WO2001032232A3 - Method of forming micropores in skin - Google Patents

Method of forming micropores in skin Download PDF

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Publication number
WO2001032232A3
WO2001032232A3 PCT/US2000/041754 US0041754W WO0132232A3 WO 2001032232 A3 WO2001032232 A3 WO 2001032232A3 US 0041754 W US0041754 W US 0041754W WO 0132232 A3 WO0132232 A3 WO 0132232A3
Authority
WO
WIPO (PCT)
Prior art keywords
stratum corneum
surface area
pores
aqueous material
sonic
Prior art date
Application number
PCT/US2000/041754
Other languages
French (fr)
Other versions
WO2001032232A2 (en
Inventor
Ludwig J Weimann
Junru Wu
Original Assignee
Univ Vermont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Vermont filed Critical Univ Vermont
Priority to JP2001534436A priority Critical patent/JP2004520852A/en
Priority to AU37912/01A priority patent/AU3791201A/en
Priority to CA002389626A priority patent/CA2389626A1/en
Publication of WO2001032232A2 publication Critical patent/WO2001032232A2/en
Publication of WO2001032232A3 publication Critical patent/WO2001032232A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis

Abstract

A method of forming pores (600) in the stratum corneum (210) includes applying an aqueous material (123) to a surface area of the stratum corneum followed by the application of sonic and/or ultrasonic radiation (112) to said aqueous material wherein said sonic and/or ultrasonic radiation has a frequency in the range of 10KHz and 5 MHz and is applied at an intensity, for a period of time and at a distance from said surface area of the stratum corneum effective to generate cavitation bubbles (500) on said surface area of the stratum corneum, wherein said cavitation bubbles collapse and transfer their energy into the stratum corneum causing the formation of pores. Large size molecules ( > 500Da) dissolved in the aqueous material can transfer through these pores and across the stratum corneum and reach the blood vessels at flow rates suitable for therapeutic applications.
PCT/US2000/041754 1999-11-02 2000-11-01 Method of forming micropores in skin WO2001032232A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2001534436A JP2004520852A (en) 1999-11-02 2000-11-01 How to form micropores in the skin
AU37912/01A AU3791201A (en) 1999-11-02 2000-11-01 Method of forming micropores in skin
CA002389626A CA2389626A1 (en) 1999-11-02 2000-11-01 Method of forming micropores in skin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16314699P 1999-11-02 1999-11-02
US60/163,146 1999-11-02

Publications (2)

Publication Number Publication Date
WO2001032232A2 WO2001032232A2 (en) 2001-05-10
WO2001032232A3 true WO2001032232A3 (en) 2002-08-01

Family

ID=22588686

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/041754 WO2001032232A2 (en) 1999-11-02 2000-11-01 Method of forming micropores in skin

Country Status (4)

Country Link
JP (1) JP2004520852A (en)
AU (1) AU3791201A (en)
CA (1) CA2389626A1 (en)
WO (1) WO2001032232A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7923897B2 (en) 2005-07-04 2011-04-12 Sonopore, Ltd. Sonic fine-hole forming apparatus
GB0518273D0 (en) * 2005-09-08 2005-10-19 Univ Dundee Apparatus and method for sonoporation
KR102066046B1 (en) 2017-08-25 2020-01-14 주식회사 루트로닉 An skin treatment apparatus using rf energy and a method for skin treatment using that
US11648312B2 (en) * 2017-12-22 2023-05-16 Pierangela Giustetto System for inducing sonoporation of a drug into cancer cells and method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4767402A (en) * 1986-07-08 1988-08-30 Massachusetts Institute Of Technology Ultrasound enhancement of transdermal drug delivery
US5421816A (en) * 1992-10-14 1995-06-06 Endodermic Medical Technologies Company Ultrasonic transdermal drug delivery system

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4767402A (en) * 1986-07-08 1988-08-30 Massachusetts Institute Of Technology Ultrasound enhancement of transdermal drug delivery
US5421816A (en) * 1992-10-14 1995-06-06 Endodermic Medical Technologies Company Ultrasonic transdermal drug delivery system

Also Published As

Publication number Publication date
WO2001032232A2 (en) 2001-05-10
AU3791201A (en) 2001-05-14
CA2389626A1 (en) 2001-05-10
JP2004520852A (en) 2004-07-15

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