WO2001014850A1 - Centrifuge tube apparatus - Google Patents

Centrifuge tube apparatus Download PDF

Info

Publication number
WO2001014850A1
WO2001014850A1 PCT/US2000/040728 US0040728W WO0114850A1 WO 2001014850 A1 WO2001014850 A1 WO 2001014850A1 US 0040728 W US0040728 W US 0040728W WO 0114850 A1 WO0114850 A1 WO 0114850A1
Authority
WO
WIPO (PCT)
Prior art keywords
tube
separator
passage
assembly according
pipette
Prior art date
Application number
PCT/US2000/040728
Other languages
French (fr)
Inventor
Leland L. Bass
Original Assignee
Bass Leland L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bass Leland L filed Critical Bass Leland L
Priority to AU80332/00A priority Critical patent/AU8033200A/en
Publication of WO2001014850A1 publication Critical patent/WO2001014850A1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5021—Test tubes specially adapted for centrifugation purposes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/26—Separation of sediment aided by centrifugal force or centripetal force
    • B01D21/262—Separation of sediment aided by centrifugal force or centripetal force by using a centrifuge
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2221/00—Applications of separation devices
    • B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues

Definitions

  • Prior art methods of providing a specimen for microscopic examination have involved substantial time and services of a technician.
  • the procedure includes the provision of a quantity of liquid specimen in a tube, typically 10 ml, sealing the tube and centrifuging, typically at relatively high speed, such as 2500 rpm, tube is then unsealed and most of the liquid is poured from the tube, leaving a desired specimen about 1 ml which contains sediment disposed in the lower portion of the tube by the centrifuging.
  • the technician then draws a small sample, as by an eyedropper, and deposits the same on a slide for viewing under a microscope.
  • the procedure is subject to human error and requires substantial time and service of the technician.
  • the present invention provides a tube apparatus which simplifies the procedure of providing a specimen for examination.
  • the tube has therein a separator having its upper portion sealingly engaged in the lower portion of the tube, and has a tapered portion and a reduced lower portion which has therein a passage. Centrifuging forces sediment and liquid through the passage in the separator into a lower portion of the tube. The liquid in the lower portion of the tube cannot rise above the separator passage end portion, and an air pocket is therefore created between the separator and the tube wall.
  • the level of liquid in the lower portion of the tube is at the end of the separator outlet passage, and this level provides a predetermined quantity of specimen, typically 1 ml of excess specimen is eliminated, and the tube is not unsealed for such purpose.
  • the specimen for _ Q examination is provided simply by squeezing a portion of the tube to deposit a quantity, such as a drop, of specimen onto a holder or slide.
  • the sealed tube is then discarded. Removal of a plug in an outlet nozzle portion of the tube results in no substantial leakage 5 because of the partial vacuum in the sealed tube, and light squeezing of a portion of the tube produces a selected quantity, such as a drop, of specimen to the slide or holder.
  • Figure 1 is an elevational view of a tube apparatus according to the invention showing a 25 separator, pipette and cap thereof;
  • Figure 2 is a sectional view of a tube apparatus of Figure 1 and cap thereof in open position;
  • Figure 3 is a perspective view showing the expression of a drop of specimen into a preferred holder device according to a co-pending application of the present inventor.
  • a tube 10 is provided for liquid specimens for microscopic analysis, such as urine with particles therein.
  • the tube comprises an elongated, generally tapered body portion 12 of circular cross-section, and upper outwardly extending thin rim 14, and a hinge strip extending therefrom and at its end a cap 16 connected therewith.
  • the cap has a rim portion, as shown, and a body portion 18 adapted to fit sealingly within the upper opening of the tube.
  • the interior portion of the cap has a domed portion 20.
  • the tube and the cap are preferably fabricated of a flexible, resilient material for resilient sealing of components relative to each other, and to enable squeezing and compression .
  • the opposite end or bottom portion 22 of the tube is rounded and tapered, and a pipette end portion 24 extends therefrom.
  • An inwardly tapering frusto- conical passage in this end portion is closable by a plug or pin 28 extending axially of a cap 26 which is adapted to seat against the lower end portion of the tube, as shown.
