18), PECAM-1, LFA-1 Selectin, C3bi, PSGL-1, E-Selectin, P-Selectin, CD-34, L-Selectin, pl50,95, Mac-1 (CDl lb/CD18), Fucosyl transferase, VLA-4, CD-18/CDl la, CD l ib/CD 18, ICAM2 and ICAM3, C5a, CCR3 (Eotaxin Receptor), CCR1, CCR2, CCR4, CCR5, LTB-4, AP-1 Transcription Factor, Protein kinase C, Cysteinyl Leukotriene Receptor, Tachychinnen Receptors (tach R), I╬║B Kinase 1 & 2, STAT 6, c-mas and NF- Interleukin-6 (NF-IL-6).

8. The composition of claim 1, wherein at least one A is substituted by a universal base selected from the group consisting of heteroaromatic bases which bind to a thymidine base but have antagonist activity and less than about 0.3 of the adenosine base agonist activity at the adenosine A,, A_2b and A₃ receptors, and heteroaromatic bases which have no activity or have an agonist activity at the adenosine A_2a receptor.

9. The composition of claim 8, wherein all As are substituted by universal bases selected from the group consisting of heteroaromatic bases which bind to a thymidine base but have antagonist activity and less than about 0.3 of the adenosine base agonist activity at the adenosine AΓÇ₧ A_2b and A₃ receptors, and heteroaromatic bases which have no activity or have an agonist activity at the adenosine A_2a receptor.

10. The composition of claim 8, wherein the heteroaromatic bases are selected from the group consisting of pyrimidines and purines, which may be substituted by O, halo, NH₂, SH, SO, SO,, S0₃, COOH and branched and fused primary and secondary amino, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkoxy, alkenoxy, acyl, cycloacyl, arylacyl, alkynoxy, cycloalkoxy, aroyl, arylthio, arylsulfoxyl, halocycloalkyl, alkylcycloalkyl, alkenylcycloalkyl, alkynylcycloalkyl, haloaryl, alkylaryl, alkenylaryl, alkynylaryl, arylalkyl, arylalkenyl, arylalkynyl, arylcycloalkyl, which may be further substituted by O, halo, NH₂, primary, secondary and tertiary amine, SH, SO, S0₂, S0₃, cycloalkyl, heterocycloalkyl and heteroaryl.

11. The composition of claim 10, wherein the pyrimidines and purines are substituted at positions 1, 2, 3, 4, 7 and 8.

12. The composition of claim 11, wherein the pyrimidines and purines are selected from the group consisting of theophylline, caffeine, dyphylline, etophylline, acephylline piperazine, bamifylline, enprofylline and xantine having the chemical formula

wherein R¹ and R² are independently ^'. H, alky.l., al.kenyl or alkynyl and R³ is H, aryl, dicycloalkyl, dicycloalkenyl, dicycloalkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, O-cycloalkyl, O-cycloalkenyl, O- cycloalkynyl, NH₂-alkylamino-ketoxyalkyloxy-aryl and mono and dialkylaminoalkyl-N-alkylamino-SO_j aryl.

13. The composition of claim 12, wherein the universal base is selected from the group consisting of 3-nitropyrrole-2'-deoxynucleoside, 5-nitro-indole, 2-deoxyribosyl-(5-nitroindole), 2-deoxyribofuranosyl-(5- nitroindole), 2'-deoxyinosine, 2'-deoxynebularine, 6H, 8H-3,4-dihydropyrimido [4,5-c] oxazine-7-one or 2-amino- 6-methoxyaminopurine. "

14. The composition of claim 1, where a methylated cytocine (^mC) is substituted for at least one CpG dinucleotide if present in the oligo(s).

15. The composition of claim 1, wherein at least one nucleotide linking residue of the anti-sense oligonucleotide(s) is a residue selected from the group consisting of methylphosphonate, phosphotriester, phosphorothioate, phosphorodithioate, boranophosphate, formacetal, thioformacetal, thioether, carbonate, carbamate, sulfate, sulfonate, sulfamate, sulfonamide, sulfone, sulfite, sulfoxide, sulfide, hydroxylamine, memylene(methyimino), methyleneoxy (methylimino), 2'-0-methyl, phosphoramidate residues and combinations thereof.

