WO2000026244A3 - A novel tumor necrosis factor family member, drl, and related compositions and methods - Google Patents

A novel tumor necrosis factor family member, drl, and related compositions and methods Download PDF

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Publication number
WO2000026244A3
WO2000026244A3 PCT/US1999/025954 US9925954W WO0026244A3 WO 2000026244 A3 WO2000026244 A3 WO 2000026244A3 US 9925954 W US9925954 W US 9925954W WO 0026244 A3 WO0026244 A3 WO 0026244A3
Authority
WO
WIPO (PCT)
Prior art keywords
drl
seq
set forth
provides
methods
Prior art date
Application number
PCT/US1999/025954
Other languages
French (fr)
Other versions
WO2000026244A2 (en
Inventor
Michael J Lenardo
Jin Wang
Di Jiang
Original Assignee
Us Gov Health & Human Serv
Michael J Lenardo
Jin Wang
Di Jiang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv, Michael J Lenardo, Jin Wang, Di Jiang filed Critical Us Gov Health & Human Serv
Priority to AU14670/00A priority Critical patent/AU1467000A/en
Publication of WO2000026244A2 publication Critical patent/WO2000026244A2/en
Publication of WO2000026244A3 publication Critical patent/WO2000026244A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The present invention provides an isolated nucleic acids encoding DRL proteins, DRL-1 and DRL-2, as set forth in the Sequence Listing as SEQ ID NO:1 and SEQ ID NO:3, respectively. The invention also provides a unique fragment of SEQ ID NO:1 that encodes amino acid residues 65 to 250 of DRL-1 as set forth in SEQ ID NO:2. The invention further provides purified polypeptides encoded by the nucleic acids encoding the DRL proteins as set forth in SEQ ID NO:1 and SEQ ID NO:3, purified polypeptide having the sequences set forth in the sequence listing as SEQ ID NO:2, SEQ ID NO:4 and SEQ ID NO:6 and of DRL polypeptides which can be used to stimulate an immune response or induce apoptosis. In another aspect the invention provides purified antibodies which bind to the DRL protein or fragments thereof. These antibodies can be used to inhibit a T cell response, to inhibit apoptosis or to suppress an autoimmune response.
PCT/US1999/025954 1998-11-04 1999-11-04 A novel tumor necrosis factor family member, drl, and related compositions and methods WO2000026244A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU14670/00A AU1467000A (en) 1998-11-04 1999-11-04 A novel tumor necrosis factor family member, drl, and related compositions and methods

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10697698P 1998-11-04 1998-11-04
US60/106,976 1998-11-04

Publications (2)

Publication Number Publication Date
WO2000026244A2 WO2000026244A2 (en) 2000-05-11
WO2000026244A3 true WO2000026244A3 (en) 2000-11-09

Family

ID=22314220

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/025954 WO2000026244A2 (en) 1998-11-04 1999-11-04 A novel tumor necrosis factor family member, drl, and related compositions and methods

Country Status (2)

