WO2001057239A2 - Reagent test strip for analyte determination - Google Patents
Reagent test strip for analyte determinationInfo
- Publication number
- WO2001057239A2 WO2001057239A2 PCT/US2001/002547 US0102547W WO0157239A2 WO 2001057239 A2 WO2001057239 A2 WO 2001057239A2 US 0102547 W US0102547 W US 0102547W WO 0157239 A2 WO0157239 A2 WO 0157239A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- test strip
- analyte
- glucose
- concentration
- producing system
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G01N33/521—Single-layer analytical elements
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Definitions
- the field of this invention is analyte determination, particular blood analyte determination and more particularly blood glucose determination Background
- Analyte detection in physiological fluids e g blood or blood derived products such as plasma
- Analyte detection assays find use in a variety of applications and settings, including the clinical laboratory testing, home testing, etc , where the results of such testing play a prominent role in diagnosis and management in a variety of disease conditions
- Analytes of interest include glucose for diabetes management, cholesterol for monitoring cardiovascular conditions, and the like
- analyte detection protocols and devices for both clinical and home use have been developed
- analyte detection assays are based on the production of hydrogen peroxide and the subsequent detection thereof
- Analytes that may be detected using such assays include cholesterol, triglycerides, glucose, ethanol and lactic acid
- glucose is quantitated using such assays by first oxidizing glucose with glucose oxidase to produce gluconic acid and hydrogen peroxide
- the resultant hydrogen peroxide in conjunction with a peroxidase, causes the conversion of one or more organic substrates, i e an indicator, into a chromogenic product, which product is then detected and related to the glucose concentration in the initial sample
- Hydrogen peroxide based assays such as the glucose assay described above, are subject to problems which result from the presence of erythrocyte components, e g catalase, that interfere with the hydrogen peroxide based reaction and therefore alter (for example reduce) the signal that is ultimately obtained and used to derive the analyte concentration
- erythrocyte components e g catalase
- Many different protocols have been developed which are designed to at least reduce the potential analytical error that is introduced in the assay through the release of interfering erythrocyte components via hemolysis
- Such protocols include filtration, filtration combined with the addition of inhibitors, filtration and trapping of erythrocytes, and the use of asymmetric non-hemolyzing membranes While such methods can partially remove the analytical error introduced by hemolysis, they are not entirely satisfactory For example, filtration typically requires longer assay times and larger sample sizes than is desirable
- U S Patent documents of interest include 4,297,238, 5,258,047, 5,563,042, 5,753,452, 5,789,255, 5,843,691, 5,866,349, 5,968,836 and 5,972,294 Also of interest are WO 90/12889, WO 90/12890, JP 3180762, JP 62296987, and EP 0 638 805
- the subject reagent test strips include one or more members of an analyte oxidation signal producing system and at least one hemolyzing agent
- the subject reagent test strips and methods are particularly suited for use in the detection of blood glucose concentrations
- kits that include the subject test strips for use in practicing the subject methods
- FIGURES Fig 1 provides a graphical representation of the effect of hemolysate on test response
- Figs 2a provides a graphical representation of the effect of hematocrit on test response in the absence of a hemolyzing agent
- Fig 2b provides a graphical representation of the effect of hematocrit on test response in the presence of 0 25 % CTAC
- Figs 3 and 4 provide graphical representations of the test response and reaction kinetics observed at a whole blood glucose concentration of 390 mg/dL in the absence and presence of 0 25 % CTAC
- Figs 5 and 6 provide graphical representations of the test response and reaction kinetics observed at a whole blood glucose concentration of 390 mg/dL in the absence and presence of 0 25 %
- Figs 7 and 8 provide graphical representations of the test response and reaction kinetics observed at a whole blood glucose concentration of 390 mg/dL in the absence and presence of 0 50 % Brij-58
- Fig 9 provides a graphical representation of the test response and reaction kinetics observed at a whole blood glucose concentration of 390 mg/dL in the presence of 0 50% Lubrol PX
- Fig 10 provides a graphical representation of the variation in observed K/S in the presence and absence of 0 25% CTAC in 60 % Hct blood having a 0 0 mg/dL glucose concentration
- Fig 11 provides a graphical representation of the variation in observed K/S in the presence and absence of 0 25% CTAC in 60 % Hct blood having a 30 mg/dL glucose concentration
- the subject test strips include a porous matrix, one or more members of an analyte oxidation signal producing system and at least one hemolyzing agent
- a physiological sample is applied to the test strip
- the appearance of a chromogenic product of the signal producing system is detected and related to the concentration of the analyte in the sample
- kits for practicing the subject methods where the kits at least include the subject reagent test strips.
- the reagent test strips of the subject invention are characterized by having at least the following components: a porous matrix; one or more members of an analyte oxidation signal producing system; and at least one hemolyzing agent.
- a porous matrix characterized by having at least the following components: a porous matrix; one or more members of an analyte oxidation signal producing system; and at least one hemolyzing agent.
- the matrix that is employed in the subject test strips is an inert porous matrix which provides a support for the various members of the signal producing system, described infra, as well as the light absorbing or chromogenic product produced by the signal producing system, i.e. the indicator.
- the inert porous matrix is configured to provide a location for physiological sample, e.g. blood, application and a location for detection of the light- absorbing product produced by the indicator of the signal producing system.
- the inert porous matrix is one that is permissive of aqueous fluid flow through it and provides sufficient void space for the chemical reactions of the signal producing system to take place.
- porous matrices have been developed for use in various analyte detection assays, which matrices may differ in terms of materials, pore sizes, dimensions and the like, where representative matrices include those described in: 4,734,360; 4,900,666; 4,935,346; 5,059,394; 5,304,468; 5,306,623; 5,418,142; 5,426,032; 5,515, 170; 5,526,120; 5,563,042; 5,620,863; 5,753,429; 5,573,452; 5,780,304; 5,789,255; 5,843,691; 5,846,486; 5,968,836 and 5,972,294; the disclosures of which are herein incorporated by reference.
- the nature of the porous matrix is not critical to the subject test strips and therefore is chosen with respect to the other factors, including the nature of the instrument which is used to read the test strip, convenience and the like.
- the dimensions and porosity of the test strip may vary greatly, where the matrix may or may not have a porosity gradient, e.g. with larger pores near or at the sample application region and smaller pores at the detection region.
