WO2001025421A3 - Materials and method for detecting interaction of cftr polypeptides - Google Patents
Materials and method for detecting interaction of cftr polypeptides Download PDFInfo
- Publication number
- WO2001025421A3 WO2001025421A3 PCT/US2000/027900 US0027900W WO0125421A3 WO 2001025421 A3 WO2001025421 A3 WO 2001025421A3 US 0027900 W US0027900 W US 0027900W WO 0125421 A3 WO0125421 A3 WO 0125421A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- cftr
- subject invention
- materials
- proteins
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4712—Cystic fibrosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/6895—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/20—Detection means characterised by being a gene reporter based analysis
- C12Q2565/201—Two hybrid system
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/089,875 US7238474B1 (en) | 1999-10-06 | 2000-10-06 | Materials and methods for detecting interaction of CFTR polypeptides |
AU11939/01A AU1193901A (en) | 1999-10-06 | 2000-10-06 | Materials and method for detecting interaction of cftr polypeptides |
US11/821,812 US8288107B2 (en) | 1999-10-06 | 2007-06-25 | Materials and methods for detecting interaction of CFTR polypeptides |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15799699P | 1999-10-06 | 1999-10-06 | |
US60/157,996 | 1999-10-06 | ||
US18189200P | 2000-02-11 | 2000-02-11 | |
US60/181,892 | 2000-02-11 | ||
US18237300P | 2000-02-14 | 2000-02-14 | |
US60/182,373 | 2000-02-14 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/089,875 A-371-Of-International US7238474B1 (en) | 1999-10-06 | 2000-10-06 | Materials and methods for detecting interaction of CFTR polypeptides |
US11/821,812 Continuation US8288107B2 (en) | 1999-10-06 | 2007-06-25 | Materials and methods for detecting interaction of CFTR polypeptides |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2001025421A2 WO2001025421A2 (en) | 2001-04-12 |
WO2001025421A3 true WO2001025421A3 (en) | 2001-08-30 |
WO2001025421B1 WO2001025421B1 (en) | 2001-09-27 |
Family
ID=27388112
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/027900 WO2001025421A2 (en) | 1999-10-06 | 2000-10-06 | Materials and method for detecting interaction of cftr polypeptides |
Country Status (3)
Country | Link |
---|---|
US (2) | US7238474B1 (en) |
AU (1) | AU1193901A (en) |
WO (1) | WO2001025421A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014144860A1 (en) * | 2013-03-15 | 2014-09-18 | Vertex Pharmaceuticals Incorporated | Correctors acting through msd1 of cftr protein |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994025607A1 (en) * | 1993-04-23 | 1994-11-10 | University Of Iowa Research Foundation | Method of assaying for drugs which restore function of mutant cftr protein |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5543399A (en) | 1989-08-22 | 1996-08-06 | Hsc Research & Development Limited Partnership | Cystic fibrosis transmembrane conductance regulator (CFTR) protein |
US5283173A (en) * | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
US5674898A (en) | 1990-03-05 | 1997-10-07 | Genzyme Corporation | Methods and therapeutic compositions for treating cystic fibrosis |
US5981714A (en) | 1990-03-05 | 1999-11-09 | Genzyme Corporation | Antibodies specific for cystic fibrosis transmembrane conductance regulator and uses therefor |
US5939536A (en) | 1990-03-05 | 1999-08-17 | Genzyme Corporation | Methods for purifying cystic fibrosis transmembrane conductance regulation |
US7118911B1 (en) | 1990-03-05 | 2006-10-10 | Genzyme Corporation | DNA molecules stabilized for propagation in bacterial cells that encode cystic fibrosis transmembrane conductance regulator |
US5670488A (en) | 1992-12-03 | 1997-09-23 | Genzyme Corporation | Adenovirus vector for gene therapy |
CA2037478A1 (en) | 1990-03-05 | 1991-09-06 | Richard Gregory | Diagnostic and treatment methods involving the cystic fibrosis transmembrane regulator |
CA2250780A1 (en) | 1996-04-10 | 1997-10-16 | The Regents Of The University Of California | Correction of genetic defects using chemical chaperones |
US6270954B1 (en) | 1996-04-10 | 2001-08-07 | The Regents Of The University Of California | Correction of genetic defects using chemical chaperones |
US6316223B1 (en) * | 1998-03-30 | 2001-11-13 | Rigel Pharmaceuticals, Inc. | Mammalian protein interaction cloning system |
-
2000
- 2000-10-06 US US10/089,875 patent/US7238474B1/en not_active Expired - Fee Related
- 2000-10-06 AU AU11939/01A patent/AU1193901A/en not_active Abandoned
- 2000-10-06 WO PCT/US2000/027900 patent/WO2001025421A2/en active Application Filing
-
2007
- 2007-06-25 US US11/821,812 patent/US8288107B2/en not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994025607A1 (en) * | 1993-04-23 | 1994-11-10 | University Of Iowa Research Foundation | Method of assaying for drugs which restore function of mutant cftr protein |
Non-Patent Citations (5)
Title |
---|
ANNEREAU ET AL: "Insight into cystic fibrosis by structural modeling of CFTR first nucleotide binding fold (NBF1)", COMPTES RENDUS DES SEANCES DE L'ACADEMIE DES SCIENCES. SERIE III: SCIENCES DE LA VIE,NL,ELSEVIER, AMSTERDAM, vol. 320, no. 2, 1997, pages 113 - 121, XP002085670, ISSN: 0764-4469 * |
HALLOWS KENNETH R ET AL: "Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase.", JOURNAL OF CLINICAL INVESTIGATION, vol. 105, no. 12, June 2000 (2000-06-01), pages 1711 - 1721, XP002163368, ISSN: 0021-9738 * |
KUNZELMANN K ET AL: "Inhibition of epithelial Na+ currents by intracellular domains of the cystic fibrosis transmembrane conductance regulator.", FEBS LETTERS, vol. 400, no. 3, 1997, pages 341 - 344, XP002163366, ISSN: 0014-5793 * |
NEVILLE DAVID C A ET AL: "Expression and characterization of the NBD1-R domain region of CFTR: Evidence for subunit-subunit interactions.", BIOCHEMISTRY, vol. 37, no. 8, 24 February 1998 (1998-02-24), pages 2401 - 2409, XP002163367, ISSN: 0006-2960 * |
THOREAU V ET AL: "Molecular cloning, expression analysis, and chromosomal localization of human Syntaxin 8 (STX8)", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,ACADEMIC PRESS INC. ORLANDO, FL,US, vol. 257, 1999, pages 577 - 583, XP002102758, ISSN: 0006-291X * |
Also Published As
Publication number | Publication date |
---|---|
WO2001025421B1 (en) | 2001-09-27 |
US7238474B1 (en) | 2007-07-03 |
US8288107B2 (en) | 2012-10-16 |
US20080167259A1 (en) | 2008-07-10 |
AU1193901A (en) | 2001-05-10 |
WO2001025421A2 (en) | 2001-04-12 |
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