WO2001027614A1 - Verfahren und vorrichtung zum messen an in einer flüssigen umgebung befindlichen zellen - Google Patents
Verfahren und vorrichtung zum messen an in einer flüssigen umgebung befindlichen zellen Download PDFInfo
- Publication number
- WO2001027614A1 WO2001027614A1 PCT/EP2000/008895 EP0008895W WO0127614A1 WO 2001027614 A1 WO2001027614 A1 WO 2001027614A1 EP 0008895 W EP0008895 W EP 0008895W WO 0127614 A1 WO0127614 A1 WO 0127614A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- substrate
- cell
- channels
- channel
- electrode
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48728—Investigating individual cells, e.g. by patch clamp, voltage clamp
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU74190/00A AU7419000A (en) | 1999-10-08 | 2000-09-12 | Method and device for taking measurements of cells which are contained in a liquid environment |
JP2001530574A JP2003511699A (ja) | 1999-10-08 | 2000-09-12 | 液体環境内にある細胞の測定を行なう方法および装置 |
DE50013889T DE50013889D1 (de) | 1999-10-08 | 2000-09-12 | Vorrichtung zum messen an in einer flüssigen umgebung befindlichen zellen |
DK00962475T DK1218736T3 (da) | 1999-10-08 | 2000-09-12 | Indretning til måling på celler i flydende omgivelser |
EP00962475A EP1218736B1 (de) | 1999-10-08 | 2000-09-12 | Vorrichtung zum messen an in einer flüssigen umgebung befindlichen zellen |
US10/302,163 US6984297B2 (en) | 1999-10-08 | 2002-11-20 | Device for taking measurements of cells which are contained in a liquid environment |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19948473A DE19948473A1 (de) | 1999-10-08 | 1999-10-08 | Verfahren und Vorrichtung zum Messen an in einer flüssigen Umgebung befindlichen Zellen |
DE19948473.2 | 1999-10-08 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10110258 A-371-Of-International | 2000-09-12 | ||
US10/302,163 Continuation US6984297B2 (en) | 1999-10-08 | 2002-11-20 | Device for taking measurements of cells which are contained in a liquid environment |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2001027614A1 true WO2001027614A1 (de) | 2001-04-19 |
Family
ID=7924921
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2000/008895 WO2001027614A1 (de) | 1999-10-08 | 2000-09-12 | Verfahren und vorrichtung zum messen an in einer flüssigen umgebung befindlichen zellen |
Country Status (10)
Country | Link |
---|---|
US (1) | US6984297B2 (de) |
EP (1) | EP1218736B1 (de) |
JP (1) | JP2003511699A (de) |
AT (1) | ATE349008T1 (de) |
AU (1) | AU7419000A (de) |
DE (2) | DE19948473A1 (de) |
DK (1) | DK1218736T3 (de) |
ES (1) | ES2280241T3 (de) |
PT (1) | PT1218736E (de) |
WO (1) | WO2001027614A1 (de) |
Cited By (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002004943A2 (en) * | 2000-07-07 | 2002-01-17 | Bristol-Myers Squibb Company | Electrophysiology configuration suitable for high throughput screening of compounds for drug discovery |
WO2002029402A3 (en) * | 2000-10-02 | 2002-07-18 | Sophion Bioscience As | System for electrophysiological measurements |
EP1250596A1 (de) * | 1999-12-24 | 2002-10-23 | AstraZeneca AB | Vorrichtung und verfahren zum ausführen von elektrischen messungen an einem gegenstand |
WO2003096002A1 (fr) * | 2002-05-13 | 2003-11-20 | Matsushita Electric Industrial Co., Ltd. | Instrument et procede de mesure du signal d'action d'un echantillon biologique |
WO2003104788A1 (ja) * | 2002-06-05 | 2003-12-18 | 松下電器産業株式会社 | 細胞外電位測定デバイスおよびその製造方法 |
US6682649B1 (en) | 1999-10-01 | 2004-01-27 | Sophion Bioscience A/S | Substrate and a method for determining and/or monitoring electrophysiological properties of ion channels |
US6776896B1 (en) | 2000-10-11 | 2004-08-17 | Axon Instruments, Inc. | Method of positioning cells for electrophysiological testing |
GB2401689A (en) * | 2000-10-11 | 2004-11-17 | Axon Instr Inc | A multi-chamber electrode assembly |
EP1501924A2 (de) * | 2002-05-04 | 2005-02-02 | Aviva Biosciences Corporation | Vorrichtung mit strukturen nachweisendem ionentransport und verwendungsverfahren |
JP2005514718A (ja) * | 2001-07-26 | 2005-05-19 | ハンディラブ・インコーポレーテッド | マイクロフルイディック処理方法及びシステム |
JP2005517180A (ja) * | 2002-02-05 | 2005-06-09 | ザ ユニヴァーシティー コート オブ ザ ユニヴァーシティー オブ グラスゴー | 細胞検定を実施するための装置 |
US6932893B2 (en) | 2000-10-02 | 2005-08-23 | Sophion Bioscience A/S | System for electrophysiological measurements |
EP1283985B1 (de) * | 2000-07-31 | 2006-06-07 | Flyion GmbH | Verfahren und vorrichtung für patch-clamp-messungen an zellen |
US7829025B2 (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices |
US7968305B2 (en) | 2001-03-24 | 2011-06-28 | Aviva Biosciences Corporation | Biochips including ion transport detecting structures and methods of use |
US8043581B2 (en) | 2001-09-12 | 2011-10-25 | Handylab, Inc. | Microfluidic devices having a reduced number of input and output connections |
US8071363B2 (en) | 2006-05-25 | 2011-12-06 | Panasonic Corporation | Chip for cell electrophysiological sensor, cell electrophysiological sensor using the same, and manufacturing method of chip for cell electrophysiological sensor |
US8202439B2 (en) | 2002-06-05 | 2012-06-19 | Panasonic Corporation | Diaphragm and device for measuring cellular potential using the same, manufacturing method of the diaphragm |
US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
US8883490B2 (en) | 2006-03-24 | 2014-11-11 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US8895311B1 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
US9040288B2 (en) | 2006-03-24 | 2015-05-26 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using the same |
US9051604B2 (en) | 2001-02-14 | 2015-06-09 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
US9080207B2 (en) | 2006-03-24 | 2015-07-14 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US9146221B2 (en) | 2001-03-24 | 2015-09-29 | Aviva Biosciences Corporation | High-density ion transport measurement biochip devices and methods |
USD742027S1 (en) | 2011-09-30 | 2015-10-27 | Becton, Dickinson And Company | Single piece reagent holder |
US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US9217143B2 (en) | 2007-07-13 | 2015-12-22 | Handylab, Inc. | Polynucleotide capture materials, and methods of using same |
US9222954B2 (en) | 2011-09-30 | 2015-12-29 | Becton, Dickinson And Company | Unitized reagent strip |
US9238223B2 (en) | 2007-07-13 | 2016-01-19 | Handylab, Inc. | Microfluidic cartridge |
US9259735B2 (en) | 2001-03-28 | 2016-02-16 | Handylab, Inc. | Methods and systems for control of microfluidic devices |
US9259734B2 (en) | 2007-07-13 | 2016-02-16 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US9347586B2 (en) | 2007-07-13 | 2016-05-24 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
USD787087S1 (en) | 2008-07-14 | 2017-05-16 | Handylab, Inc. | Housing |
US9670528B2 (en) | 2003-07-31 | 2017-06-06 | Handylab, Inc. | Processing particle-containing samples |
US9765389B2 (en) | 2011-04-15 | 2017-09-19 | Becton, Dickinson And Company | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
US9815057B2 (en) | 2006-11-14 | 2017-11-14 | Handylab, Inc. | Microfluidic cartridge and method of making same |
US9890955B2 (en) | 2012-08-24 | 2018-02-13 | Ansaldo Energia Switzerland AG | Sequential combustion with dilution gas mixer |
US10179910B2 (en) | 2007-07-13 | 2019-01-15 | Handylab, Inc. | Rack for sample tubes and reagent holders |
US10822644B2 (en) | 2012-02-03 | 2020-11-03 | Becton, Dickinson And Company | External files for distribution of molecular diagnostic tests and determination of compatibility between tests |
US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US11453906B2 (en) | 2011-11-04 | 2022-09-27 | Handylab, Inc. | Multiplexed diagnostic detection apparatus and methods |
US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU9786798A (en) * | 1997-10-10 | 1999-05-03 | Biosepra Inc. | Aligned multiwell multiplate stack and method for processing biological/chemicalsamples using the same |
CA2316966C (en) | 1997-12-17 | 2008-04-08 | Horst Vogel | Positioning and electrophysiological characterization of individual cells and reconstituted membrane systems on microstructured carriers |
US20020144905A1 (en) * | 1997-12-17 | 2002-10-10 | Christian Schmidt | Sample positioning and analysis system |
US7244349B2 (en) * | 1997-12-17 | 2007-07-17 | Molecular Devices Corporation | Multiaperture sample positioning and analysis system |
FR2802078B1 (fr) * | 1999-12-14 | 2003-10-03 | Univ Joseph Fourier | Microelectrode support de cellules a membrane excitable |
EP1278499A2 (de) | 2000-05-05 | 2003-01-29 | Hill-Rom Services, Inc. | Fernbedienung für ein krankenbett |
AU2001261198A1 (en) | 2000-05-05 | 2001-11-20 | Hill-Rom Services, Inc. | Patient point of care computer system |
DE10032568A1 (de) * | 2000-07-05 | 2002-01-24 | Nmi Univ Tuebingen | Vorrichtung und Verfahren zum elektrischen Kontaktieren von in einer Flüssigkeit in Suspension befindlichen biologischen Zellen |
US7067046B2 (en) * | 2000-08-04 | 2006-06-27 | Essen Instruments, Inc. | System for rapid chemical activation in high-throughput electrophysiological measurements |
KR20020086625A (ko) * | 2001-01-09 | 2002-11-18 | 마쯔시다덴기산교 가부시키가이샤 | 세포외 전위 측정용 디바이스, 그것을 사용한 세포외 전위측정 방법 및 그것을 구비한 고속 약품 스크리닝 장치 |
EP1406086A4 (de) * | 2001-06-05 | 2007-10-31 | Matsushita Electric Ind Co Ltd | Signaldetektionssensor mit mehrfachelektrode |
EP1423500A4 (de) * | 2001-08-06 | 2008-07-16 | Univ Vanderbilt | Vorrichtung und verfahren zum nachweis der reaktion mehrerer zellen auf wenigstens einen interessierenden analyten |
DK1460415T3 (da) * | 2001-11-19 | 2011-04-26 | Panasonic Corp | Måleindretning til måling af et elektrisk signal, der afgives af en biologisk prøve |
FR2839979B1 (fr) | 2002-05-21 | 2004-08-20 | Agronomique Inst Nat Rech | Dispositif de culture de cellules |
FR2839980B1 (fr) * | 2002-05-21 | 2004-08-20 | Agronomique Inst Nat Rech | Dispositif de culture de cellules |
JP4552423B2 (ja) * | 2003-11-21 | 2010-09-29 | パナソニック株式会社 | 細胞外電位測定デバイスおよびこれを用いた細胞外電位の測定方法 |
WO2007072790A1 (ja) | 2005-12-20 | 2007-06-28 | Matsushita Electric Industrial Co., Ltd. | 細胞電気生理センサ |
JP4449519B2 (ja) * | 2004-03-22 | 2010-04-14 | パナソニック株式会社 | 細胞外電位測定デバイスおよびその製造方法 |
US8257962B2 (en) | 2003-03-07 | 2012-09-04 | Panasonic Corporation | Extracellular potential measuring device and its manufacturing method |
JP4691407B2 (ja) * | 2005-06-29 | 2011-06-01 | パナソニック株式会社 | 細胞電位測定用容器 |
JP3945338B2 (ja) * | 2002-08-01 | 2007-07-18 | 松下電器産業株式会社 | 細胞外電位測定デバイスおよびその製造方法 |
JP3945317B2 (ja) * | 2002-06-05 | 2007-07-18 | 松下電器産業株式会社 | 細胞外電位測定デバイスおよびその製造方法 |
JP4834335B2 (ja) * | 2005-06-29 | 2011-12-14 | パナソニック株式会社 | 細胞電位測定用容器 |
FR2844052B1 (fr) * | 2002-08-28 | 2005-07-01 | Commissariat Energie Atomique | Dispositif de mesure de l'activite electrique d'elements biologiques et ses applications |
DE10251767A1 (de) * | 2002-11-07 | 2004-05-27 | Forschungszentrum Jülich GmbH | Vorrichtung und Verfahren zur Messung elektrischer Vorgänge an biologischen Membranen |
US7321795B2 (en) * | 2003-03-24 | 2008-01-22 | Les Bogdanowicz | Compositions for electric stimulation of the eye |
WO2005001018A1 (ja) * | 2003-06-27 | 2005-01-06 | Matsushita Electric Industrial Co., Ltd. | 薬理測定装置およびシステム並びにそれに用いるウェル容器 |
US7399205B2 (en) | 2003-08-21 | 2008-07-15 | Hill-Rom Services, Inc. | Plug and receptacle having wired and wireless coupling |
US7319386B2 (en) | 2004-08-02 | 2008-01-15 | Hill-Rom Services, Inc. | Configurable system for alerting caregivers |
EP1783202B1 (de) * | 2004-08-25 | 2013-10-02 | Panasonic Corporation | Sonde zum messen des elektrischen potentials einer zelle |
JP2006184207A (ja) * | 2004-12-28 | 2006-07-13 | Matsushita Electric Ind Co Ltd | 細胞膜の特性および状態の少なくとも一方の電気的測定方法および電気的測定装置 |
EP1767929B1 (de) | 2005-06-07 | 2014-03-05 | Panasonic Corporation | Vorrichtung zum messen der elektrischen physiologie von zellen |
JP4821319B2 (ja) * | 2005-12-28 | 2011-11-24 | パナソニック株式会社 | 細胞電気生理センサアレイおよびその製造方法 |
JP2007218716A (ja) * | 2006-02-16 | 2007-08-30 | Matsushita Electric Ind Co Ltd | 細胞電気生理センサ |
EP2041478B1 (de) * | 2006-03-07 | 2014-08-06 | QD Vision, Inc. | Halbleiternanokristalle enthaltender artikel |
GB2436145A (en) * | 2006-03-16 | 2007-09-19 | Sophion Bioscience As | A system for monitoring properties of a single cell |
JP4582146B2 (ja) * | 2006-05-17 | 2010-11-17 | パナソニック株式会社 | 細胞電位測定デバイスとそれに用いる基板、細胞電位測定デバイス用基板の製造方法 |
WO2008004476A1 (fr) | 2006-07-06 | 2008-01-10 | Panasonic Corporation | Dispositif pour capteur cellulaire électrophysiologique, capteur cellulaire électrophysiologique utilisant le dispositif, et procédé de fabrication du dispositif pour capteur cellulaire électrophysiologique |
US8836212B2 (en) * | 2007-01-11 | 2014-09-16 | Qd Vision, Inc. | Light emissive printed article printed with quantum dot ink |
JP5458887B2 (ja) | 2007-09-11 | 2014-04-02 | パナソニック株式会社 | シリコン構造体およびセンサチップ |
US8082160B2 (en) | 2007-10-26 | 2011-12-20 | Hill-Rom Services, Inc. | System and method for collection and communication of data from multiple patient care devices |
