WO2000066274A1 - Device for producing foamed sclerosing agent - Google Patents

Device for producing foamed sclerosing agent Download PDF

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Publication number
WO2000066274A1
WO2000066274A1 PCT/ES2000/000159 ES0000159W WO0066274A1 WO 2000066274 A1 WO2000066274 A1 WO 2000066274A1 ES 0000159 W ES0000159 W ES 0000159W WO 0066274 A1 WO0066274 A1 WO 0066274A1
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WO
WIPO (PCT)
Prior art keywords
rod
container
outlet
sclerosant
head
Prior art date
Application number
PCT/ES2000/000159
Other languages
Spanish (es)
French (fr)
Inventor
Francisco Javier Garcia Mingo
Original Assignee
Francisco Javier Garcia Mingo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Francisco Javier Garcia Mingo filed Critical Francisco Javier Garcia Mingo
Publication of WO2000066274A1 publication Critical patent/WO2000066274A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/0018—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas with devices for making foam
    • B05B7/0025—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas with devices for making foam with a compressed gas supply
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/24—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas with means, e.g. a container, for supplying liquid or other fluent material to a discharge device
    • B05B7/2402—Apparatus to be carried on or by a person, e.g. by hand; Apparatus comprising containers fixed to the discharge device
    • B05B7/2405—Apparatus to be carried on or by a person, e.g. by hand; Apparatus comprising containers fixed to the discharge device using an atomising fluid as carrying fluid for feeding, e.g. by suction or pressure, a carried liquid from the container to the nozzle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491—Surgical glue applicators

Definitions

  • the invention that concerns us concerns a device for producing foam sclerosants from liquid sclerosants, which are intended to simplify this type of device.
  • Foamed sclerosant is used in the treatment of varicose veins, in which it is injected.
  • the device for producing foamed sclerosant of the invention is characterized in that it has a container in which the sclerosing liquid is deposited from which the foamed sclerosant is produced.
  • the container is provided with connection means to a source of impeller gas, which are preferably located at the base thereof.
  • the container is hermetically sealed by a head in which a small diameter probe tube that runs along the inside of the container is fixed.
  • a valve In correspondence with the end of the probe tube, and in the head itself, a valve has been arranged whose actuation communicates the output of the probe tube with an outlet conduit disposed in the head, the application of the sclerosant being foamed.
  • gas is injected inside the container to a certain pressure, so that when the valve is actuated, the foam sclerosant exits through the outlet duct and through the probe tube, which reduces the pressure of exit.
  • the valve is determined by a rod assisted by a spring that runs transversely to the head, from which it protrudes and is finished off by a push button.
  • the rod is equipped with two channels perimetrics in which o-rings are retained between which the outlet of the probe tube is located, so that when the button is pressed the outlet of the probe tube is released allowing the passage of the foamed sclerosant from the probe tube to the exit of the head.
  • valve can be implemented by any type of manually operated closure.
  • the means of connecting the container to a source of impeller gas are determined by a quick connector, type fitting or by a direct threaded connection connector.
  • FIGURES Figure 1. Shows a perspective view of a possible embodiment of the invention.
  • Figure 2. Shows a bottom view of the device for producing foamed sclerosant of the previous figure.
  • Figure 3. Shows a sectional view of the device of the invention to clearly show the internal structure of the device of the invention.
  • the device to produce sclerosant Foaming of the invention has a container 1 and a head 2 in which a probe tube 3 is fixed by threading, which through a conical section 4 communicates with a housing 6 of a rod 7.
  • the head 2 seals the container 1 tightly by an O-ring 5, so that the probe tube runs along the inside of the container 1.
  • the rod is assisted by a spring 8 and includes a stop 9 that prevents it from being removed from the housing.
  • the rod 7 goes outside the head 2 and is finished off by a push button 10.
  • the rod 10 is removable for what is secured by means of a bushing 19 which is screwed to the head 2.
  • the rod 7 has two o-rings 11 and 12 housed in a perimeter channel, between which the probe tube 3 is arranged.
  • the rod 7 has a third perimeter channel in which a third O-ring 13 is retained.
  • the housing 6 of the rod 7 communicates with an outlet duct 14 which is presented as an extension or neck of the head 2 to enable the connection of the conventional ducts or means of distribution of the foamed product such as a body 15 that It includes a key 16 for opening and closing the outlet of the sclerosing product to a tube 17, as will be explained later.
  • a connector 18 is included in the lower base of the container 1 to connect a source of impeller gas such as liquid air, helium, oxygen, etc.
  • the container 1 is filled with the sclerosing liquid, and then sealed with the head 2.
  • the impeller gas is injected into the container 1 until it reaches a certain pressure, so that if in this circumstance the button 10 is actuated, overcoming the action of the spring 8, the displacement of the rod 7 and consequently the displacement of the o-rings 11, 12 and 13, so that the outlet of the probe tube, instead of being located between the o-rings 11 and 12, is located between the o-rings 12 and 13 so that the connection of the outlet duct 14, through the housing 6, with the probe tube 3 through which the foamed sclerosant runs due to the pressure inside the container 1, pressure which is reduced by the small inner diameter of the tube probe 3 and goes outside through the outlet conduit 14, from which it is carried by tube 17 to the varicose vein in which it is injected.
  • the spring action forces the rod to be placed in its initial position in which the outlet of the probe tube 3 is located between the o-rings 11 and 12, so that the foam sclerosant outlet through outlet duct 14.
  • the probe tube 3 is internally covered by a copper tube, so in the section of Figure 3 a double path is seen.

Abstract

The device includes a container (1) in which the sclerosing liquid is deposited, in addition to connecting means (18) to a propellant gas source. Said container is hermetically closed by a head piece (2) in which a small diameter probe tube (3) is inserted to reduce pressure, said tube extending inside the container (1) and being closed by a valve (7, 8, 10, 11, 12 and 13) whose actuation causes the outflow of the foamed sclerosing agent through an outlet (14) provided in the head piece (2) as a result of the propellant gas.

Description

DISPOSITIVO PARA PRODUCIR ESCLEROSANTE ESPUMADO OBJETO DE LA INVENCIÓN DEVICE FOR PRODUCING SLUMPING FOAMED OBJECT OF THE INVENTION
La invención que nos ocupa, se refiere a un dispositivo para producir esclerosantes en espuma partiendo de esclerosantes líquidos, que tienen por objeto simplificar este tipo de dispositivos.The invention that concerns us concerns a device for producing foam sclerosants from liquid sclerosants, which are intended to simplify this type of device.
El esclerosante espumado se emplea en el tratamiento de varices, en las que se inyecta.Foamed sclerosant is used in the treatment of varicose veins, in which it is injected.
DESCRIPCIÓN DE LA INVENCIÓN El dispositivo para producir esclerosante espumado de la invención, se caracteriza porque cuenta con un contenedor en el que se deposita el liquido esclerosante a partir del cual se produce el esclerosante espumado.DESCRIPTION OF THE INVENTION The device for producing foamed sclerosant of the invention is characterized in that it has a container in which the sclerosing liquid is deposited from which the foamed sclerosant is produced.
El contenedor está dotado de medios de conexión a una fuente de gas impulsor, que preferentemente están situados en la base del mismo.The container is provided with connection means to a source of impeller gas, which are preferably located at the base thereof.
Además el contenedor es obturado herméticamente por un cabezal en el que se fija un tubo sonda de pequeño diámetro que discurre a lo largo del interior del contenedor.In addition, the container is hermetically sealed by a head in which a small diameter probe tube that runs along the inside of the container is fixed.
En correspondencia con el extremo del tubo sonda, y en el propio cabezal, se ha dispuesto una válvula cuyo accionamiento comunica la salida del tubo sonda con un conducto de salida dispuesto en el cabezal, facultándose la aplicación del esclerosante en espuma.In correspondence with the end of the probe tube, and in the head itself, a valve has been arranged whose actuation communicates the output of the probe tube with an outlet conduit disposed in the head, the application of the sclerosant being foamed.
Para conseguir esta funcionalidad se inyecta gas en el interior del contenedor hasta una determinada presión, de forma que al ser actuada la válvula, se produce la salida del esclerosante espumado por el conducto de salida y a través del tubo sonda, el cual reduce la presión de salida.To achieve this functionality, gas is injected inside the container to a certain pressure, so that when the valve is actuated, the foam sclerosant exits through the outlet duct and through the probe tube, which reduces the pressure of exit.
Ventajosamente la válvula está determinada por un vastago asistido por un resorte que discurre transver- salmente al cabezal, del que sobresale y se remata en un pulsador. Además el vastago está dotado de dos canales perimétricos en los que se retienen sendas juntas tóricas entre las que queda ubicada la salida del tubo sonda, de modo que al presionar el pulsador la salida del tubo sonda es liberada permitiéndose el paso del esclerosante espumado desde el tubo sonda hacia la salida del cabezal.Advantageously, the valve is determined by a rod assisted by a spring that runs transversely to the head, from which it protrudes and is finished off by a push button. In addition the rod is equipped with two channels perimetrics in which o-rings are retained between which the outlet of the probe tube is located, so that when the button is pressed the outlet of the probe tube is released allowing the passage of the foamed sclerosant from the probe tube to the exit of the head.
Tras accionar el pulsador y facultar la salida del esclerosante espumoso, se impide que éste salga al exterior a través del alojamiento del vastago, mediante una tercera junta tórica ubicada en un tercer canal perimétrico del vastago que impide la salida del esclerosante espumoso.After pressing the button and enabling the exit of the sparkling sclerosant, it is prevented from leaving the outside through the rod housing, by means of a third O-ring located in a third perimetric channel of the rod that prevents the exit of the sparkling sclerosant.
Evidentemente la válvula puede implementarse por cualquier tipo de cierre accionable manualmente.Obviously the valve can be implemented by any type of manually operated closure.
Los medios de conexión del contenedor a una fuente de gas impulsor están determinados por un conector rápido, tipo racor o por un conector de conexión directa por roscado.The means of connecting the container to a source of impeller gas are determined by a quick connector, type fitting or by a direct threaded connection connector.
A continuación para facilitar una mejor comprensión de esta memoria descriptiva y formando parte integrante de la misma, se acompañan una serie de figuras en las que con carácter ilustrativo y no limitativo se ha representado el objeto de la invención.Next, in order to facilitate a better understanding of this descriptive report and forming an integral part thereof, a series of figures are attached in which the object of the invention has been represented by way of illustration and not limitation.
BREVE ENUNCIADO DE LAS FIGURAS Figura 1.- Muestra una vista en perspectiva de un posible ejemplo de realización de la invención. Figura 2.- Muestra una vista inferior del dispositivo para producir esclerosante espumado de la figura anterior.BRIEF STATEMENT OF THE FIGURES Figure 1.- Shows a perspective view of a possible embodiment of the invention. Figure 2.- Shows a bottom view of the device for producing foamed sclerosant of the previous figure.
Figura 3.- Muestra una vista seccionada del dispositivo de la invención para mostrar claramente la estructura interna del dispositivo de la invención.Figure 3.- Shows a sectional view of the device of the invention to clearly show the internal structure of the device of the invention.
DESCRIPCIÓN DE LA FORMA DE REALIZACIÓN PREFERIDADESCRIPTION OF THE PREFERRED EMBODIMENT
A continuación se realiza una descripción de la invención basada en las figuras anteriormente comentadas. Así el dispositivo para producir esclerosante espumado de la invención cuenta con un contenedor 1 y un cabezal 2 en el que se fija, por roscado, un tubo sonda 3 que a través de un tramo cónico 4 se comunica con un alojamiento 6 de un vastago 7. El cabezal 2 obtura al contenedor 1 herméticamente mediante una junta tórica 5, de modo que el tubo sonda discurre a lo largo del interior del contenedor 1.Below is a description of the invention based on the figures mentioned above. Thus the device to produce sclerosant Foaming of the invention has a container 1 and a head 2 in which a probe tube 3 is fixed by threading, which through a conical section 4 communicates with a housing 6 of a rod 7. The head 2 seals the container 1 tightly by an O-ring 5, so that the probe tube runs along the inside of the container 1.
El vastago es asistido por un resorte 8 e incluye un tope 9 que impide que pueda ser extraído del alojamiento.The rod is assisted by a spring 8 and includes a stop 9 that prevents it from being removed from the housing.
El vastago 7 sale al exterior del cabezal 2 y se remata mediante un pulsador 10.The rod 7 goes outside the head 2 and is finished off by a push button 10.
En una realización preferente el vastago 10 es desmontable para lo que queda sujeto mediante un casquillo 19 que se fija por roscado al cabezal 2.In a preferred embodiment, the rod 10 is removable for what is secured by means of a bushing 19 which is screwed to the head 2.
Además el vastago 7 cuenta con dos juntas tóricas 11 y 12 alojadas en un canal perimétrico, entre las que queda dispuesto el tubo sonda 3. El vastago 7 cuenta con un tercer canal perimétrico en el que se retiene una tercera junta tórica 13.In addition, the rod 7 has two o-rings 11 and 12 housed in a perimeter channel, between which the probe tube 3 is arranged. The rod 7 has a third perimeter channel in which a third O-ring 13 is retained.
El alojamiento 6 del vastago 7 se comunica con un conducto de salida 14 que se presenta como una prolongación o cuello del cabezal 2 para facultar la conexión de los conductos o medios convencionales de distribución del producto espumado como puede ser el caso de un cuerpo 15 que incluye una llave 16 de apertura y cierre de salida del producto esclerosante a un tubo 17, tal y como será explicado con posterioridad.The housing 6 of the rod 7 communicates with an outlet duct 14 which is presented as an extension or neck of the head 2 to enable the connection of the conventional ducts or means of distribution of the foamed product such as a body 15 that It includes a key 16 for opening and closing the outlet of the sclerosing product to a tube 17, as will be explained later.
En la base inferior del contenedor 1 se incluye un conector 18 para conectar una fuente de gas impulsor como puede ser aire liquido, helio, oxígeno, etc.In the lower base of the container 1 a connector 18 is included to connect a source of impeller gas such as liquid air, helium, oxygen, etc.
Para conseguir el correcto funcionamiento de la estructura descrita, una vez abierto el contenedor 1, éste se llena con el líquido esclerosante, y a continuación se cierra herméticamente con el cabezal 2. En este punto se inyecta el gas impulsor en el interior del contenedor 1 hasta que alcanza una determinada presión, de forma que si en esta circunstancia se actúa sobre el pulsador 10, venciendo la acción del resorte 8, se produce el desplazamiento del vastago 7 y consecuentemente el desplazamiento de las juntas tóricas 11, 12 y 13, de modo que la salida del tubo sonda, en lugar de quedar ubicada entre las juntas tóricas 11 y 12, se ubica entre las juntas tóricas 12 y 13 de forma que se produce la conexión del conducto de salida 14, a través del alojamiento 6, con el tubo sonda 3 por el cual discurre el esclerosante espumado por la presión que hay en el interior del contenedor 1, presión que es reducida por el pequeño diámetro interior que presenta el tubo sonda 3 y sale al exterior mediante el conducto de salida 14, a partir del cual es llevado por el tubo 17 hasta la variz en la que se inyecta .In order to achieve the correct operation of the described structure, once the container 1 is opened, it is filled with the sclerosing liquid, and then sealed with the head 2. At this point, the impeller gas is injected into the container 1 until it reaches a certain pressure, so that if in this circumstance the button 10 is actuated, overcoming the action of the spring 8, the displacement of the rod 7 and consequently the displacement of the o-rings 11, 12 and 13, so that the outlet of the probe tube, instead of being located between the o-rings 11 and 12, is located between the o-rings 12 and 13 so that the connection of the outlet duct 14, through the housing 6, with the probe tube 3 through which the foamed sclerosant runs due to the pressure inside the container 1, pressure which is reduced by the small inner diameter of the tube probe 3 and goes outside through the outlet conduit 14, from which it is carried by tube 17 to the varicose vein in which it is injected.
Una vez que se deja de actuar sobre el pulsador 10, la acción del resorte obliga a situarse al vastago en su posición inicial en la que la salida del tubo sonda 3 queda ubicado entre las juntas tóricas 11 y 12, de manera que se impide la salida del esclerosante espumado a través del conducto de salida 14.Once the button 10 is stopped acting, the spring action forces the rod to be placed in its initial position in which the outlet of the probe tube 3 is located between the o-rings 11 and 12, so that the foam sclerosant outlet through outlet duct 14.
En el ejemplo de realización el tubo sonda 3 está recubierto internamente por un tubo de cobre por lo que en la sección de la figura 3 se ve un doble trazado. In the exemplary embodiment, the probe tube 3 is internally covered by a copper tube, so in the section of Figure 3 a double path is seen.

Claims

REIVINDICACIONES; 1.- DISPOSITIVO PARA PRODUCIR ESCLEROSANTE ESPUMADO, de preferente aplicación para tratar varices, se caracteriza porque cuenta con un contenedor (1), en el que se deposita líquido esclerosante, que además está dotado de medios de conexión (18) a una fuente de gas impulsor, y que es obturado herméticamente por un cabezal (2) en el que se fija un tubo sonda (3) de pequeño diámetro para reducir la presión, que discurre a lo largo del interior del contenedor (1) y que es obturado por una válvula cuyo accionamiento provoca la salida del esclerosante espumado por un conducto de salida (14) previsto en el propio cabezal, y todo ello por la acción del gas. CLAIMS; 1.- DEVICE FOR PRODUCING FOAM SCLEROSANT, preferably applied to treat varicose veins, is characterized in that it has a container (1), in which sclerosing liquid is deposited, which is also provided with connection means (18) to a source of impeller gas, and which is sealed tightly by a head (2) in which a probe tube (3) of small diameter is fixed to reduce the pressure, which runs along the inside of the container (1) and which is sealed by a valve whose actuation causes the foam sclerosant to exit through an outlet duct (14) provided in the head itself, and all this by the action of the gas.
2.- DISPOSITIVO PARA PRODUCIR ESCLEROSANTE ESPUMADO, según reivindicación 1, caracterizado porque la válvula está determinada por un vastago (7) asistido por un resorte (8) que, a través de un alojamiento (6), discurre transversalmente al cabezal (2), del que sobresale y se remata en un pulsador (10); incluyendo el vastago (7) dos canales perimétricos en los que se retienen sendas juntas tóricas (11 y 12) entre las que queda ubicada la salida del tubo sonda (3), de modo que al presionar el pulsador (10), la salida del tubo sonda (3) se comunica con el conducto de salida (14) a través del alojamiento (6) del vastago (7) permitiéndose el paso del esclerosante espumado hacia la salida del cabezal.2. DEVICE FOR PRODUCING FOAMED SLOSTER, according to claim 1, characterized in that the valve is determined by a rod (7) assisted by a spring (8) which, through a housing (6), runs transversely to the head (2) , which protrudes and ends in a button (10); including the rod (7) two perimetric channels in which two O-rings (11 and 12) are retained between which the outlet of the probe tube (3) is located, so that when pressing the button (10), the outlet of the probe tube (3) communicates with the outlet duct (14) through the housing (6) of the rod (7) allowing the sclerosant foaming to the head outlet.
3.- DISPOSITIVO PARA PRODUCIR ESCLEROSANTE ESPUMADO, según reivindicación 2, caracterizado porque el vastago ( 7 ) cuenta con un tercer canal perimétrico de retención de una tercera junta tórica (13) que impide la salida del esclerosante espumado al exterior a través del alojamiento (6) del vastago (7), cuando se deja de presionar el pulsador (10). 3. DEVICE FOR PRODUCING FOAMED SLOSTER, according to claim 2, characterized in that the rod (7) has a third perimetric retaining channel of a third O-ring (13) that prevents the exit of the foamy sclerosant to the outside through the housing ( 6) of the rod (7), when the button (10) is stopped pressing.
PCT/ES2000/000159 1999-05-03 2000-04-28 Device for producing foamed sclerosing agent WO2000066274A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES9901133U ES1043183Y (en) 1999-05-03 1999-05-03 DEVICE FOR PRODUCING FOAMED SCLEROSANT.
ESU9901133 1999-05-03

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WO2000066274A1 true WO2000066274A1 (en) 2000-11-09

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WO (1) WO2000066274A1 (en)

Cited By (11)

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WO2002041872A1 (en) 2000-11-24 2002-05-30 Btg International Limited Generation of therapeutic microfoam
USRE38919E1 (en) 1993-06-23 2005-12-13 Btg International Limited Injectable microfoam containing a sclerosing agent
US7025290B2 (en) 1999-05-26 2006-04-11 Btg International Limited Generation of therapeutic microfoam
US7731986B2 (en) 2003-11-17 2010-06-08 Btg International Ltd. Therapeutic foam
US7814943B2 (en) 2003-09-10 2010-10-19 Btg International Limited Apparatus and method for dispensing foam
US8048439B2 (en) 2003-11-17 2011-11-01 Btg International Ltd. Therapeutic foam
US8512680B2 (en) 2001-08-08 2013-08-20 Btg International Ltd. Injectables in foam, new pharmaceutical applications
US8703827B2 (en) 2005-05-13 2014-04-22 Btg International Ltd. Therapeutic foam
WO2015185554A2 (en) 2014-06-03 2015-12-10 Enrique Roche Rebollo Methods, devices, systems and kits for preparing compositions for care and repair of varicose veins
CN108785807A (en) * 2018-04-13 2018-11-13 闫焕利 A kind of disposable oxygen atomization inhalator applied to neonate department
CN109414258A (en) * 2016-07-26 2019-03-01 普罗文西斯有限公司 Method and apparatus for generating injectable foam

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US3752368A (en) * 1971-10-12 1973-08-14 H Robertson Airless liquid spraying device
US3945379A (en) * 1974-08-08 1976-03-23 Smithkline Corporation Injection device

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Publication number Priority date Publication date Assignee Title
GB1119143A (en) * 1965-01-08 1968-07-10 Pierre Bret Improvements in or relating to fluid dispensers
US3752368A (en) * 1971-10-12 1973-08-14 H Robertson Airless liquid spraying device
US3945379A (en) * 1974-08-08 1976-03-23 Smithkline Corporation Injection device

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE38919E1 (en) 1993-06-23 2005-12-13 Btg International Limited Injectable microfoam containing a sclerosing agent
USRE40640E1 (en) 1993-06-23 2009-02-17 Btg International Ltd. Injectable microfoam containing a sclerosing agent
US8091801B2 (en) 1999-05-26 2012-01-10 Btg International Limited Generation of therapeutic microfoam
US7025290B2 (en) 1999-05-26 2006-04-11 Btg International Limited Generation of therapeutic microfoam
US7357336B2 (en) 1999-05-26 2008-04-15 Btg International Limited Generation of therapeutic microfoam
US7604185B2 (en) 1999-05-26 2009-10-20 Btg International Ltd. Generation of therapeutic microfoam
US7842282B2 (en) 2000-11-24 2010-11-30 Btg International Limited Generation of therapeutic microfoam
EP1337238B2 (en) † 2000-11-24 2017-01-25 BTG International Limited Generation of therapeutic microfoam
US7842283B2 (en) 2000-11-24 2010-11-30 Btg International Limited Generation of therapeutic microfoam
WO2002041872A1 (en) 2000-11-24 2002-05-30 Btg International Limited Generation of therapeutic microfoam
US8512680B2 (en) 2001-08-08 2013-08-20 Btg International Ltd. Injectables in foam, new pharmaceutical applications
US8122917B2 (en) 2003-09-10 2012-02-28 Btg International Limited Apparatus and method for dispensing foam
US7814943B2 (en) 2003-09-10 2010-10-19 Btg International Limited Apparatus and method for dispensing foam
US7731986B2 (en) 2003-11-17 2010-06-08 Btg International Ltd. Therapeutic foam
US7763269B2 (en) 2003-11-17 2010-07-27 Btg International Ltd. Therapeutic foam
US8323677B2 (en) 2003-11-17 2012-12-04 Btg International Ltd. Therapeutic foam
US8048439B2 (en) 2003-11-17 2011-11-01 Btg International Ltd. Therapeutic foam
US8703827B2 (en) 2005-05-13 2014-04-22 Btg International Ltd. Therapeutic foam
WO2015185554A2 (en) 2014-06-03 2015-12-10 Enrique Roche Rebollo Methods, devices, systems and kits for preparing compositions for care and repair of varicose veins
US10688452B2 (en) 2014-06-03 2020-06-23 Vascular Barcelona Devices, S.L. Methods, devices, systems and kits for preparing compositions for care and repair of varicose veins
CN109414258A (en) * 2016-07-26 2019-03-01 普罗文西斯有限公司 Method and apparatus for generating injectable foam
CN108785807A (en) * 2018-04-13 2018-11-13 闫焕利 A kind of disposable oxygen atomization inhalator applied to neonate department

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