WO2001062377A3 - Microarray fabrication techniques and apparatus - Google Patents

Microarray fabrication techniques and apparatus Download PDF

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Publication number
WO2001062377A3
WO2001062377A3 PCT/US2001/005695 US0105695W WO0162377A3 WO 2001062377 A3 WO2001062377 A3 WO 2001062377A3 US 0105695 W US0105695 W US 0105695W WO 0162377 A3 WO0162377 A3 WO 0162377A3
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WO
WIPO (PCT)
Prior art keywords
capillaries
bundles
microarray
methods
fabrication techniques
Prior art date
Application number
PCT/US2001/005695
Other languages
French (fr)
Other versions
WO2001062377A2 (en
Inventor
Shiping Chen
Yuling Luo
Anthony C Chen
Original Assignee
Genospectra Inc
Shiping Chen
Yuling Luo
Anthony C Chen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genospectra Inc, Shiping Chen, Yuling Luo, Anthony C Chen filed Critical Genospectra Inc
Priority to EP01916171A priority Critical patent/EP1257354A2/en
Priority to AU43228/01A priority patent/AU4322801A/en
Priority to JP2001561433A priority patent/JP2003529056A/en
Priority to CA002400789A priority patent/CA2400789A1/en
Priority to KR1020027010973A priority patent/KR20020097181A/en
Publication of WO2001062377A2 publication Critical patent/WO2001062377A2/en
Publication of WO2001062377A3 publication Critical patent/WO2001062377A3/en

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    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
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    • G01N35/1074—Multiple transfer devices arranged in a two-dimensional array

Abstract

Disclosed is a microarray printing system (100) and methods of printing probe microarrays (1101). The system has a print head (101, 200, 805, 1003, 1700, 1800, 1900) formed of one or more bundles (201-221, 604) of individual capillaries, (102, 301, 402a, 402b, 502a, 502b, 603a, 603b, 802) such as light-guiding capillaries. The bundles may especially be random bundles of capillaries that provide a large number of probes (807, 1006a, 1006b, 1206) on the surface of a substrate. Methods of registering or correlating the distal and proximal ends of the capillaries are also provided. Further, the invention provides methods and equipment for identifying defective microarrays that are missing one or more probes from the surface of the microarray.
PCT/US2001/005695 2000-02-22 2001-02-22 Microarray fabrication techniques and apparatus WO2001062377A2 (en)

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EP01916171A EP1257354A2 (en) 2000-02-22 2001-02-22 Microarray fabrication techniques and apparatus
AU43228/01A AU4322801A (en) 2000-02-22 2001-02-22 Microarray fabrication techniques and apparatus
JP2001561433A JP2003529056A (en) 2000-02-22 2001-02-22 Microarray fabrication technology and equipment
CA002400789A CA2400789A1 (en) 2000-02-22 2001-02-22 Microarray fabrication techniques and apparatus
KR1020027010973A KR20020097181A (en) 2000-02-22 2001-02-22 Microarray fabrication techniques and apparatus

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US18373700P 2000-02-22 2000-02-22
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US21626500P 2000-07-06 2000-07-06
US60/216,265 2000-07-06
US22008500P 2000-07-21 2000-07-21
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CA2400789A1 (en) 2001-08-30
WO2001062377A2 (en) 2001-08-30
JP2003529056A (en) 2003-09-30
CN1404415A (en) 2003-03-19
EP1257354A2 (en) 2002-11-20
AU4322801A (en) 2001-09-03

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