EP2302375B1 (de) * | 2009-09-29 | 2012-09-12 | Karlsruher Institut für Technologie | Verfahren und Vorrichtung zum Erfassen der Stromspannungskurve einer Zelle |
WO2011068057A1 (ja) * | 2009-12-01 | 2011-06-09 | ニプロ株式会社 | 細胞電位測定容器及びその製造方法 |
JP5659698B2 (ja) * | 2010-10-29 | 2015-01-28 | ソニー株式会社 | 試料流入装置、試料流入チップ及び試料流入方法 |
CA2903481A1 (en) * | 2013-03-13 | 2014-10-09 | The University Of North Carolina At Chapel Hill | Nanofluidic devices for the rapid mapping of whole genomes and related systems and methods of analysis |
CN105555945B (zh) * | 2013-08-30 | 2018-05-04 | 国立研究开发法人科学技术振兴机构 | 平面膜片钳装置以及平面膜片钳系统 |
KR20160113136A (ko) * | 2014-01-30 | 2016-09-28 | 나미키 세이미츠 호오세키 가부시키가이샤 | 세포막 관찰 및 해석 장치, 세포막 관찰 및 해석 방법 |
DE102014008606B3 (de) * | 2014-06-10 | 2015-08-27 | Universität Rostock | Elektrophysiologische Messanordnung und elektrophysiologisches Messverfahren |
JP2017518752A (ja) | 2014-06-12 | 2017-07-13 | ウエハージェン インコーポレイテッド | 捕捉用重合体膜を用いた単細胞捕捉 |
US9757707B2 (en) * | 2014-06-12 | 2017-09-12 | Takara Bio Usa, Inc. | Single cell capture with capture chips |
WO2017074934A1 (en) * | 2015-10-28 | 2017-05-04 | Wafergen, Inc. | Single cell capture with capture chips |
US10360787B2 (en) | 2016-05-05 | 2019-07-23 | Hill-Rom Services, Inc. | Discriminating patient care communications system |
DE102017130518B4 (de) * | 2017-12-19 | 2024-04-18 | ChanPharm GmbH | Messgerät, Messverfahren, Hochdurchsatz-Testgerät und Messkit für elektrophysiologische Messungen, insbesondere an Zellaggregaten |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5262128A (en) * | 1989-10-23 | 1993-11-16 | The United States Of America As Represented By The Department Of Health And Human Services | Array-type multiple cell injector |
EP0627621A1 (de) * | 1993-06-04 | 1994-12-07 | AVL Medical Instruments AG | Einrichtung und Verfahren zur Untersuchung des Stoffwechsels von Zellen |
EP0689051A2 (de) * | 1994-06-13 | 1995-12-27 | Matsushita Electric Industrial Co., Ltd. | Zellpotentialmessvorrichtung mit mehreren Mikroelektroden |
WO1997005922A2 (de) * | 1995-08-10 | 1997-02-20 | Nmi Naturwissenschaftliches Und Medizinisches Institut | Mikroelektroden-anordnung |
DE19646505A1 (de) * | 1996-11-12 | 1998-05-14 | Itt Ind Gmbh Deutsche | Vorrichtung zur Durchführung von Untersuchungen an Zellproben und dergleichen |
DE19712309A1 (de) * | 1996-11-16 | 1998-05-20 | Nmi Univ Tuebingen | Mikroelementenanordnung, Verfahren zum Kontaktieren von in einer flüssigen Umgebung befindlichen Zellen und Verfahren zum Herstellen einer Mikroelementenanordnung |
DE19841337C1 (de) * | 1998-05-27 | 1999-09-23 | Micronas Intermetall Gmbh | Verfahren und Vorrichtung zur intrazellulären Manipulation einer biologischen Zelle |
DE19827957A1 (de) * | 1998-05-27 | 1999-12-09 | Micronas Intermetall Gmbh | Verfahren und Vorrichtung zur Messung eines Zellpotentiales |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2727316B2 (ja) * | 1986-09-12 | 1998-03-11 | 株式会社 アドバンス | 流体集積素子 |
JPH01141582A (ja) * | 1987-11-27 | 1989-06-02 | Shimadzu Corp | 遺伝子導入装置 |
JPH0687782B2 (ja) * | 1988-11-10 | 1994-11-09 | 浜松ホトニクス株式会社 | 細胞電気穿孔法およびその装置 |
US5489515A (en) | 1993-12-09 | 1996-02-06 | Avl Medical Instruments Ag | Device for analyzing the metabolism of cells |
EP0938674B1 (de) * | 1996-11-16 | 2005-06-01 | NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen in Reutlingen Stiftung Bürgerlichen Rechts | Mikroelementenanordnung, verfahren zum kontaktieren von in einer flüssigen umgebung befindlichen zellen und verfahren zum herstellen einer mikroelementenanordnung |
DE60025929T2 (de) * | 1999-10-01 | 2006-11-09 | Sophion Bioscience A/S | Anordnung und verfahren zum feststellen und/oder überwachen elektrophysiologischer eigenschaften von ionenkanälen |
-
1999
- 1999-10-08 DE DE19948473A patent/DE19948473A1/de not_active Ceased
-
2000
- 2000-09-12 EP EP00962475A patent/EP1218736B1/de not_active Expired - Lifetime
- 2000-09-12 JP JP2001530574A patent/JP2003511699A/ja active Pending
- 2000-09-12 AU AU74190/00A patent/AU7419000A/en not_active Abandoned
- 2000-09-12 WO PCT/EP2000/008895 patent/WO2001027614A1/de active IP Right Grant
- 2000-09-12 AT AT00962475T patent/ATE349008T1/de active
- 2000-09-12 ES ES00962475T patent/ES2280241T3/es not_active Expired - Lifetime
- 2000-09-12 PT PT00962475T patent/PT1218736E/pt unknown
- 2000-09-12 DE DE50013889T patent/DE50013889D1/de not_active Expired - Lifetime
