WO2001022956A3 - NEUE KOMBINATION VON LOTEPREDNOL UND β2-ADRENOZEPTOR-AGONISTEN - Google Patents

NEUE KOMBINATION VON LOTEPREDNOL UND β2-ADRENOZEPTOR-AGONISTEN Download PDF

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Publication number
WO2001022956A3
WO2001022956A3 PCT/EP2000/009392 EP0009392W WO0122956A3 WO 2001022956 A3 WO2001022956 A3 WO 2001022956A3 EP 0009392 W EP0009392 W EP 0009392W WO 0122956 A3 WO0122956 A3 WO 0122956A3
Authority
WO
WIPO (PCT)
Prior art keywords
novel combination
loteprednol
adrenoceptor agonists
medicaments
combination
Prior art date
Application number
PCT/EP2000/009392
Other languages
English (en)
French (fr)
Other versions
WO2001022956A2 (de
Inventor
Istvan Szelenyi
Hildegard Poppe
Sabine Heer
Juergen Engel
Original Assignee
Asta Medica Ag
Istvan Szelenyi
Hildegard Poppe
Sabine Heer
Juergen Engel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP00969304A priority Critical patent/EP1216047B1/de
Priority to DE50011340T priority patent/DE50011340D1/de
Application filed by Asta Medica Ag, Istvan Szelenyi, Hildegard Poppe, Sabine Heer, Juergen Engel filed Critical Asta Medica Ag
Priority to SI200030769T priority patent/SI1216047T1/sl
Priority to EEP200200163A priority patent/EE05050B1/xx
Priority to AT00969304T priority patent/ATE306271T1/de
Priority to CA002389111A priority patent/CA2389111C/en
Priority to AU79074/00A priority patent/AU7907400A/en
Priority to HU0202753A priority patent/HUP0202753A3/hu
Priority to PL353487A priority patent/PL196729B1/pl
Priority to US10/089,449 priority patent/US7521438B1/en
Priority to MXPA02003329A priority patent/MXPA02003329A/es
Priority to JP2001526168A priority patent/JP5068912B2/ja
Priority to BRPI0014374-0A priority patent/BR0014374B1/pt
Publication of WO2001022956A2 publication Critical patent/WO2001022956A2/de
Publication of WO2001022956A3 publication Critical patent/WO2001022956A3/de
Priority to CY20051101559T priority patent/CY1105548T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Abstract

Die Erfindung betrifft eine neue Kombination von einem Soft-Steroid, insbesondere oteprednol, und mindestens einem β2-Adrenozeptor-Agonisten zur simultanen, sequentiellen oder separaten Behandlung von Allergien und/oder Atemwegserkrankungen, die Kombination enthaltende Arzneimittel, Verfahren zur Herstellung solcher Arzneimittel und die Verwendung der neuen Kombination zur Herstellung von Arzneimitteln zur simultanen, sequentiellen oder separaten Behandlung von Allergien und/oder Atemwegserkrankungen.
PCT/EP2000/009392 1999-09-30 2000-09-26 NEUE KOMBINATION VON LOTEPREDNOL UND β2-ADRENOZEPTOR-AGONISTEN WO2001022956A2 (de)

Priority Applications (14)