16. The agent of claim 15, wherein all nucleotide linking residues are selected from the group consisting of methylphosphonate, phosphotriester, phosphorothioate, phosphorodithioate, boranophosphate, formacetal, thioformacetal, thioether, carbonate, carbamate, sulfate, sulfonate, sulfamate, sulfonamide, sulfone, sulfite, sulfoxide, sulfide, hydroxylamine, memylene(memyimino), methyleneoxy (methylimino), 2'-0-methyl, phosphoramidate residues and combinations thereof.

17. The composition of claim 1, wherein the anti-sense oligonucleotide comprises about 7 to 60 mononucleotides.

18. The composition of claim 1, wherein the anti-sense oligonucleotide comprises fragments 1 to 1670 (SEQ ED NOS: 11 through 1680).

19. The composition of claim 1, wherein the anti-sense oligonucleotide is linked to an agent selected from the group consisting of cell internalized or up-taken agent(s) and cell targeting agents.

20. The composition of claim 19, wherein the cell internalized or up taken agent is selected from the group consisting of transferrin, asialoglycoprotein and streptavidin.

21. The composition of claim 19, wherein the nucleic acid is linked to a vector.

22. The vector of claim 21 , which comprises a prokaryotic or eukaryotic vector.

23. The composition of claim 1, wherein the oligo is hybridized to a ribonucleic acid.

24. A cell, comprising the agent of claim 1.

25. The composition of claim 1, further comprising a carrier.

26. The composition of claim 25, wherein the carrier comprises a biologically acceptable carrier.

27. The composition of claim 26, wherein the carrier comprises a pharmaceutically or veterinarily acceptable carrier.

28. The composition of claim 25, wherein the carrier is selected from the group consisting of gaseous, liquid, solid carriers and mixtures thereof.

29. The composition of claim 25, further comprising an agent selected from the group consisting of other therapeutic agents, surfactants, antioxidants, flavoring and coloring agents, fillers, volatile oils, buffering agents, dispersants, RNA inactivating agents, anti-oxidants, flavoring agents, propellants and preservatives.

30. The composition of claim 29, comprising the nucleic acid, a surfactant and a carrier.

31. The composition of claim 29, wherein the surfactant is selected from the group consisting of surfactant protein A, surfactant protein B, surfactant protein C, surfactant protein D and surfactant protein and active fragments thereof, non-dipalmitoyl disaturated phosphatidylcholine, dipalmitoylphosphatidylcholine, phosphatidylcholine, phosphatidylglycerol, phosphatidylinositol, phosphatidylethanolamine, phosphatidylserine, phosphatidic acid, ubiquinones, lysophosphatidylethanolamine, lysophosphatidylcholine, palmitoyl-lysophosphatidylcholin, dehydroepiandrosterone, dolichols, sulfatidic acid, glycerol-3-phosphate, dihydroxyacetone phosphate, glycerol, glycero-3-phosphocholine, dihydroxyacetone, palmitate, cytidine diphosphate (CDP) diacylglycerol, CDP choline, choline, choline phosphate, artificial lamellar bodies vehicles for surfactant components, omega-3 fatty acids, polyenic acid, polyenoic acid, lecithin, palmitic acid, non-ionic ethylene and/or propylene oxide block copolymers, polyoxypropylene, polyoxyethylene, poly (vinyl amine) with dextran and/or alkanoyl side chains, Brij 35, Triton X-100, ALEC, Exosurf, Survant and Atovaquone.

32. The composition of claim 31, wherein the RNA inactivating agent comprises an enzyme, preferably a ribozyme.

33. The composition of claim 1, wherein the anti-sense oligonucleotide is present in an amount of about 0.01 to about 99.99 w/w ofthe composition.

34. The composition of claim 33, wherein the anti-sense oligonucleotide is present in an amount of about 1 to about 40 w/w ofthe composition.