- Materials from which the matrix may be fabricated vary, and include polymers, e.g. polysulfone, polyamides, cellulose or absorbent paper , and the like, where the material may or may not be functionalized to provide for covalent or non-covalent attachment of the various members of the signal producing system, described in greater detail infra
- the subject test strips further include one or more members of a signal producing system which produces a detectable product in response to the presence of analyte, which detectable product can be used to derive the amount of analyte present in the assayed sample
- the one or more members of the signal producing system are associated, e g covalently or non-covalently attached to, at least a portion of (i e the detection region) the porous matrix, and in many embodiments to substantially all of the porous matrix
- the signal producing system is an analyte oxidation signal producing system
- analyte oxidation signal producing system is meant that in generating the detectable signal from which the analyte concentration in the sample is derived, the analyte is oxidized by a suitable enzyme to produce an oxidized form of the analyte and a corresponding or proportional amount of hydrogen peroxide
- the hydrogen peroxide is then employed, in turn, to generate the detectable product from one or more indicator compounds, where the amount of detectable product producing by the signal producing system, i e the signal, is then related to the amount of analyte in the initial sample
- the analyte oxidation signal producing systems present in the subject test strips are also correctly characterized as hydrogen peroxide based signal producing systems
- the hydrogen peroxide based signal producing systems include an enzyme that oxidizes the analyte and produces a corresponding amount of hydrogen peroxide, where by corresponding amount is meant that the amount of hydrogen peroxide that is produced is proportional to the amount of analyte present in the sample
- This first enzyme necessarily depends on the nature of the analyte being assayed but is generally an oxidase
- the first enzyme may be glucose oxidase (where the analyte is glucose), cholesterol oxidase (where the analyte is cholesterol), alcohol oxidase (where the analyte is alcohol), lactate oxidase (where the analyte is lactate) and the like
- the first enzyme is glucose oxidase
- the glucose oxidase may be obtained from any convenient source, e g a naturally occurring source such as Aspergillus niger or Penicillum, or recombinantly produced
- the second enzyme of the signal producing system is an enzyme that catalyzes the conversion of one or more indicator compounds into a detectable product in the presence of hydrogen peroxide, where the amount of detectable product that is produced by this reaction is proportional to the amount of hydrogen peroxide that is present
- This second enzyme is generally a peroxidase, where suitable peroxidases include horseradish peroxidase (HRP), soy peroxidase, recombinantly produced peroxidase and synthetic analogs having peroxidative activity and the like See e g , Y Ci, F Wang, Analytica Chimica Acta, 233 (1990), 299-302
- the indicator compound or compounds, e g substrates are ones that are either formed or decomposed by the hydrogen peroxide in the presence of the peroxidase to produce an indicator dye that absorbs light in a predetermined wavelength range
- the indicator dye absorbs strongly at a wavelength different from that at which the sample or the testing reagent absorbs strongly
- the oxidized form of the indicator may be the colored, faintly-colored, or colorless final product that evidences a change in color of the testing side of the membrane That is to say, the testing reagent can indicate the presence of glucose in a sample by a colored area being bleached or, alternatively, by a colorless area developing color
- Indicator compounds that are useful in the present invention include both one- and two-component chromogenic substrates
- One-component systems include aromatic amines, aromatic alcohols, azines, and benzidines, such as tetramethyl benzidine-HCl
- Suitable two- component systems include those in which one component is MBTH, an MBTH derivative (see for example those disclosed in U S patent application Ser No 08/302,575, incorporated herein by reference), or 4-am ⁇ noantipyrine and the other component is an aromatic amine, aromatic alcohol, conjugated amine, conjugated alcohol or aromatic or aliphatic aldehyde
- Exemplary two-component systems are 3-methyl-2-benzothiazolinone hydrazone hydrochloride (MBTH) combined with 3-dimethylaminobenzoic acid (DMAB), MBTH combined with 3,5-d ⁇ chloro-2-hydroxybenzene-sulfonic acid (DCHBS), and 3- methyl-2-benzothiazolinone hydrazone N
- hemolyzing agent an agent that is capable of lysing erythrocytes or red blood cells Any convenient hemolyzing agent may be employed, where a variety of different hemolyzing agents are known to those of skill in the art
- Representative hemolyzing agents of interest include ionic surface-active agents, both anionic and cationic, and non-ionic surface active agents, where particular surfactants of interest include sodium dodecylsulfate, cetyltrimethylammonium bromide, laurylsarcosine or tauroglycocholate, alkylphenol polyglycol ethers, e g polyoxyethylene-10-octylphenol ether (Triton® X 100), polyoxyethylene-7 8-octylphenol ether (Triton® X 114), polyoxyethylene-10-nonylphenol ether (Renex®690), polyoxyethylene-9-nonylphenol ether (R
- the subject test strips may include one type of hemolyzing agent, or may include two or more different types of hemolyzing agents, e g a plurality of different hemolyzing agents
- the strips generally include from two to five different hemolyzing agents, and usually from two to four different hemolyzing agents
- the total amount of the one or more hemolyzing agents that is included in the test strip is chosen to produce hemolysis which is equivalent to at least about 5% hemolysate by volume in the sample usually at least about 8% and in many embodiments at least about 10% hemolysate in the sample, e g plasma fraction, that is ultimately present in the detection region following sample application
- the amount of hemolyzing agent(s) present in the test strip is sufficient to provide from about 5 to 40, usually from about 8 to 30 and more usually from about 10 to 20 % (v/v) hemolysate in the sample, e g plasma fraction, that is present in the detection region of the strip
- the subject test strips are methods of using the subject test strips to determine the concentration of an analyte in a physiological sample
- analytes include glucose, cholesterol, lactate, alcohol, and the like
- the subject methods are employed to determine the glucose concentration in a physiological sample While in principle the subject methods may be used to determine the concentration of an analyte in a variety of different physiological samples, such as urine, tears, saliva, and the like, they are particularly suited for use in determining the concentration of an analyte in blood or blood fractions, e g blood derived samples, and more particularly in whole blood
- the first step is to apply a quantity of the physiological sample to the test strip, where the test strip is described supra
- the amount of physiological sample, e g blood, that is applied to the test strip may vary, but generally ranges from about 2 ⁇ L to 40 ⁇ L, usually from about 5 ⁇ L to 20 ⁇ L Because of the nature of the subject test strip
- kits for use in practicing the subject methods at least include a reagent test strip that includes a hemolyzing agent, as described above
- the subject kits may further include a means for obtaining a physiological sample
- the subject kits may further include a means for obtaining a blood sample, such as a lance for sticking a finger, a lance actuation means, and the like
- the subject kits may include a control solution or standard, e g a glucose control solution that contains a standardized concentration of glucose
- the kits also include an automated instrument, as described above, for detecting the amount of product produced on the strip following sample application and related the detected product to the amount of analyte in the sample
- the kits include instructions for using the subject reagent test strips in the determination of an analyte concentration in a physiological sample These instructions may be present on one or more of the packaging, a label insert, containers present in the kits, and the like
- Fig 1 shows the effect of hemolysis on the meter response
- Fig 1 demonstrates that most of the decrease in color formation due to competing reactions is produced by hemolysis in the rang of 0 to 8% and the response remains constant at the range of 10 to 20% hemolysis.
- a certain a nount of hemolyzing surfactant to the reagent formulation, one can ensure that blood samphs applied to the strip are hemolyzed in the range of 10 to 20% across the range of potential hematocrit. This range of hemolysis allows for analyte calibration that is unaffected by the level of hematocrit. See Figs. 2a and 2b.
