WO2001012101A1 - Multiple material dispensing - Google Patents
Multiple material dispensing Download PDFInfo
- Publication number
- WO2001012101A1 WO2001012101A1 PCT/NZ2000/000155 NZ0000155W WO0112101A1 WO 2001012101 A1 WO2001012101 A1 WO 2001012101A1 NZ 0000155 W NZ0000155 W NZ 0000155W WO 0112101 A1 WO0112101 A1 WO 0112101A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- reservoir
- piston
- expression
- reservoirs
- primary
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
- A61F6/08—Pessaries, i.e. devices worn in the vagina to support the uterus, remedy a malposition or prevent conception, e.g. combined with devices protecting against contagion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M2005/14204—Pressure infusion, e.g. using pumps with gas-producing electrochemical cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/14—Female reproductive, genital organs
- A61M2210/1475—Vagina
Definitions
- the present invention relates to dispensing apparatus for dispensing an agent or its precursor(s), methods of use thereof and related means, methods and applications.
- dispensing apparatus for dispensing an agent or its precursor(s), methods of use thereof and related means, methods and applications.
- an active agent or its precursor(s) whether as a single dose, a continuous dose or as a pulsile dose.
- Instances include microprocessor control active delivery of agents as might be used to release a medicament into a body cavity such as, for example, disclosed in PCT/NZ98/00011.
- a reservoir or barrel having a membrane or piston that separates the formulation of the active agent or its precursor(s) from a gas generating arrangement, eg, a hydrogel and its electrodes.
- the present invention is directed to providing the timing mechanism for dispensing apparatus (preferably which lends itself to an easier manufacturing procedure (as will be described hereinafter in more detail)). It is an object of the present invention to provide such apparatus and related means, methods and procedures.
- the present invention has found there can be an effective staggering of materials to be delivered from a device (once initiated by some act) which thereafter is to continue with its delivery regime without a need for further human input where there is reliance on the movement (preferably rectilinearly) of a member or element having a known movement profile or characteristic as the stagger timing mechanism.
- the invention is a dispensing apparatus capable of expressing material, whether the same or different, from at least two reservoirs, the apparatus being characterised in that actuation means for expressing material from an outlet of a first of said reservoirs (hereafter “primary reservoir”) also directly or indirectly expresses or times the expression of material from the outlet(s) of at least one other said reservoir (hereafter “secondary reservoir(s)”) but only after a predetermined state of expression of the material from said primary reservoir has occurred.
- primary reservoir also directly or indirectly expresses or times the expression of material from the outlet(s) of at least one other said reservoir
- said actuation means for expressing material from said primary reservoir includes a piston (hereafter “primary piston”).
- said at least one said secondary reservoir at least in part includes a piston capable of expressing its material via its outlet.
- said actuation means includes a gas generation unit the gas of which is capable of moving said primary piston.
- said gas generation unit is a resistance circuit actuable to generate gas from the battery providing the powering therefor.
- said gas generation unit includes a hydrogel electrolysed at least in part by a battery powered resistance circuit.
- a switching mechanism is provided to allow the initiation of actuation of said gas generation unit.
- said actuation means includes at least one of the group consisting of a spring, an osmotically expanding material, a chemical reaction, compressed gas, evolved or generated gas(es) and a motor.
- said apparatus is capable of being inserted into a body cavity.
- Preferably deployable members for retention in a target body cavity are provided.
- said apparatus is of a configuration for a target mammal with retention features for intra vaginal use. See, for example, US Patent 4,091,807, WO 99/07346, WO 95/13760, WO 98/33452 and WO 96/29025.
- At least one of the materials to be expressed is a liquid or liquid formulation.
- At least one of the materials to be expressed is in the form of a solid or a solids formulation.
- At least one of said outlets is sealed, plugged or otherwise closed yet is openable under the forces to act thereon as the associated material is pressed for expression out of such outlet(s).
- At least one of said secondary reservoirs has its material expressible under the action of gas from said gas generation unit bypassing or ducting through said primary piston once the primary piston has moved a predetermined amount.
- one of said secondary reservoirs has its material expressible under the action of said primary piston coming into contact with and driving a material expressing piston of a said secondary reservoir.
- said primary piston carries a magnet capable of switch actuation for a circuit in turn, once actuated, to cause movement of means to express material from at least one said secondary reservoir.
- said primary piston using a magnet/reed switch interaction can cause, using at least one of the group defined in claim 8, an expression of the material from at least one said secondary reservoir.
- the invention is as previously defined substantially as herein described with reference to any example thereof and/or any of the accompanying drawings.
- the invention is a dispensing apparatus comprising or including an assembly defining partitioned chambers where the partitioning member can be moved by gas pressure increase(s) in one chamber to reduce the volume of the other chamber, a battery powered circuit actuable to generate gas within or for said one chamber, at least one assembly defining at least one material containing reservoir with an outlet (sealed, plugged or otherwise optionally closed) it or each capable of being reduced in volume by a piston, wherein at least one said piston of a said material containing reservoir is moved to express the associated material only once, under the action of said gas generation, said partitioning member has moved a predetermined amount.
- said partitioned chambers have a piston as its partitioning member.
- said one chamber of said partitioned chamber to reduce in volume has an outlet (sealed or otherwise) and contains a material expressible out of said chamber as said volume is reduced.
- the invention is a dispensing apparatus comprising or including an assembly defining partitioned chambers where the partitioning member can be moved to reduce the volume of the other chamber, at least one assembly defining at least one material containing reservoir with an outlet (sealed, plugged or otherwise optionally closed) it or each capable of being reduced in volume by a piston, wherein at least one said piston of a said material containing reservoir is moved to express the associated material only once said partitioning member has moved a predetermined amount.
- said partitioning member is movable by mans of at least one of the group consisting of a spring, an osmotically expanding material, a chemical reaction, compressed gas, evolved or generated gas(es) and a motor.
- a said piston of a said material containing reservoir is movable by means of at least one of the group consisting of a spring, an osmotically expanding material, a chemical reaction, compressed gas, evolved or generated gas(es) and a motor.
- said partitioned chambers have a piston as its partitioning member.
- said one chamber of said partitioned chamber to reduce in volume has an outlet (sealed or otherwise) and contains a material expressible out of said chamber as said volume is reduced.
- the invention is a multiple material dispensing apparatus having a primary reservoir containing a first material expressible via an outlet under the action of a primary piston, and at least one secondary reservoir itself containing a material to be dispensed via an outlet under the action of a secondary piston, wherein said secondary piston is actuable directly by said primary piston after an at least partial expression of the material of the primary reservoir.
- the invention is a dispensing apparatus capable of expressing materials, whether the same or different, from at least two reservoirs, the apparatus being characterised in that a piston (hereafter “primary piston”) in use will express or cause the expression at least some material from a reservoir and that piston, directly or indirectly, activates or causes the expression of at least some material from at least one other reservoir, the relative timing of the at least partial emptying of the reservoirs between or amongst the reservoirs being predetermined but nonetheless being dependent on said piston and its travel.
- a piston hereafter "primary piston” in use will express or cause the expression at least some material from a reservoir and that piston, directly or indirectly, activates or causes the expression of at least some material from at least one other reservoir, the relative timing of the at least partial emptying of the reservoirs between or amongst the reservoirs being predetermined but nonetheless being dependent on said piston and its travel.
- the invention is a dispensing apparatus capable of expressing material, whether the same or different, from at least two reservoirs in a delayed manner, the apparatus being characterised in that a member capable in use of moving or being set to move, can, upon predetermined movement occurring to provide the delay or delays, directly or indirectly express or time the expression of material from the outlet(s) of said at least two reservoirs.
- each said reservoir includes a piston.
- the apparatus is also apparatus of any one of claims 1 to 29.
- said member in use capable of moving moves under the influence of at least one of the group consisting of a spring, an osmotically expanding material, a chemical reaction, compressed gas, evolved or generated gas(es) and a motor.
- said delays are staggered.
- said member capable in use of moving or being set to move is a piston capable of expressing material from its own reservoir.
- said apparatus is in the form of a bolus or intra vaginal device, eg; for use as a bolus.
- said apparatus is adapted for release of active ingredients into an environment.
- the invention consists in a dispensing apparatus capable of expressing materials, whether the same or different, from at least two reservoirs, the apparatus being characterised in that a piston in use that can be initiated to move or which, in its in use site, can move, will express or cause the expression of at least some material from a reservoir and that primary piston also, directly or indirectly, activates or causes the expression of at least some material from at least one other reservoir.
- the expression of at least some material from at least one other reservoir is under the action of a piston in turn moved, initiated to move or allowed to move by the state of movement of the primary piston.
- the invention consists in a device for intraruminal, intra vaginal, or the like body cavity use capable of expressing materials, whether the same or different, from at least two reservoirs, wherein the apparatus is characterised in that a piston in use will express at least some material from a reservoir and that piston directly or indirectly, activates or causes the expression of at least some material from at least one other reservoir.
- the invention is an intra vaginal device having (i) a progesterone containing material in a primary reservoir, and
- said device has four reservoirs to release in sequence, reliant on said member's movement
- said device is also a device as previously defined.
- said device is a bolus for use in a ruminant having in separate reservoirs a trace metal (eg; zinc) and an anthelmintic (eg; ivermectin) which is also a device as previously defined.
- a trace metal eg; zinc
- an anthelmintic eg; ivermectin
- the invention is, in a plural reservoir (solids and/or liquid) material dispensing apparatus, the use of a directly or indirectly (eg; through gas generation) driven member capable after initiation of progressive movement having predetermined travel characteristics as the initiator and/or force providing member for time staggered expression of material from the reservoirs.
- a directly or indirectly (eg; through gas generation) driven member capable after initiation of progressive movement having predetermined travel characteristics as the initiator and/or force providing member for time staggered expression of material from the reservoirs.
- the invention is the use of a member initiable to move
- said member in acting as the timing element said member applies directly or indirectly force to an expression piston of at least one reservoir.
- said member is itself an expression piston of a material containing reservoir.
- the invention is a method of, at least in part, serially or sequentially expressing materials from a delivery device, said method comprising actuating a battery powered device to move an element thereof in a substantially known manner to thereby, with delay of such travel, to act, staggered with respect to time, upon a material expression component of each material containing reservoir to thereby express such material via an outlet.
- the invention is a method of stagger expressing materials from a delivery device, said method comprising setting, actuating or initiating the device to move an element thereof, firstly, to commence (directly or indirectly) materially expression from a first reservoir of the device, and secondly, after the element has traveled a predetermined distance and as it continues to travel, to commence (directly or indirectly) material expression from another material containing reservoir.
- the invention is a method of patterning the delivery of plural materials into a body cavity of an animal which comprises or includes the steps of introducing into a said cavity a device containing said plural materials, discharging at least one of said plural materials from a reservoir under the action of a plunger which reduces the volume of a reservoir available therefor sometime after the initiation of the device, and, by (direct or indirect) interaction with said plunger subsequently discharging at least one other material of the device from that material's reservoir within the device.
- said device is an intra vaginal device.
- said plunger is moved under the action of a gas generation unit.
- said action with said plunger is by abutment with a piston to discharge said at least one other material.
- said interaction with said plunger involves a bypass for a gas but moves said plunger to then in turn act directly upon a piston for discharging said at least one other material.
- said interaction is indirect and involves magnetic switching.
- said device is a bolus or an intra vaginal device and includes means of variable geometry deployable from an insertion condition to a retention condition.
- said method is performed using, as said device, apparatus as previously defined.
- the present invention consists in a dispensing apparatus capable of expressing materials, whether the same or different, from at least two reservoirs, the apparatus being characterised in that a piston in use will express or cause the expression at least some material from a reservoir and that piston, directly or indirectly, activates or causes the expression of at least some material from at least one other reservoir, the relative timing of the at least partial emptying of the reservoirs between or amongst the reservoirs being predetermined but nonetheless being dependent on said piston and its travel.
- the expressions are linked timewise to the travel of the piston.
- the apparatus is for use as a bolus or as an intra vaginal device.
- Other uses could be for timed release of actives into any environment, eg; fishtanks, lubricants into bearings, etc.
- the expressions are linked timewise to the travel of the piston.
- said apparatus is of a kind where the piston of said first reservoir advances without rotation. In other forms it may rotate.
- the advancement of the piston of the first reservoir is under the action of a gas and/or an activated electrical circuit.
- the material of at least the first reservoir is a fluid.
- that fluid is a liquid.
- the liquid is or contains an active ingredient (whether solid or not).
