WO2000015245A3 - Stable liquid formulations of botulinum toxin - Google Patents

Stable liquid formulations of botulinum toxin Download PDF

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Publication number
WO2000015245A3
WO2000015245A3 PCT/US1999/020912 US9920912W WO0015245A3 WO 2000015245 A3 WO2000015245 A3 WO 2000015245A3 US 9920912 W US9920912 W US 9920912W WO 0015245 A3 WO0015245 A3 WO 0015245A3
Authority
WO
WIPO (PCT)
Prior art keywords
botulinum toxin
liquid formulations
stable liquid
formulations
storage
Prior art date
Application number
PCT/US1999/020912
Other languages
French (fr)
Other versions
WO2000015245A2 (en
Inventor
Elizabeth Moyer
Pamela Hirtzer
Original Assignee
Elan Pharm Inc
Elizabeth Moyer
Pamela Hirtzer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22277018&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2000015245(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to CA2342243A priority Critical patent/CA2342243C/en
Priority to AT99945649T priority patent/ATE221386T1/en
Priority to NZ509349A priority patent/NZ509349A/en
Priority to IL14156499A priority patent/IL141564A0/en
Priority to JP2000569829A priority patent/JP4557426B2/en
Priority to SK313-2001A priority patent/SK286919B6/en
Priority to EA200100337A priority patent/EA003367B1/en
Priority to SI9930126T priority patent/SI1112082T1/en
Priority to DK99945649.4T priority patent/DK1112082T4/en
Application filed by Elan Pharm Inc, Elizabeth Moyer, Pamela Hirtzer filed Critical Elan Pharm Inc
Priority to BR9913585-0A priority patent/BR9913585A/en
Priority to DE69902396T priority patent/DE69902396T3/en
Priority to AU58214/99A priority patent/AU755556C/en
Priority to PL347069A priority patent/PL200926B1/en
Priority to SI9920081A priority patent/SI20566B/en
Priority to APAP/P/2001/002108A priority patent/AP1591A/en
Priority to EP99945649A priority patent/EP1112082B2/en
Priority to HU0103638A priority patent/HUP0103638A3/en
Priority to EEP200100140A priority patent/EE200100140A/en
Priority to UA2001042366A priority patent/UA72477C2/en
Publication of WO2000015245A2 publication Critical patent/WO2000015245A2/en
Publication of WO2000015245A3 publication Critical patent/WO2000015245A3/en
Priority to IS5836A priority patent/IS2381B/en
Priority to IL141564A priority patent/IL141564A/en
Priority to NO20011207A priority patent/NO328898B1/en
Priority to HR20010259A priority patent/HRP20010259B1/en
Priority to LV010056A priority patent/LV12684B/en
Priority to HK02102724.7A priority patent/HK1040927A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893—Botulinum neurotoxin (3.4.24.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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    • A—HUMAN NECESSITIES
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Abstract

The invention includes liquid formulations of botulinum toxin that are stable to storage in liquid form at standard refrigerator temperatures for at least 1-2 years and to storage at higher temperatures for at least 6 months. The invention also includes methods of treatment using such formulations and uses of such formulations in the manufacture of medicaments for various therapeutic and cosmetic treatments.
PCT/US1999/020912 1998-09-11 1999-09-09 Stable liquid formulations of botulinum toxin WO2000015245A2 (en)

Priority Applications (25)