Application Number Priority Date Filing Date Title
PL353487A PL196729B1 (pl) 1999-09-30 2000-09-26 Kompozycja farmaceutyczna zawierająca loteprednol i agonistę receptora ß2 adrenergicznego, lek do leczenia astmy oskrzelowej, sposób produkcji leku i jego zastosowanie
HU0202753A HUP0202753A3 (en) 1999-09-30 2000-09-26 Pharmaceutical compositions containing novel combination of loteprednol and b2-adrenoceptor agonists and their use
SI200030769T SI1216047T1 (sl) 1999-09-30 2000-09-26 Kombinacija loteprednola in agonistov beta2-adrenoceptorja in njena uporaba za zdravljenje bronhialne astme
DE50011340T DE50011340D1 (de) 1999-09-30 2000-09-26 Kombination von loteprednol und beta2-adrenozeptor-agonisten und ihre verwendung durch inhalation zur behandlung von asthma bronchiale
AT00969304T ATE306271T1 (de) 1999-09-30 2000-09-26 Kombination von loteprednol und beta2- adrenozeptor-agonisten und ihre verwendung durch inhalation zur behandlung von asthma bronchiale
CA002389111A CA2389111C (en) 1999-09-30 2000-09-26 Novel combination of loteprednol and .beta.2-adrenoceptor agonists
US10/089,449 US7521438B1 (en) 1999-09-30 2000-09-26 Combination of loteprednol and β2-adrenoceptor agonists
EP00969304A EP1216047B1 (de) 1999-09-30 2000-09-26 Kombination von loteprednol und beta2-adrenozeptor-agonisten und ihre verwendung durch inhalation zur behandlung von asthma bronchiale
EEP200200163A EE05050B1 (et) 1999-09-30 2000-09-26 Loteprednooli ja β2-adrenoretseptori agonistide kombinatsioon, selle kasutamine, seda kombinatsiooni sisaldav farmatseutiline preparaat ja ravim ning meetod seda kombinatsiooni sisaldava ravimivalmistamiseks
AU79074/00A AU7907400A (en) 1999-09-30 2000-09-26 Novel combination of loteprednol and beta2-adrenoceptor agonists
MXPA02003329A MXPA02003329A (es) 1999-09-30 2000-09-26 Combinacion novedosa de beta2 y agonistas del receptor adrenal.
JP2001526168A JP5068912B2 (ja) 1999-09-30 2000-09-26 ロテプレドノールとβ２アドレナリン受容体アゴニストの新規組み合わせ
BRPI0014374-0A BR0014374B1 (pt) 1999-09-30 2000-09-26 preparaÇço farmacÊutica, medicamento, processo para produÇço de dito medicamento e uso de uma combinaÇço de loteprednol e agonistas do adrenorreceptor beta dois.
CY20051101559T CY1105548T1 (el) 1999-09-30 2005-12-15 Συνδυασμος του loteprednol και αγωνιστων του β2-αδρενοϋποδοχεως και η χρηση του με εισπνοες για την αγωγη του βρογχικου ασθματος

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19947235.1 1999-09-30
DE19947235A DE19947235A1 (de) 1999-09-30 1999-09-30 Neue Kombination von Loteprednol und beta¶2¶-Adrenorezeptor-Agonisten

Publications (2)

Publication Number Publication Date
WO2001022956A2 WO2001022956A2 (de) 2001-04-05
WO2001022956A3 true WO2001022956A3 (de) 2001-10-11

Family

ID=7924101

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/009392 WO2001022956A2 (de) 1999-09-30 2000-09-26 NEUE KOMBINATION VON LOTEPREDNOL UND β2-ADRENOZEPTOR-AGONISTEN

Country Status (20)