- Figs. 3 and 4 provide the observed test response and reaction kinetics for a control and 0.25% CTAC strip at a whole blood concentration of 390 mg/dL.
- Figs. 5 and 6 provide the observed test response and reaction kinetics for a control and 0.25% Triton X-100 strip at a whole blood concentration of 390 mg/dL.
- Figs. 7 and 8 provide the observed test response and reaction kinetics for a control and 0.50% Brij-58 strip at a whole blood concentration of 390 mg/dL; while Fig.
- FIG. 9 provides the observed test response and reaction kinetics for a 0.50% Lubrol PX strip at a whole blood glucose concentration of 390 mg/dL.
- Figs. 10 and 11 demonstrate the hemolyzing effect of the CTAC surfactants as indicated by a higher absorbance at the hemoglobin's Soret band (around 400 nm) in the presence of CTAC. Visual confirmation of the test results is a beneficial feature offered by the SureStep system.
- Figure 10 shows that hemolysis at the range required in this invention does not cause increased blood color (red appearance) in the visual range even when high hematocrit sample is applied to the strip, and therefore will not interfere with the visual confirmation of the test results.
- the subject invention provides for a significant improvement in hematocrit performance with respect to analytical error results from erythrocyte based interfering components.
- the subject invention provides for these improved results without requiring an initially large physiological sample or a long assay time. As such, the subject invention represents a significant contribution to the art.
Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020027009675A KR20020073190A (en) | 2000-02-02 | 2001-01-25 | Reagent test strip for analyte determination |
IL14966501A IL149665A0 (en) | 2000-02-02 | 2001-01-25 | Reagent test strip for analyte determination |
MXPA02005798A MXPA02005798A (en) | 2000-02-02 | 2001-01-25 | Reagent test strip for analyte determination. |
AU32991/01A AU783251B2 (en) | 2000-02-02 | 2001-01-25 | Reagent test strip for analyte determination |
PL01358137A PL358137A1 (en) | 2000-02-02 | 2001-01-25 | Reagent test strip for analyte determination |
JP2001555862A JP2003521246A (en) | 2000-02-02 | 2001-01-25 | Reagent test strips for analyte measurement |
CA002388283A CA2388283A1 (en) | 2000-02-02 | 2001-01-25 | Reagent test strip for analyte determination |
EP01905073A EP1252515A2 (en) | 2000-02-02 | 2001-01-25 | Reagent test strip for analyte determination |
HK03101792.5A HK1049699A1 (en) | 2000-02-02 | 2003-03-12 | Reagent test strip for analyte determination |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/497,631 | 2000-02-02 | ||
US09/497,631 US6485923B1 (en) | 2000-02-02 | 2000-02-02 | Reagent test strip for analyte determination having hemolyzing agent |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001057239A2 true WO2001057239A2 (en) | 2001-08-09 |
WO2001057239A3 WO2001057239A3 (en) | 2002-03-14 |
Family
ID=23977641
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/002547 WO2001057239A2 (en) | 2000-02-02 | 2001-01-25 | Reagent test strip for analyte determination |
Country Status (16)
Country | Link |
---|---|
US (3) | US6485923B1 (en) |
EP (1) | EP1252515A2 (en) |
JP (1) | JP2003521246A (en) |
KR (1) | KR20020073190A (en) |
CN (1) | CN1207393C (en) |
AR (1) | AR027346A1 (en) |
AU (1) | AU783251B2 (en) |
CA (1) | CA2388283A1 (en) |
CZ (1) | CZ20022945A3 (en) |
HK (1) | HK1049699A1 (en) |
IL (1) | IL149665A0 (en) |
MX (1) | MXPA02005798A (en) |
MY (1) | MY133942A (en) |
PL (1) | PL358137A1 (en) |
RU (1) | RU2002113055A (en) |
WO (1) | WO2001057239A2 (en) |
Cited By (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6759190B2 (en) | 2002-06-15 | 2004-07-06 | Acon Laboratories, Inc. | Test strip for detection of analyte and methods of use |
US7323315B2 (en) | 2003-02-11 | 2008-01-29 | Bayer Healthcare Llc | Method for reducing effect of hematocrit on measurement of an analyte in whole blood |
US7727467B2 (en) | 2003-06-20 | 2010-06-01 | Roche Diagnostics Operations, Inc. | Reagent stripe for test strip |
EP2319937A1 (en) * | 2008-07-23 | 2011-05-11 | Nippon Kayaku Kabushiki Kaisha | Blood component measurement method utilizing hemolyzed whole blood, and kit for the method |
US7972861B2 (en) | 2004-05-14 | 2011-07-05 | Bayer Healthcare Llc | Methods for performing hematocrit adjustment in glucose assays and devices for same |
US8071030B2 (en) | 2003-06-20 | 2011-12-06 | Roche Diagnostics Operations, Inc. | Test strip with flared sample receiving chamber |
US8287703B2 (en) | 1999-10-04 | 2012-10-16 | Roche Diagnostics Operations, Inc. | Biosensor and method of making |
US8298828B2 (en) | 2003-06-20 | 2012-10-30 | Roche Diagnostics Operations, Inc. | System and method for determining the concentration of an analyte in a sample fluid |
CN102884429A (en) * | 2010-03-01 | 2013-01-16 | 系统生物股份有限公司 | Test strip for the detection of equol |
US8507289B1 (en) | 2003-06-20 | 2013-08-13 | Roche Diagnostics Operations, Inc. | System and method for coding information on a biosensor test strip |
US8663442B2 (en) | 2003-06-20 | 2014-03-04 | Roche Diagnostics Operations, Inc. | System and method for analyte measurement using dose sufficiency electrodes |
CN103630535A (en) * | 2013-12-03 | 2014-03-12 | 上海科华生物工程股份有限公司 | Dry chemical test paper for quantitatively determining content of human blood albumin |
US9039975B2 (en) | 2006-03-31 | 2015-05-26 | Abbott Diabetes Care Inc. | Analyte monitoring devices and methods therefor |
US9042953B2 (en) | 1998-04-30 | 2015-05-26 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US9066709B2 (en) | 2009-01-29 | 2015-06-30 | Abbott Diabetes Care Inc. | Method and device for early signal attenuation detection using blood glucose measurements |
US9066695B2 (en) | 1998-04-30 | 2015-06-30 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US9066697B2 (en) | 1998-04-30 | 2015-06-30 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US9078607B2 (en) | 2005-11-01 | 2015-07-14 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
WO2016014162A1 (en) | 2014-07-25 | 2016-01-28 | Becton, Dickinson And Company | Analyte test strip assays, and test strips and kits for use in practicing the same |
US9320461B2 (en) | 2009-09-29 | 2016-04-26 | Abbott Diabetes Care Inc. | Method and apparatus for providing notification function in analyte monitoring systems |
US9410915B2 (en) | 2004-06-18 | 2016-08-09 | Roche Operations Ltd. | System and method for quality assurance of a biosensor test strip |
US9610034B2 (en) | 2001-01-02 | 2017-04-04 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US9649057B2 (en) | 2007-05-08 | 2017-05-16 | Abbott Diabetes Care Inc. | Analyte monitoring system and methods |
US9730584B2 (en) | 2003-06-10 | 2017-08-15 | Abbott Diabetes Care Inc. | Glucose measuring device for use in personal area network |
US9743863B2 (en) | 2006-03-31 | 2017-08-29 | Abbott Diabetes Care Inc. | Method and system for powering an electronic device |
US9801545B2 (en) | 2007-03-01 | 2017-10-31 | Abbott Diabetes Care Inc. | Method and apparatus for providing rolling data in communication systems |
US9949678B2 (en) | 2007-05-08 | 2018-04-24 | Abbott Diabetes Care Inc. | Method and device for determining elapsed sensor life |
US9962091B2 (en) | 2002-12-31 | 2018-05-08 | Abbott Diabetes Care Inc. | Continuous glucose monitoring system and methods of use |
US9968306B2 (en) | 2012-09-17 | 2018-05-15 | Abbott Diabetes Care Inc. | Methods and apparatuses for providing adverse condition notification with enhanced wireless communication range in analyte monitoring systems |
US9968302B2 (en) | 2009-08-31 | 2018-05-15 | Abbott Diabetes Care Inc. | Analyte signal processing device and methods |
US9980669B2 (en) | 2011-11-07 | 2018-05-29 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods |
US10039881B2 (en) | 2002-12-31 | 2018-08-07 | Abbott Diabetes Care Inc. | Method and system for providing data communication in continuous glucose monitoring and management system |
US10201301B2 (en) | 2005-11-01 | 2019-02-12 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US10429250B2 (en) | 2009-08-31 | 2019-10-01 | Abbott Diabetes Care, Inc. | Analyte monitoring system and methods for managing power and noise |
US10478108B2 (en) | 1998-04-30 | 2019-11-19 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US11793936B2 (en) | 2009-05-29 | 2023-10-24 | Abbott Diabetes Care Inc. | Medical device antenna systems having external antenna configurations |
Families Citing this family (97)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6036924A (en) * | 1997-12-04 | 2000-03-14 | Hewlett-Packard Company | Cassette of lancet cartridges for sampling blood |
US8071384B2 (en) | 1997-12-22 | 2011-12-06 | Roche Diagnostics Operations, Inc. | Control and calibration solutions and methods for their use |
US6391005B1 (en) | 1998-03-30 | 2002-05-21 | Agilent Technologies, Inc. | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
US8346337B2 (en) | 1998-04-30 | 2013-01-01 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US6485923B1 (en) * | 2000-02-02 | 2002-11-26 | Lifescan, Inc. | Reagent test strip for analyte determination having hemolyzing agent |
US8641644B2 (en) | 2000-11-21 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
US7041468B2 (en) | 2001-04-02 | 2006-05-09 | Therasense, Inc. | Blood glucose tracking apparatus and methods |
US7749174B2 (en) | 2001-06-12 | 2010-07-06 | Pelikan Technologies, Inc. | Method and apparatus for lancet launching device intergrated onto a blood-sampling cartridge |
DE60234598D1 (en) | 2001-06-12 | 2010-01-14 | Pelikan Technologies Inc | SELF-OPTIMIZING LANZET DEVICE WITH ADAPTANT FOR TEMPORAL FLUCTUATIONS OF SKIN PROPERTIES |
US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
ATE485766T1 (en) | 2001-06-12 | 2010-11-15 | Pelikan Technologies Inc | ELECTRICAL ACTUATING ELEMENT FOR A LANCET |
EP1404234B1 (en) * | 2001-06-12 | 2011-02-09 | Pelikan Technologies Inc. | Apparatus for improving success rate of blood yield from a fingerstick |
US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7025774B2 (en) | 2001-06-12 | 2006-04-11 | Pelikan Technologies, Inc. | Tissue penetration device |
US7682318B2 (en) * | 2001-06-12 | 2010-03-23 | Pelikan Technologies, Inc. | Blood sampling apparatus and method |
US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
US7981056B2 (en) | 2002-04-19 | 2011-07-19 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
CA2419213C (en) * | 2002-03-07 | 2011-06-21 | Bayer Healthcare Llc | Improved electrical sensor |
US7175642B2 (en) | 2002-04-19 | 2007-02-13 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
US8579831B2 (en) | 2002-04-19 | 2013-11-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7976476B2 (en) | 2002-04-19 | 2011-07-12 | Pelikan Technologies, Inc. | Device and method for variable speed lancet |
US8360992B2 (en) | 2002-04-19 | 2013-01-29 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7909778B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7547287B2 (en) | 2002-04-19 | 2009-06-16 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7410468B2 (en) * | 2002-04-19 | 2008-08-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8784335B2 (en) | 2002-04-19 | 2014-07-22 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling device with a capacitive sensor |
US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
US7491178B2 (en) | 2002-04-19 | 2009-02-17 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7563232B2 (en) * | 2002-04-19 | 2009-07-21 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8221334B2 (en) | 2002-04-19 | 2012-07-17 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US9795334B2 (en) | 2002-04-19 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7648468B2 (en) | 2002-04-19 | 2010-01-19 | Pelikon Technologies, Inc. | Method and apparatus for penetrating tissue |
US7371247B2 (en) * | 2002-04-19 | 2008-05-13 | Pelikan Technologies, Inc | Method and apparatus for penetrating tissue |
US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7141058B2 (en) * | 2002-04-19 | 2006-11-28 | Pelikan Technologies, Inc. | Method and apparatus for a body fluid sampling device using illumination |
US7717863B2 (en) | 2002-04-19 | 2010-05-18 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7331931B2 (en) | 2002-04-19 | 2008-02-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7481776B2 (en) * | 2002-04-19 | 2009-01-27 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7485128B2 (en) * | 2002-04-19 | 2009-02-03 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7291117B2 (en) | 2002-04-19 | 2007-11-06 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7674232B2 (en) | 2002-04-19 | 2010-03-09 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7297122B2 (en) | 2002-04-19 | 2007-11-20 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7232451B2 (en) | 2002-04-19 | 2007-06-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7229458B2 (en) | 2002-04-19 | 2007-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7226461B2 (en) | 2002-04-19 | 2007-06-05 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with sterility barrier release |