- the material may be a gas or a mixture of a gas and liquid. Any such liquids may include a solids content and/or itself is a mixture of multiple liquids.
- the material to be expressed from a reservoir can be a solid or almost a solid, eg loose powders, a gel, a capsule, or the like.
- At least one and preferably each of the reservoirs is provided with a closed outlet capable of being opened under the direct or indirect action on the contents of the associated reservoir, eg, as would be the case with, for example, a waxed or frangible seal.
- said apparatus has the piston thereof movable under the action of a gas which is generated upon the device being switch activated, eg, at the time of insertion.
- the gas may be generated from a hydrogel or the like using an electrolysis dependent gas generation circuit capable of being activated.
- said gas is generated directly from the energisation of a circuit including a gas generation battery.
- the first reservoir may in turn discharge its content onto a down stream reservoir, eg utilising as a piston therebetween a seal between the materials for the purpose of discharging first material from the second reservoir.
- the piston may time (eg by magnetic interaction) some energisation of a release circuit forming part of a release arrangement of another reservoir.
- Figure 1 shows a hybrid apparatus in accordance with the present invention where there can be an actuation of the device and some control of a discharge sequence of materials from different reservoirs in a pre-determined manner
- Figures 2 A to 2D shows a sequence of materials expression using a device substantially similar to that of Figure 1 with both a piston/needle and piston/piston interaction for the delayed deliveries
- Figures 3 A to 3B in a similar manner to that of Figures 2A to 2D shows an expression sequence again with a device similar to that of Figure 1 but this time with a primary piston interacting directly on a piston of at least two of the secondary reservoirs with stagger timing as to delivery therefrom,
- Figure 4 shows the rate of vehicle delivery for a device of a kind as shown in Figure 1 in a simplified form
- Figure 5 shows the effect of the needle and piston (diamond) or piston only
- Figure 6 shows the effect of short secondary piston (circle) or long secondary piston (square) upon flow rate at 38 °C of vehicle from the infusion reservoir of a device possessing piston/piston interaction options as shown in options of Figures 2A to 2D and more particularly 3 A to 3D,
- Figure 7 shows a plot to show the effect of the static resistance of the piston and seals of a primary bolus reservoir and the subsequent influence thereof on time lag between initiation of hydrogen production of a gas cell and release of a primary bolus reservoir dosage unit and vehicle from the infusion reservoir, Figure 7 showing the release of fluorescence from a primary bolus reservoir with a high static pressure piston,
- Figure 8 is a similar plot to that of Figure 7 but in respect of a low static pressure piston
- Figure 9 shows the use of an interaction with the piston to time subsequent discharges
- Figures 10A through 10D show a device having (shown diagrammatically and not in an assembly) a sequence of three secondary reservoirs capable of being activated by passage past, for example, a read switch of a magnet that moves as the moveable element or member, and
- Figure 11 shows a most preferred form of the present invention having materials discharged from the primary reservoir under the action of a primary piston (moved by gas being generated after initiation), the primary piston subsequently, by abutment on piston extensions of two secondary reservoirs, leading to the staggered discharge from the secondary reservoirs.
- the preferred propulsion mechanism for the main piston is a gas generating or hydrogel cell, other mechanisms may be used.
- main piston or secondary pistons, especially following activations by a main piston via a magnet and reed switch
- mechanisms that may be employed to drive the main piston (or secondary pistons, especially following activations by a main piston via a magnet and reed switch) include; a spring,
- an osmotically expanding material e.g. gelatin
- Figure 1 shows a main barrel or reservoir having an outlet the upper end adjacent to smaller reservoirs.
- a main piston 2 acts to dispense the contents from a main reservoir 3 as a result of an increase in pressure from a gas cell 4 that is activated by a switch 5.
- the contents of the main reservoir act upon the primary piston 6 of a primary reservoir 7 to dispense the primary reservoir contents after the rupture of the primary reservoir seal.
- the primary piston may also act directly upon the rod and piston 8 to dispense the contents of a terminal reservoir 9.
- the primary piston may also be pierced by a needle 10 thereby enabling gas to by- pass the main piston and act upon a piston 11.
- Figure 1 One configuration of the Figure 1 option is better presented in Figures 2 A to 2D.
- a dosage unit e.g. tablet
- FIG. 4 shows the rate of vehicle delivery from a device similar to that represented in Figure 1 with the exception that the needle 10 and piston 11 are absent.
- the arrow represents the time point at which the infusion piston comes into contact with the secondary piston and/or needle.
- the vehicle was aqueous 2% HPMC held at 38°C.
- the interaction between the needle and piston as shown by the diamonds and the interaction between the piston with a piston is shown with the squares.
- the vehicle is aqueous 4% HPMC at 38 °C and the circles depict the effect of a short piston whilst the square depict the effect of a long piston.
- the piston options are those depicted as piston to piston interactions in Figures 2A to 2D and 3A to 3D.
- the static resistance of the piston and seals of the primary bolus reservoir influences the time lag between initiation of hydrogen production by the gas cell and release of the primary bolus reservoir dosage unit and vehicle from the infusion reservoir (see Figure 7 and 8 and Table 1).
- Table 1 Effect of high static pressure (2 points of contact between piston and reservoir walls) and low static pressure (1 point of contact between piston and reservoir walls) upon the lag between initiating hydrogen production by the gas cell and release of a dosage unit from the primary bolus reservoir.
- Choice of appropriate rod lengths for the bolus chamber delivery mechanism and static pressure of the pistons within each individual reservoir would enable the selection of any desired delivery rate and profile.
- Figure 7 shows the release of fluorescence from the primary bolus reservoir with a high static pressure piston whilst Figure 8 shows the release of fluorescence from the primary reservoir with a low static pressure piston.
- Figure 9 shows a main barrel or reservoir 1 in which a piston 2 containing a magnetic material 3 is enabled to migrate within the main barrel as a result of an increase in pressure from a gas cell 4.
- the magnet material is able to activate individual sensors 5 or sensor part or an array 6 which in turn control the action of a device(s) 7 and/or 8.
- a preferred configuration is detailed in Figure 11 and Table 2. It consists of a cylinder that is divided by piston 13 in reservoir 14, containing the formulation, and part 15, containing the gas and the gas producing components. The action of piston 13 upon the formulation contained in reservoir 14 causes piston 16 to expel the contents of reservoir 17 following the rupture of a seal 18.
- piston 13 migrates towards the outlet of reservoir 17 thereby coming into contact with rod 19.
- Rod 19 acting under the influence of piston 13 drives piston 20 to expel the contents of reservoir 21 following the rupture of seal 22.
- Secondary reservoir contents • Primary - a tablet, liquid or semi-solid dosage unit of 10 mg oestradiol benzoate (ODB)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00955189A EP1210030A1 (en) | 1999-08-18 | 2000-08-09 | Multiple material dispensing |
US10/048,981 US7083590B1 (en) | 1999-08-18 | 2000-08-09 | Multiple material dispensing |
JP2001516448A JP2003506192A (en) | 1999-08-18 | 2000-08-09 | Multi-substance distribution |
AU67421/00A AU757372B2 (en) | 1999-08-18 | 2000-08-09 | Multiple material dispensing |
CA002380589A CA2380589C (en) | 1999-08-18 | 2000-08-09 | Multiple material dispensing |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ337318 | 1999-08-18 | ||
NZ337318A NZ337318A (en) | 1999-08-18 | 1999-08-18 | Dispensing apparatus for dispensing same or different materials for at least two reservoirs |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2001012101A1 true WO2001012101A1 (en) | 2001-02-22 |
Family
ID=19927455
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/NZ2000/000155 WO2001012101A1 (en) | 1999-08-18 | 2000-08-09 | Multiple material dispensing |
Country Status (9)
Country | Link |
---|---|
US (1) | US7083590B1 (en) |
EP (1) | EP1210030A1 (en) |
JP (1) | JP2003506192A (en) |
AR (1) | AR025289A1 (en) |
AU (1) | AU757372B2 (en) |
CA (1) | CA2380589C (en) |
MY (1) | MY128526A (en) |
NZ (1) | NZ337318A (en) |
WO (1) | WO2001012101A1 (en) |
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Citations (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3923058A (en) * | 1972-05-19 | 1975-12-02 | Kendall & Co | Multi-chamber syringe |
US4091807A (en) | 1976-11-04 | 1978-05-30 | Dickinson Ben Wade O Iii | Intra-vaginal device and method of use |
US4413991A (en) * | 1982-03-18 | 1983-11-08 | Schmitz John B | Dual dose ampule |
US4439184A (en) * | 1982-05-03 | 1984-03-27 | Concord Laboratories, Inc. | Two-dose syringe |
WO1991016094A1 (en) * | 1990-04-12 | 1991-10-31 | Survival Technology, Inc. | Dispersion multi-chamber auto-injector |
US5090963A (en) * | 1990-10-19 | 1992-02-25 | Product Development (Z.G.S.) Ltd. | Electrochemically driven metering medicament dispenser |
WO1992007612A1 (en) * | 1990-10-29 | 1992-05-14 | Alza Corporation | Osmotically driven syringe with programmable agent delivery |
WO1994001165A1 (en) | 1992-07-13 | 1994-01-20 | Elan Medical Technologies Limited | Medication administering device |
US5290259A (en) * | 1993-02-18 | 1994-03-01 | Ultradent Products, Inc. | Double syringe delivery system |
WO1995013760A1 (en) | 1993-11-15 | 1995-05-26 | Commonwealth Scientific And Industrial Research Organisation | Gas driven controlled release device |
WO1996008280A1 (en) * | 1994-09-16 | 1996-03-21 | River Medical, Inc. | Apparatus and methods for multiple fluid infusion |
WO1996029025A1 (en) | 1995-03-23 | 1996-09-26 | Advanced Animal Technology Limited | Substance delivery device |
EP0737484A2 (en) * | 1995-04-12 | 1996-10-16 | Nissho Corporation | Prefilled syringe for injection of two liquids |
WO1996037189A1 (en) * | 1995-05-26 | 1996-11-28 | Alza Corporation | Osmotic device with high drug loading and delayed activation of drug delivery |
US5599312A (en) * | 1992-12-01 | 1997-02-04 | Higashikawa; Tetsuro | Syringe |
WO1997040776A1 (en) * | 1996-05-01 | 1997-11-06 | Dec International Nz Limited | Synchronising of animal oestrus and intra vaginal devices useful therein |
US5741275A (en) | 1992-06-15 | 1998-04-21 | Wyssmann; Max | Device for the intentional and controllable distribution of a liquid or viscous material |
WO1998033452A1 (en) * | 1997-02-03 | 1998-08-06 | Dec International Nz Limited | Active delivery device and related procedures |
WO1999007346A1 (en) | 1997-08-07 | 1999-02-18 | Microlin, L.C. | Implantable gas propelled beneficial agent delivery device |
WO1999012593A2 (en) * | 1997-09-05 | 1999-03-18 | Baxter International Inc. | Electrochemical syringe pump |
WO1999026556A1 (en) * | 1997-11-21 | 1999-06-03 | Interag | Biodegradable intra vaginal devices |
US5989215A (en) * | 1995-01-16 | 1999-11-23 | Baxter International Inc. | Fibrin delivery device and method for forming fibrin on a surface |
WO2000037130A1 (en) * | 1998-12-22 | 2000-06-29 | Winsel, August | Controlled and regulated conveying of fluid mediums by electrochemical gas generation |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2468377A1 (en) * | 1979-11-06 | 1981-05-08 | Bourdon Frederic | SYRINGE OPERATING WITH AN EXTERNAL ENERGY SOURCE |
US4413391A (en) | 1982-08-02 | 1983-11-08 | Albany International Corp. | Resin containing textiles |
US4595583A (en) | 1984-03-19 | 1986-06-17 | Alza Corporation | Delivery system controlled administration of beneficial agent to ruminants |
EP0746356B1 (en) * | 1991-10-24 | 2000-05-17 | Insutech, Incorporated | Gas pressure driven infusion system by hydrogel electrolysis |
US5593552A (en) * | 1993-05-07 | 1997-01-14 | Ceramatec, Inc. | Device for electrochemical generation of gas |
DE4331947C1 (en) | 1993-09-21 | 1994-11-17 | Satzinger Gmbh & Co | Lubricant dispenser for the gas-controlled delivery of a lubricant to a machine |
AU734727B2 (en) * | 1997-12-05 | 2001-06-21 | Interag | Improvements in and/or relating to delivery devices and their use |
NZ329338A (en) | 1998-12-02 | 2000-01-28 | Dec Res | Intra ruminal medicament release device |
-
1999
- 1999-08-18 NZ NZ337318A patent/NZ337318A/en not_active IP Right Cessation
-
2000
- 2000-08-09 US US10/048,981 patent/US7083590B1/en not_active Expired - Lifetime
- 2000-08-09 JP JP2001516448A patent/JP2003506192A/en active Pending
- 2000-08-09 CA CA002380589A patent/CA2380589C/en not_active Expired - Fee Related
- 2000-08-09 WO PCT/NZ2000/000155 patent/WO2001012101A1/en active IP Right Grant
- 2000-08-09 AU AU67421/00A patent/AU757372B2/en not_active Expired
- 2000-08-09 EP EP00955189A patent/EP1210030A1/en not_active Withdrawn
- 2000-08-14 MY MYPI20003710A patent/MY128526A/en unknown
- 2000-08-16 AR ARP000104227A patent/AR025289A1/en unknown
Patent Citations (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3923058A (en) * | 1972-05-19 | 1975-12-02 | Kendall & Co | Multi-chamber syringe |
US4091807A (en) | 1976-11-04 | 1978-05-30 | Dickinson Ben Wade O Iii | Intra-vaginal device and method of use |
US4413991A (en) * | 1982-03-18 | 1983-11-08 | Schmitz John B | Dual dose ampule |
US4439184A (en) * | 1982-05-03 | 1984-03-27 | Concord Laboratories, Inc. | Two-dose syringe |
WO1991016094A1 (en) * | 1990-04-12 | 1991-10-31 | Survival Technology, Inc. | Dispersion multi-chamber auto-injector |
US5090963A (en) * | 1990-10-19 | 1992-02-25 | Product Development (Z.G.S.) Ltd. | Electrochemically driven metering medicament dispenser |
WO1992007612A1 (en) * | 1990-10-29 | 1992-05-14 | Alza Corporation | Osmotically driven syringe with programmable agent delivery |
US5741275A (en) | 1992-06-15 | 1998-04-21 | Wyssmann; Max | Device for the intentional and controllable distribution of a liquid or viscous material |
WO1994001165A1 (en) | 1992-07-13 | 1994-01-20 | Elan Medical Technologies Limited | Medication administering device |
US5599312A (en) * | 1992-12-01 | 1997-02-04 | Higashikawa; Tetsuro | Syringe |
US5290259A (en) * | 1993-02-18 | 1994-03-01 | Ultradent Products, Inc. | Double syringe delivery system |
WO1995013760A1 (en) | 1993-11-15 | 1995-05-26 | Commonwealth Scientific And Industrial Research Organisation | Gas driven controlled release device |
WO1996008280A1 (en) * | 1994-09-16 | 1996-03-21 | River Medical, Inc. | Apparatus and methods for multiple fluid infusion |
US5989215A (en) * | 1995-01-16 | 1999-11-23 | Baxter International Inc. | Fibrin delivery device and method for forming fibrin on a surface |
WO1996029025A1 (en) | 1995-03-23 | 1996-09-26 | Advanced Animal Technology Limited | Substance delivery device |
EP0737484A2 (en) * | 1995-04-12 | 1996-10-16 | Nissho Corporation | Prefilled syringe for injection of two liquids |
WO1996037189A1 (en) * | 1995-05-26 | 1996-11-28 | Alza Corporation | Osmotic device with high drug loading and delayed activation of drug delivery |
WO1997040776A1 (en) * | 1996-05-01 | 1997-11-06 | Dec International Nz Limited | Synchronising of animal oestrus and intra vaginal devices useful therein |
WO1998033452A1 (en) * | 1997-02-03 | 1998-08-06 | Dec International Nz Limited | Active delivery device and related procedures |
WO1999007346A1 (en) | 1997-08-07 | 1999-02-18 | Microlin, L.C. | Implantable gas propelled beneficial agent delivery device |
WO1999012593A2 (en) * | 1997-09-05 | 1999-03-18 | Baxter International Inc. | Electrochemical syringe pump |
WO1999026556A1 (en) * | 1997-11-21 | 1999-06-03 | Interag | Biodegradable intra vaginal devices |
WO2000037130A1 (en) * | 1998-12-22 | 2000-06-29 | Winsel, August | Controlled and regulated conveying of fluid mediums by electrochemical gas generation |
