WO2000036976A1 - Detector - Google Patents

Detector Download PDF

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Publication number
WO2000036976A1
WO2000036976A1 PCT/GB1999/004340 GB9904340W WO0036976A1 WO 2000036976 A1 WO2000036976 A1 WO 2000036976A1 GB 9904340 W GB9904340 W GB 9904340W WO 0036976 A1 WO0036976 A1 WO 0036976A1
Authority
WO
WIPO (PCT)
Prior art keywords
breath
temperature
exhaled breath
detecting
operable
Prior art date
Application number
PCT/GB1999/004340
Other languages
French (fr)
Inventor
Peter Barnes
Sergei Kharitonov
Original Assignee
Boditech Diagnostics Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boditech Diagnostics Limited filed Critical Boditech Diagnostics Limited
Priority to AU18753/00A priority Critical patent/AU1875300A/en
Publication of WO2000036976A1 publication Critical patent/WO2000036976A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/411—Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption

Definitions

  • This invention relates to detectors.
  • nitric oxide (NO) content which can indicate a level of lung inflammation due to allergen challenge.
  • This invention provides apparatus for detecting the temperature of exhaled breath along with the level of at least one gaseous component of the exhaled breath.
  • the at least one gaseous component is NO, carbon monoxide (CO), or both.
  • the time dependence of the detected temperature and gas component levels are detected and/or analysed during at least a part of the duration of exhalation of a breath.
  • any results obtained with reference to an initial portion of the breath are discarded or disregarded.
  • a flow rate of the exhaled breath is also detected; this information can in part be used to calibrate one or more of the other measurements.
  • FIG. 1 schematically illustrates a sampling system.
  • a tube 10 having a disposable mouthpiece 20 (for hygiene) has a temperature probe 30 supported at or near to the mouthpiece end of the tube (although it could be elsewhere in the air flow path).
  • the probe 30, for example a thermocouple is connected to temperature detection circuitry 40.
  • a tube 50 taps off a proportion of the air exhaled into the mouthpiece and communicates with a detection apparatus 60 for NO & CO.
  • Further tubes 70 (and there may be more) are used in conjunction with a flow rate detector 80 to detect rate of flow through the tube 10.
  • a restriction 90 imposes a back pressure against the exhalation, assisting in the proper detection of NO.
  • results relating to a first part of the breath can be disregarded or discarded.
  • Figure 2 illustrates some preliminary results obtained for temperature measurement. Asthma sufferers are found to have a more rapid temperature rise time than "normal" patients. Kartaghemer syndrome sufferers have a slower rise time but a higher asymptotic temperature. These results can be correlated with the detected NO & CO levels to provide a more accurate diagnostic detection of these or other medical problems or situations.

Abstract

Diagnostic apparatus comprises means (30) for detecting the temperature of exhaled breath along with the concentration of at least one gaseous component of the exhaled breath.

Description

DETECTOR
This invention relates to detectors.
It has been proposed to measure the level of gaseous components of exhaled breath, for example as a diagnostic tool. An example is a measurement of nitric oxide (NO) content, which can indicate a level of lung inflammation due to allergen challenge.
This invention provides apparatus for detecting the temperature of exhaled breath along with the level of at least one gaseous component of the exhaled breath. Preferably the at least one gaseous component is NO, carbon monoxide (CO), or both.
Preferably the time dependence of the detected temperature and gas component levels are detected and/or analysed during at least a part of the duration of exhalation of a breath. Preferably any results obtained with reference to an initial portion of the breath are discarded or disregarded. Preferably a flow rate of the exhaled breath is also detected; this information can in part be used to calibrate one or more of the other measurements.
An embodiment will now be described by way of example only. Figure 1 schematically illustrates a sampling system. A tube 10 having a disposable mouthpiece 20 (for hygiene) has a temperature probe 30 supported at or near to the mouthpiece end of the tube (although it could be elsewhere in the air flow path). The probe 30, for example a thermocouple, is connected to temperature detection circuitry 40. A tube 50 taps off a proportion of the air exhaled into the mouthpiece and communicates with a detection apparatus 60 for NO & CO. Further tubes 70 (and there may be more) are used in conjunction with a flow rate detector 80 to detect rate of flow through the tube 10.
A restriction 90 imposes a back pressure against the exhalation, assisting in the proper detection of NO.
To avoid problems with so-called "dead space" air, results relating to a first part of the breath (e.g. the first 5 seconds or the first 250 ml) can be disregarded or discarded.
Figure 2 illustrates some preliminary results obtained for temperature measurement. Asthma sufferers are found to have a more rapid temperature rise time than "normal" patients. Kartaghemer syndrome sufferers have a slower rise time but a higher asymptotic temperature. These results can be correlated with the detected NO & CO levels to provide a more accurate diagnostic detection of these or other medical problems or situations.

Claims

1. Diagnostic apparatus comprising means for detecting the temperature of exhaled breath along with the concentration of at least one gaseous component of the exhaled breath.
2. Apparatus according to claim 1, in which the at least one gaseous component is NO, carbon monoxide (CO), or both.
3. Apparatus according to claim 1 or claim 2, in which the detecting means is operable to detect the variation with time of the detected temperature and gas component levels during at least a part of the duration of exhalation of a breath.
4. Apparatus according to any one of the preceding claims, in which the detecting means is operable to discard any results obtained with reference to an initial portion of the breath are discarded or disregarded.
5. Apparatus according to any one of the preceding claims, comprising means for detecting a flow rate of the exhaled breath.
6. Apparatus according to claim 5, the apparatus being operable to calibrate one or more of the gas and temperature measurements in dependence on the detected flow rate.
7. Diagnostic apparatus substantially as hereinbefore described with reference to the accompanying drawings.
PCT/GB1999/004340 1998-12-18 1999-12-17 Detector WO2000036976A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU18753/00A AU1875300A (en) 1998-12-18 1999-12-17 Detector

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9828076A GB2344885A (en) 1998-12-18 1998-12-18 Diagnostic device
GB9828076.1 1998-12-18

Publications (1)

Publication Number Publication Date
WO2000036976A1 true WO2000036976A1 (en) 2000-06-29

Family

ID=10844610

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1999/004340 WO2000036976A1 (en) 1998-12-18 1999-12-17 Detector

Country Status (3)

Country Link
AU (1) AU1875300A (en)
GB (1) GB2344885A (en)
WO (1) WO2000036976A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007012930A1 (en) * 2005-07-27 2007-02-01 Delmedica Investment Limited Method and device for measurement of exhaled respiratory gas temperature
WO2012006704A1 (en) 2010-07-16 2012-01-19 Universidade De São Paulo- Usp Non-invasive method for diagnosing the severity of heart failure, use of a biomarker for diagnosing decompensated heart failure, collector device for the heart failure biomarker from exhaled breath and a diagnosis kit

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10110838C2 (en) * 2001-03-06 2003-04-03 Mlu Halle Wittenberg Methods for the diagnosis of allergies, pseudo-allergies and intolerances
DE10231541A1 (en) * 2002-07-11 2004-01-29 Gäbler, Ralph, Dr. Method for determining the response of a biological system
CN105167776A (en) * 2014-11-26 2015-12-23 深圳市一体医疗科技有限公司 Lung monitoring system

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3884219A (en) * 1973-04-02 1975-05-20 Medical Monitor Systems System for determining temperature and respiration rate
US4248245A (en) * 1978-04-15 1981-02-03 Dragerwerk Aktiengesellschaft Method and device for determining and separating the alveolar air proportion from the breathing air
US5383469A (en) * 1992-01-31 1995-01-24 Board Of Trustees Of The Leland Stanford Junior University Neonatal hemolysis detection using end-tidal breath sampler and analyzer apparatus
WO1995010980A1 (en) * 1993-10-22 1995-04-27 Medtrac Technologies Inc. Portable electronic spirometric device
GB2301440A (en) * 1992-11-04 1996-12-04 Fisher & Paykel Medical airway temperature sensor
US5622182A (en) * 1994-06-27 1997-04-22 Jaffe; Richard A. System for measuring core body temperature in vivo

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1374142A (en) * 1971-06-18 1974-11-13 Borg Warner Breath testing system with breath temperature variance compensation
US4671298A (en) * 1984-11-26 1987-06-09 Meridian Medical Corporation Isothermal rebreathing apparatus and method
US4809810A (en) * 1986-05-01 1989-03-07 Autosense Corporation Breath alcohol analyzer
AU5613894A (en) * 1993-04-01 1994-10-24 Alcohol Sensors International, Ltd. Breath sensor apparatus

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3884219A (en) * 1973-04-02 1975-05-20 Medical Monitor Systems System for determining temperature and respiration rate
US4248245A (en) * 1978-04-15 1981-02-03 Dragerwerk Aktiengesellschaft Method and device for determining and separating the alveolar air proportion from the breathing air
US5383469A (en) * 1992-01-31 1995-01-24 Board Of Trustees Of The Leland Stanford Junior University Neonatal hemolysis detection using end-tidal breath sampler and analyzer apparatus
GB2301440A (en) * 1992-11-04 1996-12-04 Fisher & Paykel Medical airway temperature sensor
WO1995010980A1 (en) * 1993-10-22 1995-04-27 Medtrac Technologies Inc. Portable electronic spirometric device
US5622182A (en) * 1994-06-27 1997-04-22 Jaffe; Richard A. System for measuring core body temperature in vivo

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007012930A1 (en) * 2005-07-27 2007-02-01 Delmedica Investment Limited Method and device for measurement of exhaled respiratory gas temperature
BG65874B1 (en) * 2005-07-27 2010-04-30 ДУНЕВ Стефан Device for measuring the temperature of exhaled air
US8323207B2 (en) 2005-07-27 2012-12-04 Delmedica Investments Limited Method and device for measurement of exhaled respiratory gas temperature
WO2012006704A1 (en) 2010-07-16 2012-01-19 Universidade De São Paulo- Usp Non-invasive method for diagnosing the severity of heart failure, use of a biomarker for diagnosing decompensated heart failure, collector device for the heart failure biomarker from exhaled breath and a diagnosis kit
US8747325B2 (en) 2010-07-16 2014-06-10 Fundacao De Amparo A Pesquisa Do Estado De Sao Paulo (Fapesp) Non-invasive method for diagnosing the severity of heart failure by extracting and analyzing acetone concentrations in captured exhaled breath

Also Published As

Publication number Publication date
AU1875300A (en) 2000-07-12
GB9828076D0 (en) 1999-02-17
GB2344885A (en) 2000-06-21

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