WO2000015245A3 - Stable liquid formulations of botulinum toxin - Google Patents

Stable liquid formulations of botulinum toxin Download PDF

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Publication number
WO2000015245A3
WO2000015245A3 PCT/US1999/020912 US9920912W WO0015245A3 WO 2000015245 A3 WO2000015245 A3 WO 2000015245A3 US 9920912 W US9920912 W US 9920912W WO 0015245 A3 WO0015245 A3 WO 0015245A3
Authority
WO
WIPO (PCT)
Prior art keywords
botulinum toxin
liquid formulations
stable liquid
formulations
storage
Prior art date
Application number
PCT/US1999/020912
Other languages
French (fr)
Other versions
WO2000015245A2 (en
Inventor
Elizabeth Moyer
Pamela Hirtzer
Original Assignee
Elan Pharm Inc
Elizabeth Moyer
Pamela Hirtzer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22277018&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2000015245(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to SI9920081A priority Critical patent/SI20566B/en
Priority to PL347069A priority patent/PL200926B1/en
Priority to EEP200100140A priority patent/EE200100140A/en
Priority to UA2001042366A priority patent/UA72477C2/en
Priority to NZ509349A priority patent/NZ509349A/en
Priority to CA2342243A priority patent/CA2342243C/en
Priority to HU0103638A priority patent/HUP0103638A3/en
Priority to BR9913585-0A priority patent/BR9913585A/en
Priority to DK99945649.4T priority patent/DK1112082T4/en
Application filed by Elan Pharm Inc, Elizabeth Moyer, Pamela Hirtzer filed Critical Elan Pharm Inc
Priority to SI9930126T priority patent/SI1112082T1/en
Priority to DE69902396T priority patent/DE69902396T3/en
Priority to APAP/P/2001/002108A priority patent/AP1591A/en
Priority to IL14156499A priority patent/IL141564A0/en
Priority to AU58214/99A priority patent/AU755556C/en
Priority to EP99945649A priority patent/EP1112082B2/en
Priority to AT99945649T priority patent/ATE221386T1/en
Priority to EA200100337A priority patent/EA003367B1/en
Priority to SK313-2001A priority patent/SK286919B6/en
Priority to JP2000569829A priority patent/JP4557426B2/en
Publication of WO2000015245A2 publication Critical patent/WO2000015245A2/en
Publication of WO2000015245A3 publication Critical patent/WO2000015245A3/en
Priority to IS5836A priority patent/IS2381B/en
Priority to IL141564A priority patent/IL141564A/en
Priority to NO20011207A priority patent/NO328898B1/en
Priority to HR20010259A priority patent/HRP20010259B1/en
Priority to LV010056A priority patent/LV12684B/en
Priority to HK02102724.7A priority patent/HK1040927A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893—Botulinum neurotoxin (3.4.24.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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Abstract

The invention includes liquid formulations of botulinum toxin that are stable to storage in liquid form at standard refrigerator temperatures for at least 1-2 years and to storage at higher temperatures for at least 6 months. The invention also includes methods of treatment using such formulations and uses of such formulations in the manufacture of medicaments for various therapeutic and cosmetic treatments.
PCT/US1999/020912 1998-09-11 1999-09-09 Stable liquid formulations of botulinum toxin WO2000015245A2 (en)

Priority Applications (25)

Application Number Priority Date Filing Date Title
APAP/P/2001/002108A AP1591A (en) 1998-09-11 1999-09-09 Stable liquid formulations of botulinum toxin
IL14156499A IL141564A0 (en) 1998-09-11 1999-09-09 A stable liquid pharmaceutical botulinum toxin formulation
EEP200100140A EE200100140A (en) 1998-09-11 1999-09-09 Stable liquid formulations of botulinum toxin
UA2001042366A UA72477C2 (en) 1998-09-11 1999-09-09 Stable liquid formulations of botulinum toxin (variants), methods of treatment using formulations of botulinum toxin (variants)
NZ509349A NZ509349A (en) 1998-09-11 1999-09-09 Stable liquid formulations of botulinum toxin
CA2342243A CA2342243C (en) 1998-09-11 1999-09-09 Stable liquid formulations of botulinum toxin
HU0103638A HUP0103638A3 (en) 1998-09-11 1999-09-09 Stable liquid formulations of botulinum toxin
BR9913585-0A BR9913585A (en) 1998-09-11 1999-09-09 Formulation of stable liquid pharmaceutical botulinum toxin, method of treating a patient in need of inhibition of cholinergic entry into a selected muscle, muscle group, gland or organ, and use of a formulation of stable liquid botulinum toxin
DK99945649.4T DK1112082T4 (en) 1998-09-11 1999-09-09 Stable liquid formulations of botulinum toxin
PL347069A PL200926B1 (en) 1998-09-11 1999-09-09 STABLE LIQUID FORMULATIONS OF BOTULINUM TOXIN and METHODS OF TREATMENT USING FORMULATIONS OF BOTULINUM TOXIN
SI9930126T SI1112082T1 (en) 1998-09-11 1999-09-09 Stable liquid formulations of botulinum toxin
DE69902396T DE69902396T3 (en) 1998-09-11 1999-09-09 STABILIZED LIQUID MEDICINE PREPARATIONS CONTAINING BOTULINUM TOXIN
JP2000569829A JP4557426B2 (en) 1998-09-11 1999-09-09 A stable liquid formulation of botulinum toxin
SI9920081A SI20566B (en) 1998-09-11 1999-09-09 Stable liquid formulations of botulinum toxin
SK313-2001A SK286919B6 (en) 1998-09-11 1999-09-09 Stable liquid pharmaceutical formulations of botulinium toxin and its use
EP99945649A EP1112082B2 (en) 1998-09-11 1999-09-09 Stable liquid formulations of botulinum toxin
AT99945649T ATE221386T1 (en) 1998-09-11 1999-09-09 STABILIZED LIQUID MEDICINAL PREPARATIONS CONTAINING BOTULINUM TOXIN
EA200100337A EA003367B1 (en) 1998-09-11 1999-09-09 Stable liquid formulations of botulinum toxin
AU58214/99A AU755556C (en) 1998-09-11 1999-09-09 Stable liquid formulations of botulinum toxin
IS5836A IS2381B (en) 1998-09-11 2001-01-31 Stable liquid formulations of botulinum toxin
IL141564A IL141564A (en) 1998-09-11 2001-02-21 Stable liquid pharmaceutical botulinum toxin formulation
NO20011207A NO328898B1 (en) 1998-09-11 2001-03-09 Stable, liquid pharmaceutical formulations of botulinum toxin, and their use.
HR20010259A HRP20010259B1 (en) 1998-09-11 2001-04-09 Stable liquid formulations of botulinum toxin
LV010056A LV12684B (en) 1998-09-11 2001-04-10 Botulinum toxic stable liquid compositions
HK02102724.7A HK1040927A1 (en) 1998-09-11 2002-04-10 Stable liquid formulations of botulinum toxin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9987098P 1998-09-11 1998-09-11
US60/099,870 1998-09-11

