WO2001051083A3 - Innate immunity-stimulating compositions of cpg and saponin and methods thereof - Google Patents
Innate immunity-stimulating compositions of cpg and saponin and methods thereof Download PDFInfo
- Publication number
- WO2001051083A3 WO2001051083A3 PCT/US2001/001046 US0101046W WO0151083A3 WO 2001051083 A3 WO2001051083 A3 WO 2001051083A3 US 0101046 W US0101046 W US 0101046W WO 0151083 A3 WO0151083 A3 WO 0151083A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- saponin
- innate immunity
- cpg
- methods
- stimulating compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001551506A JP2003527352A (en) | 2000-01-13 | 2001-01-12 | Innate immune stimulating compounds of CPG and saponin and methods thereof |
AU27877/01A AU781812B2 (en) | 2000-01-13 | 2001-01-12 | Innate immunity-stimulating compositions of CPG and saponin and methods thereof |
CA002397374A CA2397374A1 (en) | 2000-01-13 | 2001-01-12 | Innate immunity-stimulating compositions of cpg and saponin and methods thereof |
EP01902032A EP1250150A2 (en) | 2000-01-13 | 2001-01-12 | Innate immunity-stimulating compositions of cpg and saponin and methods thereof |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17584000P | 2000-01-13 | 2000-01-13 | |
US60/175,840 | 2000-01-13 | ||
US20085300P | 2000-05-01 | 2000-05-01 | |
US60/200,853 | 2000-05-01 | ||
US36994100A | 2000-08-06 | 2000-08-06 | |
US09/369,941 | 2000-08-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001051083A2 WO2001051083A2 (en) | 2001-07-19 |
WO2001051083A3 true WO2001051083A3 (en) | 2002-01-03 |
Family
ID=27390599
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/001046 WO2001051083A2 (en) | 2000-01-13 | 2001-01-12 | Innate immunity-stimulating compositions of cpg and saponin and methods thereof |
Country Status (4)
Country | Link |
---|---|
JP (1) | JP2003527352A (en) |
AU (1) | AU781812B2 (en) |
CA (1) | CA2397374A1 (en) |
WO (1) | WO2001051083A2 (en) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
EP2204186B1 (en) | 1999-02-17 | 2016-04-06 | CSL Limited | Immunogenic complexes and methods relating thereto |
GB9908885D0 (en) * | 1999-04-19 | 1999-06-16 | Smithkline Beecham Biolog | Vccine |
CZ303515B6 (en) | 1999-04-19 | 2012-11-07 | Smithkline Beecham Biologicals S. A. | Adjuvant compositions |
US20020098199A1 (en) * | 2000-03-10 | 2002-07-25 | Gary Van Nest | Methods of suppressing hepatitis virus infection using immunomodulatory polynucleotide sequences |
CN1441676B (en) | 2000-03-31 | 2012-08-22 | 普渡研究基金会 | Method of treatment using ligand-immunogen conjugates |
BR0114786A (en) * | 2000-10-18 | 2003-08-12 | Glaxosmithkline Biolog Sa | Immunogenic composition, method of treatment of a patient suffering from, or susceptible to, a cancer, and, use of a combination of a saponin, an immunostimulating oligotide and a cancer antigen, and, method for the manufacture of a composition. |
CA2492826C (en) | 2001-09-14 | 2016-12-13 | Cytos Biotechnology Ag | Encapsulation of unmethylated cpg-containing oligonucleotides into virus-like particles: method of preparation and use |
CA2461877A1 (en) * | 2001-09-28 | 2003-04-10 | Purdue Research Foundation | Method of treatment using ligand-immunogen conjugates |
JP5153990B2 (en) | 2001-12-21 | 2013-02-27 | シーエスエル、リミテッド | Compositions containing immunoreactive reagents and saponins, and methods of use thereof |
CA2388049A1 (en) | 2002-05-30 | 2003-11-30 | Immunotech S.A. | Immunostimulatory oligonucleotides and uses thereof |
