WO2001012790A3 - Isomerase proteins - Google Patents

Isomerase proteins Download PDF

Info

Publication number
WO2001012790A3
WO2001012790A3 PCT/US2000/022518 US0022518W WO0112790A3 WO 2001012790 A3 WO2001012790 A3 WO 2001012790A3 US 0022518 W US0022518 W US 0022518W WO 0112790 A3 WO0112790 A3 WO 0112790A3
Authority
WO
WIPO (PCT)
Prior art keywords
isom
provides
isomerase proteins
expression
isomerase
Prior art date
Application number
PCT/US2000/022518
Other languages
French (fr)
Other versions
WO2001012790A2 (en
Inventor
Olga Bandman
Dyung Aina M Lu
Henry Yue
Bao Tran
Jennifer L Hillman
Mariah R Baughn
Preeti Lal
Y Tom Tang
Original Assignee
Incyte Genomics Inc
Olga Bandman
Dyung Aina M Lu
Henry Yue
Bao Tran
Jennifer L Hillman
Mariah R Baughn
Preeti Lal
Y Tom Tang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc, Olga Bandman, Dyung Aina M Lu, Henry Yue, Bao Tran, Jennifer L Hillman, Mariah R Baughn, Preeti Lal, Y Tom Tang filed Critical Incyte Genomics Inc
Priority to EP00957506A priority Critical patent/EP1206553A2/en
Priority to CA002382019A priority patent/CA2382019A1/en
Priority to AU69113/00A priority patent/AU6911300A/en
Priority to JP2001517675A priority patent/JP2003526340A/en
Publication of WO2001012790A2 publication Critical patent/WO2001012790A2/en
Publication of WO2001012790A3 publication Critical patent/WO2001012790A3/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90Isomerases (5.)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Abstract

The invention provides human isomerases (ISOM) and polynucleotides which identify and encode ISOM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of ISOM.
PCT/US2000/022518 1999-08-17 2000-08-16 Isomerase proteins WO2001012790A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP00957506A EP1206553A2 (en) 1999-08-17 2000-08-16 Isomerase proteins
CA002382019A CA2382019A1 (en) 1999-08-17 2000-08-16 Isomerase proteins
AU69113/00A AU6911300A (en) 1999-08-17 2000-08-16 Isomerase proteins
JP2001517675A JP2003526340A (en) 1999-08-17 2000-08-16 Isomerase protein

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14938899P 1999-08-17 1999-08-17
US60/149,388 1999-08-17

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10049797 A-371-Of-International 2002-02-12
US10/729,473 Division US20040185529A1 (en) 1999-08-17 2003-12-05 Isomerases proteins

Publications (2)

Publication Number Publication Date
WO2001012790A2 WO2001012790A2 (en) 2001-02-22
WO2001012790A3 true WO2001012790A3 (en) 2001-10-25

Family

ID=22530062

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/022518 WO2001012790A2 (en) 1999-08-17 2000-08-16 Isomerase proteins

Country Status (5)

Country Link
EP (1) EP1206553A2 (en)
JP (1) JP2003526340A (en)
AU (1) AU6911300A (en)
CA (1) CA2382019A1 (en)
WO (1) WO2001012790A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5479069A (en) * 1994-02-18 1995-12-26 Winsor Corporation Planar fluorescent lamp with metal body and serpentine channel
DE19958680A1 (en) * 1999-12-06 2001-06-13 Multigene Biotech Gmbh cDNA sequences of two interactors FANCIP4 and FANCIP5 of the Fanconi anemia proteins of the complementation groups A and C.
WO2001096392A2 (en) * 2000-06-15 2001-12-20 Millennium Pharmaceuticals, Inc. 22109, a novel human thioredoxin family member and uses thereof
AU2001243449A1 (en) * 2000-03-07 2001-09-17 Millenium Pharmaceuticals, Inc. 22105, a novel human thioredoxin family member and uses thereof
WO2002020731A2 (en) * 2000-09-08 2002-03-14 Bayer Aktiengesellschaft Regulation of human protein disulfide isomerase-like enzyme

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995021861A1 (en) * 1994-02-15 1995-08-17 Merck & Co., Inc. Fk-506 cytosolic binding protein
WO1997043426A1 (en) * 1996-05-16 1997-11-20 Incyte Pharmaceuticals, Inc. Human protein disulfide isomerase
US5723311A (en) * 1995-06-02 1998-03-03 Human Genome Sciences, Inc. Human DNA topoisomerase I α

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995021861A1 (en) * 1994-02-15 1995-08-17 Merck & Co., Inc. Fk-506 cytosolic binding protein
US5723311A (en) * 1995-06-02 1998-03-03 Human Genome Sciences, Inc. Human DNA topoisomerase I α
WO1997043426A1 (en) * 1996-05-16 1997-11-20 Incyte Pharmaceuticals, Inc. Human protein disulfide isomerase

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
APEL T W ET AL.: "The ribose 5-phosphate isomerase-encoding gene is located immediately downstream from that encoding murine immunoglobulin kappa", GENE, vol. 156, no. 2, 1995, pages 191 - 197, XP004042354 *
DATABASE EMBL EMBL; 24 May 1997 (1997-05-24), HILLIER L ET AL.: "zw47e12.s1 Soares_total_fetus_Nb2HF8_9w Homo sapiens cDNA clone IMAGE:773230 3' similar to SW:RPIA_HUMAN P49247 RIBOSE 5-PHOSPHATE ISOMERASE ;, mRNA sequence", XP002160177 *
DATABASE EMBL EMBL; 3 June 1999 (1999-06-03), STRAUSBERG R: "wd85g04.x1 NCI_CGAP_Lu24 Homo sapiens cDNA clone IMAGE:2338422 3', mRNA sequence", XP002160176 *

Also Published As

Publication number Publication date
WO2001012790A2 (en) 2001-02-22
AU6911300A (en) 2001-03-13
JP2003526340A (en) 2003-09-09
EP1206553A2 (en) 2002-05-22
CA2382019A1 (en) 2001-02-22

Similar Documents

Publication Publication Date Title
WO2001012662A3 (en) Membrane associated proteins
WO1999061471A3 (en) Human transmembrane proteins
WO2001007628A3 (en) Human synthetases
WO2000015793A3 (en) Human gpcr proteins
WO2000018922A3 (en) Human carbohydrate-associated proteins
WO2000034477A3 (en) Neuron-associated proteins
WO1999058692A3 (en) Human apoptosis associated proteins
WO2000009709A3 (en) Proteases and associated proteins
WO2001007612A3 (en) Receptors and associated proteins
WO2001005970A3 (en) Gtp-binding protein associated factors
WO2000052151A3 (en) Human secretory proteins
WO2000078953A3 (en) Human transport proteins
WO2000014251A3 (en) Human transferase proteins
WO2000044900A3 (en) Nucleic-acid binding proteins
WO2001007471A3 (en) Cell cycle and proliferation proteins
WO2000028032A3 (en) Human cell surface receptor proteins
WO2000056891A3 (en) Human transmembrane proteins
WO1999058558A3 (en) Cell signaling proteins
WO1999061614A3 (en) Human socs proteins
WO2001044448A3 (en) Human oxidoreductase proteins
WO2000031263A3 (en) Gtpase associated proteins
WO2000028045A3 (en) Human hydrolase proteins
WO2000065054A3 (en) Human membrane-associated proteins
WO2001012790A3 (en) Isomerase proteins
WO2000008155A3 (en) Human receptor-associated proteins

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 10049797

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2382019

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2000957506

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2000957506

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 2000957506

Country of ref document: EP