WO2001029537A3 - Method and apparatus for monitoring solid phase chemical reactions - Google Patents

Method and apparatus for monitoring solid phase chemical reactions Download PDF

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Publication number
WO2001029537A3
WO2001029537A3 PCT/US2000/028218 US0028218W WO0129537A3 WO 2001029537 A3 WO2001029537 A3 WO 2001029537A3 US 0028218 W US0028218 W US 0028218W WO 0129537 A3 WO0129537 A3 WO 0129537A3
Authority
WO
WIPO (PCT)
Prior art keywords
monitoring
reaction
solid phase
phase chemical
chemical reactions
Prior art date
Application number
PCT/US2000/028218
Other languages
French (fr)
Other versions
WO2001029537A2 (en
Inventor
Joanne Elizabeth Anderson
Frank Joseph Tarczynski
Dwight Sherod Walker
Original Assignee
Glaxo Group Ltd
Joanne Elizabeth Anderson
Frank Joseph Tarczynski
Dwight Sherod Walker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd, Joanne Elizabeth Anderson, Frank Joseph Tarczynski, Dwight Sherod Walker filed Critical Glaxo Group Ltd
Priority to AU80154/00A priority Critical patent/AU8015400A/en
Priority to JP2001532079A priority patent/JP2003512615A/en
Priority to EP00970831A priority patent/EP1221037A2/en
Publication of WO2001029537A2 publication Critical patent/WO2001029537A2/en
Publication of WO2001029537A3 publication Critical patent/WO2001029537A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00691—Automatic using robots
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00693—Means for quality control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00695—Synthesis control routines, e.g. using computer programs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Abstract

A method for monitoring a solid phase chemical reaction comprises the steps of: (a) providing a reaction mixture comprising a solid support and a reaction medium, (b) contacting an attenuated total reflection element to said reaction mixture; and then (c) monitoring the chemical reaction on the solid support through the attenuated total reflection element. The monitoring step is carried out by attenuated total reflection spectroscopy. An advantage of the invention is that the chemical reaction on the solid support may be directly monitored, rather than indirectly monitoring that chemical reaction by monitoring reaction constituents in the reaction medium.
PCT/US2000/028218 1999-10-15 2000-10-12 Method and apparatus for monitoring solid phase chemical reactions WO2001029537A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU80154/00A AU8015400A (en) 1999-10-15 2000-10-12 Method and apparatus for monitoring solid phase chemical reactions
JP2001532079A JP2003512615A (en) 1999-10-15 2000-10-12 Method and apparatus for monitoring solid phase chemical reactions
EP00970831A EP1221037A2 (en) 1999-10-15 2000-10-12 Method and apparatus for monitoring solid phase chemical reactions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15967399P 1999-10-15 1999-10-15
US60/159,673 1999-10-15

Publications (2)

Publication Number Publication Date
WO2001029537A2 WO2001029537A2 (en) 2001-04-26
WO2001029537A3 true WO2001029537A3 (en) 2001-11-29

Family

ID=22573502

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/028218 WO2001029537A2 (en) 1999-10-15 2000-10-12 Method and apparatus for monitoring solid phase chemical reactions

Country Status (4)

Country Link
EP (1) EP1221037A2 (en)
JP (1) JP2003512615A (en)
AU (1) AU8015400A (en)
WO (1) WO2001029537A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7283245B2 (en) * 2004-01-20 2007-10-16 General Electric Company Handheld device with a disposable element for chemical analysis of multiple analytes
JP4765059B2 (en) * 2005-02-10 2011-09-07 国立大学法人北海道大学 Cognitive task response measurement system and cognitive task response measurement method
DE102005048807B3 (en) * 2005-10-10 2006-11-16 Johann Wolfgang Goethe-Universität Apparatus for quantitative or qualitative determination of infrared active contents of liquid based or non-liquid fluids
TW200944776A (en) 2008-03-04 2009-11-01 Kurashiki Boseki Kk Total reflection attenuation type far-ultraviolet spectroscopy and concentration measurement device using the spectroscopy
JP5982663B2 (en) * 2011-12-13 2016-08-31 株式会社Ｕｂｅ科学分析センター Infrared spectrometer for measuring electrolyte of lithium ion secondary battery and measuring method thereof

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4582809A (en) * 1982-06-14 1986-04-15 Myron J. Block Apparatus including optical fiber for fluorescence immunoassay
US5313264A (en) * 1988-11-10 1994-05-17 Pharmacia Biosensor Ab Optical biosensor system
WO1994019694A1 (en) * 1993-02-19 1994-09-01 Arris Pharmaceutical Corporation Thin film hpmp matrix systems and methods for constructing and displaying ligands
US5565324A (en) * 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5780603A (en) * 1996-11-15 1998-07-14 Synsorb Biotech, Inc. Combinatorial synthesis of carbohydrate libraries
US5817751A (en) * 1994-06-23 1998-10-06 Affymax Technologies N.V. Method for synthesis of diketopiperazine and diketomorpholine derivatives
WO1999004228A2 (en) * 1997-07-16 1999-01-28 Ljl Biosystems, Inc. Light detection device
US5942387A (en) * 1996-08-26 1999-08-24 Eli Lilly And Company Combinatorial process for preparing substituted thiophene libraries
US5965719A (en) * 1996-11-15 1999-10-12 Sunsorb Biotech, Inc. Combinatorial synthesis of carbohydrate libraries

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4582809A (en) * 1982-06-14 1986-04-15 Myron J. Block Apparatus including optical fiber for fluorescence immunoassay
US5313264A (en) * 1988-11-10 1994-05-17 Pharmacia Biosensor Ab Optical biosensor system
US5565324A (en) * 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
WO1994019694A1 (en) * 1993-02-19 1994-09-01 Arris Pharmaceutical Corporation Thin film hpmp matrix systems and methods for constructing and displaying ligands
US5817751A (en) * 1994-06-23 1998-10-06 Affymax Technologies N.V. Method for synthesis of diketopiperazine and diketomorpholine derivatives
US5942387A (en) * 1996-08-26 1999-08-24 Eli Lilly And Company Combinatorial process for preparing substituted thiophene libraries
US5780603A (en) * 1996-11-15 1998-07-14 Synsorb Biotech, Inc. Combinatorial synthesis of carbohydrate libraries
US5965719A (en) * 1996-11-15 1999-10-12 Sunsorb Biotech, Inc. Combinatorial synthesis of carbohydrate libraries
WO1999004228A2 (en) * 1997-07-16 1999-01-28 Ljl Biosystems, Inc. Light detection device

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BIRNBAUM S ET AL: "PEPTIDE SCREENING", CURRENT OPINION IN BIOTECHNOLOGY,GB,LONDON, vol. 3, 1992, pages 49 - 54, XP000651934, ISSN: 0958-1669 *

Also Published As

Publication number Publication date
EP1221037A2 (en) 2002-07-10
JP2003512615A (en) 2003-04-02
AU8015400A (en) 2001-04-30
WO2001029537A2 (en) 2001-04-26

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