WO2000042219A1 - Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites - Google Patents
Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites Download PDFInfo
- Publication number
- WO2000042219A1 WO2000042219A1 PCT/US2000/000388 US0000388W WO0042219A1 WO 2000042219 A1 WO2000042219 A1 WO 2000042219A1 US 0000388 W US0000388 W US 0000388W WO 0042219 A1 WO0042219 A1 WO 0042219A1
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- WIPO (PCT)
- Prior art keywords
- target site
- zinc finger
- protein
- target
- triplet
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- C—CHEMISTRY; METALLURGY
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1089—Design, preparation, screening or analysis of libraries using computer algorithms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6875—Nucleoproteins
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/30—Detection of binding sites or motifs
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/50—Mutagenesis
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
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- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
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- Theoretical Computer Science (AREA)
- Urology & Nephrology (AREA)
- Evolutionary Biology (AREA)
- Medicinal Chemistry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Wood Science & Technology (AREA)
- Medical Informatics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE60005100T DE60005100T2 (en) | 1999-01-12 | 2000-01-06 | SELECTION OF TARGET REGIONS FOR ZINC FINGER PROTEINS AND METHODS FOR THE DESIGN OF ZINC FINGER PROTEINS THAT BIND TO PRESELECTED REGIONS |
EP00905563A EP1075540B1 (en) | 1999-01-12 | 2000-01-06 | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
AU27220/00A AU744171B2 (en) | 1999-01-12 | 2000-01-06 | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
CA2322700A CA2322700C (en) | 1999-01-12 | 2000-01-06 | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to binds to preselected sites |
AT00905563T ATE249522T1 (en) | 1999-01-12 | 2000-01-06 | SELECTION OF TARGET REGIONS FOR ZINC FINGER PROTEINS AND METHODS FOR DESIGNING ZINC FINGER PROTEINS WHICH BIND TO PRESELECTED REGIONS |
JP2000593776A JP4350907B2 (en) | 1999-01-12 | 2000-01-06 | Selection of sites targeted by zinc finger proteins and methods for designing zinc finger proteins that bind to preselected sites |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/229,007 | 1999-01-12 | ||
US09/229,007 US6453242B1 (en) | 1999-01-12 | 1999-01-12 | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000042219A1 true WO2000042219A1 (en) | 2000-07-20 |
WO2000042219A9 WO2000042219A9 (en) | 2002-05-02 |
Family
ID=22859459
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/000388 WO2000042219A1 (en) | 1999-01-12 | 2000-01-06 | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
Country Status (9)
Country | Link |
---|---|
US (4) | US6453242B1 (en) |
EP (2) | EP1352975B1 (en) |
JP (3) | JP4350907B2 (en) |
AT (2) | ATE249522T1 (en) |
AU (1) | AU744171B2 (en) |
CA (1) | CA2322700C (en) |
DE (2) | DE60031007T2 (en) |
GB (1) | GB2348425B (en) |
WO (1) | WO2000042219A1 (en) |
Cited By (96)
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WO2001053478A2 (en) * | 2000-01-24 | 2001-07-26 | Gendaq Limited | Methods for regulating transcription in plants by introduction of engireed zinc finger polypeptides |
WO2001083793A2 (en) * | 2000-04-28 | 2001-11-08 | Sangamo Biosciences, Inc. | Targeted modification of chromatin structure |
WO2002008286A2 (en) * | 2000-07-21 | 2002-01-31 | Syngenta Participations Ag | Zinc finger domain recognition code and uses thereof |
WO2002026960A2 (en) * | 2000-09-29 | 2002-04-04 | Sangamo Biosciences, Inc. | Modulation of gene expression using localization domains |
WO2002042459A2 (en) * | 2000-11-20 | 2002-05-30 | Sangamo Biosciences, Inc. | Position dependent recognition of gnn nucleotide triplets by zinc fingers |
WO2002044353A2 (en) * | 2000-11-30 | 2002-06-06 | Sangamo Biosciences, Inc. | Human heparanase gene regulatory sequences |
WO2002046412A2 (en) * | 2000-12-07 | 2002-06-13 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
WO2002057308A2 (en) * | 2001-01-22 | 2002-07-25 | Sangamo Biosciences, Inc. | Zinc finger polypeptides and their use |
US6511808B2 (en) | 2000-04-28 | 2003-01-28 | Sangamo Biosciences, Inc. | Methods for designing exogenous regulatory molecules |
WO2003020887A2 (en) * | 2001-08-28 | 2003-03-13 | Sangamo Biosciences, Inc. | Gene identification |
WO2003027247A2 (en) | 2001-09-24 | 2003-04-03 | Sangamo Biosciences, Inc. | Modulation of stem cells using zinc finger proteins |
US6607882B1 (en) | 1999-01-12 | 2003-08-19 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
US6610489B2 (en) | 2000-04-28 | 2003-08-26 | Sangamo Biosciences, Inc. | Pharmacogenomics and identification of drug targets by reconstruction of signal transduction pathways based on sequences of accessible regions |
EP1353941A2 (en) * | 2001-01-22 | 2003-10-22 | Sangamo Biosciences Inc. | Modified zinc finger binding proteins |
US6689558B2 (en) | 2000-02-08 | 2004-02-10 | Sangamo Biosciences, Inc. | Cells for drug discovery |
EP1421177A2 (en) * | 2001-08-20 | 2004-05-26 | The Scripps Research Institute | Zinc finger binding domains for cnn |
US6919204B2 (en) | 2000-09-29 | 2005-07-19 | Sangamo Biosciences, Inc. | Modulation of gene expression using localization domains |
US7013219B2 (en) | 1999-01-12 | 2006-03-14 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
US7030215B2 (en) * | 1999-03-24 | 2006-04-18 | Sangamo Biosciences, Inc. | Position dependent recognition of GNN nucleotide triplets by zinc fingers |
US7070934B2 (en) | 1999-01-12 | 2006-07-04 | Sangamo Biosciences, Inc. | Ligand-controlled regulation of endogenous gene expression |
USRE39229E1 (en) | 1994-08-20 | 2006-08-08 | Gendaq Limited | Binding proteins for recognition of DNA |
WO2006105511A1 (en) | 2005-03-31 | 2006-10-05 | The General Hospital Corporation | Monitoring and modulating hgf/hgfr activity |
US7202025B1 (en) | 1999-06-30 | 2007-04-10 | Gene Expression Technologies Limited | Control of gene expression |
US7217509B2 (en) | 2000-04-28 | 2007-05-15 | Sangamo Biosciences, Inc. | Databases of regulatory sequences; methods of making and using same |
US7262055B2 (en) | 1998-08-25 | 2007-08-28 | Gendaq Limited | Regulated gene expression in plants |
US7262054B2 (en) | 2002-01-22 | 2007-08-28 | Sangamo Biosciences, Inc. | Zinc finger proteins for DNA binding and gene regulation in plants |
US7285416B2 (en) | 2000-01-24 | 2007-10-23 | Gendaq Limited | Regulated gene expression in plants |
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AU2722000A (en) | 2000-08-01 |
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JP5162405B2 (en) | 2013-03-13 |
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US7788044B2 (en) | 2010-08-31 |
US6785613B2 (en) | 2004-08-31 |
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US20030092000A1 (en) | 2003-05-15 |
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