WO2000042897A3 - Method and apparatus for measurement of microtome performance - Google Patents

Method and apparatus for measurement of microtome performance Download PDF

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Publication number
WO2000042897A3
WO2000042897A3 PCT/US2000/001511 US0001511W WO0042897A3 WO 2000042897 A3 WO2000042897 A3 WO 2000042897A3 US 0001511 W US0001511 W US 0001511W WO 0042897 A3 WO0042897 A3 WO 0042897A3
Authority
WO
WIPO (PCT)
Prior art keywords
microtome
block
specular
image
performance
Prior art date
Application number
PCT/US2000/001511
Other languages
French (fr)
Other versions
WO2000042897A2 (en
Inventor
Russell L Kerschmann
Michael E Bolles
Andrew D Hendrickson
Original Assignee
Russell L Kerschmann
Michael E Bolles
Andrew D Hendrickson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Russell L Kerschmann, Michael E Bolles, Andrew D Hendrickson filed Critical Russell L Kerschmann
Priority to AU27337/00A priority Critical patent/AU2733700A/en
Priority to JP2000594365A priority patent/JP2002535630A/en
Priority to EP00905692A priority patent/EP1148806A2/en
Publication of WO2000042897A2 publication Critical patent/WO2000042897A2/en
Publication of WO2000042897A3 publication Critical patent/WO2000042897A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10056—Microscopic image
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30168—Image quality inspection

Abstract

A method and apparatus for monitoring (30) and evaluating (36a, 42a) the performance and condition of histology laboratory microtomes and microtome accessories including knives (32d), motor drives, and illumination devices (32b). Irregularities in an image of the surface of a block (40a) mounted on the microtome are detected and characterized (40b), the block having been subjected to mechanical sectioning by the microtome to produce a cut block face. The image of light reflected from the surface of the block, either specular or non-specular, is recorded (raw specular image) and subjected to graphical analysis to extract, quantify, and interpret patterned features, including those indicating anomalies in the function of the microtome, its accessories, or the tissue block itself (42b, 42c, and 42d)..
PCT/US2000/001511 1999-01-21 2000-01-21 Method and apparatus for measurement of microtome performance WO2000042897A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU27337/00A AU2733700A (en) 1999-01-21 2000-01-21 Method and apparatus for measurement of microtome performance
JP2000594365A JP2002535630A (en) 1999-01-21 2000-01-21 Method and apparatus for measuring microtome performance
EP00905692A EP1148806A2 (en) 1999-01-21 2000-01-21 Method and apparatus for measurement of microtome performance

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/235,345 US6330348B1 (en) 1999-01-21 1999-01-21 Method and apparatus for measurement of microtome performance
US09/235,345 1999-01-21

Publications (2)

Publication Number Publication Date
WO2000042897A2 WO2000042897A2 (en) 2000-07-27
WO2000042897A3 true WO2000042897A3 (en) 2000-11-30

Family

ID=22885111

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/001511 WO2000042897A2 (en) 1999-01-21 2000-01-21 Method and apparatus for measurement of microtome performance

Country Status (6)

Country Link
US (1) US6330348B1 (en)
EP (1) EP1148806A2 (en)
JP (1) JP2002535630A (en)
CN (1) CN1337030A (en)
AU (1) AU2733700A (en)
WO (1) WO2000042897A2 (en)

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EP3471020B1 (en) 2005-01-27 2021-03-03 Leica Biosystems Imaging Inc. Systems and methods for viewing three dimensional virtual slides
US8164622B2 (en) * 2005-07-01 2012-04-24 Aperio Technologies, Inc. System and method for single optical axis multi-detector microscope slide scanner
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JP5484048B2 (en) 2006-06-30 2014-05-07 アペリオ・テクノロジーズ・インコーポレイテッド Large image storage and retrieval method via DICOM
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DE102006041208B4 (en) * 2006-09-02 2014-08-07 Leica Biosystems Nussloch Gmbh Measuring device for a vibrating microtome and vibrating microtome with a measuring device
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DE202007007160U1 (en) * 2007-05-19 2007-08-02 Leica Microsystems Nussloch Gmbh Device for producing thin sections
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JP5102152B2 (en) * 2008-08-29 2012-12-19 サクラファインテックジャパン株式会社 Automatic slicer
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US9784648B2 (en) 2010-09-07 2017-10-10 President And Fellows Of Harvard College Methods, apparatuses and systems for collection of tissue sections
JP5766004B2 (en) * 2011-04-26 2015-08-19 倉敷紡績株式会社 Thin section sample preparation device and thin section sample preparation method
DE102012101377B4 (en) 2012-02-21 2017-02-09 Leica Biosystems Nussloch Gmbh Method of preparing samples for microscopy and device for checking the cover quality of samples
US9799113B2 (en) 2015-05-21 2017-10-24 Invicro Llc Multi-spectral three dimensional imaging system and method
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US10473557B2 (en) 2015-06-30 2019-11-12 Clarapath, Inc. Method, system, and device for automating transfer of tape to microtome sections
EP3859425B1 (en) * 2015-09-17 2024-04-17 S.D. Sight Diagnostics Ltd. Methods and apparatus for detecting an entity in a bodily sample
CA3018536A1 (en) 2016-03-30 2017-10-05 S.D. Sight Diagnostics Ltd Distinguishing between blood sample components
US11307196B2 (en) 2016-05-11 2022-04-19 S.D. Sight Diagnostics Ltd. Sample carrier for optical measurements
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Also Published As

Publication number Publication date
AU2733700A (en) 2000-08-07
US6330348B1 (en) 2001-12-11
CN1337030A (en) 2002-02-20
EP1148806A2 (en) 2001-10-31
JP2002535630A (en) 2002-10-22
WO2000042897A2 (en) 2000-07-27

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