WO2000040179B1 - Flexible implant using partially demineralized bone - Google Patents

Flexible implant using partially demineralized bone

Info

Publication number
WO2000040179B1
WO2000040179B1 PCT/US2000/000154 US0000154W WO0040179B1 WO 2000040179 B1 WO2000040179 B1 WO 2000040179B1 US 0000154 W US0000154 W US 0000154W WO 0040179 B1 WO0040179 B1 WO 0040179B1
Authority
WO
WIPO (PCT)
Prior art keywords
bone
implant
engaging
flexible
adjacent
Prior art date
Application number
PCT/US2000/000154
Other languages
French (fr)
Other versions
WO2000040179A1 (en
Inventor
Lawrence M Boyd
John A Pafford
Original Assignee
Sdgi Holdings Inc
Lawrence M Boyd
John A Pafford
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sdgi Holdings Inc, Lawrence M Boyd, John A Pafford filed Critical Sdgi Holdings Inc
Priority to AU24054/00A priority Critical patent/AU747356B2/en
Priority to AT00902318T priority patent/ATE262866T1/en
Priority to EP00902318A priority patent/EP1139929B1/en
Priority to CA002358455A priority patent/CA2358455A1/en
Priority to JP2000591938A priority patent/JP4282239B2/en
Priority to DE60009446T priority patent/DE60009446T2/en
Publication of WO2000040179A1 publication Critical patent/WO2000040179A1/en
Publication of WO2000040179B1 publication Critical patent/WO2000040179B1/en

Links

Classifications

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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
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Abstract

Implantable devices (10) useful for creating bony fusion particularly in intervertebral spinal fusion. The device (10) is formed of bone and has an at least partially demineralized portion (16) between two rigid bone portions (12 and 14) creating an area of flexibility. In one application, the area of flexibility may be used to move the device between a reduced size insertion configuration (Fig. 2) and an expanded implanted configuration (Fig. 3). In another use, the area of flexibility may be useful to dampen shock applied to the implant (Fig. 8). A method is also disclosed for making the implants and inserting the implants into an intervertebral disc space to promote interbody fusion.

Claims

19
AMENDED CLAIMS
[received by the International Bureau on 18 July 2000 (18.07.00); original claims 1-3, 5, 6, 8-10, 13, 18, 20-23, 25, 27 and 28 amended; original claims 4, 7, 11, 12, 14-17 and 24 cancelled; remaining claims unchanged (5 pages)]
1. An implant for promoting fusion between adjacent upper and lower vertebral bodies, comprising: a first bone portion; a second bone portion; a flexible portion joining said first bone portion and said second bone portion, said flexible portion permitting movement of said first bone portion in relation to said second bone portion; and an upper bearing surface for engaging said upper vertebra and a lower bearing surface for engaging said lower vertebra separated by a first height, and said second bone portion included an upper bearing surface for engaging said upper vertebra and a lower bearing surface for engaging said lower vertebra separated by a second height, said first and second heights adapted to maintain spacing between adjacent upper and lower vertebral bodies.
2. The implant of claim 1, wherein said flexible portion is at least partially demineralized bone.
3. The implant of claim 2, wherein said flexible portion includes an area of completely demineralized bone.
5. The implant of claim 1, wherein said first height and said second height are substantially equal.
6. The implant of claim 1 , wherein each of said upper and lower bearing surfaces includes a bone engaging surface to inhibit expulsion from a disc space between two adjacent vertebra. 20
8. The implant of claim 1, wherein said first and second bone portions have corresponding tapered bearing surfaces to provide an implant having a spacing height gradually increasing from a first end to an opposite second end, wherein said implant is adapted for use in maintaining lordosis.
9. The implant of claim 1, wherein said first bone portion, said second bone portion, and said flexible portion are formed of a single bone segment.
10. The implant of claim 1, wherein the implant is substantially ring shaped
13. A spinal fusion implant adapted for insertion into the space between adjacent first and second vertebral bodies, comprising: a first bone portion having a first bearing surface for engaging a first vertebral body; a second bone portion having a second bearing surface for engaging a second vertebral body; a proximal end and an opposite distal end; a first flexible portion disposed adjacent said proximal end and a second flexible portion, spaced from said first flexible portion, disposed adjacent to said distal end; and said flexible portions permitting movement between said first bone portion and said second bone portion.
18. The implant of claim 13, wherein said first bearing surface and said second bearing surface including cooperating thread patterns permitting threaded insertion of the implant into the space between the first and second vertebral bodies. 21
19. The implant of claim 13, wherein said implant is formed of a single segment of bone.
20. A method of preparing a flexible bone implant, comprising: providing a rigid bone segment;
5 delineating an intermediate portion of the bone segment; exposing said intermediate portion to a demineralizing fluid; and limiting contact of bone adjacent the intermediate portion with the demineralizing fluid by utilizing hydrostatic pressure to limit the movement of the demineralizing fluid into the bone adjacent the intermediate portion to create a !0 flexible segment between adjacent sections of rigid bone.
21. The method of claim 20, further including forming a bone- engaging surface on the implant.
22. The method of claim 21 , wherein said bone engaging surface includes raised bone structures.
15 23. The method of claim 21, wherein said bone engaging surface is a tread pattern.
22
25. The method of claim 21 , wherein said bone engaging surface is configured to prevent movement of the implant.
26. A method of inserting an interbody fusion implant made of bone, comprising: providing an insertion tube and an implant formed of bone and having a first portion, a second portion and a central flexible portion joining the first and second portions; positioning the insertion tube adjacent a disc space between two vertebra; inserting the implant into the insertion tube; advancing the implant through the insertion tube and into the disc space; moving the first portion with respect to the second portion.
27. A method of implanting a bone implant for spinal spacing, comprising: providing a bone implant with at least a portion thereof moveable from a reduced insertion configuration to an expanded spacing configuration; delivering the implant to the disc space in the reduced insertion configuration; and positioning the implant in the expanded spacing configuration.
28. The method of claim 27, wherein said implant is at least partially resilient. 23
29. The method of claim 28, wherein said delivering is accomplished by a tube having an internal passageway configured to receive said implant in the reduced insertion configuration.
PCT/US2000/000154 1999-01-08 2000-01-05 Flexible implant using partially demineralized bone WO2000040179A1 (en)

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AU24054/00A AU747356B2 (en) 1999-01-08 2000-01-05 Flexible implant using partially demineralized bone
AT00902318T ATE262866T1 (en) 1999-01-08 2000-01-05 FLEXIBLE IMPLANT WITH PARTIALLY DEMINERALIZED BONE
EP00902318A EP1139929B1 (en) 1999-01-08 2000-01-05 Flexible implant using partially demineralized bone
CA002358455A CA2358455A1 (en) 1999-01-08 2000-01-05 Flexible implant using partially demineralized bone
JP2000591938A JP4282239B2 (en) 1999-01-08 2000-01-05 Transplant
DE60009446T DE60009446T2 (en) 1999-01-08 2000-01-05 BENDING IMPLANT WITH PARTIAL DEMINERALIZED BONE

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