WO2001007568A3 - Muscle cells and their use in cardiac repair - Google Patents
Muscle cells and their use in cardiac repair Download PDFInfo
- Publication number
- WO2001007568A3 WO2001007568A3 PCT/US2000/020129 US0020129W WO0107568A3 WO 2001007568 A3 WO2001007568 A3 WO 2001007568A3 US 0020129 W US0020129 W US 0020129W WO 0107568 A3 WO0107568 A3 WO 0107568A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- muscle cells
- cardiac repair
- subject
- methods
- muscle
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0657—Cardiomyocytes; Heart cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0656—Adult fibroblasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00948918A EP1200559A2 (en) | 1999-07-23 | 2000-07-24 | Muscle cells and their use in cardiac repair |
JP2001512839A JP2003505475A (en) | 1999-07-23 | 2000-07-24 | Muscle cells and their use in heart repair |
AU62346/00A AU770889B2 (en) | 1999-07-23 | 2000-07-24 | Muscle cells and their use in cardiac repair |
CA002378643A CA2378643A1 (en) | 1999-07-23 | 2000-07-24 | Muscle cells and their use in cardiac repair |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14584999P | 1999-07-23 | 1999-07-23 | |
US60/145,849 | 1999-07-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001007568A2 WO2001007568A2 (en) | 2001-02-01 |
WO2001007568A3 true WO2001007568A3 (en) | 2001-08-09 |
Family
ID=22514825
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/020129 WO2001007568A2 (en) | 1999-07-23 | 2000-07-24 | Muscle cells and their use in cardiac repair |
Country Status (6)
Country | Link |
---|---|
US (1) | US6673604B1 (en) |
EP (1) | EP1200559A2 (en) |
JP (3) | JP2003505475A (en) |
AU (1) | AU770889B2 (en) |
CA (1) | CA2378643A1 (en) |
WO (1) | WO2001007568A2 (en) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6110459A (en) * | 1997-05-28 | 2000-08-29 | Mickle; Donald A. G. | Transplants for myocardial scars and methods and cellular preparations |
US6099832A (en) * | 1997-05-28 | 2000-08-08 | Genzyme Corporation | Transplants for myocardial scars |
DE69937888T2 (en) * | 1998-07-31 | 2009-01-02 | Genzyme Corp., Cambridge | Process for the preparation of mesenchymal stem cells |
US20030113301A1 (en) * | 1999-07-23 | 2003-06-19 | Albert Edge | Muscle cells and their use in cardiac repair |
US7166280B2 (en) * | 2000-04-06 | 2007-01-23 | Franco Wayne P | Combination growth factor therapy and cell therapy for treatment of acute and chronic heart disease |
US7291597B2 (en) * | 2000-04-06 | 2007-11-06 | Franco Wayne P | Growth factor therapy mobilization of stem cells into the peripheral blood |
US7288521B2 (en) * | 2000-04-06 | 2007-10-30 | Franco Wayne P | Growth factor therapy mobilization of stem cells into the peripheral blood |
US20100303769A1 (en) * | 2000-04-06 | 2010-12-02 | Franco Wayne P | Combination growth factor therapy and cell therapy for treatment of acute and chronic heart disease |
FR2810045B1 (en) * | 2000-06-07 | 2004-09-03 | Assist Publ Hopitaux De Paris | METHOD FOR OBTAINING CELLULAR CELLULAR POPULATIONS OF MUSCLE ORIGIN AND USES THEREOF |
US7629308B2 (en) * | 2000-07-07 | 2009-12-08 | Board Of Regents, The University Of Texas System | Methods relating to muscle selective calcineurin interacting protein (MCIP) |
WO2003085092A2 (en) * | 2002-04-01 | 2003-10-16 | Law Peter K | Cellular transplantation for heart regeneration |
BR0310011A (en) * | 2002-05-10 | 2005-02-15 | Isolagen Technologies Inc | Tissue repair composition, methods of tissue fabrication, tissue preparation and repair of a tissue defect in a patient, injectable tissue repair composition, tissue fabrication method, and tissue repair device |
ES2198216B1 (en) * | 2002-07-02 | 2005-04-16 | Juan Carlos Instituto Cientifico Y Tecnologico De Navarra, S.A.(67%). | MEANS OF CULTURE OF MOTHER-PROGENITORS CELLS HUMAN AND ITS APPLICATIONS. |
US20040191225A1 (en) * | 2002-08-06 | 2004-09-30 | Dinsmore Jonathan H. | Injection system |
JP4943844B2 (en) * | 2003-08-01 | 2012-05-30 | 株式会社セルシード | 3D tissue structure |
US20050070874A1 (en) * | 2003-09-30 | 2005-03-31 | Hikaru Matsuda | System and method for injecting liquid drug containing biological material |
ES2235640B1 (en) * | 2003-12-17 | 2006-12-16 | Consejo Sup. Investig. Cientificas | MEANS OF CULTURE OF HUMAN PROGENITING CELLS AND USE FOR THE PROLIFERATION OF SUCH CELLS FOR THEIR AUTOMOTIVE TRANSPLANT. |
US20050277124A1 (en) * | 2004-06-10 | 2005-12-15 | White Steven M | Cardiac conduction system cells and uses thereof |
US20060263338A1 (en) * | 2005-03-04 | 2006-11-23 | Jacoby Douglas B | Catheter-based delivery of Skeletal Myoblasts to the Myocardium of Damaged Hearts |
EP1865992A2 (en) * | 2005-03-31 | 2007-12-19 | Mytogen Inc. | Treatment for heart disease |
EP1885185A4 (en) * | 2005-05-09 | 2010-04-07 | Mytogen Inc | Cellular cardiomyoplasty as supportive therapy in patients with heart disease |
AU2007292926A1 (en) | 2006-09-08 | 2008-03-13 | Symphony Medical, Inc. | Intramyocardial patterning for treating localized anomalies of the heart |
WO2008039483A2 (en) | 2006-09-26 | 2008-04-03 | Massachusetts Institute Of Technology | Modified self-assembling peptides |
US20080147007A1 (en) * | 2006-12-19 | 2008-06-19 | Toby Freyman | Delivery device with pressure control |
US20090004155A1 (en) * | 2007-02-26 | 2009-01-01 | Casey Patrick J | Method for treating a mammal having damaged myocardium tissue |
EP2146667A2 (en) | 2007-04-11 | 2010-01-27 | Henry Ford Health System | Cardiac repair, resizing and reshaping using the venous system of the heart |
US20140072599A1 (en) | 2011-02-28 | 2014-03-13 | Osaka University | Cytokine-producing cell sheet and method for using the same |
WO2015152429A1 (en) * | 2014-04-03 | 2015-10-08 | 学校法人獨協学園獨協医科大学 | Transplantation immune response suppression method |
US10556953B2 (en) * | 2015-10-12 | 2020-02-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Agent capable of depleting CD8 T cells for the treatment of myocardial infarction or acute myocardial infarction |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995012979A1 (en) * | 1993-11-08 | 1995-05-18 | The University Of Southern California | Compositions and methods for transduction of cells |
WO1996038543A1 (en) * | 1995-04-20 | 1996-12-05 | Diacrin, Incorporated | Modified cells and methods for inhibiting xenograft rejection |
US5602301A (en) * | 1993-11-16 | 1997-02-11 | Indiana University Foundation | Non-human mammal having a graft and methods of delivering protein to myocardial tissue |
WO1998017784A1 (en) * | 1996-10-18 | 1998-04-30 | Universite Laval | Method for in vitro preconditioning of myoblasts before transplantation |
WO1998027995A1 (en) * | 1996-12-20 | 1998-07-02 | Creative Biomolecules, Inc. | Treatment of mammalian myocardium with morphogen locally, or with morphogenically-treated myogenic precursor cells |
WO1998054301A2 (en) * | 1997-05-28 | 1998-12-03 | Genzyme Corporation | Transplants for myocardial scars and method and cellular preparations therefor |
