WO2000066066A3 - Method and devices for creating a trap for confining therapeutic drugs and/or genes in the myocardium - Google Patents

Method and devices for creating a trap for confining therapeutic drugs and/or genes in the myocardium Download PDF

Info

Publication number
WO2000066066A3
WO2000066066A3 PCT/US2000/012156 US0012156W WO0066066A3 WO 2000066066 A3 WO2000066066 A3 WO 2000066066A3 US 0012156 W US0012156 W US 0012156W WO 0066066 A3 WO0066066 A3 WO 0066066A3
Authority
WO
WIPO (PCT)
Prior art keywords
myocardium
confining
trap
creating
devices
Prior art date
Application number
PCT/US2000/012156
Other languages
French (fr)
Other versions
WO2000066066A2 (en
Inventor
Marvin P Loeb
Original Assignee
Cardiodyne Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardiodyne Inc filed Critical Cardiodyne Inc
Publication of WO2000066066A2 publication Critical patent/WO2000066066A2/en
Publication of WO2000066066A3 publication Critical patent/WO2000066066A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0067Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0082Catheter tip comprising a tool
    • A61M25/0084Catheter tip comprising a tool being one or more injection needles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/06Body-piercing guide needles or the like
    • A61M25/0662Guide tubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0067Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0082Catheter tip comprising a tool
    • A61M25/0084Catheter tip comprising a tool being one or more injection needles
    • A61M2025/0089Single injection needle protruding axially, i.e. along the longitudinal axis of the catheter, from the distal tip
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/58Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/587Lighting arrangements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00Anatomical parts of the body
    • A61M2210/12Blood circulatory system
    • A61M2210/125Heart

Abstract

Devices and methods for effective administration of therapeutic drugs or gene therapy to the myocardium is achieved by creating a trap or pocket within the myocardium for confining the injected therapeutic. The pocket can be created using mechanical and light energy, or other means.
PCT/US2000/012156 1999-05-04 2000-05-04 Method and devices for creating a trap for confining therapeutic drugs and/or genes in the myocardium WO2000066066A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/305,129 1999-05-04
US09/305,129 US6224566B1 (en) 1999-05-04 1999-05-04 Method and devices for creating a trap for confining therapeutic drugs and/or genes in the myocardium

Publications (2)

Publication Number Publication Date
WO2000066066A2 WO2000066066A2 (en) 2000-11-09
WO2000066066A3 true WO2000066066A3 (en) 2001-04-19

Family

ID=23179466

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/012156 WO2000066066A2 (en) 1999-05-04 2000-05-04 Method and devices for creating a trap for confining therapeutic drugs and/or genes in the myocardium

Country Status (2)

Country Link
US (2) US6224566B1 (en)
WO (1) WO2000066066A2 (en)

Families Citing this family (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6723082B1 (en) * 1995-05-10 2004-04-20 Sam G. Payne Delivery catheter system for heart chamber
US7187822B2 (en) * 1995-08-31 2007-03-06 Biolase Technology, Inc. Fiber tip fluid output device
JP3930052B2 (en) * 1996-02-15 2007-06-13 バイオセンス・インコーポレイテッド Catheter-based surgery
US6532387B1 (en) 1999-03-26 2003-03-11 Kevin S. Marchitto Catheter for delivering electromagnetic energy for enhanced permeation of substances
US6389313B1 (en) * 1999-03-26 2002-05-14 Kevin S. Marchitto Laser probes for drug permeation
WO2000067825A1 (en) * 1999-05-07 2000-11-16 Microheart, Inc. Apparatus and method for delivering therapeutic and diagnostic agents
US20040147912A1 (en) * 1999-08-25 2004-07-29 Cardiofocus, Inc. Surgical ablation system with sliding ablation device
AU3885801A (en) * 1999-09-20 2001-04-24 Stereotaxis, Inc. Magnetically guided myocardial treatment system
US6599274B1 (en) * 2000-01-20 2003-07-29 John Kucharczyk Cell delivery catheter and method
US6695836B1 (en) * 2000-07-03 2004-02-24 Radius Medical Technologies, Inc. Device and method for myocardial revascularization
US6638249B1 (en) * 2000-07-17 2003-10-28 Wisconsin Alumni Research Foundation Ultrasonically actuated needle pump system
US6811562B1 (en) * 2000-07-31 2004-11-02 Epicor, Inc. Procedures for photodynamic cardiac ablation therapy and devices for those procedures
DE60124574T2 (en) * 2000-09-12 2007-06-21 Law, Peter K., Richmond Hill CATHETER FOR MYOGENIC CELL TRANSFER
US20040138621A1 (en) * 2003-01-14 2004-07-15 Jahns Scott E. Devices and methods for interstitial injection of biologic agents into tissue
US6508783B2 (en) * 2001-03-14 2003-01-21 Scimed Life Systems, Inc. Ultrasound method for revascularization and drug delivery
US20040082940A1 (en) * 2002-10-22 2004-04-29 Michael Black Dermatological apparatus and method
US20030216719A1 (en) * 2001-12-12 2003-11-20 Len Debenedictis Method and apparatus for treating skin using patterns of optical energy
US6740107B2 (en) * 2001-12-19 2004-05-25 Trimedyne, Inc. Device for treatment of atrioventricular valve regurgitation
US7169127B2 (en) * 2002-02-21 2007-01-30 Boston Scientific Scimed, Inc. Pressure apron direct injection catheter
US7798815B2 (en) * 2002-04-03 2010-09-21 University Of The West Indies Computer-controlled tissue-based simulator for training in cardiac surgical techniques
US7108685B2 (en) * 2002-04-15 2006-09-19 Boston Scientific Scimed, Inc. Patch stabilization of rods for treatment of cardiac muscle
AU2003239353A1 (en) * 2002-05-14 2003-12-02 Arryx, Inc. Broad spectrum optically addressed sensor
US9474577B2 (en) * 2002-10-23 2016-10-25 Ardent Medical Corporation Ablation cannula and kit with insert
US6902526B2 (en) * 2002-10-23 2005-06-07 Orthopaedic Development, Llc Visualizing ablation device and procedure
US20050021091A1 (en) * 2003-04-23 2005-01-27 Laske Timothy G. System for the delivery of a biologic therapy with device monitoring and back-up
DE10334516B4 (en) * 2003-07-29 2006-06-14 Sorin Group Deutschland Gmbh Display and operating device for medical devices and display / control unit therefor
US7840263B2 (en) 2004-02-27 2010-11-23 Cardiac Pacemakers, Inc. Method and apparatus for device controlled gene expression
US8349001B2 (en) 2004-04-07 2013-01-08 Medtronic, Inc. Pharmacological delivery implement for use with cardiac repair devices
US7764995B2 (en) 2004-06-07 2010-07-27 Cardiac Pacemakers, Inc. Method and apparatus to modulate cellular regeneration post myocardial infarct
US7604830B2 (en) * 2004-06-24 2009-10-20 Cook Incorporated Method and apparatus for coating interior surfaces of medical devices
US7828711B2 (en) * 2004-08-16 2010-11-09 Cardiac Pacemakers, Inc. Method and apparatus for modulating cellular growth and regeneration using ventricular assist device
US20060122584A1 (en) * 2004-10-27 2006-06-08 Bommannan D B Apparatus and method to treat heart disease using lasers to form microchannels
US8060219B2 (en) 2004-12-20 2011-11-15 Cardiac Pacemakers, Inc. Epicardial patch including isolated extracellular matrix with pacing electrodes
US7981065B2 (en) 2004-12-20 2011-07-19 Cardiac Pacemakers, Inc. Lead electrode incorporating extracellular matrix
US8109981B2 (en) * 2005-01-25 2012-02-07 Valam Corporation Optical therapies and devices
DE102005017204B4 (en) * 2005-04-14 2012-03-22 Lisa Laser Products Ohg Fuhrberg & Teichmann Endoscope and method for introducing an optical fiber into a working channel of an endoscope
US20070021653A1 (en) * 2005-06-27 2007-01-25 Lars-Olof Hattenbach Device for the injection of drugs into microvessels
ATE375808T1 (en) * 2005-06-27 2007-11-15 Lars-Olof Hattenbach DEVICE FOR INJECTING MEDICATIONS INTO MICRO VESSELS
US9238150B2 (en) * 2005-07-22 2016-01-19 The Board Of Trustees Of The Leland Stanford Junior University Optical tissue interface method and apparatus for stimulating cells
US20070053996A1 (en) 2005-07-22 2007-03-08 Boyden Edward S Light-activated cation channel and uses thereof
US8926959B2 (en) 2005-07-22 2015-01-06 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US9274099B2 (en) 2005-07-22 2016-03-01 The Board Of Trustees Of The Leland Stanford Junior University Screening test drugs to identify their effects on cell membrane voltage-gated ion channel
US10052497B2 (en) 2005-07-22 2018-08-21 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US8182444B2 (en) * 2005-11-04 2012-05-22 Medrad, Inc. Delivery of agents such as cells to tissue
US7713232B2 (en) 2005-11-04 2010-05-11 Medrad, Inc. System for washing and processing of cells for delivery thereof to tissue
US20090048577A1 (en) * 2006-01-09 2009-02-19 University Of Virginia Patent Foundation Multi-Port Catheter System with Medium Control and Measurement Systems for Therapy and Diagnosis Delivery
US7949408B2 (en) * 2006-04-28 2011-05-24 Medtronic, Inc. System and method for electrically probing and providing medical electrical stimulation
US9511214B2 (en) 2006-05-02 2016-12-06 Vascular Access Technologies, Inc. Methods of transvascular retrograde access placement and devices for facilitating therein
US7874991B2 (en) * 2006-06-23 2011-01-25 Teratech Corporation Ultrasound 3D imaging system
US20080086111A1 (en) * 2006-10-09 2008-04-10 Medrad, Inc. Fluid delivery systems and volume metering in cell delivery
US20080108979A1 (en) * 2006-11-03 2008-05-08 William Telfair Flush Tip Illuminating Laser Probe Treatment Apparatus
US7787950B1 (en) * 2006-11-03 2010-08-31 Pacesetter, Inc. Techniques for delivery of stem cell and related therapies to treat cardiac conditions
WO2008086470A1 (en) 2007-01-10 2008-07-17 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US8401609B2 (en) 2007-02-14 2013-03-19 The Board Of Trustees Of The Leland Stanford Junior University System, method and applications involving identification of biological circuits such as neurological characteristics
WO2008106694A2 (en) 2007-03-01 2008-09-04 The Board Of Trustees Of The Leland Stanford Junior University Systems, methods and compositions for optical stimulation of target cells
US7682089B2 (en) * 2007-08-15 2010-03-23 Rohlen Brooks H System and method for positioning a probe
US10434327B2 (en) 2007-10-31 2019-10-08 The Board Of Trustees Of The Leland Stanford Junior University Implantable optical stimulators
US10035027B2 (en) 2007-10-31 2018-07-31 The Board Of Trustees Of The Leland Stanford Junior University Device and method for ultrasonic neuromodulation via stereotactic frame based technique
ES2608498T3 (en) 2008-04-23 2017-04-11 The Board Of Trustees Of The Leland Stanford Junior University Systems, methods and compositions for optical stimulation of target cells
SG191604A1 (en) 2008-06-17 2013-07-31 Univ Leland Stanford Junior Apparatus and methods for controlling cellular development
US9101759B2 (en) 2008-07-08 2015-08-11 The Board Of Trustees Of The Leland Stanford Junior University Materials and approaches for optical stimulation of the peripheral nervous system
US20120179044A1 (en) 2009-09-30 2012-07-12 Alice Chiang Ultrasound 3d imaging system
US10080544B2 (en) * 2008-09-15 2018-09-25 Teratech Corporation Ultrasound 3D imaging system
NZ602416A (en) 2008-11-14 2014-08-29 Univ Leland Stanford Junior Optically-based stimulation of target cells and modifications thereto
US8409236B2 (en) * 2009-08-21 2013-04-02 Vascular Access Technologies, Inc. Methods of transvascular retrograde access placement and devices for facilitating the placement
AU2010318562B2 (en) * 2009-11-11 2013-11-21 Alcon Inc. Structured illumination probe and method
AU2010319912B2 (en) * 2009-11-11 2014-10-02 Alcon Inc. Structured illumination probe and method
US10206742B2 (en) * 2010-02-21 2019-02-19 C Laser, Inc. Fiber embedded hollow spikes for percutaneous delivery of laser energy
US10537725B2 (en) * 2010-03-05 2020-01-21 Cornell University Ultrasound-assisted convection enhanced delivery of compounds in vivo with a transducer cannula assembly
CA2791094A1 (en) 2010-03-17 2011-09-22 The Board Of Trustees Of The Leland Stanford Junior University Light-sensitive ion-passing molecules
ES2453200T3 (en) * 2010-08-24 2014-04-04 Homag Holzbearbeitungssysteme Ag Transmission device for radiation
WO2012061744A2 (en) 2010-11-05 2012-05-10 The Board Of Trustees Of The Leland Stanford Junior University Stabilized step function opsin proteins and methods of using the same
US9992981B2 (en) 2010-11-05 2018-06-12 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic control of reward-related behaviors
CN103313752B (en) 2010-11-05 2016-10-19 斯坦福大学托管董事会 Upper conversion for the light of light genetic method
AU2011323237B2 (en) 2010-11-05 2015-11-12 The Board Of Trustees Of The Leland Stanford Junior University Optically-controlled CNS dysfunction
US10086012B2 (en) 2010-11-05 2018-10-02 The Board Of Trustees Of The Leland Stanford Junior University Control and characterization of memory function
CN103492564B (en) 2010-11-05 2017-04-19 斯坦福大学托管董事会 Light-activated chimeric opsins and methods of using the same
US8696722B2 (en) 2010-11-22 2014-04-15 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic magnetic resonance imaging
US9204862B2 (en) 2011-07-08 2015-12-08 General Electric Company Method and apparatus for performing ultrasound elevation compounding
JP6230996B2 (en) * 2011-08-01 2017-11-15 アルキオーネ・ライフサイエンシズ・インコーポレイテッドAlcyone Lifesciences, Inc. Microfluidic drug delivery device
JP6406581B2 (en) 2011-12-16 2018-10-17 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー Opsin polypeptides and uses thereof
WO2013126521A1 (en) 2012-02-21 2013-08-29 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for treating neurogenic disorders of the pelvic floor
US20130281859A1 (en) * 2012-04-23 2013-10-24 General Electric Company Ultrasound imaging system and method
WO2013181397A1 (en) 2012-05-30 2013-12-05 Vascular Access Technologies, Inc. Transvascular access device and method
US9623217B2 (en) 2012-05-30 2017-04-18 Vascular Access Techonlogies, Inc. Transvascular access methods
AU2013361601B2 (en) 2012-12-18 2018-04-19 Alcyone Therapeutics, Inc. Systems and methods for reducing or preventing backflow in a delivery system
JP6594854B2 (en) 2013-03-15 2019-10-23 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー Optogenetic control of behavioral state
US9636380B2 (en) 2013-03-15 2017-05-02 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic control of inputs to the ventral tegmental area
EP2991491B1 (en) 2013-04-29 2019-12-25 The Board of Trustees of the Leland Stanford Junior University Devices, systems and methods for optogenetic modulation of action potentials in target cells
AU2014281682B2 (en) 2013-06-17 2019-03-21 Alcyone Therapeutics, Inc. Methods and devices for protecting catheter tips and stereotactic fixtures for microcatheters
US9504522B2 (en) * 2013-06-25 2016-11-29 Biosense Webster (Israel) Ltd. Electrocardiogram noise reduction
CA2920014C (en) 2013-07-31 2021-11-09 Alcyone Lifesciences, Inc. Systems and methods for drug delivery, treatment, and monitoring
JP6621747B2 (en) 2013-08-14 2019-12-18 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー Compositions and methods for controlling pain
US9655524B2 (en) 2013-09-13 2017-05-23 Novartis Ag OCT probe with bowing flexor
US9517014B2 (en) * 2013-09-16 2016-12-13 Novartis Ag OCT probe with pivoting fiber
US10470712B2 (en) 2014-06-19 2019-11-12 Sipple Medical, Llc Biomarker detection and identification system and apparatus
US10806396B2 (en) 2015-01-26 2020-10-20 Alcyone Lifesciences, Inc. Drug delivery methods with tracer
US10568516B2 (en) 2015-06-22 2020-02-25 The Board Of Trustees Of The Leland Stanford Junior University Methods and devices for imaging and/or optogenetic control of light-responsive neurons
US11179545B2 (en) * 2015-10-12 2021-11-23 Swaminathan Jayaraman System and method for delivery of therapeutic agent through a catheter
CN108472019A (en) 2016-01-04 2018-08-31 亚克安娜生命科学有限公司 Method and apparatus for treating apoplexy
CN108495589A (en) * 2016-01-25 2018-09-04 富士胶片株式会社 Insert and attachment component
US10617854B2 (en) 2016-12-09 2020-04-14 Vascular Access Technologies, Inc. Trans-jugular carotid artery access methods
US11654224B2 (en) 2016-12-30 2023-05-23 Vascular Access Technologies, Inc. Methods and devices for percutaneous implantation of arterio-venous grafts
US11294165B2 (en) 2017-03-30 2022-04-05 The Board Of Trustees Of The Leland Stanford Junior University Modular, electro-optical device for increasing the imaging field of view using time-sequential capture
JP6752373B2 (en) * 2017-09-15 2020-09-09 富士フイルム株式会社 Inserts, optical inserts and photoacoustic measuring devices
CN109124809B (en) * 2018-09-19 2023-09-01 贵州医科大学附属医院 Neonatal suckling mouse myocardial infarction model puncture outfit
CN110339434A (en) * 2019-08-20 2019-10-18 中国人民解放军总医院 A kind of three microcatheter devices and method for ultrasound guidance through chest transexocardial intramyocardial injection
CN110339433A (en) * 2019-08-20 2019-10-18 中国人民解放军总医院 A kind of three puncture needle device and method for ultrasound guidance through chest transexocardial intramyocardial injection
WO2023154908A2 (en) * 2022-02-11 2023-08-17 Board Of Regents, The University Of Texas System Convection-enhanced thermo-chemotherapy catheter system

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840059A (en) * 1995-06-07 1998-11-24 Cardiogenesis Corporation Therapeutic and diagnostic agent delivery
US5843073A (en) * 1985-07-31 1998-12-01 Rare Earth Medical, Inc. Infrared laser catheter system
US5861020A (en) * 1994-12-09 1999-01-19 Schwarzmaier; Hans-Joachim Apparatus for irradiating body tissue with laser light
US5872879A (en) * 1996-11-25 1999-02-16 Boston Scientific Corporation Rotatable connecting optical fibers
US5891133A (en) * 1996-03-29 1999-04-06 Eclipse Surgical Technologies, Inc. Apparatus for laser-assisted intra-coronary transmyocardial revascularization and other applications

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4773413A (en) 1983-06-13 1988-09-27 Trimedyne Laser Systems, Inc. Localized heat applying medical device
US5532143A (en) 1987-08-07 1996-07-02 The Medical Research Council Isolated DNA molecules for intergration site independent gene expression in mammalian host cells
US5328470A (en) 1989-03-31 1994-07-12 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
US5698531A (en) 1989-03-31 1997-12-16 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
US5849572A (en) 1990-10-10 1998-12-15 Regents Of The University Of Michigan HSV-1 vector containing a lat promoter
US5389096A (en) 1990-12-18 1995-02-14 Advanced Cardiovascular Systems System and method for percutaneous myocardial revascularization
US5685820A (en) * 1990-11-06 1997-11-11 Partomed Medizintechnik Gmbh Instrument for the penetration of body tissue
US5380316A (en) 1990-12-18 1995-01-10 Advanced Cardiovascular Systems, Inc. Method for intra-operative myocardial device revascularization
US5242438A (en) 1991-04-22 1993-09-07 Trimedyne, Inc. Method and apparatus for treating a body site with laterally directed laser radiation
US5607401A (en) * 1991-09-03 1997-03-04 Humphrey; Bruce H. Augmented polymeric hypodermic devices
US5661133B1 (en) 1991-11-12 1999-06-01 Univ Michigan Collateral blood vessel formation in cardiac muscle by injecting a dna sequence encoding an angiogenic protein
FR2714830B1 (en) 1994-01-10 1996-03-22 Rhone Poulenc Rorer Sa Composition containing nucleic acids, preparation and uses.
GB9425600D0 (en) 1994-12-19 1995-02-15 Medical Res Council Targeting complexes and use thereof
US5792453A (en) 1995-02-28 1998-08-11 The Regents Of The University Of California Gene transfer-mediated angiogenesis therapy
US5837511A (en) 1995-10-02 1998-11-17 Cornell Research Foundation, Inc. Non-group C adenoviral vectors
US5999678A (en) * 1996-12-27 1999-12-07 Eclipse Surgical Technologies, Inc. Laser delivery means adapted for drug delivery
US5876373A (en) * 1997-04-04 1999-03-02 Eclipse Surgical Technologies, Inc. Steerable catheter
US5964757A (en) * 1997-09-05 1999-10-12 Cordis Webster, Inc. Steerable direct myocardial revascularization catheter

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843073A (en) * 1985-07-31 1998-12-01 Rare Earth Medical, Inc. Infrared laser catheter system
US5861020A (en) * 1994-12-09 1999-01-19 Schwarzmaier; Hans-Joachim Apparatus for irradiating body tissue with laser light
US5840059A (en) * 1995-06-07 1998-11-24 Cardiogenesis Corporation Therapeutic and diagnostic agent delivery
US5891133A (en) * 1996-03-29 1999-04-06 Eclipse Surgical Technologies, Inc. Apparatus for laser-assisted intra-coronary transmyocardial revascularization and other applications
US5872879A (en) * 1996-11-25 1999-02-16 Boston Scientific Corporation Rotatable connecting optical fibers

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US20010023346A1 (en) 2001-09-20
WO2000066066A2 (en) 2000-11-09

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