WO2001030288A1 - Oral transmucosal drug dosage using solid solution - Google Patents
Oral transmucosal drug dosage using solid solution Download PDFInfo
- Publication number
- WO2001030288A1 WO2001030288A1 PCT/US2000/028113 US0028113W WO0130288A1 WO 2001030288 A1 WO2001030288 A1 WO 2001030288A1 US 0028113 W US0028113 W US 0028113W WO 0130288 A1 WO0130288 A1 WO 0130288A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- formulation
- drug
- pharmaceutical agent
- agent
- dissolution
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT00972083T ATE468845T2 (en) | 1999-10-27 | 2000-10-12 | BUCCAL TRANSMUCOSAL DRUG DELIVERY USING A SOLID SOLUTION |
ES00972083.0T ES2345870T5 (en) | 1999-10-27 | 2000-10-12 | Dosage of oral transmucosal drugs using a solid solution |
AU10797/01A AU1079701A (en) | 1999-10-27 | 2000-10-12 | Oral transmucosal drug dosage using solid solution |
DE60044464T DE60044464D1 (en) | 1999-10-27 | 2000-10-12 | BUKKALE TRANSMUCOSAL DRUG CLEANING USING A SOLID SOLUTION |
CA002388610A CA2388610C (en) | 1999-10-27 | 2000-10-12 | Oral transmucosal drug dosage using solid solution |
EP00972083.0A EP1242013B2 (en) | 1999-10-27 | 2000-10-12 | Oral transmucosal drug dosage using solid solution |
MXPA02004235A MXPA02004235A (en) | 1999-10-27 | 2000-10-12 | Oral transmucosal drug dosage using solid solution. |
JP2001532709A JP4815084B2 (en) | 1999-10-27 | 2000-10-12 | Oral transmucosal drug dosage form using solid solution |
HK03102146.6A HK1050313A1 (en) | 1999-10-27 | 2003-03-25 | Oral transmucosal drug dosage using solid solution |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/428,071 | 1999-10-27 | ||
US09/428,071 US6264981B1 (en) | 1999-10-27 | 1999-10-27 | Oral transmucosal drug dosage using solid solution |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2001030288A1 true WO2001030288A1 (en) | 2001-05-03 |
Family
ID=23697434
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/028113 WO2001030288A1 (en) | 1999-10-27 | 2000-10-12 | Oral transmucosal drug dosage using solid solution |
Country Status (12)
Country | Link |
---|---|
US (1) | US6264981B1 (en) |
EP (1) | EP1242013B2 (en) |
JP (2) | JP4815084B2 (en) |
AT (1) | ATE468845T2 (en) |
AU (1) | AU1079701A (en) |
CA (1) | CA2388610C (en) |
DE (1) | DE60044464D1 (en) |
ES (1) | ES2345870T5 (en) |
HK (1) | HK1050313A1 (en) |
MX (1) | MXPA02004235A (en) |
PT (1) | PT1242013E (en) |
WO (1) | WO2001030288A1 (en) |
Cited By (51)
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---|---|---|---|---|
WO2004041239A1 (en) * | 2002-11-08 | 2004-05-21 | Lts Lohmann Therapie-Systeme Ag | Transmucosal pharmaceutical administration form |
WO2004069198A2 (en) * | 2003-02-04 | 2004-08-19 | Cephalon, Inc. | Sugar-free oral transmucosal solid dosage forms and uses thereof |
DE102005003387A1 (en) * | 2004-09-01 | 2006-03-02 | LABTEC Gesellschaft für technologische Forschung und Entwicklung mbH | Plaster for administering active agents through body orifices, comprises adhesive and backing layers, both made of nonionic and anionic hydrocolloids in reverse ratios |
JP2006513238A (en) * | 2002-12-19 | 2006-04-20 | ファルマシア・コーポレーション | Non-hygroscopic formulations containing hygroscopic drugs |
JP2006519187A (en) * | 2003-02-28 | 2006-08-24 | アルカベロ アクチェセルスカプ | Dosage form with saccharide matrix |
WO2007009801A3 (en) * | 2005-07-20 | 2007-06-21 | Hexal Ag | Oral, quickly disintegrating film, which cannot be spit out, for a neuroleptic drug |
EP1803443A2 (en) * | 2002-12-20 | 2007-07-04 | NicoNovum AB | A method for the preparation of a nicotine-containing particulate material with a crystalline cellulose (in particular MCC) |
WO2007085498A1 (en) * | 2006-01-24 | 2007-08-02 | Bayer Schering Pharma Aktiengesellschaft | Pharmaceutical forms in film form for use in the mouth (wafers) |
WO2007133141A1 (en) * | 2006-05-16 | 2007-11-22 | Mcneil Ab | Coated pharmaceutical product for intraoral delivery of nicotine comprising trometamol as buffering agent |
WO2007133140A1 (en) * | 2006-05-16 | 2007-11-22 | Mcneil Ab | Pharmaceutical product for intraoral delivery of nicotine comprising trometamol as buffering agent |
WO2008011194A2 (en) * | 2006-07-21 | 2008-01-24 | Biodelivery Sciences International, Inc. | Transmucosal delivery devices with enhanced uptake |
WO2008011177A2 (en) * | 2006-07-21 | 2008-01-24 | Jsrnti, Llc | Medicinal delivery system and related methods |
WO2008085765A3 (en) * | 2007-01-05 | 2008-11-27 | Acelrx Pharmaceuticals Inc | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
EP2308476A1 (en) * | 2003-11-19 | 2011-04-13 | Inkine Pharmaceutical Company, Inc. | Colonic purgative composition with soluble binding agent |
WO2011047143A1 (en) * | 2009-10-16 | 2011-04-21 | Acelrx Pharmaceuticals, Inc. | Compositions and methods for mild sedation, anxiolysis and analgesia in the procedural setting |
US8012505B2 (en) | 2003-02-28 | 2011-09-06 | Alk-Abello A/S | Dosage form having a saccharide matrix |
US8202535B2 (en) | 2006-01-06 | 2012-06-19 | Acelrx Pharmaceuticals, Inc. | Small-volume oral transmucosal dosage forms |
WO2013041851A1 (en) | 2011-09-19 | 2013-03-28 | Orexo Ab | New abuse-resistant pharmaceutical composition for the treatment of opioid dependence |
US8535714B2 (en) | 2006-01-06 | 2013-09-17 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
US8652378B1 (en) | 2001-10-12 | 2014-02-18 | Monosol Rx Llc | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
AU2012202628B2 (en) * | 2003-11-19 | 2014-05-15 | Salix Pharmaceuticals, Inc. | Colonic purgative composition with soluble binding agent |
US8765167B2 (en) | 2001-10-12 | 2014-07-01 | Monosol Rx, Llc | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
US8815911B2 (en) | 2012-05-02 | 2014-08-26 | Orexo Ab | Alfentanil composition for the treatment of acute pain |
US8865202B2 (en) | 1996-11-11 | 2014-10-21 | Lts Lohmann Therapie-Systeme Ag | Water soluble film for oral administration with instant wettability |
US8865211B2 (en) | 2006-01-06 | 2014-10-21 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
US8900498B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for manufacturing a resulting multi-layer pharmaceutical film |
US8900497B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for making a film having a substantially uniform distribution of components |
US8905964B2 (en) | 2006-01-06 | 2014-12-09 | Acelrx Pharmaceuticals, Inc. | Drug storage and dispensing devices and systems comprising the same |
US8906277B2 (en) | 2001-10-12 | 2014-12-09 | Monosol Rx, Llc | Process for manufacturing a resulting pharmaceutical film |
US8945592B2 (en) | 2008-11-21 | 2015-02-03 | Acelrx Pharmaceuticals, Inc. | Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same |
US9023393B2 (en) | 2003-08-04 | 2015-05-05 | Bend Research, Inc. | Pharmaceutical compositions of adsorbates of amorphous drugs and lipophilic microphase-forming materials |
US9066847B2 (en) | 2007-01-05 | 2015-06-30 | Aceirx Pharmaceuticals, Inc. | Storage and dispensing devices for administration of oral transmucosal dosage forms |
US9108340B2 (en) | 2001-10-12 | 2015-08-18 | Monosol Rx, Llc | Process for manufacturing a resulting multi-layer pharmaceutical film |
US9289583B2 (en) | 2006-01-06 | 2016-03-22 | Acelrx Pharmaceuticals, Inc. | Methods for administering small volume oral transmucosal dosage forms using a dispensing device |
US9320721B2 (en) | 2004-09-01 | 2016-04-26 | Tesa Labtec Gmbh | Mucoadhesive patch with opposite ratios of nonionic and anionic hydrocolloids in adhesive and backing layer |
CN101621994B (en) * | 2007-01-05 | 2016-06-01 | 阿塞尔Rx制药有限公司 | For treating a small amount of oral transmucosal dosage forms containing sufentanil of pain |
US9468604B2 (en) | 2001-06-22 | 2016-10-18 | Bend Research, Inc. | Pharmaceutical compositions of dispersions of drug and neutral polymers |
US9486410B2 (en) | 2002-02-01 | 2016-11-08 | Bend Research, Inc. | Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials |
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US9901539B2 (en) | 2011-12-21 | 2018-02-27 | Biodelivery Sciences International, Inc. | Transmucosal drug delivery devices for use in chronic pain relief |
US10219999B2 (en) | 2006-03-16 | 2019-03-05 | Niconovum Usa, Inc. | Snuff composition |
US10272607B2 (en) | 2010-10-22 | 2019-04-30 | Aquestive Therapeutics, Inc. | Manufacturing of small film strips |
US10285910B2 (en) | 2001-10-12 | 2019-05-14 | Aquestive Therapeutics, Inc. | Sublingual and buccal film compositions |
US10821074B2 (en) | 2009-08-07 | 2020-11-03 | Aquestive Therapeutics, Inc. | Sublingual and buccal film compositions |
US11077068B2 (en) | 2001-10-12 | 2021-08-03 | Aquestive Therapeutics, Inc. | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
US11191737B2 (en) | 2016-05-05 | 2021-12-07 | Aquestive Therapeutics, Inc. | Enhanced delivery epinephrine compositions |
US11207805B2 (en) | 2001-10-12 | 2021-12-28 | Aquestive Therapeutics, Inc. | Process for manufacturing a resulting pharmaceutical film |
US11273131B2 (en) | 2016-05-05 | 2022-03-15 | Aquestive Therapeutics, Inc. | Pharmaceutical compositions with enhanced permeation |
US11737980B2 (en) | 2020-05-18 | 2023-08-29 | Orexo Ab | Pharmaceutical composition for drug delivery |
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US11957647B2 (en) | 2021-11-25 | 2024-04-16 | Orexo Ab | Pharmaceutical composition comprising adrenaline |
Families Citing this family (202)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7153845B2 (en) * | 1998-08-25 | 2006-12-26 | Columbia Laboratories, Inc. | Bioadhesive progressive hydration tablets |
US8765177B2 (en) * | 1997-09-12 | 2014-07-01 | Columbia Laboratories, Inc. | Bioadhesive progressive hydration tablets |
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US6974590B2 (en) | 1998-03-27 | 2005-12-13 | Cima Labs Inc. | Sublingual buccal effervescent |
US6350470B1 (en) | 1998-04-29 | 2002-02-26 | Cima Labs Inc. | Effervescent drug delivery system for oral administration |
US6576250B1 (en) | 1998-03-27 | 2003-06-10 | Cima Labs Inc. | Pharmaceutical compositions for rectal and vaginal administration |
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US20020098264A1 (en) * | 1998-11-27 | 2002-07-25 | Cherukuri Subraman R. | Medicated chewing gum delivery system for nicotine |
US6358060B2 (en) | 1998-09-03 | 2002-03-19 | Jsr Llc | Two-stage transmucosal medicine delivery system for symptom relief |
US8188043B2 (en) * | 1999-07-28 | 2012-05-29 | The Board Of Trustees Of The Leland Stanford Jr. University | Nicotine in therapeutic angiogenesis and vasculogenesis |
GB0001710D0 (en) * | 2000-01-25 | 2000-03-15 | Pharma Pacific Pty Ltd | Therapeutic treatment |
GB2359747B (en) * | 2000-02-29 | 2002-04-24 | Maelor Pharmaceuticals Ltd | Anaesthetic formulations |
DE10026698A1 (en) | 2000-05-30 | 2001-12-06 | Basf Ag | Self-emulsifying active ingredient formulation and use of this formulation |
USRE44145E1 (en) | 2000-07-07 | 2013-04-09 | A.V. Topchiev Institute Of Petrochemical Synthesis | Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties |
MXPA03003152A (en) * | 2000-10-11 | 2005-07-29 | Cephalon Inc | Compositions comprising modafinil compounds. |
US20050113510A1 (en) | 2001-05-01 | 2005-05-26 | Feldstein Mikhail M. | Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components |
US8840918B2 (en) | 2001-05-01 | 2014-09-23 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Hydrogel compositions for tooth whitening |
US6803420B2 (en) | 2001-05-01 | 2004-10-12 | Corium International | Two-phase, water-absorbent bioadhesive composition |
US8206738B2 (en) | 2001-05-01 | 2012-06-26 | Corium International, Inc. | Hydrogel compositions with an erodible backing member |
US8541021B2 (en) | 2001-05-01 | 2013-09-24 | A.V. Topchiev Institute Of Petrochemical Synthesis | Hydrogel compositions demonstrating phase separation on contact with aqueous media |
US20050215727A1 (en) | 2001-05-01 | 2005-09-29 | Corium | Water-absorbent adhesive compositions and associated methods of manufacture and use |
ATE438418T1 (en) | 2001-05-01 | 2009-08-15 | Av Topchiev Inst Petrochemical | HYDROGEL COMPOSITIONS |
EP1392272B1 (en) * | 2001-05-11 | 2014-08-06 | Merrion Research III Limited | Permeation enhancers |
SE521512C2 (en) * | 2001-06-25 | 2003-11-11 | Niconovum Ab | Device for administering a substance to the front of an individual's oral cavity |
US20030068356A1 (en) * | 2001-07-10 | 2003-04-10 | Pather S. Indiran | Sequential drug delivery systems |
DE10141650C1 (en) | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Safe transdermal therapeutic system for administration of fentanyl or analogous analgesics, having matrix layer of carboxy group-free polyacrylate adhesive providing high permeation rate |
US7854230B2 (en) * | 2001-10-22 | 2010-12-21 | O.R. Solutions, Inc. | Heated medical instrument stand with surgical drape and method of detecting fluid and leaks in the stand tray |
WO2003048666A1 (en) * | 2001-11-29 | 2003-06-12 | Penwest Pharmaceutical Company | Process for co-spray drying liquid herbal extracts with dry silicified mcc |
GB0129117D0 (en) * | 2001-12-05 | 2002-01-23 | Glaxo Group Ltd | Pharmaceutical composition |
US20030159702A1 (en) * | 2002-01-21 | 2003-08-28 | Lindell Katarina E.A. | Formulation and use manufacture thereof |
JP3931680B2 (en) * | 2002-02-18 | 2007-06-20 | 株式会社日本自動車部品総合研究所 | Straight traveling discrimination device for vehicle |
US8017150B2 (en) * | 2002-04-11 | 2011-09-13 | Monosol Rx, Llc | Polyethylene oxide-based films and drug delivery systems made therefrom |
GB0210397D0 (en) * | 2002-05-07 | 2002-06-12 | Ferring Bv | Pharmaceutical formulations |
WO2003096976A2 (en) | 2002-05-14 | 2003-11-27 | Fmc Corporation | Microcrystalline cewllulose compositions |
GB0217056D0 (en) * | 2002-07-23 | 2002-08-28 | Ass Octel | Use |
KR100548925B1 (en) * | 2002-10-23 | 2006-02-02 | 한미약품 주식회사 | Sustained release composition for oral administration of a drug |
US20080213363A1 (en) * | 2003-01-23 | 2008-09-04 | Singh Nikhilesh N | Methods and compositions for delivering 5-HT3 antagonists across the oral mucosa |
US9498454B2 (en) | 2003-02-24 | 2016-11-22 | Pharmaceutical Productions Inc. | Transmucosal drug delivery system |
US9254294B2 (en) | 2003-02-24 | 2016-02-09 | Pharmaceutical Productions Inc. | Transmucosal hormone delivery system |
US9358296B2 (en) | 2003-02-24 | 2016-06-07 | Pharmaceutical Productions Inc. | Transmucosal drug delivery system |
US10172810B2 (en) | 2003-02-24 | 2019-01-08 | Pharmaceutical Productions, Inc. | Transmucosal ketamine delivery composition |
EP2316418A3 (en) * | 2003-02-24 | 2011-09-21 | Pharmaceutical Productions Inc. | Transmucosal drug delivery system |
US7648982B2 (en) * | 2003-02-28 | 2010-01-19 | Ym Biosciences Inc. | Opioid delivery system |
US7648981B2 (en) * | 2003-02-28 | 2010-01-19 | Ym Biosciences Inc. | Opioid delivery system |
US20040192781A1 (en) * | 2003-03-31 | 2004-09-30 | Haley Eugene T. | Method of administration for metoclopramide and pharmaceutical formulation therefor |
US20050137265A1 (en) * | 2003-03-31 | 2005-06-23 | Haley Eugene T. | Rapidly dissolving metoclopramide solid oral dosage and method thereof |
US20040202717A1 (en) | 2003-04-08 | 2004-10-14 | Mehta Atul M. | Abuse-resistant oral dosage forms and method of use thereof |
US20040213828A1 (en) * | 2003-04-23 | 2004-10-28 | Smith David J. | Pain relief lollipop compositions and methods |
WO2004093908A2 (en) * | 2003-04-23 | 2004-11-04 | Medarex, Inc. | Compositions and methods for the therapy of inflammatory bowel disease |
AU2004233997C1 (en) | 2003-04-29 | 2014-01-30 | Massachusetts Institiute Of Technology | Methods and devices for the sustained release of multiple drugs |
US7306812B2 (en) | 2003-05-09 | 2007-12-11 | Cephalon, Inc. | Dissolvable backing layer for use with a transmucosal delivery device |
US7276246B2 (en) * | 2003-05-09 | 2007-10-02 | Cephalon, Inc. | Dissolvable backing layer for use with a transmucosal delivery device |
US20070059346A1 (en) * | 2003-07-01 | 2007-03-15 | Todd Maibach | Film comprising therapeutic agents |
PL1648421T3 (en) * | 2003-07-24 | 2018-03-30 | Glaxosmithkline Llc | Orally dissolving films |
US20050037194A1 (en) * | 2003-08-15 | 2005-02-17 | Kimberly-Clark Worldwide, Inc. | Thermoplastic polymers with thermally reversible and non-reversible linkages, and articles using same |
US20050042281A1 (en) * | 2003-08-21 | 2005-02-24 | Singh Nikhilesh N. | Compositions for delivering therapeutic agents across the oral mucosa |
US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
GB0320854D0 (en) | 2003-09-05 | 2003-10-08 | Arrow No 7 Ltd | Buccal drug delivery |
US20050065175A1 (en) * | 2003-09-24 | 2005-03-24 | Xanodyne Pharmacal, Inc. | Oral transmucosal methadone |
US8627828B2 (en) | 2003-11-07 | 2014-01-14 | U.S. Smokeless Tobacco Company Llc | Tobacco compositions |
CN104397869B (en) | 2003-11-07 | 2016-06-08 | 美国无烟烟草有限责任公司 | Tobacco compositions |
EP1530967B1 (en) * | 2003-11-13 | 2006-05-03 | Ferring B.V. | Blister pack and solid dosage form comprising desmopressin |
US7862833B2 (en) * | 2003-12-31 | 2011-01-04 | Cima Labs, Inc. | Effervescent oral opiate dosage forms and methods of administering opiates |
CA2548915C (en) * | 2003-12-31 | 2012-10-16 | Cima Labs Inc. | Generally linear effervescent oral fentanyl dosage form and methods of administering |
WO2005065657A2 (en) * | 2003-12-31 | 2005-07-21 | Pfizer Products Inc. | Solid compositions of low-solubility drugs and poloxamers |
WO2005065317A2 (en) * | 2003-12-31 | 2005-07-21 | Cima Labs Inc. | Effervescent oral fentanyl dosage form |
JP2007517015A (en) * | 2003-12-31 | 2007-06-28 | ファイザー・プロダクツ・インク | Stabilized pharmaceutical solid composition of low solubility drug, poloxamer and stabilizing polymer |
EP1711220A1 (en) * | 2004-01-16 | 2006-10-18 | Biodel, Inc. | Sublingual drug delivery device |
WO2005074894A1 (en) | 2004-01-30 | 2005-08-18 | Corium International | Rapidly dissolving film for delivery of an active agent |
EP1715853A4 (en) * | 2004-02-17 | 2012-07-18 | Transcept Pharmaceuticals Inc | Compositions for delivering hypnotic agents across the oral mucosa and methods of use thereof |
US20080096800A1 (en) * | 2004-03-12 | 2008-04-24 | Biodel, Inc. | Rapid mucosal gel or film insulin compositions |
US20080090753A1 (en) * | 2004-03-12 | 2008-04-17 | Biodel, Inc. | Rapid Acting Injectable Insulin Compositions |
US7279457B2 (en) * | 2004-03-12 | 2007-10-09 | Biodel, Inc. | Rapid acting drug delivery compositions |
US7785619B2 (en) * | 2004-04-08 | 2010-08-31 | Micro Nutrient, Llc | Pharmanutrient composition(s) and system(s) for individualized, responsive dosing regimens |
US7850987B2 (en) * | 2004-04-08 | 2010-12-14 | Micronutrient, Llc | Nutrient composition(s) and system(s) for individualized, responsive dosing regimens |
WO2005097085A1 (en) * | 2004-04-08 | 2005-10-20 | Micro Nutrient, Llc | Nutrient system for individualized responsive dosing regimens |
ATE493973T1 (en) | 2004-06-04 | 2011-01-15 | Teva Pharma | PHARMACEUTICAL COMPOSITION CONTAINING IRBESARTAN |
CA2570823C (en) | 2004-06-21 | 2015-02-24 | Medarex, Inc. | Interferon alpha receptor 1 antibodies and their uses |
CN103497713B (en) | 2004-08-05 | 2018-07-17 | 考里安国际公司 | Adhesive composition |
CA2577852A1 (en) | 2004-08-31 | 2006-03-09 | Pfizer Products Inc. | Pharmaceutical dosage forms comprising a low-solubility drug and a polymer |
US20060051413A1 (en) * | 2004-09-08 | 2006-03-09 | Chow Sing S M | Method of enhancing absorptions of transmucosal administration formulations |
CN101098679A (en) * | 2004-11-05 | 2008-01-02 | 国王医药研究与发展有限公司 | Stabilized ramipril compositions and methods of making |
US9198448B2 (en) * | 2005-02-07 | 2015-12-01 | Intercontinental Great Brands Llc | Stable tooth whitening gum with reactive ingredients |
DE102005015128B4 (en) * | 2005-03-31 | 2008-12-11 | Bayer Schering Pharma Aktiengesellschaft | Wafers containing steroid hormones |
US20070225322A1 (en) * | 2005-05-25 | 2007-09-27 | Transoral Pharmaceuticals, Inc. | Compositions and methods for treating middle-of-the night insomnia |
US8242131B2 (en) * | 2005-05-25 | 2012-08-14 | Transcept Pharmaceuticals, Inc. | Methods of treating middle-of-the-night insomnia |
US20070287740A1 (en) * | 2005-05-25 | 2007-12-13 | Transcept Pharmaceuticals, Inc. | Compositions and methods of treating middle-of-the night insomnia |
AU2006255178A1 (en) * | 2005-06-03 | 2006-12-14 | Teva Women's Health, Inc. | Attachment of a handle to a solid oral dosage form |
US20070020186A1 (en) * | 2005-07-22 | 2007-01-25 | Alpex Pharma S.A. | Solid dosage formulations of narcotic drugs having improved buccal adsorption |
US9877921B2 (en) | 2005-09-09 | 2018-01-30 | Nova Southeastern University | Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine |
TW200800142A (en) * | 2005-09-09 | 2008-01-01 | Univ Manitoba | Fast-disintegrating epinephrine tablets for buccal or sublingual administration |
WO2014007972A2 (en) | 2012-06-15 | 2014-01-09 | Nova Southeastern University | Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinphrine |
US20160045457A1 (en) | 2005-09-09 | 2016-02-18 | Ousama Rachid | Epinephrine fine particles and methods for use thereof for treatment of conditions responsive to epinephrine |
US8084420B2 (en) * | 2005-09-29 | 2011-12-27 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
US7713929B2 (en) | 2006-04-12 | 2010-05-11 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
US7879382B2 (en) * | 2005-09-30 | 2011-02-01 | Fmc Corporation | Stabilizers and compositions and products comprising same |
US20070104763A1 (en) * | 2005-11-10 | 2007-05-10 | Navinta Llc | Composition of fentanyl citrate oral solid transmucosal dosage form, excipient and binding material therefore, and methods of making |
CN101378732A (en) * | 2006-01-06 | 2009-03-04 | 阿塞尔Rx制药有限公司 | Bioadhesive drug formulations for oral transmucosal delivery |
US8753308B2 (en) * | 2006-01-06 | 2014-06-17 | Acelrx Pharmaceuticals, Inc. | Methods for administering small volume oral transmucosal dosage forms using a dispensing device |
US8252328B2 (en) * | 2006-01-06 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
US20070172507A1 (en) * | 2006-01-26 | 2007-07-26 | Paul Zupkas | Transluminal drug delivery methods and devices |
WO2007121256A2 (en) * | 2006-04-12 | 2007-10-25 | Biodel, Inc. | Rapid acting and long acting insulin combination formulations |
US20070260491A1 (en) * | 2006-05-08 | 2007-11-08 | Pamela Palmer | System for delivery and monitoring of administration of controlled substances |
TW200817049A (en) * | 2006-06-05 | 2008-04-16 | Verus Pharmaceuticals Inc | Epinephrine dosing regimens comprising buccal, lingual or sublingual and injectable dosage forms |
US20070293581A1 (en) * | 2006-06-05 | 2007-12-20 | Malcolm Hill | Methods for Buccal, Lingual or Sublingual Dosing Regimens of Epinephrine for the Treatment of Allergic Emergencies |
DE102006027796A1 (en) * | 2006-06-16 | 2007-12-20 | Lts Lohmann Therapie-Systeme Ag | Flat form medicament preparation based on hydrophilic polymer disintegrates quickly in contact with moisture, useful e.g. to release active agent in body opening/body cavity e.g. for contraception, comprises active agent combination |
US20070299687A1 (en) * | 2006-06-23 | 2007-12-27 | Pamela Palmer | Inpatient system for patient-controlled delivery of oral transmucosal medications dosed as needed |
JP2010507676A (en) * | 2006-10-27 | 2010-03-11 | エフ エム シー コーポレーション | Dry granulating binder, product and use thereof |
WO2008091588A1 (en) | 2007-01-22 | 2008-07-31 | Targacept, Inc. | Intranasal, buccal, and sublingual administration of metanicotine analogs |
WO2008100434A1 (en) * | 2007-02-09 | 2008-08-21 | Durect Corporation | Transoral dosage forms comprising sufentanil and naloxone |
WO2008098195A2 (en) * | 2007-02-09 | 2008-08-14 | Todd Maibach | Film comprising nitroglycerin |
KR20090129998A (en) | 2007-02-11 | 2009-12-17 | 맵 파마슈티컬스, 인코포레이티드 | Method of therapeutic administration of dhe to enable rapid relief of migraine while minimizing side effect profile |
WO2008124522A2 (en) * | 2007-04-04 | 2008-10-16 | Biodel, Inc. | Amylin formulations |
WO2008124928A1 (en) * | 2007-04-13 | 2008-10-23 | Christopher Culligan | Freezable unit dosage delivery system and method of preparation |
WO2009037319A2 (en) * | 2007-09-18 | 2009-03-26 | Niconovum Ab | Stable chewing gum compositions comprising maltitol and providing rapid release of nicotine |
AU2009204309B2 (en) * | 2008-01-04 | 2012-11-22 | Biodel, Inc. | Insulin formulations for insulin release as a function of tissue glucose levels |
US8137690B2 (en) | 2008-01-17 | 2012-03-20 | Health Innovations, Llc | Taste titration therapies |
US20110082150A1 (en) * | 2008-02-11 | 2011-04-07 | Robert Owen Cook | Headache pre-emption by dihydroergotamine treatment during headache Precursor events |
US20110097405A1 (en) * | 2008-02-13 | 2011-04-28 | Bayer Schering Pharma Aktiengesellschaft | Estradiol-containing drug delivery system |
JP2011511816A (en) * | 2008-02-13 | 2011-04-14 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | Drug delivery system with stabilizing effect |
EP2293779A1 (en) * | 2008-04-24 | 2011-03-16 | Evestra, Inc. | Oral contraceptive dosage forms comprising a progestogen dispersed in an enteric polymer and further comprising an estrogen |
US20090298946A1 (en) * | 2008-06-02 | 2009-12-03 | Cleavelin Cody R | Local Anesthetic Deactivation |
ES2663777T3 (en) * | 2008-06-23 | 2018-04-17 | Biodelivery Sciences International, Inc. | Multidirectional mucosal administration devices and methods of use |
CA2736531C (en) * | 2008-09-17 | 2016-10-25 | Niconovum Ab | Process for preparing snuff composition |
AU2010204986B2 (en) | 2009-01-14 | 2016-06-02 | Corium International, Inc. | Transdermal administration of tamsulosin |
US9060927B2 (en) * | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
KR20120042836A (en) | 2009-06-12 | 2012-05-03 | 아다지오 파마슈티컬즈 엘티디 | Sublingual apomorphine |
KR101792696B1 (en) | 2009-06-18 | 2017-11-02 | 알레간 인코포레이티드 | Safe desmopressin administration |
US8475832B2 (en) | 2009-08-07 | 2013-07-02 | Rb Pharmaceuticals Limited | Sublingual and buccal film compositions |
US9125858B2 (en) | 2009-11-30 | 2015-09-08 | Wilmore Labs L.L.C. | Compositions and methods relating to resveratrol |
US20120322884A1 (en) | 2010-03-01 | 2012-12-20 | University Of Manitoba | Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine |
KR101828630B1 (en) | 2010-07-09 | 2018-02-12 | 데이진 화-마 가부시키가이샤 | Orally disintegrating tablet |
US9308213B2 (en) | 2010-10-29 | 2016-04-12 | Infirst Healthcare Limited | Solid solution compositions and use in chronic inflammation |
US9737500B2 (en) | 2010-10-29 | 2017-08-22 | Infirst Healthcare Limited | Compositions and methods for treating severe pain |
US11730709B2 (en) | 2010-10-29 | 2023-08-22 | Infirst Healthcare Limited | Compositions and methods for treating severe pain |
US10695432B2 (en) * | 2010-10-29 | 2020-06-30 | Infirst Healthcare Limited | Solid solution compositions and use in severe pain |
US10695431B2 (en) * | 2010-10-29 | 2020-06-30 | Infirst Healthcare Limited | Solid solution compositions and use in cardiovascular disease |
US9504664B2 (en) | 2010-10-29 | 2016-11-29 | Infirst Healthcare Limited | Compositions and methods for treating severe pain |
US11202831B2 (en) | 2010-10-29 | 2021-12-21 | Infirst Healthcare Limited | Solid solution compositions and use in cardiovascular disease |
US9271950B2 (en) | 2010-10-29 | 2016-03-01 | Infirst Healthcare Limited | Compositions for treating chronic inflammation and inflammatory diseases |
US8895536B2 (en) | 2010-10-29 | 2014-11-25 | Infirst Healthcare Ltd. | Compositions and methods for treating chronic inflammation and inflammatory diseases |
US9744132B2 (en) | 2010-10-29 | 2017-08-29 | Infirst Healthcare Limited | Solid solution compositions and use in chronic inflammation |
US11224659B2 (en) | 2010-10-29 | 2022-01-18 | Infirst Healthcare Limited | Solid solution compositions and use in severe pain |
KR101890317B1 (en) | 2010-12-16 | 2018-08-22 | 선오비온 파마슈티컬스 인코포레이티드 | Sublingual Films |
PL2701681T3 (en) | 2011-04-29 | 2017-03-31 | Moberg Pharma Ab | Pharmaceutical compositions comprising a local anaesthetic such as bupivacaine for local administration to the mouth or throat |
EP2708229B1 (en) | 2011-05-10 | 2019-07-31 | Itochu Chemical Frontier Corporation | Non-aqueous patch |
US9925264B2 (en) | 2011-05-10 | 2018-03-27 | Itochu Chemical Frontier Corporation | Non-aqueous patch |
US11786455B2 (en) | 2011-05-10 | 2023-10-17 | Itochu Chemical Frontier Corporation | Non-aqueous patch |
US9474303B2 (en) | 2011-09-22 | 2016-10-25 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
US9629392B2 (en) | 2011-09-22 | 2017-04-25 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
US20130078307A1 (en) | 2011-09-22 | 2013-03-28 | Niconovum Usa, Inc. | Nicotine-containing pharmaceutical composition |
US9084439B2 (en) | 2011-09-22 | 2015-07-21 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
EP2572731A1 (en) * | 2011-09-26 | 2013-03-27 | Abbott GmbH & Co. KG | Formulations based on solid dispersions |
CA2850024C (en) | 2011-09-27 | 2020-07-07 | Itochu Chemical Frontier Corporation | Non-aqueous patch comprising lidocaine |
WO2013052118A1 (en) | 2011-10-05 | 2013-04-11 | Fmc Corporation | Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses |
JP6188030B2 (en) | 2011-10-05 | 2017-08-30 | エフ エム シー コーポレーションFmc Corporation | Stabilizer composition for microcrystalline cellulose and carboxymethylcellulose, method for producing the composition, and food product |
EP2753321B1 (en) | 2011-10-21 | 2021-12-15 | Nova Southeastern University | Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine |
BR112014013792B8 (en) | 2011-12-09 | 2020-11-10 | Dupont Nutrition Usa Inc | co-rubbed stabilizing composition comprising high-substitution, low-viscosity carboxymethyl cellulose, food, industrial composition, and method for making the stabilizing composition |
US10806703B2 (en) * | 2012-01-20 | 2020-10-20 | Lts Lohmann Therapie-System Ag | Transmucosal administration system for a pharmaceutical drug |
US9763928B2 (en) | 2012-02-10 | 2017-09-19 | Niconovum Usa, Inc. | Multi-layer nicotine-containing pharmaceutical composition |
US9044035B2 (en) | 2012-04-17 | 2015-06-02 | R.J. Reynolds Tobacco Company | Remelted ingestible products |
MX356111B (en) | 2012-04-18 | 2018-05-15 | SpecGx LLC | Immediate release, abuse deterrent pharmaceutical compositions. |
US11596599B2 (en) | 2012-05-03 | 2023-03-07 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
EP2844227B1 (en) | 2012-05-03 | 2020-11-18 | Kala Pharmaceuticals, Inc. | Pharmaceutical nanoparticles showing improved mucosal transport |
US9827191B2 (en) | 2012-05-03 | 2017-11-28 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
JP6360039B2 (en) | 2012-05-03 | 2018-07-18 | カラ ファーマシューティカルズ インコーポレイテッド | Composition comprising a plurality of coated particles, pharmaceutical composition, pharmaceutical formulation and method of forming the particles |
FR2994844B1 (en) * | 2012-08-31 | 2015-01-02 | Assist Publ Hopitaux De Paris | GELIFYING FORMULATION BASED ON KETAMINE |
DK2919777T3 (en) * | 2012-11-13 | 2020-03-09 | Invictus Biotechnology Pty Ltd | TRANSMUKOSAL RELEASE OF TOCOTRIENOL |
CA2895816C (en) | 2012-12-21 | 2021-02-23 | Map Pharmaceuticals, Inc. | 8'-hydroxy-dihydroergotamine compounds and compositions |
EP2925367B1 (en) * | 2013-01-14 | 2019-08-14 | InFirst Healthcare Limited | Solid solution compositions and use in chronic inflammation |
WO2014127214A1 (en) | 2013-02-15 | 2014-08-21 | Kala Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
ES2831625T3 (en) | 2013-02-20 | 2021-06-09 | Kala Pharmaceuticals Inc | Therapeutic compounds and their uses |
US9688688B2 (en) | 2013-02-20 | 2017-06-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof |
JP6255474B2 (en) | 2013-03-15 | 2017-12-27 | マリンクロッド エルエルシー | Abuse deterrent solid dosage form for immediate release with functional secant |
WO2014140868A2 (en) * | 2013-03-15 | 2014-09-18 | Allen Davidoff | Xanthine oxidase inhibitor formulations |
PL2976072T3 (en) | 2013-03-22 | 2021-11-22 | Nova Southeastern University | Epinephrine fine particles and methods for use thereof for treatment of conditions responsive to epinephrine |
US11771127B2 (en) * | 2013-10-03 | 2023-10-03 | Altria Client Services Llc | Chewable dissolvable nicotine tablet |
US11779045B2 (en) * | 2013-10-03 | 2023-10-10 | Altria Client Services Llc | Dissolvable-chewable exhausted-tobacco tablet |
JP6426194B2 (en) | 2013-11-01 | 2018-11-21 | カラ ファーマシューティカルズ インコーポレイテッド | Crystalline forms of therapeutic compounds and uses thereof |
US9890173B2 (en) | 2013-11-01 | 2018-02-13 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
KR20160108828A (en) | 2013-11-11 | 2016-09-20 | 임팩스 라보라토리즈, 인코포레이티드 | Rapidly disintegrating formulations and methods of use |
EP3705300A1 (en) * | 2013-12-17 | 2020-09-09 | EOS GmbH Electro Optical Systems | Laser printing system |
CA2953396C (en) | 2014-07-03 | 2022-11-08 | Mallinckrodt Llc | Abuse deterrent immediate release formulations comprising non-cellulose polysaccharides |
MY187877A (en) | 2014-12-23 | 2021-10-26 | Acelrx Pharmaceuticals Inc | Systems, devices and methods for dispensing oral transmucosal dosage forms |
US9925138B2 (en) | 2015-01-20 | 2018-03-27 | Handa Pharmaceuticals, Llc | Stable solid fingolimod dosage forms |
US9925233B2 (en) | 2015-01-30 | 2018-03-27 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
US9687526B2 (en) | 2015-01-30 | 2017-06-27 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
US9750785B2 (en) | 2015-01-30 | 2017-09-05 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
US9744209B2 (en) | 2015-01-30 | 2017-08-29 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
US9937223B2 (en) | 2015-01-30 | 2018-04-10 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
US9375478B1 (en) | 2015-01-30 | 2016-06-28 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
GB201504482D0 (en) * | 2015-03-17 | 2015-04-29 | King S College London | Novel formulations |
CA3019769C (en) | 2015-04-21 | 2021-10-12 | Sunovion Pharmaceuticals Inc. | Methods of treating parkinson's disease by administration of apomorphine to an oral mucosa |
WO2017009446A1 (en) * | 2015-07-16 | 2017-01-19 | Christer Sjögren | Compositions of midazolam for buccal administration in the treatment of seizures to obtain rapid onset of action |
US10392399B2 (en) | 2016-09-08 | 2019-08-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
US10253036B2 (en) | 2016-09-08 | 2019-04-09 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
EP3509421A4 (en) | 2016-09-08 | 2020-05-20 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
US20190336453A1 (en) * | 2017-01-04 | 2019-11-07 | BonAyu Lifesciences Private Limited | Oral dispersible film composition |
US10744087B2 (en) | 2018-03-22 | 2020-08-18 | Incarda Therapeutics, Inc. | Method to slow ventricular rate |
US10369157B1 (en) | 2018-03-29 | 2019-08-06 | Mfkc 200, Llc | Multi-agent formulation |
EP3856160A4 (en) | 2018-09-25 | 2022-07-06 | SpecGx LLC | Abuse deterrent immediate release capsule dosage forms |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5449521A (en) * | 1988-11-28 | 1995-09-12 | Vectorpharma N.A. Inc. | Supported drugs with increased dissolution rate, and a process for their preparation |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2698822A (en) † | 1951-04-28 | 1955-01-04 | Fougera & Co Inc E | Cardiac glycoside buccal composition |
US3511914A (en) * | 1967-01-31 | 1970-05-12 | Schering Corp | Throat lozenge vehicle |
US3439089A (en) * | 1968-03-27 | 1969-04-15 | Merck & Co Inc | Medicated hard candy |
US3634584A (en) * | 1969-02-13 | 1972-01-11 | American Home Prod | Sustained action dosage form |
US4151273A (en) * | 1974-10-31 | 1979-04-24 | The Regents Of The University Of California | Increasing the absorption rate of insoluble drugs |
DD220225A5 (en) * | 1983-03-16 | 1985-03-27 | Boehringer Ingelheim Ltd | PROCESS FOR PREPARING A SOLID-BODY DISPERSION OF CHLORO-THALIDONE |
JPS6117510A (en) * | 1984-07-03 | 1986-01-25 | Toyobo Co Ltd | Gradually releasing preparation of nifedipine to be applied to oral cavity mucosa |
US4629621A (en) * | 1984-07-23 | 1986-12-16 | Zetachron, Inc. | Erodible matrix for sustained release bioactive composition |
US4624849A (en) * | 1984-11-02 | 1986-11-25 | The Procter & Gamble Company | Antimicrobial lozenges |
US5132114A (en) | 1985-05-01 | 1992-07-21 | University Of Utah Research Foundation | Compositions and methods of manufacture of compressed powder medicaments |
SE448889B (en) * | 1985-11-06 | 1987-03-23 | Sunds Defibrator | SET FOR TREATMENT OF RECOVERY PAPERS |
US4764378A (en) * | 1986-02-10 | 1988-08-16 | Zetachron, Inc. | Buccal drug dosage form |
US5047244A (en) * | 1988-06-03 | 1991-09-10 | Watson Laboratories, Inc. | Mucoadhesive carrier for delivery of therapeutical agent |
US5073374A (en) * | 1988-11-30 | 1991-12-17 | Schering Corporation | Fast dissolving buccal tablet |
AU659645B2 (en) † | 1991-06-26 | 1995-05-25 | Inhale Therapeutic Systems | Storage of materials |
JP3773062B2 (en) * | 1993-01-29 | 2006-05-10 | 味の素株式会社 | Pharmaceutical additives |
DK0725642T3 (en) † | 1993-10-27 | 2000-05-29 | Upjohn Co | Stabilized prostaglandin E1 |
DE19509807A1 (en) † | 1995-03-21 | 1996-09-26 | Basf Ag | Process for the preparation of active substance preparations in the form of a solid solution of the active substance in a polymer matrix, and active substance preparations produced using this method |
IT1274034B (en) | 1994-07-26 | 1997-07-14 | Applied Pharma Res | PHARMACEUTICAL COMPOSITIONS BASED ON RUBBER TO BE CHEWED AND PROCEDURE FOR THEIR PREPARATION |
JPH08291063A (en) * | 1995-04-21 | 1996-11-05 | Maruho Kk | Readily absorbable pharmaceutical preparation and its production |
DK0901786T3 (en) * | 1997-08-11 | 2007-10-08 | Pfizer Prod Inc | Solid pharmaceutical dispersions with increased bioavailability |
JP3460538B2 (en) * | 1997-10-08 | 2003-10-27 | 救急薬品工業株式会社 | Fast dissolving film preparation |
-
1999
- 1999-10-27 US US09/428,071 patent/US6264981B1/en not_active Expired - Lifetime
-
2000
- 2000-10-12 ES ES00972083.0T patent/ES2345870T5/en not_active Expired - Lifetime
- 2000-10-12 MX MXPA02004235A patent/MXPA02004235A/en active IP Right Grant
- 2000-10-12 CA CA002388610A patent/CA2388610C/en not_active Expired - Fee Related
- 2000-10-12 AT AT00972083T patent/ATE468845T2/en active
- 2000-10-12 PT PT00972083T patent/PT1242013E/en unknown
- 2000-10-12 WO PCT/US2000/028113 patent/WO2001030288A1/en active Search and Examination
- 2000-10-12 DE DE60044464T patent/DE60044464D1/en not_active Expired - Lifetime
- 2000-10-12 JP JP2001532709A patent/JP4815084B2/en not_active Expired - Fee Related
- 2000-10-12 AU AU10797/01A patent/AU1079701A/en not_active Abandoned
- 2000-10-12 EP EP00972083.0A patent/EP1242013B2/en not_active Expired - Lifetime
-
2003
- 2003-03-25 HK HK03102146.6A patent/HK1050313A1/en not_active IP Right Cessation
-
2008
- 2008-05-07 JP JP2008121345A patent/JP2008201805A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5449521A (en) * | 1988-11-28 | 1995-09-12 | Vectorpharma N.A. Inc. | Supported drugs with increased dissolution rate, and a process for their preparation |
Cited By (104)
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US8900497B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for making a film having a substantially uniform distribution of components |
US8906277B2 (en) | 2001-10-12 | 2014-12-09 | Monosol Rx, Llc | Process for manufacturing a resulting pharmaceutical film |
US10285910B2 (en) | 2001-10-12 | 2019-05-14 | Aquestive Therapeutics, Inc. | Sublingual and buccal film compositions |
US8652378B1 (en) | 2001-10-12 | 2014-02-18 | Monosol Rx Llc | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
US8765167B2 (en) | 2001-10-12 | 2014-07-01 | Monosol Rx, Llc | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
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US9108340B2 (en) | 2001-10-12 | 2015-08-18 | Monosol Rx, Llc | Process for manufacturing a resulting multi-layer pharmaceutical film |
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US11207805B2 (en) | 2001-10-12 | 2021-12-28 | Aquestive Therapeutics, Inc. | Process for manufacturing a resulting pharmaceutical film |
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US10357455B2 (en) | 2002-02-01 | 2019-07-23 | Bend Research, Inc. | Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials |
US9486410B2 (en) | 2002-02-01 | 2016-11-08 | Bend Research, Inc. | Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials |
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WO2004041239A1 (en) * | 2002-11-08 | 2004-05-21 | Lts Lohmann Therapie-Systeme Ag | Transmucosal pharmaceutical administration form |
JP2006513238A (en) * | 2002-12-19 | 2006-04-20 | ファルマシア・コーポレーション | Non-hygroscopic formulations containing hygroscopic drugs |
EP3473251A1 (en) * | 2002-12-20 | 2019-04-24 | NicoNovum AB | A nicotine-cellulose combination |
EP1803443A2 (en) * | 2002-12-20 | 2007-07-04 | NicoNovum AB | A method for the preparation of a nicotine-containing particulate material with a crystalline cellulose (in particular MCC) |
EP1803443B1 (en) * | 2002-12-20 | 2018-10-31 | NicoNovum AB | A nicotine-containing particulate material with a crystalline cellulose |
US9629832B2 (en) | 2002-12-20 | 2017-04-25 | Niconovum Usa, Inc. | Physically and chemically stable nicotine-containing particulate material |
WO2004069198A2 (en) * | 2003-02-04 | 2004-08-19 | Cephalon, Inc. | Sugar-free oral transmucosal solid dosage forms and uses thereof |
WO2004069198A3 (en) * | 2003-02-04 | 2004-10-07 | Cephalon Inc | Sugar-free oral transmucosal solid dosage forms and uses thereof |
JP2006516648A (en) * | 2003-02-04 | 2006-07-06 | セフアロン・インコーポレーテツド | Sugar-free oral transmucosal solid dosage forms and their use |
JP2006519187A (en) * | 2003-02-28 | 2006-08-24 | アルカベロ アクチェセルスカプ | Dosage form with saccharide matrix |
US8012505B2 (en) | 2003-02-28 | 2011-09-06 | Alk-Abello A/S | Dosage form having a saccharide matrix |
JP4688787B2 (en) * | 2003-02-28 | 2011-05-25 | アルカベロ アクチェセルスカプ | Dosage form with saccharide matrix |
US9023393B2 (en) | 2003-08-04 | 2015-05-05 | Bend Research, Inc. | Pharmaceutical compositions of adsorbates of amorphous drugs and lipophilic microphase-forming materials |
USRE47033E1 (en) | 2003-08-04 | 2018-09-11 | Bend Research, Inc. | Pharmaceutical compositions of adsorbates of amorphous drugs and lipophilic microphase-forming materials |
EP2308476A1 (en) * | 2003-11-19 | 2011-04-13 | Inkine Pharmaceutical Company, Inc. | Colonic purgative composition with soluble binding agent |
US8507009B2 (en) | 2003-11-19 | 2013-08-13 | Salix Pharmaceuticals, Inc. | Colonic purgative composition with soluble binding agent |
AU2015221520B2 (en) * | 2003-11-19 | 2017-06-08 | Salix Pharmaceuticals, Inc. | Colonic purgative composition with soluble binding agent |
AU2012202628B2 (en) * | 2003-11-19 | 2014-05-15 | Salix Pharmaceuticals, Inc. | Colonic purgative composition with soluble binding agent |
US9320721B2 (en) | 2004-09-01 | 2016-04-26 | Tesa Labtec Gmbh | Mucoadhesive patch with opposite ratios of nonionic and anionic hydrocolloids in adhesive and backing layer |
DE102005003387A1 (en) * | 2004-09-01 | 2006-03-02 | LABTEC Gesellschaft für technologische Forschung und Entwicklung mbH | Plaster for administering active agents through body orifices, comprises adhesive and backing layers, both made of nonionic and anionic hydrocolloids in reverse ratios |
WO2007009801A3 (en) * | 2005-07-20 | 2007-06-21 | Hexal Ag | Oral, quickly disintegrating film, which cannot be spit out, for a neuroleptic drug |
US8778393B2 (en) | 2006-01-06 | 2014-07-15 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
US8905964B2 (en) | 2006-01-06 | 2014-12-09 | Acelrx Pharmaceuticals, Inc. | Drug storage and dispensing devices and systems comprising the same |
US8865743B2 (en) | 2006-01-06 | 2014-10-21 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
US9289583B2 (en) | 2006-01-06 | 2016-03-22 | Acelrx Pharmaceuticals, Inc. | Methods for administering small volume oral transmucosal dosage forms using a dispensing device |
US10507180B2 (en) | 2006-01-06 | 2019-12-17 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
US8202535B2 (en) | 2006-01-06 | 2012-06-19 | Acelrx Pharmaceuticals, Inc. | Small-volume oral transmucosal dosage forms |
US10342762B2 (en) | 2006-01-06 | 2019-07-09 | Acelrx Pharmaceuticals, Inc. | Small-volume oral transmucosal dosage forms |
US8535714B2 (en) | 2006-01-06 | 2013-09-17 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
US10245228B2 (en) | 2006-01-06 | 2019-04-02 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
US8778394B2 (en) | 2006-01-06 | 2014-07-15 | Acelrx Pharmaceuticals, Inc. | Small-volume oral transmucosal dosage forms |
US8226978B2 (en) | 2006-01-06 | 2012-07-24 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
US9744129B2 (en) | 2006-01-06 | 2017-08-29 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
US9320710B2 (en) | 2006-01-06 | 2016-04-26 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
US8865211B2 (en) | 2006-01-06 | 2014-10-21 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
WO2007085498A1 (en) * | 2006-01-24 | 2007-08-02 | Bayer Schering Pharma Aktiengesellschaft | Pharmaceutical forms in film form for use in the mouth (wafers) |
US10219999B2 (en) | 2006-03-16 | 2019-03-05 | Niconovum Usa, Inc. | Snuff composition |
US11547660B2 (en) | 2006-03-16 | 2023-01-10 | Niconovum Usa, Inc. | Snuff composition |
US11129792B2 (en) | 2006-03-16 | 2021-09-28 | Modoral Brands Inc. | Snuff composition |
AU2007250588B2 (en) * | 2006-05-16 | 2013-01-31 | Mcneil Ab | Pharmaceutical product for intraoral delivery of nicotine comprising trometamol as buffering agent |
NO342308B1 (en) * | 2006-05-16 | 2018-05-07 | Mcneil Ab | Pharmaceutical product for intraoral delivery of nicotine including trometamol as buffer |
WO2007133141A1 (en) * | 2006-05-16 | 2007-11-22 | Mcneil Ab | Coated pharmaceutical product for intraoral delivery of nicotine comprising trometamol as buffering agent |
WO2007133140A1 (en) * | 2006-05-16 | 2007-11-22 | Mcneil Ab | Pharmaceutical product for intraoral delivery of nicotine comprising trometamol as buffering agent |
WO2008011194A2 (en) * | 2006-07-21 | 2008-01-24 | Biodelivery Sciences International, Inc. | Transmucosal delivery devices with enhanced uptake |
RU2504377C2 (en) * | 2006-07-21 | 2014-01-20 | БайоДеливери Сайенсиз Интэнэшнл, Инк. | Method for transmucosal drug delivery, agent for transmucosal drug delivery (versions) and method for pain management |
US9655843B2 (en) | 2006-07-21 | 2017-05-23 | Biodelivery Sciences International, Inc. | Transmucosal delivery devices with enhanced uptake |
WO2008011177A2 (en) * | 2006-07-21 | 2008-01-24 | Jsrnti, Llc | Medicinal delivery system and related methods |
WO2008011177A3 (en) * | 2006-07-21 | 2008-03-06 | Jsrnti Llc | Medicinal delivery system and related methods |
US10799449B2 (en) | 2006-07-21 | 2020-10-13 | Jsrnti, Llc | Medicinal delivery system and related methods |
NO344719B1 (en) * | 2006-07-21 | 2020-03-23 | Biodelivery Sciences Int Inc | TRANSMUCOSAL DELIVERY DEVICE WITH INCREASED RECORDING |
WO2008011194A3 (en) * | 2006-07-21 | 2008-05-15 | Biodelivery Sciences Int Inc | Transmucosal delivery devices with enhanced uptake |
EP3566692A1 (en) * | 2006-07-21 | 2019-11-13 | BioDelivery Sciences International, Inc. | Transmucosal delivery devices with enhanced uptake |
US9597288B2 (en) | 2006-07-21 | 2017-03-21 | Biodelivery Sciences International, Inc. | Transmucosal delivery devices with enhanced uptake |
EP3067044A1 (en) * | 2006-07-21 | 2016-09-14 | BioDelivery Sciences International, Inc. | Transmucosal delivery devices with enhanced uptake |
AU2007275581B2 (en) * | 2006-07-21 | 2011-09-08 | Biodelivery Sciences International, Inc. | Transmucosal delivery devices with enhanced uptake |
AU2007275565B2 (en) * | 2006-07-21 | 2012-07-19 | Jsrnti, Llc | Medicinal delivery system and related methods |
WO2008085765A3 (en) * | 2007-01-05 | 2008-11-27 | Acelrx Pharmaceuticals Inc | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
KR101545754B1 (en) | 2007-01-05 | 2015-08-19 | 아셀알엑스 파마슈티컬스 인코퍼레이티드 | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
CN101621994B (en) * | 2007-01-05 | 2016-06-01 | 阿塞尔Rx制药有限公司 | For treating a small amount of oral transmucosal dosage forms containing sufentanil of pain |
US9066847B2 (en) | 2007-01-05 | 2015-06-30 | Aceirx Pharmaceuticals, Inc. | Storage and dispensing devices for administration of oral transmucosal dosage forms |
US8945592B2 (en) | 2008-11-21 | 2015-02-03 | Acelrx Pharmaceuticals, Inc. | Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same |
US10821074B2 (en) | 2009-08-07 | 2020-11-03 | Aquestive Therapeutics, Inc. | Sublingual and buccal film compositions |
WO2011047143A1 (en) * | 2009-10-16 | 2011-04-21 | Acelrx Pharmaceuticals, Inc. | Compositions and methods for mild sedation, anxiolysis and analgesia in the procedural setting |
US10272607B2 (en) | 2010-10-22 | 2019-04-30 | Aquestive Therapeutics, Inc. | Manufacturing of small film strips |
US10940626B2 (en) | 2010-10-22 | 2021-03-09 | Aquestive Therapeutics, Inc. | Manufacturing of small film strips |
EP3939569A1 (en) | 2011-09-19 | 2022-01-19 | Orexo AB | New abuse-resistant pharmaceutical composition for the treatment of opioid dependence |
US9259421B2 (en) | 2011-09-19 | 2016-02-16 | Orexo Ab | Abuse-resistant pharmaceutical composition for the treatment of opioid dependence |
US9439900B2 (en) | 2011-09-19 | 2016-09-13 | Orexo Ab | Abuse-resistant pharmaceutical composition for the treatment of opioid dependence |
US10874661B2 (en) | 2011-09-19 | 2020-12-29 | Orexo Ab | Abuse-resistant pharmaceutical composition for the treatment of opioid dependence |
EP2915525A1 (en) | 2011-09-19 | 2015-09-09 | Orexo AB | Sublingual abuse-resistant tablets comprising buprenorphine and naloxone |
US8940330B2 (en) | 2011-09-19 | 2015-01-27 | Orexo Ab | Abuse-resistant pharmaceutical composition for the treatment of opioid dependence |
US10946010B2 (en) | 2011-09-19 | 2021-03-16 | Orexo Ab | Abuse-resistant pharmaceutical composition for the treatment of opioid dependence |
US11020387B2 (en) | 2011-09-19 | 2021-06-01 | Orexo Ab | Abuse-resistant pharmaceutical composition for the treatment of opioid dependence |
US11020388B2 (en) | 2011-09-19 | 2021-06-01 | Orexo Ab | Abuse-resistant pharmaceutical composition for the treatment of opioid dependence |
US11433066B2 (en) | 2011-09-19 | 2022-09-06 | Orexo Ab | Abuse-resistant pharmaceutical composition for the treatment of opioid dependence |
WO2013041851A1 (en) | 2011-09-19 | 2013-03-28 | Orexo Ab | New abuse-resistant pharmaceutical composition for the treatment of opioid dependence |
US9901539B2 (en) | 2011-12-21 | 2018-02-27 | Biodelivery Sciences International, Inc. | Transmucosal drug delivery devices for use in chronic pain relief |
US8815911B2 (en) | 2012-05-02 | 2014-08-26 | Orexo Ab | Alfentanil composition for the treatment of acute pain |
US9345698B2 (en) | 2012-05-02 | 2016-05-24 | Orexo Ab | Alfentanil composition for the treatment of acute pain |
US9782396B2 (en) | 2012-05-02 | 2017-10-10 | Orexo Ab | Alfentanil composition for the treatment of acute pain |
US11191737B2 (en) | 2016-05-05 | 2021-12-07 | Aquestive Therapeutics, Inc. | Enhanced delivery epinephrine compositions |
US11273131B2 (en) | 2016-05-05 | 2022-03-15 | Aquestive Therapeutics, Inc. | Pharmaceutical compositions with enhanced permeation |
US11737980B2 (en) | 2020-05-18 | 2023-08-29 | Orexo Ab | Pharmaceutical composition for drug delivery |
US11957647B2 (en) | 2021-11-25 | 2024-04-16 | Orexo Ab | Pharmaceutical composition comprising adrenaline |
WO2023187664A1 (en) * | 2022-03-30 | 2023-10-05 | Avaca Pharma Private Limited | A pharmaceutical composition for the treatment of immune system mediated diseases |
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ES2345870T5 (en) | 2018-02-12 |
MXPA02004235A (en) | 2004-04-21 |
AU1079701A (en) | 2001-05-08 |
JP4815084B2 (en) | 2011-11-16 |
CA2388610C (en) | 2007-08-21 |
ES2345870T3 (en) | 2010-10-05 |
EP1242013B2 (en) | 2017-12-06 |
ATE468845T2 (en) | 2010-06-15 |
EP1242013A1 (en) | 2002-09-25 |
HK1050313A1 (en) | 2003-06-20 |
CA2388610A1 (en) | 2001-05-03 |
EP1242013A4 (en) | 2005-06-15 |
JP2008201805A (en) | 2008-09-04 |
US6264981B1 (en) | 2001-07-24 |
JP2003512402A (en) | 2003-04-02 |
DE60044464D1 (en) | 2010-07-08 |
PT1242013E (en) | 2010-07-14 |
EP1242013B1 (en) | 2010-05-26 |
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