WO2001044515A3 - Apparatus for performing biological reactions - Google Patents

Apparatus for performing biological reactions Download PDF

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Publication number
WO2001044515A3
WO2001044515A3 PCT/US2000/034145 US0034145W WO0144515A3 WO 2001044515 A3 WO2001044515 A3 WO 2001044515A3 US 0034145 W US0034145 W US 0034145W WO 0144515 A3 WO0144515 A3 WO 0144515A3
Authority
WO
WIPO (PCT)
Prior art keywords
biological reactions
performing biological
relates
reactions
multiplicity
Prior art date
Application number
PCT/US2000/034145
Other languages
French (fr)
Other versions
WO2001044515A2 (en
WO2001044515A9 (en
Inventor
George W Hawkins
Original Assignee
Motorola Inc
George W Hawkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/464,490 external-priority patent/US6589778B1/en
Application filed by Motorola Inc, George W Hawkins filed Critical Motorola Inc
Priority to CA002394275A priority Critical patent/CA2394275A1/en
Priority to JP2001545592A priority patent/JP2003517156A/en
Priority to EP00991410A priority patent/EP1242819A2/en
Priority to AU32641/01A priority patent/AU778696B2/en
Publication of WO2001044515A2 publication Critical patent/WO2001044515A2/en
Publication of WO2001044515A3 publication Critical patent/WO2001044515A3/en
Publication of WO2001044515A9 publication Critical patent/WO2001044515A9/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1816—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using induction heating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof

Abstract

The present invention relates to an apparatus for performing biological reactions. Specifically, the invention relates to an apparatus for performing nucleic acid hybridization reactions on a substrate layer having a multiplicity of oligonucleotide binding sites disposed thereon, using substrates with flexible covers.
PCT/US2000/034145 1999-12-15 2000-12-15 Apparatus for performing biological reactions WO2001044515A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002394275A CA2394275A1 (en) 1999-12-15 2000-12-15 Apparatus for performing biological reactions
JP2001545592A JP2003517156A (en) 1999-12-15 2000-12-15 Compositions and methods for performing biological reactions
EP00991410A EP1242819A2 (en) 1999-12-15 2000-12-15 Apparatus for performing biological reactions
AU32641/01A AU778696B2 (en) 1999-12-15 2000-12-15 Compositions and methods for performing biological reactions

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/464,490 1999-12-15
US09/464,490 US6589778B1 (en) 1999-12-15 1999-12-15 Method and apparatus for performing biological reactions on a substrate surface
US60576600A 2000-06-28 2000-06-28
US09/605,766 2000-06-28

Publications (3)

Publication Number Publication Date
WO2001044515A2 WO2001044515A2 (en) 2001-06-21
WO2001044515A3 true WO2001044515A3 (en) 2002-03-07
WO2001044515A9 WO2001044515A9 (en) 2002-07-04

Family

ID=27040998

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/034145 WO2001044515A2 (en) 1999-12-15 2000-12-15 Apparatus for performing biological reactions

Country Status (5)

