WO2000068137A1 - Apparatus for automatic preparation of a mixture and method - Google Patents

Apparatus for automatic preparation of a mixture and method Download PDF

Info

Publication number
WO2000068137A1
WO2000068137A1 PCT/US2000/012229 US0012229W WO0068137A1 WO 2000068137 A1 WO2000068137 A1 WO 2000068137A1 US 0012229 W US0012229 W US 0012229W WO 0068137 A1 WO0068137 A1 WO 0068137A1
Authority
WO
WIPO (PCT)
Prior art keywords
flow channel
receptacle
mixture
fluent
vessels
Prior art date
Application number
PCT/US2000/012229
Other languages
French (fr)
Inventor
Edwin D. Neas
Dennis L. Templar
Harry J. Tiffany, Iii
Original Assignee
Neas Edwin D
Templar Dennis L
Tiffany Harry J Iii
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neas Edwin D, Templar Dennis L, Tiffany Harry J Iii filed Critical Neas Edwin D
Priority to US10/030,659 priority Critical patent/US6793387B1/en
Priority to AU51263/00A priority patent/AU5126300A/en
Publication of WO2000068137A1 publication Critical patent/WO2000068137A1/en

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20Measuring; Control or regulation
    • B01F35/21Measuring
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/26Methods or devices for controlling the quantity of the material fed or filled
    • B65B3/30Methods or devices for controlling the quantity of the material fed or filled by volumetric measurement
    • B65B3/32Methods or devices for controlling the quantity of the material fed or filled by volumetric measurement by pistons co-operating with measuring chambers
    • B65B3/326Methods or devices for controlling the quantity of the material fed or filled by volumetric measurement by pistons co-operating with measuring chambers for dosing several products to be mixed
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80Mixing plants; Combinations of mixers
    • B01F33/84Mixing plants with mixing receptacles receiving material dispensed from several component receptacles, e.g. paint tins
    • B01F33/841Mixing plants with mixing receptacles receiving material dispensed from several component receptacles, e.g. paint tins with component receptacles fixed in a circular configuration on a horizontal table, e.g. the table being able to be indexed about a vertical axis
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/06Mixing of food ingredients
    • B01F2101/14Mixing of ingredients for non-alcoholic beverages; Dissolving sugar in water
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/2204Mixing chemical components in generals in order to improve chemical treatment or reactions, independently from the specific application
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/24Mixing of ingredients for cleaning compositions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/30Mixing paints or paint ingredients, e.g. pigments, dyes, colours, lacquers or enamel
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20Measuring; Control or regulation

Definitions

  • the present invention relates to the preparation of mixtures including liquid reagents, cleaning and other special-purpose solutions, solvents, pesticides, herbicides, paints, mixed beverages, fluent foodstuff, as well as other fluent substances used in the laboratory, manufacturing plant floor, field crops, gardens, eating establishments, building structures, art lab, and so on.
  • mixtures including liquid reagents, cleaning and other special-purpose solutions, solvents, pesticides, herbicides, paints, mixed beverages, fluent foodstuff, as well as other fluent substances used in the laboratory, manufacturing plant floor, field crops, gardens, eating establishments, building structures, art lab, and so on.
  • the invention relates to the automation of such mixture preparation using a novel apparatus, whether the constituent components are uniformly distributed within the mixture.
  • This apparatus and associated method utilizes a unique automated technique to , in accordance with input concerning a desired end-product, select at least one of a plurality of available fluent constituent components staged on a support structure, dose/measure a requisite amount of each selected constituent component, collect the dosed amount with mixing receptacle, and agitate/stir the collected contents in the receptacle to prepare the preselected end-product.
  • a processor and storage device are readily adapted to collect and store data concerning the preparation, as desired.
  • the footprint of the apparatus can be chosen for portability. And although a variety of vessels containing constituent components can be made of rigid or brittle materials, a support structure of the apparatus is adaptable for the arrangement of gravity fed, 'bag-like' flexible walled vessels.
  • a versatile automatic, less labor-intensive and less error-prone process is needed.
  • a process is carried out using a computerized apparatus designed to be generally portable, with a footprint that can accommodate the limited available counter top space found in most laboratories, manufacturing environments, and eating establishments.
  • the innovative apparatus and method described herein utilize a unique sophisticated technique to automatically: (a) access, dispense, and dose appropriate quantities of selected ingredients held in containment vessels in proximity to one another, this being done according to input entered through some type of user interface as well as a plurality of instructions/commands stored for automatic retrieval into computer memory, and (b) collect each such ingredient into a receptacle (such as a flask, beaker, etc.) for mixing and auto-titration (as desired).
  • a receptacle such as a flask, beaker, etc.
  • the new apparatus and associated method require much less intervention by a lab technician, line worker, etc. and provides sufficient production quality control over batch sizes of hundreds of flasks of prepared mixtures.
  • many different types of suitable alternative structures for carrying out specified function(s) may be incorporated into the new apparatus and method of the invention.
  • the incorporation of flexible-walled vessels ('bag-type') having novel features invented by certain of the listed applicant-inventors hereof, and assigned to the assignee hereof, helps address problems associated with cumbersome transport and storage of heavy, breakable ceramic (e.g. , glass) hard- walled containers.
  • These unique flexible-walled vessels can be fabricated from many suitable materials into many different shapes and sizes, and filled with countless different types of fluent substance ingredients as needed for preparing desired mixtures.
  • the first flow channel of each vessel is in further communication with a dedicated measurement assembly, for dosmg fluent substance so dispensed, and a second flow channel.
  • the apparatus also includes a receptacle support; and can further incorporate a user interface for receiving a first input concerning the mixture plus a storage device to hold instructions for locatmg a respective one of the second flow channels and the receptacle support in operative relation (for collecting the fluent substance in a mixture receptacle placed on the receptacle support).
  • the apparatus can further comprise titration and mixing modules; and an alternative apparatus and method can utilize a support structure havmg a framework moveably coupled to a sustaining member, whereby many flexible-walled vessels can be accommodated.
  • An apparatus of the invention can stage a multitude of constituent fluent ingredients (including solvents, buffers/reagents, homogeneous and non- homogeneous solutions, titrants, including reactants, etc.) for access and dispensing dependmg on the mstructions/commands and mput received for the preparation of the preselected mixture.
  • the apparatus can be driven by its own power source (especially important for the field), or connected to an external source of power such as line voltage from an electrical wall oudet.
  • the invention includes an apparatus for automatic preparation of a preselected mixture, comprising: a plurality of vessels, each vessel arranged on a support structure and oriented for dispensing a fluent substance through at least one exit port and a first flow channel.
  • Each of the first flow channels is in further communication with a dedicated measurement assembly and a second flow channel.
  • the apparatus also has a receptacle support, a user interface for receiving a first input concerning the mixture, and a storage device holding a plurality of instructions for locating a respective one of the second flow channels and the receptacle support in operative relation for collecting the fluent substance.
  • the mixtures which can be prepared utilizing the invention include liquid reagents , cleaning and other special-purpose solutions, solvents, pesticides, herbicides, paints, mixed beverages, fluent foodstuff, as well as other fluent substances used in the laboratory, manufacturing plant floor, field crops, gardens, eating establishments, building structures, art lab, and so on.
  • the support structure comprises a framework moveably coupled to a sustaining member; (b) a dose actuator stationed in positional relationship with the receptacle support; (c) the vessels having been hermetically formed of flexible stock material into a 'bag-type' shape; (d) mixing and titration modules; and (e) further instructions on the storage device can include: instructions for dispensing from the first flow channel the requisite amount of fluent substance from a respective vessel; instructions for directing a respective one of the dedicated measurement devices to dose the fluent substance so dispensed; instructions for rotating, or otherwise moving/sliding/positiomng/placing, a respective one of the vessels and/or an associated dedicated measurement assembly and/or the receptacle support, to position a respective second flow channel above the receptacle support; instructions for automatically mixmg and/or titrating, including any type of analysis/reaction performed on or to, substances collected in
  • the invention also includes a method of preparing a preselected mixture using a computerized apparatus, including the steps of (a) receiving a first input concerning the mixture; and (b) according to the first input and a plurality of instructions held on a storage device of the apparatus: automatically locating a second flow channel and a receptacle support in operative relation; dispensing a fluent substance through at least one exit port and a first flow channel from a respective one of a plurality of vessels arranged on a suppo ⁇ structure of the apparatus, each of the first flow channels in further communication with a dedicated measurement assembly and a second flow channel; and using the measurement assembly, dosing the fluent substance so dispensed.
  • FIG. 1 diagrammatically illustrates features of a preferred apparatus 10 of the invention.
  • FIG. 2 is an isometric of a preferred apparatus 30 detailing further structural features.
  • FIG. 3 is an isometric of an alternative apparatus labeled 50, with shroud 41 removed and certain other features slightly altered.
  • FIG. 4 is a side view of the alternative apparatus 50 in FIG. 3.
  • FIG. 5A is a schematic side view representation of the apparatus 50 illustrating many of the features shown in FIG. 4, in further detail.
  • FIG. 5B is a schematic top view of an alternative apparatus 100 to show representative locations of certain of the features.
  • FIG. 6 is an isometric illustrating a preferred flexible- walled vessel 130 of the invention in use alongside laboratory-type equipment supported by an alternative framework.
  • FIGs. 7A, 7B, and 7C are schematic representation (two side views and a top view, respectively) of an alternative apparatus 250, again detailing certain features of the invention.
  • FIG. 8 is a flow diagram detailing preferred steps, in an expanded novel manner, of a method 300 of preparing a preselected mixture using a unique apparatus of the invention.
  • the apparatus of the invention 10 is shown with several appropriately sized vessels labeled 14a - 14f in fluent communication 18a- 18f with a spout or collection channel 19 and into a receptacle 20.
  • each vessel is filled with the fluent substance ingredient and arranged for dispensing along a respective channel 18a- 18f according to amount of use throughout the period of operation.
  • Vessels can be made of made of any sturdy flexible-walled or other material (e.g. , a glass or other ceramic, a polymer, a metal alloy, and so on) that is compatible with the substance contained therein.
  • the vessel 14d containing water is shown with conduit 15 and a valve, not shown, connected to an external source (such as, filtered/treated tap water) 21 to allow for uninterrupted resupply of vessel 14d throughout operations.
  • an external source such as, filtered/treated tap water
  • Operation of the vessel is represented at 17a as a processor in electrical communication with some type of storage device 25 (any peripheral unit or device, whether housed internally or externally hardwired or wireless, that holds data such as magnetic tape, magnetic disk optical disk, diskettes, flash cards, magnetic drums, and so on), a user interface 16 (such as a touch-sensitive screen or display 16a, keyboard/keypad 16b, light pen 16c, joysticks and trackballs 16d, mouse 16e, printer /OCR-scanner 16f, audio signal receiver/microphone 16g along with voice-recognition circuitry to digitize spoken words and enters them into the computer, and so on) for receiving input concerning the mixture selected, batch number, whether titration/reaction steps are to be performed, etc., and some type of wide area network (WAN) 24 that can be employed if input data is to be received or transmitted remotely such as through the global information network known as the INTERNET network.
  • WAN wide area network
  • the user input can be any type suitable for the environment in which the apparatus will operate.
  • the apparatus may have to operate within a high humidity chamber or it may be used by gloved technicians with caustic materials on the outside of the gloves. In that case, it is preferably to chose a hermetically-sealed interface that is easy to activate (touch screen or voice-activated, for example).
  • the user interface may also be one that is remote to the apparatus, such as outside the humidity chamber or offsite in a material storage warehouse. In this case, the user interface may be interconnected to computerized control system 17a via WAN 24.
  • At 17b is a box representing the automated dispensing and dosing functions) of the apparatus.
  • the apparatus and method of the invention are preferably carried out by incorporating a processing unit linked by a communication network, or bus, to both a user interface 16 (which can be something as simple a coded activation 'keys' pre-programmed for a preselected mixture preparation 'recipe') and internal memory that can call-up instructions stored on a storage device comprising the detailed sequence of instructions to direct the apparatus to perform the preparation steps.
  • a processing unit linked by a communication network, or bus
  • CPU central processing unit
  • microprocessors have four functional sections: (1) the arithmetic/logic unit, (2) temporary storage locations, called registers, which hold data, instructions, or the results of calculations; (3) the control section; and (4) the internal bus, a network of communication lines that links internal CPU elements and offers several different data paths for input from and output to other elements of the computer system
  • Computer refers to any general-purpose apparatus that processes data according to a set of instructions stored internally either temporarily or permanently. Data is stored both memory and on more-permanent storage units/devices. The semi-permanent or permanent holding place for data is generally called “storage" and memory is the more-temporary workspace for executing instructions and processing data.
  • a set of instructions that perform a particular task is generally referred to as a program or software program.
  • FIG. 2 diagrammatically illustrates additional design features that further distinguish the apparatus 50 and method 300 of the invention from known processes and systems.
  • a housing or shroud 41 built of suitable structurally-sound material, covers several components of the apparatus as will be explained further.
  • Each vessel here, labeled 34a - 34
  • a support structure not labeled for simplicity
  • FIGs. 3-5A and 5B with shroud 41 removed
  • the receptacle such as the flask 40 positioned on receptacle support 43.
  • user interface panel 36 In communication with the processor employed to carry out the instructions/commands for preparation of a mixture is user interface panel 36 having buttons/keys 37, an LED alphanumeric display 39, and LED indication lights 38 to communicate preparation status.
  • any suitable user- input interface may be employed, including one remotely located.
  • Base 45 is on rollers 47a-47c and has a handle 35 for portability.
  • Receptacle support 43 is stationed on base 45 and shelving 46 has been added.
  • spokes 49a-49 of framework 48A may be rotatively coupled to axis member 48B which is, in turn, affixed to base 55.
  • End-projections (59a, 59c in FIG. 4) of spokes 49a-49 extend through support openings 54a, 54b of the upper ends of bag-type flexible-walled vessels 34a - 34f) as well as dedicated measurement assemblies 64a - 64f can readily be seen.
  • Extending below each assembly 64a - 64f is a piston rod (respectively 68a - 68f) and extending from each assembly 64a - 64f is a flow channel (respectively 66a - 66 )- all of which will be further explained.
  • a dose actuator mechanism 80 Stationed in positional relationship with receptacle support 53 on base 55 is a dose actuator mechanism 80.
  • each vessel 34a - 34 ⁇ has a port (such as those labeled 72a, 72c) and a first flow channel (such as those labeled 74a, 74c) leading to a respective valve (preferably directional/check valves) labeled 76a-76f and in communication with a respective measurement assembly 64a - 64f and second flow channels 66a-66g which each include a hinged connector 78a-78 for design flexibility.
  • receptacle support 53 has been located under assembly 64c for collecting fluent substance flowing from flow channel 66c into receptacle 40.
  • Dose actuator mechanism 80 has extensions 84A, 84B to station it to base 55 via sustaining (axis) member 48B.
  • dose actuator 80 operates as follows (please see also FIG. 5A): A push- surface 85 is activated to push against a bottom end of a respective piston rod (such as that at 68a, 68c, 68 ) in an upwardly direction to push a head (such as those labeled 67a, 67c in FIG. 5A) correspondingly upward to force the fluent substance dispensed into a respective piston cylinder volume (as labeled 64a, 64c in FIG. 5A), having passed through upstream valves 76a-76f.
  • the novel dosing actuator 80 illustrated provides excellent dosing accuracy.
  • Dose actuator 80 can have a motor
  • the actuator will be automatically controlled to size cylinder volume 64a, 64c as needed according to requisite dosage of fluent substance from a respective vessel.
  • Projections 59c may be hook-shaped to anchor respective vessels 34a - 34 ⁇
  • Corresponding structure in alternative apparatus 100 of FIG. 5B includes: circuitously arranged vessels 134a-134 ⁇ on framework (including spoke 149 ⁇ ) coupled to axis member 148B, measurement assemblies 164a-164 ⁇ circuitously arranged on the framework (supporting spokes for the assemblies 164a-164 ⁇ are not in view, here, but can be seen in FIG. 3 and labeled 78A), and receptacle 40 on receptacle support 93 is shown in operative relation with second flow channel hinge 178 ⁇ and vessel 134 ⁇ .
  • the flexible- alled vessel 130 of FIG. 6 has an upper-end 137 through which an opening 138 passes.
  • a lower-end 139 has an exit port 136 and a flow channel 144B having tubular outer wall 144D, is in further communication with connector 144C and a pinch-type valve 144A.
  • An additional port 132A (such as for filling the vessel) has been permanently closed at 132B.
  • the apparatus 250 of FIGs. 7A-7C views have structure corresponding to that in FIGs. 2, 3, 4, 5A-5B as can be readily appreciated, including a titration probe 213 (for automatic titration, represented at box 320 in FIG. 8, of the mixture to balance its pH, or to perform some other special operation/reaction to meet a desired substance parameter) and mixer assembly 290 (having a suitable agitator device, such as a stir-rod or magnetic stir-dowel, may be lowered to mix collected substances together).
  • a suitable agitator device such as a stir-rod or magnetic stir-dowel
  • Fluent substances includes the multitude of substances considered flowable, or capable of flowing already identified such as reagents, cleaning solutions, water (with many uses, including use as an inorganic solvent), organics, pesticides, and other substances used in a production/test type environment.
  • reagents as defined, is any chemical compound used in laboratory analyses to detect and identify specific constituents of the material being examined.
  • reagents may be gases, liquids, or solids, they are usually prepared as solutions (in water or common solvents) of various concentrations, e.g., 1 molar, 0.1 normal, etc.
  • reagents include, without limitation: glacial acetic acid; sulfuric acid; hydrogen sulfide; dimethylglyoxime; potassium iodide; 0.05 M Potassium Phosphate, pH 7.5; Sodium Acetate Buffer Solution, pH 5.0; .5 % SLS in 0.1 M Phosphate Buffer (pH 8.0); 0.05 M Potassium Phosphate, pH 6.8; .025 M Phosphate pH 3.2, has Phosphoric and Acetic Acid; .05 M Sodium Phosphate pH 6.8; 0.2% diethylamine in 0.2 M Potassium Phosphate.
  • 'solvent' is a term that designates a liquid which can reduce certain solids or liquids to molecular or ionic form by relaxing the intermolecular forces that unite them. There are tens-of-thousands of solvents currently in use.

Abstract

An apparatus and method of preparing a mixture using a computerized apparatus having a plurality of vessels (34a-34f), each of which is arranged on a support structure and oriented for dispensing a fluent substance through at least one exit port and a first flow channel (74a, 74c). Each first flow channel is in further communication with a dedicated measurement assembly (64a-64f), for dosing fluent substance so dispensed, and a second flow channel (66a-66g). The apparatus also includes a receptacle support (43); and can further incorporate a user interface (16) for receiving a first input concerning the mixture plus a storage device to hold instructions for locating a respective one of the second flow channels and the receptacle support in operative relation. The apparatus can further comprise titration and mixing modules or a support structure having a framework coupled to a sustaining member for accommodating flexible-walled vessels.

Description

Apparatus for Automatic Preparation of a Mixture and Method
Background of the Invention
In general, the present invention relates to the preparation of mixtures including liquid reagents, cleaning and other special-purpose solutions, solvents, pesticides, herbicides, paints, mixed beverages, fluent foodstuff, as well as other fluent substances used in the laboratory, manufacturing plant floor, field crops, gardens, eating establishments, building structures, art lab, and so on. Common to the preparation of such a wide range of types of mixtures are the tasks of selecting, dosing, and mixing the necessary constituent fluent components into a receptacle. More particularly, the invention relates to the automation of such mixture preparation using a novel apparatus, whether the constituent components are uniformly distributed within the mixture. This apparatus and associated method utilizes a unique automated technique to , in accordance with input concerning a desired end-product, select at least one of a plurality of available fluent constituent components staged on a support structure, dose/measure a requisite amount of each selected constituent component, collect the dosed amount with mixing receptacle, and agitate/stir the collected contents in the receptacle to prepare the preselected end-product. A processor and storage device are readily adapted to collect and store data concerning the preparation, as desired.
The footprint of the apparatus can be chosen for portability. And although a variety of vessels containing constituent components can be made of rigid or brittle materials, a support structure of the apparatus is adaptable for the arrangement of gravity fed, 'bag-like' flexible walled vessels.
There are many reagents/buffers, special-purpose solutions, solvents, paints, pesticides, herbicides, the list goes on, for commercial and personal use, used in research laboratories in small quantities. Very often, lab and QA (quality assurance) technicians, line employees, etc. , need only a single batch that includes one or more 'flasks-full', for example, of a mixture tailored for a particular study /analysis/test or other use. Every time a new reagent, solvent, solution, or other mixture is needed, the laborious process of preparing begins, over again: The appropriate formula is pulled from laboratory files (or, if none, one must be calculated), bottles of the necessary ingredients are located and removed from storage, and ingredients are measured using equipment which has to, first, be cleaned and decontaminated from any prior use. Further, the process of mixing beverages such as is done at a wedding party, alumni gathering, or other function likewise requires small 'flasks' of different beverages requiring preparation in various batch-quantities. This is also true of the production process to prepare foodstuff in small amounts . Traditionally, mixtures that are used in smaller quantities in production lines, commercial laboratories as well as private and government research laboratories, are prepared manually on an as-needed basis. First, a trained lab technician carefully measures out the requisite amount of each raw material-ingredient from the glass container(s) in which it was shipped to the lab and is currently being stored. Many reagents, solutions, and solvents are prepared using ingredients that are quite caustic and toxic. The quantities of ingredients measured for use, are mixed in an appropriately-sized beaker or flask. The highly labor intensive process of preparing solutions used in commercial manufacturing and research laboratories not only creates opportunity for human error and serious injury, but is also very costly.
Therefore, a versatile automatic, less labor-intensive and less error-prone process is needed. Preferably such a process is carried out using a computerized apparatus designed to be generally portable, with a footprint that can accommodate the limited available counter top space found in most laboratories, manufacturing environments, and eating establishments. The innovative apparatus and method described herein utilize a unique sophisticated technique to automatically: (a) access, dispense, and dose appropriate quantities of selected ingredients held in containment vessels in proximity to one another, this being done according to input entered through some type of user interface as well as a plurality of instructions/commands stored for automatic retrieval into computer memory, and (b) collect each such ingredient into a receptacle (such as a flask, beaker, etc.) for mixing and auto-titration (as desired). Although this new apparatus incorporates sophisticated automation techniques, its features allow for ready access to finished mixture-product. The unique automatic access to fluent ingredients, as well as dispensing and dosing techniques, can be employed by an apparatus with a footprint considered large (floor- model) or small (counter-top) to prepare a wide variety of mixtures.
Unlike the labor-intensive processes currently available, the new apparatus and associated method require much less intervention by a lab technician, line worker, etc. and provides sufficient production quality control over batch sizes of hundreds of flasks of prepared mixtures. As can be appreciated, within the spirit and scope of the design goals contemplated hereby, and as further described herein, many different types of suitable alternative structures for carrying out specified function(s) may be incorporated into the new apparatus and method of the invention. Further, the incorporation of flexible-walled vessels ('bag-type') having novel features invented by certain of the listed applicant-inventors hereof, and assigned to the assignee hereof, helps address problems associated with cumbersome transport and storage of heavy, breakable ceramic (e.g. , glass) hard- walled containers. These unique flexible-walled vessels can be fabricated from many suitable materials into many different shapes and sizes, and filled with countless different types of fluent substance ingredients as needed for preparing desired mixtures. Summary of the Invention
It is a primary object of this mvention to provide an apparatus and associated method of preparmg a mixture using a computerized apparatus having a plurality of vessels, each of which is arranged on a support structure and oriented for dispensing a fluent substance through at least one exit port and a first flow channel. The first flow channel of each vessel is in further communication with a dedicated measurement assembly, for dosmg fluent substance so dispensed, and a second flow channel. The apparatus also includes a receptacle support; and can further incorporate a user interface for receiving a first input concerning the mixture plus a storage device to hold instructions for locatmg a respective one of the second flow channels and the receptacle support in operative relation (for collecting the fluent substance in a mixture receptacle placed on the receptacle support). The apparatus can further comprise titration and mixing modules; and an alternative apparatus and method can utilize a support structure havmg a framework moveably coupled to a sustaining member, whereby many flexible-walled vessels can be accommodated.
Several advantages of providmg the novel apparatus and associated method, follow:
(a) Versatility- The invention can be used for automatic preparation of smgle-flask batches of different mixtures, or repeated preparation of a large quantity (multiple flasks of one mixture).
(b) Structural design flexibility- An apparatus of the invention can stage a multitude of constituent fluent ingredients (including solvents, buffers/reagents, homogeneous and non- homogeneous solutions, titrants, including reactants, etc.) for access and dispensing dependmg on the mstructions/commands and mput received for the preparation of the preselected mixture. The apparatus can be driven by its own power source (especially important for the field), or connected to an external source of power such as line voltage from an electrical wall oudet.
(c) Simplicity of use - Different batch-quantities of any one such mixture can readily be prepared with a touch of a keypad button or touch-sensitive screen, a voice command or joystick/mouse, etc. The new apparatus can be sized for portability and mstalled and relocated with ease and without disruption of surrounding environment. A user has at her fingertips, a panoply of programmmg mstructions/commands for preparmg hundreds of thousands of different mixtures as well as the flexibility to create new ones; and maintenance/calibration can automated. (d) Design flexibility— The apparatus can be sized to accommodate any number of ingredient vessels arranged and one or more of the vessels can be fed externally if usage of its contents is great throughout a day, for example. Also, many suitable mechanisms exist (and are handily adapted or redesigned) to carry out the following: receive user input, measure/dose fluent substances dispensed from a vessel, agitate/mix the substances, and titrate substances collected (e) Process speed and reliability /repeatability— Reducing the need for trained technicians to carry out each of the meticulous steps required to prepare the mιxture(s), allows the process of preparing to occur at a faster rate, while being less prone to error (repeatability increases) This makes it possible to more-economically prepare a variety of preselected mixtures (regardless of batch quantities and/or product mix/variety requirements throughout a given day).
(f) Compact/efficient design- To optimize production, several apparatuses (built with a smaller footprint) can be positioned at different locations within a production or lab environment and operated simultaneously, or sequentially, to create different, or the same, mixtures. The use of flexible-walled bag type vessels, makes possible, on-the-fly replacement thereof.
(g) End-product preparation tracking- The automated features of the apparatus and method make tracking of batches, for quality assurance or other purposes such as replemshmg stock of fluent substances consumed, straight-forward to integrate and implement into existmg production, eating establishment, and lab environments (especially where highly regulated/monitored).
Briefly described, once again, the invention includes an apparatus for automatic preparation of a preselected mixture, comprising: a plurality of vessels, each vessel arranged on a support structure and oriented for dispensing a fluent substance through at least one exit port and a first flow channel. Each of the first flow channels is in further communication with a dedicated measurement assembly and a second flow channel. The apparatus also has a receptacle support, a user interface for receiving a first input concerning the mixture, and a storage device holding a plurality of instructions for locating a respective one of the second flow channels and the receptacle support in operative relation for collecting the fluent substance. The mixtures which can be prepared utilizing the invention include liquid reagents , cleaning and other special-purpose solutions, solvents, pesticides, herbicides, paints, mixed beverages, fluent foodstuff, as well as other fluent substances used in the laboratory, manufacturing plant floor, field crops, gardens, eating establishments, building structures, art lab, and so on.
There are additional features that further distinguish this invention from known devices and methods: (a) the support structure comprises a framework moveably coupled to a sustaining member; (b) a dose actuator stationed in positional relationship with the receptacle support; (c) the vessels having been hermetically formed of flexible stock material into a 'bag-type' shape; (d) mixing and titration modules; and (e) further instructions on the storage device can include: instructions for dispensing from the first flow channel the requisite amount of fluent substance from a respective vessel; instructions for directing a respective one of the dedicated measurement devices to dose the fluent substance so dispensed; instructions for rotating, or otherwise moving/sliding/positiomng/placing, a respective one of the vessels and/or an associated dedicated measurement assembly and/or the receptacle support, to position a respective second flow channel above the receptacle support; instructions for automatically mixmg and/or titrating, including any type of analysis/reaction performed on or to, substances collected in a mixture receptacle; and instructions for repeating the process according to input about batch size/quantities. The invention also includes a method of preparing a preselected mixture using a computerized apparatus, including the steps of (a) receiving a first input concerning the mixture; and (b) according to the first input and a plurality of instructions held on a storage device of the apparatus: automatically locating a second flow channel and a receptacle support in operative relation; dispensing a fluent substance through at least one exit port and a first flow channel from a respective one of a plurality of vessels arranged on a suppoπ structure of the apparatus, each of the first flow channels in further communication with a dedicated measurement assembly and a second flow channel; and using the measurement assembly, dosing the fluent substance so dispensed. The additional features listed above, further distinguish the method of the invention.
Brief Description of the Drawings
For purposes of illustrating the flexibility of design and versatility of the innovative preferred apparatus and method, the invention will be more particularly described by referencing the accompanying drawings of embodiments of the invention (in which like numerals designate like parts). The figures have been included to communicate the features of the invention by way of example, only, and are in no way intended to unduly limit the disclosure hereof.
FIG. 1 diagrammatically illustrates features of a preferred apparatus 10 of the invention. FIG. 2 is an isometric of a preferred apparatus 30 detailing further structural features. FIG. 3 is an isometric of an alternative apparatus labeled 50, with shroud 41 removed and certain other features slightly altered.
FIG. 4 is a side view of the alternative apparatus 50 in FIG. 3.
FIG. 5A is a schematic side view representation of the apparatus 50 illustrating many of the features shown in FIG. 4, in further detail. FIG. 5B is a schematic top view of an alternative apparatus 100 to show representative locations of certain of the features.
FIG. 6 is an isometric illustrating a preferred flexible- walled vessel 130 of the invention in use alongside laboratory-type equipment supported by an alternative framework.
FIGs. 7A, 7B, and 7C are schematic representation (two side views and a top view, respectively) of an alternative apparatus 250, again detailing certain features of the invention.
FIG. 8 is a flow diagram detailing preferred steps, in an expanded novel manner, of a method 300 of preparing a preselected mixture using a unique apparatus of the invention.
Detailed Description of the Preferred Embodiments As identified above, the apparatus of the invention 10 is shown with several appropriately sized vessels labeled 14a - 14f in fluent communication 18a- 18f with a spout or collection channel 19 and into a receptacle 20. At some point prior to operating the apparatus, each vessel is filled with the fluent substance ingredient and arranged for dispensing along a respective channel 18a- 18f according to amount of use throughout the period of operation. Vessels can be made of made of any sturdy flexible-walled or other material (e.g. , a glass or other ceramic, a polymer, a metal alloy, and so on) that is compatible with the substance contained therein. Certain of the substances may be used so often during mixture preparation operations that it is beneficial to communicate with an external source. For example, the vessel 14d containing water is shown with conduit 15 and a valve, not shown, connected to an external source (such as, filtered/treated tap water) 21 to allow for uninterrupted resupply of vessel 14d throughout operations.
Operation of the vessel is represented at 17a as a processor in electrical communication with some type of storage device 25 (any peripheral unit or device, whether housed internally or externally hardwired or wireless, that holds data such as magnetic tape, magnetic disk optical disk, diskettes, flash cards, magnetic drums, and so on), a user interface 16 (such as a touch-sensitive screen or display 16a, keyboard/keypad 16b, light pen 16c, joysticks and trackballs 16d, mouse 16e, printer /OCR-scanner 16f, audio signal receiver/microphone 16g along with voice-recognition circuitry to digitize spoken words and enters them into the computer, and so on) for receiving input concerning the mixture selected, batch number, whether titration/reaction steps are to be performed, etc., and some type of wide area network (WAN) 24 that can be employed if input data is to be received or transmitted remotely such as through the global information network known as the INTERNET network. The user input can be any type suitable for the environment in which the apparatus will operate. For example, the apparatus may have to operate within a high humidity chamber or it may be used by gloved technicians with caustic materials on the outside of the gloves. In that case, it is preferably to chose a hermetically-sealed interface that is easy to activate (touch screen or voice-activated, for example). The user interface may also be one that is remote to the apparatus, such as outside the humidity chamber or offsite in a material storage warehouse. In this case, the user interface may be interconnected to computerized control system 17a via WAN 24. At 17b is a box representing the automated dispensing and dosing functions) of the apparatus.
The apparatus and method of the invention are preferably carried out by incorporating a processing unit linked by a communication network, or bus, to both a user interface 16 (which can be something as simple a coded activation 'keys' pre-programmed for a preselected mixture preparation 'recipe') and internal memory that can call-up instructions stored on a storage device comprising the detailed sequence of instructions to direct the apparatus to perform the preparation steps. By way of background, central processing unit (CPU) chips and microprocessors have four functional sections: (1) the arithmetic/logic unit, (2) temporary storage locations, called registers, which hold data, instructions, or the results of calculations; (3) the control section; and (4) the internal bus, a network of communication lines that links internal CPU elements and offers several different data paths for input from and output to other elements of the computer system Computer, and computerized, refers to any general-purpose apparatus that processes data according to a set of instructions stored internally either temporarily or permanently. Data is stored both memory and on more-permanent storage units/devices. The semi-permanent or permanent holding place for data is generally called "storage" and memory is the more-temporary workspace for executing instructions and processing data. A set of instructions that perform a particular task is generally referred to as a program or software program.
FIG. 2 diagrammatically illustrates additional design features that further distinguish the apparatus 50 and method 300 of the invention from known processes and systems. Here, a housing or shroud 41, built of suitable structurally-sound material, covers several components of the apparatus as will be explained further. Each vessel (here, labeled 34a - 34 ) has been oriented on a centrally-located sustaining member 48 of a support structure (not labeled for simplicity) for the purpose of unobstructed dispensing its contents into internal measuring equipment (as can be seen in FIGs. 3-5A and 5B with shroud 41 removed) for dosing and further final flow into the receptacle (such as the flask 40 positioned on receptacle support 43). In communication with the processor employed to carry out the instructions/commands for preparation of a mixture is user interface panel 36 having buttons/keys 37, an LED alphanumeric display 39, and LED indication lights 38 to communicate preparation status. As mentioned, any suitable user- input interface may be employed, including one remotely located. Base 45 is on rollers 47a-47c and has a handle 35 for portability. Receptacle support 43 is stationed on base 45 and shelving 46 has been added.
In FIG. 3, one can see how spokes 49a-49 of framework 48A may be rotatively coupled to axis member 48B which is, in turn, affixed to base 55. End-projections (59a, 59c in FIG. 4) of spokes 49a-49 extend through support openings 54a, 54b of the upper ends of bag-type flexible-walled vessels 34a - 34f) as well as dedicated measurement assemblies 64a - 64f can readily be seen. Extending below each assembly 64a - 64f is a piston rod (respectively 68a - 68f) and extending from each assembly 64a - 64f is a flow channel (respectively 66a - 66 )- all of which will be further explained. Stationed in positional relationship with receptacle support 53 on base 55 is a dose actuator mechanism 80.
As can better be appreciated in FIG. 4, each vessel 34a - 34ø has a port (such as those labeled 72a, 72c) and a first flow channel (such as those labeled 74a, 74c) leading to a respective valve (preferably directional/check valves) labeled 76a-76f and in communication with a respective measurement assembly 64a - 64f and second flow channels 66a-66g which each include a hinged connector 78a-78 for design flexibility. One can see how receptacle support 53 has been located under assembly 64c for collecting fluent substance flowing from flow channel 66c into receptacle 40. Dose actuator mechanism 80 has extensions 84A, 84B to station it to base 55 via sustaining (axis) member 48B. In operation as designed (but certainly not limited to this particular structure) dose actuator 80 operates as follows (please see also FIG. 5A): A push- surface 85 is activated to push against a bottom end of a respective piston rod (such as that at 68a, 68c, 68 ) in an upwardly direction to push a head (such as those labeled 67a, 67c in FIG. 5A) correspondingly upward to force the fluent substance dispensed into a respective piston cylinder volume (as labeled 64a, 64c in FIG. 5A), having passed through upstream valves 76a-76f. The novel dosing actuator 80 illustrated provides excellent dosing accuracy.
Certain features can be better appreciated in FIG. 5A. Dose actuator 80 can have a motor
81 or other mechanism coupled to threaded dowel 82 to translate electrical power into mechanical drive power to activate push-surface 85. The actuator will be automatically controlled to size cylinder volume 64a, 64c as needed according to requisite dosage of fluent substance from a respective vessel. Projections 59c may be hook-shaped to anchor respective vessels 34a - 34ø
Corresponding structure in alternative apparatus 100 of FIG. 5B includes: circuitously arranged vessels 134a-134ø on framework (including spoke 149ø) coupled to axis member 148B, measurement assemblies 164a-164ø circuitously arranged on the framework (supporting spokes for the assemblies 164a-164ø are not in view, here, but can be seen in FIG. 3 and labeled 78A), and receptacle 40 on receptacle support 93 is shown in operative relation with second flow channel hinge 178ø and vessel 134ø.
The flexible- alled vessel 130 of FIG. 6 has an upper-end 137 through which an opening 138 passes. A lower-end 139 has an exit port 136 and a flow channel 144B having tubular outer wall 144D, is in further communication with connector 144C and a pinch-type valve 144A. An additional port 132A (such as for filling the vessel) has been permanently closed at 132B.
The apparatus 250 of FIGs. 7A-7C views, have structure corresponding to that in FIGs. 2, 3, 4, 5A-5B as can be readily appreciated, including a titration probe 213 (for automatic titration, represented at box 320 in FIG. 8, of the mixture to balance its pH, or to perform some other special operation/reaction to meet a desired substance parameter) and mixer assembly 290 (having a suitable agitator device, such as a stir-rod or magnetic stir-dowel, may be lowered to mix collected substances together). Likewise, one can better appreciate the novel features of the method 300 of the invention as illustrated by way of a flow diagram in FIG. 8. Without further additional commentary provided here, one can readily appreciate the features of the invention from specific written detail added to FIG. 8 for convenient viewing, of the steps illustrated. Fluent substances, as that term is used herein, includes the multitude of substances considered flowable, or capable of flowing already identified such as reagents, cleaning solutions, water (with many uses, including use as an inorganic solvent), organics, pesticides, and other substances used in a production/test type environment. 'Reagent', as defined, is any chemical compound used in laboratory analyses to detect and identify specific constituents of the material being examined. Though reagents may be gases, liquids, or solids, they are usually prepared as solutions (in water or common solvents) of various concentrations, e.g., 1 molar, 0.1 normal, etc. Several thousand chemicals of varying specificity are used as reagents; they are subject to strict specifications, especially as regards purity. A non-exhaustive list of reagents includes, without limitation: glacial acetic acid; sulfuric acid; hydrogen sulfide; dimethylglyoxime; potassium iodide; 0.05 M Potassium Phosphate, pH 7.5; Sodium Acetate Buffer Solution, pH 5.0; .5 % SLS in 0.1 M Phosphate Buffer (pH 8.0); 0.05 M Potassium Phosphate, pH 6.8; .025 M Phosphate pH 3.2, has Phosphoric and Acetic Acid; .05 M Sodium Phosphate pH 6.8; 0.2% diethylamine in 0.2 M Potassium Phosphate. Generally, 'solvent' is a term that designates a liquid which can reduce certain solids or liquids to molecular or ionic form by relaxing the intermolecular forces that unite them. There are tens-of-thousands of solvents currently in use.
While certain representative embodiments and details have been shown merely for the purpose of illustrating the invention, those skilled in the art will readily appreciate that various modifications may be made to the invention without departing from the novel teachings or scope of this invention. Accordingly, all such modifications are intended to be included within the scope of this invention as defined in the following claims. Although the commonly employed preamble phrase "comprising the steps of" may be used herein, or hereafter, in a method claim, the Applicants in no way intend to invoke limitations of 35 USC section 112 ^6. Furthermore, in any claim that is filed herein or hereafter, any means-plus-function clauses used, or later found to be present, are intended to cover the structures described herein as performing the recited function and not only structural equivalents but also equivalent structures.

Claims

What is claimed is:
1. An apparatus for automatic preparation of a preselected mixture, comprising: a plurality of vessels, each vessel arranged on a support structure and oriented for dispensing a fluent substance through at least one exit port and a first flow channel, each said first flow channel in further communication with a dedicated measurement assembly and a second flow channel; a receptacle support; a user interface for receiving a first input concerning the mixture; and a storage device holding a plurality of instructions for locating a respective one of said second flow channels and said receptacle support in operative relation for collecting said fluent substance.
2. The apparams of Claim 1 wherein the mixture is selected from the group consisting of liquid reagents, cleaning solutions, solvents, pesticides, herbicides, paints, mixed beverages, and fluent foodstuff; said instructions for locating further comprises instructions for rotating a respective one of said plurality of vessels to position said respective second flow channel above said receptacle support; and said plurality of instructions further comprises instructions for directing a respective one of said dedicated measurement assemblies to dose, according to said input, said fluent substance so dispensed.
3. The apparams of Claim 1 wherein: said support structure comprises a framework rotatively coupled to an axis member, said vessels are circuitously arranged on said framework; and the apparatus further comprises a dose actuator stationed in positional relationship with said receptacle support.
4. The apparams of Claim 3 further comprising a dedicated check valve upstream of each of said measurement assembly and wherein: an upper-end and a lower-end of each said vessel has been hermetically formed from a flexible tubular stock material; said framework comprises a plurality of projections, each said projection to fit through a support opening of said upper-end to hold a respective one of said plurality of vessels; and each said measurement assembly further comprises a piston chamber within which a head connected to a first end of a rod is disposed.
5. The apparatus of Claim 4 wherein said dose actuator comprises a push-surface in connection with a movable linkage, whereby upward movement of said push-surface against a second end of a respective one of said rods causes said head to force any said fluent substance within said piston chamber out and through said respective second flow channel.
6. The apparams of Claim 3 wherein: said measurement assemblies are circuitously arranged on said framework in proximity to said vessels; each said measurement assembly being movable vertically along said axis member, and further comprising a piston chamber within which a head connected to a first end of a rod is disposed; said respective second flow channel to comprise a tubular-extension; and said operative relation for collecting to comprise said tubular- extension located over said receptacle support.
7. The apparatus of Claim 1 wherein: said support structure comprises a framework movably coupled to a sustaining member, said vessels are arranged on said framework; and the apparams further comprises a titration module and a mixer, each stationed in positional relationship with said receptacle support.
8. The apparatus of Claim 7 wherein the mixture is selected from the group consisting of liquid reagents, cleaning solutions, solvents, pesticides, herbicides, paints, mixed beverages, and fluent foodstuff; said instructions for locating further comprises instructions for positioning said receptacle support under said respective second flow channel; and said plurality of instructions further comprises instructions for directing a respective one of said dedicated measurement assemblies to dose, according to said input, said fluent substance so dispensed.
9. The apparams of Claim 1 wherein: said support structure comprises a framework rotatively coupled to a sustaining member, said vessels and measurement assemblies are circuitously arranged on said framework; and the apparatus further comprises a mixer stationed in positional relationship with said receptacle support.
10. The apparams of Claim 9 further comprising a mixture receptacle on said receptacle support; and wherein said first input comprises information about a preselected number of batches and a chemical make-up of the mixture; said sustaining member is an axis member, each said measurement assembly vertically movable therealong; and said user interface comprises a display.
11. The apparatus of Claim 9 further comprising a titration module stationed in positional relationship with said receptacle support; each of said vessels is flexible-walled with an associated said first flow channel hermetically extending from a respective exit port; and wherein said framework comprises a plurality of outwardly extending spokes upon which said flexible- walled vessels hang.
12. The apparatus of Claim 9 further comprising a portable base to which said sustaining member is affixed, and a shroud covering said measurement assemblies and a does actuator stationed in positional relationship with said receptacle support upon said base.
13. A method of preparing a preselected mixture using a computerized apparams, comprising the steps of: receiving a first input concerning the mixture; and according to said first input and a plurality of instructions held on a storage device of the apparams: automatically locating a second flow channel and a receptacle support in operative relation; dispensing a fluent substance through at least one exit port and a first flow channel from a respective one of a plurality of vessels arranged on a support structure of the apparams, each said first flow channel in further communication with a dedicated measurement assembly and a second flow channel; and using said measurement assembly, dosing said fluent substance so dispensed.
14. The method of Claim 13 further comprising the step of positioning a mixture receptacle on said receptacle support; and wherein said step of automatically locating said second flow channel further comprises rotating said respective vessel and a respective one of said dedicated measurement assemblies such that said second flow channel is over said mixture receptacle.
15. The method of Claim 14 further comprising the steps of: preselecting said mixture from the group consisting of liquid reagents, cleaning solutions, solvents, pesticides, herbicides, paints, mixed beverages, and fluent foodstuff, and manually entering said first input, comprising said preselection, through a user interface of the apparams; collecting said dosed fluent substance in said mixture receptacle; mixing said collected fluent substance; and further according to said first input, automatically titrating said collected fluent substance to balance pH thereof.
16. The method of Claim 13 wherein: said step of automatically locating said second flow channel further comprises moving said receptacle support under said second flow channel; and said step of dosing further comprises the steps of allowing said dispensed fluent substance to pass through a check valve in communication with said first flow channel and into a volume of a piston chamber of a respective one of said dedicated measurement assemblies, and actuating a dose actuator stationed in positional relationship with said receptacle support.
17. The method of Claim 16 wherein: said step of automatically locating said second flow channel further comprises also moving, vertically along a sustaining member of said support structure, said respective dedicated measurement assembly; and said step of actuating further comprises moving, in an upwardly direction, a push- surface of said dose actuator against a second end of a rod connected to a head disposed within said piston chamber.
18. The method of Claim 13 further comprising the steps of: positioning a mixture receptacle on said receptacle support; collecting said dosed fluent substance in said mkture receptacle; and further according to said first input, automatically moving a framework of said support structure so that said second flow channel associated with said respective vessel is no longer in said operative relation with said receptacle support, and locating a second flow channel in communication with a second one of said plurality of vessels over said receptacle support.
19. The method of Claim 18 further comprising the steps of: dispensing a second fluent substance through at least one second vessel port and a first flow channel from said second vessel; using a second one of said dedicated measurement assemblies in communication with said first flow channel from said second vessel, dosing said second fluent substance so dispensed; and collecting said dosed second fluent substance in said mixture receptacle.
20. The method of Claim 19 further comprising the steps of: m ing said collected fluent substances within said mixture receptacle; and further according to said first input, automatically titrating said collected fluent substances to balance pH thereof, comprising inserting a pH probe into said collected fluent substances and adding pH solution as directed.
21. An apparams for automatic preparation of a preselected mixture, comprising: a plurality of vessels, each vessel arranged on a support structure and oriented for dispensing a fluent substance through a first flow channel that is in further communication with a dedicated measurement assembly for dosing said substance so dispensed; a user interface for receiving a first input concerning the mixture; and a storage device holding a plurality of instructions for said dosing, according to said input.
PCT/US2000/012229 1999-05-08 2000-05-06 Apparatus for automatic preparation of a mixture and method WO2000068137A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10/030,659 US6793387B1 (en) 1999-05-08 2000-05-06 Apparatus for automatic preparation of a mixture and method
AU51263/00A AU5126300A (en) 1999-05-08 2000-05-06 Apparatus for automatic preparation of a mixture and method

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13325199P 1999-05-08 1999-05-08
US60/133,251 1999-05-08

Publications (1)

Publication Number Publication Date
WO2000068137A1 true WO2000068137A1 (en) 2000-11-16

Family

ID=22457706

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/012229 WO2000068137A1 (en) 1999-05-08 2000-05-06 Apparatus for automatic preparation of a mixture and method

Country Status (2)

Country Link
AU (1) AU5126300A (en)
WO (1) WO2000068137A1 (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1428569A2 (en) * 2002-12-10 2004-06-16 Valpaint S.r.l. Apparatus for dosing colored pigments and for mixing the pigments with a predetermined quantity of paint or enamel to be coloured
EP1541225A1 (en) * 2003-12-11 2005-06-15 Schulz GmbH Metering device for emulsions paints
WO2005044041A3 (en) * 2003-10-30 2005-12-01 Fluid Management Inc Automated cosmetics dispenser for point of sale cosmetics products
EP1636092A1 (en) * 2003-06-06 2006-03-22 E-Z-EM, Inc. Peristaltic syringe filling station
EP1647519A1 (en) * 2004-10-14 2006-04-19 MARCHESINI GROUP S.p.A. Machine for filling containers with liquid products
US7206664B2 (en) 2001-03-09 2007-04-17 Mettler-Toledo Ag Device and method for mixing substances
ES2316217A1 (en) * 2006-02-10 2009-04-01 Jose Javier Prieto Martin Mixer of paints for modeling, picture and miniaturism. (Machine-translation by Google Translate, not legally binding)
US7703483B2 (en) 2004-06-04 2010-04-27 Acist Medical Systems, Inc. Peristaltic syringe filling station
JP2016026183A (en) * 2008-03-28 2016-02-12 アナ・ルチア・シュミット・ロレンソ・ロドリゲス Method of producing personal care product containing fluid mixture
CN112109929A (en) * 2020-09-29 2020-12-22 黄沙沙 Automatic mixed porridge and coarse cereal bagging machine

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3122272A (en) * 1960-08-04 1964-02-25 Marsh Lyle Fluid dispenser
US4258759A (en) * 1979-03-29 1981-03-31 Achen John J Turntable for colorant dispensers
US4403866A (en) * 1982-05-07 1983-09-13 E. I. Du Pont De Nemours And Company Process for making paints
US4676286A (en) * 1983-01-28 1987-06-30 Azionaria Costruzioni Macchine Automatiche, A.C.M.A. S.P.A. Volumetric filling machine
US4946100A (en) * 1988-02-16 1990-08-07 Flemming J Peter Liquid dispenser
US5078302A (en) * 1989-07-17 1992-01-07 Fluid Management Limited Partnership Paint dispensing apparatus
US5119973A (en) * 1990-12-14 1992-06-09 Fluid Management Limited Partnership Automated dispensing apparatus
US5474211A (en) * 1993-03-23 1995-12-12 Hellenberg; Leendert Method of dispensing materials with improved accuracy

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3122272A (en) * 1960-08-04 1964-02-25 Marsh Lyle Fluid dispenser
US4258759A (en) * 1979-03-29 1981-03-31 Achen John J Turntable for colorant dispensers
US4403866A (en) * 1982-05-07 1983-09-13 E. I. Du Pont De Nemours And Company Process for making paints
US4676286A (en) * 1983-01-28 1987-06-30 Azionaria Costruzioni Macchine Automatiche, A.C.M.A. S.P.A. Volumetric filling machine
US4946100A (en) * 1988-02-16 1990-08-07 Flemming J Peter Liquid dispenser
US5078302A (en) * 1989-07-17 1992-01-07 Fluid Management Limited Partnership Paint dispensing apparatus
US5119973A (en) * 1990-12-14 1992-06-09 Fluid Management Limited Partnership Automated dispensing apparatus
US5474211A (en) * 1993-03-23 1995-12-12 Hellenberg; Leendert Method of dispensing materials with improved accuracy

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1377803B2 (en) 2001-03-09 2009-04-01 Mettler-Toledo AG Device and method for the mixing of substances, in particular of dyes
US7206664B2 (en) 2001-03-09 2007-04-17 Mettler-Toledo Ag Device and method for mixing substances
EP1428569A3 (en) * 2002-12-10 2004-08-25 Valpaint S.r.l. Apparatus for dosing colored pigments and for mixing the pigments with a predetermined quantity of paint or enamel to be coloured
EP1428569A2 (en) * 2002-12-10 2004-06-16 Valpaint S.r.l. Apparatus for dosing colored pigments and for mixing the pigments with a predetermined quantity of paint or enamel to be coloured
EP1636092A1 (en) * 2003-06-06 2006-03-22 E-Z-EM, Inc. Peristaltic syringe filling station
EP1636092A4 (en) * 2003-06-06 2010-01-20 Acist Medical Sys Inc Peristaltic syringe filling station
WO2005044041A3 (en) * 2003-10-30 2005-12-01 Fluid Management Inc Automated cosmetics dispenser for point of sale cosmetics products
DE10357861A1 (en) * 2003-12-11 2005-07-14 Schulz Gmbh Farben- Und Lackfabrik Dosing plant for emulsion paints
DE10357861B4 (en) * 2003-12-11 2005-11-24 Schulz Gmbh Farben- Und Lackfabrik Dosing plant for emulsion paints
WO2005061085A1 (en) * 2003-12-11 2005-07-07 Schulz Gmbh Farben- Und Lackfabrik Dosing arrangement for dispersion paints
EP1541225A1 (en) * 2003-12-11 2005-06-15 Schulz GmbH Metering device for emulsions paints
US7942569B2 (en) 2003-12-11 2011-05-17 Schulz Gmbh Farben-Und Lackfabrik Metering system for preparing emulsion paints from multiple aqueous paint components
US7703483B2 (en) 2004-06-04 2010-04-27 Acist Medical Systems, Inc. Peristaltic syringe filling station
EP1647519A1 (en) * 2004-10-14 2006-04-19 MARCHESINI GROUP S.p.A. Machine for filling containers with liquid products
ES2316217A1 (en) * 2006-02-10 2009-04-01 Jose Javier Prieto Martin Mixer of paints for modeling, picture and miniaturism. (Machine-translation by Google Translate, not legally binding)
JP2016026183A (en) * 2008-03-28 2016-02-12 アナ・ルチア・シュミット・ロレンソ・ロドリゲス Method of producing personal care product containing fluid mixture
CN112109929A (en) * 2020-09-29 2020-12-22 黄沙沙 Automatic mixed porridge and coarse cereal bagging machine

Also Published As

Publication number Publication date
AU5126300A (en) 2000-11-21

Similar Documents

Publication Publication Date Title
US6793387B1 (en) Apparatus for automatic preparation of a mixture and method
US8858066B2 (en) Liquid dispensing for high-throughput experimentation
Christensen et al. Automation isn't automatic
JP6290903B2 (en) Experimental equipment and method for automatic processing of experimental samples
US5366896A (en) Robotically operated laboratory system
US6694197B1 (en) Single channel reformatter
WO2000068137A1 (en) Apparatus for automatic preparation of a mixture and method
JP4528814B2 (en) Automatic analyzer and method of operating automatic analyzer
WO2003065030A1 (en) Fluid handling methods and systems
JP3024375B2 (en) Automatic pretreatment device
JPH09255593A (en) Information management system for automated multiple simultaneous synthesis
CN103175976A (en) Automatic analysis device and detection body separate injection method thereof
JP2005537127A (en) Method and apparatus for mixing liquid samples using sinusoidal mixing
US20030225477A1 (en) Modular equipment apparatus and method for handling labware
EP1232381A2 (en) Aerosol can content analyzer workstation
Felton Product review: Liquid handling: Dispensing reliability
Carvalho Miau, a microbalance autosampler
Hubschmann Automated sample preparation: Methods for GC-MS and LC-MS
Hardin et al. Automating combinatorial chemistry: A primer on benchtop robotic systems
JPS6244663A (en) Automatic analyzing instrument with many items
RU2488801C2 (en) Method of collecting and diluting portions of radioactive solution and apparatus for realising said method (versions)
Cork et al. Further development of a versatile microscale automated workstation for parallel adaptive experimentation
Dong The Use of the Laboratory Robot for Sample Preparation
JP2001249137A (en) Autoanalyzer
CN215471184U (en) Programmable chemical experiment robot

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 10030659

Country of ref document: US

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 69(1) EPC (EPO FORM 1205A SENT 25.03.03)

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 69(1) EPC

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP