WO2001034764A3 - Apparatus and methods for positioning and analyzing biological membranous objects - Google Patents

Apparatus and methods for positioning and analyzing biological membranous objects Download PDF

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Publication number
WO2001034764A3
WO2001034764A3 PCT/IB2000/001625 IB0001625W WO0134764A3 WO 2001034764 A3 WO2001034764 A3 WO 2001034764A3 IB 0001625 W IB0001625 W IB 0001625W WO 0134764 A3 WO0134764 A3 WO 0134764A3
Authority
WO
WIPO (PCT)
Prior art keywords
zone
positioning
fluid
objects
methods
Prior art date
Application number
PCT/IB2000/001625
Other languages
French (fr)
Other versions
WO2001034764A2 (en
Inventor
Christian Schmidt
Original Assignee
Cytion S A
Christian Schmidt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytion S A, Christian Schmidt filed Critical Cytion S A
Priority to AU10474/01A priority Critical patent/AU1047401A/en
Publication of WO2001034764A2 publication Critical patent/WO2001034764A2/en
Publication of WO2001034764A3 publication Critical patent/WO2001034764A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48728—Investigating individual cells, e.g. by patch clamp, voltage clamp
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates

Abstract

Apparatus for positioning a cell or other biological membranous object within a confined compatible fluid compartment of fixed geometry has a surface that has a first zone repulsive to the fluid enclosing a second zone that is attractive to the fluid. The first zone controls the geometry and position of the fluid compartment on the second zone. The second zone has an area of less than about 500 νm2. A method for positioning a membranous object in the second zone on the carrier is also provided. The membranous object is first immersed into the liquid in a volume of no greater than about 100 nl. The liquid having the object immersed therein is loaded onto the surface so that the fluid is restricted to the second zone and the object comes into contact with the second zone.
PCT/IB2000/001625 1999-11-08 2000-11-08 Apparatus and methods for positioning and analyzing biological membranous objects WO2001034764A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU10474/01A AU1047401A (en) 1999-11-08 2000-11-08 Apparatus and methods for positioning and analyzing biological membranous objects

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16412899P 1999-11-08 1999-11-08
US60/164,128 1999-11-08

Publications (2)

Publication Number Publication Date
WO2001034764A2 WO2001034764A2 (en) 2001-05-17
WO2001034764A3 true WO2001034764A3 (en) 2001-12-27

Family

ID=22593096

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2000/001625 WO2001034764A2 (en) 1999-11-08 2000-11-08 Apparatus and methods for positioning and analyzing biological membranous objects

Country Status (2)

Country Link
AU (1) AU1047401A (en)
WO (1) WO2001034764A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9146221B2 (en) 2001-03-24 2015-09-29 Aviva Biosciences Corporation High-density ion transport measurement biochip devices and methods

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002024862A2 (en) * 2000-09-19 2002-03-28 Cytion S.A. Sample positioning and analysis system
CA2441366A1 (en) 2001-03-24 2002-10-03 Aviva Biosciences Corporation Biochips including ion transport detecting structures and methods of use
BR0209957A (en) * 2001-05-21 2004-03-30 Hoffmann La Roche Compound, process for preparing a compound, pharmaceutical composition comprising a compound, use of such compound and process for the treatment and prophylaxis of arthritis, diabetes, eating disorders and obesity
EP1397677A1 (en) * 2001-06-20 2004-03-17 Sophion Bioscience A/S An apparatus and method for determining and/or monitoring electrophysiological properties of ion channels
EP1501924A4 (en) 2002-05-04 2006-05-24 Aviva Biosciences Corp Apparatus including ion transport detecting structures and methods of use
US7810380B2 (en) 2003-03-25 2010-10-12 Tearlab Research, Inc. Systems and methods for collecting tear film and measuring tear film osmolarity
DE102013007295B4 (en) * 2013-04-26 2015-06-25 Universität Rostock Electrophysiological measuring arrangement and electrophysiological measuring method
BR112017005121A2 (en) 2014-09-23 2018-07-31 Tearlab Res Inc systems and methods for integrating microfluidic tear collection and lateral flow analysis of analytes of interest.

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5234566A (en) * 1988-08-18 1993-08-10 Australian Membrane And Biotechnology Research Institute Ltd. Sensitivity and selectivity of ion channel biosensor membranes
DE19628928A1 (en) * 1996-07-18 1998-01-22 Basf Ag Solid supports for analytical measurement processes, a process for their production and their use
WO1998047003A1 (en) * 1997-04-17 1998-10-22 Cytonix Corporation An analytical assembly for polymerase chain reaction
WO1998058248A1 (en) * 1997-06-14 1998-12-23 Coventry University Biosensor comprising a lipid membrane containing gated ion channels
WO1999031503A1 (en) * 1997-12-17 1999-06-24 Horst Vogel Positioning and electrophysiological characterization of individual cells and reconstituted membrane systems on microstructured carriers
WO1999039829A1 (en) * 1998-02-04 1999-08-12 Merck & Co., Inc. Virtual wells for use in high throughput screening assays

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5234566A (en) * 1988-08-18 1993-08-10 Australian Membrane And Biotechnology Research Institute Ltd. Sensitivity and selectivity of ion channel biosensor membranes
DE19628928A1 (en) * 1996-07-18 1998-01-22 Basf Ag Solid supports for analytical measurement processes, a process for their production and their use
WO1998047003A1 (en) * 1997-04-17 1998-10-22 Cytonix Corporation An analytical assembly for polymerase chain reaction
WO1998058248A1 (en) * 1997-06-14 1998-12-23 Coventry University Biosensor comprising a lipid membrane containing gated ion channels
WO1999031503A1 (en) * 1997-12-17 1999-06-24 Horst Vogel Positioning and electrophysiological characterization of individual cells and reconstituted membrane systems on microstructured carriers
WO1999039829A1 (en) * 1998-02-04 1999-08-12 Merck & Co., Inc. Virtual wells for use in high throughput screening assays

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9146221B2 (en) 2001-03-24 2015-09-29 Aviva Biosciences Corporation High-density ion transport measurement biochip devices and methods

Also Published As

Publication number Publication date
AU1047401A (en) 2001-06-06
WO2001034764A2 (en) 2001-05-17

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