WO2001041782A3 - Method for administering a cytokine to the central nervous system and the lymphatic system - Google Patents

Method for administering a cytokine to the central nervous system and the lymphatic system Download PDF

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Publication number
WO2001041782A3
WO2001041782A3 PCT/US2000/033220 US0033220W WO0141782A3 WO 2001041782 A3 WO2001041782 A3 WO 2001041782A3 US 0033220 W US0033220 W US 0033220W WO 0141782 A3 WO0141782 A3 WO 0141782A3
Authority
WO
WIPO (PCT)
Prior art keywords
central nervous
nervous system
cytokine
administering
disorders
Prior art date
Application number
PCT/US2000/033220
Other languages
French (fr)
Other versions
WO2001041782A2 (en
Inventor
William H Ii Frey
Original Assignee
Chiron Corp
William H Ii Frey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp, William H Ii Frey filed Critical Chiron Corp
Priority to CA002393688A priority Critical patent/CA2393688A1/en
Priority to AU20698/01A priority patent/AU783208B2/en
Priority to DE60021760T priority patent/DE60021760T2/en
Priority to AT00984018T priority patent/ATE300952T1/en
Priority to JP2001543126A priority patent/JP2003516360A/en
Priority to EP00984018A priority patent/EP1237567B1/en
Priority to IL15010900A priority patent/IL150109A0/en
Publication of WO2001041782A2 publication Critical patent/WO2001041782A2/en
Publication of WO2001041782A3 publication Critical patent/WO2001041782A3/en
Priority to NO20022731A priority patent/NO20022731L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/217—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Abstract

The present invention is directed to a method for delivering cytokines to the central nervous system and the lymphatic system by way of a tissue innervated by the trigeminal nerve and/or olfactory nerve. Cytokines include tumor necrosis factors, interleukins, interferons, particularly interferon-β and its muteins such as IFN-βser17. Such a method of delivery can be useful in the treatment of central nervous system disorders, brain disorders, proliferative, viral, and/or autoimmune disorders such as Sjogren's disorder.
PCT/US2000/033220 1999-12-09 2000-12-08 Method for administering a cytokine to the central nervous system and the lymphatic system WO2001041782A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CA002393688A CA2393688A1 (en) 1999-12-09 2000-12-08 Method for administering a cytokine to the central nervous system and the lymphatic system
AU20698/01A AU783208B2 (en) 1999-12-09 2000-12-08 Method for administering a cytokine to the central nervous system and the lymphatic system
DE60021760T DE60021760T2 (en) 1999-12-09 2000-12-08 METHOD FOR THE ADMINISTRATION OF ACTIVE SUBSTANCES IN THE CENTRAL NERVOUS SYSTEM OR LYMPHIC SYSTEM
AT00984018T ATE300952T1 (en) 1999-12-09 2000-12-08 METHOD FOR ADMINISTRATION OF ACTIVE INGREDIENTS INTO THE CENTRAL NERVOUS SYSTEM OR LYMPH SYSTEM
JP2001543126A JP2003516360A (en) 1999-12-09 2000-12-08 Method of administering cytokine to central nervous system and lymphatic system
EP00984018A EP1237567B1 (en) 1999-12-09 2000-12-08 Method for administering a cytokine to the central nervous system and the lymphatic system
IL15010900A IL150109A0 (en) 1999-12-09 2000-12-08 Method for administering a cytokine to the central nervous system and the lymphatic system
NO20022731A NO20022731L (en) 1999-12-09 2002-06-07 Method of administering a cytokine to the central nervous system and the lymphatic system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20070899P 1999-12-09 1999-12-09
US60/200,708 1999-12-09

Publications (2)

Publication Number Publication Date
WO2001041782A2 WO2001041782A2 (en) 2001-06-14
WO2001041782A3 true WO2001041782A3 (en) 2002-01-17

Family

ID=22742853

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/033220 WO2001041782A2 (en) 1999-12-09 2000-12-08 Method for administering a cytokine to the central nervous system and the lymphatic system

Country Status (10)

Country Link
US (3) US20010043915A1 (en)
EP (1) EP1237567B1 (en)
JP (1) JP2003516360A (en)
AT (1) ATE300952T1 (en)
AU (1) AU783208B2 (en)
CA (1) CA2393688A1 (en)
DE (1) DE60021760T2 (en)
IL (1) IL150109A0 (en)
NO (1) NO20022731L (en)
WO (1) WO2001041782A2 (en)

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Also Published As

Publication number Publication date
AU783208B2 (en) 2005-10-06
DE60021760T2 (en) 2006-06-08
IL150109A0 (en) 2002-12-01
DE60021760D1 (en) 2005-09-08
JP2003516360A (en) 2003-05-13
US20020141971A1 (en) 2002-10-03
US20060159626A1 (en) 2006-07-20
ATE300952T1 (en) 2005-08-15
WO2001041782A2 (en) 2001-06-14
NO20022731D0 (en) 2002-06-07
EP1237567A2 (en) 2002-09-11
CA2393688A1 (en) 2001-06-14
US6991785B2 (en) 2006-01-31
EP1237567B1 (en) 2005-08-03
AU2069801A (en) 2001-06-18
NO20022731L (en) 2002-08-08
US20010043915A1 (en) 2001-11-22

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