WO2000044357A3 - Agent for preventing in-stent restenoses and post-operative inflammations - Google Patents

Agent for preventing in-stent restenoses and post-operative inflammations Download PDF

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Publication number
WO2000044357A3
WO2000044357A3 PCT/DE2000/000228 DE0000228W WO0044357A3 WO 2000044357 A3 WO2000044357 A3 WO 2000044357A3 DE 0000228 W DE0000228 W DE 0000228W WO 0044357 A3 WO0044357 A3 WO 0044357A3
Authority
WO
WIPO (PCT)
Prior art keywords
agent
post
preventing
fullerenes
inflammations
Prior art date
Application number
PCT/DE2000/000228
Other languages
German (de)
French (fr)
Other versions
WO2000044357A2 (en
Inventor
Heinrich Leonhardt
Original Assignee
Max Delbrueck Centrum
Heinrich Leonhardt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Delbrueck Centrum, Heinrich Leonhardt filed Critical Max Delbrueck Centrum
Publication of WO2000044357A2 publication Critical patent/WO2000044357A2/en
Publication of WO2000044357A3 publication Critical patent/WO2000044357A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

The invention relates to an agent for preventing post-operative inflammations, especially following the implantation of objects, particularly stents and pacemakers. The agent is for use in the field of medicine and in the pharmaceutical industry and is characterised in that it contains fullerenes as antioxidative free-radical scavengers. These are preferably fullerenes with 60-100 C-atoms, derivatised fullerenes and high molecular fullerene nanofibres. The agent can also contain a resorbable layer consisting of biodegradable polymers or antiproliferative substances.
PCT/DE2000/000228 1999-01-29 2000-01-27 Agent for preventing in-stent restenoses and post-operative inflammations WO2000044357A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19903385A DE19903385A1 (en) 1999-01-29 1999-01-29 Agent for the prevention of in-stent restenosis and post-operative inflammation
DE19903385.4 1999-01-29

Publications (2)

Publication Number Publication Date
WO2000044357A2 WO2000044357A2 (en) 2000-08-03
WO2000044357A3 true WO2000044357A3 (en) 2001-04-26

Family

ID=7895670

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2000/000228 WO2000044357A2 (en) 1999-01-29 2000-01-27 Agent for preventing in-stent restenoses and post-operative inflammations

Country Status (2)

Country Link
DE (1) DE19903385A1 (en)
WO (1) WO2000044357A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8956637B2 (en) 2003-04-17 2015-02-17 Nanosys, Inc. Medical device applications of nanostructured surfaces
US9364565B2 (en) 2000-03-15 2016-06-14 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods of using same
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2400319C (en) 2000-03-15 2008-09-16 Orbus Medical Technologies Inc. Coating that promotes endothelial cell adherence
DE10136642A1 (en) * 2001-07-20 2003-02-06 Biotronik Mess & Therapieg Disposable medical device
CN100455275C (en) * 2002-02-06 2009-01-28 祥丰医疗有限公司 Medical device with coating that promotes endothelial cell adherence and differentiation
EP1501563A1 (en) * 2002-05-03 2005-02-02 Duke University Medical Center Carbon nanotubules for storage of nitric oxide
US20050038498A1 (en) * 2003-04-17 2005-02-17 Nanosys, Inc. Medical device applications of nanostructured surfaces
US7163956B2 (en) 2003-10-10 2007-01-16 C Sixty Inc. Substituted fullerene compositions and their use as antioxidants
WO2005079339A2 (en) * 2004-02-12 2005-09-01 The University Of Akron Improved stent for use in arteries

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995021637A1 (en) * 1994-02-10 1995-08-17 British Technology Group Limited Membrane with anti-viral properties
EP0694633A1 (en) * 1994-07-29 1996-01-31 Hoechst Aktiengesellschaft Fibres, films or hollow objects made of compositions containing polyester and fullerene, process for the preparation of the compositions and their use
EP0770577A1 (en) * 1995-10-26 1997-05-02 Long Y. Chiang Fullerene derivatives as free-radical scavengers
WO1999032184A1 (en) * 1997-12-19 1999-07-01 Cordis Corporation Catheter system having fullerenes and method

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995021637A1 (en) * 1994-02-10 1995-08-17 British Technology Group Limited Membrane with anti-viral properties
EP0694633A1 (en) * 1994-07-29 1996-01-31 Hoechst Aktiengesellschaft Fibres, films or hollow objects made of compositions containing polyester and fullerene, process for the preparation of the compositions and their use
EP0770577A1 (en) * 1995-10-26 1997-05-02 Long Y. Chiang Fullerene derivatives as free-radical scavengers
US5994410A (en) * 1995-10-26 1999-11-30 National Science Council Therapeutic use of water-soluble fullerene derivatives
WO1999032184A1 (en) * 1997-12-19 1999-07-01 Cordis Corporation Catheter system having fullerenes and method

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHUEH S -C ET AL: "Decrease of free radical level in organ perfusate by a novel water-soluble carbon-sixty, hexa(sulfobutyl)fullerenes.", TRANSPLANTATION PROCEEDINGS, vol. 31, no. 5, August 1999 (1999-08-01), pages 1976 - 1977, XP000964751, ISSN: 0041-1345 *
HUANG, HUEI-CHEN ET AL: "Antiproliferative effect of polyhydroxylated C60 on vascular smooth muscle cells", PROC. - ELECTROCHEM. SOC. (1996), 96-10(RECENT ADVANCES IN THE CHEMISTRY AND PHYSICS OF FULLERENES AND RELATED MATERIALS, VOL. 3), 403-410, XP000964676 *
JENSEN A.W. ET AL: "Biological applications of fullerenes.", BIOORGANIC AND MEDICINAL CHEMISTRY, (1996) 4/6 (767-779)., XP000965597 *
LU, LIANG-HUEI ET AL: "The possible mechanisms of the antiproliferative effect of fullerenol, polyhydroxylated C60, on vascular smooth muscle cells", BR. J. PHARMACOL. (1998), 123(6), 1097-1102, XP000964661 *
SATOH M ET AL: "Inhibitory effect of a fullerene derivative, monomalonic acid C60, on nitric oxide-dependent relaxation of aortic smooth muscle.", GENERAL PHARMACOLOGY, (1997 SEP) 29 (3) 345-51., XP000964666 *
SATOH, MITSUTOSHI ET AL: "Inhibitory effects of a fullerene derivative, dimalonic acid C60, on nitric oxide-induced relaxation of rabbit aorta", EUR. J. PHARMACOL. (1997), 327(2/3), 175-181, XP000964595 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9364565B2 (en) 2000-03-15 2016-06-14 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods of using same
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
US8956637B2 (en) 2003-04-17 2015-02-17 Nanosys, Inc. Medical device applications of nanostructured surfaces

Also Published As

Publication number Publication date
DE19903385A1 (en) 2000-08-03
WO2000044357A2 (en) 2000-08-03

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