WO2001055704A8 - System for transferring fluid samples through a sensor array - Google Patents

System for transferring fluid samples through a sensor array

Info

Publication number
WO2001055704A8
WO2001055704A8 PCT/US2001/003316 US0103316W WO0155704A8 WO 2001055704 A8 WO2001055704 A8 WO 2001055704A8 US 0103316 W US0103316 W US 0103316W WO 0155704 A8 WO0155704 A8 WO 0155704A8
Authority
WO
WIPO (PCT)
Prior art keywords
sensor array
fluid samples
analyte
transferring fluid
cavities
Prior art date
Application number
PCT/US2001/003316
Other languages
French (fr)
Other versions
WO2001055704A1 (en
Inventor
John T Mcdevitt
Eric V Anslyn
Jason B Shear
Dean P Neikirk
Young-Soo Sohn
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Priority to AU2001238011A priority Critical patent/AU2001238011A1/en
Publication of WO2001055704A1 publication Critical patent/WO2001055704A1/en
Publication of WO2001055704A8 publication Critical patent/WO2001055704A8/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6452Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02Burettes; Pipettes
    • B01L3/0289Apparatus for withdrawing or distributing predetermined quantities of fluid
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251Colorimeters; Construction thereof
    • G01N21/253Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6452Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G01N21/6454Individual samples arranged in a regular 2D-array, e.g. multiwell plates using an integrated detector array
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6486Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00497Features relating to the solid phase supports
    • B01J2219/005Beads
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/0054Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572Chemical means
    • B01J2219/00576Chemical means fluorophore
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00646Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports
    • B01J2219/00648Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports by the use of solid beads
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00659Two-dimensional arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00702Processes involving means for analysing and characterising the products
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/0072Organic compounds
    • B01J2219/00722Nucleotides
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/026Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0647Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0657Pipetting powder
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0647Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668Trapping microscopic beads
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12Specific details about manufacturing devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0627Sensor or part of a sensor is integrated
    • B01L2300/0636Integrated biosensor, microarrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B01L2400/049Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0633Valves, specific forms thereof with moving parts
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0633Valves, specific forms thereof with moving parts
    • B01L2400/0638Valves, specific forms thereof with moving parts membrane valves, flap valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11Compounds covalently bound to a solid support
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/02Devices for withdrawing samples
    • G01N2001/021Correlating sampling sites with geographical information, e.g. GPS
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N2021/6417Spectrofluorimetric devices
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N2021/6417Spectrofluorimetric devices
    • G01N2021/6421Measuring at two or more wavelengths
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6432Quenching
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G01N2021/6441Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N2021/6482Sample cells, cuvettes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099Characterised by type of test elements
    • G01N2035/00158Elements containing microarrays, i.e. "biochip"
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465Separating and mixing arrangements
    • G01N2035/00564Handling or washing solid phase elements, e.g. beads
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6456Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458Fluorescence microscopy
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00Features of devices classified in G01N21/00
    • G01N2201/06Illumination; Optics
    • G01N2201/062LED's
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00Features of devices classified in G01N21/00
    • G01N2201/06Illumination; Optics
    • G01N2201/062LED's
    • G01N2201/0627Use of several LED's for spectral resolution
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/924Specified use of nanostructure for medical, immunological, body treatment, or diagnosis using nanostructure as support of dna analysis
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575Volumetric liquid transfer

Abstract

A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.
PCT/US2001/003316 2000-01-31 2001-01-31 System for transferring fluid samples through a sensor array WO2001055704A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001238011A AU2001238011A1 (en) 2000-01-31 2001-01-31 System for transferring fluid samples through a sensor array

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US17942400P 2000-01-31 2000-01-31
US17929400P 2000-01-31 2000-01-31
US17938000P 2000-01-31 2000-01-31
US17936900P 2000-01-31 2000-01-31
US17929300P 2000-01-31 2000-01-31
US17929200P 2000-01-31 2000-01-31
US60/179,424 2000-01-31
US60/179,293 2000-01-31
US60/179,380 2000-01-31
US60/179,292 2000-01-31
US60/179,294 2000-01-31
US60/179,369 2000-01-31

Publications (2)

Publication Number Publication Date
WO2001055704A1 WO2001055704A1 (en) 2001-08-02
WO2001055704A8 true WO2001055704A8 (en) 2001-12-06

Family

ID=27558697

Family Applications (5)

Application Number Title Priority Date Filing Date
PCT/US2001/003139 WO2001055701A1 (en) 2000-01-31 2001-01-31 System and method for the analysis of bodily fluids
PCT/US2001/003241 WO2001055703A1 (en) 2000-01-31 2001-01-31 Method of preparing a sensor array
PCT/US2001/003240 WO2001055702A1 (en) 2000-01-31 2001-01-31 Portable sensor array system
PCT/US2001/003141 WO2001055952A2 (en) 2000-01-31 2001-01-31 Method and system for collecting and transmitting chemical information
PCT/US2001/003316 WO2001055704A1 (en) 2000-01-31 2001-01-31 System for transferring fluid samples through a sensor array

Family Applications Before (4)

Application Number Title Priority Date Filing Date
PCT/US2001/003139 WO2001055701A1 (en) 2000-01-31 2001-01-31 System and method for the analysis of bodily fluids
PCT/US2001/003241 WO2001055703A1 (en) 2000-01-31 2001-01-31 Method of preparing a sensor array
PCT/US2001/003240 WO2001055702A1 (en) 2000-01-31 2001-01-31 Portable sensor array system
PCT/US2001/003141 WO2001055952A2 (en) 2000-01-31 2001-01-31 Method and system for collecting and transmitting chemical information

Country Status (7)

Country Link
US (8) US6713298B2 (en)
EP (2) EP2230314A1 (en)
AT (1) ATE403145T1 (en)
AU (5) AU2001234709A1 (en)
CA (1) CA2401782A1 (en)
DE (1) DE60135092D1 (en)
WO (5) WO2001055701A1 (en)

Families Citing this family (487)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8198096B2 (en) * 1998-05-05 2012-06-12 Massachusetts Institute Of Technology Emissive polymers and devices incorporating these polymers
US20050147534A1 (en) * 1998-05-05 2005-07-07 Massachusetts Institute Of Technology Emissive sensors and devices incorporating these sensors
ATE261483T1 (en) * 1998-05-05 2004-03-15 Massachusetts Inst Technology LIGHT EMITTING POLYMERS AND DEVICES CONTAINING SAME
US6908770B1 (en) * 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
JP3486557B2 (en) * 1998-07-30 2004-01-13 宮崎沖電気株式会社 Transfer molding apparatus and semiconductor device manufacturing method
US6978212B1 (en) * 1999-11-01 2005-12-20 Smiths Detection Inc. System for portable sensing
US6975924B2 (en) * 1999-12-03 2005-12-13 Baxter International Inc. Method and apparatus for controlling the strategy of compounding pharmaceutical admixtures
DE60135092D1 (en) * 2000-01-31 2008-09-11 Univ Texas PORTABLE DEVICE WITH A SENSOR ARRAY ARRANGEMENT
EP1196841A2 (en) * 2000-03-09 2002-04-17 Koninklijke Philips Electronics N.V. A family of complex systems with shared family software architecture
US7624172B1 (en) 2000-03-17 2009-11-24 Aol Llc State change alerts mechanism
US9246975B2 (en) 2000-03-17 2016-01-26 Facebook, Inc. State change alerts mechanism
WO2001072002A2 (en) 2000-03-17 2001-09-27 America Online, Inc. Shared groups rostering system
WO2001078652A2 (en) 2000-04-14 2001-10-25 Metabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
US7329489B2 (en) 2000-04-14 2008-02-12 Matabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
SE0001790D0 (en) * 2000-05-12 2000-05-12 Aamic Ab Hydrophobic barrier
IL153545A0 (en) * 2000-07-07 2003-07-06 Bristol Myers Squibb Co Apparatus for measuring cellular electrical activity
RU2278612C2 (en) * 2000-07-14 2006-06-27 Лайфскен, Инк. Immune sensor
AU785424B2 (en) * 2000-07-26 2007-05-17 Regents Of The University Of California, The Manipulation of live cells and inorganic objects with optical micro beam arrays
GB2366011B (en) * 2000-08-14 2004-10-13 Biotrace Ltd Data processing system
US6778724B2 (en) * 2000-11-28 2004-08-17 The Regents Of The University Of California Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices
WO2002044689A2 (en) * 2000-11-28 2002-06-06 The Regents Of The University Of California Storing microparticles in optical switch which is transported by micro-fluidic device
EP1373874A4 (en) * 2001-01-31 2004-03-31 Univ Texas Method and apparatus for the confinement of materials in a micromachined chemical sensor array
US7425453B1 (en) * 2001-03-14 2008-09-16 The United States Of America As Represented By The Secretary Of The Navy Integrated circuit porphyrin-based optical Fabry-Perot chemical sensor
DE10117275B4 (en) * 2001-04-06 2005-02-24 Hte Ag The High Throughput Experimentation Company Device for archiving and analyzing materials
US20040132166A1 (en) * 2001-04-10 2004-07-08 Bioprocessors Corp. Determination and/or control of reactor environmental conditions
US20050032204A1 (en) * 2001-04-10 2005-02-10 Bioprocessors Corp. Microreactor architecture and methods
US20040058407A1 (en) * 2001-04-10 2004-03-25 Miller Scott E. Reactor systems having a light-interacting component
DE10123259A1 (en) * 2001-05-12 2002-11-21 Eppendorf Ag Microfluidic storage and / or dosing component
EP1277438A1 (en) * 2001-07-10 2003-01-22 Agilent Technologies, Inc. (a Delaware corporation) System for point of care diagnosis and/or analysis
US20040146917A1 (en) * 2001-08-03 2004-07-29 Nanosphere, Inc. Nanoparticle imaging system and method
NZ531212A (en) * 2001-08-03 2006-01-27 Nanosphere Inc Nanoparticle imaging system and method
US7253003B2 (en) * 2001-10-19 2007-08-07 Wisconsin Alumni Research Foundation Method for monitoring the environment within a microfluidic device
US7322474B2 (en) * 2001-10-22 2008-01-29 Mcneil-Ppc, Inc. Interactive product selection system
US7304259B2 (en) 2001-11-01 2007-12-04 Siemens Energy & Automation, Inc. Mail processing system with multilevel contaminant detection and sterilization
EP1452986A4 (en) * 2001-11-05 2006-08-16 Daikin Ind Ltd Sanitary measurement system
US20030087455A1 (en) * 2001-11-07 2003-05-08 Eggers Mitchell D Sample carrier system
US7584240B2 (en) 2001-11-07 2009-09-01 Genvault Corporation Automated biological sample archive for storage, retrieval and analysis of large numbers of samples for remote clients
US6989891B2 (en) * 2001-11-08 2006-01-24 Optiscan Biomedical Corporation Device and method for in vitro determination of analyte concentrations within body fluids
US7232691B2 (en) * 2001-11-27 2007-06-19 Los Alamos National Security, Llc Bioassay and biomolecular identification, sorting, and collection methods using magnetic microspheres
US7462325B2 (en) * 2001-11-30 2008-12-09 Nomadics, Inc. Luminescent polymer particles
US20030113730A1 (en) * 2001-12-18 2003-06-19 Daquino Lawrence J. Pulse jet print head having multiple printhead dies and methods for use in the manufacture of biopolymeric arrays
US7054759B2 (en) * 2001-12-27 2006-05-30 Arkray, Inc Concentration measuring method
US7169107B2 (en) * 2002-01-25 2007-01-30 Karen Jersey-Willuhn Conductivity reconstruction based on inverse finite element measurements in a tissue monitoring system
JP3721334B2 (en) * 2002-02-01 2005-11-30 富士写真フイルム株式会社 Receptor-ligand association reaction method and reactor used therefor
US20080172026A1 (en) 2006-10-17 2008-07-17 Blomquist Michael L Insulin pump having a suspension bolus
US7892420B2 (en) * 2004-08-03 2011-02-22 Dornoch Medical Systems, Inc. High volume liquid waste collection and disposal system
US20060134713A1 (en) * 2002-03-21 2006-06-22 Lifescan, Inc. Biosensor apparatus and methods of use
US7057724B1 (en) * 2002-03-21 2006-06-06 Institute Of Critical Care Medicine Particulate info to field units
US20120078075A1 (en) * 2002-04-04 2012-03-29 Maynard John D Determination of a measure of a glycation end-product or disease state using tissue fluorescence in combination with one or more other tests
US20050026134A1 (en) * 2002-04-10 2005-02-03 Bioprocessors Corp. Systems and methods for control of pH and other reactor environment conditions
US9943847B2 (en) 2002-04-17 2018-04-17 Cytonome/St, Llc Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
AU2003228711C1 (en) * 2002-04-26 2010-01-07 Board Of Regents, The University Of Texas System Method and system for the detection of cardiac risk factors
US20050055242A1 (en) * 2002-04-30 2005-03-10 Bryan Bello System and method for medical data tracking, analysis and reporting for healthcare system
US20030215369A1 (en) * 2002-05-17 2003-11-20 Eggers Mitchell D. Sample carrier receiver
EP1364613A1 (en) * 2002-05-23 2003-11-26 FESTO AG & Co Device for health examination and monitoring
US7776195B2 (en) * 2002-05-28 2010-08-17 Autogenomics, Inc. Integrated sample processing platform
US20070275411A1 (en) 2006-05-25 2007-11-29 Mcgall Glenn H Silane mixtures
US7332273B2 (en) 2002-06-20 2008-02-19 Affymetrix, Inc. Antireflective coatings for high-resolution photolithographic synthesis of DNA arrays
US20030003587A1 (en) * 2002-06-28 2003-01-02 Murray George M Molecularly imprinted polymer based sensors for the detection of narcotics
WO2004007634A2 (en) * 2002-07-15 2004-01-22 Massachusetts Institute Of Technology Emissive, high charge transport polymers
WO2004009840A1 (en) * 2002-07-24 2004-01-29 Board Of Regents, The University Of Texas System Capture and detection of microbes by membrane methods
US7867754B1 (en) 2002-08-01 2011-01-11 Purdue Research Foundation Microarrays for analyte detection
US7455770B2 (en) * 2002-09-09 2008-11-25 Cytonome, Inc. Implementation of microfluidic components in a microfluidic system
EP1539921B1 (en) * 2002-09-16 2007-11-21 Pan-Biotech GmbH Device for culturing cells, particularly human or animal cells
ATE376052T1 (en) * 2002-09-16 2007-11-15 Pan Biotech Gmbh CELL CULTURE CHAMBER FOR A CELL CULTURE SYSTEM
US7635575B2 (en) * 2002-09-16 2009-12-22 Pan-Biotech Gmbh Method for cultivating cells, particularly human or animal cells
ITTO20020808A1 (en) * 2002-09-17 2004-03-18 St Microelectronics Srl INTEGRATED DNA ANALYSIS DEVICE.
US7964390B2 (en) * 2002-10-11 2011-06-21 Case Western Reserve University Sensor system
US7122384B2 (en) * 2002-11-06 2006-10-17 E. I. Du Pont De Nemours And Company Resonant light scattering microparticle methods
US7899862B2 (en) 2002-11-18 2011-03-01 Aol Inc. Dynamic identification of other users to an online user
US8122137B2 (en) 2002-11-18 2012-02-21 Aol Inc. Dynamic location of a subordinate user
US8701014B1 (en) 2002-11-18 2014-04-15 Facebook, Inc. Account linking
US8965964B1 (en) 2002-11-18 2015-02-24 Facebook, Inc. Managing forwarded electronic messages
US8005919B2 (en) 2002-11-18 2011-08-23 Aol Inc. Host-based intelligent results related to a character stream
US7640306B2 (en) 2002-11-18 2009-12-29 Aol Llc Reconfiguring an electronic message to effect an enhanced notification
US7428580B2 (en) 2003-11-26 2008-09-23 Aol Llc Electronic message forwarding
WO2004046867A2 (en) 2002-11-18 2004-06-03 America Online, Inc. People lists
US7590696B1 (en) 2002-11-18 2009-09-15 Aol Llc Enhanced buddy list using mobile device identifiers
AU2003304256A1 (en) * 2002-11-20 2005-01-13 Laser Light Technologies, Inc. An online flow through microchip for detecting hazardous chemical and biological agents in drinking water
US7718442B2 (en) * 2002-11-22 2010-05-18 Genvault Corporation Sealed sample storage element system and method
EP1578896A4 (en) * 2002-11-25 2009-11-11 Univ Tufts Electro-optical nucleic acid-based sensor array and method for detecting analytes
US7062385B2 (en) * 2002-11-25 2006-06-13 Tufts University Intelligent electro-optical nucleic acid-based sensor array and method for detecting volatile compounds in ambient air
US20040106114A1 (en) * 2002-12-02 2004-06-03 Eastman Kodak Company Simplified detection process for colored bead random microarrays
US20040121337A1 (en) * 2002-12-19 2004-06-24 Nomadics, Inc. Luminescent polymers and methods of use thereof
WO2004083806A2 (en) 2003-01-22 2004-09-30 University Of South Florida Autonomous genosensor apparatus and methods for use
US7125727B2 (en) * 2003-01-29 2006-10-24 Protedyne Corporation Sample handling tool with piezoelectric actuator
AU2004212464A1 (en) * 2003-02-05 2004-08-26 Board Of Regents, The University Of Texas System A microchip-based system for HIV diagnostics
EP1590659A4 (en) * 2003-02-07 2010-04-21 Univ Texas Multi-shell microspheres with integrated chomatographic and detection layers for use in array sensors
US20040162844A1 (en) * 2003-02-13 2004-08-19 J. J. Keller & Associates, Inc. Driver management system and method
US7603417B2 (en) 2003-03-26 2009-10-13 Aol Llc Identifying and using identities deemed to be known to a user
US20050064452A1 (en) * 2003-04-25 2005-03-24 Schmid Matthew J. System and method for the detection of analytes
US20100075858A1 (en) * 2003-04-29 2010-03-25 Genvault Corporation Biological bar code
US9317922B2 (en) 2003-05-16 2016-04-19 Board Of Regents The University Of Texas System Image and part recognition technology
US7651850B2 (en) 2003-05-16 2010-01-26 Board Of Regents, The University Of Texas System Image and part recognition technology
US20040241880A1 (en) * 2003-05-30 2004-12-02 Leproust Eric M. Ligand array assays having reduced fluorescent dye degradation and compositions for practicing the same
US7860727B2 (en) * 2003-07-17 2010-12-28 Ventana Medical Systems, Inc. Laboratory instrumentation information management and control network
US8719053B2 (en) * 2003-07-17 2014-05-06 Ventana Medical Systems, Inc. Laboratory instrumentation information management and control network
US7653693B2 (en) 2003-09-05 2010-01-26 Aol Llc Method and system for capturing instant messages
US7298478B2 (en) 2003-08-14 2007-11-20 Cytonome, Inc. Optical detector for a particle sorting system
NZ580449A (en) * 2003-09-11 2011-06-30 Theranos Inc Ingestible medical device with biocompatible polymer coating, device with microarray to interact with disease marker
