WO2001030419A2 - Disposable jet injector - Google Patents

Disposable jet injector Download PDF

Info

Publication number
WO2001030419A2
WO2001030419A2 PCT/GB2000/004152 GB0004152W WO0130419A2 WO 2001030419 A2 WO2001030419 A2 WO 2001030419A2 GB 0004152 W GB0004152 W GB 0004152W WO 0130419 A2 WO0130419 A2 WO 0130419A2
Authority
WO
WIPO (PCT)
Prior art keywords
jet injector
skin
nozzle
drug
delivery tube
Prior art date
Application number
PCT/GB2000/004152
Other languages
French (fr)
Other versions
WO2001030419A3 (en
Inventor
William Anthony Denne
Original Assignee
William Anthony Denne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9925483.1A external-priority patent/GB9925483D0/en
Priority claimed from GB0018056A external-priority patent/GB0018056D0/en
Priority claimed from GB0026310A external-priority patent/GB0026310D0/en
Application filed by William Anthony Denne filed Critical William Anthony Denne
Priority to AU11537/01A priority Critical patent/AU1153701A/en
Publication of WO2001030419A2 publication Critical patent/WO2001030419A2/en
Publication of WO2001030419A3 publication Critical patent/WO2001030419A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2006—Having specific accessories
    • A61M2005/2013—Having specific accessories triggering of discharging means by contact of injector with patient body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe
    • A61M2005/3118—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3128—Incorporating one-way valves, e.g. pressure-relief or non-return valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic

Definitions

  • Jet injectors have been in use for a long time. In the main, they require a significant amount of drive energy and deliver the dose so rapidly that it causes subcutaneous damage.
  • jet injector which is energised by pressing the device against the skin of the patient.
  • the pressure deforms a biaxially curved spring which may relax by reversibly buckling.
  • the fast moving relaxing spring may impact on a crimp in a drug delivery tube to generate a high pressure at the nozzle end.
  • the nozzle end of the drug delivery tube may be flared to form a small piston within a cylinder comprising the exit nozzle.
  • the exit nozzle may be in the form of a slit or non circular cross section.
  • the device may clip onto the ampoule in such a manner that removal will cause such damage that the system becomes inoperable.
  • a point contact of the nozzle on the skin may provide not only a good hydraulic seal but also generate a radially decreasing stress distribution within the soft tissue which will ensure that the drug is delivered to the full depth of the track.
  • the biaxially curved spring may be so formed as to provide a high mechanical advantage leverage system to reduce the forces applied to the skin of the patient.
  • Jet injectors have been in use for over half a century.
  • a high velocity droplet of fluid may pierce the skin and cut a track through the soft subcutaneous tissue.
  • a problem of the earlier injectors was that a jet of fluid fast enough to cut the toughest of skins would also penetrate too deeply, especially for drugs like insulin that must be deposited in the subcutaneous fat layer.
  • viscous forces attenuate it rapidly, so providing aggressive cutting at the dermis but ensuring controllable range. This effect may be enhanced by use of a planar jet from a slit like nozzle.
  • the main dose may be delivered manually from the ampoule in the usual manner, by depressing the piston. This may be done very slowly to minimise soft tissue damage.
  • a silicone non return valve may be fitted at the nozzle. This will inhibit back flow of material that might cause cross infection. It will also inhibit inflow of air due to thermal contraction of the fluid in the ampoule. Air in the delivery tube would inhibit the pump operation.
  • FIG. 1 An embodiment is shown in section in figure 1, with an enlarged view of the nozzle and valve for clarity.
  • an ampoule 1, with liquid drug, 2, rubber piston, 3, and rubber septum, 4, disposed in the usual configuration.
  • a drug delivery tube 5, which pierces the septum, 4.
  • This has a crimp, 6, midway along its length and a flare, 7 at the outlet end.
  • a injection moulded end cap, 8, which comprises, a cylinder, 9, and nozzle, 10.
  • the holder clips onto the ampoule as the drug delivery tube pierces the ampoule.
  • the holder, 14, and end cap, 8, may clip together or be the same moulding with a bayonet fitting to accept a somewhat rectangular shaped spring together with a flexible connection to permit compression of the spring.
  • the ampoule piston is advanced with the system held vertically to expel any air.
  • the end cap is then pressed against the skin of the patient which in turn flattens the biaxially curved spring. This then pops through the maximum strain configuration and accelerates toward impact with the drug delivery tube.
  • the impact is conducted along the tube to the flared end and the drug in the cylinder, 9, is subject to a very high pressure.
  • This high pressure ejects a droplet of drug through the nozzle, the elastomeric non return valve and the skin of the patient.
  • a pressure wave will also propagate up the delivery tube into the ampoule.
  • the constriction associated with the crimp will attenuate this.
  • the change in internal diameters of the crimp and ampoule will ensure that the pressures transmitted to the ampoule will be very small indeed.
  • the biaxially curved spring may be any desired shape. It may also be cut or formed in such a fashion that the end cap may exert a small force over a large distance to complete compression, so reducing the loading on the skin of the patient.
  • the zone around the hole may be formed in a conical shape to more effectively spread the load on impact. If the spring has a rectangular planform, it may be fitted to an integral holder, 14, and end cap, 8, assembly by insertion and rotation by 90°. In addition, the raising of the angled tips about the pressure point of the holder will provide a significant amount of travel, so reducing the load at the injector skin interface required to cock the device.
  • the holder 14 may have a number of radially disposed clips, as shown, engineered so that clipping to the ampoule takes the root of the cantilever clip close to its failure strain. It will be difficult to splay a number of such clips simultaneously to remove the injector. Any effort to splay them is likely to exceed the strength of the carefully engineered cantilevers, causing them to snap off. In this manner, the injector cannot be re-used. This will reduce the risk of infection and will also prevent use with a rival manufacturers ampoules.

Abstract

A jet injector is described which clips to the front of a standard drug ampoule (1) and is energised by pressing the assembly against the skin of the patient. The pressure deforms a biaxially curved spring (13) which buckles reversibly to impact the drug delivery tube (5), causing a high pressure transient. This generates a high speed droplet which cuts a track in the skin. The drug may then be administered with a syringe in the normal manner. An elastomeric non return valve (11) may be incorporated.

Description

DISPOSABLE JET INJECTOR
Jet injectors have been in use for a long time. In the main, they require a significant amount of drive energy and deliver the dose so rapidly that it causes subcutaneous damage.
According to the present invention there is jet injector which is energised by pressing the device against the skin of the patient. The pressure deforms a biaxially curved spring which may relax by reversibly buckling. The fast moving relaxing spring may impact on a crimp in a drug delivery tube to generate a high pressure at the nozzle end. The nozzle end of the drug delivery tube may be flared to form a small piston within a cylinder comprising the exit nozzle. The exit nozzle may be in the form of a slit or non circular cross section. There may be an elastomeric non return valve to prevent ingress of infection or air. The device may clip onto the ampoule in such a manner that removal will cause such damage that the system becomes inoperable. A point contact of the nozzle on the skin may provide not only a good hydraulic seal but also generate a radially decreasing stress distribution within the soft tissue which will ensure that the drug is delivered to the full depth of the track. The biaxially curved spring may be so formed as to provide a high mechanical advantage leverage system to reduce the forces applied to the skin of the patient.
Jet injectors have been in use for over half a century. A high velocity droplet of fluid may pierce the skin and cut a track through the soft subcutaneous tissue. A problem of the earlier injectors was that a jet of fluid fast enough to cut the toughest of skins would also penetrate too deeply, especially for drugs like insulin that must be deposited in the subcutaneous fat layer. By using a single droplet, viscous forces attenuate it rapidly, so providing aggressive cutting at the dermis but ensuring controllable range. This effect may be enhanced by use of a planar jet from a slit like nozzle.
Most jet injectors use a significant power source. Compressed gas is a favourite, though springs and even explosive charges have been used. In the present device, a spring is used, though the cutting drop is of such a small volume that just pressing the device against the skin is sufficient to cock and fire the device. There is a biaxially curved spring. This is compressed by applying a couple at the edge. The stress in the spring increases until is almost planar at which point it buckles reversibly and turns inside out. The centre of the spring is travelling very fast at the minimum energy configuration. If there is a hole through the centre of the spring such that it may travel along the drug delivery tube, it may be arranged that the centre of the spring may impact on a crimp in the drug delivery tube creating a very high transient load. This load will be transmitted to the end of the drug delivery tube where it may actuate a micro piston to eject a fast droplet of drug.
The main dose may be delivered manually from the ampoule in the usual manner, by depressing the piston. This may be done very slowly to minimise soft tissue damage. A silicone non return valve may be fitted at the nozzle. This will inhibit back flow of material that might cause cross infection. It will also inhibit inflow of air due to thermal contraction of the fluid in the ampoule. Air in the delivery tube would inhibit the pump operation.
An embodiment is shown in section in figure 1, with an enlarged view of the nozzle and valve for clarity. There is an ampoule, 1, with liquid drug, 2, rubber piston, 3, and rubber septum, 4, disposed in the usual configuration. There is a drug delivery tube, 5, which pierces the septum, 4. This has a crimp, 6, midway along its length and a flare, 7 at the outlet end. There is a injection moulded end cap, 8, which comprises, a cylinder, 9, and nozzle, 10. There is also an elastomeric non return valve, 11, on the outer surface, 12. There is a biaxially curved stainless steel spring, 13, and an injection moulded holder, 14. The holder clips onto the ampoule as the drug delivery tube pierces the ampoule. The holder, 14, and end cap, 8, may clip together or be the same moulding with a bayonet fitting to accept a somewhat rectangular shaped spring together with a flexible connection to permit compression of the spring.
In operation, the ampoule piston is advanced with the system held vertically to expel any air. The end cap is then pressed against the skin of the patient which in turn flattens the biaxially curved spring. This then pops through the maximum strain configuration and accelerates toward impact with the drug delivery tube. The impact is conducted along the tube to the flared end and the drug in the cylinder, 9, is subject to a very high pressure. This high pressure ejects a droplet of drug through the nozzle, the elastomeric non return valve and the skin of the patient. A pressure wave will also propagate up the delivery tube into the ampoule. The constriction associated with the crimp will attenuate this. The change in internal diameters of the crimp and ampoule will ensure that the pressures transmitted to the ampoule will be very small indeed.
There will be a click indicating that the spring has fired and produced a track. The piston in the ampoule may then be depressed to deliver the drug. In the unlikely event of an unsuccessful pierce, it will be impossible to depress the plunger, the hydraulic seal of the nozzle to the skin being good to several atmospheres. Should the pressure be inadvertently removed, the spring will click back to its original position indicating that the injection is over. The balance of the injection may be repeated at a new site.
The biaxially curved spring may be any desired shape. It may also be cut or formed in such a fashion that the end cap may exert a small force over a large distance to complete compression, so reducing the loading on the skin of the patient. The zone around the hole may be formed in a conical shape to more effectively spread the load on impact. If the spring has a rectangular planform, it may be fitted to an integral holder, 14, and end cap, 8, assembly by insertion and rotation by 90°. In addition, the raising of the angled tips about the pressure point of the holder will provide a significant amount of travel, so reducing the load at the injector skin interface required to cock the device.
The holder 14 may have a number of radially disposed clips, as shown, engineered so that clipping to the ampoule takes the root of the cantilever clip close to its failure strain. It will be difficult to splay a number of such clips simultaneously to remove the injector. Any effort to splay them is likely to exceed the strength of the carefully engineered cantilevers, causing them to snap off. In this manner, the injector cannot be re-used. This will reduce the risk of infection and will also prevent use with a rival manufacturers ampoules.

Claims

1. A jet injector which is energised by pressing the device against the skin of the patient.
2. A jet injector powered by a biaxially curved spring which compressed by flattening with a couple at the periphery and in which the compression energy is converted into kinetic energy by reversibly buckling past the flattened configuration.
3. A jet injector according to the claims 1 and 2 in which the fast moving biaxially curved spring may impact on a crimp in a drug delivery tube to generate a transient high pressure.
4. A jet injector according to claims 1 to 3, in which the nozzle end of the drug delivery tube may be flared to form a small piston within a cylinder which comprises the exit nozzle.
5. A jet injector in which the exit nozzle may be in the form of a slit or non circular cross section.
6. A jet injector according to the claims 1 to 5 which incorporates an elastomeric non return valve to prevent ingress of infection or air.
7. A jet injector according to claims 1 to 6, which may clip onto an ampoule in such a manner that removal will cause such damage that the system becomes inoperable.
8. A jet injector that exerts a point contact of the nozzle on the skin to provide both a good hydraulic seal and also a radially decreasing stress distribution within the underlying soft tissue which will ensure that the drug is delivered to the full depth of the track.
9. A jet injector that comprises a biaxially curved spring formed to provide a high mechanical advantage leverage system which permits cocking with a small force operating through a large distance.
PCT/GB2000/004152 1999-10-28 2000-10-30 Disposable jet injector WO2001030419A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU11537/01A AU1153701A (en) 1999-10-28 2000-10-30 Disposable jet injector

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GBGB9925483.1A GB9925483D0 (en) 1999-10-28 1999-10-28 Low energy injector
GB9925483.1 1999-10-28
GB0018056.2 2000-07-24
GB0018056A GB0018056D0 (en) 1999-10-28 2000-07-24 Impact jet injector
GB0026310A GB0026310D0 (en) 1999-10-28 2000-10-27 Disposable jet injector
GB0026310.3 2000-10-27

Publications (2)

Publication Number Publication Date
WO2001030419A2 true WO2001030419A2 (en) 2001-05-03
WO2001030419A3 WO2001030419A3 (en) 2001-09-20

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Family Applications (1)

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PCT/GB2000/004152 WO2001030419A2 (en) 1999-10-28 2000-10-30 Disposable jet injector

Country Status (2)

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AU (1) AU1153701A (en)
WO (1) WO2001030419A2 (en)

Cited By (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003000320A1 (en) * 2001-06-20 2003-01-03 William Denne A low cost disposable jet injector
WO2004039438A1 (en) * 2002-11-01 2004-05-13 Novo Nordisk A/S Jet injector with a bi-stable spring
FR2853837A1 (en) * 2003-04-16 2004-10-22 Crossject Medication injector with or without needle has tube of active liquid connected to nozzle by projections with inclined surfaces and shoulders
WO2005070482A1 (en) * 2004-01-26 2005-08-04 Novo Nordisk A/S Impulse chamber for jet delivery device
WO2007094833A1 (en) * 2006-02-14 2007-08-23 Battelle Memorial Institute Accurate metering system
US7648494B2 (en) 2004-03-26 2010-01-19 Unomedical A/S Infusion set and injector device for infusion set
US7654484B2 (en) 2002-09-02 2010-02-02 Unomedical A/S Apparatus for and a method of adjusting the length of an infusion tube
US7802824B2 (en) 2002-11-26 2010-09-28 Unomedical A/S Connecting piece for a tubing
US7867200B2 (en) 2004-12-10 2011-01-11 Unomedical A/S Inserter
US7985199B2 (en) 2005-03-17 2011-07-26 Unomedical A/S Gateway system
US8012126B2 (en) 2006-10-31 2011-09-06 Unomedical A/S Infusion set
US8062250B2 (en) 2004-08-10 2011-11-22 Unomedical A/S Cannula device
USD655807S1 (en) 2005-12-09 2012-03-13 Unomedical A/S Medical device
US8152771B2 (en) 2001-09-27 2012-04-10 Unomedical A/S Injector device for placing a subcutaneous infusion set
US8246588B2 (en) 2007-07-18 2012-08-21 Unomedical A/S Insertion device with pivoting action
US8303549B2 (en) 2005-12-23 2012-11-06 Unomedical A/S Injection device
US8430850B2 (en) 2007-07-03 2013-04-30 Unomedical A/S Inserter having bistable equilibrium states
US8439838B2 (en) 2006-06-07 2013-05-14 Unomedical A/S Inserter for transcutaneous sensor
US8486003B2 (en) 2007-07-10 2013-07-16 Unomedical A/S Inserter having two springs
US8562567B2 (en) 2009-07-30 2013-10-22 Unomedical A/S Inserter device with horizontal moving part
US8608684B2 (en) 2003-11-27 2013-12-17 Novo Nordisk A/S Impulse chamber for jet delivery device
US8790311B2 (en) 2006-06-09 2014-07-29 Unomedical A/S Mounting pad
CN104189969A (en) * 2014-05-24 2014-12-10 戎静华 Automatic liquid-stopping infusion apparatus with novel exhaust liquid-storage tube
US8945057B2 (en) 2006-08-02 2015-02-03 Unomedical A/S Cannula and delivery device
US9084566B2 (en) 2006-07-07 2015-07-21 Proteus Digital Health, Inc. Smart parenteral administration system
US9186480B2 (en) 2007-06-20 2015-11-17 Unomedical A/S Apparatus for making a catheter
US9211379B2 (en) 2006-02-28 2015-12-15 Unomedical A/S Inserter for infusion part and infusion part provided with needle protector
US9254373B2 (en) 2008-12-22 2016-02-09 Unomedical A/S Medical device comprising adhesive pad
US9415159B2 (en) 2010-03-30 2016-08-16 Unomedical A/S Medical device
US9440051B2 (en) 2011-10-27 2016-09-13 Unomedical A/S Inserter for a multiplicity of subcutaneous parts
US9533092B2 (en) 2009-08-07 2017-01-03 Unomedical A/S Base part for a medication delivery device
US9566384B2 (en) 2008-02-20 2017-02-14 Unomedical A/S Insertion device with horizontally moving part
US9724127B2 (en) 2010-09-27 2017-08-08 Unomedical A/S Insertion system and insertion kit
US10369277B2 (en) 2005-09-12 2019-08-06 Unomedical A/S Invisible needle
US10376218B2 (en) 2010-02-01 2019-08-13 Proteus Digital Health, Inc. Data gathering system
CN110248689A (en) * 2016-12-07 2019-09-17 赛诺菲-安万特德国有限公司 Cap for injection device
US10898643B2 (en) 2008-02-13 2021-01-26 Unomedical A/S Sealing between a cannula part and a fluid path
US11020526B2 (en) 2010-10-04 2021-06-01 Unomedical A/S Sprinkler cannula
US11110261B2 (en) 2011-10-19 2021-09-07 Unomedical A/S Infusion tube system and method for manufacture
US11197689B2 (en) 2011-10-05 2021-12-14 Unomedical A/S Inserter for simultaneous insertion of multiple transcutaneous parts

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EP2531096A4 (en) 2010-02-01 2013-09-11 Proteus Digital Health Inc Two-wrist data gathering system

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Cited By (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003000320A1 (en) * 2001-06-20 2003-01-03 William Denne A low cost disposable jet injector
US8152771B2 (en) 2001-09-27 2012-04-10 Unomedical A/S Injector device for placing a subcutaneous infusion set
US8172805B2 (en) 2001-09-27 2012-05-08 Unomedical A/S Injector device for placing a subcutaneous infusion set
US8162892B2 (en) 2001-09-27 2012-04-24 Unomedical A/S Injector device for placing a subcutaneous infusion set
US7654484B2 (en) 2002-09-02 2010-02-02 Unomedical A/S Apparatus for and a method of adjusting the length of an infusion tube
WO2004039438A1 (en) * 2002-11-01 2004-05-13 Novo Nordisk A/S Jet injector with a bi-stable spring
US7802824B2 (en) 2002-11-26 2010-09-28 Unomedical A/S Connecting piece for a tubing
US7559920B2 (en) 2003-04-16 2009-07-14 Crossject Device for connecting an active substance container to an injection nozzle in a device used to inject said active substance
FR2853837A1 (en) * 2003-04-16 2004-10-22 Crossject Medication injector with or without needle has tube of active liquid connected to nozzle by projections with inclined surfaces and shoulders
WO2004093947A1 (en) * 2003-04-16 2004-11-04 Crossject Device for connecting an active substance container to an injection nozzle in a device used to inject said active substance
US8608684B2 (en) 2003-11-27 2013-12-17 Novo Nordisk A/S Impulse chamber for jet delivery device
WO2005070482A1 (en) * 2004-01-26 2005-08-04 Novo Nordisk A/S Impulse chamber for jet delivery device
US8221355B2 (en) 2004-03-26 2012-07-17 Unomedical A/S Injection device for infusion set
US8287516B2 (en) 2004-03-26 2012-10-16 Unomedical A/S Infusion set
US7648494B2 (en) 2004-03-26 2010-01-19 Unomedical A/S Infusion set and injector device for infusion set
US8062250B2 (en) 2004-08-10 2011-11-22 Unomedical A/S Cannula device
US7867200B2 (en) 2004-12-10 2011-01-11 Unomedical A/S Inserter
US7867199B2 (en) 2004-12-10 2011-01-11 Unomedical A/S Inserter
US7985199B2 (en) 2005-03-17 2011-07-26 Unomedical A/S Gateway system
US10369277B2 (en) 2005-09-12 2019-08-06 Unomedical A/S Invisible needle
USD682415S1 (en) 2005-12-09 2013-05-14 Unomedical A/S Medical device
USD655807S1 (en) 2005-12-09 2012-03-13 Unomedical A/S Medical device
US8303549B2 (en) 2005-12-23 2012-11-06 Unomedical A/S Injection device
US9278173B2 (en) 2005-12-23 2016-03-08 Unomedical A/S Device for administration
WO2007094833A1 (en) * 2006-02-14 2007-08-23 Battelle Memorial Institute Accurate metering system
US9211379B2 (en) 2006-02-28 2015-12-15 Unomedical A/S Inserter for infusion part and infusion part provided with needle protector
US8439838B2 (en) 2006-06-07 2013-05-14 Unomedical A/S Inserter for transcutaneous sensor
US8790311B2 (en) 2006-06-09 2014-07-29 Unomedical A/S Mounting pad
US9084566B2 (en) 2006-07-07 2015-07-21 Proteus Digital Health, Inc. Smart parenteral administration system
US8945057B2 (en) 2006-08-02 2015-02-03 Unomedical A/S Cannula and delivery device
US8012126B2 (en) 2006-10-31 2011-09-06 Unomedical A/S Infusion set
US9320869B2 (en) 2007-06-20 2016-04-26 Unomedical A/S Apparatus for making a catheter
US9186480B2 (en) 2007-06-20 2015-11-17 Unomedical A/S Apparatus for making a catheter
US8430850B2 (en) 2007-07-03 2013-04-30 Unomedical A/S Inserter having bistable equilibrium states
US8486003B2 (en) 2007-07-10 2013-07-16 Unomedical A/S Inserter having two springs
US8246588B2 (en) 2007-07-18 2012-08-21 Unomedical A/S Insertion device with pivoting action
US10898643B2 (en) 2008-02-13 2021-01-26 Unomedical A/S Sealing between a cannula part and a fluid path
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AU1153701A (en) 2001-05-08

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