WO2001008593A3 - Method for inducing hypothermia - Google Patents

Method for inducing hypothermia Download PDF

Info

Publication number
WO2001008593A3
WO2001008593A3 PCT/US2000/021185 US0021185W WO0108593A3 WO 2001008593 A3 WO2001008593 A3 WO 2001008593A3 US 0021185 W US0021185 W US 0021185W WO 0108593 A3 WO0108593 A3 WO 0108593A3
Authority
WO
WIPO (PCT)
Prior art keywords
cooling
methods
slurries
phase
change
Prior art date
Application number
PCT/US2000/021185
Other languages
French (fr)
Other versions
WO2001008593A2 (en
Inventor
Lance B Becker
Hoek Terry Vanden
Kenneth E Kasza
Original Assignee
Lance B Becker
Hoek Terry Vanden
Kenneth E Kasza
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lance B Becker, Hoek Terry Vanden, Kenneth E Kasza filed Critical Lance B Becker
Priority to EP00955344A priority Critical patent/EP1207807A4/en
Priority to AU67563/00A priority patent/AU6756300A/en
Priority to JP2001513331A priority patent/JP2003505190A/en
Publication of WO2001008593A2 publication Critical patent/WO2001008593A2/en
Publication of WO2001008593A3 publication Critical patent/WO2001008593A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02Compresses or poultices for effecting heating or cooling
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/12Devices for heating or cooling internal body cavities
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09KMATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K5/00Heat-transfer, heat-exchange or heat-storage materials, e.g. refrigerants; Materials for the production of heat or cold by chemical reactions other than by combustion
    • C09K5/02Materials undergoing a change of physical state when used
    • C09K5/06Materials undergoing a change of physical state when used the change of state being from liquid to solid or vice versa
    • C09K5/066Cooling mixtures; De-icing compositions
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25CPRODUCING, WORKING OR HANDLING ICE
    • F25C1/00Producing ice
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02Compresses or poultices for effecting heating or cooling
    • A61F2007/0292Compresses or poultices for effecting heating or cooling using latent heat produced or absorbed during phase change of materials, e.g. of super-cooled solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/12Devices for heating or cooling internal body cavities
    • A61F2007/126Devices for heating or cooling internal body cavities for invasive application, e.g. for introducing into blood vessels

Abstract

Systems for phase-change particulate slurry cooling equipment and methods to induce hypothermia in a patient through internal and external cooling are provided. Subcutaneous, intravascular, intraperitoneal, gastrointestinal, and lung methods of cooling are carried out using saline ice slurries or other phase-change slurries compatible with human tissue. Perfluorocarbon slurries or other slurry types compatible with human tissue are used for pulmonary cooling. And traditional external cooling methods are improved by utilizing phase-change slurry materials in cooling caps and torso blankets.
PCT/US2000/021185 1999-08-02 2000-08-02 Method for inducing hypothermia WO2001008593A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP00955344A EP1207807A4 (en) 1999-08-02 2000-08-02 Method for inducing hypothermia
AU67563/00A AU6756300A (en) 1999-08-02 2000-08-02 Method for inducing hypothermia
JP2001513331A JP2003505190A (en) 1999-08-02 2000-08-02 Methods for inducing hypothermic conditions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14675399P 1999-08-02 1999-08-02
US60/146,753 1999-08-02

Publications (2)

Publication Number Publication Date
WO2001008593A2 WO2001008593A2 (en) 2001-02-08
WO2001008593A3 true WO2001008593A3 (en) 2002-03-28

Family

ID=22518854

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/021185 WO2001008593A2 (en) 1999-08-02 2000-08-02 Method for inducing hypothermia

Country Status (5)

Country Link
US (1) US6547811B1 (en)
EP (1) EP1207807A4 (en)
JP (1) JP2003505190A (en)
AU (1) AU6756300A (en)
WO (1) WO2001008593A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9217749B2 (en) 2006-05-31 2015-12-22 Lpath, Inc. Immune-derived moieties reactive against lysophosphatidic acid

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6726708B2 (en) * 2000-06-14 2004-04-27 Innercool Therapies, Inc. Therapeutic heating and cooling via temperature management of a colon-inserted balloon
EP1453524A2 (en) * 2001-12-04 2004-09-08 Minnesota High-Tech Resources, LLC Breathable gas mixtures to change body temperature
US7179279B2 (en) * 2002-09-30 2007-02-20 Medtronic Physio Control Corp. Rapid induction of mild hypothermia
CA2411569A1 (en) * 2002-11-12 2004-05-12 Ross E. Mantle Medical device for the extravascular recirculation of fluid in body cavities at controlled temperature and pressure
US7118591B2 (en) * 2003-04-17 2006-10-10 The University Of Chicago Heat transfer probe
JP2007511468A (en) * 2003-10-03 2007-05-10 ファルマシア コーポレイション Composition of a cyclooxygenase-2 selective inhibitor administered under hypothermic conditions for the treatment of ischemia-mediated central nervous system disorders or injuries
US20050120734A1 (en) * 2003-12-04 2005-06-09 Innercool Therapies, Inc. Induction of hypothermia by infusion of saline slush
US8100123B2 (en) 2004-01-22 2012-01-24 Thermocure, Inc. Respiratory system for inducing therapeutic hypothermia
US20050228359A1 (en) * 2004-04-07 2005-10-13 Doyle Aiden J Method and apparatus for treating acute stroke
WO2005117778A1 (en) * 2004-05-26 2005-12-15 Ardiem Medical, Inc. Apparatus and method for inducing suspended animation using rapid, whole body, profound hypothermia
US20060036302A1 (en) 2004-05-28 2006-02-16 Kasza Kenneth E Methods of inducing protective hypothermia of organs
US20060025755A1 (en) * 2004-07-30 2006-02-02 Jaime Landman Surgical cooling system and method
JP2006141993A (en) * 2004-10-19 2006-06-08 Tohoku Univ Cooling apparatus for internal organs
US20060161232A1 (en) * 2005-01-18 2006-07-20 Kasza, Oras and Son to The University of Chicago Phase-change particulate ice slurry coolant medical delivery tubing and insertion devices
WO2006127897A2 (en) * 2005-05-24 2006-11-30 Uab Research Foundation Surgical delivery devices and methods
US7389653B2 (en) * 2005-09-15 2008-06-24 The University Of Chicago Medical ice slurry production device
US20070130981A1 (en) * 2005-10-31 2007-06-14 Tactical Medical Solutions, Llc Evaporative cooling apparatus for iv fluids
US8192474B2 (en) 2006-09-26 2012-06-05 Zeltiq Aesthetics, Inc. Tissue treatment methods
US9132031B2 (en) 2006-09-26 2015-09-15 Zeltiq Aesthetics, Inc. Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile
EP2117486A1 (en) * 2007-01-26 2009-11-18 Wilson Cook Europe ApS Apparatus and method for cooling the brain using a liquid
WO2008124643A1 (en) * 2007-04-05 2008-10-16 Velomedix, Inc. Device and method for safe access to a body cavity
EP2155300A1 (en) * 2007-04-05 2010-02-24 Velomedix, Inc Automated therapy system and method
US20080269109A1 (en) * 2007-04-30 2008-10-30 Becker Lance B System and method of resuscitation of a mammal
US20080287839A1 (en) 2007-05-18 2008-11-20 Juniper Medical, Inc. Method of enhanced removal of heat from subcutaneous lipid-rich cells and treatment apparatus having an actuator
CA2693774A1 (en) * 2007-07-09 2009-01-15 Velomedix, Inc. Hypothermia devices and methods
US8523927B2 (en) 2007-07-13 2013-09-03 Zeltiq Aesthetics, Inc. System for treating lipid-rich regions
US9004065B2 (en) * 2007-08-14 2015-04-14 Institute “On My-Way” B.V. Device for providing a breathing gas
US8285390B2 (en) 2007-08-21 2012-10-09 Zeltiq Aesthetics, Inc. Monitoring the cooling of subcutaneous lipid-rich cells, such as the cooling of adipose tissue
JP2011502237A (en) * 2007-10-19 2011-01-20 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア System and method for generation of two-phase coolant and determination of its cooling capacity
WO2009117586A2 (en) * 2008-03-19 2009-09-24 The Trustees Of The University Of Pennsylvania System and method for producing and determining cooling capacity of two-phase coolants
US8505315B2 (en) * 2008-04-15 2013-08-13 Uchicago Argonne, Llc Enhanced integrated operation blender based sterile medical ice slurry production device
AU2009313320A1 (en) * 2008-11-07 2010-05-14 Velomedix, Inc. Devices and methods for monitoring core temperature and an intraperitoneal parameter
CN102271741A (en) * 2008-12-02 2011-12-07 热疗公司 Systems and methods for delivery of a breathing gas with fine ice particles
US8603073B2 (en) 2008-12-17 2013-12-10 Zeltiq Aesthetics, Inc. Systems and methods with interrupt/resume capabilities for treating subcutaneous lipid-rich cells
EP2393460A4 (en) * 2009-02-06 2012-06-27 Velomedix Inc Method and apparatus for inducing therapeutic hypothermia
US8608696B1 (en) 2009-02-24 2013-12-17 North Carolina State University Rapid fluid cooling devices and methods for cooling fluids
US9301871B2 (en) 2009-02-26 2016-04-05 Advanced Cooling Therapy, Inc. Devices and methods for controlling patient temperature
ES2575302T3 (en) * 2009-02-26 2016-06-27 Advanced Cooling Therapy, Inc. Devices for controlling patient temperature
US9622909B2 (en) 2009-02-26 2017-04-18 Advanced Cooling Therapy, Inc. Devices and methods for controlling patient temperature
US9326890B2 (en) 2009-02-26 2016-05-03 Advanced Cooling Therapy, Inc. Devices and methods for controlling patient temperature
KR101701137B1 (en) 2009-04-30 2017-02-01 젤티크 애스세틱스, 인코포레이티드. Device, system and method of removing heat from subcutaneous lipid-rich cells
US9314368B2 (en) 2010-01-25 2016-04-19 Zeltiq Aesthetics, Inc. Home-use applicators for non-invasively removing heat from subcutaneous lipid-rich cells via phase change coolants, and associates devices, systems and methods
WO2012006625A2 (en) 2010-07-09 2012-01-12 Velomedix, Inc. Method and apparatus for pressure measurement
US8676338B2 (en) 2010-07-20 2014-03-18 Zeltiq Aesthetics, Inc. Combined modality treatment systems, methods and apparatus for body contouring applications
EP2736581A4 (en) 2011-07-25 2015-11-04 Neurosave Inc Non-invasive systems, devices, and methods for selective brain cooling
CN104010598B (en) 2011-09-05 2015-12-09 库尔诊疗公司 For causing, the hypothermic pogonip stomach of therapeutic is sent, dermal delivery or peritoneum are sent
US9844460B2 (en) 2013-03-14 2017-12-19 Zeltiq Aesthetics, Inc. Treatment systems with fluid mixing systems and fluid-cooled applicators and methods of using the same
US9545523B2 (en) 2013-03-14 2017-01-17 Zeltiq Aesthetics, Inc. Multi-modality treatment systems, methods and apparatus for altering subcutaneous lipid-rich tissue
WO2015019257A1 (en) * 2013-08-05 2015-02-12 Yue Wu Method and system for producing and delivering airless medical ice slurry to induce hypothermia
US10238831B2 (en) 2013-09-08 2019-03-26 Qool Therapeutics, Inc. Temperature measurement and feedback for therapeutic hypothermia
US10575890B2 (en) 2014-01-31 2020-03-03 Zeltiq Aesthetics, Inc. Treatment systems and methods for affecting glands and other targeted structures
US10646265B2 (en) * 2014-02-24 2020-05-12 Cryotherapeutics Gmbh Heat exchanger unit for cryotherapy
EP3113737A4 (en) * 2014-03-07 2017-11-22 ZOLL Circulation, Inc. Endovascular heat exchange systems and methods with blood flow monitoring and notification functions
US10675176B1 (en) 2014-03-19 2020-06-09 Zeltiq Aesthetics, Inc. Treatment systems, devices, and methods for cooling targeted tissue
USD777338S1 (en) 2014-03-20 2017-01-24 Zeltiq Aesthetics, Inc. Cryotherapy applicator for cooling tissue
US10952891B1 (en) 2014-05-13 2021-03-23 Zeltiq Aesthetics, Inc. Treatment systems with adjustable gap applicators and methods for cooling tissue
US10568759B2 (en) 2014-08-19 2020-02-25 Zeltiq Aesthetics, Inc. Treatment systems, small volume applicators, and methods for treating submental tissue
US10935174B2 (en) 2014-08-19 2021-03-02 Zeltiq Aesthetics, Inc. Stress relief couplings for cryotherapy apparatuses
EP3261593B1 (en) 2015-02-23 2021-11-03 Qool Therapeutics, Inc. Systems and methods for endotracheal delivery of frozen particles
WO2017070112A1 (en) 2015-10-19 2017-04-27 Zeltiq Aesthetics, Inc. Vascular treatment systems, cooling devices, and methods for cooling vascular structures
EP3399950A1 (en) 2016-01-07 2018-11-14 Zeltiq Aesthetics, Inc. Temperature-dependent adhesion between applicator and skin during cooling of tissue
US10765552B2 (en) 2016-02-18 2020-09-08 Zeltiq Aesthetics, Inc. Cooling cup applicators with contoured heads and liner assemblies
US10682297B2 (en) 2016-05-10 2020-06-16 Zeltiq Aesthetics, Inc. Liposomes, emulsions, and methods for cryotherapy
US10555831B2 (en) 2016-05-10 2020-02-11 Zeltiq Aesthetics, Inc. Hydrogel substances and methods of cryotherapy
US11382790B2 (en) 2016-05-10 2022-07-12 Zeltiq Aesthetics, Inc. Skin freezing systems for treating acne and skin conditions
BR112019008954A2 (en) 2016-11-02 2019-07-09 J P Velis Christopher devices and methods for generating slurry
US11324673B2 (en) 2016-11-18 2022-05-10 Miraki Innovation Think Tank Llc Cosmetic appearance of skin
WO2018111778A1 (en) * 2016-12-13 2018-06-21 Qool Therapeutics, Inc. Dense phase material transport in pulmonary system
ES2677444B1 (en) * 2017-02-01 2019-05-09 Gamesa Innovation & Technology S L Use of phase change materials to slow the formation of ice or produce de-icing in wind turbines
MX2019011995A (en) 2017-04-05 2020-01-20 Miraki Innovation Think Tank Llc Point of delivery cold slurry generation.
JP7085762B2 (en) 2017-04-05 2022-06-17 ミラキ イノベーション シンク タンク エルエルシー Cold slurry confinement
US11076879B2 (en) 2017-04-26 2021-08-03 Zeltiq Aesthetics, Inc. Shallow surface cryotherapy applicators and related technology
US10500342B2 (en) 2017-08-21 2019-12-10 Miraki Innovation Think Tank Llc Cold slurry syringe
CA3107932A1 (en) 2018-07-31 2020-02-06 Zeltiq Aesthetics, Inc. Methods, devices, and systems for improving skin characteristics

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3504674A (en) * 1966-12-22 1970-04-07 Emil S Swenson Method and apparatus for performing hypothermia
US4872866A (en) * 1987-09-11 1989-10-10 Davis Richard C Medical lavage apparatus
US5514094A (en) * 1994-02-14 1996-05-07 The Anello Corporation Cooling system for ocular infusion solution
US5807318A (en) * 1994-07-28 1998-09-15 Heartport, Inc. Method of perfusing the coronary vasculature

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3425419A (en) 1964-08-08 1969-02-04 Angelo Actis Dato Method of lowering and raising the temperature of the human body
US3987211A (en) 1969-04-28 1976-10-19 Dunn Lyman D Method for making slush products
US4111209A (en) 1977-04-18 1978-09-05 Datascope Corporation Topical hypothermia apparatus and method for treating the human body and the like
US4416281A (en) 1981-03-05 1983-11-22 Guardline Disposables Limited Surgical cushion for cooling an organ
US4474016A (en) 1983-03-04 1984-10-02 Baxter Travenol Laboratories, Inc. Sterile cooling system
US4605006A (en) 1984-02-28 1986-08-12 Minnesota Mining And Manufacturing Company Hypothermic protection pad
US4745922A (en) 1986-07-11 1988-05-24 Taylor Kenneth G Cervical heat transfer and immobilization device
US4934152A (en) * 1989-07-10 1990-06-19 Saniserv Inc. Apparatus and method for producing sterile slush and heated sterile liquid
US5562608A (en) * 1989-08-28 1996-10-08 Biopulmonics, Inc. Apparatus for pulmonary delivery of drugs with simultaneous liquid lavage and ventilation
US5088487A (en) 1990-09-06 1992-02-18 Cecil R. Jackson Body wrap with pocket for pliable frozen composition
US5584804A (en) 1990-10-10 1996-12-17 Life Resuscitation Technologies, Inc. Brain resuscitation and organ preservation device and method for performing the same
US6004662A (en) 1992-07-14 1999-12-21 Buckley; Theresa M. Flexible composite material with phase change thermal storage
US5262055A (en) 1992-10-19 1993-11-16 The University Of Utah Implantable and refillable biohybrid artificial pancreas
US5837003A (en) 1993-02-10 1998-11-17 Radiant Medical, Inc. Method and apparatus for controlling a patient's body temperature by in situ blood temperature modification
US5415222A (en) 1993-11-19 1995-05-16 Triangle Research & Development Corporation Micro-climate cooling garment
US5755756A (en) 1995-09-15 1998-05-26 Freedman, Jr.; Robert J. Hypothermia-inducing resuscitation unit
US5809788A (en) * 1996-03-05 1998-09-22 O.R. Solutions, Inc. Surgical drape for use in forming and collecting surgical slush
US5916242A (en) 1996-11-04 1999-06-29 Schwartz; George R. Apparatus for rapid cooling of the brain and method of performing same
US5902299A (en) 1997-07-29 1999-05-11 Jayaraman; Swaminathan Cryotherapy method for reducing tissue injury after balloon angioplasty or stent implantation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3504674A (en) * 1966-12-22 1970-04-07 Emil S Swenson Method and apparatus for performing hypothermia
US4872866A (en) * 1987-09-11 1989-10-10 Davis Richard C Medical lavage apparatus
US5514094A (en) * 1994-02-14 1996-05-07 The Anello Corporation Cooling system for ocular infusion solution
US5807318A (en) * 1994-07-28 1998-09-15 Heartport, Inc. Method of perfusing the coronary vasculature

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9217749B2 (en) 2006-05-31 2015-12-22 Lpath, Inc. Immune-derived moieties reactive against lysophosphatidic acid

Also Published As

Publication number Publication date
JP2003505190A (en) 2003-02-12
WO2001008593A2 (en) 2001-02-08
US6547811B1 (en) 2003-04-15
AU6756300A (en) 2001-02-19
EP1207807A4 (en) 2005-12-28
EP1207807A2 (en) 2002-05-29

Similar Documents

Publication Publication Date Title
WO2001008593A3 (en) Method for inducing hypothermia
MXPA03005342A (en) Carboxylic acid amide derivatives and their use in the treatment of thromboembolic diseases and tumours.
ITPI20040052A1 (en) CONSTRUCTION SYSTEM FOR THE REALIZATION OF SPORTS, RECREATIONAL AND / OR ORNAMENTAL SURFACES WITH THE USE OF ARTIFICIAL GRASS TECHNOLOGY COMBINED WITH LIVING VEGETABLE COVERS
WO2005010032A3 (en) Replikin peptides and uses thereof
HUP0501189A3 (en) Drinkable preparation comprising ketoprofen and the use thereof in the simultaneous treatment of a group of animals for processes which are accompanied by fever, inflammation and/or pain
CN103355445A (en) Health-care tea containing Muyu stone powder
WO2002024216A3 (en) Method for use of igf-binding protein for selective sensitization of target cells in vivo
IL148128A0 (en) Spherical agglomerates of telithromycin, their preparation process and their use in the preparation of pharmaceutical forms
AU5068700A (en) Ceramic material to be utilized in the field of medicine, use of the same, and method for the production thereof
CN2910155Y (en) Cold dressing waistcoast for hemoptic patient
CN201205163Y (en) Elastic inflatable incubation health cup housing
Pearce Sink or swim
CN110507475A (en) A kind of physiotherapy cushion
CN103479942A (en) Traditional Chinese medicine composition for treating chronic gastritis
CN201316343Y (en) Medical adjustable and controllable cool and hot pack blanket
CN103041221A (en) Traditional Chinese medicine composition for treating acute diarrhoea
AU2000239592A1 (en) Heating system for warming a physiologic fluid to be infused into a patient
CN105250068A (en) Cold paste
CN201171743Y (en) Winter heat-treatment clothes
CN206102815U (en) Wrist cold compress nursing device
CN205234753U (en) Device is treated in medical movable knee joint cold
AU6728801A (en) A novel polypeptide, a human red blood cell adducin alpha subunit 11 and the polynucleotide encoding the polypeptide
AU2003211680A1 (en) Chiral catalyst, process for preparing the same and its use in the oxidative coupling of naphthols
CN1608518A (en) Health soup material
Baruchin et al. Tick simulating a traumatized or infarcting skin growth-ticks can trick

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2000955344

Country of ref document: EP

AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 2000955344

Country of ref document: EP