WO2001003598A1 - Naso-gastric reflectance spectroscopy probe - Google Patents
Naso-gastric reflectance spectroscopy probe Download PDFInfo
- Publication number
- WO2001003598A1 WO2001003598A1 PCT/US2000/018552 US0018552W WO0103598A1 WO 2001003598 A1 WO2001003598 A1 WO 2001003598A1 US 0018552 W US0018552 W US 0018552W WO 0103598 A1 WO0103598 A1 WO 0103598A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tube
- probe
- send
- fibers
- receive
- Prior art date
Links
- 0 CC1CC(CCC*)C(*CCN)*CC1 Chemical compound CC1CC(CCC*)C(*CCN)*CC1 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
- A61B5/4222—Evaluating particular parts, e.g. particular organs
- A61B5/4238—Evaluating particular parts, e.g. particular organs stomach
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
Definitions
- the present invention is a spectroscopy probe
- the present invention is a reflectance spectroscopy probe which can be used to monitor tissue in a patient's esophagus and stomach
- the instrument shown in the Anderson et al patent includes an optical probe which is releasably connected to an electronics package
- the probe is positioned on the tissue to be measured or analyzed
- the probe is interfaced to the instrument electromcs through optical fibers and a probe connector
- Light emitting diodes (LEDs) or other light sources in the instrument generate light at a number of different wavelengths
- the light used to measure the characteristics of the tissue is coupled to the probe by one or more send optical fibers After being transmitted from the tissue-engaging surface of the probe into the tissue being measured, the light will travel through the tissue before being collected at the end of the receive optical fiber This collected light is then transmitted to the instrument through the probe connector and electronics package connector
- the instrument also produces and transmits directly to the electronics package a reference light signal corresponding to each of the measurement light
- spectrophotomet ⁇ c instruments include LEDs, broadband or other light sources mounted within the electronics package or monitor Probes used in connection with monitors of this type have optical connectors on the ends of the fibers opposite the tissue-engaging surface The optical connectors mate with associated connectors on the monitor to couple the light between the monitor and probe tip In other instruments of this type, the LEDs or other light sources are mounted withm the optical connector portion of the probe
- the collected measurement light signals and reference light signals received by the electronics package are transmitted to a detector which produces electrical signals representative of these light signals at each wavelength of interest
- a processor/controller then processes these signals to generate data representative of the measured tissue parameter
- the measurement can be visually displayed on a display
- Algorithms used to compute the tissue parameter data are generally known and described m the Anderson et al patent
- the present invention is an improved probe for use with a spectrophotomet ⁇ c instrument
- One embodiment of the probe includes an elongated flexible tube for insertion into a tubular body structure
- the tube has a distal end and one or more send and receive optical fibers which extend through the tube
- the send and receive fibers have ends which terminate on the side of the tube near the distal end
- the tube is a naso-gast ⁇ c tube adapted to be inserted into a patient's stomach and esophagus, and includes suction apertures on the distal end
- a vacuum can be drawn through the tube to cause the send and receive optical fibers to be positioned in measurement contact with the tissue BRIEF DESCRIPTION OF THE DRAWINGS
- Figure 1 is an illustration of a naso-gast ⁇ c reflectance spectroscopy probe in accordance with the present invention
- Figure 2 is a detailed cross sectional view of a portion of the tip of the probe shown in Figure 1
- Figures 3-6 are detailed views of the fiber tip shown in Figure 2
- a naso-gast ⁇ c reflectance spectroscopy probe 20 in accordance with the present invention which can be used to analyze tissues in the stomach and esophagus of a patient is illustrated generally in Figures 1 and 2
- the probe 20 includes a flexible tube 22 having a tip 24 on its distal end 26
- the tip 24 includes a plurality of suction apertures 28 which extend through the tip 24 into a suction lumen 30 within the tip 24 and tube 22
- the suction lumen 30 is connected to a vacuum source connector 34
- a fiber tip 36 is mounted in one of the suction apertures 28 Alternatively, the fiber tip 36 can be mounted in a hole added to the probe 20 and adapted specifically for receiving the fiber tip 36
- One or more send optical fibers 38 and receive optical fibers 40 extend through the tube 22 and tip 24 of the probe 20 At the proximal end 32 of the tube 22 the send and receive fibers 38 and 40 extend from the tube 22 and can be coupled by connectors (not shown) to the monitor of a spectroscopy system (also not shown) At the distal end 26 of the tube 22, the ends of the send and receive fibers 38 and 40 are mounted in the fiber tip 36 with their end faces 42 and 44, respectively, generally flush with the outer surface 46 of the probe tip 24 Alternatively, side-firing optical fibers or mirrors (not shown) can be incorporated into the probe 20 to couple light between the end faces 42 and 44 of fibers 38 and 40, respectively, and the tissue being analyzed
- Commercially available naso-gast ⁇ c tubes can be used for the tube 22 and tip 24 of the probe 20 A 14 French naso-gast ⁇ c tube from Davol (model no 0042140) was used for one embodiment of the invention The send and
- the naso-gast ⁇ c probe 20 is inserted into the patient's stomach through his or her nose
- the vacuum source connector is coupled to a vacuum source in a conventional manner, while the send and receive fibers 38 and 40 are connected to the instrument monitor
- the probe tip 24, including the exposed end faces 42 and 44 of the send and receive fibers 38 and 40 will be drawn into engagement with the interior stomach wall
- Light from the send fiber 38 can then be effectively coupled into the stomach wall tissue
- light that has been transmitted through the tissue can be effectively collected by the receive fiber 40
- Insertion of the fibers 38 and 40 and fiber tip 36 into the tube 22 has minimal impact on the tube 22 itself and is considerably more efficacious than a larger tube having a blunt tip on its end
- the naso-gast ⁇ c probe 20 can be manufactured by bonding (e g , with epoxy) the send and receive fibers 38 and 40 to the fiber tip 36
- the end faces 42 and 44 of the send and receive fibers 38 and 40, respectively, can then be cleaved and polished on the side of the fiber tip 36
- the fiber tip 36 is then installed and bonded (e g , with epoxy) in the tip 24 of the naso-gast ⁇ c tube 22
- the fibers 38 and 40 are threaded through the lumen 48 of the tube 22 After connectors are mounted to the proximal ends 32 of the send and receive optical fibers 38 and 40, the fiber end faces 42 and 44 are polished
- the naso-gast ⁇ c reflectance spectroscopy probe 20 can be used to effectively illuminate and capture subsequent stomach tissue spectra Insertion of naso-gast ⁇ c tubes 22 through the nose and into the stomach of a patient is a medically accepted procedure
- a clinician can monitor characteristics such as oxygen saturation levels in stomach tissue at the same time as the functions of the naso-gast ⁇ c tube 22 are being provided Due to their small diameter, the optical fibers 38 and 40 are readily incorporated into a lumen 48 of the tube 22 with minimal impact to its overall flexibility and primary functionality
- the ability to add fibers into a conventional naso-gast ⁇ c tube reduces the need for a second mechanism for deploying the send and receive fibers into the stomach
- the need to "bottom out” the tube tip 24 in the stomach cavity to force the end faces 42 and 44 of the fibers 38 and 40 into contact with the tissue is reduced Instead, the probe tip 24 need only reside along an mside surface of the stomach wall When the vacuum is initiated, the stomach wall will be drawn toward the tube 22, thereby providing the target site for tissue illumination and spectra capture
- the optical fibers 38 and 40 can be made from plastic for maximum flexibility (e g , 400 ⁇ m in diameter) and coated with an opaque material to minimize cross-talk between send and receive channels
- the invention can be effectively implemented in forms which differ from that described above
- the send and receive fibers are not bonded to a common tip
- the end faces of the send and receive fibers can then be spaced from one another by greater distances without the presence of a stiff holder extending between the fibers
- the number of send and receive fibers need not be limited to one each
- the effective upper limit on the number of fibers is a function of the diameter of the tube lumen through which the fibers extend and the concurrent reduction in the available suction or irrigation capability
- Multiple send and receive locations are possible, thereby enabling the monitoring of tissue oxygenation or other characteristics at multiple sites using the same probe
- Similar or different depths of the tissue can be monitored at the multiple sites
- the fiber tip can be located at the very distal end of the tube Glass fibers can be substituted for the plastic fibers Different size diameter fibers can be used at the expense of decreasing flexibility of the tube or a reduction in the strength of the send and receive signals
- the fibers and fiber tip can be located at the very distal end of the
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00945211A EP1200001A1 (en) | 1999-07-08 | 2000-07-07 | Naso-gastric reflectance spectroscopy probe |
AU59187/00A AU5918700A (en) | 1999-07-08 | 2000-07-07 | Naso-gastric reflectance spectroscopy probe |
JP2001508887A JP2003504111A (en) | 1999-07-08 | 2000-07-07 | Nasogastric reflectance spectroscopy probe |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14282999P | 1999-07-08 | 1999-07-08 | |
US60/142,829 | 1999-07-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2001003598A1 true WO2001003598A1 (en) | 2001-01-18 |
Family
ID=22501460
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/018552 WO2001003598A1 (en) | 1999-07-08 | 2000-07-07 | Naso-gastric reflectance spectroscopy probe |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1200001A1 (en) |
JP (1) | JP2003504111A (en) |
AU (1) | AU5918700A (en) |
WO (1) | WO2001003598A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2495479A (en) * | 2011-10-03 | 2013-04-17 | Babiesfirst Ltd | Reflux probe |
US9591999B2 (en) | 2010-11-03 | 2017-03-14 | University Of Washington Through Its Center For Commercialization | Determination of tissue oxygenation in vivo |
USRE49062E1 (en) | 2012-04-12 | 2022-05-10 | Amorepacific Corporation | Foam having improved feeling during use |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3674013A (en) * | 1970-09-30 | 1972-07-04 | American Optical Corp | Fiberoptic catheter |
US4537197A (en) * | 1981-03-06 | 1985-08-27 | Hulka Jaroslav F | Disposable fetal oxygen monitor |
US4646722A (en) * | 1984-12-10 | 1987-03-03 | Opielab, Inc. | Protective endoscope sheath and method of installing same |
US4785815A (en) * | 1985-10-23 | 1988-11-22 | Cordis Corporation | Apparatus for locating and ablating cardiac conduction pathways |
US5190538A (en) * | 1991-04-22 | 1993-03-02 | Trimedyne, Inc. | Method and apparatus for subjecting a body site to a movable beam of laterally directed laser radiation |
US5324282A (en) * | 1989-10-25 | 1994-06-28 | Dodick Jack M | Surgical instrument with input power transducer |
DE4408746A1 (en) * | 1994-03-15 | 1995-09-21 | Medolas Ges Fuer Medizintechni | Laser catheter for bypass surgery |
EP0801928A1 (en) * | 1996-04-05 | 1997-10-22 | Eclipse Surgical Technologies, Inc. | Laser device with piercing tip for transmyocardial revascularization procedures |
-
2000
- 2000-07-07 WO PCT/US2000/018552 patent/WO2001003598A1/en not_active Application Discontinuation
- 2000-07-07 JP JP2001508887A patent/JP2003504111A/en active Pending
- 2000-07-07 AU AU59187/00A patent/AU5918700A/en not_active Abandoned
- 2000-07-07 EP EP00945211A patent/EP1200001A1/en not_active Withdrawn
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3674013A (en) * | 1970-09-30 | 1972-07-04 | American Optical Corp | Fiberoptic catheter |
US4537197A (en) * | 1981-03-06 | 1985-08-27 | Hulka Jaroslav F | Disposable fetal oxygen monitor |
US4646722A (en) * | 1984-12-10 | 1987-03-03 | Opielab, Inc. | Protective endoscope sheath and method of installing same |
US4785815A (en) * | 1985-10-23 | 1988-11-22 | Cordis Corporation | Apparatus for locating and ablating cardiac conduction pathways |
US5324282A (en) * | 1989-10-25 | 1994-06-28 | Dodick Jack M | Surgical instrument with input power transducer |
US5190538A (en) * | 1991-04-22 | 1993-03-02 | Trimedyne, Inc. | Method and apparatus for subjecting a body site to a movable beam of laterally directed laser radiation |
DE4408746A1 (en) * | 1994-03-15 | 1995-09-21 | Medolas Ges Fuer Medizintechni | Laser catheter for bypass surgery |
EP0801928A1 (en) * | 1996-04-05 | 1997-10-22 | Eclipse Surgical Technologies, Inc. | Laser device with piercing tip for transmyocardial revascularization procedures |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9591999B2 (en) | 2010-11-03 | 2017-03-14 | University Of Washington Through Its Center For Commercialization | Determination of tissue oxygenation in vivo |
US10463286B2 (en) | 2010-11-03 | 2019-11-05 | University Of Washington | Determination of tissue oxygenation in vivo |
GB2495479A (en) * | 2011-10-03 | 2013-04-17 | Babiesfirst Ltd | Reflux probe |
GB2495479B (en) * | 2011-10-03 | 2015-12-02 | Babiesfirst Ltd | Reflux probe |
USRE49062E1 (en) | 2012-04-12 | 2022-05-10 | Amorepacific Corporation | Foam having improved feeling during use |
Also Published As
Publication number | Publication date |
---|---|
AU5918700A (en) | 2001-01-30 |
JP2003504111A (en) | 2003-02-04 |
EP1200001A1 (en) | 2002-05-02 |
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