Country Link
US (1) US7521438B1 (de)
EP (1) EP1216047B1 (de)
JP (1) JP5068912B2 (de)
AR (1) AR025924A1 (de)
AT (1) ATE306271T1 (de)
AU (1) AU7907400A (de)
BR (1) BR0014374B1 (de)
CA (1) CA2389111C (de)
CY (1) CY1105548T1 (de)
CZ (1) CZ296396B6 (de)
DE (2) DE19947235A1 (de)
DK (1) DK1216047T3 (de)
EE (1) EE05050B1 (de)
ES (1) ES2248131T3 (de)
HU (1) HUP0202753A3 (de)
MX (1) MXPA02003329A (de)
PL (1) PL196729B1 (de)
SI (1) SI1216047T1 (de)
TW (1) TWI253930B (de)
WO (1) WO2001022956A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0012260D0 (en) * 2000-05-19 2000-07-12 Astrazeneca Ab Novel composition
US6667344B2 (en) 2001-04-17 2003-12-23 Dey, L.P. Bronchodilating compositions and methods
US20030055026A1 (en) 2001-04-17 2003-03-20 Dey L.P. Formoterol/steroid bronchodilating compositions and methods of use thereof
CN100450488C (zh) * 2003-11-03 2009-01-14 诺顿·希尔思凯尔有限公司 用于干粉吸入剂的软类固醇组合物
EP2221048A1 (de) 2009-02-18 2010-08-25 Siegfried Generics International AG Pharmazeutische Zusammensetzungen zur Inhalation
US9238144B2 (en) * 2013-03-14 2016-01-19 Neuropace, Inc. Optimizing data retrieval from an active implantable medical device
WO2022016150A1 (en) * 2020-07-17 2022-01-20 Ross Peter M Methods for the treatment of cytokine release syndromes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5830490A (en) * 1997-04-04 1998-11-03 Weinstein; Robert E. Method and device for organizing and coordinating the combined use of topical aerosols and oral medications for the treatment of disorders
WO2000028979A1 (de) * 1998-11-13 2000-05-25 Jago Research Ag Trockenpulver zur inhalation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB416950A (en) * 1933-07-28 1934-09-25 Ambrose Heal An improved support member for beds, settees, wardrobes and other articles of furniture
US4710495A (en) 1980-07-10 1987-12-01 Otsuka Pharmaceutical Co., Ltd. Soft steroids having anti-inflammatory activity
ZA814440B (en) * 1980-07-10 1982-10-27 Otsuka Pharma Co Ltd Soft steroids having anti-inflammatory activity
US4996335A (en) 1980-07-10 1991-02-26 Nicholas S. Bodor Soft steroids having anti-inflammatory activity
TW503113B (en) * 1997-01-16 2002-09-21 Senju Pharma Co Aqueous suspension for nasal administration
NZ337065A (en) * 1997-02-05 2001-02-23 Jago Pharma Ag Medical aerosol formulations containing carbon dioxide, a hydrofluoroalkane, a cosolvent and a beta-mimetic / corticoid / anticholinergic / spasmolytic / analgesic agent

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5830490A (en) * 1997-04-04 1998-11-03 Weinstein; Robert E. Method and device for organizing and coordinating the combined use of topical aerosols and oral medications for the treatment of disorders
WO2000028979A1 (de) * 1998-11-13 2000-05-25 Jago Research Ag Trockenpulver zur inhalation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
L.BJERMER, L.LARSSON: "Long-acting beta-2-agonists: how are they used in an optimal way?", RESPIRATORY MEDICINE, vol. 91, no. 10, 1997, pages 587 - 591, XP000992766 *
T. VAN DER MOLEN E.A.: "Effects of the long acting beta agonist formoterol on asthma control in asthmatic patients using inhaled corticosteroids", THORAX, vol. 52, no. 6, 1997, pages 535 - 539, XP000992767 *

Also Published As

Publication number Publication date
ES2248131T3 (es) 2006-03-16
CZ296396B6 (cs) 2006-03-15
JP2003510276A (ja) 2003-03-18
CA2389111A1 (en) 2001-04-05
HUP0202753A2 (hu) 2002-12-28
DK1216047T3 (da) 2006-02-13
US7521438B1 (en) 2009-04-21
PL353487A1 (en) 2003-11-17
JP5068912B2 (ja) 2012-11-07
BR0014374A (pt) 2002-06-25
PL196729B1 (pl) 2008-01-31
BR0014374B1 (pt) 2012-12-25
MXPA02003329A (es) 2004-09-10
EP1216047A2 (de) 2002-06-26
CZ20021095A3 (cs) 2002-08-14
SI1216047T1 (sl) 2006-02-28
EE05050B1 (et) 2008-08-15
CA2389111C (en) 2009-04-14
CY1105548T1 (el) 2010-07-28
DE50011340D1 (de) 2006-02-23
TWI253930B (en) 2006-05-01
DE19947235A1 (de) 2001-04-05
EE200200163A (et) 2003-04-15
HUP0202753A3 (en) 2004-06-28
WO2001022956A2 (de) 2001-04-05
AR025924A1 (es) 2002-12-18
EP1216047B1 (de) 2005-10-12
ATE306271T1 (de) 2005-10-15
AU7907400A (en) 2001-04-30

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