- 2000-09-12 DK DK00962475T patent/DK1218736T3/da active
-
2002
- 2002-11-20 US US10/302,163 patent/US6984297B2/en not_active Expired - Lifetime
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5262128A (en) * | 1989-10-23 | 1993-11-16 | The United States Of America As Represented By The Department Of Health And Human Services | Array-type multiple cell injector |
EP0627621A1 (de) * | 1993-06-04 | 1994-12-07 | AVL Medical Instruments AG | Einrichtung und Verfahren zur Untersuchung des Stoffwechsels von Zellen |
EP0689051A2 (de) * | 1994-06-13 | 1995-12-27 | Matsushita Electric Industrial Co., Ltd. | Zellpotentialmessvorrichtung mit mehreren Mikroelektroden |
WO1997005922A2 (de) * | 1995-08-10 | 1997-02-20 | Nmi Naturwissenschaftliches Und Medizinisches Institut | Mikroelektroden-anordnung |
DE19646505A1 (de) * | 1996-11-12 | 1998-05-14 | Itt Ind Gmbh Deutsche | Vorrichtung zur Durchführung von Untersuchungen an Zellproben und dergleichen |
DE19712309A1 (de) * | 1996-11-16 | 1998-05-20 | Nmi Univ Tuebingen | Mikroelementenanordnung, Verfahren zum Kontaktieren von in einer flüssigen Umgebung befindlichen Zellen und Verfahren zum Herstellen einer Mikroelementenanordnung |
DE19841337C1 (de) * | 1998-05-27 | 1999-09-23 | Micronas Intermetall Gmbh | Verfahren und Vorrichtung zur intrazellulären Manipulation einer biologischen Zelle |
DE19827957A1 (de) * | 1998-05-27 | 1999-12-09 | Micronas Intermetall Gmbh | Verfahren und Vorrichtung zur Messung eines Zellpotentiales |
Non-Patent Citations (1)
Title |
---|
E. NEHER AND B. SAKMANN: "Single channel currents recorded from membrane of denervated frog muscle fibers", NATURE, vol. 260, 1976, London, pages 799 - 802, XP000943702 * |
Cited By (106)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6682649B1 (en) | 1999-10-01 | 2004-01-27 | Sophion Bioscience A/S | Substrate and a method for determining and/or monitoring electrophysiological properties of ion channels |
EP1250596A1 (de) * | 1999-12-24 | 2002-10-23 | AstraZeneca AB | Vorrichtung und verfahren zum ausführen von elektrischen messungen an einem gegenstand |
WO2002004943A3 (en) * | 2000-07-07 | 2003-03-13 | Bristol Myers Squibb Co | Electrophysiology configuration suitable for high throughput screening of compounds for drug discovery |
WO2002004943A2 (en) * | 2000-07-07 | 2002-01-17 | Bristol-Myers Squibb Company | Electrophysiology configuration suitable for high throughput screening of compounds for drug discovery |
EP1283985B1 (de) * | 2000-07-31 | 2006-06-07 | Flyion GmbH | Verfahren und vorrichtung für patch-clamp-messungen an zellen |
US6932893B2 (en) | 2000-10-02 | 2005-08-23 | Sophion Bioscience A/S | System for electrophysiological measurements |
WO2002029402A3 (en) * | 2000-10-02 | 2002-07-18 | Sophion Bioscience As | System for electrophysiological measurements |
GB2401689B (en) * | 2000-10-11 | 2005-03-16 | Axon Instr Inc | Parallel electrode assembly and method of positioning cells for electrophysiological testing |
GB2401689A (en) * | 2000-10-11 | 2004-11-17 | Axon Instr Inc | A multi-chamber electrode assembly |
US6776896B1 (en) | 2000-10-11 | 2004-08-17 | Axon Instruments, Inc. | Method of positioning cells for electrophysiological testing |
US9051604B2 (en) | 2001-02-14 | 2015-06-09 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
US9528142B2 (en) | 2001-02-14 | 2016-12-27 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
US7968305B2 (en) | 2001-03-24 | 2011-06-28 | Aviva Biosciences Corporation | Biochips including ion transport detecting structures and methods of use |
US9146221B2 (en) | 2001-03-24 | 2015-09-29 | Aviva Biosciences Corporation | High-density ion transport measurement biochip devices and methods |
US10619191B2 (en) | 2001-03-28 | 2020-04-14 | Handylab, Inc. | Systems and methods for thermal actuation of microfluidic devices |
US10571935B2 (en) | 2001-03-28 | 2020-02-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
US9259735B2 (en) | 2001-03-28 | 2016-02-16 | Handylab, Inc. | Methods and systems for control of microfluidic devices |
US9677121B2 (en) | 2001-03-28 | 2017-06-13 | Handylab, Inc. | Systems and methods for thermal actuation of microfluidic devices |
US7829025B2 (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices |
US8420015B2 (en) | 2001-03-28 | 2013-04-16 | Handylab, Inc. | Systems and methods for thermal actuation of microfluidic devices |
