WO2000023955A8 - Virus-like particles for the induction of autoantibodies - Google Patents

Virus-like particles for the induction of autoantibodies

Info

Publication number
WO2000023955A8
WO2000023955A8 PCT/US1999/024548 US9924548W WO0023955A8 WO 2000023955 A8 WO2000023955 A8 WO 2000023955A8 US 9924548 W US9924548 W US 9924548W WO 0023955 A8 WO0023955 A8 WO 0023955A8
Authority
WO
WIPO (PCT)
Prior art keywords
particles
virus
methods
autoantibodies
induction
Prior art date
Application number
PCT/US1999/024548
Other languages
French (fr)
Other versions
WO2000023955A1 (en
Inventor
John T Schiller
Bryce Chackerian
Douglas R Lowy
Original Assignee
Us Health
John T Schiller
Bryce Chackerian
Douglas R Lowy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22304219&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2000023955(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to JP2000577627A priority Critical patent/JP4486257B2/en
Priority to AT99970772T priority patent/ATE314095T1/en
Priority to DE69929232T priority patent/DE69929232T2/en
Priority to CA2347411A priority patent/CA2347411C/en
Application filed by Us Health, John T Schiller, Bryce Chackerian, Douglas R Lowy filed Critical Us Health
Priority to EP99970772A priority patent/EP1123114B1/en
Priority to AU12143/00A priority patent/AU770802B2/en
Publication of WO2000023955A1 publication Critical patent/WO2000023955A1/en
Publication of WO2000023955A8 publication Critical patent/WO2000023955A8/en
Priority to US09/835,124 priority patent/US6719978B2/en
Priority to US10/253,443 priority patent/US20030072753A1/en
Priority to US10/867,119 priority patent/US7371572B2/en
Priority to US11/415,611 priority patent/US7479280B2/en
Priority to US12/050,892 priority patent/US7875450B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/084—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/22011—Polyomaviridae, e.g. polyoma, SV40, JC
    • C12N2710/22022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/22011—Polyomaviridae, e.g. polyoma, SV40, JC
    • C12N2710/22023—Virus like particles [VLP]

Abstract

The invention described herein relates to compositions and methods for stimulating immune responses in vivo against a tolerogen. Novel biotechnological tools, pharmaceuticals, therapeutics and prophylactics, which concern chimeric or conjugated virus-like particles, and methods of use the foregoing are provided for the study of B cell tolerance and the treatment or prevention of human diseases, which involve the onset of B cell tolerance, such as chronic viral infection, chronic inflammatory disease, and neoplasia.
PCT/US1999/024548 1998-10-21 1999-10-20 Virus-like particles for the induction of autoantibodies WO2000023955A1 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
AU12143/00A AU770802B2 (en) 1998-10-21 1999-10-20 Virus-like particles for the induction of autoantibodies
EP99970772A EP1123114B1 (en) 1998-10-21 1999-10-20 Virus-like particles for the induction of autoantibodies
AT99970772T ATE314095T1 (en) 1998-10-21 1999-10-20 VIRUS-LIKE PARTICLES FOR INDUCING AUTOANTIBODIES
DE69929232T DE69929232T2 (en) 1998-10-21 1999-10-20 VIRUSELY PARTICLES FOR INDUCING AUTOANTIC BODIES
CA2347411A CA2347411C (en) 1998-10-21 1999-10-20 Virus-like particles for the induction of autoantibodies
JP2000577627A JP4486257B2 (en) 1998-10-21 1999-10-20 Virus-like particles for induction of autoantibodies
US09/835,124 US6719978B2 (en) 1998-10-21 2001-04-13 Virus-like particles for the induction of autoantibodies
US10/253,443 US20030072753A1 (en) 1998-10-21 2002-09-24 Virus-like particles for the induction of autoantibodies
US10/867,119 US7371572B2 (en) 1998-10-21 2004-06-14 Mouse titers after two immunizations with VLPs alone
US11/415,611 US7479280B2 (en) 1998-10-21 2006-05-01 Virus-like particles for the induction of autoantibodies
US12/050,892 US7875450B2 (en) 1998-10-21 2008-03-18 Virus-like particles for the induction of autoantibodies

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10513298P 1998-10-21 1998-10-21
US60/105,132 1998-10-21

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/835,124 Continuation US6719978B2 (en) 1998-10-21 2001-04-13 Virus-like particles for the induction of autoantibodies

Publications (2)

Publication Number Publication Date
WO2000023955A1 WO2000023955A1 (en) 2000-04-27
WO2000023955A8 true WO2000023955A8 (en) 2000-06-22

Family

ID=22304219

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/024548 WO2000023955A1 (en) 1998-10-21 1999-10-20 Virus-like particles for the induction of autoantibodies

