WO2001009204A3 - Controlled-architecture polymers and use thereof as separation media - Google Patents

Controlled-architecture polymers and use thereof as separation media Download PDF

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Publication number
WO2001009204A3
WO2001009204A3 PCT/US2000/020850 US0020850W WO0109204A3 WO 2001009204 A3 WO2001009204 A3 WO 2001009204A3 US 0020850 W US0020850 W US 0020850W WO 0109204 A3 WO0109204 A3 WO 0109204A3
Authority
WO
WIPO (PCT)
Prior art keywords
controlled
separation media
architecture polymers
architecture
living
Prior art date
Application number
PCT/US2000/020850
Other languages
French (fr)
Other versions
WO2001009204A9 (en
WO2001009204A2 (en
Inventor
Gerrit Klaerner
Miroslav Petro
Didier Benoit
Dominique Charmot
Original Assignee
Symyx Technologies Inc
Gerrit Klaerner
Miroslav Petro
Didier Benoit
Dominique Charmot
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symyx Technologies Inc, Gerrit Klaerner, Miroslav Petro, Didier Benoit, Dominique Charmot filed Critical Symyx Technologies Inc
Publication of WO2001009204A2 publication Critical patent/WO2001009204A2/en
Publication of WO2001009204A3 publication Critical patent/WO2001009204A3/en
Publication of WO2001009204A9 publication Critical patent/WO2001009204A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44747—Composition of gel or of carrier mixture
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent

Abstract

Controlled architecture polymers made preferably with acrylamide type monomers are prepared in living-type or semi-living-type free radical polymerizations, with the architecture preferably being other than linear, such as star, branched, grafted or hyper-branched. The controlled architecture polymers have high weight average molecular weights and low viscosities, which make them particularly useful in replaceable capillary electrophoresis separation media for biological molecules, such as DNA fragments.
PCT/US2000/020850 1999-07-31 2000-07-31 Controlled-architecture polymers and use thereof as separation media WO2001009204A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14693699P 1999-07-31 1999-07-31
US60/146,936 1999-07-31

Publications (3)

Publication Number Publication Date
WO2001009204A2 WO2001009204A2 (en) 2001-02-08
WO2001009204A3 true WO2001009204A3 (en) 2002-08-29
WO2001009204A9 WO2001009204A9 (en) 2002-09-26

Family

ID=22519648

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/020850 WO2001009204A2 (en) 1999-07-31 2000-07-31 Controlled-architecture polymers and use thereof as separation media

Country Status (1)

Country Link
WO (1) WO2001009204A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI225492B (en) † 2000-09-25 2004-12-21 Ciba Sc Holding Ag Composition and process for enhancing controlled free radical polymerization
FR2824562A1 (en) * 2001-05-14 2002-11-15 Bio Merieux Production of heat-sensitive hydrophilic polymer particles useful for isolating biomolecules comprises copolymerizing a heat-sensitive hydrophilic polymer with a functionalized hydrophobic homopolymer
AU2003219972A1 (en) * 2002-03-04 2003-09-22 Symyx Technologies, Inc. Copolymers for use in capillary electrophoretic separation media
CN101844983B (en) * 2010-04-02 2014-07-16 北京大学 Start fluorescent polymer, initiator thereof and preparation methods for start fluorescent polymer and initiator
WO2018200279A1 (en) * 2017-04-24 2018-11-01 University Of Notre Dame Du Lac Tunable electroosmotic flow polymer coated capillary

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0545184A2 (en) * 1991-12-04 1993-06-09 BASF Aktiengesellschaft Block copolymers based on acrylate and methacrylate units
US5290418A (en) * 1992-09-24 1994-03-01 Applied Biosystems, Inc. Viscous electrophoresis polymer medium and method
US5498679A (en) * 1995-03-30 1996-03-12 Xerox Corporation Process for producing telechelic, branched and star thermoplastic resin polymers
US5552028A (en) * 1993-12-17 1996-09-03 The Perkin-Elmer Corporation Polymers for separation of biomolecules by capillary electrophoresis
WO1998001478A1 (en) * 1996-07-10 1998-01-15 E.I. Du Pont De Nemours And Company Polymerization with living characteristics
US5885432A (en) * 1992-11-05 1999-03-23 Soane Biosciences Un-crosslinked polymeric media for electrophoresis
US5919861A (en) * 1995-03-30 1999-07-06 Xerox Corporation Processes for the preparation of branched polymers
WO2000042423A1 (en) * 1999-01-12 2000-07-20 Spectrumedix Corporation Copolymers for capillary gel electrophoresis

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0545184A2 (en) * 1991-12-04 1993-06-09 BASF Aktiengesellschaft Block copolymers based on acrylate and methacrylate units
US5290418A (en) * 1992-09-24 1994-03-01 Applied Biosystems, Inc. Viscous electrophoresis polymer medium and method
US5885432A (en) * 1992-11-05 1999-03-23 Soane Biosciences Un-crosslinked polymeric media for electrophoresis
US5552028A (en) * 1993-12-17 1996-09-03 The Perkin-Elmer Corporation Polymers for separation of biomolecules by capillary electrophoresis
US5498679A (en) * 1995-03-30 1996-03-12 Xerox Corporation Process for producing telechelic, branched and star thermoplastic resin polymers
US5919861A (en) * 1995-03-30 1999-07-06 Xerox Corporation Processes for the preparation of branched polymers
WO1998001478A1 (en) * 1996-07-10 1998-01-15 E.I. Du Pont De Nemours And Company Polymerization with living characteristics
WO2000042423A1 (en) * 1999-01-12 2000-07-20 Spectrumedix Corporation Copolymers for capillary gel electrophoresis

Also Published As

Publication number Publication date
WO2001009204A9 (en) 2002-09-26
WO2001009204A2 (en) 2001-02-08

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