US7198855B2 (en) * 2003-09-12 2007-04-03 Becton, Dickinson And Company Methods of surface modification of a flexible substrate to enhance cell adhesion
WO2005031163A1 (en) * 2003-09-25 2005-04-07 Cytonome, Inc. Implementation of microfluidic components in a microfluidic system
US7524464B2 (en) 2003-09-26 2009-04-28 Ahn Chong H Smart disposable plastic lab-on-a-chip for point-of-care testing
JP4334969B2 (en) * 2003-10-02 2009-09-30 パナソニック株式会社 Blood component analysis sensor
US7121647B2 (en) * 2003-10-03 2006-10-17 Lexmark International, Inc. Method of applying an encapsulant material to an ink jet printhead
US7159974B2 (en) * 2003-10-06 2007-01-09 Lexmark International, Inc. Semipermeable membrane for an ink reservoir and method of attaching the same
US7582485B2 (en) * 2003-10-16 2009-09-01 Kimberly-Clark Worldride, Inc. Method and device for detecting ammonia odors and helicobacter pylori urease infection
US20100104473A1 (en) * 2003-11-06 2010-04-29 Kirollos Salama Kirollos Air sampling system and method for calibration
US20050100483A1 (en) * 2003-11-12 2005-05-12 Cytyc Corporation Specimen filter container having data storage
CA2545653C (en) * 2003-11-21 2014-07-08 Anp Technologies, Inc. Asymmetrically branched polymer conjugates and microarray assays
US7382004B2 (en) * 2003-11-25 2008-06-03 Sensor Electronic Technology, Inc. Semiconductor sensing device
US7651868B2 (en) 2003-12-11 2010-01-26 The Board Of Regents Of The University Of Texas System Method and system for the analysis of saliva using a sensor array
US7122799B2 (en) * 2003-12-18 2006-10-17 Palo Alto Research Center Incorporated LED or laser enabled real-time PCR system and spectrophotometer
WO2005069738A2 (en) * 2004-01-27 2005-08-04 Ramot At Tel Aviv University Ltd. Populations of cells and devices and systems including same
US7276389B2 (en) * 2004-02-25 2007-10-02 Samsung Electronics Co., Ltd. Article comprising metal oxide nanostructures and method for fabricating such nanostructures
US7465210B2 (en) * 2004-02-25 2008-12-16 The Regents Of The University Of California Method of fabricating carbide and nitride nano electron emitters
US20060257991A1 (en) * 2004-02-27 2006-11-16 Mcdevitt John T Integration of fluids and reagents into self-contained cartridges containing particle-based sensor elements and membrane-based sensor elements
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
US8105849B2 (en) 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
CN1690120A (en) * 2004-03-01 2005-11-02 三菱瓦斯化学株式会社 Resin compositions with high vibration damping ability
US7402425B2 (en) * 2004-03-02 2008-07-22 The Charles Stark Draper Laboratory, Inc. Stress-based electrostatic monitoring of chemical reactions and binding
US20050200487A1 (en) * 2004-03-06 2005-09-15 O'donnell Ryan Methods and devices for monitoring the distance between members of a group
TWI233637B (en) * 2004-03-17 2005-06-01 Promos Technologies Inc Method of correcting lithography process and method of forming overlay mark
US7187286B2 (en) * 2004-03-19 2007-03-06 Applera Corporation Methods and systems for using RFID in biological field
US20050216291A1 (en) * 2004-06-16 2005-09-29 Shaheen Elias A Complete mold system
US7230520B2 (en) * 2004-05-03 2007-06-12 Dell Products L.P. Method and apparatus for RF access to system ID and fault information
US7887750B2 (en) * 2004-05-05 2011-02-15 Bayer Healthcare Llc Analytical systems, devices, and cartridges therefor
WO2005116081A2 (en) 2004-05-24 2005-12-08 Genvault Corporation Stable protein storage and stable nucleic acid storage in recoverable form
EP1765487A1 (en) * 2004-06-07 2007-03-28 Bioprocessors Corporation Reactor mixing
US20050271560A1 (en) * 2004-06-07 2005-12-08 Bioprocessors Corp. Gas control in a reactor
WO2005121310A2 (en) * 2004-06-07 2005-12-22 Bioprocessors Corp. Creation of shear in a reactor
US7910531B2 (en) * 2004-06-17 2011-03-22 C2C Technologies Llc Composition and method for producing colored bubbles
US20050287536A1 (en) * 2004-06-24 2005-12-29 Douglas Kozlay Disposable, multi-use, DNA sample collection disk apparatus for field biohazard testing, DNA testing, and personal authentication
WO2006004739A2 (en) 2004-06-29 2006-01-12 Dako Denmark A/S Method of pre-treatment and staining of and support device for a biological sample
US7404613B2 (en) * 2004-06-30 2008-07-29 Lexmark International, Inc. Inkjet print cartridge having an adhesive with improved dimensional control
US20060008919A1 (en) * 2004-07-09 2006-01-12 Boay Yoke P Method and apparatus for detecting gas/radiation that employs color change detection mechanism
US8617819B2 (en) * 2004-09-17 2013-12-31 Massachusetts Institute Of Technology Polymers for analyte detection
WO2007001378A2 (en) * 2004-09-20 2007-01-04 Boston Microfluidics Microfluidic device for detecting soluble molecules
US20060067650A1 (en) * 2004-09-27 2006-03-30 Clarence Chui Method of making a reflective display device using thin film transistor production techniques
JP2008518405A (en) * 2004-10-21 2008-05-29 ファーマ ダイアグノスティックス エヌ.ヴィ. Stable metal / conductive polymer composite colloids and methods for making and using the same
US7361315B2 (en) * 2004-10-26 2008-04-22 Konica Minolta Medical & Graphic, Inc. Micro-reactor for biological substance inspection and biological substance inspection device
KR20070083810A (en) * 2004-10-28 2007-08-24 가부시키가이샤 심스 Disease diagnosing system
DE102004056735A1 (en) * 2004-11-09 2006-07-20 Clondiag Chip Technologies Gmbh Device for performing and analyzing microarray experiments
EP1838145B1 (en) * 2004-11-17 2016-03-09 GT Acquisition Sub, Inc. Radio frequency animal tracking system
US20070103314A1 (en) * 2004-11-17 2007-05-10 Geissler Randolph K Radio frequency animal tracking system
HU226650B1 (en) * 2004-11-30 2009-05-28 Vils Ag H System for detecting damage of a coating or/and inner side coated wall bordering a room suitable for containing material and method for producing thereof
US9260693B2 (en) 2004-12-03 2016-02-16 Cytonome/St, Llc Actuation of parallel microfluidic arrays
ZA200704952B (en) 2004-12-03 2008-11-26 Cytonome Inc Unitary cartridge for particle processing
GB2420850A (en) * 2004-12-03 2006-06-07 Orion Diagnostica Oy Particle based binding assay
US7879764B2 (en) 2004-12-28 2011-02-01 Intel Corporation Electrically active combinatorial chemical (EACC) chip for biochemical analyte detection
US20060141421A1 (en) * 2004-12-28 2006-06-29 Kimberly-Clark Worldwide, Inc. System and method for detecting substances related to oral health
US9182480B2 (en) * 2005-01-28 2015-11-10 Hewlett-Packard Development Company, L.P. Information technology (IT) equipment positioning system
US7910356B2 (en) 2005-02-01 2011-03-22 Purdue Research Foundation Multiplexed biological analyzer planar array apparatus and methods
US7405831B2 (en) 2005-02-01 2008-07-29 Purdue Research Foundation Laser scanning interferometric surface metrology
US20070023643A1 (en) 2005-02-01 2007-02-01 Nolte David D Differentially encoded biological analyzer planar array apparatus and methods
US8251907B2 (en) 2005-02-14 2012-08-28 Optiscan Biomedical Corporation System and method for determining a treatment dose for a patient
US7907985B2 (en) 2005-02-14 2011-03-15 Optiscan Biomedical Corporation Fluid handling cassette with a fluid control interface and sample separator
US20070103678A1 (en) * 2005-02-14 2007-05-10 Sterling Bernhard B Analyte detection system with interferent identification and correction
US8936755B2 (en) 2005-03-02 2015-01-20 Optiscan Biomedical Corporation Bodily fluid composition analyzer with disposable cassette
US20060183261A1 (en) * 2005-02-15 2006-08-17 Dudenhoefer Christie L Method of forming a biological sensor
WO2006102258A2 (en) * 2005-03-21 2006-09-28 Utah State University Particle sorting by fluidic vectoring
US20060257439A1 (en) * 2005-03-29 2006-11-16 Sabnis Ram W Cleansing compositions with color changing indicator
WO2006110347A2 (en) * 2005-03-29 2006-10-19 The Trustees Of The University Of Pennsylvania Single walled carbon nanotubes functionally adsorbed to biopolymers for use as chemical sensors
US20060236470A1 (en) * 2005-03-29 2006-10-26 Sabnis Ram W Novelty compositions with color changing indicator
WO2008097261A2 (en) * 2006-07-13 2008-08-14 The Trustees Of The University Of Pennsylvania Single walled carbon nanotubes with functionally adsorbed biopolymers for use as chemical sensors
US20060222675A1 (en) * 2005-03-29 2006-10-05 Sabnis Ram W Personal care compositions with color changing indicator
US20060222601A1 (en) * 2005-03-29 2006-10-05 Sabnis Ram W Oral care compositions with color changing indicator
US7682816B2 (en) * 2005-04-07 2010-03-23 454 Life Sciences Corporation Thin film coated microwell arrays and methods of using same
US20100245803A1 (en) * 2005-04-12 2010-09-30 Chromedx Inc. Blood sample holder for spectroscopic analysis
CA2507323A1 (en) * 2005-05-13 2006-11-13 Chromedx Inc. Diagnostic whole blood and plasma apparatus
US8206650B2 (en) * 2005-04-12 2012-06-26 Chromedx Inc. Joint-diagnostic spectroscopic and biosensor meter
CA2517299A1 (en) * 2005-08-26 2007-02-26 Chromedx Inc. Hollow needle assembly
US7740804B2 (en) * 2005-04-12 2010-06-22 Chromedx Inc. Spectroscopic sample holder
EP1717585B1 (en) * 2005-04-28 2013-01-16 FUJIFILM Corporation Microchip and analysis method using the same
KR101381331B1 (en) 2005-05-09 2014-04-04 테라노스, 인코포레이티드 Point-of-care fluidic systems and uses thereof
JP2006322841A (en) * 2005-05-19 2006-11-30 Shimadzu Corp Spectrometry and spectrophotometer
US8076143B2 (en) * 2005-05-25 2011-12-13 Westfall Geofrey J Method for determining quality of milk and presence of mastitis
US8377398B2 (en) 2005-05-31 2013-02-19 The Board Of Regents Of The University Of Texas System Methods and compositions related to determination and use of white blood cell counts
US20060267731A1 (en) * 2005-05-31 2006-11-30 Chen Thomas C H System and apparatus of Internet-linked RFID sensor network for object identifying, sensing, monitoring, tracking and networking
US7456960B2 (en) * 2005-06-06 2008-11-25 Particle Measuring Systems, Inc. Particle counter with improved image sensor array
US20060275852A1 (en) * 2005-06-06 2006-12-07 Montagu Jean I Assays based on liquid flow over arrays
US7749531B2 (en) * 2005-06-08 2010-07-06 Indicator Systems International Apparatus and method for detecting bacterial growth beneath a wound dressing
US7681436B2 (en) * 2005-06-22 2010-03-23 Hitek Aqua Systems, Llc In-situ water analysis method and system
CA2613078A1 (en) * 2005-06-24 2007-01-04 Board Of Regents, The University Of Texas System Systems and methods including self-contained cartridges with detection systems and fluid delivery systems
US7409853B2 (en) * 2005-06-30 2008-08-12 Hitek Aqua Systems, Llc Floatable housing for in situ water monitoring system
US20090215646A1 (en) * 2005-07-01 2009-08-27 The Board Of Regents Of The University Of Texas Sy System and method of analyte detection using differential receptors
US20070010400A1 (en) * 2005-07-06 2007-01-11 Sabnis Ram W Use of color changing indicators in consumer products
US8287818B2 (en) * 2005-07-18 2012-10-16 Kantrowitz Allen B Modular hospital cart
JP4764969B2 (en) * 2005-07-25 2011-09-07 ローム株式会社 Microchip measuring device
US7791728B2 (en) * 2005-08-11 2010-09-07 Hewlett-Packard Development Company, L.P. System for optically analyzing a substance with a selected single-wavelength
WO2007022483A2 (en) * 2005-08-19 2007-02-22 Bioventures, Inc. Method and device for the collection and isolation of nucleic acid
US9011473B2 (en) 2005-09-07 2015-04-21 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9358033B2 (en) * 2005-09-07 2016-06-07 Ulthera, Inc. Fluid-jet dissection system and method for reducing the appearance of cellulite
US10548659B2 (en) 2006-01-17 2020-02-04 Ulthera, Inc. High pressure pre-burst for improved fluid delivery
US8518069B2 (en) 2005-09-07 2013-08-27 Cabochon Aesthetics, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9486274B2 (en) 2005-09-07 2016-11-08 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US7556776B2 (en) * 2005-09-08 2009-07-07 President And Fellows Of Harvard College Microfluidic manipulation of fluids and reactions