US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
US7901362B2 (en) * | 2002-04-19 | 2011-03-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8267870B2 (en) | 2002-04-19 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling with hybrid actuation |
US7892185B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
US7892183B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
US8574895B2 (en) | 2002-12-30 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
AU2003300154A1 (en) * | 2002-12-31 | 2004-07-29 | Pelikan Technologies Inc. | Method and apparatus for loading penetrating members |
EP1628567B1 (en) | 2003-05-30 | 2010-08-04 | Pelikan Technologies Inc. | Method and apparatus for fluid injection |
DK1633235T3 (en) | 2003-06-06 | 2014-08-18 | Sanofi Aventis Deutschland | Apparatus for sampling body fluid and detecting analyte |
WO2006001797A1 (en) | 2004-06-14 | 2006-01-05 | Pelikan Technologies, Inc. | Low pain penetrating |
WO2005006939A2 (en) * | 2003-06-11 | 2005-01-27 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
US7718439B2 (en) | 2003-06-20 | 2010-05-18 | Roche Diagnostics Operations, Inc. | System and method for coding information on a biosensor test strip |
US7645373B2 (en) | 2003-06-20 | 2010-01-12 | Roche Diagnostic Operations, Inc. | System and method for coding information on a biosensor test strip |
US8206565B2 (en) | 2003-06-20 | 2012-06-26 | Roche Diagnostics Operation, Inc. | System and method for coding information on a biosensor test strip |
US7488601B2 (en) | 2003-06-20 | 2009-02-10 | Roche Diagnostic Operations, Inc. | System and method for determining an abused sensor during analyte measurement |
US8679853B2 (en) | 2003-06-20 | 2014-03-25 | Roche Diagnostics Operations, Inc. | Biosensor with laser-sealed capillary space and method of making |
US7645421B2 (en) | 2003-06-20 | 2010-01-12 | Roche Diagnostics Operations, Inc. | System and method for coding information on a biosensor test strip |
US8282576B2 (en) | 2003-09-29 | 2012-10-09 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for an improved sample capture device |
EP1680014A4 (en) | 2003-10-14 | 2009-01-21 | Pelikan Technologies Inc | Method and apparatus for a variable user interface |
US7365720B2 (en) * | 2003-12-23 | 2008-04-29 | Barco N.V. | Colour calibration of emissive display devices |
US7822454B1 (en) | 2005-01-03 | 2010-10-26 | Pelikan Technologies, Inc. | Fluid sampling device with improved analyte detecting member configuration |
EP1706026B1 (en) | 2003-12-31 | 2017-03-01 | Sanofi-Aventis Deutschland GmbH | Method and apparatus for improving fluidic flow and sample capture |
EP1713926B1 (en) | 2004-02-06 | 2012-08-01 | Bayer HealthCare, LLC | Oxidizable species as an internal reference for biosensors and method of use |
US8828203B2 (en) | 2004-05-20 | 2014-09-09 | Sanofi-Aventis Deutschland Gmbh | Printable hydrogels for biosensors |
US9775553B2 (en) | 2004-06-03 | 2017-10-03 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
EP1765194A4 (en) | 2004-06-03 | 2010-09-29 | Pelikan Technologies Inc | Method and apparatus for a fluid sampling device |
US8652831B2 (en) | 2004-12-30 | 2014-02-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte measurement test time |
KR101321296B1 (en) | 2005-07-20 | 2013-10-28 | 바이엘 헬스케어 엘엘씨 | Gated amperometry temperature determination |
JP5671205B2 (en) | 2005-09-30 | 2015-02-18 | バイエル・ヘルスケア・エルエルシー | Gated voltammetry |
WO2007044599A2 (en) * | 2005-10-06 | 2007-04-19 | Hamilton Scott E | Pod connected data monitoring system |
US7766829B2 (en) | 2005-11-04 | 2010-08-03 | Abbott Diabetes Care Inc. | Method and system for providing basal profile modification in analyte monitoring and management systems |
US7993512B2 (en) | 2006-07-11 | 2011-08-09 | Bayer Healthcare, Llc | Electrochemical test sensor |
US8930203B2 (en) | 2007-02-18 | 2015-01-06 | Abbott Diabetes Care Inc. | Multi-function analyte test device and methods therefor |
US8461985B2 (en) | 2007-05-08 | 2013-06-11 | Abbott Diabetes Care Inc. | Analyte monitoring system and methods |
US7928850B2 (en) | 2007-05-08 | 2011-04-19 | Abbott Diabetes Care Inc. | Analyte monitoring system and methods |
WO2009076302A1 (en) | 2007-12-10 | 2009-06-18 | Bayer Healthcare Llc | Control markers for auto-detection of control solution and methods of use |
WO2009076271A2 (en) * | 2007-12-10 | 2009-06-18 | Bayer Healthcare Llc | Wear-resistant electrochemical test sensor and method of forming the same |
WO2009126900A1 (en) | 2008-04-11 | 2009-10-15 | Pelikan Technologies, Inc. | Method and apparatus for analyte detecting device |
US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
US9226701B2 (en) | 2009-04-28 | 2016-01-05 | Abbott Diabetes Care Inc. | Error detection in critical repeating data in a wireless sensor system |
US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
TWI414432B (en) * | 2011-07-08 | 2013-11-11 | Microjet Technology Co Ltd | Manufacturing method of conductive layer of blood glucose test strips |
EP3581925A1 (en) | 2013-03-14 | 2019-12-18 | Instrumentation Laboratory Company | Whole blood hemolysis sensor |
US9121050B2 (en) | 2013-03-15 | 2015-09-01 | American Sterilizer Company | Non-enzyme based detection method for electronic monitoring of biological indicator |
US8858884B2 (en) | 2013-03-15 | 2014-10-14 | American Sterilizer Company | Coupled enzyme-based method for electronic monitoring of biological indicator |
CN105954270A (en) * | 2016-04-27 | 2016-09-21 | 樊福好 | Solution for evaluating glucose metabolism based on sialology method and evaluation method thereof |
US20180295158A1 (en) * | 2017-04-05 | 2018-10-11 | Microsoft Technology Licensing, Llc | Displaying group expressions for teleconference sessions |
CN109187121A (en) * | 2018-08-06 | 2019-01-11 | 中国人民解放军第三0二医院 | Reagent and its application in combined immunization effect early stage fast appraisement method |
KR102136193B1 (en) * | 2019-10-28 | 2020-07-21 | 주식회사 원드롭 | Strip for measuring hemoglobin concentration |
CN112014573B (en) * | 2020-08-25 | 2023-08-08 | 武汉生之源生物科技股份有限公司 | Preparation method of high-sensitivity assay kit for troponin I in human whole blood sample and kit |
WO2023112442A1 (en) * | 2021-12-13 | 2023-06-22 | テルモ株式会社 | Biological component concentration measurement reagent, measurement method, and sensor |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3424355A1 (en) * | 1983-07-06 | 1985-01-17 | Kabushiki Kaisha Kyoto Daiichi Kagaku, Kyoto | Analytical aid with a plurality of layers combined to form a unit, and method for analysing a liquid sample |
DE4229477A1 (en) * | 1992-09-03 | 1994-03-10 | Miles Inc | Prepn. of a highly porous membrane - by selective removal of polymers; useful as testing strips in urine analysis |
EP0695936A2 (en) * | 1994-08-03 | 1996-02-07 | TOA MEDICAL ELECTRONICS CO., Ltd. | A method for classifying and counting leukocytes |
EP0708335A2 (en) * | 1994-10-19 | 1996-04-24 | Fuji Photo Film Co., Ltd. | Dry analytical element containing ampholyte |
US5705357A (en) * | 1994-08-29 | 1998-01-06 | Johnson & Johnson Clinical Diagnostics, Inc. | Chemiluminescent reagent and assay using a substituted acetanilide for light generation |
EP0840124A2 (en) * | 1996-10-31 | 1998-05-06 | Kyoto Daiichi Kagaku Co., Ltd. | Analytical element with dry reagent |
US5891731A (en) * | 1996-04-12 | 1999-04-06 | Toa Medical Electronics Co., Ltd. | Reagent for measuring reticulocytes and a method of measuring them |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE708335C (en) | 1939-03-26 | 1941-07-18 | Gertrud Recknagel | Duvet holder, especially for cots, consisting of a belt that can be folded around the mattress |
DE695936C (en) | 1939-03-28 | 1940-09-06 | Wilhelm Stoehr Maschinenfabrik | |
DE840124C (en) | 1942-10-23 | 1952-05-29 | Cfcmug | Arrangement on cathode ray tubes |
DE2850603A1 (en) * | 1978-11-22 | 1980-06-19 | Merck Patent Gmbh | HAEMOLYSIS SOLUTION AND METHOD FOR HAEMOLYSING BLOOD |
DE3303098A1 (en) * | 1983-01-31 | 1984-08-02 | Boehringer Mannheim Gmbh, 6800 Mannheim | METHOD AND REAGENT FOR DETERMINING GLUCOSE IN HAEMOLYSED BLOOD |
JPS62296987A (en) | 1986-08-06 | 1987-12-24 | Amada Co Ltd | Laser beam machine |
US4935346A (en) | 1986-08-13 | 1990-06-19 | Lifescan, Inc. | Minimum procedure system for the determination of analytes |
SE466158B (en) | 1989-04-25 | 1992-01-07 | Migrata Uk Ltd | METHOD OF ANALYSIS FOR GLUCOSE DETERMINATION IN WHOLE BLOOD |
SE466157B (en) | 1989-04-25 | 1992-01-07 | Migrata Uk Ltd | DETERMINED TO DETERMINE THE GLUCOSE CONTENT OF WHOLE BLOOD AND DISPOSABLE BEFORE THIS |
JP2614124B2 (en) | 1989-12-08 | 1997-05-28 | 富士写真フイルム株式会社 | Integrated multilayer analytical element |
JP3064409B2 (en) | 1990-11-30 | 2000-07-12 | 株式会社日立製作所 | Holding device and semiconductor manufacturing apparatus using the same |
DE4206932A1 (en) * | 1992-03-05 | 1993-09-09 | Boehringer Mannheim Gmbh | IMMUNOLOGICAL METHOD FOR DETERMINING A HAEMOGLOBIN DERIVATIVE |
GR1002549B (en) | 1992-05-12 | 1997-01-28 | Lifescan Inc. | Fluid conducting test strip with Transport Medium |
US5843691A (en) | 1993-05-15 | 1998-12-01 | Lifescan, Inc. | Visually-readable reagent test strip |
CA2127172C (en) | 1993-08-05 | 1998-07-14 | Amy H. Chu | Analyte detection device and process |
US5695949A (en) * | 1995-04-07 | 1997-12-09 | Lxn Corp. | Combined assay for current glucose level and intermediate or long-term glycemic control |
AU722471B2 (en) | 1995-10-17 | 2000-08-03 | Lifescan, Inc. | Blood glucose strip having reduced sensitivity to hematocrit |
US5753452A (en) | 1996-04-04 | 1998-05-19 | Lifescan, Inc. | Reagent test strip for blood glucose determination |
IL120587A (en) | 1996-04-04 | 2000-10-31 | Lifescan Inc | Reagent test strip for determination of blood glucose |
US6485923B1 (en) * | 2000-02-02 | 2002-11-26 | Lifescan, Inc. | Reagent test strip for analyte determination having hemolyzing agent |
-
2000
- 2000-02-02 US US09/497,631 patent/US6485923B1/en not_active Expired - Lifetime
-
2001
- 2001-01-25 AU AU32991/01A patent/AU783251B2/en not_active Ceased
- 2001-01-25 MX MXPA02005798A patent/MXPA02005798A/en active IP Right Grant
- 2001-01-25 CN CNB018033369A patent/CN1207393C/en not_active Expired - Fee Related
- 2001-01-25 RU RU2002113055/15A patent/RU2002113055A/en not_active Application Discontinuation
- 2001-01-25 JP JP2001555862A patent/JP2003521246A/en active Pending
- 2001-01-25 PL PL01358137A patent/PL358137A1/en not_active Application Discontinuation
- 2001-01-25 IL IL14966501A patent/IL149665A0/en unknown
- 2001-01-25 KR KR1020027009675A patent/KR20020073190A/en not_active Application Discontinuation
- 2001-01-25 CZ CZ20022945A patent/CZ20022945A3/en unknown
- 2001-01-25 CA CA002388283A patent/CA2388283A1/en not_active Abandoned
- 2001-01-25 EP EP01905073A patent/EP1252515A2/en not_active Ceased
- 2001-01-25 WO PCT/US2001/002547 patent/WO2001057239A2/en not_active Application Discontinuation
- 2001-01-31 MY MYPI20010424A patent/MY133942A/en unknown
- 2001-02-01 AR ARP010100477A patent/AR027346A1/en unknown
-
2002
- 2002-05-24 US US10/155,949 patent/US6989243B2/en not_active Expired - Lifetime
-
2003
- 2003-03-12 HK HK03101792.5A patent/HK1049699A1/en unknown
-
2004
- 2004-11-30 US US11/001,490 patent/US6998248B2/en not_active Expired - Lifetime
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3424355A1 (en) * | 1983-07-06 | 1985-01-17 | Kabushiki Kaisha Kyoto Daiichi Kagaku, Kyoto | Analytical aid with a plurality of layers combined to form a unit, and method for analysing a liquid sample |
DE4229477A1 (en) * | 1992-09-03 | 1994-03-10 | Miles Inc | Prepn. of a highly porous membrane - by selective removal of polymers; useful as testing strips in urine analysis |
EP0695936A2 (en) * | 1994-08-03 | 1996-02-07 | TOA MEDICAL ELECTRONICS CO., Ltd. | A method for classifying and counting leukocytes |
US5705357A (en) * | 1994-08-29 | 1998-01-06 | Johnson & Johnson Clinical Diagnostics, Inc. | Chemiluminescent reagent and assay using a substituted acetanilide for light generation |
EP0708335A2 (en) * | 1994-10-19 | 1996-04-24 | Fuji Photo Film Co., Ltd. | Dry analytical element containing ampholyte |
US5891731A (en) * | 1996-04-12 | 1999-04-06 | Toa Medical Electronics Co., Ltd. | Reagent for measuring reticulocytes and a method of measuring them |
EP0840124A2 (en) * | 1996-10-31 | 1998-05-06 | Kyoto Daiichi Kagaku Co., Ltd. | Analytical element with dry reagent |
Cited By (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9066695B2 (en) | 1998-04-30 | 2015-06-30 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US9066697B2 (en) | 1998-04-30 | 2015-06-30 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US9042953B2 (en) | 1998-04-30 | 2015-05-26 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US9066694B2 (en) | 1998-04-30 | 2015-06-30 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US10478108B2 (en) | 1998-04-30 | 2019-11-19 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US8287703B2 (en) | 1999-10-04 | 2012-10-16 | Roche Diagnostics Operations, Inc. | Biosensor and method of making |
US8551308B2 (en) | 1999-10-04 | 2013-10-08 | Roche Diagnostics Operations, Inc. | Biosensor and method of making |
US9610034B2 (en) | 2001-01-02 | 2017-04-04 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US6759190B2 (en) | 2002-06-15 | 2004-07-06 | Acon Laboratories, Inc. | Test strip for detection of analyte and methods of use |
US9962091B2 (en) | 2002-12-31 | 2018-05-08 | Abbott Diabetes Care Inc. | Continuous glucose monitoring system and methods of use |
US10039881B2 (en) | 2002-12-31 | 2018-08-07 | Abbott Diabetes Care Inc. | Method and system for providing data communication in continuous glucose monitoring and management system |
US10750952B2 (en) | 2002-12-31 | 2020-08-25 | Abbott Diabetes Care Inc. | Continuous glucose monitoring system and methods of use |
US7323315B2 (en) | 2003-02-11 | 2008-01-29 | Bayer Healthcare Llc | Method for reducing effect of hematocrit on measurement of an analyte in whole blood |
US9730584B2 (en) | 2003-06-10 | 2017-08-15 | Abbott Diabetes Care Inc. | Glucose measuring device for use in personal area network |
US8071030B2 (en) | 2003-06-20 | 2011-12-06 | Roche Diagnostics Operations, Inc. | Test strip with flared sample receiving chamber |
US7829023B2 (en) | 2003-06-20 | 2010-11-09 | Roche Diagnostics Operations, Inc. | Test strip with vent opening |
US8119414B2 (en) | 2003-06-20 | 2012-02-21 | Roche Diagnostics Operations, Inc. | Test strip with slot vent opening |
US8507289B1 (en) | 2003-06-20 | 2013-08-13 | Roche Diagnostics Operations, Inc. | System and method for coding information on a biosensor test strip |
US8142721B2 (en) | 2003-06-20 | 2012-03-27 | Roche Diagnostics Operations, Inc. | Test strip with slot vent opening |
US8586373B2 (en) | 2003-06-20 | 2013-11-19 | Roche Diagnostics Operations, Inc. | System and method for determining the concentration of an analyte in a sample fluid |
US8663442B2 (en) | 2003-06-20 | 2014-03-04 | Roche Diagnostics Operations, Inc. | System and method for analyte measurement using dose sufficiency electrodes |
US8222044B2 (en) | 2003-06-20 | 2012-07-17 | Roche Diagnostics Operations, Inc. | Test strip with flared sample receiving chamber |
US8211379B2 (en) | 2003-06-20 | 2012-07-03 | Roche Diagnostics Operations, Inc. | Test strip with slot vent opening |
US7879618B2 (en) | 2003-06-20 | 2011-02-01 | Roche Diagnostics Operations, Inc. | Method and reagent for producing narrow, homogenous reagent strips |
US8298828B2 (en) | 2003-06-20 | 2012-10-30 | Roche Diagnostics Operations, Inc. | System and method for determining the concentration of an analyte in a sample fluid |
US7749437B2 (en) | 2003-06-20 | 2010-07-06 | Roche Diagnostics Operations, Inc. | Method and reagent for producing narrow, homogenous reagent stripes |
US7727467B2 (en) | 2003-06-20 | 2010-06-01 | Roche Diagnostics Operations, Inc. | Reagent stripe for test strip |
US7972861B2 (en) | 2004-05-14 | 2011-07-05 | Bayer Healthcare Llc | Methods for performing hematocrit adjustment in glucose assays and devices for same |
US9410915B2 (en) | 2004-06-18 | 2016-08-09 | Roche Operations Ltd. | System and method for quality assurance of a biosensor test strip |
US10952652B2 (en) | 2005-11-01 | 2021-03-23 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US11911151B1 (en) | 2005-11-01 | 2024-02-27 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US11399748B2 (en) | 2005-11-01 | 2022-08-02 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US10231654B2 (en) | 2005-11-01 | 2019-03-19 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US10201301B2 (en) | 2005-11-01 | 2019-02-12 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US11103165B2 (en) | 2005-11-01 | 2021-08-31 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US11272867B2 (en) | 2005-11-01 | 2022-03-15 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US11363975B2 (en) | 2005-11-01 | 2022-06-21 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US9078607B2 (en) | 2005-11-01 | 2015-07-14 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US9039975B2 (en) | 2006-03-31 | 2015-05-26 | Abbott Diabetes Care Inc. | Analyte monitoring devices and methods therefor |
US9743863B2 (en) | 2006-03-31 | 2017-08-29 | Abbott Diabetes Care Inc. | Method and system for powering an electronic device |
US9625413B2 (en) | 2006-03-31 | 2017-04-18 | Abbott Diabetes Care Inc. | Analyte monitoring devices and methods therefor |
US9801545B2 (en) | 2007-03-01 | 2017-10-31 | Abbott Diabetes Care Inc. | Method and apparatus for providing rolling data in communication systems |
US10178954B2 (en) | 2007-05-08 | 2019-01-15 | Abbott Diabetes Care Inc. | Analyte monitoring system and methods |
US11696684B2 (en) | 2007-05-08 | 2023-07-11 | Abbott Diabetes Care Inc. | Analyte monitoring system and methods |
US9649057B2 (en) | 2007-05-08 | 2017-05-16 | Abbott Diabetes Care Inc. | Analyte monitoring system and methods |
US10952611B2 (en) | 2007-05-08 | 2021-03-23 | Abbott Diabetes Care Inc. | Analyte monitoring system and methods |
US9949678B2 (en) | 2007-05-08 | 2018-04-24 | Abbott Diabetes Care Inc. | Method and device for determining elapsed sensor life |
US10653317B2 (en) | 2007-05-08 | 2020-05-19 | Abbott Diabetes Care Inc. | Analyte monitoring system and methods |
US8883439B2 (en) | 2008-07-23 | 2014-11-11 | Nippon Kayaku Kabushiki Kaisha | Blood component measurement method utilizing hemolyzed whole blood, and kit for the method |
EP2319937A1 (en) * | 2008-07-23 | 2011-05-11 | Nippon Kayaku Kabushiki Kaisha | Blood component measurement method utilizing hemolyzed whole blood, and kit for the method |
EP2319937A4 (en) * | 2008-07-23 | 2011-08-17 | Nippon Kayaku Kk | Blood component measurement method utilizing hemolyzed whole blood, and kit for the method |
US9066709B2 (en) | 2009-01-29 | 2015-06-30 | Abbott Diabetes Care Inc. | Method and device for early signal attenuation detection using blood glucose measurements |
US11793936B2 (en) | 2009-05-29 | 2023-10-24 | Abbott Diabetes Care Inc. | Medical device antenna systems having external antenna configurations |
US11872370B2 (en) | 2009-05-29 | 2024-01-16 | Abbott Diabetes Care Inc. | Medical device antenna systems having external antenna configurations |
US11150145B2 (en) | 2009-08-31 | 2021-10-19 | Abbott Diabetes Care Inc. | Analyte monitoring system and methods for managing power and noise |
US11635332B2 (en) | 2009-08-31 | 2023-04-25 | Abbott Diabetes Care Inc. | Analyte monitoring system and methods for managing power and noise |
US10429250B2 (en) | 2009-08-31 | 2019-10-01 | Abbott Diabetes Care, Inc. | Analyte monitoring system and methods for managing power and noise |
US9968302B2 (en) | 2009-08-31 | 2018-05-15 | Abbott Diabetes Care Inc. | Analyte signal processing device and methods |
US10349874B2 (en) | 2009-09-29 | 2019-07-16 | Abbott Diabetes Care Inc. | Method and apparatus for providing notification function in analyte monitoring systems |
US9320461B2 (en) | 2009-09-29 | 2016-04-26 | Abbott Diabetes Care Inc. | Method and apparatus for providing notification function in analyte monitoring systems |
US9750439B2 (en) | 2009-09-29 | 2017-09-05 | Abbott Diabetes Care Inc. | Method and apparatus for providing notification function in analyte monitoring systems |
CN102884429A (en) * | 2010-03-01 | 2013-01-16 | 系统生物股份有限公司 | Test strip for the detection of equol |
CN102884429B (en) * | 2010-03-01 | 2014-11-19 | 系统生物股份有限公司 | Test strip for the detection of equol |
US9980669B2 (en) | 2011-11-07 | 2018-05-29 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods |
US11612363B2 (en) | 2012-09-17 | 2023-03-28 | Abbott Diabetes Care Inc. | Methods and apparatuses for providing adverse condition notification with enhanced wireless communication range in analyte monitoring systems |
US9968306B2 (en) | 2012-09-17 | 2018-05-15 | Abbott Diabetes Care Inc. | Methods and apparatuses for providing adverse condition notification with enhanced wireless communication range in analyte monitoring systems |
CN103630535A (en) * | 2013-12-03 | 2014-03-12 | 上海科华生物工程股份有限公司 | Dry chemical test paper for quantitatively determining content of human blood albumin |
EP3172570A4 (en) * | 2014-07-25 | 2017-12-27 | Becton, Dickinson and Company | Analyte test strip assays, and test strips and kits for use in practicing the same |
WO2016014162A1 (en) | 2014-07-25 | 2016-01-28 | Becton, Dickinson And Company | Analyte test strip assays, and test strips and kits for use in practicing the same |
Also Published As
Publication number | Publication date |
---|---|
US20020192733A1 (en) | 2002-12-19 |
RU2002113055A (en) | 2004-08-20 |
US6998248B2 (en) | 2006-02-14 |
US6485923B1 (en) | 2002-11-26 |
IL149665A0 (en) | 2002-11-10 |
KR20020073190A (en) | 2002-09-19 |
AU3299101A (en) | 2001-08-14 |
AU783251B2 (en) | 2005-10-06 |
JP2003521246A (en) | 2003-07-15 |
PL358137A1 (en) | 2004-08-09 |
AR027346A1 (en) | 2003-03-26 |
HK1049699A1 (en) | 2003-05-23 |
MY133942A (en) | 2007-11-30 |
WO2001057239A3 (en) | 2002-03-14 |
US20050095659A1 (en) | 2005-05-05 |
CA2388283A1 (en) | 2001-08-09 |
US6989243B2 (en) | 2006-01-24 |
CN1394281A (en) | 2003-01-29 |
MXPA02005798A (en) | 2003-10-14 |
CZ20022945A3 (en) | 2003-04-16 |
EP1252515A2 (en) | 2002-10-30 |
CN1207393C (en) | 2005-06-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU783251B2 (en) | Reagent test strip for analyte determination | |
US6586199B2 (en) | Stabilized tetrazolium reagent compositions and methods for using the same | |
US6939685B2 (en) | Stabilized tetrazolium phenazine reagent compositions and methods for using the same | |
US5453360A (en) | Oxidative coupling dye for spectrophotometric quantitive analysis of analytes | |
AU782774B2 (en) | Diagnostics based on tetrazolium compounds | |
AU714671B2 (en) | Chemical timer for a visual test strip | |
US5972294A (en) | Reagent test strip for determination of blood glucose | |
EP1305624A2 (en) | Compositions containing a urea derivative dye for detecting an analyte | |
AU628751B2 (en) | Composition and method of assaying for ketone bodies | |
AU4474399A (en) | Diagnostics based on tetrazolium compounds | |
WO2002022855A2 (en) | Test-strips with positively charged membranes for tetrazolium based assays | |
US5340539A (en) | Non-instrumented cholesterol assay | |
US5776779A (en) | Integral multi-layer element for analyzing bile acid sulfate | |
US8202490B2 (en) | Membranes and methods for coating membranes | |
JP3779048B2 (en) | Dry analytical element for the determination of cholinesterase |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
WWE | Wipo information: entry into national phase |
Ref document number: 32991/01 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1020027005917 Country of ref document: KR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2001905073 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2388283 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 149665 Country of ref document: IL |
|
ENP | Entry into the national phase |
Ref document number: 2002 2002113055 Country of ref document: RU Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: IN/PCT/2002/834/CHE Country of ref document: IN |
|
WWE | Wipo information: entry into national phase |
Ref document number: PA/a/2002/005798 Country of ref document: MX |
|
WWE | Wipo information: entry into national phase |
Ref document number: 018033369 Country of ref document: CN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1020027009675 Country of ref document: KR |
|
ENP | Entry into the national phase |
Ref document number: 2001 555862 Country of ref document: JP Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: PV2002-2945 Country of ref document: CZ |
|
WWP | Wipo information: published in national office |
Ref document number: 1020027009675 Country of ref document: KR |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 1020027005917 Country of ref document: KR |
|
WWP | Wipo information: published in national office |
Ref document number: 2001905073 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWP | Wipo information: published in national office |
Ref document number: PV2002-2945 Country of ref document: CZ |
|
WWG | Wipo information: grant in national office |
Ref document number: 32991/01 Country of ref document: AU |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 1020027009675 Country of ref document: KR |
|
WWR | Wipo information: refused in national office |
Ref document number: 2001905073 Country of ref document: EP |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 2001905073 Country of ref document: EP |