WO2000015256A3 - Emulsion immunostimulante - Google Patents

Emulsion immunostimulante Download PDF

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Publication number
WO2000015256A3
WO2000015256A3 PCT/FR1999/002177 FR9902177W WO0015256A3 WO 2000015256 A3 WO2000015256 A3 WO 2000015256A3 FR 9902177 W FR9902177 W FR 9902177W WO 0015256 A3 WO0015256 A3 WO 0015256A3
Authority
WO
WIPO (PCT)
Prior art keywords
immunostimulant
emulsion
concerns
oil
immunostimulant emulsion
Prior art date
Application number
PCT/FR1999/002177
Other languages
English (en)
Other versions
WO2000015256A2 (fr
Inventor
Jean Haensler
Original Assignee
Pasteur Merieux Serums Vacc
Jean Haensler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Merieux Serums Vacc, Jean Haensler filed Critical Pasteur Merieux Serums Vacc
Priority to AU56278/99A priority Critical patent/AU749282B2/en
Priority to US09/786,532 priority patent/US6610308B1/en
Priority to NZ510419A priority patent/NZ510419A/xx
Priority to EP99942961A priority patent/EP1121148A2/fr
Priority to CA002342313A priority patent/CA2342313A1/fr
Publication of WO2000015256A2 publication Critical patent/WO2000015256A2/fr
Publication of WO2000015256A3 publication Critical patent/WO2000015256A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59

Abstract

La présente invention concerne une émulsion immunostimulante de type huile dans eau, qui comprend une phase aqueuse et une phase huileuse, caractérisée en ce qu'elle comprend en outre au moins un polynucléotide immunostimulant dont au moins une partie est couplée de façon covalente à au moins une molécule lipidique. L'invention concerne également une composition vaccinale comprenant à titre d'immunoadjuvant, une telle émulsion.
PCT/FR1999/002177 1998-09-11 1999-09-13 Emulsion immunostimulante WO2000015256A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU56278/99A AU749282B2 (en) 1998-09-11 1999-09-13 Immunostimulant emulsion
US09/786,532 US6610308B1 (en) 1998-09-11 1999-09-13 Immunostimulant emulsion
NZ510419A NZ510419A (en) 1998-09-11 1999-09-13 A vaccine adjuvant that is an oil-in-water immunoslimulant emulsion
EP99942961A EP1121148A2 (fr) 1998-09-11 1999-09-13 Emulsion immunostimulante
CA002342313A CA2342313A1 (fr) 1998-09-11 1999-09-13 Emulsion immunostimulante

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9811520A FR2783170B1 (fr) 1998-09-11 1998-09-11 Emulsion immunostimulante
FR98/11520 1998-09-11

Publications (2)

Publication Number Publication Date
WO2000015256A2 WO2000015256A2 (fr) 2000-03-23
WO2000015256A3 true WO2000015256A3 (fr) 2000-07-13

Family

ID=9530468

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1999/002177 WO2000015256A2 (fr) 1998-09-11 1999-09-13 Emulsion immunostimulante

Country Status (7)

Country Link
US (1) US6610308B1 (fr)
EP (1) EP1121148A2 (fr)
AU (1) AU749282B2 (fr)
CA (1) CA2342313A1 (fr)
FR (1) FR2783170B1 (fr)
NZ (1) NZ510419A (fr)
WO (1) WO2000015256A2 (fr)

Families Citing this family (29)

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Publication number Priority date Publication date Assignee Title
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US7935675B1 (en) 1994-07-15 2011-05-03 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6239116B1 (en) * 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US20030026782A1 (en) * 1995-02-07 2003-02-06 Arthur M. Krieg Immunomodulatory oligonucleotides
US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
ES2628744T3 (es) 1998-05-22 2017-08-03 Ottawa Hospital Research Institute Métodos y productos para inducir inmunidad en mucosas
US20030022854A1 (en) 1998-06-25 2003-01-30 Dow Steven W. Vaccines using nucleic acid-lipid complexes
EP2204186B1 (fr) 1999-02-17 2016-04-06 CSL Limited Complexes immunogènes et méthodes y relatives
WO2001037869A1 (fr) * 1999-11-19 2001-05-31 Csl Limited Compositions vaccinales
US7585847B2 (en) * 2000-02-03 2009-09-08 Coley Pharmaceutical Group, Inc. Immunostimulatory nucleic acids for the treatment of asthma and allergy
FR2814958B1 (fr) * 2000-10-06 2003-03-07 Aventis Pasteur Composition vaccinale
ATE411054T1 (de) 2001-08-17 2008-10-15 Coley Pharm Gmbh Kombinations-motif-immunstimulierende oligonukleotide mit verbesserter wirkung
CN100438908C (zh) * 2001-10-06 2008-12-03 梅瑞尔有限公司 CpG制剂及相关方法
US7576066B2 (en) 2002-07-03 2009-08-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7807803B2 (en) 2002-07-03 2010-10-05 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7605138B2 (en) 2002-07-03 2009-10-20 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US20040053880A1 (en) 2002-07-03 2004-03-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7569553B2 (en) 2002-07-03 2009-08-04 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
BR0315810A (pt) 2002-10-29 2005-09-13 Coley Pharmaceutical Group Ltd Uso de oligonucleotìdeos cpg no tratamento de infecção por vìrus da hepatite c
CA2502015A1 (fr) 2002-12-11 2004-06-24 Coley Pharmaceutical Group, Inc. Acides nucleiques 5'cpg et leurs methodes d'utilisation
EP1663316A2 (fr) 2003-09-25 2006-06-07 Coley Pharmaceutical Group, Inc. Conjugues lipophiles d'acides nucleiques
WO2006080946A2 (fr) * 2004-06-08 2006-08-03 Coley Pharmaceutical Gmbh Oligonucleotide abasique utilise en tant que plate-forme support pour un antigene ainsi qu'un agoniste et un antagoniste immunostimulatoire
KR101251707B1 (ko) 2006-09-27 2013-04-11 콜리 파마슈티칼 게엠베하 면역 자극 활성이 증강된 소수성 Ｔ 유사체를 함유하는 ＣｐＧ 올리고뉴클레오티드 유사체
BR112012030337B1 (pt) * 2010-05-28 2021-04-27 Coley Pharmaceutical Group, Inc Vacina compreendendo um ou mais oligonucleotídeo(s) de cpg isolado(s) ou um agonista de tlr e colesterol, e uso da mesma
US10894963B2 (en) 2013-07-25 2021-01-19 Exicure, Inc. Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use
JP6581604B2 (ja) 2014-06-04 2019-09-25 イグジキュア, インコーポレーテッドExicure, Inc. 予防的または治療的適用のためのリポソーム球状核酸による免疫調節物質の多価送達
CN107106493A (zh) 2014-11-21 2017-08-29 西北大学 球形核酸纳米颗粒缀合物的序列特异性细胞摄取
US11364304B2 (en) 2016-08-25 2022-06-21 Northwestern University Crosslinked micellar spherical nucleic acids
US11696954B2 (en) 2017-04-28 2023-07-11 Exicure Operating Company Synthesis of spherical nucleic acids using lipophilic moieties

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996002555A1 (fr) * 1994-07-15 1996-02-01 The University Of Iowa Research Foundation Oligonucleotides immunomodulateurs
WO1998040100A1 (fr) * 1997-03-10 1998-09-17 Ottawa Civic Loeb Research Institute UTILISATION D'ACIDES NUCLEIQUES CONTENANT UN DINUCLEOTIDE CpG NON METHYLE EN TANT QU'ADJUVANT

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Publication number Priority date Publication date Assignee Title
US5866699A (en) * 1994-07-18 1999-02-02 Hybridon, Inc. Oligonucleotides with anti-MDR-1 gene activity
US5908777A (en) * 1995-06-23 1999-06-01 University Of Pittsburgh Lipidic vector for nucleic acid delivery

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996002555A1 (fr) * 1994-07-15 1996-02-01 The University Of Iowa Research Foundation Oligonucleotides immunomodulateurs
WO1998040100A1 (fr) * 1997-03-10 1998-09-17 Ottawa Civic Loeb Research Institute UTILISATION D'ACIDES NUCLEIQUES CONTENANT UN DINUCLEOTIDE CpG NON METHYLE EN TANT QU'ADJUVANT

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
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R.S. CHU ET AL.: "CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity.", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 186, no. 10, 17 November 1997 (1997-11-17), NEW YORK, N.Y., US, pages 1623 - 1631, XP002910130 *

Also Published As

Publication number Publication date
CA2342313A1 (fr) 2000-03-23
NZ510419A (en) 2003-01-31
FR2783170A1 (fr) 2000-03-17
WO2000015256A2 (fr) 2000-03-23
AU5627899A (en) 2000-04-03
AU749282B2 (en) 2002-06-20
FR2783170B1 (fr) 2004-07-16
EP1121148A2 (fr) 2001-08-08
US6610308B1 (en) 2003-08-26

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