Country Status (9)

Country Link
US (5) US6719978B2 (en)
EP (1) EP1123114B1 (en)
JP (1) JP4486257B2 (en)
AT (1) ATE314095T1 (en)
AU (1) AU770802B2 (en)
CA (1) CA2347411C (en)
DE (1) DE69929232T2 (en)
ES (1) ES2258869T3 (en)
WO (1) WO2000023955A1 (en)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5437951A (en) 1992-09-03 1995-08-01 The United States Of America As Represented By The Department Of Health And Human Services Self-assembling recombinant papillomavirus capsid proteins
DE69929232T2 (en) * 1998-10-21 2006-08-31 The United States Government As Represented By The Department Of Health And Human Services VIRUSELY PARTICLES FOR INDUCING AUTOANTIC BODIES
WO2000032227A2 (en) * 1998-11-30 2000-06-08 Cytos Biotechnology Ag Ordered molecular presentation of antigens, method of preparation and use
US7128911B2 (en) 2001-01-19 2006-10-31 Cytos Biotechnology Ag Antigen arrays for treatment of bone disease
US7320793B2 (en) * 2001-01-19 2008-01-22 Cytos Biotechnology Ag Molecular antigen array
US7094409B2 (en) 2001-01-19 2006-08-22 Cytos Biotechnology Ag Antigen arrays for treatment of allergic eosinophilic diseases
AU2007202761B2 (en) * 2001-01-19 2010-01-21 Kuros Biosciences Ag Molecular antigen array
FR2828404B1 (en) * 2001-08-10 2005-07-15 Neovacs COMPOSITE SUPERIMMUNOGEN FOR BIFUNCTIONAL VACCINE USE FOR THE TREATMENT OF DISEASES ASSOCIATED WITH STROMAL TISSUE DISORDER
CN1599623B (en) 2001-09-14 2011-05-11 赛托斯生物技术公司 Packaging of immunostimulatory substances into virus-like particles: method of preparation and use
CN1558774B (en) * 2001-10-05 2012-03-14 赛托斯生物技术公司 Angiotensin peptide-carrier conjugates and uses thereof
MXPA04002644A (en) 2001-10-05 2004-07-08 Cytos Biotechnology Ag Angiotensin peptide-carrier conjugates and uses thereof.
US7115266B2 (en) 2001-10-05 2006-10-03 Cytos Biotechnology Ag Angiotensin peptide-carrier conjugates and uses thereof
RU2319503C2 (en) * 2001-11-07 2008-03-20 Цитос Байотекнолоджи Аг Composition for immunization (variants), method for its preparing and using for treatment of allergic eosinophilic diseases
NZ532515A (en) * 2001-11-07 2005-10-28 Cytos Biotechnology Ag Compositions comprising a RANKL peptide attached to a core or virus-like particle for treatment of bone disease and immunization
CN1321695C (en) * 2001-11-07 2007-06-20 赛托斯生物技术公司 Antigen arrays presenting il-5, il-13 or eotaxin for treatment of allergic eosinophilic diseases
JP4658475B2 (en) * 2001-11-07 2011-03-23 サイトス バイオテクノロジー アーゲー Antigen array for bone disease treatment
US20030219459A1 (en) * 2002-01-18 2003-11-27 Cytos Biotechnology Ag Prion protein carrier-conjugates
US7285289B2 (en) 2002-04-12 2007-10-23 Nagy Jon O Nanoparticle vaccines
US9045727B2 (en) * 2002-05-17 2015-06-02 Emory University Virus-like particles, methods of preparation, and immunogenic compositions
WO2004042001A2 (en) * 2002-05-17 2004-05-21 Emory University Virus-like particles, methods of preparation, and immonogenic compositions
CA2486118A1 (en) * 2002-06-07 2003-12-18 Large Scale Biology Corporation Flexible vaccine assembly and vaccine delivery platform
CA2489410C (en) 2002-07-17 2015-01-13 Cytos Biotechnology Ag Molecular antigen arrays
KR20120041739A (en) 2002-07-18 2012-05-02 사이토스 바이오테크놀로지 아게 Hapten-carrier conjugates and uses thereof
DE60336902D1 (en) * 2002-07-19 2011-06-09 Cytos Biotechnology Ag VACCINE COMPOSITIONS CONTAINING AMYLOID BETA 1-6 ANTIGENARRAYS
WO2004032622A2 (en) * 2002-09-03 2004-04-22 Large Scale Biology Corporation Production of peptides in plants as viral coat protein fusions
WO2004085635A1 (en) 2003-03-26 2004-10-07 Cytos Biotechnology Ag Melan-a peptide analogue-virus-like-particle conjugates
US7537767B2 (en) 2003-03-26 2009-05-26 Cytis Biotechnology Ag Melan-A- carrier conjugates
US20060210588A1 (en) * 2003-03-26 2006-09-21 Cytos Biotechnology Ag Hiv-peptide-carrier-conjugates
WO2005005614A2 (en) * 2003-07-03 2005-01-20 Pecos Labs, Inc. Combined b-cell and t-cell epitopes on vlp for improved vaccines
CN1905903A (en) * 2004-01-20 2007-01-31 赛托斯生物技术公司 Ghrelin-carrier conjugates
WO2005091753A2 (en) * 2004-03-25 2005-10-06 Large Scale Biology Corporation Flexible vaccine assembly and vaccine delivery platform