CN1662253A (en) * | 2002-06-20 | 2005-08-31 | 赛托斯生物技术公司 | Packaged virus-like particles for use as adjuvants: method of preparation and use |
CA2502015A1 (en) | 2002-12-11 | 2004-06-24 | Coley Pharmaceutical Group, Inc. | 5' cpg nucleic acids and methods of use |
JP4976848B2 (en) | 2003-02-20 | 2012-07-18 | ユニバーシティー オブ コネティカット ヘルス センター | Methods and compositions for the treatment of cancer and infectious diseases using alpha (2) macroglobulin-antigen molecule complexes |
EP1670507A4 (en) | 2003-09-12 | 2007-10-17 | Antigenics Inc | Vaccine for treatment and prevention of herpes simplex virus infection |
WO2007092299A2 (en) | 2006-02-03 | 2007-08-16 | Purdue Research Foundation | Targeted conjugates and radiation |
EP2413953B1 (en) | 2009-04-03 | 2017-11-08 | Agenus Inc. | Methods for preparing and using multichaperone-antigen complexes |
JP6045895B2 (en) | 2012-10-01 | 2016-12-14 | 株式会社トプコン | Ophthalmic observation device |
IL293135A (en) | 2015-05-13 | 2022-07-01 | Agenus Inc | Composition comprising at least two different complexes of a purified stress protein bound to an antigenic peptide |
CA2972174C (en) | 2016-07-29 | 2022-01-11 | Saponin Research Center S.A. | Use of quillaja saponaria extracts for the prevention and control of viral infections in fish |
US20180325970A1 (en) | 2016-07-29 | 2018-11-15 | Saponin Research Center S.A. | Use of quillaja saponaria extracts for the prevention and control of bacterial infections in fish |
US11185735B2 (en) | 2019-03-11 | 2021-11-30 | Rom Technologies, Inc. | System, method and apparatus for adjustable pedal crank |
US11471729B2 (en) | 2019-03-11 | 2022-10-18 | Rom Technologies, Inc. | System, method and apparatus for a rehabilitation machine with a simulated flywheel |
US20200289045A1 (en) | 2019-03-11 | 2020-09-17 | Rom Technologies, Inc. | Single sensor wearable device for monitoring joint extension and flexion |
US11801423B2 (en) | 2019-05-10 | 2023-10-31 | Rehab2Fit Technologies, Inc. | Method and system for using artificial intelligence to interact with a user of an exercise device during an exercise session |
US11904207B2 (en) | 2019-05-10 | 2024-02-20 | Rehab2Fit Technologies, Inc. | Method and system for using artificial intelligence to present a user interface representing a user's progress in various domains |
US11701548B2 (en) | 2019-10-07 | 2023-07-18 | Rom Technologies, Inc. | Computer-implemented questionnaire for orthopedic treatment |
US11515021B2 (en) | 2019-10-03 | 2022-11-29 | Rom Technologies, Inc. | Method and system to analytically optimize telehealth practice-based billing processes and revenue while enabling regulatory compliance |
US11830601B2 (en) | 2019-10-03 | 2023-11-28 | Rom Technologies, Inc. | System and method for facilitating cardiac rehabilitation among eligible users |
US11923065B2 (en) | 2019-10-03 | 2024-03-05 | Rom Technologies, Inc. | Systems and methods for using artificial intelligence and machine learning to detect abnormal heart rhythms of a user performing a treatment plan with an electromechanical machine |
US11101028B2 (en) | 2019-10-03 | 2021-08-24 | Rom Technologies, Inc. | Method and system using artificial intelligence to monitor user characteristics during a telemedicine session |
US11915815B2 (en) | 2019-10-03 | 2024-02-27 | Rom Technologies, Inc. | System and method for using artificial intelligence and machine learning and generic risk factors to improve cardiovascular health such that the need for additional cardiac interventions is mitigated |
US11887717B2 (en) | 2019-10-03 | 2024-01-30 | Rom Technologies, Inc. | System and method for using AI, machine learning and telemedicine to perform pulmonary rehabilitation via an electromechanical machine |
US11075000B2 (en) | 2019-10-03 | 2021-07-27 | Rom Technologies, Inc. | Method and system for using virtual avatars associated with medical professionals during exercise sessions |
US11915816B2 (en) | 2019-10-03 | 2024-02-27 | Rom Technologies, Inc. | Systems and methods of using artificial intelligence and machine learning in a telemedical environment to predict user disease states |
US20210134463A1 (en) | 2019-10-03 | 2021-05-06 | Rom Technologies, Inc. | Systems and methods for remotely-enabled identification of a user infection |
US11756666B2 (en) | 2019-10-03 | 2023-09-12 | Rom Technologies, Inc. | Systems and methods to enable communication detection between devices and performance of a preventative action |
US11826613B2 (en) | 2019-10-21 | 2023-11-28 | Rom Technologies, Inc. | Persuasive motivation for orthopedic treatment |
KR20220114031A (en) | 2019-12-13 | 2022-08-17 | 그랜드 테라박 라이프 사이언스 (난징) 씨오., 엘티디. | Immune stimulating composition and use thereof |
CN115410704A (en) * | 2020-07-06 | 2022-11-29 | 罗姆科技股份有限公司 | Method and system for rehabilitating a subject via telemedicine |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998037919A1 (en) * | 1997-02-28 | 1998-09-03 | University Of Iowa Research Foundation | USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS |
WO1999061056A2 (en) * | 1998-05-22 | 1999-12-02 | Loeb Health Research Institute At The Ottawa Hospital | Methods and products for inducing mucosal immunity |
WO2000009159A1 (en) * | 1998-08-10 | 2000-02-24 | Aquila Biopharmaceuticals, Inc. | Compositions of cpg and saponin adjuvants and methods thereof |
WO2000062800A2 (en) * | 1999-04-19 | 2000-10-26 | Smithkline Beecham Biologicals Sa | Adjuvant composition comprising saponin and an immunostimulatory oligonucleotide |
-
2001
- 2001-01-12 AU AU27877/01A patent/AU781812B2/en not_active Ceased
- 2001-01-12 JP JP2001551506A patent/JP2003527352A/en active Pending
- 2001-01-12 CA CA002397374A patent/CA2397374A1/en not_active Abandoned
- 2001-01-12 WO PCT/US2001/001046 patent/WO2001051083A2/en not_active Application Discontinuation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998037919A1 (en) * | 1997-02-28 | 1998-09-03 | University Of Iowa Research Foundation | USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS |
WO1999061056A2 (en) * | 1998-05-22 | 1999-12-02 | Loeb Health Research Institute At The Ottawa Hospital | Methods and products for inducing mucosal immunity |
WO2000009159A1 (en) * | 1998-08-10 | 2000-02-24 | Aquila Biopharmaceuticals, Inc. | Compositions of cpg and saponin adjuvants and methods thereof |
WO2000062800A2 (en) * | 1999-04-19 | 2000-10-26 | Smithkline Beecham Biologicals Sa | Adjuvant composition comprising saponin and an immunostimulatory oligonucleotide |
Non-Patent Citations (1)
Title |
---|
KIM SOO KIE ET AL: "Effect of immunological adjuvant combinations on the antibody and T-cell response to vaccination with MUC1-KLH and GD3-KLH conjugates.", VACCINE, vol. 19, no. 4-5, 15 October 2000 (2000-10-15), pages 530 - 537, XP000999847, ISSN: 0264-410X * |
Also Published As
Publication number | Publication date |
---|---|
AU781812B2 (en) | 2005-06-16 |
JP2003527352A (en) | 2003-09-16 |
AU2787701A (en) | 2001-07-24 |
WO2001051083A2 (en) | 2001-07-19 |
CA2397374A1 (en) | 2001-07-19 |
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