US7544330B2 (en) * 2005-09-28 2009-06-09 Idexx Laboratories, Inc. Microplate sample tracking system
US9561001B2 (en) 2005-10-06 2017-02-07 Optiscan Biomedical Corporation Fluid handling cassette system for body fluid analyzer
US20070141597A1 (en) * 2005-10-25 2007-06-21 Harmon H J Biomimetic Biodetector of Toxins, Viruses, Bacteria, and Biological Factors
WO2007064597A2 (en) * 2005-11-28 2007-06-07 Pacific Biosciences Of California, Inc. Uniform surfaces for hybrid material substrates and methods for making and using same
US20080241910A1 (en) * 2007-03-27 2008-10-02 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Devices for pathogen detection
US20080241000A1 (en) * 2007-03-27 2008-10-02 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for pathogen detection
US7885793B2 (en) 2007-05-22 2011-02-08 International Business Machines Corporation Method and system for developing a conceptual model to facilitate generating a business-aligned information technology solution
US9248317B2 (en) 2005-12-02 2016-02-02 Ulthera, Inc. Devices and methods for selectively lysing cells
US7405417B2 (en) * 2005-12-20 2008-07-29 Asml Netherlands B.V. Lithographic apparatus having a monitoring device for detecting contamination
US7649359B2 (en) * 2005-12-27 2010-01-19 The Curators Of The University Of Missouri Electrostatic thin film chemical and biological sensor
FR2895667B3 (en) * 2006-01-05 2008-04-04 Rene Vinci FERTILITY DETECTOR FOR MAMMALS
US20070158804A1 (en) * 2006-01-10 2007-07-12 Semiconductor Energy Laboratory Co., Ltd. Semiconductor device, manufacturing method of semiconductor device, and RFID tag
DE102006002093B4 (en) * 2006-01-17 2010-11-25 Airbus Deutschland Gmbh Device for detecting contour deviations of a flexible component taking into account the component weight and method
US20080175963A1 (en) * 2006-01-26 2008-07-24 Bunn-O-Matic Corporation Beverage Freshness Detecting and Indicating Systems
US7652268B2 (en) * 2006-01-31 2010-01-26 Jp Laboratories, Inc General purpose, high accuracy dosimeter reader
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US8460878B2 (en) * 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for detecting cells and cellular components in small defined volumes
US8064722B1 (en) * 2006-03-07 2011-11-22 The United States Of America As Represented By The Secretary Of The Navy Method and system for analyzing signal-vector data for pattern recognition from first order sensors
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
JP2009531704A (en) * 2006-03-28 2009-09-03 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Integrated device comprising an array of photodetectors and an array of sample sites
US20100120132A1 (en) * 2006-03-31 2010-05-13 Intel Corporation Bioassays by direct optical detection of nanoparticles
CN101416046A (en) * 2006-04-13 2009-04-22 纳幕尔杜邦公司 Hand-held gas detector and method of gas detection
US7734131B2 (en) * 2006-04-18 2010-06-08 Xerox Corporation Fabry-Perot tunable filter using a bonded pair of transparent substrates
US20080038738A1 (en) * 2006-05-10 2008-02-14 The Board Of Regents Of The University Of Texas System Detecting tumor biomarker in oral cancer
US8007999B2 (en) 2006-05-10 2011-08-30 Theranos, Inc. Real-time detection of influenza virus
US8137626B2 (en) 2006-05-19 2012-03-20 California Institute Of Technology Fluorescence detector, filter device and related methods
EP1870027A1 (en) * 2006-06-21 2007-12-26 Trace Analytics GmbH Devices and method for detecting an analyte
US7549349B2 (en) * 2006-06-22 2009-06-23 Evogen, Inc. Sample cartridge for air-sampling device
EP2041556A1 (en) * 2006-06-28 2009-04-01 RGB Technologies AB A sensor kit and a system for detecting an analyte in a test environment
JP4145938B2 (en) * 2006-06-28 2008-09-03 株式会社オンチップ・バイオテクノロジーズ Cell separation chip and cell culture method using the same
US20080004504A1 (en) * 2006-06-30 2008-01-03 Kimmo Uutela System for detecting allergic reactions resulting from a chemical substance given to a patient
US20080026373A1 (en) * 2006-07-26 2008-01-31 Rodionova Natalia A Assays Based On Light Emission From Analyte Complexes Within A Cassette
ES2688281T3 (en) 2006-07-28 2018-10-31 Diagnostics For The Real World, Ltd Device, system and method to process a sample
WO2008019086A2 (en) * 2006-08-04 2008-02-14 Massachusetts Institute Of Technology Detection of explosives, toxins and other compositions
WO2008033575A2 (en) 2006-09-15 2008-03-20 Metabolon, Inc. Methods of identifying biochemical pathways
US8187541B2 (en) * 2006-09-18 2012-05-29 California Institute Of Technology Apparatus for detecting target molecules and related methods
EP2067104A1 (en) * 2006-09-28 2009-06-10 Xeround Systems Ltd. Apparatus and method for a distributed storage global database
US8283423B2 (en) 2006-09-29 2012-10-09 Massachusetts Institute Of Technology Polymer synthetic technique
US8802447B2 (en) * 2006-10-05 2014-08-12 Massachusetts Institute Of Technology Emissive compositions with internal standard and related techniques
US20080161204A1 (en) * 2006-10-06 2008-07-03 Mo-Huang Li Microwell array for parallel synthesis of chain molecules
US20080084559A1 (en) * 2006-10-10 2008-04-10 C Technologies, Inc. Microvolume sampling device
US20090215189A1 (en) 2006-10-27 2009-08-27 Massachusetts Institute Of Technology Sensor of species including toxins and chemical warfare agents
US20080113391A1 (en) 2006-11-14 2008-05-15 Ian Gibbons Detection and quantification of analytes in bodily fluids
WO2008140490A2 (en) * 2006-11-21 2008-11-20 Cornell Research Foundation, Inc. Flexible substrate sensor system for environmental and infrastructure monitoring
US7522282B2 (en) 2006-11-30 2009-04-21 Purdue Research Foundation Molecular interferometric imaging process and apparatus
US9273345B2 (en) * 2006-12-28 2016-03-01 Conceptual Mindworks, Inc. Methods and compositions for processes of rapid selection and production of nucleic acid aptamers
US8323982B2 (en) * 2007-01-11 2012-12-04 Valencell, Inc. Photoelectrocatalytic fluid analyte sensors and methods of fabricating and using same
WO2008089282A2 (en) * 2007-01-16 2008-07-24 Silver James H Sensors for detecting subtances indicative of stroke, ischemia, infection or inflammation
US9945789B2 (en) 2007-01-16 2018-04-17 Alverix, Inc. Multiple analyte detection systems and methods of detecting multiple analytes
US7659968B2 (en) * 2007-01-19 2010-02-09 Purdue Research Foundation System with extended range of molecular sensing through integrated multi-modal data acquisition
HUE044597T2 (en) 2007-01-21 2019-11-28 Gt Acquisition Sub Inc Animal management system and corresponding method including radio animal tag and additional transceiver(s)
US20080180259A1 (en) * 2007-01-29 2008-07-31 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Devices for allergen detection
US20080181816A1 (en) * 2007-01-29 2008-07-31 Searete Llc, A Limited Liability Corporation Systems for allergen detection
US8617903B2 (en) * 2007-01-29 2013-12-31 The Invention Science Fund I, Llc Methods for allergen detection
US20080181821A1 (en) * 2007-01-29 2008-07-31 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Microfluidic chips for allergen detection
US10001496B2 (en) * 2007-01-29 2018-06-19 Gearbox, Llc Systems for allergen detection
US8168140B2 (en) * 2007-01-31 2012-05-01 Agilent Technologies, Inc. Microfluidic apparatuses with nanochannels
WO2008118934A1 (en) 2007-03-26 2008-10-02 Purdue Research Foundation Method and apparatus for conjugate quadrature interferometric detection of an immunoassay
US20090227005A1 (en) * 2007-03-27 2009-09-10 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods for pathogen detection
US20080243865A1 (en) * 2007-03-28 2008-10-02 Oracle International Corporation Maintaining global state of distributed transaction managed by an external transaction manager for clustered database systems
US20080300798A1 (en) * 2007-04-16 2008-12-04 Mcdevitt John T Cardibioindex/cardibioscore and utility of salivary proteome in cardiovascular diagnostics
EP2139602A1 (en) * 2007-04-25 2010-01-06 3M Innovative Properties Company Chemical component and processing device assembly
WO2008134462A1 (en) * 2007-04-25 2008-11-06 3M Innovative Properties Company Supported reagents, methods, and devices
US8597190B2 (en) 2007-05-18 2013-12-03 Optiscan Biomedical Corporation Monitoring systems and methods with fast initialization
KR100903969B1 (en) * 2007-06-12 2009-06-25 삼성전자주식회사 Microarray, substrate for microarray and methods of fabricating the same
US20090014340A1 (en) * 2007-06-15 2009-01-15 Williams John R Devices, systems, and methods for measuring glucose
US9458451B2 (en) 2007-06-21 2016-10-04 Gen-Probe Incorporated Multi-channel optical measurement instrument
US8921121B2 (en) * 2007-06-29 2014-12-30 The Trustees Of Columbia University In The City Of New York Methods, devices, and systems for chemiluminescence-based microfluidic cell counting
US8431090B2 (en) * 2007-06-29 2013-04-30 The Trustees Of Columbia University In The City Of New York Microfluidic device for counting biological particles
US8790877B2 (en) * 2007-07-12 2014-07-29 The United States Of America As Represented By The Secretary Of The Air Force Using DNA aptamers and quantum dots for the detection of proteins or other targets
US8158430B1 (en) 2007-08-06 2012-04-17 Theranos, Inc. Systems and methods of fluidic sample processing
US9707556B2 (en) 2007-08-17 2017-07-18 Diagnostics For The Real World, Ltd. Device, system and method for processing a sample
CA2734029C (en) 2007-08-30 2016-03-29 The Trustees Of Tufts College Methods for determining the concentration of an analyte in solution
US8318107B2 (en) * 2007-09-05 2012-11-27 Biosense Technologies, Inc. Apparatus and method for specimen suitability testing
EP2237687B1 (en) * 2007-09-06 2016-08-03 Fredrica V. Coates Infant wrap including body padding
CN101836107B (en) * 2007-09-10 2013-04-10 香港大学 Electronic tongue sensor
GB0719373D0 (en) * 2007-10-04 2007-11-14 Univ Cranfield Optical multisensor
US20090093738A1 (en) * 2007-10-09 2009-04-09 Cabochon Aesthetics, Inc. Device and method for monitoring a treatment area
US8439940B2 (en) 2010-12-22 2013-05-14 Cabochon Aesthetics, Inc. Dissection handpiece with aspiration means for reducing the appearance of cellulite
US7978079B2 (en) * 2007-10-12 2011-07-12 Destron Fearing Corporation Electronic tag
US20090148342A1 (en) * 2007-10-29 2009-06-11 Bromberg Steven E Hypochlorite Technology
EP2215211A1 (en) * 2007-11-06 2010-08-11 3M Innovative Properties Company Processing device tablet
US8637271B2 (en) * 2007-11-08 2014-01-28 Indicator Systems International, Inc. Polymeric indicators for detecting the presence of metabolic byproducts from microorganisms
CN101918829A (en) * 2007-11-20 2010-12-15 3M创新有限公司 Pick-up unit and method
US20140236351A1 (en) * 2007-11-29 2014-08-21 Searete Llc Programmed Dispensing of Consumable Compositions
EP2232231A4 (en) 2007-12-04 2015-12-02 Particle Measuring Syst Non-orthogonal particle detection systems and methods
US7897410B2 (en) * 2007-12-18 2011-03-01 Texas Instruments Incorporated Close proximity scanning surface contamination analyzer
US9480982B2 (en) 2007-12-24 2016-11-01 Honeywell International Inc. Reactor for the quantitative analysis of nucleic acids
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
US20110039033A1 (en) * 2008-01-31 2011-02-17 Erika Merschrod Method of depositing a polymer micropattern on a substrate
JP5283924B2 (en) * 2008-02-21 2013-09-04 株式会社日立製作所 Nucleic acid amplification device
US20090270269A1 (en) * 2008-04-28 2009-10-29 Ashok Kumar Nano-scale fluoro-biosensors exhibiting a low false alarm rate for rapid detection of biological contaminants
WO2009134395A2 (en) 2008-04-28 2009-11-05 President And Fellows Of Harvard College Microfluidic device for storage and well-defined arrangement of droplets
US9394184B1 (en) 2008-04-30 2016-07-19 Hitek Aqua Systems System for and method of regulating calcium hardness for a body of water