35. The composition of claim 34, wherein the anti-sense oligonucleotide is present in an amount of about 5 to about 20 w/w ofthe composition.

36. A formulation, comprising the composition of claim 25, selected from the group consisting of systemic and topical formulations.

37. The formulation of claim 36, selected from the group consisting of oral, intrabuccal, intrapulmonary, rectal, intrauterine, intratunor, intracranial, nasal, intramuscular, subcutaneous, intravascular, intrathecal, inhalable, transdermal, intradermal, intracavitary, implantable, iontophoretic, ocular, vaginal, intraarticular, otical, intravenous, intramuscular, intraglandular, intraorgan, intralymphatic, implantable, slow release and enteric coating formulations.

38. The formulation of claim 37, which is an oral formulation, wherein the carrier is selected from the group consisting of solid and liquid carriers.

39. The oral formulation of claim 38, wherein the liquid carrier is selected from the group consisting of solutions, suspensions, and oil-in-water and water-in-oil emulsions.

40. The oral formulation of claim 38, which is selected from the group consisting of a powder, dragees, tablets, capsules, sprays, aerosols, solutions, suspensions and emulsions.

41. The formulation of claim 36, which is a topical formulation, wherein the carrier is selected from the group consisting of creams, gels, ointments, sprays, aerosols, patches, solutions, suspensions and emulsions.

42. The formulation of claim 36, which is an injectable formulation, wherein the carrier is selected from the group consisting of aqueous and alcoholic solutions and suspensions, oily solutions and suspensions and oil-in-water and water-in-oil emulsions.

43. The formulation of claim 36, which is a rectal formulation in the form of a suppository.

44. The formulation of claim 36, which is a transdermal formulation, wherein the carrier is selected from the group consisting of aqueous and alcoholic solutions, oily solutions and suspensions and oil-in-water and water-in-oil emulsions.

45. The transdermal formulation of claim 36, which is an iontophoretic transdermal formulation, wherein the carrier is selected from the group consisting of aqueous and alcoholic solutions, oily solutions and suspensions and oil-in-water and water-in-oil emulsions, and wherein the formulation further comprises a transdermal transport promoting agent.

46. An implantable capsule or cartridge, comprising the formulation of claim 44.

47. The formulation of claim 36, wherein the carrier is selected from the group consisting of aqueous and alcoholic solutions and suspensions, oily solutions and suspensions and oil-in-water and water-in-oil emulsions.

48. The formulation of claim 36, wherein the carrier comprises a hydrophobic carrier.

49. The formulation of claim 48, wherein the carrier comprises lipid vesicles or particles.

50. The formulation of claim 49, wherein the vesicles comprise liposomes, and the particles comprise microcrystals.

51. The formulation of claim 50, wherein the vesicles comprise liposomes which comprise the anti- sense oligonucleotide.

52. The formulation of claim 49, wherein the vesicles comprise N-(l-[ 2, 3-dioleoxyloxi] propyl) - N,N,N- trimethyl- ammonium methylsulfate.

53. The formulation of claim 36, comprising a respirable or inhalable formulation.

54. The respirable or inhalable formulation of claim 53, comprising an aerosol.

55. The formulation of claim 36, in single or multiple unit form.

56. The formulation of claim 36, in bulk.

57. A kit, comprising a delivery device; in a separate container, the formulation of claim 36; and instructions for adding a carrier and for use ofthe formulation.

58. The kit of claim 57, wherein the delivery device comprises a nebulizer which delivers single metered doses ofthe formulation.

59. The kit of claim 58, wherein the nebulizer comprises an insufflator; and the composition is provided in a piercable or openable capsule or cartridge.

60. The kit of claim 58, wherein the delivery device comprises a pressurized inhaler; and the composition comprises a suspension, solution or dry formulation ofthe agent.

61. The kit of claim 57, further comprising, in a separate container, an agent selected from the group consisting of other therapeutic agents, surfactants, anti-oxidants, flavoring agents, fillers, volatile oils, dispersants, antioxidants, propellants, preservatives, buffering agents, RNA inactivating, cell-internalized or up-taken agents and coloring agents.

62. The kit of claim 61, comprising, in separate containers, a nucleic acid, a surfactant and a carrier.

63. The kit of claim 61 , wherein the solvent is selected from the group consisting of organic solvents and organic solvents mixed with one or more co-solvents.

64. The kit of claim 57, wherein the composition is provided in a capsule or cartridge.

65. An in vivo method of delivering a nucleic acid comprising an anti-sense oligonucleotide (oligo) to a target polynucleotide associated with a disease(s) or condition(s) afflicting lung airways, comprising administering to a subject the composition of claim 1 comprising an amount of the nucleic acid effective to reach the target polynucleotide.

66. The method of claim 65, wherein the composition is administered into the subject's respiratory system.

67. The method of claim 65, wherein the agent is administered directly into the subject's lung (s).

68. The method of claim 65, wherein the amount ofthe agent is effective to bind to the nucleic acid.

69. The method of claim 65, wherein the agent is effective to reduce the production or availability, or to increase the degradation, of the target mRNA or to reduce the amount of the target polypeptide present in the lungs.

70. The method of claim 65, wherein the agent is administered as a respirable aerosol.

71. The method of claim 65, wherein the disease or condition is associated with obstruction of the subject's airways.

72. The method of claim 71 , wherein the disease or condition is associated with asthma.

73. The method of claim 65, wherein the disease or condition is associated with inflammation.

74. The method of claim 65, wherein the disease or condition is associated with an allergy, and the target is selected from the group consisting of immunoglobulins and antibody receptors, genes and mRNAs encoding them, their genomic and mRNA flanking sequences and exon and intron borders of the gene (s) and mRNA(s).

75. The method of claim 65, wherein the disease or condition is associated with a malignancy or cancer, and the mRNA encodes a target selected from the group consisting of immunoglobulins and antibody receptors, genomic flanking sequences and genes and mRNAs encoding them and oncogenes.

76. The method of claim 65, wherein the composition is administered by a transdermal or systemic route.

77. The method of claim 76, wherein the composition is administered orally, intracavitarily, intranasally, intraanally, intravaginally, intrauterally, intraarticularly, transdermally, intrabucally, intravenously, subcutaneously, intramuscularly, intravascularly, intratumorously, intraglandularly, intraocularly, intracranial, into an organ, intravascularly, intrathecally, intralymphatically, intraotically, by implantation, by inhalation, intradermally, intrapulmonarily, intraotically, by slow release, by sustained release and by a pump.

78. The method of claim 65, wherein the subject is a mammal.

79. The method of claim 78, wherein the mammal is selected from the group consisting of humans and animals.

80. The method of claim 79, wherein the mammal is a human.

81. The method of claim 79, wherein the subject is an animal.

82. The method of claim 65, wherein the anti-sense oligonucleotide is administered in amount of about 0.005 to about 150 mg/kg body weight.

83. The method of claim 82, wherein the anti-sense oligonucleotide is administered in an amount of about 0.01 to about 75 mg/kg body weight.

84. The method of claim 83, wherein the anti-sense oligonucleotide is a╬▒lministered in an amount of about 1 to 50 mg/kg body weight.

85. The method of claim 65, which is a prophylactic method.

86. The method of claim 65, which is a therapeutic method.

87. The method of claim 65, wherein the oligo is obtained by

(a) selecting fragments of a target nucleic acid having at least 4 contiguous nucleic acids selected from the group consisting of G and C;

(b) obtaining a first oligonucleotide 4 to 60 nucleotides long which comprises the selected fragment and has a C and G nucleic acid content of up to and including about 15%; and

(c) obtaining a second oligonucleotide 4 to 60 nucleotides long comprising a sequence which is anti-sense to the selected fragment, the second oligonucleotide having an A base content of up to and including about 15%.

