WO2001058349A1 - Pacifier pulse oximeter sensor - Google Patents
Pacifier pulse oximeter sensor Download PDFInfo
- Publication number
- WO2001058349A1 WO2001058349A1 PCT/US2001/004343 US0104343W WO0158349A1 WO 2001058349 A1 WO2001058349 A1 WO 2001058349A1 US 0104343 W US0104343 W US 0104343W WO 0158349 A1 WO0158349 A1 WO 0158349A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nipple
- recited
- light
- light source
- oximeter sensor
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6852—Catheters
- A61B5/6855—Catheters with a distal curved tip
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14552—Details of sensors specially adapted therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
- A61B5/412—Detecting or monitoring sepsis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
- A61B5/6814—Head
- A61B5/682—Mouth, e.g., oral cavity; tongue; Lips; Teeth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6887—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient mounted on external non-worn devices, e.g. non-medical devices
- A61B5/6896—Toys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J17/00—Baby-comforters; Teething rings
- A61J17/001—Baby-comforters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J17/00—Baby-comforters; Teething rings
- A61J17/10—Details; Accessories therefor
- A61J17/101—Emitting means, e.g. for emitting sound, light, scents or flavours
- A61J17/1012—Emitting light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J17/00—Baby-comforters; Teething rings
- A61J17/10—Details; Accessories therefor
- A61J17/105—Nipple attachments
Definitions
- This invention is directed to an apparatus and a method for measuring blood oxygenation from locations within the oral cavity of a subject, for example, a small child or a small/newborn animal More particularly, the invention relates to using pulse oximeter sensors to perform reflective pulse oximetry within the oral cavity of a subject
- Transillumination pulse oximetry without question, is the most effective form when oximetry is obtained through skin
- reflectance pulse oximetry easily can be achieved with very accurate results Indeed, it is used commonly and effectively among intrapartum and neonatal patients whose capillary beds are easily accessed through their skin
- the technique has also been applied to adult and pediat ⁇ c burn patients by placing the reflectance sensor in wounds or over hyperemic sites such as healed partial thickness burns
- the effect is achieved by the backscatte ⁇ ng of incident bispectral light that traverses and, on reflection from nonabsorptive collagenous tissues, retraverses formed elements in the blood back to the oximeter elements Rather than superseding transillumination pulse oximetry, this technique broadens the scope of possible monitoring sites, adding to the clinician's armamentarium
- Prior pulse oximeter sensors inserted through the mouth are usable only when the patient is under general anesthesia These pulse oximeter sensors are inserted to reach the larynx area, for example, U S Patent No 5,282,464 to Brain et al
- Another known method uses transillumination pulse oximetry of the posterior tongue but this method possibly may not be used with a patient, who is awake, for example U S Patent No 5,205,281 to Buchanan Also, the posterior tongue is not the most accessible body part to take oximetry measurements
- Another object of the invention is the use of reflectance pulse oximetry via the oral cavity for a variety of surgical, anesthetic, or critical care procedures or situations to include patients that are awake, undergoing general anesthesia, or recovering from
- Another object of the invention is to allow for lingual placement of a pulse oximeter sensor for reflectance readings to provide efficient and clinically accurate
- Another object of the invention is to allow for buccal placement of a pulse oximeter sensor for reflectance readings to provide efficient and clinically accurate pulse oximetry measurements
- Yet another object of the invention is to monitor oxygen levels in newborns and young children who are difficult to monitor because of their natural restlessness and young age
- Still another object of the invention is to monitor oxygen levels in severely burned ICU patients who are difficult to monitor
- Another advantage of the invention is that EMS crews and personnel will be able to use this invention easily in the field during, for example, emergency situations
- the apparatus to perform this method is extremely useful in cases where it is difficult at best or not even possible to attach prior art pulse oximeter sensors with clips or straps to the patient
- the types of patients that this apparatus would be useful with are critically ill or injured patients including newborns, babies, young children young animals, and burn or trauma patients without alternative sites and maxillofacial injuries
- Figure 1 depicts a side view of the preferred embodiment of the invention
- Figure 2 illustrates a side cross-section of a nipple of the preferred embodiment of the invention
- Figures 3-10 depict side cross-sections of a nipple to illustrate various alternative placements and arrangements of pulse oximeter elements according to the invention
- FIGS. 1 1-16 illustrate top views of various alternative placements and arrangements of the pulse oximeter elements according to the invention
- Figures 17 and 18 depict the invention in use in a subject
- Figures 19 and 20 illustrate cross-sections of examples of attaching the nipple to the shield for the preferred embodiment of the invention
- Figures 21(a)-(b) depict an example of a shield structure for use in the preferred embodiment of the invention
- Figure 22 illustrates a top view of an alternative embodiment of the invention
- Figure 23 depicts a top cross-section of another alternative embodiment of the invention.