Application Number Priority Date Filing Date Title
AU58214/99A AU755556C (en) 1998-09-11 1999-09-09 Stable liquid formulations of botulinum toxin
PL347069A PL200926B1 (en) 1998-09-11 1999-09-09 STABLE LIQUID FORMULATIONS OF BOTULINUM TOXIN and METHODS OF TREATMENT USING FORMULATIONS OF BOTULINUM TOXIN
NZ509349A NZ509349A (en) 1998-09-11 1999-09-09 Stable liquid formulations of botulinum toxin
IL14156499A IL141564A0 (en) 1998-09-11 1999-09-09 A stable liquid pharmaceutical botulinum toxin formulation
JP2000569829A JP4557426B2 (en) 1998-09-11 1999-09-09 A stable liquid formulation of botulinum toxin
SK313-2001A SK286919B6 (en) 1998-09-11 1999-09-09 Stable liquid pharmaceutical formulations of botulinium toxin and its use
EA200100337A EA003367B1 (en) 1998-09-11 1999-09-09 Stable liquid formulations of botulinum toxin
SI9930126T SI1112082T1 (en) 1998-09-11 1999-09-09 Stable liquid formulations of botulinum toxin
DK99945649.4T DK1112082T4 (en) 1998-09-11 1999-09-09 Stable liquid formulations of botulinum toxin
AT99945649T ATE221386T1 (en) 1998-09-11 1999-09-09 STABILIZED LIQUID MEDICINAL PREPARATIONS CONTAINING BOTULINUM TOXIN
BR9913585-0A BR9913585A (en) 1998-09-11 1999-09-09 Formulation of stable liquid pharmaceutical botulinum toxin, method of treating a patient in need of inhibition of cholinergic entry into a selected muscle, muscle group, gland or organ, and use of a formulation of stable liquid botulinum toxin
DE69902396T DE69902396T3 (en) 1998-09-11 1999-09-09 STABILIZED LIQUID MEDICINE PREPARATIONS CONTAINING BOTULINUM TOXIN
UA2001042366A UA72477C2 (en) 1998-09-11 1999-09-09 Stable liquid formulations of botulinum toxin (variants), methods of treatment using formulations of botulinum toxin (variants)
CA2342243A CA2342243C (en) 1998-09-11 1999-09-09 Stable liquid formulations of botulinum toxin
EEP200100140A EE200100140A (en) 1998-09-11 1999-09-09 Stable liquid formulations of botulinum toxin
APAP/P/2001/002108A AP1591A (en) 1998-09-11 1999-09-09 Stable liquid formulations of botulinum toxin
EP99945649A EP1112082B2 (en) 1998-09-11 1999-09-09 Stable liquid formulations of botulinum toxin
HU0103638A HUP0103638A3 (en) 1998-09-11 1999-09-09 Stable liquid formulations of botulinum toxin
SI9920081A SI20566B (en) 1998-09-11 1999-09-09 Stable liquid formulations of botulinum toxin
IS5836A IS2381B (en) 1998-09-11 2001-01-31 Stable liquid formulations of botulinum toxin
IL141564A IL141564A (en) 1998-09-11 2001-02-21 Stable liquid pharmaceutical botulinum toxin formulation
NO20011207A NO328898B1 (en) 1998-09-11 2001-03-09 Stable, liquid pharmaceutical formulations of botulinum toxin, and their use.
HR20010259A HRP20010259B1 (en) 1998-09-11 2001-04-09 Stable liquid formulations of botulinum toxin
LV010056A LV12684B (en) 1998-09-11 2001-04-10 Botulinum toxic stable liquid compositions
HK02102724.7A HK1040927A1 (en) 1998-09-11 2002-04-10 Stable liquid formulations of botulinum toxin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9987098P 1998-09-11 1998-09-11
US60/099,870 1998-09-11

Publications (2)

Publication Number Publication Date
WO2000015245A2 WO2000015245A2 (en) 2000-03-23
WO2000015245A3 true WO2000015245A3 (en) 2000-06-08

Family

ID=22277018

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/020912 WO2000015245A2 (en) 1998-09-11 1999-09-09 Stable liquid formulations of botulinum toxin

Country Status (41)