US8148161B2 (en) * 2008-05-02 2012-04-03 The United States Of America, As Represented By The Secretary Of The Navy Selective membranes/thin films for analytical applications
US8181531B2 (en) * 2008-06-27 2012-05-22 Edwin Carlen Accessible stress-based electrostatic monitoring of chemical reactions and binding
US9011670B2 (en) * 2008-08-14 2015-04-21 The Charles Stark Draper Laboratory, Inc. Three-dimensional metal ion sensor arrays on printed circuit boards
WO2010022330A2 (en) * 2008-08-21 2010-02-25 University Of Florida Research Foundation, Inc. Differential laser-induced perturbation (dlip) for bioimaging and chemical sensing
WO2010028057A1 (en) * 2008-09-04 2010-03-11 The Board Of Trustees Of The University Of Illinois Colorimetric sensor arrays based on nanoporous pigments
US20100058834A1 (en) * 2008-09-09 2010-03-11 Honeywell International Inc. Method and apparatus for low drift chemical sensor array
EP2334792B1 (en) 2008-09-12 2020-09-09 GenTegra LLC Matrices and media for storage and stabilization of biomolecules
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
AU2009293019A1 (en) 2008-09-19 2010-03-25 Tandem Diabetes Care Inc. Solute concentration measurement device and related methods
US20100075439A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation Ultra-sensitive detection of molecules by capture-and-release using reducing agents followed by quantification
US20100075862A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation High sensitivity determination of the concentration of analyte molecules or particles in a fluid sample
US8222047B2 (en) 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
EP2362947B1 (en) 2008-09-30 2017-05-10 Pacific Biosciences of California, Inc. Ultra-high multiplex analytical systems and methods
US7923715B2 (en) * 2008-12-06 2011-04-12 The United States Of America As Represented By The Administrator Of National Aeronautics And Space Administration Chalcogenide nanoionic-based radio frequency switch
US20100147832A1 (en) * 2008-12-16 2010-06-17 Barker Iii Charles R Induction cookware identifying
US20100179074A1 (en) * 2009-01-15 2010-07-15 Honeywell International Inc. Methods and apparatus for fluid delivery and removal of micron scale structures
WO2010085755A1 (en) * 2009-01-26 2010-07-29 Indicator Systems International, Inc. Indicators for detecting the presence of metabolic byproducts from microorganisms
WO2010090810A2 (en) * 2009-02-05 2010-08-12 Hydradx, Inc. Diagnostic device and method
EP2221606A3 (en) * 2009-02-11 2012-06-06 Samsung Electronics Co., Ltd. Integrated bio-chip and method of fabricating the integrated bio-chip
JP4849278B2 (en) * 2009-03-27 2012-01-11 セイコーエプソン株式会社 Cell treatment device, cell treatment cartridge, and body fluid treatment system
FI20095501A0 (en) 2009-05-04 2009-05-04 Pekka Haenninen Procedure for characterization and / or determination of samples
WO2010148252A1 (en) * 2009-06-17 2010-12-23 Jody Vykoukal Method and apparatus for quantitative microimaging
AU2010266335A1 (en) * 2009-07-01 2012-02-02 Board Of Regents, The University Of Texas System Methods of determining the presence and/or concentration of an analyte in a sample
EP2456355B1 (en) 2009-07-20 2016-09-14 Optiscan Biomedical Corporation Adjustable connector and dead space reduction
US9554742B2 (en) 2009-07-20 2017-01-31 Optiscan Biomedical Corporation Fluid analysis system
GB0913258D0 (en) * 2009-07-29 2009-09-02 Dynex Technologies Inc Reagent dispenser
US9523701B2 (en) 2009-07-29 2016-12-20 Dynex Technologies, Inc. Sample plate systems and methods
AU2010278894B2 (en) 2009-07-30 2014-01-30 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US9358064B2 (en) 2009-08-07 2016-06-07 Ulthera, Inc. Handpiece and methods for performing subcutaneous surgery
US11096708B2 (en) 2009-08-07 2021-08-24 Ulthera, Inc. Devices and methods for performing subcutaneous surgery
US8248255B2 (en) * 2009-10-13 2012-08-21 Verifuel Ltd. Optical fluid tester
US8862448B2 (en) 2009-10-19 2014-10-14 Theranos, Inc. Integrated health data capture and analysis system
EP2494353B1 (en) * 2009-10-30 2017-09-27 Illumina Inc. An apparatus comprising a plurality of encoded microvessels and a plurality of compartments and a method of reading a plurality of encoded micro vessels
US9700889B2 (en) 2009-11-23 2017-07-11 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
US9759718B2 (en) 2009-11-23 2017-09-12 Cyvek, Inc. PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use
US10022696B2 (en) 2009-11-23 2018-07-17 Cyvek, Inc. Microfluidic assay systems employing micro-particles and methods of manufacture
US9500645B2 (en) 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
US10065403B2 (en) 2009-11-23 2018-09-04 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
US9855735B2 (en) 2009-11-23 2018-01-02 Cyvek, Inc. Portable microfluidic assay devices and methods of manufacture and use
WO2011063408A1 (en) 2009-11-23 2011-05-26 Cyvek, Inc. Method and apparatus for performing assays
WO2011112222A2 (en) 2009-12-15 2011-09-15 Nomadics, Inc. Multi-analyte detection system and method
JP5663985B2 (en) * 2009-12-16 2015-02-04 ソニー株式会社 Cell for microbead inspection and method for analyzing microbead
US8702941B2 (en) * 2009-12-25 2014-04-22 ARKARY, Inc. Method of analyzing hemoglobin by electrophoresis
US8640525B2 (en) * 2009-12-30 2014-02-04 Monsanto Technology Llc Methods and systems for differentiating soybeans
CN102791882A (en) 2010-01-20 2012-11-21 霍尼韦尔国际公司 Reactor for quantitative analysis of nucleic acids
US8338182B2 (en) * 2010-02-08 2012-12-25 Arizona Board of Regents, a body corporate acting for and on behalf of Arizona State University Methods and systems for fluid examination and remediation
US8415171B2 (en) * 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US9678068B2 (en) * 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
US9110025B2 (en) 2010-03-01 2015-08-18 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
RU2615367C2 (en) * 2010-03-31 2017-04-04 Хилин Лайф Продактс Инк. Device for predicting of ovulation
US8363224B2 (en) 2010-03-31 2013-01-29 General Electric Company Fringe locking subsystem and methods of making and using the same
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
EP2571529A2 (en) 2010-05-14 2013-03-27 Mallinckrodt LLC Functional, cross-linked nanostructures for tandem optical imaging and therapy
EP2580589B1 (en) 2010-06-09 2016-08-31 Optiscan Biomedical Corporation Measuring analytes in a fluid sample drawn from a patient
EP2397859B1 (en) 2010-06-15 2020-02-05 F. Hoffmann-La Roche AG Optical surveillance of mixing and separation
US20110312727A1 (en) 2010-06-17 2011-12-22 Geneasys Pty Ltd Loc device with parallel nucleic acid amplification functionality
WO2012050646A2 (en) 2010-06-29 2012-04-19 The Trustees Of The University Of Pennsylvania Biomimetic chemical sensors using nanoelectronic readout of olfactory receptors
WO2012013959A1 (en) * 2010-07-29 2012-02-02 Dynex Technologies, Inc. Sample plate
WO2012065117A2 (en) 2010-11-12 2012-05-18 William Marsh Rice University Oral cancer point of care diagnostics
WO2012065025A2 (en) 2010-11-12 2012-05-18 William Marsh Rice University Prostate cancer point of care diagnostics
KR101037099B1 (en) 2010-11-30 2011-05-25 주식회사 이바이오젠 Vibrated hybridization biochip system using bead chamber
US8586913B2 (en) 2011-01-10 2013-11-19 Schlumberger Technology Corporation Fluidic density measurements based on beta particles detection
EP2481703B1 (en) * 2011-01-27 2020-07-01 Sensirion AG Sensor protection
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
CN103649759B (en) 2011-03-22 2016-08-31 西维克公司 Microfluidic device and manufacture method and purposes
US9252175B2 (en) 2011-03-23 2016-02-02 Nanohmics, Inc. Method for assembly of spectroscopic filter arrays using biomolecules
US9828696B2 (en) 2011-03-23 2017-11-28 Nanohmics, Inc. Method for assembly of analyte filter arrays using biomolecules
US20140302532A1 (en) 2011-04-12 2014-10-09 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
WO2012155097A2 (en) * 2011-05-11 2012-11-15 Luminex Corporation Systems and methods for producing an evaporation barrier in a reaction chamber
CA2836061A1 (en) 2011-05-12 2012-11-15 William Marsh Rice University Bio-nano-chips for on-site drug screening
DE102011050389B4 (en) * 2011-05-16 2021-09-02 Presens - Precision Sensing Gmbh Sensor unit and measurement method
US8660968B2 (en) 2011-05-25 2014-02-25 Azure Vault Ltd. Remote chemical assay classification
JP5765081B2 (en) * 2011-06-22 2015-08-19 ソニー株式会社 Image sensor, electronic device, manufacturing method, and inspection apparatus
ITTO20110567A1 (en) * 2011-06-28 2012-12-29 St Microelectronics Srl CARTRIDGE FOR BIOCHEMICAL ANALYSIS, BIOCHEMICAL ANALYSIS SYSTEM AND METHOD TO PERFORM A BIOCHEMICAL PROCESS
WO2013006716A1 (en) 2011-07-06 2013-01-10 Optiscan Biomedical Corporation Sample cell for fluid analysis system
WO2013019852A2 (en) 2011-08-01 2013-02-07 Tandem Diabetes Care, Inc. Therapy management system
KR101312272B1 (en) * 2011-08-09 2013-09-25 삼성에스디아이 주식회사 Photoelectric conversion device
WO2013033359A1 (en) 2011-08-31 2013-03-07 The Trustees Of The University Of Pennsylvania Carbon nanotube biosensors and related methods
US20130078615A1 (en) * 2011-09-26 2013-03-28 Alberto Gandini Device and Method for Detection and Quantification of Immunological Proteins, Pathogenic and Microbial Agents and Cells
US20130092846A1 (en) * 2011-10-18 2013-04-18 Uwm Research Foundation, Inc. Fiber-optic sensors for real-time monitoring
KR101876540B1 (en) 2011-12-28 2018-07-10 삼성디스플레이 주식회사 Flexible display apparatus and the method of manufacturing the same
US9075021B2 (en) 2012-02-17 2015-07-07 Toyota Motor Engineering & Manufacturing North America, Inc. Methods and systems for monitoring content of coating solutions using automated titration devices
EP2822689B1 (en) 2012-03-08 2023-07-26 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
US8850689B2 (en) * 2012-03-23 2014-10-07 Delta Electronics, Inc. Method for manufacturing switchable particle-based display using a pre-filling process
US10132802B2 (en) 2012-04-17 2018-11-20 i-calQ, LLC Device for performing a diagnostic test and methods for use thereof
CA2870635C (en) * 2012-04-17 2019-04-09 Joel R. L. Ehrenkranz Device for performing a diagnostic test and methods for use thereof
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
GB2502306A (en) * 2012-05-22 2013-11-27 Univ Singapore Microparticle sensor
EP3725409A1 (en) * 2012-06-01 2020-10-21 Vycap B.V. A microsieve diagnostic device in the isolation and analysis of single cells
US9555186B2 (en) 2012-06-05 2017-01-31 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
WO2014034781A1 (en) * 2012-08-31 2014-03-06 国立大学法人東京大学 Detector and detection method
US9310357B2 (en) 2012-09-28 2016-04-12 Src, Inc. Detection of chemical and biological agents using oligonucleotide aptamers
US9932626B2 (en) 2013-01-15 2018-04-03 Quanterix Corporation Detection of DNA or RNA using single molecule arrays and other techniques
WO2014116179A1 (en) * 2013-01-22 2014-07-31 Nitto Denko Corporation A hydrogel, for use in a biosensor with optics based detection of analytes
EP2763065A1 (en) * 2013-01-31 2014-08-06 Sensirion AG Method and system for identifying a fluid sample
WO2014121802A1 (en) * 2013-02-07 2014-08-14 Zaghloul Mohammad Hosam Eldeen Innovative nano-elisa single test for the detection of hcv, hiv antibodies and hbsag
US8995658B2 (en) 2013-02-13 2015-03-31 Honeywell International Inc. Physics-based key generation
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
US9492608B2 (en) 2013-03-15 2016-11-15 Tandem Diabetes Care, Inc. Method and device utilizing insulin delivery protocols
US9097712B2 (en) 2013-03-15 2015-08-04 Allied Innovative Systems Llc Flow-through cell counting assay
US9248448B2 (en) 2013-04-24 2016-02-02 William Marsh Rice University Multisample bionanochip platform
ITVR20130132A1 (en) * 2013-05-29 2014-11-30 Optoelettronica Italia S R L KIT FOR DETECTION OF MICRO-RNA EXTRACTED FROM A SAMPLE OF BODY FLUID AS WELL AS METHOD OF DETECTION OF THE SAME
GB2515490A (en) * 2013-06-24 2014-12-31 Univ Dublin City An aperture array substrate device, a detection system and a method for detecting analytes in a sample
