WO2000073796A3 - Ligand-anker-konjugate zur generierung einer biosensor-schicht - Google Patents
Ligand-anker-konjugate zur generierung einer biosensor-schicht Download PDFInfo
- Publication number
- WO2000073796A3 WO2000073796A3 PCT/DE2000/001705 DE0001705W WO0073796A3 WO 2000073796 A3 WO2000073796 A3 WO 2000073796A3 DE 0001705 W DE0001705 W DE 0001705W WO 0073796 A3 WO0073796 A3 WO 0073796A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ligand
- producing
- anchor conjugates
- conjugates
- anchor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
Abstract
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE50013234T DE50013234D1 (de) | 1999-05-28 | 2000-05-26 | Ligand-anker-konjugate zur generierung einer biosensor-schicht |
EP00949060A EP1185869B1 (de) | 1999-05-28 | 2000-05-26 | Ligand-anker-konjugate zur generierung einer biosensor-schicht |
JP2001512319A JP2003505702A (ja) | 1999-05-28 | 2000-05-26 | 生物活性センサー |
AU62585/00A AU6258500A (en) | 1999-05-28 | 2000-05-26 | Bioactive sensors |
CA002375120A CA2375120A1 (en) | 1999-05-28 | 2000-05-26 | Bioactive sensors |
US09/995,491 US20020127577A1 (en) | 1999-05-28 | 2001-11-27 | Bioactive sensors |
US11/077,907 US20050153357A1 (en) | 1999-05-28 | 2005-03-10 | Bioactive sensors |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19924606.8 | 1999-05-28 | ||
DE19924606A DE19924606A1 (de) | 1999-05-28 | 1999-05-28 | Ligand-Anker-Konjugate |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000073796A2 WO2000073796A2 (de) | 2000-12-07 |
WO2000073796A3 true WO2000073796A3 (de) | 2001-07-05 |
Family
ID=7909553
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DE2000/001705 WO2000073796A2 (de) | 1999-05-28 | 2000-05-26 | Ligand-anker-konjugate zur generierung einer biosensor-schicht |
Country Status (8)
Country | Link |
---|---|
US (2) | US20020127577A1 (de) |
EP (1) | EP1185869B1 (de) |
JP (1) | JP2003505702A (de) |
AT (1) | ATE334393T1 (de) |
AU (1) | AU6258500A (de) |
CA (1) | CA2375120A1 (de) |
DE (2) | DE19924606A1 (de) |
WO (1) | WO2000073796A2 (de) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10027397A1 (de) * | 2000-06-02 | 2001-12-13 | Graffinity Pharm Design Gmbh | Oberfläche zur Immobilisierung von Liganden |
JP2004531700A (ja) * | 2001-02-05 | 2004-10-14 | グラフィニティー、ファーマスーティカルス アーゲー | 低親和性スクリーニング法 |
GB0123120D0 (en) * | 2001-09-26 | 2001-11-14 | Amersham Pharm Biotech Uk Ltd | Method of attachment |
DE10220593A1 (de) * | 2001-11-28 | 2003-06-12 | Graffinity Pharmaceuticals Ag | SPR-Sensorflächenträger |
EP1453959A2 (de) * | 2001-11-28 | 2004-09-08 | Graffinity Pharmaceuticals Aktiengesellschaft | Verfahren zur selektion und identifikation von peptid- oder proteinmolekülen mittels phage display |
JP4878777B2 (ja) * | 2005-05-31 | 2012-02-15 | 公益財団法人野口研究所 | 低非特異相互作用糖鎖プローブ |
JP4742340B2 (ja) * | 2005-06-14 | 2011-08-10 | 独立行政法人産業技術総合研究所 | 硫酸基含有糖化合物、それを用いるサーズウイルスまたはインフルエンザウイルスの検出 |
JP4742339B2 (ja) * | 2005-06-14 | 2011-08-10 | 独立行政法人産業技術総合研究所 | シアル酸含有3糖化合物、それを用いるサーズウイルスまたはサーズスパイク蛋白質の検出 |
WO2008070222A2 (en) * | 2006-08-21 | 2008-06-12 | Cytotrend Biotech Engineering Limited Usa Inc | A method of surface plasmon resonance (spr) technology to detect genomic disorders for prenatal diagnosis |
DE102006039881A1 (de) * | 2006-08-25 | 2008-03-20 | Siemens Ag | Aminofunktionelles Haftvermittlersystem für Edelmetalloberflächen |
US20080115890A1 (en) * | 2006-09-11 | 2008-05-22 | Zhang Sean X | Methods and systems for using molecular-film adhesives |
US20100086920A1 (en) * | 2006-09-18 | 2010-04-08 | Cmed Technologies Ltd. | Method to assess cancer susceptibility and differential diagnosis of metastases of unknown primary tumors |
WO2008036470A2 (en) * | 2006-09-19 | 2008-03-27 | Cmed Technologies Ltd. | A method for screening of infectious agents in blood |
WO2008070223A2 (en) * | 2006-09-21 | 2008-06-12 | Cmed Technologies Ltd. | A method to remove repetitive sequences from human dna |
WO2008036474A2 (en) * | 2006-09-21 | 2008-03-27 | Cmed Technologies Ltd. | A method to detect tumor markers and diagnosis of undifferenciated tumors |
US20100047789A1 (en) * | 2006-09-25 | 2010-02-25 | Cmed Technologies Ltd. | Method of surface plasmon resonance (spr) to detect genomic disorders for postnatal diagnosis |
US20090311699A1 (en) * | 2006-09-25 | 2009-12-17 | Cmed Technologies Ltd. | Method of surface plasmon resonance (spr) to detect genomic aberrations in patients with chronic lymphocytic leukemia |
US20100041018A1 (en) * | 2006-09-25 | 2010-02-18 | Cmed Technologies Ltd. | Method to detect virus related immunological markers for the diagnosis of hepatitis c virus infection |
US20100028856A1 (en) * | 2006-09-25 | 2010-02-04 | Cmed Technologies Ltd. | Method to detect virus related immunological markers for the diagnosis of hepatitis b virus infection |
WO2008070227A2 (en) * | 2006-09-25 | 2008-06-12 | Cmed Technologies Ltd. | A method for the identification of human immunodeficiency virus related antibodies in blood |
WO2008082710A2 (en) * | 2006-09-25 | 2008-07-10 | Cmed Technologies Ltd. | A method of surface plasmon resonance (spr) technology to detect genomic aberrations in patients with multiple myeloma |
US20100021930A1 (en) * | 2006-09-27 | 2010-01-28 | Cmed Technologies Ltd. | Application of surface plasmon resonance technology to maternal serum screening for congenital birth defects |
US8110409B2 (en) * | 2006-09-27 | 2012-02-07 | Cmed Technologies Ltd. | Method to measure serum biomarkers for the diagnosis of liver fibrosis |
US8114682B2 (en) * | 2006-09-27 | 2012-02-14 | Cmed Technologies Ltd. | Method for the quantitative evaluation of sex hormones in a serum sample |
WO2008066997A2 (en) * | 2006-09-27 | 2008-06-05 | Cmed Technologies Ltd. | A method for quantitative measurement of cardiac biochemical markers |
US20100086937A1 (en) * | 2006-09-27 | 2010-04-08 | Cmed Technologies Ltd. | method to detect treponema pallidum immunological markers for the diagnosis of syphilis |
US8158343B2 (en) * | 2006-09-27 | 2012-04-17 | Cmed Technologies Ltd. | Method to detect virus related immunological markers for the diagnosis of respiratory tract infections |
US8110408B2 (en) * | 2006-09-28 | 2012-02-07 | Cmed Technologies Ltd. | Method for quantitative detection of diabetes related immunological markers |
WO2008067007A2 (en) * | 2006-09-28 | 2008-06-05 | Cmed Technologies Ltd. | A method for quantitative measurement of thyroid homrones and related antibodies in a serum sample |
WO2009045216A1 (en) * | 2007-10-04 | 2009-04-09 | Cmed Technologies Ltd. | Application of surface plasmon resonance technology for detecting and genotyping hpv |
US7829735B2 (en) * | 2007-10-26 | 2010-11-09 | Northwestern University | Universal phosphoramidite for preparation of modified biomolecules and surfaces |
US9566236B2 (en) * | 2008-11-26 | 2017-02-14 | Nippon Telegraph And Telephone Corporation | Proteoliposome, production method thereof, and biochip |
GB201315335D0 (en) | 2013-08-29 | 2013-10-09 | Of Singapore | Amino diacids containing peptide modifiers |
US11500247B2 (en) | 2015-11-18 | 2022-11-15 | Platypus Technologies, Llc | Liquid crystal sensor |
WO2018156500A1 (en) * | 2017-02-21 | 2018-08-30 | The Board Of Regents For Oklahoma State University | Structure and synthesis of highly fluorinated amino acid derivatives |
CN109633149A (zh) * | 2018-12-20 | 2019-04-16 | 江苏美正生物科技有限公司 | 一种氨基残留物检测的通用中间体以及免疫层析检测方法 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992010757A1 (de) * | 1990-12-12 | 1992-06-25 | Boehringer Mannheim Gmbh | Universalbindefilm |
EP0574000A1 (de) * | 1992-06-11 | 1993-12-15 | Roche Diagnostics GmbH | Selbst assemblierende Monoschicht mit kurzkettigen Linkern |
US5514501A (en) * | 1994-06-07 | 1996-05-07 | The United States Of America As Represented By The Secretary Of Commerce | Process for UV-photopatterning of thiolate monolayers self-assembled on gold, silver and other substrates |
WO1998031839A2 (en) * | 1997-01-21 | 1998-07-23 | President And Fellows Of Harvard College | Electronic-property probing of biological molecules at surfaces |
EP0872735A1 (de) * | 1997-04-14 | 1998-10-21 | Roche Diagnostics GmbH | Verfahren zum Aufbringen von Reagenzspots |
US6127129A (en) * | 1999-05-04 | 2000-10-03 | Wisconsin Alumni Research Foundation | Process to create biomolecule and/or cellular arrays on metal surfaces and product produced thereby |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US23366A (en) * | 1859-03-29 | Metallic penholder | ||
US5763191A (en) * | 1990-12-12 | 1998-06-09 | Boehringer Mannheim Gmbh | Universal binding film |
ATE173767T1 (de) * | 1992-04-03 | 1998-12-15 | Perkin Elmer Corp | Proben zusammensetzung und verfahren |
US5554501A (en) * | 1992-10-29 | 1996-09-10 | Beckman Instruments, Inc. | Biopolymer synthesis using surface activated biaxially oriented polypropylene |
DE69434998T2 (de) * | 1993-05-27 | 2008-03-13 | Aventis Pharmaceuticals Inc. | Topologisch getrennte, kodierende Festphasen-Bibliotheken |
EP0871650B1 (de) * | 1995-12-07 | 2003-06-25 | Genzyme Limited | Organische festphasensynthese |
JP2002528562A (ja) * | 1998-08-28 | 2002-09-03 | グリフォン サイエンシーズ | 長さのばらつきが小さいポリアミド連鎖、その連鎖の製造方法およびその連鎖とタンパク質の複合体 |
DE10027397A1 (de) * | 2000-06-02 | 2001-12-13 | Graffinity Pharm Design Gmbh | Oberfläche zur Immobilisierung von Liganden |
-
1999
- 1999-05-28 DE DE19924606A patent/DE19924606A1/de not_active Ceased
-
2000
- 2000-05-26 AU AU62585/00A patent/AU6258500A/en not_active Abandoned
- 2000-05-26 AT AT00949060T patent/ATE334393T1/de not_active IP Right Cessation
- 2000-05-26 EP EP00949060A patent/EP1185869B1/de not_active Expired - Lifetime
- 2000-05-26 CA CA002375120A patent/CA2375120A1/en not_active Abandoned
- 2000-05-26 DE DE50013234T patent/DE50013234D1/de not_active Expired - Lifetime
- 2000-05-26 JP JP2001512319A patent/JP2003505702A/ja not_active Withdrawn
- 2000-05-26 WO PCT/DE2000/001705 patent/WO2000073796A2/de active IP Right Grant
-
2001
- 2001-11-27 US US09/995,491 patent/US20020127577A1/en not_active Abandoned
-
2005
- 2005-03-10 US US11/077,907 patent/US20050153357A1/en not_active Abandoned
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992010757A1 (de) * | 1990-12-12 | 1992-06-25 | Boehringer Mannheim Gmbh | Universalbindefilm |
EP0574000A1 (de) * | 1992-06-11 | 1993-12-15 | Roche Diagnostics GmbH | Selbst assemblierende Monoschicht mit kurzkettigen Linkern |
US5514501A (en) * | 1994-06-07 | 1996-05-07 | The United States Of America As Represented By The Secretary Of Commerce | Process for UV-photopatterning of thiolate monolayers self-assembled on gold, silver and other substrates |
WO1998031839A2 (en) * | 1997-01-21 | 1998-07-23 | President And Fellows Of Harvard College | Electronic-property probing of biological molecules at surfaces |
EP0872735A1 (de) * | 1997-04-14 | 1998-10-21 | Roche Diagnostics GmbH | Verfahren zum Aufbringen von Reagenzspots |
US6127129A (en) * | 1999-05-04 | 2000-10-03 | Wisconsin Alumni Research Foundation | Process to create biomolecule and/or cellular arrays on metal surfaces and product produced thereby |
Non-Patent Citations (3)
Title |
---|
BROCKMAN ET AL: "A Multistep Chemical Modification Procedure To Create DNA Arrays on Gold Surfaces for the Study of Protein-DNA Interactions with Surface Plasmon Resonance Imaging", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC,US, vol. 121, no. 35, 1999, pages 8044 - 8051, XP002148625, ISSN: 0002-7863 * |
HUISMAN B -H ET AL: "Self-Assembled Monolayers of Calix[4]arene derivatives on Gold", TETRAHEDRON LETTERS,NL,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 36, no. 18, 1 May 1995 (1995-05-01), pages 3273 - 3276, XP004028245, ISSN: 0040-4039 * |
J SPINKE, M LILEY, F-J SCHMITT, H-J GUDER, L ANGERMAIER, W KNOLL: "Molecular recognition at self-assembled monolayers: Optimization of surface functionalization", JOURNAL OF CHEMICAL PHYSICS, vol. 99, no. 9, 1 November 1993 (1993-11-01), pages 7012 - 7019, XP000972391 * |
Also Published As
Publication number | Publication date |
---|---|
JP2003505702A (ja) | 2003-02-12 |
EP1185869B1 (de) | 2006-07-26 |
DE50013234D1 (de) | 2006-09-07 |
US20050153357A1 (en) | 2005-07-14 |
ATE334393T1 (de) | 2006-08-15 |
EP1185869A2 (de) | 2002-03-13 |
WO2000073796A2 (de) | 2000-12-07 |
US20020127577A1 (en) | 2002-09-12 |
CA2375120A1 (en) | 2000-12-07 |
AU6258500A (en) | 2000-12-18 |
DE19924606A1 (de) | 2000-11-30 |
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