Country Link
US (2) US7211261B1 (en)
EP (1) EP1112082B2 (en)
JP (4) JP4557426B2 (en)
KR (1) KR100699756B1 (en)
CN (1) CN100438905C (en)
AP (1) AP1591A (en)
AR (1) AR022671A1 (en)
AT (1) ATE221386T1 (en)
AU (1) AU755556C (en)
BG (1) BG65555B1 (en)
BR (1) BR9913585A (en)
CA (1) CA2342243C (en)
CO (1) CO5170497A1 (en)
CU (1) CU23251A3 (en)
DE (1) DE69902396T3 (en)
DK (1) DK1112082T4 (en)
EA (1) EA003367B1 (en)
EE (1) EE200100140A (en)
ES (1) ES2181473T5 (en)
GE (1) GEP20032946B (en)
HK (1) HK1040927A1 (en)
HR (1) HRP20010259B1 (en)
HU (1) HUP0103638A3 (en)
ID (1) ID28824A (en)
IL (2) IL141564A0 (en)
IS (1) IS2381B (en)
LT (1) LT4959B (en)
LV (1) LV12684B (en)
NO (1) NO328898B1 (en)
NZ (1) NZ509349A (en)
PL (1) PL200926B1 (en)
PT (1) PT1112082E (en)
RS (1) RS50344B (en)
SA (1) SA99200566B1 (en)
SI (2) SI1112082T1 (en)
SK (1) SK286919B6 (en)
TR (1) TR200100728T2 (en)
TW (1) TW574036B (en)
UA (1) UA72477C2 (en)
WO (1) WO2000015245A2 (en)
ZA (1) ZA200101709B (en)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2238969T3 (en) * 1994-05-09 2005-09-16 William J. Binder PRESINAPTIC NEUROTOXINS FOR THE TREATMENT OF MIGRAINE HEADS.
US20120238504A1 (en) * 1998-09-11 2012-09-20 Solstice Neurosciences, Llc Stable Formulations of Botulinum Toxin in Hydrogels
TW574036B (en) * 1998-09-11 2004-02-01 Elan Pharm Inc Stable liquid compositions of botulinum toxin
DE19925739A1 (en) * 1999-06-07 2000-12-21 Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh Therapeutic with a botulinum neurotoxin
US7838007B2 (en) 1999-12-07 2010-11-23 Allergan, Inc. Methods for treating mammary gland disorders
US7838008B2 (en) 1999-12-07 2010-11-23 Allergan, Inc. Methods for treating diverse cancers
US8632785B2 (en) * 2000-02-08 2014-01-21 Allergan, Inc. Clostridial toxin pharmaceutical composition containing a gelatin fragment
US7780967B2 (en) 2000-02-08 2010-08-24 Allergan, Inc. Reduced toxicity Clostridial toxin pharmaceutical compositions
MXPA02007519A (en) * 2000-02-08 2004-10-15 Allergan Inc Botulinum toxin pharmaceutical compositions.
US20030118598A1 (en) * 2000-02-08 2003-06-26 Allergan, Inc. Clostridial toxin pharmaceutical compositions
US20060269575A1 (en) * 2000-02-08 2006-11-30 Allergan, Inc. Botulinum toxin pharmaceutical compositions formulated with recombinant albumin
US6821520B2 (en) 2000-02-15 2004-11-23 Allergan, Inc. Clostridial toxin therapy for Hashimoto's thyroiditis
ITUD20010002A1 (en) * 2001-01-05 2002-07-05 Univ Degli Studi Udine USE OF BOTULIN TOXIN FOR THE SOLUTION OF JOINT PATHOLOGIES, IN PARTICULAR OF COXARTROSIS, EPICONDYLITIS AND PATHOLUS
CA2369810C (en) * 2002-01-30 2007-08-07 1474791 Ontario Limited Method of treating pain
US7140371B2 (en) 2002-03-14 2006-11-28 Allergan, Inc. Surface topography method for determining effects of a botulinum toxin upon a muscle and for comparing botulinum toxins
US6688311B2 (en) 2002-03-14 2004-02-10 Allergan, Inc. Method for determining effect of a clostridial toxin upon a muscle
AU2003221050A1 (en) * 2002-03-29 2003-10-13 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Remedy for hypermyotonia
US7691394B2 (en) * 2002-05-28 2010-04-06 Botulinum Toxin Research Associates, Inc. High-potency botulinum toxin formulations
US20040009180A1 (en) * 2002-07-11 2004-01-15 Allergan, Inc. Transdermal botulinum toxin compositions
EP1565210B1 (en) 2002-11-21 2012-01-11 Ira Sanders Clostridial neurotoxin for use in the treatment of nasal congestion
BR0316871A (en) * 2002-12-20 2005-10-18 Botulinum Toxin Res Ass Inc Botulically improved toxin pharmaceutical compositions
US8071550B2 (en) 2003-03-03 2011-12-06 Allergan, Inc. Methods for treating uterine disorders
US7670608B2 (en) * 2003-03-06 2010-03-02 Botulinum Toxin Research Associates, Inc. Selection of patients with increased responsiveness to botulinum toxin
WO2004078201A1 (en) * 2003-03-06 2004-09-16 Botulinum Toxin Research Associates, Inc. Treatment of sinusitis related chronic facial pain and headache with botulinum toxin
US6838434B2 (en) * 2003-05-02 2005-01-04 Allergan, Inc. Methods for treating sinus headache
US7220422B2 (en) * 2003-05-20 2007-05-22 Allergan, Inc. Methods and compositions for treating eye disorders
US8734810B2 (en) 2003-10-29 2014-05-27 Allergan, Inc. Botulinum toxin treatments of neurological and neuropsychiatric disorders
US8617572B2 (en) 2003-10-29 2013-12-31 Allergan, Inc. Botulinum toxin treatments of depression
US8609112B2 (en) 2003-10-29 2013-12-17 Allergan, Inc. Botulinum toxin treatments of depression
US8609113B2 (en) 2003-10-29 2013-12-17 Allergan, Inc. Botulinum toxin treatments of depression
US9211248B2 (en) 2004-03-03 2015-12-15 Revance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
SG10201803560WA (en) 2004-03-03 2018-06-28 Revance Therapeutics Inc Compositions And Methods For Topical Application And Transdermal Delivery Of Botulinum Toxins
AU2005251676B2 (en) 2004-03-03 2011-09-29 Revance Therapeutics, Inc. Compositions and methods for topical diagnostic and therapeutic transport
CN101005853B (en) * 2004-07-26 2011-05-04 莫茨药物股份两合公司 Therapeutic composition with a botulinum neurotoxin
US7179474B2 (en) 2004-09-03 2007-02-20 Allergan, Inc. Methods for treating a buttock deformity
US7429386B2 (en) 2004-09-03 2008-09-30 Allergan, Inc. Stretch mark treatment
WO2006073410A1 (en) * 2005-01-03 2006-07-13 Botulinum Toxin Research Associates, Inc. Compositions, methods and devices for preparing less painful botulinum toxin formulations
AU2006218431B2 (en) 2005-03-03 2012-12-06 Revance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
US7419675B2 (en) 2005-05-26 2008-09-02 Allergan, Inc. Method for treating peritoneal adhesions
US8323666B2 (en) * 2005-08-01 2012-12-04 Allergan, Inc. Botulinum toxin compositions
US8137677B2 (en) 2005-10-06 2012-03-20 Allergan, Inc. Non-protein stabilized clostridial toxin pharmaceutical compositions
US8168206B1 (en) 2005-10-06 2012-05-01 Allergan, Inc. Animal protein-free pharmaceutical compositions
DE102006019447A1 (en) * 2006-04-24 2007-10-25 Dressler, Dirk, Dr. Medicament, useful to treat diseases e.g. headache, hyperhidrosis and muscular pain, comprises botulinum toxin and at least a marker, preferably a saline-solution
AR061669A1 (en) * 2006-06-29 2008-09-10 Merz Pharma Gmbh & Co Kgaa HIGH FREQUENCY THERAPY APPLICATION WITH BOTULIN TOXIN
US10792344B2 (en) 2006-06-29 2020-10-06 Merz Pharma Gmbh & Co. Kgaa High frequency application of botulinum toxin therapy
BRPI0812245A2 (en) * 2007-06-01 2014-10-21 Merz Pharma Gmbh & Co Kgaa METHOD FOR PROVISION OF A THERMOSTABLE MUSCULAR RELAXING BASED ON THE NEUTROTOXIC COMPONENT OF BOTULINIC TOXIN IN SOLID FORM
EP2048156A1 (en) * 2007-10-12 2009-04-15 Merz Pharma GmbH & Co.KGaA Process for providing a temperature-stable muscle relaxant on the basis of the neurotoxic component of botulinum toxin
US9107815B2 (en) 2008-02-22 2015-08-18 Allergan, Inc. Sustained release poloxamer containing pharmaceutical compositions
US20170361130A9 (en) * 2008-05-23 2017-12-21 Pankaj Modi Stabilized and solubilized drug formulation for topical application and transdermal efficacy for cosmetic improvement and methods of formulation
US20100034854A1 (en) * 2008-08-05 2010-02-11 Solstice Neurosciences, Inc. Compositions of activated botulinum holotoxin type B (150 KD)
US20100034853A1 (en) * 2008-08-05 2010-02-11 Solstice Neurosciences, Inc. Compositions of activated botulinum toxin type B
US20100112006A1 (en) * 2008-11-03 2010-05-06 Solstice Neurosciences, Inc. Compositions of activated botulinum holotoxin type B (150 kD)
WO2010051039A1 (en) * 2008-11-03 2010-05-06 Solstice Neurosciences, Inc. Compositions of activated botulinum toxin type b
US20100124559A1 (en) * 2008-11-20 2010-05-20 Allergan, Inc. Early Treatment and Prevention of Increased Muscle Tonicity
US9066851B2 (en) 2008-12-04 2015-06-30 Botulinum Toxin Research Associates, Inc. Extended length botulinum toxin formulation for human or mammalian use
PL2379104T3 (en) 2008-12-31 2018-07-31 Revance Therapeutics, Inc. Injectable botulinum toxin formulations
EP2248518B1 (en) * 2009-04-17 2013-01-16 Merz Pharma GmbH & Co. KGaA Formulation for stabilizing proteins, peptides or mixtures thereof.
CA2766521C (en) 2009-06-25 2020-07-21 Revance Therapeutics, Inc. Albumin-free botulinum toxin formulations
CA2763692A1 (en) 2009-07-02 2011-01-06 Merz Pharma Gmbh & Co. Kgaa Neurotoxins exhibiting shortened biological activity
MX365496B (en) 2009-10-21 2019-06-05 Revance Therapeutics Inc Methods and systems for purifying non-complexed botulinum neurotoxin.
AU2012209274A1 (en) * 2011-01-24 2013-09-12 Anterios, Inc. Nanoparticle compositions, formulations thereof, and uses therefor
JP6162135B2 (en) 2011-11-09 2017-07-12 メルツ ファルマ ゲーエムベーハー ウント コンパニー カーゲーアーアー Neurotoxins with shortened biological activity
US9393291B2 (en) 2012-04-12 2016-07-19 Botulinum Toxin Research Associates, Inc. Use of botulinum toxin for the treatment of cerebrovascular disease, renovascular and retinovascular circulatory beds
WO2014066916A2 (en) 2012-10-28 2014-05-01 Revance Therapeutics, Inc. Compositions and methods for safe treatment of rhinitis
RU2535115C1 (en) 2013-05-15 2014-12-10 Бости Трейдинг Лтд Pharmaceutical formulation containing botulinum neurotoxin
US11484580B2 (en) 2014-07-18 2022-11-01 Revance Therapeutics, Inc. Topical ocular preparation of botulinum toxin for use in ocular surface disease
US9901627B2 (en) 2014-07-18 2018-02-27 Revance Therapeutics, Inc. Topical ocular preparation of botulinum toxin for use in ocular surface disease
CA2959859C (en) 2014-09-02 2023-05-09 American Silver, Llc Botulinum toxin and colloidal silver particles
WO2016102068A1 (en) * 2014-12-23 2016-06-30 Merz Pharma Gmbh & Co. Kgaa Botulinum toxin prefilled container
SG11201706247VA (en) * 2015-02-03 2017-08-30 Merz Pharma Gmbh & Co Kgaa Botulinum toxin prefilled container
JP7053498B2 (en) * 2016-05-27 2022-04-12 ガルデルマ・ホールディング・エスアー Liquid neurotoxin product stabilized with tryptophan or tyrosine
WO2018038301A1 (en) * 2016-08-26 2018-03-01 Hugel Inc. Stabilized liquid formulation of botulinum toxin and preparation method thereof
SI3436054T2 (en) 2016-09-13 2022-09-30 Allergan, Inc. Stabilized non-protein clostridial toxin compositions
CN117731591A (en) 2016-11-21 2024-03-22 艾里奥治疗公司 Transdermal delivery of large agents
KR101744900B1 (en) 2017-01-20 2017-06-08 주식회사 대웅 Stable Liquid Composition Comprising Botulinum Toxin
RU2019141383A (en) * 2017-05-18 2021-06-18 Реванс Терапьютикс, Инк. (Revance Therapeutics, Inc.) METHODS FOR TREATMENT OF CERVICAL DYSTONIA
KR102063475B1 (en) 2018-02-22 2020-01-09 주식회사 에이비바이오 The stabilized liquid formulations comprising a botulinum toxin, a stabilizer, and a local anesthetic, and a method of producing thereof
JP2022514151A (en) 2018-10-08 2022-02-10 メルツ ファルマ ゲーエムベーハー ウント コンパニー カーゲーアーアー Neurotoxin prefilled vial

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994000481A1 (en) * 1992-06-23 1994-01-06 Associated Synapse Biologics Pharmaceutical composition containing botulinum b complex
EP0593176A2 (en) * 1992-09-28 1994-04-20 Wisconsin Alumni Research Foundation Pharmaceutical compositions containing botulinum toxin and method of preparation
WO1996011699A1 (en) * 1994-10-13 1996-04-25 Wisconsin Alumni Research Foundation Pharmaceutical composition of botulinum neurotoxin and method of preparation
WO1997035604A1 (en) * 1996-03-27 1997-10-02 Wisconsin Alumni Research Foundation Pharmaceutical compositions of botulinum toxin or botulinum neurotoxin and methods of preparation

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3522247A (en) * 1967-11-07 1970-07-28 Pfizer & Co C 2-amino-6,7-disubstituted-4h-1,3-benzothiazine-4-ones as bronchodilators
US4932936A (en) 1988-01-29 1990-06-12 Regents Of The University Of Minnesota Method and device for pharmacological control of spasticity
US5053005A (en) 1989-04-21 1991-10-01 Gary E. Borodic Chemomodulation of curvature of the juvenile spine
US5919665A (en) * 1989-10-31 1999-07-06 Ophidian Pharmaceuticals, Inc. Vaccine for clostridium botulinum neurotoxin
US5183462A (en) * 1990-08-21 1993-02-02 Associated Synapse Biologics Controlled administration of chemodenervating pharmaceuticals
GB9120306D0 (en) 1991-09-24 1991-11-06 Graham Herbert K Method and compositions for the treatment of cerebral palsy
DE69429619T2 (en) 1993-06-10 2002-09-12 Allergan Inc TREATMENT OF NEUROMUSCULAR DISORDERS AND CONDITIONS WITH BOTULISM SEROTYPE E
JP4249802B2 (en) 1993-06-10 2009-04-08 アラーガン、インコーポレイテッド Botulinum toxin combination for treating neuromuscular diseases and symptoms
GB9315306D0 (en) 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
US5437291A (en) 1993-08-26 1995-08-01 Univ Johns Hopkins Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction
DE69427869T2 (en) 1993-12-28 2002-04-11 Allergan Sales Inc BOTULINUMTOXINS FOR TREATING HYPERHYDROSIS
US6974578B1 (en) * 1993-12-28 2005-12-13 Allergan, Inc. Method for treating secretions and glands using botulinum toxin
US5766605A (en) 1994-04-15 1998-06-16 Mount Sinai School Of Medicine Of The City University Of New York Treatment of autonomic nerve dysfunction with botulinum toxin
ES2238969T3 (en) 1994-05-09 2005-09-16 William J. Binder PRESINAPTIC NEUROTOXINS FOR THE TREATMENT OF MIGRAINE HEADS.
AU2907695A (en) * 1994-08-08 1996-03-07 Wisconsin Alumni Research Foundation Purification and pharmaceutical compositions containing type g botulinum neurotoxin
US5562899A (en) 1995-02-28 1996-10-08 Gerber; Allen Medical prevention of lacerations to the vagina and perineum
US6136551A (en) * 1995-04-24 2000-10-24 Allergan, Inc. Assay for detecting the presence of botulinum toxin neutralizing antibodies in a patient serum sample
ES2198484T3 (en) 1995-06-06 2004-02-01 L. Bruce Pearce COMPOSITIONS AND IMPROVED PROCEDURES FOR CHEMICALDERVATION USING NEUROTOXINS.
US5721215A (en) 1996-03-20 1998-02-24 Allergan Injectable therapy for control of muscle spasms and pain related to muscle spasms
US6699966B1 (en) * 1996-07-08 2004-03-02 University Of Massachusetts Proteins within the type E botulinum neurotoxin complex
CN1057430C (en) * 1996-10-09 2000-10-18 崔生发 Biochemical rodenticide
TW574036B (en) * 1998-09-11 2004-02-01 Elan Pharm Inc Stable liquid compositions of botulinum toxin
US6146902A (en) * 1998-12-29 2000-11-14 Aventis Pasteur, Inc. Purification of polysaccharide-protein conjugate vaccines by ultrafiltration with ammonium sulfate solutions
US6113915A (en) 1999-10-12 2000-09-05 Allergan Sales, Inc. Methods for treating pain
US6139845A (en) 1999-12-07 2000-10-31 Allergan Sales, Inc. Method for treating cancer with a neurotoxin
US20030118598A1 (en) * 2000-02-08 2003-06-26 Allergan, Inc. Clostridial toxin pharmaceutical compositions
MXPA02007519A (en) * 2000-02-08 2004-10-15 Allergan Inc Botulinum toxin pharmaceutical compositions.
US6358513B1 (en) 2000-02-15 2002-03-19 Allergan Sales, Inc. Method for treating Hashimoto's thyroiditis
US6464986B1 (en) * 2000-04-14 2002-10-15 Allegan Sales, Inc. Method for treating pain by peripheral administration of a neurotoxin
US20080096238A1 (en) * 2004-03-30 2008-04-24 Alcon, Inc. High throughput assay for human rho kinase activity with enhanced signal-to-noise ratio
CN1930186A (en) * 2005-03-03 2007-03-14 阿勒根公司 Media for clostridium bacterium and processes for obtaining a clostridial toxin
EP2316847A3 (en) 2005-03-15 2012-01-18 Allergan, Inc. Modified clostridial toxins with enhanced targeting capabilities for endogenous clostridial toxin receptor systems
US20080118532A1 (en) * 2006-06-01 2008-05-22 Atassi M Zouhair Determining and reducing immunoresistance to a botulinum toxin therapy using botulinum toxin b peptides

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994000481A1 (en) * 1992-06-23 1994-01-06 Associated Synapse Biologics Pharmaceutical composition containing botulinum b complex
EP0593176A2 (en) * 1992-09-28 1994-04-20 Wisconsin Alumni Research Foundation Pharmaceutical compositions containing botulinum toxin and method of preparation
WO1996011699A1 (en) * 1994-10-13 1996-04-25 Wisconsin Alumni Research Foundation Pharmaceutical composition of botulinum neurotoxin and method of preparation
WO1997035604A1 (en) * 1996-03-27 1997-10-02 Wisconsin Alumni Research Foundation Pharmaceutical compositions of botulinum toxin or botulinum neurotoxin and methods of preparation

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