EP3013983B1 (en) 2013-06-25 2023-02-15 Prognosys Biosciences, Inc. Spatially encoded biological assays using a microfluidic device
GB201315327D0 (en) * 2013-08-28 2013-10-09 Anmat Technology Ltd Apparatus for detecting an analyte using a fluid having magnetic particles with a binding ligand for binding the analyte
CN103487880B (en) * 2013-09-30 2016-05-25 南京华信藤仓光通信有限公司 The device that optical fiber in fibre bundle or the easy stripping means of optical fiber ribbon and silicone oil are applied
US9465960B2 (en) 2013-12-04 2016-10-11 Honeywell International Inc. Physics-based authentication
US10109612B2 (en) * 2013-12-13 2018-10-23 Taiwan Semiconductor Manufacturing Company Tools and systems for processing semiconductor devices, and methods of processing semiconductor devices
WO2015095239A1 (en) 2013-12-18 2015-06-25 Optiscan Biomedical Corporation Systems and methods for detecting leaks
TW201527756A (en) * 2014-01-10 2015-07-16 Nat Univ Tsing Hua Method, computer program product, system for providing food safety map
EP3101410A4 (en) * 2014-01-28 2017-08-30 Osaka University Observation apparatus, device, device production method, particle diameter measurement method, resistance property observation method, chemical reaction method, particle preservation method, and automated observation apparatus
WO2015121533A1 (en) 2014-02-11 2015-08-20 Wallac Oy A device and a method for managing a sample to be analyzed and a solid sample carrier and liquid sample carrier
DE102014203266B4 (en) * 2014-02-24 2018-07-19 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Composition with FRET pair in defined geometry
JP6480210B2 (en) * 2014-02-28 2019-03-06 アークレイ株式会社 Plasma generating chip, plasma generating apparatus, and plasma spectroscopic analysis method
GB2524541A (en) * 2014-03-26 2015-09-30 Ibm Microfluidic chip with conic bead trapping cavities and fabrication thereof
DE102014104595A1 (en) * 2014-04-01 2015-10-01 Michael Himmelhaus Method and device for label-free detection of an analyte
US9466459B2 (en) * 2014-06-03 2016-10-11 Protochips, Inc. Method for optimizing fluid flow across a sample within an electron microscope sample holder
US10031104B2 (en) * 2014-06-13 2018-07-24 Yes Way Intellectual Holdings, Llc Mobile micro-lab for chemical analysis of fluids
US10309976B2 (en) 2014-06-30 2019-06-04 Phc Holdings Corporation Substrate for sample analysis, sample analysis device, sample analysis system, and program for sample analysis system
JP6548645B2 (en) 2014-06-30 2019-07-24 Phcホールディングス株式会社 Substrate for sample analysis and sample analyzer
WO2016002729A1 (en) 2014-06-30 2016-01-07 パナソニックヘルスケアホールディングス株式会社 Substrate for sample analysis, sample analysis device, sample analysis system, and program for sample analysis system
EP3163307B1 (en) 2014-06-30 2021-03-03 PHC Holdings Corporation Substrate for sample analysis, sample analysis device, sample analysis system, and method for removing liquid from liquid that contains magnetic particles
US10416144B2 (en) 2014-07-28 2019-09-17 Kansas State University Research Foundation Nanosensors for detecting enzymatic activity in dairy production
EP3180613B1 (en) * 2014-08-11 2023-10-18 The Regents of The University of California Continuous analyte sensor
US11415546B2 (en) 2014-09-05 2022-08-16 The Trustees Of The University Of Pennsylvania Volatile organic compound-based diagnostic systems and methods
EP3201841A1 (en) 2014-09-29 2017-08-09 Avery Dennison Corporation Tire tracking rfid label
CN104406916A (en) * 2014-11-04 2015-03-11 百度在线网络技术(北京)有限公司 Method and apparatus for detecting food
CN107209193B (en) 2014-12-12 2019-08-02 普和希控股公司 Sample analysis substrate, sample analyzer, sample analysis system and sample analysis system program
AU2016200047A1 (en) * 2015-01-07 2016-07-21 Personal Genomics, Inc. Oriented Loading Systems And Method For Orienting A Particle Loaded In A Well
DE102015001998B3 (en) * 2015-02-20 2016-02-04 Friz Biochem Gesellschaft Für Bioanalytik Mbh Microfluidic cartridge for the detection of biomolecules
WO2016145300A1 (en) * 2015-03-11 2016-09-15 Nano Engineered Applications, Inc. Chemical sensor
FI3901281T3 (en) 2015-04-10 2023-01-31 Spatially distinguished, multiplex nucleic acid analysis of biological specimens
US9867250B1 (en) 2015-04-20 2018-01-09 The Arizona Board Of Regents On Behalf Of The University Of Arizona System having a configurable pico-second pulsed LED driver circuit and photomultiplier tube biasing and gating circuits for real-time, time-resolved transient recording of fluorescence
WO2016193181A1 (en) * 2015-05-29 2016-12-08 Nanoimmunotech, S.L. Biosensors, kits and assays for measuring metalloproteinase and serine protease activities
US10716500B2 (en) 2015-06-29 2020-07-21 Cardiac Pacemakers, Inc. Systems and methods for normalization of chemical sensor data based on fluid state changes
US10399130B2 (en) 2015-07-22 2019-09-03 Arizona Board Of Regents On Behalf Of Arizona State University Methods and systems for in situ temporary containment of shallow contaminated soils
US11521475B1 (en) 2015-08-31 2022-12-06 Hitek Aqua Systems System for and method remotely monitoring chemistry of recreational water facilities
WO2017058806A1 (en) * 2015-09-28 2017-04-06 The Regents Of The University Of California Wearable sensor arrays for in-situ body fluid analysis
US10228367B2 (en) 2015-12-01 2019-03-12 ProteinSimple Segmented multi-use automated assay cartridge
US10386351B2 (en) 2015-12-07 2019-08-20 Nanohmics, Inc. Methods for detecting and quantifying analytes using gas species diffusion
US10386365B2 (en) 2015-12-07 2019-08-20 Nanohmics, Inc. Methods for detecting and quantifying analytes using ionic species diffusion
US10849600B2 (en) 2016-03-08 2020-12-01 Entech Instruments Inc. Breath condensate and saliva analysis using oral rinse
AU2017232651A1 (en) 2016-03-18 2018-10-04 ConnectedYard, Inc. Chemical monitoring devices and methods
US10190973B2 (en) * 2016-03-31 2019-01-29 Sensor Electronic Technology, Inc. Integrated ultraviolet analyzer
US10926025B2 (en) 2016-09-15 2021-02-23 Tandem Diabetes Care, Inc. Vial supporter for medicament pump
WO2018057883A1 (en) * 2016-09-22 2018-03-29 Src, Inc. Methods and systems for detection and tracking of mastitis in dairy cattle
WO2018132578A1 (en) 2017-01-11 2018-07-19 Tandem Diabetes Care, Inc. Electromagnetic signal-based infusion pump control
RU175245U1 (en) * 2017-01-13 2017-11-28 Сергей Викторович Минаев Separation device for determining biochemical parameters and markers of diseases in blood plasma
US10895527B2 (en) * 2017-01-31 2021-01-19 Bahcesehir Universitesi Illumination assembly for underwater illumination
US20180246071A1 (en) * 2017-02-28 2018-08-30 Entech Instruments Inc. Increasing the Sensitivity of Gas Chromatography and Gas Chromatography-Mass Spectrometry Analysis By Allowing Relatively Large Solvent Volume Injections While Reducing Sample Loss And System Contamination
US10641733B2 (en) * 2017-03-20 2020-05-05 National Technology & Engineering Solutions Of Sandia, Llc Active mechanical-environmental-thermal MEMS device for nanoscale characterization
US10934184B2 (en) 2017-03-21 2021-03-02 Hayward Industries, Inc. Systems and methods for sanitizing pool and spa water
US10429303B2 (en) * 2017-03-24 2019-10-01 International Business Machines Corporation Portable and autonomous, IoT enabled, optical measurement system
US10684277B2 (en) * 2017-07-24 2020-06-16 Comsats Institute Of Information Technology Colorimetric filter paper assay for rapid monitoring of cholesterol level
CN107621455A (en) * 2017-08-02 2018-01-23 广西中医药大学制药厂 The assay method of total cardiac glycoside content in strong medicinal material rattan kuh-seng
EP3669178B1 (en) 2017-08-17 2023-07-19 Abbott Point Of Care Inc Systems for performing optical and electrochemical assays
US20190054466A1 (en) * 2017-08-17 2019-02-21 Abbott Point Of Care Inc. Single-use test device for imaging blood cells
CN111183349A (en) * 2017-08-17 2020-05-19 雅培医护站股份有限公司 Single use test device for imaging assay beads
US20190056385A1 (en) * 2017-08-17 2019-02-21 Abbott Point Of Care Inc. Method of imaging assay beads in a biological sample
CN111164412A (en) * 2017-08-17 2020-05-15 雅培医护站股份有限公司 Method of imaging blood cells
EP3460472A1 (en) 2017-09-22 2019-03-27 Nokia Technologies Oy Functionalised particles
CA3079837A1 (en) * 2017-11-01 2019-05-09 The Board Of Trustees Of The Leland Stanford Junior University Analyte detection method
WO2019118445A1 (en) * 2017-12-12 2019-06-20 Trustees Of Boston University Disposable fluidic cartridge for interferometric reflectance imaging sensor
ES2956109T3 (en) * 2018-02-15 2023-12-13 Procisedx Inc Analyzer
EP3742969A1 (en) 2018-03-06 2020-12-02 Entech Instruments Inc. Ventilator-coupled sampling device and method
US11459604B2 (en) 2018-07-12 2022-10-04 Luminex Corporation Systems and methods for performing variable sample preparation and analysis processes
CN108956760A (en) * 2018-08-01 2018-12-07 京东方科技集团股份有限公司 Detection device and detection system
US11592427B2 (en) 2018-10-01 2023-02-28 Brown University Multi-parametric machine olfaction
CN113302492A (en) * 2019-01-03 2021-08-24 彼克斯赛尔医疗科技有限公司 System and method for analyzing a fluid sample
EP3927391A4 (en) 2019-02-19 2022-11-16 Tandem Diabetes Care, Inc. System and method of pairing an infusion pump with a remote control device
US11754545B2 (en) * 2019-02-26 2023-09-12 Pentair Water Pool & Spa, Inc. Water quality monitor system and method
WO2020180327A1 (en) * 2019-03-07 2020-09-10 Hewlett-Packard Development Company, L.P. Nucleic acid detection
DE102019106194B4 (en) * 2019-03-12 2020-12-03 Surflay Nanotec Gmbh Device for the spectroscopic determination of the binding kinetics of an analyte
EP3946514A4 (en) 2019-03-26 2022-12-21 Tandem Diabetes Care, Inc. Method of pairing an infusion pump with a remote control device
WO2020205418A1 (en) * 2019-03-29 2020-10-08 Polymer Technology Systems, Inc. Systems and methods for test strip insertion positioning check and type match
WO2020210981A1 (en) * 2019-04-16 2020-10-22 Boe Technology Group Co., Ltd. Micro-channel device and manufacturing method thereof and micro-fluidic system
WO2020247662A1 (en) * 2019-06-04 2020-12-10 The Regents Of The University Of California Diboronic acid compounds and methods of making and using thereof
US20220276235A1 (en) * 2019-07-18 2022-09-01 Essenlix Corporation Imaging based homogeneous assay
RU2722604C1 (en) * 2019-08-01 2020-06-02 федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный университет" (ФГБОУ ВО "ВГУ") Device for spectral analysis
US11327084B2 (en) * 2019-09-19 2022-05-10 Invidx Corp. Joint hematology and biochemistry point-of-care testing system
CA3161529A1 (en) 2019-12-10 2021-06-17 Robert TOKER Probes for chemical analysis and related methods
JP2023510105A (en) * 2019-12-17 2023-03-13 ランサ・インコーポレーテッド Mobile device for chemical analysis and related methods
CN111229337B (en) * 2020-01-17 2021-11-30 上海新微技术研发中心有限公司 Method for manufacturing optical waveguide multi-micro-channel chip
EP4153775A1 (en) 2020-05-22 2023-03-29 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
CN111924541B (en) * 2020-07-01 2021-12-07 山东聊城华阳医药辅料有限公司 Pneumatic pipeline conveying device based on photosensitive resistance value characteristics
WO2022093212A1 (en) * 2020-10-28 2022-05-05 Hewlett-Packard Development Company, L.P. Self-wicking assay devices
KR20220119357A (en) * 2021-02-19 2022-08-29 주식회사 히타치하이테크 plasma processing unit
US20220365015A1 (en) * 2021-05-17 2022-11-17 Rhythmic Health, Inc. Mip sensor device with replaceable mip sensor
WO2022251538A1 (en) * 2021-05-27 2022-12-01 Siren Care, Inc. Sensor arrangements for a sensing garment
CN113358619B (en) * 2021-06-05 2023-05-19 中国科学院新疆理化技术研究所 Preparation method and application of fluorescence sensing analysis card for semi-quantitatively detecting potassium permanganate solution
CN113252862B (en) * 2021-07-14 2021-09-17 四川久环环境技术有限责任公司 Water quality monitoring station
CN114015560A (en) * 2021-10-20 2022-02-08 深圳市中科先见医疗科技有限公司 Molecular detection chip