Publications (2)

Publication Number Publication Date
WO2000015245A2 WO2000015245A2 (en) 2000-03-23
WO2000015245A3 true WO2000015245A3 (en) 2000-06-08

Family

ID=22277018

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/020912 WO2000015245A2 (en) 1998-09-11 1999-09-09 Stable liquid formulations of botulinum toxin

Country Status (41)

Country Link
US (2) US7211261B1 (en)
EP (1) EP1112082B2 (en)
JP (4) JP4557426B2 (en)
KR (1) KR100699756B1 (en)
CN (1) CN100438905C (en)
AP (1) AP1591A (en)
AR (1) AR022671A1 (en)
AT (1) ATE221386T1 (en)
AU (1) AU755556C (en)
BG (1) BG65555B1 (en)
BR (1) BR9913585A (en)
CA (1) CA2342243C (en)
CO (1) CO5170497A1 (en)
CU (1) CU23251A3 (en)
DE (1) DE69902396T3 (en)
DK (1) DK1112082T4 (en)
EA (1) EA003367B1 (en)
EE (1) EE200100140A (en)
ES (1) ES2181473T5 (en)
GE (1) GEP20032946B (en)
HK (1) HK1040927A1 (en)
HR (1) HRP20010259B1 (en)
HU (1) HUP0103638A3 (en)
ID (1) ID28824A (en)
IL (2) IL141564A0 (en)
IS (1) IS2381B (en)
LT (1) LT4959B (en)
LV (1) LV12684B (en)
NO (1) NO328898B1 (en)
NZ (1) NZ509349A (en)
PL (1) PL200926B1 (en)
PT (1) PT1112082E (en)
RS (1) RS50344B (en)
SA (1) SA99200566B1 (en)
SI (2) SI1112082T1 (en)
SK (1) SK286919B6 (en)
TR (1) TR200100728T2 (en)
TW (1) TW574036B (en)
UA (1) UA72477C2 (en)
WO (1) WO2000015245A2 (en)
ZA (1) ZA200101709B (en)

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US20120238504A1 (en) * 1998-09-11 2012-09-20 Solstice Neurosciences, Llc Stable Formulations of Botulinum Toxin in Hydrogels
DE19925739A1 (en) * 1999-06-07 2000-12-21 Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh Therapeutic with a botulinum neurotoxin
US7838007B2 (en) 1999-12-07 2010-11-23 Allergan, Inc. Methods for treating mammary gland disorders
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US8632785B2 (en) * 2000-02-08 2014-01-21 Allergan, Inc. Clostridial toxin pharmaceutical composition containing a gelatin fragment
US6821520B2 (en) 2000-02-15 2004-11-23 Allergan, Inc. Clostridial toxin therapy for Hashimoto's thyroiditis
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US6688311B2 (en) 2002-03-14 2004-02-10 Allergan, Inc. Method for determining effect of a clostridial toxin upon a muscle
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CA2854831C (en) 2002-11-21 2016-08-30 Ira Sanders Treatment of mammalian reaction to ige interactions
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US8071550B2 (en) 2003-03-03 2011-12-06 Allergan, Inc. Methods for treating uterine disorders
EP1599220B1 (en) * 2003-03-06 2013-07-17 Botulinum Toxin Research Associates, Inc. Selection of patients with increased responsiveness to botulinum toxin
ZA200506715B (en) * 2003-03-06 2007-05-30 Botulinum Toxin Res Ass Inc Treatment of sinusitis related chronic facial pain and headache with botulinum toxin
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