Cited By (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003065924A1 (en) * | 2002-02-08 | 2003-08-14 | Advanced Animal Technology Limited | Control of a biological function |
EP2308465A3 (en) * | 2009-10-08 | 2011-12-21 | Palo Alto Research Institute Incorporated | Transmucosal drug delivery device and method including chemical permeation enhancers |
US8882748B2 (en) | 2009-10-08 | 2014-11-11 | Palo Alto Research Center Incorporated | Transmucosal drug delivery device and method including chemical permeation enhancers |
US10632294B2 (en) | 2009-10-08 | 2020-04-28 | Palo Alto Research Center Incorporated | Transmucosal drug delivery device and method including chemical permeation enhancers |
US9014799B2 (en) | 2009-10-08 | 2015-04-21 | Palo Alto Research Center Incorporated | Transmucosal drug delivery device and method including electrically-actuated permeation enhancement |
US9017310B2 (en) | 2009-10-08 | 2015-04-28 | Palo Alto Research Center Incorporated | Transmucosal drug delivery device and method including microneedles |
AU2011200392B2 (en) * | 2011-01-31 | 2015-05-28 | Palo Alto Research Center Incorporated | Transmucosal drug delivery device |
CN102641548A (en) * | 2011-02-18 | 2012-08-22 | 帕洛阿尔托研究中心公司 | Device and method for delivering transmucosal drugs including chemical penetration enhancer |
US9717526B2 (en) | 2012-09-27 | 2017-08-01 | Palo Alto Research Center Incorporated | Multiple reservoir drug delivery device and methods |
US9204895B2 (en) | 2012-09-27 | 2015-12-08 | Palo Alto Research Center Incorporated | Multiple reservoir drug delivery device and methods |
US9005108B2 (en) | 2012-09-27 | 2015-04-14 | Palo Alto Research Center Incorporated | Multiple reservoir drug delivery device and methods |
US9999720B2 (en) | 2012-09-27 | 2018-06-19 | Palo Alto Research Center Incorporated | Drug reconstitution and delivery device and methods |
US10596358B2 (en) | 2013-01-15 | 2020-03-24 | Palo Alto Research Center Incorporated | Devices and methods for intraluminal retention and drug delivery |
US9744341B2 (en) | 2013-01-15 | 2017-08-29 | Palo Alto Research Center Incorporated | Devices and methods for intraluminal retention and drug delivery |
US9297083B2 (en) | 2013-12-16 | 2016-03-29 | Palo Alto Research Center Incorporated | Electrolytic gas generating devices, actuators, and methods |
US9801660B2 (en) | 2014-07-31 | 2017-10-31 | Palo Alto Research Center Incorporated | Implantable fluid delivery devices, systems, and methods |
US10278675B2 (en) | 2014-07-31 | 2019-05-07 | Palo Alto Research Center Incorporated | Implantable estrus detection devices, systems, and methods |
US10925644B2 (en) | 2014-07-31 | 2021-02-23 | Palo Alto Research Center Incorporated | Implantable fluid delivery devices, systems, and methods |
US11547447B2 (en) | 2014-07-31 | 2023-01-10 | Palo Alto Research Center Incorporated | Implantable fluid delivery devices, systems, and methods |
CN109395235A (en) * | 2017-11-23 | 2019-03-01 | 黄河科技学院 | Injecting type feeding device for gynemetrics |
CN109395235B (en) * | 2017-11-23 | 2021-07-09 | 黄河科技学院 | A injection formula medicine feeding device for gynaecology and obstetrics |
CN107969348A (en) * | 2017-12-04 | 2018-05-01 | 徐州果姿电子商务有限公司 | A kind of livestock-raising cub device for feeding |
Also Published As
Publication number | Publication date |
---|---|
MY128526A (en) | 2007-02-28 |
AU757372B2 (en) | 2003-02-20 |
AR025289A1 (en) | 2002-11-20 |
EP1210030A1 (en) | 2002-06-05 |
US7083590B1 (en) | 2006-08-01 |
CA2380589C (en) | 2008-09-23 |
AU6742100A (en) | 2001-03-13 |
JP2003506192A (en) | 2003-02-18 |
NZ337318A (en) | 2002-07-26 |
CA2380589A1 (en) | 2001-02-22 |
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