US10351901B2 (en) | 2001-03-28 | 2019-07-16 | Handylab, Inc. | Systems and methods for thermal actuation of microfluidic devices |
US8894947B2 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Systems and methods for thermal actuation of microfluidic devices |
US8895311B1 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
JP2005514718A (ja) * | 2001-07-26 | 2005-05-19 | ハンディラブ・インコーポレーテッド | マイクロフルイディック処理方法及びシステム |
US9028773B2 (en) | 2001-09-12 | 2015-05-12 | Handylab, Inc. | Microfluidic devices having a reduced number of input and output connections |
US8043581B2 (en) | 2001-09-12 | 2011-10-25 | Handylab, Inc. | Microfluidic devices having a reduced number of input and output connections |
US7723029B2 (en) | 2002-01-24 | 2010-05-25 | Aviva Biosciences Corporation | Biochips including ion transport detecting structures and methods of use |
JP2005517180A (ja) * | 2002-02-05 | 2005-06-09 | ザ ユニヴァーシティー コート オブ ザ ユニヴァーシティー オブ グラスゴー | 細胞検定を実施するための装置 |
EP1501924A4 (de) * | 2002-05-04 | 2006-05-24 | Aviva Biosciences Corp | Vorrichtung mit strukturen nachweisendem ionentransport und verwendungsverfahren |
EP1501924A2 (de) * | 2002-05-04 | 2005-02-02 | Aviva Biosciences Corporation | Vorrichtung mit strukturen nachweisendem ionentransport und verwendungsverfahren |
WO2003096002A1 (fr) * | 2002-05-13 | 2003-11-20 | Matsushita Electric Industrial Co., Ltd. | Instrument et procede de mesure du signal d'action d'un echantillon biologique |
WO2003104788A1 (ja) * | 2002-06-05 | 2003-12-18 | 松下電器産業株式会社 | 細胞外電位測定デバイスおよびその製造方法 |
US8202439B2 (en) | 2002-06-05 | 2012-06-19 | Panasonic Corporation | Diaphragm and device for measuring cellular potential using the same, manufacturing method of the diaphragm |
US7501278B2 (en) | 2002-06-05 | 2009-03-10 | Panasonic Corporation | Extracellular potential measuring device and method for fabricating the same |
US8232084B2 (en) | 2002-06-05 | 2012-07-31 | Panasonic Corporation | Device for measuring extracellular potential and method of manufacturing device |
US10731201B2 (en) | 2003-07-31 | 2020-08-04 | Handylab, Inc. | Processing particle-containing samples |
US10865437B2 (en) | 2003-07-31 | 2020-12-15 | Handylab, Inc. | Processing particle-containing samples |
US9670528B2 (en) | 2003-07-31 | 2017-06-06 | Handylab, Inc. | Processing particle-containing samples |
US11078523B2 (en) | 2003-07-31 | 2021-08-03 | Handylab, Inc. | Processing particle-containing samples |
US10604788B2 (en) | 2004-05-03 | 2020-03-31 | Handylab, Inc. | System for processing polynucleotide-containing samples |
US10494663B1 (en) | 2004-05-03 | 2019-12-03 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
US10443088B1 (en) | 2004-05-03 | 2019-10-15 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
US10364456B2 (en) | 2004-05-03 | 2019-07-30 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
US11441171B2 (en) | 2004-05-03 | 2022-09-13 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
US10821436B2 (en) | 2006-03-24 | 2020-11-03 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using the same |
US10843188B2 (en) | 2006-03-24 | 2020-11-24 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using the same |
US11959126B2 (en) | 2006-03-24 | 2024-04-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US11666903B2 (en) | 2006-03-24 | 2023-06-06 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using same |
US9802199B2 (en) | 2006-03-24 | 2017-10-31 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US10799862B2 (en) | 2006-03-24 | 2020-10-13 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using same |
US9080207B2 (en) | 2006-03-24 | 2015-07-14 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US11141734B2 (en) | 2006-03-24 | 2021-10-12 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US11142785B2 (en) | 2006-03-24 | 2021-10-12 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US11085069B2 (en) | 2006-03-24 | 2021-08-10 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US8883490B2 (en) | 2006-03-24 | 2014-11-11 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US10913061B2 (en) | 2006-03-24 | 2021-02-09 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using the same |
US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US9040288B2 (en) | 2006-03-24 | 2015-05-26 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using the same |
US10857535B2 (en) | 2006-03-24 | 2020-12-08 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using same |
US10695764B2 (en) | 2006-03-24 | 2020-06-30 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US10821446B1 (en) | 2006-03-24 | 2020-11-03 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US8071363B2 (en) | 2006-05-25 | 2011-12-06 | Panasonic Corporation | Chip for cell electrophysiological sensor, cell electrophysiological sensor using the same, and manufacturing method of chip for cell electrophysiological sensor |
US9815057B2 (en) | 2006-11-14 | 2017-11-14 | Handylab, Inc. | Microfluidic cartridge and method of making same |
US10710069B2 (en) | 2006-11-14 | 2020-07-14 | Handylab, Inc. | Microfluidic valve and method of making same |
US9347586B2 (en) | 2007-07-13 | 2016-05-24 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
US10065185B2 (en) | 2007-07-13 | 2018-09-04 | Handylab, Inc. | Microfluidic cartridge |
US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US10625261B2 (en) | 2007-07-13 | 2020-04-21 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US10625262B2 (en) | 2007-07-13 | 2020-04-21 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
US10632466B1 (en) | 2007-07-13 | 2020-04-28 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US10590410B2 (en) | 2007-07-13 | 2020-03-17 | Handylab, Inc. | Polynucleotide capture materials, and methods of using same |
US11845081B2 (en) | 2007-07-13 | 2023-12-19 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US10717085B2 (en) | 2007-07-13 | 2020-07-21 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US9701957B2 (en) | 2007-07-13 | 2017-07-11 | Handylab, Inc. | Reagent holder, and kits containing same |
US11549959B2 (en) | 2007-07-13 | 2023-01-10 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
US9238223B2 (en) | 2007-07-13 | 2016-01-19 | Handylab, Inc. | Microfluidic cartridge |
US9259734B2 (en) | 2007-07-13 | 2016-02-16 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US11466263B2 (en) | 2007-07-13 | 2022-10-11 | Handylab, Inc. | Diagnostic apparatus to extract nucleic acids including a magnetic assembly and a heater assembly |
US11266987B2 (en) | 2007-07-13 | 2022-03-08 | Handylab, Inc. | Microfluidic cartridge |
US10844368B2 (en) | 2007-07-13 | 2020-11-24 | Handylab, Inc. | Diagnostic apparatus to extract nucleic acids including a magnetic assembly and a heater assembly |
US11254927B2 (en) | 2007-07-13 | 2022-02-22 | Handylab, Inc. | Polynucleotide capture materials, and systems using same |
US10234474B2 (en) | 2007-07-13 | 2019-03-19 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
US10179910B2 (en) | 2007-07-13 | 2019-01-15 | Handylab, Inc. | Rack for sample tubes and reagent holders |
US9217143B2 (en) | 2007-07-13 | 2015-12-22 | Handylab, Inc. | Polynucleotide capture materials, and methods of using same |
US10875022B2 (en) | 2007-07-13 | 2020-12-29 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US10139012B2 (en) | 2007-07-13 | 2018-11-27 | Handylab, Inc. | Integrated heater and magnetic separator |
US10071376B2 (en) | 2007-07-13 | 2018-09-11 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US11060082B2 (en) | 2007-07-13 | 2021-07-13 | Handy Lab, Inc. | Polynucleotide capture materials, and systems using same |
US10100302B2 (en) | 2007-07-13 | 2018-10-16 | Handylab, Inc. | Polynucleotide capture materials, and methods of using same |
USD787087S1 (en) | 2008-07-14 | 2017-05-16 | Handylab, Inc. | Housing |
US11788127B2 (en) | 2011-04-15 | 2023-10-17 | Becton, Dickinson And Company | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
US9765389B2 (en) | 2011-04-15 | 2017-09-19 | Becton, Dickinson And Company | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
US10781482B2 (en) | 2011-04-15 | 2020-09-22 | Becton, Dickinson And Company | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
US9480983B2 (en) | 2011-09-30 | 2016-11-01 | Becton, Dickinson And Company | Unitized reagent strip |
US10076754B2 (en) | 2011-09-30 | 2018-09-18 | Becton, Dickinson And Company | Unitized reagent strip |
USD905269S1 (en) | 2011-09-30 | 2020-12-15 | Becton, Dickinson And Company | Single piece reagent holder |
USD831843S1 (en) | 2011-09-30 | 2018-10-23 | Becton, Dickinson And Company | Single piece reagent holder |