  • a fluid-tight closure is provided by thus engaging the plug 28 in the passage of the pipette portion 24, thus to provide a closed system for elimination of the chance of contamination.
  • a funnel-shaped separator 30 is positioned in the lower portion of the tube. It is inserted by being urged downwardly, as by an appropriate instrument through the tapered body 12 of the tube into a position, such as that shown, wherein it is sealingly engaged by force-fit in the inner wall of the tube. Separator 30 has a small passage 32 in a reduced cylindrical end portion 34.
  • the quantity of liquid with particles therein, to be examined typically 10 mm of urine or other body fluid is poured into the tube to a predetermined level within 1/4" to 1-1/2" the upper end of the tube.
  • the tube is closed and sealed with the cap 16 in sealing engagement with bead 14 which extends about the upper edge of the tube, as shown, and with the bottom end of the tube sealed by insertion of plug or pin 28 in pipette portion 24.
  • the tube is then centrifuged, in conventional manner, its lower portion disposed radially outwardly, at typically 2400 rpm for about 5 minutes. Centrifuging causes urine and particles therein (blood cells, particles, skin cells, drug components, etc.) to pass via the separator 30 and the reduced passage 32 therein, into lower portion 22 of the tube.
  • the lower portion of the tube is filled by the centrifuging to a level 35 at the lower end of separator passage 34 ( Figure 2).
  • the level cannot rise higher because of the air pocket defined about the separator within the tube, which cannot be displaced. Centrifuging forces sediment and particles to the bottom portion of the tube, while the air pocket at 37 is maintained.
  • the air pocket defines a predetermined specimen quantity, typically 1 ml below the exit passage of separator 30.
  • specimen liquid such as urine with particles therein
  • a pre-determined level such as 10 ml
  • liquid does not pass through separator opening 32 because of its small size, and only a few drops may typically pass therethrough.
  • the level of liquid in the tube cannot rise higher than the level indicated at 35, because of the air pocket.
  • the air pocket 37 is maintained even though sediment fills it to the bottom of the funnel. Sediment may continue to pass down through passage 32 of the separator.
  • Centrifuging causes liquid, and sediment therein, to pass via the separator passage to the level of the lower end of the separator passage, and is prevented from rising above this level by air pocket 37.
  • the air pocket is created by the passage of liquid through the passage 24 in the separator, to a level at which it causes pressure in the area to create the air pocket.
  • the air pocket 37 is automatically maintained, and sediment continues to pass via the separator and displaces urine which moves upwardly via the passage 32 of the separator.
  • the heavier sediment first fills the bottom of the tube, displacing urine, and the liquid, being lighter, passes upwardly through the separator passage.
  • specimen sediment is automatically mixed by action of the separator and the air pocket it provides.
  • the tube is sealed and is not re-opened and urine is not spattered about upon removing a stopper from a pipette portion .
  • a technician simply taps or shakes the tube before squeezing a portion of the tube to permit a specimen drop from the pipette passage.
  • Urine and sediment particles are in correct proportion for examination, with a technician considering the relative concentration between the specimen provided, and the overall tube contents.
  • a technician simply removes the plug from the pipette passage, and squeezes the tube to provide an appropriate specimen. Plug 28 in the pipette passage prevents blockage of the passage by sediment passing therethrough.
  • Removal of the plug from the pipette passage effects sufficient pressure reduction in the tube for partial vacuum to substantially reduce any leakage via the pipette passage.
  • Pressure on the tube to expel a specimen, such as a drop, outwardly from the pipette passage, may be effected by manual compression of a portion of the tube or by exertion of pressure on known portion 20 of the cap.
  • the specimen or drop may be positioned where desired on the slide or holder for microscopic examination.

Abstract

A tube apparatus for providing a specimen for microscopic examination has a separator (30) in a tube (10) to provide upon centrifuging an air pocket (37) at the normal outlet passage (34) of the separator, thus to define a specimen of predetermined size by automatic operation.

Description

Description CENTRIFUGE TUBE APPARATUS
Technical Field
Prior art methods of providing a specimen for microscopic examination have involved substantial time and services of a technician. The procedure includes the provision of a quantity of liquid specimen in a tube, typically 10 ml, sealing the tube and centrifuging, typically at relatively high speed, such as 2500 rpm, tube is then unsealed and most of the liquid is poured from the tube, leaving a desired specimen about 1 ml which contains sediment disposed in the lower portion of the tube by the centrifuging. The technician then draws a small sample, as by an eyedropper, and deposits the same on a slide for viewing under a microscope. The procedure is subject to human error and requires substantial time and service of the technician. The present invention provides a tube apparatus which simplifies the procedure of providing a specimen for examination. The tube has therein a separator having its upper portion sealingly engaged in the lower portion of the tube, and has a tapered portion and a reduced lower portion which has therein a passage. Centrifuging forces sediment and liquid through the passage in the separator into a lower portion of the tube. The liquid in the lower portion of the tube cannot rise above the separator passage end portion, and an air pocket is therefore created between the separator and the tube wall. The level of liquid in the lower portion of the tube is at the end of the separator outlet passage, and this level provides a predetermined quantity of specimen, typically 1 ml of excess specimen is eliminated, and the tube is not unsealed for such purpose. The specimen for _ Q examination is provided simply by squeezing a portion of the tube to deposit a quantity, such as a drop, of specimen onto a holder or slide. The sealed tube is then discarded. Removal of a plug in an outlet nozzle portion of the tube results in no substantial leakage 5 because of the partial vacuum in the sealed tube, and light squeezing of a portion of the tube produces a selected quantity, such as a drop, of specimen to the slide or holder.
The time and services of a technician are greatly
20 reduced, and the probability of human error is substantially reduced.
Brief Description of Drawings
Figure 1 is an elevational view of a tube apparatus according to the invention showing a 25 separator, pipette and cap thereof;
Figure 2 is a sectional view of a tube apparatus of Figure 1 and cap thereof in open position; and
Figure 3 is a perspective view showing the expression of a drop of specimen into a preferred holder device according to a co-pending application of the present inventor.
Best Mode For Carrying Out the Invention
Referring to the drawings, a tube 10 is provided for liquid specimens for microscopic analysis, such as urine with particles therein. The tube comprises an elongated, generally tapered body portion 12 of circular cross-section, and upper outwardly extending thin rim 14, and a hinge strip extending therefrom and at its end a cap 16 connected therewith. The cap has a rim portion, as shown, and a body portion 18 adapted to fit sealingly within the upper opening of the tube. The interior portion of the cap has a domed portion 20. The tube and the cap are preferably fabricated of a flexible, resilient material for resilient sealing of components relative to each other, and to enable squeezing and compression .
The opposite end or bottom portion 22 of the tube is rounded and tapered, and a pipette end portion 24 extends therefrom. An inwardly tapering frusto- conical passage in this end portion is closable by a plug or pin 28 extending axially of a cap 26 which is adapted to seat against the lower end portion of the tube, as shown. A fluid-tight closure is provided by thus engaging the plug 28 in the passage of the pipette portion 24, thus to provide a closed system for elimination of the chance of contamination.
A funnel-shaped separator 30 is positioned in the lower portion of the tube. It is inserted by being urged downwardly, as by an appropriate instrument through the tapered body 12 of the tube into a position, such as that shown, wherein it is sealingly engaged by force-fit in the inner wall of the tube. Separator 30 has a small passage 32 in a reduced cylindrical end portion 34.
In accordance with the invention, the quantity of liquid with particles therein, to be examined, typically 10 mm of urine or other body fluid is poured into the tube to a predetermined level within 1/4" to 1-1/2" the upper end of the tube. The tube is closed and sealed with the cap 16 in sealing engagement with bead 14 which extends about the upper edge of the tube, as shown, and with the bottom end of the tube sealed by insertion of plug or pin 28 in pipette portion 24.
The tube is then centrifuged, in conventional manner, its lower portion disposed radially outwardly, at typically 2400 rpm for about 5 minutes. Centrifuging causes urine and particles therein (blood cells, particles, skin cells, drug components, etc.) to pass via the separator 30 and the reduced passage 32 therein, into lower portion 22 of the tube. The lower portion of the tube is filled by the centrifuging to a level 35 at the lower end of separator passage 34 (Figure 2). The level cannot rise higher because of the air pocket defined about the separator within the tube, which cannot be displaced. Centrifuging forces sediment and particles to the bottom portion of the tube, while the air pocket at 37 is maintained.
The air pocket defines a predetermined specimen quantity, typically 1 ml below the exit passage of separator 30. With the tube filled with specimen liquid, such as urine with particles therein, to a pre-determined level, such as 10 ml, liquid does not pass through separator opening 32 because of its small size, and only a few drops may typically pass therethrough. Regarding the air pocket, the level of liquid in the tube cannot rise higher than the level indicated at 35, because of the air pocket. The air pocket 37 is maintained even though sediment fills it to the bottom of the funnel. Sediment may continue to pass down through passage 32 of the separator.
Centrifuging causes liquid, and sediment therein, to pass via the separator passage to the level of the lower end of the separator passage, and is prevented from rising above this level by air pocket 37.
In accordance with earlier description, it will be understood that the air pocket is created by the passage of liquid through the passage 24 in the separator, to a level at which it causes pressure in the area to create the air pocket.
After centrifuging, the air pocket 37 is automatically maintained, and sediment continues to pass via the separator and displaces urine which moves upwardly via the passage 32 of the separator. The heavier sediment first fills the bottom of the tube, displacing urine, and the liquid, being lighter, passes upwardly through the separator passage. With the invention, specimen sediment is automatically mixed by action of the separator and the air pocket it provides.
With the invention, it is not necessary to pour off liquid from the tube. With the invention, the tube is sealed and is not re-opened and urine is not spattered about upon removing a stopper from a pipette portion .
A technician simply taps or shakes the tube before squeezing a portion of the tube to permit a specimen drop from the pipette passage. Urine and sediment particles are in correct proportion for examination, with a technician considering the relative concentration between the specimen provided, and the overall tube contents. A technician simply removes the plug from the pipette passage, and squeezes the tube to provide an appropriate specimen. Plug 28 in the pipette passage prevents blockage of the passage by sediment passing therethrough.
Removal of the plug from the pipette passage effects sufficient pressure reduction in the tube for partial vacuum to substantially reduce any leakage via the pipette passage.
Pressure on the tube to expel a specimen, such as a drop, outwardly from the pipette passage, may be effected by manual compression of a portion of the tube or by exertion of pressure on known portion 20 of the cap.
The specimen or drop may be positioned where desired on the slide or holder for microscopic examination. In contrast, in the prior art, it is the customary practice to depend upon capillary action to position or dispose a specimen on a slide.
It is not necessary to pour any excess specimen from the tube, as is done in the prior art, requiring opening of the tube, pouring or siphoning off tube contents to leave only about 1 ml at the tube bottom. Typically the specimen and sediment are then mixed, and an eyedropper or the like is utilized to remove a desired sample, which cannot simply be poured out from the tube, only one drop being required. In contrast, with the present invention, the specimen in the tube is sealed and it is not necessary to unseal it. The closed tube can simply be discarded.
It will be understood that various changes and modifications may be made from the preferred embodiments discussed above without departing from the scope of the present invention, which is established by the following claims and equivalents thereof.

Claims

Claims
1. A tube assembly for specimen analysis, comprisin : a tube having a pipette portion extending from a lower end portion thereof, said pipette portion having a passage therethrough, a plug for sealing engagement in said pipette passage, a cap for sealingly closing an upper open end portion of the tube, and a separator having an upper portion sealingly engaged in the tube, said tube having a reduced lower portion defining a passage, whereby upon the filling of the tube to a pre-determined level and the centrifuging thereof, centrifuged liquid passes through said separator passage to provide a specimen of predetermined volume below the separator for expressing thereof upon removal of said plug.
2. A tube assembly according to Claim 1, wherein: said separator has a funnel configuration and said air pocket is defined between the tube and the separator to the level of an outlet portion of an outlet of the reduced lower portion passage of the separator.
3. A tube assembly according to Claim 1, wherein a predetermined volume of specimen is defined below said outlet passage of the separator.
4. A tube assembly according to Claim 3, wherein a predetermined volume of specimen comprises 0.1 ml,
5. A tube assembly according to Claim 1, wherein said separator is sealingly engaged by force- fitting in a tapered portion of the tube.
6. A tube assembly according to Claim 1, wherein: specimen liquid and sediment is automatically mixed during centrifuging by operation of the separator and the air pocket created thereby.
7. A tube assembly according to Claim 1, wherein said tube is tapered to narrow toward its lower portion and said separator is force-fitted in a lower portion of the tube.
8. A tube assembly according to Claim 1, wherein a bead is disposed about an upper open end of the tube for sealing engagement with said cap.
9. A tube assembly according to Claim 1, wherein said pipette passage is tapered inwardly toward its opening.
10. A tube assembly according to Claim 1, wherein said plug is disposed in a cup adapted to engage a lower portion of the tube when the plug is inserted in said pipette passage.
11. A tube assembly according to Claim 1, wherein: upon removal of said plug from the pipette passage, a limited lowering of pressure within the tube tends to retain liquid from dropping through the pipette passage.
12. A tube assembly for specimen analysis, comprisin : a tube having a pipette portion extending from a lower end portion thereof, said pipette portion having a passage therethrough, a plug for sealing engagement in said pipette passage, a cap for sealingly closing an upper open o end portion of the tube, and a separator having an upper portion sealingly engaged in the tube,. said separator having a reduced lower portion which cooperates with the tube to define an air pocket therebetween, said tube having a reduced lower portion defining a passage, whereby upon the filling of the tube to a pre-determined level and the centrifuging thereof, centrifuged liquid passes through said separator passage to provide a specimen of pre-determined volume below the separator for expressing thereof upon removal of said plug.
13. A tube assembly according to Claim 12, wherein said pre-determined volume of specimen comprises 0.1 ml.
14. A tube assembly according to Claim 12, wherein: specimen liquid and sediment is automatically mixed during centrifuging by operation of the separator and the air pocket created thereby.
15. A tube assembly according to Claim 12, wherein said tube is tapered to narrow toward its lower portion and said separator is force-fitted in a lower portion of the tube.
16. A tube assembly according to Claim 12, wherein a bead is disposed about an upper open end of the tube for sealing engagement with said cap.
17. A tube assembly according to Claim 12, wherein said plug is disposed in a cup adapted to engage a lower portion of the tube when the plug is inserted in said pipette passage.
18. A tube assembly according to Claim 12, wherein: upon removal of said plug from the pipette passage, a limited lowering of pressure within the tube tends to retain liquid from dropping through the pipette passage.
PCT/US2000/040728 1999-08-25 2000-08-24 Centrifuge tube apparatus WO2001014850A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU80332/00A AU8033200A (en) 1999-08-25 2000-08-24 Centrifuge tube apparatus

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US15070899P 1999-08-25 1999-08-25
US60/150,708 1999-08-25
US54565500A 2000-04-10 2000-04-10
US09/545,655 2000-04-10

Publications (1)

Publication Number Publication Date
WO2001014850A1 true WO2001014850A1 (en) 2001-03-01

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WO (1) WO2001014850A1 (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006123949A2 (en) * 2005-05-16 2006-11-23 Lab-Tek International Limited Sample holder
US8394342B2 (en) 2008-07-21 2013-03-12 Becton, Dickinson And Company Density phase separation device
US8747781B2 (en) 2008-07-21 2014-06-10 Becton, Dickinson And Company Density phase separation device
US8794452B2 (en) 2009-05-15 2014-08-05 Becton, Dickinson And Company Density phase separation device
US9333445B2 (en) 2008-07-21 2016-05-10 Becton, Dickinson And Company Density phase separation device
CN105865849A (en) * 2016-05-17 2016-08-17 深圳市诺飞特医疗仪器有限公司 Liquid taking and transferring device
US9682373B2 (en) 1999-12-03 2017-06-20 Becton, Dickinson And Company Device for separating components of a fluid sample
US9694359B2 (en) 2014-11-13 2017-07-04 Becton, Dickinson And Company Mechanical separator for a biological fluid
CN110220742A (en) * 2019-06-28 2019-09-10 苏州中车建设工程有限公司 Outdoor depth-setting rapid water taking method
CN110220743A (en) * 2019-06-28 2019-09-10 苏州中车建设工程有限公司 Portable water taking device

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Cited By (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9682373B2 (en) 1999-12-03 2017-06-20 Becton, Dickinson And Company Device for separating components of a fluid sample
WO2006123949A3 (en) * 2005-05-16 2006-12-21 Lab Tek Internat Ltd Sample holder
WO2006123949A2 (en) * 2005-05-16 2006-11-23 Lab-Tek International Limited Sample holder
US8394342B2 (en) 2008-07-21 2013-03-12 Becton, Dickinson And Company Density phase separation device
US8747781B2 (en) 2008-07-21 2014-06-10 Becton, Dickinson And Company Density phase separation device
US10350591B2 (en) 2008-07-21 2019-07-16 Becton, Dickinson And Company Density phase separation device
US9933344B2 (en) 2008-07-21 2018-04-03 Becton, Dickinson And Company Density phase separation device
US9333445B2 (en) 2008-07-21 2016-05-10 Becton, Dickinson And Company Density phase separation device
US9339741B2 (en) 2008-07-21 2016-05-17 Becton, Dickinson And Company Density phase separation device
US9714890B2 (en) 2008-07-21 2017-07-25 Becton, Dickinson And Company Density phase separation device
US9700886B2 (en) 2008-07-21 2017-07-11 Becton, Dickinson And Company Density phase separation device
US9452427B2 (en) 2008-07-21 2016-09-27 Becton, Dickinson And Company Density phase separation device
US9731290B2 (en) 2009-05-15 2017-08-15 Becton, Dickinson And Company Density phase separation device
US8794452B2 (en) 2009-05-15 2014-08-05 Becton, Dickinson And Company Density phase separation device
US11786895B2 (en) 2009-05-15 2023-10-17 Becton, Dickinson And Company Density phase separation device
US9364828B2 (en) 2009-05-15 2016-06-14 Becton, Dickinson And Company Density phase separation device
US9079123B2 (en) 2009-05-15 2015-07-14 Becton, Dickinson And Company Density phase separation device
US9802189B2 (en) 2009-05-15 2017-10-31 Becton, Dickinson And Company Density phase separation device
US9919309B2 (en) 2009-05-15 2018-03-20 Becton, Dickinson And Company Density phase separation device
US9919307B2 (en) 2009-05-15 2018-03-20 Becton, Dickinson And Company Density phase separation device
US9919308B2 (en) 2009-05-15 2018-03-20 Becton, Dickinson And Company Density phase separation device
US8998000B2 (en) 2009-05-15 2015-04-07 Becton, Dickinson And Company Density phase separation device
US10343157B2 (en) 2009-05-15 2019-07-09 Becton, Dickinson And Company Density phase separation device
US11351535B2 (en) 2009-05-15 2022-06-07 Becton, Dickinson And Company Density phase separation device
US10376879B2 (en) 2009-05-15 2019-08-13 Becton, Dickinson And Company Density phase separation device
US10807088B2 (en) 2009-05-15 2020-10-20 Becton, Dickinson And Company Density phase separation device
US10456782B2 (en) 2009-05-15 2019-10-29 Becton, Dickinson And Company Density phase separation device
US10413898B2 (en) 2009-05-15 2019-09-17 Becton, Dickinson And Company Density phase separation device
US9694359B2 (en) 2014-11-13 2017-07-04 Becton, Dickinson And Company Mechanical separator for a biological fluid
CN105865849A (en) * 2016-05-17 2016-08-17 深圳市诺飞特医疗仪器有限公司 Liquid taking and transferring device
CN110220743A (en) * 2019-06-28 2019-09-10 苏州中车建设工程有限公司 Portable water taking device
CN110220742A (en) * 2019-06-28 2019-09-10 苏州中车建设工程有限公司 Outdoor depth-setting rapid water taking method
CN110220742B (en) * 2019-06-28 2021-06-15 苏州中车建设工程有限公司 Outdoor depth-setting rapid water taking method
CN110220743B (en) * 2019-06-28 2021-06-15 苏州中车建设工程有限公司 Portable water taking device

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