WO2000041621A1 - Electrocardiograph having large low frequency dynamic range - Google Patents

Electrocardiograph having large low frequency dynamic range Download PDF

Info

Publication number
WO2000041621A1
WO2000041621A1 PCT/US2000/000585 US0000585W WO0041621A1 WO 2000041621 A1 WO2000041621 A1 WO 2000041621A1 US 0000585 W US0000585 W US 0000585W WO 0041621 A1 WO0041621 A1 WO 0041621A1
Authority
WO
WIPO (PCT)
Prior art keywords
hpf
signal
samples
ecg
frequency bandwidth
Prior art date
Application number
PCT/US2000/000585
Other languages
French (fr)
Other versions
WO2000041621A9 (en
Inventor
Dana J. Olson
David W. Van Ess
Original Assignee
Medtronic Physio-Control Manufacturing Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic Physio-Control Manufacturing Corp. filed Critical Medtronic Physio-Control Manufacturing Corp.
Publication of WO2000041621A1 publication Critical patent/WO2000041621A1/en
Publication of WO2000041621A9 publication Critical patent/WO2000041621A9/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/30Input circuits therefor
    • A61B5/307Input circuits therefor specially adapted for particular uses
    • A61B5/308Input circuits therefor specially adapted for particular uses for electrocardiography [ECG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/30Input circuits therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/38Applying electric currents by contact electrodes alternating or intermittent currents for producing shock effects
    • A61N1/39Heart defibrillators
    • A61N1/3925Monitoring; Protecting
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7232Signal processing specially adapted for physiological signals or for diagnostic purposes involving compression of the physiological signal, e.g. to extend the signal recording period
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00Surgery
    • Y10S128/901Suppression of noise in electric signal
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00Surgery
    • Y10S128/902Biological signal amplifier

Definitions

  • the present invention relates to ECG measuring systems and, more particularly, to ECG measuring systems using analog-to-digital processing.
  • ECG signal measuring system 10 A typical ECG signal measuring system 10 is shown in FIGURE 1.
  • ECG signal measuring system 10 is part of diagnostic- quality monitor/defibrillator 12.
  • ECG signal measuring system 10 is coupled to patient 14 through electrodes 15 and 16.
  • baseline wander Large amplitude, low-frequency, non-physiological signals, commonly referred to as baseline wander, can saturate an ECG measurement system, resulting in the loss of patient ECG signal information.
  • baseline wander There are several sources of baseline wander including; DC bias currents, patient movement and changing patient impedance, which are described further below.
  • ECG signal measuring systems used for emergency medical applications typically use a DC bias current to detect disconnected electrode leads. This current interacts with the patient's impedance to cause a relatively high amplitude but low frequency signal that is superimposed on the relatively low voltage ECG signal when electrodes 15 and 16 are initially applied to patient 14. For convenience, this signal is referred to herein as the bias current signal.
  • This bias current signal is illustrated in FIGURE 2 by a curve 20. As can be seen in FIGURE 2, an initial portion 21 of curve 20 has a relatively large rate of change. The bias current signal eventually begins to stabilize, as indicated by a portion 23 of curve 20. The bias current signal results in a significant rate of change of the combined input signal (i.e., the baseline wander combined with the patient ECG signal) during the initial period. This rate of change of the combined input signal is referred to herein as the slew rate. When the bias current signal eventually starts to stabilize, the slew rate of the combined input signal is reduced.
  • a similar problem is caused by movement of patient 14 or electrodes 15 or 16 that disturbs the electrical connection of electrodes 15 and 16 to patient 14. This movement can result in a significant change in the impedance presented to ECG signal measuring system 10. This change in impedance can result in a change in the bias current signal, which results in a slew rate of the combined input signal.
  • Baseline wander can also be caused by interaction of the bias current with changing patient impedance caused by the electrodes forming a better electrical connection to the patient over time.
  • FIGURE 3 is a block diagram illustrative of conventional digital ECG signal measuring system 10 (FIGURE 1).
  • ECG signal measuring system 10 includes a preamplifier 31, a high pass filter (HPF) 33, an analog-to-digital converter (ADC) 35 and a second HPF 37.
  • HPF high pass filter
  • ADC analog-to-digital converter
  • HPF 37 second HPF 37.
  • ECG signal measuring system 10 includes an anti-aliasing filter (not shown) configured to filter out frequency components of the input ECG signal above one-half of the sample rate of ADC 35.
  • the passband of HPF 33 is set at about 0.03 Hz, while the passband of HPF 37 is set at about 0.02 Hz. This gives a passband with a lower edge of 0.05 Hz.
  • This performance is consistent with industry standards for diagnostic quality ECG systems (AAMI EC-11).
  • the baseline wander signal has frequency components above 0.05Hz.
  • HPF 33 passes the baseline wander signal along with the ECG input signal to cause the saturation problem described above.
  • One conventional solution to this problem is to increase the dynamic range of the system.
  • Current industry standards require a dynamic range of at least 10 mV (i.e. ranging from ⁇ 5 mN). Diagnostic and interpretive algorithms require resolution of 5.0 ⁇ N.
  • an ECG signal measuring system having a relatively large effective dynamic range and high resolution is provided.
  • low frequency compression/enhancement techniques are combined with dither techniques to effectively increase the dynamic range while maintaining resolution. This aspect of the present invention is achieved without increasing the number of bits of the ADC.
  • the system includes a HPF, an ADC, a decimation filter (DF), and a compensation filter (CF).
  • the HPF receives an input signal (i.e., baseline wander combined with ECG input signal) and attenuates the low frequency components of the input signal. Unlike conventional systems, the HPF serves to attenuate the bias current signal so that the sampled signal remains within the dynamic range of the system. In one embodiment, the HPF attenuates frequency components that are within the frequency bandwidth of the desired ECG output signal.
  • the ADC then oversamples the output signal of the HPF.
  • the DF receives the output samples of the ADC and generates output samples at rate that is at least twice the maximum frequency of the desired ECG output signal.
  • the CF then amplifies the low frequency end of the DF output samples.
  • the gain and cutoff frequency of the CF are, ideally, set to exactly offset the HPF's attenuation of those low frequency components of the input signal below the cutoff frequency of the HPF and above the minimum frequency of the desired ECG output signal.
  • dither techniques are used, in effect, to exchange sample rate for resolution.
  • system noise noise inherent in the system due to imperfections in the components, thermal noise, etc.
  • the ECG output signal remains within the dynamic range of the system with the desired resolution, which allows the system to display an accurate ECG significantly faster than conventional systems.
  • FIGURE 1 is a diagram illustrative of a typical ECG signal measuring system.
  • FIGURE 2 is a graph illustrative of an ECG generated by a conventional ECG signal measuring system in applying electrodes to a patient.
  • FIGURE 3 is a block diagram illustrative of a conventional digital ECG signal measuring system.
  • FIGURE 4 is a block diagram illustrative of a digital ECG signal measuring system according to one embodiment of the present invention.
  • FIGURE 5 is a graph illustrative of the frequency response of the high pass filter depicted in FIGURE 4, according to one embodiment of the present invention.
  • FIGURE 6 is a graph illustrative of the frequency response of the compensation filter depicted in FIGURE 4, according to one embodiment of the present invention.
  • FIGURE 7 is a graph illustrative of the frequency response of the system depicted in FIGURE 4, according to one embodiment of the present invention.
  • FIGURE 8 is a block diagram illustrative of a digital ECG signal measuring system, according to another embodiment of the present invention.
  • FIGURE 9 is a graph illustrative of the ECG waveforms generated by the ECG signal measuring system of FIGURE 9.
  • FIGURE 10 a graph illustrative of the waveforms ECG generated by the ECG signal measuring system of FIGURE 9 with a greater high pass filter corner frequency.
  • FIGURE 4 is a block diagram illustrative of a digital ECG signal measuring system 40, according to one embodiment of the present invention.
  • ECG signal measuring system 40 includes preamplifier 31, a HPF 42, an anti-aliasing filter (AAF) 48, ADC 35, a decimation filter (DF) 44, and a compensation filter (CF) 46.
  • preamplifier 31 a HPF 42
  • AAF anti-aliasing filter
  • DF decimation filter
  • CF compensation filter
  • ECG measuring system 40 is interconnected as follows.
  • Preamplifier 31 is connected to receive the combined input signal via electrodes 15 and 16 (FIGURE 1).
  • Anti-aliasing filter (typically a LPF having a cutoff frequency less than one half of the sampling rate of the ADC) receives the output signal of preamplifier 31.
  • anti-aliasing filter 48 can be placed anywhere in the signal processing flow before ADC 35.
  • HPF 42 is connected to receive the output signal of antialiasing filter 48.
  • HPF 42 has a cutoff frequency of about 0.689Hz, which is well into the AAMI specified ECG frequency bands (e.g., diagnostic and monitor).
  • the frequency response of HPF 42 is illustrated in FIGURE 5.
  • anti-aliasing filter 48 and HPF 42 are respectively implemented in hardware as a 3rd order Butterworth analog filter and a first order analog filter.
  • ADC 35 is connected to receive the output signal of HPF 42.
  • ADC 35 is implemented using a twelve-bit ADC, such as, for example, a model AD7892 available from Analog Devices, Norwood, MA, with a 5 ksps (kilo samples-per-second) sampling rate on each of a large number of sequentially selected channels.
  • twelve-bit ADC 35 will output a digital output signal with 5 ⁇ N resolution (i.e., a uniform 5 ⁇ N step size).
  • DF 44 is connected to receive the output samples from ADC 35.
  • DF 44 is a implemented as a 61 -tap low- pass finite impulse response (FIR) filter implemented in software.
  • DF 44 computes a weighted running average of the ADC output samples, filters out the frequency components above 150 Hz, and outputs a 0.5ksps data stream.
  • the decimation is performed by shifting the 5ksps weighted running average samples into a shift register and selecting every tenth sample shifted out of the shift register to serve as the DF output data stream.
  • CF 46 is connected to receive the output data stream from DF 44.
  • CF 46 is implemented in software as a low pass digital filter with amplification or scaling of the output data stream.
  • the transfer function of CF 46 has a pole equal to the lower frequency boundary of the desired ECG output signal bandwidth (e.g., 0.05Hz) and has a zero equal to the pole of HPF 42.
  • the frequency response of CF 46 is illustrated in FIGURE 6. Consequently, the frequency response of HPF 42 cascaded with CF 46 is equivalent to a LPF having a pole at the lower frequency boundary of the desired ECG output signal bandwidth as illustrated in FIGURE 7.
  • ECG signal measuring system 40 operates as follows.
  • Preamplifier 31 receives the combined input signal from electrodes 15 and 16 (FIGURE 1).
  • the combined input signal has been filtered through AAF 48.
  • HPF 42 then filters the amplified combined input signal outputted by preamplifier 31.
  • HPF 42 filters out frequency components of the amplified combined input signal below 0.689Hz.
  • a more specific statement of the operation of HPF 42 is:
  • HHPF ( ⁇ ) X s + a ) 0 )
  • HHPF ⁇ 03 1S tne fr eo » uenc y response of HPF 42
  • variable "a" is the cutoff frequency of HPF 42 in radians.
  • "a" is set to a frequency to attenuate the aforementioned baseline wander signal to prevent saturation of ADC 35. In the above embodiment, "a” is equal to about 2(0.689) ⁇ .
  • ADC 35 samples at a rate of about 5ksps, which is significantly greater than twice the maximum frequency boundary of the desired ECG signal band. Because HPF 42 attenuates the baseline wander signal, the signal received by ADC 35 has a dynamic range no greater than 20m V, thereby preventing saturation of ADC 35. DF 44 then, as described above, low pass filters and reduces the sampling rate of the digital signal generated by ADC 35 to about 0.5ksps.
  • CF 46 then, as described above, filters the output data stream from DF 44 to compensate for the attenuation of the ECG signal frequency components below the cutoff frequency of HPF 42 and above the minimum frequency boundary of the desired ECG signal band.
  • This frequency band is referred to herein as the low-end band.
  • CF 46 provides a gain that is the inverse of the attenuation of the low-end band, which in this case is between 0.05Hz and 0.689Hz.
  • a more specific statement of the operation of CF 46 is:
  • the system noise is, in effect, a dither signal that improves resolution by modulating some of the quantization error outside the frequency band of interest.
  • dither techniques can be used to improve resolution below the least significant bit (e.g., see Vanderkooy and Lipshitz, "Resolution Below the Least Significant Bit it Digital Systems with Dither," J. Audio Eng. Soc, Vol. 32, No. 3, March, 1984, pp. 106-112).
  • the output data stream of CF 48 is then displayed in analog form using conventional circuitry.
  • oversampling provides about a half bit of increased resolution for each doubling of the sampling frequency.
  • oversampling would require an oversample ratio of about 256, resulting in a minimum sample rate of about 76.8ksps to achieve four-bit resolution improvement.
  • the oversampling ratio required to achieve the desired resolution is more strongly dependent on variable "b" rather than the upper frequency boundary of the desired ECG output signal.
  • the desired resolution can be achieved by ensuring that the oversampling ratio is at least equal to:
  • ⁇ upper represents the upper frequency boundary in radians of the desired ECG output signal. This ensures that the quantization noise power is equivalent to that of a system which does not have the low-end frequency compensation.
  • a minimum oversample ratio of about 1.06 is required, resulting in minimum sample rate of about 0.318ksps.
  • the 0.5ksps data stream provided by DF 44 exceeds the required sample rate.
  • a higher frequency "a" is required to maintain the desired dynamic range.
  • the oversampling rate is increased. For example with a HPF frequency of 5.0 Hz, the oversampling rate is calculated to be 4.33, resulting in a minimum sample rate of about 2.15 kHz.
  • FIGURE 8 is a block diagram illustrative of a digital ECG signal measuring system 90, according to another embodiment of the present invention.
  • ECG measuring system 90 is similar to ECG signal measuring system 40 (FIGURE 4) except that ECG signal measuring system 90 shows the anti-aliasing filter as a LPF 91, and includes a dither generator (DG) 92, a hardware summer or combiner 93 and a LPF 94.
  • DG 92 can be implemented with any suitable conventional signal generator.
  • CF 46 is implemented in software with a standard biquad digital filter which utilizes summers, delays and multipliers.
  • ECG signal measuring system 90 is interconnected as follows. Preamplifier 31 is connected to receive the combined signal.
  • LPF 91 functioning as an AAF, is connected to received the output signal from preamplifier 31 and provide its filtered output signal to HPF 42.
  • Combiner 93 is connected to sum the output signal from HPF 42 and DG 92.
  • ADC 35 is connected to receive the output signal from combiner 93 and provide its output samples to DF 44.
  • CF 46 is connected to receive the data stream from DF 44. CF 46 then provides its output data stream to LPF 94.
  • the output data stream of LPF 94 is then processed by conventional circuitry (not shown) to generate the ECG.
  • This embodiment of CF 46 is a standard two tap IIR filter with a Direct Form I structure, efficiently implemented in software.
  • the transfer function of this filter is equivalent to that of definition (2).
  • Another advantage of the embodiment of CF 46 is that the effective pole and zero of CF 46 can be easily changed "on-the-fly" by modifying calculation coefficients without inducing transients in the output of the filter. This allows operation of a fast restore function for baseline initialization after external transient events such as a defibrillation pulse.
  • ECG signal measuring system 90 operates essentially as described above for ECG signal measuring system 40 (FIGURE 4) except that DG 92 adds a predetermined dither signal (e.g., a triangular wave with varying between ⁇ one half of the step size of ADC 35) instead of relying on system noise.
  • a predetermined dither signal e.g., a triangular wave with varying between ⁇ one half of the step size of ADC 35
  • This embodiment may be advantageously used in applications in which the system noise is small relative to the step size of the ADC.
  • the dither signal can be used to shift the quantization noise out of the frequency range of interest.
  • LPF 94 is used to filter out the repeated or harmonic spectrums caused by the operation of the digitization process on the dithered signal.
  • DF 44 and CF 46 does not change the system response. Changing the order of processing in this manner would, however, increase the complexity and computing burden of the compensation filter by the ratio of the decimation.
  • FIGURE 9 shows the waveforms generated by a simulation of ECG signal measuring system 90.
  • the input, or raw ECG is shown as sampled at 5ksps as a waveform 80.
  • the output signal generated from HPF 42, set in this example at 0.689Hz is shown as a waveform 81.
  • Waveform 81 has a significant droop in slow moving parts of the waveform as is expected from a HPF with corner frequency in the band of interest.
  • Decimation is accomplished in DF 44 which provides 150Hz LPF at 500sps shown as a waveform 82.
  • the output signal generated from CF 46 shown as a waveform 83, is clearly nearly identical to the raw input waveform 80, maintaining the fidelity required for diagnostic interpretation of the ECG signals.
  • FIGURE 10 shows the same waveforms as FIGURE 9, but with HPF 42 and matching CF 44 corner frequencies set to 5.3Hz. This results in even greater droop in intermediate waveforms 86 and 87, the output signals generated from HPF 42 and DF 44 respectively.
  • the output signal generated from CF 46 shown as a waveform 88 has the same fidelity as the output waveform 83 of CF 46, also clearly nearly identical to the raw input waveform 80, maintaining the fidelity required for diagnostic interpretation of the ECG signals.

Abstract

An ECG signal measuring system (40) uses low frequency compression/enhancement techniques combined with dither techniques to effectively increase the dynamic range, resolution is maintained without increasing the number of bits of the ADC (35). The HPF (42) receives an input signal (i.e., the bias current combined with ECG input signal) and attenuates the low frequency components of the input signal, including a portion of the frequency band within the desired ECG frequency band. The ADC (35) oversamples the output signal of the HPF (42). The DF (44) receives the output samples of the ADC (35) and generates output samples at rate that is at least twice the maximum frequency of the desired ECG output signal. The CF (46) amplifies the low frequency end of the DF (44) output samples. The gain and cutoff frequency of the CF (46) are set to offset the HPF's (42) attenuation of those low frequency components of the input signal below the minimum frequency of the desired ECG output signal. System noise can be used as the dither.

Description

ELECTROCARDIOGRAPH HAVING LARGE LOW FREQUENCY DYNAMIC RANGE
Field of the Invention The present invention relates to ECG measuring systems and, more particularly, to ECG measuring systems using analog-to-digital processing.
Background Information When providing emergency cardiac patient care, it is essential to generate the patient's electrocardiograph (ECG) quickly and accurately for proper diagnosis and successful treatment. A typical ECG signal measuring system 10 is shown in FIGURE 1. In this example, ECG signal measuring system 10 is part of diagnostic- quality monitor/defibrillator 12. To measure the ECG signal of a patient 14, ECG signal measuring system 10 is coupled to patient 14 through electrodes 15 and 16.
Large amplitude, low-frequency, non-physiological signals, commonly referred to as baseline wander, can saturate an ECG measurement system, resulting in the loss of patient ECG signal information. There are several sources of baseline wander including; DC bias currents, patient movement and changing patient impedance, which are described further below.
ECG signal measuring systems used for emergency medical applications typically use a DC bias current to detect disconnected electrode leads. This current interacts with the patient's impedance to cause a relatively high amplitude but low frequency signal that is superimposed on the relatively low voltage ECG signal when electrodes 15 and 16 are initially applied to patient 14. For convenience, this signal is referred to herein as the bias current signal. This bias current signal is illustrated in FIGURE 2 by a curve 20. As can be seen in FIGURE 2, an initial portion 21 of curve 20 has a relatively large rate of change. The bias current signal eventually begins to stabilize, as indicated by a portion 23 of curve 20. The bias current signal results in a significant rate of change of the combined input signal (i.e., the baseline wander combined with the patient ECG signal) during the initial period. This rate of change of the combined input signal is referred to herein as the slew rate. When the bias current signal eventually starts to stabilize, the slew rate of the combined input signal is reduced.
A similar problem is caused by movement of patient 14 or electrodes 15 or 16 that disturbs the electrical connection of electrodes 15 and 16 to patient 14. This movement can result in a significant change in the impedance presented to ECG signal measuring system 10. This change in impedance can result in a change in the bias current signal, which results in a slew rate of the combined input signal.
Baseline wander can also be caused by interaction of the bias current with changing patient impedance caused by the electrodes forming a better electrical connection to the patient over time.
Conventional techniques can be used to compensate for the "offset" caused by the baseline wander in order to keep the combined input signal from saturating the system. However, the inventors of the present invention have observed conventional compensation techniques are inadequate for the high slew rate of the combined signal caused during the initial period of the bias current signal.
FIGURE 3 is a block diagram illustrative of conventional digital ECG signal measuring system 10 (FIGURE 1). ECG signal measuring system 10 includes a preamplifier 31, a high pass filter (HPF) 33, an analog-to-digital converter (ADC) 35 and a second HPF 37. As will be appreciated by those skilled in the art, ECG signal measuring system 10 includes an anti-aliasing filter (not shown) configured to filter out frequency components of the input ECG signal above one-half of the sample rate of ADC 35.
In this example, the passband of HPF 33 is set at about 0.03 Hz, while the passband of HPF 37 is set at about 0.02 Hz. This gives a passband with a lower edge of 0.05 Hz. This performance is consistent with industry standards for diagnostic quality ECG systems (AAMI EC-11). Unfortunately, the baseline wander signal has frequency components above 0.05Hz. Thus, in this example, HPF 33 passes the baseline wander signal along with the ECG input signal to cause the saturation problem described above. One conventional solution to this problem is to increase the dynamic range of the system. Current industry standards require a dynamic range of at least 10 mV (i.e. ranging from ±5 mN). Diagnostic and interpretive algorithms require resolution of 5.0 μN. This range is adequate for patients ECG signals that do not include baseline wander. Sources of baseline wander discussed above dictate that the dynamic range would have to be increased to greater than 150mN. However, to increase the dynamic range and maintain a given resolution would require an increase in the number of bits of the analog-to-digital conversion. For example, a twelve-bit ADC can be used for 20 mN dynamic range and 5 μN resolution. However, a sixteen-bit ADC may be required for 160 mN dynamic range and the same 5 μV resolution. The cost of a sixteen-bit ADC is significantly higher than a twelve-bit ADC, which undesirably increases the cost of the ECG signal measuring system. Another solution to this problem is disclosed in co-pending and commonly assigned U.S. Patent Application Serial No. 09/013,570, entitled "Digital Sliding Pole Fast Restore For An Electrocardiograph Display," Stice, et al. Although the digital sliding pole invention represents a substantial improvement over the prior art, further improvement is, of course, generally desirable. Thus, there is a need for a low cost ECG measuring system having a relatively large dynamic range and high resolution.
Summary In accordance with the present invention, an ECG signal measuring system having a relatively large effective dynamic range and high resolution is provided. In one aspect of the present invention, low frequency compression/enhancement techniques are combined with dither techniques to effectively increase the dynamic range while maintaining resolution. This aspect of the present invention is achieved without increasing the number of bits of the ADC.
In one embodiment, the system includes a HPF, an ADC, a decimation filter (DF), and a compensation filter (CF). The HPF receives an input signal (i.e., baseline wander combined with ECG input signal) and attenuates the low frequency components of the input signal. Unlike conventional systems, the HPF serves to attenuate the bias current signal so that the sampled signal remains within the dynamic range of the system. In one embodiment, the HPF attenuates frequency components that are within the frequency bandwidth of the desired ECG output signal. The ADC then oversamples the output signal of the HPF. The DF receives the output samples of the ADC and generates output samples at rate that is at least twice the maximum frequency of the desired ECG output signal. The CF then amplifies the low frequency end of the DF output samples. The gain and cutoff frequency of the CF are, ideally, set to exactly offset the HPF's attenuation of those low frequency components of the input signal below the cutoff frequency of the HPF and above the minimum frequency of the desired ECG output signal. Although it would appear that the resolution of these low frequency components has been degraded, dither techniques are used, in effect, to exchange sample rate for resolution. In one embodiment, system noise (noise inherent in the system due to imperfections in the components, thermal noise, etc.) is used as the dither. As a result of the compression/enhancement and dither techniques, the ECG output signal remains within the dynamic range of the system with the desired resolution, which allows the system to display an accurate ECG significantly faster than conventional systems.
Brief Description of the Drawings The foregoing aspects and many of the attendant advantages of this invention will become more readily appreciated by reference to the following detailed description, when taken in conjunction with the accompanying drawings listed below. FIGURE 1 is a diagram illustrative of a typical ECG signal measuring system. FIGURE 2 is a graph illustrative of an ECG generated by a conventional ECG signal measuring system in applying electrodes to a patient.
FIGURE 3 is a block diagram illustrative of a conventional digital ECG signal measuring system.
FIGURE 4 is a block diagram illustrative of a digital ECG signal measuring system according to one embodiment of the present invention.
FIGURE 5 is a graph illustrative of the frequency response of the high pass filter depicted in FIGURE 4, according to one embodiment of the present invention. FIGURE 6 is a graph illustrative of the frequency response of the compensation filter depicted in FIGURE 4, according to one embodiment of the present invention.
FIGURE 7 is a graph illustrative of the frequency response of the system depicted in FIGURE 4, according to one embodiment of the present invention. FIGURE 8 is a block diagram illustrative of a digital ECG signal measuring system, according to another embodiment of the present invention.
FIGURE 9 is a graph illustrative of the ECG waveforms generated by the ECG signal measuring system of FIGURE 9. FIGURE 10 a graph illustrative of the waveforms ECG generated by the ECG signal measuring system of FIGURE 9 with a greater high pass filter corner frequency.
Detailed Description FIGURE 4 is a block diagram illustrative of a digital ECG signal measuring system 40, according to one embodiment of the present invention. For clarity, the same reference numbers are used in the figures to indicate elements having the same or similar structure or function. In this embodiment, ECG signal measuring system 40 includes preamplifier 31, a HPF 42, an anti-aliasing filter (AAF) 48, ADC 35, a decimation filter (DF) 44, and a compensation filter (CF) 46.
ECG measuring system 40 is interconnected as follows. Preamplifier 31 is connected to receive the combined input signal via electrodes 15 and 16 (FIGURE 1). Anti-aliasing filter (typically a LPF having a cutoff frequency less than one half of the sampling rate of the ADC) receives the output signal of preamplifier 31. Alternatively, anti-aliasing filter 48 can be placed anywhere in the signal processing flow before ADC 35. HPF 42 is connected to receive the output signal of antialiasing filter 48. In this embodiment, HPF 42 has a cutoff frequency of about 0.689Hz, which is well into the AAMI specified ECG frequency bands (e.g., diagnostic and monitor). The frequency response of HPF 42 is illustrated in FIGURE 5. In this embodiment, anti-aliasing filter 48 and HPF 42 are respectively implemented in hardware as a 3rd order Butterworth analog filter and a first order analog filter.