- Figure 24 illustrates a rear view of the alternative embodiment of the invention illustrated in Figure 23
- Figure 25 depicts a block diagram for an alternative embodiment of the invention illustrated in Figures 23 and 24
- Figure 26 illustrates a top view of another alternative embodiment of the invention
- Figure 27 depicts a flowchart illustrating the steps for performing the preferred embodiment V. DETAILED DESCRIPTION OF THE INVENTION
- Figures 1-18 illustrate a preferred embodiment and alternative component arrangements of the pacifier oximeter sensor assembly
- the assembly preferably includes a pacifier 10, pulse oximeter sensor elements 20, 22, and wiring 24
- the pacifier 10 preferably includes a nipple (or baglet) 12 and a shield (or guard) 14
- the nipple 12 may be a variety of shapes in addition to those shown in
- nipple 12 Exemplary shapes for the nipple 12 include orthodontic, bottle nipple, spherical, and thumb shaped
- the nipple 12 preferably is a flexible material typically used to make pacifiers and baby bottle nipples such as polypropylene, polyvinyl chloride, si cones, epoxies, polyester, thermoplastics, rubber, or similar flexible material
- the material used to make the nipple 12 will be at least partially translucent to allow light to
- the nipple 12 will have an inner cavity 124 formed as a void in the nipple material 122
- the nipple 12 may be solid or filled with a flexible material to increase the protection of the pulse oximeter sensor elements 20, 22 and wiring 24
- the pulse oximeter sensor elements 20, 22 preferably are within the material 122 making up the nipple 12 to reduce the impact of the material 122 on the transmission of light through the material 122
- the pulse oximeter sensor elements 20, 22 may be nested within the nipple material 122 as shown, for example, in Figure 4 or the pulse oximeter sensor elements 20, 22 may abut the nipple material 122 on the inner cavity surface as shown, for example, in Figure 3
- the pulse oximeter sensor elements 20, 22 preferably will be placed in a position to transmit light and receive backscattered light from a capillary bed within the oral cavity of the subject as illustrated, for example, in Figures 17 and 18
- the preferred locations are along the top of the nipple 12 ( Figures 2-4), at the tip of the nipple 12 ( Figure 5), and along the bottom of the nipple 12 ( Figure 6)
- the pulse oximeter elements 20, 22 may be located in and/or along the nipple shank
- the pulse oximeter sensor elements include a light source 20 and a light detector 22
- the placement and location of the light source 20 and the light detector 22 depicted in Figures 1-18 may be switched with respect to each other
- the light source 20 and the light detector 22 may be in a variety of exemplary spatial locations relative to each other as shown, for example, in Figures 11-16
- Figures 11-16 illustrated the pulse oximeter sensor elements 20, 22 on the top of the nipple 12 these elements may have similar spatial locations on other portions of the nipple 12 such as the tip, bottom, and along the shank 126
- the light source 20 preferably emits at least two frequencies of light in the red region, for example with a wavelength of 660 nm, and in the infrared region, for example with a wavelength of 940 nm, preferably in response to a signal from a spectrophotometer, other similar oximeter monitoring devices or multiparameter patient monitoring systems that provide oximetry readings
- the light source 20 preferably is one or more of the following two light emitters such as light emitting diodes (LED), a bispectral emitter, a dual spectral emitter, a photoemitter, or a semiconductor die
- any light source that facilitates reflectance pulse oximetry may be employed
- the two emitter arrangement will include a red LED around or at 660 nm and a near-infrared LED emitting in the range of 890 to 950 nm and more particularly at about 940 nm
- the light source 20 may emit light having a bandwidth, for example, in the range of 20 to 50 nm
- the light detector 22 detects light emitted by the light source 20 Signals representing the detected light are transmitted by the light detector 22 to a spectrophotometer, an oximeter monitoring device or a multiparameter patient monitoring system that provides oximetry readings by discriminating between the relative intensity of these emissions and provides an index as to the degree of oxygen saturation of hemoglobin in blood
- the light detector 22 may be one of the following a photoelectric receiver, a photodetector, or a semiconductor die
- the wiring 24 preferably includes conductive lines and contact electrodes
- the wiring 24 preferably is embedded within the nipple material 122, or passes through the nipple cavity 124, or some combination of these two
- An external cord 26 preferably is insulated and connects to the wiring 24 at a proximal end of the pacifier 126 so that the external cord 26 is outside of the oral cavity of the subject
- the external cord 26 preferably includes a standard plug design to interface with a pulse oximetry spectrophotometer, a pulse monitor such as a plethysmograph, or other external
- the external cord 26 may be a jack to connect to a reusable cable such as the cable sold with the Nellcor® OxiChq® systems (Mal nckrodt, Inc , St
- the nipple 12 preferably is attached or mounted to the shield 14
- An example of one type of mounting is integrally forming the nipple 12 with the shield 14, for example by mechanically coupling the nipple 12 to the shield 14
- Another mounting arrangement, as illustrated in Figure 19, is to have the nipple 12 include a shank 126 with two integral spaced collars 1262, 1264 to form a channel to receive the shield 14
- the shield 14 is at or near the proximal end of the shank 126
- a handle 16 is looped through the shank 126' as illustrated in Figure 19
- the shield 14 includes an opening for the nipple shank 126 to pass through preferably such that a nm or section of rolled up material 1266 is located on the proximal side of the shield 14
- a plug 18 is inserted into the shield opening 142 to hold the nipple shank 126 in place with respect to the shield 14
- the plug 18 will include a securing mechanism that is compressed as it travels through the shield opening 142 and then expands on the distal side of the shield 14 to secure the plug 18 in place and hold the nipple 12 securely to the shield 14
- the shield 14 preferably is curved or bowed to form fit to the average baby's face
- the shield 14 may be any shape that prevents it from being pulled into the subject's mouth from the suction force placed upon the nipple 12 by the subject More preferably, the shield 14 will be shaped or include a reference indicator such that the top of the pacifier 10 can be readily determined by looking at the shield 14
- the shield 14 preferably includes a plurality of holes (or relief openings) 142 to allow for spit to be discharged without interference from the pacifier
- Figure 21 (b) illustrates a relief opening 142 that allows insertion of a catheter such as an endotracheal tube
- Figure 21 (b) illustrates a relief opening 142 that allows insertion of a catheter such as an endotracheal tube
- the shield is for the shield to include a mesh pattern over at least a portion of it
- the ring is hinged, collapsible, and/or flexible
- the oximeter signal processing device preferably is a miniature spectrophotometer
- the oximeter signal processing device preferably will include a display 32, a power supply (such as a battery) 34, and a processor 36 to perform calculations and to drive the display 32, and an on-off button (or switch/mechanism) 38 as illustrated in Figure 25
- the display 32 preferably will show the blood oxygenation level of the subject as illustrated in Figure 24 More preferably, the display 32 is a digital display
- the processor 36 preferably will connect to the wiring 24 running from the pulse oximeter sensor elements 20, 22, calculate the blood oxygenation level, and drive both the display 32 and the light source 20
- the processor 36 preferably is a circuit that includes either an analog circuit or an integrated circuit, which is either hardwired or programmed
- the display 32, the power supply 34, the processor 36 will reside on a
- the light source 20 and the light detector 22 may be in wireless communication with the external device instead of connected with the external cord 26 as illustrated in Figure 26 as a rod (or antenna or transmitter) 40
- the antenna 40 may take the shape as a handle 16 similar to the one illustrated, for example, in Figures 21 and 22 without the external cord 26
- the wireless communication will occur through an antenna 40 extending away from the pacifier 10
- the transmitter may be incorporated within the antenna 40 or some other housing incorporated into the shield 14
- the antenna 40 will be sufficiently sturdy to withstand tugging and being played with during use by the subject
- This alternative embodiment also preferably includes a power source such as a battery to power all of the electrical components
- the power source preferably is located within the shield, a housing, or as part of the antenna 40