USD742027S1 (en) | 2011-09-30 | 2015-10-27 | Becton, Dickinson And Company | Single piece reagent holder |
US9222954B2 (en) | 2011-09-30 | 2015-12-29 | Becton, Dickinson And Company | Unitized reagent strip |
US11453906B2 (en) | 2011-11-04 | 2022-09-27 | Handylab, Inc. | Multiplexed diagnostic detection apparatus and methods |
US10822644B2 (en) | 2012-02-03 | 2020-11-03 | Becton, Dickinson And Company | External files for distribution of molecular diagnostic tests and determination of compatibility between tests |
US9890955B2 (en) | 2012-08-24 | 2018-02-13 | Ansaldo Energia Switzerland AG | Sequential combustion with dilution gas mixer |
US10634357B2 (en) | 2012-08-24 | 2020-04-28 | Ansaldo Energia Switzerland AG | Sequential combustion with dilution gas mixer |
Also Published As
Publication number | Publication date |
---|---|
PT1218736E (pt) | 2007-04-30 |
AU7419000A (en) | 2001-04-23 |
US6984297B2 (en) | 2006-01-10 |
DE50013889D1 (de) | 2007-02-01 |
JP2003511699A (ja) | 2003-03-25 |
ES2280241T3 (es) | 2007-09-16 |
EP1218736B1 (de) | 2006-12-20 |
EP1218736A1 (de) | 2002-07-03 |
US20030080314A1 (en) | 2003-05-01 |
DK1218736T3 (da) | 2007-03-05 |
ATE349008T1 (de) | 2007-01-15 |
DE19948473A1 (de) | 2001-04-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1218736B1 (de) | Vorrichtung zum messen an in einer flüssigen umgebung befindlichen zellen | |
DE60025929T2 (de) | Anordnung und verfahren zum feststellen und/oder überwachen elektrophysiologischer eigenschaften von ionenkanälen | |
DE60018473T2 (de) | Vorrichtung und verfahren zur ausführung elektrischer messungen an gegenständen | |
EP1311655B1 (de) | Vorrichtung und verfahren zum elektrischen kontaktieren von in einer flüssigkeit in suspension befindlichen biologischen zellen | |
EP0938674B1 (de) | Mikroelementenanordnung, verfahren zum kontaktieren von in einer flüssigen umgebung befindlichen zellen und verfahren zum herstellen einer mikroelementenanordnung | |
DE19841337C1 (de) | Verfahren und Vorrichtung zur intrazellulären Manipulation einer biologischen Zelle | |
DE60120396T2 (de) | Verfahren und vorrichtung für patch-clamp-messungen an zellen | |
DE19822123C2 (de) | Verfahren und Vorrichtung zum Nachweis von Analyten | |
DE102010022929B4 (de) | Verfahren zum Herstellen einer Bilipidschicht sowie Mikrostruktur und Messanordnung | |
WO2002066596A2 (de) | Vorrichtung und verfahren zur untersuchung von ionenkanälen in membranen | |
DE60311973T2 (de) | Substrat und verfahren zum messen elektrophysiologischer eigenschaften von zellmembranen | |
EP3169993B1 (de) | Referenzelektrodenanordnung für elektrochemischen sensor und elektrochemischer sensor | |
DE602004005681T2 (de) | Kapillarsperre | |
DE102011120394B4 (de) | Verfahren und Mikrostrukturvorrichtung zur elektrischen Kontaktierung biologischer Zellen | |
DE102005030858A1 (de) | Elektrodenanordnung, deren Verwendung sowie Verfahren zu deren Herstellung | |
EP2663860B1 (de) | Mikrostrukturvorrichtung zur messung an molekularen membranen und ein verfahren zur herstellung dieser mikrostrukturvorrichtung | |
DE102014203280B4 (de) | Vorrichtung zur Bestimmung von Messgrößen an Membranen | |
DE10244129B4 (de) | H+-K+-ATPase-Assay | |
EP2663861B1 (de) | Verfahren zur automatisierten herstellung einer molekülschicht aus amphiphilen molekülen und vorrichtung zum herstellen dieser molekülschicht | |
DE10320898A1 (de) | Biokompatible Sensorelektrodenanordnung und Verfahren zu deren Herstellung | |
WO2015032868A1 (de) | Vorrichtung und verfahren zur messung an membranen und zellen | |
DE102019129042A1 (de) | Elektrophysiologisches Messgerät und Messverfahren zur Erfassung mindestens eines elektrischen Messwerts an einer biologischen Zellprobe | |
DE10349492A1 (de) | Perfusionsvorrichtung zur Behandlung und Untersuchung eines Objektes in einer Flüssigkeit |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
ENP | Entry into the national phase |
Ref country code: JP Ref document number: 2001 530574 Kind code of ref document: A Format of ref document f/p: F |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2000962475 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 2000962475 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWG | Wipo information: grant in national office |
Ref document number: 2000962475 Country of ref document: EP |