WO2000054882A8 - Individually addressable micro-electromagnetic unit array chips - Google Patents

Individually addressable micro-electromagnetic unit array chips

Info

Publication number
WO2000054882A8
WO2000054882A8 PCT/US1999/021417 US9921417W WO0054882A8 WO 2000054882 A8 WO2000054882 A8 WO 2000054882A8 US 9921417 W US9921417 W US 9921417W WO 0054882 A8 WO0054882 A8 WO 0054882A8
Authority
WO
WIPO (PCT)
Prior art keywords
electromagnetic
chips
micro
individually addressable
biomolecules
Prior art date
Application number
PCT/US1999/021417
Other languages
French (fr)
Other versions
WO2000054882A1 (en
Inventor
Xiaoshang Zhu
Yuxiang Zhou
Litian Liu
Ken Chen
Pude Chen
Jia Wang
Zhewen Liu
Zhimin Tan
Junxuan Xu
Xuezhong He
Wenzhang Xie
Zhiming Li
Xiumei Liu
Original Assignee
Artloon Corp
Xiaoshang Zhu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Artloon Corp, Xiaoshang Zhu filed Critical Artloon Corp
Priority to DE69938742T priority Critical patent/DE69938742D1/en
Priority to CA002367698A priority patent/CA2367698C/en
Priority to EP99973783A priority patent/EP1207959B1/en
Priority to IL14545999A priority patent/IL145459A/en
Priority to JP2000604947A priority patent/JP2003521674A/en
Priority to AU60457/99A priority patent/AU6045799A/en
Priority to TW089118713A priority patent/TW496775B/en
Publication of WO2000054882A1 publication Critical patent/WO2000054882A1/en
Priority to US09/685,410 priority patent/US6716642B1/en
Publication of WO2000054882A8 publication Critical patent/WO2000054882A8/en
Priority to US10/725,160 priority patent/US20040077105A1/en

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    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
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    • CCHEMISTRY; METALLURGY
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    • GPHYSICS
    • G01MEASURING; TESTING
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    • G01N35/0098Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract

This invention provides electromagnetic chips and electromagnetic biochips having arrays of individually addressable micro-electromagnetic units, as well as methods of utilizing these chips for directed manipulation of micro-particles and micro-structures such as biomolecules and chemical reagents. An electromagnetic biochip comprises an individually addressable micro-electromagnetic unit chip with ligand molecules immobilized on its surface. By controlling the electromagnetic field at each unit of the array and combining this control with magnetic modification of biomolecules, these chips can be used for directed manipulation, synthesis and release of biomolecules in order to increase sensitivity of biochemical or chemical analysis and reduce assay time. Other advantages with these chips include minimized damages to biological molecules and increased reproducibility of assay results.
PCT/US1999/021417 1999-03-15 1999-09-17 Individually addressable micro-electromagnetic unit array chips WO2000054882A1 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
DE69938742T DE69938742D1 (en) 1999-03-15 1999-09-17 INDIVIDUALLY ADDRESSABLE MICRO ELECTROMAGNETIC UNIT MATRIX CHIP
CA002367698A CA2367698C (en) 1999-03-15 1999-09-17 Individually addressable micro-electromagnetic unit array chips
EP99973783A EP1207959B1 (en) 1999-03-15 1999-09-17 Individually addressable micro-electromagnetic unit array chips
IL14545999A IL145459A (en) 1999-03-15 1999-09-17 Individual addressable micro-electromagnetic unit array chips
JP2000604947A JP2003521674A (en) 1999-03-15 1999-09-17 Small electromagnetic unit array chip that can be individually addressed
AU60457/99A AU6045799A (en) 1999-03-15 1999-09-17 Individually addressable micro-electromagnetic unit array chips
TW089118713A TW496775B (en) 1999-03-15 2000-09-13 Individually addressable micro-electromagnetic unit array chips
US09/685,410 US6716642B1 (en) 1999-03-15 2000-10-10 Individually addressable micro-electromagnetic unit array chips in horizontal configurations
US10/725,160 US20040077105A1 (en) 1999-03-15 2003-12-01 Individually addressable micro-electromagnetic unit array chips in horizontal configurations

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN99104113 1999-03-15
CN99104113.5 1999-03-15
CN99120320.8A CN1185492C (en) 1999-03-15 1999-09-16 Single-point strobed micro electromagnetic units array chip or electromagnetic biologic chip and application thereof
CN99120320.8 1999-09-16

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US09/399,299 Continuation-In-Part US6355491B1 (en) 1999-03-15 1999-09-17 Individually addressable micro-electromagnetic unit array chips

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/685,410 Continuation-In-Part US6716642B1 (en) 1999-03-15 2000-10-10 Individually addressable micro-electromagnetic unit array chips in horizontal configurations

Publications (2)

Publication Number Publication Date
WO2000054882A1 WO2000054882A1 (en) 2000-09-21
WO2000054882A8 true WO2000054882A8 (en) 2001-02-22

Family

ID=25745003

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/021417 WO2000054882A1 (en) 1999-03-15 1999-09-17 Individually addressable micro-electromagnetic unit array chips

Country Status (10)

Country Link
US (2) US6355491B1 (en)
EP (1) EP1207959B1 (en)
JP (1) JP2003521674A (en)
CN (1) CN1185492C (en)
AT (1) ATE395137T1 (en)
AU (1) AU6045799A (en)
CA (1) CA2367698C (en)
DE (1) DE69938742D1 (en)
IL (1) IL145459A (en)
WO (1) WO2000054882A1 (en)

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