WO2001034550A3 - 15-hydroxyeicosatetraenoic acid analogs with enhanced metabolic stability and methods of their use in treating dry eye disorders - Google Patents

15-hydroxyeicosatetraenoic acid analogs with enhanced metabolic stability and methods of their use in treating dry eye disorders Download PDF

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Publication number
WO2001034550A3
WO2001034550A3 PCT/US2000/029234 US0029234W WO0134550A3 WO 2001034550 A3 WO2001034550 A3 WO 2001034550A3 US 0029234 W US0029234 W US 0029234W WO 0134550 A3 WO0134550 A3 WO 0134550A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
dry eye
metabolic stability
treating dry
acid analogs
Prior art date
Application number
PCT/US2000/029234
Other languages
French (fr)
Other versions
WO2001034550A2 (en
Inventor
David B Belanger
Original Assignee
Alcon Universal Ltd
David B Belanger
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Universal Ltd, David B Belanger filed Critical Alcon Universal Ltd
Priority to AU80314/00A priority Critical patent/AU8031400A/en
Publication of WO2001034550A2 publication Critical patent/WO2001034550A2/en
Publication of WO2001034550A3 publication Critical patent/WO2001034550A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/353—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups

Abstract

15-HETE derivatives with enhanced metabolic stability and methods of their use for treating dry eye are disclosed.
PCT/US2000/029234 1999-11-09 2000-10-23 15-hydroxyeicosatetraenoic acid analogs with enhanced metabolic stability and methods of their use in treating dry eye disorders WO2001034550A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU80314/00A AU8031400A (en) 1999-11-09 2000-10-23 15-hydroxyeicosatetraenoic acid analogs with enhanced metabolic stability and methods of their use in treating dry eye disorders

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16437499P 1999-11-09 1999-11-09
US60/164,374 1999-11-09

Publications (2)

Publication Number Publication Date
WO2001034550A2 WO2001034550A2 (en) 2001-05-17
WO2001034550A3 true WO2001034550A3 (en) 2001-12-13

Family

ID=22594202

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/029234 WO2001034550A2 (en) 1999-11-09 2000-10-23 15-hydroxyeicosatetraenoic acid analogs with enhanced metabolic stability and methods of their use in treating dry eye disorders

Country Status (3)

Country Link
US (2) US6320062B1 (en)
AU (1) AU8031400A (en)
WO (1) WO2001034550A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003030894A1 (en) * 2001-10-11 2003-04-17 Alcon, Inc. Methods for treating dry eye
WO2003105831A1 (en) * 2002-06-14 2003-12-24 Alcon, Inc. Use of hydroxyeicosatetraenoic acid compounds to treat ophthalmic inflammatory disorders
US20030236284A1 (en) * 2002-06-14 2003-12-25 Alcon, Inc. Use of hydroxyeicosatetraenoic acid compounds to treat vaginal dryness
US20040002514A1 (en) * 2002-06-14 2004-01-01 Alcon, Inc. Topical use of hydroxyeicosatetraenoic acid compounds to treat psoriasis
JP2006502183A (en) * 2002-09-20 2006-01-19 アルコン，インコーポレイテッド Use of cytokine synthesis inhibitors for the treatment of dry eye disorders
US9289494B2 (en) * 2013-11-20 2016-03-22 RestorTears, LLC Method of treating ocular disorders with compounds found in Harderian gland secretions

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999059964A1 (en) * 1998-05-15 1999-11-25 University Of Vermont Novel analogs of 16-hydroxyeicosatetraenoic acid

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3991759A (en) 1975-10-28 1976-11-16 Alza Corporation Method and therapeutic system for treating aqueous deficient dry eye
US4131651A (en) 1977-10-25 1978-12-26 Barnes-Hind Pharmaceuticals, Inc. Treatment of dry eye
US4409205A (en) 1979-03-05 1983-10-11 Cooper Laboratories, Inc. Ophthalmic solution
US4370325A (en) 1979-03-30 1983-01-25 Dermik Laboratories Pharmaceutical compositions and method of treatment
AU546872B2 (en) 1982-06-16 1985-09-26 Unilever Plc Skin treatment compositions containing a fatty acid or ester
US4421748A (en) 1982-07-13 1983-12-20 Trager Seymour F Artificial tear aid
GB8319073D0 (en) 1983-07-14 1983-08-17 Efamol Ltd Fatty acid compositions
US4868154A (en) 1986-02-19 1989-09-19 Eye Research Institute Of Retina Foundation Stimulation of tear secretion with melanocyte stimulating hormones
US4753945A (en) 1986-02-19 1988-06-28 Eye Research Institute Of Retina Foundation Stimulation of tear secretion with phosphodiesterase inhibitors
US4744980A (en) 1986-04-28 1988-05-17 Holly Frank J Ophthalmic solution for treatment of dry eye syndrome
US4883658A (en) 1986-04-28 1989-11-28 Holly Frank J Ophthalmic solution for treatment of dry-eye syndrome
US4804539A (en) 1986-07-28 1989-02-14 Liposome Technology, Inc. Ophthalmic liposomes
US4818537A (en) 1986-10-21 1989-04-04 Liposome Technology, Inc. Liposome composition for treating dry eye
US4966773A (en) 1986-11-25 1990-10-30 Alcon Laboratories, Inc. Topical ophthalmic compositions containing microfine retinoid particles
US5278151A (en) 1987-04-02 1994-01-11 Ocular Research Of Boston, Inc. Dry eye treatment solution
US4914088A (en) 1987-04-02 1990-04-03 Thomas Glonek Dry eye treatment solution and method
US4921644A (en) 1988-02-29 1990-05-01 Technology Unlimited, Inc. Mucin directed lipsome
US4906467A (en) 1988-03-24 1990-03-06 New York Medical College Novel, long-duration treatment for glaucoma
US4923700A (en) 1988-06-03 1990-05-08 Kaufman Herbert E Artificial tear suspension
US5064655A (en) 1989-02-24 1991-11-12 Liposome Technology, Inc. Liposome gel composition and method
US5075104A (en) 1989-03-31 1991-12-24 Alcon Laboratories, Inc. Ophthalmic carboxy vinyl polymer gel for dry eye syndrome
US5174988A (en) 1989-07-27 1992-12-29 Scientific Development & Research, Inc. Phospholipid delivery system
AU655919B2 (en) 1990-02-22 1995-01-19 Macnaught Pty Limited Artificial tears
US5041434A (en) 1991-08-17 1991-08-20 Virginia Lubkin Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application
EP0459148B1 (en) 1990-05-29 1996-01-03 Ocular Research Of Boston Inc. Dry eye treatment composition
ZA912797B (en) 1990-05-29 1992-12-30 Boston Ocular Res Dry eye treatment process and solution
US5102670A (en) 1990-09-14 1992-04-07 Abraham Nader G Method for treating eye disorders by reducing 12(r)-hydroxyeicosatetraenoic acid and 12(r)-dihydroxyeicosatrienoic acid levels
DE69212850T2 (en) 1991-01-15 1997-03-06 Alcon Lab Inc Use of carrageenan in topical ophthalmic compositions
ZA927277B (en) 1991-10-02 1993-05-19 Boston Ocular Res Dry eye treatment process and solution.
EP0546728A3 (en) 1991-12-13 1993-09-08 Alcon Laboratories Inc Physiological tear compositions and methods for their preparation
ES2139005T3 (en) 1992-04-21 2000-02-01 Schepens Eye Res Inst EYE THERAPY WITH ANDROGEN IN SJOGREN'S SYNDROME.
US5290572A (en) 1992-08-06 1994-03-01 Deo Corporation Opthalmic composition for treating dry eye
US5358706A (en) 1992-09-30 1994-10-25 Union Carbide Chemicals & Plastics Technology Corporation Muco-adhesive polymers
US5455265A (en) 1993-02-11 1995-10-03 Allergan, Inc. Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors
US5389383A (en) 1993-06-18 1995-02-14 Allergan, Inc. Method for treating hypoxia-associated ocular complications
US5696166A (en) 1995-10-31 1997-12-09 Yanni; John M. Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders
US6087325A (en) 1996-10-15 2000-07-11 The Liposome Company, Inc. Peptide-lipid conjugates
US5800807A (en) 1997-01-29 1998-09-01 Bausch & Lomb Incorporated Ophthalmic compositions including glycerin and propylene glycol

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999059964A1 (en) * 1998-05-15 1999-11-25 University Of Vermont Novel analogs of 16-hydroxyeicosatetraenoic acid

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
A.S. SUBBARAMAN ET AL: "A facile racemic synthesis of eicosane-1,16-diol, an aglycone of a marine natural product forbesin", INDIAN JOURNAL OF CHEMISTRY, vol. 31B, no. 4, 1992, pages 262 - 263, XP001002142 *
J. A. FINDLAY ET AL: "Forbesin: A novel sulfated glycolipid from the starfish Asterias Forbesi", JOURNAL OF NATURAL PRODUCTS, vol. 53, no. 4, 1990, pages 1015 - 1018, XP001002172 *
J. DAN AND S. THAKUR: "Constituent acids of Cucumis sativus Fruit Cutin", ASIAN JOURNAL OF CHEMISTRY, vol. 7, no. 2, 1995, pages 381 - 388, XP001002140 *
L. MORRIS ET AL: "Chromatographic behaviour of isomeric long-chain aliphatic compounds", JOURNAL OF CHROMATOGRAPHY, vol. 33, no. 3-4, 1968, pages 471 - 479, XP001002120 *

Also Published As

Publication number Publication date
US6320062B1 (en) 2001-11-20
US6348496B1 (en) 2002-02-19
WO2001034550A2 (en) 2001-05-17
AU8031400A (en) 2001-06-06

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