WO2001005352A1 - Apparatus and method for administration of medication - Google Patents

Apparatus and method for administration of medication Download PDF

Info

Publication number
WO2001005352A1
WO2001005352A1 PCT/GB2000/002758 GB0002758W WO0105352A1 WO 2001005352 A1 WO2001005352 A1 WO 2001005352A1 GB 0002758 W GB0002758 W GB 0002758W WO 0105352 A1 WO0105352 A1 WO 0105352A1
Authority
WO
WIPO (PCT)
Prior art keywords
vehicle
medication
container
administration
patient
Prior art date
Application number
PCT/GB2000/002758
Other languages
French (fr)
Inventor
Andrew John Ashworth
Lorna E. B. Ashworth
Original Assignee
Andrew John Ashworth
Ashworth Lorna E B
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9916773.6A external-priority patent/GB9916773D0/en
Application filed by Andrew John Ashworth, Ashworth Lorna E B filed Critical Andrew John Ashworth
Priority to AU60017/00A priority Critical patent/AU6001700A/en
Publication of WO2001005352A1 publication Critical patent/WO2001005352A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/009—Sachets, pouches characterised by the material or function of the envelope
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0015—Devices specially adapted for taking medicines
    • A61J7/0046—Cups, bottles or bags
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays

Definitions

  • This invention relates to an apparatus and method for administration of medication.
  • Opiate/opioid addicts may be treated by controlled administration of substitute medication.
  • Some such substitute medication is normally administered by mucosal route under supervision. However such medication has more potent effect if injected or "snorted". There is also a fostering black market for such medication. It is relatively simple for a patient to divert such medication for alternative use or resale, even when it is administered under supervision.
  • an apparatus for the mucosal administration of medication comprising a vehicle adapted for delivery of said medication.
  • Said vehicle may be retrievable after use.
  • said vehicle is adapted to be retrievable substantially intact after delivery.
  • said vehicle is adapted to enclose said medication.
  • said vehicle may be adapted to be impregnated with said medication.
  • Said vehicle may be adapted to fit in the mouth.
  • Said vehicle may be adapted to fit under the tongue.
  • said vehicle is comprised of material inert to saliva. More preferably said vehicle is comprised of material permeable to saliva.
  • said vehicle comprises a permeable container.
  • said container is adapted to receive medication during its manufacture.
  • Said container is preferably adapted to accommodate medication in solid form.
  • Said solid form may comprise a tablet.
  • Said solid form may comprise a frozen liquid.
  • said container is sealed.
  • said container is adapted to be sealed.
  • a method of administration of medication comprising the steps of: including said medication in a vehicle; supervising a patient while the vehicle is placed in a patient's mouth; waiting until the contents of the vehicle have been absorbed into the patient's bloodstream; reclaiming the vehicle; and ensuring the vehicle is intact.
  • said method comprises the step of sealing said medication within a permeable container. More preferably said method comprises the step of sealing said medication within a permeable container during manufacture of said container.
  • Fig 1 is a permeable container in accordance with an aspect of the invention.
  • Fig 2 is a permeable container in accordance with a further aspect of the invention.
  • an apparatus for the mucosal administration of medicament comprises a vehicle 1 in the form of a container 2, 3 substantially of permeable material.
  • the container 2, 3 is manufactured of material that is permeable to saliva, and that does not react with saliva.
  • the container 2 comprises a sealed pouch 4 of permeable material.
  • Medication 6 is placed within the pouch 4 during manufacture of this container 2, and the pouch 4 is then sealed. The medication is thus contained within the sealed pouch.
  • the container 3 comprises a pouch 8 with an opening 10, wherein the opening 10 is adapted to be sealed.
  • the opening 10 permits inclusion of a medicament.
  • the pouch 8 is substantially of material that contains a percentage of nylon. The edges of the opening 10 of the pouch can be fused by heat sealing once a medicament is placed therein.
  • Each vehicle 1 comprises a unique identifier to prevent its substitution.
  • This vehicle 1 is useful in administration of opiate/opiod medication to patients.
