WO2001051663A3 - Integrated systems and methods for diversity generation and screening - Google Patents
Integrated systems and methods for diversity generation and screening Download PDFInfo
- Publication number
- WO2001051663A3 WO2001051663A3 PCT/US2001/001056 US0101056W WO0151663A3 WO 2001051663 A3 WO2001051663 A3 WO 2001051663A3 US 0101056 W US0101056 W US 0101056W WO 0151663 A3 WO0151663 A3 WO 0151663A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- screening
- methods
- integrated systems
- diversity generation
- systems
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
- C12N15/1031—Mutagenizing nucleic acids mutagenesis by gene assembly, e.g. assembly by oligonucleotide extension PCR
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
- C12N15/1027—Mutagenizing nucleic acids by DNA shuffling, e.g. RSR, STEP, RPR
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/04—Integrated apparatus specially adapted for both screening libraries and identifying library members
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/50—Mutagenesis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00378—Piezo-electric or ink jet dispensers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00585—Parallel processes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00675—In-situ synthesis on the substrate
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00686—Automatic
- B01J2219/00689—Automatic using computers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00695—Synthesis control routines, e.g. using computer programs
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/007—Simulation or vitual synthesis
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU27881/01A AU2788101A (en) | 2000-01-11 | 2001-01-10 | Integrated systems and methods for diversity generation and screening |
IL15029101A IL150291A0 (en) | 2000-01-11 | 2001-01-10 | Integrated systems and methods for diversity generation and screening |
EP01902036A EP1276900A2 (en) | 2000-01-11 | 2001-01-10 | Integrated systems and methods for diversity generation and screening |
JP2001551237A JP2003519495A (en) | 2000-01-11 | 2001-01-10 | Integrated systems and methods for diversity generation and screening |
CA002396320A CA2396320A1 (en) | 2000-01-11 | 2001-01-10 | Integrated systems and methods for diversity generation and screening |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17555100P | 2000-01-11 | 2000-01-11 | |
US60/175,551 | 2000-01-11 | ||
US21394700P | 2000-06-23 | 2000-06-23 | |
US60/213,947 | 2000-06-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001051663A2 WO2001051663A2 (en) | 2001-07-19 |
WO2001051663A3 true WO2001051663A3 (en) | 2002-06-13 |
Family
ID=26871316
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/001056 WO2001051663A2 (en) | 2000-01-11 | 2001-01-10 | Integrated systems and methods for diversity generation and screening |
Country Status (8)
Country | Link |
---|---|
US (5) | US20010039014A1 (en) |
EP (1) | EP1276900A2 (en) |
JP (1) | JP2003519495A (en) |
AU (1) | AU2788101A (en) |
CA (1) | CA2396320A1 (en) |
IL (1) | IL150291A0 (en) |
SG (1) | SG121902A1 (en) |
WO (1) | WO2001051663A2 (en) |
Families Citing this family (191)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6764835B2 (en) * | 1995-12-07 | 2004-07-20 | Diversa Corporation | Saturation mutageneis in directed evolution |
US6537776B1 (en) * | 1999-06-14 | 2003-03-25 | Diversa Corporation | Synthetic ligation reassembly in directed evolution |
US20030092023A1 (en) * | 1998-08-12 | 2003-05-15 | Daniel Dupret | Method of shuffling polynucleotides using templates |
US6991922B2 (en) | 1998-08-12 | 2006-01-31 | Proteus S.A. | Process for in vitro creation of recombinant polynucleotide sequences by oriented ligation |
US6951719B1 (en) * | 1999-08-11 | 2005-10-04 | Proteus S.A. | Process for obtaining recombined nucleotide sequences in vitro, libraries of sequences and sequences thus obtained |
US20090130718A1 (en) * | 1999-02-04 | 2009-05-21 | Diversa Corporation | Gene site saturation mutagenesis |
US7555492B2 (en) * | 1999-11-05 | 2009-06-30 | The Board Of Trustees At The Leland Stanford Junior University | System and method for internet-accessible tools and knowledge base for protocol design, metadata capture and laboratory experiment management |
AU2788101A (en) * | 2000-01-11 | 2001-07-24 | Maxygen, Inc. | Integrated systems and methods for diversity generation and screening |
WO2001064864A2 (en) * | 2000-02-28 | 2001-09-07 | Maxygen, Inc. | Single-stranded nucleic acid template-mediated recombination and nucleic acid fragment isolation |
CA2419490C (en) | 2000-08-15 | 2010-01-26 | Discerna Limited | Functional protein arrays |
AU2002230526A1 (en) * | 2000-12-01 | 2002-06-11 | Cornell Research Foundation, Inc. | Detection of nucleic acid differences using combined endonuclease cleavage and ligation reactions |
US6958213B2 (en) * | 2000-12-12 | 2005-10-25 | Alligator Bioscience Ab | Method for in vitro molecular evolution of protein function |
US20020086292A1 (en) | 2000-12-22 | 2002-07-04 | Shigeaki Harayama | Synthesis of hybrid polynucleotide molecules using single-stranded polynucleotide molecules |
EP1360490B1 (en) | 2001-01-23 | 2011-12-21 | President and Fellows of Harvard College | Nucleic-acid programmable protein arrays |
US6748337B2 (en) * | 2001-03-14 | 2004-06-08 | Wardlaw Partners, Lp | Method and apparatus for providing quality control in an instrument for medical analysis |
US7807408B2 (en) * | 2001-03-19 | 2010-10-05 | President & Fellows Of Harvard College | Directed evolution of proteins |
WO2002074978A2 (en) * | 2001-03-19 | 2002-09-26 | President And Fellows Of Harvard College | Nucleic acid shuffling |
EP1383887A4 (en) * | 2001-05-03 | 2004-07-07 | Rensselaer Polytech Inst | Novel methods of directed evolution |
EP1262545A1 (en) * | 2001-05-31 | 2002-12-04 | Direvo Biotech AG | Microstructures and the use thereof in the targeted evolution of biomolecules |
US20030082551A1 (en) * | 2001-09-28 | 2003-05-01 | Zarling David A. | High-throughput gene cloning and phenotypic screening |
GB0126887D0 (en) * | 2001-11-08 | 2002-01-02 | Univ London | Method for producing and identifying soluble protein domains |
GB0127913D0 (en) * | 2001-11-21 | 2002-01-16 | Elan Vital Uk Ltd | Fluid analyser systems |
AU2002353018A1 (en) * | 2001-12-03 | 2003-06-17 | Dyax Corporation | Library screening |
US20030124539A1 (en) * | 2001-12-21 | 2003-07-03 | Affymetrix, Inc. A Corporation Organized Under The Laws Of The State Of Delaware | High throughput resequencing and variation detection using high density microarrays |
US20040009498A1 (en) * | 2002-01-14 | 2004-01-15 | Diversa Corporation | Chimeric antigen binding molecules and methods for making and using them |
US20040063109A2 (en) * | 2002-01-25 | 2004-04-01 | Applera Corporation | Single-tube, ready-to-use assay kits, and methods using same |
US20090239233A1 (en) * | 2002-01-25 | 2009-09-24 | Applera Corporation | Single-tube, ready-to-use assay kits, and methods using same |
AU2003243691A1 (en) * | 2002-06-20 | 2004-01-06 | Primera Biosystems, Inc. | Apparatus for polynucleotide detection and quantitation |
AU2003276870A1 (en) * | 2002-09-07 | 2004-03-29 | Lightwave Bioapplications | Bioanalysis systems including optical integrated circuit |
US6804579B1 (en) * | 2002-10-16 | 2004-10-12 | Abb, Inc. | Robotic wash cell using recycled pure water |
US7112552B2 (en) * | 2002-10-18 | 2006-09-26 | Promega Corporation | Compositions for separating molecules |
US20040081969A1 (en) * | 2002-10-29 | 2004-04-29 | Ilsley Diane D. | Devices and methods for evaulating the quality of a sample for use in an array assay |
US20050089875A1 (en) * | 2002-11-21 | 2005-04-28 | Sention Inc. | Quantitative analysis of expression profiling information produced at various stages of an amplification process |
DE10393861B4 (en) * | 2002-12-09 | 2016-12-15 | Waters Technologies Corp. (N.D.Ges.D. Staates Delaware) | Device for a freeze-thaw valve circuit and method for switching a freeze-thaw valve |
US7879580B2 (en) * | 2002-12-10 | 2011-02-01 | Massachusetts Institute Of Technology | Methods for high fidelity production of long nucleic acid molecules |
US20060094108A1 (en) * | 2002-12-20 | 2006-05-04 | Karl Yoder | Thermal cycler for microfluidic array assays |
EP1608952B1 (en) * | 2002-12-20 | 2016-08-10 | Life Technologies Corporation | Assay apparatus and method using microfluidic arrays |
WO2004083806A2 (en) * | 2003-01-22 | 2004-09-30 | University Of South Florida | Autonomous genosensor apparatus and methods for use |
US7041481B2 (en) | 2003-03-14 | 2006-05-09 | The Regents Of The University Of California | Chemical amplification based on fluid partitioning |
JP3944576B2 (en) * | 2003-03-28 | 2007-07-11 | 独立行政法人産業技術総合研究所 | Aptamer acquisition method using microarray |
CN1537954A (en) * | 2003-04-18 | 2004-10-20 | ������������ʽ���� | Expressing genetic analysis method and probe reagent box for expressing genetic analysng |
WO2004097585A2 (en) * | 2003-04-24 | 2004-11-11 | Stanford University | System and method for internet-accessible tools and knowledge base for protocol design, metadata capture and laboratory experiment management |
WO2004096999A2 (en) * | 2003-04-28 | 2004-11-11 | Exelixis, Inc. | In vitro translation system |
US20040225550A1 (en) * | 2003-05-06 | 2004-11-11 | Interactive Clinical Systems, Inc. | Software program for, system for, and method of facilitating staffing of an opening in a work schedule at a facility |
US7353116B2 (en) * | 2003-07-31 | 2008-04-01 | Agilent Technologies, Inc. | Chemical array with test dependent signal reading or processing |
US20050026154A1 (en) * | 2003-07-31 | 2005-02-03 | Laurakay Bruhn | Masking chemical arrays |
EP1660885B1 (en) * | 2003-08-07 | 2012-10-03 | CellFree Sciences Co., Ltd. | Reagent for producing a protein chip |
US20060188947A1 (en) * | 2003-08-07 | 2006-08-24 | Yaeta Endo | Reagent for producing a protein chip |
US20050032072A1 (en) * | 2003-08-08 | 2005-02-10 | Perlegen Sciences, Inc. | Fragmentation and labelling with a programmable temperature control module |
GB0324456D0 (en) * | 2003-10-20 | 2003-11-19 | Isis Innovation | Parallel DNA sequencing methods |
JP4572304B2 (en) * | 2004-01-27 | 2010-11-04 | 独立行政法人情報通信研究機構 | Chemical genetic programming device and chemical genetic programming method |
WO2006028508A2 (en) * | 2004-03-23 | 2006-03-16 | President And Fellows Of Harvard College | Methods and apparatus for characterizing polynucleotides |
EP1738667B8 (en) * | 2004-04-23 | 2012-08-22 | Panasonic Electric Works Co., Ltd. | Fan heater with electrostatic atomizer |
US20050261950A1 (en) * | 2004-05-21 | 2005-11-24 | Mccandliss Glenn A | Method of scheduling appointment coverage for service professionals |
US20050280826A1 (en) * | 2004-06-01 | 2005-12-22 | Affymetrix, Inc. | Methods for examination of microarrays using surface reflectance measuring tool |
WO2006000999A1 (en) * | 2004-06-24 | 2006-01-05 | University College Cork - National University Of Ireland, Cork | Support for biological or chemical arrays having increased spot quality |
US20060019258A1 (en) * | 2004-07-20 | 2006-01-26 | Illumina, Inc. | Methods and compositions for detection of small interfering RNA and micro-RNA |
US8617895B2 (en) * | 2004-09-23 | 2013-12-31 | Tripath Imaging, Inc. | Polycationic quaternary ammonium polymer coatings for immobilizing biological samples |
US20060106774A1 (en) * | 2004-11-16 | 2006-05-18 | Cohen Peter D | Using qualifications of users to facilitate user performance of tasks |
US8005697B1 (en) | 2004-11-16 | 2011-08-23 | Amazon Technologies, Inc. | Performing automated price determination for tasks to be performed |
US7945469B2 (en) * | 2004-11-16 | 2011-05-17 | Amazon Technologies, Inc. | Providing an electronic marketplace to facilitate human performance of programmatically submitted tasks |
US8126085B2 (en) * | 2004-11-22 | 2012-02-28 | Intel Corporation | Method and apparatus to estimate channel tap |
WO2006086292A2 (en) * | 2005-02-07 | 2006-08-17 | Advion Biosciences, Inc. | Ultra-low volume fraction collection and analysis |
US20060257858A1 (en) * | 2005-04-01 | 2006-11-16 | Invitrogen Corporation | Methods and compositions for introducing biopolymers into cells |
US20060246576A1 (en) * | 2005-04-06 | 2006-11-02 | Affymetrix, Inc. | Fluidic system and method for processing biological microarrays in personal instrumentation |
US7883669B2 (en) * | 2005-04-20 | 2011-02-08 | Fluidigm Corporation | Analysis engine and database for manipulating parameters for fluidic systems on a chip |
DE102005018337A1 (en) * | 2005-04-20 | 2006-11-02 | Micronas Gmbh | Micro-optical detection system and method for determining temperature-dependent parameters of analytes |
DE102005028897A1 (en) * | 2005-06-17 | 2006-12-28 | Eckert & Ziegler Eurotope Gmbh | Arrangement and method for processing chemical substances, computer program for controlling such an arrangement and a corresponding computer-readable storage medium |
ATE510930T1 (en) | 2005-08-02 | 2011-06-15 | Rubicon Genomics Inc | COMPOSITIONS AND METHODS FOR EDITING AND AMPLIFICATION OF DNA USING MULTIPLE ENZYMES IN A SINGLE REACTION |
DE102005037351B3 (en) * | 2005-08-08 | 2007-01-11 | Geneart Ag | In vitro method for directed evolution of proteins, useful e.g. in pharmaceutical development, uses expression system for performing translation, transcription and reverse transcription |
US20070184462A1 (en) * | 2005-09-21 | 2007-08-09 | Zachary Burton | Apparatus and method for solid-phase kinetic analysis of templated elongation reactions |
US20070116241A1 (en) * | 2005-11-10 | 2007-05-24 | Flocken Phil A | Support case management system |
US20070172395A1 (en) * | 2006-01-20 | 2007-07-26 | Applera Corporation | Thermally Conductive Microplate |
WO2007095007A2 (en) * | 2006-02-14 | 2007-08-23 | Albert Einstein College Of Medicine Of Yeshiva University | Systematic genomic library and uses thereof |
US20070207483A1 (en) * | 2006-03-02 | 2007-09-06 | Bio-Rad Laboratories, Inc. | BUFFERS FOR DETECTION OF mRNA SEPARATED IN A MICROFLUIDIC DEVICE |
US8178316B2 (en) | 2006-06-29 | 2012-05-15 | President And Fellows Of Harvard College | Evaluating proteins |
WO2008127382A2 (en) * | 2006-10-19 | 2008-10-23 | Yale University | Computational design of ribozymes |
JP5187932B2 (en) * | 2006-11-01 | 2013-04-24 | 独立行政法人科学技術振興機構 | Biomolecule assay chip |
US20080124777A1 (en) * | 2006-11-29 | 2008-05-29 | Canon U.S. Life Sciences, Inc. | Method for releasing genetic material from solid phase |
US8338166B2 (en) * | 2007-01-04 | 2012-12-25 | Lawrence Livermore National Security, Llc | Sorting, amplification, detection, and identification of nucleic acid subsequences in a complex mixture |
US7991635B2 (en) * | 2007-01-17 | 2011-08-02 | Larry Hartmann | Management of job candidate interview process using online facility |
EP2118281A2 (en) | 2007-02-12 | 2009-11-18 | Codexis, Inc. | Structure-activity relationships |
EP2160478B1 (en) * | 2007-06-06 | 2014-08-27 | Siemens Healthcare Diagnostics Inc. | Predictive diagnostics for kidney disease |
US20170022558A1 (en) * | 2007-10-30 | 2017-01-26 | Complete Genomics, Inc. | Integrated system for nucleic acid sequence and analysis |
CA2705605A1 (en) * | 2008-01-15 | 2009-07-23 | Uop Llc | Multiautoclave with set of vessels for combinatorial synthesis of zeolites and other materials |
EP2250286A1 (en) * | 2008-02-15 | 2010-11-17 | Life Technologies Corporation | Methods and compositions for shearing of polymers by sonication |
EP2626703B1 (en) | 2008-03-27 | 2017-05-03 | Promega Corporation | Protein labeling with cyanobenzothiazole conjugates |
US9328172B2 (en) * | 2008-04-05 | 2016-05-03 | Single Cell Technology, Inc. | Method of obtaining antibodies of interest and nucleotides encoding same |
EP2294217A4 (en) * | 2008-05-23 | 2012-10-31 | Life Technologies Corp | Methods for removing nucleic acid contamination from reagents |
ES2705694T3 (en) * | 2008-06-13 | 2019-03-26 | Codexis Inc | Method of synthesis of polynucleotide variants |
US20090312196A1 (en) * | 2008-06-13 | 2009-12-17 | Codexis, Inc. | Method of synthesizing polynucleotide variants |
US8383346B2 (en) * | 2008-06-13 | 2013-02-26 | Codexis, Inc. | Combined automated parallel synthesis of polynucleotide variants |
US9393566B2 (en) * | 2008-06-23 | 2016-07-19 | Canon U.S. Life Sciences, Inc. | System and method for temperature referencing for melt curve data collection |
EP2299253B1 (en) * | 2008-07-09 | 2019-01-02 | The Furukawa Electric Co., Ltd. | Specimen identification and dispensation device and specimen identification and dispensation method |
WO2010030716A1 (en) * | 2008-09-10 | 2010-03-18 | Igor Kutyavin | Detection of nucleic acids by oligonucleotide probes cleaved in presence of endonuclease v |
JP2010110262A (en) * | 2008-11-06 | 2010-05-20 | Hitachi Maxell Ltd | Method for amplifying nucleic acid by using well plate |
KR101423936B1 (en) * | 2009-03-11 | 2014-07-29 | (주)바이오니아 | Universal automatic apparatus for real time monitoring of products of nucleic acid amplification reaction and method thereof |
CN102428459B (en) * | 2009-05-15 | 2014-10-22 | BioFire诊断公司 | Systems and methods for automated melting curve analysis |
EP2437887B1 (en) | 2009-06-04 | 2016-05-11 | Lockheed Martin Corporation | Multiple-sample microfluidic chip for dna analysis |
ITTO20090860A1 (en) * | 2009-11-10 | 2011-05-11 | Molecular Stamping S R L | METHOD FOR MAKING LONG OLIGONUCLEOTID AND MICROARRAY MICROARRAYS WITH LONG OLIGONUCLEOTIDS |
US9034575B2 (en) * | 2010-03-04 | 2015-05-19 | Roche Molecular Systems, Inc. | Workflow timing between modules |
US20120058900A1 (en) * | 2010-03-04 | 2012-03-08 | Roche Molecular Systems, Inc. | Hardware architecture of analyzers |
US20110312712A1 (en) * | 2010-06-17 | 2011-12-22 | Geneasys Pty Ltd | Genetic analysis loc for pcr amplification of nucleic acids from whole blood |
CN105964312A (en) | 2010-07-22 | 2016-09-28 | 基因细胞生物系统有限公司 | Composite liquid cells |
TWI510791B (en) * | 2010-08-05 | 2015-12-01 | Himax Tech Ltd | Testing device and related testing method |
DK2603325T3 (en) * | 2010-08-11 | 2016-11-07 | Aushon Biosystems | METHOD AND SYSTEM FOR APPLICATION OF BLOCKING MATERIAL ON sample substrates |
AU2011315951B2 (en) | 2010-10-15 | 2015-03-19 | Lockheed Martin Corporation | Micro fluidic optic design |
CN102162792B (en) * | 2011-01-10 | 2012-10-24 | 南京航空航天大学 | HPRT (hypoxanthine phosphoribosyl transferase) body gene mutation detection method based on surface plasmon resonance |
WO2012109574A2 (en) * | 2011-02-11 | 2012-08-16 | Nabsys, Inc. | Assay methods using dna binding proteins |
GB2489714B (en) * | 2011-04-05 | 2013-11-06 | Tracesa Ltd | Fluid Identification Method |
WO2013074643A2 (en) | 2011-11-14 | 2013-05-23 | Aushon Biosystems, Inc. | Systems and methods to enhance consistency of assay performance |
AU2013202808B2 (en) | 2012-07-31 | 2014-11-13 | Gen-Probe Incorporated | System and method for performing multiplex thermal melt analysis |
CA2791003C (en) * | 2012-09-27 | 2013-08-06 | Cinrg Systems Inc. | Liquid sample testing apparatus |
CA2888042A1 (en) | 2012-11-27 | 2014-06-05 | Gencell Biosystems Ltd. | Handling liquid samples |
EP2971137B1 (en) * | 2013-03-15 | 2018-05-09 | The Broad Institute, Inc. | Methods for the detection of dna-rna proximity in vivo |
TWI695067B (en) | 2013-08-05 | 2020-06-01 | 美商扭轉生物科技有限公司 | De novo synthesized gene libraries |
US10438225B1 (en) | 2013-12-18 | 2019-10-08 | Amazon Technologies, Inc. | Game-based automated agent detection |
US9985943B1 (en) | 2013-12-18 | 2018-05-29 | Amazon Technologies, Inc. | Automated agent detection using multiple factors |
EP3105326A4 (en) * | 2014-02-10 | 2018-01-10 | Gencell Biosystems Limited | Composite liquid cell (clc) mediated nucleic acid library preparation device, and methods for using the same |
CA2975855A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Compositions and methods for synthetic gene assembly |
US10669304B2 (en) | 2015-02-04 | 2020-06-02 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
CN107430061B (en) | 2015-02-17 | 2020-11-06 | 埃克斯雷姆Ip英国有限责任公司 | Techniques for temperature control of polarimeter sample chambers |
US9981239B2 (en) | 2015-04-21 | 2018-05-29 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
WO2017049231A1 (en) | 2015-09-18 | 2017-03-23 | Twist Bioscience Corporation | Oligonucleic acid variant libraries and synthesis thereof |
US11512347B2 (en) | 2015-09-22 | 2022-11-29 | Twist Bioscience Corporation | Flexible substrates for nucleic acid synthesis |
CN108603307A (en) | 2015-12-01 | 2018-09-28 | 特韦斯特生物科学公司 | functionalized surface and its preparation |
EP3313977B1 (en) | 2016-01-29 | 2020-08-19 | Hewlett-Packard Development Company, L.P. | Sample-reagent mixture thermal cycling |
EP3452587B1 (en) | 2016-05-05 | 2021-09-08 | Codexis, Inc. | Penicillin-g acylases |
WO2017201344A1 (en) * | 2016-05-18 | 2017-11-23 | Leonardi Anthony | Genetic customization of an organism based upon environmental parameters |
GB2568444A (en) | 2016-08-22 | 2019-05-15 | Twist Bioscience Corp | De novo synthesized nucleic acid libraries |
JP6871364B2 (en) | 2016-09-21 | 2021-05-12 | ツイスト バイオサイエンス コーポレーション | Nucleic acid-based data storage |
KR20180064617A (en) | 2016-12-05 | 2018-06-15 | 삼성전자주식회사 | Storage device operating differently according to temperature of memory |
GB2573069A (en) | 2016-12-16 | 2019-10-23 | Twist Bioscience Corp | Variant libraries of the immunological synapse and synthesis thereof |
EP3577229A4 (en) | 2017-02-03 | 2020-12-23 | Codexis, Inc. | Engineered glycosyltransferases and steviol glycoside glucosylation methods |
NZ755628A (en) | 2017-02-13 | 2023-09-29 | Codexis Inc | Engineered phenylalanine ammonia lyase polypeptides |
WO2018156792A1 (en) | 2017-02-22 | 2018-08-30 | Twist Bioscience Corporation | Nucleic acid based data storage |
WO2018170169A1 (en) | 2017-03-15 | 2018-09-20 | Twist Bioscience Corporation | Variant libraries of the immunological synapse and synthesis thereof |
JP7045725B2 (en) | 2017-04-27 | 2022-04-01 | コデクシス, インコーポレイテッド | Ketoreductase polypeptides and polynucleotides |
CA3062550A1 (en) | 2017-05-08 | 2018-11-15 | Codexis, Inc. | Engineered ligase variants |
WO2018227182A2 (en) * | 2017-06-09 | 2018-12-13 | University Of Houston System | Force-modulated hybridization for visualizing nucleic acid length and function |
WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
CN111566209A (en) | 2017-06-12 | 2020-08-21 | 特韦斯特生物科学公司 | Seamless nucleic acid assembly method |
JP7122009B2 (en) | 2017-06-14 | 2022-08-19 | コデクシス, インコーポレイテッド | Engineered transaminase polypeptides for industrial biocatalysis |
US11643642B2 (en) | 2017-06-27 | 2023-05-09 | Codexis, Inc. | Penicillin-g acylases |
CA3066767A1 (en) | 2017-06-30 | 2019-01-03 | Codexis, Inc. | T7 rna polymerase variants |
KR20200023455A (en) | 2017-06-30 | 2020-03-04 | 코덱시스, 인코포레이티드 | T7 RNA Polymerase Variants |
CN109306322A (en) * | 2017-07-26 | 2019-02-05 | 上海之江生物科技股份有限公司 | Sample treatment and liquor removing workstation and its application |
SG11202002194UA (en) | 2017-09-11 | 2020-04-29 | Twist Bioscience Corp | Gpcr binding proteins and synthesis thereof |
DE102017216358A1 (en) | 2017-09-14 | 2019-03-14 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Device and method for determining a polarization state of an electromagnetic wave |
JP7404229B2 (en) * | 2017-09-14 | 2023-12-25 | ライフマイン セラピューティクス, インコーポレイテッド | Human therapeutic targets and their modulators |
CA3079613A1 (en) | 2017-10-20 | 2019-04-25 | Twist Bioscience Corporation | Heated nanowells for polynucleotide synthesis |
CN111511389A (en) | 2017-11-07 | 2020-08-07 | 科德克希思公司 | Transglutaminase variants |
CN107896153B (en) * | 2017-11-15 | 2020-02-21 | 中国联合网络通信集团有限公司 | Traffic package recommendation method and device based on mobile user internet surfing behavior |
AU2018373587B2 (en) * | 2017-11-24 | 2022-08-11 | Ricoh Company, Ltd. | Device, preparator's skill evaluating method, program, and device, and testing device performance evaluating method, program, and device |
WO2019103128A1 (en) * | 2017-11-24 | 2019-05-31 | Ricoh Company, Ltd. | Device, preparator's skill evaluating method, program, and device, and testing device performance evaluating method, program, and device |
US11015180B2 (en) | 2017-12-13 | 2021-05-25 | Codexis, Inc. | Carboxyesterase polypeptides for amide coupling |
CN112041438A (en) | 2018-01-04 | 2020-12-04 | 特韦斯特生物科学公司 | DNA-based digital information storage |
CN108318072B (en) * | 2018-01-24 | 2021-03-16 | 北京电子工程总体研究所 | State confirmation device before survey of electronic product based on sensor |
CN112218708B (en) * | 2018-05-15 | 2023-06-16 | 生物复制有限公司 | Microarray transducer |
CN112639130A (en) | 2018-05-18 | 2021-04-09 | 特韦斯特生物科学公司 | Polynucleotides, reagents and methods for nucleic acid hybridization |
US11439970B2 (en) * | 2018-05-22 | 2022-09-13 | Microsoft Technology Licensing, Llc | DNA manufacturing, storage, and access system |
WO2019236761A1 (en) * | 2018-06-06 | 2019-12-12 | Syngulon Sa | Engineering antimicrobial peptides |
WO2019241132A1 (en) | 2018-06-12 | 2019-12-19 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
US11093547B2 (en) * | 2018-06-19 | 2021-08-17 | Intel Corporation | Data storage based on encoded DNA sequences |
CA3103718A1 (en) | 2018-07-09 | 2020-01-16 | Codexis, Inc. | Engineered purine nucleoside phosphorylase variant enzymes |
SG11202012138XA (en) | 2018-07-09 | 2021-01-28 | Codexis Inc | Engineered galactose oxidase variant enzymes |
WO2020014048A1 (en) | 2018-07-09 | 2020-01-16 | Codexis, Inc. | Engineered deoxyribose-phosphate aldolases |
JP2021530216A (en) | 2018-07-09 | 2021-11-11 | コデクシス, インコーポレイテッド | Manipulated pantothenate kinase variant enzyme |
KR20210031933A (en) | 2018-07-09 | 2021-03-23 | 코덱시스, 인코포레이티드 | Engineered Phosphopentomutase Variant Enzyme |
CA3105916A1 (en) | 2018-07-12 | 2020-01-16 | Codexis, Inc. | Engineered phenylalanine ammonia lyase polypeptides |
KR20210040408A (en) | 2018-07-30 | 2021-04-13 | 코덱시스, 인코포레이티드 | Engineered glycosyltransferase and steviol glycoside glucosylation method |
EP3613855A1 (en) * | 2018-08-23 | 2020-02-26 | Clariant Produkte (Deutschland) GmbH | Method for the production of a nucleic acid library |
WO2020123002A2 (en) * | 2018-09-15 | 2020-06-18 | Tahereh Karimi | Molecular encoding and computing methods and systems therefor |
BR112021008186A2 (en) | 2018-10-29 | 2021-08-17 | Codexis, Inc. | engineered dna polymerase, polynucleotide sequence, expression vector, host cell, composition, high-throughput assay system, and, methods for producing a engineered dna polymerase polypeptide in a host cell and for determining high throughput fidelity of a dna polymerase. |
CN109283319B (en) * | 2018-11-09 | 2022-02-22 | 榆林市科学技术信息研究所 | Device for analyzing ore storage capacity and ore surveying method based on device |
SG11202105668PA (en) | 2018-12-14 | 2021-06-29 | Codexis Inc | Engineered tyrosine ammonia lyase |
US11249941B2 (en) * | 2018-12-21 | 2022-02-15 | Palo Alto Research Center Incorporated | Exabyte-scale data storage using sequence-controlled polymers |
SG11202109283UA (en) | 2019-02-26 | 2021-09-29 | Twist Bioscience Corp | Variant nucleic acid libraries for antibody optimization |
EP3930753A4 (en) | 2019-02-26 | 2023-03-29 | Twist Bioscience Corporation | Variant nucleic acid libraries for glp1 receptor |
WO2020257612A1 (en) | 2019-06-21 | 2020-12-24 | Twist Bioscience Corporation | Barcode-based nucleic acid sequence assembly |
MX2022001468A (en) | 2019-08-09 | 2022-07-19 | Nutcracker Therapeutics Inc | Methods and apparatuses for manufacturing for removing material from a therapeutic composition. |
JP2023521772A (en) | 2020-04-10 | 2023-05-25 | コデクシス, インコーポレイテッド | Engineered transaminase polypeptide |
EP4204552A1 (en) | 2020-08-28 | 2023-07-05 | Codexis, Inc. | Engineered amylase variants |
JP2023539632A (en) | 2020-08-28 | 2023-09-15 | コデクシス, インコーポレイテッド | Engineered protease variants |
CN112416433B (en) * | 2020-11-24 | 2023-01-17 | 中科寒武纪科技股份有限公司 | Data processing device, data processing method and related product |
US11898174B2 (en) | 2020-12-18 | 2024-02-13 | Codexis, Inc. | Engineered uridine phosphorylase variant enzymes |
CA3214975A1 (en) | 2021-04-02 | 2022-10-06 | Codexis, Inc. | Engineered cyclic gmp-amp synthase (cgas) variant enzymes |
IL305922A (en) | 2021-04-02 | 2023-11-01 | Codexis Inc | Engineered guanylate kinase variant enzymes |
US11913036B2 (en) | 2021-04-02 | 2024-02-27 | Codexis, Inc. | Engineered acetate kinase variant enzymes |
CN117120600A (en) | 2021-04-02 | 2023-11-24 | 科德克希思公司 | Engineered adenylate kinase variant enzymes |
CN116362552B (en) * | 2023-05-31 | 2023-09-05 | 江西省水利科学院(江西省大坝安全管理中心、江西省水资源管理中心) | Method for evaluating safety risk level of small reservoir |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997020078A1 (en) * | 1995-11-30 | 1997-06-05 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
WO1997031256A2 (en) * | 1996-02-09 | 1997-08-28 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
WO1998042832A1 (en) * | 1997-03-25 | 1998-10-01 | California Institute Of Technology | Recombination of polynucleotide sequences using random or defined primers |
WO1998054312A1 (en) * | 1997-05-28 | 1998-12-03 | Babraham Institute | Ribosome complexes as selection particles for in vitro display and evolution of proteins |
WO1999014373A1 (en) * | 1997-09-17 | 1999-03-25 | Yale University | Method for selection of insertion mutations |
WO1999019341A1 (en) * | 1997-10-10 | 1999-04-22 | President & Fellows Of Harvard College | Replica amplification of nucleic acid arrays |
US5965408A (en) * | 1996-07-09 | 1999-10-12 | Diversa Corporation | Method of DNA reassembly by interrupting synthesis |
WO1999058661A1 (en) * | 1998-05-08 | 1999-11-18 | Diatech Pty. Ltd. | Continuous in vitro evolution |
WO1999060170A1 (en) * | 1998-05-21 | 1999-11-25 | Hyseq, Inc. | Linear arrays of immobilized compounds and methods of using same |
WO2000018906A2 (en) * | 1998-09-29 | 2000-04-06 | Maxygen, Inc. | Shuffling of codon altered genes |
WO2000042559A1 (en) * | 1999-01-18 | 2000-07-20 | Maxygen, Inc. | Methods of populating data structures for use in evolutionary simulations |
Family Cites Families (96)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4591567A (en) * | 1982-04-21 | 1986-05-27 | California Institute Of Technology | Recombinant DNA screening system including fixed array replicator and support |
US4591587A (en) * | 1984-10-01 | 1986-05-27 | Merck & Co., Inc. | Cyclopropyl pyridine compounds useful as calcium channel blockers |
US5866363A (en) * | 1985-08-28 | 1999-02-02 | Pieczenik; George | Method and means for sorting and identifying biological information |
US5824469A (en) * | 1986-07-17 | 1998-10-20 | University Of Washington | Method for producing novel DNA sequences with biological activity |
US6270961B1 (en) * | 1987-04-01 | 2001-08-07 | Hyseq, Inc. | Methods and apparatus for DNA sequencing and DNA identification |
US5158875A (en) * | 1989-08-25 | 1992-10-27 | Amgen Inc. | Production of biologically active insulin-like growth factor i from high expression host cell systems |
US5645917A (en) * | 1991-04-25 | 1997-07-08 | Fuji Photo Film Co., Ltd. | Magnetic recording medium |
US5512463A (en) * | 1991-04-26 | 1996-04-30 | Eli Lilly And Company | Enzymatic inverse polymerase chain reaction library mutagenesis |
ATE278807T1 (en) * | 1992-02-19 | 2004-10-15 | New York Health Res Inst | NEW ARRANGEMENTS OF OLIGONUCLEOTIDES AND THEIR USE FOR SORTING, ISOLATION, SEQUENCING AND MANIPULATION OF NUCLEIC ACIDS |
DE69334152T2 (en) * | 1992-06-05 | 2008-03-13 | The Scripps Research Institute, La Jolla | Linked D protein and method for identifying receptor activity modulating compounds |
US5591646A (en) * | 1992-09-02 | 1997-01-07 | Arris Pharmaceutical | Method and apparatus for peptide synthesis and screening |
US5585275A (en) * | 1992-09-02 | 1996-12-17 | Arris Pharmaceutical Corporation | Pilot apparatus for peptide synthesis and screening |
US5503980A (en) * | 1992-11-06 | 1996-04-02 | Trustees Of Boston University | Positional sequencing by hybridization |
US20020048749A1 (en) * | 1998-04-15 | 2002-04-25 | Robert J. Lipshutz | Methods for polymorphism identifcation and profiling |
US6335160B1 (en) | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
US5605793A (en) * | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
US5837458A (en) * | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
US6165793A (en) * | 1996-03-25 | 2000-12-26 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
US5834252A (en) * | 1995-04-18 | 1998-11-10 | Glaxo Group Limited | End-complementary polymerase reaction |
US5928905A (en) * | 1995-04-18 | 1999-07-27 | Glaxo Group Limited | End-complementary polymerase reaction |
US6379897B1 (en) * | 2000-11-09 | 2002-04-30 | Nanogen, Inc. | Methods for gene expression monitoring on electronic microarrays |
US5514588A (en) * | 1994-12-13 | 1996-05-07 | Exxon Research And Engineering Company | Surfactant-nutrients for bioremediation of hydrocarbon contaminated soils and water |
GB9425380D0 (en) * | 1994-12-15 | 1995-02-15 | Nycomed Pharma As | Peptides |
US5712171A (en) * | 1995-01-20 | 1998-01-27 | Arqule, Inc. | Method of generating a plurality of chemical compounds in a spatially arranged array |
US6284459B1 (en) * | 1995-04-25 | 2001-09-04 | Discovery Partners International | Solid support matrices with memories and combinatorial libraries therefrom |
US5545531A (en) * | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
US5856174A (en) * | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
US6168948B1 (en) * | 1995-06-29 | 2001-01-02 | Affymetrix, Inc. | Miniaturized genetic analysis systems and methods |
US6057103A (en) * | 1995-07-18 | 2000-05-02 | Diversa Corporation | Screening for novel bioactivities |
US6030779A (en) * | 1995-07-18 | 2000-02-29 | Diversa Corporation | Screening for novel bioactivities |
US6168919B1 (en) * | 1996-07-17 | 2001-01-02 | Diversa Corporation | Screening methods for enzymes and enzyme kits |
US5958672A (en) * | 1995-07-18 | 1999-09-28 | Diversa Corporation | Protein activity screening of clones having DNA from uncultivated microorganisms |
US6004788A (en) * | 1995-07-18 | 1999-12-21 | Diversa Corporation | Enzyme kits and libraries |
US5962258A (en) * | 1995-08-23 | 1999-10-05 | Diversa Corporation | Carboxymethyl cellulase fromthermotoga maritima |
US5869242A (en) * | 1995-09-18 | 1999-02-09 | Myriad Genetics, Inc. | Mass spectrometry to assess DNA sequence polymorphisms |
US5859700A (en) * | 1995-11-22 | 1999-01-12 | Kairos Scientific, Inc. | High resolution imaging microscope (HIRIM) and uses thereof |
US5763263A (en) * | 1995-11-27 | 1998-06-09 | Dehlinger; Peter J. | Method and apparatus for producing position addressable combinatorial libraries |
US5939250A (en) * | 1995-12-07 | 1999-08-17 | Diversa Corporation | Production of enzymes having desired activities by mutagenesis |
US20030215798A1 (en) * | 1997-06-16 | 2003-11-20 | Diversa Corporation | High throughput fluorescence-based screening for novel enzymes |
US5830696A (en) * | 1996-12-05 | 1998-11-03 | Diversa Corporation | Directed evolution of thermophilic enzymes |
US5814473A (en) * | 1996-02-09 | 1998-09-29 | Diversa Corporation | Transaminases and aminotransferases |
US5962283A (en) * | 1995-12-07 | 1999-10-05 | Diversa Corporation | Transminases and amnotransferases |
US6238884B1 (en) * | 1995-12-07 | 2001-05-29 | Diversa Corporation | End selection in directed evolution |
US6171820B1 (en) * | 1995-12-07 | 2001-01-09 | Diversa Corporation | Saturation mutagenesis in directed evolution |
US20020150921A1 (en) * | 1996-02-09 | 2002-10-17 | Francis Barany | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
US5942430A (en) * | 1996-02-16 | 1999-08-24 | Diversa Corporation | Esterases |
US5958751A (en) * | 1996-03-08 | 1999-09-28 | Diversa Corporation | α-galactosidase |
US6096548A (en) * | 1996-03-25 | 2000-08-01 | Maxygen, Inc. | Method for directing evolution of a virus |
US5789228A (en) * | 1996-05-22 | 1998-08-04 | Diversa Corporation | Endoglucanases |
US5877001A (en) * | 1996-06-17 | 1999-03-02 | Diverso Corporation | Amidase |
US5763239A (en) * | 1996-06-18 | 1998-06-09 | Diversa Corporation | Production and use of normalized DNA libraries |
US5939300A (en) * | 1996-07-03 | 1999-08-17 | Diversa Corporation | Catalases |
JP2001505648A (en) * | 1996-07-05 | 2001-04-24 | ベックマン コールター インコーポレイテッド | Automatic sample processing system |
AU738328B2 (en) * | 1997-01-21 | 2001-09-13 | General Hospital Corporation, The | Selection of proteins using RNA-protein fusions |
CA2197624C (en) * | 1997-02-14 | 2003-07-29 | Robert J. Davies | Hybrid single sideband optical modulator |
US6291165B1 (en) * | 1997-03-18 | 2001-09-18 | Novo Nordisk A/S | Shuffling of heterologous DNA sequences |
US5852498A (en) | 1997-04-04 | 1998-12-22 | Kairos Scientific Inc. | Optical instrument having a variable optical filter |
US6180341B1 (en) * | 1997-05-01 | 2001-01-30 | Board Of Regents, The Universiry Of Texas System | In vitro scanning saturation mutagenesis of proteins |
US5948666A (en) * | 1997-08-06 | 1999-09-07 | Diversa Corporation | Isolation and identification of polymerases |
US5876997A (en) * | 1997-08-13 | 1999-03-02 | Diversa Corporation | Phytase |
WO1999011818A1 (en) * | 1997-08-28 | 1999-03-11 | Isao Karube | Method for detecting highly functional polypeptides or nucleic acids |
EP1538206B1 (en) * | 1997-09-16 | 2010-03-24 | Centocor, Inc. | Method for the complete chemical synthesis and assembly of genes and genomes |
US6322968B1 (en) * | 1997-11-21 | 2001-11-27 | Orchid Biosciences, Inc. | De novo or “universal” sequencing array |
US5945522A (en) * | 1997-12-22 | 1999-08-31 | Genset | Prostate cancer gene |
EP2189791A3 (en) * | 1998-02-04 | 2011-03-09 | Life Technologies Corporation | Microarrays and uses therefor |
US5914245A (en) * | 1998-04-20 | 1999-06-22 | Kairos Scientific Inc. | Solid phase enzyme kinetics screening in microcolonies |
US6287765B1 (en) * | 1998-05-20 | 2001-09-11 | Molecular Machines, Inc. | Methods for detecting and identifying single molecules |
US6406921B1 (en) * | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
US6403312B1 (en) * | 1998-10-16 | 2002-06-11 | Xencor | Protein design automatic for protein libraries |
AU2144000A (en) * | 1998-10-27 | 2000-05-15 | Affymetrix, Inc. | Complexity management and analysis of genomic dna |
US6159368A (en) * | 1998-10-29 | 2000-12-12 | The Perkin-Elmer Corporation | Multi-well microfiltration apparatus |
US6264891B1 (en) * | 1998-12-22 | 2001-07-24 | Eos Biotechnology, Inc. | Apparatus and method for concurrent chemical synthesis |
US20010055763A1 (en) * | 1998-12-24 | 2001-12-27 | Sharat Singh | Individually addressable solid surfaces for multiplexed operations |
US6917882B2 (en) * | 1999-01-19 | 2005-07-12 | Maxygen, Inc. | Methods for making character strings, polynucleotides and polypeptides having desired characteristics |
US6376246B1 (en) * | 1999-02-05 | 2002-04-23 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
US6368861B1 (en) * | 1999-01-19 | 2002-04-09 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
EP1165775A2 (en) * | 1999-03-05 | 2002-01-02 | Maxygen, Inc. | Recombination of insertion modified nucleic acids |
AU3623800A (en) * | 1999-03-08 | 2000-09-28 | Protogene Laboratories, Inc. | Methods and compositions for economically synthesizing and assembling long dna sequences |
US20020055099A1 (en) * | 1999-03-15 | 2002-05-09 | Paul B. Fisher | Sequential cdna library and uses thereof |
US6180351B1 (en) * | 1999-07-22 | 2001-01-30 | Agilent Technologies Inc. | Chemical array fabrication with identifier |
US6994972B2 (en) * | 1999-09-02 | 2006-02-07 | Corning Incorporated | Porous substrates for DNA arrays |
US6613516B1 (en) * | 1999-10-30 | 2003-09-02 | Affymetrix, Inc. | Preparation of nucleic acid samples |
US20020090649A1 (en) * | 1999-12-15 | 2002-07-11 | Tony Chan | High density column and row addressable electrode arrays |
AU2788101A (en) * | 2000-01-11 | 2001-07-24 | Maxygen, Inc. | Integrated systems and methods for diversity generation and screening |
AU2001240040A1 (en) * | 2000-03-03 | 2001-09-17 | California Institute Of Technology | Combinatorial array for nucleic acid analysis |
WO2001073119A2 (en) * | 2000-03-29 | 2001-10-04 | Cambia | Methods for genotyping by hybridization analysis |
US20010041349A1 (en) * | 2000-04-17 | 2001-11-15 | Andrew Patron | Protein expression system arrays and use in biological screening |
US6596490B2 (en) * | 2000-07-14 | 2003-07-22 | Applied Gene Technologies, Inc. | Nucleic acid hairpin probes and uses thereof |
US20020164634A1 (en) * | 2000-08-26 | 2002-11-07 | Perlegen Sciences, Inc. | Methods for reducing complexity of nucleic acid samples |
US20020055112A1 (en) * | 2000-08-26 | 2002-05-09 | Nila Patil | Methods for reducing complexity of nucleic acid samples |
JP2002071687A (en) * | 2000-08-31 | 2002-03-12 | Canon Inc | Screening method for variant gene |
EP1330306A2 (en) * | 2000-10-10 | 2003-07-30 | BioTrove, Inc. | Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof |
US6855501B2 (en) * | 2001-03-26 | 2005-02-15 | Linden Technologies, Inc. | Transfer of arrayed chemical compositions |
US6756202B2 (en) * | 2001-04-30 | 2004-06-29 | Agilent Technologies, Inc. | Reading multi-featured arrays |
US20050084907A1 (en) | 2002-03-01 | 2005-04-21 | Maxygen, Inc. | Methods, systems, and software for identifying functional biomolecules |
US20090312196A1 (en) | 2008-06-13 | 2009-12-17 | Codexis, Inc. | Method of synthesizing polynucleotide variants |
-
2001
- 2001-01-10 AU AU27881/01A patent/AU2788101A/en not_active Abandoned
- 2001-01-10 IL IL15029101A patent/IL150291A0/en unknown
- 2001-01-10 WO PCT/US2001/001056 patent/WO2001051663A2/en not_active Application Discontinuation
- 2001-01-10 US US09/760,010 patent/US20010039014A1/en not_active Abandoned
- 2001-01-10 CA CA002396320A patent/CA2396320A1/en not_active Abandoned
- 2001-01-10 JP JP2001551237A patent/JP2003519495A/en active Pending
- 2001-01-10 SG SG200406111A patent/SG121902A1/en unknown
- 2001-01-10 EP EP01902036A patent/EP1276900A2/en not_active Withdrawn
-
2002
- 2002-05-23 US US10/155,739 patent/US20030064393A1/en not_active Abandoned
- 2002-05-23 US US10/154,936 patent/US7462469B2/en not_active Expired - Fee Related
- 2002-05-23 US US10/154,939 patent/US20030054384A1/en not_active Abandoned
-
2007
- 2007-02-21 US US11/677,505 patent/US8014961B2/en not_active Expired - Fee Related
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997020078A1 (en) * | 1995-11-30 | 1997-06-05 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
WO1997031256A2 (en) * | 1996-02-09 | 1997-08-28 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
US5965408A (en) * | 1996-07-09 | 1999-10-12 | Diversa Corporation | Method of DNA reassembly by interrupting synthesis |
WO1998042832A1 (en) * | 1997-03-25 | 1998-10-01 | California Institute Of Technology | Recombination of polynucleotide sequences using random or defined primers |
WO1998054312A1 (en) * | 1997-05-28 | 1998-12-03 | Babraham Institute | Ribosome complexes as selection particles for in vitro display and evolution of proteins |
WO1999014373A1 (en) * | 1997-09-17 | 1999-03-25 | Yale University | Method for selection of insertion mutations |
WO1999019341A1 (en) * | 1997-10-10 | 1999-04-22 | President & Fellows Of Harvard College | Replica amplification of nucleic acid arrays |
WO1999058661A1 (en) * | 1998-05-08 | 1999-11-18 | Diatech Pty. Ltd. | Continuous in vitro evolution |
WO1999060170A1 (en) * | 1998-05-21 | 1999-11-25 | Hyseq, Inc. | Linear arrays of immobilized compounds and methods of using same |
WO2000018906A2 (en) * | 1998-09-29 | 2000-04-06 | Maxygen, Inc. | Shuffling of codon altered genes |
WO2000042559A1 (en) * | 1999-01-18 | 2000-07-20 | Maxygen, Inc. | Methods of populating data structures for use in evolutionary simulations |
Non-Patent Citations (2)
Title |
---|
MOORE J C ET AL: "STRATEGIES FOR THE IN VITRO EVOLUTION OF PROTEIN FUNCTION: ENZYME EVOLUTION BY RANDOM RECOMBINATION OF IMPROVED SEQUENCES", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 272, no. 3, 26 September 1997 (1997-09-26), pages 336 - 347, XP000892797, ISSN: 0022-2836 * |
ZHAO H ET AL: "FUNCTIONAL AND NONFUNCTIONAL MUTATIONS DISTINGUISHED BY RANDOM RECOMBINATION OF HOMOLOGOUS GENES", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 94, July 1997 (1997-07-01), pages 7997 - 8000, XP002916918, ISSN: 0027-8424 * |
Also Published As
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EP1276900A2 (en) | 2003-01-22 |
IL150291A0 (en) | 2002-12-01 |
CA2396320A1 (en) | 2001-07-19 |
US7462469B2 (en) | 2008-12-09 |
US8014961B2 (en) | 2011-09-06 |
SG121902A1 (en) | 2006-05-26 |
WO2001051663A2 (en) | 2001-07-19 |
AU2788101A (en) | 2001-07-24 |
US20010039014A1 (en) | 2001-11-08 |
US20030064393A1 (en) | 2003-04-03 |
US20030054384A1 (en) | 2003-03-20 |
US20080015116A1 (en) | 2008-01-17 |
US20030054383A1 (en) | 2003-03-20 |
JP2003519495A (en) | 2003-06-24 |
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