WO2000056375A3 - Mineralization and cellular patterning on biomaterial surfaces - Google Patents

Mineralization and cellular patterning on biomaterial surfaces Download PDF

Info

Publication number
WO2000056375A3
WO2000056375A3 PCT/US2000/007207 US0007207W WO0056375A3 WO 2000056375 A3 WO2000056375 A3 WO 2000056375A3 US 0007207 W US0007207 W US 0007207W WO 0056375 A3 WO0056375 A3 WO 0056375A3
Authority
WO
WIPO (PCT)
Prior art keywords
mineralization
patterned
mineralized
patterning
biomaterial surfaces
Prior art date
Application number
PCT/US2000/007207
Other languages
French (fr)
Other versions
WO2000056375A2 (en
Inventor
William L Murphy
Martin C Peters
David J Mooney
David H Kohn
Original Assignee
Univ Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan filed Critical Univ Michigan
Priority to AT00921402T priority Critical patent/ATE241397T1/en
Priority to CA2370063A priority patent/CA2370063C/en
Priority to DE60003006T priority patent/DE60003006T2/en
Priority to EP00921402A priority patent/EP1163018B1/en
Priority to AU41730/00A priority patent/AU4173000A/en
Priority to DK00921402T priority patent/DK1163018T3/en
Publication of WO2000056375A2 publication Critical patent/WO2000056375A2/en
Publication of WO2000056375A3 publication Critical patent/WO2000056375A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment

Abstract

Disclosed are advantageous methods for patterning and/or mineralizing biomaterial surfaces. The techniques described are particularly useful for generating three-dimensional or contoured bioimplant materials with patterned surfaces or patterned, mineralized surfaces. Also provided are various methods of using the mineralized and/or patterned biomaterials in tissue engineering, such as bone tissue engineering, providing more control over ongoing biological processes, such as mineralization, growth factor release, cellular attachment and tissue growth.
PCT/US2000/007207 1999-03-19 2000-03-17 Mineralization and cellular patterning on biomaterial surfaces WO2000056375A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AT00921402T ATE241397T1 (en) 1999-03-19 2000-03-17 MINERALIZATION AND CELLULAR STRUCTURING OF BIOMATERIAL SURFACES
CA2370063A CA2370063C (en) 1999-03-19 2000-03-17 Mineralization and cellular patterning on biomaterial surfaces
DE60003006T DE60003006T2 (en) 1999-03-19 2000-03-17 MINERALIZATION AND CELLULAR STRUCTURING OF BIOMATERIAL SURFACES
EP00921402A EP1163018B1 (en) 1999-03-19 2000-03-17 Mineralization and cellular patterning on biomaterial surfaces
AU41730/00A AU4173000A (en) 1999-03-19 2000-03-17 Mineralization and cellular patterning on biomaterial surfaces
DK00921402T DK1163018T3 (en) 1999-03-19 2000-03-17 Mineralization and cellular patterning on biomaterial surfaces

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12511899P 1999-03-19 1999-03-19
US60/125,118 1999-03-19
US16728999P 1999-11-24 1999-11-24
US60/167,289 1999-11-24

Publications (2)

Publication Number Publication Date
WO2000056375A2 WO2000056375A2 (en) 2000-09-28
WO2000056375A3 true WO2000056375A3 (en) 2001-01-11

Family

ID=26823278

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/007207 WO2000056375A2 (en) 1999-03-19 2000-03-17 Mineralization and cellular patterning on biomaterial surfaces

Country Status (9)

Country Link
US (2) US6541022B1 (en)
EP (1) EP1163018B1 (en)
AT (1) ATE241397T1 (en)
AU (1) AU4173000A (en)
CA (1) CA2370063C (en)
DE (1) DE60003006T2 (en)
DK (1) DK1163018T3 (en)
ES (1) ES2199815T3 (en)
WO (1) WO2000056375A2 (en)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7427602B1 (en) 1998-05-13 2008-09-23 The Regents Of The University Of Michigan Sustained DNA delivery from structural matrices
US6767928B1 (en) * 1999-03-19 2004-07-27 The Regents Of The University Of Michigan Mineralization and biological modification of biomaterial surfaces
AU4173000A (en) * 1999-03-19 2000-10-09 Regents Of The University Of Michigan, The Mineralization and cellular patterning on biomaterial surfaces
AU1622801A (en) * 1999-11-18 2001-05-30 Regents Of The University Of Michigan, The Sustained drug delivery from structural matrices
US8444958B2 (en) 2001-02-28 2013-05-21 Ezaki Glico Co., Ltd. Compositions having anti-dental caries function
AU2002251449B2 (en) * 2001-03-29 2008-01-31 Cellect Technologies Corp. Methods devices and systems for sorting and separating particles
US6703235B2 (en) * 2001-06-25 2004-03-09 Board Of Regents, The University Of Texas System Complex multicellular assemblies ex vivo
US7247609B2 (en) * 2001-12-18 2007-07-24 Universitat Zurich Growth factor modified protein matrices for tissue engineering
US6884432B2 (en) * 2002-04-25 2005-04-26 Mayo Foundation For Medical Education And Research Blend, cross-linkable poly(propylene fumarate) for immobilization and controlled drug delivery
US20040161444A1 (en) * 2002-12-18 2004-08-19 The Regents Of The University Of California Biocompatible hydrogel bone-like composites
US7309232B2 (en) * 2003-10-10 2007-12-18 Dentigenix Inc. Methods for treating dental conditions using tissue scaffolds
WO2005089127A2 (en) * 2004-03-05 2005-09-29 The Trustees Of Columbia University In The City Of New York Polymer-ceramic-hydrogel composite scaffold for osteochondral repair
EP1729675A4 (en) 2004-03-05 2011-05-18 Univ Columbia Multi-phased, biodegradable and osteointegrative composite scaffold for biological fixation of musculoskeletal soft tissue to bone
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
US7799754B2 (en) 2004-10-14 2010-09-21 Biomimetic Therapeutics, Inc. Compositions and methods for treating bone
US8071083B2 (en) * 2004-12-13 2011-12-06 Progentix Orthobiology B.V. Tissue regeneration
US8575101B2 (en) 2005-01-06 2013-11-05 Kuros Biosurgery Ag Supplemented matrices for the repair of bone fractures
US8552100B2 (en) * 2005-02-23 2013-10-08 The Regents Of The University Of California Flexible hydrogel-based functional composite materials
DE102005042707A1 (en) * 2005-09-01 2007-03-08 Polymedics Innovations Gmbh Shaped body for the medical treatment of wounds
US8936805B2 (en) 2005-09-09 2015-01-20 Board Of Trustees Of The University Of Arkansas Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same
US9763788B2 (en) 2005-09-09 2017-09-19 Board Of Trustees Of The University Of Arkansas Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same
WO2007030752A2 (en) * 2005-09-09 2007-03-15 University Of Arkansas At Little Rock System and method for tissue generation and bone regeneration
NZ571113A (en) 2005-11-17 2012-02-24 Biomimetic Therapeutics Inc Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix
EP2347775B1 (en) 2005-12-13 2020-04-15 President and Fellows of Harvard College Scaffolds for cell transplantation
KR100829452B1 (en) * 2006-06-13 2008-05-15 (주)코리아 본 뱅크 Bioactive Protein-Calcium Phosphate Composite and the Manufacturing Method of the same
US7767250B2 (en) * 2006-06-15 2010-08-03 National Research Council Of Canada Bioceramic coating of a metal-containing substrate
CN100428964C (en) * 2006-06-29 2008-10-29 武汉理工大学 Composite material of RGD polypeptide grafted poly (hydroxyacetic acid-L- lysine-L- lactic acid) / beta tricalcium phosphate, and preparation method
US9161967B2 (en) * 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
AU2007269712B2 (en) 2006-06-30 2013-02-07 Biomimetic Therapeutics, Llc PDGF-biomatrix compositions and methods for treating rotator cuff injuries
US9439948B2 (en) 2006-10-30 2016-09-13 The Regents Of The University Of Michigan Degradable cage coated with mineral layers for spinal interbody fusion
WO2010036919A1 (en) 2008-09-25 2010-04-01 Tissue Regeneration Systems, Inc. Mineral-coated microspheres
US8275594B2 (en) * 2006-10-30 2012-09-25 The Regents Of The University Of Michigan Engineered scaffolds for intervertebral disc repair and regeneration and for articulating joint repair and regeneration
US10772987B2 (en) 2006-10-30 2020-09-15 Trs Holdings Llc Mineral coated scaffolds
AU2007333425B2 (en) 2006-11-03 2014-03-27 Biomimetic Therapeutics, Llc Compositions and methods for arthrodetic procedures
US20100047309A1 (en) * 2006-12-06 2010-02-25 Lu Helen H Graft collar and scaffold apparatuses for musculoskeletal tissue engineering and related methods
US20090287309A1 (en) 2007-01-30 2009-11-19 Tornier Sas Intra-articular joint replacement
FR2911773B1 (en) * 2007-01-30 2009-03-27 Tornier Sas METHOD AND ASSEMBLY OF SURGICAL INSTRUMENTATION FOR POSITIONING A TOTAL REVERSE SHOULDER PROSTHESIS, AND CORRESPONDING PROSTHESIS
US20080195476A1 (en) * 2007-02-09 2008-08-14 Marchese Michael A Abandonment remarketing system
US8753391B2 (en) 2007-02-12 2014-06-17 The Trustees Of Columbia University In The City Of New York Fully synthetic implantable multi-phased scaffold
EP2064324B1 (en) * 2007-02-22 2011-04-06 Corning Incorporated Substrates useful for cell culture and methods for making and using same
WO2009002401A2 (en) 2007-06-21 2008-12-31 President And Fellows Of Harvard College Scaffolds for cell collection or elimination
US8075562B2 (en) * 2007-06-25 2011-12-13 Wisconsin Alumni Research Foundation Controlled release of biopharmaceutical growth factors from hydroxyapatite coating on bioresorbable interference screws used in cruciate ligament reconstruction surgery
US20090286907A1 (en) * 2008-01-23 2009-11-19 Beltz Mark W Fumaric Acid/Diol Polyesters and Their Manufacture and Use
CN102014977B (en) * 2008-02-07 2015-09-02 生物模拟治疗有限责任公司 For compositions and the method for Distraction Osteogenesis
US9370558B2 (en) 2008-02-13 2016-06-21 President And Fellows Of Harvard College Controlled delivery of TLR agonists in structural polymeric devices
JP5690143B2 (en) 2008-02-13 2015-03-25 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ Continuous cell programming device
WO2009146456A1 (en) * 2008-05-30 2009-12-03 President And Fellows Of Harvard College Controlled release of growth factors and signaling molecules for promoting angiogenesis
US10842645B2 (en) 2008-08-13 2020-11-24 Smed-Ta/Td, Llc Orthopaedic implant with porous structural member
WO2010019781A1 (en) 2008-08-13 2010-02-18 Smed-Ta/Td, Llc Drug delivery implants
JP5774989B2 (en) 2008-08-13 2015-09-09 スメド−ティーエイ／ティーディー・エルエルシー Orthopedic screw
US9700431B2 (en) 2008-08-13 2017-07-11 Smed-Ta/Td, Llc Orthopaedic implant with porous structural member
US9616205B2 (en) 2008-08-13 2017-04-11 Smed-Ta/Td, Llc Drug delivery implants
ES2686906T3 (en) 2008-08-29 2018-10-22 Smed-Ta/Td, Llc Orthopedic implant
EP2341951A2 (en) * 2008-09-09 2011-07-13 BioMimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries
CA2754501A1 (en) * 2009-03-05 2010-09-10 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods for the treatment of osteochondral defects
US9297005B2 (en) 2009-04-13 2016-03-29 President And Fellows Of Harvard College Harnessing cell dynamics to engineer materials
CA2768552A1 (en) 2009-07-31 2011-02-03 President And Fellows Of Harvard College Programming of cells for tolerogenic therapies
US8492339B2 (en) * 2009-10-26 2013-07-23 Empire Technology Development Llc Angiogenesis promoted by caged growth factors
JP6144049B2 (en) 2010-02-22 2017-06-07 バイオミメティック セラピューティクス，リミテッド ライアビリティ カンパニー Platelet-derived growth factor compositions and methods for treating tendon disorders
EP2542230A4 (en) 2010-03-05 2013-08-28 Harvard College Enhancement of skeletal muscle stem cell engrafment by dual delivery of vegf and igf-1
US9408652B2 (en) 2010-04-27 2016-08-09 Tornier Sas Intra-articular joint replacement and method
WO2011163669A2 (en) 2010-06-25 2011-12-29 President And Fellows Of Harvard College Co-delivery of stimulatory and inhibitory factors to create temporally stable and spatially restricted zones
WO2012027218A2 (en) 2010-08-27 2012-03-01 Corning Incorporated Peptide-modified surfaces for cell culture
CN107648668B (en) 2010-10-06 2021-06-18 哈佛学院董事会 Injectable pore-forming hydrogels for material-based cell therapy
US9603894B2 (en) 2010-11-08 2017-03-28 President And Fellows Of Harvard College Materials presenting notch signaling molecules to control cell behavior
US9200271B2 (en) 2011-02-03 2015-12-01 Empire Technology Development Llc Selective 3D biopatterning
ES2882852T3 (en) 2011-03-16 2021-12-02 Kuros Biosurgery Ag Pharmaceutical formulation for use in spinal fusion
WO2012148684A1 (en) 2011-04-27 2012-11-01 President And Fellows Of Harvard College Cell-friendly inverse opal hydrogels for cell encapsulation, drug and protein delivery, and functional nanoparticle encapsulation
ES2685327T3 (en) 2011-04-28 2018-10-08 President And Fellows Of Harvard College Injectable preformed macroscopic three-dimensional frames for minimally invasive administration
US9675561B2 (en) 2011-04-28 2017-06-13 President And Fellows Of Harvard College Injectable cryogel vaccine devices and methods of use thereof
WO2012167230A1 (en) 2011-06-03 2012-12-06 President And Fellows Of Harvard College In situ antigen-generating cancer vaccine
WO2012176023A1 (en) 2011-06-23 2012-12-27 Indian Institute Of Technology Kanpur Hydrogel scaffolds for tissue engineering
US8753309B2 (en) 2011-06-24 2014-06-17 The Invention Science Fund I, Llc Device, system, and method including micro-patterned cell treatment array
EP3662896B1 (en) 2012-04-16 2024-02-28 President and Fellows of Harvard College Mesoporous silica compositions for modulating immune responses
WO2014169249A1 (en) 2013-04-12 2014-10-16 The Trustees Of Columbia University In The City Of New York Methods for host cell homing and dental pulp regeneration
DE102013217085A1 (en) * 2013-08-27 2015-03-05 Gilupi Gmbh Method for improving the biocompatibility of a surface
JP7348708B2 (en) 2014-04-30 2023-09-21 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ Combination vaccine device and method for killing cancer cells
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
US11786457B2 (en) 2015-01-30 2023-10-17 President And Fellows Of Harvard College Peritumoral and intratumoral materials for cancer therapy
AU2016226095B2 (en) 2015-03-03 2020-07-09 Trs Holdings Llc Coating scaffolds
EP3280464A4 (en) 2015-04-10 2018-09-26 President and Fellows of Harvard College Immune cell trapping devices and methods for making and using the same
CN115487351A (en) 2016-02-06 2022-12-20 哈佛学院校长同事会 Remodeling hematopoietic niches to reconstitute immunity
MA45738A (en) 2016-07-13 2019-05-22 Harvard College MIMETIC SCAFFOLDING OF ANTIGEN PRESENT CELLS AND METHODS FOR PREPARING AND USING THEM
EP3630151A4 (en) * 2017-05-30 2021-04-28 Stem Pharm, Incorporated Visible light polymerization of polyethylene glycol (peg) hydrogels
US11747269B2 (en) 2021-11-09 2023-09-05 Warsaw Orthopedic, Inc. Systems and methods for identifying a coating on an implant
US20230142212A1 (en) 2021-11-09 2023-05-11 Warsaw Orthopedic, Inc. Systems and methods of coating bone material

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0679373A2 (en) * 1994-04-28 1995-11-02 Advanced Cardiovascular Systems, Inc. Intravascular prosthesis with anti-thrombogenic coating
US5510628A (en) * 1987-03-06 1996-04-23 Geo-Centers, Inc. Deep ultraviolet photolithographically defined ultra-thin films for selective cell adhesion and outgrowth and method of manufacturing the same and devices containing the same
US5807406A (en) * 1994-10-07 1998-09-15 Baxter International Inc. Porous microfabricated polymer membrane structures
WO1998044027A1 (en) * 1997-03-31 1998-10-08 The Regents Of The University Of Michigan Open pore biodegradable matrices
US5855802A (en) * 1996-05-30 1999-01-05 International Business Machines Corporation Method and apparatus for forming a tubular article having a perforated annular wall
EP0891783A1 (en) * 1997-07-16 1999-01-20 Isotis B.V. Device for tissue engineering bone comprising biodegradable thermoplastic copolyester and cultured cells

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4636526A (en) 1985-02-19 1987-01-13 The Dow Chemical Company Composites of unsintered calcium phosphates and synthetic biodegradable polymers useful as hard tissue prosthetics
US5266480A (en) 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
US4933185A (en) 1986-09-24 1990-06-12 Massachusetts Institute Of Technology System for controlled release of biologically active compounds
US5759830A (en) 1986-11-20 1998-06-02 Massachusetts Institute Of Technology Three-dimensional fibrous scaffold containing attached cells for producing vascularized tissue in vivo
CA1340581C (en) 1986-11-20 1999-06-08 Joseph P. Vacanti Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices
US5041138A (en) 1986-11-20 1991-08-20 Massachusetts Institute Of Technology Neomorphogenesis of cartilage in vivo from cell culture
JPS63270061A (en) 1987-04-28 1988-11-08 Hoya Corp Surface modification of inorganic bio-compatible material
US5011691A (en) 1988-08-15 1991-04-30 Stryker Corporation Osteogenic devices
US5965079A (en) * 1995-04-25 1999-10-12 3D Systems, Inc. Method and apparatus for making a three-dimensional object by stereolithography
US4996120A (en) * 1988-12-29 1991-02-26 E. I. Dupont De Nemours And Company Holographic photopolymer compositions and elements containing a ring-opening monomer
DE69013764T2 (en) 1989-06-03 1995-03-30 Kanegafuchi Chemical Ind Control of cell arrangement.
US5529914A (en) * 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
US5491198A (en) 1992-02-24 1996-02-13 Clemson University Process for phosphonylating the surface of an organic polymeric preform
US5558517A (en) 1992-02-24 1996-09-24 Clemson University Polymeric prosthesis having a phosphonylated surface
US5334640A (en) * 1992-04-08 1994-08-02 Clover Consolidated, Ltd. Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods
US5330799A (en) * 1992-09-15 1994-07-19 The Phscologram Venture, Inc. Press polymerization of lenticular images
US5514378A (en) * 1993-02-01 1996-05-07 Massachusetts Institute Of Technology Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures
CN1245156C (en) * 1993-02-22 2006-03-15 美国生物科学有限公司 Methods for in vivo delivery of biologics and compositions useful therefor
CA2160878A1 (en) 1993-04-19 1994-10-27 Sandra Gertrude Mcelligott Encapsulation of nucleic acids with conjugates that facilitate and target cellular uptake and gene expression
US5876454A (en) * 1993-05-10 1999-03-02 Universite De Montreal Modified implant with bioactive conjugates on its surface for improved integration
US5512131A (en) 1993-10-04 1996-04-30 President And Fellows Of Harvard College Formation of microstamped patterns on surfaces and derivative articles
US5776748A (en) 1993-10-04 1998-07-07 President And Fellows Of Harvard College Method of formation of microstamped patterns on plates for adhesion of cells and other biological materials, devices and uses therefor
WO1995019796A1 (en) * 1994-01-21 1995-07-27 Brown University Research Foundation Biocompatible implants
US5942496A (en) 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
US5962427A (en) 1994-02-18 1999-10-05 The Regent Of The University Of Michigan In vivo gene transfer methods for wound healing
US5763416A (en) 1994-02-18 1998-06-09 The Regent Of The University Of Michigan Gene transfer into bone cells and tissues
US5641391A (en) * 1995-05-15 1997-06-24 Hunter; Ian W. Three dimensional microfabrication by localized electrodeposition and etching
US5654381A (en) 1995-06-16 1997-08-05 Massachusetts Institute Of Technology Functionalized polyester graft copolymers
US5965125A (en) * 1995-10-25 1999-10-12 Transkaryotic Therapies, Inc. Hybrid matrix implants and explants
ATE402994T1 (en) 1995-11-06 2008-08-15 Mount Sinai Hospital Corp RECONSTITUTED MINERALIZED CARTILAGE TISSUE
US5830539A (en) * 1995-11-17 1998-11-03 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Methods for functionalizing and coating substrates and devices made according to the methods
US6033719A (en) 1996-04-25 2000-03-07 Medtronic, Inc. Method for covalent attachment of biomolecules to surfaces of medical devices
US5785965A (en) 1996-05-15 1998-07-28 The Board Of Trustees Of The Leland Stanford Junior Univ. VEGF gene transfer into endothelial cells for vascular prosthesis
WO1997045533A1 (en) 1996-05-28 1997-12-04 The Regents Of The University Of Michigan Engineering oral tissues
US6143037A (en) 1996-06-12 2000-11-07 The Regents Of The University Of Michigan Compositions and methods for coating medical devices
US6210707B1 (en) * 1996-11-12 2001-04-03 The Regents Of The University Of California Methods of forming protein-linked lipidic microparticles, and compositions thereof
WO1998041189A1 (en) * 1997-03-20 1998-09-24 Therics, Inc. Fabrication of tissue products using a mold formed by solid free-form methods
WO1999001538A1 (en) * 1997-07-03 1999-01-14 Massachusetts Institute Of Technology Tissue-engineered constructs
US6077987A (en) * 1997-09-04 2000-06-20 North Shore-Long Island Jewish Research Institute Genetic engineering of cells to enhance healing and tissue regeneration
US6391311B1 (en) 1998-03-17 2002-05-21 Genentech, Inc. Polypeptides having homology to vascular endothelial cell growth factor and bone morphogenetic protein 1
US5925069A (en) * 1997-11-07 1999-07-20 Sulzer Intermedics Inc. Method for preparing a high definition window in a conformally coated medical device
US6187329B1 (en) 1997-12-23 2001-02-13 Board Of Regents Of The University Of Texas System Variable permeability bone implants, methods for their preparation and use
WO1999044538A1 (en) 1998-01-27 1999-09-10 The Regents Of The University Of California Biodegradable polymer/protein based coils for intralumenal implants
ATE275977T1 (en) * 1998-04-13 2004-10-15 Massachusetts Inst Technology COMB POLYMERS FOR REGULATING CELL SURFACE INTERACTION
WO1999058656A2 (en) 1998-05-13 1999-11-18 The Regents Of The University Of Michigan Sustained dna delivery from structural matrices
US6767928B1 (en) * 1999-03-19 2004-07-27 The Regents Of The University Of Michigan Mineralization and biological modification of biomaterial surfaces
AU4173000A (en) * 1999-03-19 2000-10-09 Regents Of The University Of Michigan, The Mineralization and cellular patterning on biomaterial surfaces
US6200646B1 (en) * 1999-08-25 2001-03-13 Spectra Group Limited, Inc. Method for forming polymeric patterns, relief images and colored polymeric bodies using digital light processing technology

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510628A (en) * 1987-03-06 1996-04-23 Geo-Centers, Inc. Deep ultraviolet photolithographically defined ultra-thin films for selective cell adhesion and outgrowth and method of manufacturing the same and devices containing the same
EP0679373A2 (en) * 1994-04-28 1995-11-02 Advanced Cardiovascular Systems, Inc. Intravascular prosthesis with anti-thrombogenic coating
US5807406A (en) * 1994-10-07 1998-09-15 Baxter International Inc. Porous microfabricated polymer membrane structures
US5855802A (en) * 1996-05-30 1999-01-05 International Business Machines Corporation Method and apparatus for forming a tubular article having a perforated annular wall
WO1998044027A1 (en) * 1997-03-31 1998-10-08 The Regents Of The University Of Michigan Open pore biodegradable matrices
EP0891783A1 (en) * 1997-07-16 1999-01-20 Isotis B.V. Device for tissue engineering bone comprising biodegradable thermoplastic copolyester and cultured cells

Also Published As

Publication number Publication date
DE60003006D1 (en) 2003-07-03
CA2370063A1 (en) 2000-09-28
EP1163018B1 (en) 2003-05-28
US6541022B1 (en) 2003-04-01
DK1163018T3 (en) 2003-09-29
WO2000056375A2 (en) 2000-09-28
DE60003006T2 (en) 2004-04-01
ATE241397T1 (en) 2003-06-15
AU4173000A (en) 2000-10-09
CA2370063C (en) 2012-10-02
US20030203002A1 (en) 2003-10-30
EP1163018A2 (en) 2001-12-19
ES2199815T3 (en) 2004-03-01

Similar Documents

Publication Publication Date Title
WO2000056375A3 (en) Mineralization and cellular patterning on biomaterial surfaces
WO2001054746A3 (en) Composite biomaterial including anisometric calcium phosphate reinforcement particles
AU2002307791A1 (en) Composite scaffolds and methods using same for generating complex tissue grafts
AU2003275684A1 (en) Apatite/collagen crosslinked porous material containing self-organized apatite/collagen composite and process for producing the same
AU7511200A (en) Resorbable bone replacement and bone formation material
WO2003011184A8 (en) Adventitial fabric reinforced porous prosthetic graft
IL147974A0 (en) Composite shaped bodies and methods for their production and use
WO1999062424A3 (en) Bioengineered tubular graft prostheses
AU2001247455A1 (en) Locking hip prosthesis
WO2003035127A1 (en) Organic/inorganic composite biomaterials and processes for producing the same
DE69921526D1 (en) Bipolar hip prosthesis with locking head
WO2000045867A8 (en) Implant comprising calcium cement and hydrophobic liquid
DE69917391D1 (en) Prosthesis with a gripping system in the bone
AU4497700A (en) Prosthetic grafts
AU2443799A (en) Method for treating materials, especially biological tissues, using light induction and device for realising the same
AU4950099A (en) Material for bone reconstruction
AU1615000A (en) Transmyocardial implant with coronary ingrowth
AU2002224141A1 (en) Tissue equivalant for transplantation and process for producing the same
AU6424800A (en) Long fibre-reinforced thermoplastic material and method for producing the same
AU2776199A (en) Treating wastes, preparing construction materials and stabilizing
AU2345297A (en) Composite sheet for artificial leather
EP1150684A4 (en) Anti-resorptive bone cements and allogeneic, autografic, and xenografic bone grafts
EP1277482A3 (en) Mineralization and cellular patterning on biomaterial surfaces
AU2938897A (en) Hollow bone mineral-like calcium phosphate particles
EP1000902A4 (en) Hydroxyapatite, composite, processes for producing these, and use of these

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2000921402

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2370063

Country of ref document: CA

Ref country code: CA

Ref document number: 2370063

Kind code of ref document: A

Format of ref document f/p: F

WWP Wipo information: published in national office

Ref document number: 2000921402

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWG Wipo information: grant in national office

Ref document number: 2000921402

Country of ref document: EP