Referring back to FIGURE 4, ADC 35 is connected to receive the output signal of HPF 42. In this embodiment, ADC 35 is implemented using a twelve-bit ADC, such as, for example, a model AD7892 available from Analog Devices, Norwood, MA, with a 5 ksps (kilo samples-per-second) sampling rate on each of a large number of sequentially selected channels. For an input signal with a 20mV dynamic range, twelve-bit ADC 35 will output a digital output signal with 5 μN resolution (i.e., a uniform 5 μN step size). DF 44 is connected to receive the output samples from ADC 35. In this embodiment, DF 44 is a implemented as a 61 -tap low- pass finite impulse response (FIR) filter implemented in software. In one embodiment, DF 44 computes a weighted running average of the ADC output samples, filters out the frequency components above 150 Hz, and outputs a 0.5ksps data stream. In this embodiment, the decimation is performed by shifting the 5ksps weighted running average samples into a shift register and selecting every tenth sample shifted out of the shift register to serve as the DF output data stream.
CF 46 is connected to receive the output data stream from DF 44. CF 46 is implemented in software as a low pass digital filter with amplification or scaling of the output data stream. In this embodiment, the transfer function of CF 46 has a pole equal to the lower frequency boundary of the desired ECG output signal bandwidth (e.g., 0.05Hz) and has a zero equal to the pole of HPF 42. The frequency response of CF 46 is illustrated in FIGURE 6. Consequently, the frequency response of HPF 42 cascaded with CF 46 is equivalent to a LPF having a pole at the lower frequency boundary of the desired ECG output signal bandwidth as illustrated in FIGURE 7.
Referring back to FIGURE 4, ECG signal measuring system 40 operates as follows. Preamplifier 31 receives the combined input signal from electrodes 15 and 16 (FIGURE 1). In this embodiment, the combined input signal has been filtered through AAF 48. HPF 42 then filters the amplified combined input signal outputted by preamplifier 31. In this embodiment, HPF 42 filters out frequency components of the amplified combined input signal below 0.689Hz. A more specific statement of the operation of HPF 42 is:
HHPF(ω) = Xs + a) 0) where HHPF^03) 1S tne freo » uency response of HPF 42 and the variable "a" is the cutoff frequency of HPF 42 in radians. As will be appreciated by those skilled in the art, "a" is set to a frequency to attenuate the aforementioned baseline wander signal to prevent saturation of ADC 35. In the above embodiment, "a" is equal to about 2(0.689)π. In many ECG signal measuring systems that conform to current industry (AAMI) standards (e.g., the ECG signal measuring system of a LIFEPAK12 monitor/defibrillator available from Medtronic Physio-Control, Redmond, WA), "a" is greater than the required lower frequency boundary of the ECG output signal. Consequently, at this point of the signal processing, preventing saturation of ADC 35 comes at the cost of undesirably attenuating the lower frequency portion of the desired ECG output signal. ADC 35 then samples the output signal from HPF 42. In this embodiment,
ADC 35 samples at a rate of about 5ksps, which is significantly greater than twice the maximum frequency boundary of the desired ECG signal band. Because HPF 42 attenuates the baseline wander signal, the signal received by ADC 35 has a dynamic range no greater than 20m V, thereby preventing saturation of ADC 35. DF 44 then, as described above, low pass filters and reduces the sampling rate of the digital signal generated by ADC 35 to about 0.5ksps.
CF 46 then, as described above, filters the output data stream from DF 44 to compensate for the attenuation of the ECG signal frequency components below the cutoff frequency of HPF 42 and above the minimum frequency boundary of the desired ECG signal band. This frequency band is referred to herein as the low-end band. In this embodiment, CF 46 provides a gain that is the inverse of the attenuation of the low-end band, which in this case is between 0.05Hz and 0.689Hz. A more specific statement of the operation of CF 46 is:
HCF( >) ^S + % + b) (2) where HcF^ω^ *s tne fi"e<luency response of CF 46, the variable "b" is the desired low frequency boundary in radians of the ECG output signal, and variable "a" is as defined above in definition (1). In the above embodiment, "b" is equal to about 2(0.05)π. Accordingly, the transfer function of HPF 42 cascaded with CF 46 is:
Figure imgf000009_0001
where sYS^ω^ 1S tne fre(luency response of HPF 42 cascaded with CF 46, and the variable "b" is as defined above in definition (2). It might appear that this compensation by CF 46 degrades the resolution of the system because the scaling of the low-end band also scales the step size. For example, if CF 46 amplifies a certain portion of the low-end band by ten, then the resolution of that portion would appear to be 25 μN. However, the inventors of the present invention have observed that the essentially random system or thermal noise injected into the combined input signal before ADC 35 has an average level greater than the step size or resolution of ADC 35. Thus, the system noise is, in effect, a dither signal that improves resolution by modulating some of the quantization error outside the frequency band of interest. In this way, dither techniques can be used to improve resolution below the least significant bit (e.g., see Vanderkooy and Lipshitz, "Resolution Below the Least Significant Bit it Digital Systems with Dither," J. Audio Eng. Soc, Vol. 32, No. 3, March, 1984, pp. 106-112). The output data stream of CF 48 is then displayed in analog form using conventional circuitry.
In light of this disclosure, those skilled in the art of sample data systems typified by ECG signal measuring systems will appreciate that dither techniques can improve the resolution beyond the improvement provided by oversampling alone. For example, oversampling provides about a half bit of increased resolution for each doubling of the sampling frequency. Thus, using oversampling alone would require an oversample ratio of about 256, resulting in a minimum sample rate of about 76.8ksps to achieve four-bit resolution improvement. However, it can be shown that because the de-emphasis and enhancement is performed only on the low-end band, the oversampling ratio required to achieve the desired resolution is more strongly dependent on variable "b" rather than the upper frequency boundary of the desired ECG output signal. In particular, the desired resolution can be achieved by ensuring that the oversampling ratio is at least equal to:
Figure imgf000010_0001
where ωupper represents the upper frequency boundary in radians of the desired ECG output signal. This ensures that the quantization noise power is equivalent to that of a system which does not have the low-end frequency compensation. Thus, to achieve a resolution within 5 μN using the present invention, a minimum oversample ratio of about 1.06 is required, resulting in minimum sample rate of about 0.318ksps. The 0.5ksps data stream provided by DF 44 exceeds the required sample rate. There may be a system situation where a higher frequency "a" is required to maintain the desired dynamic range. In this case the oversampling rate is increased. For example with a HPF frequency of 5.0 Hz, the oversampling rate is calculated to be 4.33, resulting in a minimum sample rate of about 2.15 kHz.
FIGURE 8 is a block diagram illustrative of a digital ECG signal measuring system 90, according to another embodiment of the present invention. ECG measuring system 90 is similar to ECG signal measuring system 40 (FIGURE 4) except that ECG signal measuring system 90 shows the anti-aliasing filter as a LPF 91, and includes a dither generator (DG) 92, a hardware summer or combiner 93 and a LPF 94. DG 92 can be implemented with any suitable conventional signal generator. Further, in this embodiment, CF 46 is implemented in software with a standard biquad digital filter which utilizes summers, delays and multipliers. ECG signal measuring system 90 is interconnected as follows. Preamplifier 31 is connected to receive the combined signal. LPF 91, functioning as an AAF, is connected to received the output signal from preamplifier 31 and provide its filtered output signal to HPF 42. Combiner 93 is connected to sum the output signal from HPF 42 and DG 92. ADC 35 is connected to receive the output signal from combiner 93 and provide its output samples to DF 44. CF 46 is connected to receive the data stream from DF 44. CF 46 then provides its output data stream to LPF 94. The output data stream of LPF 94 is then processed by conventional circuitry (not shown) to generate the ECG.
This embodiment of CF 46 is a standard two tap IIR filter with a Direct Form I structure, efficiently implemented in software. The transfer function of this filter is equivalent to that of definition (2). Another advantage of the embodiment of CF 46 is that the effective pole and zero of CF 46 can be easily changed "on-the-fly" by modifying calculation coefficients without inducing transients in the output of the filter. This allows operation of a fast restore function for baseline initialization after external transient events such as a defibrillation pulse.
ECG signal measuring system 90 operates essentially as described above for ECG signal measuring system 40 (FIGURE 4) except that DG 92 adds a predetermined dither signal (e.g., a triangular wave with varying between ±one half of the step size of ADC 35) instead of relying on system noise. This embodiment may be advantageously used in applications in which the system noise is small relative to the step size of the ADC. However, when DG 92 is configured to generate a known periodic dither signal, the dither signal can be used to shift the quantization noise out of the frequency range of interest.
LPF 94 is used to filter out the repeated or harmonic spectrums caused by the operation of the digitization process on the dithered signal. In addition, those skilled in the art will appreciate that interchanging the order of processing by DF 44 and CF 46 does not change the system response. Changing the order of processing in this manner would, however, increase the complexity and computing burden of the compensation filter by the ratio of the decimation.
FIGURE 9 shows the waveforms generated by a simulation of ECG signal measuring system 90. The input, or raw ECG, is shown as sampled at 5ksps as a waveform 80. The output signal generated from HPF 42, set in this example at 0.689Hz is shown as a waveform 81. Waveform 81 has a significant droop in slow moving parts of the waveform as is expected from a HPF with corner frequency in the band of interest. Decimation is accomplished in DF 44 which provides 150Hz LPF at 500sps shown as a waveform 82. The output signal generated from CF 46, shown as a waveform 83, is clearly nearly identical to the raw input waveform 80, maintaining the fidelity required for diagnostic interpretation of the ECG signals. FIGURE 10 shows the same waveforms as FIGURE 9, but with HPF 42 and matching CF 44 corner frequencies set to 5.3Hz. This results in even greater droop in intermediate waveforms 86 and 87, the output signals generated from HPF 42 and DF 44 respectively. The output signal generated from CF 46, shown as a waveform 88 has the same fidelity as the output waveform 83 of CF 46, also clearly nearly identical to the raw input waveform 80, maintaining the fidelity required for diagnostic interpretation of the ECG signals.
The embodiments of the ECG signal measuring system described above are illustrative of the principles of the present invention and are not intended to limit the invention to the particular embodiments described. For example, in light of the present disclosure, those skilled in the art can devise, without undue experimentation, embodiments using different implementations of the CF or different dither signals. In addition, those skilled in the art, in light of the present disclosure, can adjust the sampling rate and decimation ratio to accommodate different output ECG signal frequency bandwidths and low-end bands. Accordingly, while the preferred embodiment of the invention has been illustrated and described, it will be appreciated that various changes can be made therein without departing from the spirit and scope of the invention.

Claims

The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows:
1. A method of filtering a sensed ECG signal from a patient in generating an output ECG signal having a predetermined frequency bandwidth, the method comprising: filtering the input ECG signal with an anti-aliasing filter; filtering an output signal from the anti-aliasing filter with a high pass filter (HPF), the cutoff frequency of the HPF being within the predetermined frequency bandwidth, wherein a low-band portion of the predetermined frequency bandwidth is attenuated; sampling an output signal from the HPF to generate a stream of samples with a predetermined sample rate greater than twice the upper frequency of the predetermined frequency bandwidth; and filtering the stream of samples with a compensation filter (CF), wherein the CF provides a gain for the low-band portion that is substantially equal to the inverse of the attenuation of the low-band portion.
2. The method of Claim 1 wherein the CF is implemented in software.
3. The method of Claim 1 further comprising decimating the stream of samples.
4. The method of Claim 1 further comprising combining a known dither signal with the output signal from the HPF.
5. The method of Claim 4 wherein the dither signal has a dynamic range at least as great as the resolution of each sample of the stream of samples.
6. The method of Claim 1 wherein the resolution of each sample of the stream of samples is within about 5 microvolts and the predetermined frequency bandwidth ranges from about 0.05Hz to about 150Hz.
7. The method of Claim 6 wherein the sample rate is about 5000 samples per second.
8. The method of Claim 6 wherein the HPF is implemented in hardware.
9. An ECG filter system for use in generating an output ECG signal having a predetermined frequency bandwidth in response to a sensed ECG signal from a patient, the system comprising: an anti-aliasing filter coupled to receive the sensed ECG signal; a high pass filter (HPF) coupled to the anti-aliasing filter, the HPF having a cutoff frequency within the predetermined frequency bandwidth, wherein the HPF is configured to attenuate a low-band portion of the predetermined frequency bandwidth; an analog-to-digital converter (ADC) coupled to the HPF, the ADC being configured to generate a stream of samples with a predetermined sample rate greater than twice the upper frequency of the predetermined frequency bandwidth; and a compensation filter (CF) coupled to the ADC, wherein the CF is configured to provide a gain for the low-band portion that is substantially equal to the inverse of the attenuation of the low-band portion.
10. The system of Claim 9, wherein the CF comprises a digital filter implemented in software.
11. The system of Claim 9 further comprising a decimator coupled to the CF.
12. The system of Claim 9 further comprising a dither generator circuit configured to combine a known dither signal with the output signal from the HPF.
13. The system of Claim 12 wherein the dither signal has a dynamic range at least as great as the resolution of each sample of the stream of samples.
14. The system of Claim 9 wherein the resolution of each sample of the stream of samples is within about 5 microvolts and the predetermined frequency bandwidth ranges from about 0.05Hz to about 150Hz.
15. The system of Claim 14 wherein the sample rate is about 5000 samples per second.
16. The system of Claim 14 wherein the HPF is implemented in hardware.
17. An ECG filter system for use in generating an output ECG signal having a predetermined frequency bandwidth in response to a sensed ECG signal from a patient, the system comprising: an anti-aliasing filter coupled to receive the sensed ECG signal; a high pass filter (HPF) coupled to the anti-aliasing filter, the HPF having a cutoff frequency within the predetermined frequency bandwidth, wherein the HPF is configured to attenuate a low-band portion of the predetermined frequency bandwidth; an analog-to-digital converter (ADC) coupled to the HPF, the ADC being configured to generate a stream of samples with a predetermined sample rate greater than twice the upper frequency of the predetermined frequency bandwidth; and compensation means, coupled to the ADC, for digitally filtering the stream of samples, wherein the compensation means is configured to provide a gain for the low- band portion that is substantially equal to the inverse of the attenuation of the low- band portion.
18. The system of Claim 17, wherein the CF is a digital filter implemented in software.
19. The system of Claim 17 further comprising decimating the stream of samples.
20. The system of Claim 17 further comprising a dither generator circuit configured to combine a known dither signal with the output signal from the HPF.
21. The system of Claim 20 wherein the dither signal has a dynamic range at least as great as the resolution of each sample of the stream of samples.
22. The system of Claim 17 wherein the resolution of each sample of the stream of samples is within about 5 microvolts and the predetermined frequency bandwidth ranges from about 0.05Hz to about 150Hz.
23. The system of Claim 22 wherein the HPF is implemented in hardware.
24. A defibrillator having an ECG filter system for use in generating an output ECG signal in response to an ECG signal from a patient, the output ECG signal having a predetermined frequency bandwidth, the defibrillator comprising: a pair of electrodes, wherein the pair of electrodes is configured to provide a sensed ECG signal in response to signals generated by the patient's heart; an anti-aliasing filter coupled to receive the sensed ECG signal; a high pass filter (HPF) coupled to the anti-aliasing filter, the HPF having a cutoff frequency within the predetermined frequency bandwidth, wherein the HPF is configured to attenuate a low-band portion of the predetermined frequency bandwidth; an analog-to-digital converter (ADC) coupled to the HPF, the ADC being configured to generate a stream of samples with a predetermined sample rate greater than twice the upper frequency of the predetermined frequency bandwidth; a compensation filter (CF) coupled to the ADC, wherein the CF is configured to provide a gain for the low-band portion that is substantially equal to the inverse of the attenuation of the low-band portion; and a display system coupled to the compensation filter, the display system being configured to display an ECG waveform in response to an output signal generated by the CF.
25. The defibrillator of Claim 24, wherein the CF comprises a digital filter implemented in software.
26. The defibrillator of Claim 24 further comprising a decimator coupled to the CF.
27. The defibrillator of Claim 24 further comprising a dither generator circuit configured to combine a known dither signal with the output signal from the HPF.
28. The defibrillator of Claim 27 wherein the dither signal has a dynamic range at least as great as the resolution of each sample of the stream of samples.
29. The defibrillator of Claim 29 wherein the HPF is implemented in hardware.
PCT/US2000/000585 1999-01-15 2000-01-10 Electrocardiograph having large low frequency dynamic range WO2000041621A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/232,044 1999-01-15
US09/232,044 US6249696B1 (en) 1999-01-15 1999-01-15 Method and apparatus for increasing the low frequency dynamic range of a digital ECG measuring system

Publications (2)

Publication Number Publication Date
WO2000041621A1 true WO2000041621A1 (en) 2000-07-20
WO2000041621A9 WO2000041621A9 (en) 2002-05-02

Family

ID=22871650

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/000585 WO2000041621A1 (en) 1999-01-15 2000-01-10 Electrocardiograph having large low frequency dynamic range

Country Status (2)

Country Link
US (2) US6249696B1 (en)
WO (1) WO2000041621A1 (en)

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2247943A1 (en) * 2004-08-27 2006-03-01 Gem-Med S.L. Cardioelectric signal processing method, involves detecting cardioelectric signal by detector, and filtering all smaller frequencies to certain minimum threshold value to obtain filtered signal
EP3003442A4 (en) * 2013-05-29 2016-12-14 Hospira Inc Infusion system and method of use which prevents over-saturation of an analog-to-digital converter
US9995611B2 (en) 2012-03-30 2018-06-12 Icu Medical, Inc. Air detection system and method for detecting air in a pump of an infusion system
US10022498B2 (en) 2011-12-16 2018-07-17 Icu Medical, Inc. System for monitoring and delivering medication to a patient and method of using the same to minimize the risks associated with automated therapy
US10046112B2 (en) 2013-05-24 2018-08-14 Icu Medical, Inc. Multi-sensor infusion system for detecting air or an occlusion in the infusion system
US10166328B2 (en) 2013-05-29 2019-01-01 Icu Medical, Inc. Infusion system which utilizes one or more sensors and additional information to make an air determination regarding the infusion system
US10342917B2 (en) 2014-02-28 2019-07-09 Icu Medical, Inc. Infusion system and method which utilizes dual wavelength optical air-in-line detection
US10430761B2 (en) 2011-08-19 2019-10-01 Icu Medical, Inc. Systems and methods for a graphical interface including a graphical representation of medical data
US10463788B2 (en) 2012-07-31 2019-11-05 Icu Medical, Inc. Patient care system for critical medications
US10635784B2 (en) 2007-12-18 2020-04-28 Icu Medical, Inc. User interface improvements for medical devices
US10656894B2 (en) 2017-12-27 2020-05-19 Icu Medical, Inc. Synchronized display of screen content on networked devices
RU2723222C1 (en) * 2019-11-18 2020-06-09 Евгений Владимирович Круглов Electric cardiosignal processing unit with analogue-digital filtration
US10850024B2 (en) 2015-03-02 2020-12-01 Icu Medical, Inc. Infusion system, device, and method having advanced infusion features
US11135360B1 (en) 2020-12-07 2021-10-05 Icu Medical, Inc. Concurrent infusion with common line auto flush
US11246985B2 (en) 2016-05-13 2022-02-15 Icu Medical, Inc. Infusion pump system and method with common line auto flush
US11278671B2 (en) 2019-12-04 2022-03-22 Icu Medical, Inc. Infusion pump with safety sequence keypad
US11324888B2 (en) 2016-06-10 2022-05-10 Icu Medical, Inc. Acoustic flow sensor for continuous medication flow measurements and feedback control of infusion
US11344668B2 (en) 2014-12-19 2022-05-31 Icu Medical, Inc. Infusion system with concurrent TPN/insulin infusion
US11344673B2 (en) 2014-05-29 2022-05-31 Icu Medical, Inc. Infusion system and pump with configurable closed loop delivery rate catch-up
US11883361B2 (en) 2020-07-21 2024-01-30 Icu Medical, Inc. Fluid transfer devices and methods of use

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7613508B2 (en) * 2001-09-25 2009-11-03 Pacesetter, Inc. Implantable cardiac stimulation device, system and method which provides an electrogram signal facilitating measurement of slow-changing electrogram features
US6658283B1 (en) 2001-09-25 2003-12-02 Pacesetter, Inc. Implantable cardiac stimulation device, system and method which provides an electrogram signal having the appearance of a surface electrocardiogram
US6865420B1 (en) 2002-01-14 2005-03-08 Pacesetter, Inc. Cardiac stimulation device for optimizing cardiac output with myocardial ischemia protection
US7120484B2 (en) * 2002-01-14 2006-10-10 Medtronic, Inc. Methods and apparatus for filtering EGM signals detected by an implantable medical device
DE102004021520B4 (en) * 2004-05-03 2008-07-03 Sattler Ag Coated, water vapor permeable and fungus resistant fabrics
KR100929084B1 (en) * 2004-12-03 2009-11-30 삼성전자주식회사 Dithering device and method in communication system
US20060229522A1 (en) * 2005-04-08 2006-10-12 Exelys, Llc Portable cardiac monitor including RF communication
US7474914B2 (en) * 2005-04-08 2009-01-06 Exelys, Llc Portable cardiac monitor including a range limiter
US7361188B2 (en) * 2005-04-08 2008-04-22 Exelys, Llc Portable cardiac monitor
US20060229525A1 (en) * 2005-04-08 2006-10-12 Exelys, Llc Portable cardiac monitor including pulsed power operation
US20070078353A1 (en) * 2005-10-04 2007-04-05 Welch Allyn, Inc. Method and apparatus for removing baseline wander from an ECG signal
US8180442B2 (en) * 2007-12-14 2012-05-15 Greatbatch Ltd. Deriving patient activity information from sensed body electrical information
US8915866B2 (en) 2008-01-18 2014-12-23 Warsaw Orthopedic, Inc. Implantable sensor and associated methods
US8390374B2 (en) 2011-01-25 2013-03-05 Analog Devices, Inc. Apparatus and method for amplification with high front-end gain in the presence of large DC offsets
US8319553B1 (en) 2011-08-02 2012-11-27 Analog Devices, Inc. Apparatus and methods for biasing amplifiers
US8432222B2 (en) 2011-09-15 2013-04-30 Analog Devices, Inc. Apparatus and methods for electronic amplification
US8552788B2 (en) 2011-09-15 2013-10-08 Analog Devices, Inc. Apparatus and methods for adaptive common-mode level shifting
US10736529B2 (en) 2013-09-25 2020-08-11 Bardy Diagnostics, Inc. Subcutaneous insertable electrocardiography monitor
US10433751B2 (en) 2013-09-25 2019-10-08 Bardy Diagnostics, Inc. System and method for facilitating a cardiac rhythm disorder diagnosis based on subcutaneous cardiac monitoring data
US9433380B1 (en) 2013-09-25 2016-09-06 Bardy Diagnostics, Inc. Extended wear electrocardiography patch
US20190167139A1 (en) 2017-12-05 2019-06-06 Gust H. Bardy Subcutaneous P-Wave Centric Insertable Cardiac Monitor For Long Term Electrocardiographic Monitoring
US10667711B1 (en) 2013-09-25 2020-06-02 Bardy Diagnostics, Inc. Contact-activated extended wear electrocardiography and physiological sensor monitor recorder
US9364155B2 (en) 2013-09-25 2016-06-14 Bardy Diagnostics, Inc. Self-contained personal air flow sensing monitor
US9408551B2 (en) 2013-11-14 2016-08-09 Bardy Diagnostics, Inc. System and method for facilitating diagnosis of cardiac rhythm disorders with the aid of a digital computer
US9504423B1 (en) 2015-10-05 2016-11-29 Bardy Diagnostics, Inc. Method for addressing medical conditions through a wearable health monitor with the aid of a digital computer
US10251576B2 (en) 2013-09-25 2019-04-09 Bardy Diagnostics, Inc. System and method for ECG data classification for use in facilitating diagnosis of cardiac rhythm disorders with the aid of a digital computer
US10736531B2 (en) 2013-09-25 2020-08-11 Bardy Diagnostics, Inc. Subcutaneous insertable cardiac monitor optimized for long term, low amplitude electrocardiographic data collection
US10806360B2 (en) 2013-09-25 2020-10-20 Bardy Diagnostics, Inc. Extended wear ambulatory electrocardiography and physiological sensor monitor
US9615763B2 (en) 2013-09-25 2017-04-11 Bardy Diagnostics, Inc. Ambulatory electrocardiography monitor recorder optimized for capturing low amplitude cardiac action potential propagation
US9717432B2 (en) 2013-09-25 2017-08-01 Bardy Diagnostics, Inc. Extended wear electrocardiography patch using interlaced wire electrodes
US9717433B2 (en) 2013-09-25 2017-08-01 Bardy Diagnostics, Inc. Ambulatory electrocardiography monitoring patch optimized for capturing low amplitude cardiac action potential propagation
US9345414B1 (en) 2013-09-25 2016-05-24 Bardy Diagnostics, Inc. Method for providing dynamic gain over electrocardiographic data with the aid of a digital computer
US10433748B2 (en) 2013-09-25 2019-10-08 Bardy Diagnostics, Inc. Extended wear electrocardiography and physiological sensor monitor
US10165946B2 (en) 2013-09-25 2019-01-01 Bardy Diagnostics, Inc. Computer-implemented system and method for providing a personal mobile device-triggered medical intervention
US9619660B1 (en) 2013-09-25 2017-04-11 Bardy Diagnostics, Inc. Computer-implemented system for secure physiological data collection and processing
US11213237B2 (en) 2013-09-25 2022-01-04 Bardy Diagnostics, Inc. System and method for secure cloud-based physiological data processing and delivery
US10463269B2 (en) 2013-09-25 2019-11-05 Bardy Diagnostics, Inc. System and method for machine-learning-based atrial fibrillation detection
US9655538B2 (en) 2013-09-25 2017-05-23 Bardy Diagnostics, Inc. Self-authenticating electrocardiography monitoring circuit
US10624551B2 (en) 2013-09-25 2020-04-21 Bardy Diagnostics, Inc. Insertable cardiac monitor for use in performing long term electrocardiographic monitoring
US9655537B2 (en) 2013-09-25 2017-05-23 Bardy Diagnostics, Inc. Wearable electrocardiography and physiology monitoring ensemble
US10799137B2 (en) 2013-09-25 2020-10-13 Bardy Diagnostics, Inc. System and method for facilitating a cardiac rhythm disorder diagnosis with the aid of a digital computer
US10888239B2 (en) 2013-09-25 2021-01-12 Bardy Diagnostics, Inc. Remote interfacing electrocardiography patch
US9730593B2 (en) 2013-09-25 2017-08-15 Bardy Diagnostics, Inc. Extended wear ambulatory electrocardiography and physiological sensor monitor
US9775536B2 (en) 2013-09-25 2017-10-03 Bardy Diagnostics, Inc. Method for constructing a stress-pliant physiological electrode assembly
US9700227B2 (en) 2013-09-25 2017-07-11 Bardy Diagnostics, Inc. Ambulatory electrocardiography monitoring patch optimized for capturing low amplitude cardiac action potential propagation
US11723575B2 (en) 2013-09-25 2023-08-15 Bardy Diagnostics, Inc. Electrocardiography patch
US9433367B2 (en) 2013-09-25 2016-09-06 Bardy Diagnostics, Inc. Remote interfacing of extended wear electrocardiography and physiological sensor monitor
WO2015048194A1 (en) 2013-09-25 2015-04-02 Bardy Diagnostics, Inc. Self-contained personal air flow sensing monitor
US10820801B2 (en) 2013-09-25 2020-11-03 Bardy Diagnostics, Inc. Electrocardiography monitor configured for self-optimizing ECG data compression
KR102162491B1 (en) * 2014-01-06 2020-10-06 삼성전자주식회사 Method and apparatus of detecting interference signal for low power envelope detector
CN103989470B (en) * 2014-05-30 2016-01-27 中国科学院微电子研究所 Ecg signal acquiring equipment, dynamic cardiograph, system and method for transmitting signals
US11109790B2 (en) * 2015-11-18 2021-09-07 Samsung Electronics Co., Ltd. Patch including an external floating high-pass filter and an electrocardiograph (ECG) patch including the same
US10973429B2 (en) 2018-01-23 2021-04-13 Chelak Iecg, Inc. Precise localization of cardiac arrhythmia using internal electrocardiograph (ECG) signals sensed and stored by implantable device
US11096579B2 (en) 2019-07-03 2021-08-24 Bardy Diagnostics, Inc. System and method for remote ECG data streaming in real-time
US11696681B2 (en) 2019-07-03 2023-07-11 Bardy Diagnostics Inc. Configurable hardware platform for physiological monitoring of a living body
US11116451B2 (en) 2019-07-03 2021-09-14 Bardy Diagnostics, Inc. Subcutaneous P-wave centric insertable cardiac monitor with energy harvesting capabilities
US11707233B1 (en) 2022-12-16 2023-07-25 Wisear Simultaneous sub-Nyquist acquisition of a plurality of bioelectric signals

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1357098A (en) 1919-10-18 1920-10-26 Frank L Kryder Cord tire
US4800364A (en) * 1985-07-15 1989-01-24 Mortara David W Analog-to-digital converter utilizing vernier techniques
US5357969A (en) * 1993-03-18 1994-10-25 Hewlett-Packard Company Method and apparatus for accurately displaying an ECG signal
US5772603A (en) * 1993-07-16 1998-06-30 Siemens-Elema Ab Device for filtering ECG signals

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3569852A (en) 1969-01-23 1971-03-09 American Optical Corp Frequency selective variable gain amplifier
US3868567A (en) * 1973-11-26 1975-02-25 Univ Washington Measurement of ST depression of electrocardiograms
US4147162A (en) 1977-06-10 1979-04-03 Hewlett-Packard Company Defibrillator monitor baseline control
US4153049A (en) 1977-11-16 1979-05-08 Hewlett-Packard Company Apparatus for maintaining signals within a given amplitude range
US4194511A (en) 1978-08-18 1980-03-25 Electronics For Medicine, Inc. Detecting capacitively coupled ECG baseline shift
US4556063A (en) 1980-10-07 1985-12-03 Medtronic, Inc. Telemetry system for a medical device
US4494551A (en) 1982-11-12 1985-01-22 Medicomp, Inc. Alterable frequency response electrocardiographic amplifier
US4479922A (en) 1983-04-04 1984-10-30 At&T Technologies, Inc. Solvent treatment in the separation of palladium and/or gold from other platinum group and base metals
US5042026A (en) 1987-03-03 1991-08-20 Nec Corporation Circuit for cancelling whole or part of a waveform using nonrecursive and recursive filters
DE4106858A1 (en) 1991-03-04 1992-09-10 Siemens Ag ARRANGEMENT FOR FILTERING BASELINE FLUCTUATIONS FROM PHYSIOLOGICAL MEASURING SIGNALS
DE69210395T2 (en) 1991-04-05 1997-01-09 Medtronic Inc DETECTION SYSTEM WITH SUBCUTANEOUS MULTIPLE ELECTRODES
US5215098A (en) * 1991-08-12 1993-06-01 Telectronics Pacing Systems, Inc. Data compression of cardiac electrical signals using scanning correlation and temporal data compression
US5318036A (en) 1992-03-17 1994-06-07 Hewlett-Packard Company Method and apparatus for removing baseline wander from an ECG signal
US5297557A (en) 1992-10-14 1994-03-29 Del Mar Avionics Stress test system with bidirectional filter
US5406955A (en) 1993-03-12 1995-04-18 Hewlett-Packard Corporation ECG recorder and playback unit
SE9302433D0 (en) 1993-07-16 1993-07-16 Siemens-Elema Ab DEVICE FOR ELIMINATION OF RINGS WITH FILTERED ECG SIGNALS
US5762068A (en) 1995-11-27 1998-06-09 Quinton Instrument Company ECG filter and slew rate limiter for filtering an ECG signal
FR2758221B1 (en) * 1997-01-07 1999-03-26 Ela Medical Sa DEVICE FOR FILTERING HEART ACTIVITY SIGNALS
US6128526A (en) 1999-03-29 2000-10-03 Medtronic, Inc. Method for ischemia detection and apparatus for using same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1357098A (en) 1919-10-18 1920-10-26 Frank L Kryder Cord tire
US4800364A (en) * 1985-07-15 1989-01-24 Mortara David W Analog-to-digital converter utilizing vernier techniques
US5357969A (en) * 1993-03-18 1994-10-25 Hewlett-Packard Company Method and apparatus for accurately displaying an ECG signal
US5772603A (en) * 1993-07-16 1998-06-30 Siemens-Elema Ab Device for filtering ECG signals

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ANTTI RUHA ET AL: "MICROPOWER ANALOG STRUCTURES FOR A CMOS HEART RATE INDICATOR", PROCEEDINGS OF THE MIDWEST SYMPOSIUM ON CIRCUITS AND SYSTEMS,US,NEW YORK, IEEE, vol. SYMP. 32, 1989, pages 689 - 692, XP000139746 *
LEUNG S W ; ZHANG Y T: "Digitization of electrocardiogram (ECG) signals using delta-sigma modulation", PROCEEDINGS OF THE 20TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, vol. 20, no. 4, 1998, Piscataway, NJ, USA, pages 1964 - 1966, XP002138113 *

Cited By (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2247943A1 (en) * 2004-08-27 2006-03-01 Gem-Med S.L. Cardioelectric signal processing method, involves detecting cardioelectric signal by detector, and filtering all smaller frequencies to certain minimum threshold value to obtain filtered signal
US10635784B2 (en) 2007-12-18 2020-04-28 Icu Medical, Inc. User interface improvements for medical devices
US11599854B2 (en) 2011-08-19 2023-03-07 Icu Medical, Inc. Systems and methods for a graphical interface including a graphical representation of medical data
US11004035B2 (en) 2011-08-19 2021-05-11 Icu Medical, Inc. Systems and methods for a graphical interface including a graphical representation of medical data
US10430761B2 (en) 2011-08-19 2019-10-01 Icu Medical, Inc. Systems and methods for a graphical interface including a graphical representation of medical data
US10022498B2 (en) 2011-12-16 2018-07-17 Icu Medical, Inc. System for monitoring and delivering medication to a patient and method of using the same to minimize the risks associated with automated therapy
US11376361B2 (en) 2011-12-16 2022-07-05 Icu Medical, Inc. System for monitoring and delivering medication to a patient and method of using the same to minimize the risks associated with automated therapy
US11933650B2 (en) 2012-03-30 2024-03-19 Icu Medical, Inc. Air detection system and method for detecting air in a pump of an infusion system
US9995611B2 (en) 2012-03-30 2018-06-12 Icu Medical, Inc. Air detection system and method for detecting air in a pump of an infusion system
US10578474B2 (en) 2012-03-30 2020-03-03 Icu Medical, Inc. Air detection system and method for detecting air in a pump of an infusion system
US11623042B2 (en) 2012-07-31 2023-04-11 Icu Medical, Inc. Patient care system for critical medications
US10463788B2 (en) 2012-07-31 2019-11-05 Icu Medical, Inc. Patient care system for critical medications
US10874793B2 (en) 2013-05-24 2020-12-29 Icu Medical, Inc. Multi-sensor infusion system for detecting air or an occlusion in the infusion system
US10046112B2 (en) 2013-05-24 2018-08-14 Icu Medical, Inc. Multi-sensor infusion system for detecting air or an occlusion in the infusion system
EP3003442A4 (en) * 2013-05-29 2016-12-14 Hospira Inc Infusion system and method of use which prevents over-saturation of an analog-to-digital converter
US9707341B2 (en) 2013-05-29 2017-07-18 Icu Medical, Inc. Infusion system and method of use which prevents over-saturation of an analog-to-digital converter
US10596316B2 (en) 2013-05-29 2020-03-24 Icu Medical, Inc. Infusion system and method of use which prevents over-saturation of an analog-to-digital converter
US11596737B2 (en) 2013-05-29 2023-03-07 Icu Medical, Inc. Infusion system and method of use which prevents over-saturation of an analog-to-digital converter
US11433177B2 (en) 2013-05-29 2022-09-06 Icu Medical, Inc. Infusion system which utilizes one or more sensors and additional information to make an air determination regarding the infusion system
US10166328B2 (en) 2013-05-29 2019-01-01 Icu Medical, Inc. Infusion system which utilizes one or more sensors and additional information to make an air determination regarding the infusion system
US10342917B2 (en) 2014-02-28 2019-07-09 Icu Medical, Inc. Infusion system and method which utilizes dual wavelength optical air-in-line detection
US11344673B2 (en) 2014-05-29 2022-05-31 Icu Medical, Inc. Infusion system and pump with configurable closed loop delivery rate catch-up
US11344668B2 (en) 2014-12-19 2022-05-31 Icu Medical, Inc. Infusion system with concurrent TPN/insulin infusion
US10850024B2 (en) 2015-03-02 2020-12-01 Icu Medical, Inc. Infusion system, device, and method having advanced infusion features
US11246985B2 (en) 2016-05-13 2022-02-15 Icu Medical, Inc. Infusion pump system and method with common line auto flush
US11324888B2 (en) 2016-06-10 2022-05-10 Icu Medical, Inc. Acoustic flow sensor for continuous medication flow measurements and feedback control of infusion
US10656894B2 (en) 2017-12-27 2020-05-19 Icu Medical, Inc. Synchronized display of screen content on networked devices
US11029911B2 (en) 2017-12-27 2021-06-08 Icu Medical, Inc. Synchronized display of screen content on networked devices
US11868161B2 (en) 2017-12-27 2024-01-09 Icu Medical, Inc. Synchronized display of screen content on networked devices
RU2723222C1 (en) * 2019-11-18 2020-06-09 Евгений Владимирович Круглов Electric cardiosignal processing unit with analogue-digital filtration
US11278671B2 (en) 2019-12-04 2022-03-22 Icu Medical, Inc. Infusion pump with safety sequence keypad
US11883361B2 (en) 2020-07-21 2024-01-30 Icu Medical, Inc. Fluid transfer devices and methods of use
US11135360B1 (en) 2020-12-07 2021-10-05 Icu Medical, Inc. Concurrent infusion with common line auto flush

Also Published As

Publication number Publication date
WO2000041621A9 (en) 2002-05-02
US6249696B1 (en) 2001-06-19
US6317625B1 (en) 2001-11-13

Similar Documents

Publication Publication Date Title
US6249696B1 (en) Method and apparatus for increasing the low frequency dynamic range of a digital ECG measuring system
Kher Signal processing techniques for removing noise from ECG signals
Cyrill et al. Adaptive comb filters for quasiperiodic physiologic signals
US6280391B1 (en) Method and apparatus for removing baseline wander from an egg signal
EP0634135B1 (en) Device for filtering ECG signals
JP4293639B2 (en) Low power digital filter apparatus and method
US5297557A (en) Stress test system with bidirectional filter
US10194815B2 (en) Variable bandwidth ECG high pass filter
US7783339B2 (en) Method and system for real-time digital filtering for electrophysiological and hemodynamic amplifers
JPH10229975A (en) Device for filtering heartbeat signal
Verulkar et al. Filtering techniques for reduction of power line interference in electrocardiogram signals
Chavan et al. Comparative study of Chebyshev I and Chebyshev II filter used for noise reduction in ECG signal
Kwatra et al. A new technique for monitoring heart signals-part I: instrumentation design
Karnewar et al. The combined effect of median and FIR filter in pre-processing of ECG signal using matlab
JP6560206B2 (en) ECG high-pass filter, ECG monitor and defibrillator
Bai et al. Adjustable 60Hz noise reduction and ECG signal amplification of a remote electrocardiogram system
EP3893723B1 (en) Filtering unit for electrocardiography applications
Dotsinsky et al. Fast electrocardiogram amplifier recovery after defibrillation shock
Neycheva et al. Intuitive Approach to active digital filter design. Part II: Principle of higher-order low-pass filters
PARULEKAR et al. COMPARISON OF FILTER OUTPUTS FOR ECG SIGNALS
Vityazeva et al. Accuracy Loss in Multi-Rate Processing of Biomedical Signals
KR20180058050A (en) Apparatus for generating ecg signal
Levkov et al. Subtraction Method for Powerline Interference Removing from ECG
Janousek et al. A New Filtering Method for Smoothing Intracardiac Records Preserving the Steepness of A, V, H Waves
US20040205424A1 (en) Differential filter with high common mode rejection ratio

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): CN IL IN JP RU

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
COP Corrected version of pamphlet

Free format text: PAGES 1/5-5/5, DRAWINGS, REPLACED BY NEW PAGES 1/5-5/5; DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE

122 Ep: pct application non-entry in european phase
DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)