Family Cites Families (214)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1543970B2 (en) * 1965-11-29 1977-04-21 Witco Chemical Corp., New York, N. Y. (V.StA.) PROCESS FOR PRODUCTION OF STABLE, LIQUID, POLYFUNCTIONAL DETERGENT BLENDS
US3587040A (en) 1968-08-12 1971-06-22 Qonaar Corp Vehicle detector
US3696932A (en) 1970-09-30 1972-10-10 Pall Corp Disposable filter assembly
US3701433A (en) 1970-11-10 1972-10-31 Pall Corp Filter for use in the filtration of blood
US3709868A (en) 1971-03-08 1973-01-09 Hoffmann La Roche Opium alkaloid antigens and antibodies specific therefor
US3843696A (en) * 1972-09-05 1974-10-22 Syva Co Methadone analog compounds
US3775742A (en) 1972-09-18 1973-11-27 Canoga Controls Corp Vehicle detection system
CS164231B2 (en) 1972-09-28 1975-11-07
US3856469A (en) 1973-01-02 1974-12-24 Syva Corp Interferant removal from amphetamine immunoassay
US3954623A (en) 1974-05-28 1976-05-04 Johnson & Johnson Blood filtration unit
US3876504A (en) 1974-06-10 1975-04-08 Early Warning Co Procedure for determination of antigens and antibodies and articles for use therewith
US4189382A (en) 1974-11-07 1980-02-19 Sherwood Medical Industries Inc. Blood coagulation and separation
US4036946A (en) * 1975-10-20 1977-07-19 Marcos Kleinerman Immunofluorometric method for measuring minute quantities of antigens, antibodies and other substances
US4050898A (en) 1976-04-26 1977-09-27 Eastman Kodak Company Integral analytical element
US4069017A (en) 1977-01-14 1978-01-17 Eastman Kodak Company Colorimetric assay for bilirubin
US4200613A (en) 1977-06-03 1980-04-29 Ramco Laboratories Inc. Radioimmunoassay apparatus
US4115277A (en) 1977-06-17 1978-09-19 Pioneer Filters, Inc. Blood filtering apparatus of graduated fiber density
US4294817A (en) * 1977-11-25 1981-10-13 International Diagnostic Technology, Inc. Method of fluoro immunoassay
US4245041A (en) * 1977-12-07 1981-01-13 American Monitor Corporation Triglycerides assay and reagents therefor
US4246107A (en) * 1978-03-06 1981-01-20 Asahi Kasei Kogyo Kabushiki Kaisha Separation of lymphocytes from lymphocyte-containing suspension by filtration
US4378429A (en) 1979-08-23 1983-03-29 Modrovich Ivan Endre Enzymatic method and stabilized solutions for determining total cholesterol in human serum
JPS5659802A (en) * 1979-10-23 1981-05-23 Shinroihi Kk Microspherical polymer particle and production thereof
US4344743A (en) 1979-12-04 1982-08-17 Bessman Samuel P Piezoelectric driven diaphragm micro-pump
DE3029579C2 (en) * 1980-08-05 1985-12-12 Boehringer Mannheim Gmbh, 6800 Mannheim Method and means for separating plasma or serum from whole blood
US4596657A (en) 1982-06-04 1986-06-24 Miles Laboratories, Inc. Blood bag system with integral filtering means
US4588665A (en) * 1982-11-22 1986-05-13 Drexler Technology Corporation Micrographic film member with laser written data
US4567149A (en) 1983-03-17 1986-01-28 Mast Immunosystems, Ltd. Binding assay system and method of making and using same
US4493815A (en) * 1983-07-28 1985-01-15 Bio-Rad Laboratories, Inc. Supporting and filtering biochemical test plate assembly
US4672028A (en) * 1984-05-23 1987-06-09 Icn Micromedic Systems, Inc. Compositions and method for simultaneous multiple array of analytes using radioisotope chelate labels
US4681742A (en) * 1984-10-01 1987-07-21 Cetus Corporation Assay tray
JPH0823558B2 (en) * 1984-11-27 1996-03-06 オ−ジエニクス リミテツド Verification device
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) * 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US5354825A (en) 1985-04-08 1994-10-11 Klainer Stanley M Surface-bound fluorescent polymers and related methods of synthesis and use
US4661445A (en) 1985-05-24 1987-04-28 Saxinger W Carl Competitive ELISA for the detection of HTLV-III antibodies
US4623461A (en) 1985-05-31 1986-11-18 Murex Corporation Transverse flow diagnostic device
US4795698A (en) 1985-10-04 1989-01-03 Immunicon Corporation Magnetic-polymer particles
US5597531A (en) * 1985-10-04 1997-01-28 Immunivest Corporation Resuspendable coated magnetic particles and stable magnetic particle suspensions
US4855225A (en) 1986-02-07 1989-08-08 Applied Biosystems, Inc. Method of detecting electrophoretically separated oligonucleotides
US4810378A (en) * 1986-04-21 1989-03-07 Miles Laboratories, Inc. Red blood cell filtering system
US5252494A (en) 1986-06-25 1993-10-12 Trustees Of Tufts College Fiber optic sensors, apparatus, and detection methods using controlled release polymers and reagent formulations held within a polymeric reaction matrix
US5143853A (en) 1986-06-25 1992-09-01 Trustees Of Tufts College Absorbance modulated fluorescence detection methods and sensors
US4935346A (en) 1986-08-13 1990-06-19 Lifescan, Inc. Minimum procedure system for the determination of analytes
US4753776A (en) 1986-10-29 1988-06-28 Biotrack, Inc. Blood separation device comprising a filter and a capillary flow pathway exiting the filter
CH672383A5 (en) 1986-10-29 1989-11-15 Baumer Electric Ag
US4925800A (en) * 1986-12-04 1990-05-15 The United States Of America As Represented By The Department Of Health And Human Services Monoclonal antibody against human pneumocystis carinii
US4813277A (en) 1987-03-30 1989-03-21 Amoco Corporation Method for collecting magnetizable particles in an above ground storage tank
US4828386A (en) 1987-06-19 1989-05-09 Pall Corporation Multiwell plates containing membrane inserts
US4988618A (en) * 1987-11-16 1991-01-29 Gene-Trak Systems Magnetic separation device and methods for use in heterogeneous assays
US5209904A (en) 1987-12-23 1993-05-11 Abbott Laboratories Agglutination reaction device utilizing selectively impregnated porous material
US4938742A (en) * 1988-02-04 1990-07-03 Smits Johannes G Piezoelectric micropump with microvalves
US5162863A (en) 1988-02-15 1992-11-10 Canon Kabushiki Kaisha Method and apparatus for inspecting a specimen by optical detection of antibody/antigen sensitized carriers
US4874499A (en) 1988-05-23 1989-10-17 Massachusetts Institute Of Technology Electrochemical microsensors and method of making such sensors
US5252294A (en) * 1988-06-01 1993-10-12 Messerschmitt-Bolkow-Blohm Gmbh Micromechanical structure
US4908112A (en) 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
US5130238A (en) * 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
IT1226712B (en) 1988-08-05 1991-02-05 Eniricerche Spa IMMUNOENZYMATIC METHOD ELISA SINGLE PLATE WITH COMPETITIVE INHIBITION FOR THE DETECTION OF PLASMODIUM FALCIPARUM ANTI-SHORT ANTIBODIES.
US5108933A (en) 1988-09-16 1992-04-28 Immunicon Corporation Manipulation of colloids for facilitating magnetic separations
FR2638848B1 (en) * 1988-11-04 1993-01-22 Chemunex Sa METHOD OF DETECTION AND / OR DETERMINATION IN A LIQUID OR SEMI-LIQUID MEDIUM OF AT LEAST ONE ORGANIC, BIOLOGICAL OR MEDICINAL SUBSTANCE, BY AN AGGLUTINATION METHOD
IE67038B1 (en) 1988-12-22 1996-02-21 Patrick Joseph Joyce Immunodiagnostic assays for use in the detection and determination of mastitis
US6008031A (en) 1989-05-12 1999-12-28 Duke University Method of analysis and manipulation of DNA utilizing mismatch repair systems
US5156810A (en) 1989-06-15 1992-10-20 Biocircuits Corporation Biosensors employing electrical, optical and mechanical signals
US5491097A (en) * 1989-06-15 1996-02-13 Biocircuits Corporation Analyte detection with multilayered bioelectronic conductivity sensors
US5053197A (en) 1989-07-19 1991-10-01 Pb Diagnostic Systems, Inc. Diagnostic assay module
JP3127449B2 (en) 1989-07-28 2001-01-22 三菱化学株式会社 Antibody assay
US5698271A (en) * 1989-08-22 1997-12-16 Immunivest Corporation Methods for the manufacture of magnetically responsive particles
CA2024548C (en) * 1989-09-05 2002-05-28 David Issachar Analyte specific chemical sensor
US5541057A (en) * 1989-09-18 1996-07-30 Biostar, Inc. Methods for detection of an analyte
US5137833A (en) 1989-09-21 1992-08-11 Russell Anthony P Method for detecting polyhydroxyl compounds
US5366860A (en) 1989-09-29 1994-11-22 Applied Biosystems, Inc. Spectrally resolvable rhodamine dyes for nucleic acid sequence determination
US5188934A (en) 1989-11-14 1993-02-23 Applied Biosystems, Inc. 4,7-dichlorofluorescein dyes as molecular probes
US4997577A (en) 1989-12-20 1991-03-05 Baxter International Inc. Systems and methods for removing undesired matter from blood cells
US5547682A (en) * 1989-12-22 1996-08-20 Bioquest, Incorporated Preparation and use of novel injectable RES avoiding inorganic particles for medical application
US5183740A (en) * 1990-02-23 1993-02-02 The United States Of America As Represented By The Secretary Of The Navy Flow immunosensor method and apparatus
US5811387A (en) 1990-05-15 1998-09-22 Chiron Corporation Peptoid mixtures
US5182366A (en) 1990-05-15 1993-01-26 Huebner Verena D Controlled synthesis of peptide mixtures using mixed resins
US5240640A (en) * 1990-06-04 1993-08-31 Coulter Corporation In situ use of gelatin or an aminodextran in the preparation of uniform ferrite particles
US5223393A (en) * 1990-06-12 1993-06-29 Microgenics Corporation Detection of analytes having binding sites for at least two binding moieties
US5147606A (en) 1990-08-06 1992-09-15 Miles Inc. Self-metering fluid analysis device
US5071076A (en) 1990-08-10 1991-12-10 Omni Quest Corporation Method for producing magnetic microparticles from metallocenes
US5235028A (en) 1990-08-31 1993-08-10 University Of Minnesota Polyethylene glycol derivatives for solid-phase applications
US5250264A (en) * 1991-01-25 1993-10-05 Trustees Of Tufts College Method of making imaging fiber optic sensors to concurrently detect multiple analytes of interest in a fluid sample
US5244636A (en) 1991-01-25 1993-09-14 Trustees Of Tufts College Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a fluid sample
US5244813A (en) 1991-01-25 1993-09-14 Trustees Of Tufts College Fiber optic sensor, apparatus, and methods for detecting an organic analyte in a fluid or vapor sample
US5235039A (en) 1991-06-10 1993-08-10 Eli Lilly And Company Substrates for hiv protease
US5578444A (en) * 1991-06-27 1996-11-26 Genelabs Technologies, Inc. Sequence-directed DNA-binding molecules compositions and methods
ATE171543T1 (en) 1991-07-16 1998-10-15 Transmed Biotech Inc METHODS AND COMPOSITIONS FOR THE SIMULTANEOUS ANALYSIS OF A MULTIPLE ANALYTES
US5837552A (en) * 1991-07-22 1998-11-17 Medifor, Ltd. Surface-enhanced analytical procedures and substrates
US5211850A (en) 1991-07-26 1993-05-18 Research Medical, Inc. Plasma filter sorbent system for removal of components from blood
US5288214A (en) 1991-09-30 1994-02-22 Toshio Fukuda Micropump
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5677195A (en) * 1991-11-22 1997-10-14 Affymax Technologies N.V. Combinatorial strategies for polymer synthesis
JPH05157684A (en) 1991-12-02 1993-06-25 Seikagaku Kogyo Co Ltd Absorptionmeter
US6063581A (en) * 1992-01-22 2000-05-16 Axis-Shield Asa Immunoassay for homocysteine
US5262127A (en) * 1992-02-12 1993-11-16 The Regents Of The University Of Michigan Solid state chemical micro-reservoirs
US5654497A (en) 1992-03-03 1997-08-05 Lockheed Martin Energy Systems, Inc. Motor vehicle fuel analyzer
US5391272A (en) 1992-03-06 1995-02-21 Andcare, Inc. Electrochemical immunoassay methods
US5518887A (en) * 1992-03-30 1996-05-21 Abbott Laboratories Immunoassays empolying generic anti-hapten antibodies and materials for use therein
US5248742A (en) * 1992-04-27 1993-09-28 Gencorp Inc. Unsaturated polyester-epoxy resin network composition
US5587128A (en) 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5637469A (en) * 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5296375A (en) * 1992-05-01 1994-03-22 Trustees Of The University Of Pennsylvania Mesoscale sperm handling devices
US5278303A (en) 1992-06-12 1994-01-11 University Of Toronto Innovations Foundation Polymer-supported solution synthesis of oligosaccharides
US5674698A (en) * 1992-09-14 1997-10-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US5503985A (en) 1993-02-18 1996-04-02 Cathey; Cheryl A. Disposable device for diagnostic assays
US5677196A (en) 1993-05-18 1997-10-14 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
GB9311988D0 (en) 1993-06-10 1993-07-28 Pall Corp Device and method for separating plasma from a blood product
US6087186A (en) * 1993-07-16 2000-07-11 Irori Methods and apparatus for synthesizing labeled combinatorial chemistry libraries
US5382512A (en) 1993-08-23 1995-01-17 Chiron Corporation Assay device with captured particle reagent
FR2710410B1 (en) * 1993-09-20 1995-10-20 Bio Merieux Method and device for determining an analyte in a sample.
US5472672A (en) * 1993-10-22 1995-12-05 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and method for polymer synthesis using arrays
WO1995011755A1 (en) * 1993-10-28 1995-05-04 Houston Advanced Research Center Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions
US5499909A (en) 1993-11-17 1996-03-19 Aisin Seiki Kabushiki Kaisha Of Kariya Pneumatically driven micro-pump
DE69410487T2 (en) 1993-12-28 1998-11-05 Westonbridge Int Ltd MICRO PUMP
US5616698A (en) 1994-01-10 1997-04-01 University Of Toronto Innovations Foundation Polymer-supported solution synthesis of oligosaccharides
US5631130A (en) 1994-05-13 1997-05-20 Abbott Laboratories Materials and methods for the detection of Mycobacterium tuberculosis
US5583162A (en) * 1994-06-06 1996-12-10 Biopore Corporation Polymeric microbeads and method of preparation
DE69527585T2 (en) * 1994-06-08 2003-04-03 Affymetrix Inc Method and device for packaging chips
US5622821A (en) * 1994-06-29 1997-04-22 The Regents Of The University Of California Luminescent lanthanide chelates and methods of use
JPH0842457A (en) * 1994-07-27 1996-02-13 Aisin Seiki Co Ltd Micropump
US5512490A (en) 1994-08-11 1996-04-30 Trustees Of Tufts College Optical sensor, optical sensing apparatus, and methods for detecting an analyte of interest using spectral recognition patterns
US5965590A (en) 1994-09-08 1999-10-12 Romark Lab Lc Method for treatment of opportunistic infections with pharmaceutical compositions of tizoxanide and nitazoxanide
AUPM807094A0 (en) * 1994-09-09 1994-10-06 Commonwealth Scientific And Industrial Research Organisation Polymer beads and method for preparation thereof
US5603351A (en) * 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5632876A (en) 1995-06-06 1997-05-27 David Sarnoff Research Center, Inc. Apparatus and methods for controlling fluid flow in microchannels
EP0791238B1 (en) 1994-11-10 2004-09-22 Orchid BioSciences, Inc. Liquid distribution system
US5616790A (en) * 1994-11-18 1997-04-01 California Institute Of Technology Lipid-based metal sensor
US5550373A (en) * 1994-12-30 1996-08-27 Honeywell Inc. Fabry-Perot micro filter-detector
US5571401A (en) 1995-03-27 1996-11-05 California Institute Of Technology Sensor arrays for detecting analytes in fluids
US5834318A (en) 1995-05-10 1998-11-10 Bayer Corporation Screening of combinatorial peptide libraries for selection of peptide ligand useful in affinity purification of target proteins
US6524532B1 (en) * 1995-06-20 2003-02-25 The Regents Of The University Of California Microfabricated sleeve devices for chemical reactions
US6168948B1 (en) * 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
US5856174A (en) * 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5690807A (en) 1995-08-03 1997-11-25 Massachusetts Institute Of Technology Method for producing semiconductor particles
US5843655A (en) 1995-09-18 1998-12-01 Affymetrix, Inc. Methods for testing oligonucleotide arrays
US5863975A (en) 1995-10-03 1999-01-26 Rheox Inc. Aqueous construction compositions with improved water retention properties and a process for providing water retention properties to aqueous construction compositions
US5714122A (en) * 1995-11-22 1998-02-03 Minnesota Mining And Manufacturing Company Emulsion for robust sensing
US5705018A (en) * 1995-12-13 1998-01-06 Hartley; Frank T. Micromachined peristaltic pump
US5814524A (en) * 1995-12-14 1998-09-29 Trustees Of Tufts College Optical sensor apparatus for far-field viewing and making optical analytical measurements at remote locations
US6127139A (en) * 1996-01-04 2000-10-03 Nederlands Organisatle Voor Toegepast-Natuurwetenschappelijk Onderzoek (Tno) Method for assaying proteolytic enzymes using fluorescence-quenched substrates
JP3664328B2 (en) * 1996-01-19 2005-06-22 富士写真フイルム株式会社 Method for preparing plasma or serum sample
US6013440A (en) * 1996-03-11 2000-01-11 Affymetrix, Inc. Nucleic acid affinity columns
US5747349A (en) * 1996-03-20 1998-05-05 University Of Washington Fluorescent reporter beads for fluid analysis
US5788814A (en) * 1996-04-09 1998-08-04 David Sarnoff Research Center Chucks and methods for positioning multiple objects on a substrate
US5840256A (en) 1996-04-09 1998-11-24 David Sarnoff Research Center Inc. Plate for reaction system
US5879632A (en) * 1996-04-09 1999-03-09 Sarnoff Corporation Apportioning system
JPH09281045A (en) * 1996-04-10 1997-10-31 Kdk Corp Optical measurement of mevalonic acid
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
JP3950493B2 (en) * 1996-04-26 2007-08-01 東レ・ダウコーニング株式会社 Conductive silicone rubber composition, method for manufacturing semiconductor device, and semiconductor device
FR2749082B1 (en) * 1996-05-24 1998-06-26 Bio Merieux SUPERPARAMAGNETIC PARTICLES AND MONODISPERSEES
US6103479A (en) 1996-05-30 2000-08-15 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US5866430A (en) 1996-06-13 1999-02-02 Grow; Ann E. Raman optrode processes and devices for detection of chemicals and microorganisms
US5770370A (en) * 1996-06-14 1998-06-23 David Sarnoff Research Center, Inc. Nuclease protection assays
US5797898A (en) 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
GB2315131B (en) 1996-07-10 2000-11-29 Cambridge Imaging Ltd Improvements in and relating to imaging
US5707502A (en) * 1996-07-12 1998-01-13 Chiron Diagnostics Corporation Sensors for measuring analyte concentrations and methods of making same
US5854684A (en) * 1996-09-26 1998-12-29 Sarnoff Corporation Massively parallel detection
US5872623A (en) * 1996-09-26 1999-02-16 Sarnoff Corporation Massively parallel detection
US5861658A (en) * 1996-10-03 1999-01-19 International Business Machines Corporation Inorganic seal for encapsulation of an organic layer and method for making the same
US5748091A (en) 1996-10-04 1998-05-05 Mcdonnell Douglas Corporation Fiber optic ice detector
US6048732A (en) 1996-10-16 2000-04-11 Board Of Regents, The University Of Texas System Receptor and method for citrate determination
US6209589B1 (en) 1996-10-21 2001-04-03 Smithkline Beecham Plc Apparatus and method for distributing beads
US6083761A (en) 1996-12-02 2000-07-04 Glaxo Wellcome Inc. Method and apparatus for transferring and combining reagents
US5779907A (en) * 1996-12-06 1998-07-14 Systems Research Laboratories, Inc. Magnetic microplate separator
JP4663824B2 (en) * 1996-12-31 2011-04-06 ハイ スループット ジェノミクス インコーポレイテッド Multiplexed molecular analyzer and method
US6245331B1 (en) * 1997-01-02 2001-06-12 New York Univ. Medical Center Early detection of mycobacterial disease
US6413786B1 (en) * 1997-01-23 2002-07-02 Union Biometrica Technology Holdings, Inc. Binding assays using optical resonance of colloidal particles
US5827748A (en) * 1997-01-24 1998-10-27 The United States Of America As Represented By The Secretary Of The Navy Chemical sensor using two-dimensional lens array
US5981297A (en) 1997-02-05 1999-11-09 The United States Of America As Represented By The Secretary Of The Navy Biosensor using magnetically-detected label
US6037137A (en) * 1997-02-20 2000-03-14 Oncoimmunin, Inc. Fluorogenic peptides for the detection of protease activity
US6023540A (en) 1997-03-14 2000-02-08 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
US6045579A (en) * 1997-05-01 2000-04-04 Spinal Concepts, Inc. Adjustable height fusion device
US6406845B1 (en) * 1997-05-05 2002-06-18 Trustees Of Tuft College Fiber optic biosensor for selectively detecting oligonucleotide species in a mixed fluid sample
US6171780B1 (en) * 1997-06-02 2001-01-09 Aurora Biosciences Corporation Low fluorescence assay platforms and related methods for drug discovery
US6426050B1 (en) * 1997-05-16 2002-07-30 Aurora Biosciences Corporation Multi-well platforms, caddies, lids and combinations thereof
AU736321B2 (en) * 1997-05-23 2001-07-26 Lynx Therapeutics, Inc. System and apparatus for sequential processing of analytes
US5985120A (en) * 1997-06-12 1999-11-16 University Of Massachusetts Rapid analysis of analyte solutions
US7115884B1 (en) * 1997-10-06 2006-10-03 Trustees Of Tufts College Self-encoding fiber optic sensor
US5922617A (en) * 1997-11-12 1999-07-13 Functional Genetics, Inc. Rapid screening assay methods and devices
US5992820A (en) * 1997-11-19 1999-11-30 Sarnoff Corporation Flow control in microfluidics devices by controlled bubble formation
US6074616A (en) * 1998-01-05 2000-06-13 Biosite Diagnostics, Inc. Media carrier for an assay device
JP3468750B2 (en) * 1998-01-22 2003-11-17 ルミネックス コーポレイション Microparticles with multiple fluorescent signals
US6210910B1 (en) * 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
JP3944996B2 (en) 1998-03-05 2007-07-18 株式会社日立製作所 DNA probe array
JP3459770B2 (en) * 1998-04-10 2003-10-27 キヤノン株式会社 Image reading apparatus and method, recording medium
DE19825909C1 (en) * 1998-06-10 1999-11-25 Graffinity Pharm Design Gmbh Sample holder array for automated pharmaceutical laboratory tests
US6692696B1 (en) * 1998-06-18 2004-02-17 ARETé ASSOCIATES Biosensor
US6908770B1 (en) * 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US6601613B2 (en) * 1998-10-13 2003-08-05 Biomicro Systems, Inc. Fluid circuit components based upon passive fluid dynamics
US6136273A (en) * 1998-11-18 2000-10-24 Matrix Technologies Corporation Closure device for laboratory receptacles
US6151973A (en) * 1999-01-29 2000-11-28 Glaxo Wellcome Inc. Bead picking apparatus and method
WO2000052456A1 (en) * 1999-03-02 2000-09-08 Helix Biopharma Corporation Biosensor device and method
CN1185492C (en) * 1999-03-15 2005-01-19 清华大学 Single-point strobed micro electromagnetic units array chip or electromagnetic biologic chip and application thereof
US6355431B1 (en) * 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
US6410255B1 (en) * 1999-05-05 2002-06-25 Aurora Biosciences Corporation Optical probes and assays
US6485690B1 (en) * 1999-05-27 2002-11-26 Orchid Biosciences, Inc. Multiple fluid sample processor and system
US6258229B1 (en) * 1999-06-02 2001-07-10 Handani Winarta Disposable sub-microliter volume sensor and method of making
US6219566B1 (en) * 1999-07-13 2001-04-17 Photonics Research Ontario Method of measuring concentration of luminescent materials in turbid media
US7022517B1 (en) * 1999-07-16 2006-04-04 Board Of Regents, The University Of Texas System Method and apparatus for the delivery of samples to a chemical sensor array
US6589779B1 (en) * 1999-07-16 2003-07-08 Board Of Regents, The University Of Texas System General signaling protocol for chemical receptors in immobilized matrices
US6411207B2 (en) * 1999-10-01 2002-06-25 Avaya Technology Corp. Personal alert device
US6682649B1 (en) * 1999-10-01 2004-01-27 Sophion Bioscience A/S Substrate and a method for determining and/or monitoring electrophysiological properties of ion channels
US6254830B1 (en) * 1999-11-05 2001-07-03 The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations Magnetic focusing immunosensor for the detection of pathogens
US6309889B1 (en) * 1999-12-23 2001-10-30 Glaxo Wellcome Inc. Nano-grid micro reactor and methods
US6514415B2 (en) * 2000-01-31 2003-02-04 Dexter Magnetic Technologies, Inc. Method and apparatus for magnetic separation of particles
DE60135092D1 (en) * 2000-01-31 2008-09-11 Univ Texas PORTABLE DEVICE WITH A SENSOR ARRAY ARRANGEMENT
US6591124B2 (en) * 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
AU2003228711C1 (en) * 2002-04-26 2010-01-07 Board Of Regents, The University Of Texas System Method and system for the detection of cardiac risk factors
US8101431B2 (en) * 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
US8105849B2 (en) * 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
US20060257991A1 (en) * 2004-02-27 2006-11-16 Mcdevitt John T Integration of fluids and reagents into self-contained cartridges containing particle-based sensor elements and membrane-based sensor elements
US20090215646A1 (en) * 2005-07-01 2009-08-27 The Board Of Regents Of The University Of Texas Sy System and method of analyte detection using differential receptors

Also Published As

Publication number Publication date
US20080219891A1 (en) 2008-09-11
WO2001055701A9 (en) 2002-10-31
US20030064422A1 (en) 2003-04-03
AU2001238011A1 (en) 2001-08-07
US20030186228A1 (en) 2003-10-02
WO2001055952A2 (en) 2001-08-02
US20040053322A1 (en) 2004-03-18
CA2401782A1 (en) 2001-08-02
AU2001247195A1 (en) 2001-08-07
AU2001236597A1 (en) 2001-08-07
WO2001055703A1 (en) 2001-08-02
WO2001055952A9 (en) 2002-01-10
AU2001233200A1 (en) 2001-08-07
WO2001055702A9 (en) 2002-10-24
US7316899B2 (en) 2008-01-08
DE60135092D1 (en) 2008-09-11
US6713298B2 (en) 2004-03-30
EP2230314A1 (en) 2010-09-22
ATE403145T1 (en) 2008-08-15
EP1255980A1 (en) 2002-11-13
US20050136548A1 (en) 2005-06-23
AU2001234709A1 (en) 2001-08-07
WO2001055702A1 (en) 2001-08-02
US20110251075A1 (en) 2011-10-13
WO2001055704A1 (en) 2001-08-02
US6649403B1 (en) 2003-11-18
US20020045272A1 (en) 2002-04-18
WO2001055952A8 (en) 2002-05-16
EP1255980B1 (en) 2008-07-30
WO2001055701A1 (en) 2001-08-02
WO2001055703A9 (en) 2002-10-24

Similar Documents

Publication Publication Date Title
WO2001055704A8 (en) System for transferring fluid samples through a sensor array
AU1325201A (en) Detection system based on an analyte reactive particle
WO2002061392A3 (en) Method and apparatus for the confinement of materials in a micromachined chemical sensor array
WO2002103371A3 (en) Magnetic-based placement and retention of sensor elements in a sensor array
WO2005059551A3 (en) Method and system for the analysis of saliva using a sensor array
WO2003090605A3 (en) Method and system for the detection of cardiac risk factors
WO2005090983A3 (en) Membrane assay system including preloaded particles
WO2001040757A3 (en) Resonant optical cavities for high-sensitivity, high-throughput biological sensors and methods
WO2004085995A3 (en) Analyte concentration detection devices and methods
BR9811502B1 (en) pressure sensor, pressure measurement system and method for measuring the pressure applied to the sensor.
AU2001250883A1 (en) Method for detecting an analyte by fluorescence
ATE319080T1 (en) USE OF A SPATIO-TEMPORAL RESPONSE IN SENSOR ARRAYS FOR THE DETECTION OF ANALYTES IN FLUID
BR0214478A (en) Reading device, method and system for performing lateral flow tests
WO2007005666A3 (en) System and method of analyte detection using differential receptors
DE60128279D1 (en) Optical sensor for the detection of several analytes
CA2273585A1 (en) Sensors for detecting changes in temperature, ph, chemical conditions, biological conditions, radiation, electrical field and pressure
GB9212416D0 (en) Reversible binding substances
WO2001018524A3 (en) Methods for improving signal detection from an array
WO2006072043A3 (en) Label-independent detection of unpurified analytes
AU2002358915A1 (en) Integrated optoelectronic silicon biosensor for the detection of biomolecules labeled with chromophore groups or nanoparticles
CN101490554A (en) Method for sensing a chemical
WO2005116611A3 (en) Flow assay device comprising dry reagent cake
WO2001069248A3 (en) An immunoassay diagnostic probe and its use
WO2002059599A3 (en) System and method for in vitro analysis of therapeutic agents
WO2001086285A3 (en) Direct detection of individual molecules

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: C1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: C1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP