WO2001007019A3 - Use of n-acetyl-cysteine in the treatment of allergic pathologies of the respiratory tract - Google Patents

Use of n-acetyl-cysteine in the treatment of allergic pathologies of the respiratory tract Download PDF

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Publication number
WO2001007019A3
WO2001007019A3 PCT/EP2000/007036 EP0007036W WO0107019A3 WO 2001007019 A3 WO2001007019 A3 WO 2001007019A3 EP 0007036 W EP0007036 W EP 0007036W WO 0107019 A3 WO0107019 A3 WO 0107019A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
respiratory tract
cysteine
acetyl
allergic pathologies
Prior art date
Application number
PCT/EP2000/007036
Other languages
French (fr)
Other versions
WO2001007019A2 (en
Inventor
Francesco Santangelo
Original Assignee
Zambon Spa
Francesco Santangelo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa, Francesco Santangelo filed Critical Zambon Spa
Priority to AU69859/00A priority Critical patent/AU6985900A/en
Publication of WO2001007019A2 publication Critical patent/WO2001007019A2/en
Publication of WO2001007019A3 publication Critical patent/WO2001007019A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The use of NAC in the manufacture of topical pharmaceutical compositions for the treatment of allergic pathologies of the respiratory tract, more particularly allergic rhinitis and asthma, is described.
PCT/EP2000/007036 1999-07-27 2000-07-21 Use of n-acetyl-cysteine in the treatment of allergic pathologies of the respiratory tract WO2001007019A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU69859/00A AU6985900A (en) 1999-07-27 2000-07-21 Use of n-acetyl-cysteine in the manufacture of topical pharmaceutical compositions for the treatment of allergic pathologies of the respiratory tract

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999MI001653A IT1313567B1 (en) 1999-07-27 1999-07-27 USE OF N-ACETYL-CISTEIN FOR THE PREPARATION OF TOPICAL PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF ALLERGIC PATHOLOGIES OF
ITMI99A001653 1999-07-27

Publications (2)

Publication Number Publication Date
WO2001007019A2 WO2001007019A2 (en) 2001-02-01
WO2001007019A3 true WO2001007019A3 (en) 2001-09-27

Family

ID=11383417

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/007036 WO2001007019A2 (en) 1999-07-27 2000-07-21 Use of n-acetyl-cysteine in the treatment of allergic pathologies of the respiratory tract

Country Status (3)

Country Link
AU (1) AU6985900A (en)
IT (1) IT1313567B1 (en)
WO (1) WO2001007019A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT509045B1 (en) * 2010-01-29 2011-06-15 Planta Naturstoffe Vertriebsges M B H COMPOUNDS FOR THE TREATMENT OF ASTHMA BRONCHIALE
IT1405758B1 (en) * 2010-11-03 2014-01-24 Stewart Italia Srl NAC BASED PHARMACEUTICAL PREPARATION IN HYPERTONIC SOLUTION FOR THE TREATMENT OF RINOFARINGEAL AFFECTIONS
ITNA20110020A1 (en) * 2011-05-03 2012-11-04 Gruppo Farmaimpresa Srl NAC AND MSM PHARMACEUTICAL PREPARATION IN SOLUTION FOR THE TREATMENT OF RINOFARINGEAL AFFECTIONS

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA821525A (en) * 1969-08-26 L. Sheffner Aaron N-acetylcysteine containing composition
EP0504112A2 (en) * 1991-03-14 1992-09-16 Ciba-Geigy Ag Pharmaceutical aerosol formulations
WO1997046243A1 (en) * 1996-06-04 1997-12-11 The Procter & Gamble Company A nasal spray containing an intranasal steroid and an antihistamine
WO1998047497A2 (en) * 1997-04-23 1998-10-29 Fleming & Company, Pharmaceuticals Methods and compositions for the prevention and treatment of immunological disorders, inflammatory diseases and infections
WO1998048839A1 (en) * 1997-04-30 1998-11-05 Warner-Lambert Company Topical nasal antiinflammatory compositions
FR2788436A1 (en) * 1999-01-14 2000-07-21 Pf Medicament Composition useful for treating allergic rhinitis contains phenothiazine derivative in aqueous stabilized with sulfur-containing amino acid derivative

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA821525A (en) * 1969-08-26 L. Sheffner Aaron N-acetylcysteine containing composition
EP0504112A2 (en) * 1991-03-14 1992-09-16 Ciba-Geigy Ag Pharmaceutical aerosol formulations
WO1997046243A1 (en) * 1996-06-04 1997-12-11 The Procter & Gamble Company A nasal spray containing an intranasal steroid and an antihistamine
WO1998047497A2 (en) * 1997-04-23 1998-10-29 Fleming & Company, Pharmaceuticals Methods and compositions for the prevention and treatment of immunological disorders, inflammatory diseases and infections
WO1998048839A1 (en) * 1997-04-30 1998-11-05 Warner-Lambert Company Topical nasal antiinflammatory compositions
FR2788436A1 (en) * 1999-01-14 2000-07-21 Pf Medicament Composition useful for treating allergic rhinitis contains phenothiazine derivative in aqueous stabilized with sulfur-containing amino acid derivative

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 196800, Derwent World Patents Index; AN 1966-39429f, XP002165546 *
DE BACKER, W. ET AL: "Sputum ECP levels in COPD patients decrease after treatment with N- acetylcysteine (NAC.", EUROPEAN RESPIRATORY JOURNAL, (SEPT., 1998) VOL. 12, NO. SUPPL. 28, PP. 225S. MEETING INFO.: EUROPEAN RESPIRATORY SOCIETY ANNUAL CONGRESS GENEVA, SWITZERLAND SEPTEMBER 19-23, 1998 THE EUROPEAN RESPIRATORY SOCIETY., XP000997154 *
KARG F.: "[Courses of treatment of allergic illnesses of the respiratory system of children]. KINDERKUREN BEI ALLERGISCHEN ATEMWEGSERKRANKUNGEN.", ALLERGOLOGIE, (1978) 1/1 (44-49). CODEN: ALLRDI, XP000992555 *
KROEGEL C (REPRINT) ET AL: "PULMONARY IMMUNE CELLS IN HEALTH AND DISEASE - THE EOSINOPHIL LEUKOCYTE.2.", EUROPEAN RESPIRATORY JOURNAL, (APR 1994) VOL. 7, NO. 4, PP. 743-760. ISSN: 0903-1936., UNIV FREIBURG, DEPT PNEUMOL, MED CLIN, HUGSTETTER STR 55, D-79106 FREIBURG, GERMANY (Reprint);UNIV SOUTHAMPTON, DEPT PHYSIOL & PHARMACOL, SOUTHAMPTON, ENGLAND, XP000992539 *
MEIER SYDOW J. ET AL: "[Clinical picture and treatment of exogenously allergic bronchial asthma ]. KLINIK UND THERAPIE DES EXOGEN ALLERGISCHEN ASTHMA BRONCHIALE.", THERAPIEWOCHE, (1975) 25/24 (3368-3379). CODEN: THEWA6, XP000992533 *
NELEMANS F A: "DRUGS USED IN BRONCHIAL ASTHMA AND COUGH.", DUKES, M. N. G. (ED.). SIDE EFFECTS OF DRUGS ANNUAL, VOL. 6: A WORLDWIDE YEARLY SURVEY OF NEW DATA AND TRENDS. XVIII+478P. EXCERPTA MEDICA: AMSTERDAM, NETHERLANDS;ELSEVIER/NORTH-HOLLAND, INC.: NEW YORK, N.Y., USA (1982) 0 (0), P171-172., XP000992514 *
VOLKL K.-P. ET AL: "[Treatment of airway diseases with N- acetylcystein. An open therapeutic observational study involving 2,512 patients]. THERAPIE VON ATEMWEGSERKRANKUNGEN MIT N- ACETYLCYSTEIN. EINE OFENE THERAPIEBEOBACHTUNGSSTUDIE AN 2,512 PATIENTEN.", FORTSCHRITTE DER MEDIZIN, (1992) 110/18 (54-60)., XP002165545 *
YAMASHITA, N. (1) ET AL: "Interleukin (IL)-8 production in eosinophil by the stimulation with granulocyte macrophage-colony stimulating factor (GM-CSF) and tumor necrosis factor (TNF)-alpha and its relationship to NF-kappaB activation.", EUROPEAN RESPIRATORY JOURNAL, (DECEMBER, 1998) VOL. 12, NO. SUPPLEMENT 29 PP. 2S. PRINT. MEETING INFO.: WORLD ASTHMA MEETING BARCELONA, SPAIN DECEMBER 09-13, 1998, XP000997160 *

Also Published As

Publication number Publication date
IT1313567B1 (en) 2002-09-09
ITMI991653A0 (en) 1999-07-27
ITMI991653A1 (en) 2001-01-27
AU6985900A (en) 2001-02-13
WO2001007019A2 (en) 2001-02-01

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