WO2001018232A3 - Drug target isogenes: polymorphisms in the uncoupling protein 3 (mitochondrial, proton carrier) gene - Google Patents

Drug target isogenes: polymorphisms in the uncoupling protein 3 (mitochondrial, proton carrier) gene Download PDF

Info

Publication number
WO2001018232A3
WO2001018232A3 PCT/US2000/024784 US0024784W WO0118232A3 WO 2001018232 A3 WO2001018232 A3 WO 2001018232A3 US 0024784 W US0024784 W US 0024784W WO 0118232 A3 WO0118232 A3 WO 0118232A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene
polymorphisms
mitochondrial
uncoupling protein
drug target
Prior art date
Application number
PCT/US2000/024784
Other languages
French (fr)
Other versions
WO2001018232A2 (en
Inventor
Anne Chew
Julie Y Choi
R Rex Denton
Krishnan Nandabalan
Original Assignee
Genaissance Pharmaceuticals
Stephens Joel Claiborne
Anne Chew
Julie Y Choi
R Rex Denton
Krishnan Nandabalan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals, Stephens Joel Claiborne, Anne Chew, Julie Y Choi, R Rex Denton, Krishnan Nandabalan filed Critical Genaissance Pharmaceuticals
Priority to AU2000273645A priority Critical patent/AU2000273645A1/en
Publication of WO2001018232A2 publication Critical patent/WO2001018232A2/en
Publication of WO2001018232A3 publication Critical patent/WO2001018232A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/40—Population genetics; Linkage disequilibrium
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Abstract

Polynucleotides comprising one or more of 19 novel single nucleotide polymorphisms in the human Uncoupling Protein 3 (mitochondrial, proton carrier) (UCP3) gene are described. Compositions and methods for detecting one or more of these polymorphisms are also disclosed. In addition, various genotypes and haplotypes for UCP3 gene that exist in the population are described.
PCT/US2000/024784 1999-09-08 2000-09-08 Drug target isogenes: polymorphisms in the uncoupling protein 3 (mitochondrial, proton carrier) gene WO2001018232A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2000273645A AU2000273645A1 (en) 1999-09-08 2000-09-08 Drug target isogenes: polymorphisms in the uncoupling protein 3 (mitochondrial, proton carrier) gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15278999P 1999-09-08 1999-09-08
US60/152,789 1999-09-08

Publications (2)

Publication Number Publication Date
WO2001018232A2 WO2001018232A2 (en) 2001-03-15
WO2001018232A3 true WO2001018232A3 (en) 2001-09-27

Family

ID=22544451

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/024784 WO2001018232A2 (en) 1999-09-08 2000-09-08 Drug target isogenes: polymorphisms in the uncoupling protein 3 (mitochondrial, proton carrier) gene

Country Status (2)

Country Link
AU (1) AU2000273645A1 (en)
WO (1) WO2001018232A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104131096B (en) * 2014-07-28 2016-08-17 福建农林大学 A kind of method detecting beef cattle UCP3 gene mononucleotide polymorphism

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999048905A1 (en) * 1998-03-23 1999-09-30 Musc Foundation For Research Development Methods for identifying a risk to ucp2 and ucp3 gene variant-related afflictions and compositions thereof
US5974164A (en) * 1994-10-21 1999-10-26 Affymetrix, Inc. Computer-aided visualization and analysis system for sequence evaluation
US5972614A (en) * 1995-12-06 1999-10-26 Genaissance Pharmaceuticals Genome anthologies for harvesting gene variants

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5974164A (en) * 1994-10-21 1999-10-26 Affymetrix, Inc. Computer-aided visualization and analysis system for sequence evaluation
US5972614A (en) * 1995-12-06 1999-10-26 Genaissance Pharmaceuticals Genome anthologies for harvesting gene variants
WO1999048905A1 (en) * 1998-03-23 1999-09-30 Musc Foundation For Research Development Methods for identifying a risk to ucp2 and ucp3 gene variant-related afflictions and compositions thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CAMERON E.R.: "Recent advances in transgenic technology", MOLECULAR BIOTECHNOLOGY, vol. 7, 1997, pages 253 - 265, XP002938360 *
OTABE S. ET AL.: "Mutation screening and association studies of the human uncoupling protein 3 gene in normoglycemic and diabetic morbidly obese patients", DIABETES, vol. 48, January 1999 (1999-01-01), pages 206 - 208, XP002938361 *

Also Published As

Publication number Publication date
AU2000273645A1 (en) 2001-04-10
WO2001018232A2 (en) 2001-03-15

Similar Documents

Publication Publication Date Title
WO2000063441A3 (en) Single nucleotide polymorphisms in mitochondrial genes that segregate with alzheimer's disease
WO2001023410A3 (en) Drug target isogenes: polymorphisms in the interleukin 13 gene
WO1998033937A3 (en) GENOMIC SEQUENCE OF THE HUMAN ν-OPIOID RECEPTOR GENE AND THE VARIANTS, POLYMORPHISMS AND MUTATIONS THEREOF
WO2001018232A3 (en) Drug target isogenes: polymorphisms in the uncoupling protein 3 (mitochondrial, proton carrier) gene
WO2001027312A3 (en) Drug target isogenes: polymorphisms in the m1 muscarinic acetylcholine receptor gene
WO2001011010A3 (en) Drug target isogenes: polymorphisms in the immunoglobulin e receptor i alpha subunit gene
WO2001079229A3 (en) Haplotypes of the cxcr4 gene
WO2001029176A3 (en) Drug target isogenes: polymorphisms in the cholinergic receptor, muscarinic 3 gene
WO2001025245A3 (en) Drug target isogenes: polymorphisms in the death-associated protein 6 gene
WO2001025194A3 (en) Drug target isogenes: polymorphisms in the 5-hydroxytryptamine (serotonin) receptor 1b gene
WO2001027311A3 (en) Drug target isogenes: polymorphisms in the 5-hydroxytryptamine (serotonin) receptor 1d gene
WO2001027313A3 (en) Drug target isogenes: polymorphisms in the cholinergic receptor, muscarinic 2 gene
WO2001058914A3 (en) Haplotypes of the interleukin 15 gene
WO2001079230A3 (en) Haplotypes of the ugt1a1 gene
WO2001077363A3 (en) Haplotypes of the impdh2 gene
AU2001213316A8 (en) Drug target isogenes: polymorphisms in the 5-hydroxytryptamine (serotonin) receptor 1d gene
WO2001079240A3 (en) Haplotypes of the rangap1 gene
WO2001077131A3 (en) Haplotypes of the bglap gene
WO2001092278A3 (en) Haplotypes of the rlbp1 gene
WO2001074833A3 (en) Haplotypes of the chrnb2 gene
WO2001072965A3 (en) Haplotypes of the fkbp8 gene
AU6612700A (en) Drug target isogenes: polymorphisms in the solute carrier family 6 neurotransmitter transporter, serotonin , member gene
WO2001072966A3 (en) Haplotypes of the pltp gene
WO2001075063A3 (en) Haplotypes of the chrnb3 gene
WO2001079238A3 (en) Haplotypes of the mmp3 gene

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP