WO2000025925A1 - Zuführsystem für geschlossene reaktionskammern mit beweglichen probenracks - Google Patents
Zuführsystem für geschlossene reaktionskammern mit beweglichen probenracks Download PDFInfo
- Publication number
- WO2000025925A1 WO2000025925A1 PCT/CH1999/000516 CH9900516W WO0025925A1 WO 2000025925 A1 WO2000025925 A1 WO 2000025925A1 CH 9900516 W CH9900516 W CH 9900516W WO 0025925 A1 WO0025925 A1 WO 0025925A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- vessels
- adapter plate
- sample
- feed system
- reaction chambers
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00281—Individual reactor vessels
- B01J2219/00283—Reactor vessels with top opening
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00308—Reactor vessels in a multiple arrangement interchangeably mounted in racks or blocks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00364—Pipettes
- B01J2219/00367—Pipettes capillary
- B01J2219/00369—Pipettes capillary in multiple or parallel arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00373—Hollow needles
- B01J2219/00376—Hollow needles in multiple or parallel arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00479—Means for mixing reactants or products in the reaction vessels
- B01J2219/00484—Means for mixing reactants or products in the reaction vessels by shaking, vibrating or oscillating of the reaction vessels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00495—Means for heating or cooling the reaction vessels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00585—Parallel processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4022—Concentrating samples by thermal techniques; Phase changes
- G01N2001/4027—Concentrating samples by thermal techniques; Phase changes evaporation leaving a concentrated sample
Definitions
- the invention relates to a system for supplying gaseous or liquid media into the interior of sample or reaction vessels, which are moved in vacuum centrifuges or in reaction chambers with integrated shakers, in which several liquid samples are processed simultaneously.
- the samples are usually in test tubes or racks with corresponding wells. Since these vessels are very narrow, i.e. the ratio of the vessel depth to the vessel diameter is very large, the following problem arises: the cooling of the sample due to the evaporation results in a cold plug in the vessel and thus largely prevents the vapor phase from being sucked out of the sample vessels.
- a device is known from PCT / CH 97/00431 and from vacuum centrifuges in which the sample vessels are positioned in preheated or heated racks. Since the cooling by the evaporation energy can only be compensated very poorly by heating or IR radiation, and the vessels mostly consist of well insulated material, such as glass or plastic, extremely lengthy processes have to be accepted for certain applications.
- the invention has for its object to provide a system with which the mentioned disadvantages of the prior art are eliminated. According to the invention, this is achieved by means of a supply system of the type mentioned at the outset, which is characterized in that an adapter plate with the individual vessels, arranged in a grid pattern, is arranged above the sample vessels within the reaction chamber or the vacuum centrifuge and has a feed line for the gaseous or liquid Medium is provided and the height is adjustable so that the cannulas can be inserted into the sample vessels at any depth.
- warm gas or liquid can be introduced into the moving sample vessels to prevent the formation of a cold plug in the sample vessel during the evaporation process and to allow reagents to be fed into the individual sample vessels at the same time.
- the adapter plate and the sample rack or, in the case of the centrifuge, the rotor are coupled to one another so that the positioning of the cannula in the corresponding sample vessel remains unchanged when shaken or centrifuged.
- the adapter plate can preferably be heated so that the medium can flow preheated into the sample vessels.
- the preferably inert gas flow is reduced in such a way that at least the formation of a cold plug in the sample vessel is prevented.
- a reaction chamber 1 is closed from above with a glass plate 2.
- a shaking plate 3 on which a sample rack 4 with sample vessels 5 is positioned.
- An adapter plate 6 with cannulas 7 is positioned above the sample rack 4 and fixed to guide pins 8 which are firmly connected to the shaking plate.
- the adapter plate 6 thus moves synchronously with the shaking plate 3 and the sample rack 4.
- a gas introduction system 9 and a flexible transfer line '13 gas flows through a heat exchanger 12 in the adapter plate 6 which by means of above the glass plate of the chamber arranged infrared lamps 10 outside heated can.
- the gas flows through the adapter plate 6, heats up and flows through the cannulas 7 into the sample vessels 5.
- the gas or vapors are sucked out of the reaction chamber 1 via the vacuum pump system 11.
- Glass, metal or plastic capillaries are suitable as cannulas or, in the case of centrifuges with swinging sample vessels, flexible fused silica, Teflon or plastic capillaries.
- the gas introduction system is connected in the center of the adapter plate by means of sealing systems known per se.
- the gas inlet system, the vacuum pump system and the reaction chamber with heat radiators are known per se in the relevant prior art and therefore do not need to be described in more detail here.
- the gassing can also be carried out in the overpressure range with appropriate adaptations to the apparatus.
- the reaction chamber and the gas inlet system are designed in accordance with the corresponding prior art for the required pressure range.
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU64574/99A AU6457499A (en) | 1998-11-03 | 1999-11-03 | Feed system for closed reaction chambers with moveable sample racks |
JP2000579355A JP4597375B2 (ja) | 1998-11-03 | 1999-11-03 | 可動試料棚を有する閉鎖反応室への供給システム |
AT99952204T ATE245490T1 (de) | 1998-11-03 | 1999-11-03 | Vakuumzentrifuge bzw. reaktionskammer |
EP99952204A EP1126918B1 (de) | 1998-11-03 | 1999-11-03 | Vakuumzentrifuge bzw. Reaktionskammer |
DE59906386T DE59906386D1 (de) | 1998-11-03 | 1999-11-03 | Vakuumzentrifuge bzw. Reaktionskammer |
US09/830,943 US6482363B1 (en) | 1998-11-03 | 1999-11-03 | Feed system for closed reaction chambers with moveable sample racks |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH2214/98 | 1998-11-03 | ||
CH221498 | 1998-11-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2000025925A1 true WO2000025925A1 (de) | 2000-05-11 |
Family
ID=4228533
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CH1999/000516 WO2000025925A1 (de) | 1998-11-03 | 1999-11-03 | Zuführsystem für geschlossene reaktionskammern mit beweglichen probenracks |
Country Status (7)
Country | Link |
---|---|
US (1) | US6482363B1 (de) |
EP (1) | EP1126918B1 (de) |
JP (1) | JP4597375B2 (de) |
AT (1) | ATE245490T1 (de) |
AU (1) | AU6457499A (de) |
DE (1) | DE59906386D1 (de) |
WO (1) | WO2000025925A1 (de) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002081076A2 (en) * | 2001-04-05 | 2002-10-17 | Symyx Technologies, Inc. | A combinatorial chemistry reactor system |
WO2004008154A1 (de) * | 2002-07-16 | 2004-01-22 | H+P Labortechnik Ag | Probenbehandlungsstation |
DE102005054206B4 (de) * | 2005-11-14 | 2010-07-15 | Roth, Willi, Prof. Dr. | Verfahren und Vorrichtung zum automatisierten Bearbeiten von gepoolten Proben |
EP3002056A1 (de) * | 2014-10-03 | 2016-04-06 | CTC Analytics AG | Mischvorrichtung zum Durchmischen einer Probe während eines SPME-Verfahren |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6787112B1 (en) | 1998-08-13 | 2004-09-07 | Symyx Technologies, Inc. | Parallel reactor with internal sensing and method of using same |
FR2812088B1 (fr) * | 2000-07-21 | 2003-01-24 | Abx Sa | Dispositif de traitement d'echantillons de produits sanguins |
EP1501555B1 (de) * | 2002-04-26 | 2007-02-21 | Gambro, Inc., | Vorrichtung zur bestrahlung und mischung von fluiden in behältern |
DE102006030056B3 (de) * | 2006-06-29 | 2007-06-21 | Ika - Werke Gmbh & Co. Kg | Mikrotiterplatte mit Rührelementen |
US7883265B2 (en) * | 2007-06-01 | 2011-02-08 | Applied Biosystems, Llc | Devices, systems, and methods for preparing emulsions |
DE112014005095A5 (de) | 2013-11-08 | 2016-09-01 | Schaeffler Technologies AG & Co. KG | Fluidanordnung |
WO2020223284A1 (en) | 2019-04-29 | 2020-11-05 | Ankom Technology Corporation | Systems and methods for extracting analytes from a sample |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0210014A2 (de) * | 1985-07-05 | 1987-01-28 | Cetus Corporation | Automatisiertes Flüssigkeitsbehandlungsgerät und Verfahren mit Plattenbehandlungsgerät |
WO1990002605A1 (en) * | 1988-09-02 | 1990-03-22 | Meldal Morten | An apparatus and a method for the synthesis of peptides |
WO1998020965A1 (de) * | 1996-11-13 | 1998-05-22 | Doebelin Werner | Reaktionskammersystem für die chemische synthese oder verwandte anwendungen |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3167259A (en) * | 1961-03-08 | 1965-01-26 | Arthur H Pitchford | Method and apparatus for grinding and/or blending |
US4058146A (en) * | 1975-07-11 | 1977-11-15 | Dynatech Laboratories Incorporated | Method and apparatus for transferring liquid |
US5055263A (en) * | 1988-01-14 | 1991-10-08 | Cyberlab, Inc. | Automated pipetting system |
US5069972A (en) | 1988-09-12 | 1991-12-03 | Versic Ronald J | Moldable microcapsule that contains a high percentage of solid core material, and method of manufacture thereof |
US5132088A (en) * | 1988-11-17 | 1992-07-21 | Kabushiki Kaisha Nittec | Automatic medical sampling device |
JPH0487733U (de) * | 1990-09-03 | 1992-07-30 | ||
US6274094B1 (en) * | 1997-01-13 | 2001-08-14 | Weller, Iii Harold Norris | Nestable, modular apparatus for synthesis of multiple organic compounds |
DE59802862D1 (de) * | 1997-11-08 | 2002-02-28 | Chemspeed Ltd | Vorrichtung zur halterung von temperier- und schüttelbaren reaktionsgefässen |
JP3326108B2 (ja) * | 1998-05-22 | 2002-09-17 | 株式会社モリテックス | ガス吹付式濃縮装置 |
-
1999
- 1999-11-03 US US09/830,943 patent/US6482363B1/en not_active Expired - Lifetime
- 1999-11-03 JP JP2000579355A patent/JP4597375B2/ja not_active Expired - Fee Related
- 1999-11-03 AT AT99952204T patent/ATE245490T1/de active
- 1999-11-03 DE DE59906386T patent/DE59906386D1/de not_active Expired - Lifetime
- 1999-11-03 WO PCT/CH1999/000516 patent/WO2000025925A1/de active IP Right Grant
- 1999-11-03 AU AU64574/99A patent/AU6457499A/en not_active Abandoned
- 1999-11-03 EP EP99952204A patent/EP1126918B1/de not_active Expired - Lifetime
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0210014A2 (de) * | 1985-07-05 | 1987-01-28 | Cetus Corporation | Automatisiertes Flüssigkeitsbehandlungsgerät und Verfahren mit Plattenbehandlungsgerät |
WO1990002605A1 (en) * | 1988-09-02 | 1990-03-22 | Meldal Morten | An apparatus and a method for the synthesis of peptides |
WO1998020965A1 (de) * | 1996-11-13 | 1998-05-22 | Doebelin Werner | Reaktionskammersystem für die chemische synthese oder verwandte anwendungen |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002081076A2 (en) * | 2001-04-05 | 2002-10-17 | Symyx Technologies, Inc. | A combinatorial chemistry reactor system |
WO2002081076A3 (en) * | 2001-04-05 | 2003-04-24 | Symyx Technologies Inc | A combinatorial chemistry reactor system |
US6692708B2 (en) | 2001-04-05 | 2004-02-17 | Symyx Technologies, Inc. | Parallel reactor for sampling and conducting in situ flow-through reactions and a method of using same |
US7045358B2 (en) | 2001-04-05 | 2006-05-16 | Symyx Technologies, Inc. | Parallel reactor for sampling and conducting in situ flow-through reactions and a method of using same |
WO2004008154A1 (de) * | 2002-07-16 | 2004-01-22 | H+P Labortechnik Ag | Probenbehandlungsstation |
DE10232202A1 (de) * | 2002-07-16 | 2004-02-05 | Herz, Helmut, Dr.-Ing. | Probenbehandlungsstation |
DE10232202B4 (de) * | 2002-07-16 | 2005-08-25 | H+P Labortechnik Ag | Probenbehandlungsstation |
DE102005054206B4 (de) * | 2005-11-14 | 2010-07-15 | Roth, Willi, Prof. Dr. | Verfahren und Vorrichtung zum automatisierten Bearbeiten von gepoolten Proben |
EP3002056A1 (de) * | 2014-10-03 | 2016-04-06 | CTC Analytics AG | Mischvorrichtung zum Durchmischen einer Probe während eines SPME-Verfahren |
Also Published As
Publication number | Publication date |
---|---|
ATE245490T1 (de) | 2003-08-15 |
JP4597375B2 (ja) | 2010-12-15 |
JP2002528266A (ja) | 2002-09-03 |
EP1126918A1 (de) | 2001-08-29 |
DE59906386D1 (de) | 2003-08-28 |
AU6457499A (en) | 2000-05-22 |
US6482363B1 (en) | 2002-11-19 |
EP1126918B1 (de) | 2003-07-23 |
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