Country Link
AU (1) AU1467000A (en)
WO (1) WO2000026244A2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6541224B2 (en) 1996-03-14 2003-04-01 Human Genome Sciences, Inc. Tumor necrosis factor delta polypeptides
US7217788B2 (en) 1996-03-14 2007-05-15 Human Genome Sciences, Inc. Human tumor necrosis factor delta polypeptides
US6689579B1 (en) 1996-10-25 2004-02-10 Human Genome Sciences, Inc. Polynucleotides encoding neutrokine-α
US6812327B1 (en) 1996-10-25 2004-11-02 Human Genome Sciences, Inc. Neutrokine-alpha polypeptides
PL198934B1 (en) 1999-01-25 2008-08-29 Apoxis Sa Baff, related blocking agents and their use in the stimulation and inhibition of b-cells and immunoglobulins in immune responses
US20030095967A1 (en) 1999-01-25 2003-05-22 Mackay Fabienne BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders
DK1210425T4 (en) 1999-08-17 2015-08-10 Apotech R & D Sa BAFF receptor (BCMA), an immunoregulatory agent
UA74798C2 (en) 1999-10-06 2006-02-15 Байоджен Айдек Ма Інк. Method for treating cancer in mammals using polypeptide interfering with interaction between april and its receptors
US7220840B2 (en) 2000-06-16 2007-05-22 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to B lymphocyte stimulator protein
PT2275449T (en) 2000-06-16 2016-12-27 Human Genome Sciences Inc Antibodies that immunospecifically bind to blys
US20030091565A1 (en) 2000-08-18 2003-05-15 Beltzer James P. Binding polypeptides and methods based thereon
DE10045591A1 (en) * 2000-09-15 2002-04-04 Klaus Pfizenmaier Site-specific, antibody-mediated activation of proapoptotic cytokines - AMAIZe (Antibody-Mediated Apoptosis Inducing Cytokines)
UA83458C2 (en) 2000-09-18 2008-07-25 Байоджен Айдек Ма Інк. The isolated polypeptide baff-r (the receptor of the factor of activation of b-cells of the family tnf)
CA2446734A1 (en) 2001-05-24 2002-11-28 Human Genome Sciences, Inc. Antibodies against tumor necrosis factor delta (april)
US7700317B2 (en) 2003-03-28 2010-04-20 Biogen Idec Ma Inc. Truncated baff receptors
US20050186577A1 (en) 2004-02-20 2005-08-25 Yixin Wang Breast cancer prognostics
WO2006044582A2 (en) 2004-10-13 2006-04-27 The Washington University Use of baff to treat sepsis
US9168286B2 (en) 2005-10-13 2015-10-27 Human Genome Sciences, Inc. Methods and compositions for use in treatment of patients with autoantibody positive disease
CA2629306A1 (en) 2005-11-23 2007-05-31 Genentech, Inc. Methods and compositions related to b cell assays
WO2007123765A2 (en) 2006-03-31 2007-11-01 Human Genome Sciences Inc. Neutrokine-alpha and neutrokine-alpha splice variant

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994019463A2 (en) * 1993-02-16 1994-09-01 Auckland Uniservices Limited Developmental tyrosine kinases and their ligands
WO1997033902A1 (en) * 1996-03-14 1997-09-18 Human Genome Sciences, Inc. Human tumor necrosis factor delta and epsilon
EP0869180A1 (en) * 1997-04-02 1998-10-07 Smithkline Beecham Corporation A TNF homologue, TL5
WO1998055621A1 (en) * 1997-06-06 1998-12-10 Regeneron Pharmaceuticals, Inc. Ntn-2 member of tnf ligand family
WO1998055620A1 (en) * 1997-06-06 1998-12-10 Regeneron Pharmaceuticals, Inc. Ntn-2 member of tnf ligand family
WO1999011791A2 (en) * 1997-09-05 1999-03-11 University Of Washington Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents
EP0919620A2 (en) * 1997-11-26 1999-06-02 Eli Lilly And Company TRAILLK-3: a member of the TNF ligand family
WO1999028462A2 (en) * 1997-12-03 1999-06-10 Genentech, Inc. Polypeptides and nucleic acids encoding the same

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994019463A2 (en) * 1993-02-16 1994-09-01 Auckland Uniservices Limited Developmental tyrosine kinases and their ligands
WO1997033902A1 (en) * 1996-03-14 1997-09-18 Human Genome Sciences, Inc. Human tumor necrosis factor delta and epsilon
EP0869180A1 (en) * 1997-04-02 1998-10-07 Smithkline Beecham Corporation A TNF homologue, TL5
WO1998055621A1 (en) * 1997-06-06 1998-12-10 Regeneron Pharmaceuticals, Inc. Ntn-2 member of tnf ligand family
WO1998055620A1 (en) * 1997-06-06 1998-12-10 Regeneron Pharmaceuticals, Inc. Ntn-2 member of tnf ligand family
WO1999011791A2 (en) * 1997-09-05 1999-03-11 University Of Washington Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents
EP0919620A2 (en) * 1997-11-26 1999-06-02 Eli Lilly And Company TRAILLK-3: a member of the TNF ligand family
WO1999028462A2 (en) * 1997-12-03 1999-06-10 Genentech, Inc. Polypeptides and nucleic acids encoding the same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HAHNE M ET AL: "APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth", JOURNAL OF EXPERIMENTAL MEDICINE,JP,TOKYO, vol. 188, no. 6, 21 September 1998 (1998-09-21), pages 1185 - 1190-1190, XP002099001, ISSN: 0022-1007 *

Also Published As

Publication number Publication date
AU1467000A (en) 2000-05-22
WO2000026244A2 (en) 2000-05-11

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