- a further alternative embodiment of the invention is to provide a bite block on the distal side of the shield 14 between the shield 14 and the nipple 12
- the bite block may be an extension of the shield material or a hardened nipple shank 126
- the flexible nipple 2 preferably is attached to the bite block
- the bite block will provide a passageway through which the wiring 24 may pass through
- the shield 14 and nipple 12 preferably would be shaped such that multiple catheters would have space to enter the oral cavity, for example, for suction and supplying oxygen
- This alternative embodiment preferably would be for use during surgery of a variety of subjects other than infants and young children
- the device may be a retrofit of current pacifiers by inserting the pulse oximeter sensor elements from a disposable pulse oximeter like the Nellcor® Oxisensor® II oximeters (Malhnckrodt, Inc , St Louis, Missouri, U S A ) by stripping away the packaging and adhesive strip
- the ring attached to must pacifiers would be removed leaving access to the interior cavity of the nipple into which the pulse oximeter sensor elements would be inserted such that they faced in the same general direction
- the ring attached to must pacifiers would be removed leaving access to the interior cavity of the nipple into which the pulse oximeter sensor elements would be inserted such that they faced in the same general direction
- the ring attached to must pacifiers would be removed leaving access to the interior cavity of the nipple into which the pulse oximeter sensor elements would be inserted such that they faced in the same general direction
- a method to take oximeter readings from different sites within a subject which may be either human or animal, for the purposes of determining the amount of oxygen within the blood of the subject
- the oximeter readings are accomplished using reflectance oximetry from capillary beds that are readily accessible within the subject.
- the capillary beds include, for example, the hard palate, the soft palate, the superior lingual surface, the inferior lingual surface, the gingivae, the mouth floor, the buccal surface, and any other surface within the oral cavity
- Each of these capillary beds is accessible through the oral cavity, which extends from the lips to the oral portion of the pharynx, i e , pars oralis
- FIG 27 illustrates a flowchart showing the steps for taking oximeter readings pursuant to the present invention.
- the pulse oximeter sensor elements are connected to an oximeter device such as a spectrophotometer.
- the pacifier 10 is inserted into the subject through the mouth.
- the placement of the pacifier 10 with a pulse oximeter sensor is illustrated, for example, in Figures 17 and 18.
- reflectance pulse oximeter readings are taken from the relevant capillary bed. While taking the pulse oximeter readings, the pulse oximeter sensor elements preferably remain in contact with the relevant capillary bed to continue the flow of accurate oximeter readings.
- the method according to the invention may be used in a variety of surgical, anesthetic, critical care procedures or situations that include patients that are awake, sedated or recovering from general anesthesia.
- a Nellcor® Oxisensor® II D-25 was placed intraoraly between the lower teeth and the left or right buccal surface of the cheek and lip, with the bispectral emitter and detector facing the buccal surface This pulse oximeter sensor orientation was used for the duration of each case
- a similar disposable oximet ⁇ c probe was placed on a peripheral digit in the commonly accepted transillumination configuration At five minute intervals throughout the case, values for both oximet ⁇ c probes were coded on the anesthesia record
- the second protocol involved comparing posterior pharyngeal reflectance pulse oximetry to conventional peripheral transillumination pulse oximetry in difficult to monitor burn patients
- the number of operations per patient ranged from one to
- Nellcor® Oxisensor® II pulse oximeter probe was placed in the distal lumen of an appropriately sized oropharyngeal airway with sensor and emitter facing the posterior pharynx. A similar probe was placed on a peripheral digit as a transilluminating pulse oximeter. SpO 2 values were noted at five-minute intervals. Concordance statistics as well as a .-test for correlated means were calculated between the simultaneously obtained SpO 2 values.
- the third protocol involved taking readings from the lingual surface.
- Nellcor® Oxisensor® II D-25 was centered flat on the superior lingual surface with the detector and the bispectral emitter facing the lingual surface.
- This pulse oximeter configuration was used for the duration of each case.
- an arterial blood gas (ABG) sample was drawn and the SpO 2 noted for clinical monitoring and prior to transfusion in every case All had multiple ABG's drawn and all patients were transfused
- the ABG Sa0 2 oxygen saturation of arterial blood
- the invention is particularly useful for monitoring the blood oxygen content of a subject, more particularity a child or infant
- the invention is also useful when other sites are not available on the patient such as a patient with severe burns covering most of their body or a restless child who is prone to remove attached oximeters to fingers and other body parts
- the invention may be used by hospital personnel, emergency medical crews, in-home medical personnel, laboratory and veterinary personnel and battlefield medical personnel
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002399621A CA2399621A1 (en) | 2000-02-11 | 2001-02-12 | Pacifier pulse oximeter sensor |
AU3687401A AU3687401A (en) | 2000-02-11 | 2001-02-12 | Pacifier pulse oximeter sensor |
EP01909084A EP1257191A1 (en) | 2000-02-11 | 2001-02-12 | Pacifier pulse oximeter sensor |
AU2001236874A AU2001236874B8 (en) | 2000-02-11 | 2001-02-12 | Pacifier pulse oximeter sensor |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18201800P | 2000-02-11 | 2000-02-11 | |
US60/182,018 | 2000-02-11 |
Publications (2)
Publication Number | Publication Date |
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WO2001058349A1 true WO2001058349A1 (en) | 2001-08-16 |
WO2001058349A9 WO2001058349A9 (en) | 2002-11-07 |
Family
ID=22666753
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/004343 WO2001058349A1 (en) | 2000-02-11 | 2001-02-12 | Pacifier pulse oximeter sensor |
Country Status (5)
Country | Link |
---|---|
US (1) | US6470200B2 (en) |
EP (1) | EP1257191A1 (en) |
AU (2) | AU3687401A (en) |
CA (1) | CA2399621A1 (en) |
WO (1) | WO2001058349A1 (en) |
Cited By (10)
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US6533761B2 (en) | 2000-05-31 | 2003-03-18 | The United States Of America As Represented By The Secretary Of The Army | Catheter securing device and bite block |
US6755191B2 (en) | 2000-02-22 | 2004-06-29 | The United States Of America As Represented By The Secretary Of The Army | Securing device for an endotracheal tube |
US6890322B2 (en) | 2000-06-29 | 2005-05-10 | The United States Of America As Represented By The Secretary Of The Army | Catheter securing device |
JP2006340777A (en) * | 2005-06-07 | 2006-12-21 | Takuya Shinkawa | Artificial nipple and nursing observation apparatus for lactation |
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US6890322B2 (en) | 2000-06-29 | 2005-05-10 | The United States Of America As Represented By The Secretary Of The Army | Catheter securing device |
JP2006340777A (en) * | 2005-06-07 | 2006-12-21 | Takuya Shinkawa | Artificial nipple and nursing observation apparatus for lactation |
JP2011520478A (en) * | 2008-04-30 | 2011-07-21 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | Interactive baby bottle |
WO2013061242A1 (en) * | 2011-10-25 | 2013-05-02 | Koninklijke Philips Electronics N.V. | Sleep stage annotation system for infants |
WO2016120875A1 (en) * | 2015-01-28 | 2016-08-04 | Respidx Ltd | Orally inserted probe and method for measuring vital signs |
WO2016148590A1 (en) * | 2015-03-19 | 2016-09-22 | Nicolaus Copernicus University In Torun | System for supporting perceptive and cognitive development of infants and small children |
FR3106750A1 (en) * | 2020-02-03 | 2021-08-06 | Yoomed | CHILD SURVEILLANCE PACIFIER |
Also Published As
Publication number | Publication date |
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AU2001236874B2 (en) | 2004-04-22 |
AU2001236874B8 (en) | 2004-05-27 |
AU3687401A (en) | 2001-08-20 |
CA2399621A1 (en) | 2001-08-16 |
US6470200B2 (en) | 2002-10-22 |
WO2001058349A9 (en) | 2002-11-07 |
US20010029324A1 (en) | 2001-10-11 |
EP1257191A1 (en) | 2002-11-20 |
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