WO1999066036A1 (en) * | 1998-06-19 | 1999-12-23 | Genzyme Corporation | Transplants for myocardial scars |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5130141A (en) | 1988-05-24 | 1992-07-14 | Law Peter K | Compositions for and methods of treating muscle degeneration and weakness |
US5135915A (en) * | 1988-10-14 | 1992-08-04 | Genentech, Inc. | Method for the treatment of grafts prior to transplantation using TGF-.beta. |
US5143842A (en) | 1988-11-01 | 1992-09-01 | The University Of Colorado Foundation, Inc. | Media for normal human muscle satellite cells |
JP3244696B2 (en) | 1989-06-13 | 2002-01-07 | ザ ボード オブ トラスティーズ オブ ザ リランド スタンフォード ジュニア ユニバーシティー | Isolation, proliferation and differentiation of human muscle cells |
US5538722A (en) | 1989-06-13 | 1996-07-23 | Stanford University | Isolation, growth, differentiation and genetic engineering of human muscle cells |
WO1991011522A1 (en) | 1990-01-26 | 1991-08-08 | Baylor College Of Medicine | MUTATED PROMOTER REGION FROM CHICKEN SKELETAL α-ACTIN GENE |
US5199942A (en) | 1991-06-07 | 1993-04-06 | Immunex Corporation | Method for improving autologous transplantation |
WO1992022636A1 (en) | 1991-06-12 | 1992-12-23 | Smith David A | Method for inducing human myocardial cell proliferation |
US5543318A (en) | 1991-06-12 | 1996-08-06 | Smith; David A. | Method of isolation, culture and proliferation of human atrial myocytes |
US5405772A (en) | 1993-06-18 | 1995-04-11 | Amgen Inc. | Medium for long-term proliferation and development of cells |
US6015671A (en) | 1995-06-07 | 2000-01-18 | Indiana University Foundation | Myocardial grafts and cellular compositions |
US6239172B1 (en) | 1997-04-10 | 2001-05-29 | Nitrosystems, Inc. | Formulations for treating disease and methods of using same |
US5968983A (en) | 1994-10-05 | 1999-10-19 | Nitrosystems, Inc | Method and formulation for treating vascular disease |
CN1477190A (en) | 1994-12-13 | 2004-02-25 | 彼得・K・罗 | Method and relative composition for controlling cell fusion |
US5985653A (en) | 1995-06-07 | 1999-11-16 | Aastrom Biosciences, Inc. | Incubator apparatus for use in a system for maintaining and growing biological cells |
US6096532A (en) | 1995-06-07 | 2000-08-01 | Aastrom Biosciences, Inc. | Processor apparatus for use in a system for maintaining and growing biological cells |
US6228635B1 (en) | 1995-06-07 | 2001-05-08 | Aastrom Bioscience, Inc. | Portable cell growth cassette for use in maintaining and growing biological cells |
US6238908B1 (en) | 1995-06-07 | 2001-05-29 | Aastrom Biosciences, Inc. | Apparatus and method for maintaining and growth biological cells |
CA2225185A1 (en) | 1997-08-11 | 1999-02-11 | Peter K. Law | Myoblast transfer therapy for relieving pain and for treating behavioral and perceptive abnormalities |
US5972013A (en) | 1997-09-19 | 1999-10-26 | Comedicus Incorporated | Direct pericardial access device with deflecting mechanism and method |
US6107034A (en) * | 1998-03-09 | 2000-08-22 | The Board Of Trustees Of The Leland Stanford Junior University | GATA-3 expression in human breast carcinoma |
CA2377270A1 (en) | 1999-06-18 | 2000-12-28 | Advanced Research And Technology Institute, Inc. | Cardiomyocytes with enhanced proliferative potential |
-
2000
- 2000-07-24 WO PCT/US2000/020129 patent/WO2001007568A2/en active IP Right Grant
- 2000-07-24 AU AU62346/00A patent/AU770889B2/en not_active Ceased
- 2000-07-24 JP JP2001512839A patent/JP2003505475A/en active Pending
- 2000-07-24 US US09/624,885 patent/US6673604B1/en not_active Expired - Fee Related
- 2000-07-24 CA CA002378643A patent/CA2378643A1/en not_active Abandoned
- 2000-07-24 EP EP00948918A patent/EP1200559A2/en not_active Ceased
-
2007
- 2007-07-18 JP JP2007187596A patent/JP2007262098A/en not_active Withdrawn
-
2011
- 2011-07-08 JP JP2011152353A patent/JP2011219494A/en not_active Withdrawn
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995012979A1 (en) * | 1993-11-08 | 1995-05-18 | The University Of Southern California | Compositions and methods for transduction of cells |
US5602301A (en) * | 1993-11-16 | 1997-02-11 | Indiana University Foundation | Non-human mammal having a graft and methods of delivering protein to myocardial tissue |
WO1996038543A1 (en) * | 1995-04-20 | 1996-12-05 | Diacrin, Incorporated | Modified cells and methods for inhibiting xenograft rejection |
WO1998017784A1 (en) * | 1996-10-18 | 1998-04-30 | Universite Laval | Method for in vitro preconditioning of myoblasts before transplantation |
WO1998027995A1 (en) * | 1996-12-20 | 1998-07-02 | Creative Biomolecules, Inc. | Treatment of mammalian myocardium with morphogen locally, or with morphogenically-treated myogenic precursor cells |
WO1998054301A2 (en) * | 1997-05-28 | 1998-12-03 | Genzyme Corporation | Transplants for myocardial scars and method and cellular preparations therefor |
WO1999066036A1 (en) * | 1998-06-19 | 1999-12-23 | Genzyme Corporation | Transplants for myocardial scars |
Non-Patent Citations (7)
Title |
---|
CHIU R C -J ET AL: "CELLULAR CARDIOMYOPLASTY: MYOCARDIAL REGENERATION WITH SATELLITE CELL IMPLANTATION", ANNALS OF THORACIC SURGERY,US,NEW YORK, NY, vol. 60, no. 1, 1 July 1995 (1995-07-01), pages 12 - 18, XP002064607 * |
FOSTER R F ET AL: "LAMININ SELECTIVELY PROMOTES THE REPLICATION AND DIFFERENTIATION OF MYOBLASTS", JOURNAL OF CELL BIOLOGY, vol. 105, no. 4 PART 2, 1987, pages 288A, XP000979272, ISSN: 0021-9525 * |
GREPIN C ET AL: "ENHANCED CARDIOGENESIS IN EMBRYONIC STEM CELLS OVEREXPRESSING THE GATA-4 TRANSCRIPTION FACTOR", DEVELOPMENT,COMPANY OF BIOLOGISTS, CAMBRIDGE,,GB, vol. 124, no. 12, June 1997 (1997-06-01), pages 2387 - 2395, XP000857684, ISSN: 0950-1991 * |
LI REN-KE ET AL: "Cell therapy to repair broken hearts.", CANADIAN JOURNAL OF CARDIOLOGY, vol. 14, no. 5, May 1998 (1998-05-01), pages 735 - 744, XP000979215, ISSN: 0828-282X * |
MURRY C E ET AL: "Skeletal myoblast transplantation for repair of myocardial necrosis", JOURNAL OF CLINICAL INVESTIGATION,US,NEW YORK, NY, vol. 98, no. 11, 1 December 1996 (1996-12-01), pages 2512 - 2523, XP002078686, ISSN: 0021-9738 * |
ROBINSON S W ET AL: "ARTERIAL DELIVERY OF GENETICALLY LABELLED SKELETAL MYOBLASTS TO THE MURINE HEART: LONG-TERM SURVIVAL AND PHENOTYPIC MODIFICATION OFIMPLANTED MYOBLASTS", CELL TRANSPLANTATION,US,ELSEVIER SCIENCE, vol. 5, no. 1, 1996, pages 77 - 91, XP002064606, ISSN: 0963-6897 * |
YOON D ET AL: "MYOCARDIAL REGENERATION TRANSPLANTING SATELLITE CELLS INTO DAMAGED MYOCARDIUM", TEXAS HEART INSTITUTE JOURNAL,US,CARDIOVASCULAR SURGICAL RESEARCH LABORATORIES, TEXAS HEART, vol. 22, no. 2, 1995, pages 119 - 125, XP002064605, ISSN: 0730-2347 * |
Also Published As
Publication number | Publication date |
---|---|
AU770889B2 (en) | 2004-03-04 |
US6673604B1 (en) | 2004-01-06 |
JP2007262098A (en) | 2007-10-11 |
JP2011219494A (en) | 2011-11-04 |
EP1200559A2 (en) | 2002-05-02 |
CA2378643A1 (en) | 2001-02-01 |
AU6234600A (en) | 2001-02-13 |
WO2001007568A2 (en) | 2001-02-01 |
JP2003505475A (en) | 2003-02-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2001007568A3 (en) | Muscle cells and their use in cardiac repair | |
WO2004009767A3 (en) | Cell therapy for regeneration | |
WO2003080798A3 (en) | Muscle cells and their use in cardiac repair | |
DK1019493T3 (en) | Preparation of hematopoietic cells from multipotent neural stem cells | |
EP1425390A4 (en) | Materials and methods to promote repair of nerve tissue | |
WO2002008389A3 (en) | Therapeutic angiogenesis by bone marrow-derived cell transplantation in myocardial ischemic tissue and skeletal muscle ischemic tissue | |
BR0210599A (en) | Use of carbon monoxide, method for maintaining an animal cell in vitro, article of manufacture as well as sterile cell medium | |
WO2003096972A3 (en) | Angiogenesis and cardiac tissue engineering with peptide hydrogels and related compositions and methods of use thereof | |
WO2006023803A3 (en) | Methods of administering microparticles combined with autologous body components | |
WO2004101758A3 (en) | Composition for maintaining organ and cell viability | |
IL170221A (en) | Progenitor cells from wharton's jelly of human umbilical cord and methods of obtaining and utilizing same | |
MXPA02007137A (en) | Liver tissue source. | |
WO2002086073A3 (en) | Generation of differentiated tissue from nuclear transfer embryonic stem cells and methods of use | |
WO2003085092A3 (en) | Cellular transplantation for heart regeneration | |
WO2002007749A3 (en) | Device providing regulated growth factor delivery for the regeneration of peripheral nerves | |
HK1096047A1 (en) | Hyaluronic acid derivative-based three-dimensional matrix | |
WO1999062940A3 (en) | Methods of altering cardiac cell phenotype | |
CA2213322A1 (en) | Thiols to promote hematopoietic progenitor cell growth | |
DK0952772T3 (en) | Methods of using mononuclear phagocytes to promote axonal regeneration | |
BR0312365A (en) | Autologous human autologous progenitor mother cell culture medium, methods for the preparation thereof and a composition of human autologous progenitor mother cell and for obtaining autologous human progenitor muscle mother cells, use of an autologous human autologous progenitor culture medium human autologous progenitor mother cells, procedure for obtaining human autologous muscle progenitor mother cells and therapeutic procedure for autologous cell cardiomyoplasty, composition enriched with human autologous muscle progenitor mother cells and pharmaceutical composition | |
DE60213852D1 (en) | PREPARATION OF CELL SUSPENSIONS | |
WO2002017935A3 (en) | A method of transplantation using chemotherapy-treated allogeneic cells that enhance immune responses without graft versus host disease | |
WO2001022978A3 (en) | Autologous marrow stem cell (msc) transplantation for myocardial regeneration | |
WO2005058280A3 (en) | Enoximone formulations and their use in the treatment of cardiac hypertrophy and heart failure | |
WO2003029432A3 (en) | Human mesenchymal progenitor cell |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AU CA JP |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AU CA JP |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2378643 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 62346/00 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2000948918 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 2000948918 Country of ref document: EP |
|
WWG | Wipo information: grant in national office |
Ref document number: 62346/00 Country of ref document: AU |