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Numéro de publicationWO2000046405 A3
Type de publicationDemande
Numéro de demandePCT/US2000/002882
Date de publication10 mai 2001
Date de dépôt2 févr. 2000
Date de priorité2 févr. 1999
Autre référence de publicationEP1147229A2, US8606553, US8635031, US20020012939, US20080270096, US20150112652, US20170053059, WO2000046405A2, WO2000046405A9
Numéro de publicationPCT/2000/2882, PCT/US/0/002882, PCT/US/0/02882, PCT/US/2000/002882, PCT/US/2000/02882, PCT/US0/002882, PCT/US0/02882, PCT/US0002882, PCT/US002882, PCT/US2000/002882, PCT/US2000/02882, PCT/US2000002882, PCT/US200002882, WO 0046405 A3, WO 0046405A3, WO 2000/046405 A3, WO 2000046405 A3, WO 2000046405A3, WO-A3-0046405, WO-A3-2000046405, WO0046405 A3, WO0046405A3, WO2000/046405A3, WO2000046405 A3, WO2000046405A3
InventeursBernhard Palsson
DéposantBernhard Palsson
Exporter la citationBiBTeX, EndNote, RefMan
Liens externes:  Patentscope, Espacenet
Procedes d'identification de cibles pour medicaments a partir de donnees de sequence genomique
WO 2000046405 A3
Résumé
La présente invention concerne une approche informatique permettant d'identifier des cibles potentielles pour des médicaments antibactériens à partir d'une séquence génomique et du commentaire correspondant. A partir d'un génome totalement séquencé, des localisations des phases de lecture ouvertes sont effectuées afin de déterminer le génotype métabolique de l'organisme. Le génotype métabolique, et plus spécifiquement sa matrice stoechiométrique, sont analysés par analyse de l'équilibre de flux afin d'évaluer les effets des délétions génétiques sur le bon fonctionnement de l'organisme et son abilité à produire les biomolécules essentielles nécessaires à la croissance.
Citations hors brevets
Référence
1 *ARIGONI ET AL: "A GENOME-BASED APPROACH FOR THE IDENTIFICATION OF ESSENTIAL BACTERIAL GENES", NATURE BIOTECHNOLOGY,US,NATURE PUBLISHING, vol. 16, no. 9, September 1998 (1998-09-01), pages 851 - 856, XP002119419, ISSN: 1087-0156
2 *BALTZ ET AL: "DNA sequence sampling of the Streptococcus pneumoniae genome to identify novel targets for antibiotic development", MICROBIAL DRUG RESISTANCE,US,LIEBERT, vol. 4, no. 1, 21 March 1998 (1998-03-21), pages 1 - 9, XP002112153, ISSN: 1076-6294
3 *BONARIUS H P J ET AL: "Flux analysis of underdetermined metabolic networks: the quest for the missing constraints", TRENDS IN BIOTECHNOLOGY,GB,ELSEVIER PUBLICATIONS, CAMBRIDGE, vol. 15, no. 8, 1 August 1997 (1997-08-01), pages 308 - 314, XP004083358, ISSN: 0167-7799
4 *EDWARDS JEREMY S ET AL: "How will bioinformatics influence metabolic engineering?", BIOTECHNOLOGY AND BIOENGINEERING, vol. 58, no. 2-3, 20 April 1998 (1998-04-20), pages 162 - 169, XP002153942, ISSN: 0006-3592
5 *GALPERIN M Y ET AL: "Using metabolic pathway databases for functional annotation", TRENDS IN GENETICS,NL,ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, vol. 14, no. 8, 1 December 1998 (1998-12-01), pages 332 - 333, XP004131498, ISSN: 0168-9525
6 *KARP P D: "Metabolic databases", TIBS TRENDS IN BIOCHEMICAL SCIENCES,EN,ELSEVIER PUBLICATION, CAMBRIDGE, vol. 23, no. 3, 1 March 1998 (1998-03-01), pages 114 - 116, XP004111317, ISSN: 0968-0004
7 *KARP PETER D ET AL: "EcoCyc: Encyclopedia of Escherichia coli genes and metabolism.", NUCLEIC ACIDS RESEARCH, vol. 25, no. 1, 1997, pages 43 - 50, XP002153948, ISSN: 0305-1048
8 *PALSSON: "What lies beyond bioinformatics?", NATURE BIOTECHNOLOGY, vol. 15, January 1997 (1997-01-01), pages 3 - 4, XP002153943
9 *PRAMANIK J ET AL: "Stoichiometric model of Escherichia coli metabolism: Incorporation of growth-rate dependent biomass composition and mechanistic energy requirements.", BIOTECHNOLOGY AND BIOENGINEERING, vol. 56, no. 4, 1997, pages 398 - 421, XP002153946, ISSN: 0006-3592
10 *SAUER UWE ET AL: "Metabolic capacity of Bacillus subtilis for the production of purine nucleosides, riboflavin, and folic acid.", BIOTECHNOLOGY AND BIOENGINEERING, vol. 59, no. 2, 20 July 1998 (1998-07-20), pages 227 - 238, XP002153947, ISSN: 0006-3592
11 *SCHILLING CHRISTOPHE H ET AL: "The underlying pathway structure of biochemical reaction networks.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 95, no. 8, 14 April 1998 (1998-04-14), April 14, 1998, pages 4193 - 4198, XP002153944, ISSN: 0027-8424
12 *SCHILLING CHRISTOPHE H ET AL: "Toward metabolic phenomics: Analysis of genomic data using flux balances.", BIOTECHNOLOGY PROGRESS, vol. 15, no. 3, May 1999 (1999-05-01), pages 288 - 295, XP000961124, ISSN: 8756-7938
13 *TOMITA MASARU ET AL: "E-CELL: Software environment for whole-cell simulation.", BIOINFORMATICS (OXFORD), vol. 15, no. 1, January 1999 (1999-01-01), pages 72 - 84, XP000961128, ISSN: 1367-4803
14 *XIE L ET AL: "Integrated approaches to the design of media and feeding strategies for fed-batch cultures of animal cells", TRENDS IN BIOTECHNOLOGY,GB,ELSEVIER PUBLICATIONS, CAMBRIDGE, vol. 15, no. 3, 1 March 1997 (1997-03-01), pages 109 - 113, XP004054783, ISSN: 0167-7799
Classifications
Classification internationaleG06F19/18, G06F19/12, C12N15/10
Classification coopérativeG06F19/18, C40B30/02, G06F19/12, C12N15/1034
Classification européenneC12N15/10C, G06F19/12
Événements juridiques
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