  • the medication is normally in tablet form and adapted to be delivered by mucosal route. That is, the medicament is designed to be absorbed under the tongue or elsewhere within the mouth. Tablets used for this purpose are small and easily hidden.
  • the administrator presents tablets to the patient in the sealed container 2,3 of the invention, which he then retrieves - still sealed - when empty. This allows the administrator to be satisfied that the contents of the container 2,3 have been absorbed into the bloodstream of the patient, and not diverted for other purposes.
  • the vehicle 1 of the instant invention also allows administrators of medication to reduce the possibility of diversion of medication with black market resale value if it becomes a requirement that a repeat prescription is only available on return of intact containers 2,3. This will reduce the likelihood of diversion of such medication for sale, for example by pensioners.
  • the structure of the vehicle 1 is impregnated with the medicament; or impregnated with or made from material that reacts with medication accommodated in the container 2,3 on dispensing.
  • the vehicle 1 also has application in administration of drugs to unconscious or disabled patients.
  • the size, shape or nature of the vehicle 1 is adapted to prevent inadvertent inhalation or swallowing of the vehicle 1.
  • the vehicle 1 has a portion adapted to protrude from the mouth when it is in position.
  • the protruding portion operates as a handle, allowing an administrator to retain control of the vehicle 1, and allowing easy removal of the spent vehicle 1 from a patient's mouth.
  • the protruding portion is a string or cord.
  • the vehicle 1 can be impregnated with, or otherwise contain a pH indicator. That is, the vehicle 1 can be customised for specific purposes.
  • the container 2, 3 will accommodate medication in tablet form, or in any solid form such as a frozen liquid.
  • the container 2,3 is soft and porous, and resembles a teabag.
  • the material from which teabags are manufactured is ideal for this vehicle 1.
  • medication 6 in tablet form is enclosed within this container 2,3.
  • the medication 6 is either sealed in the container 2 during its manufacture, or the container 3 is filled and sealed by or on behalf of the administrator.
  • Each vehicle 1 contains a unique identifier, such as a serial number.
  • the sealed container 2,3 is dispensed to the patient. The patient is observed while he places the container 2,3 in his mouth or under his tongue, for the period during which the medication is dissolving and being absorbed, and as he removes the empty container 2,3 from his mouth.
  • the administrator can then use the unique identifier to satisfy himself that there has been no replacement of containers 2,3 during this process. If this is the case, the administrator can then examine the container 2,3 to satisfy himself that the container 2,3 has not been tampered with, and remains intact.
  • the container 2,3 can also be made of material that is designed to dissolve, but at a rate slower than that of the medication it is adapted to contain.
  • the surface of the vehicle 1 can be impregnated with medication.
  • the vehicle 1 comprises a piece of material impregnated with a medicament .
  • This embodiment of the vehicle 1 does not require to be sealed, but is still retrievable intact by the administrator.
  • a further embodiment of the vehicle 1 comprises a container 2,3 the surface of which can be impregnated with material that changes the properties of the medication contained in the container 2,3 on dispensing.
  • the vehicle 1 can be used to administer medication to unconscious patients, and to monitor its absorption.
  • the vehicle 1 has application in administering medication to patients who require supervision to ensure that the medication is taken, such as geriatric and paediatric patients.
  • the vehicle 1 can be coloured, flavoured, patterned or otherwise decorated to make more palatable to children.
  • the vehicle 1 has further application for veterinary use.
  • the common features of all embodiments of the vehicle 1 are that they remain intact throughout the procedure of administration of medication, and are retrievable for scrutiny after administration to confirm that medication has been appropriately administered.

Abstract

Apparatus and method for the mucosal administration of medication .The apparatus has a vehicle adapted for delivery of said medication. The vehicle is retrievable after use to allow a supervisor to ensure that the medication has been correctly administered and to prevent misuse of any unadministered drug. Typically the vehicle is adapted to be retrievable substantially intact after delivery.

Description

Apparatus and Method for Administration of Medication
This invention relates to an apparatus and method for administration of medication.
Opiate/opioid addicts may be treated by controlled administration of substitute medication. Some such substitute medication is normally administered by mucosal route under supervision. However such medication has more potent effect if injected or "snorted". There is also a thriving black market for such medication. It is relatively simple for a patient to divert such medication for alternative use or resale, even when it is administered under supervision.
According to the present invention there is provided an apparatus for the mucosal administration of medication comprising a vehicle adapted for delivery of said medication.
Said vehicle may be retrievable after use. Typically said vehicle is adapted to be retrievable substantially intact after delivery. Preferably said vehicle is adapted to enclose said medication. Additionally or alternatively said vehicle may be adapted to be impregnated with said medication.
Said vehicle may be adapted to fit in the mouth. Said vehicle may be adapted to fit under the tongue.
Preferably said vehicle is comprised of material inert to saliva. More preferably said vehicle is comprised of material permeable to saliva.
Typically said vehicle comprises a permeable container.
Preferably said container is adapted to receive medication during its manufacture.
Said container is preferably adapted to accommodate medication in solid form. Said solid form may comprise a tablet. Said solid form may comprise a frozen liquid.
Preferably said container is sealed. Alternatively said container is adapted to be sealed.
Further according to the present invention there is provided a method of administration of medication comprising the steps of: including said medication in a vehicle; supervising a patient while the vehicle is placed in a patient's mouth; waiting until the contents of the vehicle have been absorbed into the patient's bloodstream; reclaiming the vehicle; and ensuring the vehicle is intact.
Preferably said method comprises the step of sealing said medication within a permeable container. More preferably said method comprises the step of sealing said medication within a permeable container during manufacture of said container.
Embodiments of the present invention will now be described by way of example only with reference to the accompanying drawings in which:
Fig 1 is a permeable container in accordance with an aspect of the invention; and
Fig 2 is a permeable container in accordance with a further aspect of the invention.
Referring to the drawings, an apparatus for the mucosal administration of medicament comprises a vehicle 1 in the form of a container 2, 3 substantially of permeable material. The container 2, 3 is manufactured of material that is permeable to saliva, and that does not react with saliva.
In the embodiment illustrated in Fig 1, the container 2 comprises a sealed pouch 4 of permeable material. Medication 6 is placed within the pouch 4 during manufacture of this container 2, and the pouch 4 is then sealed. The medication is thus contained within the sealed pouch.
In the embodiment illustrated in Fig 2, the container 3 comprises a pouch 8 with an opening 10, wherein the opening 10 is adapted to be sealed. The opening 10 permits inclusion of a medicament. In this embodiment the pouch 8 is substantially of material that contains a percentage of nylon. The edges of the opening 10 of the pouch can be fused by heat sealing once a medicament is placed therein.
Each vehicle 1 comprises a unique identifier to prevent its substitution.
This vehicle 1 is useful in administration of opiate/opiod medication to patients.
An example of appropriate patients would be recovering drug addicts. There is always the temptation for such patients to attempt to divert the medication for later more potent use or resale. For this reason, the medication is administered under supervision.
The medication is normally in tablet form and adapted to be delivered by mucosal route. That is, the medicament is designed to be absorbed under the tongue or elsewhere within the mouth. Tablets used for this purpose are small and easily hidden.
The administrator presents tablets to the patient in the sealed container 2,3 of the invention, which he then retrieves - still sealed - when empty. This allows the administrator to be satisfied that the contents of the container 2,3 have been absorbed into the bloodstream of the patient, and not diverted for other purposes.
That is, since the vehicle 1 is recoverable intact, there is a great degree of confidence that the medication has been properly administered to the intended patient.
The vehicle 1 of the instant invention also allows administrators of medication to reduce the possibility of diversion of medication with black market resale value if it becomes a requirement that a repeat prescription is only available on return of intact containers 2,3. This will reduce the likelihood of diversion of such medication for sale, for example by pensioners.
In a further embodiment the structure of the vehicle 1 is impregnated with the medicament; or impregnated with or made from material that reacts with medication accommodated in the container 2,3 on dispensing.
The vehicle 1 also has application in administration of drugs to unconscious or disabled patients. The size, shape or nature of the vehicle 1 is adapted to prevent inadvertent inhalation or swallowing of the vehicle 1.
For this purpose, the vehicle 1 has a portion adapted to protrude from the mouth when it is in position. The protruding portion operates as a handle, allowing an administrator to retain control of the vehicle 1, and allowing easy removal of the spent vehicle 1 from a patient's mouth. In one embodiment, the protruding portion is a string or cord.
Details concerning the contents of the vehicle 1, for example the dosage or patient ' s name or a serial number or date, can be printed and displayed or otherwise included on the surface of the material that comprises the vehicle 1.
The vehicle 1 can be impregnated with, or otherwise contain a pH indicator. That is, the vehicle 1 can be customised for specific purposes.
The container 2, 3 will accommodate medication in tablet form, or in any solid form such as a frozen liquid.
In the embodiments of Figure 1 and Figure 2, the container 2,3 is soft and porous, and resembles a teabag. The material from which teabags are manufactured is ideal for this vehicle 1. In use, medication 6 in tablet form is enclosed within this container 2,3. The medication 6 is either sealed in the container 2 during its manufacture, or the container 3 is filled and sealed by or on behalf of the administrator. Each vehicle 1 contains a unique identifier, such as a serial number. The sealed container 2,3 is dispensed to the patient. The patient is observed while he places the container 2,3 in his mouth or under his tongue, for the period during which the medication is dissolving and being absorbed, and as he removes the empty container 2,3 from his mouth.
The administrator can then use the unique identifier to satisfy himself that there has been no replacement of containers 2,3 during this process. If this is the case, the administrator can then examine the container 2,3 to satisfy himself that the container 2,3 has not been tampered with, and remains intact.
The container 2,3 can also be made of material that is designed to dissolve, but at a rate slower than that of the medication it is adapted to contain. The surface of the vehicle 1 can be impregnated with medication.
In one embodiment, the vehicle 1 comprises a piece of material impregnated with a medicament . This embodiment of the vehicle 1 does not require to be sealed, but is still retrievable intact by the administrator.
A further embodiment of the vehicle 1 comprises a container 2,3 the surface of which can be impregnated with material that changes the properties of the medication contained in the container 2,3 on dispensing.
The vehicle 1 can be used to administer medication to unconscious patients, and to monitor its absorption. The vehicle 1 has application in administering medication to patients who require supervision to ensure that the medication is taken, such as geriatric and paediatric patients. The vehicle 1 can be coloured, flavoured, patterned or otherwise decorated to make more palatable to children.
The vehicle 1 has further application for veterinary use.
The common features of all embodiments of the vehicle 1 are that they remain intact throughout the procedure of administration of medication, and are retrievable for scrutiny after administration to confirm that medication has been appropriately administered.
Improvements and modifications can be made to the above without departing from the scope of the invention.

Claims

1. Apparatus for mucosal administration of medication comprising a vehicle adapted for delivery of said medication.
2. Apparatus as claimed in claim 1, wherein said vehicle is retrievable after delivery.
3. Apparatus as claimed in either preceding claim, wherein said vehicle is adapted to be retrievable substantially intact after delivery.
4. Apparatus as claimed in any preceding claim, wherein said vehicle is adapted to enclose said medication.
5. Apparatus as claimed in any preceding claim, wherein said vehicle is adapted to be impregnated with said medication.
6. Apparatus as claimed in any preceding claim, wherein said vehicle is adapted to fit in the mouth.
7. Apparatus as claimed in any preceding claim, wherein said vehicle is adapted to fit under the tongue.
8. Apparatus as claimed in any preceding claim, wherein said vehicle is comprised of material inert to saliva.
9. Apparatus as claimed in any preceding claim, wherein said vehicle is comprised of material permeable to saliva.
10. Apparatus as claimed in any preceding claim, wherein said vehicle comprises a permeable container.
11. Apparatus as claimed in Claim 10, wherein said container is sealed.
12. Apparatus as claimed in Claim 10, wherein said container is adapted to be sealed.
13. Apparatus as claimed in any preceding claim, wherein said container is adapted to receive medication during its manufacture.
14. Apparatus as claimed in any preceding claim, wherein said container is adapted to accommodate medication in solid form.
15. Apparatus as claimed in Claim 14, wherein said solid form comprises a tablet or said solid form comprises a frozen liquid.
16. Method for administration of medication comprising the steps of: including said medication in a vehicle; supervising a patient while the vehicle is placed in a patient's mouth; waiting until the contents of the vehicle have been absorbed into the patient's bloodstream; reclaiming the vehicle; and ensuring the vehicle is intact.
17. Method as claimed in claim 16, wherein the method further comprises the step of sealing said medication within a permeable container.
18. Method as claimed in either of claims 16 or 17, wherein the method further comprises the step of sealing said medication within a permeable container during manufacture of said container.
19. Apparatus for mucosal administration of medication substantially as hereinbefore described with reference to the accompanying drawings .
20. Method for administration of medication substantially as hereinbefore described with reference to the accompanying drawings.
PCT/GB2000/002758 1999-07-19 2000-07-18 Apparatus and method for administration of medication WO2001005352A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU60017/00A AU6001700A (en) 1999-07-19 2000-07-18 Apparatus and method for administration of medication

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9916773.6A GB9916773D0 (en) 1999-07-19 1999-07-19 Medication compliance device
GB9916773.6 1999-07-19
GB0002342.4 2000-02-02
GB0002342A GB0002342D0 (en) 1999-07-19 2000-02-02 Apparatus and method for drug administration

Publications (1)

Publication Number Publication Date
WO2001005352A1 true WO2001005352A1 (en) 2001-01-25

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/002758 WO2001005352A1 (en) 1999-07-19 2000-07-18 Apparatus and method for administration of medication

Country Status (2)

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AU (1) AU6001700A (en)
WO (1) WO2001005352A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005097609A1 (en) * 2004-04-08 2005-10-20 Maarten Willem Driessen Chewingbag, a bag for herbal material that can be chewed on
CN105213421A (en) * 2015-10-15 2016-01-06 桂林医学院附属医院 A kind of rinsing the mouth medicated bag for the treatment of buccal cavity fungal infection and preparation method thereof
AT15642U1 (en) * 2017-01-04 2018-03-15 Walter Hohenauer Mag tooth pillows

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3948254A (en) * 1971-11-08 1976-04-06 Alza Corporation Novel drug delivery device
WO1991003271A1 (en) * 1989-09-05 1991-03-21 University Of Utah Research Foundation Apparatus for administering medicaments to mucosal tissue
US5167244A (en) * 1990-01-19 1992-12-01 Kjerstad Randy E Tobacco substitute

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3948254A (en) * 1971-11-08 1976-04-06 Alza Corporation Novel drug delivery device
WO1991003271A1 (en) * 1989-09-05 1991-03-21 University Of Utah Research Foundation Apparatus for administering medicaments to mucosal tissue
US5167244A (en) * 1990-01-19 1992-12-01 Kjerstad Randy E Tobacco substitute

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005097609A1 (en) * 2004-04-08 2005-10-20 Maarten Willem Driessen Chewingbag, a bag for herbal material that can be chewed on
NL1028714C2 (en) * 2004-04-08 2006-11-28 Maarten Willem Driessen A plum bag (a herb bag on which you can chew).
CN105213421A (en) * 2015-10-15 2016-01-06 桂林医学院附属医院 A kind of rinsing the mouth medicated bag for the treatment of buccal cavity fungal infection and preparation method thereof
AT15642U1 (en) * 2017-01-04 2018-03-15 Walter Hohenauer Mag tooth pillows

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Publication number Publication date
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