WO2000042417A8 - An apparatus and method for the rapid spectral resolution of confocal images - Google Patents

An apparatus and method for the rapid spectral resolution of confocal images

Info

Publication number
WO2000042417A8
WO2000042417A8 PCT/US1999/030863 US9930863W WO0042417A8 WO 2000042417 A8 WO2000042417 A8 WO 2000042417A8 US 9930863 W US9930863 W US 9930863W WO 0042417 A8 WO0042417 A8 WO 0042417A8
Authority
WO
WIPO (PCT)
Prior art keywords
scanning microscope
confocal scanning
sample
detector
microscope apparatus
Prior art date
Application number
PCT/US1999/030863
Other languages
French (fr)
Other versions
WO2000042417A1 (en
Inventor
Michael J Stimson
John D Simon
Original Assignee
Univ Duke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Duke filed Critical Univ Duke
Priority to EP99969290A priority Critical patent/EP1117987A4/en
Priority to AU28455/00A priority patent/AU2845500A/en
Priority to CA002368156A priority patent/CA2368156A1/en
Publication of WO2000042417A1 publication Critical patent/WO2000042417A1/en
Publication of WO2000042417A8 publication Critical patent/WO2000042417A8/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/2823—Imaging spectrometer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/2803—Investigating the spectrum using photoelectric array detector
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0036—Scanning details, e.g. scanning stages
    • G02B21/0048—Scanning details, e.g. scanning stages scanning mirrors, e.g. rotating or galvanomirrors, MEMS mirrors
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0056—Optical details of the image generation based on optical coherence, e.g. phase-contrast arrangements, interference arrangements
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence

Abstract

A confocal scanning microscope apparatus and method is used to rapidly acquire spectrally resolved images. The confocal scanning microscope apparatus includes optics used to simultaneously acquire at least two points along a scan pattern on a sample plane of a sample, wherein the points include regions of the sample represented by at least two pixels. A detection arm (418) is placed in the path of the light reflected, scattered, or emitted from the sample plane (414) comprising a spectrometer (428) having a slit for receiving such light and a detector array (432) placed behind the spectrometer. The image corresponding to the at least two points is recorded on the first axis of said detector and spectral resolution thereof is simultaneously recorded on the second axis of the detector. The confocal scanning microscope apparatus and method offers significant improvements to the current techniques for genetic sequencing, as well as significant improvements to traditional confocal scanning microscope applications.
PCT/US1999/030863 1999-01-14 1999-12-23 An apparatus and method for the rapid spectral resolution of confocal images WO2000042417A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP99969290A EP1117987A4 (en) 1999-01-14 1999-12-23 An apparatus and method for the rapid spectral resolution of confocal images
AU28455/00A AU2845500A (en) 1999-01-14 1999-12-23 An apparatus and method for the rapid spectral resolution of confocal images
CA002368156A CA2368156A1 (en) 1999-01-14 1999-12-23 An apparatus and method for the rapid spectral resolution of confocal images

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/229,874 US6134002A (en) 1999-01-14 1999-01-14 Apparatus and method for the rapid spectral resolution of confocal images
US09/229,874 1999-01-14

Publications (2)

Publication Number Publication Date
WO2000042417A1 WO2000042417A1 (en) 2000-07-20
WO2000042417A8 true WO2000042417A8 (en) 2001-02-22

Family

ID=22863019

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/030863 WO2000042417A1 (en) 1999-01-14 1999-12-23 An apparatus and method for the rapid spectral resolution of confocal images

Country Status (5)

Country Link
US (1) US6134002A (en)
EP (1) EP1117987A4 (en)
AU (1) AU2845500A (en)
CA (1) CA2368156A1 (en)
WO (1) WO2000042417A1 (en)

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Also Published As

Publication number Publication date
EP1117987A4 (en) 2004-08-11
AU2845500A (en) 2000-08-01
US6134002A (en) 2000-10-17
EP1117987A2 (en) 2001-07-25
WO2000042417A1 (en) 2000-07-20
CA2368156A1 (en) 2000-07-20

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