WO2000075237A3 - pH SENSITIVE CYANINE DYES AS REACTIVE FLUORESCENT REAGENTS - Google Patents
pH SENSITIVE CYANINE DYES AS REACTIVE FLUORESCENT REAGENTS Download PDFInfo
- Publication number
- WO2000075237A3 WO2000075237A3 PCT/US2000/015682 US0015682W WO0075237A3 WO 2000075237 A3 WO2000075237 A3 WO 2000075237A3 US 0015682 W US0015682 W US 0015682W WO 0075237 A3 WO0075237 A3 WO 0075237A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- straight
- branched alkyl
- cyanine dyes
- cooh
- integer
- Prior art date
Links
- 0 CC1(C)c(cc(cc2)S(O)(=O)=O)c2N=C1C=CC=C(*c1c2)N(*)c1cc(*)c2I Chemical compound CC1(C)c(cc(cc2)S(O)(=O)=O)c2N=C1C=CC=C(*c1c2)N(*)c1cc(*)c2I 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001502512A JP2003501540A (en) | 1999-06-09 | 2000-06-08 | PH-functional cyanine dyes as reactive fluorescent reagents |
EP00942696A EP1212375A2 (en) | 1999-06-09 | 2000-06-08 | Ph sensitive cyanine dyes as reactive fluorescent reagents |
CA002375740A CA2375740A1 (en) | 1999-06-09 | 2000-06-08 | Ph sensitive cyanine dyes as reactive fluorescent reagents |
AU57284/00A AU5728400A (en) | 1999-06-09 | 2000-06-08 | Ph sensitive cyanine dyes as reactive fluorescent reagents |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13829799P | 1999-06-09 | 1999-06-09 | |
US60/138,297 | 1999-06-09 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2000075237A2 WO2000075237A2 (en) | 2000-12-14 |
WO2000075237A3 true WO2000075237A3 (en) | 2002-04-11 |
WO2000075237A9 WO2000075237A9 (en) | 2002-05-10 |
Family
ID=22481396
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/015682 WO2000075237A2 (en) | 1999-06-09 | 2000-06-08 | pH SENSITIVE CYANINE DYES AS REACTIVE FLUORESCENT REAGENTS |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1212375A2 (en) |
JP (1) | JP2003501540A (en) |
AU (1) | AU5728400A (en) |
CA (1) | CA2375740A1 (en) |
WO (1) | WO2000075237A2 (en) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6080868A (en) | 1998-01-23 | 2000-06-27 | The Perkin-Elmer Corporation | Nitro-substituted non-fluorescent asymmetric cyanine dye compounds |
WO2002026891A1 (en) | 2000-09-29 | 2002-04-04 | Molecular Probes, Inc. | Modified carbocyanine dyes and their conjugates |
JP2003048879A (en) * | 2001-05-31 | 2003-02-21 | Nisshinbo Ind Inc | Fluorescent group-containing carbodiimide compound and method for manufacturing the compound |
EP2258776A1 (en) * | 2002-05-10 | 2010-12-08 | Carnegie Mellon University | Fluorescent cyanine dyes containing functional groups |
ITPZ20030002A1 (en) | 2003-08-12 | 2005-02-13 | Giuseppe Caputo | COMPOUNDS OF THE CIANINA TYPE WITH AN ALCHINYLIC ARM |
CN100349869C (en) * | 2004-12-10 | 2007-11-21 | 华东理工大学 | Cyanine dye containing end alkynyl radical and its synthesis process |
EP1954763B1 (en) | 2005-11-28 | 2016-11-16 | Dako Denmark A/S | Cyanine dyes and methods for detecting a target using said dyes |
US7279296B2 (en) | 2005-12-16 | 2007-10-09 | General Electric Company | Compositions and methods for lipoprotein uptake assays |
WO2008099914A1 (en) * | 2007-02-16 | 2008-08-21 | The University Of Tokyo | Fluorescent probe |
US8465985B2 (en) | 2007-03-01 | 2013-06-18 | The University Of Tokyo | Fluorescent probe |
WO2009107769A1 (en) * | 2008-02-29 | 2009-09-03 | 国立大学法人東京大学 | Reagent for measurement of reactive oxygen |
FR2934684B1 (en) | 2008-07-31 | 2012-11-16 | Cis Bio Int | METHOD OF DETECTING INTERNALIZATION OF MEMBRANE PROTEINS. |
JP2010184866A (en) * | 2009-02-10 | 2010-08-26 | Nagoya Univ | Inspection reagent for fluorescent observation of intestinal mucosa |
US8051947B2 (en) | 2009-03-12 | 2011-11-08 | E.I. Du Pont De Nemours And Company | Energy absorbing thermoplastic elastomer |
US10053447B2 (en) | 2010-12-21 | 2018-08-21 | Pierce Biotechnology, Inc | Fluorescent compounds |
US8889884B1 (en) | 2011-07-14 | 2014-11-18 | Pierce Biotechnology, Inc. | Phosphine derivatives of fluorescent compounds |
US9249307B2 (en) | 2011-08-16 | 2016-02-02 | Pierce Biotechnology, Inc. | Benzocyanine compounds |
US9751868B2 (en) | 2012-02-28 | 2017-09-05 | Pierce Biotechnology, Inc. | Benzocyanine compounds |
WO2013130761A1 (en) | 2012-03-02 | 2013-09-06 | Pierce Biotechnology, Inc. | Indole derivatives as labeling dye for biomolecule |
DK2831587T3 (en) | 2012-03-27 | 2018-07-23 | Ventana Med Syst Inc | Signaling conjugates and methods of use |
EP2850078B1 (en) | 2012-08-28 | 2018-04-25 | Pierce Biotechnology, Inc. | Benzopyrylium compounds |
US20150160246A1 (en) | 2013-12-11 | 2015-06-11 | Analiza, Inc. | Devices and methods for determining and/or isolating cells such as circulating cancer or fetal cells |
US9709556B2 (en) | 2013-12-11 | 2017-07-18 | Analiza, Inc. | Devices and methods for determining and/or isolating circulating cancer cells |
CN103804370A (en) * | 2014-02-08 | 2014-05-21 | 南京博炫生物科技有限公司 | Fluorescent dye compound and preparation method and application thereof |
WO2017022559A1 (en) * | 2015-08-05 | 2017-02-09 | コニカミノルタ株式会社 | Environment-responsive dye-accumulated nano particles, and method for analyzing intracellular environment |
JP7423888B2 (en) * | 2019-11-22 | 2024-01-30 | 株式会社同仁化学研究所 | Dye for staining lipid bilayer membranes and method for staining lipid bilayer membranes using the same |
CN116601238A (en) | 2020-12-17 | 2023-08-15 | 伯拉考成像股份公司 | PH-responsive cyanine dyes and conjugates thereof |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4435492A (en) * | 1978-10-27 | 1984-03-06 | Hitachi, Ltd. | Complex type electrophotographic plate and electrophotographic method using the same |
US4524128A (en) * | 1983-10-24 | 1985-06-18 | Eastman Kodak Company | Spectrally sensitized silver halide photothermographic material |
US5268486A (en) * | 1986-04-18 | 1993-12-07 | Carnegie-Mellon Unversity | Method for labeling and detecting materials employing arylsulfonate cyanine dyes |
DE4341618A1 (en) * | 1993-12-07 | 1995-06-08 | Univ Schiller Jena | Near IR dyes useful as pH indicator for detecting toxins e.g. ammonia |
EP0747700A2 (en) * | 1995-06-07 | 1996-12-11 | Carnegie-Mellon University | Fluorescent labelling complexes with large stokes shifts formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer |
US6048982A (en) * | 1986-04-18 | 2000-04-11 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
-
2000
- 2000-06-08 WO PCT/US2000/015682 patent/WO2000075237A2/en not_active Application Discontinuation
- 2000-06-08 EP EP00942696A patent/EP1212375A2/en not_active Ceased
- 2000-06-08 AU AU57284/00A patent/AU5728400A/en not_active Abandoned
- 2000-06-08 JP JP2001502512A patent/JP2003501540A/en not_active Withdrawn
- 2000-06-08 CA CA002375740A patent/CA2375740A1/en not_active Abandoned
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4435492A (en) * | 1978-10-27 | 1984-03-06 | Hitachi, Ltd. | Complex type electrophotographic plate and electrophotographic method using the same |
US4524128A (en) * | 1983-10-24 | 1985-06-18 | Eastman Kodak Company | Spectrally sensitized silver halide photothermographic material |
US5268486A (en) * | 1986-04-18 | 1993-12-07 | Carnegie-Mellon Unversity | Method for labeling and detecting materials employing arylsulfonate cyanine dyes |
US6048982A (en) * | 1986-04-18 | 2000-04-11 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
DE4341618A1 (en) * | 1993-12-07 | 1995-06-08 | Univ Schiller Jena | Near IR dyes useful as pH indicator for detecting toxins e.g. ammonia |
EP0747700A2 (en) * | 1995-06-07 | 1996-12-11 | Carnegie-Mellon University | Fluorescent labelling complexes with large stokes shifts formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer |
Non-Patent Citations (2)
Title |
---|
MUJUMDAR R B ET AL: "CYANINE DYE LABELING REAGENTS CONTAINING ISOTHIOCYANATE GROUPS", CYTOMETRY,US,ALAN LISS, NEW YORK, vol. 10, no. 1, 1989, pages 11 - 19, XP000034880, ISSN: 0196-4763 * |
MUJUMDAR R B ET AL: "CYANINE DYE LABELING REAGENTS: SULFOINDOCYANINE SUCCINIMIDYL ESTERS", BIOCONJUGATE CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY, WASHINGTON, vol. 4, no. 2, 1 March 1993 (1993-03-01), pages 105 - 111, XP000654181, ISSN: 1043-1802 * |
Also Published As
Publication number | Publication date |
---|---|
AU5728400A (en) | 2000-12-28 |
JP2003501540A (en) | 2003-01-14 |
WO2000075237A2 (en) | 2000-12-14 |
WO2000075237A9 (en) | 2002-05-10 |
CA2375740A1 (en) | 2000-12-14 |
EP1212375A2 (en) | 2002-06-12 |
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