88. The method of claim 61, wherein the oligo consists of up to about 10% A.

89. The method of claim 88, wherein the oligo consists of up to about 5% A.

90. The method of claim 88, wherein the oligo consists of up to about 3% A.

91. The method of claim 92, wherein the oligo is A-free.

92. The method of claim 65, wherein the target is selected from the group consisting of genes and mRNAs encoding polypeptides selected from the group consisting of transcription factors, stimulating and activating factors, interleukins, interleukin receptors, chemokines, chemokine receptors, endogenously produced specific and non-specific enzymes, immunoglobulins, antibody receptors, central nervous system (CNS) and peripheral nervous and non-nervous system receptors, CNS and peripheral nervous and non-nervous system peptide transmitters, adhesion molecules, defensines, growth factors, vasoactive peptides, peptide receptors and binding proteins; and genes and mRNAs corresponding to oncogenes.

93. The method of claim 65, wherein at least one A is substituted by a universal base selected from the group consisting of heteroaromatic bases which bind to a thymidine base but have antagonist activity and less than about 0.3 of the adenosine base agonist activity at the adenosine AΓÇ₧ A_2b and A₃ receptors, and heteroaromatic bases which have no activity or have an agonist activity at the adenosine A_2a receptor.

94. The method of claim 93, wehrein all As are substituted by universal bases selected from the group consisting of heteroaromatic bases which bind to a thymidine base but have antagonist activity and less than about 0.3 ofthe adenosine base agonist activity at the adenosine AΓÇ₧ A_2b and A₃ receptors, and heteroaromatic bases which have no activity or have an agonist activity at the adenosine A_2a receptor.

95. The method of claim 95, wherein the heteroaromatic bases are selected from the group consisting of pyrimidines and purines, which may be substituted by O, halo, NH₂, SH, SO, S0₂, S0₃, COOH and branched and fused primary and secondary amino, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkoxy, alkenoxy, acyl, cycloacyl, arylacyl, alkynoxy, cycloalkoxy, aroyl, arylthio, arylsulfoxyl, halocycloalkyl, alkylcycloalkyl, alkenylcycloalkyl, alkynylcycloalkyl, haloaryl, alkylaryl, alkenylaryl, alkynylaryl, arylalkyl, arylalkenyl, arylalkynyl, arylcycloalkyl, which may be further substituted by O, halo, NH₂, primary, secondary and tertiary amine, SH, SO, S0₂, S0₃, cycloalkyl, heterocycloalkyl and heteroaryl.

96. The method of claim 95, wherein the pyrimidines and purines are substituted at positions 1, 2, 3, 4, 7 and 8.

97. The method of claim 96, wherein the pyrimidines and purines are selected from the group consisting of theophylline, caffeine, dyphylline, etophylline, acephylline piperazine, bamifylline, enprofylline and xantine having the chemical formula

O H

I I I

j ' I I PT

wherein R' and R² are independently H, alkyl, alkenyl or alkynyl and R³ is H, aryl, dicycloalkyl, dicycloalkenyl, dicycloalkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, O-cycloalkyl, O-cycloalkenyl, O- cycloalkynyl, NH₂-alkylamino-ketoxyalkyloxy-aryl and mono and dialkylaminoalkyl-N-alkylamino-S0₂ aryl.

98. The method of claim 97, wherein the universal base is selected from the group consisting of 3- nitropyrrole-2'-deoxynucleoside, 5-nitro-indole, 2-deoxyribosyl-(5-nitroindole), 2-deoxyribofuranosyl-(5- nitroindole), 2'-deoxyinosine, 2'-deoxynebularine, 6H, 8H-3,4-dihydropyrimido [4,5-c] oxazine-7-one or 2-amino- 6-memoxyaminopurine.

99. The method of claim 65, further comprising methylating at least one cytocine (mC) jf a CpG dinocleotide if present in the oligo(s).

100. The method of claim 65, further comprising substituting at least one nucleotide linking residue of the anti-sense oligonucleotide(s) with a residue selected from the group consisting of methylphosphonate, phosphotriester, phosphorothioate, phosphorodithioate, boranophosphate, formacetal, thioformacetal, thioether, carbonate, carbamate, sulfate, sulfonate, sulfamate, sulfonamide, sulfone, sulfite, sulfoxide, sulfide, hydroxylamine, me ylene(methyimino), methyleneoxy (me ylimino), 2'-0-methyl, phosphoramidate residues, and combinations thereof.

101. The method of claim 100, wherein all nucleotide linking residues ofthe oligo are substituted.

102. The method of claim 65, further comprising linking the anti-sense oligonucleotide to an agent selected from the group consisting of cell internalized and up-taken agent(s) and cell targeting agents.

103. The method of claim 102, wherein the cell internalized or up taken agent is selected from the group consisting of transferrin. asialoglycoprotein, and streptavidin.

104. The method of claim 102, wherein the cell targeting agent is a vector.

105. The method of claim 104, wherein the vector to which the agent is operatively linked is a prokaryotic or eukaryotic vector.

106. A method of identifying segments in a target polynucleotide suitable for constructing oligonucleotides which are anti-sense to the target polynucleotide and have an adenosine (A) content of up to and including about 15% of all nucleotides, comprising

(a) selecting fragments of a target polynucleotide acid having at least 4 contiguous nucleic acids selected from the group consisting of G and C; and

(a) obtaining a first oligonucleotide 4 to 60 nucleotides long which comprises the selected fragment and has a C and G content of up to and including about 15%.

107. A method of obtaining oligonucleotides which are anti-sense to a target polynucleotide and have an adenosine content of 0 to up to and including about 15%, comprising conducting the method of claim 106; wherein the first oligonucleotide comprises a sequence which is anti-sense to the selected fragment and has an A content of up to and including about 15%.

108. The method of claim 107, further comprising, when the anti-sense fragment comprises at least one A, substituting at least one A with a universal base selected from the group consisting of heteroaromatic bases which bind to thymidine (T) but have less than about 0.3 of A's adenosine AΓÇ₧ A_2b and A₃ receptor agonist activity; and heteroaromatic bases which have no activity or have adenosine A_2a receptor agonist activity.

109. The method of claim 108, wherein the heteroaromatic bases are selected from the group consisting of pyrimidines and purines, which may be substituted by O, halo, NH₂, SH, SO, S0₂, S0₃, COOH and branched and fused primary and secondary amino, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkoxy, alkenoxy, acyl, cycloacyl, arylacyl, alkynoxy, cycloalkoxy, aroyl, arylthio, arylsulfoxyl, halocycloalkyl, alkylcycloalkyl, alkenylcycloalkyl, alkynylcycloalkyl, haloaryl, alkylaryl, alkenylaryl, alkynylaryl, arylalkyl, arylalkenyl, arylalkynyl, arylcycloalkyl, which may be further substituted by O, halo, NH₂, primary, secondary and tertiary amine, SH, SO, S0₂, S0₃, cycloalkyl, heterocycloalkyl and heteroaryl.

110. The method of claim 109, wherein the pyrimidines and purines are substituted at positions 1, 2, 3, 4, 7 and 8.

111. The method of claim 109, wherein the pyrimidines and purines are selected from the group consisting of theophylline, caffeine, dyphylline, etophylline, acephylline piperazine, bamifylline, enprofylline and xantine having the chemical formula

O H

wherein R¹ and ╬¢ -uc -╬╣.u<- .._, .₁.j .., ╬▒--.^., -m-cnyi ur alkynyl and R³ is H, aryl, dicycloalkyl, dicycloalkenyl, dicycloalkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, O-cycloalkyl, O-cycloalkenyl, O- cycloalkynyl, NH₂-all ylamino-ketoxyalkyloxy-aryl and mono and dialkylammoalkyl-N-alkylamino-S0₂ aryl.

112. The method of claim 108, wherein the universal base is selected from the group consisting of 3- nitropyrrole-2'-deoxynucleoside, 5-nitro-indole, 2-deoxyribosyl-(5-nitroindole), 2-deoxyribofuranosyl-(5- nitroindole), 2'-deόxyinosine, 2'-deoxynebularine, 6H, 8H-3,4-dihydropyrimido [4,5-c] oxazine-7-one or 2-amino- 6-methoxyaminopurine.

113. A method of treating a disease or condition associated with a target selected from- the group consisting of proteins, gene (s) and their corresponding rnRNA(s) encoding the proteins, the genes and mRNA flanking regions and their intron and exon borders, associated with a disease or condition afflicting lung airways, comprising administering to a subject afflicted with the disease or condition the composition of claim 1 comprising an anti-bronchoconstriction, anti-allergic and/or anti-inflammatory effective amount ofthe nucleic acid.

114. The method of claim 113, wehrein the amount of nucleic acid administered is effective to reduce the production or availability, or to increase the degradation, of the mRNA, or to reduce the amount of the polypeptide present in the lungs.

115. The method of claim 113, wherein the nucleic acid is administered directly to the lung (s) of the subject.

116. The method of claim 113, wherein the nucleic acid is administered as a respirable aerosol.

117. The method of claim 113, wherein the disease or condition is a disease or condition afflicting the lung (s).

118. The method of claim.117, wherein the disease or condition is associated with obstruction of the subject's airways.

119. The method of claim 117, wherein the disease or condition is associated with asthma.

120. The method of claim 117, wherein the disease or condition is associated with inflammation.

121. The method of claim 113, wherein the disease or condition is associated with allergy (ies), and the target is selected from the group consisting of immunoglobulins and antibody receptors, gene(s) and corresponding mRNA(s) encoding them, the genes and mRNA flanking regions and intron and exon borders.

122. The method of claim 113, wherein the disease or condition is associated with a malignancy or cancer; and the target is selected from the group consisting of immunoglobulins and antibody receptors, gene(s) and mRNA(s) encoding them, gene(s) and mRNA(s) associated with oncogenes, genomic and mRNA flanking regions and exon and intron borders.

123. The method of claim 113, wherein the composition is administered by a topical or systemic route.

124. The method of claim 123, wherein the composition is administered orally, intracavitarily, intranasally, intraanally, intravaginally, intrauterally, intraarticularly, intraotically, intralymphatically, transdermally, intrabucally, intravenously, subcutaneously, intramuscularly, intrarumorously, intraglandularly, intraocularly, intracranial, into an organ, intravascularly, intrathecally, by implantation, by inhalation, intradermally, intrapulmonarily, into the ear, by slow release, by sustained release and by a pump.

125. The method of claim 124, wherein the subject is a mammal.

126. The method of claim 125, wherein the mammals are selected from the group consisting of humans and animals.

127. The method of claim 113, wherein the anti-sense oligonucleotide is administered in amount of about 0.005 to about 150 mg/kg body weight.

128. The method of claim 127, wherein the anti-sense oligonucleotide is administered in an amount of about 0.01 to about 75 mg/kg body weight.

129. The method of claim 130, wherein the anti-sense oligonucleotide is administered in an amount of about 1 to about 50 mg/kg body weight.

130. The method of claim 113, which is a prophylactic method.

131. The method of claim 113, which is a therapeutic method.

132. A method of producing anti-sense oligonucleotide(s) (oligos) consisting of up to and including about 15%> adenosine (A), comprising selecting a target from the group consisting of polypeptides associated with a disease(s) and/or condition(s) afflicting lung airways, genes and RNAs encoding them, the genomic and mRNA flanking regions and the gene(s) and mRNA(s) intron and exon borders; obtaining the sequence of a mRNA(s) selected from the group consisting of mRNAs corresponding to the target gene(s) and mRNAs encoding the target polypeptide(s), genomic and mRNA flanking regions and the genes and mRNAs intron and exon borders; selecting at least one segment ofthe mRNA(s); synthesizing one or more oligo anti-sense to the selected mRNA segment(s); and substituting, if necessary, a universal base(s) for one or more A(s) to reduce the content of A present in the oligo to up to about 15% of all nucleotides.

133. The method of claim 132, wherein the universal base is selected from the group consisting of heteroaromatic bases which bind to a thymidine base but have antagonist activity and less than about 0.3 of the adenosine base agonist activity at the adenosine AΓÇ₧ A_2b and A₃ receptors, and heteroaromatic bases which have no activity or have an agonist activity at the adenosine A_2a receptor.

134. The method of claim 132, wherein all As are substituted with universal bases selected from the group consisting of heteroaromatic bases which bind to a thymidine base but have antagonist activity and less than about 0.3 ofthe adenosine base agonist activity at the adenosine A,, A_2b and A₃ receptors, and heteroaromatic bases which have no activity or have an agonist activity at the adenosine A_2a receptor.

135. The method of claim 133, wherein the heteroaromatic bases are selected from the group consisting of pyrimidines and purines, which may be substituted by O, halo, NH₂, SH, SO, S0₂, S0₃, COOH and branched and fused primary and secondary amino, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkoxy, alkenoxy, acyl, cycloacyl, arylacyl, alkynoxy, cycloalkoxy, aroyl, arylthio, arylsulfoxyl, halocycloalkyl, alkylcycloalkyl, alkenylcycloalkyl, alkynylcycloalkyl, haloaryl, alkylaryl, alkenylaryl, alkynylaryl, arylalkyl, arylalkenyl, arylalkynyl, arylcycloalkyl, which may be further substituted by O, halo, NH₂, primary, secondary and tertiary amine, SH, SO, S0₂, S0₃, cycloalkyl, heterocycloalkyl and heteroaryl.

136. The method of claim 135, wherein the pyrimidines and purines are substituted at positions 1, 2, 3, 4, 7 and 8.

137. The method of claim 135, wherein the pyrimidines and purines are selected from the group consisting of theophylline, caffeine, dyphylline, etophylline, acephylline piperazine, bamifylline, enprofylline and xantine having the chemical formula

wherein R¹ and R² are independently H, alkyl, alkenyl or alkynyl and R³ is H, aryl, dicycloalkyl, dicycloalkenyl, dicycloalkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, O-cycloalkyl, 0-cycloalkenyl, O- cycloalkynyl, NH₂-alkylarnino-ketoxyalkyloxy-aryl and mono and dialkylan╧ämoalkyl-N-alkylamino-S0₂ aryl.

138. The method of claim 135, wherein the universal base is selected from the group consisting of 3- nitropyrrole-2'-deoxynucleoside, 5-nitro-indole, 2-deoxyribosyl-(5-nitroindole), 2-deoxyribofuranosyl-(5- nitroindole), 2'-deoxyinosine, 2'-deoxynebularine, 6H, 8H-3,4-dihydropyrirnido [4,5-c] oxazine-7-one or 2-amino- 6-melhoxya╬╣.╬╣mopurine.

139. The method of claim 132, wherein the proportion of A in the oligo is reduced to up to about 10%.

140. The method of claim 139, wherein the proportion of A in the oligo is reduced to up to about 5%.

141. The method of claim 140, wherein the proportion of A in the oligo is reduced to up to about 3%.

142. The method of claim 141, wherein the proportion of A in the oligo is reduced to about 0.

143. The method of claim 139, wherein the selected segment contains less than about 15%) T.

144. The method of claim 132, further comprising substituting a methylated cytosine for cytosine in at least one CpG dinucleotide present in the anti-sense oligo(s).

145. The method of claim 132, wherein the anti-sense oligo(s) are about 7 to about 60 nucleotides long.

146. The method of claim 132, wherein the target is selected from the group consisting of transcription factors, stimulating and activating factors, interleukins, interleukin receptors, chemokines, chemokine receptors, endogenously produced specific and non-specific enzymes, immunoglobulins, antibody receptors, central nervous system (CNS) and peripheral nervous and non-nervous system receptors, CNS and peripheral nervous and non- nervous system peptide transmitters, adhesion molecules, selectins, defensines, growth factors, vasoactive peptides, vasoactive peptide receptors, and binding proteins and oncogenes.

147. The method of claim 146, wherein the target genes are selected from the group consisting of oncogenes.

148. An anti-sense oligonucleotide produced by the method of claim 132.