WO2000050004A3 - Surgical anesthesia delivery system - Google Patents

Surgical anesthesia delivery system Download PDF

Info

Publication number
WO2000050004A3
WO2000050004A3 PCT/US2000/004594 US0004594W WO0050004A3 WO 2000050004 A3 WO2000050004 A3 WO 2000050004A3 US 0004594 W US0004594 W US 0004594W WO 0050004 A3 WO0050004 A3 WO 0050004A3
Authority
WO
WIPO (PCT)
Prior art keywords
delivery
composition
lidocaine
anesthetics
situ
Prior art date
Application number
PCT/US2000/004594
Other languages
French (fr)
Other versions
WO2000050004A2 (en
Inventor
Frederick J Foley
Lorraine E Reeve
James S Sharrow
Thomas G Adelman
Original Assignee
Ioteck Inc
Frederick J Foley
Lorraine E Reeve
James S Sharrow
Thomas G Adelman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ioteck Inc, Frederick J Foley, Lorraine E Reeve, James S Sharrow, Thomas G Adelman filed Critical Ioteck Inc
Priority to AU33735/00A priority Critical patent/AU3373500A/en
Publication of WO2000050004A2 publication Critical patent/WO2000050004A2/en
Publication of WO2000050004A3 publication Critical patent/WO2000050004A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants

Abstract

A system, including composition and delivery device, for the delivery of anesthetics such as lidocaine in the course of soft tissue surgery, e.g., soft tissue ablation, dissection and debulking. The system finds particular use in the delivery of anesthetics such as lidocaine to urothelial surfaces and periurethelial tissues in the course of minimally invasive surgical prostatic procedures such as transurethral needle ablation (TUNA). A composition can be delivered in the form of a low viscosity gel or solution at ambient temperatures, and is adapted to form a highly viscous solution or gel in situ by increasing its viscosity in response to the elevated body temperatures or suitable means. Once gelled in situ, the composition can serve as a drug reservoir sufficient to hold the anesthetic in place, and optionally, can also serve as a conductive medium for iontophoretic delivery.
PCT/US2000/004594 1999-02-23 2000-02-23 Surgical anesthesia delivery system WO2000050004A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU33735/00A AU3373500A (en) 1999-02-23 2000-02-23 Surgical anesthesia delivery system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12123399P 1999-02-23 1999-02-23
US60/121,233 1999-02-23

Publications (2)

Publication Number Publication Date
WO2000050004A2 WO2000050004A2 (en) 2000-08-31
WO2000050004A3 true WO2000050004A3 (en) 2001-09-07

Family

ID=22395392

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/004594 WO2000050004A2 (en) 1999-02-23 2000-02-23 Surgical anesthesia delivery system

Country Status (2)

Country Link
AU (1) AU3373500A (en)
WO (1) WO2000050004A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4820024B2 (en) * 2001-01-10 2011-11-24 昭和薬品化工株式会社 Local anesthetic composition
US8361490B2 (en) * 2004-09-16 2013-01-29 Theracoat Ltd. Biocompatible drug delivery apparatus and methods
WO2013011504A1 (en) * 2011-07-20 2013-01-24 Theracoat Ltd. Materials and method for treating internal body cavities
ITUB20155788A1 (en) * 2015-11-20 2017-05-20 Hs Hospital Service Spa COMPOSITIONS AND DEVICES FOR THE TREATMENT OF CANCER BY THERMAL ABLATION

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3624224A (en) * 1969-12-22 1971-11-30 Schering Corp Novel first aid products
US5124151A (en) * 1990-08-07 1992-06-23 Mediventures Inc. Drug delivery by injection with thermo-irreversible gels
US5587175A (en) * 1991-10-30 1996-12-24 Mdv Technologies, Inc. Medical uses of in situ formed gels
US5681576A (en) * 1988-11-16 1997-10-28 Mdv Technologies, Inc. Method and composition for post surgical adhesion reduction

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3624224A (en) * 1969-12-22 1971-11-30 Schering Corp Novel first aid products
US5681576A (en) * 1988-11-16 1997-10-28 Mdv Technologies, Inc. Method and composition for post surgical adhesion reduction
US5124151A (en) * 1990-08-07 1992-06-23 Mediventures Inc. Drug delivery by injection with thermo-irreversible gels
US5587175A (en) * 1991-10-30 1996-12-24 Mdv Technologies, Inc. Medical uses of in situ formed gels

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
A. PAAVOLA, J. YLIRUUSI, Y. KAJIMOTO: "Controlled release of lidocain from injectable gels and efficacy in rat sciatic nerve block", PHARMACEUTICAL RESEARCH, vol. 12, no. 12, 1995, pages 1997 - 2002, XP000914972 *
CHEN-CHOW P-C, FRANK S,G: "Comparison of lidocain release from pluronic F-127 gels and other formulations", ACTA PHARMACEUTICA SUECICA, vol. 18, no. 4, 1981, pages 239 - 244, XP000915005 *
CHEN-CHOW P-C, FRANK S,G: "In vitro release of lidocain from Pluronic F-127 gels", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 8, 1981, pages 89 - 99, XP000915006 *
MOHAMED A,A; ISMAIL S: "Effect of some ophtalmic vehicles on in-vivo performance of xylocaine hydrochloride in rabbits eye", PHARMAZEUTISCHE INDUSTRIE, vol. 52, no. 12, 1990, pages 1556 - 1558, XP000915004 *
PAAVOLA A; YLIRUUSI J; ROSENBERG P: "Controlled release and dura mater permeability of lidocain and ibuprofen from injectable poloxamer-based gels", JOURNAL OF CONTROLLED RELEASE, vol. 52, 1998, pages 169 - 178, XP004113665 *

Also Published As

Publication number Publication date
WO2000050004A2 (en) 2000-08-31
AU3373500A (en) 2000-09-14

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