Country Link
EP (1) EP1242819A2 (en)
JP (1) JP2003517156A (en)
AU (1) AU778696B2 (en)
CA (1) CA2394275A1 (en)
WO (1) WO2001044515A2 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0004296D0 (en) * 2000-11-23 2000-11-23 Gyros Ab Device and method for the controlled heating in micro channel systems
WO2002103331A1 (en) * 2001-06-15 2002-12-27 Zeptosens Ag Body for flow-through cells and the use thereof
US20030064507A1 (en) * 2001-07-26 2003-04-03 Sean Gallagher System and methods for mixing within a microfluidic device
CZ297082B6 (en) * 2002-06-03 2006-09-13 Ing. Ilja Krejcí-Engineering Three-dimensional components prepared by thick film technology and method of producing thereof
US20030235521A1 (en) * 2002-06-21 2003-12-25 Shea Laurence R. Array assay devices and methods of using the same
JP4057967B2 (en) * 2002-07-31 2008-03-05 株式会社東芝 Automatic nucleotide sequence analyzer
US7745203B2 (en) 2002-07-31 2010-06-29 Kabushiki Kaisha Toshiba Base sequence detection apparatus and base sequence automatic analyzing apparatus
US6913931B2 (en) 2002-10-03 2005-07-05 3M Innovative Properties Company Devices, methods and systems for low volume microarray processing
US20040101439A1 (en) * 2002-11-21 2004-05-27 Fusco Adam J Biological and chemical reaction devices and methods of manufacture
WO2005016532A2 (en) * 2003-06-13 2005-02-24 Corning Incorporated Automated reaction chamber system for biological assays
DE10340473B4 (en) * 2003-09-03 2007-08-23 Eppendorf Ag Cover of a hybridization chamber
KR100601936B1 (en) * 2003-12-17 2006-07-14 삼성전자주식회사 A patch for microarray reaction chamber having adhesive means support and two or more adhesion materials
DE102004022263A1 (en) * 2004-05-06 2005-12-15 Clondiag Chip Technologies Gmbh Apparatus and method for detecting molecular interactions
JP4732135B2 (en) * 2005-11-10 2011-07-27 キヤノン株式会社 Reactor
JP4705504B2 (en) * 2006-04-05 2011-06-22 アイダエンジニアリング株式会社 Microfluidic chip
CL2008003007A1 (en) * 2007-10-12 2009-10-02 Bigtec Private Ltd A microchip with layers of low temperature firing ceramics (ltcc) forming a reaction chamber, conductive rings that surround the reaction chamber and a heater that supplies heat to the rings, the microchip manufacturing method and a micro polymerase chain reaction (pcr) device.
US20100071614A1 (en) * 2008-09-22 2010-03-25 Momentive Performance Materials, Inc. Fluid distribution apparatus and method of forming the same
JP2010236969A (en) * 2009-03-31 2010-10-21 Hitachi High-Technologies Corp Nucleic acid analysis device, nucleic acid analyzer, and nucleic acid analysis method
JP6094393B2 (en) * 2013-06-13 2017-03-15 住友ベークライト株式会社 Covering body and method of using the covering body

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WO1997010056A2 (en) * 1995-09-12 1997-03-20 Becton Dickinson And Company Device and method for dna amplification and assay
WO1999019717A1 (en) * 1997-10-15 1999-04-22 Aclara Biosciences, Inc. Laminate microstructure device and method for making same
WO1999042558A1 (en) * 1998-02-20 1999-08-26 Nanogen, Inc. Advanced active devices and methods for molecular biological analysis and diagnostics
US5945334A (en) * 1994-06-08 1999-08-31 Affymetrix, Inc. Apparatus for packaging a chip

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US5229297A (en) * 1989-02-03 1993-07-20 Eastman Kodak Company Containment cuvette for PCR and method of use
US5856174A (en) * 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5907703A (en) * 1996-05-08 1999-05-25 Mijenix Corporation Device driver for accessing computer files

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
US5945334A (en) * 1994-06-08 1999-08-31 Affymetrix, Inc. Apparatus for packaging a chip
WO1997010056A2 (en) * 1995-09-12 1997-03-20 Becton Dickinson And Company Device and method for dna amplification and assay
WO1999019717A1 (en) * 1997-10-15 1999-04-22 Aclara Biosciences, Inc. Laminate microstructure device and method for making same
WO1999042558A1 (en) * 1998-02-20 1999-08-26 Nanogen, Inc. Advanced active devices and methods for molecular biological analysis and diagnostics

Non-Patent Citations (1)

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Title
See also references of EP1242819A2 *

Also Published As

Publication number Publication date
WO2001044515A2 (en) 2001-06-21
EP1242819A2 (en) 2002-09-25
JP2003517156A (en) 2003-05-20
WO2001044515A9 (en) 2002-07-04
CA2394275A1 (en) 2001-06-21
AU3264101A (en) 2001-06-25
AU778696B2 (en) 2004-12-16

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