US20090053261A1 (en) * 2005-09-08 2009-02-26 Lindbo John A Modified tobacco mosaic virus particles as scaffolds for display of protein antigens for vaccine applications
WO2005117983A2 (en) * 2004-06-02 2005-12-15 Cytos Biotechnology Ag Carrier conjugates of tnf-peptides
KR20070058426A (en) * 2004-06-02 2007-06-08 사이토스 바이오테크놀로지 아게 Medical uses of carrier conjugates of non-human tnf-peptides
DE102004036913A1 (en) * 2004-07-16 2006-02-09 Responsif Gmbh Use of pentamers for the manufacture of a medicament
EP1812051A2 (en) 2004-10-05 2007-08-01 Cytos Biotechnology AG Vlp-antigen conjugates and their uses as vaccines
CN101119749A (en) 2004-10-25 2008-02-06 赛托斯生物技术公司 Gastric inhibitory polypeptide (gip) antigen arrays and uses thereof
GB0424563D0 (en) 2004-11-05 2004-12-08 Novartis Ag Organic compounds
PL1868642T3 (en) * 2005-03-18 2013-10-31 Cytos Biotechnology Ag Cat allergen fusion proteins and uses thereof
LT5414B (en) * 2005-04-13 2007-04-25 Biotechnologijos Institutas Process for preparing monoclonal antibodies; hybridoma cell lines generated by this process and recombinant chimeric virus-like particles with inserted foreign protein fragments as immunogenes to generate hybridomas by this process
RU2007147938A (en) * 2005-06-14 2009-07-20 Цитос Биотехнологи Аг (Ch) ANTIGEN CONJUGATES AND THEIR APPLICATION
ES2310062B1 (en) * 2005-07-15 2009-11-13 Bionostra, S.L. PSEUDOVIRAL PARTICLES CHEMICAL EMPTY DERIVED FROM VIRUS CAUSING INFECTIOUS BURSITIS DISEASE (IBDV), PROCEDURE OF OBTAINING AND APPLICATIONS.
ZA200802225B (en) 2005-09-28 2009-10-28 Cytos Biotechnology Ag Interleukin-1 conjugates and uses thereof
EP1973608A1 (en) 2005-12-14 2008-10-01 Cytos Biotechnology AG Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity
DK2032592T3 (en) 2006-06-12 2013-09-02 Cytos Biotechnology Ag PROCEDURES FOR PACKING OLIGONUCLEOTIDES FOR VIRUS LIKE PARTICLES OF RNA BACTERY PHAGES
CN101611048B (en) 2006-12-12 2012-11-07 赛托斯生物技术公司 Oligonucleotides containing high concentrations of guanine monomers
WO2008145400A2 (en) * 2007-05-31 2008-12-04 Medigene Ag Mutated structural protein of a parvovirus
EP2012122A1 (en) 2007-07-06 2009-01-07 Medigene AG Mutated parvovirus structural proteins as vaccines
US20090011996A1 (en) * 2007-07-06 2009-01-08 University Of Louisville Research Foundation, Inc. Diagnosing and protecting horses against papillomavirus
EP2062592A1 (en) 2007-11-20 2009-05-27 BUNDESREPUBLIK DEUTSCHLAND letztvertreten durch das Robert Koch-Institut vertreten durch seinen Präsidenten System for delivery into a XCR1 positive cell and uses thereof
AU2009325950B2 (en) 2008-12-09 2013-03-07 Pfizer Vaccines Llc IgE CH3 peptide vaccine
RU2518291C2 (en) 2009-07-30 2014-06-10 Пфайзер Вэксинс ЭлЭлСи Antigen tau-peptides and their application
CA2771770A1 (en) 2009-09-03 2011-03-10 Pfizer Vaccines Llc Pcsk9 vaccine
US9301997B2 (en) 2009-09-21 2016-04-05 Peptinov Sas Method of vaccination for limiting articular inflammation in rheumatoid arthritis and multiple sclerosis by administering IL-23 peptides
CA2800774A1 (en) 2010-06-07 2011-12-15 Pfizer Vaccines Llc Ige ch3 peptide vaccine
EP2755677B1 (en) * 2011-09-15 2020-11-04 Medigene AG Anti-her2 vaccine based upon aav derived multimeric structures
CA2936092A1 (en) 2013-01-23 2014-07-31 The Board Of Trustees Of The Leland Stanford Junior University Stabilized hepatitis b core polypeptide
WO2015017280A1 (en) 2013-07-28 2015-02-05 Qantu Therapeutics, Inc. Vaccine formulations that induce a th2 immune response
WO2015123291A1 (en) 2014-02-11 2015-08-20 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Pcsk9 vaccine and methods of using the same
WO2017071713A1 (en) 2015-10-30 2017-05-04 University Of Copenhagen Virus like particle with efficient epitope display
CA3155202A1 (en) 2019-10-23 2021-04-29 Arthur M. Krieg Synthetic rig-i-like receptor agonists
WO2022140655A1 (en) * 2020-12-23 2022-06-30 The Trustees Of Columbia University In The City Of New York Single-molecule electronic multiplex nanopore immunoassays for biomarker detection
WO2023235410A2 (en) * 2022-06-01 2023-12-07 The Regents Of The University Of California Multivalent display of apoai peptide on nanoparticles against atherosclerosis

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143726A (en) 1986-12-09 1992-09-01 The Scripps Research Institute T cell epitopes of the hepatitis B virus nucleocapsid protein
GB8903313D0 (en) 1989-02-14 1989-04-05 Wellcome Found Conjugates
US5714374A (en) * 1990-09-12 1998-02-03 Rutgers University Chimeric rhinoviruses
GB9114003D0 (en) 1991-06-28 1991-08-14 Mastico Robert A Chimaeric protein
JPH0519914A (en) * 1991-07-17 1993-01-29 Sharp Corp Inside voltage drop circuit for semiconductor device
KR940008286B1 (en) * 1991-08-19 1994-09-09 삼성전자 주식회사 Internal voltage-source generating circuit
CH684782A5 (en) 1992-01-27 1994-12-30 Rolf M Zinkernagel C O Inst Fu Antigen for inducing CD8+ cellular immune responses
KR950008453B1 (en) * 1992-03-31 1995-07-31 삼성전자주식회사 Internal source voltage generating circuit
US5437951A (en) 1992-09-03 1995-08-01 The United States Of America As Represented By The Department Of Health And Human Services Self-assembling recombinant papillomavirus capsid proteins
US5618536A (en) 1992-09-03 1997-04-08 The United States Of America As Represented By The Department Of Health And Human Services Chimeric papillomavirus-like particles
WO1994006920A1 (en) 1992-09-22 1994-03-31 Medical Research Council Recombinant viruses displaying a nonviral polypeptide on their external surface
DK96493D0 (en) 1993-08-26 1993-08-26 Mouritsen Og Elsner Aps PROCEDURE FOR INDUCING ANTIBODY RESPONSE TO SELF-PROTEINS AND AUTOVACCINE PROCESSED BY THE PROCEDURE
US5721485A (en) * 1996-01-04 1998-02-24 Ibm Corporation High performance on-chip voltage regulator designs
AU2678097A (en) 1996-04-16 1997-11-07 Immusol Incorporated Targeted viral vectors
KR100224669B1 (en) * 1996-12-10 1999-10-15 윤종용 Internal voltage generator circuit
US6171591B1 (en) * 1997-12-08 2001-01-09 Pentamer Pharmaceuticals, Inc. Recombinant nodavirus compositions and methods
JPH11231954A (en) * 1998-02-16 1999-08-27 Mitsubishi Electric Corp Internal power supply voltage generation circuit
DE19827457C1 (en) 1998-06-19 2000-03-02 Medigene Ag Structural protein of AAV, its production and use
EP0994403B1 (en) * 1998-10-15 2003-05-21 Lucent Technologies Inc. Current mirror
DE69929232T2 (en) 1998-10-21 2006-08-31 The United States Government As Represented By The Department Of Health And Human Services VIRUSELY PARTICLES FOR INDUCING AUTOANTIC BODIES
WO2000032227A2 (en) 1998-11-30 2000-06-08 Cytos Biotechnology Ag Ordered molecular presentation of antigens, method of preparation and use
US6373754B1 (en) * 2000-07-17 2002-04-16 Samsung Electronics Co., Ltd. Semiconductor memory device having stable internal supply voltage driver
US20060210687A1 (en) * 2002-11-06 2006-09-21 Fiberstar, Inc. Enhanced crackers, chips, wafers and unleavened using highly refined cellulose fiber ingredients

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